"Proteins Unique Sequence ID" "Checked" "Protein FDR Confidence: Combined" "Master" "Accession" "Description" "Exp. q-value: Combined" "Contaminant" "Sum PEP Score" "Coverage [%]" "# Peptides" "# PSMs" "# Unique Peptides" "# AAs" "MW [kDa]" "calc. pI" "Score Sequest HT: Sequest HT" "# Peptides (by Search Engine): Sequest HT" "Biological Process" "Cellular Component" "Molecular Function" "Pfam IDs" "Entrez Gene ID" "Ensembl Gene ID" "Gene Symbol" "Gene ID" "WikiPathways" "Reactome Pathways" "# Protein Pathway Groups" "# Razor Peptides" "Abundance Ratio: (127N, 47C) / (126, 47C)" "Abundance Ratio: (127C, 47C) / (126, 47C)" "Abundance Ratio: (128N, 47C) / (126, 47C)" "Abundance Ratio: (128C, 47C) / (126, 47C)" "Abundance Ratio: (129N, 47C) / (126, 47C)" "Abundance Ratio: (129C, 47C) / (126, 47C)" "Abundance Ratio: (130N, 47C) / (126, 47C)" "Abundance Ratio: (130C, 47C) / (126, 47C)" "Abundance Ratio: (131, 47C) / (126, 47C)" "Abundances (Grouped): 126, 47C" "Abundances (Grouped): 127N, 47C" "Abundances (Grouped): 127C, 47C" "Abundances (Grouped): 128N, 47C" "Abundances (Grouped): 128C, 47C" "Abundances (Grouped): 129N, 47C" "Abundances (Grouped): 129C, 47C" "Abundances (Grouped): 130N, 47C" "Abundances (Grouped): 130C, 47C" "Abundances (Grouped): 131, 47C" "Abundances (Grouped) CV [%]: 126, 47C" "Abundances (Grouped) CV [%]: 127N, 47C" "Abundances (Grouped) CV [%]: 127C, 47C" "Abundances (Grouped) CV [%]: 128N, 47C" "Abundances (Grouped) CV [%]: 128C, 47C" "Abundances (Grouped) CV [%]: 129N, 47C" "Abundances (Grouped) CV [%]: 129C, 47C" "Abundances (Grouped) CV [%]: 130N, 47C" "Abundances (Grouped) CV [%]: 130C, 47C" "Abundances (Grouped) CV [%]: 131, 47C" "Abundance: F14: 126, Sample, 47C" "Abundance: F14: 127N, Sample, 47C" "Abundance: F14: 127C, Sample, 47C" "Abundance: F14: 128N, Sample, 47C" "Abundance: F14: 128C, Sample, 47C" "Abundance: F14: 129N, Sample, 47C" "Abundance: F14: 129C, Sample, 47C" "Abundance: F14: 130N, Sample, 47C" "Abundance: F14: 130C, Sample, 47C" "Abundance: F14: 131, Sample, 47C" "Abundances Count: F14: 126, Sample, 47C" "Abundances Count: F14: 127N, Sample, 47C" "Abundances Count: F14: 127C, Sample, 47C" "Abundances Count: F14: 128N, Sample, 47C" "Abundances Count: F14: 128C, Sample, 47C" "Abundances Count: F14: 129N, Sample, 47C" "Abundances Count: F14: 129C, Sample, 47C" "Abundances Count: F14: 130N, Sample, 47C" "Abundances Count: F14: 130C, Sample, 47C" "Abundances Count: F14: 131, Sample, 47C" "Found in Sample: [S131] F14: 126, Sample, 47C" "Found in Sample: [S132] F14: 127N, Sample, 47C" "Found in Sample: [S133] F14: 127C, Sample, 47C" "Found in Sample: [S134] F14: 128N, Sample, 47C" "Found in Sample: [S135] F14: 128C, Sample, 47C" "Found in Sample: [S136] F14: 129N, Sample, 47C" "Found in Sample: [S137] F14: 129C, Sample, 47C" "Found in Sample: [S138] F14: 130N, Sample, 47C" "Found in Sample: [S139] F14: 130C, Sample, 47C" "Found in Sample: [S140] F14: 131, Sample, 47C" "# Protein Groups" "Modifications" "5927523368410573672" "False" "High" "IsMasterProtein" "P78527" "DNA-dependent protein kinase catalytic subunit OS=Homo sapiens OX=9606 GN=PRKDC PE=1 SV=3" "0.000" "False" "1125.676" "47" "185" "533" "185" "4128" "468.8" "7.12" "1947.93" "185" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08163, Pf19704, Pf20502" "5591" "ENSG00000253729" "PRKDC" "hsa:5591; P78527; P78528; Q13327; Q13337; Q14175; Q59H99; Q7Z611; Q96SE6; Q9UME3" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; Pathways affected in adenoid cystic carcinoma; Non-homologous end joining; Osteoblast differentiation and related diseases; DNA repair pathways, full network; DNA damage response" "E3 ubiquitin ligases ubiquitinate target proteins; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); IRF3-mediated induction of type I IFN" "13" "0" "1.020" "0.983" "0.941" "0.976" "0.947" "0.946" "0.975" "0.996" "0.744" "50724.9" "51718.2" "49844.5" "47708.2" "49493.3" "48021.8" "48002.4" "49473.2" "50533.8" "37745.6" "" "" "" "" "" "" "" "" "" "" "45606.7" "41848.6" "45086.0" "46569.9" "40842.8" "48021.8" "35943.0" "43698.0" "45217.2" "13474.1" "190" "190" "190" "190" "190" "190" "190" "190" "190" "190" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305783293341844831" "False" "High" "IsMasterProtein" "Q14204" "Cytoplasmic dynein 1 heavy chain 1 OS=Homo sapiens OX=9606 GN=DYNC1H1 PE=1 SV=5" "0.000" "False" "925.142" "44" "184" "357" "184" "4646" "532.1" "6.40" "1321.15" "184" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf18198, Pf18199" "1778" "ENSG00000197102" "DYNC1H1" "B0I1R0; hsa:1778; Q14204; Q6DKQ7; Q8WU28; Q92814; Q9Y4G5" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; PAFAH1B1 copy number variation" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Neutrophil degranulation; COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "24" "0" "0.990" "0.982" "0.963" "0.963" "0.953" "0.987" "0.964" "0.989" "1.080" "28954.5" "28669.6" "28434.3" "27879.2" "27884.1" "27592.0" "28567.5" "27924.7" "28624.3" "31276.6" "" "" "" "" "" "" "" "" "" "" "26033.0" "23198.4" "25719.8" "27214.0" "23010.5" "27592.0" "21390.6" "24664.9" "25612.8" "11164.8" "168" "168" "168" "168" "168" "168" "168" "168" "168" "168" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2962281166201317424" "False" "High" "IsMasterProtein" "P35579" "Myosin-9 OS=Homo sapiens OX=9606 GN=MYH9 PE=1 SV=4" "0.000" "False" "924.372" "59" "120" "529" "95" "1960" "226.4" "5.60" "2057.35" "120" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4627" "ENSG00000100345" "MYH9" "A8K6E4; hsa:4627; O60805; P35579; Q60FE2; Q86T83" "Primary focal segmental glomerulosclerosis (FSGS); VEGFA-VEGFR2 signaling; Nephrotic syndrome; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Signaling by ALK fusions and activated point mutants; RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; CD163 mediating an anti-inflammatory response" "17" "26" "1.051" "1.440" "1.052" "1.096" "1.446" "1.055" "1.110" "1.421" "1.280" "37854.5" "39794.9" "54502.0" "39833.7" "41502.9" "54744.6" "39921.5" "42030.0" "53793.3" "48450.0" "" "" "" "" "" "" "" "" "" "" "34034.9" "32200.6" "49298.8" "38883.2" "34248.9" "54744.6" "29892.2" "37123.6" "48133.9" "17295.3" "138" "138" "138" "138" "138" "138" "138" "138" "138" "138" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4615289327887409645" "False" "High" "IsMasterProtein" "Q9Y490" "Talin-1 OS=Homo sapiens OX=9606 GN=TLN1 PE=1 SV=3" "0.000" "False" "849.916" "59" "125" "352" "111" "2541" "269.6" "6.07" "1447.03" "125" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf16511, Pf21692" "7094" "ENSG00000137076" "TLN1" "A0A1S5UZ07; A6NMY0; hsa:7094; Q86YD0; Q9NZQ2; Q9UHH8; Q9UPX3; Q9Y490" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; TROP2 regulatory signaling" "Platelet degranulation ; p130Cas linkage to MAPK signaling for integrins; Signaling by BRAF and RAF1 fusions; XBP1(S) activates chaperone genes; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins" "18" "12" "1.011" "1.011" "1.022" "1.008" "1.035" "1.032" "1.022" "1.015" "0.899" "29537.4" "29873.1" "29868.5" "30198.4" "29776.1" "30583.4" "30479.6" "30192.2" "29993.0" "26566.1" "" "" "" "" "" "" "" "" "" "" "26557.0" "24172.3" "27017.1" "29477.9" "24571.8" "30583.4" "22822.3" "26667.7" "26837.5" "9483.4" "125" "125" "125" "125" "125" "125" "125" "125" "125" "125" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6252367434931231115" "False" "High" "IsMasterProtein" "P49327" "Fatty acid synthase OS=Homo sapiens OX=9606 GN=FASN PE=1 SV=3" "0.000" "False" "725.483" "54" "104" "342" "103" "2511" "273.3" "6.44" "1314.41" "104" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00107, Pf00109, Pf00550, Pf00698, Pf00975, Pf02801, Pf08242, Pf08659, Pf16197, Pf21089, Pf21149" "2194" "ENSG00000169710" "FASN" "hsa:2194; P49327; Q13479; Q16702; Q4LE83; Q6P4U5; Q6SS02; Q969R1; Q96C68; Q96IT0" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Liver X receptor pathway; Nuclear receptors meta-pathway; Fatty acid biosynthesis; Angiopoietin-like protein 8 regulatory pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-9 fatty acid synthesis; FOXA2 pathway" "ChREBP activates metabolic gene expression; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Vitamin B5 (pantothenate) metabolism" "18" "1" "1.023" "1.043" "0.956" "0.999" "0.998" "1.008" "0.972" "1.046" "0.864" "26695.5" "27305.3" "27839.7" "25520.3" "26673.2" "26651.6" "26896.4" "25946.5" "27917.2" "23053.3" "" "" "" "" "" "" "" "" "" "" "24001.9" "22094.5" "25181.9" "24911.4" "22011.2" "26651.6" "20139.4" "22917.6" "24980.1" "8229.4" "108" "108" "108" "108" "108" "108" "108" "108" "108" "108" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4769002131436570839" "False" "High" "IsMasterProtein" "Q00610" "Clathrin heavy chain 1 OS=Homo sapiens OX=9606 GN=CLTC PE=1 SV=5" "0.000" "False" "604.470" "61" "87" "301" "87" "1675" "191.5" "5.69" "1305.47" "87" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00637, Pf01394, Pf09268, Pf13838" "1213" "ENSG00000141367" "CLTC" "D3DU00; hsa:1213; Q00610; Q6N0A0; Q86TF2" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; Dengue-2 interactions with complement and coagulation cascades; Ebola virus infection in host; Fragile X syndrome; 7q11.23 copy number variation syndrome; Complement and coagulation cascades" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Recycling pathway of L1; MHC class II antigen presentation; RHOV GTPase cycle; Lysosome Vesicle Biogenesis; RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "25" "0" "1.047" "1.050" "1.021" "1.036" "1.063" "1.025" "1.026" "1.095" "0.740" "24484.1" "25622.8" "25714.7" "25006.6" "25359.4" "26016.7" "25105.6" "25123.8" "26817.7" "18122.1" "" "" "" "" "" "" "" "" "" "" "22013.6" "20733.1" "23259.8" "24409.9" "20927.0" "26016.7" "18798.5" "22191.0" "23996.2" "6469.1" "94" "94" "94" "94" "94" "94" "94" "94" "94" "94" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241887692250600056" "False" "High" "IsMasterProtein" "Q15149" "Plectin OS=Homo sapiens OX=9606 GN=PLEC PE=1 SV=3" "0.000" "False" "594.339" "37" "152" "197" "150" "4684" "531.5" "5.96" "738.33" "152" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00681, Pf03501, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "5339" "ENSG00000178209" "PLEC" "hsa:5339; Q15148; Q15149; Q16640; Q6S376; Q6S377; Q6S378; Q6S379; Q6S380; Q6S381; Q6S382; Q6S383" "Envelope proteins and their potential roles in EDMD physiopathology" "Assembly of collagen fibrils and other multimeric structures; Caspase-mediated cleavage of cytoskeletal proteins; Type I hemidesmosome assembly" "4" "0" "1.016" "1.049" "0.998" "1.003" "1.043" "1.066" "0.948" "0.995" "1.648" "12818.2" "13027.6" "13449.3" "12795.5" "12851.5" "13369.9" "13670.4" "12154.7" "12749.2" "21129.5" "" "" "" "" "" "" "" "" "" "" "11524.8" "10541.5" "12165.3" "12490.2" "10605.3" "13369.9" "10236.1" "10735.8" "11407.9" "7542.6" "107" "107" "107" "107" "107" "107" "107" "107" "107" "107" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3910954529377130988" "False" "High" "IsMasterProtein" "Q9UPN3" "Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 OS=Homo sapiens OX=9606 GN=MACF1 PE=1 SV=4" "0.000" "False" "592.296" "22" "144" "182" "139" "7388" "837.8" "5.39" "706.01" "144" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "23499" "ENSG00000127603" "MACF1" "B1ALC5; E9PJT0; hsa:23499; O75053; Q5VW20; Q8WXY1; Q8WXY2; Q96PK2; Q9H540; Q9UKP0; Q9ULG9; Q9UPN3" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "2" "1.038" "0.984" "0.981" "1.026" "0.959" "1.015" "1.004" "0.971" "0.947" "15707.1" "16303.8" "15451.1" "15413.7" "16115.6" "15061.8" "15949.3" "15774.2" "15255.3" "14880.7" "" "" "" "" "" "" "" "" "" "" "14122.2" "13192.5" "13976.0" "15045.9" "13298.9" "15061.8" "11942.4" "13932.8" "13650.4" "5312.0" "106" "106" "106" "106" "106" "106" "106" "106" "106" "106" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705476780399299386" "False" "High" "IsMasterProtein" "P46940" "Ras GTPase-activating-like protein IQGAP1 OS=Homo sapiens OX=9606 GN=IQGAP1 PE=1 SV=1" "0.000" "False" "508.187" "47" "68" "220" "66" "1657" "189.1" "6.48" "906.73" "68" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "8826" "ENSG00000140575" "IQGAP1" "A7MBM3; hsa:8826; P46940" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ciliary landscape; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RHOV GTPase cycle; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; RHOU GTPase cycle; Nephrin family interactions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "25" "3" "0.973" "0.996" "0.981" "0.966" "0.949" "0.956" "0.953" "1.014" "0.872" "18560.9" "18057.3" "18478.9" "18216.9" "17928.5" "17611.4" "17744.3" "17681.5" "18816.2" "16189.4" "" "" "" "" "" "" "" "" "" "" "16688.1" "14611.3" "16714.8" "17782.2" "14794.9" "17611.4" "13286.5" "15617.5" "16836.6" "5779.1" "71" "71" "71" "71" "71" "71" "71" "71" "71" "71" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7065009906831580898" "False" "High" "IsMasterProtein" "P07900" "Heat shock protein HSP 90-alpha OS=Homo sapiens OX=9606 GN=HSP90AA1 PE=1 SV=5" "0.000" "False" "467.758" "65" "59" "576" "39" "732" "84.6" "5.02" "2046.20" "59" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3320" "ENSG00000080824" "HSP90AA1" "A8K500; B3KPJ9; hsa:3320; P07900; Q2PP14; Q5CAQ6; Q5CAQ7; Q9BVQ5" "Nucleotide-binding oligomerization domain (NOD) pathway; TNF-alpha signaling pathway; Corticotropin-releasing hormone signaling pathway; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Aryl hydrocarbon receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced AP-1 survival signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Th17 cell differentiation pathway; HDAC6 interactions in the central nervous system" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Extra-nuclear estrogen signaling; Neutrophil degranulation; vRNP Assembly; Estrogen-dependent gene expression; Regulation of necroptotic cell death; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; PIWI-interacting RNA (piRNA) biogenesis; VEGFR2 mediated vascular permeability; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Uptake and function of diphtheria toxin; Constitutive Signaling by Overexpressed ERBB2; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication; Scavenging by Class F Receptors; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "71" "3" "0.978" "1.001" "1.109" "0.948" "1.005" "0.945" "1.006" "1.017" "0.818" "24326.0" "23779.9" "24356.2" "26982.4" "23053.6" "24446.1" "22995.1" "24464.9" "24731.4" "19905.7" "" "" "" "" "" "" "" "" "" "" "21871.4" "19241.8" "22031.0" "26338.6" "19024.3" "24446.1" "17218.2" "21609.0" "22129.5" "7105.8" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2220837361715177214" "False" "High" "IsMasterProtein" "P08238" "Heat shock protein HSP 90-beta OS=Homo sapiens OX=9606 GN=HSP90AB1 PE=1 SV=4" "0.000" "False" "462.865" "66" "60" "598" "25" "724" "83.2" "5.03" "2187.48" "60" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "3326" "ENSG00000096384" "HSP90AB1" "B2R5P0; hsa:3326; P08238; Q5T9W7; Q9NQW0; Q9NTK6" "Nuclear receptors meta-pathway; NRF2 pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; Potential therapeutics for SARS; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aryl hydrocarbon receptor signalling; Neutrophil degranulation; Estrogen-dependent gene expression; Sema3A PAK dependent Axon repulsion; DDX58/IFIH1-mediated induction of interferon-alpha/beta; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; RHOBTB2 GTPase cycle; Chaperone Mediated Autophagy; HSF1 activation; Attenuation phase; Uptake and function of diphtheria toxin; Assembly and release of respiratory syncytial virus (RSV) virions; Respiratory syncytial virus genome replication" "25" "38" "0.996" "0.998" "1.120" "0.956" "1.033" "0.968" "1.010" "0.994" "0.848" "56587.1" "56387.4" "56492.9" "63374.6" "54112.1" "58432.2" "54782.3" "57129.4" "56220.0" "48010.9" "" "" "" "" "" "" "" "" "" "" "50877.3" "45626.7" "51099.7" "61862.4" "44654.3" "58432.2" "41019.6" "50460.4" "50305.2" "17138.5" "64" "64" "64" "64" "64" "64" "64" "64" "64" "64" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7834140751544997544" "False" "High" "IsMasterProtein" "Q7Z6Z7" "E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens OX=9606 GN=HUWE1 PE=1 SV=3" "0.000" "False" "459.237" "25" "96" "180" "96" "4374" "481.6" "5.22" "640.90" "96" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00627, Pf00632, Pf02825, Pf06012, Pf06025, Pf14377" "10075" "ENSG00000086758" "HUWE1" "hsa:10075; O15029; Q4G2Z2; Q5H961; Q6P4D0; Q7Z6Z7; Q8NG67; Q9BUI0; Q9HCJ4; Q9NSL6; Q9P0A9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.043" "0.983" "0.970" "1.017" "0.970" "1.027" "1.002" "0.986" "0.976" "11443.6" "11931.1" "11247.1" "11101.5" "11640.2" "11101.7" "11753.5" "11471.2" "11278.0" "11165.4" "" "" "" "" "" "" "" "" "" "" "10288.9" "9654.2" "10173.4" "10836.6" "9605.7" "11101.7" "8800.7" "10132.1" "10091.5" "3985.7" "79" "79" "79" "79" "79" "79" "79" "79" "79" "79" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7017874985935534894" "False" "High" "IsMasterProtein" "P18206" "Vinculin OS=Homo sapiens OX=9606 GN=VCL PE=1 SV=4" "0.000" "False" "445.971" "60" "65" "232" "65" "1134" "123.7" "5.66" "859.66" "65" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "7414" "ENSG00000035403" "VCL" "hsa:7414; P18206; Q16450; Q5SWX2; Q7Z3B8; Q8IXU7" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; VEGFA-VEGFR2 signaling; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Melanoma; Regulation of actin cytoskeleton" "Platelet degranulation ; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "18" "0" "1.003" "0.985" "1.002" "0.993" "0.970" "1.000" "1.023" "0.970" "0.807" "22766.9" "22829.6" "22427.8" "22809.2" "22615.7" "22093.4" "22769.6" "23293.5" "22086.5" "18373.2" "" "" "" "" "" "" "" "" "" "" "20469.7" "18472.9" "20286.7" "22264.9" "18662.9" "22093.4" "17049.3" "20574.3" "19762.9" "6558.7" "73" "73" "73" "73" "73" "73" "73" "73" "73" "73" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5619484675981056092" "False" "High" "IsMasterProtein" "P10809" "60 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPD1 PE=1 SV=2" "0.000" "False" "444.192" "80" "47" "503" "47" "573" "61.0" "5.87" "2029.74" "47" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00118" "3329" "ENSG00000144381" "HSPD1" "B2R5M6; B7Z712; hsa:3329; P10809; Q38L19; Q9UCR6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; 8p23.1 copy number variation syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "Mitochondrial protein degradation; Mitochondrial protein import; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "6" "0" "1.030" "1.007" "1.053" "1.004" "1.041" "0.989" "1.059" "1.033" "0.818" "34407.8" "35433.6" "34660.5" "36241.1" "34535.7" "35804.6" "34034.7" "36425.6" "35540.0" "28156.2" "" "" "" "" "" "" "" "" "" "" "30936.0" "28671.6" "31351.6" "35376.4" "28499.5" "35804.6" "25484.3" "32173.5" "31801.0" "10051.0" "59" "59" "59" "59" "59" "59" "59" "59" "59" "59" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-613397371873318473" "False" "High" "IsMasterProtein" "P34932" "Heat shock 70 kDa protein 4 OS=Homo sapiens OX=9606 GN=HSPA4 PE=1 SV=4" "0.000" "False" "441.616" "66" "54" "246" "51" "840" "94.3" "5.19" "893.31" "54" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00012" "3308" "ENSG00000170606" "HSPA4" "hsa:3308; O95756; P34932; Q2TAL4; Q9BUK9" "Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response" "3" "4" "1.000" "0.973" "0.992" "0.976" "0.948" "0.979" "0.975" "0.965" "0.778" "22981.5" "22990.5" "22367.6" "22802.5" "22420.0" "21779.0" "22487.9" "22400.5" "22177.5" "17878.8" "" "" "" "" "" "" "" "" "" "" "20662.6" "18603.1" "20232.2" "22258.4" "18501.4" "21779.0" "16838.4" "19785.6" "19844.3" "6382.2" "68" "68" "68" "68" "68" "68" "68" "68" "68" "68" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-66753491464337277" "False" "High" "IsMasterProtein" "Q13813" "Spectrin alpha chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTAN1 PE=1 SV=3" "0.000" "False" "435.736" "45" "100" "138" "100" "2472" "284.4" "5.35" "536.49" "100" "cell organization and biogenesis" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00435, Pf08726, Pf13499" "6709" "ENSG00000197694" "SPTAN1" "hsa:6709; Q13186; Q13813; Q15324; Q16606; Q59EF1; Q5VXV5; Q5VXV6; Q7Z6M5; Q9P0V0" "Fas ligand pathway and stress induction of heat shock proteins" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Interaction between L1 and Ankyrins; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Caspase-mediated cleavage of cytoskeletal proteins" "12" "0" "1.005" "1.109" "1.016" "1.028" "1.081" "1.031" "1.023" "1.098" "0.919" "10168.7" "10215.6" "11277.5" "10333.1" "10451.0" "10992.6" "10480.3" "10401.6" "11168.7" "9340.5" "" "" "" "" "" "" "" "" "" "" "9142.6" "8266.1" "10200.8" "10086.6" "8624.4" "10992.6" "7847.4" "9187.3" "9993.7" "3334.3" "71" "71" "71" "71" "71" "71" "71" "71" "71" "71" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015185769260426388" "False" "High" "IsMasterProtein" "P53396" "ATP-citrate synthase OS=Homo sapiens OX=9606 GN=ACLY PE=1 SV=3" "0.000" "False" "432.593" "56" "56" "274" "56" "1101" "120.8" "7.33" "998.31" "56" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00285, Pf00549, Pf02629, Pf16114" "47" "ENSG00000131473" "ACLY" "B4DIM0; B4E3P0; hsa:47; P53396; Q13037; Q9BRL0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Fatty acid biosynthesis; Amino acid metabolism; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer" "Neutrophil degranulation; ChREBP activates metabolic gene expression; Fatty acyl-CoA biosynthesis" "10" "0" "1.007" "1.024" "0.996" "0.971" "1.010" "0.968" "0.959" "1.019" "0.778" "24223.6" "24393.0" "24798.9" "24130.5" "23518.5" "24473.3" "23460.5" "23225.8" "24690.7" "18846.8" "" "" "" "" "" "" "" "" "" "" "21779.4" "19738.0" "22431.4" "23554.7" "19407.9" "24473.3" "17566.7" "20514.5" "22093.1" "6727.8" "72" "72" "72" "72" "72" "72" "72" "72" "72" "72" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6488855965708197639" "False" "High" "IsMasterProtein" "P14618" "Pyruvate kinase PKM OS=Homo sapiens OX=9606 GN=PKM PE=1 SV=4" "0.000" "False" "429.175" "79" "49" "496" "46" "531" "57.9" "7.84" "1981.75" "49" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00224, Pf02887" "5315" "ENSG00000067225" "PKM" "A6NFK3; B2R5N8; B3KRY0; B4DFX8; B4DUU6; hsa:5315; P14618; P14786; Q53GK4; Q96E76; Q9BWB5; Q9UCV6; Q9UPF2" "Photodynamic therapy-induced HIF-1 survival signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation" "10" "2" "1.024" "1.025" "1.137" "0.964" "1.025" "0.980" "0.974" "1.049" "0.777" "41318.6" "42294.5" "42341.9" "46991.5" "39838.8" "42332.8" "40474.0" "40225.8" "43358.9" "32098.2" "" "" "" "" "" "" "" "" "" "" "37149.5" "34223.2" "38299.7" "45870.3" "32875.7" "42332.8" "30305.9" "35530.0" "38797.2" "11458.2" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5005343800474254733" "False" "High" "IsMasterProtein" "P13796" "Plastin-2 OS=Homo sapiens OX=9606 GN=LCP1 PE=1 SV=6" "0.000" "False" "427.628" "77" "45" "635" "36" "627" "70.2" "5.43" "2152.15" "45" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00036, Pf00307" "3936" "ENSG00000136167" "LCP1" "B2R613; B4DUA0; hsa:3936; P13796; Q5TBN4" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "12" "1.013" "1.016" "1.016" "1.005" "0.996" "0.996" "1.001" "0.999" "0.810" "45414.5" "46026.9" "46124.4" "46154.9" "45627.5" "45234.6" "45241.6" "45447.0" "45383.0" "36806.2" "" "" "" "" "" "" "" "" "" "" "40832.1" "37243.3" "41721.0" "45053.6" "37652.6" "45234.6" "33875.8" "40141.8" "40608.3" "13138.8" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819136565778515185" "False" "High" "IsMasterProtein" "P13639" "Elongation factor 2 OS=Homo sapiens OX=9606 GN=EEF2 PE=1 SV=4" "0.000" "False" "421.390" "67" "54" "445" "53" "858" "95.3" "6.83" "1538.78" "54" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "1938" "ENSG00000167658" "EEF2" "A0A384N6H1; B2RMP5; D6W618; hsa:1938; P13639; Q58J86" "Translation factors; AMP-activated protein kinase signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-18 signaling pathway" "Neutrophil degranulation; Protein methylation; Uptake and function of diphtheria toxin; Peptide chain elongation; Synthesis of diphthamide-EEF2" "9" "1" "1.014" "0.995" "1.047" "1.003" "1.003" "0.992" "1.023" "1.009" "0.807" "42049.5" "42653.4" "41846.7" "44046.2" "42185.8" "42181.9" "41704.5" "43019.8" "42409.5" "33938.5" "" "" "" "" "" "" "" "" "" "" "37806.6" "34513.6" "37851.7" "42995.2" "34812.5" "42181.9" "31227.3" "37997.9" "37947.7" "12115.1" "66" "66" "66" "66" "66" "66" "66" "66" "66" "66" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6896953880380314494" "False" "High" "IsMasterProtein" "P55072" "Transitional endoplasmic reticulum ATPase OS=Homo sapiens OX=9606 GN=VCP PE=1 SV=4" "0.000" "False" "408.482" "65" "54" "217" "54" "806" "89.3" "5.26" "808.98" "54" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "7415" "ENSG00000165280" "VCP" "B2R5T8; P55072; Q0V924; Q2TAI5; Q969G7; Q9UCD5; V9HW80" "Alstrom syndrome; Clock-controlled autophagy in bone metabolism; HDAC6 interactions in the central nervous system" "Aggrephagy; Neutrophil degranulation; HSF1 activation; RHOH GTPase cycle; E3 ubiquitin ligases ubiquitinate target proteins; ABC-family proteins mediated transport; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Defective CFTR causes cystic fibrosis; Neddylation; KEAP1-NFE2L2 pathway; Attachment and Entry; Attachment and Entry; Ovarian tumor domain proteases; Josephin domain DUBs; Protein methylation; Translesion Synthesis by POLH; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "21" "0" "1.009" "0.990" "1.007" "0.992" "0.978" "0.988" "0.998" "0.996" "0.784" "18849.1" "19025.7" "18661.3" "18980.8" "18689.0" "18442.6" "18625.8" "18819.6" "18776.7" "14785.6" "" "" "" "" "" "" "" "" "" "" "16947.2" "15394.9" "16879.8" "18527.9" "15422.5" "18442.6" "13946.5" "16622.7" "16801.2" "5278.0" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823981804521467878" "False" "High" "IsMasterProtein" "P46013" "Proliferation marker protein Ki-67 OS=Homo sapiens OX=9606 GN=MKI67 PE=1 SV=2" "0.000" "False" "403.338" "33" "83" "134" "83" "3256" "358.5" "9.45" "489.52" "83" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf08065, Pf15276" "4288" "ENSG00000148773" "MKI67" "hsa:4288; P46013; Q5VWH2" "Primary focal segmental glomerulosclerosis (FSGS)" "" "1" "0" "0.972" "0.999" "0.950" "0.983" "1.207" "1.047" "0.893" "0.872" "0.966" "11754.2" "11426.5" "11748.2" "11166.7" "11555.4" "14184.0" "12310.1" "10501.3" "10253.7" "11355.5" "" "" "" "" "" "" "" "" "" "" "10568.2" "9245.9" "10626.6" "10900.3" "9535.7" "14184.0" "9217.5" "9275.4" "9175.0" "4053.6" "68" "68" "68" "68" "68" "68" "68" "68" "68" "68" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7449371538365957033" "False" "High" "IsMasterProtein" "P12270" "Nucleoprotein TPR OS=Homo sapiens OX=9606 GN=TPR PE=1 SV=3" "0.000" "False" "401.266" "38" "81" "157" "80" "2363" "267.1" "5.02" "607.63" "81" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf07926" "7175" "ENSG00000047410" "TPR" "hsa:7175; P12270; Q15624; Q15655; Q5SWY0; Q99968" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signaling by ALK fusions and activated point mutants" "29" "1" "1.047" "1.074" "1.012" "1.094" "1.091" "1.071" "1.073" "1.054" "1.416" "13196.0" "13809.7" "14171.8" "13352.1" "14432.2" "14401.8" "14126.7" "14165.8" "13911.8" "18691.4" "" "" "" "" "" "" "" "" "" "" "11864.5" "11174.3" "12818.8" "13033.5" "11909.7" "14401.8" "10577.7" "12512.1" "12448.2" "6672.3" "73" "73" "73" "73" "73" "73" "73" "73" "73" "73" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5864065326781896084" "False" "High" "IsMasterProtein" "P27708" "Multifunctional protein CAD OS=Homo sapiens OX=9606 GN=CAD PE=1 SV=3" "0.000" "False" "394.983" "41" "68" "145" "68" "2225" "242.8" "6.46" "570.88" "68" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00117, Pf00185, Pf00988, Pf01979, Pf02142, Pf02729, Pf02786, Pf02787" "790" "ENSG00000084774" "CAD" "D6W552; hsa:790; P27708; Q6P0Q0; Q96CK3" "Endothelin pathways; Amino acid metabolism; Pyrimidine metabolism" "Pyrimidine biosynthesis" "4" "0" "1.068" "1.096" "0.974" "1.045" "1.046" "1.026" "1.052" "1.112" "1.138" "9627.1" "10281.6" "10546.6" "9374.0" "10061.2" "10070.9" "9875.5" "10127.1" "10706.0" "10953.6" "" "" "" "" "" "" "" "" "" "" "8655.7" "8319.5" "9539.7" "9150.3" "8302.7" "10070.9" "7394.5" "8944.9" "9579.7" "3910.1" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752798674986433827" "False" "High" "IsMasterProtein" "Q5T4S7" "E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens OX=9606 GN=UBR4 PE=1 SV=1" "0.000" "False" "394.396" "21" "97" "138" "97" "5183" "573.5" "6.04" "499.83" "97" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02207, Pf13764, Pf19423" "23352" "ENSG00000127481" "UBR4" "A8MPT2; A8MQ33; A8MQB1; O60646; O75050; Q4QRK5; Q5T4S7; Q5T4S8; Q5T4S9; Q5TBN8; Q5TBP2; Q6DKH8; Q6P4A4; Q7L8P7; Q8IXJ4; Q8TDN5; Q8WV67; Q9HA46; Q9P2N9; Q9UG82" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neutrophil degranulation" "2" "0" "1.007" "1.003" "0.955" "0.997" "0.971" "0.987" "0.952" "1.025" "0.982" "10119.5" "10189.0" "10148.8" "9664.3" "10091.4" "9829.7" "9991.9" "9636.5" "10375.4" "9938.1" "" "" "" "" "" "" "" "" "" "" "9098.4" "8244.6" "9179.9" "9433.7" "8327.6" "9829.7" "7481.7" "8511.6" "9283.9" "3547.6" "76" "76" "76" "76" "76" "76" "76" "76" "76" "76" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453697574232543386" "False" "High" "IsMasterProtein" "O43707" "Alpha-actinin-4 OS=Homo sapiens OX=9606 GN=ACTN4 PE=1 SV=2" "0.000" "False" "389.480" "68" "56" "206" "56" "911" "104.8" "5.44" "792.86" "56" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00307, Pf00435, Pf08726" "81" "ENSG00000130402; ENSG00000282844" "ACTN4" "A4K467; D6PXK4; hsa:81; O43707; O76048" "Arrhythmogenic right ventricular cardiomyopathy; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Striated muscle contraction pathway; Ebola virus infection in host; Nephrotic syndrome; Alstrom syndrome" "Platelet degranulation ; Nephrin family interactions" "9" "0" "1.005" "1.049" "1.026" "0.995" "1.036" "1.004" "1.028" "1.049" "0.756" "17532.3" "17618.4" "18399.9" "17983.9" "17447.9" "18170.2" "17606.0" "18023.9" "18397.3" "13256.9" "" "" "" "" "" "" "" "" "" "" "15763.2" "14256.2" "16643.3" "17554.8" "14398.3" "18170.2" "13182.9" "15919.9" "16461.8" "4732.3" "57" "57" "57" "57" "57" "57" "57" "57" "57" "57" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8277375164580502172" "False" "High" "IsMasterProtein" "Q14683" "Structural maintenance of chromosomes protein 1A OS=Homo sapiens OX=9606 GN=SMC1A PE=1 SV=2" "0.000" "False" "372.460" "54" "69" "154" "68" "1233" "143.1" "7.64" "542.26" "69" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "8243" "ENSG00000072501" "SMC1A" "hsa:8243; O14995; Q14683; Q16351; Q2M228" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Pathways affected in adenoid cystic carcinoma; ATM signaling in development and disease ; mRNA processing; Regulation of sister chromatid separation at the metaphase-anaphase transition; Rett syndrome; CAMKK2 pathway; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation; DNA damage response" "Estrogen-dependent gene expression; Meiotic synapsis; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "22" "1" "1.001" "1.009" "0.981" "0.987" "0.991" "0.969" "1.022" "1.002" "0.809" "15999.1" "16017.8" "16147.9" "15694.1" "15797.7" "15852.2" "15503.8" "16351.2" "16035.1" "12942.6" "" "" "" "" "" "" "" "" "" "" "14384.7" "12961.0" "14606.3" "15319.6" "13036.6" "15852.2" "11608.9" "14442.4" "14348.1" "4620.1" "70" "70" "70" "70" "70" "70" "70" "70" "70" "70" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6880355764133463335" "False" "High" "IsMasterProtein" "P26358" "DNA (cytosine-5)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=DNMT1 PE=1 SV=2" "0.000" "False" "371.311" "43" "62" "142" "62" "1616" "183.1" "7.75" "556.45" "62" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf01426, Pf02008, Pf06464, Pf12047" "1786" "ENSG00000130816" "DNMT1" "A0AV63; B7ZLW6; hsa:1786; P26358; Q9UHG5; Q9ULA2; Q9UMZ6" "Trans-sulfuration pathway; One-carbon metabolism; Retinoblastoma gene in cancer; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; MTHFR deficiency; Spina bifida" "SUMOylation of DNA methylation proteins; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; Nuclear events stimulated by ALK signaling in cancer" "13" "0" "0.980" "1.018" "0.990" "0.970" "1.014" "0.954" "0.991" "0.985" "0.818" "13682.9" "13408.1" "13922.5" "13539.7" "13267.6" "13877.9" "13049.7" "13560.6" "13482.9" "11199.2" "" "" "" "" "" "" "" "" "" "" "12302.3" "10849.3" "12593.4" "13216.6" "10948.7" "13877.9" "9771.3" "11977.6" "12064.4" "3997.8" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256395688163039861" "False" "High" "IsMasterProtein" "O75643" "U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=2" "0.000" "False" "360.311" "37" "70" "127" "70" "2136" "244.4" "6.06" "474.44" "70" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf02889, Pf18149, Pf21188" "23020" "ENSG00000144028" "SNRNP200" "hsa:23020; O75643; O94884; Q6NZY0; Q6PX59; Q8NBE6; Q96IF2; Q9H7S0" "2q11.2 copy number variation syndrome" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.966" "0.959" "0.898" "0.963" "0.995" "0.949" "0.895" "0.918" "0.887" "10459.2" "10103.3" "10028.1" "9389.6" "10076.8" "10411.0" "9924.5" "9360.9" "9599.7" "9275.9" "" "" "" "" "" "" "" "" "" "" "9403.9" "8175.2" "9070.8" "9165.5" "8315.6" "10411.0" "7431.2" "8268.2" "8589.7" "3311.2" "62" "62" "62" "62" "62" "62" "62" "62" "62" "62" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4567547795878987385" "False" "High" "IsMasterProtein" "P21333" "Filamin-A OS=Homo sapiens OX=9606 GN=FLNA PE=1 SV=4" "0.000" "False" "359.530" "40" "79" "107" "73" "2647" "280.6" "6.06" "467.41" "79" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2316" "ENSG00000196924" "FLNA" "E9KL45; hsa:2316; P21333; Q5HY53; Q5HY55; Q8NF52" "Androgen receptor signaling pathway; Prolactin signaling pathway; Focal adhesion; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; IL-4 signaling pathway; Ebola virus infection in host; Joubert syndrome; NPHP1 deletion syndrome" "OAS antiviral response; Platelet degranulation ; RHO GTPases activate PAKs; GP1b-IX-V activation signalling; Cell-extracellular matrix interactions" "14" "5" "1.020" "1.145" "1.013" "1.010" "1.161" "0.989" "1.001" "1.176" "0.937" "9026.8" "9205.1" "10338.1" "9142.3" "9120.9" "10484.6" "8923.5" "9035.6" "10611.7" "8454.4" "" "" "" "" "" "" "" "" "" "" "8116.0" "7448.4" "9351.2" "8924.2" "7526.7" "10484.6" "6681.7" "7980.8" "9495.3" "3018.0" "60" "60" "60" "60" "60" "60" "60" "60" "60" "60" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5926930809007955556" "False" "High" "IsMasterProtein" "Q92598" "Heat shock protein 105 kDa OS=Homo sapiens OX=9606 GN=HSPH1 PE=1 SV=1" "0.000" "False" "358.208" "66" "50" "191" "45" "858" "96.8" "5.39" "746.78" "50" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "10808" "ENSG00000120694" "HSPH1" "B4DYH1; hsa:10808; O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q92598; Q9UPC4" "" "Regulation of HSF1-mediated heat shock response; Scavenging by Class F Receptors" "2" "2" "1.026" "1.022" "1.005" "1.005" "1.047" "0.982" "1.023" "1.034" "0.917" "15864.7" "16275.8" "16213.2" "15941.9" "15948.7" "16603.1" "15572.8" "16223.9" "16411.6" "14543.0" "" "" "" "" "" "" "" "" "" "" "14263.9" "13169.8" "14665.4" "15561.5" "13161.2" "16603.1" "11660.5" "14330.0" "14685.0" "5191.4" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9133260577685858014" "False" "High" "IsMasterProtein" "O00410" "Importin-5 OS=Homo sapiens OX=9606 GN=IPO5 PE=1 SV=4" "0.000" "False" "350.776" "60" "48" "157" "45" "1097" "123.6" "4.94" "602.58" "48" "transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985, Pf18808, Pf18816, Pf18829" "3843" "ENSG00000065150" "IPO5" "B4DZA0; hsa:3843; O00410; O15257; Q5T578; Q86XC7" "" "vRNP Assembly" "1" "2" "1.020" "0.973" "0.979" "1.003" "0.944" "1.005" "0.986" "0.958" "0.954" "12034.9" "12275.9" "11715.4" "11781.1" "12074.1" "11356.7" "12095.2" "11867.2" "11528.3" "11476.6" "" "" "" "" "" "" "" "" "" "" "10820.5" "9933.3" "10596.9" "11500.0" "9963.8" "11356.7" "9056.6" "10481.9" "10315.5" "4096.8" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642176776796334220" "False" "High" "IsMasterProtein" "P35580" "Myosin-10 OS=Homo sapiens OX=9606 GN=MYH10 PE=1 SV=3" "0.000" "False" "345.376" "40" "66" "119" "47" "1976" "228.9" "5.54" "477.04" "66" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00612, Pf01576, Pf02736" "4628" "ENSG00000133026" "MYH10" "B2RWP9; D3DTS1; F8VTL3; hsa:4628; P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0" "Regulation of actin cytoskeleton" "EPHA-mediated growth cone collapse; RHO GTPases activate PAKs; RHO GTPases activate CIT; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs" "7" "2" "0.971" "1.273" "0.931" "0.999" "1.290" "0.977" "1.031" "1.292" "1.281" "5148.6" "4999.6" "6552.3" "4795.4" "5145.0" "6639.9" "5031.6" "5306.7" "6653.5" "6596.6" "" "" "" "" "" "" "" "" "" "" "4629.1" "4045.5" "5926.8" "4681.0" "4245.8" "6639.9" "3767.6" "4687.2" "5953.5" "2354.8" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-772083225745130744" "False" "High" "IsMasterProtein" "P11142" "Heat shock cognate 71 kDa protein OS=Homo sapiens OX=9606 GN=HSPA8 PE=1 SV=1" "0.000" "False" "343.070" "67" "42" "371" "27" "646" "70.9" "5.52" "1421.19" "42" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3312" "ENSG00000109971" "HSPA8" "hsa:3312; P11142; Q9H3R6" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Exercise-induced circadian regulation; Measles virus infection; Opioid receptor pathways; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Neutrophil degranulation; Late endosomal microautophagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; mRNA Splicing - Major Pathway; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; GABA synthesis, release, reuptake and degradation; Lipophagy; Chaperone Mediated Autophagy; Protein methylation; Attenuation phase; Respiratory syncytial virus genome transcription" "27" "13" "1.022" "1.028" "1.070" "0.976" "1.051" "0.983" "1.041" "1.011" "0.868" "35127.4" "35897.3" "36109.9" "37580.3" "34275.4" "36931.8" "34530.6" "36555.2" "35499.0" "30496.4" "" "" "" "" "" "" "" "" "" "" "31583.0" "29046.8" "32662.5" "36683.5" "28284.6" "36931.8" "25855.7" "32287.9" "31764.3" "10886.4" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-174490317750568225" "False" "High" "IsMasterProtein" "Cont_P60712" "Actin, cytoplasmic 1 OS=Bos taurus OX=9913 GN=ACTB PE=1 SV=1" "0.000" "True" "336.959" "76" "29" "1141" "9" "375" "41.7" "5.48" "4411.21" "29" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "100011313; 100011351; 100033878; 100078865; 100135470; 100173832; 100303677; 100654618; 100689477; 100919051; 101026869; 101098507; 101375328; 101813373; 101844587; 101941176; 101958638; 102030392; 102041442; 102067189; 102179831; 102286048; 102386754; 102744309; 102772396; 102884469; 103050159; 103077223; 103115297; 103197222; 105077471; 105294565; 105497365; 105551087; 105719490; 105868294; 105990935; 106497948; 107155983; 107515934; 108496585; 108538237; 109314696; 109380220; 109700700; 11461; 280979; 396526; 403580; 414396; 443052; 450133; 574285; 60; 81822" "ENSABRG00000002004; ENSACOG00000001373; ENSACUG00000014525; ENSAMEG00000019137; ENSAMEG00000025519; ENSAMEG00000030859; ENSANAG00000024575; ENSAPLG00020013590; ENSBIXG00000014387; ENSBIXG00005017151; ENSBJAG00000012824; ENSBOBG00000008860; ENSBTAG00000026199; ENSCABG00000005869; ENSCAFG00000016020; ENSCAFG00030015381; ENSCAFG00040015695; ENSCAFG00805000771; ENSCCEG00000022540; ENSCCNG00000030119; ENSCGRG00001015781; ENSCHIG00000013316; ENSCJAG00000074750; ENSCJAG00000083114; ENSCLAG00000013196; ENSCMUG00000004054; ENSCPBG00000020809; ENSCPGG00000001752; ENSCPOG00000013467; ENSCPRG00005016203; ENSCPVG00000014059; ENSCSRG00000014125; ENSCUSG00005013766; ENSDLEG00000020930; ENSFALG00000013828; ENSFCAG00000006788; ENSFTIG00000005623; ENSG00000075624; ENSGAGG00000004381; ENSGEVG00005007981; ENSGGOG00000001133; ENSJHYG00000006128; ENSJJAG00000018929; ENSLCNG00005020599; ENSMCSG00000014736; ENSMICG00000002791; ENSMLEG00000038914; ENSMMMG00000007553; ENSMMNG00015004465; ENSMMSG00000018023; ENSMMUG00000011153; ENSMNEG00000033949; ENSMODG00000002647; ENSMPUG00000016612; ENSMUGG00000013478; ENSMUNG00000007311; ENSMUSG00000029580; ENSNVIG00000005620; ENSOANG00000007716; ENSOARG00020008714; ENSOSUG00000006211; ENSPANG00000015700; ENSPCEG00000013440; ENSPCLG00000014414; ENSPCTG00005017252; ENSPEMG00000012952; ENSPLOG00000015512; ENSPPYG00000017336; ENSPSTG00000003558; ENSPTEG00000021167; ENSPTRG00000018890; ENSPTXG00000006649; ENSRBIG00000014104; ENSRFEG00010011816; ENSRNOG00000034254; ENSRNOG00055011660; ENSRNOG00060020294; ENSRNOG00065000139; ENSSBOG00000033859; ENSSHAG00000029431; ENSSHBG00005009495; ENSSOCG00000011957; ENSSSCG00000007585; ENSSSCG00005020690; ENSSSCG00030003451; ENSSSCG00035038792; ENSSSCG00040049462; ENSSSCG00045027458; ENSSSCG00050065025; ENSSSCG00055012597; ENSSSCG00060019124; ENSSSCG00065037921; ENSSSCG00070011353; ENSSSUG00005004355; ENSSTOG00000014797; ENSSVLG00005024720; ENSTGEG00000001941; ENSTMTG00000013939; ENSVKKG00000006783; ENSVURG00010018277; ENSZALG00000007655; ENSZLMG00000002642" "Actb; ACTB; Actb_0; ACTL8; LOC101872991; LOC106497948; LOC111145734; LOC112063645; LOC117800408; LOC118142876; PS1TP5BP1" "A0A096NAA6; A0A098M1X5; A0A0B6VJU7; A0A0B8RRU9; A0A0B8RTY2; A0A1D9CFN7; A0A1S2ZVA4; A0A1S3FRD3; A0A1U7Q273; A0A1W7RJQ3; A0A218UWT5; A0A226NJ42; A0A250YGN4; A0A2D4GG12; A0A2J8KJN5; A0A2J8RAH6; A0A2K5CXD5; A0A2K5ZNV7; A0A2K6C9L8; A0A2K6JVX9; A0A2K6UUH3; A0A2P4SFV3; A0A2U3VHD6; A0A2U3XSJ3; A0A2Y9GE45; A0A2Y9JFQ8; A0A2Y9MFS3; A0A2Y9S868; A0A340WEU6; A0A341CY14; A0A384AHN3; A0A3Q7NCZ0; A0A452EGB1; A0A452GTY2; A0A4D9ENE9; A0A4W2DYQ2; A0A4X2LSI7; A0A5E4C6E9; A0A5J5MXV1; A0A5N3VUL9; A0A5N4CXK3; A0A663NBJ0; A0A667IZV1; A0A669QC85; A0A670YBF6; A0A671EW41; A0A672U7D6; A0A673TCM5; A0A674JEF6; A0A6B0SBF2; A0A6B2F1I3; A0A6B2FBI6; A0A6I9HGD1; A0A6J0H3K7; A0A6J0VYA4; A0A6J1Y0U5; A0A6J2ER79; A0A6J2G0V3; A0A6J2MYQ0; A0A6J3AFQ7; A0A6J3DTG2; A0A6J3GBY8; A0A6J3PXY9; A0A6P3QDF4; A0A6P5M7F0; A0A6P5PSI5; A0A6P9D9Q3; A0A7J7X8Z4; A0A7J8FJ79; A0A7J8I7K0; A0A7K4LHI1; A0A7K4PGF5; A0A7K4QS53; A0A7K4T128; A0A7K4TT29; A0A7K4VIP3; A0A7K4WM66; A0A7K4XNG5; A0A7K4Z9S9; A0A7K5AA34; A0A7K5AS89; A0A7K5BQ55; A0A7K5FSS5; A0A7K5H4P8; A0A7K5I2U8; A0A7K5K1W1; A0A7K5L347; A0A7K5MV66; A0A7K5NYG3; A0A7K5PUR4; A0A7K5QKD4; A0A7K5SEW2; A0A7K5SN56; A0A7K5UCA8; A0A7K5V0T3; A0A7K5W0A4; A0A7K5XZZ2; A0A7K5YRX7; A0A7K5ZQ33; A0A7K6AXY2; A0A7K6BYL2; A0A7K6FAZ8; A0A7K6H213; A0A7K6K8T2; A0A7K6M1I6; A0A7K6NUL4; A0A7K6QDF5; A0A7K6RH22; A0A7K6TM80; A0A7K6VD36; A0A7K6W7N1; A0A7K6X5J8; A0A7K6YU38; A0A7K7C2G9; A0A7K7EJS7; A0A7K7FS46; A0A7K7GD18; A0A7K7IBW8; A0A7K7K4W1; A0A7K7KKG3; A0A7K7MQH8; A0A7K7MV68; A0A7K7PD37; A0A7K7QM76; A0A7K7SE36; A0A7K7SKG2; A0A7K7VCN0; A0A7K7W887; A0A7K7XYY4; A0A7K7YKB8; A0A7K8CFW2; A0A7K8EJC7; A0A7K8FS78; A0A7K8G222; A0A7K8IUQ2; A0A7K8JZV4; A0A7K8LPI3; A0A7K8NBM6; A0A7K8PNA5; A0A7K8Q6L8; A0A7K8RIG2; A0A7K8SZY6; A0A7K8UAQ8; A0A7K8VV48; A0A7K8WC57; A0A7K8XP00; A0A7K8YCU6; A0A7K9A6Q1; A0A7K9CAW4; A0A7K9CTY4; A0A7K9E1U2; A0A7K9FBL7; A0A7K9GU20; A0A7K9HIF7; A0A7K9J0P9; A0A7K9JQ87; A0A7K9LVG6; A0A7K9R4T1; A0A7K9RUC2; A0A7K9T1K6; A0A7K9TJU9; A0A7K9VM54; A0A7K9W8F9; A0A7K9XJP5; A0A7K9YTX8; A0A7L0B981; A0A7L0CFC2; A0A7L0DK08; A0A7L0EE55; A0A7L0FB96; A0A7L0GQU8; A0A7L0IUJ7; A0A7L0K254; A0A7L0L680; A0A7L0MVK5; A0A7L0NBG6; A0A7L0Q6H1; A0A7L0RLK8; A0A7L0TBQ4; A0A7L0UF87; A0A7L0WJD4; A0A7L0ZXX6; A0A7L1D3E3; A0A7L1EEL1; A0A7L1EWI9; A0A7L1GDD0; A0A7L1I1H5; A0A7L1IUB6; A0A7L1K0S4; A0A7L1L6I1; A0A7L1MJS1; A0A7L1N7E9; A0A7L1QY43; A0A7L1R9N1; A0A7L1TFJ1; A0A7L1USL1; A0A7L1X2N1; A0A7L1YHH8; A0A7L1ZA36; A0A7L2AFK2; A0A7L2CBA6; A0A7L2DI04; A0A7L2E5K5; A0A7L2ETQ7; A0A7L2GZ90; A0A7L2HLP4; A0A7L2JI84; A0A7L2K9F9; A0A7L2LSR8; A0A7L2MKA1; A0A7L2NWG1; A0A7L2Q5Z6; A0A7L2TKF5; A0A7L2UQP2; A0A7L2WPM1; A0A7L3AB48; A0A7L3AEQ2; A0A7L3CBV1; A0A7L3GBT6; A0A7L3H4H6; A0A7L3I6Y5; A0A7L3KV16; A0A7L3L3C1; A0A7L3M5B9; A0A7L3NFE1; A0A7L3PPT4; A0A7L3QID2; A0A7L3RPI2; A0A7L3ST79; A0A7L3U378; A0A7L3VAR1; A0A7L3W396; A0A7L3X8C9; A0A7L3Z0M0; A0A7L4AJ46; A0A7L4BIP7; A0A7L4CC84; A0A7L4DQB0; A0A7L4EP40; A0A7L4HN55; A0A7L4J9W9; A0A7M4FIE6; A0A7N4PW14; A0A7T6ZK12; A0A811Z8F1; A0A850TFQ9; A0A850V5R2; A0A850W4N7; A0A850XKN3; A0A850YK23; A0A851A5U4; A0A851B4R4; A0A851CTC7; A0A851D320; A0A851E8C6; A0A851F1A8; A0A851JVZ7; A0A851K2P6; A0A851LU60; A0A851P5P0; A0A851R2P6; A0A851S6S6; A0A851T4V4; A0A851U0I3; A0A851VRP0; A0A851WCV5; A0A851Y321; A0A851Z9B4; A0A852A4Z3; A0A852AR86; A0A852BQ86; A0A852DLV7; A0A852E4W4; A0A852G2S2; A0A852L7H9; A0A852LWU6; A0A852MIU4; A0A852P924; A0A8B6ZZ93; A0A8B7FY80; A0A8B7JWS2; A0A8B7QXR8; A0A8B8VBY0; A0A8B9BC47; A0A8B9EY57; A0A8B9TCS0; A0A8C0BMH3; A0A8C0GIN8; A0A8C0IEG6; A0A8C0VMY6; A0A8C2VXZ2; A0A8C3I6V8; A0A8C3J5G4; A0A8C3QCS8; A0A8C3SWN5; A0A8C3V1H9; A0A8C4U9L8; A0A8C4W3F9; A0A8C5IQ83; A0A8C5L3Y8; A0A8C5UI70; A0A8C5Z473; A0A8C6AVT7; A0A8C6E309; A0A8C6J2B6; A0A8C7ELL8; A0A8C8AQ23; A0A8C8SAX1; A0A8C8TJI2; A0A8C9D802; A0A8C9EU06; A0A8C9HDT2; A0A8D0FEG6; A0A8D2DXS1; A0A8D2E312; A0A8D2J5F6; A0A8D2QDJ6; A0A8D2QMT1; A0A8I3W1I0; A0A8J4I2Z8; A0A8J4N6K5; A0A8J4NKS0; A0A8J4P196; A0A8J4U9Z8; A0A8K0BW04; A0A8K1GFZ5; A0A8M1G7Q7; A0A8S9EM85; A0A8V5H9G0; A0A973YLC1; A0A9F2R4N2; A0A9W2UUK2; A0A9W3F4H2; A0AA35L9Q0; A0AA40H6S4; A0AA40LS06; A5D961; A5PKA1; A6K1N6; aam:106497948; aful:116495117; aju:106984514; asn:102386754; B2RRX1; bacu:103015338; bom:102286048; bta:280979; ccan:109700700; cfa:403580; cfr:102514032; cpic:101941176; cpoc:100135470; cpoo:109314696; D5MU85; D7RIF5; dle:111170344; dord:105990935; ecb:100033878; elk:111145734; F6TIK4; F6UDX9; F7DIB7; fab:101813373; fca:101098507; G1MLH3; G3GVD0; G3QFP0; G8HY07; gfr:102041442; gga:396526; hai:109380220; hsa:60; I3MNL1; J3S3X5; J7H0T4; L5L2F8; L5LSF7; lav:100654618; lve:103077223; lww:102744309; M3WRZ7; M3YYU9; M7B7E7; maua:101844587; mcal:110295381; mcc:574285; mdo:100011313; mdo:100011351; mleu:105551087; mmu:11461; mmur:105868294; mni:105497365; mpuf:101686268; myd:102772396; nasi:112412020; nsu:110572001; O18840; oaa:100078865; oro:101375328; P02570; P60706; P60707; P60708; P60709; P60710; P60711; P60712; P60713; P70514; P99021; pale:102884469; panu:101026869; pbi:103050159; pcad:112063645; pcw:110223114; pdic:114509151; pgut:117676791; pon:100173832; ptr:450133; pvp:105294565; Q11209; Q11211; Q1KLZ0; Q25PW9; Q3SZD2; Q3TI89; Q3TVP6; Q4L0Y2; Q4R561; Q58J72; Q5R1X3; Q5R582; Q5R6G0; Q5W9H6; Q64316; Q6QAQ1; Q6ZWM3; Q711N9; Q71FK5; Q75MN2; Q76N69; Q8MIJ0; Q8SPX4; Q95164; Q96B34; Q96HG5; R0LHA7; ray:107515934; rbb:108538237; rno:81822; S9YTS3; sbq:101037287; shr:100919051; ssc:414396; T1DP26; U3FXK3; U3KHC4; umr:103670086; V9P8F4; vpc:102534524; zab:102067189; zca:113932833" "FAS pathway and stress induction of HSP regulation; Actin cytoskeleton regulation; Myometrial relaxation and contraction pathways; Focal adhesion; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; Pathogenic Escherichia coli infection; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Myometrial relaxation and contraction pathways; Regulation of actin cytoskeleton; Myometrial relaxation and contraction pathways; Ebola virus infection in host; Acute viral myocarditis; Thermogenesis; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Network map of SARS-CoV-2 signaling pathway; Regulation of actin cytoskeleton; Regulation of actin cytoskeleton; Focal adhesion" "EPH-ephrin mediated repulsion of cells; Formation of annular gap junctions; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; RHO GTPases Activate Formins; RHOF GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; B-WICH complex positively regulates rRNA expression; RHO GTPases Activate WASPs and WAVEs; UCH proteinases; DNA Damage Recognition in GG-NER; RHO GTPases activate IQGAPs; Cell-extracellular matrix interactions; MAP2K and MAPK activation; UCH proteinases; Clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases Activate Formins; RHOF GTPase cycle; MAP2K and MAPK activation; RHO GTPases Activate Formins; Clathrin-mediated endocytosis; RHOF GTPase cycle; DNA Damage Recognition in GG-NER; EPH-ephrin mediated repulsion of cells; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; Adherens junctions interactions; UCH proteinases; RHO GTPases Activate WASPs and WAVEs; B-WICH complex positively regulates rRNA expression; EPHB-mediated forward signaling; Formation of annular gap junctions; RHO GTPases activate IQGAPs; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; B-WICH complex positively regulates rRNA expression; Signaling by BRAF and RAF1 fusions; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; EPH-ephrin mediated repulsion of cells; HATs acetylate histones; Interaction between L1 and Ankyrins; Prefoldin mediated transfer of substrate to CCT/TriC; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Adherens junctions interactions; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Formation of annular gap junctions; Folding of actin by CCT/TriC; Cell-extracellular matrix interactions; Regulation of actin dynamics for phagocytic cup formation; Interaction between L1 and Ankyrins; DNA Damage Recognition in GG-NER; MAP2K and MAPK activation; RHO GTPases Activate Formins; Recycling pathway of L1; RHO GTPases activate IQGAPs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; UCH proteinases; B-WICH complex positively regulates rRNA expression; Adherens junctions interactions; RHOF GTPase cycle; Formation of annular gap junctions; VEGFA-VEGFR2 Pathway; Cell-extracellular matrix interactions; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; Regulation of actin dynamics for phagocytic cup formation; UCH proteinases; B-WICH complex positively regulates rRNA expression; DNA Damage Recognition in GG-NER; RHO GTPases Activate Formins; Interaction between L1 and Ankyrins; RHOF GTPase cycle; Adherens junctions interactions; VEGFA-VEGFR2 Pathway; RHO GTPases Activate WASPs and WAVEs; Cell-extracellular matrix interactions; EPHB-mediated forward signaling; MAP2K and MAPK activation; Recycling pathway of L1; RHO GTPases activate IQGAPs; Formation of annular gap junctions; B-WICH complex positively regulates rRNA expression; UCH proteinases; MAP2K and MAPK activation; RHO GTPases Activate Formins; Regulation of actin dynamics for phagocytic cup formation; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway; Clathrin-mediated endocytosis; EPHB-mediated forward signaling; DNA Damage Recognition in GG-NER; RHOF GTPase cycle; Cell-extracellular matrix interactions; Adherens junctions interactions; RHO GTPases activate IQGAPs; Gap junction degradation; Formation of annular gap junctions; Regulation of actin dynamics for phagocytic cup formation; RHOF GTPase cycle; Clathrin-mediated endocytosis; RHO GTPases Activate Formins; Cell-extracellular matrix interactions; VEGFA-VEGFR2 Pathway; UCH proteinases; Adherens junctions interactions; RHO GTPases activate IQGAPs; EPHB-mediated forward signaling; MAP2K and MAPK activation; RHO GTPases Activate WASPs and WAVEs; Formation of annular gap junctions" "157" "21" "1.007" "1.052" "1.031" "0.997" "1.011" "0.973" "1.020" "1.052" "0.881" "76571.0" "77123.6" "80547.0" "78961.4" "76354.0" "77450.7" "74468.9" "78115.9" "80583.2" "67438.4" "" "" "" "" "" "" "" "" "" "" "68844.8" "62405.7" "72857.4" "77077.3" "63008.7" "77450.7" "55760.4" "68997.1" "72105.2" "24073.6" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6514754949609892250" "False" "High" "IsMasterProtein" "Q9UQE7" "Structural maintenance of chromosomes protein 3 OS=Homo sapiens OX=9606 GN=SMC3 PE=1 SV=2" "0.000" "False" "334.321" "48" "62" "124" "61" "1217" "141.5" "7.18" "478.55" "62" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "9126" "ENSG00000108055" "SMC3" "A8K156; hsa:9126; O60464; Q5T482; Q9UQE7" "Cell cycle; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "SUMOylation of DNA damage response and repair proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "15" "0" "0.989" "1.003" "0.978" "0.998" "0.991" "0.955" "1.001" "0.995" "0.868" "11741.7" "11609.2" "11775.7" "11480.4" "11714.1" "11637.0" "11213.5" "11749.6" "11682.3" "10191.0" "" "" "" "" "" "" "" "" "" "" "10556.9" "9393.7" "10651.5" "11206.5" "9666.7" "11637.0" "8396.4" "10378.0" "10453.3" "3637.9" "61" "61" "61" "61" "61" "61" "61" "61" "61" "61" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1213395878895108528" "False" "High" "IsMasterProtein" "P26038" "Moesin OS=Homo sapiens OX=9606 GN=MSN PE=1 SV=3" "0.000" "False" "327.247" "73" "54" "231" "40" "577" "67.8" "6.40" "747.78" "54" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4478" "ENSG00000147065" "MSN" "hsa:4478; P26038" "Glial cell differentiation; AGE/RAGE pathway; Measles virus infection; 16p11.2 proximal deletion syndrome; Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by ALK fusions and activated point mutants" "10" "17" "1.012" "0.966" "1.080" "0.963" "0.997" "0.978" "1.037" "0.961" "0.789" "18636.1" "18866.3" "18008.6" "20120.4" "17954.4" "18579.9" "18217.5" "19321.4" "17917.3" "14699.7" "" "" "" "" "" "" "" "" "" "" "16755.7" "15266.0" "16289.4" "19640.3" "14816.3" "18579.9" "13640.8" "17065.9" "16032.2" "5247.4" "61" "61" "61" "61" "61" "61" "61" "61" "61" "61" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3002712347046388220" "False" "High" "IsMasterProtein" "P78371" "T-complex protein 1 subunit beta OS=Homo sapiens OX=9606 GN=CCT2 PE=1 SV=4" "0.000" "False" "325.067" "78" "35" "203" "35" "535" "57.5" "6.46" "776.12" "35" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10576" "ENSG00000166226" "CCT2" "A8K402; B5BTY7; B7Z243; B7Z7K4; B7ZAT2; hsa:10576; P78371; Q14D36; Q6IAT3" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC; BBSome-mediated cargo-targeting to cilium; RHOBTB1 GTPase cycle" "10" "0" "1.005" "0.966" "1.006" "0.976" "0.970" "0.990" "1.008" "0.999" "0.852" "16003.9" "16083.0" "15464.6" "16105.1" "15626.1" "15519.3" "15848.1" "16133.7" "15981.2" "13637.0" "" "" "" "" "" "" "" "" "" "" "14389.1" "13013.8" "13988.3" "15720.8" "12894.9" "15519.3" "11866.6" "14250.4" "14299.9" "4868.0" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8215909947984891721" "False" "High" "IsMasterProtein" "P27816" "Microtubule-associated protein 4 OS=Homo sapiens OX=9606 GN=MAP4 PE=1 SV=3" "0.000" "False" "323.744" "49" "49" "156" "49" "1152" "120.9" "5.43" "546.88" "49" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418" "4134" "ENSG00000047849" "MAP4" "P27816; Q13082; Q59FT2; Q68D74; Q6ZUW9; Q86V26; Q96A76; Q96NS9" "Splicing factor NOVA regulated synaptic proteins; 2q37 copy number variation syndrome" "" "2" "0" "0.963" "0.953" "0.985" "0.956" "0.974" "0.970" "1.008" "0.930" "0.787" "15252.2" "14682.5" "14531.8" "15028.4" "14580.6" "14860.7" "14789.5" "15368.9" "14177.9" "12009.9" "" "" "" "" "" "" "" "" "" "" "13713.2" "11880.5" "13144.5" "14669.8" "12032.2" "14860.7" "11074.0" "13574.8" "12686.3" "4287.2" "59" "59" "59" "59" "59" "59" "59" "59" "59" "59" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5561612098835552022" "False" "High" "IsMasterProtein" "P38646" "Stress-70 protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPA9 PE=1 SV=2" "0.000" "False" "322.985" "65" "42" "199" "41" "679" "73.6" "6.16" "748.37" "42" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3313" "ENSG00000113013" "HSPA9" "B2RCM1; hsa:3313; P30036; P31932; P38646; Q1HB43; Q53H23; Q6GU03; Q9BWB7; Q9UC56" "Parkin-ubiquitin proteasomal system pathway; Iron-sulfur cluster biogenesis" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Mitochondrial protein degradation; Mitochondrial protein import; Regulation of HSF1-mediated heat shock response; Cristae formation" "7" "1" "1.041" "1.037" "1.045" "1.016" "1.043" "1.011" "1.075" "1.012" "0.835" "19905.5" "20714.3" "20651.7" "20800.3" "20219.7" "20766.8" "20114.6" "21398.6" "20142.0" "16615.6" "" "" "" "" "" "" "" "" "" "" "17897.0" "16761.3" "18680.2" "20304.0" "16685.7" "20766.8" "15061.3" "18900.6" "18022.9" "5931.3" "49" "49" "49" "49" "49" "49" "49" "49" "49" "49" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6866488294459179487" "False" "High" "IsMasterProtein" "Q8NFC6" "Biorientation of chromosomes in cell division protein 1-like 1 OS=Homo sapiens OX=9606 GN=BOD1L1 PE=1 SV=2" "0.000" "False" "322.539" "30" "72" "100" "71" "3051" "330.3" "5.08" "391.70" "72" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf05205" "259282" "ENSG00000038219" "BOD1L1" "hsa:259282; Q6P0M8; Q8NFC6; Q96AL1; Q9H6G0; Q9NTD6; Q9P2L9" "" "Formation of WDR5-containing histone-modifying complexes" "1" "1" "0.989" "0.950" "1.024" "1.009" "0.996" "1.006" "1.027" "0.975" "0.833" "8178.5" "8092.4" "7768.8" "8376.9" "8255.8" "8147.6" "8230.7" "8396.9" "7972.6" "6813.8" "" "" "" "" "" "" "" "" "" "" "7353.3" "6548.1" "7027.1" "8177.1" "6812.8" "8147.6" "6162.9" "7416.6" "7133.8" "2432.3" "64" "64" "64" "64" "64" "64" "64" "64" "64" "64" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7379954125319751521" "False" "High" "IsMasterProtein" "P48643" "T-complex protein 1 subunit epsilon OS=Homo sapiens OX=9606 GN=CCT5 PE=1 SV=1" "0.000" "False" "320.945" "77" "39" "204" "38" "541" "59.6" "5.66" "770.93" "39" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00118" "22948" "ENSG00000150753" "CCT5" "A8JZY8; A8K2X8; B4DYD8; hsa:22948; P48643" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "1" "1.017" "0.999" "1.003" "0.996" "0.977" "0.992" "1.013" "1.004" "0.788" "19048.7" "19369.2" "19024.2" "19106.3" "18970.5" "18617.1" "18905.1" "19300.2" "19125.2" "15007.6" "" "" "" "" "" "" "" "" "" "" "17126.6" "15672.8" "17208.0" "18650.4" "15654.8" "18617.1" "14155.7" "17047.2" "17113.1" "5357.3" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3650651295291502810" "False" "High" "IsMasterProtein" "O75369" "Filamin-B OS=Homo sapiens OX=9606 GN=FLNB PE=1 SV=2" "0.000" "False" "320.399" "33" "73" "109" "67" "2602" "278.0" "5.73" "402.51" "73" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00630" "2317" "ENSG00000136068" "FLNB" "B2ZZ83; B2ZZ84; B2ZZ85; C9JKE6; C9JMC4; hsa:2317; O75369; Q13706; Q59EC2; Q60FE7; Q6MZJ1; Q8WXS9; Q8WXT0; Q8WXT1; Q8WXT2; Q8WXT3; Q9NRB5; Q9NT26; Q9UEV9" "Focal adhesion; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Ebola virus infection in host; NPHP1 deletion syndrome" "ISG15 antiviral mechanism" "6" "0" "1.010" "1.172" "1.012" "1.031" "1.148" "0.995" "1.014" "1.188" "0.912" "6946.5" "7016.5" "8143.5" "7027.2" "7162.5" "7975.2" "6912.4" "7044.3" "8249.9" "6336.5" "" "" "" "" "" "" "" "" "" "" "6245.6" "5677.5" "7366.0" "6859.5" "5910.7" "7975.2" "5175.8" "6222.0" "7382.0" "2261.9" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3490068427957957642" "False" "High" "IsMasterProtein" "P49588" "Alanine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=AARS1 PE=1 SV=2" "0.000" "False" "320.294" "55" "44" "137" "44" "968" "106.7" "5.53" "526.22" "44" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01411, Pf02272, Pf07973" "16" "ENSG00000090861" "AARS1" "A6NF14; B4DR45; hsa:16; P49588; Q53GV7; Q96FA0" "IL-18 signaling pathway" "Cytosolic tRNA aminoacylation" "2" "0" "1.015" "1.004" "1.004" "0.997" "0.999" "0.984" "1.008" "0.999" "0.917" "14580.1" "14799.6" "14632.2" "14645.5" "14539.2" "14561.2" "14343.2" "14693.1" "14563.7" "13368.4" "" "" "" "" "" "" "" "" "" "" "13108.9" "11975.3" "13235.3" "14296.1" "11998.0" "14561.2" "10739.8" "12977.9" "13031.5" "4772.2" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5579729439990208910" "False" "High" "IsMasterProtein" "P06733" "Alpha-enolase OS=Homo sapiens OX=9606 GN=ENO1 PE=1 SV=2" "0.000" "False" "319.022" "79" "34" "376" "16" "434" "47.1" "7.39" "1484.68" "34" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00113, Pf03952" "2023" "ENSG00000074800" "ENO1" "B2RD59; hsa:2023; P06733; P22712; Q16704; Q4TUS4; Q53FT9; Q53HR3; Q658M5; Q6GMP2; Q71V37; Q7Z3V6; Q8WU71; Q96GV1; Q9BT62; Q9UCH6; Q9UM55" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; IL-18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "9" "20" "1.033" "0.977" "1.187" "0.976" "0.995" "1.000" "1.005" "0.991" "0.816" "32446.0" "33519.2" "31701.8" "38512.2" "31683.4" "32286.5" "32433.6" "32620.5" "32161.0" "26479.1" "" "" "" "" "" "" "" "" "" "" "29172.1" "27122.5" "28675.3" "37593.2" "26145.7" "32286.5" "24285.5" "28812.5" "28777.4" "9452.3" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1034815253104013464" "False" "High" "IsMasterProtein" "P50990" "T-complex protein 1 subunit theta OS=Homo sapiens OX=9606 GN=CCT8 PE=1 SV=4" "0.000" "False" "318.735" "77" "39" "206" "39" "548" "59.6" "5.60" "749.55" "39" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00118" "10694" "ENSG00000156261; ENSG00000291533" "CCT8" "A6NN54; B4DEM7; B4DQH4; hsa:10694; P50990; Q4VBP8" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation; Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "0.985" "1.021" "0.998" "0.975" "0.957" "0.966" "0.981" "1.000" "0.775" "19357.1" "19065.1" "19754.4" "19327.3" "18875.0" "18520.9" "18689.3" "18994.9" "19348.9" "14998.2" "" "" "" "" "" "" "" "" "" "" "17403.9" "15426.8" "17868.5" "18866.1" "15576.0" "18520.9" "13994.1" "16777.5" "17313.2" "5353.9" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8533826193911874289" "False" "High" "IsMasterProtein" "Q86VP6" "Cullin-associated NEDD8-dissociated protein 1 OS=Homo sapiens OX=9606 GN=CAND1 PE=1 SV=2" "0.000" "False" "318.399" "46" "50" "167" "49" "1230" "136.3" "5.78" "610.84" "50" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08623, Pf13513" "55832" "ENSG00000111530" "CAND1" "B2RAU3; hsa:55832; O94918; Q6PIY4; Q86VP6; Q8NDJ4; Q96JZ9; Q96T19; Q9BTC4; Q9H0G2; Q9P0H7; Q9UF85" "Endoderm differentiation" "Neutrophil degranulation; Neddylation; Iron uptake and transport" "4" "2" "1.033" "1.026" "1.006" "1.014" "1.000" "1.002" "1.013" "1.035" "0.760" "14830.6" "15315.7" "15212.2" "14926.6" "15033.3" "14835.9" "14862.5" "15029.0" "15344.8" "11267.4" "" "" "" "" "" "" "" "" "" "" "13334.1" "12392.9" "13759.9" "14570.4" "12405.7" "14835.9" "11128.7" "13274.6" "13730.4" "4022.1" "54" "54" "54" "54" "54" "54" "54" "54" "54" "54" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1011353078992681906" "False" "High" "IsMasterProtein" "P49736" "DNA replication licensing factor MCM2 OS=Homo sapiens OX=9606 GN=MCM2 PE=1 SV=4" "0.000" "False" "313.728" "53" "41" "156" "41" "904" "101.8" "5.52" "599.55" "41" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf12619, Pf14551, Pf17207, Pf17855" "4171" "ENSG00000073111" "MCM2" "hsa:4171; P49736; Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication; 1p36 copy number variation syndrome" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.023" "1.020" "0.980" "1.037" "0.986" "1.037" "1.014" "1.005" "0.891" "12278.8" "12560.7" "12530.4" "12034.5" "12728.9" "12112.2" "12735.0" "12450.6" "12336.8" "10942.0" "" "" "" "" "" "" "" "" "" "" "11039.8" "10163.7" "11334.1" "11747.3" "10504.2" "12112.2" "9535.6" "10997.2" "11038.9" "3906.0" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4357852675593899782" "False" "High" "IsMasterProtein" "P25205" "DNA replication licensing factor MCM3 OS=Homo sapiens OX=9606 GN=MCM3 PE=1 SV=3" "0.000" "False" "313.073" "66" "50" "168" "50" "808" "90.9" "5.77" "568.32" "50" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4172" "ENSG00000112118" "MCM3" "B4DWW4; hsa:4172; P25205; Q92660; Q9BTR3; Q9NUE7" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.017" "1.043" "1.059" "1.015" "1.036" "1.006" "1.024" "1.072" "0.945" "12049.8" "12256.3" "12565.7" "12755.7" "12236.5" "12477.6" "12123.8" "12338.8" "12913.0" "11391.6" "" "" "" "" "" "" "" "" "" "" "10834.0" "9917.3" "11366.1" "12451.3" "10097.8" "12477.6" "9078.0" "10898.4" "11554.5" "4066.5" "53" "53" "53" "53" "53" "53" "53" "53" "53" "53" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1414691960117410819" "False" "High" "IsMasterProtein" "P33991" "DNA replication licensing factor MCM4 OS=Homo sapiens OX=9606 GN=MCM4 PE=1 SV=5" "0.000" "False" "311.049" "61" "47" "148" "47" "863" "96.5" "6.74" "591.89" "47" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf21128" "4173" "ENSG00000104738" "MCM4" "hsa:4173; P33991; Q8NEH1; Q99658" "Cell cycle; Gastric cancer network 1; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.035" "1.030" "1.031" "1.021" "1.046" "1.015" "1.019" "1.058" "0.929" "11880.7" "12293.6" "12235.0" "12253.1" "12132.5" "12429.8" "12054.8" "12108.1" "12566.2" "11040.5" "" "" "" "" "" "" "" "" "" "" "10681.9" "9947.6" "11066.9" "11960.7" "10012.0" "12429.8" "9026.3" "10694.7" "11244.1" "3941.2" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8676466481375871245" "False" "High" "IsMasterProtein" "P08133" "Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3" "0.000" "False" "310.716" "70" "49" "206" "49" "673" "75.8" "5.60" "722.07" "49" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00191" "309" "ENSG00000197043" "ANXA6" "B7Z8A7; D3DQH4; E9PGK1; hsa:309; P08133; Q6ZT79" "Calcium regulation in cardiac cells; Prostaglandin synthesis and regulation" "Smooth Muscle Contraction" "3" "0" "1.017" "1.007" "1.028" "1.035" "0.990" "1.038" "1.030" "0.988" "0.915" "17368.7" "17661.3" "17481.8" "17860.0" "17984.0" "17188.8" "18029.7" "17897.2" "17157.3" "15900.9" "" "" "" "" "" "" "" "" "" "" "15616.2" "14290.9" "15812.9" "17433.9" "14840.7" "17188.8" "13500.2" "15808.0" "15352.2" "5676.2" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3348063048302493190" "False" "High" "IsMasterProtein" "P50851" "Lipopolysaccharide-responsive and beige-like anchor protein OS=Homo sapiens OX=9606 GN=LRBA PE=1 SV=4" "0.000" "False" "310.546" "29" "67" "106" "67" "2863" "318.9" "5.60" "404.15" "67" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf02138, Pf06469, Pf13385, Pf14844, Pf15787, Pf20425, Pf20426" "987" "ENSG00000198589" "LRBA" "hsa:987; P50851; Q4W5J4; Q4W5L6; Q8NFQ0; Q9H2U3; Q9H2U4" "" "" "0" "0" "1.045" "1.009" "0.974" "1.046" "0.947" "1.014" "0.985" "1.013" "1.052" "7647.6" "7991.4" "7714.7" "7449.2" "7995.7" "7243.2" "7751.8" "7536.3" "7750.1" "8047.3" "" "" "" "" "" "" "" "" "" "" "6875.9" "6466.4" "6978.2" "7271.4" "6598.2" "7243.2" "5804.3" "6656.5" "6934.8" "2872.7" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562319574892213792" "False" "High" "IsMasterProtein" "P04406" "Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens OX=9606 GN=GAPDH PE=1 SV=3" "0.000" "False" "308.088" "73" "27" "607" "27" "335" "36.0" "8.46" "2351.34" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00044, Pf02800" "2597" "ENSG00000111640" "GAPDH" "E7EUT4; hsa:2597; P00354; P04406; Q53X65" "Cori cycle; Alzheimer's disease and miRNA effects; HIF1A and PPARG regulation of glycolysis; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; 7q11.23 copy number variation syndrome; Glycolysis in senescence; Alzheimer's disease; Sildenafil treatment; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glycolysis; Gluconeogenesis" "16" "0" "1.023" "0.968" "1.131" "0.960" "0.998" "0.999" "1.010" "1.008" "0.815" "44003.4" "45011.6" "42596.3" "49755.0" "42263.9" "43896.0" "43954.9" "44442.1" "44369.8" "35852.3" "" "" "" "" "" "" "" "" "" "" "39563.4" "36421.8" "38529.8" "48567.8" "34876.9" "43896.0" "32912.4" "39254.2" "39701.7" "12798.3" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1119286615561917853" "False" "High" "IsMasterProtein" "P00558" "Phosphoglycerate kinase 1 OS=Homo sapiens OX=9606 GN=PGK1 PE=1 SV=3" "0.000" "False" "307.573" "87" "36" "261" "30" "417" "44.6" "8.10" "1004.81" "36" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol" "kinase activity;other molecular function" "Pf00162" "5230" "ENSG00000102144" "PGK1" "A8K4W6; B7Z7A9; hsa:5230; P00558; Q5J7W1; Q6IBT6; Q8NI87" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Manipulation of host energy metabolism" "13" "6" "1.009" "0.995" "1.073" "0.985" "1.023" "0.999" "1.010" "1.006" "0.758" "26930.8" "27160.6" "26802.0" "28904.0" "26522.4" "27560.0" "26899.0" "27193.4" "27090.4" "20411.9" "" "" "" "" "" "" "" "" "" "" "24213.4" "21977.4" "24243.3" "28214.3" "21886.8" "27560.0" "20141.3" "24019.0" "24240.3" "7286.5" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3757999433169180156" "False" "High" "IsMasterProtein" "Q9NTJ3" "Structural maintenance of chromosomes protein 4 OS=Homo sapiens OX=9606 GN=SMC4 PE=1 SV=2" "0.000" "False" "307.504" "45" "52" "124" "52" "1288" "147.1" "6.79" "488.14" "52" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10051" "ENSG00000113810" "SMC4" "A6NLT9; D3DNL8; hsa:10051; O95752; Q8NDL4; Q9NTJ3; Q9UNT9" "Ciliary landscape" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.041" "1.016" "0.988" "1.015" "0.965" "1.020" "1.007" "1.001" "1.128" "11516.4" "11989.1" "11699.1" "11376.9" "11685.0" "11117.4" "11745.8" "11595.2" "11523.2" "12987.2" "" "" "" "" "" "" "" "" "" "" "10354.4" "9701.1" "10582.2" "11105.5" "9642.6" "11117.4" "8794.9" "10241.6" "10310.9" "4636.0" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7448021442665095265" "False" "High" "IsMasterProtein" "O95347" "Structural maintenance of chromosomes protein 2 OS=Homo sapiens OX=9606 GN=SMC2 PE=1 SV=2" "0.000" "False" "307.410" "48" "61" "125" "61" "1197" "135.6" "8.43" "476.37" "61" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463, Pf06470" "10592" "ENSG00000136824" "SMC2" "hsa:10592; O95347; Q6IEE0; Q9P1P2" "Retinoblastoma gene in cancer" "Condensation of Prophase Chromosomes; Condensation of Prometaphase Chromosomes" "3" "0" "1.015" "1.006" "1.011" "1.015" "0.977" "1.027" "1.025" "1.022" "1.143" "12482.2" "12672.4" "12553.5" "12614.4" "12672.5" "12193.4" "12824.1" "12794.1" "12750.8" "14271.7" "" "" "" "" "" "" "" "" "" "" "11222.7" "10254.1" "11355.1" "12313.4" "10457.5" "12193.4" "9602.4" "11300.6" "11409.3" "5094.6" "56" "56" "56" "56" "56" "56" "56" "56" "56" "56" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4874670657009698466" "False" "High" "IsMasterProtein" "Q6P2Q9" "Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens OX=9606 GN=PRPF8 PE=1 SV=2" "0.000" "False" "306.637" "34" "71" "109" "71" "2335" "273.4" "8.84" "372.86" "71" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01398, Pf08082, Pf08083, Pf08084, Pf10596, Pf10597, Pf10598, Pf12134" "10594" "ENSG00000174231; ENSG00000274442" "PRPF8" "hsa:10594; O14547; O75965; Q6P2Q9" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.977" "0.945" "0.877" "0.953" "0.944" "0.919" "0.875" "0.897" "0.943" "7295.4" "7125.5" "6896.0" "6397.0" "6954.3" "6883.3" "6702.2" "6386.2" "6547.1" "6880.4" "" "" "" "" "" "" "" "" "" "" "6559.3" "5765.7" "6237.7" "6244.4" "5738.8" "6883.3" "5018.4" "5640.7" "5858.3" "2456.1" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8012908085941337264" "False" "High" "IsMasterProtein" "Q99832" "T-complex protein 1 subunit eta OS=Homo sapiens OX=9606 GN=CCT7 PE=1 SV=2" "0.000" "False" "305.289" "74" "38" "183" "38" "543" "59.3" "7.65" "732.63" "38" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "10574" "ENSG00000135624" "CCT7" "A8K7E6; A8MWI8; B7WNW9; B7Z4T9; B7Z4Z7; hsa:10574; O14871; Q6FI26; Q99832" "VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; RHOBTB1 GTPase cycle; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "9" "0" "1.023" "1.015" "1.009" "0.964" "0.990" "0.970" "0.985" "1.017" "0.815" "15011.4" "15361.6" "15230.8" "15142.8" "14465.2" "14868.1" "14556.8" "14787.3" "15263.7" "12240.1" "" "" "" "" "" "" "" "" "" "" "13496.7" "12430.1" "13776.8" "14781.5" "11936.9" "14868.1" "10899.8" "13061.1" "13657.9" "4369.4" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "627927697280554035" "False" "High" "IsMasterProtein" "O60841" "Eukaryotic translation initiation factor 5B OS=Homo sapiens OX=9606 GN=EIF5B PE=1 SV=4" "0.000" "False" "305.266" "40" "50" "124" "49" "1220" "138.7" "5.49" "476.22" "50" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf11987, Pf14578" "9669" "ENSG00000158417" "EIF5B" "hsa:9669; O60841; O95805; Q53RV7; Q53SI8; Q9UF81; Q9UMN7" "Translation factors; Ciliary landscape" "GTP hydrolysis and joining of the 60S ribosomal subunit" "3" "0" "0.971" "0.988" "0.924" "0.960" "0.984" "0.953" "0.955" "0.942" "0.865" "13995.6" "13590.2" "13827.4" "12935.3" "13429.6" "13777.2" "13338.9" "13364.3" "13181.7" "12111.0" "" "" "" "" "" "" "" "" "" "" "12583.4" "10996.7" "12507.3" "12626.6" "11082.3" "13777.2" "9987.8" "11804.3" "11794.9" "4323.3" "51" "51" "51" "51" "51" "51" "51" "51" "51" "51" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5949671281598126574" "False" "High" "IsMasterProtein" "Q13464" "Rho-associated protein kinase 1 OS=Homo sapiens OX=9606 GN=ROCK1 PE=1 SV=1" "0.000" "False" "304.963" "46" "61" "114" "54" "1354" "158.1" "5.90" "432.64" "61" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "6093" "ENSG00000067900" "ROCK1" "B0YJ91; hsa:6093; Q13464; Q2KHM4; Q59GZ4" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Focal adhesion; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Gastrin signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; EPHB-mediated forward signaling; Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; RND3 GTPase cycle; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle; Apoptotic cleavage of cellular proteins" "35" "7" "0.997" "0.948" "0.982" "0.985" "0.919" "0.978" "0.970" "0.938" "0.946" "12709.8" "12666.0" "12053.1" "12474.8" "12513.5" "11681.9" "12429.6" "12326.0" "11921.7" "12023.9" "" "" "" "" "" "" "" "" "" "" "11427.4" "10248.9" "10902.4" "12177.1" "10326.4" "11681.9" "9307.0" "10887.2" "10667.4" "4292.2" "57" "57" "57" "57" "57" "57" "57" "57" "57" "57" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3927890985374291245" "False" "High" "IsMasterProtein" "P11586" "C-1-tetrahydrofolate synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=MTHFD1 PE=1 SV=4" "0.000" "False" "302.440" "50" "44" "129" "43" "935" "101.5" "7.30" "506.74" "44" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "4522" "ENSG00000100714" "MTHFD1" "A0A024R652; A0A384N5Y3; B2R5Y2; G3V2B8; hsa:4522; P11586; Q86VC9; Q9BVP5" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Male infertility; Spina bifida" "Metabolism of folate and pterines" "6" "1" "0.991" "0.988" "0.973" "0.968" "0.968" "0.954" "0.978" "1.004" "0.799" "13899.6" "13769.0" "13737.2" "13518.3" "13459.6" "13458.7" "13254.8" "13589.0" "13953.9" "11100.5" "" "" "" "" "" "" "" "" "" "" "12497.1" "11141.4" "12425.7" "13195.8" "11107.1" "13458.7" "9924.8" "12002.7" "12485.9" "3962.6" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418914028943411131" "False" "High" "IsMasterProtein" "P29144" "Tripeptidyl-peptidase 2 OS=Homo sapiens OX=9606 GN=TPP2 PE=1 SV=4" "0.000" "False" "299.295" "56" "56" "126" "56" "1249" "138.3" "6.32" "474.06" "56" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00082, Pf12580, Pf12583, Pf21223, Pf21316" "7174" "ENSG00000134900" "TPP2" "hsa:7174; P29144; Q5VZU8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.011" "1.008" "0.982" "1.002" "0.962" "1.000" "0.985" "0.999" "0.828" "12661.3" "12799.6" "12763.5" "12435.9" "12690.9" "12185.2" "12666.7" "12468.8" "12643.8" "10489.0" "" "" "" "" "" "" "" "" "" "" "11383.7" "10357.0" "11545.0" "12139.2" "10472.7" "12185.2" "9484.5" "11013.2" "11313.6" "3744.3" "49" "49" "49" "49" "49" "49" "49" "49" "49" "49" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625337675714682058" "False" "High" "IsMasterProtein" "P33176" "Kinesin-1 heavy chain OS=Homo sapiens OX=9606 GN=KIF5B PE=1 SV=1" "0.000" "False" "293.921" "57" "50" "112" "37" "963" "109.6" "6.51" "419.67" "50" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3799" "ENSG00000170759" "KIF5B" "A0AVB2; hsa:3799; P33176; Q5VZ85" "Alzheimer's disease and miRNA effects; Envelope proteins and their potential roles in EDMD physiopathology; Insulin signaling; CCL18 signaling pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Signaling by ALK fusions and activated point mutants; Insulin processing; RHO GTPases activate KTN1" "11" "8" "1.030" "0.978" "1.010" "1.009" "0.966" "0.996" "1.026" "0.993" "0.835" "9550.4" "9835.2" "9342.9" "9643.0" "9634.5" "9228.8" "9511.1" "9795.4" "9484.4" "7976.4" "" "" "" "" "" "" "" "" "" "" "8586.7" "7958.3" "8451.0" "9412.9" "7950.6" "9228.8" "7121.7" "8651.9" "8486.6" "2847.4" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2426861074950700078" "False" "High" "IsMasterProtein" "P22314" "Ubiquitin-like modifier-activating enzyme 1 OS=Homo sapiens OX=9606 GN=UBA1 PE=1 SV=3" "0.000" "False" "293.396" "50" "40" "162" "40" "1058" "117.8" "5.76" "648.99" "40" "protein metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "7317" "ENSG00000130985" "UBA1" "hsa:7317; P22314; Q5JRR8; Q96E13" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "0.964" "0.899" "0.991" "0.926" "0.872" "0.985" "0.900" "0.847" "1.022" "14177.1" "13666.0" "12745.7" "14053.9" "13132.2" "12360.2" "13969.2" "12766.1" "12004.3" "14495.5" "" "" "" "" "" "" "" "" "" "" "12746.6" "11058.1" "11528.9" "13718.5" "10837.0" "12360.2" "10459.8" "11275.8" "10741.3" "5174.5" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8891268094734712955" "False" "High" "IsMasterProtein" "Q13428" "Treacle protein OS=Homo sapiens OX=9606 GN=TCOF1 PE=1 SV=3" "0.000" "False" "288.874" "37" "57" "124" "57" "1488" "152.0" "9.04" "411.90" "57" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03546" "6949" "ENSG00000070814" "TCOF1" "A0JLU0; B4E111; hsa:6949; Q13428; Q6SC72; Q7Z5W9; Q96A52; Q99408; Q99860" "" "" "0" "0" "0.991" "0.953" "0.959" "0.961" "0.984" "0.952" "0.999" "0.912" "0.856" "10179.6" "10083.0" "9704.0" "9762.7" "9785.6" "10015.0" "9690.5" "10174.1" "9286.5" "8717.4" "" "" "" "" "" "" "" "" "" "" "9152.5" "8158.8" "8777.6" "9529.8" "8075.2" "10015.0" "7256.0" "8986.4" "8309.5" "3111.9" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6942352143814958774" "False" "High" "IsMasterProtein" "P49368" "T-complex protein 1 subunit gamma OS=Homo sapiens OX=9606 GN=CCT3 PE=1 SV=4" "0.000" "False" "288.119" "67" "41" "163" "41" "545" "60.5" "6.49" "612.58" "41" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "7203" "ENSG00000163468" "CCT3" "A6NE14; hsa:7203; P49368; Q5SZY1; Q9BR64" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "1.003" "0.975" "1.034" "0.969" "0.974" "0.992" "1.002" "0.998" "0.844" "15123.3" "15168.1" "14749.6" "15633.9" "14655.2" "14728.0" "14999.1" "15153.5" "15085.5" "12758.3" "" "" "" "" "" "" "" "" "" "" "13597.4" "12273.5" "13341.5" "15260.9" "12093.7" "14728.0" "11231.0" "13384.5" "13498.4" "4554.3" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3959572878681588940" "False" "High" "IsMasterProtein" "P17987" "T-complex protein 1 subunit alpha OS=Homo sapiens OX=9606 GN=TCP1 PE=1 SV=1" "0.000" "False" "287.213" "63" "31" "174" "31" "556" "60.3" "6.11" "666.84" "31" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00118" "6950" "ENSG00000120438" "TCP1" "E1P5B2; hsa:6950; P17987; Q15556; Q5TCM3" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "8" "0" "1.016" "0.995" "1.003" "0.995" "0.967" "0.996" "1.003" "1.023" "0.827" "17409.8" "17687.3" "17316.1" "17459.6" "17320.8" "16841.3" "17347.1" "17460.8" "17818.1" "14401.0" "" "" "" "" "" "" "" "" "" "" "15653.1" "14312.0" "15663.0" "17043.0" "14293.4" "16841.3" "12989.0" "15422.5" "15943.5" "5140.7" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2327422208095163378" "False" "High" "IsMasterProtein" "P35749" "Myosin-11 OS=Homo sapiens OX=9606 GN=MYH11 PE=1 SV=3" "0.000" "False" "285.983" "32" "59" "115" "39" "1972" "227.2" "5.50" "425.44" "59" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "4629" "ENSG00000133392; ENSG00000276480" "MYH11" "D2JYH7; hsa:4629; O00396; O94944; P35749; P78422; Q3MIV8; Q3MNF0; Q3MNF1" "VEGFA-VEGFR2 signaling" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "1.034" "1.204" "0.982" "1.077" "1.224" "1.049" "1.043" "1.203" "1.053" "2840.2" "2936.4" "3420.7" "2789.4" "3060.0" "3475.5" "2978.6" "2961.6" "3416.8" "2990.0" "" "" "" "" "" "" "" "" "" "" "2553.6" "2376.0" "3094.2" "2722.8" "2525.2" "3475.5" "2230.3" "2615.9" "3057.3" "1067.4" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397536938893978881" "False" "High" "IsMasterProtein" "O43491" "Band 4.1-like protein 2 OS=Homo sapiens OX=9606 GN=EPB41L2 PE=1 SV=1" "0.000" "False" "281.732" "46" "46" "126" "46" "1005" "112.5" "5.44" "464.60" "46" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2037" "ENSG00000079819" "EPB41L2" "B4DHI8; E9PPD9; hsa:2037; O43491; Q5T4F0; Q68DV2" "Splicing factor NOVA regulated synaptic proteins" "Neurexins and neuroligins" "2" "0" "0.984" "0.939" "0.981" "0.957" "0.939" "0.970" "0.981" "0.949" "0.827" "12513.5" "12315.0" "11754.2" "12272.5" "11981.0" "11750.5" "12138.8" "12271.6" "11873.7" "10343.3" "" "" "" "" "" "" "" "" "" "" "11250.9" "9964.9" "10632.1" "11979.7" "9886.9" "11750.5" "9089.2" "10839.1" "10624.5" "3692.3" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1205545228874989707" "False" "High" "IsMasterProtein" "Q92900" "Regulator of nonsense transcripts 1 OS=Homo sapiens OX=9606 GN=UPF1 PE=1 SV=2" "0.000" "False" "281.596" "53" "49" "110" "49" "1129" "124.3" "6.61" "429.19" "49" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09416, Pf13086, Pf13087, Pf18141" "5976" "ENSG00000005007" "UPF1" "hsa:5976; O00239; O43343; Q86Z25; Q92842; Q92900" "Pathophysiological roles of DUX4 in FSHD1" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "3" "0" "1.011" "0.989" "1.039" "1.008" "0.994" "1.006" "0.983" "1.013" "0.890" "9635.6" "9736.9" "9526.7" "10009.1" "9715.3" "9580.6" "9698.1" "9475.3" "9762.5" "8577.2" "" "" "" "" "" "" "" "" "" "" "8663.3" "7878.8" "8617.2" "9770.2" "8017.2" "9580.6" "7261.7" "8369.2" "8735.4" "3061.8" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6996937188134376608" "False" "High" "IsMasterProtein" "Q16531" "DNA damage-binding protein 1 OS=Homo sapiens OX=9606 GN=DDB1 PE=1 SV=1" "0.000" "False" "281.417" "46" "48" "123" "48" "1140" "126.9" "5.26" "484.64" "48" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "1642" "ENSG00000167986" "DDB1" "A6NG77; B2R648; B4DG00; hsa:1642; O15176; Q13289; Q16531; Q58F96" "Hippo-Merlin signaling dysregulation; Hepatitis B infection; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Neddylation; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER" "14" "0" "1.027" "1.098" "0.977" "1.025" "1.033" "0.990" "0.965" "1.088" "0.815" "13012.1" "13360.0" "14293.2" "12717.1" "13340.4" "13442.6" "12887.5" "12563.0" "14159.6" "10603.3" "" "" "" "" "" "" "" "" "" "" "11699.1" "10810.4" "12928.7" "12413.6" "11008.7" "13442.6" "9649.8" "11096.5" "12669.9" "3785.1" "49" "49" "49" "49" "49" "49" "49" "49" "49" "49" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "682895518506643546" "False" "High" "IsMasterProtein" "P11021" "Endoplasmic reticulum chaperone BiP OS=Homo sapiens OX=9606 GN=HSPA5 PE=1 SV=2" "0.000" "False" "278.376" "58" "39" "176" "36" "654" "72.3" "5.16" "713.28" "39" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "translation activity;other molecular function" "Pf00012" "3309" "ENSG00000044574" "HSPA5" "B0QZ61; hsa:3309; P11021; Q2EF78; Q9NPF1; Q9UK02" "Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Photodynamic therapy-induced unfolded protein response; Prion disease pathway; Unfolded protein response; Orexin receptor pathway" "Regulation of HSF1-mediated heat shock response; Platelet degranulation ; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; ATF6B (ATF6-beta) activates chaperones; IRE1alpha activates chaperones; PERK regulates gene expression; ATF6 (ATF6-alpha) activates chaperone genes" "14" "0" "1.020" "1.052" "1.042" "0.973" "1.128" "0.979" "1.054" "1.062" "0.799" "11851.8" "12087.8" "12463.8" "12347.6" "11533.1" "13374.7" "11607.8" "12495.2" "12592.0" "9473.3" "" "" "" "" "" "" "" "" "" "" "10655.9" "9781.0" "11273.9" "12053.0" "9517.3" "13374.7" "8691.6" "11036.6" "11267.2" "3381.7" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576515921520274560" "False" "High" "IsMasterProtein" "P13667" "Protein disulfide-isomerase A4 OS=Homo sapiens OX=9606 GN=PDIA4 PE=1 SV=2" "0.000" "False" "272.528" "62" "36" "125" "35" "645" "72.9" "5.07" "470.18" "36" "protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "9601" "ENSG00000155660" "PDIA4" "A8K4K6; hsa:9601; P13667; Q549T6" "" "" "0" "1" "0.943" "1.001" "0.991" "0.961" "0.944" "0.946" "0.965" "0.991" "1.021" "12125.2" "11429.8" "12134.4" "12012.9" "11648.3" "11446.2" "11466.9" "11694.8" "12018.0" "12374.2" "" "" "" "" "" "" "" "" "" "" "10901.7" "9248.6" "10975.9" "11726.3" "9612.4" "11446.2" "8586.2" "10329.6" "10753.6" "4417.3" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-516006275001987462" "False" "High" "IsMasterProtein" "Q14566" "DNA replication licensing factor MCM6 OS=Homo sapiens OX=9606 GN=MCM6 PE=1 SV=1" "0.000" "False" "270.665" "56" "48" "123" "48" "821" "92.8" "5.41" "447.69" "48" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855, Pf18263" "4175" "ENSG00000076003" "MCM6" "B2R6H2; hsa:4175; Q13504; Q14566; Q99859" "Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "11" "0" "1.015" "1.056" "0.999" "1.005" "0.987" "1.004" "1.000" "1.026" "0.920" "11259.0" "11433.4" "11885.8" "11243.7" "11310.4" "11116.1" "11303.8" "11260.1" "11551.3" "10359.9" "" "" "" "" "" "" "" "" "" "" "10123.0" "9251.5" "10751.1" "10975.4" "9333.5" "11116.1" "8464.0" "9945.6" "10336.0" "3698.2" "47" "47" "47" "47" "47" "47" "47" "47" "47" "47" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2890284807861643792" "False" "High" "IsMasterProtein" "P22102" "Trifunctional purine biosynthetic protein adenosine-3 OS=Homo sapiens OX=9606 GN=GART PE=1 SV=1" "0.000" "False" "269.668" "52" "46" "104" "46" "1010" "107.7" "6.70" "421.54" "46" "other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00551, Pf00586, Pf01071, Pf02769, Pf02843, Pf02844" "2618" "ENSG00000159131; ENSG00000262473" "GART" "A8K945; A8KA32; D3DSF3; D3DSF4; hsa:2618; O14659; P22102; Q52M77" "Folate metabolism; One-carbon metabolism; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "4" "0" "1.010" "0.989" "1.008" "0.982" "0.985" "1.007" "0.962" "1.023" "1.134" "9359.6" "9452.9" "9254.5" "9436.6" "9187.8" "9219.5" "9429.6" "9003.0" "9571.5" "10618.0" "" "" "" "" "" "" "" "" "" "" "8415.2" "7649.0" "8371.0" "9211.4" "7581.9" "9219.5" "7060.6" "7952.0" "8564.5" "3790.3" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293079878251606526" "False" "High" "IsMasterProtein" "P14625" "Endoplasmin OS=Homo sapiens OX=9606 GN=HSP90B1 PE=1 SV=1" "0.000" "False" "269.100" "49" "42" "166" "32" "803" "92.4" "4.84" "646.20" "42" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00183, Pf13589" "7184" "ENSG00000166598" "HSP90B1" "hsa:7184; P14625; Q96A97" "Photodynamic therapy-induced unfolded protein response; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Interleukin-4 and Interleukin-13 signaling; Trafficking and processing of endosomal TLR; Scavenging by Class A Receptors; ATF6 (ATF6-alpha) activates chaperone genes" "11" "6" "1.003" "1.038" "1.020" "1.012" "1.002" "0.993" "1.025" "1.067" "0.750" "16900.8" "16955.1" "17545.9" "17238.3" "17108.9" "16927.6" "16789.7" "17323.5" "18030.1" "12680.9" "" "" "" "" "" "" "" "" "" "" "15195.5" "13719.4" "15870.9" "16827.0" "14118.5" "16927.6" "12571.7" "15301.2" "16133.2" "4526.7" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5988193438521902409" "False" "High" "IsMasterProtein" "P26640" "Valine--tRNA ligase OS=Homo sapiens OX=9606 GN=VARS1 PE=1 SV=4" "0.000" "False" "268.742" "42" "46" "111" "46" "1264" "140.4" "7.59" "428.01" "46" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf00043, Pf00133, Pf08264" "7407" "ENSG00000096171; ENSG00000204394; ENSG00000224264; ENSG00000226589; ENSG00000231116" "VARS1" "B0V1N1; B4DZ61; hsa:7407; P26640; Q5JQ90; Q96E77; Q9UQM2" "Amino acid metabolism" "Cytosolic tRNA aminoacylation" "2" "0" "1.001" "1.002" "0.975" "0.987" "0.957" "1.012" "0.979" "0.963" "0.881" "8672.6" "8685.0" "8688.6" "8456.1" "8563.9" "8298.3" "8777.2" "8486.9" "8349.8" "7641.2" "" "" "" "" "" "" "" "" "" "" "7797.5" "7027.6" "7859.2" "8254.3" "7067.1" "8298.3" "6572.2" "7496.2" "7471.3" "2727.7" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6560846777174153588" "False" "High" "IsMasterProtein" "P53621" "Coatomer subunit alpha OS=Homo sapiens OX=9606 GN=COPA PE=1 SV=2" "0.000" "False" "268.006" "49" "55" "106" "55" "1224" "138.3" "7.66" "416.91" "55" "transport;signal transduction" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00400, Pf04053, Pf06957" "1314" "ENSG00000122218" "COPA" "hsa:1314; P53621; Q5T201; Q8IXZ9" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.007" "0.992" "0.988" "0.972" "0.978" "0.966" "0.970" "1.015" "0.804" "10350.8" "10421.4" "10270.3" "10224.6" "10058.3" "10128.2" "10001.2" "10042.5" "10502.7" "8326.3" "" "" "" "" "" "" "" "" "" "" "9306.4" "8432.6" "9289.8" "9980.6" "8300.3" "10128.2" "7488.6" "8870.2" "9397.7" "2972.3" "50" "50" "50" "50" "50" "50" "50" "50" "50" "50" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6674387397432112473" "False" "High" "IsMasterProtein" "P68371" "Tubulin beta-4B chain OS=Homo sapiens OX=9606 GN=TUBB4B PE=1 SV=1" "0.000" "False" "265.844" "66" "25" "283" "1" "445" "49.8" "4.89" "869.07" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00091, Pf03953" "10383" "ENSG00000188229" "TUBB4B" "A2BFA2; hsa:10383; P05217; P68371" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "MHC class II antigen presentation; COPI-mediated anterograde transport; PKR-mediated signaling; HCMV Early Events; Formation of tubulin folding intermediates by CCT/TriC; Prefoldin mediated transfer of substrate to CCT/TriC; Neutrophil degranulation; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Hedgehog 'off' state" "42" "33" "0.992" "0.969" "1.096" "0.977" "0.999" "1.070" "1.035" "0.991" "0.830" "17086.6" "16949.9" "16560.4" "18728.8" "16688.7" "17077.0" "18274.3" "17686.3" "16939.5" "14182.4" "" "" "" "" "" "" "" "" "" "" "15362.5" "13715.2" "14979.4" "18281.9" "13771.8" "17077.0" "13683.3" "15621.7" "15157.4" "5062.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8375301801822560127" "False" "High" "IsMasterProtein" "P36776" "Lon protease homolog, mitochondrial OS=Homo sapiens OX=9606 GN=LONP1 PE=1 SV=2" "0.000" "False" "265.437" "40" "32" "109" "32" "959" "106.4" "6.39" "431.35" "32" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00004, Pf02190, Pf05362" "9361" "ENSG00000196365" "LONP1" "B3KPH8; D6W635; E5KMH8; F5GZ27; hsa:9361; P36776; P36777; Q8N8K8; Q9UQ95" "" "Mitochondrial protein degradation" "1" "0" "1.011" "0.996" "1.012" "0.999" "0.977" "0.981" "1.020" "1.023" "0.787" "10656.0" "10769.5" "10612.7" "10786.1" "10646.4" "10409.4" "10449.7" "10871.2" "10897.6" "8383.5" "" "" "" "" "" "" "" "" "" "" "9580.8" "8714.3" "9599.5" "10528.8" "8785.6" "10409.4" "7824.5" "9602.2" "9751.1" "2992.7" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243510454319930112" "False" "High" "IsMasterProtein" "P33992" "DNA replication licensing factor MCM5 OS=Homo sapiens OX=9606 GN=MCM5 PE=1 SV=5" "0.000" "False" "265.405" "61" "42" "136" "42" "734" "82.2" "8.37" "484.64" "42" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4174" "ENSG00000100297" "MCM5" "hsa:4174; O60785; P33992; Q14578; Q9BTJ4; Q9BWL8" "Cell cycle; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "10" "0" "1.010" "1.041" "1.004" "1.006" "1.033" "0.991" "0.989" "1.030" "0.873" "10232.4" "10330.3" "10654.7" "10269.1" "10289.1" "10565.9" "10141.3" "10116.2" "10541.4" "8937.9" "" "" "" "" "" "" "" "" "" "" "9199.9" "8358.9" "9637.5" "10024.1" "8490.7" "10565.9" "7593.5" "8935.3" "9432.4" "3190.6" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5530158233237029042" "False" "High" "IsMasterProtein" "Q15075" "Early endosome antigen 1 OS=Homo sapiens OX=9606 GN=EEA1 PE=1 SV=2" "0.000" "False" "265.236" "45" "59" "98" "59" "1411" "162.4" "5.68" "390.81" "59" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "8411" "ENSG00000102189" "EEA1" "hsa:8411; Q14221; Q15075" "VEGFA-VEGFR2 signaling" "Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "0.931" "0.979" "0.983" "1.020" "0.964" "1.002" "1.038" "1.009" "0.841" "8985.4" "8369.6" "8800.1" "8830.0" "9161.8" "8662.9" "8999.3" "9326.0" "9066.6" "7555.6" "" "" "" "" "" "" "" "" "" "" "8078.7" "6772.4" "7960.0" "8619.3" "7560.5" "8662.9" "6738.5" "8237.3" "8112.7" "2697.1" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8321804652329171157" "False" "High" "IsMasterProtein" "Q9BXJ9" "N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA15 PE=1 SV=1" "0.000" "False" "263.915" "50" "48" "123" "39" "866" "101.2" "7.42" "433.30" "48" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf12569, Pf13181" "80155" "ENSG00000164134" "NAA15" "D3DNY6; Q52LG9; Q8IWH4; Q8NEV2; Q9BXJ9; Q9H8P6" "" "" "0" "11" "1.012" "1.005" "1.015" "0.993" "1.004" "0.989" "1.014" "0.998" "0.801" "13182.8" "13338.7" "13247.0" "13377.9" "13086.7" "13234.3" "13042.3" "13373.7" "13157.0" "10553.2" "" "" "" "" "" "" "" "" "" "" "11852.6" "10793.2" "11982.3" "13058.7" "10799.4" "13234.3" "9765.8" "11812.5" "11772.8" "3767.2" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "528371413836643526" "False" "High" "IsMasterProtein" "Q92945" "Far upstream element-binding protein 2 OS=Homo sapiens OX=9606 GN=KHSRP PE=1 SV=4" "0.000" "False" "261.647" "60" "38" "162" "34" "711" "73.1" "7.30" "636.43" "38" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf09005" "8570" "ENSG00000088247" "KHSRP" "hsa:8570; O00301; Q59EZ9; Q5U4P6; Q92945; Q9UNT5; Q9UQH5" "Pre-implantation embryo" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "3" "4" "0.995" "0.996" "1.028" "0.989" "1.035" "0.976" "1.065" "0.983" "0.825" "13873.0" "13804.4" "13817.0" "14255.9" "13718.6" "14360.3" "13542.8" "14772.7" "13642.6" "11450.3" "" "" "" "" "" "" "" "" "" "" "12473.2" "11170.0" "12497.9" "13915.7" "11320.8" "14360.3" "10140.5" "13048.2" "12207.3" "4087.4" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054273267636823051" "False" "High" "IsMasterProtein" "Q08211" "ATP-dependent RNA helicase A OS=Homo sapiens OX=9606 GN=DHX9 PE=1 SV=4" "0.000" "False" "260.631" "43" "42" "103" "42" "1270" "140.9" "6.84" "417.14" "42" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1660" "ENSG00000135829" "DHX9" "B2RNV4; hsa:1660; Q05CI5; Q08211; Q12803; Q32Q22; Q5VY62; Q6PD69; Q99556" "MECP2 and associated Rett syndrome; mRNA processing" "mRNA Splicing - Major Pathway; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "6" "0" "1.023" "1.047" "0.937" "1.022" "1.015" "0.979" "0.955" "1.034" "1.046" "8247.1" "8433.6" "8630.9" "7730.9" "8424.6" "8371.0" "8071.9" "7879.8" "8528.3" "8627.5" "" "" "" "" "" "" "" "" "" "" "7414.9" "6824.2" "7806.9" "7546.4" "6952.1" "8371.0" "6044.1" "6960.0" "7631.1" "3079.8" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-795610127174802190" "False" "High" "IsMasterProtein" "P15311" "Ezrin OS=Homo sapiens OX=9606 GN=EZR PE=1 SV=4" "0.000" "False" "260.133" "64" "46" "184" "32" "586" "69.4" "6.27" "609.69" "46" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "7430" "ENSG00000092820" "EZR" "E1P5A8; hsa:7430; P15311; P23714; Q4VX75; Q96CU8; Q9NSJ4" "Pathogenic Escherichia coli infection; AGE/RAGE pathway; VEGFA-VEGFR2 signaling; 16p11.2 proximal deletion syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; GDNF signaling" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Netrin-1 signaling" "11" "3" "1.002" "0.994" "1.022" "0.983" "0.979" "0.988" "1.048" "0.963" "0.851" "10529.3" "10552.2" "10471.0" "10763.1" "10354.3" "10312.7" "10399.7" "11038.1" "10138.8" "8965.5" "" "" "" "" "" "" "" "" "" "" "9466.9" "8538.5" "9471.3" "10506.3" "8544.6" "10312.7" "7787.0" "9749.6" "9072.1" "3200.4" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851021478040607723" "False" "High" "IsMasterProtein" "P31939" "Bifunctional purine biosynthesis protein ATIC OS=Homo sapiens OX=9606 GN=ATIC PE=1 SV=3" "0.000" "False" "259.874" "74" "34" "137" "34" "592" "64.6" "6.71" "575.20" "34" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf01808, Pf02142" "471" "ENSG00000138363" "ATIC" "A8K202; E9PBU3; hsa:471; P31939; Q13856; Q53S28" "One-carbon metabolism" "Signaling by ALK fusions and activated point mutants; Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.992" "0.991" "1.065" "1.003" "0.993" "1.009" "1.018" "1.033" "0.797" "10647.2" "10561.4" "10556.4" "11343.2" "10678.8" "10576.1" "10747.9" "10841.0" "10996.9" "8481.6" "" "" "" "" "" "" "" "" "" "" "9572.9" "8545.9" "9548.6" "11072.5" "8812.3" "10576.1" "8047.8" "9575.4" "9839.9" "3027.7" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469021931412063719" "False" "High" "IsMasterProtein" "P53618" "Coatomer subunit beta OS=Homo sapiens OX=9606 GN=COPB1 PE=1 SV=3" "0.000" "False" "259.720" "51" "40" "102" "40" "953" "107.1" "6.05" "400.27" "40" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf07718, Pf14806" "1315" "ENSG00000129083" "COPB1" "D3DQX0; hsa:1315; P53618; Q6GTT7; Q9NTK2; Q9UNW7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Neutrophil degranulation; COPI-mediated anterograde transport" "3" "0" "0.991" "0.982" "0.955" "0.984" "0.984" "0.980" "0.988" "1.010" "0.821" "8503.2" "8428.8" "8349.1" "8121.5" "8367.3" "8369.4" "8336.4" "8401.1" "8589.9" "6982.0" "" "" "" "" "" "" "" "" "" "" "7645.2" "6820.3" "7552.0" "7927.8" "6904.9" "8369.4" "6242.1" "7420.4" "7686.1" "2492.4" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7224600777690592247" "False" "High" "IsMasterProtein" "P50991" "T-complex protein 1 subunit delta OS=Homo sapiens OX=9606 GN=CCT4 PE=1 SV=4" "0.000" "False" "253.482" "72" "37" "173" "36" "539" "57.9" "7.83" "638.44" "37" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00118" "10575" "ENSG00000115484" "CCT4" "B2R6I3; B7Z8B1; F5H5W3; hsa:10575; O14870; P50991; Q53QP9; Q96C51" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; BBSome-mediated cargo-targeting to cilium; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "1.029" "1.015" "1.037" "1.003" "1.016" "1.031" "1.055" "1.020" "0.818" "10833.8" "11142.8" "10997.6" "11238.9" "10863.7" "11005.5" "11165.8" "11433.9" "11054.3" "8865.6" "" "" "" "" "" "" "" "" "" "" "9740.6" "9016.4" "9947.7" "10970.7" "8964.9" "11005.5" "8360.7" "10099.1" "9891.3" "3164.8" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1936662048644361405" "False" "High" "IsMasterProtein" "P55060" "Exportin-2 OS=Homo sapiens OX=9606 GN=CSE1L PE=1 SV=3" "0.000" "False" "252.663" "45" "41" "112" "41" "971" "110.3" "5.77" "407.11" "41" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf03378, Pf03810, Pf08506" "1434" "ENSG00000124207" "CSE1L" "A3RLL6; B2R5T4; E1P5Y0; F8W904; hsa:1434; O75432; P55060; Q32M40; Q9H5B7; Q9NTS0; Q9UP98; Q9UP99; Q9UPA0" "" "" "0" "0" "1.055" "1.029" "1.012" "1.046" "0.980" "1.033" "1.046" "0.999" "0.894" "10919.3" "11519.0" "11231.9" "11045.2" "11416.4" "10699.5" "11284.4" "11416.2" "10907.9" "9757.1" "" "" "" "" "" "" "" "" "" "" "9817.5" "9320.7" "10159.6" "10781.6" "9421.0" "10699.5" "8449.5" "10083.5" "9760.3" "3483.0" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1039523901046503215" "False" "High" "IsMasterProtein" "P42704" "Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens OX=9606 GN=LRPPRC PE=1 SV=3" "0.000" "False" "251.839" "43" "54" "89" "54" "1394" "157.8" "6.13" "335.66" "54" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01535" "10128" "ENSG00000138095" "LRPPRC" "A0PJE3; A8K1V1; hsa:10128; P42704; Q53PC0; Q53QN7; Q6ZUD8; Q7Z7A6; Q96D84" "Ciliary landscape" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial RNA degradation" "5" "0" "1.082" "0.964" "0.964" "1.069" "0.942" "0.997" "1.047" "0.964" "3.531" "8191.8" "8865.5" "7897.6" "7896.9" "8757.1" "7719.0" "8166.7" "8575.4" "7893.6" "28928.0" "" "" "" "" "" "" "" "" "" "" "7365.2" "7173.6" "7143.6" "7708.5" "7226.6" "7719.0" "6115.0" "7574.4" "7063.1" "10326.5" "48" "48" "48" "48" "48" "48" "48" "48" "48" "48" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459324364456559330" "False" "High" "IsMasterProtein" "Q04637" "Eukaryotic translation initiation factor 4 gamma 1 OS=Homo sapiens OX=9606 GN=EIF4G1 PE=1 SV=4" "0.000" "False" "251.756" "31" "49" "116" "42" "1599" "175.4" "5.33" "393.43" "49" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02020, Pf02847, Pf02854" "1981" "ENSG00000114867" "EIF4G1" "D3DNT2; D3DNT4; D3DNT5; E9PFM1; G5E9S1; hsa:1981; O43177; O95066; Q04637; Q5HYG0; Q6ZN21; Q8N102" "Translation factors; VEGFA-VEGFR2 signaling; Acute viral myocarditis; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Pleural mesothelioma" "AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "20" "9" "1.043" "1.003" "1.043" "1.039" "1.001" "1.054" "1.071" "0.975" "1.703" "8758.2" "9133.9" "8781.6" "9136.8" "9097.9" "8764.1" "9231.1" "9380.9" "8536.8" "14918.3" "" "" "" "" "" "" "" "" "" "" "7874.5" "7390.9" "7943.2" "8918.8" "7507.8" "8764.1" "6912.0" "8285.8" "7638.7" "5325.4" "46" "46" "46" "46" "46" "46" "46" "46" "46" "46" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-45443448741042807" "False" "High" "IsMasterProtein" "P24928" "DNA-directed RNA polymerase II subunit RPB1 OS=Homo sapiens OX=9606 GN=POLR2A PE=1 SV=2" "0.000" "False" "248.837" "34" "61" "100" "61" "1970" "217.0" "7.37" "342.09" "61" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04990, Pf04992, Pf04997, Pf04998, Pf05000, Pf05001" "5430" "" "POLR2A" "A6NN93; B9EH88; hsa:5430; P24928; Q6NX41" "Pyrimidine metabolism; Eukaryotic transcription initiation; mRNA processing" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "44" "0" "0.998" "0.890" "0.955" "0.980" "0.898" "0.949" "0.984" "0.919" "0.901" "9139.6" "9119.2" "8130.2" "8727.0" "8960.0" "8206.0" "8670.0" "8997.0" "8403.2" "8238.7" "" "" "" "" "" "" "" "" "" "" "8217.4" "7379.0" "7354.0" "8518.8" "7394.0" "8206.0" "6491.9" "7946.7" "7519.1" "2941.0" "55" "55" "55" "55" "55" "55" "55" "55" "55" "55" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6102726942936219024" "False" "High" "IsMasterProtein" "Q14152" "Eukaryotic translation initiation factor 3 subunit A OS=Homo sapiens OX=9606 GN=EIF3A PE=1 SV=1" "0.000" "False" "248.251" "40" "62" "108" "62" "1382" "166.5" "6.79" "376.82" "62" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399" "8661" "ENSG00000107581" "EIF3A" "B1AMV5; B4DYS1; F5H335; hsa:8661; O00653; Q14152; Q15778" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; NF1 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.038" "1.001" "0.948" "0.976" "1.049" "1.008" "0.989" "0.995" "1.540" "8076.0" "8385.0" "8083.0" "7655.9" "7881.5" "8471.7" "8143.7" "7984.6" "8034.7" "12440.9" "" "" "" "" "" "" "" "" "" "" "7261.1" "6784.8" "7311.3" "7473.2" "6504.0" "8471.7" "6097.8" "7052.5" "7189.4" "4441.0" "52" "52" "52" "52" "52" "52" "52" "52" "52" "52" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6480137070562712140" "False" "High" "IsMasterProtein" "Cont_Q2KJD0" "Tubulin beta-5 chain OS=Bos taurus OX=9913 GN=TUBB5 PE=2 SV=1" "0.000" "True" "246.569" "60" "23" "291" "3" "444" "49.6" "4.89" "870.02" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100022562; 100172938; 100303606; 100598146; 100689091; 100718713; 100918219; 100998701; 101034943; 101095657; 101129890; 101318992; 101341456; 101365832; 101593768; 101827904; 101925816; 101965993; 102168953; 102382532; 102506772; 102536943; 102568349; 102831964; 102882060; 102926495; 102963307; 103014346; 103053177; 103080542; 103205965; 103221819; 103261319; 103665004; 104666199; 105074100; 105087494; 105308138; 105498618; 105513957; 105553127; 105600022; 105704569; 105817283; 105855398; 105996956; 106553108; 106825507; 106966617; 107160457; 107498082; 108520633; 108522550; 109249509; 109693530; 203068; 22154; 29214; 396254; 471960; 474830; 574113; 615087; 733686" "ENSACCG00020016918; ENSAMEG00000014418; ENSANAG00000034194; ENSANIG00000003763; ENSAOWG00000004252; ENSBGRG00000008599; ENSBIXG00000008022; ENSBIXG00005015569; ENSBMSG00010013877; ENSBTAG00000006969; ENSCABG00000008181; ENSCAFG00000000443; ENSCAFG00040015599; ENSCAFG00845007927; ENSCANG00000012112; ENSCATG00000014335; ENSCCNG00000028823; ENSCGRG00000007995; ENSCGRG00001023930; ENSCGRG00015028239; ENSCHIG00000025610; ENSCJAG00000048479; ENSCMUG00000016892; ENSCPOG00000035463; ENSCRFG00000007002; ENSCSAG00000008279; ENSCWAG00000006690; ENSEASG00005019680; ENSFCAG00000027444; ENSG00000183311; ENSG00000196230; ENSG00000224156; ENSG00000227739; ENSG00000229684; ENSG00000232421; ENSG00000232575; ENSG00000235067; ENSGAGG00000007027; ENSGGOG00000022655; ENSJJAG00000024145; ENSLCNG00005007041; ENSMFAG00000044340; ENSMICG00000010647; ENSMLEG00000037482; ENSMMMG00000020216; ENSMMNG00015000200; ENSMMNG00015000533; ENSMMNG00015004763; ENSMMSG00000005300; ENSMMUG00000030028; ENSMNEG00000044824; ENSMODG00000023805; ENSMSIG00000015128; ENSMUSG00000001525; ENSNLEG00000005348; ENSOANG00000004061; ENSOARG00000011626; ENSPANG00000015954; ENSPCLG00000013695; ENSPCOG00000022809; ENSPCTG00005009625; ENSPEMG00000025556; ENSPLOG00000016488; ENSPPYG00000016419; ENSPSNG00000012487; ENSPTEG00000030284; ENSPTIG00000006316; ENSPTRG00000017675; ENSRBIG00000034281; ENSRFEG00010000368; ENSRNOG00000061216; ENSRNOG00055006845; ENSRNOG00060003580; ENSRNOG00065029671; ENSRROG00000035442; ENSSBOG00000020987; ENSSDAG00000016166; ENSSHAG00000028751; ENSSHBG00005000940; ENSSOCG00000016453; ENSSSCG00000001379; ENSSSCG00015022877; ENSSSCG00025077784; ENSSSCG00030060370; ENSSSCG00035060189; ENSSSCG00040067819; ENSSSCG00050020383; ENSSSCG00055030461; ENSSSCG00060047808; ENSSSCG00065051381; ENSSSCG00070024618; ENSSSUG00005002289; ENSSTOG00000023492; ENSSVLG00005006345; ENSTGEG00000009306; ENSTGEG00000012139; ENSTGUG00000029087; ENSTSYG00000035292; ENSUAMG00000026276; ENSUMAG00000019678; ENSUPAG00010003937; ENSVURG00010001582; ENSVVUG00000009892; ENSZLMG00000006871" "LOC101341456; LOC106553108; LOC111152509; LOC112622444; LOC114901775; LOC115493080; LOC116436919; TBB7; Tubb; TUBB; Tubb5; TUBB5" "A0A0B8RPP1; A0A0D9R7E7; A0A151MZH9; A0A1S3GEI3; A0A1U7R7I2; A0A1U7SI21; A0A1U7TVN8; A0A1V4L0F2; A0A1W7RC49; A0A218U794; A0A286XDY8; A0A2D4LT52; A0A2D4PSK3; A0A2I3MS98; A0A2J8NXA1; A0A2J8SJF9; A0A2K5EIS8; A0A2K5HGL3; A0A2K5KT86; A0A2K5WBU4; A0A2K5ZFW6; A0A2K6E8N3; A0A2K6G5S3; A0A2K6LAT7; A0A2K6Q336; A0A2K6SLG3; A0A2U3V2D1; A0A2U3WJT7; A0A2Y9EAZ4; A0A2Y9EP82; A0A2Y9HLQ0; A0A2Y9K0M9; A0A2Y9MS78; A0A340WI11; A0A341AY80; A0A384BFD0; A0A384C9R0; A0A387L8L1; A0A3Q7RLV2; A0A3Q7S184; A0A452G3S8; A0A452H2Z1; A0A452SPC5; A0A480TK33; A0A485NK51; A0A4D9DG40; A0A4W2C297; A0A4X2JR93; A0A5E4AVV9; A0A5N3VZ42; A0A5N3WG73; A0A5N4CSN6; A0A663FK44; A0A667GBL5; A0A669QEL9; A0A671DQJ6; A0A672TGM1; A0A673T1T3; A0A674HV74; A0A6B2F8Z8; A0A6B2F9Q6; A0A6I9ILN3; A0A6I9MI92; A0A6I9YS87; A0A6I9ZH14; A0A6J0V952; A0A6J0X5U3; A0A6J1VI28; A0A6J2LA47; A0A6J3H9X1; A0A6P3EF00; A0A6P3RZ49; A0A6P5RBI7; A0A6P6HAZ1; A0A6P7XJA2; A0A6P8P8N4; A0A6P9CC67; A0A6P9FE20; A0A7J7R527; A0A7J7RLA9; A0A7J8GU45; A0A7J8KJ46; A0A7N4PPV2; A0A811YN81; A0A8B7ATI1; A0A8B7EBT6; A0A8B7VFP4; A0A8B9M868; A0A8B9P6J0; A0A8B9X0N8; A0A8C0I1Y2; A0A8C0IPC0; A0A8C0SSP9; A0A8C3VZK5; A0A8C3XAR0; A0A8C4PT60; A0A8C5LKQ9; A0A8C6AUQ3; A0A8C6EXU6; A0A8C6FHM7; A0A8C6MWA3; A0A8C8XQA1; A0A8C9BZ32; A0A8C9I594; A0A8C9J767; A0A8C9USK8; A0A8D0FX24; A0A8D2B3E9; A0A8D2EVN1; A0A8D2GXX0; A0A8D2P6S2; A0A8I3N9K0; A0A8K1G105; A0A8U0NH48; A0A8U7NRV1; A0A9B0X0S4; A0A9F2WGG8; A0A9V1E7C8; A0A9W3GX28; A0A9X9LVU0; A0AA35K0A2; A5D9A3; A6KT85; aju:106966617; amj:102568349; asn:102382532; B1B178; bacu:103014346; bta:615087; caty:105600022; ccan:109693530; cdk:105087494; cfa:474830; cfr:102506772; cge:100689091; chx:102168953; cpoc:100718713; csab:103221819; csyr:103261319; dle:111170669; dord:105996956; F6TYN8; F7F082; fca:101095657; G1LKN6; G1R063; G3HQP8; G3SB76; gga:396254; ggo:101129890; gsh:117346094; hsa:203068; I3ND93; J3S5D8; L5KK71; M3X7Z9; maua:101827904; mcal:110312171; mcc:574113; mdo:100022562; mmu:22154; mmur:105855398; mni:105498618; mpuf:101674529; muo:115466267; nasi:112395403; nle:100598146; nss:113423183; nsu:110586671; oas:100303606; oro:101365832; P05218; P07437; P09244; P69893; P69895; P69897; P99024; pale:102882060; panu:100998701; pbi:103053177; pcad:102979859; pcoq:105817283; pdic:114493854; pgut:117667950; pon:100172938; ptg:102963307; ptr:471960; pvp:105308138; pvt:110090161; Q1XHT6; Q2KJD0; Q3TFB6; Q3THH9; Q3TIL1; Q3UAV4; Q3UF52; Q5R943; Q5SU16; Q5TM69; Q6P9X8; Q767L7; Q7JJU6; Q8WUC1; Q9CY33; ray:107498082; rbb:108520633; rbb:108522550; rno:29214; rro:104666199; S9WJD1; sbq:101034943; shr:100918219; ssc:733686; T1DHR5; tmu:101341456; tsr:106553108; U3FAQ9; U3FM57; umr:103665004; vpc:102536943; vvp:112913571; W5PPT6; zca:113927996" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Opioid receptor pathways; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Potential therapeutics for SARS; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Neutrophil degranulation; Regulation of PLK1 Activity at G2/M Transition; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Neutrophil degranulation; Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "57" "0" "0.940" "0.945" "1.149" "0.941" "0.924" "1.027" "0.997" "0.964" "0.800" "2787.1" "2619.2" "2634.3" "3201.9" "2622.9" "2574.0" "2861.7" "2779.8" "2687.0" "2230.8" "" "" "" "" "" "" "" "" "" "" "2505.9" "2119.3" "2382.8" "3125.5" "2164.5" "2574.0" "2142.8" "2455.3" "2404.3" "796.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8579706144891720478" "False" "High" "IsMasterProtein" "O00267" "Transcription elongation factor SPT5 OS=Homo sapiens OX=9606 GN=SUPT5H PE=1 SV=1" "0.000" "False" "244.906" "48" "41" "80" "41" "1087" "120.9" "5.06" "326.45" "41" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf03439, Pf11942" "6829" "ENSG00000196235" "SUPT5H" "hsa:6829; O00267; O43279; Q59G52; Q99639" "Initiation of transcription and translation elongation at the HIV-1 LTR; mRNA processing" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "20" "0" "1.004" "1.067" "1.007" "1.012" "1.057" "0.994" "1.003" "1.072" "0.949" "5891.4" "5916.5" "6285.1" "5932.4" "5959.7" "6225.0" "5857.7" "5908.8" "6314.5" "5590.9" "" "" "" "" "" "" "" "" "" "" "5297.0" "4787.4" "5685.1" "5790.9" "4918.1" "6225.0" "4386.1" "5219.1" "5650.2" "1995.8" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3930283768056647308" "False" "High" "IsMasterProtein" "P31948" "Stress-induced-phosphoprotein 1 OS=Homo sapiens OX=9606 GN=STIP1 PE=1 SV=1" "0.000" "False" "244.895" "59" "36" "178" "36" "543" "62.6" "6.80" "578.62" "36" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf17830" "10963" "ENSG00000168439" "STIP1" "B4DM70; F5H0T1; G3XAD8; hsa:10963; P31948; Q3ZCU9; Q5TZU9" "VEGFA-VEGFR2 signaling" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RND1 GTPase cycle" "3" "0" "0.891" "0.943" "0.936" "0.952" "0.939" "0.942" "0.995" "0.953" "0.802" "19691.0" "17553.1" "18564.2" "18434.4" "18740.5" "18497.7" "18543.1" "19596.1" "18769.3" "15792.4" "" "" "" "" "" "" "" "" "" "" "17704.1" "14203.4" "16791.9" "17994.5" "15465.0" "18497.7" "13884.6" "17308.5" "16794.6" "5637.4" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649453304125061400" "False" "High" "IsMasterProtein" "Q12906" "Interleukin enhancer-binding factor 3 OS=Homo sapiens OX=9606 GN=ILF3 PE=1 SV=3" "0.000" "False" "244.081" "48" "37" "142" "31" "894" "95.3" "8.76" "510.78" "37" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf07528, Pf20965" "3609" "ENSG00000129351" "ILF3" "A8K6F2; G5E9M5; hsa:3609; O43409; Q12906; Q6P1X1; Q86XY7; Q99544; Q99545; Q9BZH4; Q9BZH5; Q9NQ95; Q9NQ96; Q9NQ97; Q9NQ98; Q9NQ99; Q9NQA0; Q9NQA1; Q9NQA2; Q9NRN2; Q9NRN3; Q9NRN4; Q9UMZ9; Q9UN00; Q9UN84; Q9UNA2" "" "PKR-mediated signaling; Regulation of CDH11 gene transcription" "2" "8" "0.993" "0.969" "0.952" "0.965" "0.987" "0.970" "0.976" "0.948" "0.825" "13212.1" "13115.1" "12805.9" "12573.3" "12745.6" "13037.3" "12819.9" "12894.0" "12521.0" "10900.9" "" "" "" "" "" "" "" "" "" "" "11879.0" "10612.3" "11583.4" "12273.3" "10517.9" "13037.3" "9599.3" "11388.9" "11203.7" "3891.3" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "32097797701443302" "False" "High" "IsMasterProtein" "Q14008" "Cytoskeleton-associated protein 5 OS=Homo sapiens OX=9606 GN=CKAP5 PE=1 SV=3" "0.000" "False" "243.962" "30" "56" "78" "56" "2032" "225.4" "7.80" "287.82" "56" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21041" "9793" "ENSG00000175216" "CKAP5" "hsa:9793; Q05D70; Q0VAX7; Q0VAX8; Q14008; Q14668; Q2TA89; Q6NSH4" "4p16.3 copy number variation" "Separation of Sister Chromatids; Regulation of PLK1 Activity at G2/M Transition; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "14" "0" "0.970" "1.007" "0.999" "0.933" "0.956" "1.050" "0.900" "0.932" "2.119" "7918.0" "7679.8" "7974.1" "7910.5" "7385.1" "7567.6" "8314.9" "7125.3" "7382.1" "16774.6" "" "" "" "" "" "" "" "" "" "" "7119.1" "6214.2" "7212.8" "7721.7" "6094.4" "7567.6" "6226.0" "6293.5" "6605.5" "5988.0" "45" "45" "45" "45" "45" "45" "45" "45" "45" "45" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1511702505276588775" "False" "High" "IsMasterProtein" "Q12931" "Heat shock protein 75 kDa, mitochondrial OS=Homo sapiens OX=9606 GN=TRAP1 PE=1 SV=3" "0.000" "False" "243.579" "62" "36" "144" "35" "704" "80.1" "8.21" "536.08" "36" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00183" "10131" "ENSG00000126602" "TRAP1" "B4DR68; D3DUC8; F5H897; hsa:10131; O43642; O75235; Q12931; Q9UHL5" "TNF-alpha signaling pathway; TGF-beta signaling pathway; Clock-controlled autophagy in bone metabolism" "Respiratory electron transport" "4" "0" "1.013" "1.001" "1.009" "1.005" "0.979" "0.998" "0.998" "1.028" "0.789" "9163.1" "9281.6" "9172.2" "9241.3" "9210.8" "8971.1" "9141.4" "9148.2" "9421.8" "7229.4" "" "" "" "" "" "" "" "" "" "" "8238.5" "7510.3" "8296.6" "9020.8" "7600.9" "8971.1" "6844.9" "8080.3" "8430.5" "2580.7" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985965989456980911" "False" "High" "IsMasterProtein" "Q8TEQ6" "Gem-associated protein 5 OS=Homo sapiens OX=9606 GN=GEMIN5 PE=1 SV=3" "0.000" "False" "243.244" "35" "44" "78" "44" "1508" "168.5" "6.62" "315.72" "44" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00400, Pf12894, Pf21720" "25929" "ENSG00000082516" "GEMIN5" "Q14CV0; Q8TEQ6; Q8WWV4; Q969W4; Q9H9K3; Q9UFI5" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.020" "0.978" "0.967" "1.010" "0.936" "0.971" "0.961" "1.001" "0.817" "8685.4" "8861.4" "8493.3" "8395.4" "8771.5" "8125.9" "8436.3" "8344.1" "8694.9" "7093.5" "" "" "" "" "" "" "" "" "" "" "7809.1" "7170.3" "7682.5" "8195.0" "7238.4" "8125.9" "6316.9" "7370.0" "7780.1" "2532.2" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2050551167936510610" "False" "High" "IsMasterProtein" "Q01813" "ATP-dependent 6-phosphofructokinase, platelet type OS=Homo sapiens OX=9606 GN=PFKP PE=1 SV=2" "0.000" "False" "242.248" "49" "31" "96" "26" "784" "85.5" "7.55" "371.25" "31" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5214" "ENSG00000067057" "PFKP" "B3KS15; hsa:5214; Q01813; Q5VSR7; Q5VSR8" "Cori cycle; Clear cell renal cell carcinoma pathways; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "4" "1.008" "0.971" "0.984" "0.999" "0.892" "0.975" "0.978" "1.010" "0.792" "7999.2" "8061.6" "7768.2" "7871.7" "7993.3" "7132.0" "7802.9" "7820.7" "8075.9" "6337.2" "" "" "" "" "" "" "" "" "" "" "7192.0" "6523.2" "7026.6" "7683.9" "6596.3" "7132.0" "5842.6" "6907.7" "7226.2" "2262.2" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7382790352375516909" "False" "High" "IsMasterProtein" "Q15393" "Splicing factor 3B subunit 3 OS=Homo sapiens OX=9606 GN=SF3B3 PE=1 SV=4" "0.000" "False" "242.221" "42" "43" "88" "43" "1217" "135.5" "5.26" "335.38" "43" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "23450" "ENSG00000189091" "SF3B3" "hsa:23450; Q15393; Q6NTI8; Q96GC0; Q9BPY2; Q9UFX7; Q9UJ29" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.060" "0.995" "0.971" "1.056" "0.995" "0.993" "0.995" "1.025" "0.820" "7375.2" "7817.5" "7336.0" "7161.9" "7785.3" "7335.6" "7319.9" "7335.1" "7558.2" "6049.2" "" "" "" "" "" "" "" "" "" "" "6631.0" "6325.6" "6635.7" "6991.0" "6424.5" "7335.6" "5481.0" "6478.9" "6763.0" "2159.4" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6718063858029524947" "False" "High" "IsMasterProtein" "P50395" "Rab GDP dissociation inhibitor beta OS=Homo sapiens OX=9606 GN=GDI2 PE=1 SV=2" "0.000" "False" "241.309" "73" "32" "165" "23" "445" "50.6" "6.47" "609.27" "32" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2665" "ENSG00000057608" "GDI2" "hsa:2665; O43928; P50395; Q5SX88; Q9UQM6" "" "RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation" "2" "10" "1.002" "1.023" "1.023" "0.949" "0.985" "0.947" "0.993" "1.001" "0.745" "18141.3" "18180.6" "18556.6" "18557.5" "17210.2" "17865.2" "17181.7" "18016.3" "18160.5" "13512.3" "" "" "" "" "" "" "" "" "" "" "16310.8" "14711.1" "16785.0" "18114.7" "14202.2" "17865.2" "12865.3" "15913.2" "16249.9" "4823.5" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4943408873611006946" "False" "High" "IsMasterProtein" "Q02790" "Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens OX=9606 GN=FKBP4 PE=1 SV=3" "0.000" "False" "240.826" "72" "35" "182" "35" "459" "51.8" "5.43" "616.37" "35" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00254, Pf00515" "2288" "ENSG00000004478" "FKBP4" "D3DUQ1; hsa:2288; Q02790; Q9UCP1; Q9UCV7" "Androgen receptor signaling pathway" "Potential therapeutics for SARS; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Estrogen-dependent gene expression; Attenuation phase" "6" "0" "1.029" "1.018" "1.059" "0.996" "1.018" "1.023" "1.002" "1.021" "0.971" "14307.9" "14725.5" "14565.1" "15146.0" "14254.6" "14560.3" "14643.2" "14342.1" "14609.3" "13894.6" "" "" "" "" "" "" "" "" "" "" "12864.2" "11915.3" "13174.6" "14784.6" "11763.1" "14560.3" "10964.5" "12667.8" "13072.3" "4960.0" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8785242188080332383" "False" "High" "IsMasterProtein" "P28838" "Cytosol aminopeptidase OS=Homo sapiens OX=9606 GN=LAP3 PE=1 SV=3" "0.000" "False" "238.873" "64" "30" "119" "30" "519" "56.1" "7.93" "457.48" "30" "protein metabolism" "other cell component" "other molecular function" "Pf00883, Pf02789" "51056" "ENSG00000002549" "LAP3" "B3KMQ3; hsa:51056; P28838; Q6IAM6; Q6P0L6; Q9UQE3" "" "" "0" "0" "1.021" "1.010" "1.041" "1.049" "1.004" "1.034" "1.043" "1.072" "0.882" "12981.7" "13255.7" "13114.1" "13508.2" "13617.6" "13032.6" "13426.2" "13541.6" "13914.5" "11443.4" "" "" "" "" "" "" "" "" "" "" "11671.8" "10726.1" "11862.2" "13185.9" "11237.5" "13032.6" "10053.2" "11960.8" "12450.6" "4085.0" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4595887854081889880" "False" "High" "IsMasterProtein" "Q99460" "26S proteasome non-ATPase regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PSMD1 PE=1 SV=2" "0.000" "False" "237.705" "44" "38" "112" "38" "953" "105.8" "5.39" "397.89" "38" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf01851, Pf13646, Pf18004, Pf21505" "5707" "ENSG00000173692" "PSMD1" "B8ZZH9; hsa:5707; Q24JU0; Q53TI2; Q6GMU5; Q6P2P4; Q6PJM7; Q6PKG9; Q86VU1; Q8IV79; Q99460" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.996" "1.002" "0.982" "0.969" "0.949" "0.966" "0.968" "0.997" "0.843" "9542.9" "9506.6" "9563.9" "9368.8" "9251.1" "9059.1" "9215.5" "9241.6" "9515.1" "8046.0" "" "" "" "" "" "" "" "" "" "" "8580.0" "7692.4" "8650.8" "9145.2" "7634.2" "9059.1" "6900.3" "8162.8" "8514.0" "2872.2" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707926075363841764" "False" "High" "IsMasterProtein" "Q99798" "Aconitate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ACO2 PE=1 SV=2" "0.000" "False" "235.361" "51" "36" "120" "36" "780" "85.4" "7.61" "470.11" "36" "other metabolic processes;stress response;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00330, Pf00694" "50" "ENSG00000100412" "ACO2" "hsa:50; O75809; Q5JZ41; Q6FHX0; Q8TAQ6; Q99798" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "0.981" "0.946" "1.034" "0.967" "0.911" "0.970" "0.970" "0.918" "0.816" "12264.7" "12028.7" "11608.2" "12684.8" "11854.5" "11167.7" "11902.7" "11893.6" "11256.1" "10005.9" "" "" "" "" "" "" "" "" "" "" "11027.2" "9733.2" "10500.0" "12382.1" "9782.6" "11167.7" "8912.5" "10505.2" "10071.8" "3571.8" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250102899765152791" "False" "High" "IsMasterProtein" "Q9BVA1" "Tubulin beta-2B chain OS=Homo sapiens OX=9606 GN=TUBB2B PE=1 SV=1" "0.000" "False" "235.193" "58" "23" "253" "1" "445" "49.9" "4.89" "750.11" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "347733" "ENSG00000137285" "TUBB2B" "A8K068; hsa:347733; Q9BVA1" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "MHC class II antigen presentation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recycling pathway of L1; Recruitment of NuMA to mitotic centrosomes; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Assembly and cell surface presentation of NMDA receptors; PKR-mediated signaling; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "35" "0" "0.658" "0.838" "0.733" "0.546" "0.583" "0.512" "0.661" "0.551" "0.557" "178.8" "117.6" "149.8" "131.0" "97.7" "104.2" "91.6" "118.2" "98.5" "99.6" "" "" "" "" "" "" "" "" "" "" "160.8" "95.1" "135.5" "127.9" "80.6" "104.2" "68.6" "104.4" "88.1" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7048585715635486560" "False" "High" "IsMasterProtein" "Q13885" "Tubulin beta-2A chain OS=Homo sapiens OX=9606 GN=TUBB2A PE=1 SV=1" "0.000" "False" "234.907" "58" "23" "252" "1" "445" "49.9" "4.89" "751.18" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7280" "ENSG00000137267" "TUBB2A" "hsa:7280; Q13885; Q6FGZ8; Q8IWR2" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; The role of GTSE1 in G2/M progression after G2 checkpoint; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Translocation of SLC2A4 (GLUT4) to the plasma membrane; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "35" "3" "0.935" "1.060" "1.100" "0.934" "1.181" "1.039" "1.016" "1.122" "0.844" "520.4" "486.8" "551.7" "572.4" "486.0" "614.6" "540.8" "528.9" "583.9" "439.1" "" "" "" "" "" "" "" "" "" "" "467.9" "393.9" "499.1" "558.8" "401.0" "614.6" "405.0" "467.2" "522.5" "156.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6496925005546959600" "False" "High" "IsMasterProtein" "Q13509" "Tubulin beta-3 chain OS=Homo sapiens OX=9606 GN=TUBB3 PE=1 SV=2" "0.000" "False" "234.362" "60" "24" "265" "8" "450" "50.4" "4.93" "796.28" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10381" "ENSG00000258947" "TUBB3" "A8K854; hsa:10381; Q13509; Q9BTZ0; Q9BW10" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Exercise-induced circadian regulation; Alzheimer's disease; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Hedgehog 'off' state; Post-chaperonin tubulin folding pathway; PKR-mediated signaling; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Prefoldin mediated transfer of substrate to CCT/TriC" "38" "6" "0.997" "0.990" "0.989" "0.988" "0.963" "1.004" "1.015" "0.966" "0.770" "6729.6" "6711.3" "6659.0" "6656.7" "6650.0" "6483.0" "6754.0" "6830.2" "6501.7" "5183.2" "" "" "" "" "" "" "" "" "" "" "6050.6" "5430.5" "6023.3" "6497.9" "5487.7" "6483.0" "5057.2" "6032.8" "5817.7" "1850.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2158743068394578481" "False" "High" "IsMasterProtein" "P29401" "Transketolase OS=Homo sapiens OX=9606 GN=TKT PE=1 SV=3" "0.000" "False" "234.120" "56" "35" "124" "35" "623" "67.8" "7.66" "513.03" "35" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00456, Pf02779, Pf02780" "7086" "ENSG00000163931" "TKT" "A8K089; B4DE31; E7EPA7; hsa:7086; P29401; Q8TBA3; Q96HH3" "Pentose phosphate metabolism; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate" "7" "0" "1.015" "0.996" "1.122" "1.002" "0.972" "0.999" "0.982" "0.998" "0.808" "11866.8" "12042.4" "11818.1" "13315.2" "11888.1" "11530.5" "11849.8" "11651.3" "11837.4" "9585.4" "" "" "" "" "" "" "" "" "" "" "10669.4" "9744.3" "10689.9" "12997.5" "9810.3" "11530.5" "8872.8" "10291.2" "10592.0" "3421.7" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9169618704545618170" "False" "High" "IsMasterProtein" "P04075" "Fructose-bisphosphate aldolase A OS=Homo sapiens OX=9606 GN=ALDOA PE=1 SV=2" "0.000" "False" "234.032" "88" "33" "209" "26" "364" "39.4" "8.09" "877.82" "33" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "226" "ENSG00000149925" "ALDOA" "B4DXI7; hsa:226; P04075; Q6FH76; Q6FI10; Q96B15; Q9BWD9; Q9UCN2" "VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; 16p11.2 proximal deletion syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Neutrophil degranulation; Glycolysis; Gluconeogenesis; Platelet degranulation" "11" "7" "1.046" "1.042" "1.093" "0.999" "1.078" "0.996" "1.057" "1.029" "0.809" "15562.3" "16272.0" "16220.5" "17015.8" "15553.1" "16782.0" "15495.6" "16445.4" "16010.1" "12587.3" "" "" "" "" "" "" "" "" "" "" "13992.1" "13166.7" "14672.0" "16609.8" "12834.7" "16782.0" "11602.7" "14525.7" "14325.7" "4493.3" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-806880739347862445" "False" "High" "IsMasterProtein" "Q71U36" "Tubulin alpha-1A chain OS=Homo sapiens OX=9606 GN=TUBA1A PE=1 SV=1" "0.000" "False" "233.257" "63" "24" "283" "2" "451" "50.1" "5.06" "1065.30" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7846" "ENSG00000167552" "TUBA1A" "A8K0B8; G3V1U9; hsa:7846; P04687; P05209; Q71U36" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Recycling pathway of L1; Aggrephagy; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "42" "28" "0.977" "0.970" "1.069" "0.975" "0.964" "1.056" "1.004" "0.979" "0.847" "18745.9" "18309.2" "18185.0" "20041.3" "18285.2" "18070.4" "19795.2" "18828.5" "18357.7" "15886.4" "" "" "" "" "" "" "" "" "" "" "16854.4" "14815.1" "16449.0" "19563.1" "15089.3" "18070.4" "14822.2" "16630.6" "16426.3" "5671.0" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-291186294764485320" "False" "High" "IsMasterProtein" "P33993" "DNA replication licensing factor MCM7 OS=Homo sapiens OX=9606 GN=MCM7 PE=1 SV=4" "0.000" "False" "232.561" "61" "40" "112" "40" "719" "81.3" "6.46" "435.02" "40" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf14551, Pf17207, Pf17855" "4176" "ENSG00000166508" "MCM7" "A4D2A1; A4D2A2; E9PGN9; hsa:4176; P33993; Q15076; Q96D34; Q96GL1" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; Ciliary landscape; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the pre-replicative complex; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Unwinding of DNA" "12" "0" "1.004" "1.029" "1.032" "0.994" "1.052" "1.010" "1.003" "1.089" "1.021" "8211.3" "8240.2" "8451.2" "8477.1" "8161.8" "8638.7" "8297.5" "8235.8" "8940.9" "8382.3" "" "" "" "" "" "" "" "" "" "" "7382.8" "6667.7" "7644.4" "8274.8" "6735.3" "8638.7" "6212.9" "7274.4" "8000.2" "2992.2" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410325427073227732" "False" "High" "IsMasterProtein" "Cont_P68103" "Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1" "0.000" "True" "231.938" "63" "29" "253" "16" "462" "50.1" "9.01" "903.58" "29" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "100009189; 100137407; 100173928; 100415334; 100455760; 100583632; 100720380; 100860780; 100894850; 100978974; 101016039; 101102857; 101114018; 101120236; 101143481; 101427577; 101925273; 102283704; 102540473; 102729396; 102952660; 102986013; 103243896; 104657006; 104668174; 104669279; 104675330; 105064770; 105589208; 108529199; 108538073; 109248229; 109261840; 109563706; 1915; 282220; 403506; 493922; 494136; 574059; 716010" "ENSBGRG00000009070; ENSBIXG00000015018; ENSBIXG00005015547; ENSBMUG00000019814; ENSBTAG00000014534; ENSCABG00000013336; ENSCAFG00000002656; ENSCAFG00000054475; ENSCAFG00000056088; ENSCAFG00000057183; ENSCAFG00030004385; ENSCAFG00030013393; ENSCAFG00030013497; ENSCAFG00030026219; ENSCAFG00040018088; ENSCAFG00845012150; ENSCATG00000039727; ENSCCAG00000033087; ENSCHIG00000010087; ENSCJAG00000083200; ENSCPOG00000004067; ENSCSAG00000014041; ENSCWAG00000008166; ENSEASG00005004328; ENSEASG00005023174; ENSFCAG00000030977; ENSG00000156508; ENSGGOG00000025675; ENSLCNG00005010676; ENSMMUG00000004852; ENSNLEG00000035164; ENSOARG00000006149; ENSOARG00000007762; ENSOARG00000011616; ENSOCUG00000008481; ENSPANG00000006932; ENSPCTG00005022294; ENSPLOG00000016117; ENSPPAG00000038736; ENSPPYG00000016777; ENSPTEG00000025546; ENSPTIG00000007871; ENSPTRG00000018347; ENSRBIG00000028957; ENSRROG00000044652; ENSSSCG00005007871; ENSSSCG00015021824; ENSSSCG00035049336; ENSSSCG00060027448; ENSSSCG00065043427; ENSSSCG00070013256; ENSTGEG00000013204" "EEF1A; Eef1a1; EEF1A1; LOC102523342; LOC102540473; LOC105064770; LOC105879067; LOC111096123; LOC111152497; LOC112630422; LOC118356941; RABEFLA2" "A0A096NSJ4; A0A0D9RNJ1; A0A2I3HHP9; A0A2J8PVY3; A0A2J8RYS8; A0A2K5N7Z5; A0A2K5RPQ1; A0A2K6KG30; A0A2K6RQ54; A0A2R9BYN3; A0A2U3XB66; A0A2Y9F799; A0A2Y9HH84; A0A2Y9K0L0; A0A452E2H7; A0A485PKI5; A0A4W2G2H2; A0A4X1U102; A0A5N4BZH2; A0A663DJ63; A0A667H9L1; A0A6I9I937; A0A6J0YU90; A0A6J1ZA85; A0A6J3HMT0; A0A6P5CAS0; A0A6P6HZ37; A0A6P7EC07; A0A6P7EG13; A0A6P9FBB6; A0A811YU57; A0A8B7HCC5; A0A8B8RGI1; A0A8B9X6G1; A0A8C0H2M0; A0A8C0NJT4; A0A8C3W2U9; A0A8C4L5X9; A0A8C8XSK7; A0A8C9HVZ6; A0A8C9JCC1; A0A8D0I6I6; A0A8D2F6F8; A0A8D8FTM6; A0A8H2XW05; A0A8I3VX86; A0A8M1H472; A0A8U0UW05; A0A9L0JZA8; A0A9V1E3R7; A0A9W3GP67; A5PK01; A9X189; aju:106980206; B1MTF5; B7NZC3; biu:109563706; bom:102283704; bta:282220; C3PT41; caty:105589208; cfa:403506; cfr:102523342; chx:100860780; cjc:100415334; cjc:100894850; cpoc:100720380; csab:103243896; dnm:101427577; elk:111152497; F1RQG6; F2Z4P4; F6VFC8; F7AW94; fca:493922; G2HFA2; G3S518; ggo:101143481; H0V2B3; hsa:1915; L8I7U3; lww:102729396; mcc:716010; mcf:101925273; mmur:105879067; mpuf:101672541; nle:100583632; nsu:110583033; oas:101102857; oas:101114018; oas:101120236; ocu:100009189; P04719; P04720; P68103; P68104; P68105; panu:100137407; panu:101016039; pcad:102986013; pcoo:112862036; pon:100173928; pon:100455760; pps:100978974; ptg:102952660; ptr:494136; Q0PY11; Q2KJJ3; Q4R5K0; Q5NVF3; Q5R1X2; Q5R4R8; Q66RN5; Q6IPS9; Q6IQ15; rbb:108529199; rbb:108538073; rro:104657006; rro:104668174; rro:104669279; rro:104675330; ssc:574059; umr:103657393; vpc:102540473; W5PD15; zca:118356820; zca:118356941" "Translation factors; EGFR1 signaling pathway; Fragile X syndrome; 2q37 copy number variation syndrome; EGFR1 signaling pathway" "Neutrophil degranulation; Protein methylation; HSF1 activation; Eukaryotic Translation Elongation; Neutrophil degranulation; Protein methylation; Eukaryotic Translation Elongation; HSF1 activation; Neutrophil degranulation; Chaperone Mediated Autophagy; Protein methylation; HSF1 activation; Peptide chain elongation; SARS-CoV-1 modulates host translation machinery" "20" "16" "1.040" "1.008" "1.143" "0.970" "1.033" "0.996" "1.027" "1.036" "0.863" "22552.0" "23452.1" "22743.1" "25779.6" "21871.2" "23293.0" "22471.7" "23168.1" "23352.8" "19471.7" "" "" "" "" "" "" "" "" "" "" "20276.5" "18976.6" "20571.9" "25164.4" "18048.5" "23293.0" "16826.3" "20463.6" "20895.9" "6950.8" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5903683586191117105" "False" "High" "IsMasterProtein" "Q13200" "26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PSMD2 PE=1 SV=3" "0.000" "False" "230.244" "52" "39" "93" "39" "908" "100.1" "5.20" "341.25" "39" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01851, Pf17781, Pf18051" "5708" "ENSG00000175166" "PSMD2" "B4DX07; B4DXY1; E7EW34; E9PCS3; hsa:5708; Q12932; Q13200; Q15321; Q53XQ4; Q96I12" "Proteasome degradation; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "0.995" "1.011" "1.014" "0.949" "0.999" "0.970" "0.991" "1.028" "0.941" "8765.7" "8725.2" "8859.7" "8886.9" "8322.5" "8760.7" "8507.0" "8690.0" "9011.7" "8250.9" "" "" "" "" "" "" "" "" "" "" "7881.2" "7060.1" "8013.9" "8674.8" "6867.9" "8760.7" "6369.8" "7675.6" "8063.6" "2945.3" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5753903603639706733" "False" "High" "IsMasterProtein" "Q15021" "Condensin complex subunit 1 OS=Homo sapiens OX=9606 GN=NCAPD2 PE=1 SV=3" "0.000" "False" "229.874" "42" "50" "89" "50" "1401" "157.1" "6.61" "327.99" "50" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12717, Pf12922" "9918" "ENSG00000010292" "NCAPD2" "D3DUR4; hsa:9918; Q15021; Q8N6U3" "" "Condensation of Prometaphase Chromosomes" "1" "0" "1.044" "1.026" "1.004" "1.057" "0.987" "1.036" "1.033" "1.028" "1.449" "7135.4" "7447.8" "7321.5" "7166.9" "7538.8" "7044.3" "7389.3" "7371.0" "7334.9" "10339.5" "" "" "" "" "" "" "" "" "" "" "6415.4" "6026.5" "6622.6" "6995.9" "6221.2" "7044.3" "5532.9" "6510.6" "6563.2" "3690.9" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3453678624484122586" "False" "High" "IsMasterProtein" "Q8WUM4" "Programmed cell death 6-interacting protein OS=Homo sapiens OX=9606 GN=PDCD6IP PE=1 SV=1" "0.000" "False" "226.970" "51" "40" "89" "40" "868" "96.0" "6.52" "327.24" "40" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03097, Pf13949" "10015" "ENSG00000170248" "PDCD6IP" "C5MQH7; E9PFU1; hsa:10015; Q6NUS1; Q8WUM4; Q9BX86; Q9NUN0; Q9P2H2; Q9UKL5" "Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "Budding and maturation of HIV virion; Regulation of necroptotic cell death; Uptake and function of anthrax toxins" "5" "0" "0.984" "0.981" "1.022" "0.954" "0.933" "1.026" "0.979" "0.938" "1.474" "8930.1" "8789.0" "8761.7" "9128.4" "8518.3" "8329.1" "9159.6" "8744.2" "8377.5" "13159.7" "" "" "" "" "" "" "" "" "" "" "8029.0" "7111.7" "7925.3" "8910.6" "7029.5" "8329.1" "6858.5" "7723.4" "7496.1" "4697.6" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1612190288293860915" "False" "High" "IsMasterProtein" "P60842" "Eukaryotic initiation factor 4A-I OS=Homo sapiens OX=9606 GN=EIF4A1 PE=1 SV=1" "0.000" "False" "226.857" "64" "26" "142" "14" "406" "46.1" "5.48" "539.96" "26" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1973" "ENSG00000161960" "EIF4A1" "B2R6L8; D3DTP9; hsa:1973; J3QLC4; P04765; P60842; Q5U018; Q61516" "Translation factors; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Interferon type I signaling pathways" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ISG15 antiviral mechanism; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "13" "1.028" "1.043" "1.047" "1.017" "1.023" "1.036" "1.015" "1.048" "0.990" "12882.1" "13248.0" "13436.6" "13487.4" "13104.1" "13177.6" "13343.1" "13077.6" "13504.1" "12750.1" "" "" "" "" "" "" "" "" "" "" "11582.3" "10719.8" "12153.8" "13165.6" "10813.8" "13177.6" "9991.0" "11551.0" "12083.4" "4551.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8957423501143175457" "False" "High" "IsMasterProtein" "Cont_P81948" "Tubulin alpha-4A chain OS=Bos taurus OX=9913 GN=TUBA4A PE=1 SV=2" "0.000" "True" "226.073" "65" "23" "217" "6" "448" "49.9" "5.06" "801.31" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "100151951; 100302357; 100354352; 100400294; 100449357; 100734500; 100767686; 100995882; 101006121; 101095277; 101148853; 101379814; 101569770; 101606396; 101677236; 101838478; 101926805; 101969889; 102012828; 102177846; 102532857; 102746509; 102841369; 102928867; 102962068; 103007004; 103072784; 103110543; 103217904; 103261248; 103662744; 103727749; 104660054; 105064041; 105481257; 105504700; 105528059; 105587029; 105808789; 105857673; 105996598; 107138719; 107516732; 109265033; 109571050; 22145; 316531; 470654; 478918; 702583; 7277; 777775" "ENSANAG00000028048; ENSBIXG00005021445; ENSBMSG00010001061; ENSBTAG00000030974; ENSCAFG00000015209; ENSCAFG00020027000; ENSCAFG00030011006; ENSCAFG00845029842; ENSCANG00000024607; ENSCATG00000033332; ENSCGRG00001024425; ENSCHIG00000002435; ENSCJAG00000070762; ENSCLAG00000011603; ENSCPOG00000037151; ENSCSAG00000008100; ENSFCAG00000038881; ENSG00000127824; ENSGGOG00000023578; ENSJJAG00000011005; ENSLCNG00005009789; ENSMFAG00000007541; ENSMICG00000035827; ENSMLEG00000029671; ENSMMMG00000020450; ENSMMSG00000019327; ENSMMUG00000019628; ENSMNEG00000039170; ENSMSIG00000018170; ENSMUSG00000026202; ENSNGAG00000020443; ENSNLEG00000027445; ENSOARG00000020020; ENSOCUG00000026994; ENSPANG00000041659; ENSPCOG00000023925; ENSPEMG00000029240; ENSPLOG00000016209; ENSPPAG00000011142; ENSPPYG00000013203; ENSPSMG00000025346; ENSPSNG00000018656; ENSPTEG00000039375; ENSPTIG00000021758; ENSPTRG00000012949; ENSRNOG00000003597; ENSRNOG00055010434; ENSRNOG00060007884; ENSRNOG00065008885; ENSRROG00000044949; ENSSSCG00000016216; ENSSSCG00025016272; ENSSSCG00035020742; ENSSSCG00040017674; ENSSSCG00050039745; ENSSSCG00070016481; ENSSTOG00000019497; ENSSVLG00005016017; ENSTGEG00000012532; ENSTSYG00000011750; ENSUMAG00000018763; ENSUPAG00010012836; ENSVVUG00000025771" "LOC101334183; LOC102532857; LOC102746509; LOC103662744; LOC106970047; LOC109265033; LOC111143142; LOC111171848; LOC112411846; LOC112838391; LOC112872268; LOC112922524; LOC113920876; LOC114495658; LOC118898366; Tuba4a; TUBA4A" "A0A0D9R6X5; A0A1S2ZI83; A0A1S3GBQ2; A0A1U7Q653; A0A1U7TVH0; A0A286ZNY1; A0A2I2UZ20; A0A2I2YM80; A0A2J8NG28; A0A2J8TUH3; A0A2K5DHU1; A0A2K5HTH7; A0A2K5M1H8; A0A2K5Y6I3; A0A2K6D749; A0A2K6GBF8; A0A2K6RS93; A0A2R8ZC21; A0A2U3W3Z0; A0A2U3YH71; A0A2Y9IV09; A0A2Y9N2F1; A0A340WE79; A0A341CW34; A0A384AKZ1; A0A384C1E6; A0A3Q7QMN7; A0A3Q7SCG6; A0A452DNE3; A0A484GTP9; A0A485MVS4; A0A4W2GGR2; A0A4X1UG19; A0A5N3WUA1; A0A663D8Z2; A0A667GI79; A0A6D2XJT6; A0A6I9I9T5; A0A6I9L693; A0A6J1YN80; A0A6J2LL95; A0A6J3RLQ7; A0A6P3CX09; A0A6P3FIC2; A0A6P5D399; A0A6P6ISG9; A0A6P9F8Q5; A0A7J8JNJ1; A0A811ZBS6; A0A8B7EMV4; A0A8B7KBC2; A0A8B8XXA4; A0A8C0LT90; A0A8C0MZ87; A0A8C2N284; A0A8C2VS48; A0A8C5KB95; A0A8C6E681; A0A8C6EXI3; A0A8C6HJF8; A0A8C6RPC4; A0A8C8XN00; A0A8C9ASB4; A0A8C9CIF4; A0A8C9IX37; A0A8C9KT44; A0A8D2D621; A0A8D2K0Z6; A0A8D2KIE8; A0A8I3Q1H9; A0A8I5NZD6; A0A8U0N0J8; A0A9B0TPY2; A0A9V1FEX0; A0A9W3GNM5; A6JVZ9; A8MUB1; aju:106970047; B3KNQ6; biu:109571050; bta:777775; C5ISA2; caty:105587029; cfr:102522237; chx:102177846; cjc:100400294; cpoc:100734500; csyr:103261248; dle:111171848; dord:105996598; elk:111143142; F6QRE8; F7HZP3; fca:101095277; G1RDQ0; G1TR82; H0V3I8; H2P8P0; H2QJG6; hsa:7277; I3NHW3; K9IKB3; lww:102746509; maua:101838478; mcf:101926805; mmu:22145; mmur:105857673; mpuf:101677236; nasi:112411846; ngi:103727749; oas:100302357; ocu:100354352; oro:101379814; P05215; P68366; P68367; P68368; P81948; panu:101006121; pcoo:112872268; pdic:114495658; pon:100449357; pps:100995882; ptg:102962068; Q17QT1; Q3TY31; Q5E986; Q5XIF6; ray:107516732; rno:316531; rro:104660054; ssc:100151951; umr:103662744; vpc:102532857; vvp:112922524" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Platelet degranulation ; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Hedgehog 'off' state; Intraflagellar transport; COPI-mediated anterograde transport; The role of GTSE1 in G2/M progression after G2 checkpoint; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; PKR-mediated signaling; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Platelet degranulation ; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state; Platelet degranulation ; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; MHC class II antigen presentation; COPI-mediated anterograde transport; Separation of Sister Chromatids; Anchoring of the basal body to the plasma membrane; PKR-mediated signaling; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; AURKA Activation by TPX2; EML4 and NUDC in mitotic spindle formation; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recycling pathway of L1; Hedgehog 'off' state; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; The role of GTSE1 in G2/M progression after G2 checkpoint; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Platelet degranulation ; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; Resolution of Sister Chromatid Cohesion; Regulation of PLK1 Activity at G2/M Transition; The role of GTSE1 in G2/M progression after G2 checkpoint; MHC class II antigen presentation; RHO GTPases Activate Formins; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; Intraflagellar transport; Separation of Sister Chromatids; EML4 and NUDC in mitotic spindle formation; Hedgehog 'off' state; Loss of Nlp from mitotic centrosomes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Kinesins; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; RHO GTPases activate IQGAPs; Carboxyterminal post-translational modifications of tubulin; Aggrephagy; Sealing of the nuclear envelope (NE) by ESCRT-III; MHC class II antigen presentation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; COPI-independent Golgi-to-ER retrograde traffic; Anchoring of the basal body to the plasma membrane; Platelet degranulation ; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; COPI-dependent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Kinesins; PKR-mediated signaling; COPI-mediated anterograde transport; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Recruitment of NuMA to mitotic centrosomes; AURKA Activation by TPX2; Hedgehog 'off' state; Intraflagellar transport; Carboxyterminal post-translational modifications of tubulin; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Sealing of the nuclear envelope (NE) by ESCRT-III; Aggrephagy; Recycling pathway of L1; RHO GTPases activate IQGAPs; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane" "160" "0" "0.984" "0.969" "1.066" "0.990" "0.940" "1.054" "0.964" "0.933" "0.924" "2599.5" "2558.4" "2519.5" "2770.0" "2573.0" "2444.4" "2740.1" "2505.4" "2426.3" "2402.5" "" "" "" "" "" "" "" "" "" "" "2337.2" "2070.1" "2279.0" "2703.9" "2123.3" "2444.4" "2051.7" "2212.9" "2171.0" "857.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2402053168044673171" "False" "High" "IsMasterProtein" "P06576" "ATP synthase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1B PE=1 SV=3" "0.000" "False" "225.692" "64" "23" "104" "23" "529" "56.5" "5.40" "421.35" "23" "other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf02874" "506" "ENSG00000110955" "ATP5F1B" "A8K4X0; hsa:506; P06576; Q14283" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "8" "0" "1.035" "1.002" "1.017" "1.010" "1.018" "1.039" "1.002" "1.005" "0.789" "6167.3" "6381.5" "6180.2" "6272.5" "6226.2" "6276.2" "6408.4" "6182.1" "6199.7" "4863.6" "" "" "" "" "" "" "" "" "" "" "5545.0" "5163.7" "5590.2" "6122.9" "5137.9" "6276.2" "4798.5" "5460.4" "5547.4" "1736.2" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535556334998408323" "False" "High" "IsMasterProtein" "P49411" "Elongation factor Tu, mitochondrial OS=Homo sapiens OX=9606 GN=TUFM PE=1 SV=3" "0.000" "False" "225.067" "64" "28" "110" "28" "455" "49.8" "7.61" "459.09" "28" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "7284" "ENSG00000178952" "TUFM" "hsa:7284; O15276; P49411" "16p11.2 distal deletion syndrome" "Mitochondrial translation elongation; SARS-CoV-2 modulates autophagy" "3" "0" "1.035" "1.073" "1.042" "1.009" "1.005" "1.027" "1.033" "1.045" "1.144" "9859.9" "10203.6" "10579.0" "10278.8" "9951.6" "9904.8" "10126.7" "10188.8" "10304.1" "11276.6" "" "" "" "" "" "" "" "" "" "" "8865.0" "8256.4" "9569.0" "10033.5" "8212.3" "9904.8" "7582.6" "8999.4" "9220.0" "4025.4" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-729542664091126034" "False" "High" "IsMasterProtein" "Q93008" "Ubiquitin carboxyl-terminal hydrolase 9X OS=Homo sapiens OX=9606 GN=USP9X PE=1 SV=4" "0.000" "False" "224.849" "24" "57" "87" "56" "2554" "290.3" "5.80" "305.62" "57" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00443, Pf12030" "8239" "ENSG00000124486" "USP9X" "hsa:8239; O75550; Q8WWT3; Q8WX12; Q93008" "Ciliopathies; Bardet-Biedl syndrome" "Ub-specific processing proteases; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Peroxisomal protein import; RHOV GTPase cycle; RHOU GTPase cycle" "9" "1" "1.034" "0.964" "0.958" "0.999" "0.932" "0.999" "0.947" "0.941" "1.066" "6976.6" "7213.1" "6726.3" "6680.8" "6969.8" "6503.3" "6969.3" "6608.6" "6562.7" "7440.5" "" "" "" "" "" "" "" "" "" "" "6272.6" "5836.6" "6084.2" "6521.4" "5751.6" "6503.3" "5218.4" "5837.1" "5872.3" "2656.0" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6210925912035566058" "False" "High" "IsMasterProtein" "Q14980" "Nuclear mitotic apparatus protein 1 OS=Homo sapiens OX=9606 GN=NUMA1 PE=1 SV=2" "0.000" "False" "224.496" "29" "54" "81" "54" "2115" "238.1" "5.78" "309.04" "54" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21670" "4926" "ENSG00000137497" "NUMA1" "H0YH75; hsa:4926; Q14980; Q14981; Q9BTE9" "Ectoderm differentiation; Ectoderm differentiation; 8p23.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Mitotic Prophase" "5" "0" "1.129" "1.067" "1.043" "1.134" "1.078" "1.152" "1.073" "0.994" "1.133" "4949.3" "5588.8" "5279.9" "5163.8" "5614.6" "5335.6" "5702.9" "5309.7" "4919.3" "5606.8" "" "" "" "" "" "" "" "" "" "" "4449.9" "4522.3" "4775.9" "5040.6" "4633.3" "5335.6" "4270.2" "4689.9" "4401.7" "2001.5" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-915816600694735360" "False" "High" "IsMasterProtein" "O14980" "Exportin-1 OS=Homo sapiens OX=9606 GN=XPO1 PE=1 SV=1" "0.000" "False" "222.925" "39" "36" "99" "36" "1071" "123.3" "6.06" "348.48" "36" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf08767, Pf18777, Pf18784, Pf18787" "7514" "ENSG00000082898" "XPO1" "A6NL14; A8K1K5; D6W5E2; hsa:7514; O14980; Q63HP8; Q68CP3; Q99433" "eIF5A regulation in response to inhibition of the nuclear export system; 22q11.2 copy number variation syndrome" "Separation of Sister Chromatids; MAPK6/MAPK4 signaling; NPAS4 regulates expression of target genes; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Heme signaling; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; Downregulation of TGF-beta receptor signaling; HuR (ELAVL1) binds and stabilizes mRNA; Cyclin A/B1/B2 associated events during G2/M transition; Maturation of hRSV A proteins" "19" "0" "1.017" "0.980" "0.985" "1.008" "0.898" "1.043" "0.993" "0.945" "1.139" "8302.5" "8444.4" "8139.6" "8175.9" "8371.3" "7454.8" "8662.0" "8244.1" "7845.3" "9456.9" "" "" "" "" "" "" "" "" "" "" "7464.7" "6832.9" "7362.5" "7980.8" "6908.2" "7454.8" "6485.9" "7281.7" "7019.9" "3375.8" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2468696703933973892" "False" "High" "IsMasterProtein" "P23921" "Ribonucleoside-diphosphate reductase large subunit OS=Homo sapiens OX=9606 GN=RRM1 PE=1 SV=1" "0.000" "False" "222.515" "46" "33" "98" "33" "792" "90.0" "7.15" "374.11" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00317, Pf02867, Pf03477" "6240" "ENSG00000167325" "RRM1" "hsa:6240; P23921; Q9UNN2" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "4" "0" "0.993" "1.121" "1.020" "1.007" "1.098" "0.985" "0.986" "1.142" "0.909" "7837.5" "7781.7" "8787.5" "7995.7" "7891.2" "8606.0" "7716.3" "7731.1" "8951.0" "7127.0" "" "" "" "" "" "" "" "" "" "" "7046.7" "6296.6" "7948.5" "7804.9" "6511.9" "8606.0" "5777.7" "6828.6" "8009.3" "2544.2" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602445909866352508" "False" "High" "IsMasterProtein" "P19338" "Nucleolin OS=Homo sapiens OX=9606 GN=NCL PE=1 SV=3" "0.000" "False" "220.650" "51" "51" "188" "50" "710" "76.6" "4.70" "577.31" "51" "developmental processes;other biological processes" "plasma membrane;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "4691" "ENSG00000115053" "NCL" "hsa:4691; P19338; Q53SK1; Q8NB06; Q9UCF0; Q9UDG1" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "Major pathway of rRNA processing in the nucleolus and cytosol; Respiratory syncytial virus (RSV) attachment and entry" "4" "1" "0.953" "0.887" "0.858" "0.849" "1.059" "0.841" "0.921" "0.840" "0.674" "21347.8" "20334.8" "18936.8" "18321.0" "18119.3" "22610.4" "17946.2" "19667.8" "17932.0" "14398.2" "" "" "" "" "" "" "" "" "" "" "19193.8" "16454.2" "17129.0" "17883.9" "14952.4" "22610.4" "13437.7" "17371.8" "16045.4" "5139.7" "44" "44" "44" "44" "44" "44" "44" "44" "44" "44" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619416957405686977" "False" "High" "IsMasterProtein" "P49321" "Nuclear autoantigenic sperm protein OS=Homo sapiens OX=9606 GN=NASP PE=1 SV=2" "0.000" "False" "220.512" "49" "34" "119" "33" "788" "85.2" "4.30" "435.91" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10516" "4678" "ENSG00000132780" "NASP" "A8K6H2; B4DQP3; D3DQ07; F5H3J2; hsa:4678; P49321; Q53GW5; Q5T622; Q5T625; Q96A69; Q9BTW2" "" "" "0" "0" "0.925" "0.975" "0.947" "0.929" "1.040" "0.915" "0.985" "0.977" "0.791" "11341.9" "10493.5" "11060.5" "10743.7" "10538.3" "11790.4" "10383.2" "11168.8" "11081.3" "8969.7" "" "" "" "" "" "" "" "" "" "" "10197.4" "8491.0" "10004.6" "10487.3" "8696.4" "11790.4" "7774.7" "9865.0" "9915.5" "3201.9" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646758734319931850" "False" "High" "IsMasterProtein" "Q16555" "Dihydropyrimidinase-related protein 2 OS=Homo sapiens OX=9606 GN=DPYSL2 PE=1 SV=1" "0.000" "False" "219.402" "72" "28" "113" "27" "572" "62.3" "6.38" "448.40" "28" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf01979" "1808" "ENSG00000092964" "DPYSL2" "A8K5H2; B4DR31; D3DSS7; hsa:1808; O00424; Q16555" "Microtubule cytoskeleton regulation; Brain-derived neurotrophic factor (BDNF) signaling pathway" "Recycling pathway of L1; CRMPs in Sema3A signaling" "4" "0" "1.014" "0.949" "0.994" "1.006" "0.933" "0.991" "0.986" "0.971" "0.791" "8453.8" "8575.1" "8020.9" "8407.1" "8505.0" "7885.2" "8378.1" "8331.7" "8206.3" "6687.8" "" "" "" "" "" "" "" "" "" "" "7600.8" "6938.6" "7255.1" "8206.5" "7018.5" "7885.2" "6273.3" "7359.1" "7342.9" "2387.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6576828257658518084" "False" "High" "IsMasterProtein" "Q9BQE3" "Tubulin alpha-1C chain OS=Homo sapiens OX=9606 GN=TUBA1C PE=1 SV=1" "0.000" "False" "218.562" "65" "24" "244" "3" "449" "49.9" "5.10" "871.41" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84790" "ENSG00000167553" "TUBA1C" "hsa:84790; Q9BQE3" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease; HDAC6 interactions in the central nervous system" "HCMV Early Events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Sealing of the nuclear envelope (NE) by ESCRT-III; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "37" "1" "1.022" "0.983" "1.140" "1.043" "1.034" "1.090" "1.068" "1.079" "0.915" "836.7" "854.9" "822.1" "953.8" "872.6" "865.1" "911.7" "893.4" "902.4" "765.4" "" "" "" "" "" "" "" "" "" "" "752.2" "691.8" "743.6" "931.1" "720.1" "865.1" "682.7" "789.1" "807.4" "273.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5211801014996619812" "False" "High" "IsMasterProtein" "O43143" "ATP-dependent RNA helicase DHX15 OS=Homo sapiens OX=9606 GN=DHX15 PE=1 SV=2" "0.000" "False" "218.487" "50" "35" "101" "34" "795" "90.9" "7.46" "367.09" "35" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "1665" "ENSG00000109606" "DHX15" "hsa:1665; O43143; Q9NQT7" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "1" "1.083" "1.068" "1.023" "1.086" "1.050" "1.046" "1.049" "1.040" "0.676" "6950.6" "7525.5" "7423.2" "7110.6" "7545.5" "7298.4" "7267.5" "7288.9" "7225.9" "4698.2" "" "" "" "" "" "" "" "" "" "" "6249.3" "6089.3" "6714.6" "6941.0" "6226.7" "7298.4" "5441.7" "6438.0" "6465.6" "1677.1" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2064522308959827201" "False" "High" "IsMasterProtein" "Q92841" "Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens OX=9606 GN=DDX17 PE=1 SV=2" "0.000" "False" "218.251" "45" "35" "86" "27" "729" "80.2" "8.27" "308.34" "35" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "10521" "ENSG00000100201" "DDX17" "B1AHM0; H3BLZ8; hsa:10521; Q69YT1; Q6ICD6; Q92841" "Novel intracellular components of RIG-I-like receptor pathway" "SUMOylation of transcription cofactors" "2" "10" "0.999" "0.928" "0.981" "0.964" "0.978" "0.937" "0.966" "0.897" "0.859" "7495.4" "7487.7" "6959.0" "7349.8" "7221.9" "7332.3" "7025.5" "7242.8" "6726.3" "6440.6" "" "" "" "" "" "" "" "" "" "" "6739.1" "6058.8" "6294.6" "7174.4" "5959.7" "7332.3" "5260.5" "6397.3" "6018.6" "2299.1" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1873273852874603797" "False" "High" "IsMasterProtein" "Q709C8" "Intermembrane lipid transfer protein VPS13C OS=Homo sapiens OX=9606 GN=VPS13C PE=1 SV=1" "0.000" "False" "217.309" "19" "60" "72" "60" "3753" "422.1" "6.83" "256.84" "60" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "54832" "ENSG00000129003" "VPS13C" "hsa:54832; Q6ISR4; Q702P2; Q702P3; Q709C8; Q709C9; Q9NXN8; Q9P2C6" "" "" "0" "0" "1.090" "1.045" "1.008" "1.011" "0.978" "1.032" "1.014" "1.048" "0.993" "4838.6" "5273.8" "5055.4" "4879.5" "4890.6" "4730.6" "4992.7" "4905.9" "5072.8" "4804.1" "" "" "" "" "" "" "" "" "" "" "4350.3" "4267.4" "4572.8" "4763.1" "4035.9" "4730.6" "3738.4" "4333.2" "4539.1" "1714.9" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2914348929085593862" "False" "High" "IsMasterProtein" "Q96F07" "Cytoplasmic FMR1-interacting protein 2 OS=Homo sapiens OX=9606 GN=CYFIP2 PE=1 SV=2" "0.000" "False" "216.944" "37" "46" "84" "30" "1278" "148.3" "7.31" "287.74" "46" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05994, Pf07159" "26999" "ENSG00000055163" "CYFIP2" "A6NLT2; D3DQJ3; hsa:26999; Q53EN5; Q96F07; Q9NTK4; Q9ULQ2; Q9UN29" "Fragile X syndrome; Regulation of actin cytoskeleton" "RAC1 GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "7" "16" "1.009" "0.996" "0.944" "0.995" "0.893" "0.951" "0.948" "0.991" "0.820" "8600.0" "8673.3" "8565.7" "8114.8" "8555.9" "7684.1" "8174.8" "8152.6" "8523.5" "7048.7" "" "" "" "" "" "" "" "" "" "" "7732.3" "7018.1" "7748.0" "7921.1" "7060.5" "7684.1" "6121.1" "7200.9" "7626.8" "2516.2" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5279545747934132258" "False" "High" "IsMasterProtein" "P04350" "Tubulin beta-4A chain OS=Homo sapiens OX=9606 GN=TUBB4A PE=1 SV=2" "0.000" "False" "216.430" "66" "23" "238" "3" "444" "49.6" "4.88" "679.87" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "10382" "ENSG00000104833" "TUBB4A" "B3KQP4; hsa:10382; P04350; Q969E5" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "RHO GTPases Activate Formins; Intraflagellar transport; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "41" "2" "1.002" "1.004" "0.999" "1.019" "1.074" "1.088" "1.069" "1.101" "0.871" "303.4" "304.1" "304.7" "303.2" "309.1" "325.9" "330.1" "324.2" "334.1" "264.1" "" "" "" "" "" "" "" "" "" "" "272.8" "246.0" "275.6" "296.0" "255.1" "325.9" "247.2" "286.3" "298.9" "94.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9171365705039643338" "False" "High" "IsMasterProtein" "P45974" "Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens OX=9606 GN=USP5 PE=1 SV=2" "0.000" "False" "214.846" "40" "31" "94" "30" "858" "95.7" "5.03" "361.12" "31" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8078" "ENSG00000111667" "USP5" "D3DUS7; D3DUS8; hsa:8078; P45974; Q96J22" "IL-18 signaling pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Ub-specific processing proteases" "3" "1" "1.033" "1.012" "0.995" "1.037" "0.946" "1.021" "1.015" "1.007" "0.825" "9118.8" "9417.0" "9226.4" "9074.4" "9455.4" "8625.2" "9306.9" "9257.9" "9180.6" "7523.7" "" "" "" "" "" "" "" "" "" "" "8198.7" "7619.9" "8345.6" "8857.9" "7802.8" "8625.2" "6968.8" "8177.2" "8214.7" "2685.8" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6011940264998513028" "False" "High" "IsMasterProtein" "O00429" "Dynamin-1-like protein OS=Homo sapiens OX=9606 GN=DNM1L PE=1 SV=2" "0.000" "False" "214.466" "56" "40" "94" "40" "736" "81.8" "6.81" "335.44" "40" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00350, Pf01031, Pf02212" "10059" "ENSG00000087470" "DNM1L" "A8K4X9; B4DGC9; B4DSU8; G8JLD5; hsa:10059; J3KPI2; O00429; O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2" "Synaptic vesicle pathway; CAMKK2 pathway" "Apoptotic execution phase" "3" "0" "1.005" "1.021" "1.005" "1.019" "1.004" "1.011" "1.022" "1.009" "0.842" "6890.6" "6923.3" "7037.3" "6923.1" "7019.9" "6919.7" "6969.0" "7044.0" "6949.4" "5801.9" "" "" "" "" "" "" "" "" "" "" "6195.3" "5602.1" "6365.5" "6757.9" "5793.0" "6919.7" "5218.2" "6221.7" "6218.2" "2071.1" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2006906941817689569" "False" "High" "IsMasterProtein" "Q9Y520" "Protein PRRC2C OS=Homo sapiens OX=9606 GN=PRRC2C PE=1 SV=4" "0.000" "False" "213.513" "21" "52" "77" "49" "2896" "316.7" "9.13" "268.90" "52" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "" "Pf07001" "23215" "ENSG00000117523" "PRRC2C" "hsa:23215; Q05DM8; Q49A39; Q6PD54; Q9H2N2; Q9HA05; Q9NSM8; Q9NXL3; Q9UF29; Q9UPQ6; Q9Y520" "VEGFA-VEGFR2 signaling" "" "1" "2" "0.983" "0.970" "0.975" "0.987" "1.076" "1.021" "0.959" "0.912" "0.765" "7874.8" "7737.4" "7635.2" "7681.7" "7775.1" "8477.2" "8039.9" "7551.7" "7182.5" "6021.2" "" "" "" "" "" "" "" "" "" "" "7080.2" "6260.9" "6906.3" "7498.4" "6416.1" "8477.2" "6020.1" "6670.2" "6426.9" "2149.4" "43" "43" "43" "43" "43" "43" "43" "43" "43" "43" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-951770295276680131" "False" "High" "IsMasterProtein" "P09874" "Poly [ADP-ribose] polymerase 1 OS=Homo sapiens OX=9606 GN=PARP1 PE=1 SV=4" "0.000" "False" "213.034" "42" "41" "86" "41" "1014" "113.0" "8.88" "304.72" "41" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00644, Pf00645, Pf02877, Pf05406, Pf08063, Pf21728" "142" "ENSG00000143799" "PARP1" "B1ANJ4; hsa:142; P09874; Q8IUZ9" "Corticotropin-releasing hormone signaling pathway; Nanoparticle triggered regulated necrosis; Fas ligand pathway and stress induction of heat shock proteins; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Breast cancer pathway; Acute viral myocarditis; Joubert syndrome; Male infertility; Base excision repair; IL-18 signaling pathway; DNA repair pathways, full network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Progeria-associated lipodystrophy; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through MMEJ (alt-NHEJ); DNA Damage Recognition in GG-NER; vRNA Synthesis; POLB-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER" "25" "0" "0.886" "0.871" "0.842" "0.825" "1.015" "0.870" "0.788" "0.844" "1.219" "9649.7" "8546.0" "8402.1" "8124.3" "7956.3" "9794.3" "8395.5" "7603.7" "8141.3" "11767.7" "" "" "" "" "" "" "" "" "" "" "8676.0" "6915.1" "7600.0" "7930.5" "6565.6" "9794.3" "6286.4" "6716.1" "7284.7" "4200.7" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4752916691292977805" "False" "High" "IsMasterProtein" "Q15057" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ACAP2 PE=1 SV=3" "0.000" "False" "212.953" "55" "33" "76" "32" "778" "88.0" "6.80" "287.01" "33" "transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf16746" "23527" "ENSG00000114331" "ACAP2" "A8K2V4; hsa:23527; Q15057; Q8N5Z8; Q9UQR3" "" "" "0" "0" "1.038" "1.017" "1.012" "1.044" "0.978" "1.028" "1.030" "1.021" "0.975" "6618.8" "6870.0" "6729.7" "6700.5" "6910.2" "6471.7" "6803.7" "6820.2" "6758.5" "6453.1" "" "" "" "" "" "" "" "" "" "" "5951.0" "5559.0" "6087.2" "6540.6" "5702.4" "6471.7" "5094.4" "6024.0" "6047.5" "2303.6" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2859585786570282431" "False" "High" "IsMasterProtein" "P08237" "ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens OX=9606 GN=PFKM PE=1 SV=2" "0.000" "False" "212.033" "49" "31" "91" "28" "780" "85.1" "7.99" "361.40" "31" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "kinase activity;other molecular function" "Pf00365" "5213" "ENSG00000152556" "PFKM" "hsa:5213; J3KNX3; P08237; Q16814; Q16815; Q6ZTT1" "Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Insulin signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis" "6" "3" "1.032" "0.958" "0.959" "1.001" "0.907" "0.975" "0.981" "1.016" "0.766" "8074.2" "8336.5" "7734.2" "7744.5" "8081.3" "7319.5" "7874.8" "7919.1" "8203.1" "6186.7" "" "" "" "" "" "" "" "" "" "" "7259.5" "6745.6" "6995.8" "7559.8" "6668.8" "7319.5" "5896.5" "6994.6" "7340.1" "2208.5" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4660808662127601060" "False" "High" "IsMasterProtein" "Q9NR09" "Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3" "0.000" "False" "211.963" "14" "57" "74" "57" "4857" "529.9" "6.05" "270.25" "57" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00179, Pf00653, Pf12356" "57448" "ENSG00000115760" "BIRC6" "hsa:57448; Q9NR09; Q9ULD1" "" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "2" "0" "1.010" "0.964" "0.955" "1.005" "0.922" "1.023" "0.986" "0.945" "0.917" "5174.0" "5223.9" "4985.4" "4942.9" "5199.1" "4770.2" "5291.7" "5103.7" "4886.9" "4742.8" "" "" "" "" "" "" "" "" "" "" "4652.0" "4227.0" "4509.4" "4824.9" "4290.4" "4770.2" "3962.3" "4507.9" "4372.7" "1693.0" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7637669709604963095" "False" "High" "IsMasterProtein" "Q12888" "TP53-binding protein 1 OS=Homo sapiens OX=9606 GN=TP53BP1 PE=1 SV=2" "0.000" "False" "209.811" "30" "45" "64" "45" "1972" "213.4" "4.70" "256.96" "45" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09038, Pf18428" "7158" "ENSG00000067369" "TP53BP1" "F8VY86; hsa:7158; Q12888; Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4" "ATM signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; SUMOylation of transcription factors; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "0.982" "0.988" "0.973" "1.002" "0.987" "1.010" "0.966" "0.996" "1.388" "5882.6" "5778.2" "5811.1" "5722.6" "5892.6" "5806.6" "5941.3" "5684.4" "5859.3" "8164.5" "" "" "" "" "" "" "" "" "" "" "5289.1" "4675.5" "5256.3" "5586.1" "4862.7" "5806.6" "4448.7" "5020.8" "5242.9" "2914.5" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7845595134204648988" "False" "High" "IsMasterProtein" "Q8NE71" "ATP-binding cassette sub-family F member 1 OS=Homo sapiens OX=9606 GN=ABCF1 PE=1 SV=2" "0.000" "False" "209.783" "45" "33" "69" "31" "845" "95.9" "6.80" "289.01" "33" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00005" "23" "ENSG00000204574; ENSG00000206490; ENSG00000225989; ENSG00000231129; ENSG00000232169; ENSG00000236149; ENSG00000236342" "ABCF1" "A2BF75; hsa:23; O14897; Q69YP6; Q8NE71" "IL-18 signaling pathway" "ABC-family proteins mediated transport" "2" "0" "1.028" "1.007" "0.976" "1.017" "0.987" "0.979" "0.989" "1.034" "0.818" "6545.6" "6730.8" "6590.6" "6390.1" "6654.9" "6459.4" "6409.3" "6472.7" "6771.0" "5356.5" "" "" "" "" "" "" "" "" "" "" "5885.1" "5446.3" "5961.4" "6237.7" "5491.8" "6459.4" "4799.2" "5717.1" "6058.6" "1912.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7238306351176714360" "False" "High" "IsMasterProtein" "Q14974" "Importin subunit beta-1 OS=Homo sapiens OX=9606 GN=KPNB1 PE=1 SV=2" "0.000" "False" "209.515" "39" "29" "92" "29" "876" "97.1" "4.78" "355.69" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf03810" "3837" "ENSG00000108424" "KPNB1" "B7ZAV6; D3DTT3; hsa:3837; Q14637; Q14974; Q53XN2; Q96J27" "Sterol regulatory element-binding proteins (SREBP) signaling; 22q11.2 copy number variation syndrome" "Neutrophil degranulation; Apoptosis induced DNA fragmentation; Interferon alpha/beta signaling; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Nuclear import of Rev protein; Regulation of cholesterol biosynthesis by SREBP (SREBF); SARS-CoV-1 activates/modulates innate immune responses; Assembly of the ORC complex at the origin of replication; Initiation of Nuclear Envelope (NE) Reformation; Postmitotic nuclear pore complex (NPC) reformation; Inhibition of nitric oxide production" "15" "0" "1.017" "0.981" "1.007" "1.032" "0.943" "1.041" "0.994" "0.964" "1.264" "7834.4" "7965.5" "7683.6" "7888.6" "8084.4" "7387.6" "8155.6" "7787.0" "7551.3" "9904.6" "" "" "" "" "" "" "" "" "" "" "7043.9" "6445.4" "6950.1" "7700.4" "6671.4" "7387.6" "6106.7" "6878.0" "6756.8" "3535.7" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256091368978195991" "False" "High" "IsMasterProtein" "Q32MZ4" "Leucine-rich repeat flightless-interacting protein 1 OS=Homo sapiens OX=9606 GN=LRRFIP1 PE=1 SV=2" "0.000" "False" "209.000" "42" "29" "79" "28" "808" "89.2" "4.65" "323.35" "29" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09738" "9208" "ENSG00000124831" "LRRFIP1" "E9PGZ2; hsa:9208; O75766; O75799; Q32MZ4; Q32MZ5; Q53T49; Q6PKG2; Q9Y607" "IL-18 signaling pathway; 2q37 copy number variation syndrome" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "5" "2" "0.910" "0.913" "0.932" "0.942" "0.918" "0.952" "0.969" "0.908" "0.869" "8053.3" "7331.3" "7356.6" "7504.0" "7586.6" "7396.3" "7665.5" "7801.8" "7308.8" "6998.3" "" "" "" "" "" "" "" "" "" "" "7240.7" "5932.2" "6654.3" "7325.0" "6260.6" "7396.3" "5739.8" "6891.1" "6539.9" "2498.2" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3269209104434095274" "False" "High" "IsMasterProtein" "P40227" "T-complex protein 1 subunit zeta OS=Homo sapiens OX=9606 GN=CCT6A PE=1 SV=3" "0.000" "False" "208.143" "62" "33" "119" "27" "531" "58.0" "6.68" "445.67" "33" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00118" "908" "ENSG00000146731" "CCT6A" "A6NCD2; hsa:908; P40227; Q3KP28; Q75LP4; Q96S46" "16p11.2 proximal deletion syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; RHOBTB2 GTPase cycle; Folding of actin by CCT/TriC" "7" "7" "1.028" "0.983" "1.051" "0.999" "0.970" "0.986" "1.038" "1.034" "0.835" "10474.2" "10769.1" "10300.3" "11012.5" "10466.5" "10154.8" "10323.0" "10875.8" "10826.2" "8750.2" "" "" "" "" "" "" "" "" "" "" "9417.3" "8714.0" "9317.0" "10749.8" "8637.1" "10154.8" "7729.6" "9606.2" "9687.2" "3123.6" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2847148615950550488" "False" "High" "IsMasterProtein" "P20700" "Lamin-B1 OS=Homo sapiens OX=9606 GN=LMNB1 PE=1 SV=2" "0.000" "False" "207.634" "59" "31" "80" "29" "586" "66.4" "5.16" "325.17" "31" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00038, Pf00932" "4001" "ENSG00000113368" "LMNB1" "B2R6J6; hsa:4001; P20700; Q3SYN7; Q96EI6" "Fas ligand pathway and stress induction of heat shock proteins; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "RHOD GTPase cycle; RHOF GTPase cycle; Meiotic synapsis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina; Breakdown of the nuclear lamina; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "14" "2" "1.012" "0.849" "1.032" "1.084" "0.878" "1.065" "1.010" "0.852" "0.641" "7377.6" "7468.4" "6260.2" "7611.8" "7995.4" "6480.6" "7857.5" "7450.0" "6284.3" "4731.9" "" "" "" "" "" "" "" "" "" "" "6633.2" "6043.2" "5662.6" "7430.2" "6598.0" "6480.6" "5883.5" "6580.4" "5623.1" "1689.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978266596079071295" "False" "High" "IsMasterProtein" "Q01518" "Adenylyl cyclase-associated protein 1 OS=Homo sapiens OX=9606 GN=CAP1 PE=1 SV=5" "0.000" "False" "206.581" "55" "26" "157" "12" "475" "51.9" "8.06" "536.54" "26" "cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "10487" "ENSG00000131236" "CAP1" "hsa:10487; Q01518; Q53HR7; Q5T0S1; Q5T0S2; Q6I9U6" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Complement system in neuronal development and plasticity; Opioid receptor pathways" "Neutrophil degranulation; Platelet degranulation ; Role of ABL in ROBO-SLIT signaling" "7" "16" "1.014" "1.014" "1.044" "0.961" "1.000" "0.995" "1.001" "1.013" "0.752" "14256.1" "14454.4" "14449.6" "14883.1" "13693.7" "14261.4" "14185.5" "14277.5" "14435.2" "10726.5" "" "" "" "" "" "" "" "" "" "" "12817.6" "11696.0" "13070.1" "14527.9" "11300.3" "14261.4" "10621.8" "12610.8" "12916.5" "3829.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4900440247780228765" "False" "High" "IsMasterProtein" "Q13616" "Cullin-1 OS=Homo sapiens OX=9606 GN=CUL1 PE=1 SV=2" "0.000" "False" "206.231" "56" "43" "84" "43" "776" "89.6" "8.00" "321.38" "43" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8454" "ENSG00000055130" "CUL1" "D3DWG3; hsa:8454; O60719; Q08AL6; Q13616; Q8IYW1" "Cell cycle; TNF-alpha signaling pathway; Parkin-ubiquitin proteasomal system pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; Pleural mesothelioma; Notch signaling pathway" "Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Circadian Clock; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Regulation of PLK1 Activity at G2/M Transition; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "41" "0" "1.029" "1.014" "0.973" "1.008" "0.984" "0.948" "0.973" "1.016" "0.807" "9265.1" "9534.7" "9398.2" "9011.6" "9337.6" "9117.4" "8784.5" "9016.5" "9409.9" "7479.1" "" "" "" "" "" "" "" "" "" "" "8330.3" "7715.2" "8501.0" "8796.6" "7705.5" "9117.4" "6577.6" "7964.0" "8419.9" "2669.8" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8288854614025876019" "False" "High" "IsMasterProtein" "P62258" "14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1" "0.000" "False" "205.457" "76" "25" "251" "22" "255" "29.2" "4.74" "862.88" "25" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00244" "7531" "ENSG00000108953; ENSG00000274474" "YWHAE" "B3KY71; D3DTH5; hsa:7531; P29360; P42655; P62258; Q4VJB6; Q53XZ5; Q63631; Q7M4R4" "Cell cycle; Myometrial relaxation and contraction pathways; VEGFA-VEGFR2 signaling; Calcium regulation in cardiac cells; 17p13.3 (YWHAE) copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; Regulation of HSF1-mediated heat shock response; RAB GEFs exchange GTP for GDP on RABs; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by Hippo; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; HSF1 activation; NADE modulates death signalling" "26" "4" "0.969" "0.964" "1.031" "0.984" "0.947" "0.971" "0.992" "0.975" "0.786" "23855.2" "23107.2" "23006.5" "24589.5" "23464.3" "22586.7" "23173.6" "23668.6" "23259.2" "18754.4" "" "" "" "" "" "" "" "" "" "" "21448.2" "18697.5" "20810.1" "24002.8" "19363.1" "22586.7" "17351.8" "20905.7" "20812.2" "6694.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3292354779633865334" "False" "High" "IsMasterProtein" "A5YKK6" "CCR4-NOT transcription complex subunit 1 OS=Homo sapiens OX=9606 GN=CNOT1 PE=1 SV=2" "0.000" "False" "204.786" "25" "51" "73" "51" "2376" "266.8" "7.11" "242.27" "51" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04054, Pf12842, Pf16415, Pf16417, Pf16418" "23019" "ENSG00000125107" "CNOT1" "A5YKK6; hsa:23019; Q68DX7; Q7Z3K2; Q8IWB8; Q8TB53; Q9BVZ6; Q9UFR8; Q9UI27; Q9Y2L0" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.036" "1.037" "0.984" "1.021" "0.970" "1.024" "0.972" "0.975" "1.205" "4507.2" "4668.6" "4674.6" "4434.8" "4599.8" "4373.9" "4616.0" "4381.5" "4395.5" "5429.2" "" "" "" "" "" "" "" "" "" "" "4052.4" "3777.7" "4228.3" "4329.0" "3795.8" "4373.9" "3456.3" "3870.0" "3933.1" "1938.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4784462983212685670" "False" "High" "IsMasterProtein" "Q96KP4" "Cytosolic non-specific dipeptidase OS=Homo sapiens OX=9606 GN=CNDP2 PE=1 SV=2" "0.000" "False" "204.375" "73" "29" "73" "29" "475" "52.8" "5.97" "309.75" "29" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf01546, Pf07687" "55748" "ENSG00000133313" "CNDP2" "B3KUG4; hsa:55748; Q8WY59; Q96KP4; Q9BQ94; Q9NVB4; V9HWE5" "" "Glutathione synthesis and recycling; Paracetamol ADME" "2" "0" "1.015" "0.976" "1.128" "0.996" "0.987" "1.039" "0.940" "0.976" "0.991" "6700.3" "6801.5" "6539.5" "7556.5" "6674.5" "6610.7" "6961.1" "6301.6" "6538.5" "6641.2" "" "" "" "" "" "" "" "" "" "" "6024.2" "5503.5" "5915.2" "7376.2" "5507.9" "6610.7" "5212.3" "5566.0" "5850.6" "2370.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773459124454051332" "False" "High" "IsMasterProtein" "P49915" "GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=GMPS PE=1 SV=1" "0.000" "False" "203.761" "55" "36" "91" "36" "693" "76.7" "6.87" "346.43" "36" "other metabolic processes" "cytosol" "other molecular function" "Pf00117, Pf00958, Pf02540" "8833" "ENSG00000163655" "GMPS" "A8K639; B4DXV7; F8W720; hsa:8833; P49915" "" "Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "2" "0" "0.973" "0.999" "1.013" "0.965" "0.955" "0.994" "0.962" "0.985" "1.027" "9971.4" "9701.5" "9960.9" "10102.5" "9627.1" "9521.1" "9908.0" "9595.6" "9819.0" "10243.0" "" "" "" "" "" "" "" "" "" "" "8965.2" "7850.1" "9009.9" "9861.5" "7944.5" "9521.1" "7418.9" "8475.4" "8786.0" "3656.4" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2495561624923528868" "False" "High" "IsMasterProtein" "Q10567" "AP-1 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP1B1 PE=1 SV=3" "0.000" "False" "203.266" "39" "33" "63" "15" "949" "104.5" "5.06" "272.54" "33" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "162" "ENSG00000100280" "AP1B1" "C9JRD1; F8WDL0; hsa:162; P78436; Q10567; Q20WL3; Q86X54" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "19" "1.036" "1.075" "0.996" "1.026" "1.008" "1.024" "1.012" "1.051" "1.101" "6708.0" "6946.5" "7212.6" "6680.0" "6879.8" "6758.9" "6871.3" "6786.7" "7052.9" "7382.9" "" "" "" "" "" "" "" "" "" "" "6031.2" "5620.8" "6524.0" "6520.6" "5677.3" "6758.9" "5145.0" "5994.4" "6310.9" "2635.5" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2706346813500612186" "False" "High" "IsMasterProtein" "Q9C0C9" "(E3-independent) E2 ubiquitin-conjugating enzyme OS=Homo sapiens OX=9606 GN=UBE2O PE=1 SV=3" "0.000" "False" "203.049" "38" "42" "89" "42" "1292" "141.2" "5.12" "320.07" "42" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "63893" "ENSG00000175931" "UBE2O" "A6NDU5; hsa:63893; Q69YP4; Q6PIZ2; Q86UA4; Q8N425; Q8TBN1; Q9BSW1; Q9C0C9; Q9H6E6; Q9H7E4; Q9H9B2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.987" "0.997" "0.999" "0.978" "0.986" "1.016" "0.953" "0.971" "1.113" "7321.3" "7224.7" "7301.3" "7315.3" "7158.5" "7219.4" "7436.0" "6977.6" "7106.4" "8145.0" "" "" "" "" "" "" "" "" "" "" "6582.5" "5846.0" "6604.3" "7140.7" "5907.3" "7219.4" "5567.9" "6163.1" "6358.8" "2907.5" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636491781207187808" "False" "High" "IsMasterProtein" "P14868" "Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=DARS1 PE=1 SV=2" "0.000" "False" "202.538" "75" "35" "90" "35" "501" "57.1" "6.55" "320.12" "35" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00152, Pf01336" "1615" "ENSG00000115866" "DARS1" "A8K3J2; D3DP77; hsa:1615; P14868; Q2TNI3; Q32Q69; Q53HV4; Q53YC5; Q68CR9; Q9BW52" "Alanine and aspartate metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.997" "1.036" "1.007" "0.977" "1.013" "1.004" "0.959" "1.013" "1.663" "8841.5" "8813.8" "9159.4" "8903.8" "8635.4" "8955.0" "8872.7" "8476.3" "8953.8" "14699.3" "" "" "" "" "" "" "" "" "" "" "7949.3" "7131.8" "8285.0" "8691.3" "7126.1" "8955.0" "6643.7" "7486.8" "8011.8" "5247.2" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6965600281876429507" "False" "High" "IsMasterProtein" "P46063" "ATP-dependent DNA helicase Q1 OS=Homo sapiens OX=9606 GN=RECQL PE=1 SV=3" "0.000" "False" "202.062" "54" "32" "96" "31" "649" "73.4" "7.88" "347.26" "32" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf16124" "5965" "ENSG00000004700" "RECQL" "A8K6G2; P46063" "Progeria-associated lipodystrophy" "" "1" "1" "1.005" "1.012" "0.986" "0.989" "1.039" "0.964" "0.979" "1.049" "0.798" "10912.5" "10972.5" "11038.9" "10759.3" "10795.0" "11340.0" "10517.0" "10684.6" "11442.3" "8712.3" "" "" "" "" "" "" "" "" "" "" "9811.4" "8878.5" "9985.0" "10502.6" "8908.2" "11340.0" "7874.8" "9437.3" "10238.5" "3110.0" "42" "42" "42" "42" "42" "42" "42" "42" "42" "42" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7978508680545557598" "False" "High" "IsMasterProtein" "Q1KMD3" "Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Homo sapiens OX=9606 GN=HNRNPUL2 PE=1 SV=1" "0.000" "False" "200.696" "47" "31" "85" "31" "747" "85.1" "4.91" "326.23" "31" "" "nucleus;other cell component" "" "Pf00622, Pf02037, Pf13671" "221092" "ENSG00000214753" "HNRNPUL2" "hsa:221092; Q1KMD3; Q8N3B3" "" "" "0" "0" "1.045" "1.071" "1.035" "1.004" "1.041" "1.004" "1.043" "1.050" "1.153" "7361.5" "7692.6" "7886.0" "7620.0" "7392.8" "7660.7" "7387.9" "7678.6" "7732.1" "8486.3" "" "" "" "" "" "" "" "" "" "" "6618.7" "6224.6" "7133.2" "7438.2" "6100.6" "7660.7" "5531.8" "6782.3" "6918.6" "3029.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4347150339173577721" "False" "High" "IsMasterProtein" "Q92878" "DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1" "0.000" "False" "199.988" "41" "56" "85" "56" "1312" "153.8" "6.89" "297.95" "56" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04423, Pf13476, Pf13558" "10111" "ENSG00000113522" "RAD50" "B9EGF5; hsa:10111; O43254; Q6GMT7; Q6P5X3; Q92878; Q9UP86" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; DNA damage response" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "1.070" "0.997" "0.984" "1.056" "1.010" "1.052" "1.043" "1.059" "1.095" "7296.1" "7809.7" "7271.4" "7177.0" "7706.2" "7370.1" "7676.5" "7612.9" "7729.6" "7991.8" "" "" "" "" "" "" "" "" "" "" "6559.9" "6319.3" "6577.2" "7005.8" "6359.3" "7370.1" "5747.9" "6724.2" "6916.4" "2852.9" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93919318191628628" "False" "High" "IsMasterProtein" "Q92499" "ATP-dependent RNA helicase DDX1 OS=Homo sapiens OX=9606 GN=DDX1 PE=1 SV=2" "0.000" "False" "199.773" "56" "36" "83" "36" "740" "82.4" "7.23" "310.74" "36" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00622" "1653" "ENSG00000079785" "DDX1" "B4DME8; B4DPN6; hsa:1653; Q92499" "DDX1 as a regulatory component of the Drosha microprocessor; mRNA processing" "tRNA processing in the nucleus" "3" "0" "1.038" "1.021" "1.032" "1.052" "1.051" "1.007" "1.024" "1.046" "0.891" "6425.8" "6672.5" "6562.9" "6629.8" "6757.9" "6753.5" "6468.3" "6582.4" "6719.7" "5722.8" "" "" "" "" "" "" "" "" "" "" "5777.4" "5399.1" "5936.3" "6471.6" "5576.8" "6753.5" "4843.3" "5814.0" "6012.7" "2042.9" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5089087001200962096" "False" "High" "IsMasterProtein" "Q12802" "A-kinase anchor protein 13 OS=Homo sapiens OX=9606 GN=AKAP13 PE=1 SV=2" "0.000" "False" "198.330" "22" "42" "63" "42" "2813" "307.4" "5.24" "257.20" "42" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf10522" "11214" "ENSG00000170776" "AKAP13" "hsa:11214; Q12802; Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; G protein signaling pathways" "RHOC GTPase cycle; RHOA GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOB GTPase cycle" "8" "0" "1.025" "0.937" "1.018" "1.045" "0.972" "1.059" "1.004" "0.989" "1.197" "4677.7" "4796.8" "4383.7" "4764.0" "4887.4" "4545.6" "4951.5" "4697.1" "4628.1" "5598.7" "" "" "" "" "" "" "" "" "" "" "4205.8" "3881.4" "3965.2" "4650.3" "4033.2" "4545.6" "3707.6" "4148.8" "4141.2" "1998.6" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6681537936157474887" "False" "High" "IsMasterProtein" "Q9UH65" "Switch-associated protein 70 OS=Homo sapiens OX=9606 GN=SWAP70 PE=1 SV=1" "0.000" "False" "198.164" "58" "36" "102" "35" "585" "69.0" "5.87" "376.78" "36" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00169" "23075" "ENSG00000133789" "SWAP70" "D3DQV1; hsa:23075; O75135; Q7LCY6; Q9P061; Q9P0Z8; Q9UH65" "" "RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle" "3" "1" "0.978" "0.948" "0.987" "0.980" "0.930" "0.985" "1.009" "0.946" "0.859" "11627.3" "11369.2" "11027.6" "11475.9" "11392.7" "10814.0" "11449.8" "11728.0" "10998.1" "9986.9" "" "" "" "" "" "" "" "" "" "" "10454.1" "9199.5" "9974.9" "11202.1" "9401.5" "10814.0" "8573.4" "10359.0" "9841.1" "3565.1" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2651873567954206530" "False" "High" "IsMasterProtein" "Q9P2J5" "Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=LARS1 PE=1 SV=2" "0.000" "False" "198.088" "39" "40" "76" "40" "1176" "134.4" "7.30" "288.87" "40" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00133, Pf08264" "51520" "ENSG00000133706" "LARS1" "A2RRR4; A7E266; B4DJ10; hsa:51520; Q2TU79; Q9NSE1; Q9P2J5" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.018" "0.984" "1.026" "0.963" "0.980" "1.020" "0.963" "1.032" "2.277" "8135.5" "8278.7" "8001.3" "8346.9" "7830.5" "7970.7" "8300.6" "7835.8" "8398.7" "18523.7" "" "" "" "" "" "" "" "" "" "" "7314.6" "6698.9" "7237.4" "8147.8" "6461.8" "7970.7" "6215.3" "6921.1" "7515.1" "6612.4" "41" "41" "41" "41" "41" "41" "41" "41" "41" "41" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1343514979661683430" "False" "High" "IsMasterProtein" "P22234" "Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase OS=Homo sapiens OX=9606 GN=PAICS PE=1 SV=3" "0.000" "False" "196.391" "58" "30" "120" "30" "425" "47.0" "7.23" "479.58" "30" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00731, Pf01259" "10606" "ENSG00000128050" "PAICS" "E9PDH9; hsa:10606; P22234; Q68CQ5" "Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "2" "0" "1.071" "1.032" "1.049" "1.028" "1.067" "1.045" "1.055" "1.041" "0.745" "10387.6" "11128.2" "10716.0" "10897.6" "10676.3" "11081.7" "10856.6" "10960.3" "10817.9" "7740.3" "" "" "" "" "" "" "" "" "" "" "9339.5" "9004.6" "9692.9" "10637.5" "8810.3" "11081.7" "8129.2" "9680.9" "9679.8" "2763.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4113768837461094803" "False" "High" "IsMasterProtein" "A0AVT1" "Ubiquitin-like modifier-activating enzyme 6 OS=Homo sapiens OX=9606 GN=UBA6 PE=1 SV=1" "0.000" "False" "196.253" "45" "39" "73" "39" "1052" "117.9" "6.14" "267.98" "39" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00899, Pf09358, Pf10585, Pf16190, Pf16191" "55236" "ENSG00000033178" "UBA6" "A0AVT1; A6N8M7; B2RAV3; hsa:55236; Q4W5K0; Q6UV21; Q86T78; Q86TC7; Q8N5T3; Q8N9E4; Q9H3T7; Q9NVC9" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.000" "0.958" "0.998" "0.994" "0.943" "1.021" "0.983" "0.943" "0.958" "7307.6" "7307.5" "7000.7" "7294.6" "7262.5" "6893.2" "7458.5" "7182.6" "6888.9" "6997.5" "" "" "" "" "" "" "" "" "" "" "6570.2" "5913.0" "6332.4" "7120.5" "5993.1" "6893.2" "5584.7" "6344.1" "6164.1" "2497.9" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6444296704773161539" "False" "High" "IsMasterProtein" "Q9NSD9" "Phenylalanine--tRNA ligase beta subunit OS=Homo sapiens OX=9606 GN=FARSB PE=1 SV=3" "0.000" "False" "194.887" "58" "32" "94" "32" "589" "66.1" "6.84" "364.27" "32" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03483, Pf03484, Pf17759, Pf18262" "10056" "ENSG00000116120" "FARSB" "B4DFM0; hsa:10056; O95708; Q4ZFX1; Q57ZJ5; Q9NSD9; Q9NZZ6" "VEGFA-VEGFR2 signaling; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "1.035" "1.007" "1.018" "1.006" "0.994" "1.032" "0.997" "1.014" "0.930" "8125.9" "8410.5" "8183.3" "8270.3" "8178.5" "8078.0" "8382.5" "8101.4" "8236.4" "7556.3" "" "" "" "" "" "" "" "" "" "" "7305.9" "6805.5" "7402.0" "8073.0" "6749.0" "8078.0" "6276.6" "7155.7" "7369.8" "2697.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588526575422441763" "False" "High" "IsMasterProtein" "P42285" "Exosome RNA helicase MTR4 OS=Homo sapiens OX=9606 GN=MTREX PE=1 SV=3" "0.000" "False" "194.859" "42" "38" "69" "38" "1042" "117.7" "6.52" "269.77" "38" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf21408" "23517" "ENSG00000039123" "MTREX" "hsa:23517; P42285; Q2M386; Q6MZZ8; Q6P170; Q8N5R0; Q8TAG2" "" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.026" "1.009" "0.960" "1.038" "0.963" "1.005" "0.961" "0.998" "0.773" "7648.5" "7844.1" "7717.7" "7339.3" "7942.6" "7363.1" "7685.5" "7348.4" "7634.7" "5911.8" "" "" "" "" "" "" "" "" "" "" "6876.8" "6347.2" "6980.9" "7164.2" "6554.4" "7363.1" "5754.7" "6490.5" "6831.5" "2110.4" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770447616449315305" "False" "High" "IsMasterProtein" "Q9Y678" "Coatomer subunit gamma-1 OS=Homo sapiens OX=9606 GN=COPG1 PE=1 SV=1" "0.000" "False" "194.624" "47" "34" "76" "31" "874" "97.7" "5.47" "280.12" "34" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf01602, Pf08752, Pf16381" "22820" "ENSG00000181789" "COPG1" "A8K6M8; B3KMF6; hsa:22820; Q54AC4; Q9Y678" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "3" "0.995" "1.011" "0.957" "1.034" "1.028" "0.972" "1.001" "1.023" "0.858" "6090.9" "6057.4" "6159.0" "5828.1" "6298.4" "6262.2" "5918.9" "6094.9" "6231.7" "5226.6" "" "" "" "" "" "" "" "" "" "" "5476.3" "4901.5" "5571.0" "5689.0" "5197.6" "6262.2" "4432.0" "5383.4" "5576.1" "1865.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936589147855356359" "False" "High" "IsMasterProtein" "P54886" "Delta-1-pyrroline-5-carboxylate synthase OS=Homo sapiens OX=9606 GN=ALDH18A1 PE=1 SV=2" "0.000" "False" "194.464" "52" "35" "83" "35" "795" "87.2" "7.12" "306.33" "35" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf00171, Pf00696" "5832" "ENSG00000059573" "ALDH18A1" "B2R5Q4; B7Z350; B7Z5X8; B7ZLP1; D3DR44; hsa:5832; O95952; P54886; Q3KQU2; Q5T566; Q5T567; Q9UM72" "Amino acid metabolism" "Mitochondrial protein degradation" "2" "0" "1.059" "1.025" "0.976" "1.056" "1.006" "1.052" "1.012" "1.031" "0.795" "6663.5" "7053.4" "6826.9" "6506.1" "7038.5" "6703.5" "7007.2" "6742.7" "6871.4" "5296.2" "" "" "" "" "" "" "" "" "" "" "5991.1" "5707.3" "6175.1" "6350.9" "5808.3" "6703.5" "5246.8" "5955.6" "6148.5" "1890.6" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8428260618384848940" "False" "High" "IsMasterProtein" "Q15029" "116 kDa U5 small nuclear ribonucleoprotein component OS=Homo sapiens OX=9606 GN=EFTUD2 PE=1 SV=1" "0.000" "False" "193.994" "47" "39" "78" "38" "972" "109.4" "5.00" "295.16" "39" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492, Pf16004" "9343" "ENSG00000108883" "EFTUD2" "B4DK30; B4DMC0; D3DX58; hsa:9343; K7EJ81; Q15029; Q9BUR0" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "0.972" "1.023" "0.923" "0.980" "1.049" "0.941" "0.929" "0.989" "0.769" "5401.6" "5251.2" "5523.7" "4984.0" "5293.9" "5664.8" "5083.9" "5020.3" "5342.4" "4153.8" "" "" "" "" "" "" "" "" "" "" "4856.5" "4249.1" "4996.3" "4865.1" "4368.6" "5664.8" "3806.7" "4434.2" "4780.3" "1482.8" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "964900113043376779" "False" "High" "IsMasterProtein" "Q9Y265" "RuvB-like 1 OS=Homo sapiens OX=9606 GN=RUVBL1 PE=1 SV=1" "0.000" "False" "193.981" "64" "23" "79" "23" "456" "50.2" "6.42" "314.40" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06068, Pf17856" "8607" "ENSG00000175792" "RUVBL1" "B2R5S0; hsa:8607; P82276; Q1KMR0; Q53HK5; Q53HL7; Q53Y27; Q9BSX9; Q9Y265" "Gastric cancer network 1; lncRNA in canonical Wnt signaling and colorectal cancer" "Formation of the beta-catenin:TCF transactivating complex; UCH proteinases; Ub-specific processing proteases; Deposition of new CENPA-containing nucleosomes at the centromere; Telomere Extension By Telomerase; HATs acetylate histones; DNA Damage Recognition in GG-NER" "9" "0" "1.026" "0.994" "1.001" "1.003" "0.986" "0.998" "1.016" "1.028" "1.078" "7800.1" "8000.3" "7751.3" "7810.1" "7819.9" "7688.8" "7784.8" "7925.6" "8021.9" "8411.6" "" "" "" "" "" "" "" "" "" "" "7013.1" "6473.6" "7011.3" "7623.7" "6453.1" "7688.8" "5829.0" "7000.4" "7177.9" "3002.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4081821255654730279" "False" "High" "IsMasterProtein" "Q13618" "Cullin-3 OS=Homo sapiens OX=9606 GN=CUL3 PE=1 SV=2" "0.000" "False" "193.494" "43" "32" "72" "32" "768" "88.9" "8.48" "280.59" "32" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00888, Pf10557" "8452" "ENSG00000036257" "CUL3" "A8K536; B8ZZC3; hsa:8452; O75415; Q13618; Q569L3; Q9UBI8; Q9UET7" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Hedgehog signaling pathway; NRF2-ARE regulation; 22q11.2 copy number variation syndrome; Head and neck squamous cell carcinoma; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Degradation of DVL; Hedgehog 'on' state; Regulation of RAS by GAPs; Neddylation; KEAP1-NFE2L2 pathway; RHOBTB3 ATPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "16" "0" "1.035" "1.002" "0.996" "1.027" "0.956" "1.003" "1.015" "1.011" "0.798" "6619.0" "6853.6" "6635.0" "6591.6" "6800.5" "6328.3" "6639.2" "6718.9" "6692.2" "5282.3" "" "" "" "" "" "" "" "" "" "" "5951.1" "5545.7" "6001.5" "6434.3" "5611.9" "6328.3" "4971.3" "5934.6" "5988.1" "1885.6" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952006714438079555" "False" "High" "IsMasterProtein" "Q9Y4L1" "Hypoxia up-regulated protein 1 OS=Homo sapiens OX=9606 GN=HYOU1 PE=1 SV=1" "0.000" "False" "193.291" "47" "37" "69" "37" "999" "111.3" "5.22" "274.36" "37" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "other molecular function" "Pf00012" "10525" "ENSG00000149428; ENSG00000280682" "HYOU1" "A8C1Z0; B7Z909; hsa:10525; Q2I204; Q53H25; Q9Y4L1" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Scavenging by Class F Receptors" "3" "0" "1.018" "1.103" "1.002" "1.051" "1.097" "1.104" "1.076" "1.116" "1.126" "4870.7" "4959.4" "5374.7" "4882.5" "5120.5" "5342.6" "5377.6" "5240.6" "5437.4" "5482.4" "" "" "" "" "" "" "" "" "" "" "4379.2" "4013.0" "4861.6" "4766.0" "4225.5" "5342.6" "4026.6" "4628.8" "4865.4" "1957.1" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7738217365816998519" "False" "High" "IsMasterProtein" "P41250" "Glycine--tRNA ligase OS=Homo sapiens OX=9606 GN=GARS1 PE=1 SV=3" "0.000" "False" "193.258" "44" "26" "94" "26" "739" "83.1" "7.03" "351.30" "26" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "non-structural extracellular;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00458, Pf00587, Pf03129" "2617" "ENSG00000106105" "GARS1" "A0A090N8G0; B3KQA2; B4DIA0; hsa:2617; P41250; Q969Y1" "HDAC6 interactions in the central nervous system" "Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "0.995" "1.009" "0.967" "0.996" "0.941" "0.986" "0.979" "0.967" "0.824" "7149.2" "7111.6" "7216.1" "6915.2" "7119.2" "6728.1" "7045.7" "7000.1" "6915.9" "5894.0" "" "" "" "" "" "" "" "" "" "" "6427.8" "5754.5" "6527.2" "6750.2" "5874.9" "6728.1" "5275.6" "6182.9" "6188.3" "2104.0" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "454806171855366482" "False" "High" "IsMasterProtein" "P40939" "Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=HADHA PE=1 SV=2" "0.000" "False" "193.110" "50" "31" "70" "31" "763" "82.9" "9.04" "279.16" "31" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00378, Pf00725, Pf02737" "3030" "ENSG00000084754" "HADHA" "B2R7L4; B4DYP2; hsa:3030; P40939; Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Valproic acid pathway; Mitochondrial fatty acid oxidation disorders; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "13" "0" "0.971" "0.964" "0.960" "0.925" "0.909" "0.973" "0.936" "0.956" "0.884" "6533.6" "6341.6" "6300.0" "6271.7" "6044.6" "5938.0" "6357.5" "6113.5" "6247.6" "5773.8" "" "" "" "" "" "" "" "" "" "" "5874.4" "5131.4" "5698.6" "6122.1" "4988.1" "5938.0" "4760.3" "5399.9" "5590.3" "2061.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4630001761870027344" "False" "High" "IsMasterProtein" "P34897" "Serine hydroxymethyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=SHMT2 PE=1 SV=3" "0.000" "False" "192.773" "60" "25" "146" "24" "504" "56.0" "8.53" "531.32" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6472" "ENSG00000182199" "SHMT2" "B7Z9F1; E7EQ19; E7EU43; hsa:6472; O00740; P34897; Q8N1A5" "Glycine metabolism; Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Metabolic Epileptic Disorders" "RHOG GTPase cycle; Mitochondrial protein degradation; Metabolism of folate and pterines" "13" "2" "1.007" "1.032" "1.020" "1.024" "0.994" "1.002" "1.012" "1.031" "0.790" "8379.6" "8441.6" "8650.0" "8543.2" "8581.8" "8326.8" "8400.5" "8480.0" "8636.6" "6621.9" "" "" "" "" "" "" "" "" "" "" "7534.1" "6830.6" "7824.2" "8339.3" "7081.8" "8326.8" "6290.1" "7490.0" "7727.9" "2363.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5794386193398091018" "False" "High" "IsMasterProtein" "Q9NY33" "Dipeptidyl peptidase 3 OS=Homo sapiens OX=9606 GN=DPP3 PE=1 SV=2" "0.000" "False" "192.639" "54" "31" "70" "31" "737" "82.5" "5.10" "296.31" "31" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03571" "10072" "ENSG00000254986" "DPP3" "B2RDB5; B4DLX4; F5H8L6; hsa:10072; O95748; Q969H2; Q9BV67; Q9HAL6; Q9NY33" "" "Neddylation; KEAP1-NFE2L2 pathway" "2" "0" "1.007" "0.993" "1.035" "1.003" "0.951" "1.026" "0.971" "0.978" "0.935" "5300.7" "5340.4" "5264.0" "5486.0" "5316.0" "5041.2" "5438.2" "5147.3" "5183.3" "4957.7" "" "" "" "" "" "" "" "" "" "" "4765.8" "4321.2" "4761.5" "5355.1" "4386.9" "5041.2" "4072.0" "4546.4" "4638.0" "1769.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877327812570757942" "False" "High" "IsMasterProtein" "P50570" "Dynamin-2 OS=Homo sapiens OX=9606 GN=DNM2 PE=1 SV=2" "0.000" "False" "192.177" "49" "36" "80" "27" "870" "98.0" "7.44" "301.86" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "1785" "ENSG00000079805" "DNM2" "A8K1B6; E7EV30; E9PEQ4; hsa:1785; K7ESI9; P50570; Q5I0Y0; Q7Z5S3; Q9UPH4" "Synaptic vesicle pathway; Fragile X syndrome; Intracellular trafficking proteins involved in CMT neuropathy" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Recycling pathway of L1; NGF-stimulated transcription; Toll Like Receptor 4 (TLR4) Cascade; NOSTRIN mediated eNOS trafficking; Retrograde neurotrophin signalling; Formation of annular gap junctions" "14" "11" "1.010" "0.983" "0.993" "1.003" "0.955" "1.010" "0.988" "1.008" "0.956" "6697.4" "6767.0" "6583.5" "6649.7" "6715.3" "6392.8" "6764.8" "6619.8" "6754.3" "6400.9" "" "" "" "" "" "" "" "" "" "" "6021.6" "5475.6" "5955.0" "6491.0" "5541.6" "6392.8" "5065.3" "5847.0" "6043.7" "2284.9" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6400995593712089390" "False" "High" "IsMasterProtein" "Q9NYU2" "UDP-glucose:glycoprotein glucosyltransferase 1 OS=Homo sapiens OX=9606 GN=UGGT1 PE=1 SV=3" "0.000" "False" "192.176" "32" "39" "66" "39" "1555" "177.1" "5.63" "268.37" "39" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf06427, Pf18400, Pf18401, Pf18402, Pf18403, Pf18404" "56886" "ENSG00000136731" "UGGT1" "hsa:56886; Q53QP2; Q53SL3; Q8IW30; Q9H8I4; Q9NYU2" "IL-18 signaling pathway" "ER Quality Control Compartment (ERQC)" "2" "0" "1.015" "1.006" "0.974" "1.041" "1.008" "1.001" "1.009" "1.036" "0.873" "5417.7" "5501.2" "5449.4" "5276.7" "5640.0" "5460.0" "5425.8" "5463.9" "5611.8" "4731.7" "" "" "" "" "" "" "" "" "" "" "4871.1" "4451.4" "4929.1" "5150.8" "4654.2" "5460.0" "4062.7" "4826.1" "5021.4" "1689.1" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260804329009372873" "False" "High" "IsMasterProtein" "Q13045" "Protein flightless-1 homolog OS=Homo sapiens OX=9606 GN=FLII PE=1 SV=2" "0.000" "False" "189.693" "37" "38" "71" "38" "1269" "144.7" "6.05" "269.59" "38" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00560, Pf00626, Pf12799, Pf13855" "2314" "ENSG00000177731; ENSG00000284571" "FLII" "B4DIL0; F5H407; hsa:2314; J3QLG3; Q13045" "VEGFA-VEGFR2 signaling; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.035" "1.036" "0.975" "1.004" "0.985" "1.014" "0.969" "1.039" "1.139" "5525.5" "5720.6" "5725.5" "5389.9" "5547.3" "5440.4" "5600.3" "5356.3" "5741.9" "6290.9" "" "" "" "" "" "" "" "" "" "" "4967.9" "4628.9" "5178.9" "5261.3" "4577.8" "5440.4" "4193.4" "4731.0" "5137.8" "2245.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1146438711958021826" "False" "High" "IsMasterProtein" "Q16851" "UTP--glucose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=UGP2 PE=1 SV=5" "0.000" "False" "189.358" "61" "28" "90" "28" "508" "56.9" "8.15" "341.93" "28" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf01704" "7360" "ENSG00000169764" "UGP2" "hsa:7360; Q07131; Q0P6K2; Q16851; Q86Y81; Q9BU15" "Exercise-induced circadian regulation; Glycogen synthesis and degradation; Glucuronidation" "Glycogen synthesis; Formation of the active cofactor, UDP-glucuronate" "5" "0" "0.994" "0.994" "0.970" "0.997" "0.964" "0.964" "0.987" "0.971" "0.773" "9336.6" "9282.7" "9283.1" "9058.8" "9306.2" "8997.2" "9003.6" "9217.4" "9066.1" "7219.3" "" "" "" "" "" "" "" "" "" "" "8394.5" "7511.3" "8396.9" "8842.7" "7679.7" "8997.2" "6741.7" "8141.4" "8112.3" "2577.1" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573654140983497752" "False" "High" "IsMasterProtein" "P12004" "Proliferating cell nuclear antigen OS=Homo sapiens OX=9606 GN=PCNA PE=1 SV=1" "0.000" "False" "188.441" "78" "20" "126" "20" "261" "28.8" "4.69" "501.81" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00705, Pf02747" "5111" "ENSG00000132646" "PCNA" "B2R897; D3DW02; hsa:5111; P12004" "Cell cycle; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Oxidative damage response; EGF/EGFR signaling pathway; G1 to S cell cycle control; DNA replication; Hepatitis B infection; Base excision repair; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; Urotensin-II-mediated signaling pathway; DNA mismatch repair; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; NF1 copy number variation syndrome ; Rubinstein-Taybi syndrome 1" "E3 ubiquitin ligases ubiquitinate target proteins; SUMOylation of DNA replication proteins; Termination of translesion DNA synthesis; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; G1/S-Specific Transcription; Recognition of DNA damage by PCNA-containing replication complex; Transcription of E2F targets under negative control by DREAM complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "47" "0" "1.034" "1.064" "1.036" "1.019" "1.057" "1.043" "1.022" "1.106" "0.801" "11536.2" "11926.6" "12275.8" "11956.9" "11756.0" "12196.3" "12028.8" "11792.1" "12753.9" "9244.1" "" "" "" "" "" "" "" "" "" "" "10372.2" "9650.6" "11103.9" "11671.6" "9701.2" "12196.3" "9006.8" "10415.6" "11412.1" "3299.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982542769367786087" "False" "High" "IsMasterProtein" "O75116" "Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4" "0.000" "False" "188.227" "34" "47" "64" "40" "1388" "160.8" "6.02" "226.85" "47" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08912" "9475" "ENSG00000134318" "ROCK2" "hsa:9475; O75116; Q53QZ0; Q53SJ7; Q9UQN5" "Androgen receptor signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Leptin signaling pathway; Pathogenic Escherichia coli infection; Spinal cord injury; Focal adhesion; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling; Airway smooth muscle cell contraction; Regulation of actin cytoskeleton; GDNF signaling; G13 signaling pathway" "Potential therapeutics for SARS; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHOB GTPase cycle; EPHB-mediated forward signaling; VEGFA-VEGFR2 Pathway; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHOBTB1 GTPase cycle; RHOH GTPase cycle" "27" "0" "1.000" "1.011" "0.982" "1.020" "0.967" "1.038" "1.028" "0.983" "1.013" "5670.6" "5669.5" "5730.7" "5570.1" "5782.8" "5485.1" "5888.4" "5827.0" "5572.4" "5744.2" "" "" "" "" "" "" "" "" "" "" "5098.4" "4587.6" "5183.6" "5437.1" "4772.0" "5485.1" "4409.1" "5146.8" "4986.1" "2050.5" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1547781430018805415" "False" "High" "IsMasterProtein" "P30101" "Protein disulfide-isomerase A3 OS=Homo sapiens OX=9606 GN=PDIA3 PE=1 SV=4" "0.000" "False" "188.164" "60" "28" "110" "27" "505" "56.7" "6.35" "427.99" "28" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00085, Pf13848" "2923" "ENSG00000167004" "PDIA3" "hsa:2923; P30101; Q13453; Q14255; Q8IYF8; Q9UMU7" "Prion disease pathway" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Calnexin/calreticulin cycle" "4" "0" "0.926" "0.958" "1.028" "0.926" "0.939" "0.969" "0.964" "0.932" "1.116" "10518.3" "9736.8" "10075.5" "10809.6" "9739.4" "9877.2" "10187.2" "10142.3" "9805.4" "11743.0" "" "" "" "" "" "" "" "" "" "" "9457.0" "7878.7" "9113.6" "10551.7" "8037.1" "9877.2" "7627.9" "8958.3" "8773.8" "4191.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618262664170988145" "False" "High" "IsMasterProtein" "P61978" "Heterogeneous nuclear ribonucleoprotein K OS=Homo sapiens OX=9606 GN=HNRNPK PE=1 SV=1" "0.000" "False" "187.914" "56" "26" "212" "26" "463" "50.9" "5.54" "654.74" "26" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf08067" "3190" "ENSG00000165119" "HNRNPK" "hsa:3190; P61978; Q07244; Q15671; Q59F98; Q5T6W4; Q60577; Q6IBN1; Q922Y7; Q96J62" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; HCMV Late Events; SUMOylation of RNA binding proteins; Processing of Capped Intron-Containing Pre-mRNA" "6" "0" "0.988" "0.995" "1.008" "1.022" "0.990" "1.029" "1.020" "1.004" "1.013" "16499.2" "16309.0" "16415.5" "16639.4" "16858.5" "16328.9" "16980.2" "16834.9" "16564.2" "16720.2" "" "" "" "" "" "" "" "" "" "" "14834.4" "13196.6" "14848.4" "16242.3" "13911.9" "16328.9" "12714.4" "14869.7" "14821.5" "5968.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1718244645714628913" "False" "High" "IsMasterProtein" "Q9UIA9" "Exportin-7 OS=Homo sapiens OX=9606 GN=XPO7 PE=1 SV=3" "0.000" "False" "187.111" "40" "37" "70" "37" "1087" "123.8" "6.32" "258.82" "37" "transport" "nucleus;other cell component" "other molecular function" "Pf03810" "23039" "ENSG00000130227" "XPO7" "hsa:23039; O94846; Q6PJK9; Q8NEK7; Q9UIA9" "" "" "0" "0" "1.006" "0.999" "0.920" "1.024" "0.967" "1.017" "0.968" "0.986" "0.799" "5030.6" "5059.4" "5026.1" "4628.3" "5152.2" "4867.1" "5115.0" "4868.4" "4961.9" "4018.9" "" "" "" "" "" "" "" "" "" "" "4523.0" "4093.9" "4546.3" "4517.8" "4251.7" "4867.1" "3829.9" "4300.1" "4439.9" "1434.6" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6978617919950458725" "False" "High" "IsMasterProtein" "O43592" "Exportin-T OS=Homo sapiens OX=9606 GN=XPOT PE=1 SV=2" "0.000" "False" "186.680" "36" "28" "80" "28" "962" "109.9" "5.39" "275.03" "28" "transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19282" "11260" "ENSG00000184575" "XPOT" "A6NLH1; hsa:11260; O43592; O43784; Q8WUG2; Q9BVS7" "" "tRNA processing in the nucleus" "1" "0" "1.026" "0.989" "0.908" "1.025" "0.921" "1.001" "0.962" "0.962" "0.998" "6663.9" "6837.9" "6590.8" "6053.6" "6828.6" "6138.4" "6670.0" "6411.1" "6409.1" "6653.7" "" "" "" "" "" "" "" "" "" "" "5991.5" "5533.0" "5961.6" "5909.2" "5635.1" "6138.4" "4994.3" "5662.7" "5734.8" "2375.2" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-797188196996991140" "False" "High" "IsMasterProtein" "P15170" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens OX=9606 GN=GSPT1 PE=1 SV=1" "0.000" "False" "186.438" "51" "26" "81" "12" "499" "55.7" "5.62" "289.86" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "2935" "ENSG00000103342" "GSPT1" "hsa:2935; J3KQG6; P15170; Q96GF2" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "4" "18" "1.033" "1.020" "1.008" "0.998" "0.981" "1.020" "1.005" "1.017" "0.806" "7944.4" "8203.9" "8099.4" "8010.3" "7931.6" "7794.6" "8102.7" "7980.3" "8078.1" "6404.1" "" "" "" "" "" "" "" "" "" "" "7142.8" "6638.3" "7326.2" "7819.1" "6545.3" "7794.6" "6067.1" "7048.7" "7228.2" "2286.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-515522588376759980" "False" "High" "IsMasterProtein" "O60506" "Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens OX=9606 GN=SYNCRIP PE=1 SV=2" "0.000" "False" "186.147" "52" "29" "96" "20" "623" "69.6" "8.59" "373.61" "29" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10492" "ENSG00000135316" "SYNCRIP" "E1P501; E1P502; hsa:10492; O60506; Q53H05; Q5TCG2; Q5TCG3; Q8IW78; Q8N599; Q96LC1; Q96LC2; Q9Y583" "" "" "0" "9" "0.995" "0.983" "0.961" "0.966" "1.016" "0.950" "0.962" "0.946" "0.873" "10173.5" "10120.3" "10003.0" "9781.6" "9824.5" "10338.1" "9665.0" "9785.0" "9624.1" "8879.9" "" "" "" "" "" "" "" "" "" "" "9146.9" "8189.0" "9048.0" "9548.2" "8107.4" "10338.1" "7236.9" "8642.8" "8611.6" "3169.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1156142612126302656" "False" "High" "IsMasterProtein" "P07814" "Bifunctional glutamate/proline--tRNA ligase OS=Homo sapiens OX=9606 GN=EPRS1 PE=1 SV=5" "0.000" "False" "186.089" "30" "39" "68" "38" "1512" "170.5" "7.33" "257.32" "39" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf00587, Pf00749, Pf03129, Pf03950, Pf09180, Pf20974" "2058" "ENSG00000136628" "EPRS1" "A0AVA9; B9EGH3; hsa:2058; P07814; Q05BP6; Q05DF8; Q5DSM1; Q5H9S5; Q6PD57; Q86X73" "Parkinson's disease pathway; VEGFA-VEGFR2 signaling; Amino acid metabolism" "tRNA modification in the nucleus and cytosol; Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "6" "1" "1.011" "0.992" "0.990" "0.932" "0.959" "1.006" "0.901" "1.035" "3.541" "6148.8" "6215.8" "6098.5" "6085.5" "5732.1" "5895.4" "6185.2" "5540.4" "6364.5" "21770.0" "" "" "" "" "" "" "" "" "" "" "5528.4" "5029.6" "5516.3" "5940.3" "4730.2" "5895.4" "4631.4" "4893.6" "5694.9" "7771.3" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7233412111740596343" "False" "High" "IsMasterProtein" "P19367" "Hexokinase-1 OS=Homo sapiens OX=9606 GN=HK1 PE=1 SV=3" "0.000" "False" "186.080" "41" "35" "65" "32" "917" "102.4" "6.80" "235.91" "35" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00349, Pf03727" "3098" "ENSG00000156515" "HK1" "E9PCK0; hsa:3098; O43443; O43444; O75574; P19367; Q5VTC3; Q96HC8; Q9NNZ4; Q9NNZ5" "Cori cycle; Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glucose metabolism in triple-negative breast cancer cells; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Glycolysis; Defective HK1 causes hexokinase deficiency (HK deficiency)" "12" "3" "1.049" "0.981" "0.957" "1.028" "0.982" "0.989" "0.985" "1.012" "0.757" "6039.7" "6337.6" "5922.5" "5781.1" "6205.9" "5928.6" "5971.7" "5946.9" "6112.4" "4569.5" "" "" "" "" "" "" "" "" "" "" "5430.3" "5128.2" "5357.1" "5643.2" "5121.2" "5928.6" "4471.5" "5252.7" "5469.4" "1631.2" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8623682461858759698" "False" "High" "IsMasterProtein" "P54578" "Ubiquitin carboxyl-terminal hydrolase 14 OS=Homo sapiens OX=9606 GN=USP14 PE=1 SV=3" "0.000" "False" "185.495" "58" "26" "98" "26" "494" "56.0" "5.30" "374.36" "26" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00443" "9097" "ENSG00000101557" "USP14" "B7Z4N8; hsa:9097; J3QRZ5; P54578; Q53XY5" "" "Ub-specific processing proteases; Regulation of NF-kappa B signaling" "2" "0" "1.013" "1.023" "1.012" "1.007" "1.044" "1.001" "1.013" "1.018" "0.817" "7476.0" "7575.3" "7645.1" "7564.1" "7525.8" "7805.5" "7480.9" "7574.6" "7607.6" "6104.4" "" "" "" "" "" "" "" "" "" "" "6721.7" "6129.6" "6915.2" "7383.6" "6210.5" "7805.5" "5601.5" "6690.3" "6807.3" "2179.1" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917642798524543660" "False" "High" "IsMasterProtein" "P52566" "Rho GDP-dissociation inhibitor 2 OS=Homo sapiens OX=9606 GN=ARHGDIB PE=1 SV=3" "0.000" "False" "185.292" "83" "20" "138" "20" "201" "23.0" "5.21" "557.76" "20" "signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf02115" "397" "ENSG00000111348" "ARHGDIB" "B5BU79; hsa:397; P52566" "Fas ligand pathway and stress induction of heat shock proteins; Vasopressin-regulated water reabsorption; G13 signaling pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle" "9" "0" "0.963" "0.947" "1.151" "0.899" "1.008" "0.937" "1.000" "0.918" "0.859" "17894.3" "17235.2" "16945.4" "20601.8" "16086.2" "18037.6" "16760.3" "17896.2" "16432.3" "15377.4" "" "" "" "" "" "" "" "" "" "" "16088.7" "13946.1" "15327.7" "20110.3" "13274.6" "18037.6" "12549.7" "15807.1" "14703.5" "5489.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7970699774180839953" "False" "High" "IsMasterProtein" "Q9Y230" "RuvB-like 2 OS=Homo sapiens OX=9606 GN=RUVBL2 PE=1 SV=3" "0.000" "False" "185.133" "62" "24" "86" "24" "463" "51.1" "5.64" "308.95" "24" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06068, Pf17856" "10856" "ENSG00000183207" "RUVBL2" "B3KQ59; E7ETE5; hsa:10856; Q6FIB9; Q6PK27; Q9Y230; Q9Y361" "" "HATs acetylate histones; Telomere Extension By Telomerase" "2" "0" "1.012" "1.003" "0.961" "1.034" "0.997" "1.011" "0.962" "1.023" "1.094" "6706.6" "6788.1" "6726.1" "6443.4" "6935.6" "6686.3" "6778.6" "6451.6" "6858.1" "7334.7" "" "" "" "" "" "" "" "" "" "" "6029.9" "5492.7" "6084.0" "6289.7" "5723.4" "6686.3" "5075.6" "5698.5" "6136.6" "2618.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5070657134179306573" "False" "High" "IsMasterProtein" "P55160" "Nck-associated protein 1-like OS=Homo sapiens OX=9606 GN=NCKAP1L PE=1 SV=3" "0.000" "False" "184.905" "31" "33" "77" "32" "1127" "128.1" "6.86" "293.39" "33" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf09735" "3071" "ENSG00000123338" "NCKAP1L" "B4DUT5; hsa:3071; P55160; Q52LW0" "Hematopoietic stem cell differentiation; Microglia pathogen phagocytosis pathway; TYROBP causal network in microglia" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Neutrophil degranulation; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "11" "0" "1.022" "1.005" "0.948" "1.029" "0.917" "1.002" "0.978" "0.991" "0.861" "6484.4" "6630.0" "6516.3" "6144.5" "6674.5" "5947.4" "6497.2" "6339.5" "6428.4" "5581.4" "" "" "" "" "" "" "" "" "" "" "5830.1" "5364.8" "5894.2" "5997.9" "5507.9" "5947.4" "4864.9" "5599.5" "5752.1" "1992.4" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2868702294912813046" "False" "High" "IsMasterProtein" "P60174" "Triosephosphate isomerase OS=Homo sapiens OX=9606 GN=TPI1 PE=1 SV=4" "0.000" "False" "184.793" "91" "21" "296" "21" "249" "26.7" "6.90" "1200.12" "21" "other metabolic processes" "cytosol" "other molecular function" "Pf00121" "7167" "ENSG00000111669" "TPI1" "B7Z5D8; D3DUS9; hsa:7167; P00938; P60174; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5" "Fatty acid beta-oxidation; Cori cycle; HIF1A and PPARG regulation of glycolysis; Clear cell renal cell carcinoma pathways; Aerobic glycolysis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "10" "0" "0.982" "0.985" "1.039" "1.004" "0.978" "0.978" "1.000" "0.985" "0.783" "24461.2" "24032.2" "24099.3" "25421.8" "24550.3" "23916.6" "23921.3" "24460.3" "24091.0" "19164.1" "" "" "" "" "" "" "" "" "" "" "21993.0" "19446.0" "21798.6" "24815.2" "20259.3" "23916.6" "17911.7" "21604.9" "21556.5" "6841.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964707792463719030" "False" "High" "IsMasterProtein" "O43776" "Asparagine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=NARS1 PE=1 SV=1" "0.000" "False" "184.580" "50" "28" "82" "28" "548" "62.9" "6.25" "334.48" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf20917" "4677" "ENSG00000134440" "NARS1" "B4DG16; hsa:4677; O43776; Q53GU6" "Photodynamic therapy-induced unfolded protein response" "Cytosolic tRNA aminoacylation" "2" "0" "1.024" "1.008" "1.005" "1.029" "0.960" "0.964" "1.002" "1.023" "0.794" "7016.6" "7187.8" "7075.1" "7051.6" "7220.3" "6738.5" "6765.5" "7028.3" "7177.6" "5570.5" "" "" "" "" "" "" "" "" "" "" "6308.6" "5816.1" "6399.6" "6883.4" "5958.4" "6738.5" "5065.8" "6207.9" "6422.5" "1988.5" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1741293636862823993" "False" "High" "IsMasterProtein" "Q5T1M5" "FK506-binding protein 15 OS=Homo sapiens OX=9606 GN=FKBP15 PE=1 SV=2" "0.000" "False" "184.374" "35" "33" "56" "33" "1219" "133.5" "5.20" "235.05" "33" "transport" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00254" "23307" "ENSG00000119321" "FKBP15" "hsa:23307; Q05DK8; Q5T1M2; Q5T1M5; Q6DD85; Q9Y4D0" "TYROBP causal network in microglia" "" "1" "0" "1.009" "0.974" "1.002" "1.042" "0.984" "1.039" "1.039" "0.990" "1.121" "4607.6" "4647.0" "4486.5" "4619.1" "4799.7" "4534.4" "4786.2" "4786.9" "4560.2" "5164.3" "" "" "" "" "" "" "" "" "" "" "4142.7" "3760.1" "4058.2" "4508.9" "3960.8" "4534.4" "3583.8" "4228.1" "4080.5" "1843.5" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338610440228744590" "False" "High" "IsMasterProtein" "Q13620" "Cullin-4B OS=Homo sapiens OX=9606 GN=CUL4B PE=1 SV=4" "0.000" "False" "184.074" "47" "44" "71" "30" "913" "103.9" "7.37" "261.51" "44" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8450" "ENSG00000158290" "CUL4B" "B1APK5; B3KVX4; B7Z5K8; hsa:8450; Q13620; Q6PIE4; Q6UP07; Q7Z673; Q9BY37; Q9UEB7; Q9UED7" "Mesodermal commitment pathway; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "14" "1.033" "1.002" "0.966" "1.032" "0.929" "1.000" "1.016" "0.982" "0.825" "8442.4" "8724.5" "8463.3" "8159.4" "8713.9" "7839.4" "8445.5" "8580.3" "8290.6" "6966.9" "" "" "" "" "" "" "" "" "" "" "7590.5" "7059.6" "7655.3" "7964.7" "7190.9" "7839.4" "6323.8" "7578.7" "7418.4" "2487.0" "40" "40" "40" "40" "40" "40" "40" "40" "40" "40" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-537602968940689111" "False" "High" "IsMasterProtein" "P30153" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R1A PE=1 SV=4" "0.000" "False" "183.137" "55" "28" "102" "20" "589" "65.3" "5.11" "367.90" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02985" "5518" "ENSG00000105568" "PPP2R1A" "hsa:5518; P30153; Q13773; Q6ICQ3; Q96DH3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "50" "7" "1.020" "1.019" "1.024" "1.031" "1.008" "1.080" "1.033" "1.015" "0.816" "7723.3" "7880.1" "7873.0" "7911.0" "7965.6" "7786.1" "8340.0" "7976.5" "7838.2" "6302.3" "" "" "" "" "" "" "" "" "" "" "6944.0" "6376.3" "7121.4" "7722.2" "6573.4" "7786.1" "6244.8" "7045.4" "7013.5" "2249.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462391840116260305" "False" "High" "IsMasterProtein" "Q05086" "Ubiquitin-protein ligase E3A OS=Homo sapiens OX=9606 GN=UBE3A PE=1 SV=4" "0.000" "False" "182.985" "46" "33" "64" "33" "875" "100.6" "5.22" "252.31" "33" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00632, Pf16558" "7337" "ENSG00000114062" "UBE3A" "A8K8Z9; hsa:7337; P78355; Q05086; Q93066; Q9UEP4; Q9UEP5; Q9UEP6; Q9UEP7; Q9UEP8; Q9UEP9" "Androgen receptor signaling pathway; MECP2 and associated Rett syndrome; Prader-Willi and Angelman syndrome; Synaptic signaling pathways associated with autism spectrum disorder" "Antigen processing: Ubiquitination & Proteasome degradation" "5" "0" "1.023" "0.998" "0.958" "1.029" "0.984" "1.016" "1.002" "0.986" "0.905" "5699.8" "5828.5" "5688.9" "5461.8" "5863.9" "5607.5" "5788.9" "5711.4" "5620.2" "5156.7" "" "" "" "" "" "" "" "" "" "" "5124.7" "4716.2" "5145.8" "5331.4" "4839.0" "5607.5" "4334.6" "5044.6" "5028.9" "1840.8" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7460100142715479081" "False" "High" "IsMasterProtein" "P09960" "Leukotriene A-4 hydrolase OS=Homo sapiens OX=9606 GN=LTA4H PE=1 SV=2" "0.000" "False" "182.049" "56" "28" "68" "28" "611" "69.2" "6.18" "286.49" "28" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf09127, Pf17900" "4048" "ENSG00000111144" "LTA4H" "B4DNQ9; F8VV40; hsa:4048; P09960; Q6IAT6; Q9UCT7" "Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Biosynthesis of protectins; Synthesis of Leukotrienes (LT) and Eoxins (EX); Biosynthesis of D-series resolvins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins" "12" "0" "1.034" "1.015" "1.051" "1.009" "0.977" "1.015" "1.001" "1.033" "0.801" "7670.2" "7929.6" "7788.3" "8063.6" "7741.9" "7493.7" "7783.3" "7675.9" "7919.8" "6143.7" "" "" "" "" "" "" "" "" "" "" "6896.2" "6416.4" "7044.8" "7871.2" "6388.7" "7493.7" "5827.9" "6779.8" "7086.6" "2193.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4305624722430213023" "False" "High" "IsMasterProtein" "Q9H4A3" "Serine/threonine-protein kinase WNK1 OS=Homo sapiens OX=9606 GN=WNK1 PE=1 SV=2" "0.000" "False" "181.678" "18" "38" "70" "32" "2382" "250.6" "6.34" "263.01" "38" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf12202" "65125" "ENSG00000060237" "WNK1" "A1L4B0; C5HTZ5; C5HTZ6; C5HTZ7; H6WZW3; hsa:65125; O15052; P54963; Q4VBX9; Q6IFS5; Q86WL5; Q8N673; Q96CZ6; Q9H4A3; Q9P1S9" "Ciliary landscape" "Stimuli-sensing channels" "2" "5" "1.011" "0.974" "0.985" "1.008" "0.933" "0.993" "0.984" "0.962" "0.815" "5947.3" "6011.7" "5792.9" "5858.7" "5995.5" "5548.4" "5908.5" "5854.4" "5721.4" "4844.4" "" "" "" "" "" "" "" "" "" "" "5347.2" "4864.4" "5239.8" "5718.9" "4947.6" "5548.4" "4424.1" "5170.9" "5119.5" "1729.3" "35" "35" "35" "35" "35" "35" "35" "35" "35" "35" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7263541365096533312" "False" "High" "IsMasterProtein" "Q13435" "Splicing factor 3B subunit 2 OS=Homo sapiens OX=9606 GN=SF3B2 PE=1 SV=2" "0.000" "False" "181.294" "46" "36" "70" "36" "895" "100.2" "5.67" "247.28" "36" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02037, Pf04037, Pf04046" "10992" "ENSG00000087365" "SF3B2" "A8K485; B4DT19; hsa:10992; Q13435; Q7L4T5; Q7Z627; Q969K1; Q96CM6; Q9BWD2" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.033" "1.029" "0.985" "0.995" "1.101" "0.982" "1.057" "1.009" "0.799" "6362.1" "6569.6" "6546.9" "6265.9" "6331.6" "7007.8" "6245.7" "6726.4" "6416.8" "5081.0" "" "" "" "" "" "" "" "" "" "" "5720.2" "5315.9" "5921.9" "6116.4" "5224.9" "7007.8" "4676.6" "5941.2" "5741.7" "1813.8" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1422761924457517511" "False" "High" "IsMasterProtein" "A3KN83" "Protein strawberry notch homolog 1 OS=Homo sapiens OX=9606 GN=SBNO1 PE=1 SV=1" "0.000" "False" "181.088" "33" "38" "59" "38" "1393" "154.2" "7.88" "223.75" "38" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13871, Pf13872" "55206" "ENSG00000139697" "SBNO1" "A3KN83; Q05C06; Q3ZTS3; Q9H3T8; Q9NVB2" "" "" "0" "0" "1.025" "1.037" "1.020" "1.056" "1.008" "1.018" "1.022" "1.053" "0.949" "4215.8" "4322.5" "4372.3" "4299.9" "4449.8" "4249.3" "4292.4" "4309.4" "4441.0" "4002.8" "" "" "" "" "" "" "" "" "" "" "3790.4" "3497.6" "3954.9" "4197.3" "3672.0" "4249.3" "3214.0" "3806.4" "3973.8" "1428.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3988620745573507049" "False" "High" "IsMasterProtein" "P55786" "Puromycin-sensitive aminopeptidase OS=Homo sapiens OX=9606 GN=NPEPPS PE=1 SV=2" "0.000" "False" "181.035" "41" "33" "74" "33" "919" "103.2" "5.72" "260.84" "33" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "9520" "ENSG00000141279" "NPEPPS" "B7Z463; hsa:9520; P55786; Q6P145; Q9NP16; Q9UEM2" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.970" "0.981" "0.987" "0.974" "0.960" "1.024" "0.904" "0.954" "1.041" "6524.5" "6325.8" "6399.9" "6440.0" "6356.7" "6263.8" "6680.1" "5899.7" "6227.4" "6789.4" "" "" "" "" "" "" "" "" "" "" "5866.2" "5118.6" "5788.9" "6286.3" "5245.6" "6263.8" "5001.9" "5211.0" "5572.2" "2423.6" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8282495750123490209" "False" "High" "IsMasterProtein" "Q96AE4" "Far upstream element-binding protein 1 OS=Homo sapiens OX=9606 GN=FUBP1 PE=1 SV=3" "0.000" "False" "180.765" "51" "28" "93" "22" "644" "67.5" "7.61" "349.91" "28" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf09005" "8880" "ENSG00000162613" "FUBP1" "hsa:8880; Q12828; Q96AE4" "" "" "0" "1" "0.930" "0.951" "0.988" "1.020" "1.021" "1.006" "1.065" "1.002" "0.815" "6444.1" "5993.9" "6129.9" "6369.7" "6575.5" "6580.2" "6480.2" "6864.8" "6459.5" "5253.1" "" "" "" "" "" "" "" "" "" "" "5793.9" "4850.1" "5544.7" "6217.7" "5426.2" "6580.2" "4852.2" "6063.5" "5779.9" "1875.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-160533791377362281" "False" "High" "IsMasterProtein" "P07195" "L-lactate dehydrogenase B chain OS=Homo sapiens OX=9606 GN=LDHB PE=1 SV=2" "0.000" "False" "180.547" "58" "22" "234" "21" "334" "36.6" "6.05" "787.04" "22" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3945" "ENSG00000111716" "LDHB" "hsa:3945; P07195" "Clear cell renal cell carcinoma pathways; CCL18 signaling pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Pyruvate metabolism" "5" "0" "1.005" "0.968" "0.950" "0.782" "0.961" "0.897" "0.989" "0.963" "0.750" "25386.8" "25521.5" "24567.0" "24109.2" "19847.0" "24394.1" "22778.7" "25096.3" "24441.5" "19042.7" "" "" "" "" "" "" "" "" "" "" "22825.2" "20651.1" "22221.7" "23533.9" "16378.1" "24394.1" "17056.2" "22166.7" "21870.0" "6797.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283450593618715734" "False" "High" "IsMasterProtein" "P41240" "Tyrosine-protein kinase CSK OS=Homo sapiens OX=9606 GN=CSK PE=1 SV=1" "0.000" "False" "179.794" "59" "23" "80" "23" "450" "50.7" "7.06" "303.95" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "1445" "ENSG00000103653" "CSK" "P41240; Q2M3N2; Q6FGZ6" "Integrin-mediated cell adhesion; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Phosphorylation of CD3 and TCR zeta chains; PD-1 signaling; Negative regulation of FLT3; GAB1 signalosome; Integrin signaling; RHOH GTPase cycle" "18" "0" "1.005" "0.951" "1.017" "0.983" "0.950" "1.009" "0.984" "0.967" "0.975" "7806.3" "7841.5" "7424.0" "7935.6" "7674.7" "7417.7" "7878.9" "7681.5" "7545.0" "7613.4" "" "" "" "" "" "" "" "" "" "" "7018.6" "6345.1" "6715.3" "7746.3" "6333.3" "7417.7" "5899.5" "6784.8" "6751.2" "2717.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778599060552415361" "False" "High" "IsMasterProtein" "P52272" "Heterogeneous nuclear ribonucleoprotein M OS=Homo sapiens OX=9606 GN=HNRNPM PE=1 SV=3" "0.000" "False" "179.699" "56" "37" "104" "37" "730" "77.5" "8.70" "322.64" "37" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11532" "4670" "ENSG00000099783" "HNRNPM" "hsa:4670; P52272; Q15584; Q8WZ44; Q96H56; Q9BWL9; Q9Y492" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.040" "1.026" "1.057" "0.992" "1.037" "1.112" "0.989" "0.963" "3.089" "6263.4" "6514.8" "6428.0" "6617.4" "6215.2" "6497.4" "6961.8" "6193.9" "6031.2" "19350.4" "" "" "" "" "" "" "" "" "" "" "5631.4" "5271.5" "5814.4" "6459.5" "5128.9" "6497.4" "5212.8" "5470.8" "5396.7" "6907.6" "39" "39" "39" "39" "39" "39" "39" "39" "39" "39" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3391234540397172253" "False" "High" "IsMasterProtein" "Q9H2U1" "ATP-dependent DNA/RNA helicase DHX36 OS=Homo sapiens OX=9606 GN=DHX36 PE=1 SV=2" "0.000" "False" "179.678" "40" "34" "61" "33" "1008" "114.7" "7.68" "238.93" "34" "cell organization and biogenesis;RNA metabolism OR transcription;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "170506" "ENSG00000174953" "DHX36" "B2RB00; hsa:170506; Q70JU3; Q8IYE5; Q9H2U1; Q9P240" "VEGFA-VEGFR2 signaling" "DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "2" "1" "1.028" "1.006" "0.997" "1.014" "0.972" "0.976" "0.965" "0.991" "0.972" "5722.0" "5884.5" "5756.5" "5702.1" "5803.0" "5559.1" "5582.7" "5520.6" "5672.0" "5564.5" "" "" "" "" "" "" "" "" "" "" "5144.7" "4761.5" "5207.0" "5566.0" "4788.7" "5559.1" "4180.2" "4876.1" "5075.3" "1986.4" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4532618803689773049" "False" "High" "IsMasterProtein" "P00491" "Purine nucleoside phosphorylase OS=Homo sapiens OX=9606 GN=PNP PE=1 SV=2" "0.000" "False" "178.648" "82" "19" "87" "19" "289" "32.1" "6.95" "388.92" "19" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf01048" "4860" "ENSG00000198805; ENSG00000291814" "PNP" "B2R8S5; D3DS00; hsa:4860; P00491; Q15160; Q5PZ03" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Purine catabolism; Ribavirin ADME; Purine salvage; Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine" "6" "0" "1.018" "1.038" "1.009" "1.031" "1.010" "1.017" "1.007" "1.035" "0.776" "6858.7" "6984.6" "7118.9" "6921.0" "7073.6" "6924.8" "6976.6" "6905.5" "7096.4" "5323.3" "" "" "" "" "" "" "" "" "" "" "6166.6" "5651.7" "6439.3" "6755.8" "5837.2" "6924.8" "5223.9" "6099.4" "6349.8" "1900.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488092828150113306" "False" "High" "IsMasterProtein" "Q86UX7" "Fermitin family homolog 3 OS=Homo sapiens OX=9606 GN=FERMT3 PE=1 SV=1" "0.000" "False" "178.420" "56" "28" "72" "28" "667" "75.9" "6.98" "269.35" "28" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00169, Pf00373, Pf18124" "83706" "ENSG00000149781" "FERMT3" "hsa:83706; Q86UX7; Q8IUA1; Q8N207; Q9BT48" "Leukocyte-intrinsic Hippo pathway functions" "Platelet degranulation" "2" "0" "0.983" "1.000" "0.942" "1.021" "0.926" "0.968" "0.948" "0.988" "0.864" "6161.3" "6056.5" "6164.1" "5806.9" "6291.9" "5703.5" "5963.7" "5843.6" "6089.7" "5324.6" "" "" "" "" "" "" "" "" "" "" "5539.6" "4900.7" "5575.6" "5668.3" "5192.2" "5703.5" "4465.5" "5161.5" "5449.0" "1900.7" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7305935062523076867" "False" "High" "IsMasterProtein" "Q9Y3Z3" "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 OS=Homo sapiens OX=9606 GN=SAMHD1 PE=1 SV=2" "0.000" "False" "178.344" "63" "33" "64" "32" "626" "72.2" "7.14" "233.44" "33" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01966, Pf07647" "25939" "ENSG00000101347" "SAMHD1" "B4E2A5; E1P5V2; hsa:25939; Q5JXG8; Q8N491; Q9H004; Q9H005; Q9H3U9; Q9Y3Z3" "" "Interferon alpha/beta signaling; Nucleotide catabolism" "2" "0" "0.992" "0.981" "1.017" "1.006" "0.946" "1.036" "0.996" "1.000" "0.964" "4852.9" "4815.6" "4760.4" "4934.1" "4882.0" "4593.1" "5027.6" "4833.3" "4852.6" "4677.1" "" "" "" "" "" "" "" "" "" "" "4363.2" "3896.6" "4305.9" "4816.3" "4028.7" "4593.1" "3764.6" "4269.1" "4342.1" "1669.6" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2214005141303334461" "False" "High" "IsMasterProtein" "P12956" "X-ray repair cross-complementing protein 6 OS=Homo sapiens OX=9606 GN=XRCC6 PE=1 SV=2" "0.000" "False" "178.159" "50" "29" "83" "29" "609" "69.8" "6.64" "307.95" "29" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf02735, Pf03730, Pf03731" "2547" "ENSG00000196419" "XRCC6" "B1AHC8; hsa:2547; P12956; Q6FG89; Q9UCQ2; Q9UCQ3" "Non-homologous end joining; DNA repair pathways, full network; Primary ovarian insufficiency; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.995" "0.949" "1.011" "0.972" "0.915" "1.022" "0.963" "0.936" "2.067" "9520.2" "9474.2" "9036.8" "9626.1" "9256.5" "8713.2" "9734.2" "9169.6" "8911.7" "19678.6" "" "" "" "" "" "" "" "" "" "" "8559.6" "7666.2" "8174.1" "9396.5" "7638.7" "8713.2" "7288.8" "8099.2" "7974.2" "7024.7" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4804495115062908755" "False" "High" "IsMasterProtein" "P41252" "Isoleucine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=IARS1 PE=1 SV=2" "0.000" "False" "177.468" "34" "38" "58" "38" "1262" "144.4" "6.15" "229.30" "38" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00133, Pf08264, Pf19302" "3376" "ENSG00000196305; ENSG00000291356" "IARS1" "A8KAE9; hsa:3376; P41252; Q5TCD0; Q7Z3T4; Q9H588" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "1.025" "1.009" "0.993" "0.965" "1.006" "1.050" "0.943" "1.083" "2.732" "3768.6" "3862.5" "3803.6" "3742.7" "3636.8" "3789.9" "3956.4" "3552.9" "4083.3" "10294.1" "" "" "" "" "" "" "" "" "" "" "3388.3" "3125.4" "3440.5" "3653.4" "3001.2" "3789.9" "2962.5" "3138.2" "3653.7" "3674.7" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262993958771163174" "False" "High" "IsMasterProtein" "P40926" "Malate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=MDH2 PE=1 SV=3" "0.000" "False" "177.154" "72" "24" "150" "24" "338" "35.5" "8.68" "570.03" "24" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "4191" "ENSG00000146701" "MDH2" "A8K414; B2RE78; B4DE44; E9PDB2; O43682; P40926" "Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; 7q11.23 distal copy number variation; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Gluconeogenesis; Citric acid cycle (TCA cycle)" "10" "0" "0.973" "0.968" "1.057" "0.993" "0.962" "0.996" "1.002" "0.975" "0.755" "15136.5" "14735.0" "14656.0" "15992.2" "15023.2" "14555.9" "15080.7" "15173.1" "14759.0" "11420.5" "" "" "" "" "" "" "" "" "" "" "13609.2" "11923.1" "13256.9" "15610.6" "12397.4" "14555.9" "11292.1" "13401.9" "13206.2" "4076.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771455182534441899" "False" "High" "IsMasterProtein" "P11137" "Microtubule-associated protein 2 OS=Homo sapiens OX=9606 GN=MAP2 PE=1 SV=4" "0.000" "False" "175.740" "31" "45" "61" "45" "1827" "199.4" "4.91" "233.18" "45" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00418, Pf08377" "4133" "ENSG00000078018" "MAP2" "hsa:4133; P11137; Q17S04; Q8IUX2; Q99975; Q99976" "Melatonin metabolism and effects; MAPK cascade; Neurogenesis regulation in the olfactory epithelium; Cell lineage map for neuronal differentiation; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "5" "0" "0.969" "0.945" "0.990" "1.008" "0.978" "1.024" "1.019" "0.960" "0.845" "5706.4" "5529.6" "5395.2" "5648.6" "5751.0" "5579.2" "5846.1" "5812.4" "5478.8" "4821.9" "" "" "" "" "" "" "" "" "" "" "5130.6" "4474.4" "4880.1" "5513.8" "4745.9" "5579.2" "4377.4" "5133.9" "4902.4" "1721.3" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951923410761951319" "False" "High" "IsMasterProtein" "Q9UQ80" "Proliferation-associated protein 2G4 OS=Homo sapiens OX=9606 GN=PA2G4 PE=1 SV=3" "0.000" "False" "174.485" "66" "27" "124" "26" "394" "43.8" "6.55" "468.53" "27" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00557" "5036" "ENSG00000170515" "PA2G4" "hsa:5036; O43846; Q9UM59; Q9UQ80" "" "Neutrophil degranulation" "1" "0" "1.017" "0.998" "1.089" "0.988" "1.062" "1.037" "1.028" "1.028" "1.178" "10007.7" "10177.1" "9988.3" "10897.7" "9882.8" "10628.7" "10377.9" "10291.6" "10288.7" "11789.4" "" "" "" "" "" "" "" "" "" "" "8997.9" "8235.0" "9034.7" "10637.7" "8155.4" "10628.7" "7770.7" "9090.2" "9206.2" "4208.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994958122545782914" "False" "High" "IsMasterProtein" "Cont_Q9XSJ4" "Alpha-enolase OS=Bos taurus OX=9913 GN=ENO1 PE=1 SV=4" "0.000" "True" "174.164" "54" "20" "224" "2" "434" "47.3" "6.80" "878.97" "20" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "281141" "" "ENO1" "bta:281141; Q3SYW4; Q9XSJ4" "" "" "0" "0" "1.086" "1.075" "0.953" "1.194" "1.074" "1.335" "0.947" "1.015" "0.964" "174.8" "189.8" "187.8" "166.5" "208.8" "187.7" "233.3" "165.4" "177.4" "168.4" "" "" "" "" "" "" "" "" "" "" "157.2" "153.5" "169.9" "162.5" "172.3" "187.7" "174.7" "146.1" "158.8" "60.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4754969911618934256" "False" "High" "IsMasterProtein" "Q5H9R7" "Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PPP6R3 PE=1 SV=2" "0.000" "False" "173.708" "42" "30" "56" "29" "873" "97.6" "4.60" "220.73" "30" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "55291" "ENSG00000110075" "PPP6R3" "hsa:55291; Q3B7I1; Q3I4Y0; Q3KR35; Q5H9R7; Q68CR3; Q7L4R8; Q8N3B2; Q96MB2; Q9H2K5; Q9H2K6; Q9HCL4; Q9NUY3" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "1" "0.998" "0.985" "0.970" "1.008" "0.961" "1.013" "1.010" "0.999" "0.831" "5710.7" "5699.2" "5622.7" "5539.9" "5758.9" "5486.9" "5783.4" "5766.9" "5706.4" "4745.2" "" "" "" "" "" "" "" "" "" "" "5134.5" "4611.6" "5085.9" "5407.8" "4752.4" "5486.9" "4330.5" "5093.7" "5106.1" "1693.9" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8732346175470674622" "False" "High" "IsMasterProtein" "Q86UP2" "Kinectin OS=Homo sapiens OX=9606 GN=KTN1 PE=1 SV=1" "0.000" "False" "173.374" "35" "44" "53" "44" "1357" "156.2" "5.64" "200.50" "44" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "cytoskeletal activity" "Pf05104" "3895" "ENSG00000126777" "KTN1" "B4DZ88; hsa:3895; Q13999; Q14707; Q15387; Q17RZ5; Q5GGW3; Q86UP2; Q86W57" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle; RHOG GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RHO GTPases activate KTN1" "11" "0" "1.044" "1.042" "1.091" "1.102" "1.053" "1.165" "1.053" "1.035" "1.472" "4094.1" "4275.3" "4266.3" "4466.8" "4512.3" "4311.5" "4769.5" "4309.6" "4238.1" "6024.8" "" "" "" "" "" "" "" "" "" "" "3681.0" "3459.5" "3859.0" "4360.2" "3723.6" "4311.5" "3571.3" "3806.6" "3792.2" "2150.7" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2726683976815450871" "False" "High" "IsMasterProtein" "P00338" "L-lactate dehydrogenase A chain OS=Homo sapiens OX=9606 GN=LDHA PE=1 SV=2" "0.000" "False" "172.867" "65" "27" "242" "26" "332" "36.7" "8.27" "761.62" "27" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00056, Pf02866" "3939" "ENSG00000134333; ENSG00000288299" "LDHA" "B4DKQ2; B7Z5E3; D3DQY3; F8W819; hsa:3939; P00338; Q53G53; Q6IBM7; Q6ZNV1; Q9UDE8; Q9UDE9" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Amino acid metabolism; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Glycolysis in senescence; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Lactate shuttle in glial cells; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders" "Pyruvate metabolism" "20" "1" "1.027" "1.046" "1.064" "1.003" "0.980" "1.001" "1.027" "1.045" "0.797" "22055.3" "22646.4" "23066.1" "23471.6" "22126.8" "21618.0" "22072.7" "22653.5" "23041.5" "17570.1" "" "" "" "" "" "" "" "" "" "" "19829.8" "18324.6" "20864.1" "22911.6" "18259.5" "21618.0" "16527.5" "20009.0" "20617.3" "6272.0" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4107495286689168051" "False" "High" "IsMasterProtein" "P42566" "Epidermal growth factor receptor substrate 15 OS=Homo sapiens OX=9606 GN=EPS15 PE=1 SV=2" "0.000" "False" "172.515" "47" "33" "58" "33" "896" "98.6" "4.64" "233.04" "33" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "" "2060" "ENSG00000085832" "EPS15" "B2R8J7; D3DPJ2; hsa:2060; P42566; Q5SRH4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "8" "0" "0.979" "0.966" "0.967" "0.997" "0.933" "1.001" "0.958" "0.985" "1.108" "5221.2" "5111.8" "5042.0" "5050.3" "5203.9" "4873.2" "5225.8" "5000.5" "5142.3" "5785.6" "" "" "" "" "" "" "" "" "" "" "4694.3" "4136.3" "4560.6" "4929.7" "4294.4" "4873.2" "3913.0" "4416.7" "4601.3" "2065.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2749950876556130584" "False" "High" "IsMasterProtein" "P0DMV9" "Heat shock 70 kDa protein 1B OS=Homo sapiens OX=9606 GN=HSPA1B PE=1 SV=1" "0.000" "False" "172.329" "50" "29" "109" "17" "641" "70.0" "5.66" "376.30" "29" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00012" "3303; 3304" "ENSG00000204388; ENSG00000212866; ENSG00000224501; ENSG00000231555; ENSG00000232804" "HSPA1B" "B4E3B6; hsa:3303; hsa:3304; P08107; P0DMV9; P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0" "Apoptosis modulation and signaling; Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Measles virus infection" "PKR-mediated signaling; Neutrophil degranulation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "12" "7" "1.017" "1.124" "1.008" "0.992" "1.114" "0.993" "1.003" "1.101" "0.840" "5848.0" "5950.0" "6575.5" "5894.0" "5803.2" "6514.1" "5808.1" "5866.6" "6436.9" "4914.7" "" "" "" "" "" "" "" "" "" "" "5257.9" "4814.6" "5947.8" "5753.4" "4788.9" "6514.1" "4348.9" "5181.8" "5759.7" "1754.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7200124319077870265" "False" "High" "IsMasterProtein" "P35998" "26S proteasome regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMC2 PE=1 SV=3" "0.000" "False" "171.525" "64" "24" "70" "24" "433" "48.6" "5.95" "251.56" "24" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862, Pf21236" "5701" "ENSG00000161057" "PSMC2" "A4D0Q1; B7Z5E2; hsa:5701; P35998; Q3LIA5; Q9UDI3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.999" "0.979" "0.951" "0.985" "0.960" "1.018" "1.005" "0.995" "0.876" "5390.5" "5387.0" "5278.5" "5125.1" "5308.9" "5175.0" "5487.8" "5418.3" "5364.3" "4722.8" "" "" "" "" "" "" "" "" "" "" "4846.6" "4359.0" "4774.5" "5002.8" "4381.0" "5175.0" "4109.1" "4785.8" "4799.9" "1685.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1968544072233028588" "False" "High" "IsMasterProtein" "P23246" "Splicing factor, proline- and glutamine-rich OS=Homo sapiens OX=9606 GN=SFPQ PE=1 SV=2" "0.000" "False" "171.253" "32" "27" "101" "26" "707" "76.1" "9.44" "357.90" "27" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "6421" "ENSG00000116560" "SFPQ" "hsa:6421; P23246; P30808; Q5SZ71" "mRNA processing; Type 2 papillary renal cell carcinoma" "Suppression of apoptosis; PTK6 Regulates Proteins Involved in RNA Processing" "4" "1" "1.020" "0.997" "1.008" "0.985" "1.006" "0.988" "0.988" "0.906" "1.550" "8509.7" "8682.2" "8486.0" "8576.6" "8383.3" "8563.2" "8409.0" "8405.4" "7711.8" "13192.4" "" "" "" "" "" "" "" "" "" "" "7651.1" "7025.3" "7675.9" "8372.0" "6918.1" "8563.2" "6296.4" "7424.2" "6900.4" "4709.3" "37" "37" "37" "37" "37" "37" "37" "37" "37" "37" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546682892855641805" "False" "High" "IsMasterProtein" "P12268" "Inosine-5'-monophosphate dehydrogenase 2 OS=Homo sapiens OX=9606 GN=IMPDH2 PE=1 SV=2" "0.000" "False" "170.966" "53" "25" "64" "23" "514" "55.8" "6.90" "271.92" "25" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3615" "ENSG00000178035" "IMPDH2" "hsa:3615; P12268; Q6LEF3" "Rett syndrome" "Neutrophil degranulation; Potential therapeutics for SARS; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "5" "2" "0.995" "0.916" "1.077" "0.947" "0.957" "0.974" "1.041" "0.993" "0.798" "8398.6" "8354.7" "7695.6" "9044.3" "7952.3" "8038.5" "8183.1" "8742.7" "8343.6" "6701.9" "" "" "" "" "" "" "" "" "" "" "7551.2" "6760.3" "6960.9" "8828.5" "6562.4" "8038.5" "6127.3" "7722.1" "7465.8" "2392.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835450799000805125" "False" "High" "IsMasterProtein" "Q8N1F7" "Nuclear pore complex protein Nup93 OS=Homo sapiens OX=9606 GN=NUP93 PE=1 SV=2" "0.000" "False" "170.698" "45" "35" "63" "35" "819" "93.4" "5.72" "228.52" "35" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf04097" "9688" "ENSG00000102900" "NUP93" "B3KPQ8; hsa:9688; Q14705; Q8N1F7" "" "Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.093" "1.112" "1.022" "1.091" "1.089" "1.107" "1.029" "1.114" "1.845" "3676.5" "4018.4" "4088.8" "3757.4" "4012.0" "4001.9" "4071.6" "3783.3" "4096.0" "6782.3" "" "" "" "" "" "" "" "" "" "" "3305.6" "3251.6" "3698.5" "3667.7" "3310.8" "4001.9" "3048.7" "3341.6" "3665.1" "2421.1" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2832146552711634492" "False" "High" "IsMasterProtein" "Q02218" "2-oxoglutarate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=OGDH PE=1 SV=3" "0.000" "False" "170.589" "41" "34" "59" "34" "1023" "115.9" "6.86" "222.77" "34" "protein metabolism;other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676, Pf02779, Pf16078, Pf16870" "4967" "ENSG00000105953" "OGDH" "B4E2U9; D3DVL0; E9PBM1; hsa:4967; Q02218; Q96DD3; Q9UDX0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Thiamine metabolic pathways; 7q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Glyoxylate metabolism and glycine degradation; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.948" "0.882" "0.995" "0.899" "0.815" "1.001" "0.853" "0.792" "1.053" "6377.4" "6048.9" "5628.0" "6346.7" "5733.6" "5199.0" "6382.2" "5438.1" "5051.4" "6712.6" "" "" "" "" "" "" "" "" "" "" "5733.9" "4894.5" "5090.7" "6195.3" "4731.4" "5199.0" "4778.9" "4803.2" "4520.0" "2396.2" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9125415552757105331" "False" "High" "IsMasterProtein" "Q05639" "Elongation factor 1-alpha 2 OS=Homo sapiens OX=9606 GN=EEF1A2 PE=1 SV=1" "0.000" "False" "170.173" "61" "24" "148" "11" "463" "50.4" "9.03" "546.63" "24" "protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144" "1917" "ENSG00000101210" "EEF1A2" "B5BUF3; E1P5J1; hsa:1917; P54266; Q05639; Q0VGC7" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "1.020" "1.012" "1.035" "0.966" "0.946" "0.970" "0.979" "1.024" "0.766" "3742.1" "3815.2" "3788.0" "3874.2" "3615.2" "3541.7" "3631.2" "3662.2" "3832.2" "2865.9" "" "" "" "" "" "" "" "" "" "" "3364.5" "3087.1" "3426.3" "3781.7" "2983.4" "3541.7" "2719.0" "3234.7" "3429.1" "1023.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437948072660631583" "False" "High" "IsMasterProtein" "O60664" "Perilipin-3 OS=Homo sapiens OX=9606 GN=PLIN3 PE=1 SV=3" "0.000" "False" "169.951" "66" "22" "78" "22" "434" "47.0" "5.44" "324.06" "22" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf03036" "10226" "ENSG00000105355" "PLIN3" "A8K4Y9; hsa:10226; K7EQF4; O60664; Q53G77; Q9BS03; Q9UBD7; Q9UP92" "" "Late endosomal microautophagy; Triglyceride catabolism; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle; Lipophagy; Chaperone Mediated Autophagy" "6" "0" "1.042" "0.989" "1.067" "1.049" "0.987" "1.090" "1.088" "1.062" "0.835" "5209.1" "5426.4" "5149.3" "5559.8" "5462.2" "5139.6" "5680.2" "5668.0" "5530.7" "4349.4" "" "" "" "" "" "" "" "" "" "" "4683.5" "4390.9" "4657.7" "5427.1" "4507.5" "5139.6" "4253.2" "5006.3" "4948.9" "1552.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1724337932377857957" "False" "High" "IsMasterProtein" "Q13619" "Cullin-4A OS=Homo sapiens OX=9606 GN=CUL4A PE=1 SV=3" "0.000" "False" "169.748" "53" "41" "71" "27" "759" "87.6" "8.13" "250.65" "41" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8451" "ENSG00000139842" "CUL4A" "A2A2W2; hsa:8451; O75834; Q13619; Q589T6; Q5TC62; Q6UP08; Q9UP17" "Hippo-Merlin signaling dysregulation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of Incision Complex in GG-NER; Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; DNA Damage Recognition in GG-NER; Dual Incision in GG-NER" "13" "0" "1.005" "0.965" "0.991" "1.023" "0.970" "0.981" "1.011" "0.976" "0.838" "3609.2" "3627.1" "3481.8" "3577.5" "3691.4" "3501.5" "3542.2" "3648.4" "3521.9" "3023.2" "" "" "" "" "" "" "" "" "" "" "3245.0" "2934.9" "3149.4" "3492.2" "3046.2" "3501.5" "2652.3" "3222.5" "3151.4" "1079.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4840156573364048016" "False" "High" "IsMasterProtein" "Q58FF7" "Putative heat shock protein HSP 90-beta-3 OS=Homo sapiens OX=9606 GN=HSP90AB3P PE=5 SV=1" "0.000" "False" "169.316" "29" "26" "220" "1" "597" "68.3" "4.79" "700.27" "26" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00183" "" "" "HSP90AB3P" "Q58FF7" "" "" "0" "0" "1.393" "1.124" "1.048" "1.564" "1.448" "2.007" "1.434" "0.952" "1.355" "25.3" "35.2" "28.4" "26.5" "39.6" "36.6" "50.8" "36.3" "24.1" "34.3" "" "" "" "" "" "" "" "" "" "" "22.7" "28.5" "25.7" "25.9" "32.6" "36.6" "38.0" "32.0" "21.5" "12.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868363632382073498" "False" "High" "IsMasterProtein" "Q6UB35" "Monofunctional C1-tetrahydrofolate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD1L PE=1 SV=1" "0.000" "False" "169.120" "36" "31" "59" "29" "978" "105.7" "8.06" "224.83" "31" "other metabolic processes;developmental processes" "cytosol;mitochondrion" "other molecular function" "Pf00763, Pf01268, Pf02882" "25902" "ENSG00000120254" "MTHFD1L" "hsa:25902; Q2TBF3; Q6UB35; Q8WVW0; Q96HG8; Q9H789; Q9UFU8" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "3" "1" "1.045" "0.967" "0.999" "1.014" "0.968" "1.001" "1.026" "1.011" "0.827" "6122.2" "6396.0" "5920.5" "6114.1" "6208.3" "5926.5" "6127.3" "6279.9" "6191.7" "5061.0" "" "" "" "" "" "" "" "" "" "" "5504.5" "5175.4" "5355.3" "5968.2" "5123.2" "5926.5" "4588.0" "5546.8" "5540.3" "1806.6" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5486623488286150829" "False" "High" "IsMasterProtein" "Q9UBT2" "SUMO-activating enzyme subunit 2 OS=Homo sapiens OX=9606 GN=UBA2 PE=1 SV=2" "0.000" "False" "169.113" "48" "28" "69" "28" "640" "71.2" "5.29" "255.06" "28" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00899, Pf14732, Pf16195" "10054" "ENSG00000126261" "UBA2" "B3KWB9; hsa:10054; O95605; Q59H87; Q6IBP6; Q9NTJ1; Q9UBT2; Q9UED2" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "0.998" "0.985" "0.995" "0.996" "0.964" "1.004" "0.990" "1.007" "0.813" "7995.4" "7977.5" "7873.6" "7956.3" "7965.5" "7705.3" "8027.4" "7916.4" "8050.3" "6497.4" "" "" "" "" "" "" "" "" "" "" "7188.7" "6455.1" "7121.9" "7766.4" "6573.3" "7705.3" "6010.7" "6992.3" "7203.4" "2319.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8610404900026586522" "False" "High" "IsMasterProtein" "P27797" "Calreticulin OS=Homo sapiens OX=9606 GN=CALR PE=1 SV=1" "0.000" "False" "169.091" "64" "26" "99" "26" "417" "48.1" "4.44" "393.89" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00262" "811" "ENSG00000179218" "CALR" "hsa:811; P27797; Q6IAT4; Q9UDG2" "Androgen receptor signaling pathway; Complement system; Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; GDNF signaling; Calcium regulation in cardiac cells" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Scavenging by Class A Receptors; Assembly of Viral Components at the Budding Site; Scavenging by Class F Receptors; ATF6 (ATF6-alpha) activates chaperone genes; Calnexin/calreticulin cycle" "13" "0" "1.007" "0.991" "1.048" "1.010" "1.052" "1.034" "1.045" "1.053" "1.172" "9562.6" "9631.4" "9472.4" "10023.8" "9656.2" "10063.9" "9886.1" "9997.1" "10072.6" "11204.1" "" "" "" "" "" "" "" "" "" "" "8597.8" "7793.4" "8568.1" "9784.6" "7968.5" "10063.9" "7402.5" "8830.1" "9012.9" "3999.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1437686464987713845" "False" "High" "IsMasterProtein" "Q9BUF5" "Tubulin beta-6 chain OS=Homo sapiens OX=9606 GN=TUBB6 PE=1 SV=1" "0.000" "False" "168.980" "54" "20" "170" "7" "446" "49.8" "4.88" "440.83" "20" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "84617" "ENSG00000176014" "TUBB6" "B3KM76; hsa:84617; Q9BUF5; Q9HA42" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Prefoldin mediated transfer of substrate to CCT/TriC; Recruitment of NuMA to mitotic centrosomes; Assembly and cell surface presentation of NMDA receptors; Sealing of the nuclear envelope (NE) by ESCRT-III; HCMV Early Events; Post-chaperonin tubulin folding pathway; Intraflagellar transport; Recycling pathway of L1; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; RHO GTPases activate IQGAPs; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; Activation of AMPK downstream of NMDARs; Aggrephagy; Kinesins; PKR-mediated signaling; Hedgehog 'off' state" "35" "0" "1.015" "1.006" "1.077" "1.031" "1.041" "1.056" "1.038" "1.059" "0.845" "2221.9" "2255.0" "2235.9" "2392.8" "2290.8" "2313.2" "2345.9" "2306.1" "2352.9" "1878.6" "" "" "" "" "" "" "" "" "" "" "1997.7" "1824.7" "2022.4" "2335.7" "1890.4" "2313.2" "1756.5" "2036.9" "2105.4" "670.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7405227159340641842" "False" "High" "IsMasterProtein" "P62195" "26S proteasome regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMC5 PE=1 SV=1" "0.000" "False" "168.299" "67" "27" "92" "25" "406" "45.6" "7.55" "335.58" "27" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf16450, Pf17862" "5705" "ENSG00000087191" "PSMC5" "A8K3Z3; A8K763; hsa:5705; O35051; O43208; P47210; P52915; P52916; P62195" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "2" "1.003" "0.983" "0.965" "0.953" "0.961" "0.957" "0.983" "0.995" "0.859" "9141.6" "9168.0" "8989.6" "8822.2" "8716.4" "8785.9" "8747.9" "8987.1" "9096.9" "7855.4" "" "" "" "" "" "" "" "" "" "" "8219.1" "7418.4" "8131.4" "8611.7" "7192.9" "8785.9" "6550.2" "7938.0" "8139.8" "2804.2" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4087674429968217888" "False" "High" "IsMasterProtein" "P63010" "AP-2 complex subunit beta OS=Homo sapiens OX=9606 GN=AP2B1 PE=1 SV=1" "0.000" "False" "167.818" "35" "31" "56" "13" "937" "104.5" "5.38" "220.05" "31" "transport;developmental processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02883, Pf09066" "163" "ENSG00000006125" "AP2B1" "A6NJP3; hsa:163; P21851; P63010; Q7Z451; Q96J19" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Markers of kidney cell lineage; 17q12 copy number variation syndrome" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; VLDLR internalisation and degradation; WNT5A-dependent internalization of FZD4; Recycling pathway of L1; Retrograde neurotrophin signalling; Potential therapeutics for SARS; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2" "20" "0" "1.070" "1.068" "1.001" "1.073" "1.040" "1.056" "0.974" "1.077" "0.899" "1499.4" "1604.6" "1600.6" "1500.9" "1608.6" "1558.8" "1583.4" "1460.2" "1614.5" "1348.1" "" "" "" "" "" "" "" "" "" "" "1348.1" "1298.4" "1447.8" "1465.1" "1327.4" "1558.8" "1185.6" "1289.7" "1444.7" "481.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4866414538171077072" "False" "High" "IsMasterProtein" "P31146" "Coronin-1A OS=Homo sapiens OX=9606 GN=CORO1A PE=1 SV=4" "0.000" "False" "167.574" "45" "29" "131" "28" "461" "51.0" "6.68" "459.05" "29" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf08954, Pf16300" "11151" "ENSG00000102879" "CORO1A" "B2RBL1; hsa:11151; P31146; Q2YD73" "16p11.2 proximal deletion syndrome" "Prevention of phagosomal-lysosomal fusion" "2" "3" "1.001" "0.991" "1.008" "0.959" "0.950" "0.969" "0.994" "0.962" "1.112" "13416.0" "13435.7" "13288.6" "13527.2" "12861.5" "12747.1" "13001.9" "13335.9" "12901.0" "14917.2" "" "" "" "" "" "" "" "" "" "" "12062.3" "10871.7" "12020.0" "13204.4" "10613.5" "12747.1" "9735.5" "11779.1" "11543.7" "5325.0" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4471349255838518587" "False" "High" "IsMasterProtein" "P23526" "Adenosylhomocysteinase OS=Homo sapiens OX=9606 GN=AHCY PE=1 SV=4" "0.000" "False" "167.326" "55" "24" "109" "22" "432" "47.7" "6.34" "382.70" "24" "other metabolic processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00670, Pf05221" "191" "ENSG00000101444" "AHCY" "A8K307; B3KUN3; E1P5P2; F5H737; hsa:191; P23526; Q96A36" "Folate metabolism; Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Ethanol effects on histone modifications; Spina bifida" "Methylation; Sulfur amino acid metabolism; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Defective AHCY causes HMAHCHD" "11" "2" "1.035" "1.011" "1.041" "0.977" "1.030" "0.996" "0.970" "1.010" "0.784" "10058.9" "10407.2" "10167.7" "10473.4" "9832.6" "10358.0" "10020.4" "9752.7" "10162.9" "7882.3" "" "" "" "" "" "" "" "" "" "" "9044.0" "8421.1" "9197.0" "10223.5" "8114.0" "10358.0" "7503.1" "8614.2" "9093.6" "2813.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6452221919959736930" "False" "High" "IsMasterProtein" "O75122" "CLIP-associating protein 2 OS=Homo sapiens OX=9606 GN=CLASP2 PE=1 SV=3" "0.000" "False" "167.232" "33" "37" "61" "31" "1294" "141.0" "8.40" "221.56" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf12348, Pf21040" "23122" "ENSG00000163539" "CLASP2" "B2RTR1; F5H604; hsa:23122; O75122; Q7L8F6; Q8N6R6; Q9BQT3; Q9BQT4; Q9H7A3; Q9NSZ2" "7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Role of ABL in ROBO-SLIT signaling" "8" "4" "1.010" "0.935" "0.979" "1.012" "0.968" "1.024" "0.946" "0.904" "0.927" "5039.4" "5089.7" "4711.7" "4934.7" "5098.6" "4880.5" "5158.8" "4764.9" "4554.8" "4673.4" "" "" "" "" "" "" "" "" "" "" "4530.9" "4118.4" "4261.9" "4817.0" "4207.5" "4880.5" "3862.8" "4208.7" "4075.6" "1668.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8479889696518381262" "False" "High" "IsMasterProtein" "P37802" "Transgelin-2 OS=Homo sapiens OX=9606 GN=TAGLN2 PE=1 SV=3" "0.000" "False" "166.873" "91" "19" "158" "18" "199" "22.4" "8.25" "538.07" "19" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00307, Pf00402" "8407" "ENSG00000158710" "TAGLN2" "E9KL39; hsa:8407; P37802; Q5JRQ6; Q5JRQ7; Q6FGI1; Q9BUH5; Q9H4P0" "" "Platelet degranulation" "1" "3" "0.959" "0.943" "0.995" "0.970" "1.004" "0.953" "1.035" "0.961" "0.844" "15186.7" "14566.3" "14327.1" "15115.8" "14734.1" "15246.7" "14480.5" "15711.3" "14587.4" "12817.8" "" "" "" "" "" "" "" "" "" "" "13654.3" "11786.5" "12959.3" "14755.1" "12158.8" "15246.7" "10842.7" "13877.3" "13052.7" "4575.6" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1477701677307109055" "False" "High" "IsMasterProtein" "P27694" "Replication protein A 70 kDa DNA-binding subunit OS=Homo sapiens OX=9606 GN=RPA1 PE=1 SV=2" "0.000" "False" "166.814" "49" "29" "69" "29" "616" "68.1" "7.21" "288.33" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01336, Pf04057, Pf08646, Pf16900" "6117" "ENSG00000132383" "RPA1" "A8K0Y9; hsa:6117; P27694; Q59ES9" "Homologous recombination; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "SUMOylation of DNA damage response and repair proteins; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.130" "1.181" "1.057" "1.119" "1.141" "1.015" "1.104" "1.230" "1.059" "7791.7" "8806.0" "9198.3" "8238.3" "8719.9" "8890.8" "7908.1" "8599.3" "9582.8" "8252.2" "" "" "" "" "" "" "" "" "" "" "7005.5" "7125.5" "8320.2" "8041.8" "7195.9" "8890.8" "5921.4" "7595.4" "8574.6" "2945.8" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785579833791404998" "False" "High" "IsMasterProtein" "P17980" "26S proteasome regulatory subunit 6A OS=Homo sapiens OX=9606 GN=PSMC3 PE=1 SV=3" "0.000" "False" "166.668" "65" "23" "73" "23" "439" "49.2" "5.24" "268.37" "23" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5702" "ENSG00000165916" "PSMC3" "B2R8V1; hsa:5702; P17980; Q3B757; Q3B865; Q53HU5; Q6GPG8; Q6IBS1; Q96HD3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; UCH proteinases; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.017" "1.028" "1.011" "0.966" "0.968" "0.976" "0.997" "1.032" "0.915" "7195.3" "7320.9" "7393.5" "7277.5" "6952.8" "6961.7" "7025.9" "7174.8" "7428.6" "6581.1" "" "" "" "" "" "" "" "" "" "" "6469.3" "5923.8" "6687.6" "7103.9" "5737.6" "6961.7" "5260.8" "6337.3" "6647.0" "2349.3" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1534536598926653536" "False" "High" "IsMasterProtein" "P05198" "Eukaryotic translation initiation factor 2 subunit 1 OS=Homo sapiens OX=9606 GN=EIF2S1 PE=1 SV=3" "0.000" "False" "166.647" "67" "21" "82" "21" "315" "36.1" "5.08" "306.81" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf00575, Pf07541" "1965" "ENSG00000134001" "EIF2S1" "hsa:1965; P05198" "Translation factors; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebola virus infection in host; Nonalcoholic fatty liver disease; Measles virus infection; Unfolded protein response; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Alzheimer's disease" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "21" "0" "0.994" "1.026" "0.978" "0.979" "1.004" "0.971" "0.951" "1.014" "0.831" "6288.5" "6251.7" "6455.0" "6147.4" "6158.1" "6314.1" "6108.1" "5979.4" "6376.9" "5224.0" "" "" "" "" "" "" "" "" "" "" "5654.0" "5058.6" "5838.8" "6000.7" "5081.7" "6314.1" "4573.6" "5281.4" "5706.0" "1864.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1479790111935506116" "False" "High" "IsMasterProtein" "Q9P258" "Protein RCC2 OS=Homo sapiens OX=9606 GN=RCC2 PE=1 SV=2" "0.000" "False" "166.073" "64" "32" "81" "32" "522" "56.0" "8.78" "307.10" "32" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00415" "55920" "ENSG00000179051; ENSG00000281540" "RCC2" "hsa:55920; Q8IVL9; Q9BSN6; Q9NPV8; Q9P258" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.027" "0.980" "1.117" "0.967" "1.031" "0.979" "0.992" "0.990" "0.788" "7498.0" "7698.1" "7346.1" "8377.4" "7248.9" "7727.6" "7339.9" "7435.9" "7426.7" "5911.8" "" "" "" "" "" "" "" "" "" "" "6741.4" "6229.1" "6644.8" "8177.5" "5981.9" "7727.6" "5495.9" "6567.8" "6645.3" "2110.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405603430523799899" "False" "High" "IsMasterProtein" "P52888" "Thimet oligopeptidase OS=Homo sapiens OX=9606 GN=THOP1 PE=1 SV=2" "0.000" "False" "165.754" "48" "33" "84" "33" "689" "78.8" "6.05" "301.51" "33" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01432" "7064" "ENSG00000172009" "THOP1" "B3KSE2; hsa:7064; P52888; Q9UCB3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.031" "1.020" "1.012" "1.022" "1.042" "1.008" "1.045" "1.028" "0.832" "10268.2" "10586.6" "10468.8" "10394.0" "10497.1" "10699.0" "10347.1" "10728.9" "10557.6" "8546.1" "" "" "" "" "" "" "" "" "" "" "9232.1" "8566.3" "9469.4" "10146.0" "8662.4" "10699.0" "7747.6" "9476.5" "9446.9" "3050.7" "36" "36" "36" "36" "36" "36" "36" "36" "36" "36" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1721823371863977969" "False" "High" "IsMasterProtein" "Q92973" "Transportin-1 OS=Homo sapiens OX=9606 GN=TNPO1 PE=1 SV=2" "0.000" "False" "165.703" "35" "26" "68" "19" "898" "102.3" "4.98" "267.25" "26" "transport" "cytosol;nucleus;other cell component" "other molecular function" "Pf02985, Pf03810, Pf13513" "3842" "ENSG00000083312" "TNPO1" "B4DVC6; hsa:3842; Q92957; Q92973; Q92975" "22q11.2 copy number variation syndrome" "Postmitotic nuclear pore complex (NPC) reformation; Intraflagellar transport; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA" "4" "6" "1.068" "1.015" "1.018" "1.054" "1.013" "1.056" "1.044" "1.040" "1.152" "6758.0" "7220.3" "6857.0" "6882.6" "7125.7" "6848.8" "7138.4" "7054.1" "7031.6" "7784.1" "" "" "" "" "" "" "" "" "" "" "6076.1" "5842.4" "6202.4" "6718.4" "5880.2" "6848.8" "5345.0" "6230.7" "6291.9" "2778.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6739542972395274555" "False" "High" "IsMasterProtein" "Q9P265" "Disco-interacting protein 2 homolog B OS=Homo sapiens OX=9606 GN=DIP2B PE=1 SV=3" "0.000" "False" "165.585" "29" "39" "55" "39" "1576" "171.4" "8.09" "220.68" "39" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf00501, Pf06464" "57609" "ENSG00000066084" "DIP2B" "hsa:57609; Q6B011; Q8N1L5; Q8NB38; Q9P265" "" "" "0" "0" "1.033" "0.994" "0.970" "1.044" "1.007" "1.012" "1.011" "0.997" "0.840" "3701.4" "3825.4" "3680.8" "3589.6" "3864.1" "3725.8" "3747.2" "3742.7" "3690.9" "3107.5" "" "" "" "" "" "" "" "" "" "" "3328.0" "3095.4" "3329.4" "3503.9" "3188.7" "3725.8" "2805.8" "3305.8" "3302.5" "1109.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6441918618070782743" "False" "High" "IsMasterProtein" "P51610" "Host cell factor 1 OS=Homo sapiens OX=9606 GN=HCFC1 PE=1 SV=2" "0.000" "False" "165.300" "20" "33" "54" "33" "2035" "208.6" "7.46" "216.98" "33" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01344, Pf13415, Pf13854" "3054" "ENSG00000172534" "HCFC1" "hsa:3054; P51610; Q6P4G5" "Mitochondrial gene expression; Pleural mesothelioma" "UCH proteinases; Formation of WDR5-containing histone-modifying complexes; Transcriptional activation of mitochondrial biogenesis; HATs acetylate histones" "6" "0" "0.976" "0.968" "1.009" "0.973" "0.972" "0.991" "0.980" "0.959" "0.938" "5287.8" "5161.4" "5118.3" "5335.1" "5146.8" "5137.8" "5238.0" "5179.4" "5073.2" "4961.6" "" "" "" "" "" "" "" "" "" "" "4754.3" "4176.4" "4629.7" "5207.8" "4247.3" "5137.8" "3922.1" "4574.8" "4539.5" "1771.1" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5095696648215945885" "False" "High" "IsMasterProtein" "P09972" "Fructose-bisphosphate aldolase C OS=Homo sapiens OX=9606 GN=ALDOC PE=1 SV=2" "0.000" "False" "165.055" "67" "23" "94" "15" "364" "39.4" "6.87" "426.60" "23" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00274" "230" "ENSG00000109107" "ALDOC" "B2R5R3; hsa:230; P09972; Q3SYL3; Q6FH94; Q6P0L5" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis; Neutrophil degranulation" "6" "1" "1.038" "1.023" "1.020" "1.036" "1.047" "1.038" "0.997" "1.050" "0.815" "4517.2" "4689.5" "4622.9" "4608.7" "4680.8" "4729.7" "4689.5" "4503.5" "4744.2" "3683.5" "" "" "" "" "" "" "" "" "" "" "4061.4" "3794.6" "4181.6" "4498.8" "3862.7" "4729.7" "3511.4" "3977.8" "4245.1" "1314.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7303961078788059209" "False" "High" "IsMasterProtein" "P49792" "E3 SUMO-protein ligase RanBP2 OS=Homo sapiens OX=9606 GN=RANBP2 PE=1 SV=2" "0.000" "False" "164.884" "17" "47" "56" "37" "3224" "358.0" "6.20" "196.43" "47" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00160, Pf00638, Pf00641, Pf12185" "5903" "ENSG00000153201" "RANBP2" "hsa:5903; P49792; Q13074; Q15280; Q53TE2; Q59FH7" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; tRNA processing in the nucleus; Separation of Sister Chromatids; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Rev-mediated nuclear export of HIV RNA; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Signaling by ALK fusions and activated point mutants" "35" "8" "1.040" "1.020" "1.045" "1.030" "1.024" "1.137" "0.946" "0.972" "3.054" "5034.8" "5236.4" "5136.0" "5262.8" "5186.9" "5153.9" "5725.5" "4763.9" "4892.2" "15377.2" "" "" "" "" "" "" "" "" "" "" "4526.8" "4237.1" "4645.7" "5137.2" "4280.3" "5153.9" "4287.1" "4207.8" "4377.5" "5489.2" "38" "38" "38" "38" "38" "38" "38" "38" "38" "38" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657262686538344528" "False" "High" "IsMasterProtein" "O75717" "WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1" "0.000" "False" "164.784" "35" "36" "48" "36" "1129" "125.9" "5.62" "193.12" "36" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12341, Pf12894, Pf20946" "11169" "ENSG00000198554" "WDHD1" "C9JW18; F6W0U7; hsa:11169; O75717" "Mesodermal commitment pathway" "" "1" "0" "1.022" "1.091" "1.017" "1.028" "1.084" "1.006" "1.017" "1.104" "1.354" "4000.5" "4090.4" "4365.2" "4068.5" "4114.0" "4335.6" "4024.7" "4069.1" "4415.1" "5415.4" "" "" "" "" "" "" "" "" "" "" "3596.9" "3309.8" "3948.5" "3971.4" "3394.9" "4335.6" "3013.6" "3594.1" "3950.6" "1933.1" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6973941838255417452" "False" "High" "IsMasterProtein" "P56192" "Methionine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=MARS1 PE=1 SV=2" "0.000" "False" "164.656" "39" "28" "56" "28" "900" "101.1" "6.16" "218.83" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00043, Pf00458, Pf09334, Pf18485, Pf19303" "4141" "ENSG00000166986" "MARS1" "B3KVK7; hsa:4141; P56192; Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "1.011" "1.037" "1.054" "0.951" "0.996" "1.017" "0.950" "1.085" "2.830" "3348.5" "3384.0" "3472.2" "3528.0" "3184.2" "3333.5" "3406.9" "3180.7" "3633.7" "9475.2" "" "" "" "" "" "" "" "" "" "" "3010.6" "2738.2" "3140.7" "3443.8" "2627.6" "3333.5" "2551.0" "2809.4" "3251.4" "3382.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2986049448252169894" "False" "High" "IsMasterProtein" "Q8N3U4" "Cohesin subunit SA-2 OS=Homo sapiens OX=9606 GN=STAG2 PE=1 SV=3" "0.000" "False" "164.621" "33" "35" "69" "27" "1231" "141.2" "5.43" "219.99" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10735" "ENSG00000101972" "STAG2" "B1AMT5; D3DTF5; hsa:10735; O00540; Q5JTI6; Q68DE9; Q8N3U4; Q9H1N8" "Cell cycle; Cohesin complex - Cornelia de Lange syndrome" "Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Separation of Sister Chromatids; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "9" "6" "1.048" "1.042" "0.974" "1.080" "1.041" "1.003" "1.005" "1.052" "0.858" "4208.1" "4408.6" "4386.1" "4100.7" "4545.6" "4380.7" "4222.7" "4228.6" "4426.4" "3610.7" "" "" "" "" "" "" "" "" "" "" "3783.5" "3567.3" "3967.4" "4002.8" "3751.1" "4380.7" "3161.8" "3735.0" "3960.7" "1288.9" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591250137459754120" "False" "High" "IsMasterProtein" "O43252" "Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 OS=Homo sapiens OX=9606 GN=PAPSS1 PE=1 SV=2" "0.000" "False" "164.525" "52" "24" "59" "24" "624" "70.8" "6.86" "248.11" "24" "other metabolic processes;developmental processes" "cytosol" "kinase activity;other molecular function" "Pf01583, Pf01747, Pf14306" "9061" "ENSG00000138801" "PAPSS1" "hsa:9061; O43252; O43841; O75332; Q6IAX6; Q96FB1; Q96TF4; Q9P1P9; Q9UE98" "Sulfation biotransformation reaction" "Signaling by BRAF and RAF1 fusions; Transport and synthesis of PAPS; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se" "4" "0" "0.998" "1.012" "0.995" "1.009" "0.991" "0.988" "0.989" "1.022" "0.814" "4308.6" "4300.3" "4359.3" "4287.7" "4345.6" "4267.8" "4258.2" "4262.6" "4404.0" "3505.9" "" "" "" "" "" "" "" "" "" "" "3873.8" "3479.7" "3943.1" "4185.4" "3586.1" "4267.8" "3188.4" "3765.0" "3940.7" "1251.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174842833444890787" "False" "High" "IsMasterProtein" "Q99613" "Eukaryotic translation initiation factor 3 subunit C OS=Homo sapiens OX=9606 GN=EIF3C PE=1 SV=1" "0.000" "False" "164.318" "39" "32" "59" "31" "913" "105.3" "5.68" "230.02" "32" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf01399, Pf05470" "8663" "ENSG00000184110" "EIF3C" "A8K7Z0; B2RXG3; B4E1D5; H3BRV0; hsa:8663; O00215; Q99613; Q9BW98" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "1" "1.019" "1.018" "0.935" "0.967" "1.033" "1.000" "0.931" "0.975" "1.704" "5047.1" "5143.4" "5137.1" "4721.0" "4882.6" "5216.0" "5044.7" "4697.1" "4920.5" "8600.1" "" "" "" "" "" "" "" "" "" "" "4537.8" "4161.9" "4646.6" "4608.3" "4029.2" "5216.0" "3777.4" "4148.8" "4402.8" "3070.0" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6148920523022948324" "False" "High" "IsMasterProtein" "P35606" "Coatomer subunit beta' OS=Homo sapiens OX=9606 GN=COPB2 PE=1 SV=2" "0.000" "False" "164.157" "41" "32" "62" "32" "906" "102.4" "5.27" "232.13" "32" "transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00400, Pf04053" "9276" "ENSG00000184432" "COPB2" "B4DZI8; hsa:9276; P35606" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "1.006" "0.993" "0.981" "1.008" "0.953" "0.998" "0.975" "1.013" "0.805" "5388.3" "5422.6" "5351.0" "5284.3" "5430.3" "5132.7" "5379.7" "5255.6" "5457.3" "4334.9" "" "" "" "" "" "" "" "" "" "" "4844.6" "4387.8" "4840.2" "5158.2" "4481.2" "5132.7" "4028.2" "4642.1" "4883.1" "1547.5" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3583580330514197896" "False" "High" "IsMasterProtein" "P55809" "Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=OXCT1 PE=1 SV=1" "0.000" "False" "163.697" "56" "23" "75" "23" "520" "56.1" "7.46" "262.18" "23" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01144" "5019" "ENSG00000083720" "OXCT1" "B2R5V2; B7Z528; hsa:5019; P55809" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies" "2" "0" "0.985" "0.974" "0.998" "0.977" "1.003" "0.971" "1.001" "0.991" "0.751" "6057.0" "5963.7" "5898.8" "6044.0" "5915.6" "6077.5" "5880.3" "6065.6" "6000.3" "4547.5" "" "" "" "" "" "" "" "" "" "" "5445.8" "4825.6" "5335.6" "5899.8" "4881.7" "6077.5" "4403.0" "5357.5" "5369.0" "1623.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9142633453092605073" "False" "High" "IsMasterProtein" "Cont_P63103" "14-3-3 protein zeta/delta OS=Bos taurus OX=9913 GN=YWHAZ PE=1 SV=1" "0.000" "True" "163.481" "73" "21" "221" "15" "245" "27.7" "4.79" "740.47" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00244" "100030704; 100056060; 100127113; 100173609; 100411134; 100484483; 100596460; 100672224; 100727182; 100913480; 100977477; 101012101; 101021050; 101151099; 101331119; 101351914; 101384625; 101687663; 101721954; 101968271; 102019696; 102115184; 102175223; 102283808; 102742022; 102765675; 103004481; 103085559; 103121925; 103191924; 103261347; 103732836; 105005492; 105302907; 105476048; 105504209; 105542098; 105586543; 105719669; 105869900; 106847839; 107142838; 107512228; 109277999; 109382800; 109568481; 109697135; 287022; 472830; 475864; 709723; 7534; 780440" "ENSAMEG00000000328; ENSANAG00000027160; ENSBGRG00000009704; ENSBIXG00000019500; ENSBIXG00005001276; ENSBMSG00010017904; ENSBTAG00000000236; ENSCAFG00000000580; ENSCAFG00845028920; ENSCANG00000043345; ENSCATG00000024186; ENSCCAG00000037757; ENSCCNG00000015730; ENSCHIG00000020223; ENSCJAG00000015844; ENSCLAG00000004303; ENSCPOG00000040522; ENSCWAG00000015721; ENSDLEG00000002530; ENSEASG00005002806; ENSECAG00000021882; ENSFCAG00000037073; ENSG00000164924; ENSGGOG00000022133; ENSHGLG00100048437; ENSLAFG00000004944; ENSMFAG00000001740; ENSMICG00000034946; ENSMLEG00000033187; ENSMMMG00000016188; ENSMMNG00015011551; ENSMMSG00000002669; ENSMMUG00000006489; ENSMNEG00000041365; ENSMODG00000006158; ENSMPUG00000015158; ENSNGAG00000006289; ENSNLEG00000030006; ENSPANG00000010317; ENSPANG00000042694; ENSPEMG00000021714; ENSPPAG00000038734; ENSPPYG00000018791; ENSPSMG00000012736; ENSPSNG00000018640; ENSPTEG00000005862; ENSPTIG00000021410; ENSPTRG00000048115; ENSRFEG00010019368; ENSSBOG00000021820; ENSSDAG00000019504; ENSSHAG00000012671; ENSSSCG00000006062; ENSSSCG00015031811; ENSSSCG00025071491; ENSSSCG00035013965; ENSSSCG00045030109; ENSSSCG00050034502; ENSSSCG00055001784; ENSSSCG00060049326; ENSSSCG00070011887; ENSSSUG00005013206; ENSSTOG00000023864; ENSSVLG00005003330; ENSTSYG00000026493; ENSTTRG00000015906; ENSUAMG00000024432; ENSUMAG00000017568; ENSVURG00010007014; ENSVVUG00000013173" "LOC101351914; LOC111146608; Ywhaz; YWHAZ" "A0A096NQ71; A0A097C2Z1; A0A1D5QAJ7; A0A1S3ABR1; A0A1U7TL92; A0A250XWX3; A0A286XIL7; A0A2I2UD77; A0A2I3GBB0; A0A2J8PMJ1; A0A2J8UFH0; A0A2K5DCH7; A0A2K5KE38; A0A2K5L5H7; A0A2K5SHP3; A0A2K5TVK5; A0A2K5YR93; A0A2K6DL02; A0A2K6SRG4; A0A2R9BQD0; A0A2U3W322; A0A2U3YQG6; A0A2U4AHZ7; A0A2Y9GYG0; A0A2Y9JAB1; A0A2Y9PAR8; A0A2Y9QK13; A0A340XXA5; A0A344MNR9; A0A383ZE89; A0A384BYY2; A0A3Q7NYD6; A0A3Q7S418; A0A452SHE3; A0A480PLY3; A0A4W2CSD8; A0A4X1TV95; A0A4X2KB08; A0A518J2H6; A0A5E4AK25; A0A671FTZ7; A0A673UG86; A0A6B0SHT8; A0A6D2XVW1; A0A6J0W154; A0A6J1ZUX6; A0A6J2B9D9; A0A6J2NBP1; A0A6J3FPA9; A0A6P3J5F7; A0A6P3R2S0; A0A6P5CUI6; A0A6P5ISH5; A0A6P6HS74; A0A7J7TL19; A0A7J7VNU9; A0A7J8C4Y7; A0A7J8DUV8; A0A7N4P7P6; A0A7N5KS25; A0A8B6ZD59; A0A8B7G6A9; A0A8B7RAL2; A0A8B8VLP3; A0A8B9X1D7; A0A8C2UZS6; A0A8C3WSB1; A0A8C4KZ72; A0A8C5ZR25; A0A8C6BH51; A0A8C6CXQ8; A0A8C6QKN2; A0A8C8U9V5; A0A8C8ZIR5; A0A8C9E7Q2; A0A8C9GP54; A0A8C9KQT4; A0A8C9Q7D7; A0A8D2CLR5; A0A8I3Q1P7; A0A8J8XBY4; A0A8J8Y9Q2; A0A8P0S6K0; A0A9V1GJ83; A0A9X9LZ30; A8K1N0; aju:106980045; aml:100484483; B7Z465; bacu:103004481; bbis:105005492; biu:109568481; bom:102283808; bta:287022; cang:105504209; caty:105586543; ccan:109697135; cfa:475864; chx:102175223; cjc:100411134; cpoc:100727182; csyr:103261347; D0PNI1; dle:111180376; elk:111146608; F6XEB4; F7BS95; F7EFF6; F7G9D2; F7HBD4; fca:100127113; G3RS45; G3SV87; G5AP01; G7MZV8; G7PCF6; ggo:101151099; hai:109382800; hgl:101721954; hsa:7534; I3N206; K7DDM2; L5M3G8; lav:100672224; lve:103085559; lww:102742022; M3WVC7; M3YUN9; mcc:709723; mcf:102115184; mdo:100030704; mleu:105542098; mmur:105869900; mni:105476048; mpuf:101687663; myd:102765675; ngi:103732836; nle:100596460; nsu:110579154; oro:101384625; P29213; P29312; P63103; P63104; panu:101012101; panu:101021050; pcoo:112859599; pcw:110196285; pdic:114514896; pon:100173609; pps:100977477; ptg:102966103; ptr:472830; pvp:105302907; Q32P43; Q3ZCF9; Q5R651; Q5XJ08; Q6GPI2; Q6IN74; Q6NUR9; Q6P3U9; Q86V33; ray:107512228; sbq:101047958; shr:100913480; tmu:101351914; U3E3R3; umr:103661509; vvp:112916971; zca:113910054" "Calcium regulation in cardiac cell; Cell cycle; Cell cycle; Prolactin signaling pathway; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; SIDS susceptibility pathways; Pathogenic Escherichia coli infection; Myometrial relaxation and contraction pathways; Hepatitis B infection; GDNF signaling; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways; Calcium regulation in cardiac cells" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Metabolic Genes; Interleukin-3, Interleukin-5 and GM-CSF signaling; Activation of BAD and translocation to mitochondria ; Rap1 signalling; RHO GTPases activate PKNs; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Regulation of localization of FOXO transcription factors; Deactivation of the beta-catenin transactivating complex; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling; Interleukin-3, Interleukin-5 and GM-CSF signaling; NOTCH4 Activation and Transmission of Signal to the Nucleus; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Rap1 signalling; KSRP (KHSRP) binds and destabilizes mRNA; GP1b-IX-V activation signalling" "40" "5" "0.941" "0.945" "1.062" "0.960" "1.028" "0.937" "1.033" "0.974" "0.792" "11046.6" "10396.3" "10440.9" "11735.6" "10607.2" "11359.6" "10355.1" "11416.6" "10758.7" "8750.6" "" "" "" "" "" "" "" "" "" "" "9931.9" "8412.3" "9444.2" "11455.6" "8753.3" "11359.6" "7753.6" "10083.8" "9626.8" "3123.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463755477932393031" "False" "High" "IsMasterProtein" "Q9H4M9" "EH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EHD1 PE=1 SV=2" "0.000" "False" "163.230" "53" "25" "82" "23" "534" "60.6" "6.83" "319.63" "25" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "10938" "ENSG00000110047" "EHD1" "hsa:10938; O14611; Q2M3Q4; Q9H4M9; Q9UNR3" "Insulin signaling" "Factors involved in megakaryocyte development and platelet production" "2" "2" "0.992" "0.966" "1.026" "0.994" "0.989" "0.979" "1.011" "0.976" "0.796" "7339.0" "7280.2" "7087.5" "7527.0" "7296.6" "7261.0" "7185.8" "7419.9" "7159.4" "5838.7" "" "" "" "" "" "" "" "" "" "" "6598.5" "5890.9" "6410.9" "7347.4" "6021.3" "7261.0" "5380.5" "6553.8" "6406.1" "2084.3" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2867565850229162791" "False" "High" "IsMasterProtein" "P12081" "Histidine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=HARS1 PE=1 SV=2" "0.000" "False" "162.487" "50" "27" "67" "20" "509" "57.4" "5.88" "247.57" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00458, Pf03129, Pf13393" "3035" "ENSG00000170445" "HARS1" "B4DHQ1; B4DY73; D6REN6; hsa:3035; J3KNE5; P12081" "Allograft rejection" "Cytosolic tRNA aminoacylation" "2" "6" "1.024" "1.003" "0.996" "1.039" "0.957" "1.003" "1.007" "1.026" "0.805" "6422.3" "6578.1" "6438.8" "6394.7" "6674.1" "6145.0" "6444.8" "6467.6" "6591.3" "5169.8" "" "" "" "" "" "" "" "" "" "" "5774.3" "5322.8" "5824.1" "6242.1" "5507.6" "6145.0" "4825.7" "5712.6" "5897.8" "1845.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6753985911223903494" "False" "High" "IsMasterProtein" "P68032" "Actin, alpha cardiac muscle 1 OS=Homo sapiens OX=9606 GN=ACTC1 PE=1 SV=1" "0.000" "False" "162.292" "46" "20" "782" "3" "377" "42.0" "5.39" "2444.34" "20" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "70" "ENSG00000159251" "ACTC1" "hsa:70; P04270; P68032" "Cardiac progenitor differentiation; Myometrial relaxation and contraction pathways; Striated muscle contraction pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; 22q11.2 copy number variation syndrome; Pleural mesothelioma" "RHOA GTPase cycle; RHOB GTPase cycle; Striated Muscle Contraction" "9" "0" "0.986" "1.048" "1.026" "1.021" "1.015" "0.982" "1.031" "1.055" "0.924" "9295.6" "9162.3" "9739.7" "9540.3" "9495.1" "9439.4" "9125.3" "9586.3" "9804.2" "8587.5" "" "" "" "" "" "" "" "" "" "" "8357.7" "7413.8" "8809.9" "9312.7" "7835.6" "9439.4" "6832.8" "8467.3" "8772.7" "3065.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6019619507196981202" "False" "High" "IsMasterProtein" "P61158" "Actin-related protein 3 OS=Homo sapiens OX=9606 GN=ACTR3 PE=1 SV=3" "0.000" "False" "162.233" "56" "23" "100" "19" "418" "47.3" "5.88" "391.17" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10096" "ENSG00000115091" "ACTR3" "hsa:10096; P32391; P61158; Q53QM2" "Physico-chemical features and toxicity-associated pathways" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "5" "1.034" "1.020" "1.044" "1.012" "1.052" "1.002" "1.046" "1.044" "0.818" "9945.1" "10279.2" "10146.1" "10381.3" "10065.6" "10460.2" "9964.1" "10401.7" "10385.4" "8134.6" "" "" "" "" "" "" "" "" "" "" "8941.6" "8317.6" "9177.5" "10133.6" "8306.3" "10460.2" "7460.9" "9187.4" "9292.8" "2903.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5359713146649655482" "False" "High" "IsMasterProtein" "P31150" "Rab GDP dissociation inhibitor alpha OS=Homo sapiens OX=9606 GN=GDI1 PE=1 SV=2" "0.000" "False" "162.225" "58" "21" "77" "12" "447" "50.6" "5.14" "293.47" "21" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "2664" "ENSG00000203879" "GDI1" "hsa:2664; P31150; P50394; Q6FG50; Q7Z2G6; Q7Z2G9; Q7Z2H5; Q7Z2I6" "Ciliary landscape; Airway smooth muscle cell contraction" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "1.016" "1.061" "0.995" "1.014" "0.970" "0.991" "0.983" "1.049" "0.808" "3447.4" "3502.5" "3656.9" "3430.9" "3496.5" "3343.3" "3417.7" "3389.7" "3615.2" "2784.2" "" "" "" "" "" "" "" "" "" "" "3099.6" "2834.1" "3307.8" "3349.1" "2885.4" "3343.3" "2559.1" "2994.0" "3234.9" "993.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792882720935006206" "False" "High" "IsMasterProtein" "Q9HAV4" "Exportin-5 OS=Homo sapiens OX=9606 GN=XPO5 PE=1 SV=1" "0.000" "False" "161.958" "29" "31" "64" "31" "1204" "136.2" "5.80" "231.26" "31" "RNA metabolism OR transcription;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03810, Pf08389, Pf19273" "57510" "ENSG00000124571" "XPO5" "hsa:57510; Q5JTE6; Q96G48; Q96HN3; Q9BWM6; Q9BZV5; Q9H9M4; Q9HAV4; Q9NT89; Q9NW39; Q9ULC9" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Primary ovarian insufficiency" "MicroRNA (miRNA) biogenesis" "4" "0" "1.149" "1.150" "0.990" "1.119" "1.070" "1.063" "1.074" "1.126" "1.024" "4958.3" "5696.6" "5703.8" "4910.6" "5550.3" "5305.5" "5271.0" "5326.2" "5581.7" "5075.9" "" "" "" "" "" "" "" "" "" "" "4458.0" "4609.5" "5159.3" "4793.5" "4580.2" "5305.5" "3946.8" "4704.5" "4994.5" "1811.9" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5310524526174993710" "False" "High" "IsMasterProtein" "P51003" "Poly(A) polymerase alpha OS=Homo sapiens OX=9606 GN=PAPOLA PE=1 SV=4" "0.000" "False" "161.877" "51" "29" "63" "26" "745" "82.8" "7.37" "244.83" "29" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "10914" "ENSG00000090060" "PAPOLA" "hsa:10914; P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "2" "1.021" "1.018" "0.972" "1.005" "0.986" "1.006" "1.007" "1.018" "0.839" "4360.6" "4450.4" "4440.2" "4240.2" "4383.6" "4300.1" "4385.2" "4391.2" "4440.5" "3656.6" "" "" "" "" "" "" "" "" "" "" "3920.6" "3601.1" "4016.3" "4139.0" "3617.4" "4300.1" "3283.6" "3878.6" "3973.4" "1305.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866201622056559647" "False" "High" "IsMasterProtein" "Q13263" "Transcription intermediary factor 1-beta OS=Homo sapiens OX=9606 GN=TRIM28 PE=1 SV=5" "0.000" "False" "161.795" "34" "26" "67" "26" "835" "88.5" "5.77" "240.92" "26" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00628, Pf00643, Pf14634" "10155" "ENSG00000130726" "TRIM28" "hsa:10155; O00677; Q13263; Q7Z632; Q93040; Q96IM1" "Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; ATM signaling in development and disease" "Generic Transcription Pathway; HCMV Early Events; SUMOylation of transcription cofactors" "6" "0" "0.989" "1.021" "1.004" "1.023" "0.993" "1.029" "0.997" "1.008" "1.938" "5347.7" "5291.1" "5460.1" "5368.1" "5469.0" "5309.5" "5504.3" "5334.2" "5389.6" "10363.4" "" "" "" "" "" "" "" "" "" "" "4808.1" "4281.4" "4938.8" "5240.0" "4513.1" "5309.5" "4121.5" "4711.5" "4822.6" "3699.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7904029165854268952" "False" "High" "IsMasterProtein" "P62191" "26S proteasome regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMC1 PE=1 SV=1" "0.000" "False" "161.776" "62" "26" "72" "24" "440" "49.2" "6.21" "262.90" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5700" "ENSG00000100764" "PSMC1" "B4DR63; hsa:5700; P49014; P62191; Q03527; Q6IAW0; Q6NW36; Q96AZ3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "64" "0" "1.005" "0.985" "0.975" "0.974" "0.979" "1.016" "0.991" "0.977" "0.969" "4852.8" "4875.1" "4779.1" "4733.6" "4725.7" "4751.0" "4930.2" "4810.1" "4742.5" "4703.0" "" "" "" "" "" "" "" "" "" "" "4363.2" "3944.8" "4322.9" "4620.7" "3899.7" "4751.0" "3691.6" "4248.6" "4243.6" "1678.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7881821209807726399" "False" "High" "IsMasterProtein" "O75153" "Clustered mitochondria protein homolog OS=Homo sapiens OX=9606 GN=CLUH PE=1 SV=2" "0.000" "False" "161.761" "40" "43" "58" "43" "1309" "146.6" "6.13" "209.50" "43" "cell organization and biogenesis" "other cell component" "nucleic acid binding activity" "Pf12807, Pf13236, Pf13374, Pf13424, Pf15044" "23277" "ENSG00000132361" "CLUH" "hsa:23277; O75153; Q6AHY2; Q6P3X7; Q6ZUG8; Q8N4U7; Q9BTA3; Q9H979" "Translation factors" "" "1" "0" "0.980" "1.027" "0.954" "0.967" "0.976" "1.014" "0.907" "0.967" "1.339" "3362.2" "3296.5" "3451.8" "3209.1" "3250.6" "3280.1" "3409.3" "3050.1" "3252.4" "4502.2" "" "" "" "" "" "" "" "" "" "" "3022.9" "2667.4" "3122.2" "3132.5" "2682.5" "3280.1" "2552.8" "2694.0" "2910.2" "1607.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5217508454541550081" "False" "High" "IsMasterProtein" "P50453" "Serpin B9 OS=Homo sapiens OX=9606 GN=SERPINB9 PE=1 SV=1" "0.000" "False" "161.628" "63" "23" "81" "22" "376" "42.4" "5.86" "317.16" "23" "other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00079" "5272" "ENSG00000170542" "SERPINB9" "B2RBW3; hsa:5272; P50453; Q5TD03" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "1" "1.025" "1.033" "1.046" "1.018" "0.981" "1.030" "1.016" "1.018" "0.745" "7648.6" "7838.0" "7903.8" "7998.6" "7784.1" "7503.0" "7877.1" "7768.2" "7787.3" "5699.2" "" "" "" "" "" "" "" "" "" "" "6876.9" "6342.2" "7149.2" "7807.8" "6423.6" "7503.0" "5898.2" "6861.4" "6968.1" "2034.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1304014562382960910" "False" "High" "IsMasterProtein" "O60216" "Double-strand-break repair protein rad21 homolog OS=Homo sapiens OX=9606 GN=RAD21 PE=1 SV=2" "0.000" "False" "161.042" "50" "25" "57" "24" "631" "71.6" "4.65" "239.35" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04824, Pf04825" "5885" "ENSG00000164754" "RAD21" "A8K0E0; hsa:5885; O60216; Q15001; Q99568" "Cell cycle; Prion disease pathway; Regulation of sister chromatid separation at the metaphase-anaphase transition; Cohesin complex - Cornelia de Lange syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Estrogen-dependent gene expression; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "13" "1" "1.025" "1.037" "1.007" "1.037" "1.043" "1.046" "1.073" "1.060" "0.863" "4546.8" "4659.2" "4714.5" "4577.3" "4715.1" "4743.3" "4754.8" "4876.8" "4818.8" "3924.2" "" "" "" "" "" "" "" "" "" "" "4088.1" "3770.1" "4264.4" "4468.1" "3891.0" "4743.3" "3560.2" "4307.5" "4311.8" "1400.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7644877244443849971" "False" "High" "IsMasterProtein" "Q13177" "Serine/threonine-protein kinase PAK 2 OS=Homo sapiens OX=9606 GN=PAK2 PE=1 SV=3" "0.000" "False" "160.913" "47" "20" "94" "15" "524" "58.0" "5.96" "336.44" "20" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5062" "ENSG00000180370" "PAK2" "hsa:5062; Q13154; Q13177; Q6ISC3" "Integrin-mediated cell adhesion; Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Fas ligand pathway and stress induction of heat shock proteins; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 3q29 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway" "FCERI mediated MAPK activation; Regulation of activated PAK-2p34 by proteasome mediated degradation; MAPK6/MAPK4 signaling; RHOU GTPase cycle; Sema3A PAK dependent Axon repulsion; Generation of second messenger molecules; Regulation of PAK-2p34 activity by PS-GAP/RHG10; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Ephrin signaling; Smooth Muscle Contraction; RHO GTPases activate PAKs; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway; Nef and signal transduction; Stimulation of the cell death response by PAK-2p34" "45" "6" "0.976" "0.985" "1.015" "0.977" "0.963" "0.964" "1.010" "0.971" "0.795" "10188.1" "9941.5" "10037.7" "10344.4" "9951.2" "9810.3" "9817.5" "10293.9" "9891.9" "8097.2" "" "" "" "" "" "" "" "" "" "" "9160.1" "8044.3" "9079.4" "10097.6" "8211.9" "9810.3" "7351.1" "9092.2" "8851.2" "2890.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "626595147841982495" "False" "High" "IsMasterProtein" "Q92835" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2" "0.000" "False" "160.598" "38" "39" "56" "38" "1189" "133.2" "7.59" "217.38" "39" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00017" "3635" "ENSG00000168918; ENSG00000281614" "INPP5D" "hsa:3635; O00145; Q13544; Q13545; Q6P5A4; Q92656; Q92835; Q9UE80" "B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway; Netrin-UNC5B signaling pathway; 5q35 copy number variation" "Downstream TCR signaling; Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Synthesis of IP3 and IP4 in the cytosol; PECAM1 interactions" "13" "1" "1.054" "1.051" "1.015" "1.059" "1.050" "1.068" "0.956" "1.040" "3.333" "4031.7" "4249.2" "4237.9" "4093.0" "4268.0" "4234.3" "4304.9" "3855.1" "4192.3" "13438.9" "" "" "" "" "" "" "" "" "" "" "3624.9" "3438.3" "3833.3" "3995.3" "3522.0" "4234.3" "3223.4" "3405.0" "3751.2" "4797.3" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2641060010654775307" "False" "High" "IsMasterProtein" "O00232" "26S proteasome non-ATPase regulatory subunit 12 OS=Homo sapiens OX=9606 GN=PSMD12 PE=1 SV=3" "0.000" "False" "160.483" "54" "22" "71" "22" "456" "52.9" "7.65" "251.81" "22" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf18098" "5718" "ENSG00000197170" "PSMD12" "A6NP15; hsa:5718; O00232; Q53HA2; Q6P053" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.011" "1.004" "0.981" "0.989" "0.953" "1.007" "1.020" "0.995" "0.846" "5557.5" "5618.3" "5580.8" "5450.0" "5498.7" "5297.0" "5598.5" "5666.1" "5532.5" "4703.8" "" "" "" "" "" "" "" "" "" "" "4996.8" "4546.2" "5048.1" "5320.0" "4537.6" "5297.0" "4192.0" "5004.6" "4950.4" "1679.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074215629290594570" "False" "High" "IsMasterProtein" "P22626" "Heterogeneous nuclear ribonucleoproteins A2/B1 OS=Homo sapiens OX=9606 GN=HNRNPA2B1 PE=1 SV=2" "0.000" "False" "160.028" "65" "26" "168" "22" "353" "37.4" "8.95" "562.65" "26" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3181" "ENSG00000122566" "HNRNPA2B1" "A0A024RA27; A0A024RA61; A8K064; hsa:3181; P22626; P22627; Q9UC98; Q9UDJ2" "mRNA processing" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "2" "0.985" "0.938" "1.034" "0.982" "0.971" "1.002" "1.009" "0.928" "0.881" "10931.6" "10772.2" "10249.7" "11301.7" "10735.6" "10610.5" "10949.5" "11027.2" "10140.9" "9630.7" "" "" "" "" "" "" "" "" "" "" "9828.6" "8716.5" "9271.2" "11032.1" "8859.3" "10610.5" "8198.7" "9739.9" "9074.0" "3437.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1079834079423301401" "False" "High" "IsMasterProtein" "Q8TD19" "Serine/threonine-protein kinase Nek9 OS=Homo sapiens OX=9606 GN=NEK9 PE=1 SV=2" "0.000" "False" "159.949" "35" "30" "50" "30" "979" "107.1" "5.74" "204.87" "30" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00415, Pf13540" "91754" "ENSG00000119638" "NEK9" "hsa:91754; Q52LK6; Q8NCN0; Q8TCY4; Q8TD19; Q9UPI4; Q9Y6S4; Q9Y6S5; Q9Y6S6" "Ciliopathies" "EML4 and NUDC in mitotic spindle formation; Nuclear Pore Complex (NPC) Disassembly; Activation of NIMA Kinases NEK9, NEK6, NEK7" "4" "0" "1.011" "1.014" "0.986" "0.989" "0.970" "0.974" "0.974" "1.029" "0.917" "4456.5" "4507.0" "4518.7" "4395.6" "4405.9" "4324.5" "4338.8" "4339.4" "4584.5" "4087.7" "" "" "" "" "" "" "" "" "" "" "4006.9" "3646.9" "4087.3" "4290.7" "3635.8" "4324.5" "3248.8" "3832.8" "4102.1" "1459.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3353104297975983136" "False" "High" "IsMasterProtein" "O43242" "26S proteasome non-ATPase regulatory subunit 3 OS=Homo sapiens OX=9606 GN=PSMD3 PE=1 SV=2" "0.000" "False" "159.015" "63" "33" "73" "33" "534" "60.9" "8.44" "251.71" "33" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf08375" "5709" "ENSG00000108344" "PSMD3" "B3KMW9; B4DT72; hsa:5709; O43242; Q96EI2; Q9BQA4" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.024" "1.023" "1.029" "0.993" "0.964" "1.015" "0.977" "1.030" "0.836" "6723.9" "6884.4" "6876.2" "6920.7" "6675.3" "6481.5" "6823.9" "6566.4" "6925.4" "5622.9" "" "" "" "" "" "" "" "" "" "" "6045.4" "5570.6" "6219.8" "6755.6" "5508.6" "6481.5" "5109.5" "5799.9" "6196.8" "2007.2" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2657182436335150623" "False" "High" "IsMasterProtein" "Q9Y3I0" "RNA-splicing ligase RtcB homolog OS=Homo sapiens OX=9606 GN=RTCB PE=1 SV=1" "0.000" "False" "158.993" "54" "25" "68" "25" "505" "55.2" "7.23" "250.07" "25" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01139" "51493" "ENSG00000100220" "RTCB" "B2R6A8; hsa:51493; Q6IAI0; Q9BWL4; Q9NTH1; Q9P037; Q9P0J3; Q9Y3I0" "Unfolded protein response" "tRNA processing in the nucleus" "2" "0" "0.999" "1.031" "0.996" "1.003" "1.019" "0.975" "0.986" "1.010" "0.847" "6803.3" "6799.7" "7016.0" "6772.8" "6822.2" "6930.1" "6632.9" "6709.5" "6871.2" "5759.4" "" "" "" "" "" "" "" "" "" "" "6116.8" "5502.1" "6346.2" "6611.2" "5629.8" "6930.1" "4966.5" "5926.2" "6148.3" "2056.0" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2123612860387903516" "False" "High" "IsMasterProtein" "P08243" "Asparagine synthetase [glutamine-hydrolyzing] OS=Homo sapiens OX=9606 GN=ASNS PE=1 SV=4" "0.000" "False" "158.978" "50" "24" "74" "24" "561" "64.3" "6.86" "266.51" "24" "other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00733, Pf13537" "440" "ENSG00000070669" "ASNS" "A4D1I8; B4DXZ1; B7ZAA9; D6W5R3; E9PCI3; E9PCX6; hsa:440; P08184; P08243; Q15666; Q549T9; Q96HD0" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Aspartate and asparagine metabolism; Response of EIF2AK1 (HRI) to heme deficiency; ATF4 activates genes in response to endoplasmic reticulum stress; Response of EIF2AK4 (GCN2) to amino acid deficiency" "6" "0" "0.970" "0.996" "0.969" "0.973" "0.951" "0.944" "0.961" "1.024" "0.746" "6747.7" "6544.6" "6720.0" "6540.7" "6563.3" "6414.6" "6371.3" "6484.5" "6910.0" "5033.0" "" "" "" "" "" "" "" "" "" "" "6066.9" "5295.6" "6078.5" "6384.7" "5416.2" "6414.6" "4770.6" "5727.5" "6183.0" "1796.6" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5526079506929447963" "False" "High" "IsMasterProtein" "O14617" "AP-3 complex subunit delta-1 OS=Homo sapiens OX=9606 GN=AP3D1 PE=1 SV=1" "0.000" "False" "158.791" "30" "33" "57" "33" "1153" "130.1" "8.48" "212.45" "33" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01602, Pf06375" "8943" "ENSG00000065000" "AP3D1" "O00202; O14617; O75262; Q59HF5; Q96G11; Q9H3C6" "" "" "0" "0" "1.025" "0.994" "0.999" "0.995" "0.979" "1.025" "1.012" "1.011" "0.935" "3197.0" "3276.1" "3176.9" "3192.4" "3181.2" "3128.5" "3278.4" "3236.6" "3231.6" "2988.4" "" "" "" "" "" "" "" "" "" "" "2874.4" "2650.9" "2873.6" "3116.2" "2625.2" "3128.5" "2454.8" "2858.8" "2891.6" "1066.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656401588938308742" "False" "High" "IsMasterProtein" "Q14676" "Mediator of DNA damage checkpoint protein 1 OS=Homo sapiens OX=9606 GN=MDC1 PE=1 SV=3" "0.000" "False" "158.779" "23" "35" "54" "35" "2089" "226.5" "5.47" "207.55" "35" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00498, Pf16589, Pf16770" "9656" "ENSG00000137337; ENSG00000206481; ENSG00000224587; ENSG00000225589; ENSG00000228575; ENSG00000231135; ENSG00000234012; ENSG00000237095" "MDC1" "A2AB04; A2BF04; A2RRA8; A7YY86; B0S8A2; hsa:9656; Q0EFC2; Q14676; Q2L6H7; Q2TAZ4; Q5JP55; Q5JP56; Q5ST83; Q68CQ3; Q86Z06; Q96QC2" "ATM signaling in development and disease ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "9" "0" "0.959" "0.861" "0.918" "0.939" "0.996" "0.956" "0.870" "0.766" "0.680" "3348.6" "3212.4" "2883.6" "3074.7" "3145.6" "3333.7" "3200.8" "2912.4" "2564.2" "2276.1" "" "" "" "" "" "" "" "" "" "" "3010.7" "2599.4" "2608.3" "3001.4" "2595.8" "3333.7" "2396.6" "2572.4" "2294.4" "812.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4155367153969888648" "False" "High" "IsMasterProtein" "Cont_P13645" "Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6" "0.000" "True" "158.206" "55" "29" "56" "24" "584" "58.8" "5.21" "227.94" "29" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038" "3858" "ENSG00000186395" "KRT10" "hsa:3858; P13645; Q14664; Q8N175" "" "Formation of the cornified envelope" "2" "5" "0.597" "1.146" "1.028" "0.606" "2.519" "1.170" "1.349" "0.696" "2.484" "4383.6" "2617.6" "5023.1" "4505.9" "2654.9" "11042.2" "5127.0" "5915.4" "3050.5" "10889.9" "" "" "" "" "" "" "" "" "" "" "3941.3" "2118.1" "4543.6" "4398.3" "2190.9" "11042.2" "3839.0" "5224.9" "2729.5" "3887.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5836622772794954890" "False" "High" "IsMasterProtein" "P06400" "Retinoblastoma-associated protein OS=Homo sapiens OX=9606 GN=RB1 PE=1 SV=2" "0.000" "False" "158.137" "33" "30" "82" "30" "928" "106.1" "7.94" "274.66" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf08934, Pf11934" "5925" "ENSG00000139687" "RB1" "A8K5E3; hsa:5925; P06400; P78499; Q5VW46; Q8IZL4" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Adipogenesis; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Bladder cancer; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Effect of progerin on genes involved in progeria; Ciliary landscape; G1 to S cell cycle control; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sphingolipid metabolism in senescence; Prostaglandin and leukotriene metabolism in senescence ; ID signaling pathway; TROP2 regulatory signaling; Prostaglandin and leukotriene metabolism in senescence ; 8q11.23 (RB1CC1) copy number variation; Omega-6-fatty acids in senescence; DNA damage response" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Aberrant regulation of mitotic exit in cancer due to RB1 defects; RUNX2 regulates osteoblast differentiation; Condensation of Prophase Chromosomes; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; Cyclin A:Cdk2-associated events at S phase entry; Formation of Senescence-Associated Heterochromatin Foci (SAHF); Inhibition of replication initiation of damaged DNA by RB1/E2F1; Defective translocation of RB1 mutants to the nucleus; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome; Nuclear events stimulated by ALK signaling in cancer" "51" "0" "1.015" "1.061" "0.983" "1.011" "1.021" "1.005" "1.017" "1.051" "0.913" "7823.4" "7941.4" "8297.6" "7687.7" "7905.8" "7991.5" "7864.2" "7959.8" "8219.7" "7144.8" "" "" "" "" "" "" "" "" "" "" "7034.0" "6425.9" "7505.5" "7504.3" "6524.0" "7991.5" "5888.5" "7030.7" "7354.9" "2550.5" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7883409800749118824" "False" "High" "IsMasterProtein" "Q7KZ85" "Transcription elongation factor SPT6 OS=Homo sapiens OX=9606 GN=SUPT6H PE=1 SV=2" "0.000" "False" "157.805" "26" "36" "53" "36" "1726" "198.9" "4.91" "201.11" "36" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00575, Pf14632, Pf14633, Pf14635, Pf14639, Pf14641, Pf17674" "6830" "ENSG00000109111" "SUPT6H" "A7E2B4; hsa:6830; Q15737; Q6GMQ4; Q7KYW9; Q7KZ85; Q7LDK4; Q8N526; Q92775; Q96AH3; Q9BTH9; Q9BTI2" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "0.975" "1.025" "0.954" "0.997" "1.019" "0.960" "0.976" "1.062" "1.180" "3582.3" "3492.9" "3670.8" "3417.0" "3573.2" "3648.8" "3439.8" "3496.8" "3806.2" "4228.1" "" "" "" "" "" "" "" "" "" "" "3220.8" "2826.3" "3320.4" "3335.5" "2948.7" "3648.8" "2575.6" "3088.6" "3405.7" "1509.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273803465605434037" "False" "High" "IsMasterProtein" "P05455" "Lupus La protein OS=Homo sapiens OX=9606 GN=SSB PE=1 SV=2" "0.000" "False" "157.611" "62" "27" "97" "27" "408" "46.8" "7.12" "323.84" "27" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "6741" "ENSG00000138385" "SSB" "hsa:6741; P05455; Q15367; Q53XJ4" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "1.004" "0.922" "1.002" "0.996" "0.942" "0.995" "1.055" "0.884" "0.976" "11162.5" "11207.7" "10295.0" "11185.1" "11118.4" "10516.0" "11107.5" "11779.7" "9862.9" "10896.8" "" "" "" "" "" "" "" "" "" "" "10036.2" "9068.8" "9312.2" "10918.2" "9175.1" "10516.0" "8317.0" "10404.6" "8825.2" "3889.8" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7946497630754715310" "False" "High" "IsMasterProtein" "Q9H223" "EH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=EHD4 PE=1 SV=1" "0.000" "False" "157.594" "45" "21" "61" "19" "541" "61.1" "6.76" "230.98" "21" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00350, Pf12763, Pf16880, Pf18150" "30844" "ENSG00000103966" "EHD4" "hsa:30844; Q9H223; Q9HAR1; Q9NZN2" "" "" "0" "0" "1.041" "1.039" "1.031" "1.066" "1.020" "1.037" "1.066" "1.057" "0.942" "5049.2" "5257.1" "5247.1" "5203.2" "5380.7" "5150.4" "5237.0" "5382.9" "5337.9" "4758.7" "" "" "" "" "" "" "" "" "" "" "4539.7" "4253.8" "4746.2" "5079.1" "4440.2" "5150.4" "3921.3" "4754.5" "4776.3" "1698.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3565723958770546681" "False" "High" "IsMasterProtein" "Q08378" "Golgin subfamily A member 3 OS=Homo sapiens OX=9606 GN=GOLGA3 PE=1 SV=2" "0.000" "False" "157.506" "30" "38" "52" "38" "1498" "167.3" "5.44" "210.71" "38" "" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "2802" "ENSG00000090615" "GOLGA3" "A5PKX6; hsa:2802; O43241; Q08378; Q6P9C7; Q86XW3; Q8TDA9; Q8WZA3" "" "RND2 GTPase cycle" "1" "0" "0.996" "1.003" "1.001" "1.045" "1.042" "1.049" "1.032" "0.989" "1.017" "4086.2" "4068.8" "4100.3" "4088.5" "4271.6" "4257.4" "4285.8" "4217.4" "4040.5" "4155.2" "" "" "" "" "" "" "" "" "" "" "3673.9" "3292.3" "3708.9" "3991.0" "3525.0" "4257.4" "3209.1" "3725.1" "3615.4" "1483.3" "33" "33" "33" "33" "33" "33" "33" "33" "33" "33" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5288684708523747991" "False" "High" "IsMasterProtein" "Q14240" "Eukaryotic initiation factor 4A-II OS=Homo sapiens OX=9606 GN=EIF4A2 PE=1 SV=2" "0.000" "False" "157.417" "52" "23" "104" "11" "407" "46.4" "5.48" "389.19" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1974" "ENSG00000156976" "EIF4A2" "D3DNU9; hsa:1974; Q14240; Q53XJ6; Q96B90; Q96EA8" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Translation initiation complex formation; Ribosomal scanning and start codon recognition; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "1.039" "1.032" "1.013" "1.034" "1.020" "1.034" "1.002" "1.057" "0.791" "3563.6" "3703.5" "3676.6" "3610.1" "3684.3" "3635.7" "3684.9" "3571.3" "3768.2" "2818.8" "" "" "" "" "" "" "" "" "" "" "3204.1" "2996.8" "3325.6" "3523.9" "3040.4" "3635.7" "2759.2" "3154.4" "3371.8" "1006.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394918450034897638" "False" "High" "IsMasterProtein" "P55884" "Eukaryotic translation initiation factor 3 subunit B OS=Homo sapiens OX=9606 GN=EIF3B PE=1 SV=3" "0.000" "False" "157.331" "34" "25" "73" "25" "814" "92.4" "5.00" "263.04" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08662" "8662" "ENSG00000106263" "EIF3B" "A4D208; hsa:8662; P55884; Q2NL77; Q9UMF9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.025" "1.056" "1.004" "0.963" "1.057" "1.003" "0.938" "1.068" "1.606" "6277.8" "6434.4" "6626.4" "6304.4" "6046.4" "6636.4" "6294.7" "5886.6" "6707.0" "10080.0" "" "" "" "" "" "" "" "" "" "" "5644.4" "5206.5" "5993.8" "6153.9" "4989.6" "6636.4" "4713.3" "5199.4" "6001.4" "3598.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834517730795482410" "False" "High" "IsMasterProtein" "Q05655" "Protein kinase C delta type OS=Homo sapiens OX=9606 GN=PRKCD PE=1 SV=2" "0.000" "False" "157.325" "44" "28" "61" "27" "676" "77.5" "7.75" "211.13" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf21494" "5580" "ENSG00000163932" "PRKCD" "B0KZ81; B2R834; hsa:5580; Q05655; Q15144; Q86XJ6" "Type II diabetes mellitus; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; IL6 signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Wnt signaling pathway and pluripotency; Pancreatic adenocarcinoma pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Galanin receptor pathway; Orexin receptor pathway; CCL18 signaling pathway; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Calcium regulation in cardiac cells; Type II interferon signaling; T-cell receptor signaling pathway" "CLEC7A (Dectin-1) signaling; KEAP1-NFE2L2 pathway; Neutrophil degranulation; Interferon gamma signaling; VEGFR2 mediated cell proliferation; Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; HuR (ELAVL1) binds and stabilizes mRNA; DAG and IP3 signaling; Effects of PIP2 hydrolysis; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; Apoptotic cleavage of cellular proteins" "47" "0" "1.008" "0.985" "1.028" "0.982" "0.929" "0.984" "1.001" "0.975" "0.951" "4819.2" "4858.0" "4748.4" "4954.9" "4733.4" "4476.8" "4743.4" "4825.9" "4699.2" "4581.8" "" "" "" "" "" "" "" "" "" "" "4333.0" "3930.9" "4295.1" "4836.7" "3906.0" "4476.8" "3551.7" "4262.5" "4204.8" "1635.6" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3080832168399393297" "False" "High" "IsMasterProtein" "Q9Y6D6" "Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens OX=9606 GN=ARFGEF1 PE=1 SV=2" "0.000" "False" "157.178" "25" "41" "53" "30" "1849" "208.6" "5.85" "184.70" "41" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10565" "ENSG00000066777" "ARFGEF1" "hsa:10565; Q9NV46; Q9UFV2; Q9UNL0; Q9Y6D6" "" "" "0" "9" "1.008" "0.984" "0.913" "1.015" "0.960" "1.011" "0.994" "0.969" "1.057" "3463.3" "3490.2" "3406.1" "3161.4" "3516.4" "3323.7" "3502.2" "3443.4" "3354.8" "3662.4" "" "" "" "" "" "" "" "" "" "" "3113.8" "2824.1" "3081.0" "3086.0" "2901.8" "3323.7" "2622.4" "3041.5" "3001.8" "1307.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523949865199722082" "False" "High" "IsMasterProtein" "P50579" "Methionine aminopeptidase 2 OS=Homo sapiens OX=9606 GN=METAP2 PE=1 SV=1" "0.000" "False" "156.795" "51" "22" "94" "22" "478" "52.9" "5.82" "364.90" "22" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00557" "10988" "ENSG00000111142" "METAP2" "B2RDI8; B4DUX5; G3XA91; hsa:10988; P50579; Q8NB11" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.148" "1.043" "1.067" "1.042" "1.156" "1.024" "1.118" "1.042" "0.843" "6113.5" "7018.0" "6375.8" "6521.2" "6372.3" "7064.6" "6258.8" "6836.6" "6369.4" "5153.0" "" "" "" "" "" "" "" "" "" "" "5496.7" "5678.7" "5767.1" "6365.6" "5258.6" "7064.6" "4686.5" "6038.5" "5699.3" "1839.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781846477469752128" "False" "High" "IsMasterProtein" "P38606" "V-type proton ATPase catalytic subunit A OS=Homo sapiens OX=9606 GN=ATP6V1A PE=1 SV=2" "0.000" "False" "156.782" "45" "24" "77" "24" "617" "68.3" "5.52" "267.50" "24" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874, Pf16886" "523" "ENSG00000114573" "ATP6V1A" "B2RBR8; B7Z1R5; D3DN75; hsa:523; P38606; Q53YD9; Q96DY6; Q9UHY3" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.040" "1.004" "0.985" "1.013" "0.967" "1.011" "0.985" "1.020" "0.827" "6948.0" "7222.8" "6978.2" "6842.0" "7037.3" "6719.0" "7021.9" "6842.0" "7085.6" "5746.1" "" "" "" "" "" "" "" "" "" "" "6246.9" "5844.5" "6312.0" "6678.7" "5807.3" "6719.0" "5257.8" "6043.3" "6340.2" "2051.2" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5272993671693515484" "False" "High" "IsMasterProtein" "Q15181" "Inorganic pyrophosphatase OS=Homo sapiens OX=9606 GN=PPA1 PE=1 SV=2" "0.000" "False" "156.354" "79" "19" "87" "18" "289" "32.6" "5.86" "339.00" "19" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00719" "5464" "ENSG00000180817" "PPA1" "hsa:5464; Q15181; Q2M348; Q5SQT7; Q6P7P4; Q9UQJ5; Q9Y5B1" "" "Cytosolic tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "1" "0.970" "0.947" "1.003" "1.004" "1.007" "0.973" "1.013" "0.992" "0.770" "9189.1" "8910.2" "8699.7" "9213.6" "9230.3" "9252.8" "8940.2" "9304.0" "9111.2" "7077.9" "" "" "" "" "" "" "" "" "" "" "8261.9" "7209.8" "7869.2" "8993.7" "7617.0" "9252.8" "6694.2" "8217.9" "8152.6" "2526.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370453687865171634" "False" "High" "IsMasterProtein" "P39880" "Homeobox protein cut-like 1 OS=Homo sapiens OX=9606 GN=CUX1 PE=1 SV=3" "0.000" "False" "156.010" "29" "38" "48" "38" "1505" "164.1" "5.90" "176.90" "38" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf02376" "1523" "ENSG00000257923" "CUX1" "B3KV79; J3KQV9; P39880; Q6NYH4; Q75LE5; Q75MT2; Q75MT3; Q86UJ7; Q9UEV5" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.010" "0.982" "1.031" "1.054" "1.015" "1.048" "1.060" "0.999" "1.234" "4982.8" "5031.7" "4892.9" "5135.5" "5251.3" "5058.3" "5224.4" "5279.5" "4976.7" "6150.2" "" "" "" "" "" "" "" "" "" "" "4480.0" "4071.5" "4425.8" "5012.9" "4333.5" "5058.3" "3911.9" "4663.2" "4453.1" "2195.4" "34" "34" "34" "34" "34" "34" "34" "34" "34" "34" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7479442399663165637" "False" "High" "IsMasterProtein" "Cont_P02769" "Albumin OS=Bos taurus OX=9913 GN=ALB PE=1 SV=4" "0.000" "True" "155.961" "59" "34" "51" "34" "607" "69.2" "6.18" "190.80" "34" "stress response;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity;other molecular function" "Pf00273" "280717" "" "ALB" "A5PJX3; bta:280717; O02787; P02769; P04277; Q3SZR2" "" "" "0" "0" "1.123" "0.947" "1.194" "1.352" "0.996" "1.069" "1.224" "0.923" "0.886" "4577.1" "5138.9" "4332.3" "5463.2" "6187.0" "4560.8" "4891.1" "5604.0" "4223.7" "4053.0" "" "" "" "" "" "" "" "" "" "" "4115.3" "4158.2" "3918.7" "5332.9" "5105.7" "4560.8" "3662.4" "4949.8" "3779.3" "1446.8" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "397277040626667291" "False" "High" "IsMasterProtein" "Q9UBB4" "Ataxin-10 OS=Homo sapiens OX=9606 GN=ATXN10 PE=1 SV=1" "0.000" "False" "155.757" "46" "21" "70" "21" "475" "53.5" "5.25" "263.48" "21" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf09759" "25814" "ENSG00000130638" "ATXN10" "A6NLC4; B4DG05; hsa:25814; O14998; O15009; Q6I9X4; Q9UBB4" "Ciliopathies" "" "1" "0" "1.018" "1.011" "0.983" "1.026" "0.993" "1.045" "1.033" "1.004" "0.877" "5159.8" "5253.1" "5216.7" "5070.8" "5292.6" "5123.7" "5392.9" "5328.1" "5179.2" "4527.5" "" "" "" "" "" "" "" "" "" "" "4639.1" "4250.6" "4718.6" "4949.8" "4367.5" "5123.7" "4038.0" "4706.1" "4634.3" "1616.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-109273256828227415" "False" "High" "IsMasterProtein" "Q07866" "Kinesin light chain 1 OS=Homo sapiens OX=9606 GN=KLC1 PE=1 SV=2" "0.000" "False" "155.703" "54" "30" "56" "22" "573" "65.3" "6.20" "197.03" "30" "cell adhesion;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00515, Pf13374, Pf13424" "3831" "ENSG00000126214" "KLC1" "A6NF62; F8VTM4; hsa:3831; Q07866; Q7RTM2; Q7RTM3; Q7RTM5; Q7RTP9; Q7RTQ3; Q7RTQ5; Q7RTQ6; Q86SF5; Q86TF5; Q86V74; Q86V75; Q86V76; Q86V77; Q86V78; Q86V79; Q96H62" "Alzheimer's disease and miRNA effects; IL-18 signaling pathway; Alzheimer's disease" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "8" "7" "0.946" "0.957" "0.974" "0.993" "0.938" "0.966" "0.998" "0.959" "0.816" "4681.9" "4428.2" "4481.3" "4559.7" "4649.9" "4389.5" "4524.4" "4672.8" "4488.6" "3822.3" "" "" "" "" "" "" "" "" "" "" "4209.5" "3583.1" "4053.5" "4450.9" "3837.2" "4389.5" "3387.8" "4127.3" "4016.4" "1364.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6634363274650926044" "False" "High" "IsMasterProtein" "Q14839" "Chromodomain-helicase-DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=CHD4 PE=1 SV=2" "0.000" "False" "155.429" "24" "42" "58" "42" "1912" "217.9" "5.86" "203.17" "42" "cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf00628, Pf06461, Pf06465, Pf08073, Pf08074" "1108" "ENSG00000111642" "CHD4" "Q14839; Q8IXZ5" "Rett syndrome; Effect of progerin on genes involved in progeria" "RNA Polymerase I Transcription Initiation; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation; NGF-stimulated transcription" "9" "0" "1.005" "0.994" "0.930" "0.993" "1.008" "0.979" "0.894" "0.976" "3.518" "3746.5" "3765.4" "3723.3" "3484.4" "3720.4" "3778.2" "3668.4" "3349.0" "3656.9" "13179.0" "" "" "" "" "" "" "" "" "" "" "3368.4" "3046.8" "3367.8" "3401.2" "3070.1" "3778.2" "2746.8" "2958.1" "3272.2" "4704.5" "31" "31" "31" "31" "31" "31" "31" "31" "31" "31" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369524592651400068" "False" "High" "IsMasterProtein" "P43490" "Nicotinamide phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAMPT PE=1 SV=1" "0.000" "False" "155.420" "58" "26" "87" "26" "491" "55.5" "7.15" "321.59" "26" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04095, Pf18127" "10135" "ENSG00000105835" "NAMPT" "A4D0Q9; A4D0R0; hsa:10135; P43490; Q3KQV0; Q8WW95" "Adipogenesis; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Caloric restriction and aging; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "NPAS4 regulates expression of target genes; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nicotinamide salvaging" "9" "0" "0.998" "1.045" "0.990" "1.014" "0.989" "0.977" "1.003" "1.020" "0.816" "9828.0" "9810.7" "10273.7" "9733.4" "9968.0" "9717.9" "9599.7" "9857.6" "10027.1" "8015.7" "" "" "" "" "" "" "" "" "" "" "8836.3" "7938.4" "9292.9" "9501.1" "8225.8" "9717.9" "7188.0" "8706.8" "8972.2" "2861.4" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479686062085054609" "False" "High" "IsMasterProtein" "Q15365" "Poly(rC)-binding protein 1 OS=Homo sapiens OX=9606 GN=PCBP1 PE=1 SV=2" "0.000" "False" "155.222" "68" "16" "116" "10" "356" "37.5" "7.09" "452.38" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5093" "ENSG00000169564" "PCBP1" "hsa:5093; Q13157; Q14975; Q15365" "Ferroptosis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "9" "0.993" "1.039" "0.925" "0.967" "0.924" "0.961" "0.963" "0.927" "1.183" "10577.2" "10501.6" "10985.3" "9788.4" "10223.8" "9771.8" "10159.6" "10187.1" "9805.1" "12516.7" "" "" "" "" "" "" "" "" "" "" "9509.9" "8497.5" "9936.6" "9554.8" "8436.9" "9771.8" "7607.2" "8997.9" "8773.5" "4468.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7589685267009723312" "False" "High" "IsMasterProtein" "Q9H0D6" "5'-3' exoribonuclease 2 OS=Homo sapiens OX=9606 GN=XRN2 PE=1 SV=1" "0.000" "False" "154.647" "36" "31" "61" "31" "950" "108.5" "7.47" "216.76" "31" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846" "22803" "ENSG00000088930" "XRN2" "hsa:22803; Q3L8N4; Q6KGZ9; Q9BQL1; Q9H0D6; Q9NTW0; Q9NXS6; Q9UL53" "mRNA processing" "Major pathway of rRNA processing in the nucleolus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.009" "1.020" "0.988" "1.039" "1.042" "1.041" "1.010" "1.016" "0.993" "4053.3" "4090.1" "4132.4" "4005.7" "4211.1" "4223.3" "4218.0" "4093.7" "4118.4" "4023.7" "" "" "" "" "" "" "" "" "" "" "3644.3" "3309.5" "3737.9" "3910.2" "3475.1" "4223.3" "3158.3" "3615.8" "3685.1" "1436.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4468909642596951639" "False" "High" "IsMasterProtein" "Q15020" "Squamous cell carcinoma antigen recognized by T-cells 3 OS=Homo sapiens OX=9606 GN=SART3 PE=1 SV=1" "0.000" "False" "154.636" "42" "37" "60" "37" "963" "109.9" "5.57" "225.61" "37" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf05391, Pf16605" "9733" "ENSG00000075856" "SART3" "A8K2E4; B7ZKM0; hsa:9733; Q15020; Q2M2H0; Q58F06; Q8IUS1; Q96J95" "" "" "0" "0" "1.027" "0.966" "0.998" "1.004" "0.998" "1.000" "1.010" "0.951" "1.077" "6077.8" "6242.2" "5873.4" "6066.1" "6100.4" "6063.5" "6078.9" "6138.9" "5778.6" "6545.1" "" "" "" "" "" "" "" "" "" "" "5464.5" "5050.9" "5312.7" "5921.4" "5034.1" "6063.5" "4551.7" "5422.3" "5170.7" "2336.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5335677543697524354" "False" "High" "IsMasterProtein" "P17844" "Probable ATP-dependent RNA helicase DDX5 OS=Homo sapiens OX=9606 GN=DDX5 PE=1 SV=1" "0.000" "False" "154.312" "43" "28" "64" "20" "614" "69.1" "8.92" "215.76" "28" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08061" "1655" "ENSG00000108654" "DDX5" "B4DLW8; B5BU21; D3DU32; E7ETL9; hsa:1655; O75681; P17844; Q53Y61" "Ciliary landscape" "mRNA Splicing - Major Pathway; SUMOylation of transcription cofactors; Estrogen-dependent gene expression; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "6" "0" "0.995" "0.948" "0.930" "0.955" "1.070" "0.924" "0.926" "0.914" "0.903" "4293.2" "4270.2" "4070.2" "3991.7" "4101.5" "4592.9" "3967.8" "3974.0" "3924.6" "3877.9" "" "" "" "" "" "" "" "" "" "" "3860.1" "3455.3" "3681.6" "3896.5" "3384.6" "4592.9" "2971.0" "3510.1" "3511.7" "1384.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3779865839115366179" "False" "High" "IsMasterProtein" "P00367" "Glutamate dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=GLUD1 PE=1 SV=2" "0.000" "False" "154.308" "45" "23" "63" "23" "558" "61.4" "7.80" "233.32" "23" "other metabolic processes;other biological processes" "mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00208, Pf02812" "2746" "ENSG00000148672" "GLUD1" "B3KV55; B4DGN5; hsa:2746; P00367; Q5TBU3" "VEGFA-VEGFR2 signaling; Amino acid metabolism; Metabolic reprogramming in colon cancer; 22q11.2 copy number variation syndrome; Amino acid metabolism pathway excerpt: histidine catabolism extension; 10q22q23 copy number variation" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; Glutamate and glutamine metabolism" "9" "0" "0.969" "0.986" "0.996" "0.949" "0.986" "0.952" "0.976" "0.986" "0.779" "6827.7" "6614.0" "6734.4" "6799.7" "6482.8" "6729.9" "6501.5" "6662.1" "6732.8" "5319.3" "" "" "" "" "" "" "" "" "" "" "6138.7" "5351.8" "6091.5" "6637.5" "5349.8" "6729.9" "4868.2" "5884.4" "6024.5" "1898.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1799847195195984928" "False" "High" "IsMasterProtein" "Q5VYK3" "Proteasome adapter and scaffold protein ECM29 OS=Homo sapiens OX=9606 GN=ECPAS PE=1 SV=2" "0.000" "False" "153.787" "27" "41" "49" "41" "1845" "204.2" "7.12" "182.20" "41" "cell organization and biogenesis" "cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12755, Pf13001" "23392" "ENSG00000136813" "ECPAS" "A0A804HJA4; B3KXF2; O15074; Q5VYK3; Q8WU82" "" "" "0" "0" "0.993" "0.996" "0.978" "1.017" "0.984" "0.998" "0.972" "0.995" "1.013" "3599.6" "3574.0" "3583.7" "3519.9" "3659.2" "3541.4" "3592.3" "3499.9" "3580.7" "3645.3" "" "" "" "" "" "" "" "" "" "" "3236.4" "2891.9" "3241.6" "3435.9" "3019.6" "3541.4" "2689.8" "3091.3" "3204.0" "1301.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8788439396421035672" "False" "High" "IsMasterProtein" "Q92621" "Nuclear pore complex protein Nup205 OS=Homo sapiens OX=9606 GN=NUP205 PE=1 SV=3" "0.000" "False" "153.632" "22" "39" "58" "39" "2012" "227.8" "6.19" "207.79" "39" "cell organization and biogenesis;transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf11894" "23165" "ENSG00000155561" "NUP205" "A6H8X3; hsa:23165; Q86YC1; Q92621" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.079" "1.125" "0.987" "1.064" "1.080" "1.048" "0.981" "1.121" "1.314" "5734.8" "6187.0" "6448.9" "5658.3" "6100.4" "6195.8" "6011.1" "5626.9" "6427.6" "7536.7" "" "" "" "" "" "" "" "" "" "" "5156.2" "5006.3" "5833.2" "5523.3" "5034.2" "6195.8" "4501.0" "4970.0" "5751.4" "2690.4" "32" "32" "32" "32" "32" "32" "32" "32" "32" "32" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028691531671689044" "False" "High" "IsMasterProtein" "Q14697" "Neutral alpha-glucosidase AB OS=Homo sapiens OX=9606 GN=GANAB PE=1 SV=3" "0.000" "False" "153.361" "35" "28" "68" "28" "944" "106.8" "6.14" "272.06" "28" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf01055, Pf13802, Pf21365" "23193" "ENSG00000089597" "GANAB" "A6NC20; hsa:23193; Q14697; Q8WTS9; Q9P0X0" "N-glycan biosynthesis" "Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "5" "0" "0.965" "0.975" "1.004" "0.973" "0.943" "1.013" "0.922" "0.937" "1.054" "6217.6" "6000.6" "6060.3" "6244.8" "6050.7" "5863.7" "6301.1" "5731.8" "5826.4" "6552.8" "" "" "" "" "" "" "" "" "" "" "5590.3" "4855.4" "5481.7" "6095.8" "4993.1" "5863.7" "4718.1" "5062.7" "5213.4" "2339.2" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2399497510241032173" "False" "High" "IsMasterProtein" "P25705" "ATP synthase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1A PE=1 SV=1" "0.000" "False" "153.044" "52" "26" "62" "26" "553" "59.7" "9.13" "228.57" "26" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00006, Pf00306, Pf02874" "498" "ENSG00000152234" "ATP5F1A" "A8K092; B4DY56; hsa:498; K7ENP3; P25705; Q53XX6; Q8IXV2; Q96FB4; Q96HW2; Q96IR6; Q9BTV8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein import; Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "7" "0" "1.114" "1.105" "0.972" "1.068" "1.146" "1.066" "1.067" "1.150" "0.914" "5562.0" "6194.2" "6145.4" "5408.9" "5940.3" "6375.8" "5931.0" "5934.6" "6393.6" "5080.9" "" "" "" "" "" "" "" "" "" "" "5000.7" "5012.1" "5558.7" "5279.9" "4902.0" "6375.8" "4441.0" "5241.9" "5720.9" "1813.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6919500497101416540" "False" "High" "IsMasterProtein" "Q9UJU6" "Drebrin-like protein OS=Homo sapiens OX=9606 GN=DBNL PE=1 SV=1" "0.000" "False" "152.864" "46" "18" "66" "18" "430" "48.2" "5.05" "271.05" "18" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241, Pf14604" "28988" "ENSG00000136279" "DBNL" "A4D2I9; B4DDP6; B4DEM2; C9J7P1; hsa:28988; P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; Q9UJU6" "T-cell receptor signaling pathway" "Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins; Neurexins and neuroligins" "4" "0" "0.983" "0.972" "0.987" "0.974" "1.005" "0.963" "1.009" "0.965" "0.971" "5283.8" "5192.0" "5136.6" "5213.8" "5146.5" "5309.0" "5088.4" "5330.1" "5099.4" "5130.8" "" "" "" "" "" "" "" "" "" "" "4750.6" "4201.1" "4646.2" "5089.4" "4247.0" "5309.0" "3810.1" "4707.9" "4562.9" "1831.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7590147556392166876" "False" "High" "IsMasterProtein" "P07384" "Calpain-1 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN1 PE=1 SV=1" "0.000" "False" "152.754" "43" "28" "64" "28" "714" "81.8" "5.67" "228.46" "28" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00648, Pf01067, Pf13833" "823" "ENSG00000014216" "CAPN1" "P07384; Q2TTR0; Q6DHV4" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Formation of the cornified envelope; Degradation of the extracellular matrix; Neutrophil degranulation; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "7" "0" "1.078" "1.027" "1.002" "1.022" "0.989" "1.003" "1.018" "1.054" "0.843" "4636.6" "4997.9" "4760.5" "4646.6" "4738.3" "4584.6" "4649.9" "4720.8" "4887.5" "3910.2" "" "" "" "" "" "" "" "" "" "" "4168.8" "4044.2" "4306.0" "4535.7" "3910.1" "4584.6" "3481.7" "4169.7" "4373.3" "1395.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1351774447437735542" "False" "High" "IsMasterProtein" "Q9NQW7" "Xaa-Pro aminopeptidase 1 OS=Homo sapiens OX=9606 GN=XPNPEP1 PE=1 SV=3" "0.000" "False" "152.565" "49" "26" "55" "25" "623" "69.9" "5.67" "215.52" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf01321, Pf16188, Pf16189" "7511" "ENSG00000108039" "XPNPEP1" "A8K071; G5E9Y2; G8JLB2; hsa:7511; O15250; Q53EX6; Q8N3Q0; Q96D23; Q9NQW7" "" "" "0" "0" "0.955" "0.951" "1.013" "0.955" "0.940" "0.981" "0.936" "0.935" "0.913" "5202.3" "4968.1" "4945.8" "5268.3" "4970.5" "4892.8" "5105.2" "4869.0" "4865.4" "4751.4" "" "" "" "" "" "" "" "" "" "" "4677.4" "4020.0" "4473.6" "5142.6" "4101.7" "4892.8" "3822.6" "4300.6" "4353.6" "1696.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-719373628240286726" "False" "High" "IsMasterProtein" "O00231" "26S proteasome non-ATPase regulatory subunit 11 OS=Homo sapiens OX=9606 GN=PSMD11 PE=1 SV=3" "0.000" "False" "151.895" "61" "24" "76" "24" "422" "47.4" "6.48" "334.48" "24" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399, Pf18055, Pf18503" "5717" "ENSG00000108671" "PSMD11" "A8K3I7; E1P663; hsa:5717; O00231; O00495; Q53FT5" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.032" "1.034" "1.042" "1.025" "1.002" "1.046" "1.070" "1.057" "0.896" "9655.8" "9960.0" "9985.6" "10057.2" "9896.7" "9678.3" "10095.6" "10333.9" "10206.7" "8652.5" "" "" "" "" "" "" "" "" "" "" "8681.5" "8059.3" "9032.3" "9817.2" "8166.9" "9678.3" "7559.3" "9127.6" "9132.9" "3088.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7001879318500673012" "False" "High" "IsMasterProtein" "P11940" "Polyadenylate-binding protein 1 OS=Homo sapiens OX=9606 GN=PABPC1 PE=1 SV=2" "0.000" "False" "151.849" "36" "23" "107" "16" "636" "70.6" "9.50" "349.89" "23" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "26986" "ENSG00000070756" "PABPC1" "hsa:26986; P11940; Q15097; Q93004" "Translation factors; Endoderm differentiation; VEGFA-VEGFR2 signaling; Acute viral myocarditis" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; AUF1 (hnRNP D0) binds and destabilizes mRNA; Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "13" "7" "1.021" "0.976" "1.070" "0.973" "0.970" "0.985" "1.008" "0.976" "0.821" "9591.3" "9788.5" "9365.0" "10258.1" "9337.0" "9306.0" "9449.5" "9669.7" "9360.6" "7872.8" "" "" "" "" "" "" "" "" "" "" "8623.5" "7920.5" "8471.0" "10013.3" "7705.1" "9306.0" "7075.5" "8540.9" "8375.8" "2810.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7129667850847229200" "False" "High" "IsMasterProtein" "P52209" "6-phosphogluconate dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=PGD PE=1 SV=3" "0.000" "False" "151.612" "56" "24" "81" "24" "483" "53.1" "7.23" "305.00" "24" "other metabolic processes" "cytosol" "other molecular function" "Pf00393, Pf03446" "5226" "ENSG00000142657" "PGD" "A8K2Y9; B4DQJ8; hsa:5226; P52209; Q9BWD8" "Pentose phosphate metabolism; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer" "NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "7" "0" "1.008" "1.034" "1.009" "1.016" "1.013" "1.036" "0.991" "1.037" "0.771" "6508.4" "6560.0" "6726.7" "6569.7" "6610.3" "6594.5" "6741.0" "6452.3" "6749.8" "5018.3" "" "" "" "" "" "" "" "" "" "" "5851.7" "5308.1" "6084.5" "6412.9" "5454.9" "6594.5" "5047.5" "5699.1" "6039.6" "1791.4" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5990763445808986334" "False" "High" "IsMasterProtein" "O75083" "WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=WDR1 PE=1 SV=4" "0.000" "False" "151.160" "48" "24" "70" "24" "606" "66.2" "6.65" "298.18" "24" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00400" "9948" "ENSG00000071127" "WDR1" "A8K6E9; A8MPU4; hsa:9948; O75083; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0" "Hypertrophy model" "Platelet degranulation" "2" "0" "1.002" "1.009" "1.033" "0.981" "0.936" "1.004" "0.984" "1.016" "0.796" "7424.6" "7441.1" "7490.6" "7672.9" "7283.9" "6952.8" "7453.4" "7306.2" "7546.4" "5909.8" "" "" "" "" "" "" "" "" "" "" "6675.4" "6021.0" "6775.5" "7489.8" "6010.8" "6952.8" "5580.9" "6453.3" "6752.5" "2109.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5136159273712408888" "False" "High" "IsMasterProtein" "P38919" "Eukaryotic initiation factor 4A-III OS=Homo sapiens OX=9606 GN=EIF4A3 PE=1 SV=4" "0.000" "False" "151.044" "60" "23" "69" "20" "411" "46.8" "6.73" "253.59" "23" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "9775" "ENSG00000141543; ENSG00000291508" "EIF4A3" "hsa:9775; P38919; Q15033; Q6IBQ2; Q96A18" "TAR syndrome" "Regulation of expression of SLITs and ROBOs; Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; ISG15 antiviral mechanism; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "11" "0" "1.030" "1.029" "0.947" "1.043" "0.980" "0.981" "0.969" "1.035" "0.754" "4383.8" "4516.8" "4509.6" "4151.9" "4570.3" "4296.4" "4301.4" "4249.0" "4537.7" "3306.1" "" "" "" "" "" "" "" "" "" "" "3941.5" "3654.8" "4079.1" "4052.9" "3771.5" "4296.4" "3220.8" "3753.0" "4060.3" "1180.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3531814392904203237" "False" "High" "IsMasterProtein" "P09884" "DNA polymerase alpha catalytic subunit OS=Homo sapiens OX=9606 GN=POLA1 PE=1 SV=2" "0.000" "False" "150.815" "28" "34" "51" "34" "1462" "165.8" "5.85" "186.55" "34" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf08996, Pf12254" "5422" "ENSG00000101868" "POLA1" "hsa:5422; P09884; Q86UQ7" "Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; G1/S-Specific Transcription; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "1.002" "1.023" "0.975" "1.005" "1.012" "0.985" "0.972" "1.011" "1.221" "4312.0" "4320.0" "4412.0" "4204.3" "4334.3" "4362.7" "4247.9" "4191.4" "4359.8" "5265.7" "" "" "" "" "" "" "" "" "" "" "3876.9" "3495.6" "3990.8" "4104.0" "3576.7" "4362.7" "3180.7" "3702.1" "3901.2" "1879.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6180366262275080504" "False" "High" "IsMasterProtein" "P00505" "Aspartate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GOT2 PE=1 SV=3" "0.000" "False" "150.594" "50" "23" "100" "23" "430" "47.5" "9.01" "356.12" "23" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00155" "2806" "ENSG00000125166" "GOT2" "B4DJA6; E7ERW2; hsa:2806; P00505; Q53FL3; Q9BWA3" "Alanine and aspartate metabolism; Amino acid metabolism; Metabolic reprogramming in colon cancer; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Gluconeogenesis; Aspartate and asparagine metabolism; Glutamate and glutamine metabolism; Degradation of cysteine and homocysteine" "11" "0" "1.044" "1.020" "1.121" "1.056" "1.000" "1.033" "1.015" "1.034" "0.821" "9755.7" "10188.3" "9946.9" "10934.2" "10299.9" "9758.9" "10081.8" "9903.1" "10090.5" "8009.3" "" "" "" "" "" "" "" "" "" "" "8771.4" "8244.0" "8997.3" "10673.3" "8499.7" "9758.9" "7549.0" "8747.0" "9028.9" "2859.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1757040485264551221" "False" "High" "IsMasterProtein" "Q9Y6A5" "Transforming acidic coiled-coil-containing protein 3 OS=Homo sapiens OX=9606 GN=TACC3 PE=1 SV=1" "0.000" "False" "150.030" "44" "28" "54" "28" "838" "90.3" "5.05" "194.27" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf05010" "10460" "ENSG00000013810" "TACC3" "hsa:10460; Q2NKK4; Q3KQS5; Q9UMQ1; Q9Y6A5" "4p16.3 copy number variation" "NOTCH3 Activation and Transmission of Signal to the Nucleus; Negative regulation of NOTCH4 signaling" "3" "0" "1.017" "1.270" "0.959" "1.020" "1.350" "1.000" "1.021" "1.312" "0.965" "3529.3" "3590.3" "4480.8" "3384.6" "3600.5" "4763.8" "3530.6" "3602.0" "4631.0" "3406.4" "" "" "" "" "" "" "" "" "" "" "3173.2" "2905.1" "4053.0" "3303.9" "2971.2" "4763.8" "2643.6" "3181.5" "4143.8" "1216.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7082716862048425116" "False" "High" "IsMasterProtein" "Q9BPX3" "Condensin complex subunit 3 OS=Homo sapiens OX=9606 GN=NCAPG PE=1 SV=1" "0.000" "False" "149.970" "35" "30" "55" "30" "1015" "114.3" "5.59" "201.46" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12719" "64151" "ENSG00000109805" "NCAPG" "hsa:64151; Q3MJE0; Q96SV9; Q9BPX3; Q9BUR3; Q9BVY1; Q9H914; Q9H9Z6; Q9HBI9" "" "Condensation of Prometaphase Chromosomes" "1" "0" "1.058" "1.053" "0.974" "1.033" "1.013" "1.061" "1.035" "1.045" "1.411" "4095.3" "4331.5" "4310.5" "3989.2" "4232.2" "4149.6" "4345.7" "4240.0" "4280.1" "5778.7" "" "" "" "" "" "" "" "" "" "" "3682.1" "3504.9" "3899.0" "3894.0" "3492.5" "4149.6" "3254.0" "3745.0" "3829.8" "2062.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2411801021050745689" "False" "High" "IsMasterProtein" "Q9NSE4" "Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=IARS2 PE=1 SV=2" "0.000" "False" "149.965" "31" "27" "50" "27" "1012" "113.7" "7.20" "179.80" "27" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00133, Pf06827, Pf08264" "55699" "ENSG00000067704" "IARS2" "B2RPG8; hsa:55699; Q1M2P9; Q6PI85; Q7L439; Q86WU9; Q96D91; Q9H9Q8; Q9NSE4; Q9NW42" "" "Mitochondrial protein degradation; Mitochondrial tRNA aminoacylation" "2" "0" "1.025" "1.011" "1.015" "1.048" "0.995" "1.014" "1.004" "0.989" "0.846" "4011.9" "4112.7" "4056.6" "4073.6" "4202.5" "3991.4" "4067.5" "4027.1" "3966.2" "3392.2" "" "" "" "" "" "" "" "" "" "" "3607.0" "3327.8" "3669.4" "3976.4" "3468.0" "3991.4" "3045.6" "3557.0" "3548.9" "1210.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2386724705728610253" "False" "High" "IsMasterProtein" "Q9UHB6" "LIM domain and actin-binding protein 1 OS=Homo sapiens OX=9606 GN=LIMA1 PE=1 SV=1" "0.000" "False" "149.549" "45" "28" "55" "27" "759" "85.2" "6.84" "219.60" "28" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "51474" "ENSG00000050405" "LIMA1" "B2RB09; hsa:51474; Q2TAN7; Q59FE8; Q9BVF2; Q9H8J1; Q9HBN5; Q9NX96; Q9NXC3; Q9NXU6; Q9P0H8; Q9UHB5; Q9UHB6" "" "" "0" "1" "0.971" "1.024" "1.043" "1.005" "1.059" "1.037" "1.087" "1.118" "0.832" "5074.2" "4927.9" "5193.6" "5291.8" "5098.7" "5373.1" "5264.0" "5517.2" "5675.0" "4220.8" "" "" "" "" "" "" "" "" "" "" "4562.2" "3987.5" "4697.8" "5165.6" "4207.5" "5373.1" "3941.6" "4873.1" "5077.9" "1506.7" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7968684939462891772" "False" "High" "IsMasterProtein" "O14974" "Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens OX=9606 GN=PPP1R12A PE=1 SV=1" "0.000" "False" "149.152" "36" "34" "53" "34" "1030" "115.2" "5.40" "193.82" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf15898" "4659" "ENSG00000058272" "PPP1R12A" "B4DZ09; F8VWB4; hsa:4659; O14974; Q2NKL4; Q569H0; Q86WU3; Q8NFR6; Q9BYH0" "Focal adhesion; Hippo-Merlin signaling dysregulation; Regulation of actin cytoskeleton" "Regulation of PLK1 Activity at G2/M Transition; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "0" "0.967" "1.058" "1.033" "1.004" "1.118" "1.005" "1.007" "1.026" "0.848" "4541.1" "4392.5" "4805.4" "4689.9" "4560.8" "5075.2" "4561.7" "4573.2" "4659.2" "3848.6" "" "" "" "" "" "" "" "" "" "" "4082.9" "3554.2" "4346.7" "4578.0" "3763.6" "5075.2" "3415.7" "4039.4" "4169.0" "1373.8" "29" "29" "29" "29" "29" "29" "29" "29" "29" "29" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6518875519697934580" "False" "High" "IsMasterProtein" "Q92576" "PHD finger protein 3 OS=Homo sapiens OX=9606 GN=PHF3 PE=1 SV=3" "0.000" "False" "149.134" "20" "37" "48" "37" "2039" "229.3" "6.96" "175.55" "37" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00628, Pf07500, Pf07744" "23469" "ENSG00000118482" "PHF3" "A3KFI8; hsa:23469; Q14CR5; Q5CZI1; Q5T1T6; Q92576; Q9NQ16; Q9UI45" "" "" "0" "0" "0.997" "0.951" "0.971" "1.010" "1.018" "1.012" "0.975" "0.953" "0.806" "3745.6" "3733.7" "3561.0" "3638.2" "3784.4" "3812.4" "3791.9" "3650.7" "3570.0" "3019.8" "" "" "" "" "" "" "" "" "" "" "3367.6" "3021.1" "3221.0" "3551.4" "3123.0" "3812.4" "2839.3" "3224.5" "3194.4" "1078.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-996241339141020167" "False" "High" "IsMasterProtein" "Q96SB8" "Structural maintenance of chromosomes protein 6 OS=Homo sapiens OX=9606 GN=SMC6 PE=1 SV=2" "0.000" "False" "149.084" "38" "38" "52" "38" "1091" "126.2" "6.99" "178.03" "38" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13476" "79677" "ENSG00000163029" "SMC6" "A8K8Q6; D6W518; hsa:79677; Q05BV4; Q96SB8; Q9H0X3; Q9H6M0" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "1.017" "0.969" "1.008" "1.007" "0.984" "0.989" "0.983" "0.986" "0.887" "3160.4" "3213.6" "3063.4" "3185.4" "3182.5" "3108.9" "3125.6" "3107.6" "3116.0" "2803.7" "" "" "" "" "" "" "" "" "" "" "2841.5" "2600.3" "2770.9" "3109.4" "2626.2" "3108.9" "2340.4" "2744.8" "2788.2" "1000.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4317219429199659424" "False" "High" "IsMasterProtein" "Q9H6Z4" "Ran-binding protein 3 OS=Homo sapiens OX=9606 GN=RANBP3 PE=1 SV=1" "0.000" "False" "148.540" "46" "21" "58" "20" "567" "60.2" "4.78" "236.60" "21" "transport" "nucleus;other cell component" "other molecular function" "Pf00638" "8498" "ENSG00000031823" "RANBP3" "B2RAT8; hsa:8498; O60405; O75759; O75760; Q9BT47; Q9H6Z4; Q9UG74" "" "" "0" "0" "1.008" "0.942" "1.003" "1.014" "0.977" "0.995" "1.019" "0.979" "0.797" "4698.2" "4737.9" "4424.8" "4710.3" "4763.8" "4589.9" "4674.2" "4788.7" "4599.2" "3744.7" "" "" "" "" "" "" "" "" "" "" "4224.2" "3833.7" "4002.3" "4597.9" "3931.2" "4589.9" "3499.9" "4229.7" "4115.3" "1336.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1687384969150092260" "False" "High" "IsMasterProtein" "Q96B97" "SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2" "0.000" "False" "148.327" "46" "26" "56" "26" "665" "73.1" "6.62" "221.64" "26" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14604" "30011" "ENSG00000147010" "SH3KBP1" "B7Z1D5; hsa:30011; Q5JPT4; Q5JPT5; Q8IWX6; Q8IX98; Q96B97; Q96RN4; Q9NYR0" "EGF/EGFR signaling pathway" "Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Reelin signalling pathway" "9" "0" "0.974" "0.991" "1.014" "0.995" "0.992" "0.996" "1.003" "0.969" "1.003" "5742.2" "5590.3" "5692.2" "5821.4" "5715.1" "5697.7" "5716.8" "5756.8" "5566.1" "5759.4" "" "" "" "" "" "" "" "" "" "" "5162.8" "4523.4" "5148.7" "5682.5" "4716.2" "5697.7" "4280.6" "5084.7" "4980.5" "2055.9" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135854214922228039" "False" "High" "IsMasterProtein" "Q9BY44" "Eukaryotic translation initiation factor 2A OS=Homo sapiens OX=9606 GN=EIF2A PE=1 SV=3" "0.000" "False" "147.955" "53" "25" "62" "25" "585" "64.9" "8.87" "232.41" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity" "Pf08662" "83939" "ENSG00000144895" "EIF2A" "A8MPS6; B4DF96; B4DQ14; D3DNI9; hsa:83939; Q5QTR2; Q7Z4E9; Q8NFM1; Q96EW9; Q96K81; Q9BY44" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "" "3" "0" "1.020" "1.015" "1.023" "0.995" "0.995" "0.959" "1.022" "1.010" "0.821" "6477.6" "6609.3" "6576.1" "6625.9" "6442.6" "6444.4" "6211.2" "6621.6" "6542.4" "5320.5" "" "" "" "" "" "" "" "" "" "" "5824.0" "5348.0" "5948.3" "6467.8" "5316.6" "6444.4" "4650.8" "5848.6" "5854.1" "1899.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288023909312929848" "False" "High" "IsMasterProtein" "P06744" "Glucose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=GPI PE=1 SV=4" "0.000" "False" "147.443" "40" "23" "97" "15" "558" "63.1" "8.32" "346.41" "23" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "2821" "ENSG00000105220" "GPI" "B4DG39; hsa:2821; P06744; Q9BRD3; Q9BSK5; Q9UHE6" "Cori cycle; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Aerobic glycolysis; N-glycan biosynthesis; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis; Gluconeogenesis; Neutrophil degranulation; TP53 Regulates Metabolic Genes" "13" "7" "1.068" "1.062" "1.072" "1.039" "1.053" "1.046" "1.046" "1.047" "0.780" "8674.3" "9264.4" "9210.8" "9295.9" "9014.4" "9136.9" "9072.8" "9069.3" "9080.6" "6762.0" "" "" "" "" "" "" "" "" "" "" "7799.1" "7496.4" "8331.5" "9074.1" "7438.8" "9136.9" "6793.5" "8010.6" "8125.3" "2413.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3541019235990541605" "False" "High" "IsMasterProtein" "Q9UNM6" "26S proteasome non-ATPase regulatory subunit 13 OS=Homo sapiens OX=9606 GN=PSMD13 PE=1 SV=2" "0.000" "False" "147.426" "68" "25" "74" "25" "376" "42.9" "5.81" "263.90" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "5719" "ENSG00000185627" "PSMD13" "B3KT15; hsa:5719; O75831; Q53XU2; Q9UNM6; Q9UNV3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.018" "1.031" "0.978" "0.989" "0.962" "0.998" "1.008" "1.019" "0.828" "6054.3" "6163.6" "6244.1" "5921.8" "5984.9" "5826.2" "6043.2" "6102.2" "6169.4" "5015.4" "" "" "" "" "" "" "" "" "" "" "5443.4" "4987.4" "5648.0" "5780.5" "4938.8" "5826.2" "4525.0" "5389.9" "5520.4" "1790.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3985188646102169391" "False" "High" "IsMasterProtein" "P53041" "Serine/threonine-protein phosphatase 5 OS=Homo sapiens OX=9606 GN=PPP5C PE=1 SV=1" "0.000" "False" "147.399" "51" "24" "60" "24" "499" "56.8" "6.28" "230.68" "24" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00149, Pf00515, Pf08321" "5536" "ENSG00000011485" "PPP5C" "hsa:5536; P53041; Q16722; Q53XV2" "MAPK signaling pathway; ATM signaling in development and disease" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Negative regulation of MAPK pathway; ESR-mediated signaling" "5" "0" "1.007" "1.066" "1.045" "1.059" "0.995" "1.006" "0.981" "1.036" "0.900" "4714.6" "4747.2" "5024.9" "4925.7" "4992.6" "4692.1" "4742.5" "4623.7" "4886.1" "4241.3" "" "" "" "" "" "" "" "" "" "" "4238.9" "3841.3" "4545.2" "4808.2" "4120.0" "4692.1" "3551.1" "4084.0" "4372.1" "1514.0" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6973365880698085835" "False" "High" "IsMasterProtein" "Q9UHD8" "Septin-9 OS=Homo sapiens OX=9606 GN=SEPTIN9 PE=1 SV=2" "0.000" "False" "147.355" "53" "30" "74" "30" "586" "65.4" "8.97" "253.63" "30" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "10801" "ENSG00000184640" "SEPTIN9" "A8K2V3; B3KPM0; B4DTL9; B4E0N2; B4E274; B7Z654; hsa:10801; Q96QF3; Q96QF4; Q96QF5; Q9HA04; Q9UG40; Q9UHD8; Q9Y5W4" "" "" "0" "0" "0.955" "0.927" "1.049" "0.955" "0.901" "0.983" "0.988" "0.930" "0.866" "6835.0" "6526.9" "6335.4" "7166.8" "6524.5" "6158.8" "6717.1" "6751.5" "6358.3" "5921.8" "" "" "" "" "" "" "" "" "" "" "6145.3" "5281.3" "5730.5" "6995.8" "5384.1" "6158.8" "5029.6" "5963.4" "5689.4" "2113.9" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653265809957974706" "False" "High" "IsMasterProtein" "Q14157" "Ubiquitin-associated protein 2-like OS=Homo sapiens OX=9606 GN=UBAP2L PE=1 SV=2" "0.000" "False" "147.183" "28" "20" "64" "20" "1087" "114.5" "7.11" "285.32" "20" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf12478" "9898" "ENSG00000143569" "UBAP2L" "B4E0U8; hsa:9898; Q14157; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.944" "0.995" "1.001" "0.993" "1.034" "0.977" "1.040" "1.012" "0.806" "6459.7" "6099.4" "6427.6" "6467.3" "6414.1" "6677.4" "6311.2" "6716.4" "6538.5" "5206.9" "" "" "" "" "" "" "" "" "" "" "5807.9" "4935.4" "5814.0" "6313.0" "5293.0" "6677.4" "4725.7" "5932.3" "5850.6" "1858.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3705631994362769923" "False" "High" "IsMasterProtein" "P11413" "Glucose-6-phosphate 1-dehydrogenase OS=Homo sapiens OX=9606 GN=G6PD PE=1 SV=4" "0.000" "False" "146.857" "58" "28" "57" "28" "515" "59.2" "6.84" "216.58" "28" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00479, Pf02781" "2539" "ENSG00000160211" "G6PD" "D3DWX9; hsa:2539; P11413; Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2" "Glutathione metabolism; Pentose phosphate metabolism; Cori cycle; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; ATM signaling in development and disease ; Metabolic reprogramming in colon cancer; Vitamin D-sensitive calcium signaling in depression; Pentose phosphate pathway in senescent cells; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Glycolysis in senescence; Sulfation biotransformation reaction" "TP53 Regulates Metabolic Genes; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway" "16" "0" "1.023" "1.068" "1.008" "1.008" "1.027" "0.990" "1.012" "1.046" "0.806" "5058.6" "5175.9" "5400.8" "5101.4" "5097.5" "5195.1" "5007.4" "5121.1" "5291.5" "4078.2" "" "" "" "" "" "" "" "" "" "" "4548.2" "4188.1" "4885.2" "4979.7" "4206.5" "5195.1" "3749.4" "4523.3" "4734.8" "1455.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5372925708799750934" "False" "High" "IsMasterProtein" "Q15046" "Lysine--tRNA ligase OS=Homo sapiens OX=9606 GN=KARS1 PE=1 SV=3" "0.000" "False" "146.211" "41" "24" "72" "24" "597" "68.0" "6.35" "259.29" "24" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "3735" "ENSG00000065427" "KARS1" "A8MSK1; D3DUK4; hsa:3735; O14946; Q15046; Q96J25; Q9HB23" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.008" "0.984" "1.012" "1.003" "0.940" "1.019" "1.004" "0.983" "1.006" "6749.0" "6804.4" "6641.0" "6831.7" "6767.4" "6343.1" "6875.5" "6775.0" "6631.0" "6786.7" "" "" "" "" "" "" "" "" "" "" "6068.0" "5505.9" "6007.0" "6668.7" "5584.6" "6343.1" "5148.2" "5984.1" "5933.4" "2422.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7476906646827946246" "False" "High" "IsMasterProtein" "Q13315" "Serine-protein kinase ATM OS=Homo sapiens OX=9606 GN=ATM PE=1 SV=4" "0.000" "False" "146.108" "15" "43" "51" "43" "3056" "350.5" "6.81" "167.52" "43" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf11640" "472" "ENSG00000149311" "ATM" "B2RNX5; hsa:472; O15429; Q12758; Q13315; Q16551; Q93007; Q9NP02; Q9UCX7" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Homologous recombination; Glioblastoma signaling pathways; ATM signaling pathway; DDX1 as a regulatory component of the Drosha microprocessor; Ovarian infertility; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; ATM signaling in development and disease ; DNA IR-double strand breaks and cellular response via ATM; miRNA regulation of p53 pathway in prostate cancer; DNA IR-damage and cellular response via ATR; Breast cancer pathway; G1 to S cell cycle control; Joubert syndrome; Male infertility; DNA repair pathways, full network; Pleural mesothelioma; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome; Primary ovarian insufficiency; DNA damage response; DNA damage response (only ATM dependent)" "Autodegradation of the E3 ubiquitin ligase COP1; TP53 Regulates Transcription of DNA Repair Genes; Regulation of HSF1-mediated heat shock response; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Caspase Activators and Caspases; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Sensing of DNA Double Strand Breaks; Pexophagy" "54" "0" "0.943" "0.930" "0.899" "0.939" "0.903" "0.907" "0.942" "0.945" "0.780" "2880.1" "2715.8" "2679.2" "2588.0" "2705.2" "2601.7" "2613.2" "2714.2" "2721.2" "2246.0" "" "" "" "" "" "" "" "" "" "" "2589.5" "2197.6" "2423.4" "2526.2" "2232.4" "2601.7" "1956.7" "2397.3" "2434.9" "801.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4934809763916306973" "False" "High" "IsMasterProtein" "Q6ZS81" "WD repeat- and FYVE domain-containing protein 4 OS=Homo sapiens OX=9606 GN=WDFY4 PE=1 SV=3" "0.000" "False" "145.671" "15" "41" "49" "41" "3184" "353.4" "6.32" "173.37" "41" "other metabolic processes;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf00400, Pf02138" "57705" "ENSG00000128815" "WDFY4" "B9ZVP2; hsa:57705; Q6ZS81; Q86WZ4; Q8N4A3; Q8TEN7; Q96BE1; Q9H7H8; Q9HCG5" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "1.032" "1.002" "0.951" "1.061" "1.025" "1.015" "0.995" "1.032" "1.096" "3172.6" "3275.6" "3179.3" "3017.0" "3366.4" "3252.0" "3221.0" "3157.1" "3274.9" "3478.0" "" "" "" "" "" "" "" "" "" "" "2852.5" "2650.5" "2875.8" "2945.0" "2778.0" "3252.0" "2411.8" "2788.6" "2930.3" "1241.5" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5232006824815591416" "False" "High" "IsMasterProtein" "P14317" "Hematopoietic lineage cell-specific protein OS=Homo sapiens OX=9606 GN=HCLS1 PE=1 SV=3" "0.000" "False" "145.510" "36" "16" "89" "16" "486" "54.0" "4.81" "364.75" "16" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf02218" "3059" "ENSG00000180353" "HCLS1" "B4DQ69; hsa:3059; P14317; Q53Y93; Q6IBK9; Q9UDK0" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; TYROBP causal network in microglia" "" "3" "0" "0.976" "0.988" "1.023" "0.954" "0.956" "0.947" "1.020" "0.968" "0.846" "7212.1" "7036.8" "7128.7" "7380.4" "6879.6" "6893.3" "6833.3" "7356.2" "6983.8" "6105.0" "" "" "" "" "" "" "" "" "" "" "6484.4" "5694.0" "6448.1" "7204.3" "5677.1" "6893.3" "5116.6" "6497.5" "6249.0" "2179.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4137218576109141814" "False" "High" "IsMasterProtein" "Q06210" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Homo sapiens OX=9606 GN=GFPT1 PE=1 SV=3" "0.000" "False" "145.463" "45" "26" "59" "24" "699" "78.8" "7.11" "235.74" "26" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "2673" "ENSG00000198380" "GFPT1" "hsa:2673; Q06210; Q53QE6; Q9BXF8" "UDP-derived sugars synthesis in fibroblasts" "XBP1(S) activates chaperone genes; Synthesis of UDP-N-acetyl-glucosamine; Defective GFPT1 causes CMSTA1" "4" "1" "1.042" "1.027" "0.964" "1.045" "1.002" "0.997" "0.999" "1.022" "0.813" "4623.3" "4816.9" "4748.7" "4456.5" "4830.5" "4633.2" "4609.8" "4620.1" "4726.9" "3760.0" "" "" "" "" "" "" "" "" "" "" "4156.8" "3897.6" "4295.4" "4350.2" "3986.2" "4633.2" "3451.7" "4080.8" "4229.6" "1342.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538896593466497334" "False" "High" "IsMasterProtein" "P23528" "Cofilin-1 OS=Homo sapiens OX=9606 GN=CFL1 PE=1 SV=3" "0.000" "False" "145.388" "86" "25" "143" "19" "166" "18.5" "8.09" "528.20" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1072" "ENSG00000172757" "CFL1" "B3KUQ1; hsa:1072; P23528; Q53Y87; Q9UCA2" "Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Platelet degranulation ; Regulation of actin dynamics for phagocytic cup formation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; RHO GTPases Activate ROCKs" "15" "6" "0.975" "1.010" "1.101" "0.912" "1.076" "0.971" "1.007" "0.975" "0.776" "15861.3" "15458.1" "16027.0" "17465.2" "14459.9" "17062.8" "15404.8" "15973.8" "15467.3" "12306.7" "" "" "" "" "" "" "" "" "" "" "14260.8" "12508.2" "14497.0" "17048.4" "11932.6" "17062.8" "11534.8" "14109.1" "13840.0" "4393.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "657128700828351651" "False" "High" "IsMasterProtein" "Q16643" "Drebrin OS=Homo sapiens OX=9606 GN=DBN1 PE=1 SV=4" "0.000" "False" "145.231" "39" "20" "53" "20" "649" "71.4" "4.45" "220.83" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "1627" "ENSG00000113758" "DBN1" "A8MV58; B2RBG0; hsa:1627; Q16643; Q9UFZ5" "5q35 copy number variation" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; RHOD GTPase cycle; RHOH GTPase cycle" "5" "0" "0.991" "1.056" "1.018" "1.021" "1.040" "1.004" "1.071" "1.073" "0.855" "4008.7" "3972.6" "4234.0" "4080.2" "4091.1" "4167.5" "4026.0" "4295.2" "4301.7" "3428.9" "" "" "" "" "" "" "" "" "" "" "3604.2" "3214.5" "3829.8" "3982.9" "3376.1" "4167.5" "3014.6" "3793.8" "3849.1" "1224.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7312941423538826307" "False" "High" "IsMasterProtein" "P31350" "Ribonucleoside-diphosphate reductase subunit M2 OS=Homo sapiens OX=9606 GN=RRM2 PE=1 SV=1" "0.000" "False" "145.113" "58" "19" "63" "16" "389" "44.8" "5.38" "218.08" "19" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00268" "6241" "ENSG00000171848" "RRM2" "B2R9B5; hsa:6241; J3KP43; P31350; Q5WRU7" "Fluoropyrimidine activity; Retinoblastoma gene in cancer; Hepatitis C and hepatocellular carcinoma; Pyrimidine metabolism; Orexin receptor pathway" "Transcriptional Regulation by E2F6; Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "8" "4" "1.058" "1.556" "0.967" "1.062" "1.540" "1.008" "1.025" "1.565" "0.948" "3997.4" "4231.0" "6221.4" "3867.4" "4244.2" "6155.4" "4030.6" "4098.6" "6255.4" "3790.6" "" "" "" "" "" "" "" "" "" "" "3594.1" "3423.6" "5627.5" "3775.1" "3502.4" "6155.4" "3018.0" "3620.1" "5597.3" "1353.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3936479494832144237" "False" "High" "IsMasterProtein" "Q8TCS8" "Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PNPT1 PE=1 SV=2" "0.000" "False" "144.683" "45" "31" "52" "31" "783" "85.9" "7.77" "192.56" "31" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00575, Pf01138, Pf03725, Pf03726" "87178" "ENSG00000138035" "PNPT1" "hsa:87178; Q53SU0; Q68CN1; Q7Z7D1; Q8IWX1; Q8TCS8; Q96T05; Q9BRU3; Q9BVX0" "Pyrimidine metabolism; miRNA degrading enzymes" "Mitochondrial RNA degradation" "3" "0" "1.012" "0.972" "0.972" "1.026" "0.922" "1.016" "1.010" "0.975" "1.041" "4939.7" "4997.6" "4803.3" "4802.6" "5066.5" "4556.3" "5020.9" "4989.1" "4818.4" "5141.9" "" "" "" "" "" "" "" "" "" "" "4441.3" "4043.8" "4344.7" "4688.0" "4180.9" "4556.3" "3759.5" "4406.7" "4311.5" "1835.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088967002815659299" "False" "High" "IsMasterProtein" "P26641" "Elongation factor 1-gamma OS=Homo sapiens OX=9606 GN=EEF1G PE=1 SV=3" "0.000" "False" "144.644" "57" "25" "77" "25" "437" "50.1" "6.67" "300.54" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf00043, Pf00647, Pf02798" "1937" "ENSG00000254772" "EEF1G" "B4DTG2; hsa:1937; P26641; Q6PJ62; Q6PK31; Q96CU2; Q9P196" "Translation factors" "Signaling by ALK fusions and activated point mutants; Eukaryotic Translation Elongation" "3" "0" "1.007" "0.990" "1.047" "0.970" "1.048" "1.013" "0.995" "0.982" "0.844" "6513.1" "6561.7" "6448.6" "6817.2" "6316.0" "6826.5" "6600.3" "6480.0" "6398.7" "5494.6" "" "" "" "" "" "" "" "" "" "" "5855.9" "5309.5" "5833.0" "6654.5" "5212.1" "6826.5" "4942.2" "5723.6" "5725.5" "1961.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1938619972574952291" "False" "High" "IsMasterProtein" "Q9ULW0" "Targeting protein for Xklp2 OS=Homo sapiens OX=9606 GN=TPX2 PE=1 SV=2" "0.000" "False" "144.602" "47" "30" "58" "30" "747" "85.6" "9.23" "217.18" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06886, Pf09041, Pf12214" "22974" "ENSG00000088325" "TPX2" "hsa:22974; Q96RR5; Q9H1R4; Q9NRA3; Q9UFN9; Q9UL00; Q9ULW0; Q9Y2M1" "Gastric cancer network 1" "Regulation of TP53 Activity through Phosphorylation; AURKA Activation by TPX2" "3" "0" "0.968" "1.322" "0.964" "0.990" "1.385" "0.983" "0.989" "1.289" "0.829" "5036.3" "4875.8" "6657.6" "4856.7" "4984.1" "6976.2" "4948.4" "4978.4" "6492.1" "4176.2" "" "" "" "" "" "" "" "" "" "" "4528.1" "3945.3" "6022.0" "4740.8" "4113.0" "6976.2" "3705.2" "4397.3" "5809.1" "1490.8" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604627173476332081" "False" "High" "IsMasterProtein" "O75534" "Cold shock domain-containing protein E1 OS=Homo sapiens OX=9606 GN=CSDE1 PE=1 SV=2" "0.000" "False" "144.261" "44" "32" "52" "32" "798" "88.8" "6.25" "184.30" "32" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "nucleic acid binding activity" "Pf00313, Pf12901" "7812" "ENSG00000009307" "CSDE1" "A8K281; E9PGZ0; G5E9Q2; hsa:7812; O75534; O94961; Q5TF04; Q5TF05; Q68DF1; Q68DI9; Q9Y2S4" "" "" "0" "0" "1.015" "1.100" "0.990" "0.978" "1.001" "0.999" "0.900" "1.087" "5.677" "3685.2" "3739.7" "4052.4" "3649.4" "3605.9" "3687.5" "3679.8" "3316.6" "4004.1" "20922.4" "" "" "" "" "" "" "" "" "" "" "3313.4" "3026.0" "3665.6" "3562.3" "2975.7" "3687.5" "2755.3" "2929.5" "3582.9" "7468.7" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629412907813045008" "False" "High" "IsMasterProtein" "Q14997" "Proteasome activator complex subunit 4 OS=Homo sapiens OX=9606 GN=PSME4 PE=1 SV=2" "0.000" "False" "144.241" "22" "34" "49" "34" "1843" "211.2" "6.90" "180.18" "34" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11919, Pf16507" "23198" "ENSG00000068878" "PSME4" "hsa:23198; Q14997; Q1XBG4; Q1XBG5; Q1XBG6; Q2M1Z0; Q6IPR2; Q86XF8" "" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway" "52" "0" "0.993" "0.899" "0.947" "0.908" "0.851" "1.007" "0.891" "0.856" "1.147" "3961.4" "3932.9" "3561.3" "3749.6" "3595.5" "3370.3" "3989.2" "3531.3" "3392.2" "4544.7" "" "" "" "" "" "" "" "" "" "" "3561.7" "3182.4" "3221.3" "3660.2" "2967.1" "3370.3" "2987.0" "3119.0" "3035.3" "1622.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2531564844693564972" "False" "High" "IsMasterProtein" "O75475" "PC4 and SFRS1-interacting protein OS=Homo sapiens OX=9606 GN=PSIP1 PE=1 SV=1" "0.000" "False" "144.149" "47" "24" "66" "23" "530" "60.1" "9.13" "244.65" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf11467" "11168" "ENSG00000164985" "PSIP1" "D3DRI9; hsa:11168; O00256; O75475; O95368; Q6P391; Q86YB9; Q9NZI3; Q9UER6" "MECP2 and associated Rett syndrome" "Formation of WDR5-containing histone-modifying complexes; Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection" "8" "1" "0.949" "0.992" "0.942" "0.967" "1.004" "0.925" "0.987" "0.949" "0.840" "8253.8" "7830.2" "8185.5" "7778.9" "7982.2" "8284.1" "7634.9" "8144.2" "7833.2" "6933.7" "" "" "" "" "" "" "" "" "" "" "7421.0" "6336.0" "7404.1" "7593.3" "6587.1" "8284.1" "5716.8" "7193.5" "7009.1" "2475.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009427819375188157" "False" "High" "IsMasterProtein" "P62333" "26S proteasome regulatory subunit 10B OS=Homo sapiens OX=9606 GN=PSMC6 PE=1 SV=1" "0.000" "False" "143.619" "64" "19" "75" "19" "389" "44.1" "7.49" "295.48" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5706" "ENSG00000100519" "PSMC6" "B2R975; hsa:5706; P49719; P62333; Q6IBU3; Q92524" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; SARS-CoV-1 targets host intracellular signalling and regulatory pathways" "65" "0" "1.028" "1.020" "1.027" "1.011" "1.035" "1.029" "1.051" "1.060" "0.994" "5158.5" "5301.0" "5264.0" "5296.0" "5215.6" "5337.2" "5310.1" "5421.4" "5470.2" "5129.2" "" "" "" "" "" "" "" "" "" "" "4638.0" "4289.4" "4761.4" "5169.6" "4304.0" "5337.2" "3976.1" "4788.6" "4894.7" "1831.0" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929162783006905550" "False" "High" "IsMasterProtein" "P20042" "Eukaryotic translation initiation factor 2 subunit 2 OS=Homo sapiens OX=9606 GN=EIF2S2 PE=1 SV=2" "0.000" "False" "143.339" "66" "23" "78" "23" "333" "38.4" "5.80" "283.37" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01873" "8894" "ENSG00000125977" "EIF2S2" "hsa:8894; P20042; Q9BVU0; Q9UJE4" "Translation factors; Brain-derived neurotrophic factor (BDNF) signaling pathway; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell; Primary ovarian insufficiency" "ABC-family proteins mediated transport; PKR-mediated signaling; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "16" "0" "0.995" "0.988" "0.979" "0.959" "0.976" "0.968" "1.003" "0.955" "0.787" "7745.6" "7706.2" "7655.1" "7585.4" "7431.0" "7562.5" "7499.9" "7770.9" "7400.5" "6096.7" "" "" "" "" "" "" "" "" "" "" "6964.1" "6235.6" "6924.3" "7404.4" "6132.2" "7562.5" "5615.7" "6863.8" "6621.9" "2176.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654081652263858131" "False" "High" "IsMasterProtein" "Q12905" "Interleukin enhancer-binding factor 2 OS=Homo sapiens OX=9606 GN=ILF2 PE=1 SV=2" "0.000" "False" "143.307" "56" "17" "59" "17" "390" "43.0" "5.26" "270.34" "17" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07528, Pf20965" "3608" "ENSG00000143621" "ILF2" "A6NDB0; B2R8G7; hsa:3608; Q12905; Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0" "B cell receptor signaling pathway" "Neutrophil degranulation; PKR-mediated signaling" "3" "0" "1.005" "1.011" "0.978" "0.994" "0.989" "0.969" "0.969" "0.960" "0.890" "4590.6" "4613.5" "4640.8" "4489.8" "4565.2" "4541.2" "4448.4" "4448.4" "4408.8" "4083.9" "" "" "" "" "" "" "" "" "" "" "4127.4" "3733.1" "4197.8" "4382.6" "3767.3" "4541.2" "3330.8" "3929.1" "3945.0" "1457.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629883586476679929" "False" "High" "IsMasterProtein" "Q9BT78" "COP9 signalosome complex subunit 4 OS=Homo sapiens OX=9606 GN=COPS4 PE=1 SV=1" "0.000" "False" "142.645" "72" "23" "58" "23" "406" "46.2" "5.83" "234.61" "23" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01399, Pf18420" "51138" "ENSG00000138663" "COPS4" "B3KN88; B3KST5; hsa:51138; Q561W7; Q9BT78; Q9NW31; Q9Y677" "Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; RHOBTB1 GTPase cycle" "6" "0" "1.020" "1.002" "1.011" "1.053" "1.022" "1.055" "1.045" "1.070" "0.842" "4911.2" "5009.6" "4920.3" "4967.2" "5170.4" "5019.8" "5179.3" "5130.3" "5255.5" "4135.3" "" "" "" "" "" "" "" "" "" "" "4415.6" "4053.6" "4450.5" "4848.7" "4266.7" "5019.8" "3878.1" "4531.4" "4702.6" "1476.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5449770128653317074" "False" "High" "IsMasterProtein" "Cont_P15636" "Protease 1 OS=Achromobacter lyticus OX=224 PE=1 SV=1" "0.000" "True" "142.479" "20" "13" "337" "13" "653" "68.1" "7.24" "1558.92" "13" "protein metabolism" "non-structural extracellular" "other molecular function" "Pf01483, Pf18911" "" "" "" "" "" "" "0" "0" "0.981" "0.957" "1.042" "0.896" "0.846" "0.992" "0.913" "0.848" "0.940" "24331.0" "23857.5" "23291.6" "25356.8" "21805.1" "20587.6" "24141.7" "22224.5" "20644.3" "22859.5" "" "" "" "" "" "" "" "" "" "" "21876.0" "19304.6" "21068.1" "24751.8" "17994.0" "20587.6" "18076.7" "19630.1" "18472.4" "8160.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4685450292699183556" "False" "High" "IsMasterProtein" "P43246" "DNA mismatch repair protein Msh2 OS=Homo sapiens OX=9606 GN=MSH2 PE=1 SV=1" "0.000" "False" "142.035" "35" "29" "47" "29" "934" "104.7" "5.77" "181.33" "29" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05190, Pf05192" "4436" "ENSG00000095002" "MSH2" "B4E2Z2; hsa:4436; O75488; P43246" "RAC1/PAK1/p38/MMP2 pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ciliary landscape; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "12" "0" "1.013" "1.027" "0.968" "0.981" "0.966" "0.990" "0.943" "1.009" "1.329" "4335.1" "4391.1" "4451.2" "4196.7" "4253.4" "4188.7" "4291.5" "4087.9" "4374.1" "5760.8" "" "" "" "" "" "" "" "" "" "" "3897.7" "3553.2" "4026.2" "4096.6" "3510.0" "4188.7" "3213.4" "3610.7" "3913.9" "2056.4" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-108024960006830899" "False" "High" "IsMasterProtein" "Q99873" "Protein arginine N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=PRMT1 PE=1 SV=3" "0.000" "False" "141.977" "62" "21" "65" "21" "371" "42.4" "5.35" "243.31" "21" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13649" "3276" "ENSG00000126457" "PRMT1" "A0A087X1W2; B4E3C3; G5E9B6; H7C2I1; hsa:3276; Q15529; Q2VP93; Q6LEU5; Q8WUW5; Q99872; Q99873; Q99874; Q9NZ04; Q9NZ05; Q9NZ06" "Energy metabolism; mRNA processing; Nitric oxide metabolism in cystic fibrosis; 16p11.2 distal deletion syndrome; Interferon type I signaling pathways" "Estrogen-dependent gene expression; Extra-nuclear estrogen signaling; RMTs methylate histone arginines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Maturation of nucleoprotein" "11" "0" "1.003" "1.067" "1.020" "0.974" "1.057" "0.981" "0.971" "1.099" "0.785" "6796.2" "6817.6" "7254.0" "6929.8" "6619.9" "7182.5" "6663.8" "6601.0" "7466.6" "5333.8" "" "" "" "" "" "" "" "" "" "" "6110.4" "5516.6" "6561.5" "6764.4" "5462.9" "7182.5" "4989.7" "5830.4" "6681.1" "1904.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2192359693732382121" "False" "High" "IsMasterProtein" "O95433" "Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Homo sapiens OX=9606 GN=AHSA1 PE=1 SV=1" "0.000" "False" "141.703" "69" "21" "68" "21" "338" "38.3" "5.53" "251.64" "21" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf08327, Pf09229" "10598" "ENSG00000100591" "AHSA1" "B2R9L2; B4DUR9; hsa:10598; O95433; Q96IL6; Q9P060" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "" "1" "0" "1.020" "0.994" "0.990" "1.023" "0.961" "1.002" "1.021" "1.011" "0.923" "6283.6" "6406.8" "6245.5" "6222.0" "6427.3" "6035.8" "6297.0" "6413.0" "6355.1" "5801.9" "" "" "" "" "" "" "" "" "" "" "5649.5" "5184.2" "5649.3" "6073.6" "5304.0" "6035.8" "4715.0" "5664.4" "5686.5" "2071.1" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2098807042560158640" "False" "High" "IsMasterProtein" "P13489" "Ribonuclease inhibitor OS=Homo sapiens OX=9606 GN=RNH1 PE=1 SV=2" "0.000" "False" "141.462" "61" "20" "45" "20" "461" "49.9" "4.82" "195.91" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf13516, Pf18779" "6050" "ENSG00000023191; ENSG00000276230" "RNH1" "hsa:6050; P13489; Q8IZK8; Q96FD7; Q9BQ80; Q9UDK6" "" "" "0" "0" "1.040" "1.029" "0.969" "1.047" "1.004" "1.033" "1.050" "1.016" "0.830" "2703.8" "2812.8" "2782.9" "2620.8" "2830.7" "2713.6" "2792.5" "2840.0" "2747.1" "2245.2" "" "" "" "" "" "" "" "" "" "" "2431.0" "2276.0" "2517.2" "2558.3" "2335.9" "2713.6" "2091.0" "2508.5" "2458.0" "801.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1675638052339020088" "False" "High" "IsMasterProtein" "O75146" "Huntingtin-interacting protein 1-related protein OS=Homo sapiens OX=9606 GN=HIP1R PE=1 SV=2" "0.000" "False" "141.439" "33" "34" "49" "34" "1068" "119.3" "6.67" "179.91" "34" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf01608, Pf07651, Pf16515" "9026" "ENSG00000130787" "HIP1R" "A6NHQ6; hsa:9026; O75146; Q6NXG8; Q9UED9" "5q35 copy number variation" "Clathrin-mediated endocytosis; Golgi Associated Vesicle Biogenesis" "3" "0" "1.025" "1.050" "0.963" "1.000" "1.004" "1.024" "0.967" "0.986" "0.927" "3384.7" "3470.5" "3554.5" "3260.4" "3385.1" "3399.8" "3467.1" "3272.1" "3336.0" "3137.6" "" "" "" "" "" "" "" "" "" "" "3043.1" "2808.2" "3215.1" "3182.6" "2793.4" "3399.8" "2596.1" "2890.2" "2985.0" "1120.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5119731611670534936" "False" "High" "IsMasterProtein" "O60610" "Protein diaphanous homolog 1 OS=Homo sapiens OX=9606 GN=DIAPH1 PE=1 SV=2" "0.000" "False" "141.183" "30" "35" "54" "35" "1272" "141.3" "5.41" "184.90" "35" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06346, Pf06367, Pf06371" "1729" "ENSG00000131504" "DIAPH1" "A6NF18; B7ZKW2; E9PEZ2; hsa:1729; O60610; Q17RN4; Q59FH8; Q9UC76" "Microtubule cytoskeleton regulation; AGE/RAGE pathway; Focal adhesion; Type 2 papillary renal cell carcinoma; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHO GTPases Activate Formins; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; ERBB2 Regulates Cell Motility" "14" "0" "0.975" "0.991" "0.986" "0.970" "1.000" "1.006" "0.916" "0.988" "2.980" "3273.9" "3192.6" "3245.8" "3228.0" "3175.9" "3274.0" "3295.0" "2998.8" "3235.4" "9756.7" "" "" "" "" "" "" "" "" "" "" "2943.5" "2583.4" "2936.0" "3151.0" "2620.8" "3274.0" "2467.2" "2648.8" "2895.0" "3482.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "769140260772308897" "False" "High" "IsMasterProtein" "P07910" "Heterogeneous nuclear ribonucleoproteins C1/C2 OS=Homo sapiens OX=9606 GN=HNRNPC PE=1 SV=4" "0.000" "False" "141.159" "56" "23" "101" "23" "306" "33.7" "5.08" "380.04" "23" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "3183" "ENSG00000092199" "HNRNPC" "D3DS19; D3DS22; hsa:3183; P07910; P22628; Q53EX2; Q59FD3; Q5FWE8; Q86SF8; Q86U45; Q96HK7; Q96HM4; Q96IY5; Q9BTS3" "mRNA processing" "SUMOylation of RNA binding proteins; mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "6" "0" "1.048" "0.897" "0.990" "0.901" "1.041" "0.967" "1.031" "0.822" "1.409" "10436.7" "10942.3" "9359.7" "10335.9" "9399.4" "10860.7" "10094.0" "10757.8" "8578.0" "14710.4" "" "" "" "" "" "" "" "" "" "" "9383.6" "8854.1" "8466.2" "10089.2" "7756.6" "10860.7" "7558.1" "9502.0" "7675.5" "5251.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951583387108982266" "False" "High" "IsMasterProtein" "P11171" "Protein 4.1 OS=Homo sapiens OX=9606 GN=EPB41 PE=1 SV=4" "0.000" "False" "140.937" "39" "31" "60" "31" "864" "97.0" "5.58" "222.98" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf04382, Pf05902, Pf08736, Pf09379, Pf09380" "2035" "ENSG00000159023" "EPB41" "B1ALH8; B1ALH9; D3DPM9; D3DPN0; hsa:2035; P11171; P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579" "VEGFA-VEGFR2 signaling; Splicing factor NOVA regulated synaptic proteins; IL-18 signaling pathway" "Neurexins and neuroligins" "4" "0" "0.983" "0.952" "0.985" "0.990" "0.945" "0.980" "0.974" "0.958" "0.792" "5764.4" "5663.9" "5487.2" "5676.3" "5705.5" "5445.2" "5646.3" "5611.8" "5520.9" "4566.7" "" "" "" "" "" "" "" "" "" "" "5182.8" "4583.0" "4963.3" "5540.8" "4708.3" "5445.2" "4227.8" "4956.7" "4940.1" "1630.2" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3390977729729594241" "False" "High" "IsMasterProtein" "P14735" "Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4" "0.000" "False" "140.793" "28" "29" "49" "29" "1019" "117.9" "6.61" "179.15" "29" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "3416" "ENSG00000119912" "IDE" "B2R721; B7ZAU2; D3DR35; hsa:3416; P14735; Q5T5N2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; Peroxisomal protein import; Insulin receptor recycling" "5" "0" "0.984" "1.069" "1.025" "1.007" "0.992" "1.063" "0.934" "1.019" "1.737" "4226.2" "4157.8" "4516.6" "4331.8" "4256.2" "4191.6" "4493.8" "3949.2" "4306.4" "7341.5" "" "" "" "" "" "" "" "" "" "" "3799.7" "3364.3" "4085.4" "4228.4" "3512.3" "4191.6" "3364.8" "3488.2" "3853.4" "2620.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2176751849839475967" "False" "High" "IsMasterProtein" "P14598" "Neutrophil cytosol factor 1 OS=Homo sapiens OX=9606 GN=NCF1 PE=1 SV=4" "0.000" "False" "140.702" "62" "22" "73" "3" "390" "44.7" "9.13" "274.40" "22" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "653361" "ENSG00000158517" "NCF1" "A6NEH2; A8K7S9; hsa:653361; O43842; P14598; Q2PP07; Q53FR5; Q9BU90; Q9BXI7; Q9BXI8; Q9UDV9; Q9UMU2" "AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; IL-18 signaling pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "16" "21" "1.031" "1.048" "1.052" "1.020" "1.038" "0.996" "1.032" "1.037" "1.159" "5171.9" "5331.3" "5422.0" "5441.7" "5275.8" "5367.0" "5149.1" "5337.9" "5363.8" "5992.5" "" "" "" "" "" "" "" "" "" "" "4650.0" "4313.9" "4904.4" "5311.8" "4353.7" "5367.0" "3855.5" "4714.7" "4799.5" "2139.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2120449807322374936" "False" "High" "IsMasterProtein" "Q9Y2Z0" "Protein SGT1 homolog OS=Homo sapiens OX=9606 GN=SUGT1 PE=1 SV=3" "0.000" "False" "140.302" "53" "19" "58" "19" "365" "41.0" "5.16" "229.46" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04969, Pf05002" "10910" "ENSG00000165416" "SUGT1" "A2A303; hsa:10910; Q5JAK5; Q5TAM6; Q6VXY6; Q9Y2Z0" "Nucleotide-binding oligomerization domain (NOD) pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "0.989" "1.033" "0.995" "0.986" "1.064" "0.955" "1.002" "1.003" "0.912" "7247.1" "7166.1" "7484.5" "7213.7" "7149.1" "7714.2" "6920.1" "7258.7" "7268.5" "6611.1" "" "" "" "" "" "" "" "" "" "" "6515.8" "5798.6" "6769.9" "7041.6" "5899.6" "7714.2" "5181.6" "6411.3" "6503.8" "2360.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8621700409293052339" "False" "High" "IsMasterProtein" "P23368" "NAD-dependent malic enzyme, mitochondrial OS=Homo sapiens OX=9606 GN=ME2 PE=1 SV=1" "0.000" "False" "140.294" "45" "22" "66" "22" "584" "65.4" "7.61" "243.04" "22" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00390, Pf03949" "4200" "ENSG00000082212" "ME2" "B2R8J2; hsa:4200; P23368; Q9BWL6; Q9BYG1; Q9H4B2" "TCA cycle in senescence" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "3" "0" "1.040" "1.006" "1.019" "1.007" "1.020" "0.991" "1.040" "1.038" "0.830" "6136.2" "6383.9" "6173.6" "6252.0" "6179.8" "6257.6" "6079.2" "6380.0" "6369.9" "5095.3" "" "" "" "" "" "" "" "" "" "" "5517.0" "5165.7" "5584.2" "6102.8" "5099.6" "6257.6" "4551.9" "5635.2" "5699.7" "1818.9" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720248987179001386" "False" "High" "IsMasterProtein" "O60313" "Dynamin-like GTPase OPA1, mitochondrial OS=Homo sapiens OX=9606 GN=OPA1 PE=1 SV=3" "0.000" "False" "139.704" "33" "28" "51" "28" "960" "111.6" "7.87" "186.35" "28" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00350, Pf19434" "4976" "ENSG00000198836" "OPA1" "D3DNW4; E5KLJ5; E5KLJ6; E5KLJ7; E5KLK1; E5KLK2; hsa:4976; O60313" "Orexin receptor pathway" "Mitochondrial protein degradation; Regulation of Apoptosis" "3" "0" "1.018" "1.004" "0.964" "0.996" "0.982" "0.941" "0.999" "0.984" "0.756" "4921.6" "5010.5" "4941.7" "4746.1" "4903.2" "4834.7" "4631.4" "4915.9" "4841.9" "3721.4" "" "" "" "" "" "" "" "" "" "" "4425.0" "4054.3" "4469.9" "4632.9" "4046.2" "4834.7" "3467.9" "4342.0" "4332.5" "1328.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1231047339708811007" "False" "High" "IsMasterProtein" "O00203" "AP-3 complex subunit beta-1 OS=Homo sapiens OX=9606 GN=AP3B1 PE=1 SV=3" "0.000" "False" "139.471" "35" "37" "51" "36" "1094" "121.2" "6.04" "176.53" "37" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf14796, Pf14797" "8546" "ENSG00000132842" "AP3B1" "E5RJ68; hsa:8546; O00203; O00580; Q7Z393; Q9HD66" "" "Golgi Associated Vesicle Biogenesis; Signaling by BRAF and RAF1 fusions" "2" "1" "1.044" "0.996" "0.978" "0.992" "0.950" "1.007" "0.980" "0.984" "0.986" "4960.6" "5177.8" "4940.3" "4851.6" "4919.5" "4713.0" "4994.3" "4862.4" "4881.1" "4890.7" "" "" "" "" "" "" "" "" "" "" "4460.1" "4189.7" "4468.6" "4735.9" "4059.6" "4713.0" "3739.6" "4294.8" "4367.5" "1745.9" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299836175419688438" "False" "High" "IsMasterProtein" "P42166" "Lamina-associated polypeptide 2, isoform alpha OS=Homo sapiens OX=9606 GN=TMPO PE=1 SV=2" "0.000" "False" "139.441" "44" "24" "44" "24" "694" "75.4" "7.66" "186.54" "24" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03020, Pf08198, Pf11560" "7112" "ENSG00000120802" "TMPO" "P08918; P08919; P42166; Q14860; Q16295" "Envelope proteins and their potential roles in EDMD physiopathology; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "0" "0.985" "0.983" "1.028" "1.059" "1.015" "1.059" "1.015" "0.960" "1.362" "2781.1" "2739.6" "2733.6" "2859.6" "2946.2" "2822.9" "2945.6" "2821.6" "2671.0" "3788.7" "" "" "" "" "" "" "" "" "" "" "2500.5" "2216.8" "2472.7" "2791.4" "2431.3" "2822.9" "2205.6" "2492.2" "2390.0" "1352.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1302469806401564563" "False" "High" "IsMasterProtein" "P49748" "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADVL PE=1 SV=1" "0.000" "False" "139.256" "52" "27" "57" "27" "655" "70.3" "8.75" "208.65" "27" "other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "37" "ENSG00000072778" "ACADVL" "B4DEB6; F5H2A9; hsa:37; O76056; P49748; Q8WUL0" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation" "XBP1(S) activates chaperone genes; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "4" "0" "1.022" "1.038" "0.965" "1.040" "0.997" "1.028" "1.026" "1.000" "0.872" "4004.4" "4091.7" "4156.7" "3864.0" "4163.7" "3994.1" "4116.5" "4110.1" "4005.5" "3491.9" "" "" "" "" "" "" "" "" "" "" "3600.4" "3310.9" "3759.9" "3771.8" "3436.0" "3994.1" "3082.3" "3630.3" "3584.1" "1246.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5339836283997496681" "False" "High" "IsMasterProtein" "O95163" "Elongator complex protein 1 OS=Homo sapiens OX=9606 GN=ELP1 PE=1 SV=3" "0.000" "False" "139.166" "30" "33" "48" "33" "1332" "150.2" "5.94" "168.58" "33" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04762" "8518" "ENSG00000070061" "ELP1" "hsa:8518; O95163; Q5JSV2; Q9H327; Q9UG87" "HDAC6 interactions in the central nervous system" "HATs acetylate histones" "2" "0" "1.018" "1.005" "0.945" "1.038" "0.955" "1.050" "0.990" "1.012" "0.857" "3453.6" "3515.0" "3470.1" "3263.8" "3583.6" "3296.6" "3626.0" "3420.5" "3494.1" "2959.9" "" "" "" "" "" "" "" "" "" "" "3105.1" "2844.2" "3138.8" "3186.0" "2957.2" "3296.6" "2715.1" "3021.2" "3126.5" "1056.6" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-367492356169293166" "False" "High" "IsMasterProtein" "Q12965" "Unconventional myosin-Ie OS=Homo sapiens OX=9606 GN=MYO1E PE=1 SV=2" "0.000" "False" "138.916" "31" "31" "47" "31" "1108" "127.0" "8.92" "168.40" "31" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00063, Pf06017" "4643" "ENSG00000157483" "MYO1E" "hsa:4643; Q12965; Q14778" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.015" "1.042" "0.990" "1.017" "1.004" "1.017" "0.991" "1.024" "1.198" "4250.0" "4312.8" "4427.9" "4209.6" "4322.6" "4266.2" "4322.8" "4212.5" "4352.0" "5093.5" "" "" "" "" "" "" "" "" "" "" "3821.1" "3489.8" "4005.2" "4109.1" "3567.1" "4266.2" "3236.8" "3720.8" "3894.1" "1818.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6939588679820243468" "False" "High" "IsMasterProtein" "P23193" "Transcription elongation factor A protein 1 OS=Homo sapiens OX=9606 GN=TCEA1 PE=1 SV=2" "0.000" "False" "138.756" "58" "18" "76" "15" "301" "33.9" "8.38" "288.83" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6917" "ENSG00000187735" "TCEA1" "A6NF25; A8K339; hsa:6917; P23193; Q15563; Q6FG87" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "15" "2" "0.894" "0.925" "0.916" "0.953" "0.939" "0.934" "0.989" "0.925" "0.827" "7937.9" "7099.0" "7344.7" "7272.2" "7565.3" "7454.7" "7417.0" "7847.2" "7342.0" "6567.1" "" "" "" "" "" "" "" "" "" "" "7137.0" "5744.2" "6643.5" "7098.6" "6243.0" "7454.7" "5553.7" "6931.1" "6569.6" "2344.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "479793662138796228" "False" "High" "IsMasterProtein" "P61221" "ATP-binding cassette sub-family E member 1 OS=Homo sapiens OX=9606 GN=ABCE1 PE=1 SV=1" "0.000" "False" "138.342" "41" "22" "67" "22" "599" "67.3" "8.34" "274.06" "22" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;translational apparatus;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf00005, Pf00037, Pf04068" "6059" "ENSG00000164163" "ABCE1" "hsa:6059; O88793; P61221; Q13181; Q13864; Q6NR76; Q96AL0; Q96B10; Q99K66" "" "OAS antiviral response; Interferon alpha/beta signaling" "2" "0" "1.017" "1.017" "0.978" "0.991" "0.977" "0.973" "0.967" "0.975" "0.748" "7264.7" "7390.2" "7385.1" "7103.0" "7199.6" "7094.1" "7066.7" "7025.9" "7086.0" "5432.4" "" "" "" "" "" "" "" "" "" "" "6531.7" "5979.9" "6680.1" "6933.5" "5941.2" "7094.1" "5291.4" "6205.7" "6340.5" "1939.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6590851508053806454" "False" "High" "IsMasterProtein" "Q9BQ52" "Zinc phosphodiesterase ELAC protein 2 OS=Homo sapiens OX=9606 GN=ELAC2 PE=1 SV=2" "0.000" "False" "138.297" "42" "27" "47" "27" "826" "92.2" "7.90" "187.72" "27" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12706, Pf13691" "60528" "ENSG00000006744" "ELAC2" "B4DPL9; hsa:60528; Q6IA94; Q9BQ52; Q9HAS8; Q9HAS9; Q9NVT1" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion; rRNA processing in the mitochondrion; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "4" "0" "1.047" "1.038" "0.989" "1.057" "1.046" "1.075" "1.003" "1.033" "1.154" "4037.1" "4225.0" "4188.9" "3991.3" "4266.7" "4224.0" "4340.1" "4050.2" "4169.4" "4659.6" "" "" "" "" "" "" "" "" "" "" "3629.7" "3418.7" "3789.0" "3896.0" "3521.0" "4224.0" "3249.7" "3577.4" "3730.7" "1663.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716088986514922399" "False" "High" "IsMasterProtein" "Q13617" "Cullin-2 OS=Homo sapiens OX=9606 GN=CUL2 PE=1 SV=2" "0.000" "False" "138.258" "42" "28" "52" "28" "745" "86.9" "6.92" "187.23" "28" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "other molecular function" "Pf00888, Pf10557" "8453" "ENSG00000108094" "CUL2" "B3KT95; B7Z6K8; D3DRY6; G3V1S2; hsa:8453; O00200; Q13617; Q5T2B6; Q9UNF9" "Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Regulation of expression of SLITs and ROBOs" "6" "0" "0.986" "1.016" "0.972" "1.041" "0.957" "0.987" "0.987" "0.997" "0.774" "3875.7" "3822.1" "3936.5" "3768.8" "4033.1" "3710.4" "3823.7" "3826.2" "3862.8" "3001.0" "" "" "" "" "" "" "" "" "" "" "3484.6" "3092.7" "3560.7" "3678.9" "3328.2" "3710.4" "2863.1" "3379.6" "3456.4" "1071.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8235165147539186554" "False" "High" "IsMasterProtein" "Q16666" "Gamma-interferon-inducible protein 16 OS=Homo sapiens OX=9606 GN=IFI16 PE=1 SV=3" "0.000" "False" "138.148" "38" "27" "51" "26" "785" "88.2" "9.28" "177.33" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02758, Pf02760" "3428" "ENSG00000163565" "IFI16" "A0A346JEQ3; B4DJT8; H3BLV7; hsa:3428; Q16666; Q59GX0; Q5T3W7; Q5T3W8; Q5T3X0; Q5T3X1; Q5T3X2; Q8N9E5; Q8NEQ7; Q96AJ5; Q9UH78" "" "IRF3-mediated induction of type I IFN" "2" "0" "0.956" "0.883" "0.911" "0.906" "0.903" "0.940" "0.864" "0.839" "1.691" "4487.4" "4289.6" "3963.5" "4086.8" "4066.9" "4052.1" "4217.8" "3876.0" "3763.5" "7588.2" "" "" "" "" "" "" "" "" "" "" "4034.6" "3471.0" "3585.1" "3989.3" "3356.1" "4052.1" "3158.2" "3423.5" "3367.6" "2708.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5241599952766811941" "False" "High" "IsMasterProtein" "P09211" "Glutathione S-transferase P OS=Homo sapiens OX=9606 GN=GSTP1 PE=1 SV=2" "0.000" "False" "138.093" "61" "12" "184" "12" "210" "23.3" "5.64" "795.71" "12" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02798, Pf14497" "2950" "ENSG00000084207" "GSTP1" "hsa:2950; O00460; P09211; Q15690; Q5TZY3" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Exercise-induced circadian regulation; Omega-6-fatty acids in senescence; Arachidonate epoxygenase / epoxide hydrolase; Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Paracetamol ADME; Detoxification of Reactive Oxygen Species; Glutathione conjugation" "11" "0" "1.007" "1.013" "1.117" "0.997" "1.050" "0.997" "1.023" "1.049" "0.772" "14194.8" "14297.9" "14382.2" "15860.5" "14148.7" "14910.4" "14150.4" "14527.0" "14885.6" "10953.8" "" "" "" "" "" "" "" "" "" "" "12762.5" "11569.4" "13009.2" "15482.1" "11675.8" "14910.4" "10595.5" "12831.2" "13319.6" "3910.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7622231560690593168" "False" "High" "IsMasterProtein" "Q13043" "Serine/threonine-protein kinase 4 OS=Homo sapiens OX=9606 GN=STK4 PE=1 SV=2" "0.000" "False" "138.062" "46" "20" "62" "13" "487" "55.6" "5.07" "214.77" "20" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6789" "ENSG00000101109" "STK4" "B2RCR8; hsa:6789; Q13043; Q15802; Q4G156; Q5H982; Q6PD60; Q9BR32; Q9NTZ4" "MAPK signaling pathway; Ras signaling; Non-small cell lung cancer" "Signaling by Hippo" "4" "8" "0.979" "0.986" "0.979" "0.984" "0.965" "0.978" "1.001" "1.000" "0.898" "5352.4" "5239.8" "5275.5" "5241.6" "5267.3" "5166.9" "5237.1" "5360.3" "5353.5" "4808.2" "" "" "" "" "" "" "" "" "" "" "4812.3" "4239.9" "4771.9" "5116.5" "4346.7" "5166.9" "3921.4" "4734.6" "4790.3" "1716.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8484028389043526679" "False" "High" "IsMasterProtein" "P13010" "X-ray repair cross-complementing protein 5 OS=Homo sapiens OX=9606 GN=XRCC5 PE=1 SV=3" "0.000" "False" "137.888" "44" "27" "49" "27" "732" "82.7" "5.81" "198.52" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02735, Pf03730, Pf03731, Pf08785" "7520" "ENSG00000079246" "XRCC5" "A8K3X5; hsa:7520; P13010; Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network" "Neutrophil degranulation; Cytosolic sensors of pathogen-associated DNA ; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation; IRF3-mediated induction of type I IFN" "9" "0" "0.884" "0.755" "0.999" "0.873" "0.767" "1.028" "0.697" "0.742" "7.726" "3739.2" "3304.0" "2824.3" "3735.1" "3264.6" "2869.8" "3844.2" "2607.0" "2773.6" "28887.9" "" "" "" "" "" "" "" "" "" "" "3361.9" "2673.4" "2554.7" "3646.0" "2694.0" "2869.8" "2878.4" "2302.7" "2481.8" "10312.2" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190744193783032342" "False" "High" "IsMasterProtein" "Q92619" "Rho GTPase-activating protein 45 OS=Homo sapiens OX=9606 GN=ARHGAP45 PE=1 SV=2" "0.000" "False" "137.765" "33" "31" "55" "31" "1136" "124.5" "6.10" "209.71" "31" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620" "23526" "ENSG00000180448" "ARHGAP45" "B4DTS4; F6QP70; hsa:23526; Q6P189; Q7LE26; Q86WS1; Q8HX84; Q92619; Q9GJN9; Q9GJP0; Q9GJP1; Q9MY24" "" "Neutrophil degranulation; RAC1 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle" "4" "0" "0.986" "0.969" "1.007" "1.001" "0.941" "1.007" "1.010" "0.988" "0.879" "5308.4" "5235.5" "5142.1" "5344.6" "5312.1" "4996.1" "5345.5" "5360.9" "5245.9" "4664.6" "" "" "" "" "" "" "" "" "" "" "4772.8" "4236.4" "4651.2" "5217.1" "4383.6" "4996.1" "4002.6" "4735.1" "4694.0" "1665.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5165886701298417594" "False" "High" "IsMasterProtein" "Q15459" "Splicing factor 3A subunit 1 OS=Homo sapiens OX=9606 GN=SF3A1 PE=1 SV=1" "0.000" "False" "137.419" "30" "22" "65" "22" "793" "88.8" "5.22" "237.08" "22" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00240, Pf01805, Pf12230" "10291" "ENSG00000099995" "SF3A1" "E9PAW1; hsa:10291; Q15459" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.987" "0.977" "0.986" "0.977" "0.939" "0.975" "0.961" "0.947" "1.399" "7373.5" "7277.2" "7202.9" "7268.0" "7200.7" "6925.7" "7186.3" "7088.1" "6980.6" "10317.6" "" "" "" "" "" "" "" "" "" "" "6629.5" "5888.4" "6515.3" "7094.6" "5942.1" "6925.7" "5380.9" "6260.7" "6246.2" "3683.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4445993330794884217" "False" "High" "IsMasterProtein" "P54577" "Tyrosine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=YARS1 PE=1 SV=4" "0.000" "False" "137.371" "55" "28" "54" "28" "528" "59.1" "7.05" "197.86" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00579, Pf01588" "8565" "ENSG00000134684" "YARS1" "B3KWK4; D3DPQ4; hsa:8565; O43276; P54577; Q53EN1" "Nephrotic syndrome" "Cytosolic tRNA aminoacylation" "2" "0" "0.965" "0.937" "0.995" "0.959" "0.906" "1.024" "0.945" "0.952" "2.356" "5591.1" "5397.4" "5240.2" "5565.9" "5359.8" "5065.5" "5725.8" "5285.6" "5324.9" "13173.7" "" "" "" "" "" "" "" "" "" "" "5026.9" "4367.4" "4739.9" "5433.1" "4423.0" "5065.5" "4287.3" "4668.6" "4764.7" "4702.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2921825731244054349" "False" "High" "IsMasterProtein" "Q99714" "3-hydroxyacyl-CoA dehydrogenase type-2 OS=Homo sapiens OX=9606 GN=HSD17B10 PE=1 SV=3" "0.000" "False" "137.300" "72" "14" "69" "14" "261" "26.9" "7.78" "320.81" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00106" "3028" "ENSG00000072506" "HSD17B10" "hsa:3028; Q5H927; Q6IBS9; Q8TCV9; Q96HD5; Q99714" "Alzheimer's disease and miRNA effects; Valproic acid pathway; Alzheimer's disease" "Branched-chain amino acid catabolism; Mitochondrial protein degradation; tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "8" "0" "1.036" "0.999" "0.990" "1.020" "0.990" "0.979" "1.017" "1.013" "0.788" "5765.1" "5970.1" "5760.9" "5707.4" "5879.6" "5709.2" "5646.4" "5861.6" "5840.1" "4540.4" "" "" "" "" "" "" "" "" "" "" "5183.4" "4830.8" "5210.9" "5571.3" "4851.9" "5709.2" "4227.9" "5177.4" "5225.7" "1620.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8833094404749326966" "False" "High" "IsMasterProtein" "Q9Y285" "Phenylalanine--tRNA ligase alpha subunit OS=Homo sapiens OX=9606 GN=FARSA PE=1 SV=3" "0.000" "False" "137.062" "43" "19" "66" "19" "508" "57.5" "7.80" "238.60" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf18552, Pf18553, Pf18554" "2193" "ENSG00000179115" "FARSA" "B4E363; hsa:2193; Q9NSD8; Q9Y285; Q9Y4W8" "" "Cytosolic tRNA aminoacylation" "1" "0" "1.024" "0.973" "1.020" "0.996" "0.956" "0.979" "0.997" "0.979" "0.907" "4326.8" "4430.5" "4210.1" "4411.9" "4308.2" "4137.3" "4236.9" "4312.0" "4234.5" "3925.4" "" "" "" "" "" "" "" "" "" "" "3890.2" "3585.0" "3808.2" "4306.6" "3555.2" "4137.3" "3172.5" "3808.7" "3789.0" "1401.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1908270249902800016" "False" "High" "IsMasterProtein" "P35573" "Glycogen debranching enzyme OS=Homo sapiens OX=9606 GN=AGL PE=1 SV=3" "0.000" "False" "137.049" "29" "37" "47" "37" "1532" "174.7" "6.76" "164.52" "37" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06202, Pf14699, Pf14701, Pf14702" "178" "ENSG00000162688" "AGL" "A6NCX7; A6NEK2; D3DT51; hsa:178; P35573; P78354; P78544; Q59H92; Q6AZ90; Q9UF08" "Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "3" "0" "1.002" "0.898" "1.014" "0.977" "0.877" "1.022" "0.983" "0.918" "0.807" "3896.3" "3904.2" "3499.3" "3952.4" "3806.9" "3418.9" "3980.1" "3829.8" "3575.5" "3142.6" "" "" "" "" "" "" "" "" "" "" "3503.1" "3159.1" "3165.2" "3858.1" "3141.5" "3418.9" "2980.2" "3382.7" "3199.4" "1121.8" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3689423794866279404" "False" "High" "IsMasterProtein" "Q8N8A2" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens OX=9606 GN=ANKRD44 PE=1 SV=3" "0.000" "False" "137.045" "35" "26" "39" "24" "993" "107.5" "6.30" "167.23" "26" "" "" "" "Pf12796" "91526" "ENSG00000065413" "ANKRD44" "hsa:91526; Q53SL9; Q6P480; Q86VL5; Q8IZ72; Q8N8A2; Q9UFA4" "" "" "0" "2" "1.005" "0.947" "0.939" "0.990" "0.920" "0.932" "1.009" "0.990" "0.918" "3368.0" "3384.5" "3190.2" "3163.9" "3334.3" "3098.8" "3138.1" "3396.7" "3335.2" "3090.8" "" "" "" "" "" "" "" "" "" "" "3028.2" "2738.6" "2885.7" "3088.4" "2751.6" "3098.8" "2349.8" "3000.2" "2984.3" "1103.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3241468308071992901" "False" "High" "IsMasterProtein" "Q8NI08" "Nuclear receptor coactivator 7 OS=Homo sapiens OX=9606 GN=NCOA7 PE=1 SV=2" "0.000" "False" "136.922" "37" "26" "42" "26" "942" "106.1" "5.59" "178.10" "26" "stress response;other biological processes" "nucleus" "other molecular function" "Pf01476, Pf07534" "135112" "ENSG00000111912" "NCOA7" "B2RNS2; B7Z2C4; B9EH71; G8JL91; hsa:135112; Q3LID6; Q4G0V1; Q5TF95; Q6IPQ4; Q6NE83; Q86T89; Q8N1W4; Q8NI08" "Aryl hydrocarbon receptor pathway" "" "1" "0" "0.977" "0.957" "0.982" "1.019" "0.929" "0.983" "0.983" "0.945" "0.957" "3811.5" "3725.4" "3647.2" "3744.5" "3884.3" "3542.3" "3744.9" "3745.3" "3602.4" "3647.3" "" "" "" "" "" "" "" "" "" "" "3426.9" "3014.5" "3299.0" "3655.2" "3205.4" "3542.3" "2804.1" "3308.1" "3223.4" "1302.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7577661902964436810" "False" "High" "IsMasterProtein" "Q3LXA3" "Triokinase/FMN cyclase OS=Homo sapiens OX=9606 GN=TKFC PE=1 SV=2" "0.000" "False" "136.617" "53" "22" "48" "22" "575" "58.9" "7.49" "219.75" "22" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf02733, Pf02734" "26007" "ENSG00000149476" "TKFC" "hsa:26007; Q2L9C1; Q3LXA3; Q53EQ9; Q9BVA7; Q9H895" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; Fructose catabolism" "5" "0" "0.999" "0.951" "0.957" "1.036" "0.940" "1.005" "1.005" "0.969" "0.798" "3913.2" "3907.6" "3720.7" "3746.1" "4056.0" "3678.5" "3932.4" "3933.2" "3793.1" "3123.9" "" "" "" "" "" "" "" "" "" "" "3518.3" "3161.9" "3365.5" "3656.7" "3347.1" "3678.5" "2944.5" "3474.0" "3394.0" "1115.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1047543099056468626" "False" "High" "IsMasterProtein" "P09104" "Gamma-enolase OS=Homo sapiens OX=9606 GN=ENO2 PE=1 SV=3" "0.000" "False" "136.535" "59" "18" "73" "14" "434" "47.2" "5.03" "330.52" "18" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00113, Pf03952" "2026" "ENSG00000111674" "ENO2" "B7Z2X9; hsa:2026; P09104; Q96J33" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "1" "1.006" "1.054" "1.049" "1.093" "1.059" "0.988" "0.990" "1.082" "0.887" "2736.6" "2753.7" "2885.3" "2870.0" "2991.5" "2899.2" "2703.6" "2708.5" "2962.0" "2428.5" "" "" "" "" "" "" "" "" "" "" "2460.4" "2228.2" "2609.8" "2801.5" "2468.6" "2899.2" "2024.4" "2392.3" "2650.3" "866.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585678134614880292" "False" "High" "IsMasterProtein" "Q9NTK5" "Obg-like ATPase 1 OS=Homo sapiens OX=9606 GN=OLA1 PE=1 SV=2" "0.000" "False" "136.485" "61" "24" "72" "24" "396" "44.7" "7.81" "253.23" "24" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "translation activity;other molecular function" "Pf01926, Pf06071" "29789" "ENSG00000138430" "OLA1" "D7EHM2; hsa:29789; Q5BJD7; Q8NCI8; Q96CU1; Q96SV2; Q9NTK5; Q9P1D3; Q9UNY9; Q9Y6G4" "" "Platelet degranulation" "1" "0" "1.028" "1.013" "1.065" "0.983" "1.028" "0.962" "1.028" "1.014" "0.772" "8510.9" "8749.6" "8622.7" "9060.7" "8363.9" "8751.1" "8184.6" "8745.2" "8631.9" "6566.6" "" "" "" "" "" "" "" "" "" "" "7652.2" "7079.9" "7799.5" "8844.5" "6902.0" "8751.1" "6128.4" "7724.3" "7723.8" "2344.1" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3011469150095823870" "False" "High" "IsMasterProtein" "Q9Y696" "Chloride intracellular channel protein 4 OS=Homo sapiens OX=9606 GN=CLIC4 PE=1 SV=4" "0.000" "False" "136.426" "72" "17" "63" "17" "253" "28.8" "5.59" "274.47" "17" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "transporter activity" "Pf13409" "25932" "ENSG00000169504" "CLIC4" "hsa:25932; Q9UFW9; Q9UQJ6; Q9Y696" "" "" "0" "0" "0.953" "0.956" "0.970" "1.021" "0.920" "0.976" "1.003" "0.999" "0.783" "5814.8" "5542.9" "5561.6" "5643.2" "5934.6" "5350.5" "5673.1" "5832.2" "5808.1" "4553.7" "" "" "" "" "" "" "" "" "" "" "5228.1" "4485.1" "5030.7" "5508.6" "4897.3" "5350.5" "4247.9" "5151.3" "5197.0" "1625.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4377208032786879179" "False" "High" "IsMasterProtein" "P51858" "Hepatoma-derived growth factor OS=Homo sapiens OX=9606 GN=HDGF PE=1 SV=1" "0.000" "False" "136.112" "68" "16" "84" "15" "240" "26.8" "4.73" "336.92" "16" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00855" "3068" "ENSG00000143321" "HDGF" "B3KU21; D3DVC9; P51858; Q5SZ07; Q5SZ08; Q5SZ09" "IL-18 signaling pathway" "XBP1(S) activates chaperone genes" "2" "0" "0.956" "0.896" "0.952" "0.957" "0.914" "0.948" "1.009" "0.878" "0.780" "11231.9" "10742.0" "10067.7" "10692.7" "10751.4" "10264.3" "10648.3" "11335.2" "9860.5" "8762.2" "" "" "" "" "" "" "" "" "" "" "10098.6" "8692.1" "9106.5" "10437.6" "8872.3" "10264.3" "7973.1" "10012.0" "8823.1" "3127.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5974744531153524067" "False" "High" "IsMasterProtein" "Q01581" "Hydroxymethylglutaryl-CoA synthase, cytoplasmic OS=Homo sapiens OX=9606 GN=HMGCS1 PE=1 SV=2" "0.000" "False" "136.110" "38" "19" "63" "19" "520" "57.3" "5.41" "248.12" "19" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01154, Pf08540" "3157" "ENSG00000112972" "HMGCS1" "B2RDL8; hsa:3157; Q01581" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "13" "0" "0.974" "1.161" "1.049" "0.946" "1.122" "0.942" "0.972" "1.184" "0.835" "9402.3" "9155.9" "10914.7" "9861.4" "8896.8" "10549.5" "8860.0" "9140.2" "11134.6" "7850.7" "" "" "" "" "" "" "" "" "" "" "8453.6" "7408.6" "9872.7" "9626.1" "7341.8" "10549.5" "6634.1" "8073.2" "9963.1" "2802.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064458318068970757" "False" "High" "IsMasterProtein" "Q96QK1" "Vacuolar protein sorting-associated protein 35 OS=Homo sapiens OX=9606 GN=VPS35 PE=1 SV=2" "0.000" "False" "135.981" "34" "27" "53" "27" "796" "91.6" "5.49" "196.70" "27" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf03635" "55737" "ENSG00000069329" "VPS35" "hsa:55737; Q561W2; Q96QK1; Q9H016; Q9H096; Q9H4P3; Q9H8J0; Q9NRS7; Q9NVG2; Q9NX80; Q9NZK2" "" "WNT ligand biogenesis and trafficking" "1" "0" "1.028" "1.000" "0.952" "1.019" "0.953" "0.998" "1.002" "1.003" "0.850" "4451.9" "4578.1" "4451.6" "4237.6" "4535.0" "4241.6" "4444.3" "4459.7" "4467.0" "3784.3" "" "" "" "" "" "" "" "" "" "" "4002.7" "3704.4" "4026.6" "4136.5" "3742.4" "4241.6" "3327.8" "3939.1" "3997.1" "1350.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500586164942944818" "False" "High" "IsMasterProtein" "P67809" "Y-box-binding protein 1 OS=Homo sapiens OX=9606 GN=YBX1 PE=1 SV=3" "0.000" "False" "135.958" "56" "17" "115" "17" "324" "35.9" "9.88" "404.08" "17" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "4904" "ENSG00000065978" "YBX1" "hsa:4904; P16990; P16991; P67809; Q14972; Q15325; Q5FVF0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; MECP2 and associated Rett syndrome; mRNA processing; Sudden infant death syndrome (SIDS) susceptibility pathways" "mRNA Splicing - Major Pathway; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Noncanonical activation of NOTCH3" "10" "0" "1.049" "0.987" "1.045" "0.988" "1.142" "1.019" "1.082" "1.022" "0.826" "3995.2" "4191.8" "3944.7" "4176.6" "3947.7" "4563.4" "4071.2" "4321.9" "4084.9" "3298.8" "" "" "" "" "" "" "" "" "" "" "3592.1" "3391.9" "3568.1" "4077.0" "3257.7" "4563.4" "3048.4" "3817.4" "3655.1" "1177.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4945442823809026460" "False" "High" "IsMasterProtein" "O95861" "3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens OX=9606 GN=BPNT1 PE=1 SV=1" "0.000" "False" "135.949" "69" "18" "63" "18" "308" "33.4" "5.69" "242.63" "18" "other metabolic processes;developmental processes" "cytosol" "other molecular function" "Pf00459" "10380" "ENSG00000162813" "BPNT1" "A8K7C8; B4DPS5; B4DUS9; D3DTA9; hsa:10380; O95861; Q8WVL5; Q9UGJ3" "" "Cytosolic sulfonation of small molecules" "1" "0" "1.036" "0.997" "1.035" "1.023" "0.971" "1.020" "1.053" "1.012" "0.806" "5284.5" "5473.2" "5267.4" "5468.8" "5407.1" "5131.4" "5390.4" "5563.1" "5346.0" "4258.5" "" "" "" "" "" "" "" "" "" "" "4751.3" "4428.7" "4764.5" "5338.3" "4462.0" "5131.4" "4036.2" "4913.7" "4783.6" "1520.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1811724669038293962" "False" "High" "IsMasterProtein" "Q96RP9" "Elongation factor G, mitochondrial OS=Homo sapiens OX=9606 GN=GFM1 PE=1 SV=2" "0.000" "False" "135.878" "40" "28" "53" "28" "751" "83.4" "7.01" "183.98" "28" "protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "85476" "ENSG00000168827" "GFM1" "A6NCI9; B2RCB9; B3KRW1; hsa:85476; Q6GTN2; Q96RP9; Q96T39" "" "Mitochondrial translation elongation" "1" "0" "0.988" "0.968" "0.967" "0.989" "0.911" "0.977" "0.953" "0.943" "0.976" "6425.7" "6346.5" "6223.0" "6214.8" "6353.3" "5856.4" "6276.9" "6124.9" "6059.4" "6269.1" "" "" "" "" "" "" "" "" "" "" "5777.3" "5135.4" "5628.9" "6066.6" "5242.9" "5856.4" "4700.0" "5409.9" "5421.9" "2237.9" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2527179580342077355" "False" "High" "IsMasterProtein" "Q9NUQ9" "CYFIP-related Rac1 interactor B OS=Homo sapiens OX=9606 GN=CYRIB PE=1 SV=1" "0.000" "False" "135.805" "64" "18" "70" "16" "324" "36.7" "6.06" "280.16" "18" "cell organization and biogenesis;other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07159" "51571" "ENSG00000153310" "CYRIB" "hsa:51571; Q96AZ5; Q9NUQ9; Q9NW21; Q9NZE7" "" "Platelet degranulation" "1" "3" "1.030" "0.996" "1.046" "1.044" "0.977" "1.006" "1.007" "1.039" "0.819" "4955.7" "5104.4" "4935.3" "5182.7" "5171.7" "4840.8" "4987.2" "4992.5" "5149.0" "4057.1" "" "" "" "" "" "" "" "" "" "" "4455.7" "4130.3" "4464.1" "5059.0" "4267.8" "4840.8" "3734.3" "4409.7" "4607.3" "1448.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4014732936272449079" "False" "High" "IsMasterProtein" "Q53EL6" "Programmed cell death protein 4 OS=Homo sapiens OX=9606 GN=PDCD4 PE=1 SV=2" "0.000" "False" "135.633" "59" "20" "47" "20" "469" "51.7" "5.21" "200.78" "20" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02847" "27250" "ENSG00000150593" "PDCD4" "B2RCV4; B5ME91; hsa:27250; O15501; Q53EL6; Q5VZS6; Q6PJI5; Q8TAR5; Q99834" "Translation inhibitors in chronically activated PDGFRA cells; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "0.983" "0.731" "1.013" "1.099" "0.767" "1.065" "1.058" "0.820" "0.702" "4312.6" "4241.2" "3154.6" "4369.6" "4740.9" "3305.8" "4590.9" "4562.7" "3537.0" "3027.5" "" "" "" "" "" "" "" "" "" "" "3877.5" "3431.8" "2853.4" "4265.4" "3912.3" "3305.8" "3437.5" "4030.0" "3164.9" "1080.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4780754661784181438" "False" "High" "IsMasterProtein" "O95373" "Importin-7 OS=Homo sapiens OX=9606 GN=IPO7 PE=1 SV=1" "0.000" "False" "135.487" "27" "23" "47" "22" "1038" "119.4" "4.82" "187.24" "23" "stress response;transport;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf03810, Pf08506" "10527" "ENSG00000205339" "IPO7" "A6NNM5; B2R786; hsa:10527; O95373; Q1RMF7; Q9H177; Q9NTE3" "" "" "0" "1" "0.998" "1.059" "0.982" "0.985" "0.960" "1.024" "0.943" "0.987" "1.311" "4968.7" "4958.4" "5262.6" "4881.2" "4896.5" "4767.8" "5085.9" "4684.8" "4902.0" "6513.4" "" "" "" "" "" "" "" "" "" "" "4467.3" "4012.1" "4760.2" "4764.7" "4040.7" "4767.8" "3808.2" "4137.9" "4386.3" "2325.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386147216843783893" "False" "High" "IsMasterProtein" "Q9NUU7" "ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1" "0.000" "False" "135.392" "53" "23" "52" "23" "478" "53.9" "6.58" "210.90" "23" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55308" "ENSG00000168872" "DDX19A" "B2RPL0; B4DRZ7; hsa:55308; Q53FM0; Q9NUU7" "" "" "0" "0" "1.044" "1.124" "1.003" "1.039" "1.069" "1.037" "1.037" "1.062" "1.064" "5698.4" "5951.4" "6402.5" "5715.6" "5920.6" "6090.9" "5909.7" "5909.5" "6049.9" "6062.8" "" "" "" "" "" "" "" "" "" "" "5123.4" "4815.6" "5791.3" "5579.2" "4885.8" "6090.9" "4425.0" "5219.6" "5413.4" "2164.2" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4701772359172858038" "False" "High" "IsMasterProtein" "P49790" "Nuclear pore complex protein Nup153 OS=Homo sapiens OX=9606 GN=NUP153 PE=1 SV=2" "0.000" "False" "135.326" "29" "35" "49" "35" "1475" "153.8" "8.73" "176.04" "35" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf08604, Pf10599" "9972" "ENSG00000124789" "NUP153" "B4DIK2; E7EPX5; F6QR24; hsa:9972; P49790; Q4LE47; Q5T9I7; Q7Z743" "TGF-beta signaling pathway" "Nuclear import of Rev protein; HCMV Late Events; HCMV Early Events; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "1.012" "0.978" "0.983" "1.011" "0.977" "0.996" "1.000" "0.955" "0.860" "5711.1" "5779.1" "5583.5" "5612.3" "5771.1" "5578.0" "5687.1" "5708.8" "5455.4" "4914.2" "" "" "" "" "" "" "" "" "" "" "5134.9" "4676.2" "5050.4" "5478.4" "4762.4" "5578.0" "4258.4" "5042.4" "4881.5" "1754.2" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9022416781062355686" "False" "High" "IsMasterProtein" "Q9UPU5" "Ubiquitin carboxyl-terminal hydrolase 24 OS=Homo sapiens OX=9606 GN=USP24 PE=1 SV=3" "0.000" "False" "135.175" "15" "36" "43" "36" "2620" "294.2" "6.14" "149.77" "36" "protein metabolism" "cytosol;nucleus" "other molecular function" "Pf00443" "23358" "ENSG00000162402" "USP24" "hsa:23358; Q6ZSY2; Q8N2Y4; Q9NXD1; Q9UPU5" "" "Ub-specific processing proteases" "1" "0" "1.019" "0.931" "0.944" "0.964" "0.882" "1.023" "0.938" "0.912" "1.158" "3239.2" "3300.3" "3014.7" "3059.4" "3121.2" "2856.7" "3314.1" "3038.7" "2953.6" "3750.0" "" "" "" "" "" "" "" "" "" "" "2912.3" "2670.5" "2726.9" "2986.4" "2575.7" "2856.7" "2481.5" "2684.0" "2642.9" "1338.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375122853346024923" "False" "High" "IsMasterProtein" "Q9C0E2" "Exportin-4 OS=Homo sapiens OX=9606 GN=XPO4 PE=1 SV=2" "0.000" "False" "135.110" "29" "28" "46" "27" "1151" "130.1" "5.05" "191.40" "28" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08767" "64328" "ENSG00000132953" "XPO4" "hsa:64328; Q5VUZ5; Q8N3V6; Q9C0E2; Q9H934" "eIF5A regulation in response to inhibition of the nuclear export system" "" "1" "1" "1.094" "1.006" "0.961" "1.112" "0.989" "1.068" "1.047" "1.010" "0.837" "3554.0" "3889.7" "3576.8" "3415.0" "3951.0" "3513.6" "3796.9" "3720.7" "3590.8" "2973.8" "" "" "" "" "" "" "" "" "" "" "3195.4" "3147.4" "3235.4" "3333.5" "3260.4" "3513.6" "2843.0" "3286.4" "3213.0" "1061.5" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3533447776593040930" "False" "High" "IsMasterProtein" "P26599" "Polypyrimidine tract-binding protein 1 OS=Homo sapiens OX=9606 GN=PTBP1 PE=1 SV=2" "0.000" "False" "135.039" "38" "16" "68" "13" "557" "59.6" "9.16" "305.88" "16" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "5725" "ENSG00000011304" "PTBP1" "hsa:5725; P26599; Q9BUQ0" "mir-124 predicted interactions with cell cycle and differentiation ; mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "5" "4" "1.009" "1.085" "1.021" "0.992" "1.038" "1.010" "1.041" "1.005" "0.922" "4079.5" "4116.5" "4426.2" "4163.9" "4046.8" "4233.8" "4119.2" "4247.4" "4099.8" "3760.2" "" "" "" "" "" "" "" "" "" "" "3667.9" "3330.9" "4003.6" "4064.6" "3339.5" "4233.8" "3084.3" "3751.6" "3668.5" "1342.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1710957495581241362" "False" "High" "IsMasterProtein" "Q15276" "Rab GTPase-binding effector protein 1 OS=Homo sapiens OX=9606 GN=RABEP1 PE=1 SV=2" "0.000" "False" "134.907" "40" "35" "45" "35" "862" "99.2" "5.01" "177.77" "35" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03528, Pf09311" "9135" "ENSG00000029725" "RABEP1" "B2RAG7; hsa:9135; O95369; Q15276; Q8IVX3" "GDNF signaling" "TBC/RABGAPs" "2" "0" "1.015" "0.977" "0.981" "1.024" "0.988" "1.018" "1.023" "0.994" "0.936" "5043.0" "5117.5" "4927.0" "4947.3" "5161.8" "4983.5" "5135.0" "5158.1" "5014.1" "4722.3" "" "" "" "" "" "" "" "" "" "" "4534.1" "4140.9" "4456.6" "4829.3" "4259.6" "4983.5" "3844.9" "4555.9" "4486.6" "1685.7" "30" "30" "30" "30" "30" "30" "30" "30" "30" "30" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4058456233631452436" "False" "High" "IsMasterProtein" "Q06830" "Peroxiredoxin-1 OS=Homo sapiens OX=9606 GN=PRDX1 PE=1 SV=1" "0.000" "False" "134.591" "75" "17" "124" "13" "199" "22.1" "8.13" "425.97" "17" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00578, Pf10417" "5052" "ENSG00000117450" "PRDX1" "B5BU26; D3DPZ8; hsa:5052; P35703; Q06830; Q2V576; Q5T154; Q5T155" "Androgen receptor signaling pathway; Selenium micronutrient network; Nuclear receptors meta-pathway; NRF2 pathway; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; NFE2L2 regulating anti-oxidant/detoxification enzymes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "9" "4" "0.971" "0.997" "1.033" "0.934" "0.959" "0.959" "1.000" "0.999" "0.773" "14824.0" "14390.9" "14777.2" "15316.4" "13852.8" "14210.5" "14223.2" "14818.9" "14804.6" "11456.1" "" "" "" "" "" "" "" "" "" "" "13328.2" "11644.6" "13366.5" "14950.9" "11431.6" "14210.5" "10650.0" "13089.0" "13247.0" "4089.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3614500297026839647" "False" "High" "IsMasterProtein" "Q9Y266" "Nuclear migration protein nudC OS=Homo sapiens OX=9606 GN=NUDC PE=1 SV=1" "0.000" "False" "133.780" "52" "20" "66" "20" "331" "38.2" "5.38" "239.42" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04969, Pf14050, Pf16273" "10726" "ENSG00000090273" "NUDC" "hsa:10726; Q5QP31; Q5QP35; Q9H0N2; Q9Y266; Q9Y2B6" "Ciliary landscape; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; RND2 GTPase cycle" "9" "0" "0.990" "0.992" "0.968" "1.003" "0.937" "1.021" "1.031" "0.960" "0.932" "8939.3" "8852.6" "8866.3" "8657.1" "8965.6" "8372.2" "9122.7" "9219.1" "8581.8" "8333.3" "" "" "" "" "" "" "" "" "" "" "8037.3" "7163.2" "8019.8" "8450.6" "7398.6" "8372.2" "6830.8" "8142.9" "7678.9" "2974.8" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6072286448447602827" "False" "High" "IsMasterProtein" "Q9UBE0" "SUMO-activating enzyme subunit 1 OS=Homo sapiens OX=9606 GN=SAE1 PE=1 SV=1" "0.000" "False" "133.662" "70" "21" "51" "21" "346" "38.4" "5.30" "220.63" "21" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00899" "10055" "ENSG00000142230" "SAE1" "B2RDP5; B3KMQ2; F5GXX7; G3XAK6; hsa:10055; O95717; Q9P020; Q9UBE0" "" "SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "2" "0" "1.018" "1.010" "0.971" "1.022" "0.958" "0.998" "0.990" "0.984" "0.839" "4968.5" "5057.3" "5019.3" "4823.3" "5079.1" "4758.1" "4960.2" "4920.3" "4890.3" "4169.1" "" "" "" "" "" "" "" "" "" "" "4467.2" "4092.2" "4540.1" "4708.2" "4191.4" "4758.1" "3714.0" "4345.9" "4375.8" "1488.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "868843744032576337" "False" "High" "IsMasterProtein" "P48444" "Coatomer subunit delta OS=Homo sapiens OX=9606 GN=ARCN1 PE=1 SV=1" "0.000" "False" "133.647" "46" "23" "58" "23" "511" "57.2" "6.21" "216.91" "23" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf00928, Pf01217" "372" "ENSG00000095139" "ARCN1" "B4E1X2; E9PEU4; hsa:372; P48444; Q52M80" "miR-517 relationship with ARCN1 and USP1" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "1.011" "1.004" "0.990" "0.998" "0.976" "0.999" "1.002" "1.001" "0.819" "5493.0" "5553.0" "5516.6" "5438.1" "5483.6" "5359.6" "5488.6" "5503.1" "5497.7" "4499.4" "" "" "" "" "" "" "" "" "" "" "4938.7" "4493.3" "4989.9" "5308.3" "4525.2" "5359.6" "4109.8" "4860.7" "4919.3" "1606.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6837951581036984725" "False" "High" "IsMasterProtein" "P33241" "Lymphocyte-specific protein 1 OS=Homo sapiens OX=9606 GN=LSP1 PE=1 SV=1" "0.000" "False" "133.385" "69" "15" "76" "15" "339" "37.2" "4.74" "343.90" "15" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton" "cytoskeletal activity" "Pf02029" "4046" "ENSG00000130592; ENSG00000288199" "LSP1" "B3KPP1; B3KRR6; E9PBV6; E9PFP3; hsa:4046; P33241; Q16096; Q53H48; Q6FHM3; Q9BUY8" "" "" "0" "0" "0.921" "0.973" "0.959" "0.958" "0.997" "0.941" "1.019" "1.015" "0.803" "6224.6" "5731.9" "6057.3" "5969.7" "5964.1" "6204.2" "5857.8" "6339.8" "6321.1" "4995.3" "" "" "" "" "" "" "" "" "" "" "5596.5" "4638.0" "5479.0" "5827.2" "4921.7" "6204.2" "4386.1" "5599.7" "5656.0" "1783.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7558389581764573434" "False" "High" "IsMasterProtein" "P18858" "DNA ligase 1 OS=Homo sapiens OX=9606 GN=LIG1 PE=1 SV=1" "0.000" "False" "133.316" "37" "30" "47" "29" "919" "101.7" "5.62" "186.14" "30" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01068, Pf04675, Pf04679" "3978" "ENSG00000105486" "LIG1" "B2RAI8; B4DTU4; hsa:3978; P18858; Q2TB12; Q32P23" "Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Gap-filling DNA repair synthesis and ligation in TC-NER; Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Processive synthesis on the lagging strand; Gap-filling DNA repair synthesis and ligation in GG-NER; Processive synthesis on the C-strand of the telomere; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "14" "0" "1.029" "1.135" "0.989" "0.990" "1.095" "1.087" "0.978" "1.139" "1.495" "4450.1" "4577.7" "5052.8" "4402.6" "4403.6" "4872.2" "4836.5" "4350.4" "5069.6" "6655.0" "" "" "" "" "" "" "" "" "" "" "4001.1" "3704.1" "4570.4" "4297.5" "3633.9" "4872.2" "3621.5" "3842.6" "4536.2" "2375.6" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8527092773428768711" "False" "High" "IsMasterProtein" "Q13561" "Dynactin subunit 2 OS=Homo sapiens OX=9606 GN=DCTN2 PE=1 SV=4" "0.000" "False" "133.250" "65" "22" "54" "22" "401" "44.2" "5.21" "230.32" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04912" "10540" "ENSG00000175203" "DCTN2" "B2RBK5; hsa:10540; Q13561; Q86YN2; Q9BW17" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "0" "1.048" "1.113" "1.075" "1.099" "1.051" "1.145" "1.127" "1.150" "0.954" "4522.7" "4741.2" "5034.4" "4860.4" "4971.9" "4752.7" "5180.6" "5096.8" "5199.4" "4314.6" "" "" "" "" "" "" "" "" "" "" "4066.4" "3836.4" "4553.8" "4744.5" "4102.9" "4752.7" "3879.1" "4501.8" "4652.4" "1540.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93138434393619496" "False" "High" "IsMasterProtein" "Q9NTI5" "Sister chromatid cohesion protein PDS5 homolog B OS=Homo sapiens OX=9606 GN=PDS5B PE=1 SV=1" "0.000" "False" "133.069" "26" "36" "54" "32" "1447" "164.6" "8.47" "199.45" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf20168" "23047" "ENSG00000083642" "PDS5B" "hsa:23047; Q5R3S3; Q5W0K8; Q6NSC3; Q8IXT6; Q9H5N8; Q9NTI5; Q9Y2I5; Q9Y451" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "3" "0.912" "0.954" "0.945" "0.879" "0.919" "0.922" "0.820" "0.840" "1.689" "4775.7" "4357.7" "4555.7" "4513.3" "4199.4" "4390.1" "4404.8" "3916.9" "4012.0" "8064.5" "" "" "" "" "" "" "" "" "" "" "4293.8" "3526.1" "4120.8" "4405.7" "3465.4" "4390.1" "3298.2" "3459.6" "3589.9" "2878.8" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2355880035621835112" "False" "High" "IsMasterProtein" "O15067" "Phosphoribosylformylglycinamidine synthase OS=Homo sapiens OX=9606 GN=PFAS PE=1 SV=4" "0.000" "False" "133.015" "28" "29" "53" "29" "1338" "144.6" "5.76" "191.95" "29" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02769, Pf13507, Pf18072, Pf18076" "5198" "ENSG00000178921" "PFAS" "A6H8V8; hsa:5198; O15067" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.871" "0.830" "0.973" "0.816" "0.766" "0.970" "0.731" "0.788" "1.904" "2526.2" "2200.3" "2097.5" "2456.9" "2061.5" "1934.6" "2451.2" "1846.1" "1990.3" "4809.1" "" "" "" "" "" "" "" "" "" "" "2271.3" "1780.4" "1897.3" "2398.2" "1701.2" "1934.6" "1835.4" "1630.6" "1780.9" "1716.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3973589334991488607" "False" "High" "IsMasterProtein" "Cont_P04264" "Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6" "0.000" "True" "132.854" "37" "27" "47" "21" "644" "66.0" "8.12" "179.31" "27" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208, Pf16210" "3848" "ENSG00000167768" "KRT1" "B2RA01; hsa:3848; P04264; P85925; P86104; Q14720; Q6GSJ0; Q9H298" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Neutrophil degranulation" "4" "5" "0.593" "0.986" "1.252" "0.639" "3.196" "2.100" "1.780" "0.939" "2.228" "3781.7" "2241.7" "3730.2" "4734.3" "2418.0" "12087.2" "7940.0" "6731.8" "3549.6" "8426.3" "" "" "" "" "" "" "" "" "" "" "3400.2" "1813.9" "3374.1" "4621.4" "1995.4" "12087.2" "5945.3" "5945.9" "3176.2" "3007.9" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1520164082407222722" "False" "High" "IsMasterProtein" "P07737" "Profilin-1 OS=Homo sapiens OX=9606 GN=PFN1 PE=1 SV=2" "0.000" "False" "132.205" "75" "13" "288" "13" "140" "15.0" "8.27" "914.96" "13" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5216" "ENSG00000108518" "PFN1" "hsa:5216; P07737; Q53Y44" "Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Burn wound healing; Regulation of actin cytoskeleton; G13 signaling pathway" "RHO GTPases Activate Formins; Platelet degranulation ; PCP/CE pathway; Signaling by ROBO receptors" "9" "0" "1.014" "1.005" "1.085" "1.009" "1.037" "1.030" "1.021" "1.003" "0.810" "15923.0" "16152.3" "16009.3" "17275.0" "16062.0" "16505.5" "16396.1" "16259.2" "15972.9" "12896.5" "" "" "" "" "" "" "" "" "" "" "14316.3" "13069.8" "14481.0" "16862.8" "13254.7" "16505.5" "12277.0" "14361.2" "14292.5" "4603.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630142415015692295" "False" "High" "IsMasterProtein" "P14314" "Glucosidase 2 subunit beta OS=Homo sapiens OX=9606 GN=PRKCSH PE=1 SV=2" "0.000" "False" "132.136" "43" "17" "53" "17" "528" "59.4" "4.41" "206.08" "17" "protein metabolism;other metabolic processes;developmental processes;signal transduction" "ER/Golgi;other cell component" "other molecular function" "Pf12999, Pf13015, Pf13202" "5589" "ENSG00000130175" "PRKCSH" "A8K318; hsa:5589; P14314; Q96BU9; Q96D06; Q9P0W9" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Advanced glycosylation endproduct receptor signaling; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "7" "0" "1.003" "0.993" "0.988" "1.001" "1.104" "1.004" "1.081" "1.021" "0.798" "3809.7" "3820.7" "3781.8" "3765.5" "3814.2" "4204.3" "3825.3" "4117.2" "3888.1" "3040.0" "" "" "" "" "" "" "" "" "" "" "3425.3" "3091.5" "3420.8" "3675.7" "3147.6" "4204.3" "2864.3" "3636.5" "3479.0" "1085.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254798804738061271" "False" "High" "IsMasterProtein" "O60271" "C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens OX=9606 GN=SPAG9 PE=1 SV=4" "0.000" "False" "132.124" "30" "31" "41" "29" "1321" "146.1" "5.15" "162.82" "31" "transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "9043" "ENSG00000008294" "SPAG9" "A6H8U5; A8MSX0; B4DHH2; hsa:9043; O60271; O60905; Q3KQU8; Q3MKM7; Q86WC7; Q86WC8; Q8IZX7; Q96II0; Q9H811" "" "Myogenesis" "1" "2" "1.020" "0.987" "1.021" "1.014" "0.981" "1.006" "0.964" "1.004" "1.154" "3390.8" "3458.2" "3345.9" "3463.4" "3437.5" "3326.4" "3412.3" "3267.2" "3404.1" "3913.0" "" "" "" "" "" "" "" "" "" "" "3048.7" "2798.3" "3026.5" "3380.8" "2836.7" "3326.4" "2555.1" "2885.8" "3046.0" "1396.8" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3038689840563559267" "False" "High" "IsMasterProtein" "Q8WWM7" "Ataxin-2-like protein OS=Homo sapiens OX=9606 GN=ATXN2L PE=1 SV=2" "0.000" "False" "131.845" "30" "27" "60" "26" "1075" "113.3" "8.59" "225.47" "27" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "11273" "ENSG00000168488" "ATXN2L" "A8K1R6; B9EGM2; E9PAR9; hsa:11273; O95135; Q63ZY4; Q6NVJ8; Q6PJW6; Q8IU61; Q8IU95; Q8WWM3; Q8WWM4; Q8WWM5; Q8WWM6; Q8WWM7; Q99703" "16p11.2 distal deletion syndrome" "" "1" "1" "0.962" "0.968" "1.047" "1.004" "0.941" "0.984" "1.052" "0.950" "0.932" "6103.7" "5873.6" "5910.8" "6390.6" "6127.4" "5742.3" "6005.4" "6420.0" "5797.9" "5690.4" "" "" "" "" "" "" "" "" "" "" "5487.8" "4752.7" "5346.6" "6238.2" "5056.4" "5742.3" "4496.7" "5670.6" "5187.9" "2031.3" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6470269132294442760" "False" "High" "IsMasterProtein" "Q8WUM0" "Nuclear pore complex protein Nup133 OS=Homo sapiens OX=9606 GN=NUP133 PE=1 SV=2" "0.000" "False" "131.760" "33" "29" "42" "29" "1156" "128.9" "5.10" "158.16" "29" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03177" "55746" "ENSG00000069248" "NUP133" "B2RAZ8; hsa:55746; Q5T8N0; Q8WUM0; Q9H9W2; Q9NV71; Q9NVC4" "Ciliary landscape" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Regulation of HSF1-mediated heat shock response; HCMV Early Events; tRNA processing in the nucleus; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "36" "0" "1.069" "0.993" "0.956" "1.015" "0.995" "1.027" "1.006" "1.023" "1.058" "3487.8" "3727.6" "3464.5" "3335.4" "3540.2" "3470.1" "3580.8" "3508.5" "3567.6" "3690.1" "" "" "" "" "" "" "" "" "" "" "3135.9" "3016.2" "3133.7" "3255.8" "2921.4" "3470.1" "2681.2" "3098.9" "3192.3" "1317.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428809261446700766" "False" "High" "IsMasterProtein" "Q9UNN5" "FAS-associated factor 1 OS=Homo sapiens OX=9606 GN=FAF1 PE=1 SV=2" "0.000" "False" "131.533" "36" "20" "45" "20" "650" "73.9" "4.88" "181.42" "20" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "11124" "ENSG00000185104" "FAF1" "hsa:11124; Q549F0; Q9UF34; Q9UNN5; Q9UNT3; Q9Y2Z3" "Retinoblastoma gene in cancer; Fas ligand pathway and stress induction of heat shock proteins; VEGFA-VEGFR2 signaling" "" "3" "0" "1.012" "0.969" "1.004" "1.030" "0.937" "1.023" "1.017" "1.000" "0.810" "4453.7" "4506.3" "4316.2" "4470.0" "4587.6" "4174.7" "4556.0" "4530.2" "4451.6" "3606.0" "" "" "" "" "" "" "" "" "" "" "4004.4" "3646.3" "3904.1" "4363.3" "3785.8" "4174.7" "3411.4" "4001.4" "3983.3" "1287.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-253239951813173210" "False" "High" "IsMasterProtein" "Q9H2M9" "Rab3 GTPase-activating protein non-catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP2 PE=1 SV=1" "0.000" "False" "131.492" "27" "32" "50" "31" "1393" "155.9" "5.62" "188.89" "32" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf14655, Pf14656" "25782" "ENSG00000118873" "RAB3GAP2" "A6H8V0; hsa:25782; O75872; Q9H2M9; Q9HAB0; Q9UFJ7; Q9UQ15" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "1" "1.028" "0.986" "0.960" "1.002" "0.961" "1.055" "1.012" "0.991" "1.749" "3287.5" "3378.4" "3240.2" "3154.9" "3294.2" "3159.6" "3468.8" "3326.2" "3259.4" "5748.4" "" "" "" "" "" "" "" "" "" "" "2955.8" "2733.7" "2930.9" "3079.6" "2718.5" "3159.6" "2597.3" "2937.9" "2916.5" "2052.0" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836075231128367811" "False" "High" "IsMasterProtein" "Q15008" "26S proteasome non-ATPase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PSMD6 PE=1 SV=1" "0.000" "False" "131.368" "56" "24" "61" "24" "389" "45.5" "5.62" "226.59" "24" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01399, Pf10602, Pf21154" "9861" "ENSG00000163636" "PSMD6" "A8K2E0; E9PHI9; hsa:9861; Q15008; Q6UV22" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "ABC-family proteins mediated transport; Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Neutrophil degranulation; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.995" "1.011" "1.009" "0.958" "1.014" "0.986" "0.980" "0.998" "0.829" "6155.0" "6122.7" "6223.8" "6213.1" "5893.5" "6238.7" "6067.1" "6033.7" "6140.5" "5104.4" "" "" "" "" "" "" "" "" "" "" "5534.0" "4954.3" "5629.6" "6064.8" "4863.4" "6238.7" "4542.9" "5329.4" "5494.5" "1822.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8832352295829315313" "False" "High" "IsMasterProtein" "P09622" "Dihydrolipoyl dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=DLD PE=1 SV=2" "0.000" "False" "131.311" "43" "18" "72" "18" "509" "54.1" "7.85" "259.41" "18" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02852, Pf07992" "1738" "ENSG00000091140" "DLD" "B2R5X0; B4DHG0; B4DT69; hsa:1738; P09622; Q14131; Q14167; Q59EV8; Q8WTS4" "Fatty acid beta-oxidation; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Tryptophan metabolism; 7q11.23 copy number variation syndrome; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; 10q11.21q11.23 copy number variation syndrome; Metabolic Epileptic Disorders; TCA cycle (aka Krebs or citric acid cycle)" "Lysine catabolism; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Citric acid cycle (TCA cycle); Branched-chain amino acid catabolism; Mitochondrial protein degradation; Glycine degradation" "19" "0" "1.090" "1.059" "1.041" "1.042" "1.085" "1.003" "1.019" "1.061" "0.923" "6973.7" "7604.5" "7387.6" "7261.6" "7269.0" "7565.8" "6994.6" "7103.1" "7400.6" "6434.9" "" "" "" "" "" "" "" "" "" "" "6270.0" "6153.3" "6682.3" "7088.4" "5998.5" "7565.8" "5237.4" "6273.9" "6622.0" "2297.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5365621191326057651" "False" "High" "IsMasterProtein" "P54819" "Adenylate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=AK2 PE=1 SV=2" "0.000" "False" "130.963" "57" "14" "73" "14" "239" "26.5" "7.81" "277.43" "14" "other metabolic processes" "cytoskeleton;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "204" "ENSG00000004455" "AK2" "A8K6L1; B4DHH7; B4DL64; hsa:204; P54819; Q16856; Q5EB54; Q5TIF7; Q8TCY2; Q8TCY3" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.001" "0.954" "1.050" "0.966" "1.049" "0.984" "1.047" "0.960" "0.767" "8559.2" "8564.1" "8162.9" "8988.0" "8272.3" "8975.9" "8422.2" "8961.5" "8214.8" "6561.2" "" "" "" "" "" "" "" "" "" "" "7695.5" "6929.8" "7383.7" "8773.5" "6826.5" "8975.9" "6306.4" "7915.4" "7350.6" "2342.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2799145337949175211" "False" "High" "IsMasterProtein" "O15294" "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Homo sapiens OX=9606 GN=OGT PE=1 SV=3" "0.000" "False" "130.910" "34" "28" "45" "28" "1046" "116.9" "6.70" "182.44" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00515, Pf13181, Pf13414, Pf13424, Pf13844" "8473" "ENSG00000147162" "OGT" "hsa:8473; O15294; Q7Z3K0; Q8WWM8; Q96CC1; Q9UG57" "Ectoderm differentiation; Ectoderm differentiation; Pleural mesothelioma" "UCH proteinases; Regulation of necroptotic cell death; Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "8" "0" "1.027" "0.979" "1.016" "1.031" "1.007" "1.045" "1.034" "0.982" "0.946" "4092.0" "4203.3" "4006.8" "4157.6" "4217.1" "4118.6" "4276.1" "4232.7" "4017.7" "3870.5" "" "" "" "" "" "" "" "" "" "" "3679.1" "3401.2" "3624.3" "4058.4" "3480.1" "4118.6" "3201.8" "3738.6" "3595.0" "1381.6" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996952704107557877" "False" "High" "IsMasterProtein" "P28331" "NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS1 PE=1 SV=3" "0.000" "False" "130.602" "50" "27" "49" "27" "727" "79.4" "6.23" "177.30" "27" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00384, Pf09326, Pf10588, Pf13510" "4719" "ENSG00000023228; ENSG00000283447" "NDUFS1" "B4DIN9; B4DJA0; B4DPG1; B4DUC1; E7ENF3; hsa:4719; P28331; Q53TR8; Q8N1C4; Q8TCC9" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "1.038" "1.074" "1.026" "1.083" "1.078" "1.036" "1.063" "1.064" "0.815" "2759.4" "2865.4" "2963.4" "2831.5" "2989.4" "2974.8" "2859.8" "2933.5" "2937.0" "2249.9" "" "" "" "" "" "" "" "" "" "" "2481.0" "2318.6" "2680.5" "2763.9" "2466.9" "2974.8" "2141.3" "2591.0" "2628.0" "803.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7575182119282234217" "False" "High" "IsMasterProtein" "P18669" "Phosphoglycerate mutase 1 OS=Homo sapiens OX=9606 GN=PGAM1 PE=1 SV=2" "0.000" "False" "130.157" "65" "13" "109" "9" "254" "28.8" "7.18" "409.30" "13" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00300" "5223" "ENSG00000171314" "PGAM1" "hsa:5223; P18669; Q9BWC0" "Cori cycle; Metabolic reprogramming in colon cancer; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis; Gluconeogenesis" "8" "5" "1.066" "1.047" "1.113" "1.066" "1.097" "1.047" "1.037" "1.092" "0.858" "10367.4" "11051.0" "10857.5" "11538.9" "11052.0" "11369.7" "10849.9" "10755.6" "11320.0" "8894.2" "" "" "" "" "" "" "" "" "" "" "9321.3" "8942.0" "9821.0" "11263.6" "9120.3" "11369.7" "8124.1" "9500.1" "10129.1" "3175.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7405730642826192701" "False" "High" "IsMasterProtein" "P00390" "Glutathione reductase, mitochondrial OS=Homo sapiens OX=9606 GN=GSR PE=1 SV=2" "0.000" "False" "129.966" "43" "17" "55" "17" "522" "56.2" "8.50" "248.67" "17" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00070, Pf02852" "2936" "ENSG00000104687" "GSR" "C8KIL8; C8KIL9; C8KIM0; D3DSV3; hsa:2936; P00390; Q7Z5C9; Q9NP63" "Glutathione metabolism; Selenium micronutrient network; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Amino acid metabolism; One-carbon metabolism and related pathways; Oxidative stress response; Vitamin D-sensitive calcium signaling in depression; Sulfation biotransformation reaction; Metapathway biotransformation Phase I and II" "" "11" "0" "1.072" "1.048" "1.133" "1.095" "1.045" "1.067" "0.991" "1.082" "0.853" "4872.6" "5223.5" "5107.0" "5522.1" "5334.7" "5089.6" "5197.4" "4830.8" "5271.5" "4155.0" "" "" "" "" "" "" "" "" "" "" "4380.9" "4226.6" "4619.5" "5390.4" "4402.3" "5089.6" "3891.7" "4266.8" "4716.9" "1483.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4326632445175340721" "False" "High" "IsMasterProtein" "P55209" "Nucleosome assembly protein 1-like 1 OS=Homo sapiens OX=9606 GN=NAP1L1 PE=1 SV=1" "0.000" "False" "129.921" "46" "14" "86" "11" "391" "45.3" "4.46" "363.66" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00956" "4673" "ENSG00000187109" "NAP1L1" "B3KNT8; B3KV44; hsa:4673; P55209" "VEGFA-VEGFR2 signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "" "2" "2" "1.064" "0.993" "1.018" "1.006" "1.092" "0.967" "1.047" "1.030" "0.940" "4572.1" "4862.8" "4541.2" "4656.2" "4600.7" "4994.9" "4422.3" "4788.4" "4707.1" "4299.0" "" "" "" "" "" "" "" "" "" "" "4110.8" "3934.8" "4107.7" "4545.1" "3796.6" "4994.9" "3311.3" "4229.5" "4211.9" "1534.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8980263924004467581" "False" "High" "IsMasterProtein" "P28340" "DNA polymerase delta catalytic subunit OS=Homo sapiens OX=9606 GN=POLD1 PE=1 SV=2" "0.000" "False" "129.884" "36" "34" "42" "33" "1107" "123.6" "7.03" "154.21" "34" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00136, Pf03104, Pf14260" "5424" "ENSG00000062822" "POLD1" "hsa:5424; P28340; Q8NER3; Q96H98" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Progeria-associated lipodystrophy; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "27" "0" "1.063" "0.872" "0.981" "1.085" "0.866" "1.062" "1.035" "0.852" "1.252" "2552.0" "2711.7" "2225.6" "2504.5" "2769.3" "2210.4" "2709.0" "2640.7" "2174.7" "3195.4" "" "" "" "" "" "" "" "" "" "" "2294.5" "2194.2" "2013.2" "2444.8" "2285.2" "2210.4" "2028.4" "2332.5" "1945.9" "1140.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6816817128509432528" "False" "High" "IsMasterProtein" "P10155" "RNA-binding protein RO60 OS=Homo sapiens OX=9606 GN=RO60 PE=1 SV=2" "0.000" "False" "129.691" "46" "23" "50" "23" "538" "60.6" "8.03" "183.90" "23" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05731" "6738" "ENSG00000116747" "RO60" "B2RBB9; hsa:6738; P10155; Q5LJ98; Q5LJ99; Q5LJA0; Q86WL3; Q86WL4; Q92787; Q9H1W6" "" "" "0" "0" "1.011" "0.982" "1.008" "1.057" "0.954" "1.046" "0.984" "1.013" "0.889" "4598.4" "4646.9" "4515.1" "4636.8" "4859.0" "4385.7" "4811.2" "4526.6" "4657.9" "4085.7" "" "" "" "" "" "" "" "" "" "" "4134.4" "3760.1" "4084.1" "4526.1" "4009.7" "4385.7" "3602.5" "3998.2" "4167.9" "1458.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6625268949045148761" "False" "High" "IsMasterProtein" "Q8N163" "Cell cycle and apoptosis regulator protein 2 OS=Homo sapiens OX=9606 GN=CCAR2 PE=1 SV=2" "0.000" "False" "129.678" "34" "26" "47" "26" "923" "102.8" "5.22" "189.64" "26" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14443, Pf14444, Pf19256, Pf19257" "57805" "ENSG00000158941" "CCAR2" "A6NL03; B2RB79; D3DSR6; hsa:57805; Q6P0Q9; Q8N163; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55" "TAR syndrome" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.955" "0.963" "1.035" "0.966" "0.929" "1.052" "0.987" "0.954" "1.583" "3102.4" "2963.3" "2989.1" "3209.5" "2996.4" "2881.5" "3265.0" "3060.6" "2959.0" "4911.7" "" "" "" "" "" "" "" "" "" "" "2789.4" "2397.8" "2703.8" "3133.0" "2472.7" "2881.5" "2444.7" "2703.4" "2647.7" "1753.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-933507358187812304" "False" "High" "IsMasterProtein" "P48634" "Protein PRRC2A OS=Homo sapiens OX=9606 GN=PRRC2A PE=1 SV=3" "0.000" "False" "129.669" "21" "33" "52" "30" "2157" "228.7" "9.45" "167.03" "33" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "" "Pf07001" "7916" "ENSG00000204469; ENSG00000206427; ENSG00000225164; ENSG00000225748; ENSG00000226618; ENSG00000231370; ENSG00000231825" "PRRC2A" "B0UX77; B0UZE9; B0UZL3; hsa:7916; O95875; P48634; Q05BK4; Q4LE37; Q5SQ29; Q5SQ30; Q5ST84; Q5STX6; Q5STX7; Q68DW9; Q6P9P7; Q6PIN1; Q8MGQ9; Q96QC6" "" "" "0" "0" "0.925" "0.933" "0.969" "0.948" "1.074" "0.981" "0.936" "0.903" "0.729" "3538.9" "3274.6" "3301.3" "3428.5" "3354.2" "3799.9" "3472.7" "3311.2" "3195.5" "2580.8" "" "" "" "" "" "" "" "" "" "" "3181.9" "2649.7" "2986.1" "3346.7" "2767.9" "3799.9" "2600.3" "2924.7" "2859.3" "921.3" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4501130865097894528" "False" "High" "IsMasterProtein" "O60763" "General vesicular transport factor p115 OS=Homo sapiens OX=9606 GN=USO1 PE=1 SV=2" "0.000" "False" "129.660" "31" "26" "45" "26" "962" "107.8" "4.91" "173.40" "26" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf04869, Pf04871, Pf18770" "8615" "ENSG00000138768" "USO1" "B2RAQ0; hsa:8615; O60763; Q6PK63; Q86TB8; Q8N592" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Golgi Cisternae Pericentriolar Stack Reorganization" "3" "0" "0.983" "0.997" "0.993" "1.014" "0.996" "0.981" "1.009" "1.020" "0.852" "3220.4" "3164.5" "3211.0" "3198.3" "3266.5" "3208.5" "3160.4" "3249.1" "3284.5" "2744.0" "" "" "" "" "" "" "" "" "" "" "2895.4" "2560.6" "2904.4" "3122.0" "2695.6" "3208.5" "2366.4" "2869.8" "2938.9" "979.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5506725299494211183" "False" "High" "IsMasterProtein" "P25786" "Proteasome subunit alpha type-1 OS=Homo sapiens OX=9606 GN=PSMA1 PE=1 SV=1" "0.000" "False" "129.365" "73" "20" "69" "20" "263" "29.5" "6.61" "265.79" "20" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5682" "ENSG00000129084" "PSMA1" "A8K400; hsa:5682; P25786; Q53YE8; Q9BRV9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "ER-Phagosome pathway; MAPK6/MAPK4 signaling; Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.044" "1.002" "1.033" "1.013" "0.979" "1.028" "1.015" "0.999" "0.788" "6329.8" "6611.2" "6343.3" "6540.1" "6410.2" "6198.8" "6509.3" "6423.0" "6325.4" "4989.3" "" "" "" "" "" "" "" "" "" "" "5691.1" "5349.6" "5737.7" "6384.0" "5289.8" "6198.8" "4874.0" "5673.2" "5659.9" "1781.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4598318327767700223" "False" "High" "IsMasterProtein" "Q96SI9" "Spermatid perinuclear RNA-binding protein OS=Homo sapiens OX=9606 GN=STRBP PE=1 SV=1" "0.000" "False" "129.192" "41" "27" "53" "21" "672" "73.6" "8.72" "184.37" "27" "other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf00035, Pf07528, Pf20965" "55342" "ENSG00000165209" "STRBP" "hsa:55342; Q32NB9; Q96SI9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4" "" "" "0" "0" "1.019" "0.957" "0.960" "0.975" "1.009" "1.038" "0.966" "0.978" "1.210" "3582.5" "3650.6" "3429.4" "3440.7" "3493.3" "3614.2" "3717.7" "3461.1" "3502.4" "4333.4" "" "" "" "" "" "" "" "" "" "" "3221.0" "2954.0" "3102.0" "3358.6" "2882.7" "3614.2" "2783.7" "3057.1" "3133.9" "1546.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4797790429512717329" "False" "High" "IsMasterProtein" "O75874" "Isocitrate dehydrogenase [NADP] cytoplasmic OS=Homo sapiens OX=9606 GN=IDH1 PE=1 SV=2" "0.000" "False" "129.014" "61" "23" "59" "22" "414" "46.6" "7.01" "203.52" "23" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00180" "3417" "ENSG00000138413" "IDH1" "hsa:3417; O75874; Q567U4; Q6FHQ6; Q7Z3V0; Q93090; Q9NTJ9; Q9UKW8" "Glutathione metabolism; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism" "Peroxisomal protein import; Neutrophil degranulation; Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate; NADPH regeneration; NFE2L2 regulating TCA cycle genes" "8" "0" "1.002" "1.007" "0.986" "0.995" "1.003" "1.012" "0.995" "1.008" "0.932" "4351.0" "4361.0" "4383.4" "4288.6" "4329.8" "4365.5" "4404.4" "4330.9" "4385.3" "4054.1" "" "" "" "" "" "" "" "" "" "" "3912.0" "3528.7" "3964.9" "4186.3" "3573.0" "4365.5" "3297.9" "3825.4" "3923.9" "1447.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5340528139668487905" "False" "High" "IsMasterProtein" "O95831" "Apoptosis-inducing factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=AIFM1 PE=1 SV=1" "0.000" "False" "128.843" "35" "18" "53" "18" "613" "66.9" "8.95" "206.01" "18" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00070, Pf14721" "9131" "ENSG00000156709" "AIFM1" "A4QPB4; B1ALN1; B2RB08; D3DTE9; E9PRR0; O95831; Q1L6K4; Q1L6K6; Q2QKE4; Q5JUZ7; Q6I9X6; Q9Y3I3; Q9Y3I4" "Apoptosis modulation and signaling; Nanomaterial induced apoptosis; Apoptosis modulation by HSP70" "" "3" "0" "1.083" "1.059" "1.048" "1.057" "1.026" "0.953" "1.093" "1.112" "0.679" "5913.8" "6404.1" "6261.4" "6194.9" "6253.7" "6067.5" "5635.1" "6461.6" "6576.2" "4013.8" "" "" "" "" "" "" "" "" "" "" "5317.1" "5182.0" "5663.7" "6047.1" "5160.7" "6067.5" "4219.4" "5707.3" "5884.3" "1432.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8725302829576246174" "False" "High" "IsMasterProtein" "P63151" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R2A PE=1 SV=1" "0.000" "False" "128.691" "54" "22" "44" "15" "447" "51.7" "6.20" "192.05" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "" "5520" "ENSG00000221914" "PPP2R2A" "B2RBU8; B4E1T7; hsa:5520; P50409; P63151; Q00007" "Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; Initiation of Nuclear Envelope (NE) Reformation" "7" "6" "0.998" "0.988" "1.049" "1.009" "0.913" "0.971" "0.961" "0.979" "0.873" "4210.4" "4202.8" "4160.9" "4416.6" "4248.6" "3843.6" "4087.8" "4046.7" "4120.3" "3675.5" "" "" "" "" "" "" "" "" "" "" "3785.5" "3400.8" "3763.7" "4311.2" "3506.0" "3843.6" "3060.8" "3574.3" "3686.8" "1312.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117017983706301691" "False" "High" "IsMasterProtein" "P27348" "14-3-3 protein theta OS=Homo sapiens OX=9606 GN=YWHAQ PE=1 SV=1" "0.000" "False" "128.606" "71" "18" "182" "11" "245" "27.7" "4.78" "564.20" "18" "signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00244" "10971" "ENSG00000134308" "YWHAQ" "D6W4Z5; hsa:10971; P27348; Q567U5; Q5TZU8; Q9UP48" "Cell cycle; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Leukocyte-intrinsic Hippo pathway functions; Hepatitis B infection; Opioid receptor pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "19" "1" "0.927" "0.964" "0.987" "0.958" "1.004" "0.976" "1.001" "0.977" "0.798" "8564.1" "7942.6" "8252.3" "8449.5" "8206.8" "8601.5" "8358.0" "8573.8" "8364.5" "6834.7" "" "" "" "" "" "" "" "" "" "" "7699.9" "6426.9" "7464.5" "8247.9" "6772.4" "8601.5" "6258.3" "7572.9" "7484.5" "2439.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5190108194104216904" "False" "High" "IsMasterProtein" "O43615" "Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens OX=9606 GN=TIMM44 PE=1 SV=2" "0.000" "False" "128.597" "50" "24" "54" "24" "452" "51.3" "8.32" "191.38" "24" "transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf04280" "10469" "ENSG00000104980" "TIMM44" "A8K0R9; D6W664; hsa:10469; O43615; Q8N193" "" "Mitochondrial protein import" "1" "0" "1.089" "1.081" "1.008" "1.041" "1.040" "1.054" "1.101" "1.055" "0.897" "5409.2" "5891.9" "5845.2" "5453.7" "5628.4" "5624.2" "5702.4" "5955.7" "5707.9" "4850.5" "" "" "" "" "" "" "" "" "" "" "4863.4" "4767.5" "5287.2" "5323.5" "4644.7" "5624.2" "4269.8" "5260.5" "5107.4" "1731.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4723246947420564514" "False" "High" "IsMasterProtein" "O94915" "Protein furry homolog-like OS=Homo sapiens OX=9606 GN=FRYL PE=1 SV=2" "0.000" "False" "128.330" "13" "36" "47" "35" "3013" "339.4" "5.58" "163.98" "36" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf14222, Pf14225, Pf14228, Pf19421" "285527" "ENSG00000075539" "FRYL" "hsa:285527; O94915; O95640; Q8WTZ5; Q9NT40" "" "" "0" "0" "1.008" "0.961" "0.946" "1.001" "0.951" "0.982" "0.991" "1.017" "0.913" "3815.7" "3845.6" "3665.0" "3611.1" "3817.9" "3629.6" "3745.7" "3781.4" "3879.1" "3484.0" "" "" "" "" "" "" "" "" "" "" "3430.7" "3111.7" "3315.1" "3525.0" "3150.6" "3629.6" "2804.7" "3340.0" "3471.0" "1243.7" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815145421053809259" "False" "High" "IsMasterProtein" "Q16543" "Hsp90 co-chaperone Cdc37 OS=Homo sapiens OX=9606 GN=CDC37 PE=1 SV=1" "0.000" "False" "128.145" "43" "17" "68" "17" "378" "44.4" "5.25" "227.13" "17" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf03234, Pf08564, Pf08565" "11140" "ENSG00000105401" "CDC37" "hsa:11140; Q16543; Q53YA2" "TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Interactions between LOXL4 and oxidative stress pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RHOBTB2 GTPase cycle; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "27" "0" "0.954" "0.977" "1.023" "0.983" "1.009" "0.975" "1.059" "0.978" "0.814" "7830.5" "7473.6" "7653.9" "8008.6" "7695.2" "7898.4" "7631.1" "8293.0" "7655.3" "6377.5" "" "" "" "" "" "" "" "" "" "" "7040.3" "6047.4" "6923.2" "7817.5" "6350.2" "7898.4" "5714.0" "7324.9" "6849.9" "2276.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541335516874274105" "False" "High" "IsMasterProtein" "Q14527" "Helicase-like transcription factor OS=Homo sapiens OX=9606 GN=HLTF PE=1 SV=2" "0.000" "False" "127.935" "37" "32" "44" "32" "1009" "113.9" "8.60" "151.11" "32" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf08797, Pf13923" "6596" "ENSG00000071794" "HLTF" "D3DNH3; Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9" "Retinoblastoma gene in cancer" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "1.069" "1.053" "1.013" "1.030" "1.047" "0.976" "1.097" "1.062" "1.133" "2587.8" "2766.9" "2724.5" "2620.8" "2665.8" "2709.9" "2526.5" "2839.0" "2748.1" "2931.9" "" "" "" "" "" "" "" "" "" "" "2326.7" "2238.9" "2464.4" "2558.3" "2199.8" "2709.9" "1891.8" "2507.6" "2459.0" "1046.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6330757226080927514" "False" "High" "IsMasterProtein" "P67775" "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2CA PE=1 SV=1" "0.000" "False" "127.663" "66" "17" "55" "2" "309" "35.6" "5.54" "233.78" "17" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00149" "5515" "ENSG00000113575" "PPP2CA" "hsa:5515; P05323; P13197; P67775" "Sphingolipid pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Dopamine metabolism; Mesodermal commitment pathway; Mesodermal commitment pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Cancer immunotherapy by CTLA4 blockade; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; DARPP-32 events; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); PKR-mediated signaling; Regulation of TP53 Degradation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Initiation of Nuclear Envelope (NE) Reformation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "53" "0" "0.968" "0.948" "0.973" "1.073" "1.003" "1.041" "0.970" "1.039" "0.851" "477.5" "462.0" "452.6" "464.7" "512.4" "478.7" "496.9" "463.3" "495.9" "406.1" "" "" "" "" "" "" "" "" "" "" "429.3" "373.8" "409.4" "453.7" "422.9" "478.7" "372.0" "409.2" "443.7" "145.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100436114582122401" "False" "High" "IsMasterProtein" "Q93034" "Cullin-5 OS=Homo sapiens OX=9606 GN=CUL5 PE=1 SV=4" "0.000" "False" "127.584" "35" "29" "48" "29" "780" "90.9" "7.94" "169.07" "29" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf00888, Pf10557" "8065" "ENSG00000166266" "CUL5" "A8K960; O14766; Q93034; Q9BZC6" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Dual hijack model of Vif in HIV infection; Modulators of TCR signaling and T cell activation; 10q11.21q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Vif-mediated degradation of APOBEC3G; Neddylation; Downregulation of ERBB2 signaling; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "10" "0" "0.986" "0.965" "0.930" "1.010" "0.939" "0.965" "0.966" "0.981" "0.847" "4768.8" "4703.3" "4599.7" "4433.9" "4817.0" "4476.8" "4601.3" "4604.5" "4676.3" "4039.0" "" "" "" "" "" "" "" "" "" "" "4287.6" "3805.8" "4160.6" "4328.1" "3975.0" "4476.8" "3445.3" "4067.0" "4184.3" "1441.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8291794919948140528" "False" "High" "IsMasterProtein" "Q14203" "Dynactin subunit 1 OS=Homo sapiens OX=9606 GN=DCTN1 PE=1 SV=3" "0.000" "False" "127.562" "29" "28" "36" "28" "1278" "141.6" "5.81" "142.90" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf12455" "1639" "ENSG00000204843" "DCTN1" "A8MY36; B4DM45; E9PFS5; E9PGE1; G5E9H4; hsa:1639; O95296; Q14203; Q6IQ37; Q9BRM9; Q9UIU1; Q9UIU2" "Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; XBP1(S) activates chaperone genes" "8" "0" "0.917" "0.910" "0.957" "0.903" "0.922" "0.994" "0.901" "0.902" "1.599" "2478.3" "2273.1" "2256.2" "2372.1" "2239.0" "2285.5" "2462.3" "2232.4" "2236.0" "3963.4" "" "" "" "" "" "" "" "" "" "" "2228.2" "1839.3" "2040.8" "2315.5" "1847.7" "2285.5" "1843.7" "1971.8" "2000.7" "1414.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8372900262212064526" "False" "High" "IsMasterProtein" "P09651" "Heterogeneous nuclear ribonucleoprotein A1 OS=Homo sapiens OX=9606 GN=HNRNPA1 PE=1 SV=5" "0.000" "False" "127.480" "41" "18" "167" "2" "372" "38.7" "9.13" "622.64" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf11627" "3178" "ENSG00000135486" "HNRNPA1" "A8K4Z8; hsa:3178; P09651; Q3MIB7; Q6PJZ7" "mRNA processing" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1-host interactions; SARS-CoV-1 modulates host translation machinery" "6" "17" "0.992" "0.925" "1.149" "0.989" "1.073" "1.028" "1.029" "0.990" "0.812" "8761.6" "8690.3" "8100.1" "10066.1" "8662.0" "9397.2" "9006.8" "9019.7" "8672.2" "7116.8" "" "" "" "" "" "" "" "" "" "" "7877.5" "7031.9" "7326.8" "9825.9" "7148.1" "9397.2" "6744.1" "7966.8" "7759.8" "2540.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485182549121438413" "False" "High" "IsMasterProtein" "O14776" "Transcription elongation regulator 1 OS=Homo sapiens OX=9606 GN=TCERG1 PE=1 SV=2" "0.000" "False" "127.328" "23" "27" "57" "27" "1098" "123.8" "8.65" "192.12" "27" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00397, Pf01846" "10915" "ENSG00000113649" "TCERG1" "hsa:10915; O14776; Q2NKN2; Q59EA1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.985" "0.953" "1.010" "1.006" "0.981" "1.010" "1.022" "0.945" "1.263" "4769.0" "4698.9" "4542.6" "4818.0" "4797.9" "4678.1" "4815.1" "4872.5" "4504.6" "6024.3" "" "" "" "" "" "" "" "" "" "" "4287.8" "3802.2" "4109.0" "4703.0" "3959.3" "4678.1" "3605.4" "4303.7" "4030.7" "2150.5" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2843591473366045892" "False" "High" "IsMasterProtein" "P62136" "Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CA PE=1 SV=1" "0.000" "False" "127.289" "66" "18" "53" "4" "330" "37.5" "6.33" "226.98" "18" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5499" "ENSG00000172531" "PPP1CA" "A6NNR3; B2R908; hsa:5499; P08129; P20653; P22802; P62136; Q07161" "Sphingolipid pathway; Nicotine effect on dopaminergic neurons; Common pathways underlying drug addiction; Focal adhesion; VEGFA-VEGFR2 signaling; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Netrin-UNC5B signaling pathway; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system" "Triglyceride catabolism; Circadian Clock; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins; DARPP-32 events" "15" "15" "1.035" "1.047" "1.085" "1.062" "1.052" "1.010" "1.022" "1.074" "0.947" "5283.1" "5467.8" "5532.7" "5730.3" "5608.3" "5558.3" "5337.5" "5400.0" "5674.8" "5004.7" "" "" "" "" "" "" "" "" "" "" "4750.0" "4424.3" "5004.6" "5593.6" "4628.0" "5558.3" "3996.6" "4769.6" "5077.7" "1786.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5216339322949848557" "False" "High" "IsMasterProtein" "Q96PZ0" "Pseudouridylate synthase 7 homolog OS=Homo sapiens OX=9606 GN=PUS7 PE=1 SV=2" "0.000" "False" "127.136" "45" "24" "40" "24" "661" "75.0" "6.37" "158.08" "24" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01142" "54517" "ENSG00000091127" "PUS7" "hsa:54517; Q75MG4; Q96PZ0; Q9NX19" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.991" "0.950" "1.008" "1.007" "0.960" "1.028" "1.008" "0.931" "0.989" "3964.7" "3928.2" "3765.3" "3995.1" "3993.0" "3804.9" "4075.2" "3995.4" "3690.6" "3920.5" "" "" "" "" "" "" "" "" "" "" "3564.6" "3178.5" "3405.8" "3899.8" "3295.1" "3804.9" "3051.4" "3529.0" "3302.3" "1399.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5285928462194255524" "False" "High" "IsMasterProtein" "Q9H6T3" "RNA polymerase II-associated protein 3 OS=Homo sapiens OX=9606 GN=RPAP3 PE=1 SV=2" "0.000" "False" "127.110" "44" "27" "38" "27" "665" "75.7" "6.84" "152.71" "27" "other biological processes" "cytosol;other cell component" "" "Pf00515, Pf13181, Pf13877" "79657" "ENSG00000005175" "RPAP3" "B4DRW9; hsa:79657; Q6PHR5; Q9H6T3" "" "" "0" "0" "0.995" "0.975" "0.969" "0.991" "0.989" "0.961" "0.989" "1.002" "1.289" "3845.9" "3824.9" "3748.4" "3727.1" "3812.2" "3805.1" "3697.1" "3804.5" "3854.8" "4956.8" "" "" "" "" "" "" "" "" "" "" "3457.8" "3095.0" "3390.6" "3638.2" "3145.9" "3805.1" "2768.3" "3360.4" "3449.2" "1769.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8769135798573244061" "False" "High" "IsMasterProtein" "P35658" "Nuclear pore complex protein Nup214 OS=Homo sapiens OX=9606 GN=NUP214 PE=1 SV=2" "0.000" "False" "127.065" "16" "25" "38" "25" "2090" "213.5" "7.47" "165.35" "25" "other metabolic processes;transport;other biological processes" "cytosol;nucleus" "other molecular function" "Pf18617" "8021" "ENSG00000126883" "NUP214" "A6NFQ0; hsa:8021; P35658; Q15010; Q3KQZ0; Q5JUP7; Q75R47; Q86XD3" "TGF-beta signaling pathway" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HuR (ELAVL1) binds and stabilizes mRNA" "30" "0" "1.061" "1.097" "1.007" "1.091" "1.212" "1.095" "0.982" "1.170" "1.511" "2827.0" "2998.2" "3101.0" "2846.9" "3084.8" "3426.3" "3095.6" "2777.2" "3306.9" "4270.3" "" "" "" "" "" "" "" "" "" "" "2541.7" "2426.1" "2804.9" "2779.0" "2545.7" "3426.3" "2317.9" "2453.0" "2959.0" "1524.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5545156882891984968" "False" "High" "IsMasterProtein" "P07954" "Fumarate hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=FH PE=1 SV=3" "0.000" "False" "126.779" "49" "19" "47" "19" "510" "54.6" "8.76" "188.83" "19" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00206, Pf10415" "2271" "ENSG00000091483" "FH" "B1ANK7; hsa:2271; P07954" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Krebs cycle disorders; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; TCA cycle in senescence; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "9" "0" "0.964" "1.049" "0.937" "0.984" "0.954" "0.989" "0.967" "0.979" "0.809" "5019.8" "4839.1" "5266.9" "4705.0" "4937.2" "4787.4" "4966.8" "4854.5" "4912.2" "4061.2" "" "" "" "" "" "" "" "" "" "" "4513.3" "3915.6" "4764.1" "4592.8" "4074.3" "4787.4" "3719.0" "4287.8" "4395.4" "1449.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8024352083789976777" "False" "High" "IsMasterProtein" "Q9UKV3" "Apoptotic chromatin condensation inducer in the nucleus OS=Homo sapiens OX=9606 GN=ACIN1 PE=1 SV=2" "0.000" "False" "126.713" "26" "29" "43" "28" "1341" "151.8" "6.43" "166.64" "29" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf16294" "22985" "ENSG00000100813" "ACIN1" "B2RTT4; D3DS45; hsa:22985; O75158; Q9UG91; Q9UKV1; Q9UKV2; Q9UKV3" "" "mRNA Splicing - Major Pathway; Apoptotic cleavage of cellular proteins" "2" "1" "1.052" "0.994" "1.047" "1.125" "1.039" "1.109" "1.040" "0.998" "0.696" "2143.7" "2255.0" "2131.4" "2243.7" "2410.8" "2227.4" "2377.3" "2229.7" "2138.8" "1492.0" "" "" "" "" "" "" "" "" "" "" "1927.4" "1824.7" "1928.0" "2190.2" "1989.4" "2227.4" "1780.0" "1969.4" "1913.8" "532.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "623640857413414358" "False" "High" "IsMasterProtein" "P61981" "14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2" "0.000" "False" "126.685" "71" "18" "184" "12" "247" "28.3" "4.89" "543.06" "18" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00244" "7532" "ENSG00000170027" "YWHAG" "hsa:7532; O70457; P35214; P61981; Q6FH52; Q9UDP2; Q9UN99" "Cell cycle; Prolactin signaling pathway; Myometrial relaxation and contraction pathways; Disruption of postsynaptic signaling by CNV; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; Sudden infant death syndrome (SIDS) susceptibility pathways" "TP53 Regulates Metabolic Genes; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of localization of FOXO transcription factors; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "22" "3" "0.948" "0.971" "1.040" "0.933" "0.967" "0.934" "0.963" "0.950" "0.781" "8003.7" "7583.6" "7768.4" "8320.1" "7463.7" "7738.9" "7477.1" "7710.1" "7600.9" "6247.0" "" "" "" "" "" "" "" "" "" "" "7196.1" "6136.4" "7026.8" "8121.5" "6159.1" "7738.9" "5598.7" "6810.1" "6801.3" "2230.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574312361860662093" "False" "High" "IsMasterProtein" "Q92620" "Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens OX=9606 GN=DHX38 PE=1 SV=2" "0.000" "False" "126.566" "27" "28" "38" "28" "1227" "140.4" "6.54" "145.72" "28" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "9785" "ENSG00000140829" "DHX38" "B4DVG8; D3DWS7; hsa:9785; O75212; Q92620; Q96HN7" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "5" "0" "0.997" "0.991" "0.977" "1.039" "0.992" "1.006" "1.000" "1.012" "1.001" "2898.3" "2891.0" "2872.4" "2831.9" "3011.5" "2874.2" "2915.6" "2898.1" "2933.5" "2899.8" "" "" "" "" "" "" "" "" "" "" "2605.8" "2339.3" "2598.2" "2764.3" "2485.1" "2874.2" "2183.1" "2559.8" "2624.9" "1035.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5554010069989842743" "False" "High" "IsMasterProtein" "Q9BZZ5" "Apoptosis inhibitor 5 OS=Homo sapiens OX=9606 GN=API5 PE=1 SV=3" "0.000" "False" "126.527" "45" "21" "70" "21" "524" "59.0" "7.34" "274.78" "21" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf05918" "8539" "ENSG00000166181" "API5" "B4DGR0; B4DRJ2; B4E283; D3DR21; G3V1C3; hsa:8539; O15441; Q9BZZ5; Q9Y4J7" "" "" "0" "0" "1.015" "1.032" "0.987" "1.030" "1.012" "1.000" "1.015" "1.018" "0.828" "5798.6" "5886.2" "5981.4" "5725.3" "5970.7" "5866.0" "5799.7" "5887.6" "5905.1" "4800.5" "" "" "" "" "" "" "" "" "" "" "5213.6" "4762.9" "5410.4" "5588.7" "4927.2" "5866.0" "4342.7" "5200.3" "5283.9" "1713.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4008936127769007747" "False" "High" "IsMasterProtein" "O43314" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 OS=Homo sapiens OX=9606 GN=PPIP5K2 PE=1 SV=3" "0.000" "False" "126.430" "28" "32" "47" "26" "1243" "140.3" "8.22" "172.94" "32" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "23262" "ENSG00000145725" "PPIP5K2" "A1NI53; A6NGS8; hsa:23262; O43314; Q8TB50" "" "Synthesis of pyrophosphates in the cytosol" "1" "5" "1.055" "1.005" "1.023" "1.026" "0.986" "1.047" "1.028" "1.038" "0.878" "3598.3" "3794.9" "3615.0" "3679.3" "3693.5" "3549.2" "3766.9" "3698.2" "3734.8" "3159.0" "" "" "" "" "" "" "" "" "" "" "3235.2" "3070.7" "3269.9" "3591.5" "3047.9" "3549.2" "2820.5" "3266.5" "3341.9" "1127.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2586862151232699530" "False" "High" "IsMasterProtein" "P07237" "Protein disulfide-isomerase OS=Homo sapiens OX=9606 GN=P4HB PE=1 SV=3" "0.000" "False" "126.354" "46" "25" "70" "25" "508" "57.1" "4.87" "240.45" "25" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00085, Pf13848" "5034" "ENSG00000185624" "P4HB" "B2RDQ2; hsa:5034; P07237; P30037; P32079; Q15205; Q6LDE5" "VEGFA-VEGFR2 signaling; Type I collagen synthesis in the context of osteogenesis imperfecta" "Hedgehog ligand biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; VLDL assembly; LDL remodeling; Collagen biosynthesis and modifying enzymes; Detoxification of Reactive Oxygen Species; Insulin processing; Interleukin-12 signaling; Interleukin-23 signaling" "13" "0" "1.010" "1.066" "1.006" "0.994" "1.019" "0.995" "1.040" "1.036" "0.750" "8716.0" "8806.6" "9289.7" "8767.4" "8663.7" "8881.4" "8669.0" "9060.6" "9030.0" "6532.7" "" "" "" "" "" "" "" "" "" "" "7836.6" "7126.0" "8402.8" "8558.2" "7149.5" "8881.4" "6491.1" "8002.9" "8080.0" "2332.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418505594273786343" "False" "High" "IsMasterProtein" "P48735" "Isocitrate dehydrogenase [NADP], mitochondrial OS=Homo sapiens OX=9606 GN=IDH2 PE=1 SV=2" "0.000" "False" "126.209" "51" "21" "53" "20" "452" "50.9" "8.69" "218.32" "21" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00180" "3418" "ENSG00000182054" "IDH2" "B2R6L6; B4DFL2; hsa:3418; P48735; Q96GT3" "VEGFA-VEGFR2 signaling; Metabolic reprogramming in colon cancer; Cerebral organic acidurias, including diseases; TCA cycle (aka Krebs or citric acid cycle)" "Transcriptional activation of mitochondrial biogenesis; Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "7" "0" "0.997" "1.000" "1.017" "1.000" "0.985" "1.012" "1.012" "1.014" "0.744" "7130.8" "7109.1" "7128.5" "7251.5" "7129.8" "7024.2" "7218.3" "7217.8" "7227.3" "5308.1" "" "" "" "" "" "" "" "" "" "" "6411.3" "5752.4" "6447.9" "7078.5" "5883.6" "7024.2" "5404.8" "6375.2" "6466.9" "1894.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6985960340352969870" "False" "High" "IsMasterProtein" "P62714" "Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP2CB PE=1 SV=1" "0.000" "False" "126.157" "66" "17" "53" "2" "309" "35.6" "5.43" "229.38" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00149" "5516" "ENSG00000104695" "PPP2CB" "D3DSV4; hsa:5516; P11082; P62714; Q6FHK5" "Serotonin transporter activity; Dopamine metabolism; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; Exercise-induced circadian regulation; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; Monoamine transport" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RAF activation; Negative regulation of MAPK pathway; PKR-mediated signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Spry regulation of FGF signaling; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; DARPP-32 events; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "45" "18" "0.990" "1.011" "1.012" "0.995" "1.011" "0.965" "0.957" "0.997" "0.798" "3454.8" "3419.3" "3491.5" "3495.2" "3437.6" "3491.6" "3334.4" "3306.8" "3444.6" "2755.5" "" "" "" "" "" "" "" "" "" "" "3106.2" "2766.8" "3158.1" "3411.8" "2836.7" "3491.6" "2496.7" "2920.8" "3082.2" "983.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535897714363242613" "False" "High" "IsMasterProtein" "Q15019" "Septin-2 OS=Homo sapiens OX=9606 GN=SEPTIN2 PE=1 SV=1" "0.000" "False" "126.056" "68" "20" "53" "19" "361" "41.5" "6.60" "203.55" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00735" "4735" "ENSG00000168385" "SEPTIN2" "B4DGE8; hsa:4735; Q14132; Q15019; Q53QU3; Q8IUK9; Q96CB0" "2q37 copy number variation syndrome" "Anchoring of the basal body to the plasma membrane" "2" "0" "0.988" "0.974" "1.004" "0.986" "0.943" "1.013" "0.994" "0.966" "0.791" "6206.9" "6134.2" "6044.2" "6232.7" "6120.4" "5855.9" "6290.4" "6166.7" "5994.3" "4911.3" "" "" "" "" "" "" "" "" "" "" "5580.6" "4963.6" "5467.2" "6084.0" "5050.6" "5855.9" "4710.1" "5446.8" "5363.7" "1753.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1887782222287180929" "False" "High" "IsMasterProtein" "Q9ULV4" "Coronin-1C OS=Homo sapiens OX=9606 GN=CORO1C PE=1 SV=1" "0.000" "False" "126.028" "42" "26" "66" "25" "474" "53.2" "7.08" "198.99" "26" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "23603" "ENSG00000110880" "CORO1C" "A7MAP0; A7MAP1; B3KU12; hsa:23603; Q9NSK5; Q9ULV4" "" "" "0" "0" "1.006" "1.035" "1.005" "0.983" "1.101" "0.960" "1.017" "1.023" "0.819" "5934.0" "5967.3" "6139.6" "5962.9" "5831.0" "6535.3" "5698.0" "6033.5" "6070.0" "4859.0" "" "" "" "" "" "" "" "" "" "" "5335.2" "4828.5" "5553.5" "5820.6" "4811.8" "6535.3" "4266.5" "5329.1" "5431.4" "1734.5" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2769761607326504072" "False" "High" "IsMasterProtein" "Q9Y3P9" "Rab GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RABGAP1 PE=1 SV=3" "0.000" "False" "125.963" "29" "27" "38" "26" "1069" "121.7" "5.25" "145.96" "27" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00566, Pf00640, Pf12473" "23637" "ENSG00000011454" "RABGAP1" "B9A6L2; hsa:23637; Q05CW2; Q6ZMY1; Q9HA28; Q9P0E2; Q9UG67; Q9Y3P9" "" "TBC/RABGAPs" "1" "1" "0.990" "1.005" "0.981" "1.019" "0.977" "0.992" "1.019" "1.025" "1.054" "4012.1" "3972.0" "4032.6" "3936.4" "4086.7" "3920.4" "3981.8" "4087.0" "4114.1" "4227.4" "" "" "" "" "" "" "" "" "" "" "3607.3" "3214.0" "3647.6" "3842.5" "3372.4" "3920.4" "2981.5" "3609.9" "3681.3" "1509.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6088825967158896660" "False" "High" "IsMasterProtein" "O43290" "U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens OX=9606 GN=SART1 PE=1 SV=1" "0.000" "False" "125.732" "42" "28" "41" "28" "800" "90.2" "6.13" "164.06" "28" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03343, Pf19252" "9092" "ENSG00000175467" "SART1" "A6NDN1; hsa:9092; O43290; Q53GB5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.933" "0.956" "0.934" "1.002" "1.099" "0.992" "0.958" "0.957" "0.666" "3002.1" "2801.1" "2868.5" "2804.5" "3008.7" "3300.5" "2976.9" "2875.5" "2873.7" "1998.9" "" "" "" "" "" "" "" "" "" "" "2699.1" "2266.6" "2594.6" "2737.6" "2482.8" "3300.5" "2229.0" "2539.8" "2571.4" "713.5" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088102652964782572" "False" "High" "IsMasterProtein" "Q13310" "Polyadenylate-binding protein 4 OS=Homo sapiens OX=9606 GN=PABPC4 PE=1 SV=1" "0.000" "False" "125.628" "35" "22" "58" "15" "644" "70.7" "9.26" "216.06" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00658" "8761" "ENSG00000090621" "PABPC4" "B1ANQ8; hsa:8761; Q13310; Q4VC03; Q6P0N3" "" "" "0" "0" "0.982" "0.958" "1.022" "0.993" "0.929" "0.989" "0.999" "0.943" "0.949" "4971.4" "4882.4" "4762.6" "5079.9" "4936.8" "4619.6" "4917.4" "4965.1" "4688.3" "4717.9" "" "" "" "" "" "" "" "" "" "" "4469.8" "3950.7" "4307.9" "4958.7" "4074.0" "4619.6" "3682.1" "4385.5" "4195.1" "1684.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011976368699827672" "False" "High" "IsMasterProtein" "P41091" "Eukaryotic translation initiation factor 2 subunit 3 OS=Homo sapiens OX=9606 GN=EIF2S3 PE=1 SV=3" "0.000" "False" "125.577" "50" "21" "62" "21" "472" "51.1" "8.40" "228.27" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf09173" "1968" "ENSG00000130741" "EIF2S3" "A0A024RBY4; A8K2Y2; B2R5N2; B5BTZ4; hsa:1968; P41091; Q53HK3" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; ABC-family proteins mediated transport; PKR-mediated signaling; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK1 (HRI) to heme deficiency; PERK regulates gene expression; Recycling of eIF2:GDP; Response of EIF2AK4 (GCN2) to amino acid deficiency; Cellular response to mitochondrial stress" "14" "0" "1.033" "1.050" "0.998" "0.988" "0.993" "0.970" "0.994" "1.028" "0.798" "6412.5" "6626.9" "6735.1" "6400.0" "6338.0" "6368.1" "6221.7" "6373.3" "6589.1" "5119.7" "" "" "" "" "" "" "" "" "" "" "5765.5" "5362.3" "6092.2" "6247.3" "5230.2" "6368.1" "4658.6" "5629.3" "5895.9" "1827.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5004824679755995217" "False" "High" "IsMasterProtein" "Q13867" "Bleomycin hydrolase OS=Homo sapiens OX=9606 GN=BLMH PE=1 SV=1" "0.000" "False" "125.457" "49" "17" "50" "17" "455" "52.5" "6.27" "208.24" "17" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03051" "642" "ENSG00000108578" "BLMH" "B2R796; hsa:642; Q13867; Q53F86; Q9UER9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.010" "1.006" "1.045" "1.017" "0.974" "1.012" "1.001" "1.004" "0.755" "5145.5" "5198.4" "5177.7" "5377.6" "5233.0" "5011.5" "5207.8" "5148.7" "5165.4" "3883.8" "" "" "" "" "" "" "" "" "" "" "4626.4" "4206.4" "4683.4" "5249.3" "4318.4" "5011.5" "3899.5" "4547.7" "4622.0" "1386.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5541205227018029514" "False" "High" "IsMasterProtein" "Q9H0P0" "Cytosolic 5'-nucleotidase 3A OS=Homo sapiens OX=9606 GN=NT5C3A PE=1 SV=3" "0.000" "False" "125.416" "54" "17" "48" "17" "336" "37.9" "7.12" "183.38" "17" "other metabolic processes;stress response" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05822" "51251" "ENSG00000122643" "NT5C3A" "A8K253; B2RAA5; B8ZZC4; hsa:51251; Q6IPZ1; Q6NXS6; Q7L3G6; Q9H0P0; Q9P0P5; Q9UC42; Q9UC43; Q9UC44; Q9UC45" "" "" "0" "0" "0.913" "0.957" "0.960" "0.880" "0.888" "0.899" "0.865" "0.942" "1.309" "5604.2" "5119.3" "5361.0" "5378.7" "4932.7" "4978.3" "5036.7" "4847.9" "5279.4" "7333.8" "" "" "" "" "" "" "" "" "" "" "5038.7" "4142.4" "4849.2" "5250.3" "4070.6" "4978.3" "3771.4" "4282.0" "4723.9" "2618.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6199563702112544119" "False" "High" "IsMasterProtein" "Q86XP3" "ATP-dependent RNA helicase DDX42 OS=Homo sapiens OX=9606 GN=DDX42 PE=1 SV=1" "0.000" "False" "125.310" "34" "25" "41" "25" "938" "102.9" "7.02" "166.94" "25" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11325" "ENSG00000198231" "DDX42" "A6NML1; A8KA43; hsa:11325; O75619; Q68G51; Q86XP3; Q96BK1; Q96HR7; Q9Y3V8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "0.969" "0.894" "0.988" "0.967" "0.871" "0.984" "0.928" "0.860" "1.302" "2666.0" "2583.7" "2384.5" "2634.5" "2576.9" "2321.0" "2623.6" "2474.9" "2293.9" "3469.9" "" "" "" "" "" "" "" "" "" "" "2397.0" "2090.6" "2156.9" "2571.7" "2126.5" "2321.0" "1964.5" "2186.0" "2052.6" "1238.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9204758010535676815" "False" "High" "IsMasterProtein" "Q641Q2" "WASH complex subunit 2A OS=Homo sapiens OX=9606 GN=WASHC2A PE=1 SV=3" "0.000" "False" "125.282" "26" "27" "39" "5" "1341" "147.1" "4.81" "154.14" "27" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "387680" "ENSG00000099290" "WASHC2A" "A2A3S2; A2A3U6; hsa:387680; Q5SNT6; Q641Q2; Q6DHY0" "" "" "0" "17" "0.995" "0.995" "1.024" "1.046" "1.001" "1.032" "1.042" "1.052" "1.004" "2981.2" "2966.2" "2966.4" "3051.3" "3119.1" "2985.6" "3077.1" "3105.4" "3136.1" "2993.4" "" "" "" "" "" "" "" "" "" "" "2680.4" "2400.1" "2683.2" "2978.5" "2573.9" "2985.6" "2304.1" "2742.9" "2806.2" "1068.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3283541064302857350" "False" "High" "IsMasterProtein" "O75533" "Splicing factor 3B subunit 1 OS=Homo sapiens OX=9606 GN=SF3B1 PE=1 SV=3" "0.000" "False" "125.091" "28" "30" "45" "30" "1304" "145.7" "7.09" "172.47" "30" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08920" "23451" "ENSG00000115524" "SF3B1" "E9PCH3; hsa:23451; O75533" "mRNA processing; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "5" "0" "0.903" "0.895" "0.954" "0.871" "0.894" "0.983" "0.850" "0.796" "1.284" "2989.1" "2700.6" "2676.2" "2851.0" "2602.0" "2671.4" "2939.1" "2541.7" "2380.8" "3839.1" "" "" "" "" "" "" "" "" "" "" "2687.5" "2185.2" "2420.7" "2783.0" "2147.3" "2671.4" "2200.7" "2245.0" "2130.3" "1370.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "419048109363271085" "False" "High" "IsMasterProtein" "Q10713" "Mitochondrial-processing peptidase subunit alpha OS=Homo sapiens OX=9606 GN=PMPCA PE=1 SV=2" "0.000" "False" "124.615" "51" "22" "44" "22" "525" "58.2" "6.92" "174.32" "22" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "23203" "ENSG00000165688" "PMPCA" "B4DKL3; E7ET61; hsa:23203; Q10713; Q16639; Q5SXM9; Q8N513" "" "Mitochondrial protein import; Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "0.979" "0.997" "0.958" "0.978" "0.925" "0.962" "0.964" "0.995" "0.815" "5278.4" "5165.7" "5263.6" "5056.7" "5162.7" "4883.5" "5080.3" "5087.2" "5249.7" "4301.1" "" "" "" "" "" "" "" "" "" "" "4745.8" "4179.9" "4761.1" "4936.1" "4260.4" "4883.5" "3804.0" "4493.3" "4697.4" "1535.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144982604897555779" "False" "High" "IsMasterProtein" "P52306" "Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens OX=9606 GN=RAP1GDS1 PE=1 SV=3" "0.000" "False" "124.498" "43" "23" "46" "21" "607" "66.3" "5.31" "174.70" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus" "enzyme regulator activity" "Pf00514" "5910" "ENSG00000138698" "RAP1GDS1" "E9PH06; G5E9P9; hsa:5910; P52306; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8" "" "RHOT2 GTPase cycle; RHOT1 GTPase cycle" "2" "0" "1.001" "1.012" "0.953" "1.003" "0.935" "1.006" "0.997" "0.961" "1.085" "4453.9" "4459.0" "4506.9" "4246.4" "4467.3" "4163.7" "4479.4" "4439.5" "4280.6" "4831.8" "" "" "" "" "" "" "" "" "" "" "4004.5" "3608.1" "4076.7" "4145.1" "3686.5" "4163.7" "3354.0" "3921.2" "3830.2" "1724.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3364177795992672609" "False" "High" "IsMasterProtein" "P42765" "3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAA2 PE=1 SV=2" "0.000" "False" "124.482" "61" "19" "57" "19" "397" "41.9" "8.09" "229.09" "19" "cell organization and biogenesis;other metabolic processes;stress response;transport" "mitochondrion" "other molecular function" "Pf00108, Pf02803" "10449" "ENSG00000167315" "ACAA2" "hsa:10449; P42765; Q9BUT6" "Fatty acid biosynthesis" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "0.976" "0.943" "1.027" "0.948" "1.001" "0.954" "0.993" "0.983" "0.770" "4557.5" "4449.4" "4298.3" "4681.7" "4319.2" "4560.8" "4349.2" "4524.4" "4480.9" "3507.6" "" "" "" "" "" "" "" "" "" "" "4097.6" "3600.3" "3888.0" "4570.0" "3564.3" "4560.8" "3256.6" "3996.2" "4009.5" "1252.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468069501493151827" "False" "High" "IsMasterProtein" "P37837" "Transaldolase OS=Homo sapiens OX=9606 GN=TALDO1 PE=1 SV=2" "0.000" "False" "124.459" "52" "21" "65" "21" "337" "37.5" "6.81" "228.90" "21" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00923" "6888" "ENSG00000177156" "TALDO1" "B2R8M2; hsa:6888; O00751; P37837; Q8WV32; Q8WZ45" "Pentose phosphate metabolism; Cori cycle; Metabolic reprogramming in colon cancer" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; NFE2L2 regulates pentose phosphate pathway genes; Pentose phosphate pathway; Insulin effects increased synthesis of Xylulose-5-Phosphate; TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P; TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P" "9" "0" "0.977" "0.998" "1.022" "0.950" "0.976" "0.995" "0.982" "0.945" "0.900" "11228.9" "10966.7" "11210.3" "11479.7" "10666.9" "10957.4" "11176.8" "11025.7" "10614.7" "10107.4" "" "" "" "" "" "" "" "" "" "" "10095.9" "8873.9" "10140.1" "11205.8" "8802.5" "10957.4" "8368.9" "9738.6" "9498.0" "3608.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828229649447777005" "False" "High" "IsMasterProtein" "P31153" "S-adenosylmethionine synthase isoform type-2 OS=Homo sapiens OX=9606 GN=MAT2A PE=1 SV=1" "0.000" "False" "124.445" "57" "20" "64" "20" "395" "43.6" "6.48" "244.85" "20" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00438, Pf02772, Pf02773" "4144" "ENSG00000168906" "MAT2A" "A8K511; B4DN45; D6W5L1; hsa:4144; P31153; Q53SP5" "Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; One-carbon metabolism and related pathways; Methylation pathways" "Methylation" "5" "0" "1.023" "1.030" "1.011" "0.989" "0.984" "1.024" "1.000" "1.041" "0.818" "6798.9" "6957.7" "7000.9" "6870.5" "6723.1" "6691.5" "6962.9" "6799.9" "7078.4" "5559.6" "" "" "" "" "" "" "" "" "" "" "6112.9" "5629.9" "6332.5" "6706.6" "5548.0" "6691.5" "5213.6" "6006.1" "6333.7" "1984.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365252663665012706" "False" "High" "IsMasterProtein" "P49589" "Cysteine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=CARS1 PE=1 SV=3" "0.000" "False" "124.286" "35" "24" "42" "24" "748" "85.4" "6.76" "167.03" "24" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01406" "833" "ENSG00000110619; ENSG00000278191" "CARS1" "hsa:833; P49589; Q53XI8; Q5HYE4; Q9HD24; Q9HD25" "" "Signaling by ALK fusions and activated point mutants; Cytosolic tRNA aminoacylation" "2" "0" "1.015" "1.024" "0.990" "1.026" "1.012" "1.010" "0.988" "0.984" "0.842" "4340.5" "4404.1" "4444.7" "4295.2" "4452.6" "4394.7" "4385.3" "4287.2" "4272.7" "3653.7" "" "" "" "" "" "" "" "" "" "" "3902.5" "3563.6" "4020.4" "4192.7" "3674.3" "4394.7" "3283.6" "3786.7" "3823.2" "1304.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543503445909431130" "False" "High" "IsMasterProtein" "P13798" "Acylamino-acid-releasing enzyme OS=Homo sapiens OX=9606 GN=APEH PE=1 SV=4" "0.000" "False" "124.238" "37" "21" "48" "21" "732" "81.2" "5.48" "180.82" "21" "cell organization and biogenesis;protein metabolism;other metabolic processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf19283" "327" "ENSG00000164062" "APEH" "hsa:327; P13798; Q9BQ33; Q9P0Y2" "" "Neutrophil degranulation; Eukaryotic Translation Termination" "2" "0" "1.044" "1.013" "1.009" "1.038" "1.004" "1.008" "0.972" "1.037" "0.834" "4082.1" "4261.1" "4136.2" "4120.0" "4238.7" "4098.5" "4112.9" "3967.2" "4231.6" "3406.3" "" "" "" "" "" "" "" "" "" "" "3670.2" "3448.0" "3741.3" "4021.7" "3497.9" "4098.5" "3079.6" "3504.1" "3786.4" "1215.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561632737835215968" "False" "High" "IsMasterProtein" "A8MVU1" "Putative neutrophil cytosol factor 1C OS=Homo sapiens OX=9606 GN=NCF1C PE=5 SV=1" "0.000" "False" "124.172" "59" "20" "66" "1" "366" "41.8" "8.84" "250.78" "20" "other metabolic processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00787, Pf08944, Pf16621" "" "" "NCF1C" "A8MVU1" "" "" "0" "0" "0.962" "0.934" "0.892" "0.985" "0.950" "0.935" "0.927" "0.984" "1.036" "258.5" "248.6" "241.6" "230.6" "254.6" "245.7" "241.7" "239.7" "254.5" "267.8" "" "" "" "" "" "" "" "" "" "" "232.4" "201.2" "218.5" "225.1" "210.1" "245.7" "180.9" "211.7" "227.7" "95.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6253369152743795153" "False" "High" "IsMasterProtein" "Q8TD16" "Protein bicaudal D homolog 2 OS=Homo sapiens OX=9606 GN=BICD2 PE=1 SV=1" "0.000" "False" "124.003" "38" "29" "40" "23" "824" "93.5" "5.44" "157.34" "29" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf09730" "23299" "ENSG00000185963" "BICD2" "hsa:23299; O75181; Q5TBQ2; Q5TBQ3; Q8TD16; Q96LH2; Q9BT84; Q9H561" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "5" "1.013" "1.051" "0.963" "1.032" "1.041" "1.035" "1.024" "1.078" "1.017" "3034.9" "3073.7" "3189.4" "2923.0" "3131.5" "3158.8" "3140.8" "3106.6" "3273.1" "3086.5" "" "" "" "" "" "" "" "" "" "" "2728.6" "2487.1" "2885.0" "2853.3" "2584.2" "3158.8" "2351.7" "2744.0" "2928.7" "1101.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549742544018315320" "False" "High" "IsMasterProtein" "O14744" "Protein arginine N-methyltransferase 5 OS=Homo sapiens OX=9606 GN=PRMT5 PE=1 SV=4" "0.000" "False" "123.758" "46" "25" "52" "25" "637" "72.6" "6.29" "188.10" "25" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05185, Pf17285, Pf17286" "10419" "ENSG00000100462" "PRMT5" "A8MTP3; A8MZ91; B4DX49; B4DY30; B5BU10; D3DS33; E2QRE7; hsa:10419; O14744; Q6IBR1; Q9UKH1" "Transcription co-factors SKI and SKIL protein partners; Nitric oxide metabolism in cystic fibrosis" "snRNP Assembly; RMTs methylate histone arginines; Regulation of TP53 Activity through Methylation" "5" "0" "0.994" "0.971" "0.978" "0.991" "0.923" "0.944" "0.970" "0.967" "0.731" "4442.6" "4414.2" "4315.4" "4342.8" "4402.3" "4101.9" "4194.0" "4308.9" "4297.9" "3248.8" "" "" "" "" "" "" "" "" "" "" "3994.3" "3571.8" "3903.4" "4239.2" "3632.8" "4101.9" "3140.3" "3805.9" "3845.7" "1159.7" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8973265240341480372" "False" "High" "IsMasterProtein" "Q06203" "Amidophosphoribosyltransferase OS=Homo sapiens OX=9606 GN=PPAT PE=1 SV=1" "0.000" "False" "123.756" "45" "20" "53" "20" "517" "57.4" "6.76" "198.85" "20" "other metabolic processes" "cytosol" "other molecular function" "Pf00156, Pf13522" "5471" "ENSG00000128059" "PPAT" "hsa:5471; Q06203" "Fluoropyrimidine activity; Metabolic reprogramming in colon cancer" "Purine ribonucleoside monophosphate biosynthesis" "3" "0" "0.997" "0.986" "0.991" "1.021" "0.969" "0.968" "0.990" "1.006" "0.765" "4990.4" "4975.2" "4918.5" "4943.3" "5093.5" "4836.0" "4830.0" "4938.0" "5018.1" "3819.2" "" "" "" "" "" "" "" "" "" "" "4486.9" "4025.8" "4449.0" "4825.4" "4203.2" "4836.0" "3616.6" "4361.6" "4490.1" "1363.4" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5870318523395655526" "False" "High" "IsMasterProtein" "P49591" "Serine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=SARS1 PE=1 SV=3" "0.000" "False" "123.462" "48" "22" "57" "22" "514" "58.7" "6.43" "219.67" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02403" "6301" "ENSG00000031698" "SARS1" "B2R6Y9; hsa:6301; P49591; Q5T5C8; Q9NSE3" "VEGFA-VEGFR2 signaling" "Selenocysteine synthesis; Cytosolic tRNA aminoacylation" "3" "0" "0.977" "1.002" "0.974" "1.007" "0.976" "1.011" "0.988" "0.958" "0.802" "4977.9" "4865.9" "4989.9" "4848.9" "5011.8" "4857.0" "5030.4" "4919.5" "4767.2" "3991.2" "" "" "" "" "" "" "" "" "" "" "4475.7" "3937.3" "4513.6" "4733.2" "4135.8" "4857.0" "3766.6" "4345.2" "4265.6" "1424.8" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337219862284108106" "False" "High" "IsMasterProtein" "Q9Y262" "Eukaryotic translation initiation factor 3 subunit L OS=Homo sapiens OX=9606 GN=EIF3L PE=1 SV=1" "0.000" "False" "123.347" "41" "23" "48" "23" "564" "66.7" "6.34" "179.89" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf10255" "51386" "ENSG00000100129" "EIF3L" "B2RDG6; B4DYB2; G8JLH4; hsa:51386; Q53HQ1; Q53HT4; Q5QTR1; Q5TI15; Q6ICD2; Q9Y262" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "6" "0" "0.985" "1.022" "0.965" "0.989" "1.004" "0.964" "0.973" "0.989" "0.959" "5375.2" "5293.9" "5494.4" "5187.7" "5314.3" "5394.9" "5184.1" "5231.3" "5314.8" "5153.9" "" "" "" "" "" "" "" "" "" "" "4832.8" "4283.6" "4969.8" "5063.9" "4385.4" "5394.9" "3881.7" "4620.6" "4755.7" "1839.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4060364465058462245" "False" "High" "IsMasterProtein" "Q15435" "Protein phosphatase 1 regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PPP1R7 PE=1 SV=1" "0.000" "False" "123.259" "57" "19" "54" "19" "360" "41.5" "4.91" "192.68" "19" "other biological processes" "other cell component" "enzyme regulator activity" "Pf12799, Pf14580" "5510" "ENSG00000115685" "PPP1R7" "B4DFD4; B5MCY6; hsa:5510; Q15435; Q9UQE5; Q9UQE6; Q9Y6K4" "2q37 copy number variation syndrome" "" "1" "0" "0.961" "0.933" "1.002" "1.022" "0.959" "1.053" "0.997" "0.990" "0.864" "3457.3" "3321.3" "3226.4" "3462.7" "3533.4" "3315.0" "3641.8" "3447.8" "3424.0" "2988.3" "" "" "" "" "" "" "" "" "" "" "3108.5" "2687.5" "2918.4" "3380.1" "2915.8" "3315.0" "2726.9" "3045.3" "3063.7" "1066.7" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986296192720168781" "False" "High" "IsMasterProtein" "Q9Y617" "Phosphoserine aminotransferase OS=Homo sapiens OX=9606 GN=PSAT1 PE=1 SV=2" "0.000" "False" "122.965" "61" "21" "56" "21" "370" "40.4" "7.66" "202.11" "21" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00266" "29968" "ENSG00000135069" "PSAT1" "hsa:29968; Q5T7G5; Q5T7G6; Q96AW2; Q9BQ12; Q9Y617" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Male infertility; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "7" "0" "1.045" "1.015" "1.058" "1.013" "1.002" "1.000" "1.010" "1.036" "0.785" "5261.8" "5500.0" "5339.7" "5566.8" "5329.3" "5271.8" "5259.3" "5316.9" "5453.2" "4131.7" "" "" "" "" "" "" "" "" "" "" "4730.9" "4450.4" "4829.9" "5433.9" "4397.9" "5271.8" "3938.0" "4696.2" "4879.5" "1474.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211102690049465357" "False" "High" "IsMasterProtein" "P11310" "Medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADM PE=1 SV=1" "0.000" "False" "122.924" "52" "21" "76" "21" "421" "46.6" "8.37" "306.79" "21" "other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771" "34" "ENSG00000117054" "ACADM" "hsa:34; P11310; Q5T4U4; Q9NYF1" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; PPAR signaling pathway; Mitochondrial fatty acid oxidation disorders; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA" "13" "0" "0.999" "0.985" "1.018" "0.944" "0.953" "0.964" "0.991" "0.967" "0.770" "7221.8" "7213.5" "7113.2" "7352.5" "6816.4" "6884.2" "6963.7" "7156.9" "6980.9" "5562.0" "" "" "" "" "" "" "" "" "" "" "6493.1" "5836.9" "6434.2" "7177.0" "5625.0" "6884.2" "5214.3" "6321.4" "6246.5" "1985.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6465314109903613014" "False" "High" "IsMasterProtein" "Q99615" "DnaJ homolog subfamily C member 7 OS=Homo sapiens OX=9606 GN=DNAJC7 PE=1 SV=2" "0.000" "False" "122.870" "51" "25" "50" "25" "494" "56.4" "6.96" "164.82" "25" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00226" "7266" "ENSG00000168259" "DNAJC7" "hsa:7266; Q7Z784; Q99615" "Constitutive androstane receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway" "Regulation of HSF1-mediated heat shock response" "4" "0" "0.932" "0.955" "0.986" "0.939" "0.913" "0.938" "0.943" "0.945" "1.111" "4830.6" "4499.8" "4614.7" "4764.8" "4537.6" "4409.8" "4533.0" "4554.9" "4565.5" "5367.3" "" "" "" "" "" "" "" "" "" "" "4343.2" "3641.1" "4174.1" "4651.1" "3744.5" "4409.8" "3394.2" "4023.2" "4085.2" "1916.0" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7944368975479606522" "False" "High" "IsMasterProtein" "O94979" "Protein transport protein Sec31A OS=Homo sapiens OX=9606 GN=SEC31A PE=1 SV=3" "0.000" "False" "122.791" "24" "29" "43" "29" "1220" "132.9" "6.89" "161.33" "29" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf12931" "22872" "ENSG00000138674" "SEC31A" "B4DIW6; B7ZKZ7; B7ZL00; H7C2W3; hsa:22872; O94979; Q17RR5; Q5H9P6; Q5XG74; Q659G7; Q6ZU90; Q7LCX9; Q86TJ0; Q8IZH4; Q9P048; Q9P0A6; Q9UM05; Q9UM06" "Sterol regulatory element-binding proteins (SREBP) signaling" "Signaling by ALK fusions and activated point mutants; MHC class II antigen presentation; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "6" "0" "1.025" "1.075" "0.994" "1.049" "1.047" "1.034" "1.007" "1.038" "1.314" "4742.2" "4858.6" "5096.1" "4714.1" "4976.2" "4963.0" "4905.0" "4776.7" "4923.0" "6231.6" "" "" "" "" "" "" "" "" "" "" "4263.7" "3931.4" "4609.6" "4601.6" "4106.4" "4963.0" "3672.7" "4219.1" "4405.1" "2224.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866908035804814240" "False" "High" "IsMasterProtein" "P22059" "Oxysterol-binding protein 1 OS=Homo sapiens OX=9606 GN=OSBP PE=1 SV=1" "0.000" "False" "122.463" "42" "27" "45" "27" "807" "89.4" "7.30" "174.09" "27" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "5007" "ENSG00000110048" "OSBP" "hsa:5007; P22059; Q6P524" "" "Sphingolipid de novo biosynthesis; Synthesis of bile acids and bile salts" "2" "0" "1.007" "1.001" "0.993" "0.998" "0.964" "0.994" "0.997" "1.005" "0.810" "3946.4" "3974.2" "3951.5" "3920.6" "3940.2" "3803.2" "3923.2" "3936.4" "3966.7" "3195.4" "" "" "" "" "" "" "" "" "" "" "3548.2" "3215.8" "3574.2" "3827.1" "3251.6" "3803.2" "2937.6" "3476.9" "3549.4" "1140.7" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124389197736880790" "False" "High" "IsMasterProtein" "P40925" "Malate dehydrogenase, cytoplasmic OS=Homo sapiens OX=9606 GN=MDH1 PE=1 SV=4" "0.000" "False" "122.379" "56" "23" "98" "23" "334" "36.4" "7.36" "320.07" "23" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00056, Pf02866" "4190" "ENSG00000014641" "MDH1" "B2R5V5; B4DUN2; B7Z3I7; F5H098; hsa:4190; P40925; Q6I9V0" "Sterol regulatory element-binding proteins (SREBP) signaling; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Clear cell renal cell carcinoma pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; HDAC6 interactions in the central nervous system" "Gluconeogenesis" "10" "0" "1.041" "1.074" "1.085" "1.005" "1.136" "1.036" "1.013" "1.066" "0.789" "10348.5" "10770.4" "11109.7" "11227.9" "10403.0" "11759.4" "10719.0" "10482.6" "11034.4" "8166.1" "" "" "" "" "" "" "" "" "" "" "9304.4" "8715.0" "10049.1" "10960.0" "8584.8" "11759.4" "8026.1" "9258.9" "9873.5" "2915.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1728322554936911435" "False" "High" "IsMasterProtein" "Q14978" "Nucleolar and coiled-body phosphoprotein 1 OS=Homo sapiens OX=9606 GN=NOLC1 PE=1 SV=2" "0.000" "False" "122.296" "45" "28" "58" "28" "699" "73.6" "9.47" "194.48" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05022" "9221" "ENSG00000166197" "NOLC1" "hsa:9221; Q14978; Q15030; Q5VV70; Q9BUV3" "" "" "0" "0" "0.956" "0.896" "0.864" "0.841" "1.236" "0.863" "0.965" "0.807" "0.557" "5542.6" "5296.2" "4968.8" "4789.6" "4662.5" "6848.3" "4785.6" "5346.1" "4472.2" "3088.9" "" "" "" "" "" "" "" "" "" "" "4983.3" "4285.5" "4494.4" "4675.3" "3847.6" "6848.3" "3583.3" "4722.1" "4001.7" "1102.6" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7326537803977903766" "False" "High" "IsMasterProtein" "P02786" "Transferrin receptor protein 1 OS=Homo sapiens OX=9606 GN=TFRC PE=1 SV=2" "0.000" "False" "121.927" "41" "27" "40" "27" "760" "84.8" "6.61" "156.01" "27" "stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf02225, Pf04253, Pf04389" "7037" "ENSG00000072274" "TFRC" "D3DXB0; hsa:7037; P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21" "Iron metabolism in placenta; Ferroptosis; 3q29 copy number variation syndrome; Iron metabolism disorders" "RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; Golgi Associated Vesicle Biogenesis; RND1 GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; Transferrin endocytosis and recycling; RHOH GTPase cycle" "21" "0" "1.032" "1.060" "1.019" "1.003" "1.001" "1.030" "1.038" "1.082" "0.715" "4477.1" "4622.6" "4745.6" "4564.3" "4488.3" "4483.7" "4612.3" "4649.2" "4846.2" "3202.5" "" "" "" "" "" "" "" "" "" "" "4025.4" "3740.4" "4292.6" "4455.4" "3703.9" "4483.7" "3453.6" "4106.5" "4336.3" "1143.2" "28" "28" "28" "28" "28" "28" "28" "28" "28" "28" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6733467377289635687" "False" "High" "IsMasterProtein" "Q13838" "Spliceosome RNA helicase DDX39B OS=Homo sapiens OX=9606 GN=DDX39B PE=1 SV=1" "0.000" "False" "121.868" "45" "20" "74" "8" "428" "49.0" "5.67" "243.52" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "7919" "ENSG00000198563; ENSG00000215425; ENSG00000225073; ENSG00000225859; ENSG00000229496; ENSG00000230624; ENSG00000235439" "DDX39B" "B0S8C0; hsa:7919; O43496; Q0EFA1; Q13838; Q2L6F9; Q53GL9; Q5RJ64; Q5RJ66; Q5ST94; Q5STB4; Q5STB5; Q5STB7; Q5STB8; Q5STU4; Q5STU5; Q5STU6; Q5STU8; Q71V76" "" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RHOBTB2 GTPase cycle" "5" "13" "1.053" "1.021" "1.026" "1.083" "0.979" "1.074" "1.055" "1.008" "1.056" "6248.3" "6578.6" "6379.3" "6409.8" "6765.7" "6117.3" "6710.4" "6590.4" "6298.1" "6597.3" "" "" "" "" "" "" "" "" "" "" "5617.9" "5323.1" "5770.3" "6256.9" "5583.1" "6117.3" "5024.6" "5821.0" "5635.5" "2355.1" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4912222715256496910" "False" "High" "IsMasterProtein" "O43390" "Heterogeneous nuclear ribonucleoprotein R OS=Homo sapiens OX=9606 GN=HNRNPR PE=1 SV=1" "0.000" "False" "121.841" "41" "23" "53" "14" "633" "70.9" "8.13" "193.70" "23" "RNA metabolism OR transcription;other metabolic processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf18360" "10236" "ENSG00000125944; ENSG00000282958" "HNRNPR" "hsa:10236; O43390; Q2L7G6; Q5TEH1; Q9BV64; S4R3J4" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "0.989" "0.939" "0.887" "1.007" "1.025" "0.947" "0.938" "0.877" "1.487" "2159.8" "2135.0" "2027.3" "1914.9" "2175.9" "2214.8" "2046.0" "2026.3" "1894.2" "3211.1" "" "" "" "" "" "" "" "" "" "" "1941.8" "1727.6" "1833.7" "1869.2" "1795.6" "2214.8" "1532.0" "1789.8" "1694.9" "1146.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6979633451004201219" "False" "High" "IsMasterProtein" "P31946" "14-3-3 protein beta/alpha OS=Homo sapiens OX=9606 GN=YWHAB PE=1 SV=3" "0.000" "False" "121.619" "69" "15" "204" "7" "246" "28.1" "4.83" "636.71" "15" "signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "7529" "ENSG00000166913" "YWHAB" "A8K9K2; E1P616; hsa:7529; P31946" "Cell cycle; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Hepatitis B infection; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Signaling by Hippo; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Rap1 signalling; Negative regulation of MAPK pathway; Frs2-mediated activation; ARMS-mediated activation; Activation of BAD and translocation to mitochondria ; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "33" "0" "0.891" "0.929" "0.947" "0.970" "0.924" "0.942" "0.995" "0.966" "0.758" "3327.0" "2963.7" "3089.9" "3150.0" "3227.3" "3074.0" "3133.0" "3308.9" "3215.0" "2522.5" "" "" "" "" "" "" "" "" "" "" "2991.3" "2398.1" "2795.0" "3074.9" "2663.2" "3074.0" "2345.9" "2922.6" "2876.8" "900.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5428916693947129614" "False" "High" "IsMasterProtein" "Q92556" "Engulfment and cell motility protein 1 OS=Homo sapiens OX=9606 GN=ELMO1 PE=1 SV=2" "0.000" "False" "121.570" "45" "30" "47" "29" "727" "83.8" "6.28" "163.50" "30" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf04727, Pf11841, Pf16457" "9844" "ENSG00000155849" "ELMO1" "A4D1X6; hsa:9844; Q29R79; Q6ZTJ0; Q92556; Q96PB0; Q9H0I1" "Chemokine signaling pathway; CCL18 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction" "7" "1" "1.017" "0.980" "0.992" "1.017" "0.927" "1.050" "1.006" "0.954" "1.012" "5003.8" "5086.8" "4903.2" "4961.4" "5087.0" "4637.2" "5253.4" "5035.9" "4771.5" "5064.1" "" "" "" "" "" "" "" "" "" "" "4498.9" "4116.1" "4435.1" "4843.0" "4197.9" "4637.2" "3933.6" "4448.1" "4269.5" "1807.7" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563058972091496350" "False" "High" "IsMasterProtein" "P80723" "Brain acid soluble protein 1 OS=Homo sapiens OX=9606 GN=BASP1 PE=1 SV=2" "0.000" "False" "121.509" "82" "15" "35" "15" "227" "22.7" "4.63" "183.07" "15" "developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05466" "10409" "ENSG00000176788" "BASP1" "B4DJA8; D3DTD5; hsa:10409; O43596; P80723; Q5U0S0; Q9BWA5" "" "RHOF GTPase cycle" "1" "0" "0.931" "0.915" "0.991" "0.844" "0.967" "0.894" "0.950" "0.899" "0.747" "5019.6" "4673.5" "4592.0" "4974.9" "4234.6" "4853.6" "4489.3" "4770.6" "4514.1" "3748.9" "" "" "" "" "" "" "" "" "" "" "4513.1" "3781.7" "4153.6" "4856.2" "3494.5" "4853.6" "3361.5" "4213.7" "4039.2" "1338.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2537127350626285919" "False" "High" "IsMasterProtein" "P49959" "Double-strand break repair protein MRE11 OS=Homo sapiens OX=9606 GN=MRE11 PE=1 SV=3" "0.000" "False" "121.292" "44" "26" "45" "26" "708" "80.5" "5.90" "164.29" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00149, Pf04152" "4361" "ENSG00000020922" "MRE11" "B3KTC7; hsa:4361; O43475; P49959" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; Breast cancer pathway; Joubert syndrome; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Cytosolic sensors of pathogen-associated DNA ; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks; IRF3-mediated induction of type I IFN" "31" "0" "1.027" "0.987" "1.008" "1.041" "1.009" "1.075" "1.021" "1.034" "1.017" "4048.3" "4157.0" "3996.3" "4081.3" "4213.0" "4082.8" "4352.5" "4132.8" "4185.1" "4116.5" "" "" "" "" "" "" "" "" "" "" "3639.9" "3363.7" "3614.8" "3983.9" "3476.6" "4082.8" "3259.1" "3650.4" "3744.8" "1469.5" "27" "27" "27" "27" "27" "27" "27" "27" "27" "27" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3366486650245995426" "False" "High" "IsMasterProtein" "P10515" "Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3" "0.000" "False" "121.157" "38" "19" "52" "19" "647" "69.0" "7.84" "203.47" "19" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "1737" "ENSG00000150768" "DLAT" "hsa:1737; P10515; Q16783; Q53EP3" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "8" "0" "0.984" "0.964" "0.977" "0.950" "0.927" "0.964" "1.009" "0.997" "0.741" "4524.0" "4452.6" "4362.3" "4422.0" "4299.6" "4195.1" "4360.2" "4563.3" "4511.5" "3350.3" "" "" "" "" "" "" "" "" "" "" "4067.6" "3602.8" "3945.8" "4316.5" "3548.1" "4195.1" "3264.8" "4030.6" "4036.8" "1196.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516954531369469772" "False" "High" "IsMasterProtein" "P60900" "Proteasome subunit alpha type-6 OS=Homo sapiens OX=9606 GN=PSMA6 PE=1 SV=1" "0.000" "False" "121.018" "56" "14" "77" "14" "246" "27.4" "6.76" "295.27" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00227, Pf10584" "5687" "ENSG00000100902" "PSMA6" "B2R7J9; B4DQR4; B4DXJ9; hsa:5687; P34062; P60900; Q6IB60" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.017" "0.999" "1.068" "1.000" "0.984" "0.958" "0.986" "1.037" "0.832" "7097.5" "7218.9" "7093.4" "7578.2" "7096.8" "6986.0" "6802.4" "6994.7" "7356.8" "5902.5" "" "" "" "" "" "" "" "" "" "" "6381.3" "5841.2" "6416.3" "7397.3" "5856.4" "6986.0" "5093.5" "6178.1" "6582.8" "2107.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6821815504623325969" "False" "High" "IsMasterProtein" "Q9UMX0" "Ubiquilin-1 OS=Homo sapiens OX=9606 GN=UBQLN1 PE=1 SV=2" "0.000" "False" "120.969" "26" "11" "58" "4" "589" "62.5" "5.11" "214.96" "11" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29979" "ENSG00000135018" "UBQLN1" "A0A024R284; hsa:29979; Q5T6J5; Q5T6J9; Q8IXS9; Q8N2Q3; Q9H0T8; Q9H3R4; Q9HAZ5; Q9UMX0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "1.036" "0.909" "1.003" "1.059" "0.960" "0.999" "0.999" "0.972" "0.870" "972.0" "1006.6" "883.7" "974.5" "1028.9" "933.4" "971.4" "970.9" "944.8" "845.3" "" "" "" "" "" "" "" "" "" "" "873.9" "814.5" "799.3" "951.2" "849.1" "933.4" "727.4" "857.5" "845.4" "301.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6575553270224251994" "False" "High" "IsMasterProtein" "P55010" "Eukaryotic translation initiation factor 5 OS=Homo sapiens OX=9606 GN=EIF5 PE=1 SV=2" "0.000" "False" "120.727" "50" "25" "57" "24" "431" "49.2" "5.58" "182.68" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01873, Pf02020" "1983" "ENSG00000100664" "EIF5" "hsa:1983; P55010; Q53XB3; Q9H5N2; Q9UG48" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "4" "1" "1.002" "0.971" "1.042" "0.991" "0.994" "1.000" "1.037" "0.954" "0.812" "5489.1" "5502.3" "5331.7" "5716.9" "5439.4" "5453.5" "5490.6" "5690.0" "5237.7" "4457.2" "" "" "" "" "" "" "" "" "" "" "4935.2" "4452.3" "4822.7" "5580.5" "4488.7" "5453.5" "4111.2" "5025.8" "4686.6" "1591.1" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6341568024441871550" "False" "High" "IsMasterProtein" "O75131" "Copine-3 OS=Homo sapiens OX=9606 GN=CPNE3 PE=1 SV=1" "0.000" "False" "120.455" "43" "21" "59" "21" "537" "60.1" "5.85" "213.08" "21" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00168, Pf07002" "8895" "ENSG00000085719" "CPNE3" "A8KA47; hsa:8895; O75131; Q8IYA1" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "1.013" "0.996" "0.999" "1.026" "0.976" "0.993" "1.001" "1.030" "0.859" "5793.3" "5870.5" "5771.3" "5790.0" "5941.9" "5654.3" "5752.4" "5799.6" "5964.7" "4979.2" "" "" "" "" "" "" "" "" "" "" "5208.8" "4750.2" "5220.3" "5651.8" "4903.4" "5654.3" "4307.3" "5122.6" "5337.2" "1777.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7742249596596208262" "False" "High" "IsMasterProtein" "Q7KZF4" "Staphylococcal nuclease domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SND1 PE=1 SV=1" "0.000" "False" "120.049" "32" "25" "35" "25" "910" "101.9" "7.17" "146.89" "25" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00565, Pf00567" "27044" "ENSG00000197157" "SND1" "hsa:27044; Q13122; Q7KZF4; Q96AG0" "VEGFA-VEGFR2 signaling" "Signaling by BRAF and RAF1 fusions" "2" "0" "1.013" "1.013" "0.995" "0.981" "1.011" "0.995" "0.770" "1.072" "10.251" "2559.0" "2591.2" "2591.6" "2546.9" "2511.2" "2587.0" "2546.0" "1971.2" "2744.1" "26232.2" "" "" "" "" "" "" "" "" "" "" "2300.8" "2096.7" "2344.2" "2486.1" "2072.3" "2587.0" "1906.3" "1741.1" "2455.4" "9364.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3497794903438612376" "False" "High" "IsMasterProtein" "Q92541" "RNA polymerase-associated protein RTF1 homolog OS=Homo sapiens OX=9606 GN=RTF1 PE=1 SV=4" "0.000" "False" "119.987" "37" "25" "45" "25" "710" "80.3" "8.15" "161.72" "25" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity" "Pf03126" "23168" "ENSG00000137815" "RTF1" "hsa:23168; Q92541; Q96BX6" "Endoderm differentiation" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins" "5" "0" "0.994" "1.029" "1.005" "1.027" "0.996" "0.994" "1.029" "1.024" "0.980" "4887.5" "4856.1" "5030.2" "4909.6" "5018.8" "4868.0" "4860.5" "5028.5" "5006.7" "4791.5" "" "" "" "" "" "" "" "" "" "" "4394.4" "3929.4" "4550.0" "4792.4" "4141.6" "4868.0" "3639.4" "4441.5" "4479.9" "1710.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176127761844367310" "False" "High" "IsMasterProtein" "Q9H2G2" "STE20-like serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=SLK PE=1 SV=1" "0.000" "False" "119.917" "25" "26" "39" "26" "1235" "142.6" "5.15" "151.86" "26" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "9748" "ENSG00000065613" "SLK" "D3DRA0; D3DRA1; hsa:9748; O00211; Q6P1Z4; Q86WU7; Q86WW1; Q92603; Q9H2G2; Q9NQL0; Q9NQL1" "TAR syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "4" "0" "0.983" "1.051" "0.971" "1.002" "1.022" "0.981" "1.021" "1.021" "0.940" "3702.8" "3641.7" "3892.1" "3596.1" "3710.1" "3782.4" "3631.9" "3780.6" "3779.4" "3479.5" "" "" "" "" "" "" "" "" "" "" "3329.2" "2946.7" "3520.5" "3510.3" "3061.6" "3782.4" "2719.5" "3339.2" "3381.8" "1242.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751284344252295029" "False" "High" "IsMasterProtein" "P06748" "Nucleophosmin OS=Homo sapiens OX=9606 GN=NPM1 PE=1 SV=2" "0.000" "False" "119.354" "43" "13" "93" "13" "294" "32.6" "4.78" "379.79" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "Pf03066, Pf16276" "4869" "ENSG00000181163" "NPM1" "A8K3N7; B5BU00; D3DQL6; hsa:4869; P06748; P08693; Q12826; Q13440; Q13441; Q14115; Q5EU94; Q5EU95; Q5EU96; Q5EU97; Q5EU98; Q5EU99; Q6V962; Q8WTW5; Q96AT6; Q96DC4; Q96EA5; Q9BYG9; Q9UDJ7" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; PKR-mediated signaling; Nuclear import of Rev protein; Deposition of new CENPA-containing nucleosomes at the centromere; SUMOylation of transcription cofactors; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1-host interactions" "10" "0" "0.883" "0.929" "0.802" "0.826" "1.179" "0.853" "0.859" "0.820" "0.702" "9532.0" "8418.3" "8856.1" "7645.0" "7875.5" "11242.2" "8126.3" "8192.5" "7814.2" "6688.7" "" "" "" "" "" "" "" "" "" "" "8570.2" "6811.8" "8010.6" "7462.6" "6499.0" "11242.2" "6084.8" "7236.2" "6992.1" "2387.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5135985212415519925" "False" "High" "IsMasterProtein" "P43686" "26S proteasome regulatory subunit 6B OS=Homo sapiens OX=9606 GN=PSMC4 PE=1 SV=2" "0.000" "False" "119.349" "45" "23" "50" "22" "418" "47.3" "5.21" "198.63" "23" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00004, Pf16450, Pf17862" "5704" "ENSG00000013275; ENSG00000281221" "PSMC4" "hsa:5704; P43686; Q96FV5; Q9UBM3; Q9UEX3" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "FCERI mediated NF-kB activation; Assembly of the pre-replicative complex; Regulation of RAS by GAPs; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Regulation of expression of SLITs and ROBOs; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "1.015" "1.024" "1.013" "0.984" "1.022" "0.985" "1.041" "1.042" "0.915" "4239.8" "4301.8" "4343.1" "4295.3" "4172.6" "4334.1" "4175.8" "4411.5" "4416.7" "3880.1" "" "" "" "" "" "" "" "" "" "" "3812.0" "3480.8" "3928.5" "4192.8" "3443.3" "4334.1" "3126.8" "3896.6" "3952.0" "1385.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "565785606400917725" "False" "High" "IsMasterProtein" "P26639" "Threonine--tRNA ligase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TARS1 PE=1 SV=3" "0.000" "False" "119.243" "45" "28" "45" "28" "723" "83.4" "6.67" "170.77" "28" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "6897" "ENSG00000113407" "TARS1" "A8K8I1; B4DEG8; hsa:6897; P26639; Q96FP5; Q9BWA6" "" "Cytosolic tRNA aminoacylation" "1" "0" "0.930" "0.975" "0.972" "0.912" "0.892" "0.957" "0.870" "0.896" "1.238" "5063.1" "4709.8" "4936.5" "4920.0" "4619.7" "4518.1" "4844.7" "4406.9" "4536.6" "6270.6" "" "" "" "" "" "" "" "" "" "" "4552.3" "3811.0" "4465.2" "4802.6" "3812.2" "4518.1" "3627.6" "3892.5" "4059.3" "2238.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-294736394566280624" "False" "High" "IsMasterProtein" "Q16204" "Coiled-coil domain-containing protein 6 OS=Homo sapiens OX=9606 GN=CCDC6 PE=1 SV=2" "0.000" "False" "119.185" "43" "19" "52" "19" "474" "53.3" "7.34" "191.75" "19" "cell organization and biogenesis" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf09755" "8030" "ENSG00000108091" "CCDC6" "hsa:8030; Q15250; Q16204; Q6GSG7" "Retinoblastoma gene in cancer; Mesodermal commitment pathway; 16p11.2 proximal deletion syndrome" "" "3" "0" "0.984" "0.965" "1.011" "1.031" "0.979" "1.010" "1.014" "0.999" "0.821" "4134.3" "4070.1" "3989.2" "4180.9" "4263.5" "4048.8" "4174.1" "4191.2" "4130.3" "3392.3" "" "" "" "" "" "" "" "" "" "" "3717.2" "3293.4" "3608.4" "4081.1" "3518.3" "4048.8" "3125.4" "3701.9" "3695.8" "1211.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1764632123327779223" "False" "High" "IsMasterProtein" "P46060" "Ran GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RANGAP1 PE=1 SV=1" "0.000" "False" "118.634" "39" "22" "44" "22" "587" "63.5" "4.68" "172.08" "22" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07834, Pf13516" "5905" "ENSG00000100401" "RANGAP1" "hsa:5905; P46060; Q96JJ2" "22q11.2 copy number variation syndrome; IL-18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of nuclear envelope proteins" "12" "0" "1.020" "0.981" "0.988" "1.140" "0.962" "1.050" "1.041" "0.953" "1.389" "3554.8" "3626.1" "3487.0" "3512.7" "4052.1" "3421.2" "3732.2" "3700.1" "3388.1" "4936.8" "" "" "" "" "" "" "" "" "" "" "3196.1" "2934.1" "3154.1" "3428.9" "3343.9" "3421.2" "2794.6" "3268.2" "3031.7" "1762.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-877235499680530927" "False" "High" "IsMasterProtein" "Q15366" "Poly(rC)-binding protein 2 OS=Homo sapiens OX=9606 GN=PCBP2 PE=1 SV=1" "0.000" "False" "118.533" "52" "14" "94" "7" "365" "38.6" "6.79" "326.62" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "5094" "ENSG00000197111" "PCBP2" "A8K7X6; B4DXP5; F8VYL7; G3V0E8; hsa:5094; I6L8F9; Q15366; Q32Q82; Q59HD4; Q68Y55; Q6IPF4; Q6PKG5" "mRNA processing; Ferroptosis; Modulators of TCR signaling and T cell activation" "mRNA Splicing - Major Pathway; Negative regulators of DDX58/IFIH1 signaling; Processing of Capped Intron-Containing Pre-mRNA; SARS-CoV-1 activates/modulates innate immune responses" "7" "1" "1.087" "0.998" "1.006" "1.164" "1.047" "1.113" "1.038" "1.015" "1.622" "2117.5" "2301.3" "2112.9" "2129.8" "2464.1" "2216.3" "2356.8" "2197.4" "2149.0" "3433.7" "" "" "" "" "" "" "" "" "" "" "1903.8" "1862.2" "1911.2" "2079.0" "2033.4" "2216.3" "1764.7" "1940.9" "1922.9" "1225.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6201262043542307507" "False" "High" "IsMasterProtein" "P34896" "Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=SHMT1 PE=1 SV=1" "0.000" "False" "118.375" "46" "18" "48" "17" "483" "53.0" "7.71" "193.04" "18" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00464" "6470" "ENSG00000176974; ENSG00000284320" "SHMT1" "B4DPM9; D3DXD0; hsa:6470; P34896; Q96HY0; Q9UMD1; Q9UMD2" "Glycine metabolism; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Male infertility; Neuroinflammation and glutamatergic signaling; Spina bifida; Metabolic Epileptic Disorders; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Metabolism of folate and pterines; Carnitine synthesis" "13" "0" "1.034" "1.070" "1.051" "1.088" "1.035" "1.042" "1.027" "1.094" "0.862" "2982.3" "3083.1" "3190.1" "3134.7" "3245.2" "3086.0" "3109.0" "3061.4" "3263.9" "2571.2" "" "" "" "" "" "" "" "" "" "" "2681.4" "2494.7" "2885.5" "3059.9" "2678.0" "3086.0" "2328.0" "2704.0" "2920.5" "917.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010508153477037857" "False" "High" "IsMasterProtein" "Q14103" "Heterogeneous nuclear ribonucleoprotein D0 OS=Homo sapiens OX=9606 GN=HNRNPD PE=1 SV=1" "0.000" "False" "118.125" "41" "17" "102" "14" "355" "38.4" "7.81" "363.58" "17" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08143" "3184" "ENSG00000138668" "HNRNPD" "A8K9J2; hsa:3184; P07029; Q01858; Q14100; Q14101; Q14102; Q14103; Q4W5A1; Q9UCE8; Q9UCE9" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "3" "0.972" "0.936" "1.028" "0.993" "1.019" "0.998" "1.078" "0.961" "0.762" "10334.7" "10050.4" "9669.0" "10626.8" "10265.2" "10529.2" "10311.2" "11136.8" "9930.4" "7878.5" "" "" "" "" "" "" "" "" "" "" "9291.9" "8132.4" "8745.9" "10373.2" "8471.0" "10529.2" "7720.8" "9836.7" "8885.6" "2812.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377635877244790923" "False" "High" "IsMasterProtein" "P36873" "Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CC PE=1 SV=1" "0.000" "False" "118.038" "62" "17" "50" "4" "323" "37.0" "6.54" "210.38" "17" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5501" "ENSG00000186298" "PPP1CC" "hsa:5501; P36873" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; Neuroinflammation and glutamatergic signaling" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Triglyceride catabolism; Circadian Clock; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "17" "0" "0.964" "0.994" "0.884" "1.041" "0.888" "1.029" "0.881" "0.914" "0.849" "555.5" "535.2" "552.3" "491.2" "578.1" "493.1" "571.6" "489.2" "507.7" "471.4" "" "" "" "" "" "" "" "" "" "" "499.4" "433.1" "499.6" "479.4" "477.1" "493.1" "428.0" "432.1" "454.3" "168.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5539470002617871814" "False" "High" "IsMasterProtein" "Q9P2R7" "Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLA2 PE=1 SV=3" "0.000" "False" "117.916" "46" "22" "49" "21" "463" "50.3" "7.42" "170.80" "22" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8803" "ENSG00000136143" "SUCLA2" "B2RDE7; hsa:8803; O95194; Q5T9Q4; Q5T9Q6; Q9NV21; Q9NVP7; Q9P2R7" "" "Citric acid cycle (TCA cycle)" "1" "1" "1.006" "0.998" "0.976" "1.012" "0.947" "1.023" "0.993" "1.015" "0.837" "5823.1" "5857.2" "5811.2" "5680.7" "5891.1" "5516.1" "5958.8" "5779.8" "5910.5" "4874.9" "" "" "" "" "" "" "" "" "" "" "5235.5" "4739.4" "5256.4" "5545.2" "4861.5" "5516.1" "4461.8" "5105.1" "5288.7" "1740.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017068245716453317" "False" "High" "IsMasterProtein" "O95782" "AP-2 complex subunit alpha-1 OS=Homo sapiens OX=9606 GN=AP2A1 PE=1 SV=3" "0.000" "False" "117.891" "32" "30" "47" "22" "977" "107.5" "7.03" "157.68" "30" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01602, Pf02296, Pf02883" "160" "ENSG00000196961" "AP2A1" "hsa:160; O95782; Q96CI7; Q96PP6; Q96PP7; Q9H070" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Trafficking of GluR2-containing AMPA receptors; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "21" "4" "1.011" "1.046" "0.994" "1.046" "1.015" "1.007" "0.991" "1.037" "1.039" "2809.0" "2839.2" "2938.8" "2792.1" "2937.5" "2851.5" "2828.0" "2784.2" "2912.3" "2918.6" "" "" "" "" "" "" "" "" "" "" "2525.6" "2297.3" "2658.2" "2725.5" "2424.1" "2851.5" "2117.5" "2459.2" "2605.9" "1041.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4686891910023409545" "False" "High" "IsMasterProtein" "P62140" "Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Homo sapiens OX=9606 GN=PPP1CB PE=1 SV=3" "0.000" "False" "117.865" "60" "16" "49" "5" "327" "37.2" "6.19" "203.10" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00149, Pf16891" "5500" "ENSG00000213639" "PPP1CB" "B2R5V4; D6W565; hsa:5500; P37140; P62140; Q5U087; Q6FG45" "Common pathways underlying drug addiction; Focal adhesion; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Airway smooth muscle cell contraction; Neuroinflammation and glutamatergic signaling; G13 signaling pathway" "Regulation of PLK1 Activity at G2/M Transition; Triglyceride catabolism; Circadian Clock; RHO GTPases activate CIT; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; Downregulation of TGF-beta receptor signaling; Maturation of hRSV A proteins" "19" "0" "0.996" "1.085" "1.005" "1.073" "1.013" "1.074" "0.985" "1.079" "0.936" "1413.6" "1407.7" "1533.7" "1420.1" "1516.8" "1431.9" "1517.5" "1392.4" "1526.0" "1322.7" "" "" "" "" "" "" "" "" "" "" "1271.0" "1139.1" "1387.3" "1386.2" "1251.7" "1431.9" "1136.3" "1229.9" "1365.4" "472.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490484038664760531" "False" "High" "IsMasterProtein" "Q13283" "Ras GTPase-activating protein-binding protein 1 OS=Homo sapiens OX=9606 GN=G3BP1 PE=1 SV=1" "0.000" "False" "117.610" "56" "17" "74" "17" "466" "52.1" "5.52" "318.61" "17" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "10146" "ENSG00000145907" "G3BP1" "hsa:10146; Q13283; Q5HYE9" "7q11.23 distal copy number variation; HDAC6 interactions in the central nervous system" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "3" "0" "1.019" "1.014" "1.044" "1.030" "1.056" "1.043" "1.045" "1.048" "0.854" "4007.8" "4082.3" "4065.7" "4184.3" "4129.9" "4233.1" "4178.6" "4186.7" "4198.8" "3421.8" "" "" "" "" "" "" "" "" "" "" "3603.4" "3303.3" "3677.6" "4084.4" "3408.1" "4233.1" "3128.9" "3698.0" "3757.1" "1221.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1042042739323188079" "False" "High" "IsMasterProtein" "Q9UQ35" "Serine/arginine repetitive matrix protein 2 OS=Homo sapiens OX=9606 GN=SRRM2 PE=1 SV=2" "0.000" "False" "117.583" "15" "31" "41" "31" "2752" "299.4" "12.06" "148.64" "31" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08312" "23524" "ENSG00000167978" "SRRM2" "A6NKB9; D3DU97; hsa:23524; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40; Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ35; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40" "" "mRNA Splicing - Major Pathway" "1" "0" "1.045" "0.981" "1.035" "1.005" "0.973" "1.053" "0.973" "0.892" "1.055" "3507.3" "3663.8" "3442.2" "3630.9" "3525.5" "3414.3" "3693.8" "3411.9" "3127.5" "3698.6" "" "" "" "" "" "" "" "" "" "" "3153.4" "2964.6" "3113.6" "3544.2" "2909.3" "3414.3" "2765.8" "3013.6" "2798.5" "1320.3" "26" "26" "26" "26" "26" "26" "26" "26" "26" "26" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312610725791659305" "False" "High" "IsMasterProtein" "P17812" "CTP synthase 1 OS=Homo sapiens OX=9606 GN=CTPS1 PE=1 SV=2" "0.000" "False" "117.271" "47" "26" "46" "23" "591" "66.6" "6.46" "180.55" "26" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "1503" "ENSG00000171793" "CTPS1" "B4DR64; D3DPW1; hsa:1503; P17812; Q5VW67; Q96GK6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "2" "0.964" "0.999" "1.015" "0.936" "0.951" "1.006" "0.928" "0.984" "0.825" "4761.8" "4588.8" "4755.1" "4834.8" "4457.3" "4527.8" "4789.5" "4419.1" "4684.9" "3929.8" "" "" "" "" "" "" "" "" "" "" "4281.4" "3713.1" "4301.1" "4719.4" "3678.3" "4527.8" "3586.2" "3903.3" "4192.0" "1402.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3607998631011874723" "False" "High" "IsMasterProtein" "Q9UBQ7" "Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens OX=9606 GN=GRHPR PE=1 SV=1" "0.000" "False" "117.241" "59" "17" "48" "17" "328" "35.6" "7.39" "202.50" "17" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00389, Pf02826" "9380" "ENSG00000137106" "GRHPR" "hsa:9380; Q5T945; Q9H3E9; Q9H636; Q9UBQ7; Q9UKX1" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.021" "0.996" "1.009" "1.024" "1.036" "1.034" "1.032" "1.026" "0.790" "5479.3" "5595.6" "5459.0" "5526.1" "5608.4" "5676.4" "5664.5" "5656.9" "5622.6" "4327.3" "" "" "" "" "" "" "" "" "" "" "4926.5" "4527.8" "4937.8" "5394.2" "4628.1" "5676.4" "4241.4" "4996.5" "5031.0" "1544.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4609810876488281286" "False" "High" "IsMasterProtein" "A0A2R8Y4L2" "Heterogeneous nuclear ribonucleoprotein A1-like 3 OS=Homo sapiens OX=9606 GN=HNRNPA1L3 PE=1 SV=2" "0.000" "False" "117.090" "48" "17" "150" "1" "320" "34.3" "9.00" "573.08" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11627" "" "ENSG00000224578" "HNRNPA1L3" "A0A2R8Y4L2" "" "" "0" "0" "1.004" "0.945" "1.055" "1.044" "0.911" "1.045" "1.074" "0.928" "0.847" "206.1" "207.0" "194.7" "217.5" "215.2" "187.7" "215.4" "221.4" "191.2" "174.5" "" "" "" "" "" "" "" "" "" "" "185.3" "167.5" "176.1" "212.3" "177.6" "187.7" "161.3" "195.6" "171.1" "62.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442629486260098393" "False" "High" "IsMasterProtein" "Q05397" "Focal adhesion kinase 1 OS=Homo sapiens OX=9606 GN=PTK2 PE=1 SV=2" "0.000" "False" "116.855" "30" "30" "45" "29" "1052" "119.2" "6.62" "158.10" "30" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "5747" "ENSG00000169398" "PTK2" "B4E2N6; F5H4S4; hsa:5747; J3QT16; Q05397; Q14291; Q8IYN9; Q9UD85" "Androgen receptor signaling pathway; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Corticotropin-releasing hormone signaling pathway; Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Apoptosis-related network due to altered Notch3 in ovarian cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Overview of nanoparticle effects; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Hippo-Merlin signaling dysregulation; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Small cell lung cancer; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Pleural mesothelioma; Regulation of actin cytoskeleton; 2q13 copy number variation syndrome; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 8q11.23 (RB1CC1) copy number variation; ErbB signaling pathway" "RAF/MAP kinase cascade; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; Signal regulatory protein family interactions; DCC mediated attractive signaling; VEGFA-VEGFR2 Pathway; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; MET activates PTK2 signaling; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Apoptotic cleavage of cellular proteins" "51" "0" "0.995" "1.023" "1.021" "1.022" "0.925" "0.991" "0.988" "0.985" "0.879" "2140.4" "2129.4" "2189.5" "2186.2" "2188.0" "1980.2" "2121.7" "2115.6" "2108.7" "1881.3" "" "" "" "" "" "" "" "" "" "" "1924.4" "1723.0" "1980.4" "2134.0" "1805.5" "1980.2" "1588.7" "1868.6" "1886.9" "671.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-355239685975103350" "False" "High" "IsMasterProtein" "O14578" "Citron Rho-interacting kinase OS=Homo sapiens OX=9606 GN=CIT PE=1 SV=2" "0.000" "False" "116.472" "18" "36" "41" "36" "2027" "231.3" "6.57" "135.86" "36" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433, Pf00780" "11113" "ENSG00000122966" "CIT" "hsa:11113; O14578; Q2M5E1; Q6XUH8; Q86UQ9; Q9UPZ7" "Pleural mesothelioma; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate CIT" "7" "0" "0.979" "1.011" "0.940" "0.923" "1.003" "0.914" "0.942" "0.989" "1.001" "2957.6" "2895.9" "2989.8" "2781.5" "2731.3" "2965.6" "2702.6" "2786.6" "2925.8" "2961.5" "" "" "" "" "" "" "" "" "" "" "2659.1" "2343.2" "2704.3" "2715.1" "2253.9" "2965.6" "2023.6" "2461.3" "2618.0" "1057.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2805084755290845876" "False" "High" "IsMasterProtein" "Q09161" "Nuclear cap-binding protein subunit 1 OS=Homo sapiens OX=9606 GN=NCBP1 PE=1 SV=1" "0.000" "False" "116.268" "29" "19" "43" "19" "790" "91.8" "6.43" "158.67" "19" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854, Pf09088, Pf09090" "4686" "ENSG00000136937" "NCBP1" "B2R718; hsa:4686; Q09161; Q59G76; Q5T1V0; Q5T7X2" "mRNA processing; 3q29 copy number variation syndrome" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs; Regulation of expression of SLITs and ROBOs; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "1.087" "1.057" "1.022" "1.103" "1.008" "1.089" "1.082" "1.076" "0.875" "3125.9" "3397.0" "3305.2" "3194.4" "3446.9" "3149.6" "3403.2" "3381.8" "3362.5" "2735.1" "" "" "" "" "" "" "" "" "" "" "2810.5" "2748.8" "2989.6" "3118.1" "2844.4" "3149.6" "2548.2" "2987.0" "3008.8" "976.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-566189082840404496" "False" "High" "IsMasterProtein" "Q8WVM7" "Cohesin subunit SA-1 OS=Homo sapiens OX=9606 GN=STAG1 PE=1 SV=3" "0.000" "False" "116.061" "24" "27" "45" "19" "1258" "144.3" "5.59" "155.27" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08514, Pf21581" "10274" "ENSG00000118007" "STAG1" "hsa:10274; O00539; Q6P275; Q8WVM7" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Meiotic synapsis; Estrogen-dependent gene expression; SUMOylation of DNA damage response and repair proteins; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "10" "0" "1.017" "1.009" "0.985" "1.046" "1.003" "1.057" "1.081" "1.035" "0.846" "987.3" "1004.4" "995.8" "972.4" "1032.5" "990.6" "1043.4" "1067.6" "1022.3" "835.5" "" "" "" "" "" "" "" "" "" "" "887.7" "812.8" "900.7" "949.2" "852.0" "990.6" "781.3" "942.9" "914.7" "298.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302543892740036521" "False" "High" "IsMasterProtein" "P82970" "High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens OX=9606 GN=HMGN5 PE=1 SV=1" "0.000" "False" "116.039" "51" "17" "56" "17" "282" "31.5" "4.55" "223.66" "17" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "79366" "ENSG00000198157" "HMGN5" "hsa:79366; P82970; Q5JSL1" "" "" "0" "0" "0.870" "0.874" "0.951" "0.855" "0.814" "0.898" "0.901" "0.829" "0.726" "8459.3" "7361.1" "7396.0" "8042.9" "7232.0" "6885.7" "7597.9" "7626.0" "7010.1" "6138.0" "" "" "" "" "" "" "" "" "" "" "7605.8" "5956.4" "6689.9" "7851.0" "5968.0" "6885.7" "5689.1" "6735.8" "6272.6" "2191.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348431233397446306" "False" "High" "IsMasterProtein" "P62495" "Eukaryotic peptide chain release factor subunit 1 OS=Homo sapiens OX=9606 GN=ETF1 PE=1 SV=3" "0.000" "False" "116.006" "38" "15" "56" "15" "437" "49.0" "5.71" "206.02" "15" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf03463, Pf03464, Pf03465" "2107" "ENSG00000120705" "ETF1" "B2R6B4; D3DQC1; hsa:2107; P46055; P62495; Q5M7Z7; Q96CG1" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "6" "0" "0.982" "0.976" "0.930" "1.014" "0.892" "0.992" "0.950" "0.949" "0.819" "5760.3" "5659.3" "5620.3" "5358.8" "5840.7" "5140.1" "5714.8" "5473.1" "5464.7" "4714.9" "" "" "" "" "" "" "" "" "" "" "5179.1" "4579.3" "5083.7" "5230.9" "4819.9" "5140.1" "4279.1" "4834.2" "4889.8" "1683.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6529775950404904251" "False" "High" "IsMasterProtein" "Q9UBC2" "Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens OX=9606 GN=EPS15L1 PE=1 SV=1" "0.000" "False" "115.970" "33" "23" "36" "23" "864" "94.2" "5.11" "144.17" "23" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "58513" "ENSG00000127527" "EPS15L1" "A2RRF3; A5PL29; B4DKA3; hsa:58513; Q9UBC2" "EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "4" "0" "0.965" "0.991" "1.006" "1.020" "0.943" "1.004" "0.998" "0.944" "1.900" "2890.5" "2790.3" "2864.4" "2908.4" "2947.2" "2727.0" "2902.0" "2883.9" "2728.2" "5492.1" "" "" "" "" "" "" "" "" "" "" "2598.8" "2257.8" "2590.9" "2839.0" "2432.1" "2727.0" "2173.0" "2547.3" "2441.2" "1960.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6737848688669361571" "False" "High" "IsMasterProtein" "Q9UNZ2" "NSFL1 cofactor p47 OS=Homo sapiens OX=9606 GN=NSFL1C PE=1 SV=2" "0.000" "False" "115.848" "57" "20" "42" "20" "370" "40.5" "5.10" "198.58" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00789, Pf08059, Pf14555" "55968" "ENSG00000088833" "NSFL1C" "A2A2L1; B2RD74; hsa:55968; Q5JXA4; Q5JXA5; Q7Z533; Q9H102; Q9NVL9; Q9UI06; Q9UNZ2" "Alstrom syndrome" "RHOH GTPase cycle" "2" "0" "0.971" "0.993" "1.024" "1.019" "1.000" "1.018" "1.014" "0.974" "0.895" "3664.0" "3557.9" "3639.9" "3753.2" "3734.5" "3664.4" "3731.3" "3714.6" "3569.7" "3279.0" "" "" "" "" "" "" "" "" "" "" "3294.3" "2878.9" "3292.4" "3663.6" "3081.8" "3664.4" "2793.9" "3280.9" "3194.1" "1170.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3281625266906913156" "False" "High" "IsMasterProtein" "Q7RTP6" "[F-actin]-monooxygenase MICAL3 OS=Homo sapiens OX=9606 GN=MICAL3 PE=1 SV=2" "0.000" "False" "115.670" "20" "36" "42" "36" "2002" "224.2" "5.55" "140.31" "36" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "57553" "ENSG00000243156" "MICAL3" "B2RXJ5; E9PEF0; O94909; Q5U4P4; Q6ICK4; Q7RTP6; Q96DF2; Q9P2I3" "" "" "0" "0" "1.038" "1.101" "0.973" "1.077" "1.091" "1.021" "1.077" "1.155" "1.065" "2448.3" "2541.9" "2695.6" "2382.3" "2637.9" "2671.0" "2499.6" "2636.4" "2827.2" "2606.9" "" "" "" "" "" "" "" "" "" "" "2201.3" "2056.8" "2438.3" "2325.5" "2176.8" "2671.0" "1871.6" "2328.7" "2529.7" "930.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1166927996766443346" "False" "High" "IsMasterProtein" "P28482" "Mitogen-activated protein kinase 1 OS=Homo sapiens OX=9606 GN=MAPK1 PE=1 SV=3" "0.000" "False" "115.659" "62" "19" "61" "13" "360" "41.4" "6.98" "202.07" "19" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "5594" "ENSG00000100030" "MAPK1" "A8CZ64; hsa:5594; P28482" "IL-5 signaling pathway; Osteopontin signaling; Physiological and pathological hypertrophy of the heart; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Heart development; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Aryl hydrocarbon receptor pathway; S1P receptor signal transduction; Ebstein-Barr virus LMP1 signaling; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; ERK pathway in Huntington's disease; Toll-like receptor signaling related to MyD88; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Bile acids synthesis and enterohepatic circulation ; LTF danger signal response pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; MAP3K1 role in promoting and blocking gonadal determination; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; RAS and bradykinin pathways in COVID-19; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; 2q11.2 copy number variation syndrome; 2q13 copy number variation syndrome; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; Female steroid hormones in cardiomyocyte energy metabolism; Cardiomyocyte signaling pathways converging on titin; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Vitamin A and carotenoid metabolism; Toll-like receptor signaling pathway" "Recycling pathway of L1; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Interferon gamma signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Estrogen-stimulated signaling through PRKCZ; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; Golgi Cisternae Pericentriolar Stack Reorganization; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; RHO GTPases Activate NADPH Oxidases; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants; phospho-PLA2 pathway; Signaling by MAPK mutants" "208" "6" "1.021" "0.996" "0.971" "1.023" "0.939" "0.962" "0.986" "0.996" "0.806" "5809.4" "5931.8" "5786.1" "5638.3" "5940.2" "5456.9" "5591.5" "5727.5" "5786.3" "4684.0" "" "" "" "" "" "" "" "" "" "" "5223.3" "4799.8" "5233.7" "5503.7" "4901.9" "5456.9" "4186.7" "5058.9" "5177.6" "1672.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431694603937659134" "False" "High" "IsMasterProtein" "P15531" "Nucleoside diphosphate kinase A OS=Homo sapiens OX=9606 GN=NME1 PE=1 SV=1" "0.000" "False" "115.659" "86" "12" "109" "7" "152" "17.1" "6.19" "414.38" "12" "DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "translation activity;kinase activity;other molecular function" "Pf00334" "4830" "ENSG00000239672" "NME1" "hsa:4830; P15531; Q6FGK3; Q86XQ2; Q9UDJ6" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME; Ribavirin ADME" "4" "0" "1.016" "0.989" "1.029" "1.059" "0.937" "1.029" "0.996" "1.025" "0.780" "5345.5" "5432.3" "5289.0" "5499.2" "5662.2" "5006.2" "5502.7" "5324.8" "5477.1" "4169.4" "" "" "" "" "" "" "" "" "" "" "4806.1" "4395.6" "4784.1" "5368.0" "4672.5" "5006.2" "4120.3" "4703.2" "4900.9" "1488.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2637590011477773491" "False" "High" "IsMasterProtein" "P46459" "Vesicle-fusing ATPase OS=Homo sapiens OX=9606 GN=NSF PE=1 SV=3" "0.000" "False" "115.556" "40" "30" "45" "30" "744" "82.5" "6.95" "158.40" "30" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00004, Pf02359, Pf02933, Pf17862" "4905" "ENSG00000073969; ENSG00000276262; ENSG00000278174" "NSF" "A8K2D9; B4DFA2; P46459; Q8N6D7; Q9UKZ2" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Vasopressin-regulated water reabsorption" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network; Trafficking of GluR2-containing AMPA receptors" "9" "0" "0.999" "0.914" "0.982" "0.992" "0.934" "1.052" "0.973" "0.971" "0.888" "3545.7" "3541.6" "3242.5" "3483.6" "3516.5" "3312.0" "3728.9" "3449.6" "3443.7" "3149.2" "" "" "" "" "" "" "" "" "" "" "3187.9" "2865.7" "2932.9" "3400.5" "2901.8" "3312.0" "2792.1" "3046.9" "3081.4" "1124.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471595991882746273" "False" "High" "IsMasterProtein" "P35612" "Beta-adducin OS=Homo sapiens OX=9606 GN=ADD2 PE=1 SV=3" "0.000" "False" "115.482" "34" "21" "36" "21" "726" "80.8" "5.92" "138.05" "21" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "119" "ENSG00000075340" "ADD2" "A8K4P2; B4DM17; D6W5G7; D6W5G8; hsa:119; P35612; Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; Q7Z689; Q7Z690; Q7Z691" "" "Miscellaneous transport and binding events" "1" "0" "1.014" "0.959" "0.963" "1.022" "0.959" "0.990" "0.973" "0.962" "1.002" "2551.9" "2586.3" "2448.3" "2457.0" "2609.2" "2446.9" "2527.0" "2483.7" "2455.3" "2558.0" "" "" "" "" "" "" "" "" "" "" "2294.4" "2092.8" "2214.6" "2398.4" "2153.1" "2446.9" "1892.1" "2193.7" "2197.0" "913.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3397920079809031089" "False" "High" "IsMasterProtein" "Q7Z5R6" "Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens OX=9606 GN=APBB1IP PE=1 SV=1" "0.000" "False" "115.157" "37" "22" "52" "22" "666" "73.1" "5.59" "194.86" "22" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf00169, Pf00788" "54518" "ENSG00000077420" "APBB1IP" "hsa:54518; Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7" "TYROBP causal network in microglia" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "11" "0" "1.040" "0.967" "1.033" "1.039" "0.969" "1.011" "1.053" "0.999" "0.877" "4914.5" "5112.6" "4752.6" "5076.7" "5108.4" "4763.9" "4966.5" "5174.6" "4908.4" "4308.1" "" "" "" "" "" "" "" "" "" "" "4418.7" "4136.9" "4298.9" "4955.5" "4215.5" "4763.9" "3718.8" "4570.6" "4392.0" "1537.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256235105362563928" "False" "High" "IsMasterProtein" "P62937" "Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens OX=9606 GN=PPIA PE=1 SV=2" "0.000" "False" "115.134" "72" "16" "327" "15" "165" "18.0" "7.81" "880.96" "16" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00160" "5478" "ENSG00000196262" "PPIA" "A8K220; hsa:5478; P05092; P62937; Q3KQW3; Q567Q0; Q6IBU5; Q96IX3; Q9BRU4; Q9BTY9; Q9UC61" "Prolactin signaling pathway" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Budding and maturation of HIV virion; Platelet degranulation ; Basigin interactions; SARS-CoV-1 activates/modulates innate immune responses; Integration of provirus; APOBEC3G mediated resistance to HIV-1 infection; Calcineurin activates NFAT; Binding and entry of HIV virion; Assembly Of The HIV Virion; Uncoating of the HIV Virion; Minus-strand DNA synthesis; Plus-strand DNA synthesis" "16" "1" "1.073" "1.009" "1.189" "1.004" "1.079" "1.023" "1.048" "1.001" "0.888" "25033.2" "26854.9" "25262.8" "29765.1" "25132.1" "26999.7" "25606.4" "26238.4" "25053.6" "22226.3" "" "" "" "" "" "" "" "" "" "" "22507.3" "21730.0" "22851.0" "29054.9" "20739.5" "26999.7" "19173.4" "23175.5" "22417.8" "7934.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5875685193594640149" "False" "High" "IsMasterProtein" "Q7Z3U7" "Protein MON2 homolog OS=Homo sapiens OX=9606 GN=MON2 PE=1 SV=3" "0.000" "False" "114.973" "20" "32" "35" "32" "1717" "190.2" "6.06" "121.52" "32" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf09324, Pf12783, Pf16206, Pf16213" "23041" "ENSG00000061987" "MON2" "A5D8U7; A7E2Y0; B9EGP5; F8VWA6; F8W1Z6; hsa:23041; Q7Z3U7; Q86TA2; Q8N3I5; Q8NAI0; Q8NHE2; Q9UPW1" "" "" "0" "0" "1.015" "1.086" "0.973" "0.987" "0.988" "0.960" "0.986" "0.987" "1.092" "2956.7" "3000.5" "3209.7" "2877.1" "2918.2" "2921.2" "2839.0" "2916.0" "2919.0" "3230.2" "" "" "" "" "" "" "" "" "" "" "2658.4" "2427.9" "2903.3" "2808.5" "2408.2" "2921.2" "2125.8" "2575.6" "2611.9" "1153.1" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-560084501499272066" "False" "High" "IsMasterProtein" "Q8IY18" "Structural maintenance of chromosomes protein 5 OS=Homo sapiens OX=9606 GN=SMC5 PE=1 SV=2" "0.000" "False" "114.716" "28" "28" "36" "28" "1101" "128.7" "8.38" "126.25" "28" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02463" "23137" "ENSG00000198887" "SMC5" "A6NM81; hsa:23137; O60335; Q05D92; Q5VZ60; Q8IY18; Q96SB9" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.959" "0.930" "0.909" "0.956" "0.952" "0.912" "0.930" "0.904" "0.903" "2814.4" "2699.7" "2616.5" "2557.3" "2691.5" "2678.5" "2567.1" "2617.8" "2543.2" "2540.3" "" "" "" "" "" "" "" "" "" "" "2530.4" "2184.5" "2366.7" "2496.3" "2221.1" "2678.5" "1922.1" "2312.2" "2275.7" "906.8" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5279606303405418158" "False" "High" "IsMasterProtein" "Q9H2K8" "Serine/threonine-protein kinase TAO3 OS=Homo sapiens OX=9606 GN=TAOK3 PE=1 SV=2" "0.000" "False" "114.703" "29" "26" "48" "22" "898" "105.3" "7.30" "154.90" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "51347" "ENSG00000135090" "TAOK3" "hsa:51347; Q658N1; Q8IUM4; Q9H2K8; Q9HC79; Q9NZM9; Q9UHG7" "MAPK signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle" "4" "3" "1.051" "0.973" "1.028" "1.071" "0.976" "0.990" "1.054" "1.056" "0.834" "3094.8" "3252.5" "3011.0" "3182.8" "3315.1" "3020.8" "3064.6" "3263.0" "3269.2" "2579.7" "" "" "" "" "" "" "" "" "" "" "2782.6" "2631.8" "2723.5" "3106.9" "2735.7" "3020.8" "2294.7" "2882.1" "2925.2" "920.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832303337719112949" "False" "High" "IsMasterProtein" "Q15154" "Pericentriolar material 1 protein OS=Homo sapiens OX=9606 GN=PCM1 PE=1 SV=6" "0.000" "False" "114.249" "19" "31" "38" "30" "2024" "228.4" "5.02" "130.23" "31" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15717" "5108" "ENSG00000078674" "PCM1" "A6NNN6; B4DYD5; E7ETA6; E7EV56; hsa:5108; Q15154; Q58F13; Q6P1K7; Q8NB85; Q9BWC1; Q9H4A2" "Prader-Willi and Angelman syndrome; Joubert syndrome" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "1.003" "1.055" "0.927" "1.065" "1.010" "1.033" "0.974" "1.022" "0.815" "2042.2" "2047.6" "2153.7" "1893.4" "2174.0" "2063.1" "2109.2" "1988.1" "2086.4" "1664.8" "" "" "" "" "" "" "" "" "" "" "1836.2" "1656.8" "1948.1" "1848.3" "1794.0" "2063.1" "1579.3" "1756.0" "1866.9" "594.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6605193621902288169" "False" "High" "IsMasterProtein" "Cont_P35908" "Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2" "0.000" "True" "114.203" "46" "26" "37" "18" "639" "65.4" "8.00" "148.57" "26" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3849" "ENSG00000172867" "KRT2" "hsa:3849; P35908; Q4VAQ2" "" "Formation of the cornified envelope" "2" "3" "0.465" "0.678" "1.117" "0.499" "2.284" "0.907" "1.034" "0.694" "3.338" "2590.3" "1205.2" "1756.6" "2893.2" "1292.8" "5915.8" "2348.9" "2677.2" "1797.8" "8645.6" "" "" "" "" "" "" "" "" "" "" "2328.9" "975.2" "1588.9" "2824.1" "1066.8" "5915.8" "1758.8" "2364.7" "1608.7" "3086.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6804108956499343623" "False" "High" "IsMasterProtein" "Q96G03" "Phosphopentomutase OS=Homo sapiens OX=9606 GN=PGM2 PE=1 SV=4" "0.000" "False" "114.195" "42" "25" "51" "25" "612" "68.2" "6.73" "175.55" "25" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "55276" "ENSG00000169299" "PGM2" "B4E0G8; hsa:55276; Q53FP5; Q5QTR0; Q96G03; Q9H0P9; Q9NV22" "Clear cell renal cell carcinoma pathways; Glucuronidation" "Neutrophil degranulation; Pentose phosphate pathway" "4" "0" "1.004" "1.009" "0.952" "1.015" "0.902" "0.950" "0.944" "0.995" "0.774" "6404.2" "6426.7" "6459.3" "6099.0" "6499.5" "5774.3" "6084.7" "6043.0" "6369.8" "4954.2" "" "" "" "" "" "" "" "" "" "" "5758.0" "5200.3" "5842.6" "5953.5" "5363.5" "5774.3" "4556.1" "5337.5" "5699.7" "1768.5" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2636434062481616227" "False" "High" "IsMasterProtein" "P42858" "Huntingtin OS=Homo sapiens OX=9606 GN=HTT PE=1 SV=2" "0.000" "False" "114.149" "11" "32" "41" "32" "3142" "347.4" "6.20" "137.19" "32" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf20925, Pf20926, Pf20927" "3064" "ENSG00000197386" "HTT" "hsa:3064; P42858; Q9UQB7" "Mesodermal commitment pathway; Mesodermal commitment pathway; ERK pathway in Huntington's disease; Rett syndrome; 15q25 copy number variation; HDAC6 interactions in the central nervous system" "Regulation of MECP2 expression and activity" "7" "0" "1.016" "0.989" "0.912" "1.037" "1.066" "0.992" "0.985" "0.990" "1.071" "2396.8" "2436.3" "2371.6" "2185.1" "2485.7" "2553.9" "2377.8" "2361.1" "2371.8" "2567.8" "" "" "" "" "" "" "" "" "" "" "2155.0" "1971.4" "2145.2" "2133.0" "2051.2" "2553.9" "1780.4" "2085.5" "2122.3" "916.6" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4038126070754837566" "False" "High" "IsMasterProtein" "Cont_Q3SYV4" "Adenylyl cyclase-associated protein 1 OS=Bos taurus OX=9913 GN=CAP1 PE=2 SV=3" "0.000" "True" "114.117" "29" "15" "86" "1" "472" "51.2" "7.52" "298.36" "15" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf01213, Pf08603" "109556455; 504519" "" "CAP1" "A0A6P5BIK1; biu:109556455; bta:504519; Q3SYV4" "" "" "0" "0" "0.963" "0.943" "1.085" "1.007" "1.032" "1.068" "1.074" "1.051" "0.964" "466.5" "449.1" "439.9" "506.2" "469.6" "481.4" "498.1" "500.9" "490.2" "449.7" "" "" "" "" "" "" "" "" "" "" "419.4" "363.4" "397.9" "494.1" "387.5" "481.4" "373.0" "442.4" "438.7" "160.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3259999118554299265" "False" "High" "IsMasterProtein" "Q16181" "Septin-7 OS=Homo sapiens OX=9606 GN=SEPTIN7 PE=1 SV=2" "0.000" "False" "114.088" "46" "22" "71" "20" "437" "50.6" "8.63" "228.36" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00735" "989" "ENSG00000122545" "SEPTIN7" "hsa:989; Q16181; Q52M76; Q6NX50" "" "MAPK6/MAPK4 signaling" "1" "1" "1.049" "0.999" "1.067" "1.007" "1.062" "1.015" "1.068" "1.017" "0.858" "5186.5" "5440.3" "5179.3" "5535.4" "5220.3" "5509.4" "5263.4" "5538.7" "5273.7" "4450.7" "" "" "" "" "" "" "" "" "" "" "4663.2" "4402.1" "4684.9" "5403.3" "4307.9" "5509.4" "3941.1" "4892.1" "4718.8" "1588.8" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8545908257350266971" "False" "High" "IsMasterProtein" "O15144" "Actin-related protein 2/3 complex subunit 2 OS=Homo sapiens OX=9606 GN=ARPC2 PE=1 SV=1" "0.000" "False" "113.931" "60" "20" "64" "20" "300" "34.3" "7.36" "220.96" "20" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04045" "10109" "ENSG00000163466" "ARPC2" "hsa:10109; O15144; Q92801; Q9P1D4" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.028" "1.029" "1.006" "1.014" "0.968" "0.995" "1.002" "1.007" "0.773" "7792.6" "8013.8" "8020.9" "7842.7" "7902.3" "7540.4" "7756.5" "7805.2" "7847.2" "6024.8" "" "" "" "" "" "" "" "" "" "" "7006.3" "6484.5" "7255.2" "7655.6" "6521.1" "7540.4" "5807.8" "6894.1" "7021.6" "2150.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534228375388649933" "False" "High" "IsMasterProtein" "P52948" "Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens OX=9606 GN=NUP98 PE=1 SV=4" "0.000" "False" "113.784" "20" "32" "44" "32" "1817" "197.5" "6.40" "146.74" "32" "cell organization and biogenesis;protein metabolism;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04096, Pf12110, Pf21240" "4928" "ENSG00000110713" "NUP98" "hsa:4928; P52948; Q8IUT2; Q8WYB0; Q96E54; Q9H3Q4; Q9NT02; Q9UF57; Q9UHX0; Q9Y6J4; Q9Y6J5" "SARS-CoV-2 innate immunity evasion and cell-specific immune response" "" "1" "0" "1.065" "1.044" "1.006" "1.049" "1.046" "1.075" "1.027" "1.040" "1.058" "3285.9" "3498.2" "3429.5" "3307.3" "3446.4" "3437.7" "3531.8" "3376.1" "3418.2" "3475.4" "" "" "" "" "" "" "" "" "" "" "2954.4" "2830.6" "3102.1" "3228.3" "2844.1" "3437.7" "2644.5" "2982.0" "3058.6" "1240.6" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4212925493234983848" "False" "High" "IsMasterProtein" "Q14289" "Protein-tyrosine kinase 2-beta OS=Homo sapiens OX=9606 GN=PTK2B PE=1 SV=2" "0.000" "False" "113.498" "33" "31" "43" "30" "1009" "115.8" "6.25" "149.11" "31" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "transporter activity;kinase activity;other molecular function" "Pf00373, Pf03623, Pf07714, Pf18038, Pf21477" "2185" "ENSG00000120899" "PTK2B" "D3DST0; hsa:2185; Q13475; Q14289; Q14290; Q16709; Q6PID4" "IL-7 signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Hepatocyte growth factor receptor signaling; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; EGF/EGFR signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-2 signaling pathway; CCL18 signaling pathway; NPHP1 deletion syndrome; 8q11.23 (RB1CC1) copy number variation; HDAC6 interactions in the central nervous system; T-cell receptor signaling pathway" "RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Signal regulatory protein family interactions; Interleukin-2 signaling" "21" "1" "0.950" "0.960" "0.954" "0.941" "0.856" "1.037" "0.817" "0.834" "2.972" "3486.0" "3311.7" "3347.7" "3325.9" "3282.1" "2985.4" "3615.4" "2849.1" "2908.5" "10361.8" "" "" "" "" "" "" "" "" "" "" "3134.3" "2679.7" "3028.1" "3246.6" "2708.4" "2985.4" "2707.1" "2516.6" "2602.5" "3698.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3787459776374465912" "False" "High" "IsMasterProtein" "Q9Y5L0" "Transportin-3 OS=Homo sapiens OX=9606 GN=TNPO3 PE=1 SV=3" "0.000" "False" "113.482" "35" "26" "44" "26" "923" "104.1" "5.57" "160.66" "26" "transport" "other membranes;nucleus;other cell component" "other molecular function" "Pf08389" "23534" "ENSG00000064419" "TNPO3" "A4D1K9; C9IZM0; hsa:23534; Q6NUM1; Q96G71; Q96GU9; Q9Y3R2; Q9Y5L0" "" "" "0" "0" "1.021" "1.014" "0.948" "1.045" "0.952" "1.014" "0.994" "0.983" "1.001" "2666.4" "2722.6" "2704.9" "2528.4" "2786.6" "2538.5" "2703.0" "2649.3" "2620.1" "2669.0" "" "" "" "" "" "" "" "" "" "" "2397.3" "2203.1" "2446.6" "2468.1" "2299.6" "2538.5" "2023.9" "2340.0" "2344.5" "952.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8199308046116639924" "False" "High" "IsMasterProtein" "Q29RF7" "Sister chromatid cohesion protein PDS5 homolog A OS=Homo sapiens OX=9606 GN=PDS5A PE=1 SV=1" "0.000" "False" "113.297" "28" "30" "33" "26" "1337" "150.7" "7.91" "132.51" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf20168" "23244" "ENSG00000121892" "PDS5A" "hsa:23244; Q29RF7; Q2TTR5; Q68DF7; Q8N7J4; Q8NG14; Q9Y4D4" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "0.956" "0.905" "0.969" "0.947" "0.902" "0.987" "0.866" "0.830" "3.525" "1747.8" "1670.2" "1581.7" "1694.2" "1654.5" "1577.1" "1724.8" "1513.1" "1451.4" "6161.0" "" "" "" "" "" "" "" "" "" "" "1571.4" "1351.5" "1430.7" "1653.8" "1365.3" "1577.1" "1291.5" "1336.4" "1298.7" "2199.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4287058177622287432" "False" "High" "IsMasterProtein" "O95757" "Heat shock 70 kDa protein 4L OS=Homo sapiens OX=9606 GN=HSPA4L PE=1 SV=3" "0.000" "False" "113.067" "36" "25" "45" "21" "839" "94.5" "5.88" "165.56" "25" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00012" "22824" "ENSG00000164070" "HSPA4L" "A2ICT2; hsa:22824; O95757; Q4W5M5; Q8IWA2" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.017" "1.060" "1.011" "1.024" "1.017" "1.013" "1.012" "1.051" "0.954" "2221.2" "2258.6" "2353.4" "2244.6" "2274.9" "2259.2" "2250.9" "2246.9" "2334.3" "2118.3" "" "" "" "" "" "" "" "" "" "" "1997.1" "1827.6" "2128.7" "2191.0" "1877.3" "2259.2" "1685.4" "1984.6" "2088.7" "756.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2015286030572761336" "False" "High" "IsMasterProtein" "P24752" "Acetyl-CoA acetyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAT1 PE=1 SV=1" "0.000" "False" "113.008" "47" "19" "69" "19" "427" "45.2" "8.85" "245.67" "19" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00108, Pf02803" "38" "ENSG00000075239" "ACAT1" "B2R6H1; G3XAB4; hsa:38; P24752; Q96FG8" "Fatty acid beta-oxidation; Tryptophan metabolism; SARS-CoV-2 and COVID-19 pathway" "Mitochondrial protein degradation; Branched-chain amino acid catabolism; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "7" "0" "1.029" "1.017" "1.014" "1.005" "0.989" "0.995" "1.024" "1.024" "0.800" "6829.1" "7025.2" "6944.3" "6921.9" "6866.3" "6757.0" "6797.6" "6991.6" "6991.6" "5463.7" "" "" "" "" "" "" "" "" "" "" "6140.0" "5684.6" "6281.3" "6756.7" "5666.2" "6757.0" "5089.9" "6175.5" "6256.0" "1950.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3042753504910158627" "False" "High" "IsMasterProtein" "P13804" "Electron transfer flavoprotein subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=ETFA PE=1 SV=1" "0.000" "False" "112.816" "61" "15" "52" "15" "333" "35.1" "8.38" "218.70" "15" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00766, Pf01012" "2108" "ENSG00000140374" "ETFA" "B4DT43; hsa:2108; P13804; Q53XN3" "" "Respiratory electron transport" "1" "0" "0.984" "0.949" "0.997" "0.987" "0.924" "0.992" "1.000" "0.933" "0.767" "5676.7" "5587.3" "5385.2" "5661.0" "5603.5" "5245.4" "5632.4" "5674.6" "5297.6" "4355.0" "" "" "" "" "" "" "" "" "" "" "5103.9" "4521.0" "4871.1" "5525.9" "4624.1" "5245.4" "4217.4" "5012.2" "4740.3" "1554.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6930052097087835026" "False" "High" "IsMasterProtein" "Q15003" "Condensin complex subunit 2 OS=Homo sapiens OX=9606 GN=NCAPH PE=1 SV=3" "0.000" "False" "112.628" "37" "24" "40" "24" "741" "82.5" "5.06" "159.41" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05786" "23397" "ENSG00000121152" "NCAPH" "B4E189; hsa:23397; Q15003; Q8TB87" "2q11.2 copy number variation syndrome" "Condensation of Prometaphase Chromosomes" "2" "0" "1.047" "1.004" "1.012" "1.058" "0.982" "1.036" "1.036" "1.034" "1.346" "3182.4" "3331.2" "3196.5" "3221.7" "3366.8" "3126.1" "3295.8" "3297.5" "3289.2" "4284.2" "" "" "" "" "" "" "" "" "" "" "2861.3" "2695.5" "2891.3" "3144.8" "2778.4" "3126.1" "2467.8" "2912.6" "2943.2" "1529.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6066576864868279087" "False" "High" "IsMasterProtein" "Q9Y263" "Phospholipase A-2-activating protein OS=Homo sapiens OX=9606 GN=PLAA PE=1 SV=2" "0.000" "False" "112.615" "37" "24" "39" "24" "795" "87.1" "6.37" "134.49" "24" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf08324, Pf09070" "9373" "ENSG00000137055" "PLAA" "hsa:9373; Q53EU5; Q5VY33; Q9NUL8; Q9NVE9; Q9UF53; Q9Y263; Q9Y5L1" "" "" "0" "0" "1.059" "1.043" "0.980" "1.095" "1.039" "1.078" "1.004" "1.074" "1.481" "2300.9" "2436.1" "2400.7" "2255.1" "2519.3" "2390.0" "2480.7" "2310.7" "2470.7" "3407.8" "" "" "" "" "" "" "" "" "" "" "2068.8" "1971.2" "2171.5" "2201.3" "2079.0" "2390.0" "1857.5" "2041.0" "2210.8" "1216.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037912225033679960" "False" "High" "IsMasterProtein" "P47756" "F-actin-capping protein subunit beta OS=Homo sapiens OX=9606 GN=CAPZB PE=1 SV=5" "0.000" "False" "112.587" "64" "18" "73" "18" "272" "30.6" "6.00" "249.11" "18" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01115" "832" "ENSG00000077549" "CAPZB" "hsa:832; P47756; Q32Q68; Q5U0L4; Q8TB49; Q9NUC4" "VEGFA-VEGFR2 signaling" "MHC class II antigen presentation; Sensory processing of sound by inner hair cells of the cochlea; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; RHOD GTPase cycle; RHOF GTPase cycle; Factors involved in megakaryocyte development and platelet production" "9" "0" "1.025" "1.045" "1.034" "1.039" "1.040" "1.040" "1.038" "1.053" "0.899" "5695.1" "5838.9" "5951.2" "5886.0" "5915.6" "5920.5" "5922.4" "5909.0" "5994.4" "5119.6" "" "" "" "" "" "" "" "" "" "" "5120.5" "4724.6" "5383.1" "5745.6" "4881.7" "5920.5" "4434.6" "5219.2" "5363.8" "1827.5" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4886602285452216196" "False" "High" "IsMasterProtein" "Q92696" "Geranylgeranyl transferase type-2 subunit alpha OS=Homo sapiens OX=9606 GN=RABGGTA PE=1 SV=2" "0.000" "False" "112.528" "51" "23" "32" "23" "567" "65.0" "5.67" "131.07" "23" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00560, Pf01239, Pf07711" "5875" "ENSG00000100949; ENSG00000285193" "RABGGTA" "A8K5N2; D3DS69; hsa:5875; Q92696" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "0.994" "0.986" "0.964" "0.980" "0.959" "0.971" "0.983" "0.991" "0.777" "2769.9" "2754.4" "2730.6" "2671.0" "2715.8" "2655.2" "2688.6" "2724.2" "2743.7" "2153.1" "" "" "" "" "" "" "" "" "" "" "2490.4" "2228.8" "2469.9" "2607.2" "2241.1" "2655.2" "2013.2" "2406.2" "2455.0" "768.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857660237806613264" "False" "High" "IsMasterProtein" "Q9NXV6" "CDKN2A-interacting protein OS=Homo sapiens OX=9606 GN=CDKN2AIP PE=1 SV=3" "0.000" "False" "112.465" "49" "22" "36" "22" "580" "61.1" "9.01" "144.59" "22" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf11952" "55602" "ENSG00000168564" "CDKN2AIP" "hsa:55602; Q8TBM5; Q9NXV6; Q9NYH0" "" "" "0" "0" "1.024" "1.054" "1.050" "1.038" "1.049" "1.056" "1.033" "1.071" "0.949" "3167.1" "3244.4" "3339.6" "3324.3" "3286.2" "3322.6" "3343.8" "3272.4" "3392.2" "3007.0" "" "" "" "" "" "" "" "" "" "" "2847.5" "2625.2" "3020.7" "3245.0" "2711.8" "3322.6" "2503.8" "2890.4" "3035.3" "1073.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5761790178817742854" "False" "High" "IsMasterProtein" "Q96P70" "Importin-9 OS=Homo sapiens OX=9606 GN=IPO9 PE=1 SV=3" "0.000" "False" "112.358" "31" "28" "45" "28" "1041" "115.9" "4.81" "154.37" "28" "transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03810" "55705" "ENSG00000198700" "IPO9" "B1ASV5; hsa:55705; Q8N1Y1; Q8N3I2; Q8NCG9; Q96P70; Q96SU6; Q9NW01; Q9P0A8; Q9ULM8" "" "" "0" "0" "1.081" "1.068" "0.954" "1.090" "0.990" "1.042" "1.022" "1.056" "0.920" "3024.5" "3269.4" "3231.1" "2885.9" "3295.8" "2993.0" "3151.7" "3091.8" "3192.7" "2781.4" "" "" "" "" "" "" "" "" "" "" "2719.3" "2645.5" "2922.7" "2817.1" "2719.8" "2993.0" "2359.9" "2730.9" "2856.8" "992.9" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359022296663299879" "False" "High" "IsMasterProtein" "Q14258" "E3 ubiquitin/ISG15 ligase TRIM25 OS=Homo sapiens OX=9606 GN=TRIM25 PE=1 SV=2" "0.000" "False" "112.236" "44" "24" "39" "24" "630" "70.9" "8.09" "162.74" "24" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00622, Pf13445, Pf13765" "7706" "ENSG00000121060" "TRIM25" "hsa:7706; Q14258" "Novel intracellular components of RIG-I-like receptor pathway; Cytosolic DNA-sensing pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; 1p36 copy number variation syndrome" "SARS-CoV-1 activates/modulates innate immune responses; Interferon gamma signaling; RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses" "19" "0" "1.032" "1.065" "1.025" "1.063" "1.070" "1.068" "1.086" "1.072" "1.060" "3113.6" "3213.4" "3315.3" "3190.7" "3308.3" "3330.8" "3324.6" "3381.5" "3339.1" "3299.5" "" "" "" "" "" "" "" "" "" "" "2799.4" "2600.2" "2998.8" "3114.5" "2730.1" "3330.8" "2489.4" "2986.7" "2987.8" "1177.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6780722004559034825" "False" "High" "IsMasterProtein" "P35520" "Cystathionine beta-synthase OS=Homo sapiens OX=9606 GN=CBS PE=1 SV=2" "0.000" "False" "112.058" "43" "17" "34" "17" "551" "60.5" "6.65" "144.10" "17" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00291, Pf00571" "102724560; 875" "ENSG00000160200" "CBS" "B2R993; D3DSK4; hsa:102724560; hsa:875; P35520; Q99425; Q9BWC5" "Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Vitamin D receptor pathway; Amino acid metabolism; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis; Ciliary landscape" "Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "13" "0" "1.011" "1.011" "0.984" "1.030" "1.010" "1.026" "1.022" "1.028" "0.765" "1856.7" "1876.4" "1877.5" "1827.4" "1911.7" "1875.7" "1904.2" "1896.7" "1908.6" "1420.7" "" "" "" "" "" "" "" "" "" "" "1669.3" "1518.3" "1698.2" "1783.8" "1577.6" "1875.7" "1425.8" "1675.3" "1707.8" "507.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4807008432777767819" "False" "High" "IsMasterProtein" "Q9NTZ6" "RNA-binding protein 12 OS=Homo sapiens OX=9606 GN=RBM12 PE=1 SV=1" "0.000" "False" "111.852" "23" "20" "49" "20" "932" "97.3" "8.63" "162.60" "20" "other biological processes" "nucleus;other cell component" "" "Pf00076" "10137" "ENSG00000244462" "RBM12" "B3KRU2; E1P5R6; hsa:10137; O94865; Q8N3B1; Q9H196; Q9NTZ6" "" "" "0" "0" "1.026" "1.028" "0.986" "1.037" "1.010" "1.045" "1.000" "0.988" "1.128" "3406.4" "3493.9" "3502.5" "3359.9" "3531.2" "3441.4" "3560.2" "3405.1" "3365.8" "3842.1" "" "" "" "" "" "" "" "" "" "" "3062.7" "2827.2" "3168.1" "3279.7" "2914.0" "3441.4" "2665.8" "3007.6" "3011.7" "1371.5" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6844923263172623256" "False" "High" "IsMasterProtein" "Q9BXP5" "Serrate RNA effector molecule homolog OS=Homo sapiens OX=9606 GN=SRRT PE=1 SV=1" "0.000" "False" "111.665" "32" "25" "39" "25" "876" "100.6" "5.96" "150.88" "25" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04959, Pf12066" "51593" "ENSG00000087087" "SRRT" "A4D2E5; A4D2E6; A6NK22; B4DJL4; B4DZA6; hsa:51593; O95808; Q32MI4; Q6NT74; Q8TDQ5; Q9BWP6; Q9BXP4; Q9BXP5; Q9Y4S4" "" "mRNA Splicing - Major Pathway; RNA polymerase II transcribes snRNA genes" "2" "0" "0.939" "0.975" "0.974" "0.897" "0.956" "1.031" "0.885" "0.826" "1.917" "4765.0" "4474.8" "4644.3" "4641.6" "4274.6" "4556.6" "4913.9" "4215.3" "3933.9" "9136.6" "" "" "" "" "" "" "" "" "" "" "4284.2" "3620.9" "4200.9" "4530.8" "3527.5" "4556.6" "3679.4" "3723.2" "3520.1" "3261.5" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5250221047475229599" "False" "High" "IsMasterProtein" "Q7LBC6" "Lysine-specific demethylase 3B OS=Homo sapiens OX=9606 GN=KDM3B PE=1 SV=2" "0.000" "False" "111.602" "18" "28" "39" "26" "1761" "191.5" "7.18" "137.34" "28" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "51780" "ENSG00000120733" "KDM3B" "A6H8X7; hsa:51780; Q7LBC6; Q9BVH6; Q9BW93; Q9BZ52; Q9NYF4; Q9UPS0" "Thermogenesis" "HDMs demethylate histones" "2" "1" "1.059" "1.056" "1.030" "1.101" "1.099" "1.056" "1.047" "1.030" "1.293" "3444.0" "3647.0" "3636.1" "3547.4" "3791.4" "3784.9" "3636.8" "3607.3" "3547.5" "4453.1" "" "" "" "" "" "" "" "" "" "" "3096.5" "2951.0" "3289.0" "3462.8" "3128.7" "3784.9" "2723.2" "3186.2" "3174.3" "1589.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7902692244369353681" "False" "High" "IsMasterProtein" "Q9Y6G9" "Cytoplasmic dynein 1 light intermediate chain 1 OS=Homo sapiens OX=9606 GN=DYNC1LI1 PE=1 SV=3" "0.000" "False" "111.584" "51" "23" "38" "22" "523" "56.5" "6.42" "136.08" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "51143" "ENSG00000144635" "DYNC1LI1" "A2RRG7; hsa:51143; Q53HC8; Q53HK7; Q9Y6G9" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; RHO GTPases Activate Formins; HCMV Early Events; Separation of Sister Chromatids; Neutrophil degranulation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "16" "1" "0.933" "0.921" "0.953" "0.927" "0.896" "0.898" "0.936" "0.948" "1.044" "2844.7" "2653.1" "2621.2" "2712.1" "2637.6" "2548.3" "2553.2" "2662.1" "2695.6" "2970.3" "" "" "" "" "" "" "" "" "" "" "2557.6" "2146.8" "2371.0" "2647.3" "2176.6" "2548.3" "1911.7" "2351.3" "2412.0" "1060.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4137666002023082164" "False" "High" "IsMasterProtein" "Cont_P00761" "Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1" "0.000" "True" "111.578" "56" "10" "189" "9" "231" "24.4" "7.18" "678.46" "10" "protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "" "" "" "" "" "" "0" "1" "0.900" "0.917" "0.985" "0.813" "0.772" "0.963" "0.812" "0.778" "0.828" "15104.8" "13599.4" "13849.7" "14880.1" "12280.0" "11656.1" "14551.5" "12268.7" "11748.8" "12500.1" "" "" "" "" "" "" "" "" "" "" "13580.7" "11004.1" "12527.5" "14525.1" "10133.7" "11656.1" "10895.8" "10836.5" "10512.8" "4462.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830366311257218609" "False" "High" "IsMasterProtein" "P48147" "Prolyl endopeptidase OS=Homo sapiens OX=9606 GN=PREP PE=1 SV=2" "0.000" "False" "111.541" "48" "28" "41" "28" "710" "80.6" "5.86" "145.64" "28" "protein metabolism" "cytosol;nucleus;other cell component" "other molecular function" "Pf00326, Pf02897" "5550" "ENSG00000085377" "PREP" "hsa:5550; P48147; Q8N6D4" "" "" "0" "0" "0.981" "1.005" "0.960" "0.975" "0.941" "0.977" "0.919" "0.969" "1.708" "2409.7" "2363.2" "2422.3" "2313.8" "2348.7" "2267.9" "2355.1" "2214.5" "2334.3" "4115.2" "" "" "" "" "" "" "" "" "" "" "2166.5" "1912.2" "2191.0" "2258.6" "1938.2" "2267.9" "1763.5" "1956.0" "2088.7" "1469.0" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7719784497129908869" "False" "High" "IsMasterProtein" "O60566" "Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Homo sapiens OX=9606 GN=BUB1B PE=1 SV=3" "0.000" "False" "111.394" "28" "27" "35" "27" "1050" "119.5" "5.27" "135.77" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf08311" "701" "ENSG00000156970" "BUB1B" "B2R6U0; B4DL09; B4DLG3; hsa:701; O60501; O60566; O60627; O60758; O75389; Q59HH6; Q8WV50; Q96KM4" "Regulation of sister chromatid separation at the metaphase-anaphase transition; 10q22q23 copy number variation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "1.057" "1.228" "0.964" "1.071" "1.245" "1.052" "1.011" "1.259" "1.464" "2690.6" "2845.0" "3302.8" "2594.3" "2882.0" "3349.2" "2831.8" "2720.0" "3387.7" "3938.4" "" "" "" "" "" "" "" "" "" "" "2419.1" "2302.1" "2987.5" "2532.4" "2378.3" "3349.2" "2120.4" "2402.5" "3031.3" "1405.9" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3232925650926593770" "False" "High" "IsMasterProtein" "Q9C0C2" "182 kDa tankyrase-1-binding protein OS=Homo sapiens OX=9606 GN=TNKS1BP1 PE=1 SV=4" "0.000" "False" "111.391" "21" "28" "34" "28" "1729" "181.7" "4.86" "130.42" "28" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15327" "85456" "ENSG00000149115" "TNKS1BP1" "A7E2F8; hsa:85456; Q6PJ35; Q6ZV74; Q9C0C2" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "0.945" "1.061" "0.938" "1.026" "1.040" "0.993" "0.977" "1.092" "0.846" "1948.5" "1841.0" "2067.3" "1826.8" "1998.5" "2026.1" "1935.5" "1902.8" "2127.0" "1647.5" "" "" "" "" "" "" "" "" "" "" "1751.9" "1489.6" "1869.9" "1783.3" "1649.2" "2026.1" "1449.3" "1680.7" "1903.2" "588.1" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9100750251972445181" "False" "High" "IsMasterProtein" "Q14C86" "GTPase-activating protein and VPS9 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GAPVD1 PE=1 SV=2" "0.000" "False" "111.380" "21" "27" "36" "27" "1478" "164.9" "5.22" "139.11" "27" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf02204, Pf18151" "26130" "ENSG00000165219" "GAPVD1" "A8MYK3; B0QZ62; B0QZ63; B0QZ64; hsa:26130; Q14C76; Q14C86; Q2Q1W1; Q8ND92; Q8WU86; Q96CZ4; Q9NXQ1; Q9P207; Q9Y4N0" "" "RAB GEFs exchange GTP for GDP on RABs; Clathrin-mediated endocytosis" "2" "0" "1.023" "1.068" "1.004" "1.032" "1.047" "1.074" "1.021" "1.098" "1.678" "3325.2" "3400.1" "3552.0" "3339.0" "3430.2" "3482.0" "3571.7" "3395.8" "3651.4" "5578.6" "" "" "" "" "" "" "" "" "" "" "2989.7" "2751.3" "3212.9" "3259.3" "2830.7" "3482.0" "2674.4" "2999.4" "3267.3" "1991.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3295496481374294049" "False" "High" "IsMasterProtein" "Q9UHD9" "Ubiquilin-2 OS=Homo sapiens OX=9606 GN=UBQLN2 PE=1 SV=2" "0.000" "False" "111.374" "28" "12" "50" "6" "624" "65.7" "5.22" "197.39" "12" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "29978" "ENSG00000188021" "UBQLN2" "hsa:29978; O94798; Q5D027; Q9H3W6; Q9HAZ4; Q9UHD9" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "6" "0.968" "0.966" "0.975" "0.996" "1.004" "0.984" "1.000" "1.020" "0.904" "2804.1" "2714.4" "2710.1" "2732.7" "2792.2" "2815.1" "2760.6" "2803.9" "2861.4" "2534.3" "" "" "" "" "" "" "" "" "" "" "2521.2" "2196.4" "2451.3" "2667.5" "2304.2" "2815.1" "2067.1" "2476.6" "2560.4" "904.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741204735065001472" "False" "High" "IsMasterProtein" "Q8WXF1" "Paraspeckle component 1 OS=Homo sapiens OX=9606 GN=PSPC1 PE=1 SV=1" "0.000" "False" "111.339" "36" "20" "53" "19" "523" "58.7" "6.67" "186.53" "20" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08075" "55269" "ENSG00000121390" "PSPC1" "hsa:55269; Q5JTQ3; Q8NCZ9; Q8WXE8; Q8WXF1; Q9NV36" "" "" "0" "0" "0.990" "0.950" "1.042" "0.933" "1.022" "0.977" "1.023" "0.900" "1.188" "4527.1" "4482.1" "4298.7" "4719.3" "4225.9" "4628.1" "4425.1" "4629.7" "4074.8" "5376.7" "" "" "" "" "" "" "" "" "" "" "4070.3" "3626.8" "3888.3" "4606.7" "3487.3" "4628.1" "3313.4" "4089.3" "3646.1" "1919.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4858909322532710110" "False" "High" "IsMasterProtein" "Q16881" "Thioredoxin reductase 1, cytoplasmic OS=Homo sapiens OX=9606 GN=TXNRD1 PE=1 SV=3" "0.000" "False" "111.144" "44" "21" "45" "20" "649" "70.9" "7.39" "161.68" "21" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462, Pf02852, Pf07992" "7296" "ENSG00000198431" "TXNRD1" "B7Z1F4; B7Z3Y8; B7Z904; E9PMY9; F5H780; hsa:7296; Q16881; Q6FI31; Q6VB40; Q6VB41; Q6VB42; Q6VBP2; Q6VBP3; Q6VBP4; Q6VBP5; Q6VBP9; Q6VBQ0; Q6YNQ1; Q76P53; Q7LA96; Q8WVC8; Q99475; Q9UES8; Q9UH79" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Nuclear receptors meta-pathway; NRF2 pathway; Oxidative stress response; Ferroptosis" "Detoxification of Reactive Oxygen Species; PPARA activates gene expression; TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; Metabolism of ingested H2SeO4 and H2SeO3 into H2Se; Uptake and function of diphtheria toxin; Metabolism of ingested MeSeO2H into MeSeH" "16" "1" "1.033" "1.023" "0.982" "1.040" "1.004" "1.009" "0.994" "1.019" "0.798" "3495.7" "3612.0" "3575.9" "3432.8" "3634.2" "3508.9" "3525.7" "3474.5" "3563.5" "2789.3" "" "" "" "" "" "" "" "" "" "" "3142.9" "2922.7" "3234.5" "3350.9" "2999.0" "3508.9" "2640.0" "3068.9" "3188.6" "995.7" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002487047349753336" "False" "High" "IsMasterProtein" "P22392" "Nucleoside diphosphate kinase B OS=Homo sapiens OX=9606 GN=NME2 PE=1 SV=1" "0.000" "False" "111.143" "84" "14" "104" "4" "152" "17.3" "8.41" "354.23" "14" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00334" "4831; 654364" "ENSG00000243678" "NME2" "A8MWA3; hsa:4831; hsa:654364; P22392; Q1WM23; Q6LCT6" "Pyrimidine metabolism" "Neutrophil degranulation; Azathioprine ADME; Interconversion of nucleotide di- and triphosphates; Ribavirin ADME" "5" "12" "1.017" "0.979" "1.132" "0.990" "1.032" "0.968" "1.029" "0.984" "0.802" "10772.6" "10959.8" "10546.3" "12195.6" "10668.8" "11121.1" "10424.2" "11082.1" "10600.8" "8644.6" "" "" "" "" "" "" "" "" "" "" "9685.6" "8868.3" "9539.4" "11904.6" "8804.0" "11121.1" "7805.4" "9788.5" "9485.5" "3085.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1734790582977372175" "False" "High" "IsMasterProtein" "P54136" "Arginine--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=RARS1 PE=1 SV=2" "0.000" "False" "111.113" "37" "22" "40" "22" "660" "75.3" "6.68" "156.45" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00750, Pf03485, Pf05746" "5917" "ENSG00000113643" "RARS1" "B2RBS9; hsa:5917; P54136; Q53GY4; Q9BWA1" "Amino acid metabolism" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.984" "1.019" "1.014" "0.911" "0.951" "1.000" "0.909" "1.044" "3.314" "2783.7" "2739.2" "2835.7" "2822.1" "2535.1" "2648.6" "2784.9" "2530.8" "2905.9" "9224.5" "" "" "" "" "" "" "" "" "" "" "2502.8" "2216.4" "2565.0" "2754.8" "2092.1" "2648.6" "2085.3" "2235.4" "2600.2" "3292.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-165801227635855458" "False" "High" "IsMasterProtein" "Q00839" "Heterogeneous nuclear ribonucleoprotein U OS=Homo sapiens OX=9606 GN=HNRNPU PE=1 SV=6" "0.000" "False" "110.976" "30" "23" "53" "23" "825" "90.5" "6.00" "191.63" "23" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00622, Pf02037, Pf13671" "3192" "ENSG00000153187" "HNRNPU" "hsa:3192; O75507; Q00839; Q8N174; Q96HY9; Q9BQ09" "mRNA processing; lncRNA in canonical Wnt signaling and colorectal cancer" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "1.152" "1.155" "1.054" "1.084" "1.189" "1.052" "1.146" "1.160" "1.762" "3716.4" "4280.9" "4293.4" "3917.6" "4028.2" "4420.0" "3909.3" "4259.3" "4311.1" "6548.0" "" "" "" "" "" "" "" "" "" "" "3341.4" "3464.0" "3883.5" "3824.1" "3324.2" "4420.0" "2927.2" "3762.1" "3857.6" "2337.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5999519850232784779" "False" "High" "IsMasterProtein" "Q9Y3L3" "SH3 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3BP1 PE=1 SV=3" "0.000" "False" "110.707" "38" "21" "44" "21" "701" "75.7" "6.77" "161.33" "21" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "23616" "ENSG00000100092" "SH3BP1" "hsa:23616; Q5R3N0; Q6IBZ2; Q6ZVL9; Q96HQ5; Q9NSQ9; Q9Y3L3" "" "RAC1 GTPase cycle" "1" "0" "0.965" "1.031" "1.016" "1.010" "1.014" "1.019" "1.001" "1.050" "0.875" "4096.5" "3952.1" "4223.8" "4160.2" "4138.4" "4153.2" "4173.1" "4098.7" "4301.4" "3583.6" "" "" "" "" "" "" "" "" "" "" "3683.2" "3197.9" "3820.6" "4060.9" "3415.1" "4153.2" "3124.7" "3620.2" "3848.8" "1279.2" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5868182849043771837" "False" "High" "IsMasterProtein" "Q15084" "Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1" "0.000" "False" "110.611" "50" "16" "48" "16" "440" "48.1" "5.08" "218.69" "16" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00085" "10130" "ENSG00000143870" "PDIA6" "B3KY95; B5MCQ5; B7Z254; B7Z4M8; F8WA83; hsa:10130; Q15084; Q53RC7; Q6ZSH5; Q99778" "Photodynamic therapy-induced unfolded protein response; VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "1.034" "1.026" "1.003" "1.096" "1.045" "1.049" "1.064" "1.112" "0.815" "4460.6" "4610.9" "4576.3" "4472.4" "4888.3" "4663.3" "4679.3" "4748.1" "4958.8" "3636.1" "" "" "" "" "" "" "" "" "" "" "4010.5" "3731.0" "4139.4" "4365.7" "4033.9" "4663.3" "3503.7" "4193.8" "4437.1" "1298.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201863361074030149" "False" "High" "IsMasterProtein" "O95071" "E3 ubiquitin-protein ligase UBR5 OS=Homo sapiens OX=9606 GN=UBR5 PE=1 SV=2" "0.000" "False" "110.209" "12" "32" "34" "32" "2799" "309.2" "5.85" "114.52" "32" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00632, Pf00658, Pf11547" "51366" "ENSG00000104517" "UBR5" "B2RP24; hsa:51366; J3KMW7; O94970; O95071; Q9NPL3" "Mesodermal commitment pathway" "" "1" "0" "1.040" "0.990" "0.937" "1.007" "0.973" "0.982" "0.998" "1.019" "1.563" "1819.6" "1891.8" "1801.5" "1705.4" "1832.5" "1771.0" "1787.6" "1816.0" "1854.0" "2844.2" "" "" "" "" "" "" "" "" "" "" "1636.0" "1530.8" "1629.5" "1664.7" "1512.3" "1771.0" "1338.5" "1604.0" "1658.9" "1015.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8165870367093882655" "False" "High" "IsMasterProtein" "Q86TI2" "Dipeptidyl peptidase 9 OS=Homo sapiens OX=9606 GN=DPP9 PE=1 SV=3" "0.000" "False" "110.013" "25" "18" "42" "17" "863" "98.2" "6.46" "150.48" "18" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "91039" "ENSG00000142002" "DPP9" "hsa:91039; O75273; O75868; Q1ZZB8; Q6AI37; Q6UAL0; Q6ZMT2; Q6ZNJ5; Q86TI2; Q8N2J7; Q8N3F5; Q8WXD8; Q96NT8; Q9BVR3" "Lung fibrosis" "" "1" "1" "1.003" "0.946" "0.983" "0.984" "0.918" "1.008" "0.890" "0.926" "1.042" "2995.6" "3004.3" "2833.8" "2944.0" "2947.8" "2748.5" "3021.0" "2666.4" "2772.4" "3120.5" "" "" "" "" "" "" "" "" "" "" "2693.3" "2431.0" "2563.3" "2873.8" "2432.6" "2748.5" "2262.0" "2355.1" "2480.7" "1113.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1882334441137329574" "False" "High" "IsMasterProtein" "Q9BUJ2" "Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Homo sapiens OX=9606 GN=HNRNPUL1 PE=1 SV=2" "0.000" "False" "109.895" "34" "21" "34" "21" "856" "95.7" "6.92" "142.95" "21" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00622, Pf02037, Pf13671" "11100" "ENSG00000105323" "HNRNPUL1" "B3KMW7; hsa:11100; O76022; Q6ZSZ0; Q7L8P4; Q8N6Z4; Q96G37; Q9BUJ2; Q9HAL3; Q9UG75" "" "" "0" "0" "0.966" "1.032" "1.112" "1.121" "1.016" "1.039" "1.045" "1.032" "1.382" "3155.8" "3048.3" "3256.2" "3507.9" "3537.4" "3207.4" "3278.1" "3297.3" "3258.2" "4362.7" "" "" "" "" "" "" "" "" "" "" "2837.4" "2466.6" "2945.4" "3424.2" "2919.1" "3207.4" "2454.6" "2912.4" "2915.4" "1557.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1274747088330592999" "False" "High" "IsMasterProtein" "O94973" "AP-2 complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=AP2A2 PE=1 SV=2" "0.000" "False" "109.880" "25" "23" "38" "15" "939" "103.9" "6.96" "135.71" "23" "transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01602, Pf02296, Pf02883" "161" "ENSG00000183020" "AP2A2" "hsa:161; O75403; O94973; Q53ET1; Q96SI8" "Synaptic vesicle pathway; GABA receptor signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Cell lineage map for neuronal differentiation" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Neutrophil degranulation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.026" "1.034" "1.004" "1.026" "0.992" "0.993" "1.007" "1.036" "0.960" "1931.6" "1982.4" "1997.2" "1940.3" "1981.2" "1915.5" "1918.5" "1945.4" "2001.6" "1854.1" "" "" "" "" "" "" "" "" "" "" "1736.7" "1604.1" "1806.6" "1894.0" "1635.0" "1915.5" "1436.5" "1718.3" "1791.0" "661.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5104868076877432039" "False" "High" "IsMasterProtein" "Q9HC38" "Glyoxalase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GLOD4 PE=1 SV=1" "0.000" "False" "109.843" "65" "18" "42" "18" "313" "34.8" "5.60" "165.86" "18" "" "mitochondrion" "" "Pf21207, Pf21701" "51031" "ENSG00000167699" "GLOD4" "D3DTG9; D3DTH1; hsa:51031; Q96B89; Q9H3J8; Q9HC37; Q9HC38; Q9NVN1" "" "" "0" "0" "0.964" "0.990" "0.979" "0.957" "0.957" "0.996" "0.958" "0.928" "0.947" "4801.8" "4630.0" "4754.6" "4701.8" "4597.0" "4596.5" "4783.1" "4599.3" "4457.9" "4545.6" "" "" "" "" "" "" "" "" "" "" "4317.3" "3746.4" "4300.7" "4589.6" "3793.5" "4596.5" "3581.5" "4062.4" "3988.9" "1622.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740854368523393254" "False" "High" "IsMasterProtein" "Q9NR30" "Nucleolar RNA helicase 2 OS=Homo sapiens OX=9606 GN=DDX21 PE=1 SV=5" "0.000" "False" "109.698" "36" "24" "37" "24" "783" "87.3" "9.28" "135.39" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08152" "9188" "ENSG00000165732" "DDX21" "B2RDL0; hsa:9188; Q13436; Q5VX41; Q68D35; Q9NR30" "10q11.21q11.23 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.931" "0.910" "0.871" "0.910" "1.097" "0.918" "0.766" "0.768" "0.961" "2405.7" "2238.9" "2190.1" "2094.7" "2188.8" "2638.3" "2208.1" "1841.8" "1846.7" "2311.0" "" "" "" "" "" "" "" "" "" "" "2163.0" "1811.7" "1981.0" "2044.8" "1806.2" "2638.3" "1653.4" "1626.8" "1652.4" "824.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3509050462547548554" "False" "High" "IsMasterProtein" "Q04917" "14-3-3 protein eta OS=Homo sapiens OX=9606 GN=YWHAH PE=1 SV=4" "0.000" "False" "109.678" "68" "16" "148" "11" "246" "28.2" "4.84" "437.40" "16" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00244" "7533" "ENSG00000128245" "YWHAH" "hsa:7533; Q04917" "Cell cycle; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; Sudden infant death syndrome (SIDS) susceptibility pathways" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria" "11" "0" "0.976" "0.977" "0.946" "0.990" "0.982" "0.942" "0.985" "0.992" "0.807" "4957.3" "4840.0" "4844.8" "4688.2" "4906.7" "4865.8" "4668.4" "4880.6" "4918.8" "4002.2" "" "" "" "" "" "" "" "" "" "" "4457.1" "3916.4" "4382.3" "4576.4" "4049.1" "4865.8" "3495.6" "4310.8" "4401.3" "1428.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1633285367868477603" "False" "High" "IsMasterProtein" "P35241" "Radixin OS=Homo sapiens OX=9606 GN=RDX PE=1 SV=1" "0.000" "False" "109.594" "25" "19" "74" "3" "583" "68.5" "6.37" "260.39" "19" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "5962" "ENSG00000137710" "RDX" "A7YIJ8; A7YIK0; A7YIK3; B7Z9U6; F5H1A7; hsa:5962; P35241; Q86Y61" "Regulation of actin cytoskeleton" "Recycling pathway of L1; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "4" "0" "1.365" "1.148" "0.997" "1.307" "1.258" "0.983" "1.047" "1.091" "0.753" "57.3" "78.2" "65.8" "57.1" "74.9" "72.1" "56.4" "60.0" "62.6" "43.2" "" "" "" "" "" "" "" "" "" "" "51.5" "63.3" "59.5" "55.8" "61.8" "72.1" "42.2" "53.0" "56.0" "15.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5794288011295636240" "False" "High" "IsMasterProtein" "O60502" "Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2" "0.000" "False" "109.578" "34" "27" "47" "27" "916" "102.8" "4.91" "176.47" "27" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07555" "10724" "ENSG00000198408" "OGA" "B7WPB9; D3DR79; E9PGF9; hsa:10724; O60502; O75166; Q86WV0; Q8IV98; Q9BVA5; Q9HAR0" "" "" "0" "0" "1.025" "0.978" "1.011" "1.014" "0.956" "0.966" "0.969" "0.986" "0.928" "4245.1" "4349.8" "4153.1" "4291.1" "4305.4" "4058.5" "4099.0" "4112.9" "4183.6" "3937.8" "" "" "" "" "" "" "" "" "" "" "3816.7" "3519.7" "3756.6" "4188.7" "3552.9" "4058.5" "3069.2" "3632.8" "3743.4" "1405.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7512060777885112035" "False" "High" "IsMasterProtein" "P63244" "Small ribosomal subunit protein RACK1 OS=Homo sapiens OX=9606 GN=RACK1 PE=1 SV=3" "0.000" "False" "109.554" "72" "19" "50" "19" "317" "35.1" "7.69" "223.79" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;cytosol;mitochondrion;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;translation activity;other molecular function" "Pf00400" "10399" "ENSG00000204628" "RACK1" "B3KTJ0; D3DWS0; hsa:10399; P25388; P63244; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47" "Androgen receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Angiotensin II receptor type 1 pathway; TROP2 regulatory signaling; Interferon type I signaling pathways" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-mediated ceramide production" "10" "0" "1.064" "1.014" "0.998" "1.074" "1.090" "1.053" "1.018" "1.057" "1.088" "4029.5" "4288.9" "4086.2" "4020.5" "4326.8" "4391.1" "4243.4" "4102.1" "4258.7" "4382.1" "" "" "" "" "" "" "" "" "" "" "3622.9" "3470.4" "3696.1" "3924.6" "3570.6" "4391.1" "3177.4" "3623.2" "3810.6" "1564.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7179197342339518209" "False" "High" "IsMasterProtein" "P52907" "F-actin-capping protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=CAPZA1 PE=1 SV=3" "0.000" "False" "109.391" "64" "11" "54" "9" "286" "32.9" "5.69" "239.11" "11" "cell organization and biogenesis" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "829" "ENSG00000116489" "CAPZA1" "hsa:829; P52907; Q53FQ6; Q6FHD5" "" "Sensory processing of sound by inner hair cells of the cochlea; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "8" "0" "1.000" "0.986" "0.991" "1.003" "0.964" "0.987" "0.987" "1.026" "0.899" "2714.3" "2715.2" "2675.3" "2689.8" "2721.5" "2616.7" "2679.4" "2679.4" "2784.5" "2439.6" "" "" "" "" "" "" "" "" "" "" "2440.4" "2197.0" "2419.9" "2625.7" "2245.8" "2616.7" "2006.2" "2366.6" "2491.6" "870.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3405025144750981774" "False" "High" "IsMasterProtein" "P52732" "Kinesin-like protein KIF11 OS=Homo sapiens OX=9606 GN=KIF11 PE=1 SV=2" "0.000" "False" "109.232" "29" "30" "35" "30" "1056" "119.1" "5.64" "137.52" "30" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf13931" "3832" "ENSG00000138160" "KIF11" "A0AV49; B2RMV3; hsa:3832; P52732; Q15716; Q5VWX0" "" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "3" "0" "1.042" "1.325" "0.964" "1.028" "1.293" "1.055" "0.976" "1.367" "2.683" "3334.4" "3473.2" "4419.2" "3214.5" "3427.4" "4310.0" "3516.7" "3255.9" "4559.1" "8945.4" "" "" "" "" "" "" "" "" "" "" "2997.9" "2810.4" "3997.4" "3137.8" "2828.3" "4310.0" "2633.2" "2875.8" "4079.5" "3193.3" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7075703887839209806" "False" "High" "IsMasterProtein" "Q14CX7" "N-alpha-acetyltransferase 25, NatB auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA25 PE=1 SV=1" "0.000" "False" "109.190" "32" "28" "42" "28" "972" "112.2" "6.64" "139.41" "28" "" "cytosol;ER/Golgi;other cell component" "" "Pf09797" "80018" "ENSG00000111300" "NAA25" "A0JLU7; hsa:80018; Q14CX7; Q6MZH1; Q7Z4N6; Q9H911" "" "" "0" "0" "1.036" "0.967" "0.997" "1.018" "0.994" "1.020" "1.001" "1.023" "0.916" "3289.5" "3408.2" "3180.3" "3279.3" "3348.8" "3270.1" "3354.7" "3292.8" "3366.0" "3013.1" "" "" "" "" "" "" "" "" "" "" "2957.6" "2757.8" "2876.7" "3201.0" "2763.5" "3270.1" "2511.9" "2908.4" "3011.9" "1075.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5771737938610614120" "False" "High" "IsMasterProtein" "Q9UPN7" "Serine/threonine-protein phosphatase 6 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP6R1 PE=1 SV=5" "0.000" "False" "108.691" "29" "19" "33" "19" "881" "96.7" "4.55" "142.90" "19" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf04499" "22870" "ENSG00000105063" "PPP6R1" "hsa:22870; Q2M2H3; Q504V2; Q6NVJ6; Q9BU97; Q9UPN7" "" "COPII-mediated vesicle transport" "1" "0" "1.000" "0.910" "1.005" "1.036" "0.973" "1.012" "1.027" "0.996" "0.910" "1950.1" "1949.4" "1774.3" "1959.0" "2020.4" "1898.5" "1974.0" "2001.9" "1941.5" "1774.1" "" "" "" "" "" "" "" "" "" "" "1753.4" "1577.4" "1604.9" "1912.3" "1667.3" "1898.5" "1478.1" "1768.2" "1737.2" "633.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905591351439676835" "False" "High" "IsMasterProtein" "P50995" "Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1" "0.000" "False" "108.617" "34" "18" "40" "18" "505" "54.4" "7.65" "150.83" "18" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00191" "311" "ENSG00000122359" "ANXA11" "B4DVE7; hsa:311; P50995" "" "" "0" "0" "1.029" "0.976" "0.974" "1.019" "0.942" "1.027" "0.973" "0.999" "1.477" "3257.0" "3351.8" "3179.2" "3173.3" "3318.0" "3068.1" "3344.4" "3168.7" "3254.4" "4811.1" "" "" "" "" "" "" "" "" "" "" "2928.4" "2712.1" "2875.7" "3097.6" "2738.1" "3068.1" "2504.2" "2798.8" "2912.0" "1717.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1964393919908826502" "False" "High" "IsMasterProtein" "Q96I99" "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG2 PE=1 SV=2" "0.000" "False" "108.490" "48" "19" "38" "19" "432" "46.5" "6.39" "158.89" "19" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00549, Pf08442" "8801" "ENSG00000172340" "SUCLG2" "C9JVT2; hsa:8801; O95195; Q6NUH7; Q86VX8; Q8WUQ1; Q96I99" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Mitochondrial protein degradation; Citric acid cycle (TCA cycle)" "5" "0" "0.978" "0.954" "0.971" "1.018" "0.928" "1.002" "1.005" "0.958" "0.814" "4177.5" "4085.3" "3986.7" "4056.7" "4252.7" "3874.8" "4186.1" "4199.0" "4002.2" "3401.8" "" "" "" "" "" "" "" "" "" "" "3756.0" "3305.7" "3606.1" "3959.9" "3509.4" "3874.8" "3134.5" "3708.8" "3581.1" "1214.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6048249212605468111" "False" "High" "IsMasterProtein" "P30876" "DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens OX=9606 GN=POLR2B PE=1 SV=1" "0.000" "False" "108.289" "26" "28" "44" "28" "1174" "133.8" "6.87" "151.89" "28" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "5431" "ENSG00000047315" "POLR2B" "A8K1A8; hsa:5431; P30876; Q8IZ61" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.995" "0.931" "0.961" "0.940" "0.924" "0.961" "0.967" "0.938" "0.951" "3627.8" "3611.1" "3376.6" "3485.5" "3408.9" "3353.6" "3485.1" "3508.4" "3401.2" "3449.5" "" "" "" "" "" "" "" "" "" "" "3261.7" "2922.0" "3054.3" "3402.3" "2813.1" "3353.6" "2609.6" "3098.9" "3043.3" "1231.4" "24" "24" "24" "24" "24" "24" "24" "24" "24" "24" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4997024104720897707" "False" "High" "IsMasterProtein" "Q9BZK7" "F-box-like/WD repeat-containing protein TBL1XR1 OS=Homo sapiens OX=9606 GN=TBL1XR1 PE=1 SV=1" "0.000" "False" "107.884" "50" "16" "34" "10" "514" "55.6" "5.55" "171.42" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "79718" "ENSG00000177565" "TBL1XR1" "D3DNQ9; hsa:79718; Q14DC3; Q9BZK7; Q9H2I1; Q9H9A1" "Rett syndrome" "HCMV Early Events; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "20" "5" "1.027" "0.992" "1.011" "1.036" "0.937" "1.062" "1.022" "0.976" "0.915" "2998.2" "3078.2" "2975.3" "3031.9" "3105.0" "2807.9" "3184.8" "3063.6" "2926.6" "2742.5" "" "" "" "" "" "" "" "" "" "" "2695.7" "2490.8" "2691.3" "2959.6" "2562.3" "2807.9" "2384.7" "2706.0" "2618.7" "979.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2598946853791074460" "False" "High" "IsMasterProtein" "Q9Y295" "Developmentally-regulated GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=DRG1 PE=1 SV=1" "0.000" "False" "107.865" "57" "19" "39" "18" "367" "40.5" "8.90" "143.50" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01926, Pf02824, Pf16897" "4733" "ENSG00000185721" "DRG1" "B2RDS8; hsa:4733; Q6FGP8; Q8WW69; Q9UGF2; Q9Y295" "" "Protein hydroxylation" "1" "1" "1.005" "1.012" "0.961" "1.028" "0.958" "0.983" "0.984" "1.001" "0.797" "4037.2" "4059.4" "4086.6" "3878.3" "4152.1" "3868.2" "3970.5" "3971.3" "4040.5" "3218.3" "" "" "" "" "" "" "" "" "" "" "3629.8" "3284.7" "3696.4" "3785.8" "3426.4" "3868.2" "2973.0" "3507.7" "3615.4" "1148.9" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175952193399053833" "False" "High" "IsMasterProtein" "P50748" "Kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=KNTC1 PE=1 SV=1" "0.000" "False" "107.791" "15" "34" "38" "33" "2209" "250.6" "5.97" "128.50" "34" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10493" "9735" "ENSG00000184445" "KNTC1" "A7E2C4; B3KSG2; hsa:9735; P50748" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.034" "0.972" "0.965" "1.052" "0.972" "1.026" "0.985" "0.992" "1.177" "1833.8" "1896.7" "1782.5" "1770.1" "1929.4" "1782.0" "1882.1" "1806.8" "1819.5" "2158.1" "" "" "" "" "" "" "" "" "" "" "1648.8" "1534.7" "1612.3" "1727.9" "1592.2" "1782.0" "1409.3" "1595.9" "1628.1" "770.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2550625188107110862" "False" "High" "IsMasterProtein" "P14550" "Aldo-keto reductase family 1 member A1 OS=Homo sapiens OX=9606 GN=AKR1A1 PE=1 SV=3" "0.000" "False" "107.767" "62" "20" "62" "19" "325" "36.6" "6.79" "208.74" "20" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00248" "10327" "ENSG00000117448" "AKR1A1" "A8KAL8; D3DQ04; hsa:10327; P14550; Q6IAZ4" "Benzo(a)pyrene metabolism; Metapathway biotransformation Phase I and II" "Glutathione conjugation; Formation of xylulose-5-phosphate" "4" "2" "0.999" "0.997" "0.984" "1.017" "0.976" "0.998" "0.992" "0.995" "0.808" "5552.9" "5546.0" "5534.9" "5464.7" "5649.7" "5417.7" "5543.6" "5510.8" "5524.3" "4486.7" "" "" "" "" "" "" "" "" "" "" "4992.6" "4487.6" "5006.5" "5334.3" "4662.3" "5417.7" "4150.9" "4867.5" "4943.1" "1601.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7294352330531963904" "False" "High" "IsMasterProtein" "Q99439" "Calponin-2 OS=Homo sapiens OX=9606 GN=CNN2 PE=1 SV=4" "0.000" "False" "107.749" "43" "12" "57" "12" "309" "33.7" "7.33" "209.13" "12" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00402" "1265" "ENSG00000064666" "CNN2" "A5D8U8; A6NFI4; D6W5X9; hsa:1265; Q92578; Q99439" "Myometrial relaxation and contraction pathways; Burn wound healing" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "4" "0" "0.953" "0.963" "0.993" "0.975" "0.976" "0.979" "1.012" "1.010" "1.047" "7050.3" "6717.0" "6791.9" "7000.7" "6872.9" "6881.6" "6900.9" "7136.0" "7118.6" "7379.6" "" "" "" "" "" "" "" "" "" "" "6338.9" "5435.2" "6143.5" "6833.6" "5671.6" "6881.6" "5167.2" "6303.0" "6369.6" "2634.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469246297971201094" "False" "High" "IsMasterProtein" "Q86TU7" "Actin-histidine N-methyltransferase OS=Homo sapiens OX=9606 GN=SETD3 PE=1 SV=1" "0.000" "False" "107.700" "41" "23" "39" "22" "594" "67.2" "5.96" "144.38" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00856, Pf09273" "84193" "ENSG00000183576" "SETD3" "A0PJU3; A5PLP0; B4DZE8; hsa:84193; Q0VAQ2; Q659C0; Q86TU7; Q86TU8; Q96GY9; Q9H5U5" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "1.157" "0.990" "0.936" "1.001" "0.967" "0.994" "1.001" "0.993" "0.787" "3124.5" "3614.1" "3092.6" "2925.2" "3127.4" "3022.0" "3105.0" "3128.6" "3103.4" "2457.9" "" "" "" "" "" "" "" "" "" "" "2809.3" "2924.4" "2797.4" "2855.4" "2580.8" "3022.0" "2325.0" "2763.4" "2776.9" "877.4" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5207555211981118816" "False" "High" "IsMasterProtein" "Q08J23" "RNA cytosine C(5)-methyltransferase NSUN2 OS=Homo sapiens OX=9606 GN=NSUN2 PE=1 SV=2" "0.000" "False" "107.469" "41" "24" "37" "24" "767" "86.4" "6.77" "143.80" "24" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "54888" "ENSG00000037474" "NSUN2" "A8K529; B2RNR4; B3KP09; B4DQW2; G3V1R4; hsa:54888; Q08J23; Q9BVN4; Q9H858; Q9NXD9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.963" "0.848" "1.030" "0.968" "0.873" "1.105" "0.919" "0.821" "2.589" "2976.6" "2867.8" "2525.1" "3065.3" "2882.6" "2599.6" "3288.5" "2734.2" "2442.7" "7705.5" "" "" "" "" "" "" "" "" "" "" "2676.2" "2320.6" "2284.0" "2992.2" "2378.8" "2599.6" "2462.4" "2415.0" "2185.7" "2750.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9099132526023132947" "False" "High" "IsMasterProtein" "Q9Y6D5" "Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens OX=9606 GN=ARFGEF2 PE=1 SV=3" "0.000" "False" "107.363" "17" "27" "32" "16" "1785" "201.9" "6.33" "124.62" "27" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01369, Pf09324, Pf12783, Pf16213, Pf20252" "10564" "ENSG00000124198" "ARFGEF2" "hsa:10564; Q5TFT9; Q9NTS1; Q9Y6D5" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "0" "1.064" "1.028" "0.925" "1.013" "0.963" "0.999" "0.979" "0.992" "1.165" "1216.1" "1294.2" "1250.2" "1124.9" "1232.0" "1170.9" "1214.6" "1190.7" "1205.9" "1416.4" "" "" "" "" "" "" "" "" "" "" "1093.4" "1047.2" "1130.8" "1098.1" "1016.7" "1170.9" "909.4" "1051.7" "1079.0" "505.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6708028902102911891" "False" "High" "IsMasterProtein" "P21281" "V-type proton ATPase subunit B, brain isoform OS=Homo sapiens OX=9606 GN=ATP6V1B2 PE=1 SV=3" "0.000" "False" "107.012" "42" "17" "43" "17" "511" "56.5" "5.81" "171.58" "17" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00006, Pf02874" "526" "ENSG00000147416" "ATP6V1B2" "B2R5Z3; D3DSQ5; hsa:526; P21281; Q14544; Q15859; Q96IR0" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "1.046" "1.031" "1.021" "1.025" "1.023" "1.006" "1.011" "1.030" "0.814" "3729.7" "3902.1" "3843.6" "3809.0" "3821.7" "3815.4" "3751.7" "3769.9" "3840.6" "3037.5" "" "" "" "" "" "" "" "" "" "" "3353.3" "3157.5" "3476.7" "3718.1" "3153.8" "3815.4" "2809.2" "3329.8" "3436.5" "1084.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599424746602695209" "False" "High" "IsMasterProtein" "Q9ULE6" "Paladin OS=Homo sapiens OX=9606 GN=PALD1 PE=1 SV=3" "0.000" "False" "106.885" "34" "27" "40" "27" "856" "96.7" "6.54" "142.27" "27" "" "cytosol;other cell component" "other molecular function" "Pf14566" "27143" "ENSG00000107719" "PALD1" "B2RMS1; B9EGC6; hsa:27143; Q5JTK7; Q5JTK8; Q9ULE6" "" "" "0" "0" "1.044" "1.032" "1.009" "1.054" "0.995" "1.049" "0.998" "1.011" "0.837" "2759.5" "2882.0" "2849.2" "2783.0" "2908.3" "2745.2" "2894.2" "2754.4" "2789.4" "2310.0" "" "" "" "" "" "" "" "" "" "" "2481.1" "2332.0" "2577.2" "2716.6" "2400.0" "2745.2" "2167.1" "2432.9" "2495.9" "824.6" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6077570543552496726" "False" "High" "IsMasterProtein" "Q8N1G4" "Leucine-rich repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=LRRC47 PE=1 SV=1" "0.000" "False" "106.867" "45" "21" "41" "21" "583" "63.4" "8.28" "151.01" "21" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00560, Pf13855" "57470" "ENSG00000130764" "LRRC47" "hsa:57470; Q8N1G4; Q9ULN5" "" "" "0" "0" "1.086" "1.023" "1.011" "1.051" "1.039" "1.065" "1.026" "0.996" "0.863" "1879.0" "2040.3" "1921.4" "1899.3" "1975.1" "1953.1" "2001.3" "1927.8" "1871.6" "1621.0" "" "" "" "" "" "" "" "" "" "" "1689.4" "1650.9" "1738.0" "1854.0" "1629.9" "1953.1" "1498.6" "1702.7" "1674.7" "578.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6669951735420197648" "False" "High" "IsMasterProtein" "O00154" "Cytosolic acyl coenzyme A thioester hydrolase OS=Homo sapiens OX=9606 GN=ACOT7 PE=1 SV=3" "0.000" "False" "106.533" "45" "14" "38" "14" "380" "41.8" "8.54" "150.82" "14" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03061" "11332" "ENSG00000097021" "ACOT7" "A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; hsa:11332; O00154; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "1.070" "1.070" "1.017" "1.055" "1.040" "1.022" "1.011" "1.096" "0.957" "2696.6" "2886.4" "2885.4" "2742.2" "2843.6" "2805.0" "2755.3" "2726.0" "2955.0" "2581.3" "" "" "" "" "" "" "" "" "" "" "2424.5" "2335.6" "2609.9" "2676.8" "2346.6" "2805.0" "2063.1" "2407.7" "2644.1" "921.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8782574511401724651" "False" "High" "IsMasterProtein" "Q06124" "Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens OX=9606 GN=PTPN11 PE=1 SV=3" "0.000" "False" "106.489" "50" "25" "49" "25" "593" "68.0" "7.30" "168.77" "25" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00102" "5781" "ENSG00000179295" "PTPN11" "A8K1D9; hsa:5781; Q06124; Q96HD7" "IL-5 signaling pathway; Heart development; IL-1 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Embryonic stem cell pluripotency pathways; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Fragile X syndrome; Cancer immunotherapy by CTLA4 blockade; Cancer immunotherapy by PD-1 blockade; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; Insulin signaling; IL-2 signaling pathway; Angiotensin II receptor type 1 pathway; Kallmann syndrome; Orexin receptor pathway; GDNF signaling; Interferon type I signaling pathways; Type II interferon signaling; T-cell receptor signaling pathway" "PIP3 activates AKT signaling; GPVI-mediated activation cascade; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PD-1 signaling; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Signal regulatory protein family interactions; Constitutive Signaling by Aberrant PI3K in Cancer; Interleukin-3, Interleukin-5 and GM-CSF signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; PI3K Cascade; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; Interleukin-6 signaling; Signaling by Leptin; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Signaling by CSF3 (G-CSF); GAB1 signalosome; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; FRS-mediated FGFR1 signaling; PI-3K cascade:FGFR2; FRS-mediated FGFR2 signaling; FRS-mediated FGFR3 signaling; PI-3K cascade:FGFR3; FRS-mediated FGFR4 signaling; PI-3K cascade:FGFR4; Activated NTRK2 signals through FRS2 and FRS3; Spry regulation of FGF signaling; MAPK3 (ERK1) activation; MAPK1 (ERK2) activation; Prolactin receptor signaling; Interleukin-20 family signaling; Netrin mediated repulsion signals; Interleukin-37 signaling; Signaling by FLT3 ITD and TKD mutants; Platelet sensitization by LDL; PECAM1 interactions; CTLA4 inhibitory signaling; MET activates PTPN11; STAT5 activation downstream of FLT3 ITD mutants; Regulation of RUNX1 Expression and Activity; STAT5 Activation" "91" "0" "0.984" "0.966" "1.000" "0.997" "0.965" "0.972" "0.981" "0.987" "0.790" "2913.2" "2865.3" "2812.8" "2914.5" "2903.5" "2810.5" "2832.8" "2857.8" "2874.4" "2300.4" "" "" "" "" "" "" "" "" "" "" "2619.2" "2318.5" "2544.3" "2844.9" "2396.0" "2810.5" "2121.1" "2524.2" "2572.0" "821.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100878916131084887" "False" "High" "IsMasterProtein" "P36871" "Phosphoglucomutase-1 OS=Homo sapiens OX=9606 GN=PGM1 PE=1 SV=3" "0.000" "False" "106.420" "42" "22" "39" "22" "562" "61.4" "6.76" "143.82" "22" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf02878, Pf02879, Pf02880" "5236" "ENSG00000079739" "PGM1" "B2R5N9; B4DPV0; hsa:5236; P36871; Q16105; Q16106; Q5BKZ9; Q6NW22; Q86U74; Q96J40; Q9NTY4" "Ectoderm differentiation; Clear cell renal cell carcinoma pathways; Glycogen synthesis and degradation; Opioid receptor pathways; Disorders of galactose metabolism ; Disorders of fructose metabolism; UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Galactose catabolism; Defective PGM1 causes PGM1-CDG" "13" "0" "0.990" "1.021" "1.019" "1.039" "1.001" "1.012" "0.959" "0.984" "0.821" "4206.9" "4166.2" "4294.0" "4284.9" "4370.0" "4211.9" "4259.4" "4034.8" "4138.2" "3452.1" "" "" "" "" "" "" "" "" "" "" "3782.4" "3371.1" "3884.0" "4182.6" "3606.2" "4211.9" "3189.3" "3563.8" "3702.8" "1232.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857902194460077614" "False" "High" "IsMasterProtein" "Q13535" "Serine/threonine-protein kinase ATR OS=Homo sapiens OX=9606 GN=ATR PE=1 SV=3" "0.000" "False" "106.379" "13" "30" "34" "30" "2644" "301.2" "7.43" "114.19" "30" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08064" "545" "ENSG00000175054" "ATR" "hsa:545; Q13535; Q59HB2; Q7KYL3; Q93051; Q9BXK4" "miRNA regulation of DNA damage response; Cell cycle; ATR signaling; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; NIPBL role in DNA damage - Cornelia de Lange syndrome; DNA damage response" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic synapsis; Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "19" "0" "1.017" "1.008" "0.956" "1.029" "0.954" "0.989" "1.021" "1.008" "0.887" "2293.2" "2331.5" "2312.2" "2191.5" "2359.6" "2187.7" "2267.9" "2341.7" "2311.7" "2034.7" "" "" "" "" "" "" "" "" "" "" "2061.8" "1886.6" "2091.5" "2139.2" "1947.2" "2187.7" "1698.2" "2068.3" "2068.5" "726.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981355964815445657" "False" "High" "IsMasterProtein" "P35611" "Alpha-adducin OS=Homo sapiens OX=9606 GN=ADD1 PE=1 SV=2" "0.000" "False" "106.227" "28" "15" "35" "15" "737" "80.9" "5.83" "136.72" "15" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "118" "ENSG00000087274" "ADD1" "A2A3N8; A2A3P0; B4DI79; D3DVR3; D3DVR4; D3DVR5; hsa:118; P35611; Q13734; Q14729; Q16156; Q86XM2; Q9UJB6" "" "XBP1(S) activates chaperone genes; Caspase-mediated cleavage of cytoskeletal proteins; Miscellaneous transport and binding events" "3" "0" "0.989" "0.971" "0.958" "1.030" "1.019" "0.974" "0.999" "1.027" "0.805" "2395.0" "2369.1" "2324.4" "2294.1" "2466.9" "2439.7" "2333.4" "2392.4" "2460.5" "1928.1" "" "" "" "" "" "" "" "" "" "" "2153.3" "1917.0" "2102.5" "2239.4" "2035.7" "2439.7" "1747.2" "2113.2" "2201.6" "688.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5905184492137342602" "False" "High" "IsMasterProtein" "P08559" "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Homo sapiens OX=9606 GN=PDHA1 PE=1 SV=3" "0.000" "False" "106.193" "48" "21" "49" "21" "390" "43.3" "8.06" "151.23" "21" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00676" "5160" "ENSG00000131828" "PDHA1" "A5YVE9; B2R5P7; B7Z3T7; B7Z3X5; hsa:5160; P08559; Q53H41; Q5JPT8; Q9NP12; Q9UBJ8; Q9UBU0; Q9UNG4; Q9UNG5" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Lipid metabolism pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Thiamine metabolic pathways; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Acetylcholine synthesis; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "17" "0" "0.985" "0.934" "1.001" "0.942" "0.899" "0.991" "0.945" "0.942" "1.032" "3634.3" "3578.6" "3393.0" "3637.8" "3422.8" "3267.1" "3602.2" "3435.9" "3424.8" "3749.5" "" "" "" "" "" "" "" "" "" "" "3267.6" "2895.7" "3069.1" "3551.0" "2824.6" "3267.1" "2697.2" "3034.8" "3064.5" "1338.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4198310778640922638" "False" "High" "IsMasterProtein" "Q9Y3F4" "Serine-threonine kinase receptor-associated protein OS=Homo sapiens OX=9606 GN=STRAP PE=1 SV=1" "0.000" "False" "105.822" "57" "16" "41" "16" "350" "38.4" "5.12" "172.18" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00400" "11171" "ENSG00000023734" "STRAP" "B2R5S5; B4DNJ6; hsa:11171; Q5TZT4; Q9NTK0; Q9UQC8; Q9Y3F4" "TGF-beta signaling pathway; Epithelial to mesenchymal transition in colorectal cancer" "Downregulation of TGF-beta receptor signaling" "3" "0" "0.992" "0.981" "1.014" "0.998" "0.928" "1.000" "1.005" "0.989" "1.278" "5816.8" "5772.6" "5705.1" "5899.5" "5806.6" "5395.4" "5816.6" "5846.9" "5752.3" "7431.5" "" "" "" "" "" "" "" "" "" "" "5229.9" "4671.0" "5160.5" "5758.8" "4791.7" "5395.4" "4355.4" "5164.4" "5147.1" "2652.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-990721738298047914" "False" "High" "IsMasterProtein" "O00299" "Chloride intracellular channel protein 1 OS=Homo sapiens OX=9606 GN=CLIC1 PE=1 SV=4" "0.000" "False" "105.699" "74" "13" "63" "13" "241" "26.9" "5.17" "286.77" "13" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf13409, Pf13410" "1192" "ENSG00000206394; ENSG00000213719; ENSG00000223639; ENSG00000226248; ENSG00000226417; ENSG00000226651; ENSG00000230685" "CLIC1" "hsa:1192; O00299; Q15089; Q502X1" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.981" "0.965" "0.955" "1.007" "0.930" "0.981" "0.981" "0.998" "0.805" "5645.4" "5535.4" "5446.2" "5391.1" "5685.0" "5250.5" "5538.0" "5536.0" "5635.6" "4546.0" "" "" "" "" "" "" "" "" "" "" "5075.8" "4479.0" "4926.3" "5262.5" "4691.3" "5250.5" "4146.7" "4889.8" "5042.7" "1622.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8919089648667332764" "False" "High" "IsMasterProtein" "Q6NZY4" "Zinc finger CCHC domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZCCHC8 PE=1 SV=2" "0.000" "False" "105.531" "38" "19" "32" "19" "707" "78.5" "4.87" "144.49" "19" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00098, Pf04046" "55596" "ENSG00000033030" "ZCCHC8" "hsa:55596; Q6NZY4; Q7L2P6; Q8N2K5; Q96SK7; Q9NSS2; Q9NSS3" "" "" "0" "0" "0.995" "0.969" "1.011" "0.999" "0.991" "1.009" "1.033" "0.947" "0.886" "2767.0" "2752.6" "2681.0" "2796.5" "2763.2" "2743.0" "2792.2" "2857.1" "2620.7" "2450.3" "" "" "" "" "" "" "" "" "" "" "2487.8" "2227.3" "2425.1" "2729.8" "2280.3" "2743.0" "2090.7" "2523.6" "2345.0" "874.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480641512252917896" "False" "High" "IsMasterProtein" "Q9NRF8" "CTP synthase 2 OS=Homo sapiens OX=9606 GN=CTPS2 PE=1 SV=1" "0.000" "False" "105.374" "38" "21" "43" "18" "586" "65.6" "6.90" "157.23" "21" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00117, Pf06418, Pf07722" "56474" "ENSG00000047230" "CTPS2" "B3KWM2; hsa:56474; Q9BRI0; Q9H809; Q9H8K9; Q9NRF8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.037" "0.991" "0.966" "1.025" "0.948" "1.024" "0.985" "0.995" "0.799" "3026.3" "3137.2" "2999.5" "2922.3" "3102.3" "2868.7" "3099.3" "2980.3" "3012.7" "2418.0" "" "" "" "" "" "" "" "" "" "" "2721.0" "2538.5" "2713.2" "2852.5" "2560.1" "2868.7" "2320.7" "2632.4" "2695.8" "863.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2546736599525709996" "False" "High" "IsMasterProtein" "Q8N1G2" "Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Homo sapiens OX=9606 GN=CMTR1 PE=1 SV=1" "0.000" "False" "105.351" "33" "26" "39" "25" "835" "95.3" "7.05" "135.90" "26" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01585, Pf01728" "23070" "ENSG00000137200" "CMTR1" "A8K949; hsa:23070; Q14670; Q8N1G2; Q96FJ9" "" "" "0" "1" "1.044" "1.094" "0.985" "1.063" "1.077" "1.041" "1.020" "1.097" "0.966" "3984.5" "4158.0" "4359.1" "3925.4" "4235.2" "4292.5" "4147.1" "4064.9" "4371.0" "3850.1" "" "" "" "" "" "" "" "" "" "" "3582.4" "3364.5" "3942.9" "3831.7" "3495.0" "4292.5" "3105.3" "3590.4" "3911.1" "1374.4" "25" "25" "25" "25" "25" "25" "25" "25" "25" "25" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5122002380756434681" "False" "High" "IsMasterProtein" "Q9Y6E2" "eIF5-mimic protein 1 OS=Homo sapiens OX=9606 GN=BZW2 PE=1 SV=1" "0.000" "False" "105.054" "46" "22" "59" "18" "419" "48.1" "6.68" "218.12" "22" "other biological processes" "other cell component" "" "Pf02020" "28969" "ENSG00000136261" "BZW2" "A4D123; hsa:28969; Q3B779; Q96JW5; Q9H3F7; Q9Y6E2" "" "" "0" "4" "1.005" "1.009" "0.984" "1.024" "0.952" "1.040" "1.008" "0.960" "0.923" "7360.2" "7393.4" "7425.3" "7241.9" "7536.8" "7008.3" "7657.7" "7418.1" "7069.0" "6793.5" "" "" "" "" "" "" "" "" "" "" "6617.5" "5982.5" "6716.4" "7069.1" "6219.5" "7008.3" "5733.9" "6552.1" "6325.3" "2425.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9112301912693417232" "False" "High" "IsMasterProtein" "Q13332" "Receptor-type tyrosine-protein phosphatase S OS=Homo sapiens OX=9606 GN=PTPRS PE=1 SV=3" "0.000" "False" "104.888" "18" "23" "31" "20" "1948" "216.9" "6.46" "133.65" "23" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00102, Pf07679, Pf13927" "5802" "ENSG00000105426" "PTPRS" "hsa:5802; O75255; O75870; Q13332; Q15718; Q16341; Q2M3R7" "" "Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases; ECM proteoglycans; Signaling by NTRK3 (TRKC)" "4" "2" "0.990" "0.986" "1.007" "0.996" "0.965" "0.946" "0.981" "0.987" "0.878" "2140.4" "2119.9" "2110.1" "2155.0" "2131.5" "2066.0" "2025.1" "2099.4" "2112.6" "1878.9" "" "" "" "" "" "" "" "" "" "" "1924.4" "1715.3" "1908.6" "2103.5" "1758.9" "2066.0" "1516.4" "1854.3" "1890.3" "670.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1853475733980272119" "False" "High" "IsMasterProtein" "P17858" "ATP-dependent 6-phosphofructokinase, liver type OS=Homo sapiens OX=9606 GN=PFKL PE=1 SV=6" "0.000" "False" "104.751" "31" "21" "46" "15" "780" "85.0" "7.50" "174.54" "21" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "kinase activity;other molecular function" "Pf00365" "5211" "ENSG00000141959" "PFKL" "hsa:5211; P17858; Q96A64; Q96IH4; Q9BR91" "Photodynamic therapy-induced HIF-1 survival signaling; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Insulin signaling; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Glycolysis" "9" "0" "0.989" "0.953" "0.915" "0.975" "0.907" "0.968" "0.984" "0.990" "0.787" "2476.9" "2450.9" "2359.6" "2265.7" "2413.8" "2245.7" "2397.4" "2438.0" "2451.1" "1950.0" "" "" "" "" "" "" "" "" "" "" "2227.0" "1983.2" "2134.4" "2211.6" "1992.0" "2245.7" "1795.1" "2153.4" "2193.3" "696.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962903921157164287" "False" "High" "IsMasterProtein" "Q8IYD1" "Eukaryotic peptide chain release factor GTP-binding subunit ERF3B OS=Homo sapiens OX=9606 GN=GSPT2 PE=1 SV=2" "0.000" "False" "104.692" "22" "16" "50" "2" "628" "68.8" "5.43" "179.46" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf07145" "23708" "ENSG00000189369" "GSPT2" "hsa:23708; Q8IYD1; Q9H909; Q9NVY0; Q9NY44" "Translation factors" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "5" "0" "1.069" "1.083" "0.975" "1.074" "1.027" "0.923" "1.017" "1.097" "0.739" "253.7" "271.2" "274.8" "247.3" "272.5" "260.4" "234.1" "258.1" "278.4" "187.4" "" "" "" "" "" "" "" "" "" "" "228.1" "219.4" "248.6" "241.4" "224.9" "260.4" "175.3" "227.9" "249.1" "66.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-508494988063673287" "False" "High" "IsMasterProtein" "Q9NXG2" "THUMP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=THUMPD1 PE=1 SV=2" "0.000" "False" "104.666" "58" "17" "35" "17" "353" "39.3" "7.88" "135.79" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02926" "55623" "ENSG00000066654" "THUMPD1" "hsa:55623; Q9BWC3; Q9NXG2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "0.986" "0.967" "0.976" "1.007" "0.952" "0.964" "1.005" "0.977" "0.757" "2566.4" "2530.6" "2480.6" "2505.2" "2583.7" "2443.8" "2474.1" "2580.4" "2508.5" "1943.1" "" "" "" "" "" "" "" "" "" "" "2307.4" "2047.7" "2243.7" "2445.4" "2132.1" "2443.8" "1852.5" "2279.2" "2244.6" "693.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8008274239603490952" "False" "High" "IsMasterProtein" "P51991" "Heterogeneous nuclear ribonucleoprotein A3 OS=Homo sapiens OX=9606 GN=HNRNPA3 PE=1 SV=2" "0.000" "False" "104.660" "44" "18" "88" "16" "378" "39.6" "9.01" "301.88" "18" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "220988" "ENSG00000170144" "HNRNPA3" "D3DPF4; hsa:220988; P51991; Q53RW7; Q6URK5" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.058" "0.994" "1.204" "0.965" "1.174" "1.044" "1.070" "1.001" "1.019" "4649.3" "4916.9" "4620.6" "5598.8" "4488.3" "5457.2" "4854.7" "4972.5" "4653.2" "4735.9" "" "" "" "" "" "" "" "" "" "" "4180.2" "3978.6" "4179.5" "5465.2" "3703.9" "5457.2" "3635.1" "4392.0" "4163.6" "1690.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5568233219206595783" "False" "High" "IsMasterProtein" "Q9ULT8" "E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens OX=9606 GN=HECTD1 PE=1 SV=4" "0.000" "False" "104.647" "14" "29" "37" "29" "2610" "289.2" "5.35" "125.26" "29" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf00632, Pf06701, Pf07738, Pf12796, Pf18410" "25831" "ENSG00000092148" "HECTD1" "D3DS86; hsa:25831; Q6P445; Q86VJ1; Q96F34; Q9UFZ7; Q9ULT8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.015" "1.039" "1.012" "1.008" "1.009" "1.034" "0.964" "1.033" "1.572" "2391.0" "2427.5" "2484.7" "2419.3" "2411.3" "2413.0" "2473.0" "2306.1" "2469.8" "3759.6" "" "" "" "" "" "" "" "" "" "" "2149.8" "1964.3" "2247.5" "2361.5" "1989.8" "2413.0" "1851.7" "2036.9" "2210.0" "1342.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6456635449604072928" "False" "High" "IsMasterProtein" "P30419" "Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens OX=9606 GN=NMT1 PE=1 SV=2" "0.000" "False" "104.573" "37" "16" "45" "16" "496" "56.8" "7.80" "158.21" "16" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01233, Pf02799" "4836" "ENSG00000136448" "NMT1" "A8K7C1; hsa:4836; P30419; Q9UE09" "" "Inactivation, recovery and regulation of the phototransduction cascade; Late Phase of HIV Life Cycle; Activation, myristolyation of BID and translocation to mitochondria" "3" "0" "0.973" "0.972" "0.953" "0.961" "0.982" "0.967" "0.945" "0.952" "0.776" "4380.0" "4261.5" "4256.6" "4175.0" "4210.9" "4299.6" "4233.9" "4139.7" "4167.9" "3400.3" "" "" "" "" "" "" "" "" "" "" "3938.0" "3448.3" "3850.2" "4075.4" "3474.9" "4299.6" "3170.2" "3656.4" "3729.4" "1213.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6370225409205057848" "False" "High" "IsMasterProtein" "Q9UHX1" "Poly(U)-binding-splicing factor PUF60 OS=Homo sapiens OX=9606 GN=PUF60 PE=1 SV=1" "0.000" "False" "104.564" "38" "18" "37" "18" "559" "59.8" "5.29" "146.01" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "22827" "ENSG00000179950" "PUF60" "A8K8K8; hsa:22827; Q969E7; Q96D94; Q96H63; Q99628; Q9NZA0; Q9UHX1; Q9UJY7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.032" "1.018" "0.995" "1.022" "1.007" "1.042" "0.992" "1.009" "1.016" "3036.5" "3132.7" "3091.8" "3022.3" "3103.1" "3057.7" "3165.6" "3011.6" "3063.9" "3085.9" "" "" "" "" "" "" "" "" "" "" "2730.1" "2534.9" "2796.6" "2950.2" "2560.8" "3057.7" "2370.3" "2660.0" "2741.5" "1101.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6856624260157841827" "False" "High" "IsMasterProtein" "O60256" "Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Homo sapiens OX=9606 GN=PRPSAP2 PE=1 SV=1" "0.000" "False" "104.458" "61" "17" "35" "15" "369" "40.9" "7.44" "155.39" "17" "other metabolic processes;developmental processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5636" "ENSG00000141127" "PRPSAP2" "B4E1M8; B4E329; B7ZKZ1; E7EMY2; hsa:5636; O60256; Q6IAS2" "" "" "0" "3" "1.052" "0.998" "1.002" "1.008" "0.972" "0.985" "1.027" "1.017" "0.808" "2340.0" "2461.0" "2334.3" "2344.9" "2358.7" "2273.6" "2304.7" "2404.1" "2380.4" "1891.0" "" "" "" "" "" "" "" "" "" "" "2103.9" "1991.3" "2111.4" "2289.0" "1946.4" "2273.6" "1725.7" "2123.5" "2129.9" "675.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "124053754926249858" "False" "High" "IsMasterProtein" "Q9UBF2" "Coatomer subunit gamma-2 OS=Homo sapiens OX=9606 GN=COPG2 PE=1 SV=1" "0.000" "False" "104.293" "31" "23" "38" "20" "871" "97.6" "5.81" "135.78" "23" "transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01602, Pf08752, Pf16381" "26958" "ENSG00000158623" "COPG2" "A6NH74; hsa:26958; Q2NLA0; Q54AC3; Q8WVW8; Q9UBF2" "" "COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic" "2" "0" "1.023" "0.990" "0.962" "1.008" "0.982" "1.005" "1.016" "0.968" "0.822" "2907.3" "2974.5" "2877.2" "2795.8" "2929.3" "2855.2" "2922.6" "2954.1" "2815.3" "2389.2" "" "" "" "" "" "" "" "" "" "" "2613.9" "2406.9" "2602.5" "2729.1" "2417.4" "2855.2" "2188.3" "2609.2" "2519.1" "852.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "170444545631699205" "False" "High" "IsMasterProtein" "Q9Y4E1" "WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5" "0.000" "False" "104.193" "23" "25" "34" "3" "1341" "147.1" "4.81" "126.79" "25" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15255" "253725" "ENSG00000172661" "WASHC2C" "A0A096LPC5; B4DZQ6; B9EK53; F5H0J6; F5H871; hsa:253725; Q5SQU4; Q5SQU5; Q7L521; Q9UG79; Q9Y4E1" "" "" "0" "0" "0.931" "0.996" "0.969" "0.898" "0.908" "0.915" "1.038" "1.026" "1.178" "259.1" "241.2" "258.0" "251.1" "232.6" "235.2" "237.0" "268.8" "265.8" "305.1" "" "" "" "" "" "" "" "" "" "" "232.9" "195.1" "233.3" "245.2" "191.9" "235.2" "177.4" "237.4" "237.8" "108.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4706681870966743539" "False" "High" "IsMasterProtein" "Q9BWU0" "Kanadaptin OS=Homo sapiens OX=9606 GN=SLC4A1AP PE=1 SV=2" "0.000" "False" "104.082" "45" "25" "30" "25" "742" "82.8" "5.10" "118.96" "25" "" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00035, Pf00498" "22950" "ENSG00000163798" "SLC4A1AP" "A0A087X0M4; A6NJ39; hsa:22950; Q4KMT1; Q4KMX0; Q7Z5Q9; Q9BWU0; Q9NVN2" "" "" "0" "0" "0.995" "1.041" "1.001" "1.036" "1.056" "1.025" "1.041" "1.048" "0.971" "2239.2" "2227.1" "2330.6" "2242.5" "2320.3" "2365.0" "2295.0" "2331.7" "2347.0" "2173.6" "" "" "" "" "" "" "" "" "" "" "2013.3" "1802.1" "2108.1" "2189.0" "1914.8" "2365.0" "1718.4" "2059.5" "2100.1" "775.9" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5341813448089902722" "False" "High" "IsMasterProtein" "P16885" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 OS=Homo sapiens OX=9606 GN=PLCG2 PE=1 SV=4" "0.000" "False" "103.972" "23" "27" "43" "27" "1265" "147.8" "6.64" "141.36" "27" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00017, Pf00018, Pf00168, Pf00387, Pf00388, Pf16457" "5336" "ENSG00000197943" "PLCG2" "D3DUL3; hsa:5336; P16885; Q3ZTS2; Q59H45; Q969T5" "Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Microglia pathogen phagocytosis pathway; GPR40 pathway; Ras signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; EGFR tyrosine kinase inhibitor resistance; GDNF signaling; 2q13 copy number variation syndrome; ErbB signaling pathway" "Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; CLEC7A (Dectin-1) signaling; Toll Like Receptor 4 (TLR4) Cascade; GPVI-mediated activation cascade; DAP12 signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells; Erythropoietin activates Phospholipase C gamma (PLCG); Dectin-2 family" "30" "0" "1.003" "1.021" "0.939" "0.990" "0.986" "1.032" "0.719" "0.973" "11.040" "2639.1" "2647.4" "2695.2" "2478.9" "2611.8" "2601.4" "2723.9" "1898.8" "2567.2" "29137.4" "" "" "" "" "" "" "" "" "" "" "2372.8" "2142.2" "2437.9" "2419.8" "2155.3" "2601.4" "2039.6" "1677.1" "2297.1" "10401.2" "22" "22" "22" "22" "22" "22" "22" "22" "22" "22" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8586713697824146806" "False" "High" "IsMasterProtein" "P46379" "Large proline-rich protein BAG6 OS=Homo sapiens OX=9606 GN=BAG6 PE=1 SV=2" "0.000" "False" "103.956" "21" "19" "36" "19" "1132" "119.3" "5.60" "140.48" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;other molecular function" "Pf00240, Pf12057, Pf20960" "7917" "ENSG00000096155; ENSG00000204463; ENSG00000227761; ENSG00000228760; ENSG00000229524; ENSG00000233348; ENSG00000234651" "BAG6" "A2ADJ7; A3KQ42; A3KQ44; A6NGY6; A6PWF7; B0UX84; B4DZ12; B4E3V4; E7EMZ4; F8VXY4; hsa:7917; O95874; P46379; Q5HYL9; Q5SQ35; Q5SQ36; Q5SQ37; Q5SQ41; Q5SRP8; Q5SRP9; Q5STC1; Q5STX1; Q5STX3; Q96SA6; Q9BCN4" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.041" "1.026" "1.021" "1.069" "1.001" "0.979" "1.023" "1.020" "1.001" "1744.8" "1816.8" "1789.4" "1782.1" "1865.3" "1746.0" "1707.9" "1784.3" "1780.5" "1746.9" "" "" "" "" "" "" "" "" "" "" "1568.7" "1470.1" "1618.5" "1739.6" "1539.3" "1746.0" "1278.8" "1576.0" "1593.1" "623.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570733689934674061" "False" "High" "IsMasterProtein" "P61106" "Ras-related protein Rab-14 OS=Homo sapiens OX=9606 GN=RAB14 PE=1 SV=4" "0.000" "False" "103.912" "80" "15" "52" "13" "215" "23.9" "6.21" "172.80" "15" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "51552" "ENSG00000119396" "RAB14" "B3KR31; hsa:51552; P35287; P61106; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane" "7" "2" "1.010" "1.030" "1.015" "1.040" "0.976" "1.013" "0.984" "1.018" "0.684" "4283.6" "4327.4" "4413.1" "4346.3" "4452.9" "4182.6" "4338.0" "4215.0" "4361.4" "2930.5" "" "" "" "" "" "" "" "" "" "" "3851.4" "3501.6" "3991.8" "4242.6" "3674.6" "4182.6" "3248.2" "3722.9" "3902.5" "1046.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3813032805198607075" "False" "High" "IsMasterProtein" "Q9NVA2" "Septin-11 OS=Homo sapiens OX=9606 GN=SEPTIN11 PE=1 SV=3" "0.000" "False" "103.675" "42" "16" "62" "8" "429" "49.4" "6.81" "206.15" "16" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00735" "55752" "ENSG00000138758" "SEPTIN11" "B7Z7Z6; E9KL32; hsa:55752; Q4W5G1; Q7L4N1; Q96SP1; Q9NVA2; Q9UFY9" "22q11.2 copy number variation syndrome" "" "1" "8" "1.046" "1.043" "1.043" "1.060" "1.015" "1.010" "1.012" "1.030" "0.842" "4403.4" "4605.0" "4593.6" "4593.2" "4668.4" "4470.4" "4446.6" "4458.0" "4537.2" "3708.9" "" "" "" "" "" "" "" "" "" "" "3959.1" "3726.2" "4155.1" "4483.6" "3852.4" "4470.4" "3329.5" "3937.6" "4059.8" "1324.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877503792566385355" "False" "High" "IsMasterProtein" "O75822" "Eukaryotic translation initiation factor 3 subunit J OS=Homo sapiens OX=9606 GN=EIF3J PE=1 SV=2" "0.000" "False" "103.653" "57" "17" "37" "17" "258" "29.0" "4.83" "151.11" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08597" "8669" "ENSG00000104131" "EIF3J" "B4DUI3; F5H425; hsa:8669; O75822; Q9BUD2; Q9H8Q2; Q9UI65" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.904" "0.963" "0.913" "0.970" "1.012" "0.931" "0.973" "0.998" "0.720" "4059.0" "3671.1" "3907.9" "3705.4" "3937.2" "4109.0" "3780.0" "3949.1" "4048.9" "2922.2" "" "" "" "" "" "" "" "" "" "" "3649.4" "2970.5" "3534.8" "3617.0" "3249.0" "4109.0" "2830.4" "3488.1" "3622.9" "1043.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92619424180281671" "False" "High" "IsMasterProtein" "Q14141" "Septin-6 OS=Homo sapiens OX=9606 GN=SEPTIN6 PE=1 SV=4" "0.000" "False" "103.450" "43" "15" "59" "7" "434" "49.7" "6.67" "204.33" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "23157" "ENSG00000125354" "SEPTIN6" "hsa:23157; Q14141; Q5JTK0; Q969W5; Q96A13; Q96GR1; Q96P86; Q96P87" "2q37 copy number variation syndrome" "" "1" "0" "0.982" "0.962" "1.056" "1.030" "0.952" "1.061" "1.036" "1.042" "0.785" "1546.6" "1518.0" "1487.2" "1632.5" "1593.7" "1472.2" "1641.4" "1602.8" "1611.6" "1214.6" "" "" "" "" "" "" "" "" "" "" "1390.6" "1228.3" "1345.2" "1593.6" "1315.1" "1472.2" "1229.0" "1415.7" "1442.1" "433.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644721245290312006" "False" "High" "IsMasterProtein" "Q9UNS2" "COP9 signalosome complex subunit 3 OS=Homo sapiens OX=9606 GN=COPS3 PE=1 SV=3" "0.000" "False" "103.387" "38" "12" "43" "12" "423" "47.8" "6.65" "173.13" "12" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf21215" "8533" "ENSG00000141030" "COPS3" "B2R683; B4DY81; hsa:8533; O43191; Q7LDR6; Q9UNS2" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Formation of TC-NER Pre-Incision Complex; Neddylation; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "6" "0" "0.990" "0.990" "1.001" "1.004" "0.992" "1.006" "1.032" "0.993" "0.879" "3958.3" "3918.5" "3916.7" "3962.9" "3972.7" "3928.5" "3981.5" "4083.7" "3930.1" "3480.3" "" "" "" "" "" "" "" "" "" "" "3558.9" "3170.7" "3542.8" "3868.4" "3278.4" "3928.5" "2981.2" "3607.0" "3516.6" "1242.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8809117759024256443" "False" "High" "IsMasterProtein" "P29692" "Elongation factor 1-delta OS=Homo sapiens OX=9606 GN=EEF1D PE=1 SV=5" "0.000" "False" "103.189" "63" "15" "62" "12" "281" "31.1" "5.01" "230.55" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00736, Pf10587" "1936" "ENSG00000104529; ENSG00000273594" "EEF1D" "B4DDU4; D3DWK3; E9PBQ9; hsa:1936; P29692; Q4VBZ6; Q969J1; Q96I38" "Translation factors" "Eukaryotic Translation Elongation" "2" "3" "0.950" "0.934" "0.993" "0.993" "0.959" "1.055" "1.020" "0.966" "0.844" "3666.0" "3484.0" "3425.1" "3640.2" "3641.3" "3515.9" "3866.1" "3740.7" "3543.0" "3092.9" "" "" "" "" "" "" "" "" "" "" "3296.1" "2819.1" "3098.1" "3553.4" "3004.8" "3515.9" "2894.8" "3304.0" "3170.3" "1104.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219195248541824635" "False" "High" "IsMasterProtein" "Q92609" "TBC1 domain family member 5 OS=Homo sapiens OX=9606 GN=TBC1D5 PE=1 SV=1" "0.000" "False" "103.013" "36" "23" "37" "23" "795" "88.9" "6.54" "128.76" "23" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9779" "ENSG00000131374" "TBC1D5" "A6NP25; C9JP52; hsa:9779; Q92609" "" "" "0" "0" "0.986" "0.968" "0.978" "1.037" "0.966" "0.971" "1.012" "0.958" "1.029" "2152.9" "2123.6" "2084.3" "2105.6" "2233.2" "2080.7" "2089.8" "2178.7" "2061.7" "2214.6" "" "" "" "" "" "" "" "" "" "" "1935.7" "1718.4" "1885.4" "2055.4" "1842.9" "2080.7" "1564.8" "1924.4" "1844.8" "790.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-504997331308259812" "False" "High" "IsMasterProtein" "P17174" "Aspartate aminotransferase, cytoplasmic OS=Homo sapiens OX=9606 GN=GOT1 PE=1 SV=3" "0.000" "False" "102.852" "53" "17" "47" "17" "413" "46.2" "7.01" "181.69" "17" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00155" "2805" "ENSG00000120053" "GOT1" "B2R6R7; B7Z7E9; hsa:2805; P17174; Q5VW80" "Alanine and aspartate metabolism; Trans-sulfuration pathway; Amino acid metabolism; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; TCA cycle in senescence; Neuroinflammation and glutamatergic signaling; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Gluconeogenesis; Aspartate and asparagine metabolism; Methionine salvage pathway" "11" "0" "0.994" "1.009" "1.030" "1.037" "0.973" "1.000" "0.984" "1.025" "0.800" "4553.9" "4527.7" "4594.0" "4689.8" "4720.8" "4429.6" "4555.9" "4481.5" "4669.5" "3644.5" "" "" "" "" "" "" "" "" "" "" "4094.4" "3663.7" "4155.4" "4577.9" "3895.7" "4429.6" "3411.4" "3958.4" "4178.3" "1301.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2982172693089125932" "False" "High" "IsMasterProtein" "P28066" "Proteasome subunit alpha type-5 OS=Homo sapiens OX=9606 GN=PSMA5 PE=1 SV=3" "0.000" "False" "102.816" "63" "11" "52" "11" "241" "26.4" "4.79" "227.12" "11" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5686" "ENSG00000143106" "PSMA5" "B2R8F6; B4E2V4; hsa:5686; P28066; Q3T1C1; Q6IBF7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Downstream TCR signaling; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.005" "0.969" "1.069" "0.991" "0.987" "1.022" "1.063" "1.006" "0.896" "4460.6" "4484.0" "4324.3" "4769.1" "4421.4" "4404.5" "4560.7" "4740.4" "4488.8" "3996.0" "" "" "" "" "" "" "" "" "" "" "4010.5" "3628.3" "3911.4" "4655.3" "3648.6" "4404.5" "3415.0" "4187.0" "4016.5" "1426.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4388967430464997560" "False" "High" "IsMasterProtein" "P43034" "Platelet-activating factor acetylhydrolase IB subunit beta OS=Homo sapiens OX=9606 GN=PAFAH1B1 PE=1 SV=2" "0.000" "False" "102.814" "54" "19" "44" "18" "410" "46.6" "7.37" "180.65" "19" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08513" "5048" "ENSG00000007168" "PAFAH1B1" "B2R7Q7; hsa:5048; P43034; Q8WZ88; Q8WZ89" "Wnt signaling pathway and pluripotency; Ciliary landscape; Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "18" "1" "0.970" "0.980" "1.024" "0.961" "0.984" "0.974" "0.967" "0.958" "0.846" "6184.8" "5997.0" "6063.5" "6333.6" "5943.1" "6083.3" "6025.9" "5983.6" "5922.5" "5232.1" "" "" "" "" "" "" "" "" "" "" "5560.7" "4852.6" "5484.6" "6182.4" "4904.3" "6083.3" "4512.1" "5285.1" "5299.4" "1867.7" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7459111357476572255" "False" "High" "IsMasterProtein" "Q8NFY9" "Kelch repeat and BTB domain-containing protein 8 OS=Homo sapiens OX=9606 GN=KBTBD8 PE=1 SV=2" "0.000" "False" "102.767" "35" "21" "32" "21" "601" "68.8" "6.29" "127.68" "21" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "84541" "ENSG00000163376" "KBTBD8" "B4DTW6; hsa:84541; Q8NFY9; Q96JI5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.026" "1.054" "0.960" "1.036" "1.005" "1.023" "0.974" "1.053" "1.011" "2045.3" "2098.3" "2155.1" "1963.6" "2118.2" "2055.3" "2091.9" "1991.7" "2153.5" "2068.6" "" "" "" "" "" "" "" "" "" "" "1838.9" "1697.9" "1949.3" "1916.7" "1748.0" "2055.3" "1566.4" "1759.2" "1926.9" "738.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5275540959932174837" "False" "High" "IsMasterProtein" "Q14847" "LIM and SH3 domain protein 1 OS=Homo sapiens OX=9606 GN=LASP1 PE=1 SV=2" "0.000" "False" "102.745" "46" "13" "75" "13" "261" "29.7" "7.05" "226.61" "13" "transport" "cytoskeleton;other cell component" "transporter activity;cytoskeletal activity;other molecular function" "Pf00412, Pf00880, Pf14604" "3927" "ENSG00000002834" "LASP1" "B4DGQ0; hsa:3927; Q14847; Q96ED2; Q96IG0" "17q12 copy number variation syndrome" "" "1" "0" "0.938" "0.943" "0.942" "0.946" "0.953" "0.972" "0.999" "0.907" "0.775" "4136.0" "3879.8" "3901.4" "3894.8" "3912.6" "3941.3" "4022.2" "4130.3" "3749.6" "3207.1" "" "" "" "" "" "" "" "" "" "" "3718.6" "3139.4" "3529.0" "3801.9" "3228.7" "3941.3" "3011.7" "3648.1" "3355.1" "1144.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773020118127395212" "False" "High" "IsMasterProtein" "P30740" "Leukocyte elastase inhibitor OS=Homo sapiens OX=9606 GN=SERPINB1 PE=1 SV=1" "0.000" "False" "102.735" "49" "18" "42" "17" "379" "42.7" "6.28" "159.24" "18" "cell cycle OR cell proliferation;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf00079" "1992" "ENSG00000021355" "SERPINB1" "A8K5L2; B4DNT0; hsa:1992; P30740; Q53FB9; Q5W0E1; Q9UDF8" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "1.002" "1.019" "1.038" "1.004" "1.041" "0.977" "0.988" "1.056" "0.813" "3274.1" "3280.7" "3337.7" "3397.5" "3286.4" "3408.4" "3197.3" "3235.5" "3457.6" "2660.9" "" "" "" "" "" "" "" "" "" "" "2943.7" "2654.6" "3019.1" "3316.4" "2712.0" "3408.4" "2394.1" "2857.8" "3093.8" "949.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "677526654360538548" "False" "High" "IsMasterProtein" "Q99733" "Nucleosome assembly protein 1-like 4 OS=Homo sapiens OX=9606 GN=NAP1L4 PE=1 SV=1" "0.000" "False" "102.664" "47" "14" "52" "12" "375" "42.8" "4.69" "185.09" "14" "cell organization and biogenesis" "nucleus;other cell component" "other molecular function" "Pf00956" "4676" "ENSG00000205531; ENSG00000273562" "NAP1L4" "B2R6J4; F5HFY4; hsa:4676; Q99733" "" "" "0" "0" "0.956" "1.006" "0.978" "0.993" "0.970" "0.985" "0.999" "1.008" "0.864" "3089.4" "2952.9" "3107.0" "3020.1" "3066.7" "2997.9" "3041.6" "3086.0" "3113.2" "2670.7" "" "" "" "" "" "" "" "" "" "" "2777.7" "2389.4" "2810.4" "2948.1" "2530.7" "2997.9" "2277.5" "2725.8" "2785.7" "953.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088552440920446999" "False" "High" "IsMasterProtein" "Q9Y570" "Protein phosphatase methylesterase 1 OS=Homo sapiens OX=9606 GN=PPME1 PE=1 SV=3" "0.000" "False" "102.649" "45" "16" "38" "16" "386" "42.3" "5.97" "143.71" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12697" "51400" "ENSG00000214517" "PPME1" "B3KMU6; B5MEE7; hsa:51400; J3QT22; Q8WYG8; Q9NVT5; Q9UI18; Q9Y570" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "1.009" "1.011" "0.977" "1.051" "0.997" "0.999" "1.058" "1.045" "0.805" "4258.2" "4295.5" "4303.0" "4160.7" "4476.1" "4245.2" "4255.4" "4503.3" "4451.7" "3428.2" "" "" "" "" "" "" "" "" "" "" "3828.5" "3475.8" "3892.2" "4061.4" "3693.8" "4245.2" "3186.4" "3977.6" "3983.3" "1223.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141032543915842811" "False" "High" "IsMasterProtein" "Q13011" "Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Homo sapiens OX=9606 GN=ECH1 PE=1 SV=2" "0.000" "False" "102.564" "59" "15" "47" "15" "328" "35.8" "8.00" "177.68" "15" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00378" "1891" "ENSG00000104823; ENSG00000282853" "ECH1" "A8K745; hsa:1891; Q13011; Q8WVX0; Q96EZ9" "Fatty acid biosynthesis; IL-18 signaling pathway" "Peroxisomal protein import; Mitochondrial protein degradation" "4" "0" "1.034" "1.039" "1.067" "1.042" "0.999" "1.044" "0.985" "1.053" "0.824" "4608.6" "4764.9" "4787.0" "4915.4" "4800.3" "4604.0" "4812.2" "4540.7" "4852.6" "3796.3" "" "" "" "" "" "" "" "" "" "" "4143.5" "3855.6" "4330.0" "4798.1" "3961.3" "4604.0" "3603.3" "4010.6" "4342.0" "1355.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2351772574129659372" "False" "High" "IsMasterProtein" "P35269" "General transcription factor IIF subunit 1 OS=Homo sapiens OX=9606 GN=GTF2F1 PE=1 SV=2" "0.000" "False" "102.481" "45" "17" "43" "17" "517" "58.2" "7.49" "174.83" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf05793" "2962" "ENSG00000125651" "GTF2F1" "B2RCS0; hsa:2962; P35269; Q9BWN0" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Viral Messenger RNA Synthesis; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA polymerase II transcribes snRNA genes; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "32" "0" "0.974" "0.989" "0.973" "0.978" "0.990" "0.968" "1.005" "0.976" "0.806" "4118.6" "4013.3" "4072.0" "4006.1" "4030.0" "4078.4" "3988.0" "4141.0" "4020.8" "3318.8" "" "" "" "" "" "" "" "" "" "" "3703.0" "3247.4" "3683.3" "3910.5" "3325.6" "4078.4" "2986.1" "3657.6" "3597.8" "1184.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5432753500567823498" "False" "High" "IsMasterProtein" "O75390" "Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2" "0.000" "False" "102.464" "29" "14" "85" "14" "466" "51.7" "8.32" "241.80" "14" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00285" "1431" "ENSG00000062485" "CS" "hsa:1431; O75390; Q71UT9; Q7KZH0; Q96FZ8; Q9BWN8" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Fluoroacetic acid toxicity; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import; Mitochondrial protein degradation" "7" "0" "1.007" "0.983" "0.995" "0.990" "1.015" "0.995" "1.033" "0.987" "1.041" "5666.6" "5705.7" "5571.2" "5637.5" "5607.5" "5752.2" "5637.2" "5852.1" "5591.8" "5900.1" "" "" "" "" "" "" "" "" "" "" "5094.8" "4616.9" "5039.3" "5503.0" "4627.4" "5752.2" "4221.0" "5168.9" "5003.5" "2106.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2836831182499166141" "False" "High" "IsMasterProtein" "O00148" "ATP-dependent RNA helicase DDX39A OS=Homo sapiens OX=9606 GN=DDX39A PE=1 SV=2" "0.000" "False" "102.303" "46" "20" "55" "8" "427" "49.1" "5.68" "180.98" "20" "RNA metabolism OR transcription;other metabolic processes;transport" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "10212" "ENSG00000123136" "DDX39A" "B1Q2N1; hsa:10212; O00148; Q8N5M0; Q9BVP6; Q9H5W0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.009" "0.971" "1.051" "1.079" "0.943" "1.164" "0.983" "0.993" "2.646" "762.8" "769.7" "740.7" "802.1" "823.1" "719.4" "887.6" "750.1" "757.4" "2018.7" "" "" "" "" "" "" "" "" "" "" "685.9" "622.8" "670.0" "783.0" "679.2" "719.4" "664.6" "662.5" "677.7" "720.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2201882454177381815" "False" "High" "IsMasterProtein" "P63241" "Eukaryotic translation initiation factor 5A-1 OS=Homo sapiens OX=9606 GN=EIF5A PE=1 SV=2" "0.000" "False" "102.282" "68" "10" "95" "10" "154" "16.8" "5.24" "414.98" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01287, Pf21485" "1984" "ENSG00000132507; ENSG00000288145" "EIF5A" "A8K9A0; D3DTP2; hsa:1984; P10159; P63241; Q16182; Q7L7L3; Q7Z4L1; Q9D0G2" "Translation factors; eIF5A regulation in response to inhibition of the nuclear export system" "Hypusine synthesis from eIF5A-lysine" "3" "0" "0.885" "0.931" "0.977" "0.967" "0.962" "0.973" "0.983" "0.968" "1.039" "9597.6" "8494.9" "8937.0" "9379.8" "9280.6" "9235.1" "9343.2" "9434.2" "9290.0" "9972.0" "" "" "" "" "" "" "" "" "" "" "8629.2" "6873.7" "8083.8" "9156.0" "7658.5" "9235.1" "6996.0" "8332.9" "8312.6" "3559.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-15854148761745197" "False" "High" "IsMasterProtein" "Q6IN85" "Serine/threonine-protein phosphatase 4 regulatory subunit 3A OS=Homo sapiens OX=9606 GN=PPP4R3A PE=1 SV=1" "0.000" "False" "102.278" "27" "20" "37" "20" "833" "95.3" "4.94" "124.89" "20" "stress response" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf04802" "55671" "ENSG00000100796" "PPP4R3A" "hsa:55671; Q69YK6; Q6IN85; Q86U23; Q86YI7; Q8IVG1; Q9H3F1; Q9H7U8; Q9NV01; Q9NWP1" "16p11.2 proximal deletion syndrome" "" "1" "0" "0.998" "0.964" "0.968" "1.036" "0.921" "0.993" "1.002" "0.981" "0.968" "3637.2" "3629.8" "3508.0" "3521.8" "3767.9" "3349.6" "3611.8" "3644.2" "3567.2" "3520.7" "" "" "" "" "" "" "" "" "" "" "3270.2" "2937.1" "3173.1" "3437.7" "3109.3" "3349.6" "2704.4" "3218.8" "3191.9" "1256.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4143955501491186019" "False" "High" "IsMasterProtein" "P55084" "Trifunctional enzyme subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=HADHB PE=1 SV=3" "0.000" "False" "102.199" "43" "17" "45" "17" "474" "51.3" "9.41" "132.34" "17" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi" "nucleic acid binding activity;other molecular function" "Pf00108, Pf02803" "3032" "ENSG00000138029" "HADHB" "B2RB16; B4E2W0; hsa:3032; O14969; P55084; Q53TA6; Q96C77; Q9H3F5; Q9T2V8" "Fatty acid beta-oxidation; Valproic acid pathway; Female steroid hormones in cardiomyocyte energy metabolism; Sudden infant death syndrome (SIDS) susceptibility pathways" "Acyl chain remodeling of CL; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of myristoyl-CoA to lauroyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA; Beta oxidation of palmitoyl-CoA to myristoyl-CoA" "12" "0" "0.983" "0.958" "0.979" "0.930" "0.888" "0.935" "0.943" "0.949" "0.844" "4291.2" "4217.4" "4110.6" "4201.5" "3991.3" "3809.5" "4014.0" "4047.0" "4071.8" "3621.1" "" "" "" "" "" "" "" "" "" "" "3858.2" "3412.6" "3718.2" "4101.2" "3293.7" "3809.5" "3005.6" "3574.5" "3643.4" "1292.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7053379414769105992" "False" "High" "IsMasterProtein" "Q92905" "COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4" "0.000" "False" "102.052" "51" "13" "36" "13" "334" "37.6" "6.54" "147.47" "13" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf18323" "10987" "ENSG00000121022" "COPS5" "hsa:10987; O15386; Q6AW95; Q86WQ4; Q92905; Q9BQ17" "TGF-beta signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "1.018" "1.042" "1.082" "1.026" "1.006" "1.012" "1.023" "1.029" "0.813" "3157.6" "3214.3" "3291.6" "3415.9" "3238.2" "3176.1" "3194.4" "3229.8" "3248.3" "2568.2" "" "" "" "" "" "" "" "" "" "" "2839.0" "2600.9" "2977.4" "3334.4" "2672.2" "3176.1" "2391.9" "2852.8" "2906.6" "916.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "980650416735823729" "False" "High" "IsMasterProtein" "Q9UHD1" "Cysteine and histidine-rich domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHORDC1 PE=1 SV=2" "0.000" "False" "101.967" "59" "19" "42" "19" "332" "37.5" "7.87" "170.87" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf04968, Pf04969" "26973" "ENSG00000110172; ENSG00000285023" "CHORDC1" "B2R6P8; hsa:26973; Q6IN49; Q8WVL9; Q9H3D6; Q9UHD1" "" "" "0" "0" "1.044" "0.981" "1.049" "1.038" "1.109" "0.986" "1.088" "1.038" "0.962" "4932.1" "5148.2" "4839.4" "5174.9" "5119.1" "5468.3" "4861.1" "5364.1" "5118.7" "4745.8" "" "" "" "" "" "" "" "" "" "" "4434.4" "4165.8" "4377.4" "5051.4" "4224.4" "5468.3" "3639.9" "4737.9" "4580.2" "1694.1" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-91982353768306611" "False" "High" "IsMasterProtein" "P00492" "Hypoxanthine-guanine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=HPRT1 PE=1 SV=2" "0.000" "False" "101.895" "76" "13" "53" "13" "218" "24.6" "6.68" "211.53" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00156" "3251" "ENSG00000165704" "HPRT1" "A6NHF0; B2R8M9; hsa:3251; P00492" "Mesodermal commitment pathway" "Azathioprine ADME; Purine salvage; Defective HPRT1 disrupts guanine and hypoxanthine salvage" "4" "0" "0.971" "0.984" "0.986" "0.996" "0.937" "0.972" "1.014" "0.992" "0.768" "6343.5" "6158.6" "6241.6" "6252.5" "6320.5" "5944.3" "6169.0" "6429.3" "6293.5" "4871.2" "" "" "" "" "" "" "" "" "" "" "5703.4" "4983.3" "5645.8" "6103.3" "5215.8" "5944.3" "4619.2" "5678.8" "5631.4" "1738.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6735907081845110604" "False" "High" "IsMasterProtein" "Q9Y2L1" "Exosome complex exonuclease RRP44 OS=Homo sapiens OX=9606 GN=DIS3 PE=1 SV=2" "0.000" "False" "101.876" "24" "20" "31" "20" "958" "108.9" "7.14" "115.17" "20" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00773, Pf13638, Pf17215, Pf17216, Pf17849" "22894" "ENSG00000083520" "DIS3" "A6NI21; B2RBL2; hsa:22894; Q5W0P7; Q5W0P8; Q658Z7; Q7Z481; Q8WWI2; Q9UG36; Q9Y2L1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.056" "0.969" "0.980" "1.067" "0.936" "1.026" "0.873" "0.907" "3.033" "1895.7" "2001.2" "1837.5" "1857.9" "2022.4" "1773.6" "1944.3" "1654.7" "1718.6" "5748.8" "" "" "" "" "" "" "" "" "" "" "1704.4" "1619.3" "1662.1" "1813.6" "1668.9" "1773.6" "1455.8" "1461.6" "1537.8" "2052.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6641856841102683489" "False" "High" "IsMasterProtein" "P62826" "GTP-binding nuclear protein Ran OS=Homo sapiens OX=9606 GN=RAN PE=1 SV=3" "0.000" "False" "101.875" "56" "14" "81" "14" "216" "24.4" "7.49" "313.77" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5901" "ENSG00000132341" "RAN" "A8K3Z8; hsa:5901; P17080; P28746; P28747; P62826; Q6IPB2; Q86V08; Q8NI90; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9" "Androgen receptor signaling pathway; miRNA biogenesis; 22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Nuclear import of Rev protein; Transcriptional regulation by small RNAs; tRNA processing in the nucleus; Regulation of cholesterol biosynthesis by SREBP (SREBF); MicroRNA (miRNA) biogenesis; Postmitotic nuclear pore complex (NPC) reformation" "11" "0" "1.050" "1.050" "1.227" "1.063" "1.004" "1.042" "1.046" "1.095" "0.833" "6984.4" "7335.2" "7333.1" "8570.7" "7422.3" "7013.6" "7280.6" "7306.7" "7646.0" "5818.0" "" "" "" "" "" "" "" "" "" "" "6279.6" "5935.4" "6633.1" "8366.2" "6125.0" "7013.6" "5451.5" "6453.8" "6841.5" "2076.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7900354501110065761" "False" "High" "IsMasterProtein" "O00170" "AH receptor-interacting protein OS=Homo sapiens OX=9606 GN=AIP PE=1 SV=3" "0.000" "False" "101.805" "61" "15" "33" "15" "330" "37.6" "6.42" "146.57" "15" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "9049" "ENSG00000110711" "AIP" "A0SZW3; A0SZW4; A0SZW5; A0SZW6; G9I2H4; hsa:9049; O00170; Q2M3Q2; Q99606" "Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway" "Aryl hydrocarbon receptor signalling; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "1.000" "0.959" "1.008" "1.038" "0.999" "1.055" "1.047" "0.996" "1.020" "3646.5" "3645.9" "3497.8" "3676.5" "3786.3" "3644.3" "3848.5" "3819.6" "3633.6" "3718.4" "" "" "" "" "" "" "" "" "" "" "3278.5" "2950.1" "3163.9" "3588.7" "3124.5" "3644.3" "2881.6" "3373.7" "3251.4" "1327.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516272036315922492" "False" "High" "IsMasterProtein" "Q15637" "Splicing factor 1 OS=Homo sapiens OX=9606 GN=SF1 PE=1 SV=4" "0.000" "False" "101.796" "23" "11" "50" "11" "639" "68.3" "8.98" "192.66" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00098, Pf16275" "7536" "ENSG00000168066" "SF1" "B7Z1Q1; C9JJE2; hsa:7536; Q14818; Q14819; Q15637; Q15913; Q8IY00; Q92744; Q92745; Q969H7; Q9BW01; Q9UEI0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.937" "0.909" "0.983" "0.987" "0.966" "0.967" "0.995" "0.923" "0.759" "4974.8" "4661.5" "4521.0" "4888.4" "4908.1" "4806.2" "4810.5" "4951.8" "4590.8" "3777.2" "" "" "" "" "" "" "" "" "" "" "4472.8" "3771.9" "4089.4" "4771.7" "4050.3" "4806.2" "3602.0" "4373.7" "4107.8" "1348.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101901840121098087" "False" "High" "IsMasterProtein" "P52788" "Spermine synthase OS=Homo sapiens OX=9606 GN=SMS PE=1 SV=2" "0.000" "False" "101.607" "59" "17" "36" "17" "366" "41.2" "5.02" "152.43" "17" "other metabolic processes" "cytosol" "other molecular function" "Pf01564, Pf17284, Pf17950" "6611" "ENSG00000102172" "SMS" "A6NHA7; A6NI34; B2R9M0; hsa:6611; O00544; P52788; Q9UQS1" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "1.019" "1.017" "1.046" "1.061" "0.938" "1.074" "1.068" "1.070" "0.869" "2193.5" "2234.5" "2231.5" "2294.8" "2328.3" "2056.5" "2355.5" "2343.2" "2347.3" "1907.2" "" "" "" "" "" "" "" "" "" "" "1972.2" "1808.1" "2018.5" "2240.0" "1921.3" "2056.5" "1763.7" "2069.7" "2100.4" "680.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040349963704556613" "False" "High" "IsMasterProtein" "P30154" "Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform OS=Homo sapiens OX=9606 GN=PPP2R1B PE=1 SV=3" "0.000" "False" "101.558" "39" "20" "45" "12" "601" "66.2" "4.94" "159.48" "20" "other biological processes" "other membranes;other cell component" "enzyme regulator activity" "Pf02985, Pf13646" "5519" "ENSG00000137713" "PPP2R1B" "A8MY67; B0YJ69; B4DGQ6; B4DK91; B4DWW5; F8W8G1; hsa:5519; O75620; P30154; Q8NHV8" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DARPP-32 events; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; PKR-mediated signaling; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; Cyclin D associated events in G1; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Cyclin A/B1/B2 associated events during G2/M transition; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; MASTL Facilitates Mitotic Progression; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling; Inhibition of replication initiation of damaged DNA by RB1/E2F1; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "40" "0" "0.976" "1.055" "0.934" "1.005" "1.011" "1.073" "0.981" "1.007" "1.961" "1278.6" "1247.4" "1348.4" "1194.4" "1285.6" "1292.5" "1372.4" "1254.0" "1287.8" "2507.7" "" "" "" "" "" "" "" "" "" "" "1149.6" "1009.4" "1219.7" "1165.9" "1060.9" "1292.5" "1027.6" "1107.6" "1152.4" "895.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154520297388586765" "False" "High" "IsMasterProtein" "Q9HCC0" "Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC2 PE=1 SV=1" "0.000" "False" "101.556" "42" "19" "29" "19" "563" "61.3" "7.68" "117.79" "19" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01039" "64087" "ENSG00000131844" "MCCC2" "A6NIY9; hsa:64087; Q96C27; Q9HCC0; Q9Y4L7" "" "Biotin transport and metabolism; Branched-chain amino acid catabolism; Defective HLCS causes multiple carboxylase deficiency" "3" "0" "0.979" "0.944" "1.013" "0.987" "0.937" "0.920" "0.984" "0.974" "0.831" "2394.5" "2343.2" "2261.1" "2426.5" "2362.7" "2244.2" "2203.8" "2356.2" "2333.4" "1989.8" "" "" "" "" "" "" "" "" "" "" "2152.9" "1896.0" "2045.2" "2368.6" "1949.7" "2244.2" "1650.2" "2081.2" "2087.9" "710.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697106387219567458" "False" "High" "IsMasterProtein" "Q6P2E9" "Enhancer of mRNA-decapping protein 4 OS=Homo sapiens OX=9606 GN=EDC4 PE=1 SV=1" "0.000" "False" "101.530" "23" "25" "42" "25" "1401" "151.6" "5.86" "145.40" "25" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf16529, Pf21289" "23644" "ENSG00000038358" "EDC4" "A6NGM1; A8K4T4; hsa:23644; Q13025; Q13826; Q6P2E9; Q6ZR12; Q7Z6H7" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.017" "1.006" "0.987" "1.064" "1.016" "1.028" "0.993" "1.048" "1.058" "2147.6" "2185.1" "2161.1" "2118.9" "2285.8" "2182.5" "2208.8" "2132.9" "2250.4" "2271.4" "" "" "" "" "" "" "" "" "" "" "1930.9" "1768.1" "1954.8" "2068.3" "1886.3" "2182.5" "1653.9" "1883.9" "2013.6" "810.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6056072514061180880" "False" "High" "IsMasterProtein" "Q9Y2D5" "PALM2-AKAP2 fusion protein OS=Homo sapiens OX=9606 GN=PALM2AKAP2 PE=1 SV=4" "0.000" "False" "101.499" "22" "21" "40" "21" "1103" "122.0" "5.06" "148.60" "21" "" "plasma membrane;other membranes" "" "Pf03285, Pf15304" "445815" "ENSG00000157654" "PALM2AKAP2" "A9Z1X9; B1ALX9; B2RTU4; B3KQ00; B4DTZ2; B7ZW07; B9EJB5; hsa:445815; Q8IXS6; Q8N9D5; Q96DU1; Q9UG26; Q9Y2D5" "" "" "0" "0" "0.944" "0.961" "0.973" "0.979" "0.958" "0.960" "0.980" "0.940" "0.831" "4399.3" "4153.0" "4227.5" "4280.1" "4307.4" "4216.0" "4222.5" "4312.9" "4135.0" "3655.7" "" "" "" "" "" "" "" "" "" "" "3955.4" "3360.5" "3823.9" "4178.0" "3554.5" "4216.0" "3161.7" "3809.5" "3699.9" "1305.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193290723324093172" "False" "High" "IsMasterProtein" "P33316" "Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=DUT PE=1 SV=4" "0.000" "False" "101.452" "56" "13" "64" "13" "252" "26.5" "9.36" "241.00" "13" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00692" "1854" "ENSG00000128951" "DUT" "A8K650; B4DPR5; hsa:1854; O14785; P33316; Q16708; Q16860; Q6FHN1; Q6NSA3; Q96Q81" "Pyrimidine metabolism" "" "1" "0" "0.983" "1.023" "1.016" "1.004" "1.061" "1.045" "1.040" "1.064" "0.862" "3585.4" "3526.1" "3667.7" "3642.4" "3600.6" "3805.0" "3747.3" "3730.1" "3813.4" "3090.2" "" "" "" "" "" "" "" "" "" "" "3223.6" "2853.2" "3317.5" "3555.5" "2971.3" "3805.0" "2805.9" "3294.6" "3412.2" "1103.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585562482268553685" "False" "High" "IsMasterProtein" "O15372" "Eukaryotic translation initiation factor 3 subunit H OS=Homo sapiens OX=9606 GN=EIF3H PE=1 SV=1" "0.000" "False" "101.215" "55" "15" "38" "15" "352" "39.9" "6.54" "135.51" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf19445" "8667" "ENSG00000147677" "EIF3H" "hsa:8667; O15372" "Translation factors; VEGFA-VEGFR2 signaling; Measles virus infection; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "10" "0" "1.003" "0.987" "0.932" "0.975" "1.009" "0.985" "0.953" "0.960" "1.350" "3165.4" "3175.2" "3124.5" "2949.2" "3085.4" "3192.4" "3119.1" "3016.8" "3038.9" "4271.7" "" "" "" "" "" "" "" "" "" "" "2846.0" "2569.3" "2826.3" "2878.8" "2546.2" "3192.4" "2335.5" "2664.6" "2719.2" "1524.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-478504765432675351" "False" "High" "IsMasterProtein" "P30520" "Adenylosuccinate synthetase isozyme 2 OS=Homo sapiens OX=9606 GN=ADSS2 PE=1 SV=3" "0.000" "False" "101.134" "48" "18" "37" "18" "456" "50.1" "6.55" "150.80" "18" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00709" "159" "ENSG00000035687" "ADSS2" "B1AQM5; hsa:159; P30520; Q96EG7" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.997" "0.994" "0.957" "1.005" "0.919" "0.972" "0.997" "0.970" "0.751" "3272.8" "3262.3" "3253.3" "3131.8" "3290.7" "3007.8" "3182.8" "3262.3" "3175.4" "2459.1" "" "" "" "" "" "" "" "" "" "" "2942.6" "2639.7" "2942.7" "3057.1" "2715.6" "3007.8" "2383.2" "2881.5" "2841.3" "877.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5172052490398288729" "False" "High" "IsMasterProtein" "Q9H9S4" "Calcium-binding protein 39-like OS=Homo sapiens OX=9606 GN=CAB39L PE=1 SV=3" "0.000" "False" "100.938" "55" "21" "51" "17" "337" "39.1" "8.40" "169.62" "21" "signal transduction" "cytosol;other cell component" "enzyme regulator activity" "Pf08569" "81617" "ENSG00000102547" "CAB39L" "hsa:81617; Q5TAW6; Q6WG71; Q96FG1; Q9BZ33; Q9H9S4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Energy dependent regulation of mTOR by LKB1-AMPK" "2" "4" "1.035" "0.979" "1.015" "1.060" "0.911" "1.013" "1.057" "0.954" "0.786" "5011.9" "5186.9" "4905.3" "5088.4" "5310.3" "4565.2" "5077.1" "5298.4" "4782.2" "3940.4" "" "" "" "" "" "" "" "" "" "" "4506.2" "4197.1" "4437.0" "4967.0" "4382.2" "4565.2" "3801.6" "4679.9" "4279.1" "1406.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1037069693652576559" "False" "High" "IsMasterProtein" "P31943" "Heterogeneous nuclear ribonucleoprotein H OS=Homo sapiens OX=9606 GN=HNRNPH1 PE=1 SV=4" "0.000" "False" "100.926" "39" "12" "51" "9" "449" "49.2" "6.30" "207.71" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08080" "3187" "ENSG00000169045; ENSG00000284254" "HNRNPH1" "B3KW86; D3DWQ2; P31943; Q6IBM4" "MECP2 and associated Rett syndrome; mRNA processing; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA" "6" "3" "0.963" "0.953" "1.019" "0.954" "0.935" "1.011" "0.935" "0.917" "2.502" "3710.2" "3571.1" "3534.6" "3779.7" "3541.2" "3467.9" "3750.9" "3469.1" "3400.7" "9282.5" "" "" "" "" "" "" "" "" "" "" "3335.8" "2889.6" "3197.1" "3689.5" "2922.3" "3467.9" "2808.6" "3064.2" "3042.9" "3313.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "715968340642640214" "False" "High" "IsMasterProtein" "Q9H9A6" "Leucine-rich repeat-containing protein 40 OS=Homo sapiens OX=9606 GN=LRRC40 PE=1 SV=1" "0.000" "False" "100.869" "48" "25" "34" "25" "602" "68.2" "6.43" "133.63" "25" "signal transduction" "" "" "Pf00560, Pf13855" "55631" "ENSG00000066557" "LRRC40" "hsa:55631; Q9BTR7; Q9H9A6; Q9NSK1; Q9NXC1" "" "" "0" "0" "1.004" "1.022" "0.959" "1.022" "1.016" "1.028" "1.000" "1.061" "1.444" "2045.5" "2053.5" "2090.8" "1961.5" "2089.9" "2079.2" "2102.6" "2046.2" "2171.1" "2953.9" "" "" "" "" "" "" "" "" "" "" "1839.1" "1661.6" "1891.2" "1914.7" "1724.6" "2079.2" "1574.4" "1807.3" "1942.6" "1054.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "306109377846906281" "False" "High" "IsMasterProtein" "P49247" "Ribose-5-phosphate isomerase OS=Homo sapiens OX=9606 GN=RPIA PE=1 SV=3" "0.000" "False" "100.763" "60" "15" "41" "15" "311" "33.2" "8.54" "157.94" "15" "other metabolic processes" "cytosol" "other molecular function" "Pf06026" "22934" "ENSG00000153574" "RPIA" "hsa:22934; P49247; Q541P9; Q96BJ6" "Pentose phosphate metabolism; Metabolic reprogramming in colon cancer; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway; RPIA deficiency: failed conversion of R5P to RU5P; RPIA deficiency: failed conversion of RU5P to R5P" "6" "0" "1.061" "1.079" "1.118" "1.147" "1.035" "1.077" "1.018" "1.101" "0.843" "2680.9" "2843.9" "2891.6" "2996.9" "3075.2" "2773.7" "2887.6" "2728.1" "2952.5" "2258.8" "" "" "" "" "" "" "" "" "" "" "2410.4" "2301.2" "2615.5" "2925.3" "2537.7" "2773.7" "2162.2" "2409.6" "2641.8" "806.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8752239950939414056" "False" "High" "IsMasterProtein" "P18754" "Regulator of chromosome condensation OS=Homo sapiens OX=9606 GN=RCC1 PE=1 SV=1" "0.000" "False" "100.531" "46" "11" "31" "11" "421" "44.9" "7.52" "147.47" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415" "1104" "ENSG00000180198" "RCC1" "hsa:1104; P18754; Q16269; Q6NT97" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation" "4" "0" "0.998" "0.788" "0.981" "0.943" "0.780" "0.969" "0.920" "0.802" "1.198" "2893.2" "2888.4" "2280.3" "2837.9" "2727.2" "2256.2" "2802.2" "2660.9" "2319.3" "3466.2" "" "" "" "" "" "" "" "" "" "" "2601.3" "2337.2" "2062.6" "2770.2" "2250.5" "2256.2" "2098.2" "2350.3" "2075.3" "1237.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6612546022737726869" "False" "High" "IsMasterProtein" "P80303" "Nucleobindin-2 OS=Homo sapiens OX=9606 GN=NUCB2 PE=1 SV=3" "0.000" "False" "100.523" "52" "18" "35" "18" "420" "50.2" "5.12" "127.00" "18" "signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13499" "4925" "ENSG00000070081" "NUCB2" "A8K642; D3DQX5; hsa:4925; P80303; Q8NFT5; V9HW75" "" "" "0" "0" "0.934" "0.985" "0.927" "0.969" "1.062" "0.977" "1.010" "1.056" "0.736" "3336.3" "3115.0" "3287.0" "3092.2" "3232.6" "3541.7" "3259.2" "3370.0" "3524.6" "2455.3" "" "" "" "" "" "" "" "" "" "" "2999.6" "2520.6" "2973.2" "3018.4" "2667.6" "3541.7" "2440.4" "2976.6" "3153.8" "876.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5118939103406682552" "False" "High" "IsMasterProtein" "Q8TEX9" "Importin-4 OS=Homo sapiens OX=9606 GN=IPO4 PE=1 SV=2" "0.000" "False" "100.508" "25" "23" "35" "23" "1081" "118.6" "4.96" "132.32" "23" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03810, Pf13513" "79711" "ENSG00000196497; ENSG00000285248" "IPO4" "B2RN95; hsa:79711; Q2NL96; Q86TZ9; Q8NCG8; Q8TEX9; Q96SJ3; Q9BTI4; Q9H5L0" "" "" "0" "0" "1.095" "0.986" "0.953" "1.087" "0.972" "1.057" "1.031" "0.966" "1.423" "2162.2" "2367.8" "2131.7" "2059.8" "2349.6" "2102.7" "2286.3" "2229.9" "2087.8" "3077.1" "" "" "" "" "" "" "" "" "" "" "1944.0" "1915.9" "1928.2" "2010.7" "1938.9" "2102.7" "1712.0" "1969.6" "1868.2" "1098.4" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7656229856008546485" "False" "High" "IsMasterProtein" "O95453" "Poly(A)-specific ribonuclease PARN OS=Homo sapiens OX=9606 GN=PARN PE=1 SV=1" "0.000" "False" "100.491" "35" "22" "42" "22" "639" "73.4" "6.20" "144.63" "22" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857, Pf08675" "5073" "ENSG00000140694; ENSG00000274829" "PARN" "B2RCB3; B4DDG8; B4DSB0; B4DWR4; B4E1H6; hsa:5073; O95453" "Lung fibrosis" "Deadenylation of mRNA; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA" "4" "0" "1.011" "0.968" "0.979" "1.024" "0.918" "0.973" "1.006" "0.966" "1.046" "4387.0" "4436.6" "4248.0" "4296.1" "4493.5" "4026.3" "4268.3" "4413.1" "4238.3" "4587.7" "" "" "" "" "" "" "" "" "" "" "3944.4" "3589.9" "3842.5" "4193.6" "3708.1" "4026.3" "3196.0" "3897.9" "3792.4" "1637.7" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2629792950046784631" "False" "High" "IsMasterProtein" "Q12849" "G-rich sequence factor 1 OS=Homo sapiens OX=9606 GN=GRSF1 PE=1 SV=3" "0.000" "False" "100.472" "39" "14" "35" "14" "480" "53.1" "6.19" "150.35" "14" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "2926" "ENSG00000132463" "GRSF1" "B3KPW0; hsa:2926; Q12849; Q4W5S5; Q6ZST3; Q8IWD6; Q8NBD2" "VEGFA-VEGFR2 signaling" "Viral mRNA Translation; Mitochondrial RNA degradation" "3" "0" "0.967" "0.882" "0.984" "0.976" "0.869" "0.941" "1.018" "0.892" "1.253" "2467.3" "2384.9" "2175.0" "2426.6" "2408.2" "2144.2" "2321.6" "2510.8" "2201.7" "3090.3" "" "" "" "" "" "" "" "" "" "" "2218.3" "1929.8" "1967.4" "2368.7" "1987.3" "2144.2" "1738.4" "2217.7" "1970.0" "1103.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4191413839330820481" "False" "High" "IsMasterProtein" "O14979" "Heterogeneous nuclear ribonucleoprotein D-like OS=Homo sapiens OX=9606 GN=HNRNPDL PE=1 SV=3" "0.000" "False" "100.425" "32" "13" "64" "11" "420" "46.4" "9.57" "235.85" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "9987" "ENSG00000152795" "HNRNPDL" "hsa:9987; O14979; Q6SPF2; Q7KZ74; Q7KZ75; Q96IM0; Q96S43" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.927" "0.872" "0.973" "0.988" "0.890" "0.943" "1.049" "0.919" "0.774" "6500.6" "6028.9" "5667.5" "6327.8" "6424.5" "5788.6" "6128.8" "6818.8" "5972.8" "5031.5" "" "" "" "" "" "" "" "" "" "" "5844.7" "4878.4" "5126.5" "6176.8" "5301.6" "5788.6" "4589.1" "6022.8" "5344.4" "1796.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870726190365747871" "False" "High" "IsMasterProtein" "P61160" "Actin-related protein 2 OS=Homo sapiens OX=9606 GN=ACTR2 PE=1 SV=1" "0.000" "False" "100.371" "43" "14" "56" "14" "394" "44.7" "6.74" "210.90" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "10097" "ENSG00000138071" "ACTR2" "B2RCP5; D6W5F4; E9PF41; hsa:10097; O15142; P61160; Q96C82" "Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways" "Clathrin-mediated endocytosis; Neutrophil degranulation; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "8" "0" "1.005" "1.011" "0.986" "1.010" "0.956" "0.981" "0.993" "1.004" "0.833" "3737.3" "3756.9" "3779.5" "3683.2" "3774.7" "3572.6" "3666.6" "3709.5" "3752.4" "3112.9" "" "" "" "" "" "" "" "" "" "" "3360.2" "3039.9" "3418.7" "3595.3" "3114.9" "3572.6" "2745.4" "3276.5" "3357.6" "1111.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716870644817082742" "False" "High" "IsMasterProtein" "Q15751" "Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens OX=9606 GN=HERC1 PE=1 SV=2" "0.000" "False" "100.299" "7" "30" "33" "30" "4861" "531.9" "6.04" "103.01" "30" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf00415, Pf00622, Pf00632" "8925" "ENSG00000103657" "HERC1" "hsa:8925; Q15751; Q8IW65" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.074" "0.978" "0.964" "1.038" "1.006" "1.071" "0.969" "1.041" "1.049" "1133.8" "1218.0" "1109.3" "1093.3" "1177.0" "1140.3" "1214.4" "1098.4" "1180.0" "1188.9" "" "" "" "" "" "" "" "" "" "" "1019.4" "985.6" "1003.4" "1067.2" "971.2" "1140.3" "909.3" "970.2" "1055.9" "424.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "114843226561293462" "False" "High" "IsMasterProtein" "P67936" "Tropomyosin alpha-4 chain OS=Homo sapiens OX=9606 GN=TPM4 PE=1 SV=3" "0.000" "False" "100.277" "65" "20" "67" "9" "248" "28.5" "4.69" "210.75" "20" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00261" "7171" "ENSG00000167460" "TPM4" "hsa:7171; P07226; P67936; Q15659; Q5U0D9; Q9BU85; Q9H8Q3; Q9UCS1; Q9UCS2; Q9UCS3; Q9UCS4" "Striated muscle contraction pathway" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "5" "9" "0.932" "0.930" "0.945" "0.918" "0.958" "0.936" "0.993" "0.883" "0.773" "7298.8" "6800.8" "6784.4" "6894.3" "6702.1" "6991.9" "6828.7" "7249.5" "6447.3" "5638.5" "" "" "" "" "" "" "" "" "" "" "6562.3" "5503.0" "6136.7" "6729.8" "5530.7" "6991.9" "5113.2" "6403.2" "5769.0" "2012.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705238959085991770" "False" "High" "IsMasterProtein" "P08865" "Small ribosomal subunit protein uS2 OS=Homo sapiens OX=9606 GN=RPSA PE=1 SV=4" "0.000" "False" "100.031" "53" "15" "44" "15" "295" "32.8" "4.87" "180.74" "15" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;nucleus;other cell component" "translation activity;other molecular function" "Pf00318, Pf16122" "3921" "ENSG00000168028" "RPSA" "hsa:3921; P08865; P11085; P12030; Q16471; Q6IPD1; Q6IPD2; Q6NSD1; Q6NXQ8; Q86VC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.053" "1.073" "1.019" "1.151" "1.162" "1.049" "1.101" "1.125" "0.981" "3204.4" "3373.5" "3437.6" "3265.3" "3686.9" "3724.3" "3360.9" "3529.4" "3603.7" "3142.8" "" "" "" "" "" "" "" "" "" "" "2881.1" "2729.7" "3109.4" "3187.4" "3042.5" "3724.3" "2516.5" "3117.4" "3224.6" "1121.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8112712839841425381" "False" "High" "IsMasterProtein" "Q8TAQ2" "SWI/SNF complex subunit SMARCC2 OS=Homo sapiens OX=9606 GN=SMARCC2 PE=1 SV=1" "0.000" "False" "99.980" "22" "23" "30" "18" "1214" "132.8" "5.69" "120.10" "23" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6601" "ENSG00000139613" "SMARCC2" "F8VTJ5; hsa:6601; Q59GV3; Q8TAQ2; Q92923; Q96E12; Q96GY4" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "5" "0.943" "0.962" "0.988" "0.913" "0.925" "1.051" "0.807" "0.848" "3.841" "2157.8" "2035.3" "2076.1" "2132.3" "1970.3" "1996.3" "2268.4" "1741.9" "1830.4" "8288.4" "" "" "" "" "" "" "" "" "" "" "1940.1" "1646.9" "1877.9" "2081.5" "1625.9" "1996.3" "1698.5" "1538.6" "1637.8" "2958.7" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314781854584049203" "False" "High" "IsMasterProtein" "O75436" "Vacuolar protein sorting-associated protein 26A OS=Homo sapiens OX=9606 GN=VPS26A PE=1 SV=2" "0.000" "False" "99.951" "56" "15" "34" "13" "327" "38.1" "6.57" "122.14" "15" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "9559" "ENSG00000122958" "VPS26A" "A8MZ56; B2RDD3; hsa:9559; O75436; Q8TBH4; Q9H982" "" "WNT ligand biogenesis and trafficking" "1" "2" "1.044" "1.031" "0.963" "1.036" "0.953" "1.022" "0.952" "1.001" "0.771" "2952.2" "3081.3" "3044.6" "2842.5" "3058.4" "2812.8" "3018.1" "2810.4" "2954.6" "2276.8" "" "" "" "" "" "" "" "" "" "" "2654.3" "2493.3" "2754.0" "2774.7" "2523.9" "2812.8" "2259.9" "2482.3" "2643.8" "812.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6687870354662644574" "False" "High" "IsMasterProtein" "Q8N3D4" "EH domain-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=EHBP1L1 PE=1 SV=2" "0.000" "False" "99.766" "23" "24" "31" "24" "1523" "161.8" "4.83" "126.31" "24" "" "other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "254102" "ENSG00000173442" "EHBP1L1" "hsa:254102; Q8N3D4; Q8TB89; Q9H7M7" "" "" "0" "0" "0.984" "1.049" "0.970" "1.018" "1.030" "1.040" "0.967" "1.005" "1.303" "1219.3" "1199.2" "1279.5" "1183.3" "1241.4" "1256.2" "1268.6" "1178.7" "1225.3" "1588.9" "" "" "" "" "" "" "" "" "" "" "1096.2" "970.4" "1157.3" "1155.0" "1024.5" "1256.2" "949.9" "1041.1" "1096.4" "567.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4243643898250283401" "False" "High" "IsMasterProtein" "Q9UI08" "Ena/VASP-like protein OS=Homo sapiens OX=9606 GN=EVL PE=1 SV=2" "0.000" "False" "99.722" "46" "17" "38" "16" "416" "44.6" "8.84" "145.00" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "51466" "ENSG00000196405" "EVL" "A8K105; B7Z3I5; hsa:51466; O95884; Q7Z522; Q8TBV1; Q9UF25; Q9UI08; Q9UIC2" "" "RHO GTPases Activate Formins; Generation of second messenger molecules; Signaling by ROBO receptors" "3" "1" "1.016" "0.967" "1.088" "1.029" "1.054" "1.023" "1.033" "1.032" "1.068" "3607.1" "3663.4" "3487.4" "3923.4" "3713.4" "3801.3" "3691.2" "3725.8" "3723.7" "3853.1" "" "" "" "" "" "" "" "" "" "" "3243.2" "2964.3" "3154.5" "3829.8" "3064.4" "3801.3" "2763.9" "3290.9" "3332.0" "1375.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3579121838691215902" "False" "High" "IsMasterProtein" "Q7Z6I6" "Rho GTPase-activating protein 30 OS=Homo sapiens OX=9606 GN=ARHGAP30 PE=1 SV=3" "0.000" "False" "99.671" "22" "21" "30" "21" "1101" "118.5" "4.81" "119.46" "21" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00620" "257106" "ENSG00000186517" "ARHGAP30" "hsa:257106; Q5SY52; Q5SY53; Q5SY54; Q6ZML6; Q7Z3J8; Q7Z6I6; Q86XI7" "" "RHOU GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOA GTPase cycle" "4" "0" "0.981" "0.993" "1.019" "1.039" "1.006" "1.103" "1.042" "0.988" "1.075" "2656.6" "2605.1" "2637.4" "2708.2" "2759.5" "2672.0" "2931.5" "2768.7" "2623.8" "2857.1" "" "" "" "" "" "" "" "" "" "" "2388.6" "2107.9" "2385.6" "2643.6" "2277.2" "2672.0" "2195.0" "2445.5" "2347.8" "1019.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909350322516910922" "False" "High" "IsMasterProtein" "P40222" "Alpha-taxilin OS=Homo sapiens OX=9606 GN=TXLNA PE=1 SV=3" "0.000" "False" "99.657" "36" "20" "43" "19" "546" "61.9" "6.52" "156.18" "20" "transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf09728" "200081" "ENSG00000084652" "TXLNA" "D3DPP6; hsa:200081; P40222; Q5TFJ6; Q66K62; Q86T54; Q86T85; Q86T86; Q86Y86; Q86YW3; Q8N2Y3" "" "Other interleukin signaling" "1" "1" "0.933" "0.996" "0.941" "1.000" "1.008" "0.939" "1.027" "1.034" "0.821" "3517.3" "3282.4" "3503.6" "3311.1" "3518.9" "3544.9" "3302.4" "3612.0" "3638.0" "2887.2" "" "" "" "" "" "" "" "" "" "" "3162.4" "2656.0" "3169.1" "3232.1" "2903.8" "3544.9" "2472.8" "3190.4" "3255.2" "1030.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8716615983158352243" "False" "High" "IsMasterProtein" "P27695" "DNA repair nuclease/redox regulator APEX1 OS=Homo sapiens OX=9606 GN=APEX1 PE=1 SV=2" "0.000" "False" "99.383" "56" "14" "43" "14" "318" "35.5" "8.12" "186.83" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372" "328" "ENSG00000100823; ENSG00000291796" "APEX1" "hsa:328; P27695; Q969L5; Q99775" "Thyroid stimulating hormone (TSH) signaling pathway; Spinal cord injury; Base excision repair; DNA repair pathways, full network" "Displacement of DNA glycosylase by APEX1; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Abasic sugar-phosphate removal via the single-nucleotide replacement pathway" "10" "0" "1.021" "0.902" "1.103" "0.933" "1.003" "1.000" "1.023" "0.884" "1.047" "5906.2" "6031.0" "5327.6" "6515.1" "5508.7" "5922.2" "5908.8" "6039.7" "5222.7" "6181.8" "" "" "" "" "" "" "" "" "" "" "5310.3" "4880.0" "4819.0" "6359.6" "4545.9" "5922.2" "4424.3" "5334.7" "4673.2" "2206.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2229585917492551052" "False" "High" "IsMasterProtein" "P53992" "Protein transport protein Sec24C OS=Homo sapiens OX=9606 GN=SEC24C PE=1 SV=3" "0.000" "False" "99.344" "24" "25" "39" "24" "1094" "118.2" "7.06" "143.20" "25" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9632" "ENSG00000176986" "SEC24C" "B4DZT4; hsa:9632; P53992; Q8WV25" "Sterol regulatory element-binding proteins (SREBP) signaling" "COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "1" "1.017" "1.035" "0.958" "1.031" "0.994" "0.979" "0.976" "1.030" "0.918" "3895.1" "3960.1" "4032.2" "3729.9" "4015.2" "3870.6" "3812.6" "3803.1" "4010.9" "3577.4" "" "" "" "" "" "" "" "" "" "" "3502.0" "3204.3" "3647.3" "3640.9" "3313.4" "3870.6" "2854.8" "3359.2" "3588.9" "1277.0" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4801012359298608333" "False" "High" "IsMasterProtein" "Q6L8Q7" "2',5'-phosphodiesterase 12 OS=Homo sapiens OX=9606 GN=PDE12 PE=1 SV=2" "0.000" "False" "99.227" "42" "19" "33" "19" "609" "67.3" "6.57" "122.55" "19" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf03372, Pf21171" "201626" "ENSG00000174840" "PDE12" "B4DTU8; hsa:201626; Q6L8Q7; Q8IYU3; Q8NDU2; Q8TE78" "Phosphodiesterases in neuronal function" "OAS antiviral response" "2" "0" "1.058" "1.055" "0.985" "1.081" "1.072" "1.081" "1.027" "1.071" "0.844" "1172.9" "1240.4" "1237.8" "1155.3" "1268.4" "1257.4" "1267.5" "1204.9" "1255.6" "990.0" "" "" "" "" "" "" "" "" "" "" "1054.5" "1003.7" "1119.7" "1127.7" "1046.7" "1257.4" "949.1" "1064.2" "1123.5" "353.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602347345364685954" "False" "High" "IsMasterProtein" "P09429" "High mobility group protein B1 OS=Homo sapiens OX=9606 GN=HMGB1 PE=1 SV=3" "0.000" "False" "99.207" "43" "14" "95" "9" "215" "24.9" "5.74" "327.95" "14" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3146" "ENSG00000189403" "HMGB1" "A5D8W9; hsa:3146; P09429; Q14321; Q5T7C3; Q6IBE1" "Retinoblastoma gene in cancer; VEGFA-VEGFR2 signaling; Suppression of HMGB1-mediated inflammation by THBD; Base excision repair; DNA repair pathways, full network; Pleural mesothelioma; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; DNA damage response (only ATM dependent)" "ER-Phagosome pathway; Neutrophil degranulation; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand; Apoptosis induced DNA fragmentation; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; Pyroptosis; Advanced glycosylation endproduct receptor signaling" "20" "5" "0.879" "0.913" "0.975" "0.902" "0.993" "0.921" "1.002" "0.882" "0.787" "10081.0" "8863.5" "9205.6" "9830.0" "9094.7" "10012.4" "9288.7" "10103.6" "8889.0" "7933.7" "" "" "" "" "" "" "" "" "" "" "9063.8" "7172.1" "8326.8" "9595.4" "7505.1" "10012.4" "6955.1" "8924.1" "7953.8" "2832.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1311899877800093537" "False" "High" "IsMasterProtein" "Q9H0K6" "Pseudouridylate synthase PUS7L OS=Homo sapiens OX=9606 GN=PUS7L PE=1 SV=1" "0.000" "False" "99.173" "42" "27" "37" "27" "701" "80.6" "7.56" "124.71" "27" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01142" "83448" "ENSG00000129317" "PUS7L" "B3KUJ1; hsa:83448; Q05CU0; Q6AHZ3; Q6NUP2; Q9H0K6" "" "" "0" "0" "0.999" "1.013" "0.961" "0.998" "1.015" "0.995" "0.943" "1.035" "1.043" "2730.1" "2727.7" "2766.7" "2622.8" "2724.0" "2771.2" "2717.2" "2573.5" "2825.5" "2847.4" "" "" "" "" "" "" "" "" "" "" "2454.6" "2207.1" "2502.5" "2560.2" "2247.9" "2771.2" "2034.6" "2273.1" "2528.2" "1016.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073830227573610312" "False" "High" "IsMasterProtein" "Q9NR45" "Sialic acid synthase OS=Homo sapiens OX=9606 GN=NANS PE=1 SV=2" "0.000" "False" "99.158" "44" "14" "44" "14" "359" "40.3" "6.74" "177.39" "14" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf03102, Pf08666" "54187" "ENSG00000095380" "NANS" "B2RE98; Q8WUV9; Q9BWS6; Q9NR45; Q9NVD4" "Sialylation" "Sialic acid metabolism" "2" "0" "1.026" "1.010" "1.030" "1.032" "1.033" "0.986" "1.029" "1.040" "0.811" "3557.5" "3649.9" "3592.4" "3664.7" "3671.8" "3674.6" "3508.5" "3661.2" "3701.1" "2886.1" "" "" "" "" "" "" "" "" "" "" "3198.6" "2953.3" "3249.5" "3577.3" "3030.0" "3674.6" "2627.1" "3233.8" "3311.7" "1030.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6826541305752528518" "False" "High" "IsMasterProtein" "P23381" "Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens OX=9606 GN=WARS1 PE=1 SV=2" "0.000" "False" "99.121" "33" "13" "35" "13" "471" "53.1" "6.23" "143.46" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00458, Pf00579" "7453" "ENSG00000140105" "WARS1" "A6NGN1; A6NID3; hsa:7453; P23381; P78535; Q502Y0; Q53XB6; Q9UDI5; Q9UDL3" "Photodynamic therapy-induced unfolded protein response; Amino acid metabolism" "Cytosolic tRNA aminoacylation" "3" "0" "0.968" "1.011" "1.008" "0.980" "1.007" "0.963" "0.978" "1.032" "0.814" "4524.5" "4379.1" "4575.9" "4558.9" "4435.8" "4557.0" "4357.4" "4425.2" "4667.5" "3681.1" "" "" "" "" "" "" "" "" "" "" "4068.0" "3543.4" "4139.1" "4450.1" "3660.5" "4557.0" "3262.7" "3908.6" "4176.4" "1314.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220209801310809840" "False" "High" "IsMasterProtein" "P60891" "Ribose-phosphate pyrophosphokinase 1 OS=Homo sapiens OX=9606 GN=PRPS1 PE=1 SV=2" "0.000" "False" "98.915" "56" "18" "48" "9" "318" "34.8" "6.98" "199.57" "18" "other metabolic processes;developmental processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5631" "ENSG00000147224" "PRPS1" "B1ALA8; B2R6T7; B4DNL6; D3DUX6; hsa:5631; P09329; P60891" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "8" "1.037" "1.024" "0.935" "0.992" "0.992" "1.023" "0.992" "1.028" "0.799" "3801.7" "3943.3" "3893.6" "3554.8" "3772.1" "3769.7" "3890.5" "3772.2" "3906.7" "3037.6" "" "" "" "" "" "" "" "" "" "" "3418.1" "3190.8" "3521.8" "3470.0" "3112.8" "3769.7" "2913.1" "3331.9" "3495.7" "1084.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3820767575237366491" "False" "High" "IsMasterProtein" "Q9HAU5" "Regulator of nonsense transcripts 2 OS=Homo sapiens OX=9606 GN=UPF2 PE=1 SV=1" "0.000" "False" "98.625" "26" "31" "35" "31" "1272" "147.7" "5.69" "124.93" "31" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02854, Pf04050" "26019" "ENSG00000151461" "UPF2" "A6NLJ5; D3DRS0; hsa:26019; Q14BM1; Q5W0J4; Q8N8U1; Q9H1J2; Q9HAU5; Q9NWL1; Q9P2D9; Q9Y4M9" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "0.962" "1.001" "0.964" "0.967" "0.980" "1.062" "0.972" "0.982" "1.185" "2249.3" "2163.3" "2250.4" "2167.8" "2175.4" "2205.2" "2389.6" "2186.5" "2209.1" "2666.4" "" "" "" "" "" "" "" "" "" "" "2022.3" "1750.4" "2035.6" "2116.1" "1795.1" "2205.2" "1789.3" "1931.3" "1976.7" "951.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7657012177295081485" "False" "High" "IsMasterProtein" "O43684" "Mitotic checkpoint protein BUB3 OS=Homo sapiens OX=9606 GN=BUB3 PE=1 SV=1" "0.000" "False" "98.611" "62" "16" "45" "16" "328" "37.1" "6.84" "186.50" "16" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "9184" "ENSG00000154473" "BUB3" "A6NJ42; B2R6E7; D3DRE9; hsa:9184; O43684; O43685" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "12" "0" "0.996" "1.009" "1.048" "0.987" "1.006" "0.968" "0.952" "0.978" "0.829" "3940.7" "3925.5" "3974.5" "4129.7" "3890.4" "3963.0" "3815.3" "3753.3" "3853.1" "3264.9" "" "" "" "" "" "" "" "" "" "" "3543.1" "3176.4" "3595.1" "4031.1" "3210.5" "3963.0" "2856.8" "3315.2" "3447.7" "1165.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200158126373336546" "False" "High" "IsMasterProtein" "Q6IBS0" "Twinfilin-2 OS=Homo sapiens OX=9606 GN=TWF2 PE=1 SV=2" "0.000" "False" "98.254" "51" "18" "44" "14" "349" "39.5" "6.84" "172.33" "18" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "11344" "ENSG00000247596" "TWF2" "hsa:11344; Q6IBS0; Q9Y3F5" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "4" "0.999" "0.954" "0.952" "0.977" "0.913" "0.976" "0.975" "0.966" "0.812" "5174.9" "5169.8" "4939.4" "4925.4" "5054.7" "4723.0" "5051.4" "5046.0" "4998.1" "4203.1" "" "" "" "" "" "" "" "" "" "" "4652.8" "4183.2" "4467.8" "4807.9" "4171.2" "4723.0" "3782.3" "4456.9" "4472.3" "1500.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051331415144919391" "False" "High" "IsMasterProtein" "P49189" "4-trimethylaminobutyraldehyde dehydrogenase OS=Homo sapiens OX=9606 GN=ALDH9A1 PE=1 SV=3" "0.000" "False" "97.898" "37" "16" "38" "16" "494" "53.8" "5.87" "130.67" "16" "cell organization and biogenesis;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00171" "223" "ENSG00000143149" "ALDH9A1" "B2R6X1; B4DXY7; B9EKV4; hsa:223; P49189; Q5VV90; Q6LCL1; Q9NZT7" "GABA receptor signaling; Fluoroacetic acid toxicity; Opioid receptor pathways" "Carnitine synthesis" "4" "0" "1.025" "1.016" "1.000" "0.994" "0.975" "0.977" "0.983" "1.037" "0.756" "3053.5" "3129.3" "3102.2" "3054.4" "3034.6" "2977.8" "2982.9" "3001.1" "3167.6" "2308.2" "" "" "" "" "" "" "" "" "" "" "2745.4" "2532.1" "2806.0" "2981.5" "2504.2" "2977.8" "2233.5" "2650.7" "2834.3" "823.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-16918109513615625" "False" "High" "IsMasterProtein" "P51149" "Ras-related protein Rab-7a OS=Homo sapiens OX=9606 GN=RAB7A PE=1 SV=1" "0.000" "False" "97.746" "73" "14" "43" "14" "207" "23.5" "6.70" "158.26" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "7879" "ENSG00000075785" "RAB7A" "A8K3V6; hsa:7879; P51149; Q9NWJ0; Q9UPB0" "Ebola virus infection in host; Autosomal recessive osteopetrosis pathways; Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; Prevention of phagosomal-lysosomal fusion; RAB geranylgeranylation; TBC/RABGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAB GEFs exchange GTP for GDP on RABs; MHC class II antigen presentation; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Suppression of autophagy; RHOH GTPase cycle" "20" "0" "0.950" "0.986" "1.021" "1.028" "0.926" "0.927" "0.935" "0.997" "0.716" "3949.3" "3751.1" "3892.9" "4032.5" "4058.4" "3658.2" "3661.1" "3691.2" "3935.8" "2829.4" "" "" "" "" "" "" "" "" "" "" "3550.8" "3035.2" "3521.3" "3936.3" "3349.1" "3658.2" "2741.4" "3260.3" "3521.7" "1010.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656717572997732758" "False" "High" "IsMasterProtein" "P30566" "Adenylosuccinate lyase OS=Homo sapiens OX=9606 GN=ADSL PE=1 SV=2" "0.000" "False" "97.679" "41" "14" "38" "14" "484" "54.9" "7.11" "135.20" "14" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf10397" "158" "ENSG00000239900" "ADSL" "B0QY76; hsa:158; O75495; P30566; Q5TI34" "" "Purine ribonucleoside monophosphate biosynthesis" "1" "0" "0.973" "0.938" "1.015" "0.954" "0.949" "0.943" "0.972" "0.994" "0.755" "2805.1" "2728.0" "2632.4" "2848.1" "2675.7" "2662.6" "2645.8" "2725.9" "2789.4" "2116.7" "" "" "" "" "" "" "" "" "" "" "2522.0" "2207.4" "2381.1" "2780.1" "2208.0" "2662.6" "1981.1" "2407.7" "2495.9" "755.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1088137077242897803" "False" "High" "IsMasterProtein" "P51659" "Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens OX=9606 GN=HSD17B4 PE=1 SV=3" "0.000" "False" "97.651" "37" "21" "33" "21" "736" "79.6" "8.84" "128.54" "21" "other metabolic processes;developmental processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf01575, Pf02036" "3295" "ENSG00000133835" "HSD17B4" "B4DNV1; B4DVS5; E9PB82; F5HE57; hsa:3295; P51659" "Androgen receptor network in prostate cancer; Steroid biosynthesis; Disorders of bile acid synthesis and biliary transport; Primary ovarian insufficiency" "TYSND1 cleaves peroxisomal proteins; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "10" "0" "1.088" "1.131" "1.009" "1.106" "1.080" "1.057" "1.048" "1.131" "0.829" "2602.4" "2831.5" "2942.5" "2627.0" "2878.2" "2809.4" "2751.8" "2728.5" "2944.3" "2156.3" "" "" "" "" "" "" "" "" "" "" "2339.8" "2291.2" "2661.6" "2564.3" "2375.1" "2809.4" "2060.5" "2410.0" "2634.5" "769.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1585168671336988915" "False" "High" "IsMasterProtein" "Q01433" "AMP deaminase 2 OS=Homo sapiens OX=9606 GN=AMPD2 PE=1 SV=3" "0.000" "False" "97.646" "32" "25" "38" "24" "825" "94.8" "6.55" "130.65" "25" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf19326" "271" "ENSG00000116337" "AMPD2" "A0A5F9UK94; B4DK50; B4DZI5; E9PNG0; hsa:271; Q01433; Q14856; Q14857; Q16686; Q16687; Q16688; Q16729; Q5T693; Q5T695; Q96IA1; Q9UDX8; Q9UDX9; Q9UMU4" "" "Purine salvage" "1" "1" "1.002" "1.001" "0.981" "1.020" "0.965" "1.010" "0.992" "0.992" "0.833" "3379.3" "3386.6" "3381.7" "3314.7" "3447.1" "3260.4" "3411.6" "3352.7" "3350.9" "2816.5" "" "" "" "" "" "" "" "" "" "" "3038.3" "2740.3" "3058.8" "3235.6" "2844.6" "3260.4" "2554.5" "2961.3" "2998.4" "1005.4" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6317068778034787864" "False" "High" "IsMasterProtein" "Q9BTE3" "Mini-chromosome maintenance complex-binding protein OS=Homo sapiens OX=9606 GN=MCMBP PE=1 SV=2" "0.000" "False" "97.613" "37" "20" "37" "20" "642" "72.9" "5.87" "133.53" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09739" "79892" "ENSG00000197771" "MCMBP" "B3KSP7; hsa:79892; Q6IA56; Q9BTE3; Q9BVT9; Q9H916" "" "" "0" "0" "1.051" "1.148" "0.993" "1.055" "1.159" "1.020" "1.037" "1.132" "1.270" "3247.0" "3411.6" "3727.8" "3225.6" "3425.2" "3763.2" "3312.7" "3365.9" "3676.7" "4123.6" "" "" "" "" "" "" "" "" "" "" "2919.4" "2760.5" "3371.9" "3148.7" "2826.5" "3763.2" "2480.4" "2973.0" "3289.9" "1472.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7662049170687489427" "False" "High" "IsMasterProtein" "Q9Y376" "Calcium-binding protein 39 OS=Homo sapiens OX=9606 GN=CAB39 PE=1 SV=1" "0.000" "False" "97.574" "55" "20" "52" "16" "341" "39.8" "6.89" "174.34" "20" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf08569" "51719" "ENSG00000135932" "CAB39" "A8K8L7; hsa:51719; Q9Y376" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias" "Neutrophil degranulation; Energy dependent regulation of mTOR by LKB1-AMPK" "6" "0" "0.987" "0.983" "0.992" "0.979" "0.940" "1.024" "1.028" "0.983" "0.759" "5132.9" "5064.7" "5044.3" "5091.7" "5026.2" "4823.1" "5258.0" "5278.5" "5045.4" "3895.7" "" "" "" "" "" "" "" "" "" "" "4615.0" "4098.2" "4562.8" "4970.2" "4147.8" "4823.1" "3937.0" "4662.3" "4514.6" "1390.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2179215368678635356" "False" "High" "IsMasterProtein" "Q8IYB8" "ATP-dependent RNA helicase SUPV3L1, mitochondrial OS=Homo sapiens OX=9606 GN=SUPV3L1 PE=1 SV=1" "0.000" "False" "97.556" "28" "19" "32" "19" "786" "87.9" "7.99" "125.81" "19" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00271, Pf12513, Pf18114, Pf18147" "6832" "ENSG00000156502" "SUPV3L1" "A8K301; hsa:6832; O43630; Q8IYB8" "" "Mitochondrial RNA degradation" "1" "0" "1.008" "1.020" "0.975" "1.009" "0.979" "1.003" "1.009" "1.011" "0.857" "2661.7" "2683.2" "2715.5" "2594.2" "2684.5" "2606.5" "2669.4" "2684.5" "2690.0" "2281.9" "" "" "" "" "" "" "" "" "" "" "2393.2" "2171.1" "2456.3" "2532.3" "2215.3" "2606.5" "1998.8" "2371.2" "2407.0" "814.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "854871700707894946" "False" "High" "IsMasterProtein" "Q9NZL4" "Hsp70-binding protein 1 OS=Homo sapiens OX=9606 GN=HSPBP1 PE=1 SV=2" "0.000" "False" "97.534" "55" "15" "36" "15" "359" "39.3" "5.21" "149.38" "15" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf08609" "23640" "ENSG00000133265" "HSPBP1" "B3KQP0; B4DG11; hsa:23640; O95351; Q6ZNU5; Q9NZL4" "" "" "0" "0" "1.064" "1.044" "1.018" "1.116" "1.083" "1.137" "1.087" "1.068" "1.279" "2329.6" "2478.0" "2433.2" "2370.4" "2599.1" "2522.0" "2648.3" "2533.2" "2487.1" "2979.3" "" "" "" "" "" "" "" "" "" "" "2094.5" "2005.2" "2200.9" "2313.8" "2144.8" "2522.0" "1983.0" "2237.5" "2225.5" "1063.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819248738273411506" "False" "High" "IsMasterProtein" "O14981" "TATA-binding protein-associated factor 172 OS=Homo sapiens OX=9606 GN=BTAF1 PE=1 SV=2" "0.000" "False" "97.377" "15" "24" "29" "24" "1849" "206.8" "6.52" "100.22" "24" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf12054" "9044" "ENSG00000095564" "BTAF1" "B4E0W6; hsa:9044; O14981; O43578" "" "" "0" "0" "1.000" "1.007" "0.970" "1.040" "0.989" "0.999" "0.996" "0.989" "1.127" "2021.4" "2020.7" "2035.3" "1959.9" "2102.3" "1999.5" "2020.0" "2013.6" "1998.9" "2279.0" "" "" "" "" "" "" "" "" "" "" "1817.5" "1635.1" "1841.0" "1913.1" "1734.9" "1999.5" "1512.5" "1778.5" "1788.6" "813.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1217217274349295091" "False" "High" "IsMasterProtein" "Q9Y4E8" "Ubiquitin carboxyl-terminal hydrolase 15 OS=Homo sapiens OX=9606 GN=USP15 PE=1 SV=3" "0.000" "False" "97.255" "28" "24" "33" "23" "981" "112.3" "5.22" "120.42" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "9958" "ENSG00000135655" "USP15" "hsa:9958; Q08AL5; Q9H8G9; Q9HCA6; Q9UNP0; Q9Y4E8; Q9Y5B5" "" "UCH proteinases; Ub-specific processing proteases; Downregulation of TGF-beta receptor signaling" "3" "0" "0.979" "0.941" "0.948" "0.987" "0.938" "0.965" "0.958" "0.962" "0.977" "3434.6" "3360.9" "3230.5" "3256.4" "3389.5" "3220.3" "3313.0" "3288.9" "3305.5" "3357.1" "" "" "" "" "" "" "" "" "" "" "3088.0" "2719.5" "2922.1" "3178.7" "2797.0" "3220.3" "2480.7" "2905.0" "2957.7" "1198.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4220399671961536759" "False" "High" "IsMasterProtein" "Q92918" "Mitogen-activated protein kinase kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP4K1 PE=1 SV=1" "0.000" "False" "97.201" "30" "21" "35" "21" "833" "91.2" "8.34" "130.98" "21" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "11184" "ENSG00000104814" "MAP4K1" "hsa:11184; Q92918" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Cardiac hypertrophic response; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; T-cell receptor signaling pathway" "" "14" "0" "1.006" "0.946" "0.956" "0.987" "0.934" "0.978" "0.967" "1.004" "1.161" "2939.4" "2956.8" "2781.2" "2809.2" "2901.5" "2744.1" "2874.0" "2842.9" "2950.5" "3411.4" "" "" "" "" "" "" "" "" "" "" "2642.8" "2392.5" "2515.7" "2742.2" "2394.4" "2744.1" "2152.0" "2511.0" "2640.1" "1217.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4186316132273188222" "False" "High" "IsMasterProtein" "Q92538" "Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=GBF1 PE=1 SV=3" "0.000" "False" "97.087" "17" "27" "33" "27" "1860" "206.4" "5.73" "107.39" "27" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf12783" "8729" "ENSG00000107862" "GBF1" "A0A7P0RGV0; hsa:8729; Q149P0; Q149P1; Q5VXX3; Q92538; Q96CK6; Q96HZ3; Q9H473" "" "VxPx cargo-targeting to cilium; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; trans-Golgi Network Vesicle Budding" "4" "0" "1.034" "1.039" "0.985" "0.995" "1.011" "0.986" "0.973" "0.997" "1.439" "1878.7" "1943.4" "1951.5" "1849.9" "1868.6" "1898.7" "1851.8" "1827.4" "1873.2" "2703.6" "" "" "" "" "" "" "" "" "" "" "1689.1" "1572.5" "1765.2" "1805.7" "1542.0" "1898.7" "1386.6" "1614.1" "1676.1" "965.1" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7890686096526149286" "False" "High" "IsMasterProtein" "Q13347" "Eukaryotic translation initiation factor 3 subunit I OS=Homo sapiens OX=9606 GN=EIF3I PE=1 SV=1" "0.000" "False" "97.076" "67" "16" "46" "16" "325" "36.5" "5.64" "167.34" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00400, Pf12894" "8668" "ENSG00000084623" "EIF3I" "hsa:8668; Q13347" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.040" "1.069" "1.027" "1.026" "1.054" "1.059" "1.009" "1.079" "1.581" "3784.6" "3937.5" "4046.2" "3885.4" "3884.2" "3990.2" "4009.1" "3817.8" "4081.9" "5983.2" "" "" "" "" "" "" "" "" "" "" "3402.8" "3186.1" "3660.0" "3792.7" "3205.3" "3990.2" "3001.9" "3372.1" "3652.4" "2135.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209519133895389976" "False" "High" "IsMasterProtein" "Q9P107" "GEM-interacting protein OS=Homo sapiens OX=9606 GN=GMIP PE=1 SV=2" "0.000" "False" "96.772" "28" "21" "28" "21" "970" "106.6" "5.72" "106.09" "21" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00620" "51291" "ENSG00000089639" "GMIP" "A0AVN9; B7ZLZ0; hsa:51291; Q9P107" "" "RHOA GTPase cycle; RAC1 GTPase cycle; CDC42 GTPase cycle" "3" "0" "1.055" "1.007" "0.971" "1.018" "1.037" "1.034" "1.008" "1.023" "1.516" "2655.2" "2800.7" "2674.3" "2577.1" "2703.6" "2752.3" "2745.2" "2676.5" "2715.8" "4026.3" "" "" "" "" "" "" "" "" "" "" "2387.3" "2266.2" "2419.0" "2515.6" "2231.0" "2752.3" "2055.5" "2364.1" "2430.1" "1437.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1108045160068185156" "False" "High" "IsMasterProtein" "P20073" "Annexin A7 OS=Homo sapiens OX=9606 GN=ANXA7 PE=1 SV=3" "0.000" "False" "96.750" "37" "17" "50" "17" "488" "52.7" "5.68" "164.17" "17" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00191" "310" "ENSG00000138279" "ANXA7" "hsa:310; P20073; Q5F2H3; Q5T0M6; Q5T0M7" "" "" "0" "0" "0.996" "1.000" "0.976" "1.042" "1.022" "1.049" "1.022" "1.041" "0.864" "3609.8" "3595.6" "3609.1" "3523.1" "3762.3" "3689.9" "3787.9" "3689.6" "3758.2" "3119.6" "" "" "" "" "" "" "" "" "" "" "3245.6" "2909.4" "3264.6" "3439.1" "3104.7" "3689.9" "2836.3" "3258.9" "3362.8" "1113.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339242402032558616" "False" "High" "IsMasterProtein" "P05091" "Aldehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH2 PE=1 SV=2" "0.000" "False" "96.706" "42" "18" "29" "17" "517" "56.3" "7.05" "124.05" "18" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00171" "217" "ENSG00000111275" "ALDH2" "B4DW54; E7EUE5; hsa:217; P05091; Q03639; Q6IB13; Q6IV71" "Fatty acid omega-oxidation; Ethanol effects on histone modifications; Tryptophan metabolism; Fluoroacetic acid toxicity" "Mitochondrial protein degradation; Smooth Muscle Contraction; Ethanol oxidation; Metabolism of serotonin" "8" "1" "0.977" "0.950" "0.988" "0.984" "0.978" "0.936" "1.006" "0.978" "0.752" "3105.2" "3033.9" "2951.2" "3068.4" "3054.0" "3035.9" "2907.4" "3124.4" "3035.8" "2336.5" "" "" "" "" "" "" "" "" "" "" "2791.9" "2454.9" "2669.5" "2995.1" "2520.2" "3035.9" "2177.0" "2759.7" "2716.4" "834.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9009655612245832545" "False" "High" "IsMasterProtein" "Q9Y4G6" "Talin-2 OS=Homo sapiens OX=9606 GN=TLN2 PE=1 SV=4" "0.000" "False" "96.699" "7" "17" "38" "4" "2542" "271.4" "5.57" "132.53" "17" "cell adhesion;cell organization and biogenesis" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00373, Pf01608, Pf08913, Pf09141, Pf09379, Pf16511, Pf21692" "83660" "ENSG00000171914" "TLN2" "A6NLB8; hsa:83660; Q9Y4G6" "Focal adhesion" "" "1" "1" "1.060" "0.867" "1.017" "0.945" "1.021" "0.961" "1.006" "1.062" "0.877" "495.0" "524.8" "429.1" "503.5" "467.9" "505.3" "475.5" "497.8" "525.8" "434.0" "" "" "" "" "" "" "" "" "" "" "445.0" "424.7" "388.1" "491.5" "386.1" "505.3" "356.0" "439.7" "470.5" "154.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8220013005457955452" "False" "High" "IsMasterProtein" "Q15424" "Scaffold attachment factor B1 OS=Homo sapiens OX=9606 GN=SAFB PE=1 SV=4" "0.000" "False" "96.655" "23" "20" "48" "13" "915" "102.6" "5.47" "151.18" "20" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "6294" "ENSG00000160633" "SAFB" "A0AV56; B7Z5B6; B7ZLP6; F5H0H3; hsa:6294; O60406; Q15424; Q59HH8" "Interleukin-1 (IL-1) structural pathway" "SUMOylation of transcription cofactors" "2" "7" "1.034" "0.919" "0.952" "0.979" "0.967" "0.966" "0.996" "0.885" "1.191" "3870.2" "3999.9" "3557.5" "3683.0" "3789.2" "3742.7" "3740.4" "3853.5" "3423.6" "4610.4" "" "" "" "" "" "" "" "" "" "" "3479.7" "3236.6" "3217.9" "3595.2" "3126.9" "3742.7" "2800.7" "3403.7" "3063.4" "1645.8" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5945011317712517661" "False" "High" "IsMasterProtein" "P25787" "Proteasome subunit alpha type-2 OS=Homo sapiens OX=9606 GN=PSMA2 PE=1 SV=2" "0.000" "False" "96.577" "52" "10" "35" "10" "234" "25.9" "7.43" "184.45" "10" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5683" "ENSG00000106588" "PSMA2" "hsa:5683; P25787; Q6ICS6; Q9BU45" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Downstream TCR signaling; Neutrophil degranulation; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.000" "0.975" "1.113" "1.000" "0.981" "0.995" "0.998" "1.073" "0.846" "2096.3" "2097.0" "2043.3" "2333.2" "2095.4" "2056.1" "2085.9" "2091.9" "2249.0" "1774.0" "" "" "" "" "" "" "" "" "" "" "1884.8" "1696.8" "1848.2" "2277.5" "1729.2" "2056.1" "1561.9" "1847.7" "2012.4" "633.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "51923672491572090" "False" "High" "IsMasterProtein" "Q4J6C6" "Prolyl endopeptidase-like OS=Homo sapiens OX=9606 GN=PREPL PE=1 SV=1" "0.000" "False" "96.366" "34" "20" "31" "19" "727" "83.9" "6.38" "122.73" "20" "protein metabolism;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus" "other molecular function" "Pf00326, Pf02897" "9581" "ENSG00000138078" "PREPL" "A7E2X6; D6W5A3; hsa:9581; O43163; Q4J6C3; Q4J6C4; Q4J6C6; Q4ZG39; Q6ZMW7; Q96DW7" "Primary ovarian insufficiency" "" "1" "0" "1.077" "1.145" "0.933" "1.061" "1.025" "1.016" "0.967" "1.172" "1.008" "2191.5" "2360.1" "2510.2" "2045.1" "2324.2" "2246.6" "2227.5" "2118.4" "2567.8" "2208.4" "" "" "" "" "" "" "" "" "" "" "1970.3" "1909.7" "2270.5" "1996.3" "1918.0" "2246.6" "1667.9" "1871.2" "2297.7" "788.3" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2100681429736934038" "False" "High" "IsMasterProtein" "O95218" "Zinc finger Ran-binding domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZRANB2 PE=1 SV=2" "0.000" "False" "96.328" "42" "17" "41" "17" "330" "37.4" "10.01" "137.63" "17" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00641" "9406" "ENSG00000132485" "ZRANB2" "D3DQ75; hsa:9406; O95218; Q53GS3; Q59F92; Q5VV33; Q5VV34; Q8IXN6; Q9UP63" "" "" "0" "0" "0.968" "1.008" "0.964" "0.985" "1.066" "0.940" "1.015" "1.003" "0.819" "4858.9" "4701.6" "4898.5" "4682.9" "4788.2" "5181.4" "4567.9" "4934.1" "4873.3" "3981.7" "" "" "" "" "" "" "" "" "" "" "4368.6" "3804.3" "4430.9" "4571.2" "3951.3" "5181.4" "3420.4" "4358.1" "4360.6" "1421.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896567990825277729" "False" "High" "IsMasterProtein" "O94925" "Glutaminase kidney isoform, mitochondrial OS=Homo sapiens OX=9606 GN=GLS PE=1 SV=1" "0.000" "False" "96.257" "31" "16" "35" "16" "669" "73.4" "7.77" "143.72" "16" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf04960, Pf12796, Pf17959" "2744" "ENSG00000115419" "GLS" "hsa:2744; O94925; Q9UL05; Q9UL06; Q9UL07; Q9UN40" "Amino acid metabolism; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells; Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; TP53 Regulates Metabolic Genes; Glutamate and glutamine metabolism" "8" "0" "1.022" "1.011" "1.029" "1.032" "1.053" "0.969" "1.085" "1.125" "0.952" "2611.4" "2668.8" "2639.4" "2688.4" "2696.2" "2750.1" "2529.8" "2832.6" "2938.1" "2485.8" "" "" "" "" "" "" "" "" "" "" "2347.9" "2159.5" "2387.4" "2624.3" "2225.0" "2750.1" "1894.2" "2502.0" "2629.0" "887.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "551881844425109656" "False" "High" "IsMasterProtein" "Q13573" "SNW domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SNW1 PE=1 SV=1" "0.000" "False" "96.072" "40" "17" "32" "17" "536" "61.5" "9.52" "135.42" "17" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf02731" "22938" "ENSG00000100603" "SNW1" "A8K8A9; hsa:22938; Q13483; Q13573; Q32N03; Q5D0D6" "TGF-beta signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Splicing factor NOVA regulated synaptic proteins; Notch signaling pathway" "mRNA Splicing - Major Pathway; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "16" "0" "0.912" "0.972" "0.973" "0.993" "0.986" "0.961" "1.016" "0.966" "0.941" "2967.3" "2707.0" "2882.8" "2888.3" "2947.1" "2927.2" "2851.2" "3014.6" "2865.5" "2792.4" "" "" "" "" "" "" "" "" "" "" "2667.9" "2190.4" "2607.6" "2819.3" "2432.0" "2927.2" "2134.9" "2662.7" "2564.1" "996.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8952953409399985954" "False" "High" "IsMasterProtein" "Q9H1E3" "Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 OS=Homo sapiens OX=9606 GN=NUCKS1 PE=1 SV=1" "0.000" "False" "96.065" "64" "13" "62" "13" "243" "27.3" "5.08" "224.54" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "64710" "ENSG00000069275" "NUCKS1" "hsa:64710; Q54AC0; Q5PXE7; Q9H1D6; Q9H1E3; Q9H723" "" "" "0" "0" "1.027" "0.892" "0.920" "1.019" "1.035" "0.995" "1.105" "0.976" "0.638" "3907.7" "4011.9" "3486.3" "3596.9" "3983.2" "4046.2" "3887.1" "4316.1" "3813.4" "2493.6" "" "" "" "" "" "" "" "" "" "" "3513.4" "3246.3" "3153.5" "3511.1" "3287.0" "4046.2" "2910.6" "3812.2" "3412.2" "890.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4372358057775812967" "False" "High" "IsMasterProtein" "Q9UMZ2" "Synergin gamma OS=Homo sapiens OX=9606 GN=SYNRG PE=1 SV=2" "0.000" "False" "95.966" "21" "22" "31" "22" "1314" "140.6" "5.03" "109.23" "22" "transport" "other membranes;ER/Golgi;other cell component" "" "" "11276" "ENSG00000274047; ENSG00000275066" "SYNRG" "A8MWU4; B7ZKZ2; B7ZKZ3; hsa:11276; Q17RI2; Q5BKU5; Q6ZT17; Q9UMZ2" "17q12 copy number variation syndrome" "" "1" "0" "0.988" "1.007" "0.972" "1.005" "1.011" "1.004" "1.032" "0.978" "0.900" "3376.9" "3335.5" "3401.5" "3281.2" "3392.7" "3415.5" "3390.9" "3485.5" "3302.4" "3039.0" "" "" "" "" "" "" "" "" "" "" "3036.2" "2698.9" "3076.8" "3202.9" "2799.7" "3415.5" "2539.0" "3078.6" "2955.0" "1084.8" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3249613255715037073" "False" "High" "IsMasterProtein" "P30041" "Peroxiredoxin-6 OS=Homo sapiens OX=9606 GN=PRDX6 PE=1 SV=3" "0.000" "False" "95.898" "63" "16" "53" "16" "224" "25.0" "6.38" "193.17" "16" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00578, Pf10417" "9588" "ENSG00000117592" "PRDX6" "A8JZY7; hsa:9588; P30041; P32077; Q5TAH4; Q5ZEZ8" "Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "5" "0" "0.975" "0.945" "0.982" "0.990" "0.910" "0.972" "0.975" "0.973" "0.756" "4208.1" "4104.3" "3974.9" "4130.6" "4164.1" "3831.4" "4089.2" "4102.8" "4093.3" "3182.1" "" "" "" "" "" "" "" "" "" "" "3783.5" "3321.0" "3595.5" "4032.0" "3436.3" "3831.4" "3061.9" "3623.9" "3662.6" "1135.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594033010686828793" "False" "High" "IsMasterProtein" "P48637" "Glutathione synthetase OS=Homo sapiens OX=9606 GN=GSS PE=1 SV=1" "0.000" "False" "95.881" "46" "19" "33" "19" "474" "52.4" "5.92" "125.73" "19" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf03199, Pf03917" "2937" "ENSG00000100983" "GSS" "B2R697; B6F210; E1P5P9; hsa:2937; P48637; Q4TTD9" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Glutathione synthesis and recycling; Defective GSS causes GSS deficiency" "8" "0" "1.014" "0.977" "0.966" "1.001" "1.007" "0.970" "0.975" "0.990" "0.760" "3541.5" "3589.3" "3458.4" "3421.2" "3543.3" "3567.8" "3435.3" "3453.1" "3505.0" "2691.2" "" "" "" "" "" "" "" "" "" "" "3184.1" "2904.3" "3128.2" "3339.6" "2924.0" "3567.8" "2572.3" "3050.0" "3136.3" "960.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "275596885495269995" "False" "High" "IsMasterProtein" "Q14166" "Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens OX=9606 GN=TTLL12 PE=1 SV=2" "0.000" "False" "95.873" "44" "19" "29" "19" "644" "74.4" "5.53" "125.66" "19" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03133" "23170" "ENSG00000100304" "TTLL12" "hsa:23170; Q14166; Q20WK5; Q9UGU3" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.028" "0.955" "1.033" "1.030" "0.955" "1.018" "0.939" "0.957" "2.311" "1869.1" "1921.6" "1784.9" "1930.7" "1924.9" "1784.4" "1903.4" "1755.5" "1788.6" "4319.9" "" "" "" "" "" "" "" "" "" "" "1680.5" "1554.9" "1614.5" "1884.6" "1588.5" "1784.4" "1425.2" "1550.6" "1600.4" "1542.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "721169718826189063" "False" "High" "IsMasterProtein" "Q8IX12" "Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens OX=9606 GN=CCAR1 PE=1 SV=2" "0.000" "False" "95.810" "26" "28" "39" "28" "1150" "132.7" "5.76" "135.03" "28" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf14443, Pf14444, Pf19256, Pf19257" "55749" "ENSG00000060339" "CCAR1" "A0JLT7; A1L4P7; A8K9D4; B4DNP8; B4DRK8; hsa:55749; Q32NE3; Q5EBM3; Q5VUP6; Q6PIZ0; Q6X935; Q8IX12; Q9H8N4; Q9NVA7; Q9NVQ0; Q9NWM6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.890" "0.896" "1.012" "0.831" "0.807" "1.013" "0.806" "0.776" "1.258" "3500.1" "3114.2" "3136.9" "3543.7" "2908.6" "2825.6" "3545.5" "2820.9" "2714.5" "4404.8" "" "" "" "" "" "" "" "" "" "" "3146.9" "2519.9" "2837.4" "3459.1" "2400.2" "2825.6" "2654.8" "2491.6" "2428.9" "1572.4" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031077161766424227" "False" "High" "IsMasterProtein" "Q4V328" "GRIP1-associated protein 1 OS=Homo sapiens OX=9606 GN=GRIPAP1 PE=1 SV=2" "0.000" "False" "95.798" "35" "21" "28" "21" "841" "95.9" "5.11" "112.57" "21" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "" "56850" "ENSG00000068400; ENSG00000292219" "GRIPAP1" "A6NL78; hsa:56850; Q3MJ75; Q4V327; Q4V328; Q4V330; Q5HYG1; Q6N046; Q96DH8; Q9NQ43; Q9ULQ3" "" "" "0" "0" "1.002" "1.119" "0.995" "1.127" "1.067" "1.120" "1.074" "1.050" "1.449" "1182.9" "1185.8" "1323.1" "1177.0" "1333.4" "1262.2" "1325.0" "1270.5" "1242.4" "1713.7" "" "" "" "" "" "" "" "" "" "" "1063.6" "959.5" "1196.8" "1148.9" "1100.4" "1262.2" "992.1" "1122.2" "1111.6" "611.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1679721907195940966" "False" "High" "IsMasterProtein" "P50502" "Hsc70-interacting protein OS=Homo sapiens OX=9606 GN=ST13 PE=1 SV=2" "0.000" "False" "95.790" "32" "11" "60" "11" "369" "41.3" "5.27" "215.08" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf17830, Pf18253" "6767" "ENSG00000100380" "ST13" "hsa:6767; O14999; P50502; Q2TU77" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.899" "0.932" "0.975" "0.954" "0.921" "0.938" "1.027" "0.938" "0.851" "8440.3" "7589.1" "7870.2" "8228.1" "8053.6" "7771.9" "7920.9" "8670.0" "7915.2" "7179.8" "" "" "" "" "" "" "" "" "" "" "7588.6" "6140.9" "7118.8" "8031.7" "6646.0" "7771.9" "5931.0" "7657.9" "7082.5" "2563.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7688952667704275831" "False" "High" "IsMasterProtein" "O14818" "Proteasome subunit alpha type-7 OS=Homo sapiens OX=9606 GN=PSMA7 PE=1 SV=1" "0.000" "False" "95.576" "69" "16" "49" "12" "248" "27.9" "8.46" "190.80" "16" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5688" "ENSG00000101182" "PSMA7" "B2R515; hsa:5688; O14818; Q5JXJ2; Q9BR53; Q9H4K5; Q9UEU8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "4" "1.040" "1.026" "1.088" "1.004" "0.979" "1.027" "1.049" "1.031" "0.822" "4804.8" "4996.7" "4930.8" "5226.1" "4824.9" "4702.9" "4932.5" "5042.7" "4955.7" "3949.1" "" "" "" "" "" "" "" "" "" "" "4320.0" "4043.2" "4460.1" "5101.4" "3981.6" "4702.9" "3693.4" "4454.0" "4434.4" "1409.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8882666347281850930" "False" "High" "IsMasterProtein" "P48739" "Phosphatidylinositol transfer protein beta isoform OS=Homo sapiens OX=9606 GN=PITPNB PE=1 SV=2" "0.000" "False" "95.521" "73" "20" "44" "16" "271" "31.5" "6.87" "157.18" "20" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf02121" "23760" "ENSG00000180957" "PITPNB" "B3KYB8; B7Z7Q0; hsa:23760; P48739; Q8N5W1" "" "PI and PC transport between ER and Golgi membranes" "1" "0" "0.950" "0.945" "0.962" "0.974" "0.913" "0.968" "0.997" "0.968" "0.801" "5171.1" "4914.6" "4888.2" "4976.1" "5039.1" "4721.5" "5007.8" "5156.8" "5005.8" "4144.3" "" "" "" "" "" "" "" "" "" "" "4649.3" "3976.7" "4421.6" "4857.3" "4158.4" "4721.5" "3749.7" "4554.8" "4479.2" "1479.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4128416838288873001" "False" "High" "IsMasterProtein" "P11177" "Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=PDHB PE=1 SV=3" "0.000" "False" "95.403" "43" "12" "32" "12" "359" "39.2" "6.65" "141.45" "12" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02779, Pf02780" "5162" "ENSG00000168291" "PDHB" "B2R7L0; B4DDD7; hsa:5162; P11177; Q6FH45; Q9BQ27; Q9UFK3" "Hereditary leiomyomatosis and renal cell carcinoma pathway; Metabolic reprogramming in colon cancer; Orexin receptor pathway" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "8" "0" "0.942" "0.903" "1.028" "0.892" "0.913" "1.005" "0.914" "0.913" "1.073" "3162.2" "2978.1" "2855.1" "3249.2" "2819.8" "2886.1" "3178.8" "2891.5" "2887.7" "3394.2" "" "" "" "" "" "" "" "" "" "" "2843.2" "2409.8" "2582.6" "3171.7" "2326.9" "2886.1" "2380.2" "2553.9" "2583.9" "1211.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3524975929259860741" "False" "High" "IsMasterProtein" "Q86X27" "Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Homo sapiens OX=9606 GN=RALGPS2 PE=1 SV=1" "0.000" "False" "95.345" "41" "20" "28" "20" "583" "65.1" "8.73" "111.54" "20" "signal transduction" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00169, Pf00617" "55103" "ENSG00000116191" "RALGPS2" "B7Z7B1; hsa:55103; Q5T5Z1; Q5VZ67; Q86X27; Q9NW78" "" "" "0" "0" "0.982" "0.985" "0.991" "0.979" "0.931" "0.980" "1.010" "1.001" "0.945" "4178.8" "4103.9" "4115.6" "4141.2" "4093.0" "3891.8" "4094.1" "4218.8" "4181.7" "3950.0" "" "" "" "" "" "" "" "" "" "" "3757.2" "3320.7" "3722.7" "4042.4" "3377.6" "3891.8" "3065.6" "3726.3" "3741.8" "1410.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1099504193891774007" "False" "High" "IsMasterProtein" "Q13557" "Calcium/calmodulin-dependent protein kinase type II subunit delta OS=Homo sapiens OX=9606 GN=CAMK2D PE=1 SV=3" "0.000" "False" "95.235" "33" "14" "36" "10" "499" "56.3" "7.25" "131.61" "14" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08332" "817" "ENSG00000145349" "CAMK2D" "A8MVS8; hsa:817; Q13557; Q52PK4; Q59G21; Q8N553; Q9UGH6; Q9UQE9" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; SRF and miRs in smooth muscle differentiation and proliferation; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; ErbB signaling pathway" "Signaling by BRAF and RAF1 fusions; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Interferon gamma signaling; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB" "33" "3" "0.999" "0.912" "0.997" "0.974" "0.895" "0.969" "0.978" "0.941" "0.891" "3497.7" "3493.9" "3188.7" "3487.4" "3407.8" "3132.2" "3389.5" "3421.7" "3292.6" "3116.7" "" "" "" "" "" "" "" "" "" "" "3144.8" "2827.1" "2884.3" "3404.2" "2812.2" "3132.2" "2538.0" "3022.3" "2946.2" "1112.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104369569183716546" "False" "High" "IsMasterProtein" "P36915" "Guanine nucleotide-binding protein-like 1 OS=Homo sapiens OX=9606 GN=GNL1 PE=1 SV=2" "0.000" "False" "95.185" "47" "21" "28" "21" "607" "68.6" "5.80" "113.14" "21" "stress response;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf01926" "2794" "ENSG00000204590; ENSG00000206492; ENSG00000226882; ENSG00000228581; ENSG00000229470; ENSG00000232143; ENSG00000235986" "GNL1" "B0S838; hsa:2794; P36915; Q96CT5" "" "" "0" "0" "1.039" "1.067" "0.982" "1.070" "1.085" "1.046" "1.031" "1.098" "0.860" "1797.5" "1866.9" "1918.1" "1765.5" "1923.5" "1951.0" "1880.6" "1853.7" "1973.4" "1546.1" "" "" "" "" "" "" "" "" "" "" "1616.1" "1510.6" "1735.0" "1723.4" "1587.3" "1951.0" "1408.1" "1637.3" "1765.8" "551.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8479423548841098522" "False" "High" "IsMasterProtein" "P21283" "V-type proton ATPase subunit C 1 OS=Homo sapiens OX=9606 GN=ATP6V1C1 PE=1 SV=4" "0.000" "False" "95.084" "52" "21" "47" "21" "382" "43.9" "7.46" "170.76" "21" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf03223" "528" "ENSG00000155097" "ATP6V1C1" "hsa:528; P21283" "Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "1.007" "1.045" "0.968" "1.017" "1.005" "0.972" "1.028" "1.045" "1.078" "4271.6" "4303.0" "4462.9" "4137.0" "4345.0" "4291.3" "4151.5" "4391.8" "4463.0" "4603.5" "" "" "" "" "" "" "" "" "" "" "3840.6" "3481.9" "4036.8" "4038.3" "3585.5" "4291.3" "3108.6" "3879.2" "3993.5" "1643.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2017615054723730630" "False" "High" "IsMasterProtein" "Q6N069" "N-alpha-acetyltransferase 16, NatA auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA16 PE=1 SV=2" "0.000" "False" "95.033" "25" "24" "42" "16" "864" "101.4" "7.87" "128.15" "24" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf07719, Pf12569" "79612" "ENSG00000172766" "NAA16" "B0QZ59; hsa:79612; Q5VSP9; Q6N069; Q6P2D5; Q8N5J3; Q8N870" "" "" "0" "0" "0.960" "0.951" "0.929" "0.932" "0.917" "0.955" "0.856" "0.901" "1.370" "1562.1" "1500.1" "1484.8" "1450.5" "1455.8" "1432.5" "1491.6" "1336.7" "1407.9" "2140.2" "" "" "" "" "" "" "" "" "" "" "1404.5" "1213.9" "1343.1" "1415.9" "1201.3" "1432.5" "1116.9" "1180.6" "1259.8" "764.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1669697587989024487" "False" "High" "IsMasterProtein" "Q96FW1" "Ubiquitin thioesterase OTUB1 OS=Homo sapiens OX=9606 GN=OTUB1 PE=1 SV=2" "0.000" "False" "94.971" "52" "12" "38" "12" "271" "31.3" "4.94" "166.40" "12" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf10275" "55611" "ENSG00000167770" "OTUB1" "hsa:55611; Q32Q78; Q96FW1; Q96II3; Q9NXQ4; Q9P0B8" "" "Ub-specific processing proteases; Ovarian tumor domain proteases" "2" "0" "0.968" "1.004" "1.012" "1.025" "0.975" "1.022" "1.008" "1.032" "0.874" "3530.3" "3417.8" "3545.6" "3572.2" "3617.8" "3441.7" "3606.7" "3559.1" "3643.7" "3086.2" "" "" "" "" "" "" "" "" "" "" "3174.1" "2765.6" "3207.1" "3487.0" "2985.5" "3441.7" "2700.6" "3143.6" "3260.4" "1101.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662139928789152118" "False" "High" "IsMasterProtein" "Q8WYJ6" "Septin-1 OS=Homo sapiens OX=9606 GN=SEPTIN1 PE=1 SV=3" "0.000" "False" "94.956" "54" "16" "34" "16" "372" "42.4" "5.80" "126.54" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00735" "1731" "ENSG00000180096" "SEPTIN1" "B4DVE6; hsa:1731; Q658T1; Q8NEZ1; Q8WYJ6; Q96EL4; Q9H285" "" "" "0" "0" "1.007" "0.976" "0.994" "1.032" "1.007" "1.027" "1.041" "0.998" "0.867" "3169.1" "3190.4" "3093.3" "3150.5" "3269.5" "3189.9" "3255.7" "3300.3" "3161.6" "2746.1" "" "" "" "" "" "" "" "" "" "" "2849.4" "2581.5" "2798.0" "3075.3" "2698.1" "3189.9" "2437.8" "2915.0" "2829.0" "980.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6101173507286650100" "False" "High" "IsMasterProtein" "O43852" "Calumenin OS=Homo sapiens OX=9606 GN=CALU PE=1 SV=2" "0.000" "False" "94.529" "57" "14" "46" "14" "315" "37.1" "4.64" "165.93" "14" "" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13202" "813" "ENSG00000128595" "CALU" "B3KPG9; D6QS48; D6QS49; D6QS50; D6QS51; D6QS52; D6QS53; D6QS54; D6QS55; D6QS56; D6QS57; D6QS58; D6QS59; F5H1Q9; F5H879; hsa:813; O43852; O60456; Q6FHB9; Q96RL3; Q9NR43" "NOTCH1 regulation of endothelial cell calcification; VEGFA-VEGFR2 signaling" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "5" "0" "0.921" "0.949" "0.959" "0.944" "0.964" "0.950" "0.986" "0.966" "0.838" "4696.4" "4327.3" "4455.7" "4505.6" "4433.7" "4529.1" "4460.3" "4630.7" "4535.8" "3934.2" "" "" "" "" "" "" "" "" "" "" "4222.5" "3501.5" "4030.3" "4398.1" "3658.8" "4529.1" "3339.7" "4090.1" "4058.6" "1404.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6241342632728061571" "False" "High" "IsMasterProtein" "O43148" "mRNA cap guanine-N7 methyltransferase OS=Homo sapiens OX=9606 GN=RNMT PE=1 SV=1" "0.000" "False" "94.506" "44" "18" "32" "18" "476" "54.8" "6.61" "122.22" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03291" "8731" "ENSG00000101654" "RNMT" "B0YJ90; D3DUJ5; hsa:8731; O43148; O94996; Q9UIJ9" "mRNA processing; 15q25 copy number variation" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "0.994" "0.995" "1.029" "1.040" "0.978" "0.985" "1.027" "1.017" "0.816" "2549.8" "2533.6" "2535.9" "2624.0" "2651.9" "2492.9" "2512.0" "2619.6" "2594.3" "2080.3" "" "" "" "" "" "" "" "" "" "" "2292.5" "2050.1" "2293.8" "2561.4" "2188.4" "2492.9" "1880.9" "2313.8" "2321.3" "742.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7061207721996529093" "False" "High" "IsMasterProtein" "P08758" "Annexin A5 OS=Homo sapiens OX=9606 GN=ANXA5 PE=1 SV=2" "0.000" "False" "94.408" "61" "20" "38" "19" "320" "35.9" "5.05" "122.84" "20" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "308" "ENSG00000164111" "ANXA5" "D3DNW7; hsa:308; P08758; Q6FHB3; Q6FI16; Q8WV69; Q9UDH9" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Interactions between LOXL4 and oxidative stress pathway; Prostaglandin synthesis and regulation" "Platelet degranulation" "4" "1" "1.049" "1.056" "0.996" "1.091" "1.067" "1.113" "1.062" "1.074" "0.941" "2930.5" "3073.5" "3094.4" "2917.9" "3197.5" "3126.9" "3261.6" "3113.4" "3145.9" "2758.3" "" "" "" "" "" "" "" "" "" "" "2634.8" "2486.9" "2799.0" "2848.3" "2638.7" "3126.9" "2442.2" "2750.0" "2814.9" "984.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4481377694352566724" "False" "High" "IsMasterProtein" "P15121" "Aldo-keto reductase family 1 member B1 OS=Homo sapiens OX=9606 GN=AKR1B1 PE=1 SV=3" "0.000" "False" "94.322" "54" "15" "57" "14" "316" "35.8" "6.98" "192.01" "15" "other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus" "other molecular function" "Pf00248" "231" "ENSG00000085662" "AKR1B1" "B2R8N3; hsa:231; P15121; Q5U031; Q6FGA4; Q6ICP2; Q9BS21; Q9UCI9" "Eicosanoid metabolism via cyclooxygenases (COX); Disorders of galactose metabolism ; Omega-6-fatty acids in senescence; Polyol pathway; Metapathway biotransformation Phase I and II" "Pregnenolone biosynthesis; Fructose biosynthesis" "7" "0" "0.982" "1.083" "1.042" "1.011" "1.010" "1.007" "0.997" "1.046" "0.818" "3905.9" "3835.3" "4231.2" "4069.4" "3949.0" "3944.0" "3933.7" "3892.5" "4085.3" "3196.7" "" "" "" "" "" "" "" "" "" "" "3511.8" "3103.4" "3827.3" "3972.3" "3258.8" "3944.0" "2945.4" "3438.1" "3655.5" "1141.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3101677286908017403" "False" "High" "IsMasterProtein" "Q9Y450" "HBS1-like protein OS=Homo sapiens OX=9606 GN=HBS1L PE=1 SV=1" "0.000" "False" "94.298" "41" "24" "35" "24" "684" "75.4" "6.61" "131.13" "24" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03143, Pf03144, Pf08938" "10767" "ENSG00000112339" "HBS1L" "B7Z365; hsa:10767; Q4VX89; Q4VX90; Q5T7G3; Q8NDW9; Q9UPW3; Q9Y450" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.024" "1.028" "0.925" "0.976" "0.974" "0.972" "0.939" "0.951" "0.866" "3615.3" "3702.5" "3715.5" "3345.1" "3529.2" "3519.8" "3512.8" "3393.6" "3438.6" "3130.1" "" "" "" "" "" "" "" "" "" "" "3250.5" "2995.9" "3360.8" "3265.2" "2912.4" "3519.8" "2630.3" "2997.5" "3076.8" "1117.3" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5859818642723021868" "False" "High" "IsMasterProtein" "Q96RS6" "NudC domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NUDCD1 PE=1 SV=2" "0.000" "False" "94.218" "43" "19" "32" "19" "583" "66.7" "5.11" "136.60" "19" "other biological processes" "cytosol;nucleus" "" "Pf04969" "84955" "ENSG00000120526" "NUDCD1" "B4DVX6; hsa:84955; Q4G130; Q8NDQ5; Q8NG18; Q96RS6; Q96SI4; Q9BVR5" "" "" "0" "0" "1.022" "1.050" "1.066" "1.023" "1.166" "1.036" "0.974" "1.067" "0.843" "1801.6" "1841.2" "1892.4" "1920.5" "1843.6" "2101.5" "1866.3" "1754.5" "1922.0" "1519.0" "" "" "" "" "" "" "" "" "" "" "1619.8" "1489.9" "1711.8" "1874.6" "1521.4" "2101.5" "1397.5" "1549.7" "1719.8" "542.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028893805167112372" "False" "High" "IsMasterProtein" "O75351" "Vacuolar protein sorting-associated protein 4B OS=Homo sapiens OX=9606 GN=VPS4B PE=1 SV=2" "0.000" "False" "94.092" "47" "19" "40" "14" "444" "49.3" "7.23" "136.21" "19" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "9525" "ENSG00000119541" "VPS4B" "hsa:9525; O75351; Q69HW4; Q9GZS7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "3" "0.990" "0.991" "0.996" "1.053" "1.027" "1.043" "1.078" "1.036" "0.874" "3340.4" "3306.3" "3309.8" "3326.6" "3518.7" "3430.9" "3483.1" "3600.7" "3460.4" "2919.0" "" "" "" "" "" "" "" "" "" "" "3003.4" "2675.3" "2993.9" "3247.3" "2903.7" "3430.9" "2608.1" "3180.3" "3096.3" "1042.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3054856418516569750" "False" "High" "IsMasterProtein" "Q8IZ07" "Ankyrin repeat domain-containing protein 13A OS=Homo sapiens OX=9606 GN=ANKRD13A PE=1 SV=3" "0.000" "False" "94.031" "35" "16" "34" "16" "590" "67.6" "5.02" "137.95" "16" "other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11904, Pf12796" "88455" "ENSG00000076513" "ANKRD13A" "hsa:88455; O60736; Q8IZ07" "" "" "0" "0" "1.054" "1.029" "1.014" "1.085" "1.036" "1.070" "1.025" "1.050" "0.898" "2552.3" "2690.2" "2625.3" "2587.8" "2769.0" "2644.8" "2730.1" "2615.0" "2680.3" "2291.4" "" "" "" "" "" "" "" "" "" "" "2294.8" "2176.8" "2374.7" "2526.0" "2285.0" "2644.8" "2044.2" "2309.8" "2398.3" "818.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2666399162137355267" "False" "High" "IsMasterProtein" "P38117" "Electron transfer flavoprotein subunit beta OS=Homo sapiens OX=9606 GN=ETFB PE=1 SV=3" "0.000" "False" "94.009" "65" "17" "53" "17" "255" "27.8" "8.10" "182.01" "17" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01012" "2109" "ENSG00000105379" "ETFB" "A8K766; B3KNY2; hsa:2109; P38117; Q6IBH7; Q71RF6; Q9Y3S7" "" "Respiratory electron transport; Protein methylation" "2" "0" "0.997" "1.027" "1.013" "0.989" "0.995" "0.991" "1.018" "0.992" "0.768" "3452.3" "3440.8" "3546.8" "3496.1" "3414.5" "3436.1" "3420.2" "3515.3" "3423.8" "2651.2" "" "" "" "" "" "" "" "" "" "" "3103.9" "2784.1" "3208.2" "3412.7" "2817.7" "3436.1" "2561.0" "3104.9" "3063.6" "946.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381164833794741619" "False" "High" "IsMasterProtein" "Q9Y5K6" "CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1" "0.000" "False" "93.920" "39" "25" "37" "25" "639" "71.4" "6.40" "131.71" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf07653, Pf14604" "23607" "ENSG00000198087" "CD2AP" "A6NL34; hsa:23607; Q5VYA3; Q9UG97; Q9Y5K6" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome; Genes controlling nephrogenesis; GDNF signaling" "Nephrin family interactions" "5" "0" "1.008" "1.031" "1.044" "1.030" "1.011" "1.022" "1.036" "1.041" "0.944" "3438.1" "3465.9" "3546.2" "3588.7" "3541.1" "3475.6" "3515.1" "3562.0" "3580.6" "3244.2" "" "" "" "" "" "" "" "" "" "" "3091.1" "2804.5" "3207.7" "3503.1" "2922.2" "3475.6" "2632.0" "3146.2" "3203.9" "1158.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1707703891335855171" "False" "High" "IsMasterProtein" "Q7Z478" "ATP-dependent RNA helicase DHX29 OS=Homo sapiens OX=9606 GN=DHX29 PE=1 SV=2" "0.000" "False" "93.746" "21" "28" "32" "27" "1369" "155.1" "8.09" "107.20" "28" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "54505" "ENSG00000067248" "DHX29" "hsa:54505; O75549; Q63HN0; Q63HN3; Q7Z478; Q8IWW2; Q8N3A1; Q9UMH2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.091" "1.156" "0.941" "1.090" "1.166" "1.022" "0.992" "1.106" "0.995" "2501.2" "2729.1" "2890.7" "2353.8" "2726.2" "2917.4" "2555.7" "2480.9" "2766.9" "2488.1" "" "" "" "" "" "" "" "" "" "" "2248.8" "2208.3" "2614.8" "2297.7" "2249.7" "2917.4" "1913.6" "2191.3" "2475.8" "888.2" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1845786618234347704" "False" "High" "IsMasterProtein" "P55263" "Adenosine kinase OS=Homo sapiens OX=9606 GN=ADK PE=1 SV=2" "0.000" "False" "93.556" "56" "17" "32" "17" "362" "40.5" "6.70" "133.27" "17" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00294" "132" "ENSG00000156110" "ADK" "B7Z783; B7Z800; hsa:132; O00741; O00742; P55263; Q16710; Q5JQ10; Q5JQ11; Q9BTN2" "Methionine metabolism leading to sulfur amino acids and related disorders" "Ribavirin ADME; Purine salvage" "3" "0" "0.972" "0.981" "1.028" "0.994" "0.986" "0.974" "1.018" "0.967" "0.813" "2801.0" "2721.8" "2748.2" "2878.8" "2784.9" "2760.9" "2728.1" "2852.8" "2707.8" "2278.4" "" "" "" "" "" "" "" "" "" "" "2518.4" "2202.4" "2485.8" "2810.1" "2298.1" "2760.9" "2042.7" "2519.8" "2422.9" "813.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6898362588139573585" "False" "High" "IsMasterProtein" "Q01105" "Protein SET OS=Homo sapiens OX=9606 GN=SET PE=1 SV=3" "0.000" "False" "93.477" "45" "10" "88" "10" "290" "33.5" "4.32" "371.05" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00956" "6418" "ENSG00000119335" "SET" "A5A5H4; A6NGV1; B4DUE2; hsa:6418; Q01105; Q15541; Q5VXV1; Q5VXV2; Q6FHZ5" "Histone modifications; VEGFA-VEGFR2 signaling" "HuR (ELAVL1) binds and stabilizes mRNA; Condensation of Prophase Chromosomes" "4" "0" "0.893" "0.898" "0.909" "0.933" "0.891" "0.921" "0.901" "0.874" "0.782" "7679.5" "6861.5" "6899.9" "6978.3" "7168.7" "6839.5" "7073.1" "6917.8" "6708.9" "6001.7" "" "" "" "" "" "" "" "" "" "" "6904.6" "5552.1" "6241.2" "6811.8" "5915.7" "6839.5" "5296.1" "6110.3" "6003.1" "2142.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8364348392468163032" "False" "High" "IsMasterProtein" "P04040" "Catalase OS=Homo sapiens OX=9606 GN=CAT PE=1 SV=3" "0.000" "False" "93.437" "39" "21" "34" "21" "527" "59.7" "7.39" "123.92" "21" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00199, Pf06628" "847" "ENSG00000121691" "CAT" "A8K6C0; B2RCZ9; D3DR07; hsa:847; P04040; Q2M1U4; Q4VXX5; Q9BWT9; Q9UC85" "Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Oxidative stress response; Tryptophan metabolism; Male infertility; Arsenic metabolism and reactive oxygen species generation; DNA damage response (only ATM dependent)" "Peroxisomal protein import; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Neutrophil degranulation; Detoxification of Reactive Oxygen Species" "12" "0" "1.027" "1.083" "1.046" "1.074" "1.028" "1.014" "0.974" "1.100" "0.887" "1984.3" "2038.1" "2148.6" "2075.3" "2131.2" "2039.0" "2011.2" "1932.1" "2182.0" "1760.3" "" "" "" "" "" "" "" "" "" "" "1784.1" "1649.1" "1943.4" "2025.7" "1758.7" "2039.0" "1505.9" "1706.5" "1952.5" "628.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8425175822669482526" "False" "High" "IsMasterProtein" "Q9NRY5" "Protein FAM114A2 OS=Homo sapiens OX=9606 GN=FAM114A2 PE=1 SV=4" "0.000" "False" "93.416" "36" "17" "27" "17" "505" "55.4" "4.88" "115.13" "17" "" "" "other molecular function" "Pf05334" "10827" "ENSG00000055147" "FAM114A2" "B2R8D8; hsa:10827; Q9H7E0; Q9NRY5" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "1.015" "1.040" "0.980" "1.037" "0.991" "1.057" "1.037" "1.080" "0.965" "2358.2" "2393.6" "2451.4" "2311.1" "2445.1" "2337.2" "2492.6" "2444.5" "2545.8" "2275.5" "" "" "" "" "" "" "" "" "" "" "2120.2" "1936.8" "2217.4" "2256.0" "2017.7" "2337.2" "1866.4" "2159.2" "2277.9" "812.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926750901402698685" "False" "High" "IsMasterProtein" "Q9UKG1" "DCC-interacting protein 13-alpha OS=Homo sapiens OX=9606 GN=APPL1 PE=1 SV=1" "0.000" "False" "93.403" "36" "20" "37" "20" "709" "79.6" "5.41" "126.38" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00640, Pf16746" "26060" "ENSG00000157500" "APPL1" "hsa:26060; Q9P2B9; Q9UKG1" "Follicle stimulating hormone (FSH) signaling pathway; Chromosomal and microsatellite instability in colorectal cancer" "Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "1.001" "1.014" "0.986" "1.027" "0.993" "1.038" "1.023" "1.018" "0.936" "1957.9" "1960.4" "1986.1" "1931.2" "2011.3" "1945.2" "2032.5" "2003.2" "1993.5" "1833.2" "" "" "" "" "" "" "" "" "" "" "1760.4" "1586.3" "1796.5" "1885.1" "1659.8" "1945.2" "1521.9" "1769.3" "1783.7" "654.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9192930488046834202" "False" "High" "IsMasterProtein" "P25789" "Proteasome subunit alpha type-4 OS=Homo sapiens OX=9606 GN=PSMA4 PE=1 SV=1" "0.000" "False" "93.369" "61" "15" "45" "15" "261" "29.5" "7.72" "198.62" "15" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227, Pf10584" "5685" "ENSG00000041357" "PSMA4" "D3DW86; hsa:5685; P25789; Q53XP2; Q567Q5; Q8TBD1" "Proteasome degradation; Alzheimer's disease and miRNA effects; Exercise-induced circadian regulation; Alzheimer's disease" "MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "1.052" "1.017" "1.050" "1.030" "0.989" "1.000" "1.052" "1.032" "0.846" "4543.9" "4778.0" "4620.4" "4770.0" "4680.9" "4493.0" "4545.1" "4779.8" "4690.6" "3843.0" "" "" "" "" "" "" "" "" "" "" "4085.4" "3866.2" "4179.3" "4656.2" "3862.8" "4493.0" "3403.3" "4221.8" "4197.1" "1371.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8470400305204825802" "False" "High" "IsMasterProtein" "Q9Y485" "DmX-like protein 1 OS=Homo sapiens OX=9606 GN=DMXL1 PE=1 SV=3" "0.000" "False" "93.364" "10" "27" "32" "27" "3027" "337.6" "6.34" "113.64" "27" "other biological processes" "other cell component" "" "Pf00400, Pf12234" "1657" "ENSG00000172869" "DMXL1" "hsa:1657; Q9Y485" "" "" "0" "0" "1.008" "0.996" "0.968" "1.054" "0.975" "1.050" "0.990" "1.036" "1.099" "2587.1" "2607.4" "2577.2" "2503.0" "2726.2" "2522.5" "2716.8" "2561.4" "2679.5" "2842.4" "" "" "" "" "" "" "" "" "" "" "2326.1" "2109.8" "2331.2" "2443.3" "2249.7" "2522.5" "2034.3" "2262.4" "2397.6" "1014.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6373190460563601224" "False" "High" "IsMasterProtein" "Q7L014" "Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens OX=9606 GN=DDX46 PE=1 SV=2" "0.000" "False" "93.260" "25" "24" "30" "24" "1031" "117.3" "9.29" "104.43" "24" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;nucleus" "other molecular function" "Pf00270, Pf00271" "9879" "ENSG00000145833" "DDX46" "hsa:9879; O94894; Q7L014; Q96EI0; Q9Y658" "" "mRNA Splicing - Major Pathway" "1" "0" "0.998" "0.992" "0.926" "1.018" "1.023" "0.977" "0.907" "0.974" "0.943" "2955.2" "2949.7" "2930.3" "2738.0" "3007.7" "3022.1" "2888.6" "2681.3" "2877.2" "2786.6" "" "" "" "" "" "" "" "" "" "" "2657.0" "2386.8" "2650.6" "2672.6" "2482.0" "3022.1" "2162.9" "2368.3" "2574.5" "994.7" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "439747598683617185" "False" "High" "IsMasterProtein" "Q9UI10" "Translation initiation factor eIF2B subunit delta OS=Homo sapiens OX=9606 GN=EIF2B4 PE=1 SV=2" "0.000" "False" "93.162" "41" "17" "28" "17" "523" "57.5" "9.38" "112.22" "17" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8890" "ENSG00000115211" "EIF2B4" "hsa:8890; Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UI10; Q9UIQ9; Q9UJ95" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "1.032" "0.902" "0.945" "1.033" "0.945" "0.956" "0.936" "0.984" "0.797" "1776.7" "1834.1" "1603.0" "1678.8" "1834.6" "1678.1" "1698.6" "1663.2" "1747.6" "1416.2" "" "" "" "" "" "" "" "" "" "" "1597.5" "1484.1" "1449.9" "1638.8" "1513.9" "1678.1" "1271.9" "1469.0" "1563.7" "505.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4495210949063335174" "False" "High" "IsMasterProtein" "Q7L576" "Cytoplasmic FMR1-interacting protein 1 OS=Homo sapiens OX=9606 GN=CYFIP1 PE=1 SV=1" "0.000" "False" "93.139" "15" "17" "35" "1" "1253" "145.1" "6.90" "117.80" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf05994, Pf07159" "23191" "ENSG00000273749; ENSG00000288461" "CYFIP1" "A8K6D9; hsa:23191; Q14467; Q5IED0; Q6ZSX1; Q7L576; Q9BSD9; Q9BVC7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; G13 signaling pathway" "Neutrophil degranulation; VEGFA-VEGFR2 Pathway; RAC3 GTPase cycle; RAC1 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOG GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle" "15" "0" "0.911" "0.868" "1.088" "0.875" "0.971" "0.895" "0.986" "1.053" "0.910" "329.1" "299.7" "285.7" "358.1" "288.0" "319.6" "294.4" "324.3" "346.6" "299.3" "" "" "" "" "" "" "" "" "" "" "295.9" "242.5" "258.4" "349.6" "237.7" "319.6" "220.5" "286.5" "310.1" "106.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3818146926309850822" "False" "High" "IsMasterProtein" "O95671" "Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein OS=Homo sapiens OX=9606 GN=ASMTL PE=1 SV=3" "0.000" "False" "92.889" "40" "23" "38" "23" "621" "68.8" "6.07" "142.36" "23" "other metabolic processes" "cytosol" "other molecular function" "Pf00891, Pf02545, Pf16864" "8623" "ENSG00000169093; ENSG00000292339" "ASMTL" "B4DX75; F5GXH4; hsa:8623; J3JS33; O95671; Q5JQ53; Q8NBH5; Q96G02; Q9BUL6" "" "" "0" "0" "1.032" "1.047" "1.010" "0.995" "1.017" "0.983" "0.980" "1.049" "0.857" "2925.2" "3019.7" "3062.9" "2953.7" "2909.2" "2974.4" "2874.0" "2866.9" "3069.4" "2506.2" "" "" "" "" "" "" "" "" "" "" "2630.0" "2443.4" "2770.5" "2883.2" "2400.7" "2974.4" "2152.0" "2532.3" "2746.5" "894.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3313635736816900772" "False" "High" "IsMasterProtein" "O96019" "Actin-like protein 6A OS=Homo sapiens OX=9606 GN=ACTL6A PE=1 SV=1" "0.000" "False" "92.864" "39" "13" "37" "13" "429" "47.4" "5.60" "132.62" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00022" "86" "ENSG00000136518" "ACTL6A" "B3KMN1; D3DNR9; hsa:86; O96019; Q8TAE5; Q9BVS8; Q9H0W6" "Androgen receptor network in prostate cancer; Gastric cancer network 1; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RMTs methylate histone arginines; UCH proteinases; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; HATs acetylate histones; DNA Damage Recognition in GG-NER" "10" "0" "1.006" "0.934" "1.009" "1.005" "0.965" "0.977" "0.954" "0.992" "1.043" "3296.3" "3317.0" "3079.0" "3326.2" "3311.3" "3179.8" "3218.9" "3143.1" "3270.9" "3438.0" "" "" "" "" "" "" "" "" "" "" "2963.7" "2684.0" "2785.0" "3246.9" "2732.6" "3179.8" "2410.2" "2776.2" "2926.8" "1227.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6990547013884615551" "False" "High" "IsMasterProtein" "Q5JSH3" "WD repeat-containing protein 44 OS=Homo sapiens OX=9606 GN=WDR44 PE=1 SV=1" "0.000" "False" "92.850" "29" "22" "31" "22" "913" "101.3" "5.45" "119.62" "22" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "54521" "ENSG00000131725" "WDR44" "B4DSE9; F8W913; hsa:54521; Q0JS52; Q0JTF3; Q5JSH2; Q5JSH3; Q6ZSC1; Q7Z365; Q7Z3P6; Q8NAU8; Q8NHU5; Q9NUV4" "Ectoderm differentiation" "" "1" "0" "1.009" "0.954" "0.997" "1.030" "0.919" "0.984" "0.998" "0.961" "0.848" "2564.2" "2588.2" "2446.7" "2555.5" "2641.7" "2356.2" "2522.6" "2560.4" "2463.4" "2173.5" "" "" "" "" "" "" "" "" "" "" "2305.5" "2094.3" "2213.1" "2494.5" "2179.9" "2356.2" "1888.9" "2261.5" "2204.2" "775.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965270540937199853" "False" "High" "IsMasterProtein" "Q14151" "Scaffold attachment factor B2 OS=Homo sapiens OX=9606 GN=SAFB2 PE=1 SV=1" "0.000" "False" "92.707" "24" "19" "33" "12" "953" "107.4" "6.16" "124.98" "19" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02037" "9667" "ENSG00000130254" "SAFB2" "B4DKG3; hsa:9667; Q14151; Q8TB13" "" "" "0" "0" "0.989" "0.910" "0.944" "0.974" "1.029" "0.988" "0.972" "0.931" "1.009" "1788.2" "1768.2" "1627.0" "1688.8" "1742.1" "1839.7" "1767.2" "1737.5" "1664.8" "1804.3" "" "" "" "" "" "" "" "" "" "" "1607.8" "1430.8" "1471.7" "1648.5" "1437.6" "1839.7" "1323.2" "1534.7" "1489.7" "644.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244898098371361519" "False" "High" "IsMasterProtein" "Q86VS8" "Protein Hook homolog 3 OS=Homo sapiens OX=9606 GN=HOOK3 PE=1 SV=2" "0.000" "False" "92.678" "39" "27" "36" "27" "718" "83.1" "5.17" "125.33" "27" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf05622, Pf19047" "84376" "ENSG00000168172" "HOOK3" "D3DSY8; hsa:84376; Q86VS8; Q8NBH0; Q9BY13" "" "" "0" "0" "1.040" "1.054" "1.032" "1.074" "1.066" "1.085" "1.057" "1.097" "1.154" "3176.1" "3302.5" "3346.6" "3276.6" "3410.6" "3384.5" "3444.7" "3356.2" "3483.5" "3664.1" "" "" "" "" "" "" "" "" "" "" "2855.6" "2672.2" "3027.1" "3198.5" "2814.5" "3384.5" "2579.3" "2964.4" "3117.0" "1308.0" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6610589870849209696" "False" "High" "IsMasterProtein" "Q9NZ63" "Splicing factor C9orf78 OS=Homo sapiens OX=9606 GN=C9orf78 PE=1 SV=1" "0.000" "False" "92.263" "66" "17" "36" "17" "289" "33.7" "6.74" "130.02" "17" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07052" "51759" "ENSG00000136819" "C9orf78" "B3KPX8; Q8WVU6; Q9NT39; Q9NZ63" "" "mRNA Splicing - Major Pathway" "1" "0" "0.902" "1.012" "0.977" "0.985" "1.015" "0.989" "1.039" "1.010" "0.784" "3106.0" "2802.8" "3143.0" "3034.7" "3058.4" "3152.0" "3072.5" "3227.0" "3137.0" "2436.0" "" "" "" "" "" "" "" "" "" "" "2792.6" "2267.9" "2842.9" "2962.3" "2523.8" "3152.0" "2300.6" "2850.3" "2806.9" "869.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2093622632730469128" "False" "High" "IsMasterProtein" "Q15418" "Ribosomal protein S6 kinase alpha-1 OS=Homo sapiens OX=9606 GN=RPS6KA1 PE=1 SV=2" "0.000" "False" "92.213" "37" "26" "34" "17" "735" "82.7" "7.83" "125.02" "26" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6195" "ENSG00000117676; ENSG00000281877" "RPS6KA1" "A6NGG4; A8K9K7; B2RDY8; B7Z5J0; E9PRI4; hsa:6195; Q15418; Q5SVM5; Q5SVM8; Q5SVM9; Q96C05; Q9BQK2" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; TYROBP causal network in microglia; Thermogenesis; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map" "CREB phosphorylation; Recycling pathway of L1; Senescence-Associated Secretory Phenotype (SASP); RSK activation; ERK/MAPK targets; Gastrin-CREB signalling pathway via PKC and MAPK" "26" "7" "0.972" "1.006" "0.990" "0.956" "0.937" "0.987" "0.964" "0.944" "1.107" "3327.2" "3235.3" "3347.7" "3295.2" "3181.6" "3116.7" "3285.3" "3206.5" "3142.2" "3682.7" "" "" "" "" "" "" "" "" "" "" "2991.5" "2617.9" "3028.1" "3216.5" "2625.5" "3116.7" "2460.0" "2832.2" "2811.6" "1314.6" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406338825216404645" "False" "High" "IsMasterProtein" "Q16740" "ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens OX=9606 GN=CLPP PE=1 SV=1" "0.000" "False" "92.107" "42" "9" "44" "9" "277" "30.2" "8.09" "168.93" "9" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00574" "8192" "ENSG00000125656" "CLPP" "B2R4W5; hsa:8192; Q16740" "Primary ovarian insufficiency" "Mitochondrial protein degradation" "2" "0" "0.989" "0.992" "1.013" "1.037" "1.005" "0.971" "1.025" "0.994" "0.860" "3664.0" "3622.2" "3633.8" "3713.3" "3798.3" "3683.0" "3557.5" "3756.0" "3641.5" "3152.9" "" "" "" "" "" "" "" "" "" "" "3294.3" "2931.0" "3286.9" "3624.7" "3134.4" "3683.0" "2663.8" "3317.5" "3258.4" "1125.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7164252361216930989" "False" "High" "IsMasterProtein" "P27707" "Deoxycytidine kinase OS=Homo sapiens OX=9606 GN=DCK PE=1 SV=1" "0.000" "False" "92.081" "45" "12" "41" "12" "260" "30.5" "5.21" "168.13" "12" "other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf01712" "1633" "ENSG00000156136" "DCK" "B2R8V6; hsa:1633; P27707; Q5TZY7; Q6FI11" "Retinoblastoma gene in cancer; Pyrimidine metabolism" "Pyrimidine salvage; Purine salvage" "4" "0" "0.988" "0.937" "0.956" "1.003" "0.863" "0.961" "1.010" "0.927" "0.716" "4501.0" "4449.2" "4215.6" "4304.1" "4513.3" "3883.8" "4324.0" "4545.1" "4174.4" "3223.1" "" "" "" "" "" "" "" "" "" "" "4046.8" "3600.2" "3813.2" "4201.4" "3724.5" "3883.8" "3237.7" "4014.6" "3735.3" "1150.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4204109305997435954" "False" "High" "IsMasterProtein" "Q07960" "Rho GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARHGAP1 PE=1 SV=1" "0.000" "False" "91.972" "46" "16" "37" "16" "439" "50.4" "6.29" "140.58" "16" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf13716" "392" "ENSG00000175220" "ARHGAP1" "D3DQQ6; hsa:392; Q07960" "" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOC GTPase cycle; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "13" "0" "1.029" "1.025" "1.011" "1.064" "0.999" "1.068" "1.012" "1.035" "0.928" "2041.0" "2099.9" "2091.4" "2063.4" "2171.7" "2039.0" "2180.2" "2065.2" "2113.4" "1894.6" "" "" "" "" "" "" "" "" "" "" "1835.1" "1699.2" "1891.7" "2014.1" "1792.1" "2039.0" "1632.4" "1824.1" "1891.0" "676.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1188306556528865133" "False" "High" "IsMasterProtein" "Q15691" "Microtubule-associated protein RP/EB family member 1 OS=Homo sapiens OX=9606 GN=MAPRE1 PE=1 SV=3" "0.000" "False" "91.752" "58" "12" "44" "11" "268" "30.0" "5.14" "170.70" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22919" "ENSG00000101367" "MAPRE1" "B2R6I7; E1P5M8; hsa:22919; Q15691; Q3KQS8" "Microtubule cytoskeleton regulation; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "16" "0" "1.010" "1.013" "1.051" "0.989" "1.008" "0.973" "1.006" "0.991" "0.867" "3296.4" "3330.3" "3339.2" "3465.6" "3259.3" "3322.8" "3207.6" "3315.9" "3268.0" "2856.5" "" "" "" "" "" "" "" "" "" "" "2963.8" "2694.8" "3020.4" "3382.9" "2689.6" "3322.8" "2401.7" "2928.8" "2924.2" "1019.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7260357318160893257" "False" "High" "IsMasterProtein" "O75439" "Mitochondrial-processing peptidase subunit beta OS=Homo sapiens OX=9606 GN=PMPCB PE=1 SV=2" "0.000" "False" "91.708" "35" "16" "37" "15" "489" "54.3" "6.83" "150.47" "16" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion" "other molecular function" "Pf00675, Pf05193" "9512" "ENSG00000105819" "PMPCB" "hsa:9512; O60416; O75439; Q96FV4" "" "Mitochondrial protein import; Processing of SMDT1" "2" "1" "1.001" "1.025" "1.019" "0.990" "0.981" "0.990" "0.982" "1.017" "0.959" "3304.4" "3308.4" "3388.4" "3367.8" "3272.2" "3242.3" "3272.4" "3245.1" "3361.6" "3167.8" "" "" "" "" "" "" "" "" "" "" "2971.0" "2677.0" "3064.9" "3287.5" "2700.3" "3242.3" "2450.3" "2866.3" "3007.9" "1130.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7462216625703255168" "False" "High" "IsMasterProtein" "O43847" "Nardilysin OS=Homo sapiens OX=9606 GN=NRDC PE=1 SV=3" "0.000" "False" "91.671" "20" "23" "33" "23" "1151" "131.6" "4.98" "122.10" "23" "protein metabolism;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00675, Pf05193, Pf16187" "4898" "ENSG00000078618" "NRDC" "A6NI41; hsa:4898; O15241; O15242; O43847; Q5VUL0; Q96HB2; Q9NU57" "" "" "0" "0" "0.980" "0.990" "0.971" "0.989" "0.960" "1.019" "0.931" "0.962" "1.314" "3210.7" "3146.3" "3179.1" "3116.7" "3176.6" "3081.3" "3270.3" "2988.9" "3088.2" "4219.6" "" "" "" "" "" "" "" "" "" "" "2886.7" "2545.9" "2875.6" "3042.3" "2621.4" "3081.3" "2448.7" "2640.0" "2763.3" "1506.3" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4459435427997336669" "False" "High" "IsMasterProtein" "O60231" "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Homo sapiens OX=9606 GN=DHX16 PE=1 SV=2" "0.000" "False" "91.640" "27" "25" "28" "24" "1041" "119.2" "6.80" "112.56" "25" "RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "8449" "ENSG00000204560; ENSG00000206486; ENSG00000226171; ENSG00000231377; ENSG00000233049; ENSG00000233418; ENSG00000233561" "DHX16" "hsa:8449; O60231; O60322; Q5JP45; Q969X7; Q96QC1" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.004" "0.997" "0.930" "1.031" "1.035" "1.016" "0.959" "1.004" "1.169" "2389.1" "2398.3" "2382.8" "2221.3" "2463.8" "2472.6" "2427.9" "2292.2" "2398.6" "2793.4" "" "" "" "" "" "" "" "" "" "" "2148.0" "1940.6" "2155.3" "2168.3" "2033.2" "2472.6" "1818.0" "2024.6" "2146.3" "997.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8472410284542291541" "False" "High" "IsMasterProtein" "P61289" "Proteasome activator complex subunit 3 OS=Homo sapiens OX=9606 GN=PSME3 PE=1 SV=1" "0.000" "False" "91.628" "56" "15" "45" "15" "254" "29.5" "5.95" "175.41" "15" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "10197" "ENSG00000131467" "PSME3" "A8K9A3; hsa:10197; O35563; P61289; P97373; Q12920; Q13172; Q9BQD9" "Proteasome degradation" "Ub-specific processing proteases; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.067" "1.104" "1.066" "1.046" "1.072" "1.063" "1.050" "1.099" "0.834" "4020.6" "4288.5" "4440.1" "4284.6" "4203.6" "4309.3" "4273.4" "4221.6" "4417.1" "3351.4" "" "" "" "" "" "" "" "" "" "" "3614.9" "3470.1" "4016.2" "4182.4" "3468.9" "4309.3" "3199.9" "3728.8" "3952.4" "1196.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2776993726351284183" "False" "High" "IsMasterProtein" "Q9BVJ6" "U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens OX=9606 GN=UTP14A PE=1 SV=1" "0.000" "False" "91.609" "28" "19" "26" "19" "771" "87.9" "7.87" "112.00" "19" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf04615" "10813" "ENSG00000156697" "UTP14A" "A8K7A3; A8MVQ1; B4DQ08; E9PEL7; hsa:10813; Q5JYF1; Q9BVJ6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.975" "0.780" "0.990" "1.046" "0.822" "1.062" "0.966" "0.776" "0.755" "2410.6" "2350.5" "1879.1" "2386.9" "2520.4" "1982.3" "2561.0" "2328.0" "1871.3" "1818.9" "" "" "" "" "" "" "" "" "" "" "2167.3" "1901.9" "1699.7" "2329.9" "2079.9" "1982.3" "1917.6" "2056.2" "1674.4" "649.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957906910240928632" "False" "High" "IsMasterProtein" "P22033" "Methylmalonyl-CoA mutase, mitochondrial OS=Homo sapiens OX=9606 GN=MMUT PE=1 SV=4" "0.000" "False" "91.537" "29" "18" "29" "18" "750" "83.1" "6.93" "114.03" "18" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01642, Pf02310" "4594" "ENSG00000146085" "MMUT" "A8K953; hsa:4594; P22033; Q5SYZ3; Q96B11; Q9UD64" "Vitamin B12 metabolism; Amino acid metabolism" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "6" "0" "1.050" "1.052" "0.989" "1.077" "1.062" "1.028" "1.047" "1.092" "0.872" "3207.2" "3367.8" "3374.4" "3172.1" "3455.3" "3405.6" "3296.2" "3358.0" "3502.0" "2795.8" "" "" "" "" "" "" "" "" "" "" "2883.6" "2725.1" "3052.2" "3096.4" "2851.4" "3405.6" "2468.1" "2966.0" "3133.5" "998.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8219779968186532826" "False" "High" "IsMasterProtein" "Q9UI26" "Importin-11 OS=Homo sapiens OX=9606 GN=IPO11 PE=1 SV=1" "0.000" "False" "91.090" "21" "18" "31" "18" "975" "112.5" "5.25" "119.13" "18" "transport" "cytosol;nucleus" "other molecular function" "Pf03810" "51194" "ENSG00000086200" "IPO11" "A6NGJ5; B4DZ73; D3DW98; hsa:51194; Q8N5R2; Q9NSJ6; Q9NVB1; Q9UI26" "" "" "0" "0" "1.041" "1.083" "0.962" "1.043" "1.008" "1.026" "1.042" "1.040" "0.912" "2602.9" "2709.8" "2819.3" "2505.0" "2714.5" "2625.0" "2669.8" "2712.3" "2706.1" "2374.5" "" "" "" "" "" "" "" "" "" "" "2340.3" "2192.7" "2550.1" "2445.2" "2240.0" "2625.0" "1999.1" "2395.7" "2421.4" "847.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669002677123591675" "False" "High" "IsMasterProtein" "P06493" "Cyclin-dependent kinase 1 OS=Homo sapiens OX=9606 GN=CDK1 PE=1 SV=3" "0.000" "False" "91.002" "67" "16" "39" "14" "297" "34.1" "8.40" "150.00" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "983" "ENSG00000170312" "CDK1" "A8K7C4; C9J497; hsa:983; O60764; P06493" "miRNA regulation of DNA damage response; Cell cycle; Microtubule cytoskeleton regulation; Spinal cord injury; Retinoblastoma gene in cancer; ATM signaling pathway; PPAR-alpha pathway; Nuclear receptors meta-pathway; TGF-beta signaling pathway; G1 to S cell cycle control; Cohesin complex - Cornelia de Lange syndrome; Urotensin-II-mediated signaling pathway; DNA damage response" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; PKR-mediated signaling; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; Ovarian tumor domain proteases; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; MAPK3 (ERK1) activation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; G1/S-Specific Transcription; Initiation of Nuclear Envelope (NE) Reformation; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes; Phosphorylation of Emi1" "50" "1" "1.012" "1.132" "1.022" "1.010" "1.106" "0.962" "1.026" "1.123" "1.244" "3896.6" "3942.4" "4409.5" "3982.2" "3935.4" "4309.2" "3746.7" "3998.6" "4375.9" "4846.2" "" "" "" "" "" "" "" "" "" "" "3503.4" "3190.1" "3988.6" "3887.2" "3247.5" "4309.2" "2805.4" "3531.9" "3915.5" "1730.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5729262198654758902" "False" "High" "IsMasterProtein" "O43396" "Thioredoxin-like protein 1 OS=Homo sapiens OX=9606 GN=TXNL1 PE=1 SV=3" "0.000" "False" "90.966" "66" "14" "47" "14" "289" "32.2" "4.96" "191.10" "14" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00085, Pf06201" "9352" "ENSG00000091164" "TXNL1" "hsa:9352; O43396" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "0.979" "0.993" "0.958" "1.008" "1.011" "0.991" "0.969" "0.984" "0.925" "4162.6" "4076.6" "4134.6" "3986.6" "4196.6" "4209.7" "4123.8" "4035.3" "4095.6" "3849.8" "" "" "" "" "" "" "" "" "" "" "3742.5" "3298.6" "3739.9" "3891.5" "3463.1" "4209.7" "3087.8" "3564.3" "3664.7" "1374.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887047081584333281" "False" "High" "IsMasterProtein" "P54652" "Heat shock-related 70 kDa protein 2 OS=Homo sapiens OX=9606 GN=HSPA2 PE=1 SV=1" "0.000" "False" "90.882" "21" "15" "107" "1" "639" "70.0" "5.74" "384.00" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00012" "3306" "ENSG00000126803" "HSPA2" "hsa:3306; P54652; Q15508; Q53XM3; Q9UE78" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection; 7q11.23 copy number variation syndrome; Urotensin-II-mediated signaling pathway" "Regulation of HSF1-mediated heat shock response; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Meiotic synapsis; PKR-mediated signaling; Attenuation phase" "10" "0" "0.951" "0.995" "0.972" "0.912" "0.819" "0.887" "0.920" "0.873" "0.772" "1081.5" "1028.1" "1076.5" "1051.5" "986.2" "885.6" "959.3" "995.0" "943.7" "834.5" "" "" "" "" "" "" "" "" "" "" "972.4" "831.9" "973.8" "1026.4" "813.8" "885.6" "718.3" "878.9" "844.4" "297.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8172346971524846949" "False" "High" "IsMasterProtein" "Q13126" "S-methyl-5'-thioadenosine phosphorylase OS=Homo sapiens OX=9606 GN=MTAP PE=1 SV=2" "0.000" "False" "90.746" "69" "14" "40" "14" "283" "31.2" "7.18" "150.61" "14" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01048" "4507" "ENSG00000099810" "MTAP" "hsa:4507; I2G7M5; I2G7M6; I2G7M7; I2G7M8; I2G7M9; I2G7N0; Q13126; Q5T3P3; Q9H010" "Methionine de novo and salvage pathway" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Methionine salvage pathway" "3" "0" "1.044" "1.032" "1.103" "1.108" "1.078" "1.072" "1.043" "1.084" "0.893" "2349.3" "2453.8" "2425.5" "2591.4" "2602.2" "2531.8" "2517.3" "2450.2" "2546.9" "2098.0" "" "" "" "" "" "" "" "" "" "" "2112.2" "1985.5" "2193.9" "2529.6" "2147.4" "2531.8" "1884.9" "2164.2" "2279.0" "748.9" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2703376622299265366" "False" "High" "IsMasterProtein" "Q9UKF6" "Cleavage and polyadenylation specificity factor subunit 3 OS=Homo sapiens OX=9606 GN=CPSF3 PE=1 SV=1" "0.000" "False" "90.398" "31" "19" "33" "19" "684" "77.4" "5.60" "117.25" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07521, Pf10996, Pf11718, Pf16661" "51692" "ENSG00000119203" "CPSF3" "hsa:51692; O14769; Q53RS2; Q96F36; Q9UKF6" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Transport of Mature mRNA Derived from an Intronless Transcript" "6" "0" "1.057" "1.020" "0.916" "1.091" "0.991" "1.007" "0.998" "1.053" "1.095" "1833.4" "1937.7" "1870.7" "1680.1" "2000.5" "1817.5" "1845.9" "1829.9" "1931.1" "2007.9" "" "" "" "" "" "" "" "" "" "" "1648.4" "1567.9" "1692.1" "1640.1" "1650.8" "1817.5" "1382.1" "1616.3" "1728.0" "716.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2260332764015544813" "False" "High" "IsMasterProtein" "Q9BTW9" "Tubulin-specific chaperone D OS=Homo sapiens OX=9606 GN=TBCD PE=1 SV=2" "0.000" "False" "90.342" "25" "24" "33" "24" "1192" "132.5" "6.19" "127.94" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12612" "6904" "ENSG00000141556" "TBCD" "hsa:6904; O95458; Q7L8K1; Q8IXP6; Q8NAX0; Q8WYH4; Q96E74; Q9BTW9; Q9UF82; Q9UG46; Q9Y2J3" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.032" "0.989" "0.921" "1.013" "0.985" "1.024" "0.980" "0.988" "0.922" "2569.7" "2651.1" "2541.0" "2366.8" "2603.1" "2531.8" "2631.2" "2518.6" "2538.9" "2369.5" "" "" "" "" "" "" "" "" "" "" "2310.4" "2145.1" "2298.4" "2310.4" "2148.1" "2531.8" "1970.2" "2224.6" "2271.8" "845.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8320203953169685442" "False" "High" "IsMasterProtein" "Q9NZL9" "Methionine adenosyltransferase 2 subunit beta OS=Homo sapiens OX=9606 GN=MAT2B PE=1 SV=1" "0.000" "False" "90.221" "53" "16" "38" "16" "334" "37.5" "7.36" "135.19" "16" "other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04321" "27430" "ENSG00000038274" "MAT2B" "B2R5Y6; hsa:27430; Q1WAI7; Q27J92; Q3LIE8; Q567T7; Q6NYC7; Q9BS89; Q9H3E1; Q9NZL9; Q9UJ54" "Trans-sulfuration pathway; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Methionine de novo and salvage pathway; Spina bifida; Methylation pathways" "Ub-specific processing proteases; Methylation" "8" "0" "1.010" "0.984" "0.940" "1.058" "0.974" "1.039" "1.006" "1.004" "0.839" "3525.5" "3560.1" "3470.4" "3315.3" "3730.1" "3434.1" "3663.2" "3547.3" "3540.5" "2957.5" "" "" "" "" "" "" "" "" "" "" "3169.8" "2880.7" "3139.1" "3236.1" "3078.1" "3434.1" "2742.9" "3133.2" "3168.0" "1055.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7835862942369075388" "False" "High" "IsMasterProtein" "P06753" "Tropomyosin alpha-3 chain OS=Homo sapiens OX=9606 GN=TPM3 PE=1 SV=2" "0.000" "False" "90.181" "45" "18" "58" "7" "285" "32.9" "4.72" "184.98" "18" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf00261" "7170" "ENSG00000143549" "TPM3" "D3DV71; hsa:7170; P06753; P12324; Q2QD06; Q5VU58; Q5VU63; Q5VU66; Q5VU71; Q5VU72; Q8TCG3; Q969Q2; Q9NQH8" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Striated muscle contraction pathway; VEGFA-VEGFR2 signaling" "RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; Smooth Muscle Contraction; Striated Muscle Contraction" "7" "0" "0.933" "0.972" "0.969" "0.927" "1.000" "0.911" "1.019" "0.885" "0.797" "2315.6" "2161.5" "2250.7" "2243.0" "2147.1" "2315.5" "2109.5" "2358.6" "2049.5" "1844.7" "" "" "" "" "" "" "" "" "" "" "2082.0" "1749.0" "2035.8" "2189.4" "1771.8" "2315.5" "1579.5" "2083.3" "1833.9" "658.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6750207652327358618" "False" "High" "IsMasterProtein" "O43719" "17S U2 SnRNP complex component HTATSF1 OS=Homo sapiens OX=9606 GN=HTATSF1 PE=1 SV=1" "0.000" "False" "89.973" "33" "25" "31" "25" "755" "85.8" "4.40" "112.69" "25" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "27336" "ENSG00000102241" "HTATSF1" "D3DWG9; hsa:27336; O43719; Q59G06; Q99730" "" "mRNA Splicing - Major Pathway" "1" "0" "1.004" "0.966" "0.970" "1.021" "0.967" "1.051" "0.948" "0.972" "3.574" "2243.4" "2251.5" "2167.8" "2176.3" "2290.4" "2168.8" "2357.5" "2126.3" "2180.6" "8016.9" "" "" "" "" "" "" "" "" "" "" "2017.1" "1821.8" "1960.8" "2124.4" "1890.1" "2168.8" "1765.2" "1878.0" "1951.1" "2861.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3104846382151978420" "False" "High" "IsMasterProtein" "Q9UKY7" "Protein CDV3 homolog OS=Homo sapiens OX=9606 GN=CDV3 PE=1 SV=1" "0.000" "False" "89.888" "37" "9" "47" "9" "258" "27.3" "6.40" "187.59" "9" "" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf15359" "55573" "ENSG00000091527" "CDV3" "B3KUC2; hsa:55573; Q96IP9; Q9UKY7" "" "" "0" "0" "0.922" "0.890" "0.957" "0.918" "0.885" "0.896" "0.992" "0.860" "0.778" "5502.9" "5072.3" "4895.8" "5265.5" "5052.3" "4871.9" "4930.4" "5461.0" "4730.4" "4282.0" "" "" "" "" "" "" "" "" "" "" "4947.6" "4104.3" "4428.4" "5139.9" "4169.3" "4871.9" "3691.7" "4823.5" "4232.7" "1528.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3253297407861631258" "False" "High" "IsMasterProtein" "O95155" "Ubiquitin conjugation factor E4 B OS=Homo sapiens OX=9606 GN=UBE4B PE=1 SV=1" "0.000" "False" "89.873" "22" "24" "31" "23" "1302" "146.1" "6.55" "109.81" "24" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "10277" "ENSG00000130939" "UBE4B" "A8K8S9; G0ZJH6; O75169; O95155; O95338; Q5SZ12; Q5SZ16; Q96QD4; Q9BYI7" "" "" "0" "0" "1.029" "0.977" "0.951" "1.046" "0.973" "0.994" "1.011" "0.963" "0.920" "2310.0" "2377.6" "2257.2" "2196.9" "2417.1" "2247.1" "2296.6" "2334.6" "2224.5" "2126.4" "" "" "" "" "" "" "" "" "" "" "2077.0" "1923.9" "2041.7" "2144.5" "1994.6" "2247.1" "1719.6" "2062.0" "1990.5" "759.0" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515792609303095651" "False" "High" "IsMasterProtein" "P61204" "ADP-ribosylation factor 3 OS=Homo sapiens OX=9606 GN=ARF3 PE=1 SV=2" "0.000" "False" "89.735" "67" "12" "59" "6" "181" "20.6" "7.43" "224.04" "12" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "377" "ENSG00000134287" "ARF3" "A8K6G8; B7ZB63; hsa:377; P16587; P61204" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Synthesis of PIPs at the Golgi membrane" "3" "6" "1.030" "1.075" "1.022" "1.122" "1.004" "1.007" "0.966" "1.094" "0.792" "5403.5" "5567.9" "5810.3" "5523.2" "6061.9" "5426.7" "5442.6" "5217.3" "5909.0" "4279.4" "" "" "" "" "" "" "" "" "" "" "4858.2" "4505.4" "5255.6" "5391.4" "5002.4" "5426.7" "4075.3" "4608.3" "5287.3" "1527.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-61842363996650095" "False" "High" "IsMasterProtein" "P19623" "Spermidine synthase OS=Homo sapiens OX=9606 GN=SRM PE=1 SV=1" "0.000" "False" "89.687" "60" "12" "29" "12" "302" "33.8" "5.49" "135.39" "12" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01564, Pf17284" "6723" "ENSG00000116649" "SRM" "B1AKP9; hsa:6723; P19623; Q15511" "Methionine de novo and salvage pathway; Amino acid metabolism" "Metabolism of polyamines" "3" "0" "0.930" "0.869" "0.968" "0.904" "0.843" "1.031" "0.869" "0.860" "1.384" "2049.0" "1904.7" "1780.9" "1982.4" "1852.1" "1728.0" "2111.5" "1781.0" "1761.8" "2835.5" "" "" "" "" "" "" "" "" "" "" "1842.2" "1541.2" "1610.9" "1935.1" "1528.4" "1728.0" "1581.1" "1573.1" "1576.5" "1012.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900163226744829744" "False" "High" "IsMasterProtein" "Q99590" "Protein SCAF11 OS=Homo sapiens OX=9606 GN=SCAF11 PE=1 SV=2" "0.000" "False" "89.684" "18" "21" "28" "21" "1463" "164.6" "8.41" "113.80" "21" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf13639" "9169" "ENSG00000139218" "SCAF11" "A6NEU9; A6NLW5; hsa:9169; Q8IW59; Q99590" "Apoptosis" "" "1" "0" "1.025" "1.037" "0.993" "1.055" "1.135" "1.011" "0.997" "0.977" "0.900" "2359.6" "2418.5" "2446.1" "2344.2" "2490.0" "2678.7" "2384.6" "2351.3" "2305.2" "2124.0" "" "" "" "" "" "" "" "" "" "" "2121.5" "1957.0" "2212.6" "2288.2" "2054.8" "2678.7" "1785.5" "2076.8" "2062.6" "758.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320605404870657198" "False" "High" "IsMasterProtein" "Q8NC51" "SERPINE1 mRNA-binding protein 1 OS=Homo sapiens OX=9606 GN=SERBP1 PE=1 SV=2" "0.000" "False" "89.478" "42" "16" "41" "16" "408" "44.9" "8.65" "152.75" "16" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04774, Pf16174" "26135" "ENSG00000142864" "SERBP1" "hsa:26135; Q5VU19; Q5VU20; Q5VU22; Q8NC51; Q8WUH0; Q96SE2; Q9BTY3; Q9BUM4; Q9Y367; Q9Y4S3" "Apoptosis-related network due to altered Notch3 in ovarian cancer" "" "1" "0" "1.024" "1.128" "0.943" "1.136" "1.245" "1.021" "1.074" "1.041" "0.989" "4203.9" "4305.7" "4740.1" "3964.5" "4776.4" "5234.5" "4292.8" "4513.3" "4377.2" "4156.9" "" "" "" "" "" "" "" "" "" "" "3779.7" "3484.0" "4287.6" "3869.9" "3941.6" "5234.5" "3214.3" "3986.5" "3916.6" "1483.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "240711896831941506" "False" "High" "IsMasterProtein" "P23396" "Small ribosomal subunit protein uS3 OS=Homo sapiens OX=9606 GN=RPS3 PE=1 SV=2" "0.000" "False" "89.465" "80" "18" "43" "18" "243" "26.7" "9.66" "144.67" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00189, Pf07650" "6188" "ENSG00000149273" "RPS3" "B2R7N5; hsa:6188; J3KN86; P23396; Q498B5; Q8NI95" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.955" "1.006" "0.872" "0.932" "0.992" "0.940" "0.825" "1.016" "1.249" "3001.6" "2865.4" "3018.9" "2617.6" "2797.4" "2977.1" "2822.2" "2477.2" "3048.5" "3749.1" "" "" "" "" "" "" "" "" "" "" "2698.7" "2318.6" "2730.7" "2555.1" "2308.4" "2977.1" "2113.2" "2188.1" "2727.7" "1338.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8217852517475646555" "False" "High" "IsMasterProtein" "Q9H3U1" "Protein unc-45 homolog A OS=Homo sapiens OX=9606 GN=UNC45A PE=1 SV=1" "0.000" "False" "89.400" "28" "22" "31" "22" "944" "103.0" "6.07" "116.61" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf11701, Pf13181" "55898" "ENSG00000140553" "UNC45A" "A8K6F7; hsa:55898; Q7L3Y6; Q9H3U1; Q9H3U8; Q9NSE8; Q9NSE9" "" "" "0" "0" "1.017" "1.049" "0.968" "1.011" "1.044" "1.017" "0.991" "1.048" "2.010" "2639.4" "2685.2" "2768.0" "2554.7" "2669.1" "2755.3" "2683.0" "2616.8" "2767.0" "5304.4" "" "" "" "" "" "" "" "" "" "" "2373.1" "2172.8" "2503.7" "2493.8" "2202.6" "2755.3" "2009.0" "2311.3" "2475.8" "1893.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-629472087456424791" "False" "High" "IsMasterProtein" "Q09472" "Histone acetyltransferase p300 OS=Homo sapiens OX=9606 GN=EP300 PE=1 SV=2" "0.000" "False" "89.236" "11" "25" "35" "15" "2414" "264.0" "8.50" "121.47" "25" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "2033" "ENSG00000100393" "EP300" "B1AKC2; hsa:2033; Q09472" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; IL-4 signaling pathway; Wnt signaling pathway and pluripotency; Prion disease pathway; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; CAMKK2 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; CCL18 signaling pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; Urotensin-II-mediated signaling pathway; Pathophysiological roles of DUX4 in FSHD1; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "HATs acetylate histones; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis; CD209 (DC-SIGN) signaling; Metalloprotease DUBs; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NGF-stimulated transcription; Heme signaling; Regulation of RUNX3 expression and activity; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; SUMOylation of transcription cofactors; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Methylation; NFE2L2 regulating anti-oxidant/detoxification enzymes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; NOTCH1 Intracellular Domain Regulates Transcription; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling; NFE2L2 regulating MDR associated enzymes; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; NOTCH3 Intracellular Domain Regulates Transcription; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; Polo-like kinase mediated events; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; RUNX3 regulates p14-ARF; Regulation of gene expression by Hypoxia-inducible Factor; PI5P Regulates TP53 Acetylation; NOTCH2 intracellular domain regulates transcription; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "91" "9" "1.016" "0.975" "1.002" "1.048" "0.965" "1.025" "1.018" "0.971" "0.995" "2415.2" "2454.4" "2354.3" "2420.6" "2530.5" "2331.1" "2476.0" "2458.5" "2346.1" "2404.0" "" "" "" "" "" "" "" "" "" "" "2171.5" "1986.0" "2129.6" "2362.8" "2088.2" "2331.1" "1853.9" "2171.5" "2099.3" "858.1" "20" "20" "20" "20" "20" "20" "20" "20" "20" "20" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8046944082778510554" "False" "High" "IsMasterProtein" "P32119" "Peroxiredoxin-2 OS=Homo sapiens OX=9606 GN=PRDX2 PE=1 SV=5" "0.000" "False" "89.038" "55" "14" "70" "13" "198" "21.9" "5.97" "277.80" "14" "cell cycle OR cell proliferation;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00578, Pf10417" "7001" "ENSG00000167815" "PRDX2" "A8K0C0; hsa:7001; P31945; P32118; P32119; P35701; Q6FHG4; Q92763; Q9UC23" "Selenium micronutrient network; VEGFA-VEGFR2 signaling; HDAC6 interactions in the central nervous system" "Detoxification of Reactive Oxygen Species; TP53 Regulates Metabolic Genes; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "6" "0" "1.017" "1.031" "1.057" "0.991" "0.980" "0.968" "1.012" "1.013" "0.782" "6460.9" "6573.7" "6658.0" "6827.6" "6399.7" "6331.4" "6255.4" "6536.0" "6546.8" "5053.3" "" "" "" "" "" "" "" "" "" "" "5809.0" "5319.2" "6022.4" "6664.7" "5281.1" "6331.4" "4683.9" "5773.0" "5858.0" "1803.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3957617844882623254" "False" "High" "IsMasterProtein" "Q7Z3B4" "Nucleoporin p54 OS=Homo sapiens OX=9606 GN=NUP54 PE=1 SV=2" "0.000" "False" "88.925" "49" "21" "34" "21" "507" "55.4" "7.02" "121.89" "21" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13874, Pf18437" "53371" "ENSG00000138750" "NUP54" "B2RCK7; B4DT35; hsa:53371; Q7Z3B4; Q96EA7; Q9NVL5; Q9P0I1" "" "Regulation of HSF1-mediated heat shock response; snRNP Assembly; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.093" "1.041" "1.060" "1.052" "1.025" "1.061" "1.029" "1.030" "1.047" "2118.8" "2316.7" "2204.9" "2246.0" "2229.0" "2171.1" "2248.2" "2179.7" "2183.4" "2218.6" "" "" "" "" "" "" "" "" "" "" "1905.0" "1874.6" "1994.4" "2192.4" "1839.4" "2171.1" "1683.4" "1925.3" "1953.6" "792.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1288043512151873046" "False" "High" "IsMasterProtein" "Q8WU39" "Marginal zone B- and B1-cell-specific protein OS=Homo sapiens OX=9606 GN=MZB1 PE=1 SV=1" "0.000" "False" "88.904" "66" "7" "39" "7" "189" "20.7" "5.57" "183.05" "7" "cell organization and biogenesis;other biological processes" "non-structural extracellular;ER/Golgi;other cell component" "" "Pf11938" "51237" "ENSG00000170476" "MZB1" "D2IYS0; hsa:51237; Q7Z6N2; Q8WU39; Q96RL5; Q9P0T3" "" "" "0" "0" "0.962" "0.976" "0.976" "1.034" "0.997" "1.006" "1.083" "0.992" "0.813" "2057.0" "1978.5" "2007.4" "2007.6" "2126.8" "2051.7" "2069.1" "2228.5" "2041.0" "1672.1" "" "" "" "" "" "" "" "" "" "" "1849.4" "1600.9" "1815.8" "1959.7" "1755.1" "2051.7" "1549.3" "1968.3" "1826.3" "596.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8415712224574136193" "False" "High" "IsMasterProtein" "P26196" "Probable ATP-dependent RNA helicase DDX6 OS=Homo sapiens OX=9606 GN=DDX6 PE=1 SV=2" "0.000" "False" "88.829" "43" "16" "34" "16" "483" "54.4" "8.66" "137.97" "16" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1656" "ENSG00000110367" "DDX6" "hsa:1656; P26196; Q5D048" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.044" "1.044" "1.061" "1.047" "1.007" "1.069" "1.007" "1.000" "0.961" "3047.1" "3180.3" "3181.5" "3231.6" "3190.0" "3068.8" "3256.8" "3069.9" "3045.7" "2929.7" "" "" "" "" "" "" "" "" "" "" "2739.6" "2573.4" "2877.8" "3154.5" "2632.5" "3068.8" "2438.6" "2711.5" "2725.3" "1045.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8333902830713908614" "False" "High" "IsMasterProtein" "P05388" "Large ribosomal subunit protein uL10 OS=Homo sapiens OX=9606 GN=RPLP0 PE=1 SV=1" "0.000" "False" "88.716" "45" "13" "39" "13" "317" "34.3" "5.97" "155.45" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00428, Pf00466, Pf17777" "6175" "ENSG00000089157" "RPLP0" "hsa:6175; P05388; Q3B7A4; Q9BVK4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.134" "1.013" "0.990" "1.255" "1.071" "1.034" "1.265" "1.036" "0.581" "3865.5" "4383.3" "3917.2" "3827.6" "4851.5" "4141.6" "3998.4" "4888.7" "4004.6" "2246.5" "" "" "" "" "" "" "" "" "" "" "3475.4" "3546.8" "3543.3" "3736.3" "4003.5" "4141.6" "2993.9" "4318.0" "3583.3" "801.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5301300435928167882" "False" "High" "IsMasterProtein" "P47755" "F-actin-capping protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=CAPZA2 PE=1 SV=3" "0.000" "False" "88.636" "58" "11" "34" "9" "286" "32.9" "5.85" "160.23" "11" "cell organization and biogenesis" "non-structural extracellular;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf01267" "830" "ENSG00000198898" "CAPZA2" "B4DG50; hsa:830; P47755" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Sensory processing of sound by inner hair cells of the cochlea; Factors involved in megakaryocyte development and platelet production; Advanced glycosylation endproduct receptor signaling" "7" "2" "1.011" "1.004" "0.981" "1.034" "0.981" "0.968" "0.937" "1.002" "0.865" "2515.8" "2544.4" "2525.9" "2468.4" "2600.1" "2467.2" "2436.0" "2358.1" "2521.7" "2176.0" "" "" "" "" "" "" "" "" "" "" "2261.9" "2058.8" "2284.7" "2409.5" "2145.6" "2467.2" "1824.0" "2082.8" "2256.4" "776.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8724268624419382152" "False" "High" "IsMasterProtein" "P50213" "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3A PE=1 SV=1" "0.000" "False" "88.566" "46" "15" "42" "15" "366" "39.6" "6.92" "151.75" "15" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3419" "ENSG00000166411" "IDH3A" "D3DW83; hsa:3419; P50213; Q9H3X0" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Metabolic reprogramming in colon cancer; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein degradation" "5" "0" "1.025" "0.989" "1.027" "0.997" "1.023" "1.034" "1.060" "1.075" "0.798" "4435.8" "4547.2" "4388.0" "4556.2" "4424.5" "4538.9" "4585.1" "4702.5" "4769.4" "3540.2" "" "" "" "" "" "" "" "" "" "" "3988.3" "3679.5" "3969.1" "4447.5" "3651.2" "4538.9" "3433.2" "4153.6" "4267.7" "1263.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7160695848866474340" "False" "High" "IsMasterProtein" "Q96JG6" "Syndetin OS=Homo sapiens OX=9606 GN=VPS50 PE=1 SV=3" "0.000" "False" "88.549" "24" "20" "27" "20" "964" "111.1" "6.20" "104.96" "20" "transport" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf10474, Pf10475" "55610" "ENSG00000004766" "VPS50" "B3KX22; D1MQ00; F5H5U7; hsa:55610; Q75N07; Q8WVK3; Q96JG6; Q9H5C6" "" "" "0" "0" "1.006" "0.963" "0.962" "1.013" "0.935" "1.034" "0.980" "0.953" "1.092" "1732.3" "1742.1" "1668.3" "1667.2" "1755.6" "1619.9" "1790.4" "1697.9" "1650.2" "1891.0" "" "" "" "" "" "" "" "" "" "" "1557.5" "1409.7" "1509.0" "1627.4" "1448.8" "1619.9" "1340.6" "1499.7" "1476.6" "675.0" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-374289036912732411" "False" "High" "IsMasterProtein" "Q15042" "Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens OX=9606 GN=RAB3GAP1 PE=1 SV=3" "0.000" "False" "88.436" "22" "19" "26" "19" "981" "110.5" "5.55" "97.37" "19" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf13890, Pf19533" "22930" "ENSG00000115839" "RAB3GAP1" "A6H8Z3; C9J837; hsa:22930; Q15042; Q659F5; Q8TBB4" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.036" "0.978" "0.939" "1.016" "0.949" "1.016" "0.961" "0.962" "1.788" "2491.8" "2580.6" "2436.5" "2339.3" "2532.0" "2364.5" "2532.1" "2394.1" "2398.0" "4454.8" "" "" "" "" "" "" "" "" "" "" "2240.4" "2088.1" "2203.9" "2283.5" "2089.4" "2364.5" "1896.0" "2114.6" "2145.7" "1590.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4683582367495080514" "False" "High" "IsMasterProtein" "Q6IA86" "Elongator complex protein 2 OS=Homo sapiens OX=9606 GN=ELP2 PE=1 SV=2" "0.000" "False" "88.361" "27" "18" "28" "18" "826" "92.4" "5.96" "119.04" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55250" "ENSG00000134759" "ELP2" "A8KAI6; B4DTG0; B4DXP0; E7EP23; E9PCX0; Q53GZ0; Q687Y8; Q6IA86; Q8N5C2; Q96GV4; Q96PI7; Q9H9N0; Q9NV81" "" "HATs acetylate histones" "1" "0" "1.065" "1.023" "0.959" "1.086" "0.994" "1.046" "0.981" "1.060" "0.898" "2894.1" "3082.5" "2961.4" "2775.4" "3141.9" "2875.7" "3026.6" "2838.0" "3068.5" "2597.9" "" "" "" "" "" "" "" "" "" "" "2602.1" "2494.2" "2678.7" "2709.2" "2592.7" "2875.7" "2266.2" "2506.7" "2745.6" "927.4" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3099345167640791747" "False" "High" "IsMasterProtein" "Q00796" "Sorbitol dehydrogenase OS=Homo sapiens OX=9606 GN=SORD PE=1 SV=4" "0.000" "False" "88.279" "50" "15" "36" "15" "357" "38.3" "7.97" "147.06" "15" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf00107, Pf08240" "6652" "ENSG00000140263" "SORD" "B2R655; B7Z3A6; hsa:6652; J3JZZ5; Q00796; Q16682; Q9UMD6" "Disorders of fructose metabolism; Polyol pathway" "Formation of xylulose-5-phosphate; Fructose biosynthesis" "4" "0" "1.013" "0.960" "1.037" "0.995" "0.977" "0.976" "0.975" "0.994" "0.815" "3834.5" "3886.0" "3680.9" "3977.1" "3817.1" "3744.6" "3744.3" "3737.4" "3811.2" "3124.7" "" "" "" "" "" "" "" "" "" "" "3447.6" "3144.4" "3329.5" "3882.2" "3150.0" "3744.6" "2803.6" "3301.1" "3410.3" "1115.4" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3819928772784180698" "False" "High" "IsMasterProtein" "Q03001" "Dystonin OS=Homo sapiens OX=9606 GN=DST PE=1 SV=4" "0.000" "False" "88.266" "4" "31" "32" "27" "7570" "860.1" "5.25" "104.61" "31" "cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf00681, Pf02187, Pf13499, Pf17902, Pf18373, Pf21019, Pf21020, Pf21097" "667" "ENSG00000151914" "DST" "B7Z3H1; E7ERU0; hsa:667; O94833; Q03001; Q12825; Q13266; Q13267; Q13775; Q5TBT0; Q5TBT2; Q5TF23; Q5TF24; Q8N1T8; Q8N8J3; Q8WXK8; Q8WXK9; Q96AK9; Q96DQ5; Q96J76; Q96QT5; Q9H555; Q9UGD7; Q9UGD8; Q9UN10" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Type I hemidesmosome assembly" "6" "0" "1.013" "0.971" "0.958" "1.005" "0.944" "0.977" "0.987" "0.953" "1.267" "1559.0" "1578.8" "1514.1" "1494.3" "1566.5" "1471.8" "1522.4" "1539.4" "1486.1" "1975.3" "" "" "" "" "" "" "" "" "" "" "1401.7" "1277.5" "1369.6" "1458.6" "1292.7" "1471.8" "1140.0" "1359.7" "1329.7" "705.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838568104168178339" "False" "High" "IsMasterProtein" "Q8TBC4" "NEDD8-activating enzyme E1 catalytic subunit OS=Homo sapiens OX=9606 GN=UBA3 PE=1 SV=2" "0.000" "False" "88.211" "46" "17" "30" "17" "463" "51.8" "5.45" "115.50" "17" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00899, Pf08825" "9039" "ENSG00000144744" "UBA3" "A6NLB5; A8K027; hsa:9039; O76088; Q8TBC4; Q9NTU3" "Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation" "5" "0" "0.970" "0.922" "0.958" "1.011" "0.903" "1.027" "0.924" "0.889" "1.035" "2252.0" "2185.4" "2076.9" "2157.4" "2276.6" "2033.5" "2312.1" "2081.6" "2001.1" "2330.4" "" "" "" "" "" "" "" "" "" "" "2024.7" "1768.3" "1878.6" "2106.0" "1878.7" "2033.5" "1731.2" "1838.6" "1790.6" "831.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521793610303513807" "False" "High" "IsMasterProtein" "P52789" "Hexokinase-2 OS=Homo sapiens OX=9606 GN=HK2 PE=1 SV=2" "0.000" "False" "88.091" "26" "21" "31" "18" "917" "102.3" "6.05" "110.66" "21" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00349, Pf03727" "3099" "ENSG00000159399" "HK2" "D6W5J2; hsa:3099; P52789; Q8WU87; Q9UN82" "Clear cell renal cell carcinoma pathways; Warburg effect modulated by deubiquitinating enzymes and their substrates; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; UDP-derived sugars synthesis in fibroblasts" "Glycolysis" "7" "0" "1.067" "1.004" "0.995" "1.062" "1.053" "1.019" "1.010" "1.105" "2.393" "1799.3" "1920.0" "1806.3" "1790.1" "1910.3" "1894.8" "1833.6" "1818.0" "1988.6" "4305.3" "" "" "" "" "" "" "" "" "" "" "1617.7" "1553.6" "1633.8" "1747.4" "1576.4" "1894.8" "1372.9" "1605.8" "1779.4" "1536.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8390687985957490189" "False" "High" "IsMasterProtein" "Q5VTR2" "E3 ubiquitin-protein ligase BRE1A OS=Homo sapiens OX=9606 GN=RNF20 PE=1 SV=2" "0.000" "False" "87.861" "24" "23" "28" "22" "975" "113.6" "5.94" "106.51" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "56254" "ENSG00000155827" "RNF20" "A7MCT5; hsa:56254; Q2TB34; Q5VTR2; Q69YL5; Q6P527; Q8N3J4; Q96JD3; Q9H9Y7; Q9HA51; Q9NUR4; Q9NWQ3; Q9NX83" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins; RHOBTB1 GTPase cycle" "3" "1" "0.966" "1.053" "0.927" "1.080" "1.067" "1.035" "1.019" "1.057" "2.430" "1588.2" "1534.2" "1671.8" "1472.2" "1714.9" "1694.2" "1644.4" "1619.1" "1678.6" "3859.8" "" "" "" "" "" "" "" "" "" "" "1427.9" "1241.4" "1512.2" "1437.1" "1415.1" "1694.2" "1231.3" "1430.1" "1502.0" "1377.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133999276561542569" "False" "High" "IsMasterProtein" "Q86X55" "Histone-arginine methyltransferase CARM1 OS=Homo sapiens OX=9606 GN=CARM1 PE=1 SV=3" "0.000" "False" "87.852" "28" "16" "40" "16" "608" "65.8" "6.73" "135.66" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06325, Pf11531" "10498" "ENSG00000142453" "CARM1" "A6NN38; hsa:10498; Q86X55" "Androgen receptor signaling pathway; Nitric oxide metabolism in cystic fibrosis" "Estrogen-dependent gene expression; RMTs methylate histone arginines; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; RORA activates gene expression" "15" "0" "0.994" "0.980" "0.978" "1.015" "0.936" "1.004" "0.961" "0.995" "0.763" "3327.2" "3306.6" "3261.6" "3254.9" "3376.9" "3115.8" "3341.3" "3197.8" "3311.5" "2538.1" "" "" "" "" "" "" "" "" "" "" "2991.5" "2675.6" "2950.2" "3177.3" "2786.7" "3115.8" "2501.9" "2824.5" "2963.1" "906.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5518628090009250384" "False" "High" "IsMasterProtein" "Q3V6T2" "Girdin OS=Homo sapiens OX=9606 GN=CCDC88A PE=1 SV=2" "0.000" "False" "87.851" "14" "25" "30" "25" "1871" "215.9" "6.21" "102.11" "25" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "55704" "ENSG00000115355" "CCDC88A" "A1IGE7; B7ZM78; C9JG83; hsa:55704; Q3V6T2; Q53SF1; Q581G3; Q5HYD0; Q7Z339; Q7Z3C5" "Mesodermal commitment pathway" "RND3 GTPase cycle; RND1 GTPase cycle" "3" "0" "1.000" "1.006" "1.006" "1.041" "1.001" "1.055" "1.031" "0.998" "1.441" "2164.5" "2164.9" "2176.6" "2176.7" "2252.2" "2165.9" "2282.8" "2232.2" "2160.9" "3118.0" "" "" "" "" "" "" "" "" "" "" "1946.1" "1751.7" "1968.8" "2124.8" "1858.6" "2165.9" "1709.3" "1971.6" "1933.6" "1113.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6598258105920115633" "False" "High" "IsMasterProtein" "Q5TDH0" "Protein DDI1 homolog 2 OS=Homo sapiens OX=9606 GN=DDI2 PE=1 SV=1" "0.000" "False" "87.849" "58" "15" "28" "15" "399" "44.5" "5.05" "120.15" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf09668" "84301" "ENSG00000197312" "DDI2" "A8KAE1; hsa:84301; Q5TDH0; Q7RTZ0; Q9BRT1" "" "" "0" "0" "1.002" "1.013" "1.032" "1.046" "0.981" "0.989" "1.011" "1.005" "0.904" "2287.6" "2291.9" "2318.3" "2361.7" "2393.6" "2243.7" "2261.8" "2312.4" "2300.1" "2069.1" "" "" "" "" "" "" "" "" "" "" "2056.8" "1854.5" "2097.0" "2305.3" "1975.2" "2243.7" "1693.6" "2042.5" "2058.1" "738.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-242309002880936469" "False" "High" "IsMasterProtein" "Q8NI27" "THO complex subunit 2 OS=Homo sapiens OX=9606 GN=THOC2 PE=1 SV=2" "0.000" "False" "87.818" "16" "26" "34" "26" "1593" "182.7" "8.44" "116.31" "26" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11262, Pf11732, Pf16134" "57187" "ENSG00000125676" "THOC2" "A6NM50; hsa:57187; Q5JZ12; Q6IN92; Q8NI27; Q9H8I6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.016" "0.980" "0.957" "0.942" "0.932" "1.037" "0.946" "0.915" "1.328" "2485.9" "2526.0" "2437.3" "2378.0" "2342.6" "2317.2" "2577.9" "2351.9" "2275.2" "3302.2" "" "" "" "" "" "" "" "" "" "" "2235.1" "2044.0" "2204.6" "2321.2" "1933.1" "2317.2" "1930.3" "2077.4" "2035.8" "1178.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1136415192925944721" "False" "High" "IsMasterProtein" "Q04864" "Proto-oncogene c-Rel OS=Homo sapiens OX=9606 GN=REL PE=1 SV=1" "0.000" "False" "87.731" "37" "19" "32" "19" "619" "68.5" "5.86" "132.49" "19" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5966" "ENSG00000162924" "REL" "hsa:5966; Q04864; Q17RU2; Q2PNZ7; Q6LDY0" "IL-1 signaling pathway; Leptin signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Photodynamic therapy-induced NF-kB survival signaling; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; miRNA role in immune response in sepsis; Canonical NF-kB pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways; T-cell receptor signaling pathway" "Activation of NF-kappaB in B cells" "20" "0" "1.027" "0.940" "1.006" "1.028" "0.925" "1.013" "0.952" "0.900" "1.786" "2115.4" "2173.2" "1988.8" "2127.8" "2174.0" "1957.7" "2142.2" "2013.8" "1903.9" "3777.5" "" "" "" "" "" "" "" "" "" "" "1901.9" "1758.5" "1798.9" "2077.1" "1794.0" "1957.7" "1604.0" "1778.8" "1703.6" "1348.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8004592446864816783" "False" "High" "IsMasterProtein" "O75688" "Protein phosphatase 1B OS=Homo sapiens OX=9606 GN=PPM1B PE=1 SV=1" "0.000" "False" "87.717" "40" "15" "28" "13" "479" "52.6" "5.05" "122.13" "15" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5495" "ENSG00000138032" "PPM1B" "hsa:5495; O75688; Q461Q2; Q4J6C1; Q4J6C2; Q658R4; Q96ER6; Q9HAY8" "MAPK signaling pathway" "ISG15 antiviral mechanism; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "2" "0.993" "0.982" "1.031" "1.021" "0.990" "0.998" "1.004" "0.978" "0.862" "2446.0" "2428.5" "2401.8" "2521.6" "2496.3" "2421.8" "2441.5" "2456.9" "2391.0" "2108.7" "" "" "" "" "" "" "" "" "" "" "2199.2" "1965.1" "2172.5" "2461.5" "2060.0" "2421.8" "1828.1" "2170.1" "2139.5" "752.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3668121595413898342" "False" "High" "IsMasterProtein" "Q96D46" "60S ribosomal export protein NMD3 OS=Homo sapiens OX=9606 GN=NMD3 PE=1 SV=1" "0.000" "False" "87.691" "40" "17" "24" "17" "503" "57.6" "7.14" "97.08" "17" "transport;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04981, Pf21192, Pf21193" "51068" "ENSG00000169251" "NMD3" "D3DNM7; hsa:51068; Q96D46; Q9Y2Z6" "" "" "0" "0" "0.934" "0.992" "0.949" "0.974" "0.969" "0.973" "0.975" "1.013" "0.942" "2467.5" "2304.0" "2447.5" "2341.9" "2403.7" "2391.1" "2401.2" "2404.9" "2498.9" "2323.6" "" "" "" "" "" "" "" "" "" "" "2218.5" "1864.3" "2213.9" "2286.0" "1983.5" "2391.1" "1797.9" "2124.2" "2236.0" "829.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1852807762900550805" "False" "High" "IsMasterProtein" "P28070" "Proteasome subunit beta type-4 OS=Homo sapiens OX=9606 GN=PSMB4 PE=1 SV=4" "0.000" "False" "87.676" "48" "8" "33" "8" "264" "29.2" "5.97" "140.41" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5692" "ENSG00000159377" "PSMB4" "B2R9L3; hsa:5692; P28070; P31148; Q5SZS5; Q6IBI4; Q969L6" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Regulation of expression of SLITs and ROBOs; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.043" "1.007" "1.050" "1.057" "0.940" "1.019" "0.956" "1.065" "0.815" "2380.7" "2482.6" "2397.4" "2499.8" "2517.0" "2237.1" "2426.4" "2275.2" "2536.6" "1941.2" "" "" "" "" "" "" "" "" "" "" "2140.5" "2008.8" "2168.5" "2440.1" "2077.1" "2237.1" "1816.8" "2009.6" "2269.7" "693.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3731678403857668842" "False" "High" "IsMasterProtein" "P10768" "S-formylglutathione hydrolase OS=Homo sapiens OX=9606 GN=ESD PE=1 SV=2" "0.000" "False" "87.650" "70" "13" "45" "13" "282" "31.4" "7.02" "187.78" "13" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00756" "2098" "ENSG00000139684" "ESD" "hsa:2098; P10768; Q5TBU8; Q5TBV0; Q5TBV2; Q9BVJ2" "Phase I biotransformations, non-P450" "Glutathione conjugation" "2" "0" "1.009" "1.029" "0.991" "1.034" "0.976" "0.984" "1.006" "1.027" "0.784" "3665.2" "3699.4" "3770.4" "3632.0" "3790.7" "3578.5" "3606.6" "3688.2" "3765.7" "2874.7" "" "" "" "" "" "" "" "" "" "" "3295.4" "2993.4" "3410.4" "3545.4" "3128.2" "3578.5" "2700.5" "3257.6" "3369.5" "1026.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5810129024139572187" "False" "High" "IsMasterProtein" "P34931" "Heat shock 70 kDa protein 1-like OS=Homo sapiens OX=9606 GN=HSPA1L PE=1 SV=2" "0.000" "False" "87.541" "25" "13" "74" "1" "641" "70.3" "6.02" "276.40" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00012" "3305" "ENSG00000204390; ENSG00000206383; ENSG00000234258; ENSG00000236251" "HSPA1L" "A6NNB0; B0UXW8; hsa:3305; O75634; P34931; Q2HXR3; Q8NE72; Q96QC9; Q9UQM1" "Parkin-ubiquitin proteasomal system pathway; MAPK signaling pathway; Measles virus infection" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; PKR-mediated signaling; Regulation of HSF1-mediated heat shock response; Attenuation phase" "8" "0" "0.977" "0.969" "0.963" "0.922" "1.070" "0.869" "0.899" "0.996" "0.707" "278.5" "272.1" "269.8" "268.2" "256.7" "297.9" "241.9" "250.3" "277.4" "196.8" "" "" "" "" "" "" "" "" "" "" "250.4" "220.2" "244.0" "261.8" "211.8" "297.9" "181.2" "221.1" "248.3" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4879961638611313513" "False" "High" "IsMasterProtein" "Q12765" "Secernin-1 OS=Homo sapiens OX=9606 GN=SCRN1 PE=1 SV=2" "0.000" "False" "87.484" "34" "12" "36" "12" "414" "46.4" "4.75" "128.86" "12" "protein metabolism;transport;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03577" "9805" "ENSG00000136193" "SCRN1" "A8K0E9; B4DHM0; B4DIP5; C9JPG0; hsa:9805; Q12765; Q25QX7; Q8IWD1" "" "" "0" "0" "0.923" "0.906" "0.978" "0.968" "0.897" "0.955" "0.982" "0.918" "0.820" "2386.2" "2201.7" "2162.5" "2334.7" "2309.2" "2139.7" "2278.0" "2343.1" "2189.8" "1956.1" "" "" "" "" "" "" "" "" "" "" "2145.4" "1781.6" "1956.1" "2279.0" "1905.6" "2139.7" "1705.7" "2069.6" "1959.4" "698.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3504989653461023373" "False" "High" "IsMasterProtein" "P51570" "Galactokinase OS=Homo sapiens OX=9606 GN=GALK1 PE=1 SV=1" "0.000" "False" "87.481" "38" "13" "31" "13" "392" "42.2" "6.46" "131.55" "13" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2584" "ENSG00000108479" "GALK1" "B2RC07; B4E1G6; hsa:2584; P51570" "Disorders of galactose metabolism" "Galactose catabolism; Defective GALK1 causes GALCT2" "3" "0" "1.004" "1.016" "1.089" "1.038" "1.065" "1.045" "1.037" "1.031" "0.896" "1628.1" "1635.0" "1653.5" "1773.1" "1689.7" "1734.2" "1701.1" "1687.9" "1678.5" "1458.6" "" "" "" "" "" "" "" "" "" "" "1463.8" "1323.0" "1495.6" "1730.8" "1394.4" "1734.2" "1273.7" "1490.9" "1501.9" "520.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7598274604461767952" "False" "High" "IsMasterProtein" "P49750" "YLP motif-containing protein 1 OS=Homo sapiens OX=9606 GN=YLPM1 PE=1 SV=4" "0.000" "False" "87.275" "13" "26" "32" "25" "2146" "241.5" "6.55" "112.28" "26" "other biological processes" "nucleus" "" "Pf13671" "56252" "ENSG00000119596" "YLPM1" "hsa:56252; P49750; P49752; Q96I64; Q9P1V7" "" "" "0" "1" "0.992" "1.022" "1.051" "1.046" "1.043" "1.088" "1.029" "0.967" "1.040" "2526.4" "2506.5" "2581.1" "2656.0" "2643.2" "2633.9" "2749.4" "2600.0" "2442.0" "2627.8" "" "" "" "" "" "" "" "" "" "" "2271.5" "2028.2" "2334.7" "2592.7" "2181.2" "2633.9" "2058.7" "2296.5" "2185.1" "938.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321925279742634811" "False" "High" "IsMasterProtein" "Q9Y6Y8" "SEC23-interacting protein OS=Homo sapiens OX=9606 GN=SEC23IP PE=1 SV=1" "0.000" "False" "87.269" "24" "23" "34" "23" "1000" "111.0" "5.54" "113.55" "23" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "11196" "ENSG00000107651" "SEC23IP" "D3DRD2; hsa:11196; Q8IXH5; Q9BUK5; Q9Y6Y8" "" "COPII-mediated vesicle transport" "1" "0" "1.011" "1.002" "0.984" "0.989" "0.946" "1.016" "0.981" "0.957" "1.411" "3391.3" "3430.3" "3396.8" "3337.6" "3355.0" "3208.5" "3445.0" "3325.3" "3244.2" "4785.7" "" "" "" "" "" "" "" "" "" "" "3049.1" "2775.7" "3072.5" "3258.0" "2768.6" "3208.5" "2579.5" "2937.1" "2902.9" "1708.3" "23" "23" "23" "23" "23" "23" "23" "23" "23" "23" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2257664793413269493" "False" "High" "IsMasterProtein" "Q69YN2" "CWF19-like protein 1 OS=Homo sapiens OX=9606 GN=CWF19L1 PE=1 SV=2" "0.000" "False" "87.267" "43" "18" "29" "18" "538" "60.6" "7.24" "116.25" "18" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity" "Pf04676, Pf04677" "55280" "ENSG00000095485" "CWF19L1" "B4DHX1; D3DR66; hsa:55280; Q5W0I3; Q69YN2; Q96HC3; Q9H865; Q9NV13" "" "" "0" "0" "1.018" "1.006" "0.959" "1.010" "0.960" "0.991" "0.961" "0.976" "0.915" "2812.3" "2864.0" "2829.9" "2696.4" "2841.5" "2699.1" "2785.9" "2702.5" "2745.6" "2573.8" "" "" "" "" "" "" "" "" "" "" "2528.6" "2317.5" "2559.7" "2632.1" "2344.9" "2699.1" "2086.0" "2387.1" "2456.7" "918.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529586358305545684" "False" "High" "IsMasterProtein" "P04181" "Ornithine aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OAT PE=1 SV=1" "0.000" "False" "87.243" "41" "15" "34" "15" "439" "48.5" "7.03" "129.93" "15" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00202" "4942" "ENSG00000065154" "OAT" "D3DRF0; hsa:4942; P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03" "Amino acid metabolism; 22q11.2 copy number variation syndrome; Creatine pathway" "Glutamate and glutamine metabolism" "4" "0" "1.000" "1.143" "1.039" "1.026" "1.096" "1.032" "0.986" "1.153" "0.790" "2357.5" "2357.5" "2693.9" "2449.0" "2419.2" "2584.9" "2433.6" "2323.6" "2717.3" "1862.6" "" "" "" "" "" "" "" "" "" "" "2119.6" "1907.6" "2436.8" "2390.5" "1996.4" "2584.9" "1822.2" "2052.4" "2431.4" "664.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "152076562272560972" "False" "High" "IsMasterProtein" "Q13409" "Cytoplasmic dynein 1 intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1I2 PE=1 SV=3" "0.000" "False" "87.223" "28" "12" "36" "12" "638" "71.4" "5.20" "154.04" "12" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf11540" "1781" "ENSG00000077380; ENSG00000292102" "DYNC1I2" "B7ZA04; D3DPD4; D3DPD5; D3DPD6; hsa:1781; Q13409; Q32LY9; Q53S84; Q5BJF8; Q7Z4X1; Q96NG7; Q96S87; Q9BXZ5; Q9NT58" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption; HDAC6 interactions in the central nervous system" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; MHC class II antigen presentation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; HCMV Early Events; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "23" "0" "0.959" "0.943" "0.967" "0.986" "0.950" "0.980" "0.966" "0.973" "0.847" "1940.6" "1861.7" "1830.3" "1877.4" "1913.0" "1842.7" "1902.1" "1874.5" "1888.9" "1643.4" "" "" "" "" "" "" "" "" "" "" "1744.8" "1506.4" "1655.5" "1832.6" "1578.7" "1842.7" "1424.2" "1655.7" "1690.2" "586.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3934264021141742446" "False" "High" "IsMasterProtein" "Q9UI12" "V-type proton ATPase subunit H OS=Homo sapiens OX=9606 GN=ATP6V1H PE=1 SV=1" "0.000" "False" "87.183" "43" "17" "32" "17" "483" "55.8" "6.48" "108.86" "17" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity;enzyme regulator activity" "Pf03224, Pf11698" "51606" "ENSG00000047249" "ATP6V1H" "B3KMR0; hsa:51606; Q6PK44; Q9H3E3; Q9UI12; Q9Y300" "Proximal tubule transport" "Nef Mediated CD4 Down-regulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport; Nef Mediated CD8 Down-regulation; Blockage of phagosome acidification" "9" "0" "1.065" "1.053" "0.981" "1.050" "0.983" "1.015" "1.036" "1.000" "0.956" "2549.6" "2714.2" "2685.8" "2502.3" "2676.3" "2505.7" "2586.8" "2640.9" "2550.4" "2438.4" "" "" "" "" "" "" "" "" "" "" "2292.4" "2196.3" "2429.4" "2442.6" "2208.6" "2505.7" "1936.9" "2332.6" "2282.1" "870.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2616426161905977358" "False" "High" "IsMasterProtein" "Q9UG63" "ATP-binding cassette sub-family F member 2 OS=Homo sapiens OX=9606 GN=ABCF2 PE=1 SV=2" "0.000" "False" "87.159" "33" "18" "32" "18" "623" "71.2" "7.37" "117.04" "18" "" "" "other molecular function" "Pf00005, Pf12848" "10061; 114483834" "ENSG00000033050" "ABCF2" "hsa:10061; hsa:114483834; O60864; Q75MJ0; Q75MJ1; Q96TE8; Q9UG63" "VEGFA-VEGFR2 signaling" "NFE2L2 regulating MDR associated enzymes" "2" "0" "1.203" "1.270" "0.996" "1.154" "1.437" "1.075" "1.136" "1.357" "1.082" "1826.0" "2196.5" "2319.2" "1819.4" "2108.0" "2623.4" "1963.3" "2073.8" "2477.5" "1976.1" "" "" "" "" "" "" "" "" "" "" "1641.7" "1777.3" "2097.8" "1776.0" "1739.5" "2623.4" "1470.0" "1831.7" "2216.8" "705.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5348588292702008792" "False" "High" "IsMasterProtein" "O94888" "UBX domain-containing protein 7 OS=Homo sapiens OX=9606 GN=UBXN7 PE=1 SV=2" "0.000" "False" "87.105" "40" "15" "29" "15" "489" "54.8" "5.16" "119.86" "15" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00789, Pf13899, Pf14555" "26043" "ENSG00000163960" "UBXN7" "D3DXB3; hsa:26043; O94888; Q6ZP77; Q86X20; Q8N327" "3q29 copy number variation syndrome" "Neddylation; KEAP1-NFE2L2 pathway" "3" "0" "0.985" "0.997" "0.980" "1.031" "1.015" "1.070" "1.018" "1.034" "0.919" "2059.9" "2029.2" "2053.7" "2018.0" "2123.6" "2089.9" "2204.4" "2097.1" "2130.4" "1892.6" "" "" "" "" "" "" "" "" "" "" "1852.0" "1642.0" "1857.6" "1969.8" "1752.4" "2089.9" "1650.6" "1852.3" "1906.3" "675.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139942290346830630" "False" "High" "IsMasterProtein" "P30084" "Enoyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=ECHS1 PE=1 SV=4" "0.000" "False" "86.954" "48" "12" "33" "12" "290" "31.4" "8.07" "136.91" "12" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1892" "ENSG00000127884" "ECHS1" "hsa:1892; O00739; P30084; Q5VWY1; Q96H54" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Ciliary landscape; Tryptophan metabolism" "Branched-chain amino acid catabolism; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "10" "0" "1.006" "1.077" "1.030" "1.050" "1.039" "1.028" "1.041" "1.027" "0.807" "3900.7" "3923.4" "4199.6" "4016.1" "4095.5" "4050.9" "4011.1" "4062.6" "4004.4" "3146.3" "" "" "" "" "" "" "" "" "" "" "3507.1" "3174.7" "3798.7" "3920.3" "3379.7" "4050.9" "3003.4" "3588.3" "3583.1" "1123.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934522081491213014" "False" "High" "IsMasterProtein" "P11908" "Ribose-phosphate pyrophosphokinase 2 OS=Homo sapiens OX=9606 GN=PRPS2 PE=1 SV=2" "0.000" "False" "86.892" "46" "14" "41" "5" "318" "34.7" "6.61" "183.42" "14" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf13793, Pf14572" "5634" "ENSG00000101911" "PRPS2" "hsa:5634; P11908; Q0VDH9; Q0VDI0; Q15245; Q2TAK7" "" "5-Phosphoribose 1-diphosphate biosynthesis" "1" "0" "1.013" "1.097" "0.965" "1.036" "1.045" "1.026" "1.035" "1.059" "0.798" "1349.6" "1367.3" "1481.1" "1302.4" "1398.5" "1410.3" "1384.8" "1396.5" "1429.4" "1076.3" "" "" "" "" "" "" "" "" "" "" "1213.4" "1106.3" "1339.7" "1271.4" "1154.1" "1410.3" "1036.9" "1233.5" "1279.0" "384.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6712994512663593747" "False" "High" "IsMasterProtein" "Q4G0N4" "NAD kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=NADK2 PE=1 SV=2" "0.000" "False" "86.830" "50" "19" "31" "19" "442" "49.4" "8.18" "123.33" "19" "other metabolic processes" "mitochondrion" "kinase activity;other molecular function" "Pf01513" "133686" "ENSG00000152620" "NADK2" "B5MC93; hsa:133686; Q4G0N4; Q6UTX5; Q96NM0" "" "Mitochondrial protein degradation; Nicotinate metabolism" "2" "0" "1.031" "1.005" "0.980" "1.024" "0.954" "1.030" "1.008" "0.985" "0.908" "1918.9" "1978.1" "1928.8" "1880.0" "1964.4" "1830.0" "1975.8" "1934.2" "1890.6" "1742.7" "" "" "" "" "" "" "" "" "" "" "1725.3" "1600.6" "1744.7" "1835.2" "1621.0" "1830.0" "1479.4" "1708.4" "1691.7" "622.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033578792166200150" "False" "High" "IsMasterProtein" "Q99729" "Heterogeneous nuclear ribonucleoprotein A/B OS=Homo sapiens OX=9606 GN=HNRNPAB PE=1 SV=2" "0.000" "False" "86.803" "33" "13" "69" "11" "332" "36.2" "8.21" "228.17" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08143" "3182" "ENSG00000197451" "HNRNPAB" "B3KNN5; D3DWP7; hsa:3182; Q04150; Q8N7U3; Q99729; Q9BQ99" "Pre-implantation embryo; mRNA processing" "" "2" "0" "0.966" "0.941" "1.046" "0.938" "1.003" "0.974" "1.040" "0.955" "0.696" "4851.6" "4688.9" "4563.3" "5075.8" "4548.9" "4866.8" "4724.8" "5046.2" "4635.5" "3377.1" "" "" "" "" "" "" "" "" "" "" "4362.0" "3794.1" "4127.7" "4954.6" "3753.8" "4866.8" "3537.8" "4457.1" "4147.8" "1205.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4892989875718200247" "False" "High" "IsMasterProtein" "Q9UL46" "Proteasome activator complex subunit 2 OS=Homo sapiens OX=9606 GN=PSME2 PE=1 SV=4" "0.000" "False" "86.648" "52" "14" "49" "14" "239" "27.4" "5.73" "135.42" "14" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02251, Pf02252" "5721" "ENSG00000100911; ENSG00000284889" "PSME2" "hsa:5721; Q15129; Q9UL46" "Proteasome degradation" "Ub-specific processing proteases; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; SCF-beta-TrCP mediated degradation of Emi1; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; KEAP1-NFE2L2 pathway; Somitogenesis; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity" "61" "0" "0.981" "1.040" "1.049" "1.055" "1.006" "1.035" "1.012" "1.048" "0.802" "3357.6" "3292.3" "3492.5" "3521.3" "3542.2" "3377.0" "3476.0" "3396.5" "3518.7" "2692.2" "" "" "" "" "" "" "" "" "" "" "3018.8" "2664.0" "3159.1" "3437.3" "2923.1" "3377.0" "2602.8" "3000.0" "3148.5" "961.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5455074280924099638" "False" "High" "IsMasterProtein" "Q15554" "Telomeric repeat-binding factor 2 OS=Homo sapiens OX=9606 GN=TERF2 PE=1 SV=3" "0.000" "False" "86.646" "38" "15" "28" "15" "542" "59.6" "9.35" "123.99" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf08558, Pf16772" "7014" "ENSG00000132604" "TERF2" "hsa:7014; Q15554" "Hematopoietic stem cell gene regulation by GABP alpha/beta complex; DNA repair pathways, full network; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Removal of the Flap Intermediate from the C-strand" "17" "0" "1.024" "0.966" "0.996" "1.061" "0.967" "1.026" "1.040" "0.985" "0.935" "2584.4" "2645.8" "2497.5" "2573.7" "2742.9" "2498.7" "2652.1" "2687.2" "2545.4" "2415.3" "" "" "" "" "" "" "" "" "" "" "2323.7" "2140.9" "2259.0" "2512.3" "2263.5" "2498.7" "1985.8" "2373.5" "2277.6" "862.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4414098033661647234" "False" "High" "IsMasterProtein" "O43488" "Aflatoxin B1 aldehyde reductase member 2 OS=Homo sapiens OX=9606 GN=AKR7A2 PE=1 SV=3" "0.000" "False" "86.602" "30" "11" "44" "11" "359" "39.6" "7.17" "153.83" "11" "other metabolic processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00248" "8574" "ENSG00000053371" "AKR7A2" "hsa:8574; O43488; O75749; Q5TG63" "Aflatoxin B1 metabolism; Metapathway biotransformation Phase I and II" "Aflatoxin activation and detoxification" "3" "0" "1.028" "1.021" "1.021" "1.021" "0.983" "1.005" "1.041" "1.007" "0.789" "2609.1" "2682.9" "2665.0" "2663.3" "2664.2" "2565.1" "2621.6" "2714.8" "2628.2" "2058.9" "" "" "" "" "" "" "" "" "" "" "2345.9" "2170.9" "2410.6" "2599.7" "2198.6" "2565.1" "1963.0" "2397.9" "2351.7" "735.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2563545888999241244" "False" "High" "IsMasterProtein" "Q9P2D3" "HEAT repeat-containing protein 5B OS=Homo sapiens OX=9606 GN=HEATR5B PE=1 SV=2" "0.000" "False" "86.520" "13" "22" "27" "22" "2071" "224.2" "7.17" "94.69" "22" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf20210" "54497" "ENSG00000008869" "HEATR5B" "B5MDU8; hsa:54497; Q7Z3B2; Q9NVL7; Q9P2D3" "" "" "0" "0" "1.057" "1.056" "0.957" "1.048" "0.978" "1.044" "1.004" "1.011" "0.990" "2698.2" "2852.5" "2849.0" "2583.0" "2827.7" "2639.6" "2817.3" "2709.6" "2729.2" "2671.4" "" "" "" "" "" "" "" "" "" "" "2426.0" "2308.1" "2577.0" "2521.3" "2333.5" "2639.6" "2109.5" "2393.3" "2442.1" "953.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3625950205882740020" "False" "High" "IsMasterProtein" "Q9NWQ8" "Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 OS=Homo sapiens OX=9606 GN=PAG1 PE=1 SV=2" "0.000" "False" "86.458" "44" "13" "33" "13" "432" "47.0" "4.65" "128.19" "13" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15347" "55824" "ENSG00000076641" "PAG1" "A8K1A3; hsa:55824; Q2M1Z9; Q5BKU4; Q9NWQ8; Q9NYK0" "" "Phosphorylation of CD3 and TCR zeta chains; GAB1 signalosome" "2" "0" "0.930" "0.891" "1.025" "0.942" "0.909" "0.983" "0.981" "0.890" "0.704" "3318.9" "3087.5" "2958.1" "3402.0" "3128.1" "3018.1" "3262.3" "3254.3" "2952.6" "2336.1" "" "" "" "" "" "" "" "" "" "" "2984.0" "2498.3" "2675.7" "3320.8" "2581.3" "3018.1" "2442.7" "2874.4" "2642.0" "833.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2958719848471143183" "False" "High" "IsMasterProtein" "P54687" "Branched-chain-amino-acid aminotransferase, cytosolic OS=Homo sapiens OX=9606 GN=BCAT1 PE=1 SV=3" "0.000" "False" "86.427" "42" "13" "42" "13" "386" "42.9" "5.30" "156.74" "13" "cell cycle OR cell proliferation;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01063" "586" "ENSG00000060982" "BCAT1" "B3KY27; B7Z2M5; B7Z5L0; F5H5E4; hsa:586; P54687; Q68DQ7; Q96MY9" "Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "4" "0" "1.008" "1.044" "1.091" "1.136" "0.996" "1.009" "0.995" "1.101" "0.818" "4118.8" "4150.2" "4299.0" "4493.1" "4677.7" "4101.6" "4155.0" "4097.9" "4533.3" "3367.8" "" "" "" "" "" "" "" "" "" "" "3703.2" "3358.2" "3888.6" "4385.9" "3860.1" "4101.6" "3111.2" "3619.5" "4056.3" "1202.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3873794915793825420" "False" "High" "IsMasterProtein" "Q9BYT8" "Neurolysin, mitochondrial OS=Homo sapiens OX=9606 GN=NLN PE=1 SV=1" "0.000" "False" "86.299" "28" "19" "32" "19" "704" "80.6" "6.64" "126.37" "19" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf01432" "57486" "ENSG00000123213" "NLN" "hsa:57486; Q9BYT8; Q9ULJ4" "" "Peptide ligand-binding receptors" "1" "0" "1.071" "1.008" "1.021" "1.082" "1.017" "1.038" "1.043" "1.057" "0.926" "1909.6" "2044.2" "1925.3" "1949.0" "2066.9" "1941.7" "1982.6" "1992.3" "2019.4" "1768.2" "" "" "" "" "" "" "" "" "" "" "1716.9" "1654.1" "1741.5" "1902.5" "1705.7" "1941.7" "1484.5" "1759.7" "1806.9" "631.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658594625945977388" "False" "High" "IsMasterProtein" "O00139" "Kinesin-like protein KIF2A OS=Homo sapiens OX=9606 GN=KIF2A PE=1 SV=3" "0.000" "False" "86.268" "29" "20" "34" "19" "706" "79.9" "6.68" "123.40" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3796" "ENSG00000068796" "KIF2A" "A5YM42; A5YM54; B4DY54; D3DW97; E9PB70; hsa:3796; O00139; Q7Z5I3; Q8N5Q7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "1" "1.053" "1.087" "0.910" "1.001" "1.087" "1.000" "0.991" "1.087" "1.017" "3248.8" "3420.5" "3532.9" "2956.5" "3250.7" "3532.3" "3247.3" "3219.1" "3530.4" "3303.7" "" "" "" "" "" "" "" "" "" "" "2920.9" "2767.8" "3195.7" "2885.9" "2682.5" "3532.3" "2431.5" "2843.4" "3159.0" "1179.3" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3827413943900730422" "False" "High" "IsMasterProtein" "Q9Y2W2" "WW domain-binding protein 11 OS=Homo sapiens OX=9606 GN=WBP11 PE=1 SV=1" "0.000" "False" "86.225" "29" "17" "39" "17" "641" "70.0" "8.38" "136.85" "17" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09429" "51729" "ENSG00000084463" "WBP11" "hsa:51729; Q96AY8; Q9Y2W2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.952" "1.035" "0.976" "1.009" "1.048" "0.972" "1.025" "1.013" "0.790" "3914.6" "3728.7" "4053.5" "3822.6" "3948.5" "4102.5" "3804.0" "4014.2" "3966.0" "3091.5" "" "" "" "" "" "" "" "" "" "" "3519.7" "3017.1" "3666.6" "3731.4" "3258.4" "4102.5" "2848.3" "3545.6" "3548.8" "1103.6" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7172207260123364247" "False" "High" "IsMasterProtein" "P11172" "Uridine 5'-monophosphate synthase OS=Homo sapiens OX=9606 GN=UMPS PE=1 SV=1" "0.000" "False" "86.193" "42" "18" "33" "18" "480" "52.2" "7.24" "115.27" "18" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00156, Pf00215" "7372" "ENSG00000114491" "UMPS" "B5LY68; B5LY72; hsa:7372; O00758; O00759; O00760; P11172; Q16862; Q9H3Q2; Q9UG49" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine biosynthesis" "3" "0" "1.006" "1.009" "0.932" "1.022" "0.973" "0.959" "0.985" "1.020" "0.818" "3054.4" "3071.5" "3081.0" "2846.4" "3122.6" "2972.9" "2928.2" "3008.3" "3114.0" "2499.2" "" "" "" "" "" "" "" "" "" "" "2746.2" "2485.3" "2786.8" "2778.5" "2576.9" "2972.9" "2192.5" "2657.1" "2786.4" "892.1" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386801928701098306" "False" "High" "IsMasterProtein" "Q6ULP2" "Aftiphilin OS=Homo sapiens OX=9606 GN=AFTPH PE=1 SV=3" "0.000" "False" "85.918" "28" "20" "27" "20" "936" "102.1" "4.54" "104.57" "20" "transport" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15045" "54812" "ENSG00000119844" "AFTPH" "D6W5E9; hsa:54812; Q6ULP2; Q6ZM66; Q86VW3; Q8TCF3; Q9H7E3; Q9HAB9; Q9NXS4" "" "" "0" "0" "0.996" "0.981" "0.988" "1.009" "0.989" "1.009" "0.982" "0.972" "0.906" "2626.0" "2615.1" "2576.0" "2593.2" "2649.1" "2596.0" "2649.0" "2577.5" "2551.9" "2379.6" "" "" "" "" "" "" "" "" "" "" "2361.0" "2116.0" "2330.1" "2531.3" "2186.1" "2596.0" "1983.5" "2276.6" "2283.4" "849.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1425618486899947959" "False" "High" "IsMasterProtein" "Q7Z4H3" "5'-deoxynucleotidase HDDC2 OS=Homo sapiens OX=9606 GN=HDDC2 PE=1 SV=1" "0.000" "False" "85.879" "78" "12" "34" "12" "204" "23.4" "5.49" "127.13" "12" "" "" "other molecular function" "Pf13023" "51020" "ENSG00000111906" "HDDC2" "hsa:51020; Q5TDQ4; Q6NZ49; Q7Z4H3; Q9BTT2; Q9BV31; Q9Y3D1" "" "" "0" "0" "0.975" "0.934" "0.996" "1.005" "0.990" "1.036" "1.030" "1.003" "0.798" "1876.5" "1829.8" "1752.4" "1869.7" "1885.1" "1856.9" "1945.0" "1931.9" "1883.0" "1498.1" "" "" "" "" "" "" "" "" "" "" "1687.2" "1480.6" "1585.1" "1825.1" "1555.6" "1856.9" "1456.4" "1706.4" "1684.9" "534.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "774032980472200148" "False" "High" "IsMasterProtein" "P80404" "4-aminobutyrate aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=ABAT PE=1 SV=3" "0.000" "False" "85.872" "45" "19" "32" "19" "500" "56.4" "7.96" "125.74" "19" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00202" "18" "ENSG00000183044" "ABAT" "A8K386; hsa:18; P80404; Q16260; Q8N5W2; Q96BG2; Q99800" "Alanine and aspartate metabolism; Valproic acid pathway; Fragile X syndrome" "Degradation of GABA" "4" "0" "0.997" "1.013" "0.951" "1.041" "0.968" "0.990" "1.000" "1.000" "0.787" "2880.5" "2872.3" "2917.7" "2740.0" "2998.3" "2787.9" "2851.4" "2879.8" "2880.2" "2266.0" "" "" "" "" "" "" "" "" "" "" "2589.8" "2324.1" "2639.1" "2674.6" "2474.2" "2787.9" "2135.0" "2543.6" "2577.2" "808.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8649705542655534815" "False" "High" "IsMasterProtein" "Q8N573" "Oxidation resistance protein 1 OS=Homo sapiens OX=9606 GN=OXR1 PE=1 SV=2" "0.000" "False" "85.825" "27" "20" "25" "20" "874" "97.9" "5.47" "107.00" "20" "stress response;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01476, Pf07534" "55074" "ENSG00000164830" "OXR1" "A6NK11; A8KA34; B3KXL1; B7Z402; B7Z8N5; D3HIS6; hsa:55074; Q3LIB5; Q6ZVK9; Q8N573; Q8N8V0; Q9H266; Q9NWC7" "" "" "0" "0" "0.960" "0.922" "0.952" "1.039" "0.941" "1.023" "1.031" "0.961" "0.823" "2105.2" "2020.7" "1941.5" "2003.3" "2187.1" "1980.8" "2153.7" "2171.3" "2022.7" "1733.1" "" "" "" "" "" "" "" "" "" "" "1892.8" "1635.1" "1756.2" "1955.5" "1804.9" "1980.8" "1612.7" "1917.9" "1809.9" "618.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634155616669097337" "False" "High" "IsMasterProtein" "P42768" "Actin nucleation-promoting factor WAS OS=Homo sapiens OX=9606 GN=WAS PE=1 SV=4" "0.000" "False" "85.630" "43" "16" "38" "16" "502" "52.9" "6.64" "150.69" "16" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00568, Pf00786, Pf02205" "7454" "ENSG00000015285" "WAS" "hsa:7454; P42768; Q9BU11; Q9UNJ9" "Pathogenic Escherichia coli infection; Complement system; Chemokine signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Generation of second messenger molecules; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle" "13" "0" "0.971" "0.946" "1.008" "0.982" "0.952" "1.011" "0.975" "0.898" "1.106" "2373.3" "2304.0" "2246.2" "2393.0" "2331.5" "2260.5" "2398.6" "2313.3" "2131.7" "2625.9" "" "" "" "" "" "" "" "" "" "" "2133.8" "1864.3" "2031.8" "2335.9" "1924.0" "2260.5" "1796.0" "2043.3" "1907.4" "937.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8496601930648358283" "False" "High" "IsMasterProtein" "Q5T6F2" "Ubiquitin-associated protein 2 OS=Homo sapiens OX=9606 GN=UBAP2 PE=1 SV=1" "0.000" "False" "85.566" "19" "15" "25" "15" "1119" "117.0" "7.34" "100.43" "15" "other biological processes" "nucleus;other cell component" "" "Pf12478" "55833" "ENSG00000137073" "UBAP2" "hsa:55833; Q2M2R4; Q5JV03; Q5T6F2; Q6PK34; Q8NC94; Q9P237" "" "" "0" "0" "0.963" "0.999" "1.001" "0.989" "1.031" "1.017" "1.021" "1.008" "0.808" "2478.9" "2387.9" "2476.8" "2482.6" "2450.4" "2554.9" "2521.6" "2530.4" "2497.9" "2002.5" "" "" "" "" "" "" "" "" "" "" "2228.8" "1932.2" "2240.4" "2423.4" "2022.1" "2554.9" "1888.1" "2235.0" "2235.1" "714.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415542887713691593" "False" "High" "IsMasterProtein" "Q01469" "Fatty acid-binding protein 5 OS=Homo sapiens OX=9606 GN=FABP5 PE=1 SV=3" "0.000" "False" "85.546" "79" "14" "83" "14" "135" "15.2" "7.01" "312.26" "14" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00061" "2171" "ENSG00000164687" "FABP5" "B2R4K0; hsa:2171; Q01469" "PPAR signaling pathway; Fatty acid transporters" "Neutrophil degranulation; Triglyceride catabolism; Signaling by Retinoic Acid" "5" "0" "0.948" "0.940" "1.069" "0.933" "1.052" "1.000" "1.054" "0.942" "0.803" "7779.6" "7376.5" "7309.8" "8318.6" "7257.0" "8182.9" "7780.9" "8197.1" "7330.6" "6247.7" "" "" "" "" "" "" "" "" "" "" "6994.6" "5968.8" "6611.9" "8120.1" "5988.6" "8182.9" "5826.1" "7240.2" "6559.4" "2230.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387303708123169852" "False" "High" "IsMasterProtein" "P07602" "Prosaposin OS=Homo sapiens OX=9606 GN=PSAP PE=1 SV=2" "0.000" "False" "85.495" "27" "14" "36" "14" "524" "58.1" "5.17" "119.71" "14" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02199, Pf03489, Pf05184" "5660" "ENSG00000197746" "PSAP" "hsa:5660; P07292; P07602; P15793; P78538; P78541; P78546; P78547; P78558; Q53Y86; Q6IBQ6; Q92739; Q92740; Q92741; Q92742" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; G alpha (i) signalling events; Platelet degranulation ; Peptide ligand-binding receptors; Glycosphingolipid catabolism" "6" "0" "0.931" "0.972" "0.940" "1.010" "1.015" "0.976" "1.040" "1.053" "0.822" "4118.4" "3835.8" "4001.3" "3871.4" "4157.8" "4182.1" "4017.9" "4283.1" "4338.6" "3384.1" "" "" "" "" "" "" "" "" "" "" "3702.9" "3103.8" "3619.3" "3779.0" "3431.1" "4182.1" "3008.5" "3783.1" "3882.2" "1208.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895528791649615838" "False" "High" "IsMasterProtein" "Q86UE4" "Protein LYRIC OS=Homo sapiens OX=9606 GN=MTDH PE=1 SV=2" "0.000" "False" "85.485" "30" "15" "27" "15" "582" "63.8" "9.32" "115.39" "15" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15686" "92140" "ENSG00000147649" "MTDH" "hsa:92140; Q05DH2; Q52QU9; Q6PK07; Q86UE4; Q8TCX3" "Gastric cancer network 2; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; CCL18 signaling pathway" "" "3" "0" "0.965" "0.933" "1.022" "1.033" "0.997" "1.049" "0.989" "0.911" "0.727" "2695.1" "2601.6" "2514.1" "2753.2" "2783.0" "2686.4" "2828.2" "2665.3" "2454.5" "1959.0" "" "" "" "" "" "" "" "" "" "" "2423.1" "2105.1" "2274.1" "2687.5" "2296.6" "2686.4" "2117.7" "2354.1" "2196.3" "699.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8338185896590092974" "False" "High" "IsMasterProtein" "Q9H0B6" "Kinesin light chain 2 OS=Homo sapiens OX=9606 GN=KLC2 PE=1 SV=1" "0.000" "False" "85.364" "39" "21" "29" "14" "622" "68.9" "7.15" "104.03" "21" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf13424" "64837" "ENSG00000174996" "KLC2" "A8MXL7; B2RDY4; hsa:64837; Q9H0B6; Q9H9C8; Q9HA20" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "6" "1" "0.971" "0.995" "0.984" "1.013" "0.985" "1.010" "0.991" "0.998" "1.038" "2048.3" "1989.9" "2038.9" "2015.0" "2074.6" "2016.6" "2069.6" "2029.5" "2045.1" "2126.9" "" "" "" "" "" "" "" "" "" "" "1841.7" "1610.2" "1844.3" "1966.9" "1712.0" "2016.6" "1549.6" "1792.6" "1830.0" "759.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8048199414682788645" "False" "High" "IsMasterProtein" "Q06323" "Proteasome activator complex subunit 1 OS=Homo sapiens OX=9606 GN=PSME1 PE=1 SV=1" "0.000" "False" "85.360" "59" "15" "43" "15" "249" "28.7" "6.02" "153.69" "15" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf02251, Pf02252" "5720" "ENSG00000092010; ENSG00000284916" "PSME1" "A6NJG9; H0YNE3; hsa:5720; Q06323; Q6IBM2; Q9UEF4" "Proteasome degradation" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "0.956" "0.976" "0.990" "1.026" "0.953" "1.056" "1.069" "1.020" "0.766" "4987.4" "4767.2" "4866.0" "4939.7" "5118.5" "4753.7" "5265.4" "5330.4" "5085.6" "3818.8" "" "" "" "" "" "" "" "" "" "" "4484.1" "3857.4" "4401.4" "4821.8" "4223.9" "4753.7" "3942.6" "4708.2" "4550.5" "1363.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7237194878275625611" "False" "High" "IsMasterProtein" "Q9Y224" "RNA transcription, translation and transport factor protein OS=Homo sapiens OX=9606 GN=RTRAF PE=1 SV=1" "0.000" "False" "85.345" "64" "15" "35" "15" "244" "28.1" "6.65" "124.37" "15" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10036" "51637" "ENSG00000087302" "RTRAF" "hsa:51637; Q9Y224" "" "tRNA processing in the nucleus" "1" "0" "0.982" "1.057" "1.016" "1.027" "1.043" "1.036" "1.036" "1.044" "0.819" "3174.3" "3116.9" "3355.0" "3223.7" "3259.3" "3312.1" "3287.6" "3287.0" "3312.5" "2600.3" "" "" "" "" "" "" "" "" "" "" "2854.0" "2522.1" "3034.7" "3146.8" "2689.6" "3312.1" "2461.6" "2903.2" "2964.0" "928.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6299048692266605018" "False" "High" "IsMasterProtein" "Q14161" "ARF GTPase-activating protein GIT2 OS=Homo sapiens OX=9606 GN=GIT2 PE=1 SV=2" "0.000" "False" "85.323" "29" "20" "29" "17" "759" "84.5" "7.23" "111.00" "20" "transport;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf01412, Pf08518, Pf12205, Pf16559" "9815" "ENSG00000139436" "GIT2" "hsa:9815; Q14161; Q86U59; Q96CI2; Q9BV91; Q9Y5V2" "Integrin-mediated cell adhesion" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle" "9" "1" "1.035" "0.949" "0.999" "1.029" "0.964" "1.051" "1.026" "1.016" "1.077" "2838.2" "2937.4" "2693.4" "2836.4" "2920.6" "2737.1" "2982.7" "2910.8" "2882.2" "3055.7" "" "" "" "" "" "" "" "" "" "" "2551.8" "2376.8" "2436.3" "2768.7" "2410.1" "2737.1" "2233.4" "2571.0" "2578.9" "1090.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558081350695480590" "False" "High" "IsMasterProtein" "O43172" "U4/U6 small nuclear ribonucleoprotein Prp4 OS=Homo sapiens OX=9606 GN=PRPF4 PE=1 SV=2" "0.000" "False" "85.226" "47" "19" "29" "19" "522" "58.4" "7.42" "111.41" "19" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf08799" "9128" "ENSG00000136875" "PRPF4" "hsa:9128; O43172; O43445; O43864; Q5T1M8; Q96DG2; Q96IK4" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.980" "0.954" "0.940" "0.994" "1.032" "0.973" "0.984" "0.939" "1.002" "1771.7" "1737.1" "1691.0" "1666.3" "1761.2" "1829.3" "1723.6" "1742.9" "1663.0" "1774.8" "" "" "" "" "" "" "" "" "" "" "1593.0" "1405.6" "1529.6" "1626.5" "1453.3" "1829.3" "1290.6" "1539.4" "1488.0" "633.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7367615421387894087" "False" "High" "IsMasterProtein" "Q9Y5X3" "Sorting nexin-5 OS=Homo sapiens OX=9606 GN=SNX5 PE=1 SV=1" "0.000" "False" "85.202" "55" "19" "29" "18" "404" "46.8" "6.76" "113.85" "19" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "27131" "ENSG00000089006" "SNX5" "B7ZKN3; D3DW26; hsa:27131; Q52LC4; Q7KZN0; Q9BWP0; Q9Y5X3" "" "Golgi Associated Vesicle Biogenesis" "1" "2" "0.903" "0.923" "1.012" "0.883" "0.831" "1.011" "0.844" "0.820" "1.523" "3470.5" "3134.8" "3202.5" "3512.8" "3064.5" "2885.4" "3509.9" "2929.0" "2845.4" "5287.0" "" "" "" "" "" "" "" "" "" "" "3120.4" "2536.6" "2896.8" "3428.9" "2528.9" "2885.4" "2628.1" "2587.1" "2546.0" "1887.3" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047119725647514999" "False" "High" "IsMasterProtein" "P23588" "Eukaryotic translation initiation factor 4B OS=Homo sapiens OX=9606 GN=EIF4B PE=1 SV=2" "0.000" "False" "85.169" "31" "19" "65" "19" "611" "69.1" "5.73" "217.32" "19" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "nucleic acid binding activity" "Pf00076" "1975" "ENSG00000063046" "EIF4B" "B4DS13; hsa:1975; P23588; Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5" "Translation factors; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Interferon type I signaling pathways" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "16" "0" "0.962" "0.962" "0.929" "0.943" "0.957" "0.950" "1.021" "0.900" "0.777" "5486.0" "5277.8" "5275.1" "5094.3" "5175.4" "5251.4" "5213.8" "5600.4" "4938.9" "4261.5" "" "" "" "" "" "" "" "" "" "" "4932.5" "4270.6" "4771.5" "4972.8" "4270.8" "5251.4" "3904.0" "4946.6" "4419.3" "1521.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681400762000750361" "False" "High" "IsMasterProtein" "O60749" "Sorting nexin-2 OS=Homo sapiens OX=9606 GN=SNX2 PE=1 SV=2" "0.000" "False" "85.161" "38" "17" "32" "15" "519" "58.4" "5.12" "121.99" "17" "cell organization and biogenesis;transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6643" "ENSG00000205302" "SNX2" "B3KN44; B4DEK4; B7Z408; hsa:6643; O43650; O60749; P82862; Q53XK8; Q597H6; Q9BTS8" "" "Golgi Associated Vesicle Biogenesis" "1" "2" "0.898" "0.885" "1.003" "0.903" "0.835" "1.049" "0.836" "0.797" "1.567" "3572.6" "3209.6" "3160.2" "3582.0" "3227.9" "2982.9" "3749.5" "2985.1" "2848.8" "5598.3" "" "" "" "" "" "" "" "" "" "" "3212.1" "2597.1" "2858.5" "3496.5" "2663.7" "2982.9" "2807.5" "2636.6" "2549.1" "1998.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1264593624988505849" "False" "High" "IsMasterProtein" "Q14694" "Ubiquitin carboxyl-terminal hydrolase 10 OS=Homo sapiens OX=9606 GN=USP10 PE=1 SV=2" "0.000" "False" "85.141" "34" "19" "31" "19" "798" "87.1" "5.31" "131.88" "19" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf07145" "9100" "ENSG00000103194" "USP10" "B2RDJ8; B4DS84; hsa:9100; Q14694; Q9BWG7; Q9NSL7" "VEGFA-VEGFR2 signaling" "Ub-specific processing proteases; Termination of translesion DNA synthesis" "3" "0" "1.005" "1.036" "1.005" "1.043" "1.006" "1.006" "1.024" "1.031" "0.940" "1983.5" "1992.7" "2054.1" "1993.9" "2069.2" "1994.5" "1994.7" "2030.3" "2044.9" "1863.9" "" "" "" "" "" "" "" "" "" "" "1783.4" "1612.4" "1858.0" "1946.4" "1707.5" "1994.5" "1493.6" "1793.3" "1829.8" "665.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-564768690041684779" "False" "High" "IsMasterProtein" "Q9H0L4" "Cleavage stimulation factor subunit 2 tau variant OS=Homo sapiens OX=9606 GN=CSTF2T PE=1 SV=1" "0.000" "False" "84.977" "31" "16" "30" "10" "616" "64.4" "7.25" "112.65" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "23283" "ENSG00000177613" "CSTF2T" "B2RAR9; hsa:23283; O75174; Q53HK6; Q7LGE8; Q8N6T1; Q9H0L4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "6" "1.028" "1.010" "0.985" "0.973" "0.995" "1.010" "0.987" "0.998" "0.876" "1971.5" "2027.6" "1990.8" "1942.1" "1917.5" "1962.5" "1991.8" "1944.9" "1967.4" "1727.6" "" "" "" "" "" "" "" "" "" "" "1772.6" "1640.7" "1800.7" "1895.7" "1582.4" "1962.5" "1491.4" "1717.9" "1760.4" "616.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7380698507310522757" "False" "High" "IsMasterProtein" "P41227" "N-alpha-acetyltransferase 10 OS=Homo sapiens OX=9606 GN=NAA10 PE=1 SV=1" "0.000" "False" "84.655" "62" "14" "41" "14" "235" "26.4" "5.64" "145.22" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "8260" "ENSG00000102030" "NAA10" "A6NM98; hsa:8260; P41227" "" "" "0" "0" "0.938" "0.941" "0.990" "0.945" "0.932" "0.943" "0.974" "0.935" "0.804" "4559.6" "4277.0" "4290.3" "4514.9" "4307.8" "4247.9" "4300.5" "4439.1" "4264.7" "3664.3" "" "" "" "" "" "" "" "" "" "" "4099.5" "3460.8" "3880.7" "4407.2" "3554.9" "4247.9" "3220.1" "3920.9" "3816.0" "1308.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762043181650020657" "False" "High" "IsMasterProtein" "P46109" "Crk-like protein OS=Homo sapiens OX=9606 GN=CRKL PE=1 SV=1" "0.000" "False" "84.554" "63" "14" "38" "14" "303" "33.8" "6.74" "153.99" "14" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018, Pf07653" "1399" "ENSG00000099942" "CRKL" "A8KA44; D3DX35; hsa:1399; P46109" "Androgen receptor network in prostate cancer; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; 22q11.2 copy number variation syndrome; IL-2 signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Downstream signal transduction; Regulation of signaling by CBL; Erythropoietin activates RAS; Frs2-mediated activation; MET activates RAP1 and RAC1; MET receptor recycling" "22" "0" "0.990" "1.021" "1.026" "0.966" "0.963" "0.969" "1.003" "1.011" "0.993" "1947.6" "1927.2" "1988.4" "1998.6" "1881.5" "1875.4" "1887.9" "1952.8" "1968.0" "1934.5" "" "" "" "" "" "" "" "" "" "" "1751.0" "1559.4" "1798.6" "1951.0" "1552.6" "1875.4" "1413.6" "1724.8" "1761.0" "690.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407233124236787373" "False" "High" "IsMasterProtein" "Q96DB5" "Regulator of microtubule dynamics protein 1 OS=Homo sapiens OX=9606 GN=RMDN1 PE=1 SV=1" "0.000" "False" "84.434" "49" "15" "31" "15" "314" "35.8" "8.50" "118.44" "15" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity" "Pf21033" "51115" "ENSG00000176623" "RMDN1" "A9UMZ8; B4DNF5; B4DZW6; B5MC61; C9JSC6; E7EVI2; hsa:51115; Q96DB5; Q9Y398" "" "" "0" "0" "0.970" "0.974" "1.049" "0.997" "0.949" "0.942" "1.042" "0.993" "0.826" "2424.7" "2352.6" "2362.7" "2543.1" "2417.4" "2300.6" "2284.5" "2527.0" "2407.5" "2003.2" "" "" "" "" "" "" "" "" "" "" "2180.1" "1903.6" "2137.2" "2482.4" "1994.9" "2300.6" "1710.6" "2232.0" "2154.2" "715.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4632135778776149030" "False" "High" "IsMasterProtein" "P18085" "ADP-ribosylation factor 4 OS=Homo sapiens OX=9606 GN=ARF4 PE=1 SV=3" "0.000" "False" "84.163" "68" "11" "42" "6" "180" "20.5" "7.14" "163.70" "11" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00025" "378" "ENSG00000168374" "ARF4" "B2R7J7; hsa:378; P18085; P21371" "VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; VxPx cargo-targeting to cilium" "4" "0" "1.034" "1.094" "0.954" "1.140" "0.996" "1.062" "0.984" "1.102" "0.964" "1474.7" "1524.6" "1612.6" "1406.4" "1681.8" "1469.2" "1566.4" "1451.3" "1625.6" "1421.1" "" "" "" "" "" "" "" "" "" "" "1325.9" "1233.6" "1458.7" "1372.8" "1387.9" "1469.2" "1172.9" "1281.9" "1454.6" "507.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7322766248926009386" "False" "High" "IsMasterProtein" "Q13564" "NEDD8-activating enzyme E1 regulatory subunit OS=Homo sapiens OX=9606 GN=NAE1 PE=1 SV=1" "0.000" "False" "84.073" "40" "14" "23" "14" "534" "60.2" "5.40" "111.27" "14" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00899" "8883" "ENSG00000159593" "NAE1" "A6NCK0; A6NFN4; A8MU28; B2R700; B3KUP9; hsa:8883; Q13564" "Alzheimer's disease and miRNA effects; Hijack of ubiquitination by SARS-CoV-2; Alzheimer's disease" "Neddylation" "4" "0" "0.988" "0.933" "1.009" "0.966" "0.882" "1.042" "0.948" "0.939" "1.025" "2366.8" "2338.2" "2208.2" "2387.6" "2286.9" "2086.9" "2467.3" "2243.2" "2222.6" "2427.0" "" "" "" "" "" "" "" "" "" "" "2127.9" "1892.0" "1997.4" "2330.7" "1887.2" "2086.9" "1847.4" "1981.3" "1988.7" "866.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-154777414140805672" "False" "High" "IsMasterProtein" "P20810" "Calpastatin OS=Homo sapiens OX=9606 GN=CAST PE=1 SV=4" "0.000" "False" "84.060" "24" "14" "35" "14" "708" "76.5" "5.07" "133.00" "14" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00748" "831" "ENSG00000153113" "CAST" "B7Z468; G5E946; G5E9D3; hsa:831; O95360; P20810; Q05DE8; Q7Z4K0; Q96D08; Q9H1Z5" "" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "2" "0" "1.004" "0.930" "0.934" "0.990" "0.947" "0.986" "0.980" "0.939" "0.741" "2695.4" "2706.8" "2507.5" "2518.7" "2668.4" "2552.9" "2658.1" "2640.1" "2531.0" "1996.0" "" "" "" "" "" "" "" "" "" "" "2423.4" "2190.3" "2268.1" "2458.6" "2202.0" "2552.9" "1990.3" "2332.0" "2264.7" "712.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5620405547330282270" "False" "High" "IsMasterProtein" "Q7Z4V5" "Hepatoma-derived growth factor-related protein 2 OS=Homo sapiens OX=9606 GN=HDGFL2 PE=1 SV=1" "0.000" "False" "84.033" "34" "23" "43" "22" "671" "74.3" "7.49" "132.14" "23" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf11467" "84717" "ENSG00000167674" "HDGFL2" "I3L080; K7EQZ6; Q7Z4V5; Q96GI5; Q9BW08" "" "" "0" "0" "0.992" "0.898" "0.960" "1.018" "1.030" "0.980" "1.059" "0.976" "0.764" "2374.1" "2355.1" "2132.0" "2280.2" "2418.0" "2444.6" "2325.9" "2514.7" "2318.3" "1814.1" "" "" "" "" "" "" "" "" "" "" "2134.6" "1905.7" "1928.5" "2225.8" "1995.4" "2444.6" "1741.6" "2221.2" "2074.4" "647.6" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2297110738803864325" "False" "High" "IsMasterProtein" "P30044" "Peroxiredoxin-5, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX5 PE=1 SV=4" "0.000" "False" "83.989" "49" "11" "41" "11" "214" "22.1" "8.70" "144.90" "11" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf08534" "25824" "ENSG00000126432" "PRDX5" "A6NC19; A6NG06; B7ZLJ4; B7ZVW3; hsa:25824; P30044; Q14CK0; Q6IAF2; Q9UBU5; Q9UJU4; Q9UKX4" "Selenium micronutrient network" "" "1" "0" "1.001" "0.994" "1.019" "1.049" "0.961" "0.986" "1.000" "1.017" "0.770" "3825.8" "3829.2" "3801.9" "3898.4" "4014.8" "3676.3" "3772.7" "3825.4" "3891.2" "2947.4" "" "" "" "" "" "" "" "" "" "" "3439.8" "3098.5" "3438.9" "3805.4" "3313.1" "3676.3" "2824.9" "3378.8" "3481.8" "1052.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678846149867540289" "False" "High" "IsMasterProtein" "Q9H4A4" "Aminopeptidase B OS=Homo sapiens OX=9606 GN=RNPEP PE=1 SV=2" "0.000" "False" "83.984" "31" "19" "29" "19" "650" "72.5" "5.74" "103.78" "19" "protein metabolism" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf01433, Pf09127, Pf17900" "6051" "ENSG00000176393" "RNPEP" "hsa:6051; Q9BVM9; Q9H1D4; Q9H4A4; Q9NPT7" "" "" "0" "0" "0.960" "1.028" "0.981" "0.970" "0.941" "0.953" "0.960" "0.991" "0.996" "2241.1" "2152.2" "2304.0" "2199.4" "2173.1" "2109.9" "2136.4" "2150.4" "2221.6" "2231.5" "" "" "" "" "" "" "" "" "" "" "2015.0" "1741.5" "2084.1" "2147.0" "1793.3" "2109.9" "1599.7" "1899.4" "1987.9" "796.6" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338451157516248926" "False" "High" "IsMasterProtein" "Q96IZ0" "PRKC apoptosis WT1 regulator protein OS=Homo sapiens OX=9606 GN=PAWR PE=1 SV=1" "0.000" "False" "83.981" "38" "12" "27" "12" "340" "36.5" "5.41" "120.79" "12" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "5074" "ENSG00000177425" "PAWR" "hsa:5074; O75796; Q6FHY9; Q8N700; Q96IZ0" "" "" "0" "0" "0.896" "0.912" "0.956" "0.972" "0.953" "0.940" "0.993" "0.944" "0.754" "1880.2" "1685.2" "1714.9" "1797.3" "1826.6" "1791.3" "1767.5" "1867.1" "1775.1" "1416.8" "" "" "" "" "" "" "" "" "" "" "1690.5" "1363.6" "1551.2" "1754.4" "1507.4" "1791.3" "1323.5" "1649.1" "1588.4" "505.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5381305641147496779" "False" "High" "IsMasterProtein" "Q9HAV7" "GrpE protein homolog 1, mitochondrial OS=Homo sapiens OX=9606 GN=GRPEL1 PE=1 SV=2" "0.000" "False" "83.856" "60" "14" "45" "14" "217" "24.3" "8.12" "168.92" "14" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf01025" "80273" "ENSG00000109519" "GRPEL1" "B2R783; hsa:80273; Q549M6; Q9HAV7" "" "Mitochondrial protein import" "1" "0" "0.910" "0.942" "0.943" "0.971" "0.963" "0.957" "0.999" "0.964" "0.805" "5131.5" "4671.7" "4831.7" "4838.7" "4983.9" "4939.5" "4912.8" "5128.4" "4946.1" "4130.2" "" "" "" "" "" "" "" "" "" "" "4613.7" "3780.2" "4370.4" "4723.3" "4112.8" "4939.5" "3678.6" "4529.8" "4425.7" "1474.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3740771680866674362" "False" "High" "IsMasterProtein" "P62993" "Growth factor receptor-bound protein 2 OS=Homo sapiens OX=9606 GN=GRB2 PE=1 SV=1" "0.000" "False" "83.795" "71" "15" "44" "15" "217" "25.2" "6.32" "145.96" "15" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "2885" "ENSG00000177885" "GRB2" "hsa:2885; P29354; P62993; Q14450; Q63057; Q63059" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; IL-9 signaling pathway; Pilocytic astrocytoma; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; p38 MAPK signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 distal deletion syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Pleural mesothelioma; Congenital generalized lipodystrophy; GDNF signaling; 2q13 copy number variation syndrome; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ALK fusions and activated point mutants; Signaling by CSF3 (G-CSF); Signaling by FLT3 ITD and TKD mutants; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling" "73" "0" "1.001" "0.963" "1.011" "0.990" "0.960" "0.992" "1.027" "0.974" "0.811" "4154.2" "4157.5" "3999.3" "4201.4" "4112.9" "3989.2" "4119.3" "4266.4" "4045.5" "3370.6" "" "" "" "" "" "" "" "" "" "" "3735.0" "3364.1" "3617.5" "4101.1" "3394.0" "3989.2" "3084.4" "3768.4" "3619.9" "1203.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6626039175338175676" "False" "High" "IsMasterProtein" "Q9NXH9" "tRNA (guanine(26)-N(2))-dimethyltransferase OS=Homo sapiens OX=9606 GN=TRMT1 PE=1 SV=1" "0.000" "False" "83.784" "41" "22" "29" "22" "659" "72.2" "7.64" "115.39" "22" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf02005" "55621" "ENSG00000104907" "TRMT1" "hsa:55621; O76103; Q548Y5; Q8WVA6; Q9NXH9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.045" "1.024" "1.014" "1.063" "1.019" "1.067" "1.037" "1.022" "0.862" "1863.1" "1947.1" "1908.4" "1889.3" "1980.1" "1898.1" "1987.2" "1932.7" "1903.6" "1605.3" "" "" "" "" "" "" "" "" "" "" "1675.1" "1575.5" "1726.2" "1844.2" "1634.1" "1898.1" "1488.0" "1707.1" "1703.4" "573.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1852571755298916304" "False" "High" "IsMasterProtein" "Q9UKX7" "Nuclear pore complex protein Nup50 OS=Homo sapiens OX=9606 GN=NUP50 PE=1 SV=2" "0.000" "False" "83.700" "42" "18" "29" "18" "468" "50.1" "7.06" "113.00" "18" "transport" "other membranes;nucleus" "" "Pf00638, Pf08911" "10762" "ENSG00000093000" "NUP50" "B1AHA4; B2RB15; hsa:10762; O75644; Q8N6V5; Q9NPM9; Q9NPR6; Q9P1K5; Q9UKX7" "" "Rev-mediated nuclear export of HIV RNA; SUMOylation of DNA replication proteins; Regulation of HSF1-mediated heat shock response; snRNP Assembly; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.025" "1.039" "0.988" "1.037" "1.020" "1.021" "1.069" "1.036" "0.829" "2804.6" "2873.8" "2913.9" "2772.0" "2909.4" "2861.5" "2864.5" "2998.9" "2904.9" "2325.6" "" "" "" "" "" "" "" "" "" "" "2521.6" "2325.4" "2635.7" "2705.9" "2400.9" "2861.5" "2144.8" "2648.8" "2599.3" "830.2" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3644173202538667698" "False" "High" "IsMasterProtein" "Q9Y4B6" "DDB1- and CUL4-associated factor 1 OS=Homo sapiens OX=9606 GN=DCAF1 PE=1 SV=3" "0.000" "False" "83.552" "19" "25" "28" "25" "1507" "168.9" "5.06" "104.37" "25" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "" "9730" "ENSG00000145041" "DCAF1" "hsa:9730; Q2YD74; Q8TBD9; Q9HCA1; Q9UG37; Q9Y4B6" "Hippo-Merlin signaling dysregulation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.967" "0.941" "0.890" "0.971" "0.910" "0.960" "0.893" "0.972" "1.039" "2430.6" "2349.9" "2287.0" "2163.6" "2359.5" "2211.3" "2333.5" "2169.5" "2362.1" "2526.2" "" "" "" "" "" "" "" "" "" "" "2185.3" "1901.5" "2068.6" "2111.9" "1947.1" "2211.3" "1747.3" "1916.3" "2113.6" "901.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980500697727064305" "False" "High" "IsMasterProtein" "O43815" "Striatin OS=Homo sapiens OX=9606 GN=STRN PE=1 SV=4" "0.000" "False" "83.446" "35" "20" "26" "20" "780" "86.1" "5.27" "105.07" "20" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400, Pf08232" "6801" "ENSG00000115808" "STRN" "hsa:6801; O43815; Q3KP65; Q53TQ8; Q9NP38" "MET in type 1 papillary renal cell carcinoma" "Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "8" "0" "1.011" "0.998" "1.013" "1.028" "1.010" "1.057" "1.024" "1.071" "0.872" "1858.7" "1878.3" "1854.2" "1883.3" "1909.9" "1877.2" "1964.1" "1904.2" "1990.7" "1620.7" "" "" "" "" "" "" "" "" "" "" "1671.1" "1519.9" "1677.2" "1838.3" "1576.1" "1877.2" "1470.7" "1681.9" "1781.3" "578.5" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5413684009215812555" "False" "High" "IsMasterProtein" "O15143" "Actin-related protein 2/3 complex subunit 1B OS=Homo sapiens OX=9606 GN=ARPC1B PE=1 SV=3" "0.000" "False" "83.444" "57" "17" "40" "16" "372" "40.9" "8.35" "178.83" "17" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400" "10095" "ENSG00000130429" "ARPC1B" "hsa:10095; O15143; Q9BU00" "Pathogenic Escherichia coli infection; Microglia pathogen phagocytosis pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "1" "1.005" "0.976" "1.023" "0.969" "0.952" "0.991" "0.958" "1.011" "0.778" "5198.6" "5227.2" "5074.7" "5316.9" "5038.9" "4946.6" "5152.2" "4978.2" "5254.1" "4043.6" "" "" "" "" "" "" "" "" "" "" "4674.0" "4229.6" "4590.2" "5190.1" "4158.2" "4946.6" "3857.9" "4397.0" "4701.3" "1443.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1376480877538073283" "False" "High" "IsMasterProtein" "Q14232" "Translation initiation factor eIF2B subunit alpha OS=Homo sapiens OX=9606 GN=EIF2B1 PE=1 SV=1" "0.000" "False" "83.435" "50" "13" "41" "13" "305" "33.7" "7.33" "149.97" "13" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "1967" "ENSG00000111361" "EIF2B1" "A6NLY9; B4DGX0; hsa:1967; Q14232; Q3SXP4" "Translation factors" "Recycling of eIF2:GDP" "2" "0" "1.030" "1.047" "1.007" "1.009" "1.004" "1.044" "0.990" "1.042" "0.875" "5160.1" "5314.5" "5402.0" "5196.7" "5207.7" "5181.1" "5385.7" "5106.7" "5378.0" "4513.7" "" "" "" "" "" "" "" "" "" "" "4639.4" "4300.3" "4886.3" "5072.7" "4297.5" "5181.1" "4032.7" "4510.6" "4812.2" "1611.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6570966043889327404" "False" "High" "IsMasterProtein" "Q15437" "Protein transport protein Sec23B OS=Homo sapiens OX=9606 GN=SEC23B PE=1 SV=2" "0.000" "False" "83.282" "26" "17" "31" "14" "767" "86.4" "6.89" "115.72" "17" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10483" "ENSG00000101310" "SEC23B" "D3DW33; hsa:10483; Q15437; Q503A9; Q5W183; Q9BS15; Q9BSI2; Q9H1D7" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "1.040" "1.058" "0.994" "1.074" "1.060" "1.049" "1.062" "1.137" "0.995" "1585.1" "1649.3" "1677.6" "1575.4" "1702.8" "1679.6" "1663.5" "1683.3" "1802.6" "1577.7" "" "" "" "" "" "" "" "" "" "" "1425.2" "1334.5" "1517.4" "1537.9" "1405.2" "1679.6" "1245.6" "1486.8" "1613.0" "563.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181785604482644820" "False" "High" "IsMasterProtein" "Q9NR50" "Translation initiation factor eIF2B subunit gamma OS=Homo sapiens OX=9606 GN=EIF2B3 PE=1 SV=1" "0.000" "False" "83.130" "48" "17" "24" "17" "452" "50.2" "6.47" "97.66" "17" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00483" "8891" "ENSG00000070785" "EIF2B3" "B2RBH8; D3DPZ2; hsa:8891; Q5QP89; Q5QP90; Q8NDB5; Q8WV57; Q9H850; Q9NR50" "Translation factors; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "3" "0" "0.997" "0.992" "0.995" "0.996" "0.992" "1.001" "0.992" "1.018" "0.941" "2218.2" "2212.5" "2200.5" "2207.0" "2209.1" "2201.4" "2219.9" "2201.4" "2257.1" "2088.2" "" "" "" "" "" "" "" "" "" "" "1994.4" "1790.3" "1990.5" "2154.4" "1823.0" "2201.4" "1662.2" "1944.4" "2019.6" "745.4" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4048246386295190521" "False" "High" "IsMasterProtein" "Q9Y6E0" "Serine/threonine-protein kinase 24 OS=Homo sapiens OX=9606 GN=STK24 PE=1 SV=1" "0.000" "False" "83.106" "35" "14" "35" "7" "443" "49.3" "5.69" "135.99" "14" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "8428" "ENSG00000102572" "STK24" "hsa:8428; O14840; Q5JV92; Q9Y6E0" "" "Apoptotic cleavage of cellular proteins" "2" "5" "0.922" "0.975" "0.989" "0.972" "0.933" "0.994" "0.992" "0.980" "0.910" "2928.1" "2699.7" "2853.5" "2896.8" "2847.4" "2731.8" "2909.7" "2905.3" "2868.8" "2663.7" "" "" "" "" "" "" "" "" "" "" "2632.6" "2184.5" "2581.1" "2827.7" "2349.7" "2731.8" "2178.7" "2566.1" "2566.9" "950.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106198041571123129" "False" "High" "IsMasterProtein" "Q9UMS4" "Pre-mRNA-processing factor 19 OS=Homo sapiens OX=9606 GN=PRPF19 PE=1 SV=1" "0.000" "False" "83.089" "33" "12" "39" "12" "504" "55.1" "6.61" "153.27" "12" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04564, Pf08606" "27339" "ENSG00000110107" "PRPF19" "Q9UMS4" "" "Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex" "5" "0" "0.988" "0.970" "0.968" "1.012" "0.945" "0.989" "0.968" "0.965" "0.775" "2959.4" "2922.6" "2869.1" "2864.0" "2995.5" "2797.9" "2925.7" "2863.9" "2854.5" "2294.1" "" "" "" "" "" "" "" "" "" "" "2660.8" "2364.9" "2595.2" "2795.6" "2472.0" "2797.9" "2190.7" "2529.6" "2554.2" "818.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832137807520605002" "False" "High" "IsMasterProtein" "O60934" "Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1" "0.000" "False" "82.991" "33" "22" "28" "22" "754" "84.9" "6.90" "98.27" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00498, Pf00533, Pf08599, Pf16508" "4683" "ENSG00000104320" "NBN" "B2R626; B2RNC5; hsa:4683; O60672; O60934; Q32NF7; Q53FM6; Q63HR6; Q7LDM2" "miRNA regulation of DNA damage response; Homologous recombination; DDX1 as a regulatory component of the Drosha microprocessor; ATM signaling in development and disease ; Breast cancer pathway; DNA repair pathways, full network; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); HDR through MMEJ (alt-NHEJ); Sensing of DNA Double Strand Breaks" "29" "0" "0.995" "0.953" "0.957" "1.033" "0.974" "1.002" "0.981" "0.977" "1.236" "2249.5" "2238.2" "2143.8" "2153.4" "2324.8" "2190.0" "2253.4" "2206.3" "2196.9" "2780.4" "" "" "" "" "" "" "" "" "" "" "2022.5" "1811.0" "1939.2" "2102.0" "1918.5" "2190.0" "1687.3" "1948.7" "1965.8" "992.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8618924530113613764" "False" "High" "IsMasterProtein" "Q9UPT6" "C-Jun-amino-terminal kinase-interacting protein 3 OS=Homo sapiens OX=9606 GN=MAPK8IP3 PE=1 SV=3" "0.000" "False" "82.943" "20" "23" "25" "21" "1336" "147.4" "5.40" "90.49" "23" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf09744, Pf16471, Pf19056" "23162" "ENSG00000138834" "MAPK8IP3" "A2A2B3; A7E2B3; hsa:23162; Q96RY4; Q9H4I4; Q9H7P1; Q9NUG0; Q9UPT6" "MAPK signaling pathway" "" "1" "0" "1.056" "1.151" "0.989" "1.022" "1.105" "1.043" "1.030" "1.123" "1.045" "1326.0" "1400.5" "1526.4" "1311.8" "1355.5" "1465.9" "1383.0" "1365.9" "1488.9" "1385.6" "" "" "" "" "" "" "" "" "" "" "1192.2" "1133.3" "1380.7" "1280.5" "1118.6" "1465.9" "1035.5" "1206.5" "1332.3" "494.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749149961980637251" "False" "High" "IsMasterProtein" "P27361" "Mitogen-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPK3 PE=1 SV=4" "0.000" "False" "82.898" "45" "17" "38" "11" "379" "43.1" "6.74" "131.99" "17" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "5595" "ENSG00000102882" "MAPK3" "A8CZ58; B0LPG3; hsa:5595; P27361; Q8NHX1" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; PDGF pathway; Polycystic kidney disease pathway; S1P receptor signal transduction; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; MFAP5-mediated ovarian cancer cell motility and invasiveness; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; Bile acids synthesis and enterohepatic circulation ; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Regulatory circuits of the STAT3 signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; CAMKK2 pathway; Disruption of postsynaptic signaling by CNV; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; 2q11.2 copy number variation syndrome; Comprehensive IL-17A signaling; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; 8p23.1 copy number variation syndrome; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; Osteoarthritic chondrocyte hypertrophy; NPHP1 deletion syndrome; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Regulation of PTEN gene transcription; Interferon gamma signaling; RHO GTPases Activate NADPH Oxidases; ISG15 antiviral mechanism; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCGR3A-mediated phagocytosis; NPAS4 regulates expression of target genes; RHO GTPases Activate WASPs and WAVEs; Regulation of HSF1-mediated heat shock response; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); Oxidative Stress Induced Senescence; Signaling by NODAL; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Oncogene Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Growth hormone receptor signaling; Regulation of the apoptosome activity; Signal transduction by L1; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RUNX2 regulates osteoblast differentiation; RSK activation; Spry regulation of FGF signaling; Suppression of apoptosis; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; IFNG signaling activates MAPKs; RNA Polymerase I Promoter Opening; Signaling by Activin; Activation of the AP-1 family of transcription factors; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Signal attenuation; Gastrin-CREB signalling pathway via PKC and MAPK; ESR-mediated signaling; Negative feedback regulation of MAPK pathway; Advanced glycosylation endproduct receptor signaling; Nuclear events stimulated by ALK signaling in cancer; ERKs are inactivated; Signaling by MAP2K mutants" "178" "0" "1.028" "1.015" "0.972" "1.022" "0.970" "0.997" "0.997" "0.979" "1.067" "1368.9" "1406.8" "1389.5" "1330.1" "1398.8" "1327.5" "1364.3" "1364.2" "1339.9" "1460.8" "" "" "" "" "" "" "" "" "" "" "1230.7" "1138.4" "1256.9" "1298.4" "1154.3" "1327.5" "1021.6" "1205.0" "1199.0" "521.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5839197527488627088" "False" "High" "IsMasterProtein" "P09110" "3-ketoacyl-CoA thiolase, peroxisomal OS=Homo sapiens OX=9606 GN=ACAA1 PE=1 SV=2" "0.000" "False" "82.886" "40" "10" "25" "10" "424" "44.3" "8.44" "126.66" "10" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00108, Pf02803" "30" "ENSG00000060971" "ACAA1" "G5E935; hsa:30; P09110; Q96CA6" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Amino acid metabolism; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX)" "Neutrophil degranulation; TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of very long chain fatty acids" "11" "0" "1.031" "1.067" "0.983" "1.057" "1.076" "1.007" "1.051" "1.088" "0.769" "1708.8" "1761.6" "1822.9" "1680.1" "1806.3" "1838.1" "1720.7" "1796.3" "1859.4" "1314.0" "" "" "" "" "" "" "" "" "" "" "1536.4" "1425.4" "1648.8" "1640.0" "1490.6" "1838.1" "1288.4" "1586.6" "1663.8" "469.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-453379581051164535" "False" "High" "IsMasterProtein" "P30086" "Phosphatidylethanolamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PEBP1 PE=1 SV=3" "0.000" "False" "82.866" "63" "11" "58" "11" "187" "21.0" "7.53" "245.11" "11" "other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf01161" "5037" "ENSG00000089220" "PEBP1" "B2R4S1; hsa:5037; P30086" "Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "9" "0" "0.926" "0.926" "0.984" "0.931" "0.944" "0.919" "1.023" "0.942" "0.796" "7888.0" "7303.6" "7304.2" "7763.8" "7342.8" "7442.8" "7251.6" "8066.1" "7433.4" "6276.0" "" "" "" "" "" "" "" "" "" "" "7092.1" "5909.8" "6606.9" "7578.5" "6059.4" "7442.8" "5429.8" "7124.5" "6651.4" "2240.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "105236357953779316" "False" "High" "IsMasterProtein" "Q9H0R4" "Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=HDHD2 PE=1 SV=1" "0.000" "False" "82.800" "65" "11" "22" "11" "259" "28.5" "6.24" "106.40" "11" "other metabolic processes" "" "other molecular function" "Pf13242, Pf13344" "84064" "ENSG00000167220" "HDHD2" "A8K7T3; hsa:84064; Q96NV4; Q9H0R4" "" "" "0" "0" "1.045" "1.054" "0.996" "1.096" "1.029" "1.068" "1.028" "1.049" "0.754" "1901.5" "1986.7" "2003.9" "1893.1" "2084.7" "1955.8" "2031.7" "1955.1" "1995.5" "1433.4" "" "" "" "" "" "" "" "" "" "" "1709.6" "1607.6" "1812.6" "1848.0" "1720.3" "1955.8" "1521.3" "1726.9" "1785.6" "511.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971041458510100973" "False" "High" "IsMasterProtein" "P61201" "COP9 signalosome complex subunit 2 OS=Homo sapiens OX=9606 GN=COPS2 PE=1 SV=1" "0.000" "False" "82.558" "42" "17" "40" "17" "443" "51.6" "5.53" "147.68" "17" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01399" "9318" "ENSG00000166200" "COPS2" "hsa:9318; O88950; P61201; Q15647; Q6FGP4; Q9BY54; Q9R249; Q9UNI2; Q9UNQ5" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Neddylation; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "6" "0" "0.991" "0.976" "0.956" "1.006" "0.975" "1.019" "1.019" "0.979" "0.807" "3411.7" "3379.3" "3330.3" "3261.3" "3432.3" "3327.2" "3475.0" "3475.9" "3338.6" "2752.2" "" "" "" "" "" "" "" "" "" "" "3067.4" "2734.4" "3012.4" "3183.5" "2832.4" "3327.2" "2602.0" "3070.1" "2987.4" "982.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613471079569612470" "False" "High" "IsMasterProtein" "P14866" "Heterogeneous nuclear ribonucleoprotein L OS=Homo sapiens OX=9606 GN=HNRNPL PE=1 SV=2" "0.000" "False" "82.237" "29" "13" "40" "12" "589" "64.1" "8.22" "131.36" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "3191" "ENSG00000104824; ENSG00000282947" "HNRNPL" "A6ND69; A6NIT8; hsa:3191; P14866; Q9H3P3" "mRNA processing; Hippocampal synaptogenesis and neurogenesis" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "4" "0" "0.928" "0.973" "1.071" "0.951" "0.957" "0.998" "0.906" "0.924" "3.461" "2312.1" "2146.1" "2249.8" "2477.0" "2199.9" "2211.9" "2307.4" "2094.9" "2137.2" "8002.8" "" "" "" "" "" "" "" "" "" "" "2078.8" "1736.5" "2035.0" "2417.9" "1815.4" "2211.9" "1727.7" "1850.3" "1912.3" "2856.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1318153562653389017" "False" "High" "IsMasterProtein" "O43837" "Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3B PE=1 SV=2" "0.000" "False" "82.226" "52" "16" "38" "16" "385" "42.2" "8.46" "123.81" "16" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00180" "3420" "ENSG00000101365" "IDH3B" "B2RDR1; D3DVX2; D3DVX3; hsa:3420; O43837; O95106; Q5JXS8; Q9NQ06; Q9NQ07; Q9NUZ0; Q9UEX0; Q9UG99" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "2" "0" "1.019" "0.959" "1.015" "0.976" "0.968" "1.001" "1.010" "1.057" "0.971" "3155.0" "3215.1" "3025.0" "3203.1" "3078.4" "3053.5" "3158.7" "3187.2" "3336.2" "3062.4" "" "" "" "" "" "" "" "" "" "" "2836.6" "2601.6" "2736.2" "3126.7" "2540.4" "3053.5" "2365.2" "2815.2" "2985.2" "1093.2" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5364611794781451874" "False" "High" "IsMasterProtein" "P08575" "Receptor-type tyrosine-protein phosphatase C OS=Homo sapiens OX=9606 GN=PTPRC PE=1 SV=3" "0.000" "False" "82.138" "16" "18" "28" "18" "1306" "147.4" "6.15" "100.25" "18" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00041, Pf00102, Pf12453, Pf12567" "5788" "ENSG00000081237; ENSG00000262418" "PTPRC" "A0A0A0MT22; A8K7W6; hsa:5788; P08575; Q16614; Q9H0Y6; X6R433" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulatory circuits of the STAT3 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; EPO receptor signaling; Interferon type I signaling pathways" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Other semaphorin interactions" "9" "0" "0.974" "0.922" "1.025" "0.982" "0.892" "0.989" "0.983" "0.927" "0.795" "2155.8" "2100.6" "1988.1" "2209.1" "2118.0" "1922.5" "2131.3" "2119.7" "1999.4" "1714.4" "" "" "" "" "" "" "" "" "" "" "1938.2" "1699.7" "1798.3" "2156.4" "1747.8" "1922.5" "1595.9" "1872.2" "1789.0" "612.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3113703590403153606" "False" "High" "IsMasterProtein" "Q96EP5" "DAZ-associated protein 1 OS=Homo sapiens OX=9606 GN=DAZAP1 PE=1 SV=1" "0.000" "False" "82.132" "32" "10" "37" "10" "407" "43.4" "8.56" "174.95" "10" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "26528" "ENSG00000071626" "DAZAP1" "hsa:26528; Q96EP5; Q96MJ3; Q9NRR9" "" "" "0" "0" "1.037" "0.998" "1.081" "1.031" "0.962" "1.024" "1.050" "1.023" "0.751" "2177.9" "2257.8" "2174.2" "2354.5" "2245.8" "2094.1" "2229.5" "2287.1" "2228.9" "1636.5" "" "" "" "" "" "" "" "" "" "" "1958.1" "1827.0" "1966.6" "2298.3" "1853.3" "2094.1" "1669.4" "2020.1" "1994.4" "584.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4061147392346931585" "False" "High" "IsMasterProtein" "P61006" "Ras-related protein Rab-8A OS=Homo sapiens OX=9606 GN=RAB8A PE=1 SV=1" "0.000" "False" "82.071" "57" "14" "45" "6" "207" "23.7" "9.07" "163.48" "14" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "4218" "ENSG00000167461" "RAB8A" "B4DEK7; hsa:4218; P24407; P61006; Q6FHV5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape; Joubert syndrome" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of PLK1 Activity at G2/M Transition; Anchoring of the basal body to the plasma membrane; VxPx cargo-targeting to cilium; TBC/RABGAPs" "10" "7" "0.994" "0.987" "0.960" "0.980" "0.904" "0.960" "0.946" "0.986" "0.691" "4576.5" "4546.8" "4515.8" "4394.0" "4484.7" "4139.4" "4391.4" "4331.2" "4511.4" "3161.8" "" "" "" "" "" "" "" "" "" "" "4114.7" "3679.1" "4084.6" "4289.2" "3700.9" "4139.4" "3288.1" "3825.6" "4036.7" "1128.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7722253779426460975" "False" "High" "IsMasterProtein" "O00571" "ATP-dependent RNA helicase DDX3X OS=Homo sapiens OX=9606 GN=DDX3X PE=1 SV=3" "0.000" "False" "81.976" "31" "19" "31" "6" "662" "73.2" "7.18" "111.64" "19" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "1654" "ENSG00000215301" "DDX3X" "A8K538; B4E3E8; hsa:1654; O00571; O15536" "Novel intracellular components of RIG-I-like receptor pathway; Hepatitis B infection" "Neutrophil degranulation" "3" "8" "0.937" "0.947" "0.964" "0.862" "0.958" "0.989" "0.806" "0.969" "5.433" "2343.3" "2195.8" "2220.0" "2258.1" "2020.0" "2244.7" "2318.4" "1889.8" "2271.5" "12730.4" "" "" "" "" "" "" "" "" "" "" "2106.8" "1776.8" "2008.1" "2204.2" "1666.9" "2244.7" "1736.0" "1669.2" "2032.5" "4544.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5588804604694799714" "False" "High" "IsMasterProtein" "P36957" "Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLST PE=1 SV=4" "0.000" "False" "81.934" "42" "15" "39" "15" "453" "48.7" "8.95" "150.76" "15" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00198, Pf00364" "1743" "ENSG00000119689" "DLST" "B7Z5W8; E7ESY5; hsa:1743; P36957; Q7LDY7; Q9BQ32" "TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Metabolic reprogramming in colon cancer; 7q11.23 copy number variation syndrome; 1p36 copy number variation syndrome; 10q11.21q11.23 copy number variation syndrome; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Lysine catabolism; Glyoxylate metabolism and glycine degradation" "10" "0" "1.006" "1.022" "1.061" "1.069" "1.005" "1.017" "0.990" "1.031" "0.910" "3188.3" "3206.4" "3258.4" "3382.5" "3409.2" "3203.6" "3241.7" "3155.9" "3286.5" "2901.5" "" "" "" "" "" "" "" "" "" "" "2866.6" "2594.5" "2947.4" "3301.8" "2813.4" "3203.6" "2427.3" "2787.5" "2940.7" "1035.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "875070389354990237" "False" "High" "IsMasterProtein" "O00273" "DNA fragmentation factor subunit alpha OS=Homo sapiens OX=9606 GN=DFFA PE=1 SV=1" "0.000" "False" "81.848" "51" "13" "27" "13" "331" "36.5" "4.79" "116.19" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02017, Pf09033" "1676" "ENSG00000160049" "DFFA" "hsa:1676; O00273; Q5T6G5; Q5T6G6; Q96I97; Q9Y6C6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "0.974" "1.005" "0.969" "1.080" "1.002" "1.019" "1.041" "1.041" "0.850" "2260.7" "2201.4" "2272.6" "2190.1" "2441.3" "2266.2" "2303.7" "2353.7" "2353.0" "1920.9" "" "" "" "" "" "" "" "" "" "" "2032.6" "1781.3" "2055.6" "2137.9" "2014.6" "2266.2" "1725.0" "2078.9" "2105.4" "685.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9199223731198630068" "False" "High" "IsMasterProtein" "Q9UIJ7" "GTP:AMP phosphotransferase AK3, mitochondrial OS=Homo sapiens OX=9606 GN=AK3 PE=1 SV=4" "0.000" "False" "81.744" "69" "16" "36" "16" "227" "25.6" "9.16" "131.54" "16" "other metabolic processes;stress response" "mitochondrion;other cell component" "kinase activity;other molecular function" "Pf00406, Pf05191" "50808" "ENSG00000147853" "AK3" "B4DP58; D3DRI1; E7ET30; hsa:50808; Q5VYW6; Q9H576; Q9HC01; Q9NPB4; Q9UIJ7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "0.964" "1.049" "1.001" "1.029" "1.064" "0.993" "1.029" "1.034" "0.830" "3721.6" "3588.2" "3904.6" "3725.7" "3831.0" "3958.7" "3696.0" "3830.3" "3846.4" "3090.6" "" "" "" "" "" "" "" "" "" "" "3346.1" "2903.5" "3531.8" "3636.8" "3161.4" "3958.7" "2767.5" "3383.2" "3441.8" "1103.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625236690753071245" "False" "High" "IsMasterProtein" "P22061" "Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Homo sapiens OX=9606 GN=PCMT1 PE=1 SV=4" "0.000" "False" "81.737" "51" "13" "44" "13" "227" "24.6" "7.21" "169.61" "13" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01135" "5110" "ENSG00000120265" "PCMT1" "A8K109; hsa:5110; J3KP72; P22061; Q14661; Q16556; Q5VYC1; Q5VYC2; Q93061; Q96II9; Q99625; Q9BQV7; Q9BQV8; Q9NP03" "Primary ovarian insufficiency" "Protein repair" "2" "0" "1.038" "1.023" "1.045" "1.020" "1.047" "1.070" "1.031" "1.032" "0.792" "3386.2" "3515.3" "3462.9" "3537.2" "3453.2" "3545.0" "3622.8" "3491.0" "3495.8" "2683.0" "" "" "" "" "" "" "" "" "" "" "3044.5" "2844.5" "3132.3" "3452.8" "2849.6" "3545.0" "2712.7" "3083.5" "3128.0" "957.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5704352961259904218" "False" "High" "IsMasterProtein" "Q14155" "Rho guanine nucleotide exchange factor 7 OS=Homo sapiens OX=9606 GN=ARHGEF7 PE=1 SV=2" "0.000" "False" "81.684" "23" "16" "32" "14" "803" "90.0" "7.09" "123.27" "16" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16614, Pf16615" "8874" "ENSG00000102606" "ARHGEF7" "B1ALK6; B1ALK8; hsa:8874; Q14155; Q3LIA4; Q5W9H0; Q6P9G3; Q6PII2; Q86W63; Q8N3M1" "Integrin-mediated cell adhesion; CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOV GTPase cycle; RHOU GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOJ GTPase cycle; Ephrin signaling; RHOQ GTPase cycle; EGFR downregulation" "14" "2" "1.019" "0.943" "0.972" "1.027" "0.945" "1.008" "1.006" "0.959" "1.014" "2556.3" "2605.2" "2410.1" "2485.7" "2624.7" "2415.3" "2576.4" "2570.8" "2452.6" "2593.0" "" "" "" "" "" "" "" "" "" "" "2298.4" "2108.1" "2180.0" "2426.4" "2166.0" "2415.3" "1929.2" "2270.7" "2194.6" "925.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2309568012740462624" "False" "High" "IsMasterProtein" "Q02750" "Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP2K1 PE=1 SV=2" "0.000" "False" "81.675" "43" "16" "36" "9" "393" "43.4" "6.62" "134.76" "16" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5604" "ENSG00000169032" "MAP2K1" "hsa:5604; Q02750" "IL-5 signaling pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Endothelin pathways; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Aryl hydrocarbon receptor pathway; Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAP3K8 (TPL2)-dependent MAPK1/3 activation; MAPK3 (ERK1) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "102" "0" "1.056" "1.030" "1.130" "1.031" "1.156" "1.072" "1.050" "1.094" "0.889" "1665.9" "1759.2" "1716.1" "1882.5" "1717.6" "1926.3" "1786.0" "1749.6" "1821.9" "1481.0" "" "" "" "" "" "" "" "" "" "" "1497.8" "1423.5" "1552.2" "1837.6" "1417.4" "1926.3" "1337.3" "1545.4" "1630.2" "528.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6717857941727919032" "False" "High" "IsMasterProtein" "Q8WZA9" "Immunity-related GTPase family Q protein OS=Homo sapiens OX=9606 GN=IRGQ PE=1 SV=1" "0.000" "False" "81.623" "35" "17" "27" "17" "623" "62.7" "4.88" "109.96" "17" "" "" "other molecular function" "" "126298" "ENSG00000167378" "IRGQ" "B2RNP3; hsa:126298; Q8WZA9" "" "" "0" "0" "1.084" "1.044" "1.030" "1.106" "1.089" "1.078" "1.076" "1.075" "0.948" "1690.5" "1832.6" "1764.9" "1740.4" "1870.3" "1841.6" "1823.1" "1819.4" "1818.1" "1602.9" "" "" "" "" "" "" "" "" "" "" "1519.9" "1482.9" "1596.4" "1698.8" "1543.4" "1841.6" "1365.1" "1607.0" "1626.8" "572.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1310996743308863221" "False" "High" "IsMasterProtein" "Q9Y3A5" "Ribosome maturation protein SBDS OS=Homo sapiens OX=9606 GN=SBDS PE=1 SV=4" "0.000" "False" "81.611" "64" "19" "32" "19" "250" "28.7" "8.75" "116.80" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity" "Pf01172, Pf09377, Pf20268" "51119" "ENSG00000126524" "SBDS" "A8K0P4; Q96FX0; Q9NV53; Q9Y3A5" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "0.995" "1.042" "1.013" "0.978" "1.020" "1.019" "0.960" "1.018" "1.125" "4079.4" "4057.4" "4249.2" "4132.5" "3989.6" "4161.7" "4158.4" "3914.7" "4153.7" "4588.7" "" "" "" "" "" "" "" "" "" "" "3667.8" "3283.1" "3843.5" "4033.9" "3292.3" "4161.7" "3113.7" "3457.7" "3716.7" "1638.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833035186099414895" "False" "High" "IsMasterProtein" "Q96KR1" "Zinc finger RNA-binding protein OS=Homo sapiens OX=9606 GN=ZFR PE=1 SV=2" "0.000" "False" "81.597" "17" "17" "31" "17" "1074" "116.9" "9.04" "102.19" "17" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07528, Pf12874, Pf20965" "51663" "ENSG00000056097" "ZFR" "B2RNR5; hsa:51663; Q05C08; Q3B7X5; Q6P5A3; Q86UA0; Q96KR1; Q9H6V4; Q9NTI1; Q9Y687" "Exercise-induced circadian regulation" "" "1" "0" "0.950" "0.962" "0.897" "0.953" "1.006" "0.928" "0.894" "0.914" "1.012" "3298.0" "3131.8" "3173.2" "2959.6" "3143.0" "3318.9" "3059.8" "2949.0" "3014.3" "3337.6" "" "" "" "" "" "" "" "" "" "" "2965.3" "2534.1" "2870.3" "2889.0" "2593.7" "3318.9" "2291.1" "2604.8" "2697.2" "1191.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3142486401368971215" "False" "High" "IsMasterProtein" "Q3YEC7" "Rab-like protein 6 OS=Homo sapiens OX=9606 GN=RABL6 PE=1 SV=2" "0.000" "False" "81.579" "27" "16" "30" "16" "729" "79.5" "5.22" "112.26" "16" "" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08477" "55684" "ENSG00000196642" "RABL6" "A8QVZ7; A8QVZ8; C6K8I4; C6K8I5; hsa:55684; Q3YEC7; Q4F968; Q5T5R7; Q8IWK1; Q8TCL4; Q8WU94; Q96SR8; Q9BU21; Q9H935" "" "" "0" "0" "1.023" "1.029" "1.007" "1.051" "1.020" "1.001" "1.001" "1.046" "0.942" "1902.0" "1946.3" "1956.5" "1916.2" "1998.6" "1940.9" "1903.5" "1904.7" "1990.2" "1791.1" "" "" "" "" "" "" "" "" "" "" "1710.1" "1574.9" "1769.7" "1870.5" "1649.2" "1940.9" "1425.3" "1682.4" "1780.8" "639.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1626409123411173154" "False" "High" "IsMasterProtein" "Q99598" "Translin-associated protein X OS=Homo sapiens OX=9606 GN=TSNAX PE=1 SV=1" "0.000" "False" "81.509" "52" "12" "30" "12" "290" "33.1" "6.55" "115.03" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01997" "7257" "ENSG00000116918" "TSNAX" "B1APC6; hsa:7257; Q99598" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.011" "1.006" "1.023" "1.081" "1.007" "1.060" "1.075" "1.060" "0.804" "2590.6" "2618.6" "2606.5" "2651.1" "2800.9" "2608.1" "2746.9" "2785.6" "2746.2" "2082.9" "" "" "" "" "" "" "" "" "" "" "2329.2" "2118.9" "2357.7" "2587.9" "2311.3" "2608.1" "2056.8" "2460.4" "2457.2" "743.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "556799029181218119" "False" "High" "IsMasterProtein" "Q13596" "Sorting nexin-1 OS=Homo sapiens OX=9606 GN=SNX1 PE=1 SV=3" "0.000" "False" "81.354" "29" "14" "27" "12" "522" "59.0" "5.15" "106.97" "14" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf03700, Pf09325" "6642" "ENSG00000028528" "SNX1" "A6NM19; A8K6T7; H0Y2M5; hsa:6642; O60750; O60751; Q13596; Q6ZRJ8" "" "" "0" "0" "0.883" "0.907" "1.029" "0.928" "0.872" "1.065" "0.854" "0.845" "1.989" "1522.5" "1343.9" "1381.0" "1566.6" "1412.3" "1327.1" "1622.0" "1299.9" "1286.1" "3028.2" "" "" "" "" "" "" "" "" "" "" "1368.9" "1087.4" "1249.1" "1529.3" "1165.4" "1327.1" "1214.5" "1148.1" "1150.8" "1081.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5381217781487520932" "False" "High" "IsMasterProtein" "Q99536" "Synaptic vesicle membrane protein VAT-1 homolog OS=Homo sapiens OX=9606 GN=VAT1 PE=1 SV=2" "0.000" "False" "81.333" "41" "11" "28" "11" "393" "41.9" "6.29" "113.05" "11" "other biological processes" "non-structural extracellular;other membranes;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf08240, Pf13602" "10493" "ENSG00000108828" "VAT1" "A8K345; B0AZP7; B4DPX4; hsa:10493; Q13035; Q5BKZ7; Q96A39; Q99536; Q9BUT8" "" "Neutrophil degranulation" "1" "0" "1.015" "1.010" "0.989" "1.028" "1.018" "1.010" "1.007" "1.009" "0.796" "2602.9" "2641.0" "2629.9" "2574.9" "2676.2" "2649.2" "2627.7" "2621.9" "2626.9" "2073.1" "" "" "" "" "" "" "" "" "" "" "2340.3" "2137.0" "2378.8" "2513.5" "2208.5" "2649.2" "1967.6" "2315.8" "2350.5" "740.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7525494529212049263" "False" "High" "IsMasterProtein" "O43149" "Zinc finger ZZ-type and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZZEF1 PE=1 SV=6" "0.000" "False" "81.244" "10" "26" "33" "26" "2961" "330.9" "5.95" "116.38" "26" "cell organization and biogenesis" "" "other molecular function" "Pf00569, Pf03256" "23140" "ENSG00000074755" "ZZEF1" "A7MBM5; hsa:23140; O43149; Q6NXG0; Q6ZRA1; Q6ZSF4; Q9NVB9" "" "" "0" "0" "0.994" "1.008" "0.970" "0.990" "0.989" "0.991" "0.982" "1.015" "0.955" "1889.8" "1879.0" "1905.2" "1833.4" "1870.5" "1869.0" "1873.4" "1856.4" "1917.7" "1805.7" "" "" "" "" "" "" "" "" "" "" "1699.1" "1520.4" "1723.4" "1789.6" "1543.6" "1869.0" "1402.8" "1639.7" "1715.9" "644.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5394846730023349610" "False" "High" "IsMasterProtein" "P55081" "Microfibrillar-associated protein 1 OS=Homo sapiens OX=9606 GN=MFAP1 PE=1 SV=2" "0.000" "False" "81.211" "45" "14" "27" "13" "439" "51.9" "4.98" "110.52" "14" "RNA metabolism OR transcription;other metabolic processes" "extracellular matrix;cytoskeleton;nucleus" "" "Pf06991" "4236" "ENSG00000140259" "MFAP1" "hsa:4236; P55081; Q86TG6" "Canonical and non-canonical Notch signaling; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "1" "1.014" "1.055" "0.983" "1.119" "1.094" "1.079" "1.092" "1.069" "0.495" "1623.3" "1645.7" "1713.0" "1596.4" "1817.2" "1775.6" "1750.9" "1772.4" "1734.8" "802.8" "" "" "" "" "" "" "" "" "" "" "1459.5" "1331.6" "1549.4" "1558.3" "1499.5" "1775.6" "1311.0" "1565.5" "1552.3" "286.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915222884888566270" "False" "High" "IsMasterProtein" "O15020" "Spectrin beta chain, non-erythrocytic 2 OS=Homo sapiens OX=9606 GN=SPTBN2 PE=1 SV=3" "0.000" "False" "81.186" "12" "25" "26" "23" "2390" "271.2" "6.11" "91.79" "25" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf15410" "6712" "ENSG00000173898" "SPTBN2" "hsa:6712; O14872; O14873; O15020" "" "MHC class II antigen presentation; COPI-mediated anterograde transport; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins" "5" "0" "1.017" "1.062" "0.996" "0.995" "1.051" "1.095" "0.937" "0.990" "1.742" "1264.4" "1285.4" "1342.1" "1259.3" "1257.6" "1329.0" "1384.1" "1184.7" "1251.5" "2202.7" "" "" "" "" "" "" "" "" "" "" "1136.8" "1040.1" "1214.0" "1229.2" "1037.8" "1329.0" "1036.4" "1046.4" "1119.8" "786.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3684476333316036577" "False" "High" "IsMasterProtein" "Q5R372" "Rab GTPase-activating protein 1-like OS=Homo sapiens OX=9606 GN=RABGAP1L PE=1 SV=1" "0.000" "False" "81.148" "25" "18" "30" "17" "815" "92.5" "5.31" "114.90" "18" "transport;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00566, Pf00640, Pf12473" "9910" "ENSG00000152061" "RABGAP1L" "O75059; Q3ZTR8; Q5R369; Q5R372; Q8IVV0; Q8N921; Q8WV78; Q9NSP8; Q9UQ19; Q9UQP5; Q9Y6Y5; Q9Y6Y6" "" "" "0" "0" "0.990" "0.968" "0.927" "1.003" "0.911" "0.954" "0.982" "0.958" "0.825" "2153.1" "2131.4" "2085.2" "1996.9" "2160.4" "1961.9" "2054.3" "2113.6" "2062.0" "1776.8" "" "" "" "" "" "" "" "" "" "" "1935.9" "1724.6" "1886.2" "1949.3" "1782.8" "1961.9" "1538.2" "1866.9" "1845.1" "634.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8925362845928829320" "False" "High" "IsMasterProtein" "Q12996" "Cleavage stimulation factor subunit 3 OS=Homo sapiens OX=9606 GN=CSTF3 PE=1 SV=1" "0.000" "False" "81.143" "32" "22" "33" "22" "717" "82.9" "8.12" "117.85" "22" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf05843" "1479" "ENSG00000176102" "CSTF3" "A8K471; D3DR04; E9PB40; hsa:1479; Q12996; Q32P22; Q96FQ8; Q96QD6; Q96QK4" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.052" "1.068" "0.993" "1.070" "1.077" "1.035" "1.000" "1.102" "0.822" "2749.4" "2891.3" "2935.0" "2730.5" "2942.3" "2962.2" "2844.4" "2748.9" "3029.8" "2260.5" "" "" "" "" "" "" "" "" "" "" "2472.0" "2339.6" "2654.8" "2665.3" "2428.0" "2962.2" "2129.8" "2428.0" "2711.1" "806.9" "21" "21" "21" "21" "21" "21" "21" "21" "21" "21" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2106414634070186016" "False" "High" "IsMasterProtein" "Q8WVM8" "Sec1 family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SCFD1 PE=1 SV=4" "0.000" "False" "81.126" "30" "17" "27" "17" "642" "72.3" "6.27" "104.44" "17" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00995" "23256" "ENSG00000092108" "SCFD1" "A8K2Z5; B7Z4U7; B7Z594; hsa:23256; O60754; O94990; Q7Z529; Q8WVM8; Q9BZI3; Q9UNL3; Q9Y6A8" "" "RHOA GTPase cycle; COPII-mediated vesicle transport" "2" "0" "0.992" "0.968" "1.083" "0.991" "0.938" "1.076" "0.973" "0.926" "1.065" "2604.6" "2584.3" "2520.5" "2820.3" "2581.2" "2442.4" "2803.4" "2534.6" "2411.8" "2773.5" "" "" "" "" "" "" "" "" "" "" "2341.8" "2091.1" "2279.9" "2753.0" "2130.1" "2442.4" "2099.1" "2238.8" "2158.1" "990.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951553745667677229" "False" "High" "IsMasterProtein" "P31689" "DnaJ homolog subfamily A member 1 OS=Homo sapiens OX=9606 GN=DNAJA1 PE=1 SV=2" "0.000" "False" "80.933" "43" "13" "34" "12" "397" "44.8" "7.08" "133.49" "13" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf00684, Pf01556" "3301" "ENSG00000086061" "DNAJA1" "hsa:3301; P31689; Q5T7Q0; Q86TL9" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; HDAC6 interactions in the central nervous system" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "4" "0" "0.973" "1.028" "1.040" "0.932" "1.081" "0.933" "1.002" "1.052" "1.230" "2553.2" "2484.5" "2623.7" "2655.1" "2379.5" "2761.2" "2383.3" "2557.5" "2685.2" "3139.6" "" "" "" "" "" "" "" "" "" "" "2295.6" "2010.4" "2373.2" "2591.8" "1963.6" "2761.2" "1784.6" "2259.0" "2402.7" "1120.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6534553132144552728" "False" "High" "IsMasterProtein" "Q09028" "Histone-binding protein RBBP4 OS=Homo sapiens OX=9606 GN=RBBP4 PE=1 SV=3" "0.000" "False" "80.912" "38" "13" "50" "7" "425" "47.6" "4.89" "190.28" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5928" "ENSG00000162521" "RBBP4" "B2R6G9; B4DRH0; D3DPQ3; hsa:5928; P31149; Q09028; Q53H02; Q96BV9" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; Effect of progerin on genes involved in progeria; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "RNA Polymerase I Transcription Initiation; HCMV Early Events; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Polo-like kinase mediated events; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "28" "0" "1.001" "0.998" "1.008" "1.048" "1.025" "1.115" "1.014" "1.055" "0.922" "3568.4" "3573.3" "3559.7" "3597.3" "3739.3" "3658.2" "3977.8" "3619.0" "3763.4" "3289.9" "" "" "" "" "" "" "" "" "" "" "3208.3" "2891.4" "3219.8" "3511.4" "3085.7" "3658.2" "2978.5" "3196.5" "3367.5" "1174.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8985233522455606046" "False" "High" "IsMasterProtein" "P61758" "Prefoldin subunit 3 OS=Homo sapiens OX=9606 GN=VBP1 PE=1 SV=4" "0.000" "False" "80.804" "62" "14" "62" "14" "197" "22.6" "7.11" "213.17" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "7411" "ENSG00000155959" "VBP1" "B2R8L5; B4DWR3; F5H2A7; hsa:7411; O55228; P61758; Q15765; Q5JT81; Q86X96" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.936" "0.932" "0.939" "0.964" "0.949" "0.959" "0.988" "0.984" "0.766" "6451.9" "6039.2" "6013.8" "6057.6" "6222.2" "6121.4" "6184.7" "6373.3" "6348.0" "4941.0" "" "" "" "" "" "" "" "" "" "" "5800.8" "4886.7" "5439.7" "5913.0" "5134.6" "6121.4" "4631.0" "5629.3" "5680.2" "1763.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2439136335340173205" "False" "High" "IsMasterProtein" "P22681" "E3 ubiquitin-protein ligase CBL OS=Homo sapiens OX=9606 GN=CBL PE=1 SV=2" "0.000" "False" "80.691" "24" "18" "26" "14" "906" "99.6" "6.54" "96.89" "18" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf00627, Pf02262, Pf02761, Pf02762" "867" "ENSG00000110395" "CBL" "A3KMP8; P22681" "RANKL/RANK signaling pathway; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; MET in type 1 papillary renal cell carcinoma; EGF/EGFR signaling pathway; Insulin signaling; IL-2 signaling pathway; 4p16.3 copy number variation; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "Signaling by CSF1 (M-CSF) in myeloid cells; Regulation of signaling by CBL; Regulation of KIT signaling; Negative regulation of FLT3; Cargo recognition for clathrin-mediated endocytosis; Interleukin-6 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Spry regulation of FGF signaling; TGF-beta receptor signaling activates SMADs; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; FLT3 signaling by CBL mutants" "39" "4" "1.036" "1.012" "0.971" "1.040" "1.039" "1.020" "1.033" "1.057" "0.821" "1815.6" "1880.5" "1837.5" "1763.0" "1887.7" "1885.5" "1852.1" "1875.0" "1918.8" "1489.9" "" "" "" "" "" "" "" "" "" "" "1632.4" "1521.6" "1662.1" "1720.9" "1557.7" "1885.5" "1386.8" "1656.1" "1716.9" "531.9" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-11749500110992675" "False" "High" "IsMasterProtein" "Q92995" "Ubiquitin carboxyl-terminal hydrolase 13 OS=Homo sapiens OX=9606 GN=USP13 PE=1 SV=2" "0.000" "False" "80.677" "26" "17" "26" "16" "863" "97.3" "5.53" "102.23" "17" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf00627, Pf02148, Pf17807" "8975" "ENSG00000058056" "USP13" "A8K2S3; B4DYF3; D3DNS2; hsa:8975; Q92995; Q96B25" "" "Ub-specific processing proteases; Regulation of PTEN stability and activity" "2" "0" "1.000" "0.979" "0.924" "1.002" "0.938" "1.005" "0.947" "0.947" "1.203" "2156.8" "2155.8" "2111.2" "1992.5" "2160.9" "2022.1" "2168.5" "2043.5" "2042.8" "2595.1" "" "" "" "" "" "" "" "" "" "" "1939.2" "1744.4" "1909.7" "1945.0" "1783.2" "2022.1" "1623.7" "1805.0" "1827.9" "926.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7210504404319708374" "False" "High" "IsMasterProtein" "P33240" "Cleavage stimulation factor subunit 2 OS=Homo sapiens OX=9606 GN=CSTF2 PE=1 SV=1" "0.000" "False" "80.526" "33" "14" "26" "8" "577" "60.9" "6.83" "89.55" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf14304, Pf14327" "1478" "ENSG00000101811" "CSTF2" "hsa:1478; P33240; Q5H951; Q6LA74; Q8N502" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "0.931" "0.999" "0.966" "1.073" "1.023" "0.988" "1.025" "1.017" "0.960" "519.6" "483.7" "519.3" "501.7" "557.4" "531.4" "513.1" "532.6" "528.6" "498.9" "" "" "" "" "" "" "" "" "" "" "467.1" "391.4" "469.7" "489.7" "460.0" "531.4" "384.2" "470.4" "473.0" "178.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5185588165699995097" "False" "High" "IsMasterProtein" "P20290" "Transcription factor BTF3 OS=Homo sapiens OX=9606 GN=BTF3 PE=1 SV=1" "0.000" "False" "80.493" "63" "13" "39" "11" "206" "22.2" "9.38" "153.05" "13" "transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "" "Pf01849" "689" "ENSG00000145741" "BTF3" "A8K510; hsa:689; P20290; Q13893; Q76M56" "Orexin receptor pathway" "" "1" "2" "0.979" "1.009" "1.047" "0.981" "1.073" "1.019" "1.120" "0.978" "0.847" "3683.8" "3608.0" "3716.6" "3858.0" "3614.8" "3952.1" "3755.1" "4124.1" "3601.6" "3121.2" "" "" "" "" "" "" "" "" "" "" "3312.1" "2919.5" "3361.8" "3765.9" "2983.0" "3952.1" "2811.7" "3642.7" "3222.7" "1114.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8500687369034294287" "False" "High" "IsMasterProtein" "P62820" "Ras-related protein Rab-1A OS=Homo sapiens OX=9606 GN=RAB1A PE=1 SV=3" "0.000" "False" "80.492" "75" "14" "49" "6" "205" "22.7" "6.21" "169.41" "14" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5861" "ENSG00000138069" "RAB1A" "hsa:5861; P11476; P62820; Q6FIE7; Q96N61; Q9Y3T2" "" "RAB GEFs exchange GTP for GDP on RABs; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "4" "0.992" "0.972" "0.984" "0.948" "0.924" "0.972" "0.970" "0.955" "0.693" "3358.5" "3332.8" "3263.9" "3304.9" "3182.9" "3102.0" "3265.7" "3258.7" "3207.2" "2327.4" "" "" "" "" "" "" "" "" "" "" "3019.6" "2696.8" "2952.3" "3226.1" "2626.6" "3102.0" "2445.3" "2878.3" "2869.8" "830.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9116145290149312693" "False" "High" "IsMasterProtein" "P42226" "Signal transducer and activator of transcription 6 OS=Homo sapiens OX=9606 GN=STAT6 PE=1 SV=1" "0.000" "False" "80.404" "22" "18" "28" "18" "847" "94.1" "6.23" "94.86" "18" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf14596, Pf21354" "6778" "ENSG00000166888" "STAT6" "A8K316; B7ZA27; F5GXI9; hsa:6778; P42226; Q5FBW5; Q71UP4" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Adipogenesis; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; PDGFR-beta pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neuroinflammation and glutamatergic signaling; Th17 cell differentiation pathway; Inflammatory bowel disease signaling; IL-19 signaling pathway" "Downstream signal transduction; Interleukin-4 and Interleukin-13 signaling; STAT6-mediated induction of chemokines" "13" "0" "1.055" "1.073" "0.982" "1.070" "1.063" "1.070" "1.055" "1.098" "1.451" "2162.4" "2281.2" "2319.6" "2122.9" "2314.7" "2298.5" "2314.8" "2282.3" "2373.9" "3137.4" "" "" "" "" "" "" "" "" "" "" "1944.2" "1845.9" "2098.2" "2072.3" "1910.1" "2298.5" "1733.2" "2015.8" "2124.1" "1120.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "906200433272310872" "False" "High" "IsMasterProtein" "Q8NBS9" "Thioredoxin domain-containing protein 5 OS=Homo sapiens OX=9606 GN=TXNDC5 PE=1 SV=2" "0.000" "False" "80.249" "43" "16" "38" "16" "432" "47.6" "5.97" "152.65" "16" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00085" "81567" "ENSG00000239264" "TXNDC5" "B2RDM2; hsa:81567; Q5TCQ0; Q8NBS9; Q8ND33; Q8TCT2; Q9BVH9" "VEGFA-VEGFR2 signaling" "Golgi Associated Vesicle Biogenesis; Neutrophil degranulation; Lysosome Vesicle Biogenesis" "4" "0" "0.984" "0.983" "1.009" "1.029" "0.942" "0.972" "0.996" "0.992" "0.729" "2796.2" "2751.0" "2747.5" "2821.9" "2877.5" "2634.8" "2718.7" "2783.7" "2774.8" "2039.5" "" "" "" "" "" "" "" "" "" "" "2514.1" "2226.0" "2485.2" "2754.6" "2374.6" "2634.8" "2035.7" "2458.8" "2482.9" "728.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8506961570143965113" "False" "High" "IsMasterProtein" "Q99497" "Parkinson disease protein 7 OS=Homo sapiens OX=9606 GN=PARK7 PE=1 SV=2" "0.000" "False" "79.998" "54" "10" "47" "10" "189" "19.9" "6.79" "183.28" "10" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01965" "11315" "ENSG00000116288" "PARK7" "B2R4Z1; hsa:11315; O14805; Q6DR95; Q7LFU2; Q99497" "Androgen receptor signaling pathway; Synaptic vesicle pathway; Parkinson's disease pathway; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Aggrephagy; SUMOylation of transcription cofactors; Chaperone Mediated Autophagy" "8" "0" "0.999" "0.931" "1.038" "0.943" "1.056" "0.979" "1.009" "1.006" "0.774" "4505.2" "4502.0" "4196.6" "4675.5" "4247.8" "4756.8" "4412.2" "4544.3" "4531.5" "3486.0" "" "" "" "" "" "" "" "" "" "" "4050.6" "3642.9" "3796.0" "4563.9" "3505.3" "4756.8" "3303.7" "4013.8" "4054.8" "1244.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7454062146017555339" "False" "High" "IsMasterProtein" "P32019" "Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=4" "0.000" "False" "79.978" "20" "19" "26" "19" "993" "112.8" "5.57" "87.59" "19" "other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00620, Pf16776, Pf21310" "3633" "ENSG00000204084" "INPP5B" "C9J6U5; hsa:3633; P32019; Q5VSG9; Q5VSH0; Q5VSH1; Q658Q5; Q6P6D4; Q6PD53; Q86YE1" "" "Synthesis of IP2, IP, and Ins in the cytosol; Synthesis of IP3 and IP4 in the cytosol" "2" "0" "1.014" "0.996" "0.956" "1.010" "0.941" "0.999" "0.942" "0.970" "1.032" "2373.6" "2405.8" "2363.9" "2269.2" "2397.3" "2234.0" "2370.1" "2236.2" "2301.7" "2448.4" "" "" "" "" "" "" "" "" "" "" "2134.1" "1946.7" "2138.2" "2215.1" "1978.3" "2234.0" "1774.6" "1975.1" "2059.6" "874.0" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9201428938326541883" "False" "High" "IsMasterProtein" "Q15291" "Retinoblastoma-binding protein 5 OS=Homo sapiens OX=9606 GN=RBBP5 PE=1 SV=2" "0.000" "False" "79.945" "30" "15" "30" "15" "538" "59.1" "5.10" "110.60" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00400" "5929" "ENSG00000117222" "RBBP5" "A8K272; hsa:5929; Q15291; Q7Z6D8; Q8NDZ7" "Kleefstra syndrome" "Neddylation; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "1.059" "1.149" "1.037" "1.056" "1.144" "0.995" "1.016" "1.180" "0.947" "1590.1" "1683.4" "1827.6" "1649.2" "1678.4" "1819.3" "1582.4" "1614.9" "1876.3" "1505.1" "" "" "" "" "" "" "" "" "" "" "1429.6" "1362.2" "1653.1" "1609.8" "1385.0" "1819.3" "1184.9" "1426.4" "1678.9" "537.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5379927886480691395" "False" "High" "IsMasterProtein" "O95456" "Proteasome assembly chaperone 1 OS=Homo sapiens OX=9606 GN=PSMG1 PE=1 SV=1" "0.000" "False" "79.878" "67" "16" "37" "16" "288" "32.8" "7.17" "136.60" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf16094" "8624" "ENSG00000183527" "PSMG1" "B5BUN2; hsa:8624; O95456; Q6FHA3; Q6FHD3; Q6S713" "" "" "0" "0" "1.065" "1.095" "1.058" "1.040" "1.046" "1.072" "1.045" "1.072" "0.839" "2597.7" "2766.4" "2845.6" "2748.5" "2700.8" "2718.4" "2784.8" "2714.2" "2783.6" "2179.0" "" "" "" "" "" "" "" "" "" "" "2335.6" "2238.4" "2573.9" "2683.0" "2228.8" "2718.4" "2085.2" "2397.4" "2490.7" "777.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167076474534668157" "False" "High" "IsMasterProtein" "Q15398" "Disks large-associated protein 5 OS=Homo sapiens OX=9606 GN=DLGAP5 PE=1 SV=2" "0.000" "False" "79.826" "28" "22" "28" "22" "846" "95.1" "9.00" "94.78" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf03359" "9787" "ENSG00000126787" "DLGAP5" "A8MTM6; B4DRM8; hsa:9787; Q15398; Q86T11; Q8NG58" "Complement system in neuronal development and plasticity" "NOTCH3 Intracellular Domain Regulates Transcription" "2" "0" "1.071" "1.192" "1.011" "1.073" "1.148" "1.162" "1.018" "1.112" "1.895" "1578.5" "1690.4" "1881.8" "1596.1" "1694.4" "1811.8" "1834.6" "1607.5" "1754.9" "2990.6" "" "" "" "" "" "" "" "" "" "" "1419.3" "1367.8" "1702.2" "1558.0" "1398.3" "1811.8" "1373.7" "1419.8" "1570.3" "1067.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5797798922783167285" "False" "High" "IsMasterProtein" "Q2TAY7" "WD40 repeat-containing protein SMU1 OS=Homo sapiens OX=9606 GN=SMU1 PE=1 SV=2" "0.000" "False" "79.403" "42" "17" "24" "17" "513" "57.5" "7.18" "91.81" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf17814" "55234" "ENSG00000122692" "SMU1" "B4E3L0; hsa:55234; Q2TAY7; Q9BU59; Q9HA96; Q9NVD1" "" "mRNA Splicing - Major Pathway" "1" "0" "1.111" "1.134" "1.004" "1.091" "1.121" "1.086" "1.054" "1.128" "0.861" "1476.6" "1640.1" "1674.6" "1481.8" "1611.6" "1655.3" "1604.0" "1555.9" "1666.2" "1271.8" "" "" "" "" "" "" "" "" "" "" "1327.6" "1327.1" "1514.8" "1446.4" "1329.9" "1655.3" "1201.1" "1374.3" "1490.9" "454.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6550652705279003104" "False" "High" "IsMasterProtein" "P50552" "Vasodilator-stimulated phosphoprotein OS=Homo sapiens OX=9606 GN=VASP PE=1 SV=3" "0.000" "False" "79.360" "48" "16" "30" "16" "380" "39.8" "8.94" "105.78" "16" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "7408" "ENSG00000125753" "VASP" "B2RBT9; hsa:7408; P50552; Q6PIZ1; Q93035" "Integrin-mediated cell adhesion; Focal adhesion" "Generation of second messenger molecules; Signaling by ROBO receptors; Cell-extracellular matrix interactions" "5" "0" "0.965" "1.022" "1.037" "0.991" "1.090" "1.032" "1.061" "0.973" "1.226" "2542.3" "2453.4" "2598.4" "2635.4" "2519.0" "2770.5" "2624.2" "2698.3" "2472.6" "3117.9" "" "" "" "" "" "" "" "" "" "" "2285.8" "1985.2" "2350.3" "2572.5" "2078.7" "2770.5" "1964.9" "2383.4" "2212.4" "1113.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6956886752181187117" "False" "High" "IsMasterProtein" "P55039" "Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens OX=9606 GN=DRG2 PE=1 SV=1" "0.000" "False" "79.217" "46" "16" "31" "15" "364" "40.7" "8.88" "104.85" "16" "protein metabolism;other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01926, Pf02824, Pf16897" "1819" "ENSG00000108591" "DRG2" "B2R8G5; hsa:1819; P55039; Q53Y50; Q9BWB2" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Protein hydroxylation" "2" "0" "1.042" "1.023" "0.973" "1.032" "0.964" "1.010" "0.983" "1.031" "0.855" "2633.1" "2744.9" "2692.5" "2562.7" "2716.8" "2537.3" "2659.6" "2587.7" "2715.1" "2250.1" "" "" "" "" "" "" "" "" "" "" "2367.4" "2221.1" "2435.5" "2501.6" "2242.0" "2537.3" "1991.4" "2285.6" "2429.4" "803.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4007751392279359432" "False" "High" "IsMasterProtein" "Q562R1" "Beta-actin-like protein 2 OS=Homo sapiens OX=9606 GN=ACTBL2 PE=1 SV=2" "0.000" "False" "78.978" "34" "13" "419" "4" "376" "42.0" "5.59" "1357.10" "13" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "345651" "ENSG00000169067" "ACTBL2" "B2RPJ1; hsa:345651; Q562R1; Q562R2; Q562S9; Q562X8" "" "" "0" "0" "1.009" "1.022" "0.864" "0.846" "1.035" "0.730" "0.866" "0.970" "0.788" "437.6" "441.7" "447.3" "378.2" "370.0" "453.0" "319.3" "378.7" "424.6" "344.9" "" "" "" "" "" "" "" "" "" "" "393.4" "357.4" "404.6" "369.2" "305.3" "453.0" "239.1" "334.5" "379.9" "123.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7547854547274614235" "False" "High" "IsMasterProtein" "Q66K74" "Microtubule-associated protein 1S OS=Homo sapiens OX=9606 GN=MAP1S PE=1 SV=2" "0.000" "False" "78.937" "20" "15" "25" "15" "1059" "112.1" "7.30" "93.41" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "55201" "ENSG00000130479" "MAP1S" "B4DH53; hsa:55201; Q27QB1; Q66K74; Q6NXF1; Q8N3L8; Q8N3W5; Q8NI88; Q96H94; Q96IT4; Q96SP8; Q9BRC6; Q9H928; Q9NVK7" "" "" "0" "0" "1.016" "1.079" "1.051" "1.001" "1.075" "1.076" "1.043" "1.070" "1.012" "1377.7" "1399.9" "1486.7" "1448.5" "1379.2" "1481.4" "1482.8" "1437.5" "1473.8" "1393.9" "" "" "" "" "" "" "" "" "" "" "1238.6" "1132.7" "1344.8" "1414.0" "1138.2" "1481.4" "1110.3" "1269.7" "1318.7" "497.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7016247097338811422" "False" "High" "IsMasterProtein" "Q9NW64" "Pre-mRNA-splicing factor RBM22 OS=Homo sapiens OX=9606 GN=RBM22 PE=1 SV=1" "0.000" "False" "78.892" "38" "13" "30" "13" "420" "46.9" "8.54" "106.91" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf21369" "55696" "ENSG00000086589" "RBM22" "A6NDM5; B4DLI9; hsa:55696; O95607; Q9NW64" "" "mRNA Splicing - Major Pathway" "1" "0" "1.014" "1.050" "1.041" "1.006" "0.997" "0.975" "0.997" "1.027" "0.918" "2854.3" "2894.1" "2996.8" "2970.5" "2870.3" "2846.3" "2781.5" "2844.7" "2930.5" "2620.6" "" "" "" "" "" "" "" "" "" "" "2566.3" "2341.8" "2710.7" "2899.7" "2368.6" "2846.3" "2082.7" "2512.6" "2622.2" "935.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4996428185622591073" "False" "High" "IsMasterProtein" "Q9NZB2" "Constitutive coactivator of PPAR-gamma-like protein 1 OS=Homo sapiens OX=9606 GN=FAM120A PE=1 SV=2" "0.000" "False" "78.753" "20" "17" "22" "17" "1118" "121.8" "8.88" "100.68" "17" "" "plasma membrane;other membranes;cytosol;nucleus" "" "" "23196" "ENSG00000048828" "FAM120A" "A6NGU0; C4AMC6; hsa:23196; O60649; Q14688; Q4VXF4; Q4VXF5; Q4VXG2; Q86V69; Q96I21; Q9NZB1; Q9NZB2" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.995" "0.938" "0.890" "0.989" "1.033" "0.929" "0.924" "0.931" "1.149" "1739.9" "1731.2" "1632.6" "1549.1" "1720.6" "1797.3" "1616.7" "1608.1" "1619.4" "1999.9" "" "" "" "" "" "" "" "" "" "" "1564.3" "1400.9" "1476.7" "1512.1" "1419.9" "1797.3" "1210.6" "1420.4" "1449.0" "713.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286201540320348411" "False" "High" "IsMasterProtein" "Q92990" "Glomulin OS=Homo sapiens OX=9606 GN=GLMN PE=1 SV=2" "0.000" "False" "78.616" "32" "17" "34" "17" "594" "68.2" "5.33" "116.59" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf08568" "11146" "ENSG00000174842" "GLMN" "hsa:11146; Q5VVC3; Q92990; Q9BVE8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.003" "1.051" "0.984" "1.057" "1.034" "1.045" "1.043" "1.047" "0.890" "2541.7" "2549.2" "2671.6" "2500.1" "2687.7" "2629.1" "2656.3" "2651.1" "2660.7" "2262.2" "" "" "" "" "" "" "" "" "" "" "2285.3" "2062.7" "2416.6" "2440.5" "2217.9" "2629.1" "1988.9" "2341.6" "2380.8" "807.5" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1449875230825116072" "False" "High" "IsMasterProtein" "Q03252" "Lamin-B2 OS=Homo sapiens OX=9606 GN=LMNB2 PE=1 SV=4" "0.000" "False" "78.600" "30" "19" "26" "17" "620" "69.9" "5.59" "97.80" "19" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00038, Pf00932" "84823" "ENSG00000176619" "LMNB2" "hsa:84823; O75292; Q03252; Q14734; Q96DF6" "Gastric cancer network 2; Fas ligand pathway and stress induction of heat shock proteins; IL-18 signaling pathway; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "" "6" "0" "1.049" "0.868" "1.013" "1.102" "0.876" "1.164" "0.991" "0.857" "0.730" "1989.0" "2085.7" "1725.7" "2015.3" "2192.2" "1742.4" "2316.0" "1971.4" "1703.8" "1451.5" "" "" "" "" "" "" "" "" "" "" "1788.3" "1687.7" "1560.9" "1967.3" "1809.0" "1742.4" "1734.2" "1741.3" "1524.5" "518.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988285782465549683" "False" "High" "IsMasterProtein" "Q9NYB0" "Telomeric repeat-binding factor 2-interacting protein 1 OS=Homo sapiens OX=9606 GN=TERF2IP PE=1 SV=1" "0.000" "False" "78.532" "37" "15" "28" "15" "399" "44.2" "4.73" "109.38" "15" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08914, Pf11626, Pf16589" "54386" "ENSG00000166848" "TERF2IP" "B4DQN4; hsa:54386; Q4W4Y2; Q8WYZ3; Q9NWR2; Q9NYB0" "Splicing factor NOVA regulated synaptic proteins; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; Meiotic synapsis; Telomere Extension By Telomerase; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; Packaging Of Telomere Ends; DNA Damage/Telomere Stress Induced Senescence; Removal of the Flap Intermediate from the C-strand" "16" "0" "0.910" "0.881" "0.968" "0.981" "0.866" "0.976" "0.992" "0.890" "0.829" "3913.4" "3560.4" "3447.9" "3789.9" "3840.5" "3389.0" "3817.7" "3880.3" "3484.7" "3243.8" "" "" "" "" "" "" "" "" "" "" "3518.6" "2881.0" "3118.7" "3699.4" "3169.3" "3389.0" "2858.6" "3427.3" "3118.1" "1158.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5215357132518723376" "False" "High" "IsMasterProtein" "P30040" "Endoplasmic reticulum resident protein 29 OS=Homo sapiens OX=9606 GN=ERP29 PE=1 SV=4" "0.000" "False" "78.482" "49" "11" "37" "11" "261" "29.0" "7.31" "137.91" "11" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf07749, Pf07912" "10961" "ENSG00000089248" "ERP29" "C9J183; hsa:10961; P30040; Q3MJC3; Q6FHT4" "" "" "0" "0" "0.938" "0.956" "0.987" "0.980" "0.992" "0.966" "1.034" "1.015" "0.769" "4821.2" "4521.4" "4610.9" "4757.1" "4724.9" "4782.4" "4655.0" "4986.4" "4893.0" "3706.3" "" "" "" "" "" "" "" "" "" "" "4334.7" "3658.5" "4170.8" "4643.6" "3899.1" "4782.4" "3485.5" "4404.3" "4378.3" "1323.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6604733771635373365" "False" "High" "IsMasterProtein" "P84085" "ADP-ribosylation factor 5 OS=Homo sapiens OX=9606 GN=ARF5 PE=1 SV=2" "0.000" "False" "78.463" "68" "11" "51" "5" "180" "20.5" "6.79" "196.00" "11" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00025" "381" "ENSG00000004059" "ARF5" "hsa:381; P26437; P84085" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "3" "0" "1.044" "1.034" "0.983" "1.069" "1.056" "1.004" "0.978" "1.068" "0.862" "1998.6" "2086.6" "2066.8" "1964.8" "2136.0" "2111.1" "2006.5" "1953.7" "2133.7" "1722.7" "" "" "" "" "" "" "" "" "" "" "1797.0" "1688.4" "1869.5" "1918.0" "1762.7" "2111.1" "1502.4" "1725.7" "1909.3" "614.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664537344047956195" "False" "High" "IsMasterProtein" "Q08209" "Protein phosphatase 3 catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PPP3CA PE=1 SV=1" "0.000" "False" "78.405" "28" "13" "29" "8" "521" "58.7" "5.86" "109.82" "13" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5530" "ENSG00000138814" "PPP3CA" "A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2; hsa:5530; Q08209; Q8TAW9" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Serotonin and anxiety-related events; Serotonin and anxiety; Wnt signaling; Vitamin D in inflammatory diseases; Fragile X syndrome; Alzheimer's disease; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Ca2+ pathway; Calcineurin activates NFAT; DARPP-32 events" "26" "6" "1.041" "0.967" "1.053" "1.081" "0.995" "1.031" "1.031" "1.019" "0.877" "3159.6" "3288.4" "3055.7" "3328.5" "3415.4" "3145.0" "3257.5" "3256.4" "3221.2" "2772.5" "" "" "" "" "" "" "" "" "" "" "2840.8" "2660.8" "2764.0" "3249.1" "2818.4" "3145.0" "2439.1" "2876.2" "2882.3" "989.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3689472973843486022" "False" "High" "IsMasterProtein" "O00505" "Importin subunit alpha-4 OS=Homo sapiens OX=9606 GN=KPNA3 PE=1 SV=2" "0.000" "False" "78.364" "29" "11" "36" "8" "521" "57.8" "4.94" "148.80" "11" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3839" "ENSG00000102753" "KPNA3" "hsa:3839; O00191; O00505; O43195; Q5JVM9; Q8IYQ9; Q96AA7" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "2" "3" "0.957" "0.948" "0.919" "1.009" "0.909" "0.996" "0.972" "0.918" "1.136" "3922.0" "3754.4" "3719.8" "3602.5" "3958.4" "3566.5" "3906.7" "3813.5" "3601.0" "4456.6" "" "" "" "" "" "" "" "" "" "" "3526.3" "3038.0" "3364.7" "3516.6" "3266.6" "3566.5" "2925.3" "3368.4" "3222.1" "1590.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9177231757861531522" "False" "High" "IsMasterProtein" "P25685" "DnaJ homolog subfamily B member 1 OS=Homo sapiens OX=9606 GN=DNAJB1 PE=1 SV=4" "0.000" "False" "78.354" "51" "20" "35" "19" "340" "38.0" "8.63" "123.28" "20" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226, Pf01556" "3337" "ENSG00000132002" "DNAJB1" "B4DX52; hsa:3337; P25685" "Nuclear receptors meta-pathway; NRF2 pathway" "MAPK6/MAPK4 signaling; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Regulation of HSF1-mediated heat shock response; Attenuation phase" "7" "1" "1.057" "1.180" "1.034" "1.052" "1.168" "1.056" "1.074" "1.222" "1.537" "3276.4" "3464.4" "3866.8" "3387.2" "3447.3" "3827.4" "3459.0" "3519.6" "4003.1" "5036.1" "" "" "" "" "" "" "" "" "" "" "2945.8" "2803.2" "3497.6" "3306.4" "2844.8" "3827.4" "2590.0" "3108.7" "3582.0" "1797.8" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6652011194005899795" "False" "High" "IsMasterProtein" "P29083" "General transcription factor IIE subunit 1 OS=Homo sapiens OX=9606 GN=GTF2E1 PE=1 SV=2" "0.000" "False" "78.321" "50" "15" "30" "15" "439" "49.4" "4.82" "107.26" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02002, Pf08271, Pf11521" "2960" "ENSG00000153767" "GTF2E1" "hsa:2960; P29083; Q16103" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.990" "0.994" "0.975" "1.064" "0.972" "1.007" "1.008" "1.005" "0.971" "1034.7" "1024.0" "1028.4" "1009.1" "1101.2" "1005.8" "1041.7" "1042.8" "1039.4" "1004.8" "" "" "" "" "" "" "" "" "" "" "930.3" "828.6" "930.2" "985.0" "908.7" "1005.8" "780.0" "921.0" "930.1" "358.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864595288643475005" "False" "High" "IsMasterProtein" "P61011" "Signal recognition particle subunit SRP54 OS=Homo sapiens OX=9606 GN=SRP54 PE=1 SV=1" "0.000" "False" "78.223" "30" "14" "24" "14" "504" "55.7" "8.75" "92.58" "14" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00448, Pf02881, Pf02978" "6729" "ENSG00000100883" "SRP54" "B2R759; B4DUW6; hsa:6729; P13624; P61011" "VEGFA-VEGFR2 signaling; mRNA processing" "SRP-dependent cotranslational protein targeting to membrane" "3" "0" "1.048" "0.936" "0.945" "0.995" "0.938" "0.990" "0.953" "0.927" "0.835" "1979.0" "2074.3" "1851.5" "1869.5" "1969.7" "1855.7" "1959.9" "1885.3" "1835.3" "1653.2" "" "" "" "" "" "" "" "" "" "" "1779.3" "1678.5" "1674.7" "1824.9" "1625.4" "1855.7" "1467.5" "1665.2" "1642.2" "590.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6222929657638767461" "False" "High" "IsMasterProtein" "P23284" "Peptidyl-prolyl cis-trans isomerase B OS=Homo sapiens OX=9606 GN=PPIB PE=1 SV=2" "0.000" "False" "78.172" "54" "12" "70" "11" "216" "23.7" "9.41" "197.29" "12" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "5479" "ENSG00000166794" "PPIB" "A8K534; hsa:5479; P23284; Q6IBH5; Q9BVK5" "Prolactin signaling pathway; Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes; SARS-CoV-1 activates/modulates innate immune responses" "4" "0" "1.025" "0.973" "1.017" "1.009" "1.057" "0.993" "0.993" "0.984" "0.785" "4818.3" "4940.5" "4686.0" "4899.6" "4860.9" "5095.2" "4786.9" "4784.3" "4741.0" "3780.0" "" "" "" "" "" "" "" "" "" "" "4332.2" "3997.7" "4238.6" "4782.7" "4011.3" "5095.2" "3584.3" "4225.8" "4242.2" "1349.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604354164667528726" "False" "High" "IsMasterProtein" "Q13769" "THO complex subunit 5 homolog OS=Homo sapiens OX=9606 GN=THOC5 PE=1 SV=2" "0.000" "False" "78.037" "29" "17" "29" "17" "683" "78.5" "6.87" "100.54" "17" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09766" "8563" "ENSG00000100296" "THOC5" "hsa:8563; O60839; Q13769; Q9UPZ5" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Signaling by CSF1 (M-CSF) in myeloid cells" "4" "0" "1.117" "1.040" "1.002" "1.152" "1.086" "1.025" "1.045" "1.147" "0.897" "2124.0" "2373.2" "2209.8" "2129.1" "2446.1" "2306.9" "2177.0" "2218.9" "2436.1" "1905.5" "" "" "" "" "" "" "" "" "" "" "1909.7" "1920.3" "1998.8" "2078.3" "2018.5" "2306.9" "1630.1" "1959.9" "2179.8" "680.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-885056090803738498" "False" "High" "IsMasterProtein" "P47897" "Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS1 PE=1 SV=1" "0.000" "False" "77.984" "31" "22" "34" "21" "775" "87.7" "7.15" "105.42" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00749, Pf03950, Pf04557, Pf04558, Pf20974" "5859" "ENSG00000172053" "QARS1" "B4DWJ2; hsa:5859; P47897" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation; Mitochondrial tRNA aminoacylation" "3" "0" "1.024" "1.070" "0.987" "0.989" "1.040" "1.077" "0.898" "1.018" "3.043" "1663.7" "1704.1" "1780.6" "1641.3" "1645.4" "1730.8" "1791.3" "1494.0" "1693.4" "5062.4" "" "" "" "" "" "" "" "" "" "" "1495.9" "1378.9" "1610.7" "1602.1" "1357.8" "1730.8" "1341.3" "1319.6" "1515.2" "1807.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4267649636453152821" "False" "High" "IsMasterProtein" "P16949" "Stathmin OS=Homo sapiens OX=9606 GN=STMN1 PE=1 SV=3" "0.000" "False" "77.817" "67" "16" "80" "15" "149" "17.3" "5.97" "270.42" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00836" "3925" "ENSG00000117632" "STMN1" "A2A2D1; B2R4E7; B7Z8N4; D3DPJ5; hsa:3925; P16949" "Microtubule cytoskeleton regulation; Retinoblastoma gene in cancer; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway" "Nuclear signaling by ERBB4" "7" "0" "1.091" "0.912" "1.003" "0.858" "1.048" "0.912" "1.048" "0.816" "0.746" "7016.8" "7655.9" "6399.3" "7041.2" "6017.1" "7352.3" "6401.9" "7356.2" "5725.6" "5234.8" "" "" "" "" "" "" "" "" "" "" "6308.8" "6194.9" "5788.4" "6873.2" "4965.4" "7352.3" "4793.6" "6497.5" "5123.2" "1868.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3948795116760064813" "False" "High" "IsMasterProtein" "Q7Z2Z2" "Elongation factor-like GTPase 1 OS=Homo sapiens OX=9606 GN=EFL1 PE=1 SV=2" "0.000" "False" "77.777" "23" "23" "30" "23" "1120" "125.4" "5.91" "109.72" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00009, Pf00679, Pf14492" "79631" "ENSG00000140598" "EFL1" "A6NKY5; B7Z6I0; hsa:79631; Q7Z2Z2; Q9H8Z6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.033" "1.077" "0.994" "1.069" "1.046" "1.012" "1.014" "1.064" "1.000" "2228.4" "2302.9" "2399.3" "2214.7" "2382.2" "2331.6" "2254.2" "2260.1" "2370.5" "2228.6" "" "" "" "" "" "" "" "" "" "" "2003.6" "1863.4" "2170.2" "2161.9" "1965.9" "2331.6" "1687.9" "1996.3" "2121.1" "795.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1748573463469303870" "False" "High" "IsMasterProtein" "Q99661" "Kinesin-like protein KIF2C OS=Homo sapiens OX=9606 GN=KIF2C PE=1 SV=2" "0.000" "False" "77.720" "30" "17" "21" "16" "725" "81.3" "7.83" "87.72" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "11004" "ENSG00000142945" "KIF2C" "B3ITR9; hsa:11004; Q5JR88; Q6ICU1; Q96C18; Q96HB8; Q99661; Q9BWV8" "Microtubule cytoskeleton regulation" "Resolution of Sister Chromatid Cohesion; MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Kinesins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.050" "1.156" "0.984" "1.066" "1.188" "1.038" "0.977" "1.176" "1.328" "1259.6" "1323.2" "1456.1" "1239.7" "1342.7" "1496.7" "1307.1" "1230.1" "1481.4" "1672.3" "" "" "" "" "" "" "" "" "" "" "1132.5" "1070.6" "1317.1" "1210.1" "1108.0" "1496.7" "978.7" "1086.5" "1325.6" "596.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "882715983706929749" "False" "High" "IsMasterProtein" "Q9NZ08" "Endoplasmic reticulum aminopeptidase 1 OS=Homo sapiens OX=9606 GN=ERAP1 PE=1 SV=3" "0.000" "False" "77.684" "21" "20" "26" "20" "941" "107.2" "6.46" "95.54" "20" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01433, Pf11838, Pf17900" "51752" "ENSG00000164307" "ERAP1" "hsa:51752; O60278; Q6UWY6; Q8NEL4; Q8TAD0; Q9NZ08; Q9UHF8; Q9UKY2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "0.998" "1.044" "0.973" "1.027" "0.979" "1.017" "0.999" "1.033" "1.025" "1490.8" "1487.1" "1555.8" "1450.7" "1531.2" "1459.4" "1515.8" "1489.9" "1539.7" "1527.9" "" "" "" "" "" "" "" "" "" "" "1340.4" "1203.3" "1407.3" "1416.1" "1263.6" "1459.4" "1135.0" "1316.0" "1377.7" "545.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077624206486076316" "False" "High" "IsMasterProtein" "Q8TC07" "TBC1 domain family member 15 OS=Homo sapiens OX=9606 GN=TBC1D15 PE=1 SV=2" "0.000" "False" "77.501" "29" "19" "21" "19" "691" "79.4" "5.67" "86.30" "19" "other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00566, Pf12068" "64786" "ENSG00000121749" "TBC1D15" "B4DMT9; B9A6L6; hsa:64786; J3KNI9; Q8TC07; Q9HA83" "" "TBC/RABGAPs" "1" "0" "1.046" "0.981" "0.949" "0.971" "0.904" "1.023" "0.968" "0.931" "1.351" "2063.5" "2158.1" "2024.0" "1957.4" "2003.2" "1865.6" "2110.5" "1998.1" "1921.6" "2787.6" "" "" "" "" "" "" "" "" "" "" "1855.3" "1746.3" "1830.8" "1910.7" "1653.1" "1865.6" "1580.3" "1764.9" "1719.5" "995.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184402302268645522" "False" "High" "IsMasterProtein" "Q5JRX3" "Presequence protease, mitochondrial OS=Homo sapiens OX=9606 GN=PITRM1 PE=1 SV=3" "0.000" "False" "77.455" "21" "22" "31" "22" "1037" "117.3" "6.92" "108.59" "22" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "enzyme regulator activity;other molecular function" "Pf00675, Pf05193, Pf08367" "10531" "ENSG00000107959" "PITRM1" "B3KMJ6; B4E0J8; C9JSL2; E7ES23; hsa:10531; O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q5JRX3; Q7L5Z7; Q9BSI6; Q9BVJ5; Q9UPP8" "" "Mitochondrial protein import" "1" "0" "0.977" "1.038" "0.982" "1.023" "1.009" "1.024" "0.979" "0.993" "1.312" "2786.1" "2720.9" "2890.9" "2737.0" "2850.0" "2809.9" "2852.4" "2728.8" "2766.9" "3654.4" "" "" "" "" "" "" "" "" "" "" "2505.0" "2201.6" "2615.0" "2671.7" "2351.9" "2809.9" "2135.8" "2410.3" "2475.8" "1304.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2375108519350628678" "False" "High" "IsMasterProtein" "Q13547" "Histone deacetylase 1 OS=Homo sapiens OX=9606 GN=HDAC1 PE=1 SV=1" "0.000" "False" "77.445" "43" "17" "36" "12" "482" "55.1" "5.48" "124.47" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "3065" "ENSG00000116478" "HDAC1" "hsa:3065; Q13547; Q92534" "Androgen receptor signaling pathway; Energy metabolism; Cell cycle; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Retinoblastoma gene in cancer; Notch signaling; Apoptosis-related network due to altered Notch3 in ovarian cancer; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; IL6 signaling pathway; TGF-beta signaling pathway; Valproic acid pathway; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Rett syndrome; Effect of progerin on genes involved in progeria; Ciliary landscape; Transcription co-factors SKI and SKIL protein partners; Overlap between signal transduction pathways contributing to LMNA laminopathies; Opioid receptor pathways; 15q11q13 copy number variation; Notch signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Potential therapeutics for SARS; Estrogen-dependent gene expression; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; MECP2 regulates transcription of neuronal ligands; Factors involved in megakaryocyte development and platelet production; Downregulation of SMAD2/3:SMAD4 transcriptional activity; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; G1/S-Specific Transcription; Regulation of TP53 Activity through Acetylation; Transcription of E2F targets under negative control by DREAM complex; Nuclear events stimulated by ALK signaling in cancer; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; MECP2 regulates neuronal receptors and channels; Repression of WNT target genes; Loss of MECP2 binding ability to 5mC-DNA" "56" "6" "1.060" "1.033" "1.029" "1.024" "1.055" "1.039" "1.021" "1.046" "1.354" "2893.7" "3066.0" "2988.8" "2979.0" "2963.8" "3053.5" "3005.7" "2953.5" "3025.9" "3918.3" "" "" "" "" "" "" "" "" "" "" "2601.7" "2480.9" "2703.5" "2907.9" "2445.8" "3053.5" "2250.6" "2608.7" "2707.5" "1398.7" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9216601272429108085" "False" "High" "IsMasterProtein" "Q96GX9" "Methylthioribulose-1-phosphate dehydratase OS=Homo sapiens OX=9606 GN=APIP PE=1 SV=1" "0.000" "False" "77.300" "52" "10" "39" "10" "242" "27.1" "7.12" "133.99" "10" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00596" "51074" "ENSG00000149089" "APIP" "A8K9D3; hsa:51074; Q6PJX6; Q8WVU2; Q96GX9; Q96HK2; Q9Y318" "Methionine de novo and salvage pathway" "Regulation of the apoptosome activity; Methionine salvage pathway" "4" "0" "1.003" "1.030" "1.037" "1.048" "0.969" "1.016" "0.987" "1.044" "0.830" "3202.5" "3211.1" "3297.9" "3320.9" "3354.9" "3101.8" "3253.9" "3160.5" "3344.3" "2658.6" "" "" "" "" "" "" "" "" "" "" "2879.4" "2598.3" "2983.0" "3241.6" "2768.6" "3101.8" "2436.4" "2791.5" "2992.5" "949.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2934429115890705699" "False" "High" "IsMasterProtein" "P49821" "NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV1 PE=1 SV=4" "0.000" "False" "77.242" "41" "15" "23" "15" "464" "50.8" "8.21" "96.20" "15" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion" "transporter activity;other molecular function" "Pf01512, Pf10589" "4723" "ENSG00000167792" "NDUFV1" "hsa:4723; O60924; O60940; P49821; Q16104; Q6IBR3; Q96BF8; Q96HS7" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; HDAC6 interactions in the central nervous system; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "1.036" "1.101" "0.993" "1.122" "1.107" "0.980" "1.077" "1.156" "0.705" "1805.3" "1870.5" "1987.2" "1793.0" "2024.8" "1998.3" "1769.7" "1944.5" "2086.9" "1273.1" "" "" "" "" "" "" "" "" "" "" "1623.1" "1513.6" "1797.5" "1750.2" "1670.9" "1998.3" "1325.1" "1717.5" "1867.4" "454.5" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4306142825200876867" "False" "High" "IsMasterProtein" "P11766" "Alcohol dehydrogenase class-3 OS=Homo sapiens OX=9606 GN=ADH5 PE=1 SV=4" "0.000" "False" "77.159" "38" "14" "34" "14" "374" "39.7" "7.49" "118.75" "14" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00107, Pf08240" "128" "ENSG00000197894" "ADH5" "hsa:128; P11766; Q6FHR2" "Folate-alcohol and cancer pathway hypotheses; Amino acid metabolism" "Ethanol oxidation" "3" "0" "1.000" "1.026" "0.988" "1.003" "0.975" "1.015" "0.971" "1.027" "0.742" "4342.9" "4344.4" "4457.7" "4291.7" "4353.9" "4234.2" "4409.1" "4216.2" "4459.9" "3220.6" "" "" "" "" "" "" "" "" "" "" "3904.6" "3515.3" "4032.2" "4189.3" "3592.9" "4234.2" "3301.4" "3724.0" "3990.7" "1149.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7680692845404357414" "False" "High" "IsMasterProtein" "P30085" "UMP-CMP kinase OS=Homo sapiens OX=9606 GN=CMPK1 PE=1 SV=3" "0.000" "False" "77.134" "45" "9" "31" "9" "196" "22.2" "5.57" "125.72" "9" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00406" "51727" "ENSG00000162368" "CMPK1" "B2R6S5; B4DPU7; E9PGI8; hsa:51727; P30085; Q53GB7; Q5SVZ0; Q96C07; Q9UBQ8; Q9UIA2" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.025" "1.061" "1.016" "1.055" "1.120" "0.982" "1.100" "1.026" "0.897" "2561.0" "2625.2" "2717.5" "2602.8" "2701.0" "2867.7" "2514.7" "2817.7" "2626.9" "2297.9" "" "" "" "" "" "" "" "" "" "" "2302.6" "2124.3" "2458.1" "2540.7" "2228.9" "2867.7" "1882.9" "2488.8" "2350.5" "820.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9124965961007810906" "False" "High" "IsMasterProtein" "P11387" "DNA topoisomerase 1 OS=Homo sapiens OX=9606 GN=TOP1 PE=1 SV=2" "0.000" "False" "77.085" "28" "22" "30" "22" "765" "90.7" "9.31" "95.23" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf01028, Pf02919, Pf14370" "7150" "ENSG00000198900" "TOP1" "A8KA78; E1P5W3; hsa:7150; O43256; P11387; Q12855; Q12856; Q15610; Q5TFY3; Q9UJN0" "Ebola virus infection in host; 15q25 copy number variation" "SUMOylation of DNA replication proteins" "3" "0" "0.921" "0.944" "0.857" "0.915" "1.064" "0.945" "0.812" "0.765" "2.082" "2313.1" "2131.0" "2182.5" "1981.5" "2117.3" "2460.2" "2186.5" "1877.2" "1769.2" "4815.1" "" "" "" "" "" "" "" "" "" "" "2079.7" "1724.3" "1974.1" "1934.3" "1747.2" "2460.2" "1637.2" "1658.0" "1583.0" "1718.9" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8452919191869770403" "False" "High" "IsMasterProtein" "Q8WVV9" "Heterogeneous nuclear ribonucleoprotein L-like OS=Homo sapiens OX=9606 GN=HNRNPLL PE=1 SV=1" "0.000" "False" "77.043" "33" "16" "23" "15" "542" "60.0" "7.72" "95.17" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "92906" "ENSG00000143889" "HNRNPLL" "hsa:92906; Q53T80; Q5JB51; Q5JB52; Q659B9; Q8IVH5; Q8IVH6; Q8WVV9; Q96HR5" "" "" "0" "1" "1.002" "0.961" "0.984" "1.010" "0.976" "1.032" "0.992" "1.001" "1.558" "2131.6" "2136.4" "2047.9" "2097.2" "2152.8" "2080.6" "2199.7" "2113.6" "2134.0" "3320.7" "" "" "" "" "" "" "" "" "" "" "1916.5" "1728.7" "1852.4" "2047.1" "1776.6" "2080.6" "1647.1" "1866.8" "1909.5" "1185.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8717421015690566095" "False" "High" "IsMasterProtein" "Q9NQR4" "Omega-amidase NIT2 OS=Homo sapiens OX=9606 GN=NIT2 PE=1 SV=1" "0.000" "False" "76.925" "62" "15" "30" "15" "276" "30.6" "7.21" "109.25" "15" "other metabolic processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00795" "56954" "ENSG00000114021" "NIT2" "B2R9A3; D3DN47; hsa:56954; Q8WUF0; Q9NQR4" "" "Neutrophil degranulation" "1" "0" "0.965" "0.984" "1.020" "0.971" "0.947" "0.960" "0.980" "0.980" "0.812" "2507.3" "2419.4" "2466.2" "2557.7" "2434.7" "2374.0" "2406.2" "2456.0" "2457.1" "2035.1" "" "" "" "" "" "" "" "" "" "" "2254.3" "1957.7" "2230.8" "2496.6" "2009.2" "2374.0" "1801.7" "2169.3" "2198.6" "726.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4764020307768204184" "False" "High" "IsMasterProtein" "P61586" "Transforming protein RhoA OS=Homo sapiens OX=9606 GN=RHOA PE=1 SV=1" "0.000" "False" "76.919" "60" "11" "54" "11" "193" "21.8" "6.10" "181.22" "11" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "387" "ENSG00000067560" "RHOA" "hsa:387; P06749; P61586; Q53HM4; Q5U024; Q9UDJ0; Q9UEJ4" "Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Leptin signaling pathway; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Fibrin complement receptor 3 signaling pathway; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Joubert syndrome; Gastrin signaling pathway; Netrin-UNC5B signaling pathway; mBDNF and proBDNF regulation of GABA neurotransmission; MAP3K1 role in promoting and blocking gonadal determination; Airway smooth muscle cell contraction; RAS and bradykinin pathways in COVID-19; Regulation of actin cytoskeleton; GDNF signaling; PtdIns(4,5)P2 in cytokinesis pathway; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; G13 signaling pathway; 13q12.12 copy number variation; GNAQ pathways in port-wine stain; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "Neutrophil degranulation; RHOC GTPase cycle; RHOA GTPase cycle; G alpha (12/13) signalling events; RHO GTPases Activate Formins; EPHB-mediated forward signaling; GPVI-mediated activation cascade; PI3K/AKT activation; VEGFA-VEGFR2 Pathway; ERBB2 Regulates Cell Motility; RHO GTPases activate CIT; G beta:gamma signalling through PI3Kgamma; PCP/CE pathway; RHO GTPases Activate Rhotekin and Rhophilins; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; Sema4D mediated inhibition of cell attachment and migration; Ovarian tumor domain proteases; SLIT2:ROBO1 increases RHOA activity; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); Axonal growth stimulation; Axonal growth inhibition (RHOA activation); RHO GTPases activate KTN1" "71" "0" "0.955" "0.937" "1.105" "0.876" "1.042" "0.928" "1.001" "0.914" "0.761" "6539.8" "6244.3" "6127.8" "7229.4" "5730.1" "6812.3" "6071.0" "6547.6" "5980.1" "4977.1" "" "" "" "" "" "" "" "" "" "" "5879.9" "5052.7" "5542.8" "7056.9" "4728.6" "6812.3" "4545.8" "5783.3" "5351.0" "1776.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "380147253527428052" "False" "High" "IsMasterProtein" "Q9NRR5" "Ubiquilin-4 OS=Homo sapiens OX=9606 GN=UBQLN4 PE=1 SV=2" "0.000" "False" "76.853" "29" "13" "38" "10" "601" "63.8" "5.22" "129.60" "13" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf00627" "56893" "ENSG00000160803" "UBQLN4" "A6ND44; B2RAY7; hsa:56893; Q5VYA0; Q5VYA1; Q9BR98; Q9NRR5; Q9UHX4" "" "" "0" "4" "1.026" "1.005" "0.967" "1.058" "1.056" "1.012" "1.014" "1.017" "0.908" "1939.3" "1988.9" "1948.9" "1875.6" "2052.3" "2047.2" "1962.9" "1967.3" "1973.2" "1761.4" "" "" "" "" "" "" "" "" "" "" "1743.6" "1609.3" "1762.8" "1830.8" "1693.6" "2047.2" "1469.8" "1737.7" "1765.6" "628.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3039044237151127382" "False" "High" "IsMasterProtein" "P61163" "Alpha-centractin OS=Homo sapiens OX=9606 GN=ACTR1A PE=1 SV=1" "0.000" "False" "76.712" "35" "12" "31" "7" "376" "42.6" "6.64" "114.58" "12" "transport" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10121" "ENSG00000138107" "ACTR1A" "B2R6B0; hsa:10121; P42024; P61163" "HDAC6 interactions in the central nervous system" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "12" "5" "1.001" "1.028" "0.977" "1.002" "0.995" "0.973" "0.990" "1.005" "0.842" "2540.3" "2541.9" "2611.3" "2482.3" "2544.8" "2526.7" "2470.9" "2515.1" "2552.2" "2139.5" "" "" "" "" "" "" "" "" "" "" "2284.0" "2056.9" "2362.0" "2423.1" "2100.0" "2526.7" "1850.2" "2221.5" "2283.7" "763.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6734575471453550747" "False" "High" "IsMasterProtein" "Q6FI81" "Anamorsin OS=Homo sapiens OX=9606 GN=CIAPIN1 PE=1 SV=2" "0.000" "False" "76.661" "62" "19" "29" "19" "312" "33.6" "5.62" "101.32" "19" "cell organization and biogenesis;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05093, Pf20922" "57019" "ENSG00000005194" "CIAPIN1" "A8K8B6; hsa:57019; O75206; O75207; Q6FI81; Q9H0W1; Q9P1L7" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.020" "1.101" "1.057" "1.065" "1.046" "1.036" "1.091" "1.031" "0.878" "2698.5" "2752.3" "2971.9" "2852.5" "2874.3" "2823.1" "2796.6" "2944.5" "2781.4" "2369.5" "" "" "" "" "" "" "" "" "" "" "2426.2" "2227.0" "2688.2" "2784.4" "2371.9" "2823.1" "2094.0" "2600.8" "2488.8" "845.8" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2868911152044451366" "False" "High" "IsMasterProtein" "Q99570" "Phosphoinositide 3-kinase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PIK3R4 PE=1 SV=3" "0.000" "False" "76.612" "18" "23" "29" "23" "1358" "153.0" "7.17" "89.29" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00400" "30849" "ENSG00000196455" "PIK3R4" "hsa:30849; Q2TBF4; Q99570" "Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Ciliopathies; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; PI3K Cascade; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "25" "0" "1.062" "1.082" "0.985" "1.053" "1.025" "1.042" "1.014" "1.033" "1.024" "1984.5" "2106.6" "2148.1" "1953.9" "2090.2" "2033.6" "2067.5" "2012.3" "2050.7" "2031.5" "" "" "" "" "" "" "" "" "" "" "1784.2" "1704.6" "1943.0" "1907.3" "1724.9" "2033.6" "1548.1" "1777.4" "1834.9" "725.2" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5233128446451314475" "False" "High" "IsMasterProtein" "Q8IVD9" "NudC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NUDCD3 PE=1 SV=3" "0.000" "False" "76.598" "53" "17" "31" "17" "361" "40.8" "5.25" "133.73" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf04969, Pf14050" "23386" "ENSG00000015676" "NUDCD3" "hsa:23386; Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4" "" "" "0" "0" "1.062" "0.955" "1.001" "1.057" "0.952" "1.034" "1.037" "0.982" "1.103" "1868.6" "1984.3" "1785.3" "1869.9" "1975.7" "1778.3" "1932.4" "1937.1" "1834.5" "2060.6" "" "" "" "" "" "" "" "" "" "" "1680.0" "1605.6" "1614.9" "1825.3" "1630.4" "1778.3" "1446.9" "1710.9" "1641.5" "735.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9189590484777075943" "False" "High" "IsMasterProtein" "Q13185" "Chromobox protein homolog 3 OS=Homo sapiens OX=9606 GN=CBX3 PE=1 SV=4" "0.000" "False" "76.593" "45" "8" "46" "6" "183" "20.8" "5.33" "188.40" "8" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "11335" "ENSG00000122565" "CBX3" "hsa:11335; Q13185; Q96CD7; Q99409; Q9BVS3; Q9P0Z6" "Exercise-induced circadian regulation; Effect of progerin on genes involved in progeria; NIPBL role in DNA damage - Cornelia de Lange syndrome" "RNA Polymerase I Promoter Escape; Transcriptional Regulation by E2F6; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "6" "4" "0.944" "0.891" "0.947" "0.958" "0.902" "0.989" "1.024" "0.877" "0.906" "5798.2" "5472.0" "5165.8" "5492.0" "5555.5" "5231.2" "5737.0" "5935.1" "5085.0" "5252.1" "" "" "" "" "" "" "" "" "" "" "5213.2" "4427.8" "4672.6" "5360.9" "4584.5" "5231.2" "4295.7" "5242.3" "4550.1" "1874.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9193624318579361527" "False" "High" "IsMasterProtein" "Q9UGI8" "Testin OS=Homo sapiens OX=9606 GN=TES PE=1 SV=1" "0.000" "False" "76.589" "46" "18" "27" "18" "421" "48.0" "7.68" "94.91" "18" "other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412, Pf06297" "26136" "ENSG00000135269" "TES" "A4D0U6; hsa:26136; Q9GZQ1; Q9HAJ9; Q9UGI8" "" "" "0" "0" "0.966" "0.964" "0.918" "0.987" "1.023" "0.948" "1.019" "0.979" "0.778" "2019.4" "1950.5" "1946.5" "1853.4" "1992.2" "2065.1" "1913.8" "2058.5" "1976.8" "1570.3" "" "" "" "" "" "" "" "" "" "" "1815.7" "1578.3" "1760.7" "1809.2" "1644.0" "2065.1" "1433.0" "1818.2" "1768.8" "560.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "687508345564059484" "False" "High" "IsMasterProtein" "Q15436" "Protein transport protein Sec23A OS=Homo sapiens OX=9606 GN=SEC23A PE=1 SV=2" "0.000" "False" "76.561" "27" "18" "33" "15" "765" "86.1" "7.08" "118.07" "18" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10484" "ENSG00000100934" "SEC23A" "B2R5P4; B3KXI2; hsa:10484; Q15436; Q8NE16" "Sterol regulatory element-binding proteins (SREBP) signaling" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC; MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF)" "7" "3" "1.054" "0.986" "1.000" "1.002" "1.167" "1.041" "0.983" "1.015" "0.895" "1692.9" "1783.6" "1670.0" "1692.4" "1696.9" "1975.1" "1762.0" "1663.8" "1717.8" "1514.8" "" "" "" "" "" "" "" "" "" "" "1522.1" "1443.2" "1510.5" "1652.0" "1400.3" "1975.1" "1319.3" "1469.6" "1537.1" "540.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594801350968766228" "False" "High" "IsMasterProtein" "Q99986" "Serine/threonine-protein kinase VRK1 OS=Homo sapiens OX=9606 GN=VRK1 PE=1 SV=1" "0.000" "False" "76.455" "36" "13" "26" "13" "396" "45.4" "8.91" "102.13" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "kinase activity;other molecular function" "Pf00069" "7443" "ENSG00000100749" "VRK1" "hsa:7443; Q3SYL2; Q99986" "" "Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "2" "0" "0.899" "0.918" "0.949" "0.873" "0.887" "0.917" "0.897" "0.871" "1.405" "2979.6" "2679.5" "2734.6" "2826.4" "2600.5" "2642.0" "2732.1" "2673.6" "2595.6" "4185.6" "" "" "" "" "" "" "" "" "" "" "2678.9" "2168.2" "2473.6" "2759.0" "2146.0" "2642.0" "2045.7" "2361.5" "2322.5" "1494.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7169835918379755143" "False" "High" "IsMasterProtein" "P39687" "Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Homo sapiens OX=9606 GN=ANP32A PE=1 SV=1" "0.000" "False" "76.302" "41" "14" "75" "9" "249" "28.6" "4.09" "247.27" "14" "transport;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf14580" "8125" "ENSG00000140350" "ANP32A" "B2R6T4; hsa:8125; P39687; Q53FK4; Q5J8L8; Q7M4N6" "IL-18 signaling pathway" "HuR (ELAVL1) binds and stabilizes mRNA" "2" "4" "0.935" "0.941" "1.023" "0.948" "0.956" "0.978" "1.026" "0.917" "0.813" "6127.7" "5728.0" "5766.9" "6270.1" "5806.1" "5855.7" "5995.2" "6287.2" "5621.6" "4983.2" "" "" "" "" "" "" "" "" "" "" "5509.4" "4634.9" "5216.3" "6120.5" "4791.3" "5855.7" "4489.1" "5553.3" "5030.2" "1778.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1839612719642205858" "False" "High" "IsMasterProtein" "P09417" "Dihydropteridine reductase OS=Homo sapiens OX=9606 GN=QDPR PE=1 SV=2" "0.000" "False" "76.208" "57" "10" "28" "10" "244" "25.8" "7.37" "121.77" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00106" "5860" "ENSG00000151552" "QDPR" "A8K158; B3KW71; hsa:5860; P09417; Q53F52; Q9H3M5" "" "Phenylalanine metabolism" "1" "0" "0.963" "0.988" "0.950" "1.001" "0.947" "0.962" "0.941" "1.027" "0.802" "2892.8" "2784.9" "2859.1" "2748.3" "2895.7" "2738.2" "2781.5" "2722.5" "2971.0" "2320.1" "" "" "" "" "" "" "" "" "" "" "2600.9" "2253.5" "2586.1" "2682.8" "2389.6" "2738.2" "2082.7" "2404.7" "2658.4" "828.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "467994795181612484" "False" "High" "IsMasterProtein" "Q92793" "CREB-binding protein OS=Homo sapiens OX=9606 GN=CREBBP PE=1 SV=3" "0.000" "False" "76.203" "10" "23" "32" "13" "2442" "265.2" "8.53" "99.65" "23" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00569, Pf02135, Pf02172, Pf06001, Pf08214, Pf09030" "1387" "ENSG00000005339" "CREBBP" "D3DUC9; O00147; Q16376; Q4LE28; Q92793" "Androgen receptor signaling pathway; Angiogenesis; TNF-alpha signaling pathway; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; Clear cell renal cell carcinoma pathways; Ebola virus infection in host; Type 2 papillary renal cell carcinoma; Ciliary landscape; Hepatitis B infection; Male infertility; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; 15q13.3 copy number variation syndrome; Urotensin-II-mediated signaling pathway; Rubinstein-Taybi syndrome 1; 15q11q13 copy number variation; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Heme signaling; NFE2L2 regulating anti-oxidant/detoxification enzymes; SUMOylation of transcription cofactors; Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Zygotic genome activation (ZGA); PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; NPAS4 regulates expression of target genes; Formation of the beta-catenin:TCF transactivating complex; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); HATs acetylate histones; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating tumorigenic genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; RORA activates gene expression; Attenuation phase; CD209 (DC-SIGN) signaling; Activation of the TFAP2 (AP-2) family of transcription factors; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of gene expression by Hypoxia-inducible Factor; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production" "74" "0" "1.039" "1.000" "1.080" "1.040" "0.934" "1.054" "1.033" "1.017" "1.022" "1406.3" "1461.6" "1406.3" "1518.8" "1462.2" "1314.0" "1482.2" "1453.3" "1429.6" "1436.9" "" "" "" "" "" "" "" "" "" "" "1264.4" "1182.7" "1272.0" "1482.6" "1206.6" "1314.0" "1109.8" "1283.6" "1279.2" "512.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4770714879888361237" "False" "High" "IsMasterProtein" "Q5GLZ8" "Probable E3 ubiquitin-protein ligase HERC4 OS=Homo sapiens OX=9606 GN=HERC4 PE=1 SV=1" "0.000" "False" "76.121" "24" "22" "30" "22" "1057" "118.5" "6.19" "97.44" "22" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632" "26091" "ENSG00000148634" "HERC4" "hsa:26091; Q5GC98; Q5GC99; Q5GCA0; Q5GLZ8; Q8IXP9; Q9HCH9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.011" "0.989" "0.938" "1.062" "0.944" "1.056" "0.963" "1.009" "0.993" "1803.0" "1822.0" "1783.8" "1691.0" "1915.3" "1701.5" "1903.6" "1735.6" "1819.1" "1791.1" "" "" "" "" "" "" "" "" "" "" "1621.1" "1474.3" "1613.5" "1650.6" "1580.5" "1701.5" "1425.3" "1533.0" "1627.8" "639.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5513100547130879649" "False" "High" "IsMasterProtein" "P13797" "Plastin-3 OS=Homo sapiens OX=9606 GN=PLS3 PE=1 SV=4" "0.000" "False" "76.100" "13" "9" "128" "1" "630" "70.8" "5.60" "417.76" "9" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf13499" "5358" "ENSG00000102024" "PLS3" "A8K579; B1AQ09; B4DGB4; B7Z6M1; hsa:5358; P13797; Q86YI6" "" "" "0" "0" "1.011" "1.059" "0.941" "1.087" "1.002" "0.981" "1.029" "1.060" "0.713" "488.3" "493.6" "517.0" "459.7" "530.9" "489.1" "479.3" "502.6" "517.4" "348.4" "" "" "" "" "" "" "" "" "" "" "439.1" "399.4" "467.6" "448.7" "438.1" "489.1" "358.9" "443.9" "463.0" "124.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059296943260836861" "False" "High" "IsMasterProtein" "Q15286" "Ras-related protein Rab-35 OS=Homo sapiens OX=9606 GN=RAB35 PE=1 SV=1" "0.000" "False" "75.996" "76" "12" "41" "9" "201" "23.0" "8.29" "144.54" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "11021" "ENSG00000111737" "RAB35" "B2R6E0; B4E390; hsa:11021; Q15286" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "3" "1" "0.894" "0.977" "0.961" "0.968" "0.899" "0.939" "0.901" "0.989" "0.765" "2523.4" "2256.2" "2465.3" "2424.6" "2442.2" "2268.9" "2369.4" "2272.9" "2495.2" "1929.3" "" "" "" "" "" "" "" "" "" "" "2268.8" "1825.6" "2230.0" "2366.8" "2015.4" "2268.9" "1774.2" "2007.6" "2232.7" "688.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1749791296604860145" "False" "High" "IsMasterProtein" "Q9BTE6" "Alanyl-tRNA editing protein Aarsd1 OS=Homo sapiens OX=9606 GN=AARSD1 PE=1 SV=2" "0.000" "False" "75.988" "49" "14" "25" "14" "412" "45.5" "6.42" "113.40" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07973" "100885850; 80755" "ENSG00000108825; ENSG00000266967" "AARSD1" "B4DI73; hsa:100885850; hsa:80755; Q9BTE6" "" "" "0" "0" "1.053" "1.027" "0.970" "1.079" "1.064" "1.039" "1.050" "1.058" "0.904" "1566.3" "1648.6" "1608.1" "1519.3" "1690.5" "1666.2" "1627.2" "1645.0" "1657.8" "1415.5" "" "" "" "" "" "" "" "" "" "" "1408.2" "1334.0" "1454.6" "1483.0" "1395.0" "1666.2" "1218.4" "1452.9" "1483.4" "505.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6639457363078970209" "False" "High" "IsMasterProtein" "P35659" "Protein DEK OS=Homo sapiens OX=9606 GN=DEK PE=1 SV=1" "0.000" "False" "75.860" "38" "13" "29" "13" "375" "42.6" "8.56" "111.03" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf08766" "7913" "ENSG00000124795" "DEK" "B2R6K6; B4DN37; hsa:7913; P35659; Q5TGV4; Q5TGV5" "IL-18 signaling pathway; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; Transcriptional regulation of granulopoiesis; Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors" "5" "0" "0.858" "0.886" "0.914" "0.908" "1.016" "0.890" "0.844" "0.822" "0.981" "3410.5" "2926.6" "3021.2" "3115.8" "3096.0" "3464.5" "3035.4" "2879.8" "2803.7" "3345.4" "" "" "" "" "" "" "" "" "" "" "3066.4" "2368.1" "2732.7" "3041.5" "2554.9" "3464.5" "2272.9" "2543.7" "2508.7" "1194.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2580326738670543746" "False" "High" "IsMasterProtein" "O60341" "Lysine-specific histone demethylase 1A OS=Homo sapiens OX=9606 GN=KDM1A PE=1 SV=2" "0.000" "False" "75.852" "25" "20" "25" "20" "852" "92.8" "6.52" "85.95" "20" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01593, Pf04433" "23028" "ENSG00000004487" "KDM1A" "A8MWP9; hsa:23028; O60341; Q5TH94; Q5TH95; Q86VT7; Q8IXK4; Q8NDP6; Q8TAZ3; Q96AW4" "Androgen receptor signaling pathway; Effect of progerin on genes involved in progeria; Thermogenesis; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Neurogenesis regulation in the olfactory epithelium" "Estrogen-dependent gene expression; Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "14" "0" "0.910" "0.852" "0.941" "0.864" "0.771" "0.947" "0.771" "0.771" "1.573" "1858.4" "1692.0" "1582.7" "1748.2" "1606.0" "1432.4" "1759.2" "1432.1" "1432.3" "2923.9" "" "" "" "" "" "" "" "" "" "" "1670.9" "1369.1" "1431.6" "1706.5" "1325.3" "1432.4" "1317.2" "1264.9" "1281.6" "1043.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3931502688338012469" "False" "High" "IsMasterProtein" "P35249" "Replication factor C subunit 4 OS=Homo sapiens OX=9606 GN=RFC4 PE=1 SV=2" "0.000" "False" "75.794" "55" "16" "23" "16" "363" "39.7" "8.02" "93.63" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5984" "ENSG00000163918" "RFC4" "B4DM41; D3DNV2; hsa:5984; P35249; Q6FHX7" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.035" "1.095" "0.996" "0.990" "1.198" "0.998" "1.044" "1.263" "0.922" "1490.3" "1541.8" "1631.7" "1485.0" "1474.8" "1785.3" "1487.4" "1556.5" "1882.0" "1374.1" "" "" "" "" "" "" "" "" "" "" "1339.9" "1247.6" "1475.9" "1449.6" "1217.0" "1785.3" "1113.7" "1374.8" "1684.0" "490.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "961314597478386434" "False" "High" "IsMasterProtein" "P57740" "Nuclear pore complex protein Nup107 OS=Homo sapiens OX=9606 GN=NUP107 PE=1 SV=1" "0.000" "False" "75.699" "26" "23" "28" "23" "925" "106.3" "5.43" "102.96" "23" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04121" "57122" "ENSG00000111581" "NUP107" "B4DZ67; hsa:57122; P57740; Q6PJE1" "Gastric cancer network 1; Primary ovarian insufficiency" "Separation of Sister Chromatids; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "37" "0" "1.031" "1.013" "0.958" "0.994" "1.046" "1.025" "1.002" "1.000" "1.136" "2142.4" "2209.5" "2170.5" "2053.3" "2128.8" "2240.8" "2196.1" "2147.7" "2142.7" "2434.8" "" "" "" "" "" "" "" "" "" "" "1926.2" "1787.8" "1963.3" "2004.3" "1756.7" "2240.8" "1644.4" "1897.0" "1917.3" "869.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386790215885090291" "False" "High" "IsMasterProtein" "Q8N3X1" "Formin-binding protein 4 OS=Homo sapiens OX=9606 GN=FNBP4 PE=1 SV=3" "0.000" "False" "75.648" "21" "17" "25" "17" "1017" "110.2" "4.74" "95.65" "17" "" "nucleus" "" "Pf00397" "23360" "ENSG00000109920; ENSG00000285182" "FNBP4" "hsa:23360; Q8N3X1; Q9H985; Q9NT81; Q9Y2L7" "" "" "0" "0" "0.983" "0.935" "1.010" "1.042" "0.913" "1.035" "1.043" "0.952" "0.582" "2144.4" "2107.9" "2005.0" "2164.8" "2234.9" "1957.7" "2218.6" "2237.0" "2041.3" "1247.5" "" "" "" "" "" "" "" "" "" "" "1928.0" "1705.6" "1813.6" "2113.2" "1844.3" "1957.7" "1661.3" "1975.9" "1826.5" "445.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629072451512354259" "False" "High" "IsMasterProtein" "P52701" "DNA mismatch repair protein Msh6 OS=Homo sapiens OX=9606 GN=MSH6 PE=1 SV=2" "0.000" "False" "75.644" "17" "20" "23" "20" "1360" "152.7" "6.90" "94.56" "20" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00488, Pf00855, Pf01624, Pf05188, Pf05190, Pf05192" "2956" "ENSG00000116062" "MSH6" "B4DF41; B4E3I4; F5H2F9; hsa:2956; O43706; O43917; P52701; Q8TCX4; Q9BTB5" "Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network; DNA mismatch repair" "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Defective Mismatch Repair Associated With MSH2; Defective Mismatch Repair Associated With MSH6" "8" "0" "0.897" "0.806" "0.972" "0.843" "0.745" "1.045" "0.718" "0.710" "4.807" "2264.7" "2031.9" "1826.1" "2200.3" "1909.3" "1687.8" "2366.0" "1626.0" "1607.6" "10886.2" "" "" "" "" "" "" "" "" "" "" "2036.2" "1644.1" "1651.7" "2147.8" "1575.6" "1687.8" "1771.6" "1436.2" "1438.5" "3886.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1392727006884078861" "False" "High" "IsMasterProtein" "P51692" "Signal transducer and activator of transcription 5B OS=Homo sapiens OX=9606 GN=STAT5B PE=1 SV=2" "0.000" "False" "75.562" "26" "19" "26" "19" "787" "89.8" "6.05" "97.57" "19" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6777" "ENSG00000173757" "STAT5B" "hsa:6777; P51692; Q8WWS8" "IL-5 signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; AGE/RAGE pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; White fat cell differentiation; Non-small cell lung cancer; EGF/EGFR signaling pathway; Measles virus infection; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; IL-2 signaling pathway; 3q29 copy number variation syndrome; FOXP3 in COVID-19; Familial partial lipodystrophy; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; EPO receptor signaling; ErbB signaling pathway" "Interleukin-3, Interleukin-5 and GM-CSF signaling; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Growth hormone receptor signaling; Signaling by Leptin; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Prolactin receptor signaling; Interleukin-20 family signaling; Erythropoietin activates STAT5; Signaling by FLT3 fusion proteins; Interleukin-2 signaling; STAT5 activation downstream of FLT3 ITD mutants; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling; STAT5 Activation" "51" "0" "1.075" "1.052" "0.970" "1.059" "1.005" "1.054" "0.979" "1.086" "1.891" "2037.3" "2190.7" "2143.4" "1976.4" "2158.2" "2046.9" "2147.6" "1995.3" "2211.9" "3853.5" "" "" "" "" "" "" "" "" "" "" "1831.8" "1772.6" "1938.8" "1929.3" "1781.0" "2046.9" "1608.1" "1762.4" "1979.2" "1375.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144815558027084880" "False" "High" "IsMasterProtein" "Q96FV9" "THO complex subunit 1 OS=Homo sapiens OX=9606 GN=THOC1 PE=1 SV=1" "0.000" "False" "75.466" "34" "20" "24" "20" "657" "75.6" "4.98" "86.04" "20" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00531, Pf11957" "9984" "ENSG00000079134" "THOC1" "B2RBP6; hsa:9984; Q15219; Q64I72; Q64I73; Q96FV9" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.963" "0.948" "0.936" "0.959" "0.920" "0.960" "0.898" "0.896" "1.262" "1708.5" "1645.6" "1619.9" "1598.4" "1637.9" "1571.7" "1639.4" "1533.6" "1531.5" "2157.0" "" "" "" "" "" "" "" "" "" "" "1536.1" "1331.5" "1465.2" "1560.2" "1351.6" "1571.7" "1227.5" "1354.6" "1370.3" "770.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1683899515612259900" "False" "High" "IsMasterProtein" "O94776" "Metastasis-associated protein MTA2 OS=Homo sapiens OX=9606 GN=MTA2 PE=1 SV=1" "0.000" "False" "75.444" "32" "21" "35" "17" "668" "75.0" "9.66" "114.50" "21" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9219" "ENSG00000149480" "MTA2" "hsa:9219; O94776; Q68DB1; Q9UQB5" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "3" "0.973" "0.967" "0.958" "0.999" "0.969" "0.995" "0.897" "0.952" "1.322" "2052.9" "1998.3" "1984.3" "1966.9" "2051.5" "1990.2" "2042.7" "1841.6" "1954.7" "2714.0" "" "" "" "" "" "" "" "" "" "" "1845.8" "1617.0" "1794.9" "1919.9" "1693.0" "1990.2" "1529.5" "1626.6" "1749.1" "968.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1328397515797573102" "False" "High" "IsMasterProtein" "A6NDG6" "Glycerol-3-phosphate phosphatase OS=Homo sapiens OX=9606 GN=PGP PE=1 SV=1" "0.000" "False" "75.403" "49" "13" "28" "13" "321" "34.0" "6.14" "109.29" "13" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13242, Pf13344" "283871" "ENSG00000184207" "PGP" "A6NDG6; hsa:283871" "" "Glycolysis" "1" "0" "1.070" "1.070" "1.011" "1.065" "1.032" "1.083" "1.075" "1.093" "0.935" "1768.0" "1892.0" "1891.7" "1786.6" "1882.4" "1825.3" "1913.9" "1900.5" "1933.3" "1653.6" "" "" "" "" "" "" "" "" "" "" "1589.6" "1530.9" "1711.1" "1743.9" "1553.4" "1825.3" "1433.1" "1678.6" "1729.9" "590.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4145241579063427930" "False" "High" "IsMasterProtein" "P68400" "Casein kinase II subunit alpha OS=Homo sapiens OX=9606 GN=CSNK2A1 PE=1 SV=1" "0.000" "False" "75.382" "47" "14" "24" "13" "391" "45.1" "7.74" "103.53" "14" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1457" "ENSG00000101266" "CSNK2A1" "B4DYS6; D3DVV8; hsa:1457; P19138; P20426; P68400; Q14013; Q5U065" "Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Pleural mesothelioma; Alzheimer's disease" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "22" "1" "0.996" "0.986" "0.947" "0.996" "1.068" "0.936" "0.934" "1.020" "1.245" "2352.4" "2343.8" "2319.0" "2227.3" "2343.5" "2511.7" "2203.0" "2197.6" "2400.4" "2927.9" "" "" "" "" "" "" "" "" "" "" "2115.1" "1896.5" "2097.6" "2174.1" "1933.9" "2511.7" "1649.5" "1941.1" "2147.8" "1045.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3092682979585279254" "False" "High" "IsMasterProtein" "Q96BP3" "Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PPWD1 PE=1 SV=1" "0.000" "False" "75.347" "39" "22" "24" "22" "646" "73.5" "7.15" "86.07" "22" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160, Pf00400" "23398" "ENSG00000113593" "PPWD1" "B4DWR9; hsa:23398; Q15002; Q7KZ89; Q96BP3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.065" "1.061" "1.022" "1.081" "1.028" "1.006" "1.001" "1.039" "0.981" "1959.0" "2085.7" "2078.0" "2002.4" "2116.9" "2013.4" "1971.2" "1960.3" "2035.5" "1922.4" "" "" "" "" "" "" "" "" "" "" "1761.4" "1687.7" "1879.6" "1954.6" "1746.9" "2013.4" "1476.0" "1731.5" "1821.3" "686.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9010932242184779008" "False" "High" "IsMasterProtein" "P10644" "cAMP-dependent protein kinase type I-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1A PE=1 SV=1" "0.000" "False" "75.251" "40" "15" "32" "13" "381" "43.0" "5.35" "121.78" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5573" "ENSG00000108946" "PRKAR1A" "hsa:5573; K7ER48; P10644; Q567S7" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants; Hedgehog 'off' state; FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "27" "3" "1.015" "0.956" "1.035" "0.971" "1.032" "0.997" "0.986" "0.963" "1.024" "4170.3" "4232.2" "3986.8" "4318.0" "4051.4" "4302.5" "4158.9" "4113.0" "4014.0" "4268.7" "" "" "" "" "" "" "" "" "" "" "3749.5" "3424.6" "3606.1" "4215.0" "3343.3" "4302.5" "3114.1" "3632.8" "3591.7" "1523.8" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-92542688516821267" "False" "High" "IsMasterProtein" "Q14699" "Raftlin OS=Homo sapiens OX=9606 GN=RFTN1 PE=1 SV=4" "0.000" "False" "75.215" "30" "14" "31" "14" "578" "63.1" "5.67" "121.26" "14" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf15250" "23180" "ENSG00000131378" "RFTN1" "hsa:23180; Q0D2G0; Q14699; Q496Y2; Q4QQI7; Q5JB48; Q7Z7P2" "" "" "0" "0" "1.022" "0.852" "1.011" "0.936" "0.833" "0.988" "0.988" "0.973" "0.574" "2106.9" "2152.5" "1795.9" "2130.3" "1972.3" "1756.0" "2081.3" "2082.5" "2049.1" "1209.2" "" "" "" "" "" "" "" "" "" "" "1894.3" "1741.7" "1624.5" "2079.5" "1627.5" "1756.0" "1558.4" "1839.4" "1833.6" "431.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1535429357355427418" "False" "High" "IsMasterProtein" "Q9UL25" "Ras-related protein Rab-21 OS=Homo sapiens OX=9606 GN=RAB21 PE=1 SV=3" "0.000" "False" "75.200" "52" "10" "27" "10" "225" "24.3" "7.94" "106.83" "10" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "23011" "ENSG00000080371" "RAB21" "hsa:23011; Q14466; Q569H3; Q9UL25" "Ciliary landscape" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "3" "0" "1.036" "0.978" "1.038" "1.025" "1.098" "1.013" "1.014" "1.057" "0.652" "2296.1" "2379.2" "2245.4" "2384.0" "2353.1" "2520.8" "2325.7" "2327.3" "2426.4" "1497.1" "" "" "" "" "" "" "" "" "" "" "2064.4" "1925.1" "2031.0" "2327.1" "1941.8" "2520.8" "1741.4" "2055.6" "2171.2" "534.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5156803787758571728" "False" "High" "IsMasterProtein" "Q14444" "Caprin-1 OS=Homo sapiens OX=9606 GN=CAPRIN1 PE=1 SV=2" "0.000" "False" "75.071" "18" "12" "43" "12" "709" "78.3" "5.25" "169.33" "12" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf12287, Pf18293" "4076" "ENSG00000135387" "CAPRIN1" "A6NMY7; D3DR06; hsa:4076; Q14444; Q15074; Q6IMN4; Q6IMN7; Q9BV09" "" "" "0" "0" "0.911" "0.951" "0.962" "0.956" "0.926" "0.917" "0.970" "0.943" "0.723" "5404.3" "4923.8" "5138.2" "5199.3" "5166.7" "5003.7" "4957.4" "5244.1" "5094.1" "3906.1" "" "" "" "" "" "" "" "" "" "" "4859.0" "3984.2" "4647.7" "5075.2" "4263.7" "5003.7" "3712.0" "4631.9" "4558.2" "1394.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2767928129327746769" "False" "High" "IsMasterProtein" "O14950" "Myosin regulatory light chain 12B OS=Homo sapiens OX=9606 GN=MYL12B PE=1 SV=2" "0.000" "False" "75.057" "63" "10" "43" "10" "172" "19.8" "4.84" "157.87" "10" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08976, Pf13499" "103910; 10627" "ENSG00000118680" "MYL12B" "D3DUH6; hsa:103910; O14950; Q13182; Q7Z5Z4" "Thyroid stimulating hormone (TSH) signaling pathway; Focal adhesion" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "9" "0" "1.000" "1.346" "0.960" "1.065" "1.363" "1.030" "1.108" "1.304" "1.288" "2409.4" "2409.7" "3242.6" "2311.9" "2565.4" "3283.9" "2482.9" "2670.2" "3140.8" "3103.5" "" "" "" "" "" "" "" "" "" "" "2166.3" "1949.9" "2933.1" "2256.8" "2117.0" "3283.9" "1859.1" "2358.5" "2810.4" "1107.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2644989191906863874" "False" "High" "IsMasterProtein" "Q6ZSZ5" "Rho guanine nucleotide exchange factor 18 OS=Homo sapiens OX=9606 GN=ARHGEF18 PE=1 SV=4" "0.000" "False" "75.027" "22" "20" "23" "19" "1361" "151.5" "6.33" "93.74" "20" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00621, Pf17838" "23370" "ENSG00000104880" "ARHGEF18" "A8MV62; B5ME81; hsa:23370; I3L1I5; O60274; Q6DD92; Q6ZSZ5" "" "RHOA GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)" "5" "0" "1.129" "1.043" "1.037" "1.109" "1.078" "1.418" "1.089" "1.124" "1.600" "1125.7" "1270.9" "1173.7" "1166.8" "1248.2" "1214.0" "1596.8" "1225.7" "1265.2" "1801.2" "" "" "" "" "" "" "" "" "" "" "1012.1" "1028.3" "1061.7" "1139.0" "1030.0" "1214.0" "1195.6" "1082.7" "1132.1" "643.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4375562830836446683" "False" "High" "IsMasterProtein" "Q15386" "Ubiquitin-protein ligase E3C OS=Homo sapiens OX=9606 GN=UBE3C PE=1 SV=3" "0.000" "False" "75.023" "22" "18" "23" "18" "1083" "123.8" "6.71" "96.96" "18" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632" "9690" "ENSG00000009335" "UBE3C" "A4D235; A6NCP3; hsa:9690; Q15386; Q8TC15; Q96CR4; Q9UDU3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.001" "0.970" "1.006" "0.991" "0.991" "0.972" "0.989" "0.991" "0.853" "1462.9" "1463.7" "1418.8" "1471.8" "1449.9" "1450.3" "1421.6" "1446.4" "1449.7" "1247.6" "" "" "" "" "" "" "" "" "" "" "1315.3" "1184.4" "1283.4" "1436.6" "1196.5" "1450.3" "1064.5" "1277.5" "1297.2" "445.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7175242905837588229" "False" "High" "IsMasterProtein" "O95747" "Serine/threonine-protein kinase OSR1 OS=Homo sapiens OX=9606 GN=OXSR1 PE=1 SV=1" "0.000" "False" "74.933" "30" "13" "28" "12" "527" "58.0" "6.43" "107.24" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "9943" "ENSG00000172939" "OXSR1" "hsa:9943; O95747; Q3LR53; Q7Z501; Q9UPQ1" "" "" "0" "0" "1.039" "1.009" "0.980" "1.015" "0.972" "1.022" "1.044" "1.038" "0.967" "1827.1" "1897.9" "1843.1" "1789.7" "1854.2" "1776.9" "1866.9" "1907.7" "1896.4" "1766.7" "" "" "" "" "" "" "" "" "" "" "1642.8" "1535.7" "1667.1" "1747.0" "1530.1" "1776.9" "1397.9" "1685.0" "1696.9" "630.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6442873191784740439" "False" "High" "IsMasterProtein" "Q9BXW7" "Haloacid dehalogenase-like hydrolase domain-containing 5 OS=Homo sapiens OX=9606 GN=HDHD5 PE=1 SV=1" "0.000" "False" "74.921" "43" "12" "28" "12" "423" "46.3" "8.13" "115.35" "12" "other metabolic processes" "mitochondrion" "" "Pf13344" "27440" "ENSG00000069998" "HDHD5" "B2RCK5; Q9BXW7; Q9BXW8; Q9NWA8; Q9NX41" "" "" "0" "0" "0.972" "0.999" "0.964" "1.023" "0.902" "1.007" "0.986" "0.987" "0.906" "1311.9" "1275.4" "1310.2" "1264.6" "1341.7" "1184.0" "1320.5" "1293.1" "1294.3" "1189.0" "" "" "" "" "" "" "" "" "" "" "1179.5" "1032.0" "1185.1" "1234.4" "1107.2" "1184.0" "988.8" "1142.2" "1158.2" "424.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "513185524036398277" "False" "High" "IsMasterProtein" "Q9NUQ3" "Gamma-taxilin OS=Homo sapiens OX=9606 GN=TXLNG PE=1 SV=2" "0.000" "False" "74.908" "40" "18" "33" "17" "528" "60.5" "7.52" "112.91" "18" "cell cycle OR cell proliferation;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf09728" "55787" "ENSG00000086712" "TXLNG" "hsa:55787; Q2KQ75; Q5JNZ7; Q9NUQ3; Q9P0X1" "" "" "0" "0" "0.890" "0.940" "0.941" "0.968" "0.982" "0.950" "0.958" "0.964" "0.804" "2654.8" "2363.6" "2494.3" "2497.4" "2570.9" "2606.3" "2522.5" "2542.3" "2558.4" "2133.6" "" "" "" "" "" "" "" "" "" "" "2386.9" "1912.5" "2256.1" "2437.9" "2121.6" "2606.3" "1888.8" "2245.5" "2289.2" "761.6" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5264367170864335030" "False" "High" "IsMasterProtein" "Q96K76" "Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens OX=9606 GN=USP47 PE=1 SV=3" "0.000" "False" "74.856" "16" "17" "23" "17" "1375" "157.2" "5.08" "84.07" "17" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf19718" "55031" "ENSG00000170242" "USP47" "B3KXF5; E9PM46; hsa:55031; Q658U0; Q86Y73; Q8TEP6; Q96K76; Q9BWI0; Q9NWN1" "" "Ub-specific processing proteases" "1" "0" "0.995" "0.980" "0.953" "0.977" "0.934" "0.967" "0.945" "1.028" "1.697" "1924.5" "1915.5" "1885.4" "1833.8" "1880.0" "1797.8" "1861.7" "1818.7" "1978.4" "3265.6" "" "" "" "" "" "" "" "" "" "" "1730.3" "1549.9" "1705.4" "1790.1" "1551.4" "1797.8" "1394.0" "1606.4" "1770.3" "1165.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "777273144622755670" "False" "High" "IsMasterProtein" "P51649" "Succinate-semialdehyde dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH5A1 PE=1 SV=2" "0.000" "False" "74.838" "34" "15" "33" "15" "535" "57.2" "8.28" "120.97" "15" "cell-cell signaling;other metabolic processes;developmental processes" "mitochondrion;other cell component" "other molecular function" "Pf00171" "7915" "ENSG00000112294" "ALDH5A1" "B2RD26; G5E949; hsa:7915; P51649; Q546H9; Q8N3W6" "Fragile X syndrome" "Degradation of GABA" "2" "0" "1.026" "0.992" "0.983" "1.034" "0.972" "0.986" "1.031" "1.003" "0.792" "3402.2" "3490.6" "3373.4" "3344.6" "3517.8" "3305.7" "3355.2" "3509.0" "3413.6" "2693.9" "" "" "" "" "" "" "" "" "" "" "3058.9" "2824.5" "3051.3" "3264.8" "2902.9" "3305.7" "2512.3" "3099.4" "3054.4" "961.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6508547570803101910" "False" "High" "IsMasterProtein" "Q00169" "Phosphatidylinositol transfer protein alpha isoform OS=Homo sapiens OX=9606 GN=PITPNA PE=1 SV=2" "0.000" "False" "74.826" "74" "21" "42" "17" "270" "31.8" "6.55" "136.57" "21" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "5306" "ENSG00000174238" "PITPNA" "hsa:5306; Q00169" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Role of second messengers in netrin-1 signaling" "2" "3" "1.024" "1.009" "0.988" "1.030" "0.979" "0.995" "0.996" "1.026" "0.793" "4254.5" "4357.5" "4294.2" "4201.4" "4380.5" "4163.7" "4234.6" "4238.4" "4364.8" "3374.6" "" "" "" "" "" "" "" "" "" "" "3825.2" "3525.9" "3884.3" "4101.1" "3614.9" "4163.7" "3170.8" "3743.6" "3905.6" "1204.6" "19" "19" "19" "19" "19" "19" "19" "19" "19" "19" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1086525266732812690" "False" "High" "IsMasterProtein" "Q9Y5P4" "Ceramide transfer protein OS=Homo sapiens OX=9606 GN=CERT1 PE=1 SV=1" "0.000" "False" "74.737" "32" "18" "23" "18" "624" "70.8" "5.48" "86.34" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus" "transporter activity;kinase activity;other molecular function" "Pf00169, Pf01852" "10087" "ENSG00000113163" "CERT1" "A8K7S2; B3KUB7; hsa:10087; Q53YV1; Q53YV2; Q96Q85; Q96Q88; Q9H2S7; Q9H2S8; Q9Y5P4" "Sphingolipid pathway" "" "1" "0" "1.032" "1.002" "1.025" "0.990" "1.007" "1.029" "0.976" "0.996" "0.891" "1888.7" "1949.9" "1892.0" "1936.1" "1870.5" "1901.7" "1944.3" "1842.9" "1880.9" "1683.5" "" "" "" "" "" "" "" "" "" "" "1698.1" "1577.8" "1711.4" "1889.9" "1543.6" "1901.7" "1455.9" "1627.8" "1683.0" "601.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3853404113387134869" "False" "High" "IsMasterProtein" "Q9UK59" "Lariat debranching enzyme OS=Homo sapiens OX=9606 GN=DBR1 PE=1 SV=2" "0.000" "False" "74.716" "33" "15" "26" "15" "544" "61.5" "5.47" "100.09" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00149, Pf05011" "51163" "ENSG00000138231" "DBR1" "hsa:51163; Q96GH0; Q9NXQ6; Q9UK59" "" "" "0" "0" "1.016" "1.065" "1.041" "1.035" "1.027" "1.029" "1.026" "1.052" "0.879" "1441.8" "1464.6" "1535.6" "1500.6" "1492.3" "1481.4" "1483.8" "1479.1" "1517.4" "1267.5" "" "" "" "" "" "" "" "" "" "" "1296.3" "1185.1" "1389.0" "1464.8" "1231.4" "1481.4" "1111.0" "1306.4" "1357.8" "452.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4520162396586865811" "False" "High" "IsMasterProtein" "P51148" "Ras-related protein Rab-5C OS=Homo sapiens OX=9606 GN=RAB5C PE=1 SV=2" "0.000" "False" "74.646" "72" "10" "24" "7" "216" "23.5" "8.41" "98.44" "10" "transport" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5878" "ENSG00000108774" "RAB5C" "F8W1H5; hsa:5878; P51148; Q6FH55; Q9P0Y5" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Golgi Associated Vesicle Biogenesis; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "10" "3" "1.050" "1.029" "1.009" "1.040" "0.992" "0.995" "1.008" "1.069" "0.846" "1473.5" "1547.3" "1515.7" "1487.2" "1531.9" "1461.6" "1466.6" "1485.5" "1575.1" "1246.0" "" "" "" "" "" "" "" "" "" "" "1324.8" "1252.0" "1371.0" "1451.7" "1264.1" "1461.6" "1098.1" "1312.1" "1409.4" "444.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516801179277526941" "False" "High" "IsMasterProtein" "Q9HB71" "Calcyclin-binding protein OS=Homo sapiens OX=9606 GN=CACYBP PE=1 SV=2" "0.000" "False" "74.641" "61" "14" "45" "13" "228" "26.2" "8.25" "172.24" "14" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf04969, Pf05002, Pf09032" "27101" "ENSG00000116161" "CACYBP" "B2ZWH2; B3KSF1; hsa:27101; O60666; Q5R370; Q5R371; Q9HB71" "Gastric cancer network 2" "" "1" "1" "0.945" "1.006" "1.012" "0.920" "0.994" "0.928" "0.955" "0.935" "0.817" "5361.0" "5067.9" "5394.3" "5423.6" "4933.4" "5331.2" "4977.4" "5118.1" "5010.8" "4377.5" "" "" "" "" "" "" "" "" "" "" "4820.1" "4100.8" "4879.4" "5294.1" "4071.2" "5331.2" "3727.0" "4520.6" "4483.7" "1562.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1619484696952214884" "False" "High" "IsMasterProtein" "P24534" "Elongation factor 1-beta OS=Homo sapiens OX=9606 GN=EEF1B2 PE=1 SV=3" "0.000" "False" "74.621" "44" "9" "51" "6" "225" "24.7" "4.67" "208.45" "9" "protein metabolism;other metabolic processes" "cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00736, Pf10587" "1933" "ENSG00000114942; ENSG00000283391" "EEF1B2" "A8K795; hsa:1933; P24534; Q6IBH9" "Translation factors" "Eukaryotic Translation Elongation" "2" "0" "0.886" "0.917" "0.974" "0.904" "0.892" "0.921" "0.987" "0.930" "0.816" "6094.0" "5398.0" "5588.0" "5935.7" "5508.1" "5434.2" "5609.6" "6017.0" "5668.8" "4974.3" "" "" "" "" "" "" "" "" "" "" "5479.1" "4367.9" "5054.6" "5794.1" "4545.4" "5434.2" "4200.3" "5314.6" "5072.4" "1775.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641944312381893453" "False" "High" "IsMasterProtein" "Q8IYB7" "DIS3-like exonuclease 2 OS=Homo sapiens OX=9606 GN=DIS3L2 PE=1 SV=4" "0.000" "False" "74.577" "28" "24" "27" "24" "885" "99.2" "6.10" "93.43" "24" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00773, Pf17216, Pf17849, Pf17877" "129563" "ENSG00000144535" "DIS3L2" "hsa:129563; Q53S79; Q580W6; Q5XKH0; Q69YG5; Q6AW99; Q7Z4T6; Q8IYB7; Q8N9K9" "" "Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "1" "0" "0.979" "0.943" "0.925" "0.964" "0.946" "0.965" "0.956" "0.972" "0.882" "2185.0" "2138.9" "2060.5" "2021.2" "2105.3" "2067.2" "2109.1" "2089.8" "2123.0" "1926.3" "" "" "" "" "" "" "" "" "" "" "1964.5" "1730.7" "1863.8" "1973.0" "1737.3" "2067.2" "1579.2" "1845.8" "1899.7" "687.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1669243048092869257" "False" "High" "IsMasterProtein" "Q8WU90" "Zinc finger CCCH domain-containing protein 15 OS=Homo sapiens OX=9606 GN=ZC3H15 PE=1 SV=1" "0.000" "False" "74.544" "47" "20" "34" "20" "426" "48.6" "5.31" "111.26" "20" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00642, Pf16543" "55854" "ENSG00000065548" "ZC3H15" "B4DMW2; D3DPG7; hsa:55854; Q5QTQ4; Q8WU90; Q8WZ06; Q9NUZ3; Q9NZ37; Q9P079" "VEGFA-VEGFR2 signaling" "Protein hydroxylation" "2" "0" "0.938" "0.937" "0.947" "0.972" "0.915" "0.929" "1.014" "0.999" "0.781" "3885.0" "3644.3" "3639.3" "3679.5" "3775.2" "3554.3" "3611.0" "3940.0" "3879.4" "3033.8" "" "" "" "" "" "" "" "" "" "" "3493.0" "2948.8" "3291.9" "3591.7" "3115.4" "3554.3" "2703.8" "3480.1" "3471.2" "1083.0" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711060710327679778" "False" "High" "IsMasterProtein" "O75886" "Signal transducing adapter molecule 2 OS=Homo sapiens OX=9606 GN=STAM2 PE=1 SV=1" "0.000" "False" "74.506" "29" "14" "23" "12" "525" "58.1" "5.07" "87.05" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "10254" "ENSG00000115145" "STAM2" "A8K8A0; D3DPA1; hsa:10254; O75886; Q7LDQ0; Q9UF58" "EGF/EGFR signaling pathway" "Ub-specific processing proteases; Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "9" "1" "0.987" "0.962" "1.044" "0.983" "1.243" "1.022" "1.021" "0.999" "0.892" "2401.4" "2369.7" "2310.2" "2507.2" "2361.8" "2985.0" "2454.6" "2452.9" "2398.9" "2141.5" "" "" "" "" "" "" "" "" "" "" "2159.1" "1917.5" "2089.7" "2447.4" "1949.0" "2985.0" "1837.9" "2166.5" "2146.5" "764.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2576467063852337379" "False" "High" "IsMasterProtein" "Q12912" "Inositol 1,4,5-triphosphate receptor associated 2 OS=Homo sapiens OX=9606 GN=IRAG2 PE=1 SV=3" "0.000" "False" "74.434" "35" "19" "28" "19" "555" "62.1" "5.85" "95.96" "19" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf05781" "4033" "ENSG00000118308" "IRAG2" "A0AVM2; B4E077; hsa:4033; Q12912; Q8N301" "" "Neutrophil degranulation" "1" "0" "0.963" "0.859" "0.993" "1.037" "0.866" "1.132" "0.931" "0.810" "0.763" "3065.8" "2951.0" "2634.3" "3044.5" "3180.2" "2655.4" "3469.2" "2854.7" "2484.2" "2338.8" "" "" "" "" "" "" "" "" "" "" "2756.4" "2387.8" "2382.8" "2971.8" "2624.4" "2655.4" "2597.6" "2521.5" "2222.8" "834.9" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5615919369887998349" "False" "High" "IsMasterProtein" "P49903" "Selenide, water dikinase 1 OS=Homo sapiens OX=9606 GN=SEPHS1 PE=1 SV=2" "0.000" "False" "74.409" "43" "11" "26" "10" "392" "42.9" "5.97" "108.02" "11" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22929" "ENSG00000086475" "SEPHS1" "B4DWK0; D3DRS9; D6PSQ9; hsa:22929; P49903; Q5T5U8; Q5T5U9; Q9BVT4" "" "" "0" "0" "1.020" "1.031" "1.046" "1.051" "1.015" "1.050" "1.052" "1.021" "0.782" "1496.5" "1527.0" "1543.0" "1565.8" "1573.0" "1518.4" "1571.6" "1574.6" "1527.4" "1170.2" "" "" "" "" "" "" "" "" "" "" "1345.5" "1235.6" "1395.7" "1528.5" "1298.0" "1518.4" "1176.7" "1390.8" "1366.7" "417.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7726317818688943966" "False" "High" "IsMasterProtein" "Q9NQC3" "Reticulon-4 OS=Homo sapiens OX=9606 GN=RTN4 PE=1 SV=2" "0.000" "False" "74.405" "18" "14" "22" "14" "1192" "129.9" "4.50" "91.43" "14" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02453" "57142" "ENSG00000115310" "RTN4" "O94962; Q7L7Q5; Q7L7Q6; Q7L7Q8; Q8IUA4; Q96B16; Q9BXG5; Q9H212; Q9H3I3; Q9NQC3; Q9UQ42; Q9Y293; Q9Y2Y7; Q9Y5U6" "Alzheimer's disease and miRNA effects; Spinal cord injury; 22q11.2 copy number variation syndrome; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; 13q12.12 copy number variation" "Axonal growth inhibition (RHOA activation)" "7" "0" "1.028" "0.968" "1.013" "1.034" "1.015" "1.043" "1.022" "0.974" "0.906" "1702.9" "1751.2" "1648.7" "1725.3" "1760.0" "1728.4" "1776.2" "1740.4" "1659.3" "1543.0" "" "" "" "" "" "" "" "" "" "" "1531.1" "1417.0" "1491.3" "1684.1" "1452.4" "1728.4" "1330.0" "1537.2" "1484.7" "550.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8133937274084103067" "False" "High" "IsMasterProtein" "P28074" "Proteasome subunit beta type-5 OS=Homo sapiens OX=9606 GN=PSMB5 PE=1 SV=3" "0.000" "False" "74.271" "43" "10" "32" "10" "263" "28.5" "6.92" "128.62" "10" "protein metabolism;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00227" "5693" "ENSG00000100804" "PSMB5" "B2R4N9; B4DUM9; D3DS43; E9PAV2; hsa:5693; P28074; Q16242; Q6PEW2; Q7Z3B5; Q86T01; Q9TNN9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Asymmetric localization of PCP proteins; Degradation of DVL; ER-Phagosome pathway; MAPK6/MAPK4 signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Degradation of AXIN; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.033" "1.085" "1.017" "0.978" "0.955" "1.014" "0.963" "1.055" "0.795" "2527.1" "2610.1" "2742.8" "2569.5" "2472.7" "2412.9" "2562.5" "2434.0" "2665.4" "2008.9" "" "" "" "" "" "" "" "" "" "" "2272.1" "2112.0" "2480.9" "2508.2" "2040.5" "2412.9" "1918.8" "2149.9" "2385.0" "717.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "92352165089450524" "False" "High" "IsMasterProtein" "O15355" "Protein phosphatase 1G OS=Homo sapiens OX=9606 GN=PPM1G PE=1 SV=1" "0.000" "False" "74.265" "33" "14" "24" "14" "546" "59.2" "4.36" "100.72" "14" "protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00481" "5496" "ENSG00000115241" "PPM1G" "hsa:5496; O15355" "VEGFA-VEGFR2 signaling; mRNA processing" "" "2" "0" "0.975" "1.174" "0.906" "0.923" "1.095" "0.852" "0.880" "1.172" "2.357" "2011.8" "1960.8" "2362.7" "1822.8" "1857.7" "2202.3" "1713.5" "1770.8" "2357.7" "4742.6" "" "" "" "" "" "" "" "" "" "" "1808.8" "1586.6" "2137.1" "1779.3" "1533.0" "2202.3" "1283.0" "1564.1" "2109.6" "1693.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7722178459817833286" "False" "High" "IsMasterProtein" "P61970" "Nuclear transport factor 2 OS=Homo sapiens OX=9606 GN=NUTF2 PE=1 SV=1" "0.000" "False" "74.157" "69" "5" "31" "5" "127" "14.5" "5.38" "133.54" "5" "transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02136" "10204" "ENSG00000102898" "NUTF2" "B2R4G7; hsa:10204; P13662; P61970; Q6IB67" "" "" "0" "0" "1.008" "0.956" "1.083" "1.039" "0.993" "1.081" "1.086" "1.009" "0.794" "2540.1" "2559.9" "2428.1" "2750.9" "2639.6" "2523.4" "2745.6" "2758.5" "2562.9" "2017.0" "" "" "" "" "" "" "" "" "" "" "2283.8" "2071.4" "2196.3" "2685.3" "2178.2" "2523.4" "2055.8" "2436.5" "2293.3" "720.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7309351128836490355" "False" "High" "IsMasterProtein" "P26583" "High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2" "0.000" "False" "74.117" "50" "11" "54" "9" "209" "24.0" "7.81" "174.46" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "3148" "ENSG00000164104" "HMGB2" "B2R4K8; D3DP37; hsa:3148; P26583; Q5U072" "Retinoblastoma gene in cancer; Ectoderm differentiation; Ectoderm differentiation" "Apoptosis induced DNA fragmentation" "4" "0" "0.948" "0.881" "0.999" "0.943" "0.960" "0.936" "1.034" "0.917" "0.762" "4519.5" "4285.8" "3982.8" "4512.9" "4260.4" "4340.9" "4229.6" "4673.7" "4145.3" "3442.5" "" "" "" "" "" "" "" "" "" "" "4063.5" "3467.9" "3602.6" "4405.3" "3515.8" "4340.9" "3167.1" "4128.1" "3709.2" "1228.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1738440604026587204" "False" "High" "IsMasterProtein" "P60510" "Serine/threonine-protein phosphatase 4 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP4C PE=1 SV=1" "0.000" "False" "73.993" "52" "12" "22" "10" "307" "35.1" "5.06" "92.57" "12" "DNA metabolism;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5531" "ENSG00000149923" "PPP4C" "hsa:5531; P33172; P60510" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "1.042" "1.015" "1.054" "1.120" "1.026" "1.033" "1.038" "1.051" "0.980" "1182.8" "1232.3" "1200.4" "1246.7" "1324.5" "1213.0" "1221.6" "1227.7" "1242.7" "1159.7" "" "" "" "" "" "" "" "" "" "" "1063.4" "997.1" "1085.8" "1217.0" "1093.0" "1213.0" "914.7" "1084.4" "1112.0" "414.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4516016884332694472" "False" "High" "IsMasterProtein" "O60361" "Putative nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME2P1 PE=5 SV=1" "0.000" "False" "73.991" "66" "8" "60" "1" "137" "15.5" "8.57" "207.54" "8" "other metabolic processes;other biological processes" "" "kinase activity;other molecular function" "Pf00334" "" "" "NME2P1" "O60361" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.010" "1.137" "1.099" "1.087" "0.888" "0.937" "0.947" "1.141" "0.701" "432.4" "436.7" "491.9" "475.4" "469.9" "383.8" "405.3" "409.3" "493.2" "303.1" "" "" "" "" "" "" "" "" "" "" "388.8" "353.3" "444.9" "464.0" "387.7" "383.8" "303.5" "361.5" "441.3" "108.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8481404637455697567" "False" "High" "IsMasterProtein" "Q9C0B1" "Alpha-ketoglutarate-dependent dioxygenase FTO OS=Homo sapiens OX=9606 GN=FTO PE=1 SV=3" "0.000" "False" "73.905" "45" "20" "26" "20" "505" "58.2" "5.22" "92.72" "20" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12933, Pf12934" "79068" "ENSG00000140718" "FTO" "A2RUH1; B2RNS0; hsa:79068; Q0P676; Q7Z785; Q9C0B1" "FTO obesity variant mechanism" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.999" "1.014" "1.000" "1.029" "0.993" "0.992" "0.994" "0.992" "0.923" "1809.0" "1806.8" "1834.9" "1808.1" "1861.8" "1796.0" "1793.7" "1797.6" "1794.8" "1670.3" "" "" "" "" "" "" "" "" "" "" "1626.4" "1462.0" "1659.7" "1765.0" "1536.4" "1796.0" "1343.1" "1587.7" "1606.0" "596.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3678214923131327318" "False" "High" "IsMasterProtein" "Q96RQ3" "Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=MCCC1 PE=1 SV=3" "0.000" "False" "73.872" "29" "14" "21" "14" "725" "80.4" "7.78" "83.22" "14" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00289, Pf00364, Pf02785, Pf02786" "56922" "ENSG00000078070" "MCCC1" "hsa:56922; Q59ES4; Q96RQ3; Q9H959; Q9NS97" "Amino acid metabolism" "Branched-chain amino acid catabolism; Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "4" "0" "0.896" "0.874" "0.931" "0.932" "0.834" "0.902" "0.896" "0.874" "0.854" "1662.0" "1490.0" "1453.2" "1546.6" "1548.5" "1386.6" "1499.8" "1489.0" "1453.1" "1419.5" "" "" "" "" "" "" "" "" "" "" "1494.3" "1205.6" "1314.5" "1509.7" "1277.9" "1386.6" "1123.0" "1315.2" "1300.2" "506.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222820814571899525" "False" "High" "IsMasterProtein" "Q9UJ70" "N-acetyl-D-glucosamine kinase OS=Homo sapiens OX=9606 GN=NAGK PE=1 SV=4" "0.000" "False" "73.697" "51" "14" "30" "14" "344" "37.4" "6.24" "122.23" "14" "other metabolic processes;stress response;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01869" "55577" "ENSG00000124357" "NAGK" "B4DLZ5; hsa:55577; Q53HD5; Q6IA84; Q9BS29; Q9BVP0; Q9NV37; Q9UJ70" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.066" "0.993" "1.011" "1.141" "1.081" "1.103" "1.049" "1.076" "0.874" "1948.9" "2078.4" "1935.7" "1969.6" "2223.8" "2106.1" "2150.4" "2044.0" "2097.5" "1703.7" "" "" "" "" "" "" "" "" "" "" "1752.2" "1681.8" "1750.9" "1922.6" "1835.1" "2106.1" "1610.1" "1805.4" "1876.8" "608.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4839945324263831738" "False" "High" "IsMasterProtein" "Q9NTX5" "Ethylmalonyl-CoA decarboxylase OS=Homo sapiens OX=9606 GN=ECHDC1 PE=1 SV=2" "0.000" "False" "73.673" "44" "11" "35" "11" "307" "33.7" "8.21" "146.28" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf00378" "55862" "ENSG00000093144" "ECHDC1" "A6NFJ5; B7Z8S0; E9PEN7; E9PR31; F8W851; hsa:55862; Q5TEF6; Q5TEF7; Q5TEG0; Q5TEG4; Q9NTX5; Q9NZ30; V9HW18" "Fatty acid biosynthesis" "" "1" "0" "0.994" "0.980" "0.950" "1.013" "0.956" "0.952" "0.989" "0.999" "0.765" "3457.8" "3435.5" "3390.1" "3285.6" "3502.3" "3306.9" "3291.7" "3419.8" "3454.8" "2645.8" "" "" "" "" "" "" "" "" "" "" "3108.9" "2779.9" "3066.5" "3207.2" "2890.2" "3306.9" "2464.8" "3020.6" "3091.4" "944.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174373993236338878" "False" "High" "IsMasterProtein" "Q15233" "Non-POU domain-containing octamer-binding protein OS=Homo sapiens OX=9606 GN=NONO PE=1 SV=4" "0.000" "False" "73.651" "29" "14" "35" "12" "471" "54.2" "8.95" "117.19" "14" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08075" "4841" "ENSG00000147140" "NONO" "B7Z4C2; D3DVV4; F5GYZ3; hsa:4841; O00201; P30807; Q12786; Q15233; Q9BQC5" "mRNA processing" "" "1" "0" "0.950" "0.935" "1.044" "0.982" "0.926" "0.987" "0.851" "0.936" "7.160" "1631.2" "1550.2" "1525.2" "1703.4" "1601.1" "1510.6" "1610.6" "1387.9" "1527.4" "11679.1" "" "" "" "" "" "" "" "" "" "" "1466.6" "1254.4" "1379.6" "1662.7" "1321.3" "1510.6" "1206.0" "1225.9" "1366.7" "4169.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4125655909395712746" "False" "High" "IsMasterProtein" "Q8IUR7" "Armadillo repeat-containing protein 8 OS=Homo sapiens OX=9606 GN=ARMC8 PE=1 SV=2" "0.000" "False" "73.636" "28" "17" "25" "17" "673" "75.5" "6.73" "95.02" "17" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00514" "25852" "ENSG00000114098" "ARMC8" "A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; hsa:25852; Q6PIL2; Q8IUR7; Q96D19; Q96HZ5; Q9NV02; Q9NV94; Q9Y4R9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "1.004" "1.060" "0.967" "1.027" "1.012" "1.029" "1.032" "1.008" "0.926" "2312.3" "2321.6" "2450.1" "2237.0" "2375.7" "2339.5" "2378.4" "2385.6" "2330.3" "2141.7" "" "" "" "" "" "" "" "" "" "" "2079.0" "1878.6" "2216.2" "2183.6" "1960.5" "2339.5" "1780.9" "2107.1" "2085.1" "764.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421674880825804013" "False" "High" "IsMasterProtein" "Q96C19" "EF-hand domain-containing protein D2 OS=Homo sapiens OX=9606 GN=EFHD2 PE=1 SV=1" "0.000" "False" "73.554" "45" "11" "44" "11" "240" "26.7" "5.20" "150.95" "11" "" "other membranes" "other molecular function" "Pf21008" "79180" "ENSG00000142634" "EFHD2" "hsa:79180; Q5JYW9; Q96C19" "" "RHOD GTPase cycle" "1" "0" "0.945" "0.956" "0.965" "0.994" "0.967" "0.964" "0.952" "0.989" "0.805" "4153.0" "3923.7" "3970.3" "4009.5" "4128.1" "4016.6" "4004.9" "3954.8" "4107.4" "3343.5" "" "" "" "" "" "" "" "" "" "" "3734.0" "3174.9" "3591.3" "3913.8" "3406.6" "4016.6" "2998.7" "3493.2" "3675.3" "1193.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4968571585111953171" "False" "High" "IsMasterProtein" "P55036" "26S proteasome non-ATPase regulatory subunit 4 OS=Homo sapiens OX=9606 GN=PSMD4 PE=1 SV=1" "0.000" "False" "73.547" "38" "10" "30" "10" "377" "40.7" "4.79" "118.81" "10" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02809, Pf13519" "5710" "ENSG00000159352" "PSMD4" "D3DV16; hsa:5710; P55036; Q5VWC5; Q9NS92" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; VEGFA-VEGFR2 signaling; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.954" "0.961" "0.964" "0.940" "0.971" "0.974" "1.006" "0.968" "0.815" "3656.3" "3486.4" "3514.3" "3524.6" "3435.1" "3550.8" "3561.1" "3676.9" "3538.8" "2978.9" "" "" "" "" "" "" "" "" "" "" "3287.4" "2821.1" "3178.8" "3440.5" "2834.7" "3550.8" "2666.4" "3247.7" "3166.5" "1063.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7171410217774938332" "False" "High" "IsMasterProtein" "Q96T51" "RUN and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RUFY1 PE=1 SV=2" "0.000" "False" "73.545" "31" "20" "26" "19" "708" "79.8" "5.74" "93.54" "20" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "80230" "ENSG00000176783; ENSG00000284260" "RUFY1" "hsa:80230; Q59FF3; Q71S93; Q96T51; Q9H6I3" "" "Synthesis of PIPs at the plasma membrane" "1" "0" "1.057" "1.091" "1.000" "1.123" "1.088" "1.061" "1.089" "1.093" "1.284" "2220.7" "2346.3" "2422.5" "2219.9" "2494.3" "2417.0" "2356.4" "2418.2" "2427.3" "2852.1" "" "" "" "" "" "" "" "" "" "" "1996.6" "1898.6" "2191.3" "2166.9" "2058.3" "2417.0" "1764.4" "2135.9" "2172.0" "1018.1" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6941898924238947203" "False" "High" "IsMasterProtein" "P52565" "Rho GDP-dissociation inhibitor 1 OS=Homo sapiens OX=9606 GN=ARHGDIA PE=1 SV=3" "0.000" "False" "73.542" "49" "13" "53" "13" "204" "23.2" "5.11" "180.74" "13" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf02115" "396" "ENSG00000141522" "ARHGDIA" "A8MXW0; B2R5X1; B4DDD3; B4DUV9; hsa:396; P52565; Q6IBM5" "Ciliary landscape; Nephrotic syndrome; Vasopressin-regulated water reabsorption" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOH GTPase cycle; Axonal growth stimulation; Axonal growth inhibition (RHOA activation)" "12" "0" "1.037" "1.010" "1.101" "0.989" "1.060" "1.015" "1.029" "1.000" "0.848" "4935.6" "5117.1" "4985.5" "5431.7" "4880.0" "5231.6" "5008.8" "5076.2" "4935.7" "4183.6" "" "" "" "" "" "" "" "" "" "" "4437.6" "4140.5" "4509.5" "5302.1" "4027.1" "5231.6" "3750.5" "4483.7" "4416.4" "1493.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6062730820723703914" "False" "High" "IsMasterProtein" "P82094" "TATA element modulatory factor OS=Homo sapiens OX=9606 GN=TMF1 PE=1 SV=2" "0.000" "False" "73.476" "20" "20" "22" "20" "1093" "122.8" "4.92" "86.74" "20" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf12325, Pf12329" "7110" "ENSG00000144747" "TMF1" "B7ZLJ2; hsa:7110; P82094; Q17R87; Q59GK0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.994" "1.047" "1.001" "1.059" "1.043" "1.044" "1.033" "1.041" "0.778" "2264.9" "2252.1" "2370.6" "2267.6" "2397.9" "2362.0" "2364.8" "2340.7" "2357.9" "1761.4" "" "" "" "" "" "" "" "" "" "" "2036.4" "1822.3" "2144.2" "2213.5" "1978.8" "2362.0" "1770.7" "2067.5" "2109.9" "628.8" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120785921578449656" "False" "High" "IsMasterProtein" "A0A0B4J2D5" "Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial OS=Homo sapiens OX=9606 GN=GATD3B PE=5 SV=1" "0.000" "False" "73.454" "53" "11" "34" "11" "268" "28.1" "8.27" "149.87" "11" "" "mitochondrion" "" "" "8209" "" "GATD3B" "A0A0B4J2D5; A6NFJ6; A6NJY7; hsa:8209; O00650; O00660; O15011; O15012; P30042; P55346; P78474; Q92505; Q92507" "Gastric cancer network 1" "" "1" "0" "0.990" "0.981" "0.973" "1.047" "0.946" "0.995" "1.021" "0.975" "0.766" "3869.1" "3830.7" "3796.6" "3762.8" "4052.2" "3661.0" "3847.8" "3950.5" "3772.2" "2963.6" "" "" "" "" "" "" "" "" "" "" "3478.7" "3099.6" "3434.2" "3673.0" "3343.9" "3661.0" "2881.1" "3489.4" "3375.3" "1057.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000149413272750326" "False" "High" "IsMasterProtein" "Q15907" "Ras-related protein Rab-11B OS=Homo sapiens OX=9606 GN=RAB11B PE=1 SV=4" "0.000" "False" "73.383" "60" "12" "31" "12" "218" "24.5" "5.94" "120.57" "12" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "9230" "ENSG00000185236" "RAB11B" "A5YM50; B2R7I4; B4DMK0; D6W671; hsa:9230; Q15907; Q2YDT2; Q5U0I1; Q6FHR0; Q6FI42; Q8NI07" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy; Vasopressin-regulated water reabsorption" "RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "0.974" "1.026" "1.008" "1.011" "0.925" "1.007" "0.930" "0.986" "0.721" "3078.4" "2998.9" "3159.6" "3104.0" "3112.2" "2847.5" "3099.6" "2861.9" "3033.8" "2220.1" "" "" "" "" "" "" "" "" "" "" "2767.8" "2426.6" "2858.0" "3029.9" "2568.2" "2847.5" "2320.9" "2527.8" "2714.6" "792.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5200719085873833637" "False" "High" "IsMasterProtein" "Q8NFW8" "N-acylneuraminate cytidylyltransferase OS=Homo sapiens OX=9606 GN=CMAS PE=1 SV=2" "0.000" "False" "73.348" "44" "16" "26" "16" "434" "48.3" "7.93" "95.60" "16" "other metabolic processes" "nucleus" "other molecular function" "Pf02348" "55907" "ENSG00000111726" "CMAS" "hsa:55907; Q8NFW8; Q96AX5; Q9NQZ0" "Sialylation" "Sialic acid metabolism" "2" "0" "1.024" "1.090" "0.965" "0.971" "1.114" "0.968" "0.955" "1.078" "0.846" "1981.8" "2029.3" "2159.5" "1912.2" "1924.3" "2208.5" "1918.8" "1892.7" "2137.2" "1677.2" "" "" "" "" "" "" "" "" "" "" "1781.8" "1642.1" "1953.4" "1866.6" "1588.0" "2208.5" "1436.8" "1671.8" "1912.3" "598.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5527327330749920032" "False" "High" "IsMasterProtein" "P61019" "Ras-related protein Rab-2A OS=Homo sapiens OX=9606 GN=RAB2A PE=1 SV=1" "0.000" "False" "73.235" "76" "13" "28" "6" "212" "23.5" "6.54" "108.82" "13" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "5862" "ENSG00000104388" "RAB2A" "B2R5W8; B4DMQ5; hsa:5862; P08886; P61019" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Ciliary landscape" "RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "4" "7" "1.051" "1.003" "1.032" "1.067" "0.995" "1.083" "0.997" "1.023" "0.747" "2182.2" "2294.1" "2189.8" "2252.9" "2328.9" "2171.6" "2362.4" "2176.0" "2233.3" "1630.2" "" "" "" "" "" "" "" "" "" "" "1962.0" "1856.3" "1980.7" "2199.2" "1921.9" "2171.6" "1768.9" "1922.0" "1998.4" "581.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4969785199518402327" "False" "High" "IsMasterProtein" "Q13098" "COP9 signalosome complex subunit 1 OS=Homo sapiens OX=9606 GN=GPS1 PE=1 SV=4" "0.000" "False" "73.171" "36" "15" "37" "15" "491" "55.5" "6.74" "136.15" "15" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01399, Pf10602, Pf21151" "2873" "ENSG00000169727" "GPS1" "hsa:2873; Q13098; Q8NA10; Q9BWL1" "" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; RHOBTB1 GTPase cycle; DNA Damage Recognition in GG-NER" "5" "0" "1.040" "0.984" "1.020" "1.021" "0.994" "1.036" "1.042" "1.010" "0.817" "2333.9" "2426.8" "2297.7" "2381.1" "2382.2" "2320.0" "2418.1" "2432.4" "2357.8" "1905.7" "" "" "" "" "" "" "" "" "" "" "2098.4" "1963.7" "2078.4" "2324.3" "1965.8" "2320.0" "1810.6" "2148.5" "2109.8" "680.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5965687288212214297" "False" "High" "IsMasterProtein" "Q7L2H7" "Eukaryotic translation initiation factor 3 subunit M OS=Homo sapiens OX=9606 GN=EIF3M PE=1 SV=1" "0.000" "False" "73.138" "42" "13" "26" "13" "374" "42.5" "5.63" "104.60" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01399, Pf18005" "10480" "ENSG00000149100" "EIF3M" "A8K7X4; B4E2Q4; hsa:10480; O60735; Q2F836; Q53HL6; Q7L2H7; Q9BXW1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.047" "1.062" "0.983" "1.072" "1.019" "1.041" "1.030" "1.117" "1.191" "1936.2" "2027.6" "2055.8" "1904.0" "2075.7" "1973.6" "2016.1" "1993.6" "2161.9" "2306.8" "" "" "" "" "" "" "" "" "" "" "1740.8" "1640.6" "1859.6" "1858.6" "1712.9" "1973.6" "1509.6" "1760.9" "1934.5" "823.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7011076575076357199" "False" "High" "IsMasterProtein" "O00442" "RNA 3'-terminal phosphate cyclase OS=Homo sapiens OX=9606 GN=RTCA PE=1 SV=1" "0.000" "False" "73.059" "42" "12" "20" "12" "366" "39.3" "7.85" "79.35" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01137, Pf05189" "8634" "ENSG00000137996" "RTCA" "hsa:8634; O00442; Q5VVL5; Q5VVL6; Q96E99" "" "" "0" "0" "1.062" "0.988" "1.050" "1.087" "1.001" "1.040" "0.972" "1.053" "0.795" "1787.3" "1898.7" "1765.0" "1875.8" "1942.3" "1789.6" "1858.9" "1738.0" "1881.3" "1421.0" "" "" "" "" "" "" "" "" "" "" "1606.9" "1536.4" "1596.5" "1831.0" "1602.9" "1789.6" "1391.9" "1535.1" "1683.3" "507.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6701833234650983688" "False" "High" "IsMasterProtein" "O43865" "S-adenosylhomocysteine hydrolase-like protein 1 OS=Homo sapiens OX=9606 GN=AHCYL1 PE=1 SV=2" "0.000" "False" "73.026" "39" "20" "37" "9" "530" "58.9" "6.89" "118.93" "20" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00670, Pf05221" "10768" "ENSG00000168710" "AHCYL1" "B4E168; hsa:10768; O43865; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Regulation of insulin secretion; VEGFR2 mediated cell proliferation; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation" "12" "8" "0.994" "1.040" "0.969" "0.974" "0.964" "0.996" "0.947" "0.985" "0.943" "2300.2" "2287.1" "2391.4" "2228.9" "2240.8" "2217.4" "2291.8" "2178.9" "2265.3" "2168.7" "" "" "" "" "" "" "" "" "" "" "2068.1" "1850.6" "2163.1" "2175.7" "1849.1" "2217.4" "1716.0" "1924.6" "2027.0" "774.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200038646673232615" "False" "High" "IsMasterProtein" "Q9P287" "BRCA2 and CDKN1A-interacting protein OS=Homo sapiens OX=9606 GN=BCCIP PE=1 SV=1" "0.000" "False" "72.925" "49" "13" "28" "13" "314" "36.0" "4.61" "110.02" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "enzyme regulator activity;cytoskeletal activity" "Pf13862" "56647" "ENSG00000107949" "BCCIP" "B3KP45; hsa:56647; Q8ND15; Q96GC4; Q9P287; Q9P288" "" "" "0" "0" "0.960" "0.990" "0.995" "0.983" "1.053" "1.021" "1.059" "0.992" "0.859" "3294.5" "3163.1" "3262.3" "3279.3" "3239.3" "3469.1" "3363.0" "3489.4" "3268.1" "2830.0" "" "" "" "" "" "" "" "" "" "" "2962.1" "2559.5" "2950.9" "3201.1" "2673.1" "3469.1" "2518.2" "3082.1" "2924.3" "1010.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1761258682097812184" "False" "High" "IsMasterProtein" "Q9NS86" "LanC-like protein 2 OS=Homo sapiens OX=9606 GN=LANCL2 PE=1 SV=1" "0.000" "False" "72.874" "29" "11" "29" "11" "450" "50.8" "7.43" "110.15" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf05147" "55915" "ENSG00000132434" "LANCL2" "B2R8D4; hsa:55915; Q6NSL4; Q8TCQ3; Q9BSR1; Q9NS86" "" "" "0" "0" "0.985" "1.017" "0.956" "1.003" "0.986" "0.981" "0.998" "0.981" "0.783" "2307.8" "2272.3" "2346.2" "2205.5" "2315.5" "2276.4" "2263.7" "2303.2" "2264.8" "1807.6" "" "" "" "" "" "" "" "" "" "" "2074.9" "1838.7" "2122.2" "2152.8" "1910.8" "2276.4" "1695.0" "2034.3" "2026.6" "645.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6928651678899214990" "False" "High" "IsMasterProtein" "Q86VM9" "Zinc finger CCCH domain-containing protein 18 OS=Homo sapiens OX=9606 GN=ZC3H18 PE=1 SV=2" "0.000" "False" "72.870" "24" "18" "24" "18" "953" "106.3" "8.32" "88.20" "18" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf18044" "124245" "ENSG00000158545" "ZC3H18" "hsa:124245; Q86VM9; Q96DG4; Q96MP7" "" "" "0" "0" "1.004" "0.902" "0.960" "0.938" "0.947" "1.030" "0.921" "0.871" "1.136" "1748.3" "1756.1" "1576.8" "1677.7" "1640.0" "1655.6" "1800.1" "1610.4" "1522.0" "1985.3" "" "" "" "" "" "" "" "" "" "" "1571.9" "1421.0" "1426.3" "1637.7" "1353.3" "1655.6" "1347.9" "1422.4" "1361.9" "708.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635739719901529146" "False" "High" "IsMasterProtein" "Q8TB03" "Uncharacterized protein CXorf38 OS=Homo sapiens OX=9606 GN=CXorf38 PE=1 SV=1" "0.000" "False" "72.801" "61" "17" "25" "17" "319" "36.6" "6.30" "99.13" "17" "" "" "" "Pf15112" "159013" "ENSG00000185753" "CXorf38" "B3KW28; D3DWB5; hsa:159013; Q5JPF5; Q8N941; Q8TB03" "" "" "0" "0" "1.032" "1.036" "0.988" "1.073" "1.052" "1.049" "1.033" "1.057" "0.859" "2058.5" "2124.3" "2132.1" "2034.1" "2208.7" "2164.5" "2158.6" "2126.9" "2175.2" "1767.2" "" "" "" "" "" "" "" "" "" "" "1850.8" "1718.9" "1928.5" "1985.5" "1822.7" "2164.5" "1616.3" "1878.6" "1946.3" "630.8" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6238619609280539619" "False" "High" "IsMasterProtein" "Q9NZW5" "Protein PALS2 OS=Homo sapiens OX=9606 GN=PALS2 PE=1 SV=2" "0.000" "False" "72.795" "40" "20" "27" "20" "540" "61.1" "6.18" "90.09" "20" "cell organization and biogenesis" "plasma membrane;other membranes;other cell component" "" "Pf00595, Pf00625, Pf02828, Pf07653" "51678" "ENSG00000105926" "PALS2" "A4D157; hsa:51678; Q9H0E1; Q9NZW5" "" "" "0" "0" "0.965" "0.969" "0.991" "0.979" "0.954" "0.993" "0.966" "0.973" "0.909" "2319.1" "2238.3" "2247.0" "2299.1" "2270.2" "2211.4" "2302.2" "2239.9" "2257.6" "2107.8" "" "" "" "" "" "" "" "" "" "" "2085.1" "1811.2" "2032.5" "2244.3" "1873.4" "2211.4" "1723.8" "1978.4" "2020.1" "752.4" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7578805457300167027" "False" "High" "IsMasterProtein" "Q6WKZ4" "Rab11 family-interacting protein 1 OS=Homo sapiens OX=9606 GN=RAB11FIP1 PE=1 SV=3" "0.000" "False" "72.785" "20" "20" "25" "20" "1283" "137.1" "5.43" "97.98" "20" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf09457" "80223" "ENSG00000156675" "RAB11FIP1" "hsa:80223; J3KNP0; Q307T1; Q6AZK4; Q6WKZ2; Q6WKZ4; Q6WKZ6; Q86YV4; Q8TDL1; Q9H642" "" "" "0" "0" "1.053" "1.037" "1.049" "1.117" "1.118" "1.102" "1.133" "1.092" "0.935" "1333.1" "1404.0" "1382.0" "1397.8" "1489.6" "1490.7" "1468.5" "1510.1" "1456.3" "1246.8" "" "" "" "" "" "" "" "" "" "" "1198.6" "1136.1" "1250.0" "1364.5" "1229.3" "1490.7" "1099.6" "1333.8" "1303.1" "445.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7212838211136634633" "False" "High" "IsMasterProtein" "Q9NYY8" "FAST kinase domain-containing protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD2 PE=1 SV=1" "0.000" "False" "72.759" "29" "18" "30" "18" "710" "81.4" "8.05" "105.41" "18" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "22868" "ENSG00000118246" "FASTKD2" "hsa:22868; Q9NVX6; Q9NYY8; Q9Y2H7" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.041" "0.973" "0.977" "1.025" "0.945" "1.016" "1.006" "0.988" "0.988" "2310.8" "2405.5" "2249.0" "2257.0" "2367.6" "2184.8" "2348.4" "2325.7" "2283.6" "2283.9" "" "" "" "" "" "" "" "" "" "" "2077.6" "1946.4" "2034.3" "2203.2" "1953.8" "2184.8" "1758.4" "2054.2" "2043.3" "815.3" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350486907516670884" "False" "High" "IsMasterProtein" "Q7Z5K2" "Wings apart-like protein homolog OS=Homo sapiens OX=9606 GN=WAPL PE=1 SV=1" "0.000" "False" "72.704" "20" "18" "21" "17" "1190" "132.9" "5.44" "79.22" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07814" "23063" "ENSG00000062650" "WAPL" "A7E2B5; hsa:23063; Q5VSK5; Q7Z5K2; Q8IX10; Q92549" "Cohesin complex - Cornelia de Lange syndrome; 10q22q23 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Establishment of Sister Chromatid Cohesion; Cohesin Loading onto Chromatin" "6" "0" "1.010" "0.905" "1.002" "1.055" "0.919" "1.081" "0.949" "0.890" "2.310" "1684.5" "1701.9" "1524.8" "1687.3" "1777.1" "1547.8" "1820.6" "1598.1" "1499.0" "3891.5" "" "" "" "" "" "" "" "" "" "" "1514.5" "1377.2" "1379.2" "1647.0" "1466.5" "1547.8" "1363.2" "1411.6" "1341.3" "1389.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6184092773991491015" "False" "High" "IsMasterProtein" "P39748" "Flap endonuclease 1 OS=Homo sapiens OX=9606 GN=FEN1 PE=1 SV=1" "0.000" "False" "72.686" "39" "12" "29" "12" "380" "42.6" "8.62" "123.83" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2237" "ENSG00000168496" "FEN1" "hsa:2237; P39748" "Base excision repair; DNA repair pathways, full network" "HDR through MMEJ (alt-NHEJ); Early Phase of HIV Life Cycle; POLB-Dependent Long Patch Base Excision Repair; PCNA-Dependent Long Patch Base Excision Repair; Removal of the Flap Intermediate; Removal of the Flap Intermediate from the C-strand" "8" "0" "0.863" "0.850" "0.974" "0.802" "0.816" "0.986" "0.749" "0.785" "2.678" "2648.7" "2285.5" "2252.6" "2578.9" "2124.6" "2162.3" "2611.5" "1983.3" "2079.8" "7093.6" "" "" "" "" "" "" "" "" "" "" "2381.5" "1849.3" "2037.5" "2517.4" "1753.3" "2162.3" "1955.4" "1751.8" "1861.0" "2532.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "217416082876923675" "False" "High" "IsMasterProtein" "O75410" "Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens OX=9606 GN=TACC1 PE=1 SV=2" "0.000" "False" "72.438" "25" "19" "22" "19" "805" "87.7" "4.88" "83.74" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05010" "6867" "ENSG00000147526" "TACC1" "B2RBD9; B4E302; D3DSX6; hsa:6867; O75410; Q6Y687; Q86YG7; Q8IUJ2; Q8IUJ3; Q8IUJ4; Q8IZG2; Q8NEY7; Q9UPP9" "" "" "0" "0" "0.961" "1.143" "0.933" "1.005" "1.162" "1.028" "0.990" "1.116" "0.896" "1653.1" "1588.3" "1888.8" "1543.1" "1662.1" "1921.3" "1699.1" "1636.2" "1844.4" "1481.9" "" "" "" "" "" "" "" "" "" "" "1486.3" "1285.2" "1708.5" "1506.2" "1371.6" "1921.3" "1272.3" "1445.2" "1650.4" "529.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-34001002036977343" "False" "High" "IsMasterProtein" "O76003" "Glutaredoxin-3 OS=Homo sapiens OX=9606 GN=GLRX3 PE=1 SV=2" "0.000" "False" "72.412" "44" "12" "31" "12" "335" "37.4" "5.39" "115.21" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00085, Pf00462" "10539" "ENSG00000108010" "GLRX3" "B3KMP7; B3KMQ5; D3DRG2; hsa:10539; O76003; Q5JV01; Q96CE0; Q9P1B0; Q9P1B1" "" "Iron uptake and transport" "1" "0" "0.965" "1.007" "0.994" "1.017" "0.953" "0.992" "1.011" "1.023" "0.931" "3776.3" "3642.5" "3803.1" "3754.6" "3840.5" "3597.2" "3744.6" "3817.9" "3863.1" "3515.5" "" "" "" "" "" "" "" "" "" "" "3395.3" "2947.3" "3440.0" "3665.0" "3169.2" "3597.2" "2803.9" "3372.2" "3456.7" "1254.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6026735558710273601" "False" "High" "IsMasterProtein" "P36507" "Dual specificity mitogen-activated protein kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP2K2 PE=1 SV=1" "0.000" "False" "72.382" "39" "18" "35" "11" "400" "44.4" "6.55" "124.78" "18" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5605" "ENSG00000126934" "MAP2K2" "hsa:5605; P36507" "IL-5 signaling pathway; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroxine (thyroid hormone) production; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Common pathways underlying drug addiction; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Bladder cancer; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; IL6 signaling pathway; Pathways affected in adenoid cystic carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Melanoma; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Host-pathogen interaction of human coronaviruses - MAPK signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; GNAQ pathways in port-wine stain; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling; Toll-like receptor signaling pathway" "Signaling by BRAF and RAF1 fusions; Uptake and function of anthrax toxins; Signal transduction by L1; RAF activation; MAPK1 (ERK2) activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; Negative feedback regulation of MAPK pathway; Signaling by MAP2K mutants" "88" "8" "1.034" "1.008" "1.120" "0.998" "1.166" "1.044" "1.028" "1.041" "0.902" "3383.2" "3496.6" "3409.2" "3789.6" "3377.4" "3944.3" "3533.1" "3476.9" "3523.1" "3052.1" "" "" "" "" "" "" "" "" "" "" "3041.8" "2829.3" "3083.7" "3699.2" "2787.1" "3944.3" "2645.5" "3071.1" "3152.4" "1089.5" "18" "18" "18" "18" "18" "18" "18" "18" "18" "18" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3174171264893505362" "False" "High" "IsMasterProtein" "Q9H2J4" "Phosducin-like protein 3 OS=Homo sapiens OX=9606 GN=PDCL3 PE=1 SV=1" "0.000" "False" "72.348" "49" "9" "26" "9" "239" "27.6" "4.84" "112.25" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02114" "79031" "ENSG00000115539" "PDCL3" "B2RA00; hsa:79031; Q53S68; Q9H2J4" "" "" "0" "0" "0.959" "0.958" "0.983" "0.989" "0.933" "1.028" "1.001" "1.008" "0.775" "2414.9" "2315.2" "2314.2" "2373.8" "2387.4" "2252.9" "2483.4" "2416.3" "2434.7" "1871.1" "" "" "" "" "" "" "" "" "" "" "2171.2" "1873.4" "2093.3" "2317.2" "1970.1" "2252.9" "1859.5" "2134.2" "2178.5" "667.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4024286234021820395" "False" "High" "IsMasterProtein" "P78406" "mRNA export factor RAE1 OS=Homo sapiens OX=9606 GN=RAE1 PE=1 SV=1" "0.000" "False" "72.327" "43" "12" "26" "12" "368" "40.9" "7.83" "112.30" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00400" "8480" "ENSG00000101146" "RAE1" "A8K882; hsa:8480; O15306; P78406; Q3SYL7; Q5TCH8; Q6V708; Q9H100; Q9NQM6" "IL-18 signaling pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; ISG15 antiviral mechanism; Transcriptional regulation by small RNAs; Regulation of HSF1-mediated heat shock response; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus" "30" "0" "1.023" "1.040" "1.072" "1.035" "1.096" "1.076" "1.020" "1.018" "0.991" "1744.6" "1785.5" "1813.7" "1870.1" "1806.6" "1911.9" "1877.2" "1779.3" "1775.4" "1728.7" "" "" "" "" "" "" "" "" "" "" "1568.6" "1444.7" "1640.6" "1825.5" "1490.8" "1911.9" "1405.6" "1571.6" "1588.6" "617.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8357658854123366068" "False" "High" "IsMasterProtein" "O00629" "Importin subunit alpha-3 OS=Homo sapiens OX=9606 GN=KPNA4 PE=1 SV=1" "0.000" "False" "72.300" "28" "10" "29" "7" "521" "57.9" "4.96" "124.66" "10" "cell-cell signaling;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3840" "ENSG00000186432" "KPNA4" "A8K4S6; D3DNM2; hsa:3840; O00190; O00629" "Leptin signaling pathway" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways" "3" "0" "0.973" "0.994" "0.992" "1.027" "0.970" "1.015" "1.001" "0.925" "1.048" "985.8" "959.3" "980.3" "978.0" "1012.2" "956.7" "1000.9" "986.7" "911.5" "1032.9" "" "" "" "" "" "" "" "" "" "" "886.3" "776.2" "886.7" "954.7" "835.3" "956.7" "749.4" "871.5" "815.6" "368.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060406091306601688" "False" "High" "IsMasterProtein" "Q8N806" "Putative E3 ubiquitin-protein ligase UBR7 OS=Homo sapiens OX=9606 GN=UBR7 PE=1 SV=2" "0.000" "False" "72.242" "39" "14" "27" "14" "425" "48.0" "4.81" "109.17" "14" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf02207" "55148" "ENSG00000012963; ENSG00000278787" "UBR7" "Q86U21; Q86UA9; Q8N806; Q96BY0; Q9NVV6" "" "" "0" "0" "0.960" "1.026" "0.943" "0.995" "1.082" "0.961" "1.024" "1.039" "0.830" "2247.3" "2157.2" "2304.9" "2119.7" "2237.0" "2432.1" "2160.6" "2300.3" "2334.3" "1865.8" "" "" "" "" "" "" "" "" "" "" "2020.5" "1745.5" "2084.8" "2069.1" "1846.0" "2432.1" "1617.8" "2031.8" "2088.8" "666.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9193943049168300683" "False" "High" "IsMasterProtein" "Q02818" "Nucleobindin-1 OS=Homo sapiens OX=9606 GN=NUCB1 PE=1 SV=4" "0.000" "False" "72.042" "43" "17" "24" "17" "461" "53.8" "5.25" "91.78" "17" "signal transduction" "ER/Golgi" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "" "4924" "ENSG00000104805" "NUCB1" "B2RD64; hsa:4924; Q02818; Q15838; Q7Z4J7; Q9BUR1" "" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "2" "0" "0.952" "1.093" "0.969" "1.000" "1.060" "1.027" "1.018" "1.084" "0.744" "1255.4" "1195.4" "1371.6" "1216.9" "1255.3" "1331.1" "1289.8" "1277.6" "1360.6" "933.7" "" "" "" "" "" "" "" "" "" "" "1128.7" "967.3" "1240.6" "1187.9" "1035.9" "1331.1" "965.7" "1128.4" "1217.5" "333.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235259727744776076" "False" "High" "IsMasterProtein" "Q7Z4W1" "L-xylulose reductase OS=Homo sapiens OX=9606 GN=DCXR PE=1 SV=2" "0.000" "False" "71.901" "61" "11" "31" "11" "244" "25.9" "8.10" "113.14" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13561" "51181" "ENSG00000169738" "DCXR" "hsa:51181; Q7Z4W1; Q9BTZ3; Q9UHY9" "" "Formation of xylulose-5-phosphate; Essential pentosuria" "2" "0" "1.014" "1.056" "0.944" "1.023" "1.019" "1.007" "0.963" "1.036" "0.791" "2276.6" "2307.6" "2404.1" "2149.0" "2329.2" "2320.3" "2291.9" "2192.2" "2359.3" "1800.5" "" "" "" "" "" "" "" "" "" "" "2046.9" "1867.2" "2174.6" "2097.8" "1922.1" "2320.3" "1716.1" "1936.3" "2111.1" "642.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236542177406705002" "False" "High" "IsMasterProtein" "P52597" "Heterogeneous nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=HNRNPF PE=1 SV=3" "0.000" "False" "71.898" "37" "11" "42" "9" "415" "45.6" "5.58" "171.14" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf08080" "3185" "ENSG00000169813" "HNRNPF" "B3KM84; hsa:3185; P52597; Q5T0N2; Q96AU2" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "5" "0" "0.996" "0.960" "1.007" "1.014" "0.927" "1.051" "0.975" "0.930" "1.569" "2172.5" "2163.8" "2085.8" "2188.5" "2204.0" "2013.3" "2284.4" "2118.9" "2021.4" "3407.7" "" "" "" "" "" "" "" "" "" "" "1953.3" "1750.9" "1886.6" "2136.2" "1818.8" "2013.3" "1710.5" "1871.6" "1808.8" "1216.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3945672141617060885" "False" "High" "IsMasterProtein" "Q9P2E9" "Ribosome-binding protein 1 OS=Homo sapiens OX=9606 GN=RRBP1 PE=1 SV=5" "0.000" "False" "71.892" "16" "20" "26" "19" "1410" "152.4" "8.60" "88.92" "20" "protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi;translational apparatus" "other molecular function" "Pf05104" "6238" "ENSG00000125844" "RRBP1" "A0A0A0MRV0; A2A2S6; A6NCN6; hsa:6238; O75300; O75301; Q5W165; Q96SB2; Q9BWP1; Q9H476; Q9P2E9" "Ectoderm differentiation" "Signaling by ALK fusions and activated point mutants" "2" "1" "0.995" "1.019" "1.012" "1.062" "1.034" "1.160" "1.048" "0.980" "0.872" "1803.9" "1795.3" "1838.8" "1826.4" "1916.5" "1865.8" "2091.9" "1889.8" "1767.0" "1573.4" "" "" "" "" "" "" "" "" "" "" "1621.9" "1452.7" "1663.2" "1782.8" "1581.5" "1865.8" "1566.4" "1669.2" "1581.1" "561.7" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-199396300438152648" "False" "High" "IsMasterProtein" "P25788" "Proteasome subunit alpha type-3 OS=Homo sapiens OX=9606 GN=PSMA3 PE=1 SV=2" "0.000" "False" "71.710" "44" "13" "41" "13" "255" "28.4" "5.33" "141.53" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf10584" "5684" "ENSG00000100567" "PSMA3" "B2RCK6; hsa:5684; P25788; Q86U83; Q8N1D8; Q9BS70" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; Regulation of RUNX3 expression and activity; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC); Somitogenesis" "62" "0" "0.970" "0.976" "1.053" "0.950" "0.919" "0.995" "0.978" "0.974" "0.800" "4879.1" "4730.7" "4761.7" "5137.5" "4634.6" "4484.8" "4853.6" "4773.9" "4752.0" "3902.5" "" "" "" "" "" "" "" "" "" "" "4386.8" "3827.9" "4307.1" "5014.9" "3824.6" "4484.8" "3634.3" "4216.6" "4252.1" "1393.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2438255133986472284" "False" "High" "IsMasterProtein" "Q9H8H0" "Nucleolar protein 11 OS=Homo sapiens OX=9606 GN=NOL11 PE=1 SV=1" "0.000" "False" "71.702" "25" "18" "25" "18" "719" "81.1" "6.07" "85.35" "18" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf08168, Pf20998" "25926" "ENSG00000130935" "NOL11" "B7Z5V9; hsa:25926; Q7L5S1; Q9H8H0; Q9UG18" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.108" "1.304" "0.957" "1.130" "1.358" "0.980" "1.097" "1.372" "0.619" "2028.5" "2247.0" "2645.9" "1942.0" "2292.1" "2753.8" "1988.0" "2226.1" "2783.0" "1255.3" "" "" "" "" "" "" "" "" "" "" "1823.8" "1818.2" "2393.3" "1895.6" "1891.5" "2753.8" "1488.6" "1966.2" "2490.2" "448.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813014236257881133" "False" "High" "IsMasterProtein" "P21291" "Cysteine and glycine-rich protein 1 OS=Homo sapiens OX=9606 GN=CSRP1 PE=1 SV=3" "0.000" "False" "71.699" "67" "11" "45" "11" "193" "20.6" "8.57" "166.15" "11" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412" "1465" "ENSG00000159176" "CSRP1" "A8K268; hsa:1465; P21291; Q5U0J2" "MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling" "MTF1 activates gene expression" "3" "0" "0.905" "0.937" "0.943" "0.902" "0.931" "0.883" "0.953" "0.926" "0.720" "5201.1" "4705.1" "4875.1" "4903.2" "4690.6" "4843.9" "4593.3" "4954.5" "4818.3" "3744.8" "" "" "" "" "" "" "" "" "" "" "4676.3" "3807.2" "4409.7" "4786.2" "3870.8" "4843.9" "3439.4" "4376.1" "4311.4" "1336.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2160621710341352314" "False" "High" "IsMasterProtein" "O14964" "Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Homo sapiens OX=9606 GN=HGS PE=1 SV=1" "0.000" "False" "71.623" "24" "18" "28" "18" "777" "86.1" "6.16" "109.23" "18" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf01363, Pf12210" "9146" "ENSG00000185359" "HGS" "hsa:9146; O14964; Q9NR36" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Endosomal Sorting Complex Required For Transport (ESCRT); Ub-specific processing proteases; RHOU GTPase cycle; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Inhibition of membrane repair; Prevention of phagosomal-lysosomal fusion; RHOBTB3 ATPase cycle" "16" "0" "0.955" "1.002" "0.996" "0.998" "1.004" "0.969" "1.016" "0.998" "0.899" "3207.7" "3064.8" "3214.3" "3193.5" "3200.0" "3221.7" "3107.5" "3258.9" "3202.8" "2884.0" "" "" "" "" "" "" "" "" "" "" "2884.0" "2480.0" "2907.5" "3117.3" "2640.7" "3221.7" "2326.8" "2878.5" "2865.8" "1029.5" "17" "17" "17" "17" "17" "17" "17" "17" "17" "17" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1107540500627023376" "False" "High" "IsMasterProtein" "Q96EE3" "Nucleoporin SEH1 OS=Homo sapiens OX=9606 GN=SEH1L PE=1 SV=3" "0.000" "False" "71.602" "48" "13" "21" "13" "360" "39.6" "8.09" "86.94" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "81929" "ENSG00000085415" "SEH1L" "A8K5B1; hsa:81929; Q8NFU6; Q96EE3; Q96MH3; Q9C069" "" "Amino acids regulate mTORC1" "1" "0" "1.052" "1.012" "0.941" "1.059" "0.984" "1.038" "0.935" "1.050" "0.906" "1741.6" "1832.2" "1762.1" "1639.1" "1843.8" "1714.5" "1807.3" "1628.0" "1828.2" "1578.5" "" "" "" "" "" "" "" "" "" "" "1565.8" "1482.5" "1593.9" "1600.0" "1521.6" "1714.5" "1353.3" "1437.9" "1635.9" "563.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8547587141624532923" "False" "High" "IsMasterProtein" "Q9UKV8" "Protein argonaute-2 OS=Homo sapiens OX=9606 GN=AGO2 PE=1 SV=3" "0.000" "False" "71.582" "26" "20" "23" "14" "859" "97.1" "9.19" "83.51" "20" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "27161" "ENSG00000123908" "AGO2" "Q8TCZ5; Q8WV58; Q96ID1; Q9UKV8" "exRNA mechanism of action and biogenesis; Fragile X syndrome; Male infertility; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "MAPK6/MAPK4 signaling; Transcriptional regulation by small RNAs; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; M-decay: degradation of maternal mRNAs by maternally stored factors; TP53 Regulates Metabolic Genes; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "24" "3" "1.073" "0.965" "1.026" "1.091" "1.032" "1.050" "0.988" "0.979" "0.890" "1470.9" "1577.8" "1419.1" "1509.0" "1605.3" "1518.2" "1544.2" "1453.1" "1439.5" "1308.7" "" "" "" "" "" "" "" "" "" "" "1322.4" "1276.7" "1283.7" "1472.9" "1324.7" "1518.2" "1156.3" "1283.5" "1288.1" "467.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5375173174660804131" "False" "High" "IsMasterProtein" "Q16698" "2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial OS=Homo sapiens OX=9606 GN=DECR1 PE=1 SV=1" "0.000" "False" "71.484" "45" "12" "24" "12" "335" "36.0" "9.28" "94.12" "12" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf13561" "1666" "ENSG00000104325" "DECR1" "B7Z6B8; hsa:1666; Q16698; Q2M304; Q93085" "Fatty acid beta-oxidation; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Omega-6-fatty acids in senescence" "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "1.049" "1.046" "0.966" "1.044" "1.026" "0.984" "1.045" "1.028" "0.769" "1974.4" "2071.9" "2064.6" "1907.8" "2060.3" "2025.1" "1942.8" "2063.6" "2030.5" "1518.7" "" "" "" "" "" "" "" "" "" "" "1775.2" "1676.5" "1867.5" "1862.2" "1700.2" "2025.1" "1454.7" "1822.7" "1816.9" "542.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260610778738387308" "False" "High" "IsMasterProtein" "Q13907" "Isopentenyl-diphosphate Delta-isomerase 1 OS=Homo sapiens OX=9606 GN=IDI1 PE=1 SV=2" "0.000" "False" "71.442" "50" "11" "30" "11" "227" "26.3" "6.34" "117.27" "11" "other metabolic processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00293" "3422" "ENSG00000067064" "IDI1" "B4E155; hsa:3422; Q13907; Q32Q13; Q53GQ6; Q86U81; Q8WUX8; Q96IZ4; Q9BQ74" "Target of rapamycin signaling; Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Exercise-induced circadian regulation; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "11" "0" "1.012" "1.102" "1.077" "1.072" "1.163" "1.033" "1.054" "1.140" "0.868" "2438.1" "2467.0" "2687.2" "2625.5" "2614.2" "2835.2" "2519.1" "2569.3" "2778.5" "2117.4" "" "" "" "" "" "" "" "" "" "" "2192.1" "1996.2" "2430.6" "2562.9" "2157.3" "2835.2" "1886.2" "2269.3" "2486.2" "755.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4709536422529614216" "False" "High" "IsMasterProtein" "P20618" "Proteasome subunit beta type-1 OS=Homo sapiens OX=9606 GN=PSMB1 PE=1 SV=2" "0.000" "False" "71.426" "54" "13" "33" "13" "241" "26.5" "8.13" "127.69" "13" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf00227" "5689" "ENSG00000008018" "PSMB1" "B5BU76; hsa:5689; P20618; Q9BWA8" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neutrophil degranulation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; FCERI mediated NF-kB activation; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.998" "0.972" "1.031" "1.023" "0.954" "0.973" "1.006" "1.016" "0.879" "2170.3" "2167.0" "2110.6" "2238.2" "2221.2" "2071.5" "2110.8" "2183.2" "2204.4" "1906.8" "" "" "" "" "" "" "" "" "" "" "1951.3" "1753.5" "1909.1" "2184.8" "1833.0" "2071.5" "1580.5" "1928.4" "1972.5" "680.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4926655616225133563" "False" "High" "IsMasterProtein" "Q86TI0" "TBC1 domain family member 1 OS=Homo sapiens OX=9606 GN=TBC1D1 PE=1 SV=2" "0.000" "False" "71.410" "21" "22" "26" "20" "1168" "133.0" "6.96" "89.18" "22" "" "nucleus" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "23216" "ENSG00000065882" "TBC1D1" "B7Z3D9; E9PGH8; hsa:23216; Q86TI0; Q96K82; Q9UPP4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "2" "0" "1.064" "0.961" "1.000" "1.029" "0.970" "1.059" "1.044" "0.991" "1.102" "1034.3" "1100.7" "993.5" "1034.0" "1064.6" "1003.5" "1095.4" "1079.4" "1024.9" "1139.9" "" "" "" "" "" "" "" "" "" "" "930.0" "890.6" "898.7" "1009.3" "878.5" "1003.5" "820.2" "953.4" "917.1" "406.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5921429182500705176" "False" "High" "IsMasterProtein" "O43765" "Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens OX=9606 GN=SGTA PE=1 SV=1" "0.000" "False" "71.344" "39" "11" "38" "11" "313" "34.0" "4.87" "129.76" "11" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00515, Pf13181, Pf16546" "6449" "ENSG00000104969" "SGTA" "D6W610; hsa:6449; O43765; Q6FIA9; Q9BTZ9" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "0.884" "0.924" "0.930" "0.934" "0.896" "0.935" "0.967" "0.953" "0.818" "3966.3" "3506.6" "3663.6" "3689.5" "3705.1" "3555.1" "3708.3" "3835.7" "3778.2" "3243.6" "" "" "" "" "" "" "" "" "" "" "3566.1" "2837.4" "3313.9" "3601.5" "3057.5" "3555.1" "2776.7" "3387.9" "3380.7" "1157.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3977231737757699064" "False" "High" "IsMasterProtein" "Q6JBY9" "CapZ-interacting protein OS=Homo sapiens OX=9606 GN=RCSD1 PE=1 SV=1" "0.000" "False" "71.056" "55" "17" "25" "17" "416" "44.5" "5.40" "115.41" "17" "stress response;transport;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05177, Pf15255" "92241" "ENSG00000198771" "RCSD1" "B1AK48; hsa:92241; Q4G0E7; Q6IN93; Q6JBY9; Q8IZM2; Q96DX0; Q9NST4" "" "" "0" "0" "0.940" "0.922" "0.981" "0.989" "0.977" "0.958" "1.048" "0.931" "0.746" "2730.2" "2565.9" "2517.9" "2677.3" "2698.9" "2667.4" "2615.8" "2860.8" "2542.5" "2037.3" "" "" "" "" "" "" "" "" "" "" "2454.7" "2076.3" "2277.5" "2613.5" "2227.1" "2667.4" "1958.7" "2526.8" "2275.0" "727.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7181464862980127615" "False" "High" "IsMasterProtein" "Q13630" "GDP-L-fucose synthase OS=Homo sapiens OX=9606 GN=GFUS PE=1 SV=1" "0.000" "False" "71.042" "50" "11" "23" "11" "321" "35.9" "6.60" "99.89" "11" "cell adhesion;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01370" "7264" "ENSG00000104522; ENSG00000278243" "GFUS" "B2R8Y7; D3DWK5; hsa:7264; Q13630; Q567Q9; Q9UDG7" "" "GDP-fucose biosynthesis" "1" "0" "1.048" "1.031" "0.992" "1.051" "0.985" "1.008" "1.009" "1.047" "0.831" "1705.3" "1787.4" "1758.1" "1692.1" "1792.5" "1679.4" "1719.6" "1720.8" "1785.3" "1416.8" "" "" "" "" "" "" "" "" "" "" "1533.2" "1446.3" "1590.3" "1651.7" "1479.2" "1679.4" "1287.6" "1519.9" "1597.5" "505.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6144698658960758490" "False" "High" "IsMasterProtein" "Q8IXB1" "DnaJ homolog subfamily C member 10 OS=Homo sapiens OX=9606 GN=DNAJC10 PE=1 SV=2" "0.000" "False" "70.972" "21" "15" "27" "15" "793" "91.0" "7.18" "92.45" "15" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi" "other molecular function" "Pf00085, Pf00226" "54431" "ENSG00000077232" "DNAJC10" "hsa:54431; Q17RJ6; Q3B7W8; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8IXB1; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6" "" "" "0" "0" "0.997" "1.048" "0.952" "0.985" "1.039" "1.006" "1.013" "1.034" "0.909" "2087.3" "2081.1" "2187.4" "1986.8" "2056.1" "2168.9" "2099.5" "2114.1" "2158.8" "1897.7" "" "" "" "" "" "" "" "" "" "" "1876.7" "1683.9" "1978.5" "1939.4" "1696.7" "2168.9" "1572.1" "1867.3" "1931.7" "677.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4258123771778816743" "False" "High" "IsMasterProtein" "P55265" "Double-stranded RNA-specific adenosine deaminase OS=Homo sapiens OX=9606 GN=ADAR PE=1 SV=4" "0.000" "False" "70.956" "15" "17" "25" "17" "1226" "136.0" "8.65" "83.24" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf02137, Pf02295" "103" "ENSG00000160710" "ADAR" "B1AQQ9; B1AQR0; D3DV76; hsa:103; O15223; O43859; O43860; P55265; Q9BYM3; Q9BYM4" "Measles virus infection; Cytosolic DNA-sensing pathway" "PKR-mediated signaling; Interferon alpha/beta signaling; C6 deamination of adenosine; Formation of editosomes by ADAR proteins" "6" "0" "1.010" "0.995" "1.010" "0.993" "1.019" "1.045" "0.880" "0.890" "1.899" "1012.5" "1022.6" "1007.5" "1023.0" "1005.2" "1032.2" "1058.4" "891.3" "900.8" "1923.0" "" "" "" "" "" "" "" "" "" "" "910.4" "827.5" "911.4" "998.6" "829.5" "1032.2" "792.5" "787.3" "806.0" "686.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-65550439794871329" "False" "High" "IsMasterProtein" "Q9BXS5" "AP-1 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP1M1 PE=1 SV=3" "0.000" "False" "70.931" "49" "17" "29" "17" "423" "48.6" "7.30" "97.91" "17" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "8907" "ENSG00000072958" "AP1M1" "hsa:8907; Q4TTY5; Q9BXS5" "" "Neutrophil degranulation; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "5" "0" "1.051" "1.041" "0.992" "1.035" "0.977" "1.040" "0.979" "1.050" "1.199" "2537.5" "2666.4" "2642.3" "2518.0" "2625.9" "2479.1" "2640.2" "2485.1" "2664.9" "3042.6" "" "" "" "" "" "" "" "" "" "" "2281.5" "2157.6" "2390.0" "2457.9" "2166.9" "2479.1" "1976.9" "2195.0" "2384.6" "1086.1" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636260914267966179" "False" "High" "IsMasterProtein" "Q6YP21" "Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens OX=9606 GN=KYAT3 PE=1 SV=1" "0.000" "False" "70.865" "43" "16" "29" "15" "454" "51.4" "8.19" "110.75" "16" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00155" "56267" "ENSG00000137944" "KYAT3" "B3KQ13; hsa:56267; O95335; Q5JS27; Q5T9T7; Q5T9T8; Q6AI27; Q6ICW1; Q6YP21; Q9BVY5" "Tryptophan metabolism" "Tryptophan catabolism" "2" "1" "1.025" "1.035" "1.001" "1.064" "1.011" "1.009" "1.024" "1.041" "0.933" "2673.9" "2740.5" "2768.2" "2677.7" "2844.5" "2702.7" "2696.7" "2738.2" "2783.5" "2496.0" "" "" "" "" "" "" "" "" "" "" "2404.1" "2217.5" "2503.9" "2613.8" "2347.4" "2702.7" "2019.2" "2418.5" "2490.7" "891.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446725702153589765" "False" "High" "IsMasterProtein" "Q9Y2T2" "AP-3 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP3M1 PE=1 SV=1" "0.000" "False" "70.851" "44" "14" "24" "11" "418" "46.9" "6.93" "94.71" "14" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00928, Pf01217" "26985" "ENSG00000185009" "AP3M1" "hsa:26985; Q5JQ12; Q9H5L2; Q9Y2T2" "" "Association of TriC/CCT with target proteins during biosynthesis" "1" "2" "1.037" "1.008" "1.006" "0.998" "0.951" "1.022" "1.011" "1.073" "1.005" "1843.5" "1911.1" "1857.8" "1853.7" "1840.2" "1753.6" "1884.8" "1864.6" "1978.9" "1853.6" "" "" "" "" "" "" "" "" "" "" "1657.5" "1546.4" "1680.4" "1809.5" "1518.6" "1753.6" "1411.3" "1647.0" "1770.7" "661.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2454508349601298395" "False" "High" "IsMasterProtein" "Q99447" "Ethanolamine-phosphate cytidylyltransferase OS=Homo sapiens OX=9606 GN=PCYT2 PE=1 SV=1" "0.000" "False" "70.802" "47" "17" "25" "17" "389" "43.8" "6.92" "92.18" "17" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01467" "5833" "ENSG00000185813" "PCYT2" "B7Z7A5; B7ZAS0; F5H8B1; hsa:5833; Q6IBM3; Q96G08; Q99447" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "1.005" "1.031" "0.932" "1.007" "0.955" "0.967" "0.971" "1.014" "0.842" "1873.7" "1883.5" "1930.9" "1747.0" "1887.3" "1789.2" "1812.1" "1820.2" "1900.8" "1578.5" "" "" "" "" "" "" "" "" "" "" "1684.6" "1524.1" "1746.6" "1705.3" "1557.4" "1789.2" "1356.9" "1607.7" "1700.8" "563.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3200179838073860903" "False" "High" "IsMasterProtein" "O76031" "ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Homo sapiens OX=9606 GN=CLPX PE=1 SV=2" "0.000" "False" "70.800" "26" "15" "21" "15" "633" "69.2" "7.58" "80.74" "15" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07724, Pf10431" "10845" "ENSG00000166855" "CLPX" "A1L428; A8K8F1; B9EGI8; hsa:10845; O76031; Q9H4D9" "" "Mitochondrial protein degradation" "1" "0" "0.965" "0.902" "0.935" "0.955" "0.985" "0.950" "1.032" "1.085" "0.940" "1989.5" "1920.2" "1794.3" "1861.0" "1900.5" "1959.4" "1890.9" "2053.3" "2158.9" "1870.0" "" "" "" "" "" "" "" "" "" "" "1788.8" "1553.8" "1623.0" "1816.6" "1568.4" "1959.4" "1415.9" "1813.6" "1931.8" "667.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1997849162023251854" "False" "High" "IsMasterProtein" "P63208" "S-phase kinase-associated protein 1 OS=Homo sapiens OX=9606 GN=SKP1 PE=1 SV=2" "0.000" "False" "70.466" "71" "10" "40" "10" "163" "18.6" "4.54" "148.54" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01466, Pf03931" "6500" "ENSG00000113558" "SKP1" "D3DQ97; D3DQ98; hsa:6500; P34991; P63208; Q8TAY2" "Cell cycle; TNF-alpha signaling pathway; TGF-beta signaling pathway; Breast cancer pathway; Small cell lung cancer; Notch signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; Vpu mediated degradation of CD4; Degradation of beta-catenin by the destruction complex; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; NIK-->noncanonical NF-kB signaling; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; SCF(Skp2)-mediated degradation of p27/p21; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; Circadian Clock; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Cyclin D associated events in G1; Regulation of BACH1 activity; MAP3K8 (TPL2)-dependent MAPK1/3 activation; NOTCH1 Intracellular Domain Regulates Transcription; Prolactin receptor signaling; Iron uptake and transport; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "39" "0" "0.974" "1.065" "0.905" "1.045" "1.179" "1.002" "1.071" "1.113" "0.794" "2774.8" "2702.4" "2954.7" "2510.2" "2898.8" "3271.9" "2781.5" "2971.0" "3087.3" "2202.4" "" "" "" "" "" "" "" "" "" "" "2494.8" "2186.7" "2672.6" "2450.3" "2392.1" "3271.9" "2082.7" "2624.2" "2762.5" "786.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802670806529502835" "False" "High" "IsMasterProtein" "Q6NYC8" "Phostensin OS=Homo sapiens OX=9606 GN=PPP1R18 PE=1 SV=1" "0.000" "False" "70.398" "30" "15" "23" "15" "613" "67.9" "5.40" "99.66" "15" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf13914, Pf13916" "170954" "ENSG00000146112; ENSG00000206485; ENSG00000225060; ENSG00000229998; ENSG00000230341; ENSG00000234000" "PPP1R18" "A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; hsa:170954; Q68CK8; Q6NYC8; Q6ZTV1; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9" "TYROBP causal network in microglia" "" "1" "0" "0.998" "1.033" "1.010" "1.073" "1.120" "1.070" "1.086" "1.066" "0.922" "1192.8" "1190.1" "1231.8" "1204.5" "1280.1" "1335.4" "1276.9" "1295.4" "1271.4" "1100.2" "" "" "" "" "" "" "" "" "" "" "1072.5" "963.0" "1114.2" "1175.8" "1056.4" "1335.4" "956.1" "1144.2" "1137.6" "392.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6767865713948388298" "False" "High" "IsMasterProtein" "P49720" "Proteasome subunit beta type-3 OS=Homo sapiens OX=9606 GN=PSMB3 PE=1 SV=2" "0.000" "False" "70.308" "43" "9" "36" "9" "205" "22.9" "6.55" "147.03" "9" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5691" "ENSG00000275903; ENSG00000277791" "PSMB3" "hsa:5691; P31147; P49720; Q0P6J7; Q96E27" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.058" "1.052" "1.039" "1.026" "0.986" "1.056" "1.002" "1.065" "0.857" "3750.3" "3967.7" "3945.6" "3897.9" "3849.0" "3699.5" "3958.9" "3757.9" "3995.4" "3212.9" "" "" "" "" "" "" "" "" "" "" "3371.8" "3210.5" "3568.9" "3804.9" "3176.3" "3699.5" "2964.3" "3319.2" "3575.0" "1146.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5829960447854698720" "False" "High" "IsMasterProtein" "O43399" "Tumor protein D54 OS=Homo sapiens OX=9606 GN=TPD52L2 PE=1 SV=2" "0.000" "False" "70.223" "58" "12" "27" "12" "206" "22.2" "5.36" "115.08" "12" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf04201" "7165" "ENSG00000101150" "TPD52L2" "B4DPJ6; E1P5G7; hsa:7165; O43398; O43399; Q5JWU5; Q5JWU6; Q5JWU8; Q5U0E0; Q9H3Z6" "" "" "0" "0" "0.890" "0.906" "0.959" "0.904" "0.935" "0.972" "0.994" "0.966" "0.800" "3784.8" "3367.3" "3430.6" "3627.9" "3422.9" "3540.6" "3679.2" "3760.9" "3655.5" "3027.5" "" "" "" "" "" "" "" "" "" "" "3402.9" "2724.7" "3103.1" "3541.3" "2824.6" "3540.6" "2754.9" "3321.9" "3270.9" "1080.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3545967028758689053" "False" "High" "IsMasterProtein" "P36543" "V-type proton ATPase subunit E 1 OS=Homo sapiens OX=9606 GN=ATP6V1E1 PE=1 SV=1" "0.000" "False" "70.114" "41" "11" "43" "11" "226" "26.1" "8.00" "143.95" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01991" "529" "ENSG00000131100" "ATP6V1E1" "A8MUE4; A8MUN4; hsa:529; P36543" "VEGFA-VEGFR2 signaling; Proximal tubule transport" "Insulin receptor recycling; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.025" "1.011" "0.993" "1.015" "0.994" "1.055" "1.060" "1.013" "0.884" "3536.4" "3626.5" "3576.1" "3512.4" "3590.5" "3514.6" "3730.8" "3748.0" "3580.7" "3125.4" "" "" "" "" "" "" "" "" "" "" "3179.6" "2934.4" "3234.7" "3428.6" "2962.9" "3514.6" "2793.5" "3310.5" "3204.0" "1115.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049594169438393906" "False" "High" "IsMasterProtein" "Q52LJ0" "Protein FAM98B OS=Homo sapiens OX=9606 GN=FAM98B PE=1 SV=2" "0.000" "False" "70.107" "41" "12" "27" "9" "433" "45.5" "8.69" "105.05" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "283742" "ENSG00000171262" "FAM98B" "A8MUW5; hsa:283742; Q52LJ0; Q8N935" "" "tRNA processing in the nucleus" "1" "3" "1.008" "1.027" "1.012" "1.076" "1.059" "1.054" "1.040" "1.043" "1.080" "1326.5" "1336.8" "1362.0" "1342.4" "1427.1" "1405.1" "1398.2" "1379.9" "1383.1" "1432.0" "" "" "" "" "" "" "" "" "" "" "1192.7" "1081.7" "1232.0" "1310.4" "1177.7" "1405.1" "1046.9" "1218.8" "1237.6" "511.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-824304309308168891" "False" "High" "IsMasterProtein" "Q14005" "Pro-interleukin-16 OS=Homo sapiens OX=9606 GN=IL16 PE=1 SV=4" "0.000" "False" "70.008" "17" "17" "28" "17" "1332" "141.7" "8.06" "94.87" "17" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00595" "3603" "ENSG00000172349" "IL16" "A6NM20; A8MU65; B5TY35; B9EGR6; H3BVH5; hsa:3603; Q14005; Q16435; Q6VVE6; Q6ZMQ7; Q9UP18" "" "Other interleukin signaling" "1" "0" "0.958" "0.962" "0.937" "0.971" "0.909" "0.973" "0.984" "0.945" "0.842" "1683.4" "1613.1" "1619.7" "1576.8" "1634.1" "1531.1" "1638.4" "1657.3" "1591.3" "1417.7" "" "" "" "" "" "" "" "" "" "" "1513.6" "1305.2" "1465.0" "1539.2" "1348.5" "1531.1" "1226.8" "1463.8" "1423.9" "506.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9221367924290970171" "False" "High" "IsMasterProtein" "Q07812" "Apoptosis regulator BAX OS=Homo sapiens OX=9606 GN=BAX PE=1 SV=1" "0.000" "False" "69.939" "44" "6" "26" "6" "192" "21.2" "5.22" "95.83" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "581" "ENSG00000087088" "BAX" "A8K4W1; hsa:581; P55269; Q07812; Q07814; Q07815; Q8WZ49; Q9NR76; Q9NYG7; Q9UCZ6; Q9UCZ7; Q9UQD6" "miRNA regulation of DNA damage response; TP53 network; Leptin signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Mammary gland development pathway - Involution (Stage 4 of 4); Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Overview of nanoparticle effects; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; p53 transcriptional gene network; Pleural mesothelioma; Complement system in neuronal development and plasticity; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; IL-26 signaling pathways; HDAC6 interactions in the central nervous system; DNA damage response; DNA damage response (only ATM dependent)" "TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Transcriptional regulation by RUNX2; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; Release of apoptotic factors from the mitochondria; Pyroptosis; Activation, translocation and oligomerization of BAX; NTRK3 as a dependence receptor" "48" "0" "1.010" "0.980" "1.002" "1.026" "0.956" "0.977" "1.002" "0.975" "0.832" "2496.9" "2521.4" "2446.7" "2502.2" "2562.9" "2387.0" "2440.3" "2501.1" "2433.6" "2076.2" "" "" "" "" "" "" "" "" "" "" "2244.9" "2040.3" "2213.2" "2442.5" "2115.0" "2387.0" "1827.3" "2209.2" "2177.5" "741.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2471884395781023228" "False" "High" "IsMasterProtein" "Q9Y5X2" "Sorting nexin-8 OS=Homo sapiens OX=9606 GN=SNX8 PE=1 SV=1" "0.000" "False" "69.828" "31" "12" "22" "12" "465" "52.5" "7.39" "84.59" "12" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf19566" "29886" "ENSG00000106266" "SNX8" "A4D207; hsa:29886; Q96I67; Q9Y5X2" "" "" "0" "0" "1.036" "1.086" "0.976" "1.031" "1.065" "1.045" "1.042" "1.045" "0.806" "1296.7" "1342.8" "1408.5" "1266.1" "1336.8" "1381.5" "1354.6" "1350.5" "1354.7" "1045.7" "" "" "" "" "" "" "" "" "" "" "1165.8" "1086.5" "1274.0" "1235.9" "1103.2" "1381.5" "1014.3" "1192.8" "1212.2" "373.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607274144029287900" "False" "High" "IsMasterProtein" "O14929" "Histone acetyltransferase type B catalytic subunit OS=Homo sapiens OX=9606 GN=HAT1 PE=1 SV=2" "0.000" "False" "69.800" "34" "9" "30" "9" "419" "49.5" "5.69" "114.62" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10394, Pf21183" "8520" "ENSG00000128708" "HAT1" "hsa:8520; O14929; Q49A44; Q53QF0; Q53SU4; Q6P594; Q8WWB9" "Ethanol effects on histone modifications" "HATs acetylate histones" "2" "0" "1.034" "1.086" "0.961" "1.048" "1.031" "1.018" "1.020" "1.071" "0.923" "2967.9" "3070.1" "3223.5" "2851.8" "3111.1" "3060.7" "3020.0" "3028.4" "3178.9" "2740.7" "" "" "" "" "" "" "" "" "" "" "2668.4" "2484.2" "2915.7" "2783.7" "2567.4" "3060.7" "2261.3" "2674.8" "2844.4" "978.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7212172965787635527" "False" "High" "IsMasterProtein" "Q15031" "Leucine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=LARS2 PE=1 SV=2" "0.000" "False" "69.786" "19" "17" "24" "17" "903" "101.9" "8.22" "85.39" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00133, Pf08264, Pf13603" "23395" "ENSG00000011376" "LARS2" "hsa:23395; Q15031" "Amino acid metabolism; IL-18 signaling pathway; Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "4" "0" "1.061" "1.055" "1.001" "1.115" "1.051" "1.072" "1.086" "1.073" "0.909" "2635.8" "2797.3" "2779.9" "2637.3" "2940.1" "2769.0" "2825.3" "2863.0" "2827.9" "2395.6" "" "" "" "" "" "" "" "" "" "" "2369.8" "2263.5" "2514.5" "2574.3" "2426.2" "2769.0" "2115.5" "2528.8" "2530.4" "855.2" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120451514636770754" "False" "High" "IsMasterProtein" "Q12979" "Active breakpoint cluster region-related protein OS=Homo sapiens OX=9606 GN=ABR PE=1 SV=2" "0.000" "False" "69.665" "25" "20" "26" "18" "859" "97.5" "6.55" "90.88" "20" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00168, Pf00620, Pf00621" "29" "ENSG00000159842; ENSG00000276016; ENSG00000278741" "ABR" "B3KW89; B7Z6H7; D3DTH3; D3DTH4; F5H3S2; F5H8B3; hsa:29; Q12979; Q13693; Q13694" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC3 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOC GTPase cycle; RAC2 GTPase cycle; RHOB GTPase cycle" "9" "2" "1.075" "0.986" "0.971" "1.037" "0.965" "1.011" "0.980" "0.980" "1.691" "1873.4" "2013.0" "1846.4" "1819.4" "1943.2" "1806.9" "1893.6" "1835.7" "1835.2" "3167.0" "" "" "" "" "" "" "" "" "" "" "1684.4" "1628.9" "1670.2" "1776.0" "1603.6" "1806.9" "1417.9" "1621.4" "1642.1" "1130.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1726456948051343577" "False" "High" "IsMasterProtein" "Q96G46" "tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS3L PE=1 SV=2" "0.000" "False" "69.605" "33" "17" "22" "17" "650" "72.5" "8.05" "83.73" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "" "other molecular function" "Pf01207" "56931" "ENSG00000141994" "DUS3L" "hsa:56931; Q96G46; Q96HM5; Q9BSU4; Q9H877; Q9NPR1" "" "" "0" "0" "1.029" "1.002" "1.044" "1.040" "1.010" "0.977" "1.055" "1.019" "0.956" "1691.8" "1741.6" "1695.3" "1766.4" "1760.2" "1708.8" "1652.4" "1784.7" "1723.1" "1616.6" "" "" "" "" "" "" "" "" "" "" "1521.0" "1409.2" "1533.5" "1724.2" "1452.5" "1708.8" "1237.3" "1576.4" "1541.8" "577.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1393255483118757770" "False" "High" "IsMasterProtein" "Q9H2U2" "Inorganic pyrophosphatase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PPA2 PE=1 SV=2" "0.000" "False" "69.556" "45" "13" "30" "12" "334" "37.9" "7.39" "118.75" "13" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00719" "27068" "ENSG00000138777" "PPA2" "B4DLP7; F8WDN9; hsa:27068; I6L9B6; Q4W5E9; Q6PG51; Q8TBW0; Q96E55; Q9H0T0; Q9H2U2; Q9NX37; Q9P033; Q9ULX0" "" "Mitochondrial tRNA aminoacylation; Pyrophosphate hydrolysis" "2" "0" "0.992" "0.984" "1.012" "1.012" "0.989" "0.993" "1.005" "0.988" "0.792" "2621.0" "2598.9" "2580.2" "2651.3" "2653.2" "2591.1" "2602.0" "2633.6" "2588.9" "2075.2" "" "" "" "" "" "" "" "" "" "" "2356.5" "2102.9" "2333.9" "2588.1" "2189.5" "2591.1" "1948.3" "2326.1" "2316.5" "740.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4462152622631022902" "False" "High" "IsMasterProtein" "Q92922" "SWI/SNF complex subunit SMARCC1 OS=Homo sapiens OX=9606 GN=SMARCC1 PE=1 SV=3" "0.000" "False" "69.249" "16" "17" "22" "12" "1105" "122.8" "5.76" "83.78" "17" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf04433, Pf16495, Pf16496, Pf16498" "6599" "ENSG00000173473" "SMARCC1" "hsa:6599; Q17RS0; Q6P172; Q8IWH2; Q92922" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "1.035" "0.916" "1.013" "1.044" "0.882" "1.106" "0.873" "0.829" "4.784" "1064.7" "1102.3" "974.8" "1078.7" "1111.5" "939.0" "1177.5" "929.7" "882.4" "5093.2" "" "" "" "" "" "" "" "" "" "" "957.3" "891.9" "881.7" "1053.0" "917.3" "939.0" "881.7" "821.2" "789.5" "1818.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6282846472165231546" "False" "High" "IsMasterProtein" "Q9P289" "Serine/threonine-protein kinase 26 OS=Homo sapiens OX=9606 GN=STK26 PE=1 SV=2" "0.000" "False" "69.245" "36" "14" "27" "7" "416" "46.5" "5.29" "96.54" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "51765" "ENSG00000134602" "STK26" "B2RAU2; hsa:51765; Q3ZB77; Q8NC04; Q9BXC3; Q9BXC4; Q9P289" "" "Apoptotic cleavage of cellular proteins" "1" "0" "0.946" "0.970" "0.908" "0.960" "0.975" "1.001" "0.962" "0.968" "1.551" "1019.5" "964.2" "989.0" "925.2" "978.7" "993.7" "1020.4" "981.2" "987.0" "1581.4" "" "" "" "" "" "" "" "" "" "" "916.6" "780.2" "894.6" "903.1" "807.7" "993.7" "764.1" "866.6" "883.1" "564.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3464311242002607672" "False" "High" "IsMasterProtein" "P86790" "Vacuolar fusion protein CCZ1 homolog B OS=Homo sapiens OX=9606 GN=CCZ1B PE=1 SV=1" "0.000" "False" "69.142" "33" "13" "22" "13" "482" "55.8" "6.48" "90.17" "13" "transport" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf19031, Pf19032, Pf19033" "221960; 51622" "ENSG00000146574" "CCZ1B" "A2RU45; hsa:221960; hsa:51622; O95766; P86790; Q9UG65; Q9Y359" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.000" "0.990" "0.986" "1.071" "0.989" "1.023" "1.018" "1.032" "1.011" "2088.2" "2087.6" "2067.7" "2058.1" "2237.3" "2065.1" "2135.7" "2126.0" "2154.0" "2112.1" "" "" "" "" "" "" "" "" "" "" "1877.5" "1689.2" "1870.3" "2009.0" "1846.3" "2065.1" "1599.1" "1877.8" "1927.4" "754.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8296927392794764826" "False" "High" "IsMasterProtein" "Q9BZL4" "Protein phosphatase 1 regulatory subunit 12C OS=Homo sapiens OX=9606 GN=PPP1R12C PE=1 SV=1" "0.000" "False" "69.053" "26" "15" "22" "15" "782" "84.8" "5.57" "84.24" "15" "signal transduction" "cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf12796, Pf15898" "54776" "ENSG00000125503" "PPP1R12C" "B4DME2; hsa:54776; Q59FK8; Q6ZPD1; Q7L8F7; Q96HW1; Q9BZL4; Q9H5H5; Q9NT00" "Focal adhesion" "" "1" "0" "0.978" "1.058" "0.977" "1.015" "1.076" "1.011" "1.023" "1.034" "1.124" "1342.2" "1313.2" "1420.5" "1310.8" "1362.7" "1443.9" "1357.2" "1373.4" "1387.9" "1508.4" "" "" "" "" "" "" "" "" "" "" "1206.8" "1062.6" "1284.9" "1279.6" "1124.5" "1443.9" "1016.2" "1213.0" "1241.9" "538.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8408211072324921186" "False" "High" "IsMasterProtein" "P78344" "Eukaryotic translation initiation factor 4 gamma 2 OS=Homo sapiens OX=9606 GN=EIF4G2 PE=1 SV=1" "0.000" "False" "69.025" "20" "17" "27" "17" "907" "102.3" "7.14" "78.15" "17" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "1982" "ENSG00000110321" "EIF4G2" "hsa:1982; O60877; P78344; P78404; Q0VH00; Q0VH01; Q2NKW9; Q49A79; Q53EU1; Q58EZ2; Q8NI71; Q96C16" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation; Acute viral myocarditis" "ISG15 antiviral mechanism" "4" "0" "1.003" "1.023" "0.987" "1.022" "0.982" "1.123" "0.898" "0.982" "4.113" "1830.9" "1837.1" "1872.6" "1807.0" "1871.0" "1798.3" "2056.7" "1644.2" "1797.6" "7530.7" "" "" "" "" "" "" "" "" "" "" "1646.2" "1486.5" "1693.8" "1763.9" "1544.0" "1798.3" "1540.0" "1452.3" "1608.5" "2688.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-320392191251803943" "False" "High" "IsMasterProtein" "Q9BXS6" "Nucleolar and spindle-associated protein 1 OS=Homo sapiens OX=9606 GN=NUSAP1 PE=1 SV=1" "0.000" "False" "69.004" "49" "17" "24" "17" "441" "49.4" "9.91" "96.55" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity" "Pf16006" "51203" "ENSG00000137804" "NUSAP1" "B4DDF1; E7ERR5; hsa:51203; J3KN21; Q53GW2; Q8TBT4; Q96E58; Q96FJ1; Q9BXS6; Q9GZM9; Q9NZ85; Q9UI70" "" "" "0" "0" "0.869" "0.799" "0.985" "0.853" "0.871" "0.943" "0.928" "0.798" "0.852" "1821.0" "1582.7" "1454.5" "1793.2" "1552.6" "1586.8" "1717.8" "1690.2" "1454.1" "1551.6" "" "" "" "" "" "" "" "" "" "" "1637.3" "1280.7" "1315.6" "1750.4" "1281.2" "1586.8" "1286.2" "1492.9" "1301.1" "553.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2851468461982241185" "False" "High" "IsMasterProtein" "P30626" "Sorcin OS=Homo sapiens OX=9606 GN=SRI PE=1 SV=1" "0.000" "False" "68.924" "61" "10" "43" "10" "198" "21.7" "5.59" "141.91" "10" "transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13499, Pf13833" "6717" "ENSG00000075142" "SRI" "A8MTH6; B4DKK2; D6W5Q0; hsa:6717; P30626" "" "Stimuli-sensing channels; Ion homeostasis; Ion transport by P-type ATPases; Reduction of cytosolic Ca++ levels; Sodium/Calcium exchangers" "5" "0" "0.940" "0.952" "0.951" "0.997" "0.962" "0.940" "0.970" "0.983" "0.798" "4868.6" "4575.8" "4634.5" "4629.5" "4852.4" "4684.2" "4578.2" "4721.3" "4786.4" "3886.0" "" "" "" "" "" "" "" "" "" "" "4377.4" "3702.6" "4192.0" "4519.0" "4004.3" "4684.2" "3428.0" "4170.2" "4282.9" "1387.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "197200824509217859" "False" "High" "IsMasterProtein" "P31040" "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHA PE=1 SV=2" "0.000" "False" "68.912" "34" "15" "20" "15" "664" "72.6" "7.39" "89.75" "15" "other metabolic processes;developmental processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00890, Pf02910" "6389" "ENSG00000073578" "SDHA" "A8K5J6; B4DJ60; E9PBJ5; hsa:6389; P31040; Q16395; Q59GW8; Q8IW48; Q9UMY5" "Electron transport chain: OXPHOS system in mitochondria; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc); Amino acid metabolism; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; Arsenic metabolism and reactive oxygen species generation; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "9" "0" "0.963" "1.175" "1.053" "1.053" "1.194" "1.070" "1.052" "1.248" "0.829" "822.6" "792.2" "966.2" "866.0" "866.4" "982.1" "880.1" "865.0" "1026.8" "681.9" "" "" "" "" "" "" "" "" "" "" "739.6" "641.0" "874.0" "845.4" "714.9" "982.1" "659.0" "764.0" "918.8" "243.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844416647535235754" "False" "High" "IsMasterProtein" "O00233" "26S proteasome non-ATPase regulatory subunit 9 OS=Homo sapiens OX=9606 GN=PSMD9 PE=1 SV=3" "0.000" "False" "68.822" "43" "10" "33" "10" "223" "24.7" "6.95" "122.89" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf17820, Pf18265" "5715" "ENSG00000110801" "PSMD9" "B2RD35; G3V1Q6; hsa:5715; O00233; Q9BQ42" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.886" "0.904" "0.924" "0.940" "0.914" "0.948" "0.997" "0.933" "0.893" "3734.5" "3309.0" "3374.7" "3452.2" "3509.0" "3414.8" "3539.0" "3724.9" "3484.4" "3334.0" "" "" "" "" "" "" "" "" "" "" "3357.7" "2677.5" "3052.5" "3369.8" "2895.7" "3414.8" "2649.9" "3290.1" "3117.9" "1190.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029493779746441827" "False" "High" "IsMasterProtein" "Q7L1Q6" "eIF5-mimic protein 2 OS=Homo sapiens OX=9606 GN=BZW1 PE=1 SV=1" "0.000" "False" "68.622" "33" "16" "33" "12" "419" "48.0" "5.92" "117.11" "16" "other biological processes" "other cell component" "" "Pf02020" "9689" "ENSG00000082153" "BZW1" "B4DLZ8; B4DWF7; hsa:9689; Q14281; Q15394; Q7L1Q6; Q9BUY0" "" "" "0" "0" "0.952" "0.984" "1.000" "0.948" "0.914" "1.050" "0.883" "0.897" "2.213" "2189.6" "2085.1" "2153.7" "2190.0" "2075.4" "2001.6" "2298.8" "1932.7" "1964.7" "4846.4" "" "" "" "" "" "" "" "" "" "" "1968.7" "1687.2" "1948.1" "2137.7" "1712.7" "2001.6" "1721.3" "1707.1" "1758.0" "1730.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8135385361793162553" "False" "High" "IsMasterProtein" "Q9BQA1" "Methylosome protein WDR77 OS=Homo sapiens OX=9606 GN=WDR77 PE=1 SV=1" "0.000" "False" "68.618" "42" "10" "28" "10" "342" "36.7" "5.17" "119.26" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "79084" "ENSG00000116455" "WDR77" "B3KMW6; B4DP38; hsa:79084; Q3LID2; Q53FU2; Q6JZZ5; Q96GK4; Q9BQA1; Q9BWY3" "" "RMTs methylate histone arginines; snRNP Assembly" "2" "0" "1.029" "0.982" "0.955" "1.045" "0.982" "1.061" "1.054" "0.967" "0.824" "1788.4" "1840.5" "1756.5" "1707.0" "1869.6" "1756.1" "1897.6" "1885.1" "1728.7" "1474.3" "" "" "" "" "" "" "" "" "" "" "1607.9" "1489.3" "1588.9" "1666.3" "1542.9" "1756.1" "1420.8" "1665.1" "1546.9" "526.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5814198643835656164" "False" "High" "IsMasterProtein" "O60711" "Leupaxin OS=Homo sapiens OX=9606 GN=LPXN PE=1 SV=1" "0.000" "False" "68.562" "40" "12" "27" "12" "386" "43.3" "6.01" "100.09" "12" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "9404" "ENSG00000110031" "LPXN" "B2R8B4; B4DV71; hsa:9404; O60711; Q53FW6; Q6FI07" "" "" "0" "0" "0.908" "0.932" "1.014" "0.922" "0.914" "0.964" "1.002" "0.952" "0.916" "2351.6" "2135.2" "2192.1" "2385.5" "2168.6" "2149.3" "2266.9" "2356.8" "2239.9" "2153.1" "" "" "" "" "" "" "" "" "" "" "2114.3" "1727.7" "1982.8" "2328.6" "1789.6" "2149.3" "1697.4" "2081.7" "2004.2" "768.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557205944014884156" "False" "High" "IsMasterProtein" "P20339" "Ras-related protein Rab-5A OS=Homo sapiens OX=9606 GN=RAB5A PE=1 SV=2" "0.000" "False" "68.527" "67" "9" "20" "6" "215" "23.6" "8.15" "82.81" "9" "cell-cell signaling;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5868" "ENSG00000144566" "RAB5A" "B4DJA5; hsa:5868; P20339; Q6FI44" "Amyotrophic lateral sclerosis (ALS); VEGFA-VEGFR2 signaling; Ebola virus infection in host; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; Vasopressin-regulated water reabsorption" "Synthesis of PIPs at the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; Factors involved in megakaryocyte development and platelet production; Prevention of phagosomal-lysosomal fusion; TBC/RABGAPs" "16" "0" "1.000" "1.049" "0.993" "1.030" "0.897" "1.011" "0.946" "0.982" "0.720" "271.3" "271.2" "284.5" "269.2" "279.3" "243.4" "274.3" "256.6" "266.4" "195.2" "" "" "" "" "" "" "" "" "" "" "243.9" "219.4" "257.4" "262.8" "230.5" "243.4" "205.4" "226.6" "238.4" "69.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4915588766185396896" "False" "High" "IsMasterProtein" "Q86U44" "N6-adenosine-methyltransferase catalytic subunit OS=Homo sapiens OX=9606 GN=METTL3 PE=1 SV=2" "0.000" "False" "68.476" "31" "15" "25" "15" "580" "64.4" "6.42" "94.27" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "56339" "ENSG00000165819" "METTL3" "hsa:56339; O14736; Q86U44; Q86V05; Q9HB32" "mRNA processing" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.947" "0.962" "0.967" "0.998" "0.941" "1.019" "1.018" "0.950" "0.872" "1576.9" "1493.6" "1517.3" "1524.4" "1573.1" "1483.6" "1606.2" "1605.0" "1497.8" "1375.1" "" "" "" "" "" "" "" "" "" "" "1417.8" "1208.5" "1372.4" "1488.0" "1298.2" "1483.6" "1202.7" "1417.6" "1340.2" "490.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097595206598813277" "False" "High" "IsMasterProtein" "P09012" "U1 small nuclear ribonucleoprotein A OS=Homo sapiens OX=9606 GN=SNRPA PE=1 SV=3" "0.000" "False" "68.407" "34" "9" "45" "7" "282" "31.3" "9.83" "172.20" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6626" "ENSG00000077312" "SNRPA" "hsa:6626; P09012" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "2" "1.018" "1.038" "0.987" "1.023" "0.995" "1.035" "1.050" "0.983" "0.813" "3727.9" "3793.4" "3871.0" "3679.6" "3813.3" "3708.3" "3859.3" "3913.0" "3664.2" "3029.1" "" "" "" "" "" "" "" "" "" "" "3351.7" "3069.5" "3501.4" "3591.8" "3146.8" "3708.3" "2889.8" "3456.2" "3278.7" "1081.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3264120083815806641" "False" "High" "IsMasterProtein" "O14737" "Programmed cell death protein 5 OS=Homo sapiens OX=9606 GN=PDCD5 PE=1 SV=3" "0.000" "False" "68.404" "67" "10" "37" "10" "125" "14.3" "6.04" "131.28" "10" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01984" "9141" "ENSG00000105185" "PDCD5" "B4DE64; hsa:9141; O14737; Q53YC9; Q6IB70" "" "" "0" "0" "0.984" "0.978" "0.981" "0.935" "0.999" "0.917" "1.036" "0.908" "0.815" "4122.3" "4056.6" "4031.7" "4045.9" "3855.6" "4119.9" "3781.0" "4271.2" "3743.2" "3361.6" "" "" "" "" "" "" "" "" "" "" "3706.3" "3282.4" "3646.8" "3949.4" "3181.7" "4119.9" "2831.1" "3772.6" "3349.4" "1200.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-327475496585371320" "False" "High" "IsMasterProtein" "Q9BWD1" "Acetyl-CoA acetyltransferase, cytosolic OS=Homo sapiens OX=9606 GN=ACAT2 PE=1 SV=2" "0.000" "False" "68.389" "36" "12" "34" "12" "397" "41.3" "6.92" "133.37" "12" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00108, Pf02803" "39" "ENSG00000120437" "ACAT2" "B7Z233; E1P5B1; hsa:39; Q16146; Q5TCL7; Q8TDM4; Q9BWD1" "Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "6" "0" "1.040" "1.099" "1.065" "1.076" "1.081" "1.068" "1.003" "1.127" "0.887" "2418.5" "2514.4" "2657.0" "2575.4" "2603.5" "2613.7" "2583.9" "2426.3" "2726.1" "2146.3" "" "" "" "" "" "" "" "" "" "" "2174.5" "2034.6" "2403.4" "2514.0" "2148.5" "2613.7" "1934.7" "2143.1" "2439.3" "766.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5197563919464376950" "False" "High" "IsMasterProtein" "Q9BTC0" "Death-inducer obliterator 1 OS=Homo sapiens OX=9606 GN=DIDO1 PE=1 SV=5" "0.000" "False" "68.381" "11" "18" "20" "18" "2240" "243.7" "7.88" "74.37" "18" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf07500, Pf07744" "11083" "ENSG00000101191" "DIDO1" "A8MY65; B9EH82; E1P5I1; hsa:11083; O15043; Q3ZTL7; Q3ZTL8; Q4VXS1; Q4VXS2; Q4VXV8; Q4VXV9; Q96D72; Q9BQW0; Q9BTC0; Q9BW03; Q9H4G6; Q9H4G7; Q9NTU8; Q9NUM8; Q9UFB6" "" "" "0" "0" "0.971" "0.958" "0.977" "1.025" "0.991" "1.116" "1.002" "0.906" "1.158" "1402.5" "1361.5" "1343.6" "1370.3" "1437.9" "1390.5" "1564.4" "1405.0" "1270.4" "1623.8" "" "" "" "" "" "" "" "" "" "" "1260.9" "1101.7" "1215.3" "1337.6" "1186.6" "1390.5" "1171.4" "1241.0" "1136.7" "579.7" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7222850354556005820" "False" "High" "IsMasterProtein" "P20839" "Inosine-5'-monophosphate dehydrogenase 1 OS=Homo sapiens OX=9606 GN=IMPDH1 PE=1 SV=2" "0.000" "False" "68.320" "43" "17" "21" "15" "514" "55.4" "6.90" "88.15" "17" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00478, Pf00571" "3614" "ENSG00000106348" "IMPDH1" "A4D0Z6; A4D0Z7; A6NDW5; A6NNI6; B3KNP7; B3KVM8; B4DE09; C9JV30; hsa:3614; J3KNX8; P20839; Q8N194; Q96NU2" "" "Potential therapeutics for SARS; Neutrophil degranulation; Purine ribonucleoside monophosphate biosynthesis; Azathioprine ADME" "4" "0" "1.008" "0.908" "0.964" "0.994" "0.928" "0.973" "1.011" "0.956" "0.807" "2631.2" "2653.6" "2388.3" "2535.9" "2616.6" "2441.2" "2561.0" "2659.4" "2514.5" "2122.4" "" "" "" "" "" "" "" "" "" "" "2365.7" "2147.2" "2160.3" "2475.4" "2159.3" "2441.2" "1917.6" "2348.9" "2250.0" "757.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2254459010250463691" "False" "High" "IsMasterProtein" "Cont_Q3ZBD7" "Glucose-6-phosphate isomerase OS=Bos taurus OX=9913 GN=GPI PE=2 SV=4" "0.000" "True" "68.054" "23" "10" "35" "3" "557" "62.8" "7.71" "141.18" "10" "other metabolic processes;signal transduction" "non-structural extracellular;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00342" "104995211; 109572099; 280808" "ENSBTAG00000006396" "GPI" "A0A6B0R509; A0A6P3HXC3; A0A6P5DB13; biu:109572099; bta:280808; F1MD19; O46595; Q3ZBD7" "Glycolysis and gluconeogenesis; Cori cycle" "TP53 Regulates Metabolic Genes; Neutrophil degranulation; Gluconeogenesis; Glycolysis" "6" "0" "1.000" "0.970" "1.119" "1.002" "1.036" "1.013" "0.979" "1.077" "0.677" "642.7" "642.4" "623.3" "719.2" "643.7" "665.9" "651.3" "629.4" "692.0" "434.8" "" "" "" "" "" "" "" "" "" "" "577.8" "519.8" "563.8" "702.0" "531.2" "665.9" "487.7" "556.0" "619.2" "155.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6460055541994458794" "False" "High" "IsMasterProtein" "Q14019" "Coactosin-like protein OS=Homo sapiens OX=9606 GN=COTL1 PE=1 SV=3" "0.000" "False" "68.052" "84" "15" "65" "15" "142" "15.9" "5.67" "215.18" "15" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "23406" "ENSG00000103187" "COTL1" "B2RDU3; D3DUL9; hsa:23406; Q14019; Q86XM5" "" "Neutrophil degranulation" "1" "0" "0.983" "0.970" "1.002" "0.949" "0.930" "0.978" "0.991" "0.911" "0.738" "6745.4" "6631.0" "6546.4" "6758.5" "6398.3" "6273.3" "6599.5" "6687.0" "6146.5" "4975.9" "" "" "" "" "" "" "" "" "" "" "6064.8" "5365.6" "5921.4" "6597.3" "5280.0" "6273.3" "4941.5" "5906.4" "5499.9" "1776.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6037717816811945701" "False" "High" "IsMasterProtein" "Q5T8P6" "RNA-binding protein 26 OS=Homo sapiens OX=9606 GN=RBM26 PE=1 SV=3" "0.000" "False" "68.034" "16" "15" "19" "15" "1007" "113.5" "9.16" "80.15" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01480" "64062" "ENSG00000139746" "RBM26" "B4DZE0; hsa:64062; Q2NKM2; Q2NKQ2; Q5CZH8; Q5T8P5; Q5T8P6; Q5T8P8; Q5U5P5; Q5W0G7; Q8N3H5; Q96K92; Q96SZ3; Q9H2F8; Q9H7F9; Q9P1G7" "" "" "0" "0" "0.980" "0.967" "0.994" "0.987" "0.925" "1.028" "0.984" "0.893" "1.741" "2140.5" "2097.1" "2069.4" "2127.8" "2112.4" "1980.4" "2200.1" "2105.6" "1912.2" "3726.2" "" "" "" "" "" "" "" "" "" "" "1924.6" "1696.9" "1871.8" "2077.1" "1743.2" "1980.4" "1647.4" "1859.8" "1711.1" "1330.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8330278091767700695" "False" "High" "IsMasterProtein" "Q6PCB5" "Lysine-specific demethylase RSBN1L OS=Homo sapiens OX=9606 GN=RSBN1L PE=1 SV=2" "0.000" "False" "67.994" "20" "17" "23" "16" "846" "94.8" "8.78" "88.77" "17" "" "nucleus" "other molecular function" "" "222194" "ENSG00000187257" "RSBN1L" "C9K0P1; hsa:222194; Q6PCB5; Q6ZS58; Q6ZVI9; Q86X48" "" "" "0" "0" "0.999" "1.010" "0.955" "1.010" "1.060" "0.982" "0.978" "0.914" "0.936" "1443.4" "1442.7" "1458.0" "1378.8" "1458.3" "1530.5" "1416.9" "1411.9" "1319.0" "1351.1" "" "" "" "" "" "" "" "" "" "" "1297.8" "1167.4" "1318.8" "1345.9" "1203.4" "1530.5" "1061.0" "1247.1" "1180.2" "482.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251900378438964283" "False" "High" "IsMasterProtein" "Q13188" "Serine/threonine-protein kinase 3 OS=Homo sapiens OX=9606 GN=STK3 PE=1 SV=2" "0.000" "False" "67.781" "20" "8" "28" "1" "491" "56.3" "5.24" "105.39" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf11629" "6788" "ENSG00000104375" "STK3" "A8K722; B3KYA7; hsa:6788; Q13188; Q15445; Q15801; Q96FM6" "MAPK signaling pathway; Transcription co-factors SKI and SKIL protein partners; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "Signaling by Hippo" "9" "0" "0.998" "0.955" "0.904" "1.000" "0.983" "0.989" "0.997" "0.956" "0.860" "256.7" "256.1" "245.2" "232.1" "256.6" "252.4" "253.9" "256.0" "245.4" "220.9" "" "" "" "" "" "" "" "" "" "" "230.8" "207.2" "221.8" "226.6" "211.8" "252.4" "190.2" "226.1" "219.6" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7328219287373480262" "False" "High" "IsMasterProtein" "Q7LG56" "Ribonucleoside-diphosphate reductase subunit M2 B OS=Homo sapiens OX=9606 GN=RRM2B PE=1 SV=1" "0.000" "False" "67.753" "40" "12" "25" "9" "351" "40.7" "4.97" "93.37" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00268" "50484" "ENSG00000048392" "RRM2B" "B4E2N4; hsa:50484; Q17R22; Q75PQ6; Q75PQ7; Q75PY8; Q75PY9; Q7LG56; Q86YE3; Q9NPD6; Q9NTD8; Q9NUW3" "miRNA regulation of DNA damage response; Pyrimidine metabolism; p53 transcriptional gene network; DNA damage response" "TP53 Regulates Metabolic Genes; Interconversion of nucleotide di- and triphosphates" "6" "0" "1.012" "0.995" "0.964" "1.062" "0.958" "1.013" "1.036" "0.981" "0.808" "1445.6" "1462.3" "1437.9" "1393.7" "1535.6" "1384.2" "1463.8" "1498.2" "1417.6" "1167.6" "" "" "" "" "" "" "" "" "" "" "1299.7" "1183.2" "1300.6" "1360.4" "1267.2" "1384.2" "1096.1" "1323.3" "1268.4" "416.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "193140464994973163" "False" "High" "IsMasterProtein" "P49711" "Transcriptional repressor CTCF OS=Homo sapiens OX=9606 GN=CTCF PE=1 SV=1" "0.000" "False" "67.712" "28" "16" "24" "16" "727" "82.7" "6.96" "89.80" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10664" "ENSG00000102974" "CTCF" "B5MC38; hsa:10664; P49711; Q53XI7; Q59EL8" "MECP2 and associated Rett syndrome; Prion disease pathway; Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors; Sudden infant death syndrome (SIDS) susceptibility pathways" "Activation of anterior HOX genes in hindbrain development during early embryogenesis" "5" "0" "0.916" "0.919" "0.977" "0.957" "0.941" "0.852" "0.962" "0.942" "0.809" "1166.7" "1068.5" "1072.4" "1139.4" "1116.2" "1097.5" "993.5" "1122.0" "1099.1" "944.4" "" "" "" "" "" "" "" "" "" "" "1048.9" "864.6" "970.0" "1112.2" "921.1" "1097.5" "743.9" "991.0" "983.5" "337.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2081784358139501247" "False" "High" "IsMasterProtein" "Q96ME1" "F-box/LRR-repeat protein 18 OS=Homo sapiens OX=9606 GN=FBXL18 PE=1 SV=3" "0.000" "False" "67.581" "27" "17" "25" "17" "718" "78.9" "8.27" "96.13" "17" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937, Pf19729" "80028" "ENSG00000155034" "FBXL18" "A0A024R857; B3KTC9; B4DH63; H0Y6I6; hsa:80028; Q96ME1; Q9BR90; Q9BTC7; Q9HAK7" "" "Antigen processing: Ubiquitination & Proteasome degradation; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Neddylation" "3" "0" "0.995" "1.018" "0.982" "1.041" "0.977" "1.166" "1.002" "0.987" "0.817" "1658.9" "1650.7" "1689.1" "1629.0" "1726.5" "1620.6" "1934.1" "1662.7" "1637.6" "1355.1" "" "" "" "" "" "" "" "" "" "" "1491.5" "1335.7" "1527.8" "1590.2" "1424.7" "1620.6" "1448.2" "1468.6" "1465.3" "483.7" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2084755087725056383" "False" "High" "IsMasterProtein" "P05023" "Sodium/potassium-transporting ATPase subunit alpha-1 OS=Homo sapiens OX=9606 GN=ATP1A1 PE=1 SV=1" "0.000" "False" "67.564" "20" "17" "20" "12" "1023" "112.8" "5.49" "73.69" "17" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "476" "ENSG00000163399" "ATP1A1" "B2RBR6; B7Z2T5; B7Z3U6; F5H3A1; hsa:476; P05023; Q16689; Q6LDM4; Q9UCN1; Q9UJ20; Q9UJ21" "Pre-implantation embryo; Proximal tubule transport; Arsenic metabolism and reactive oxygen species generation" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "6" "4" "0.910" "0.912" "0.969" "0.927" "0.945" "0.957" "0.937" "1.026" "0.720" "1404.2" "1277.7" "1280.9" "1360.3" "1301.5" "1326.5" "1344.5" "1315.5" "1440.7" "1010.8" "" "" "" "" "" "" "" "" "" "" "1262.5" "1033.9" "1158.6" "1327.8" "1074.0" "1326.5" "1006.7" "1162.0" "1289.2" "360.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566941551472469516" "False" "High" "IsMasterProtein" "O60508" "Pre-mRNA-processing factor 17 OS=Homo sapiens OX=9606 GN=CDC40 PE=1 SV=1" "0.000" "False" "67.544" "41" "20" "25" "20" "579" "65.5" "7.06" "90.00" "20" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00400" "51362" "ENSG00000168438" "CDC40" "B2RBC5; hsa:51362; O60508; O75471; Q5SRN0; Q9UPG1" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "5" "0" "0.917" "0.962" "0.964" "0.921" "1.019" "0.915" "0.915" "0.913" "0.750" "1626.5" "1492.1" "1565.0" "1567.5" "1497.7" "1657.0" "1488.4" "1488.1" "1484.9" "1219.4" "" "" "" "" "" "" "" "" "" "" "1462.4" "1207.4" "1415.6" "1530.1" "1235.9" "1657.0" "1114.5" "1314.4" "1328.6" "435.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299507636150983864" "False" "High" "IsMasterProtein" "Q9Y697" "Cysteine desulfurase OS=Homo sapiens OX=9606 GN=NFS1 PE=1 SV=3" "0.000" "False" "67.529" "49" "16" "20" "16" "457" "50.2" "8.31" "77.94" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "9054" "ENSG00000244005" "NFS1" "B3KMA5; B4DXK9; E1P5R8; F5GYK5; hsa:9054; Q6P0L8; Q9NTZ5; Q9Y481; Q9Y697" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.999" "0.993" "1.025" "1.054" "0.977" "1.015" "1.009" "1.007" "0.935" "1215.1" "1214.1" "1206.5" "1246.0" "1280.6" "1187.2" "1233.1" "1226.6" "1223.5" "1135.7" "" "" "" "" "" "" "" "" "" "" "1092.5" "982.4" "1091.4" "1216.2" "1056.8" "1187.2" "923.3" "1083.4" "1094.7" "405.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220187434067665020" "False" "High" "IsMasterProtein" "Q6PJT7" "Zinc finger CCCH domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZC3H14 PE=1 SV=1" "0.000" "False" "67.475" "28" "18" "24" "18" "736" "82.8" "7.31" "82.65" "18" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14608" "79882" "ENSG00000100722" "ZC3H14" "A8MY46; B4DXU8; B4DZW7; B4E2H4; G3V5R4; hsa:79882; Q6MZU4; Q6PJ32; Q6PJT7; Q6PUI6; Q6PUI8; Q86TQ5; Q86TW0; Q86TW1; Q8NCT6; Q8NCZ3; Q8TDE2; Q9HAC9; Q9Y5A0" "" "" "0" "0" "1.031" "1.025" "1.063" "1.036" "1.051" "1.003" "1.118" "1.055" "1.021" "1319.2" "1359.8" "1352.1" "1402.0" "1366.1" "1385.9" "1322.6" "1474.4" "1392.3" "1347.5" "" "" "" "" "" "" "" "" "" "" "1186.1" "1100.3" "1223.0" "1368.6" "1127.3" "1385.9" "990.3" "1302.3" "1245.8" "481.0" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174444924925407144" "False" "High" "IsMasterProtein" "P61088" "Ubiquitin-conjugating enzyme E2 N OS=Homo sapiens OX=9606 GN=UBE2N PE=1 SV=1" "0.000" "False" "67.432" "61" "11" "46" "11" "152" "17.1" "6.57" "163.01" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7334" "ENSG00000177889" "UBE2N" "hsa:7334; P61088; Q16781; Q53Y81" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway; Prader-Willi and Angelman syndrome; 3q29 copy number variation syndrome" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; Nonhomologous End-Joining (NHEJ); Formation of Incision Complex in GG-NER; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "28" "0" "1.013" "1.014" "1.078" "1.028" "0.986" "1.010" "1.032" "1.038" "0.761" "4390.3" "4447.1" "4451.6" "4733.4" "4512.4" "4326.8" "4433.2" "4532.3" "4558.7" "3340.7" "" "" "" "" "" "" "" "" "" "" "3947.3" "3598.5" "4026.7" "4620.4" "3723.7" "4326.8" "3319.5" "4003.2" "4079.0" "1192.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7242737941757580841" "False" "High" "IsMasterProtein" "P54105" "Methylosome subunit pICln OS=Homo sapiens OX=9606 GN=CLNS1A PE=1 SV=1" "0.000" "False" "67.294" "48" "7" "27" "7" "237" "26.2" "4.11" "119.05" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf03517" "1207" "ENSG00000074201" "CLNS1A" "B2RCS9; hsa:1207; P54105; Q0VDK6; Q9NRD2; Q9NRD3" "" "snRNP Assembly" "1" "0" "0.974" "1.114" "1.007" "1.024" "1.175" "0.994" "1.010" "1.144" "0.931" "1641.9" "1599.3" "1829.3" "1653.7" "1681.7" "1929.3" "1632.1" "1658.1" "1879.0" "1528.8" "" "" "" "" "" "" "" "" "" "" "1476.3" "1294.1" "1654.6" "1614.3" "1387.7" "1929.3" "1222.0" "1464.5" "1681.3" "545.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "699961986535192658" "False" "High" "IsMasterProtein" "P84095" "Rho-related GTP-binding protein RhoG OS=Homo sapiens OX=9606 GN=RHOG PE=1 SV=1" "0.000" "False" "67.196" "60" "8" "22" "7" "191" "21.3" "8.12" "100.30" "8" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071" "391" "ENSG00000177105" "RHOG" "hsa:391; P35238; P84095; Q8NI04" "Brain-derived neurotrophic factor (BDNF) signaling pathway" "Neutrophil degranulation; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; RHOG GTPase cycle; RHO GTPases activate KTN1" "8" "0" "0.983" "1.044" "1.034" "1.035" "0.987" "0.978" "1.053" "0.979" "0.868" "2365.8" "2326.0" "2469.1" "2447.3" "2448.5" "2334.3" "2313.0" "2492.3" "2316.8" "2053.6" "" "" "" "" "" "" "" "" "" "" "2127.1" "1882.1" "2233.4" "2388.9" "2020.5" "2334.3" "1731.9" "2201.3" "2073.1" "733.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-519635040323081051" "False" "High" "IsMasterProtein" "P60953" "Cell division control protein 42 homolog OS=Homo sapiens OX=9606 GN=CDC42 PE=1 SV=2" "0.000" "False" "67.113" "48" "9" "39" "8" "191" "21.2" "6.55" "154.04" "9" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "998" "ENSG00000070831" "CDC42" "hsa:998; P21181; P25763; P60953; Q7L8R5; Q9UDI2" "Androgen receptor signaling pathway; Target of rapamycin signaling; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Metastatic brain tumor; Pathogenic Escherichia coli infection; RalA downstream regulated genes; B cell receptor signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Focal adhesion; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; p38 MAPK signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; 22q11.2 copy number variation syndrome; Gastrin signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; 13q12.12 copy number variation; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RHO GTPases Activate Formins; RHOV GTPase cycle; RHOU GTPase cycle; VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; MAPK6/MAPK4 signaling; RHO GTPases Activate WASPs and WAVEs; RHO GTPases activate IQGAPs; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; EPHB-mediated forward signaling; DCC mediated attractive signaling; GPVI-mediated activation cascade; Myogenesis; Factors involved in megakaryocyte development and platelet production; G beta:gamma signalling through CDC42; EGFR downregulation; RHO GTPases activate PAKs; Inactivation of CDC42 and RAC1; CD28 dependent Vav1 pathway; RHO GTPases activate KTN1" "63" "0" "0.985" "1.033" "1.100" "1.008" "1.003" "0.971" "1.065" "0.992" "0.833" "5879.1" "5789.0" "6074.9" "6467.9" "5925.5" "5896.3" "5709.0" "6261.4" "5833.6" "4900.1" "" "" "" "" "" "" "" "" "" "" "5285.9" "4684.3" "5494.9" "6313.6" "4889.8" "5896.3" "4274.7" "5530.4" "5219.9" "1749.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4097484419734302186" "False" "High" "IsMasterProtein" "Q9UBL3" "Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Homo sapiens OX=9606 GN=ASH2L PE=1 SV=1" "0.000" "False" "67.102" "30" "18" "24" "18" "628" "68.7" "5.69" "76.46" "18" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00622, Pf21198, Pf21257" "9070" "ENSG00000129691" "ASH2L" "A8K7C3; D3DSW9; hsa:9070; O60659; O60660; Q96B62; Q9UBL3" "Kleefstra syndrome" "Deactivation of the beta-catenin transactivating complex; Formation of the beta-catenin:TCF transactivating complex; Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "7" "0" "0.957" "1.065" "1.091" "1.018" "1.041" "0.926" "1.046" "1.067" "0.907" "931.5" "891.2" "992.0" "1016.6" "948.5" "970.1" "862.6" "974.0" "994.3" "845.2" "" "" "" "" "" "" "" "" "" "" "837.6" "721.1" "897.3" "992.4" "782.7" "970.1" "645.9" "860.3" "889.7" "301.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112180940687261840" "False" "High" "IsMasterProtein" "Q15185" "Prostaglandin E synthase 3 OS=Homo sapiens OX=9606 GN=PTGES3 PE=1 SV=1" "0.000" "False" "67.086" "53" "9" "39" "9" "160" "18.7" "4.54" "156.61" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04969" "10728" "ENSG00000110958" "PTGES3" "A8K7D0; B4DHP2; B4DP11; B4DP21; hsa:10728; Q15185; Q8WU70" "Aryl hydrocarbon receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Omega-6-fatty acids in senescence" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Potential therapeutics for SARS; Aryl hydrocarbon receptor signalling; Estrogen-dependent gene expression; Synthesis of Prostaglandins (PG) and Thromboxanes (TX); HSF1 activation; Attenuation phase" "12" "0" "0.990" "1.007" "1.001" "1.025" "1.107" "1.020" "1.099" "0.990" "1.106" "3657.0" "3621.4" "3681.6" "3661.3" "3748.3" "4046.9" "3730.1" "4017.9" "3621.2" "4045.5" "" "" "" "" "" "" "" "" "" "" "3288.0" "2930.3" "3330.1" "3573.9" "3093.2" "4046.9" "2793.0" "3548.9" "3240.2" "1444.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4576818443980197018" "False" "High" "IsMasterProtein" "P52292" "Importin subunit alpha-1 OS=Homo sapiens OX=9606 GN=KPNA2 PE=1 SV=1" "0.000" "False" "67.026" "33" "14" "22" "14" "529" "57.8" "5.40" "98.80" "14" "DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3838" "ENSG00000182481" "KPNA2" "B9EJD6; hsa:3838; P52292; Q53YE3; Q6NVW7; Q9BRU5" "" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Estrogen-dependent gene expression; SARS-CoV-1 activates/modulates innate immune responses; Sensing of DNA Double Strand Breaks; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "8" "0" "1.026" "0.945" "1.020" "1.062" "0.992" "1.127" "0.976" "0.994" "4.229" "1260.4" "1293.3" "1190.8" "1285.0" "1338.6" "1250.9" "1420.2" "1230.7" "1253.2" "5330.2" "" "" "" "" "" "" "" "" "" "" "1133.2" "1046.5" "1077.1" "1254.3" "1104.6" "1250.9" "1063.4" "1087.0" "1121.3" "1902.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819475231177228561" "False" "High" "IsMasterProtein" "O94966" "Ubiquitin carboxyl-terminal hydrolase 19 OS=Homo sapiens OX=9606 GN=USP19 PE=1 SV=2" "0.000" "False" "67.007" "16" "15" "20" "15" "1318" "145.6" "6.28" "81.45" "15" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00443, Pf01753, Pf04969, Pf16602" "10869" "ENSG00000172046" "USP19" "A5PKX8; A6H8U2; B4DGT3; B4DTZ0; E7EN22; E7ETS0; E9PEG8; hsa:10869; O94966; Q3KQW4; Q641Q9; Q6NZY8; Q86XV9" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases" "2" "0" "1.085" "1.044" "1.058" "1.108" "1.067" "1.074" "1.048" "1.088" "1.011" "1211.7" "1314.7" "1264.6" "1282.5" "1342.1" "1293.0" "1301.7" "1270.2" "1318.1" "1225.4" "" "" "" "" "" "" "" "" "" "" "1089.4" "1063.8" "1143.9" "1251.9" "1107.6" "1293.0" "974.7" "1121.9" "1179.5" "437.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7983353042055504763" "False" "High" "IsMasterProtein" "Q6SZW1" "NAD(+) hydrolase SARM1 OS=Homo sapiens OX=9606 GN=SARM1 PE=1 SV=1" "0.000" "False" "66.712" "28" "17" "22" "17" "724" "79.3" "6.55" "81.25" "17" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf07647, Pf13676" "23098" "ENSG00000004139" "SARM1" "hsa:23098; O60277; Q6SZW1; Q7LGG3; Q9NXY5" "" "" "0" "0" "1.061" "0.998" "0.985" "1.117" "1.005" "1.025" "1.031" "1.048" "1.104" "1071.0" "1136.4" "1068.6" "1055.1" "1195.9" "1076.2" "1097.9" "1104.1" "1122.7" "1182.1" "" "" "" "" "" "" "" "" "" "" "962.9" "919.5" "966.6" "1029.9" "986.8" "1076.2" "822.1" "975.3" "1004.6" "422.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491360545906137157" "False" "High" "IsMasterProtein" "P54920" "Alpha-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPA PE=1 SV=3" "0.000" "False" "66.689" "59" "14" "21" "14" "295" "33.2" "5.36" "86.87" "14" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf14938" "8775" "ENSG00000105402" "NAPA" "A8K879; hsa:8775; P54920; Q96IK3; Q9BVJ3" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Golgi Associated Vesicle Biogenesis; Intra-Golgi traffic; COPII-mediated vesicle transport; Retrograde transport at the Trans-Golgi-Network" "8" "0" "0.947" "0.989" "1.032" "1.010" "0.991" "1.019" "1.012" "1.041" "0.768" "1802.2" "1707.1" "1782.2" "1859.0" "1819.6" "1786.9" "1836.5" "1823.1" "1875.3" "1383.2" "" "" "" "" "" "" "" "" "" "" "1620.4" "1381.3" "1612.1" "1814.7" "1501.6" "1786.9" "1375.1" "1610.3" "1678.0" "493.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3906185605223521012" "False" "High" "IsMasterProtein" "Q9BY32" "Inosine triphosphate pyrophosphatase OS=Homo sapiens OX=9606 GN=ITPA PE=1 SV=2" "0.000" "False" "66.688" "63" "9" "20" "9" "194" "21.4" "5.66" "89.22" "9" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01725" "3704" "ENSG00000125877" "ITPA" "A2A2N2; A4UIM5; B2BCH7; hsa:3704; O14878; Q5JWH4; Q9BY32; Q9BYN1; Q9BYX0; Q9H3H8" "" "Purine catabolism; Ribavirin ADME" "2" "0" "1.023" "1.003" "1.016" "1.040" "0.983" "1.000" "1.047" "1.043" "0.831" "1946.0" "1991.7" "1952.0" "1977.3" "2024.2" "1913.2" "1945.5" "2037.3" "2029.4" "1617.1" "" "" "" "" "" "" "" "" "" "" "1749.7" "1611.6" "1765.7" "1930.2" "1670.4" "1913.2" "1456.8" "1799.5" "1815.9" "577.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2236702861585061595" "False" "High" "IsMasterProtein" "P57721" "Poly(rC)-binding protein 3 OS=Homo sapiens OX=9606 GN=PCBP3 PE=1 SV=2" "0.000" "False" "66.482" "21" "7" "48" "1" "371" "39.4" "8.07" "164.35" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity" "Pf00013, Pf07650" "54039" "ENSG00000183570" "PCBP3" "A8MPS2; A8MQ26; B7WNN9; B7WPC1; P57721; Q8N9K6; Q96EP6" "" "" "0" "0" "1.048" "1.011" "1.002" "1.027" "1.006" "0.990" "1.006" "0.990" "1.104" "789.7" "828.0" "798.7" "791.0" "810.7" "794.4" "782.0" "794.5" "781.7" "871.5" "" "" "" "" "" "" "" "" "" "" "710.0" "670.0" "722.4" "772.1" "669.0" "794.4" "585.5" "701.8" "699.4" "311.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651766820472939276" "False" "High" "IsMasterProtein" "Q12792" "Twinfilin-1 OS=Homo sapiens OX=9606 GN=TWF1 PE=1 SV=3" "0.000" "False" "66.463" "49" "16" "25" "12" "350" "40.3" "6.96" "95.65" "16" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00241" "5756" "ENSG00000151239" "TWF1" "A8K5A8; B3KXS6; B4DLX9; hsa:5756; Q12792; Q59G07; Q5U0B1; Q6FHJ1; Q6FHL6; Q6NUK9; Q86XL6; Q8TCD3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; RHOBTB2 GTPase cycle" "3" "0" "0.999" "0.993" "0.938" "1.031" "0.984" "0.998" "0.978" "1.007" "0.747" "2220.6" "2219.2" "2204.8" "2082.6" "2289.0" "2185.4" "2216.0" "2171.4" "2237.0" "1659.8" "" "" "" "" "" "" "" "" "" "" "1996.5" "1795.7" "1994.4" "2032.9" "1889.0" "2185.4" "1659.3" "1917.9" "2001.6" "592.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9080862626962095597" "False" "High" "IsMasterProtein" "O75312" "Zinc finger protein ZPR1 OS=Homo sapiens OX=9606 GN=ZPR1 PE=1 SV=1" "0.000" "False" "66.402" "37" "14" "22" "14" "459" "50.9" "4.73" "83.69" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03367" "8882" "ENSG00000109917" "ZPR1" "hsa:8882; O75312; Q2TAA0" "" "" "0" "0" "1.008" "1.010" "0.980" "1.093" "1.040" "1.125" "1.065" "1.051" "0.978" "2099.4" "2116.1" "2120.3" "2058.3" "2294.6" "2182.5" "2362.3" "2235.2" "2206.3" "2053.1" "" "" "" "" "" "" "" "" "" "" "1887.6" "1712.3" "1917.9" "2009.2" "1893.6" "2182.5" "1768.8" "1974.3" "1974.1" "732.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8647128743561798150" "False" "High" "IsMasterProtein" "P78417" "Glutathione S-transferase omega-1 OS=Homo sapiens OX=9606 GN=GSTO1 PE=1 SV=2" "0.000" "False" "66.290" "46" "12" "35" "12" "241" "27.5" "6.60" "119.76" "12" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13409, Pf14497" "9446" "ENSG00000148834" "GSTO1" "D3DRA3; F5H7H0; hsa:9446; P78417; Q5TA03; Q7Z3T2" "Myometrial relaxation and contraction pathways; Arsenic metabolism and reactive oxygen species generation; Metapathway biotransformation Phase I and II" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Glutathione conjugation; Vitamin C (ascorbate) metabolism; Methylation" "7" "0" "0.975" "0.987" "0.962" "0.994" "0.924" "1.013" "1.016" "0.954" "0.793" "4183.5" "4078.9" "4129.3" "4024.1" "4160.1" "3863.8" "4239.7" "4251.6" "3989.0" "3317.1" "" "" "" "" "" "" "" "" "" "" "3761.4" "3300.5" "3735.1" "3928.1" "3433.0" "3863.8" "3174.6" "3755.3" "3569.3" "1184.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415570283207223737" "False" "High" "IsMasterProtein" "Q08257" "Quinone oxidoreductase OS=Homo sapiens OX=9606 GN=CRYZ PE=1 SV=1" "0.000" "False" "66.121" "53" "14" "25" "14" "329" "35.2" "8.44" "95.17" "14" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf08240, Pf13602" "1429" "ENSG00000116791" "CRYZ" "A6NN60; D3DQ76; hsa:1429; Q08257; Q53FT0; Q59EU7; Q5HYE7; Q6NSK9" "" "" "0" "0" "1.060" "0.995" "1.029" "1.062" "0.982" "1.021" "1.034" "1.035" "0.791" "2704.0" "2866.5" "2690.4" "2781.8" "2871.9" "2654.4" "2760.9" "2796.8" "2797.7" "2138.2" "" "" "" "" "" "" "" "" "" "" "2431.1" "2319.4" "2433.6" "2715.5" "2369.9" "2654.4" "2067.3" "2470.3" "2503.4" "763.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4690988044632206279" "False" "High" "IsMasterProtein" "Q16719" "Kynureninase OS=Homo sapiens OX=9606 GN=KYNU PE=1 SV=1" "0.000" "False" "66.113" "38" "15" "22" "15" "465" "52.3" "7.03" "86.63" "15" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00266" "8942" "ENSG00000115919" "KYNU" "B2RCZ5; D3DP79; hsa:8942; Q16719; Q6I9T2; Q9BVW3" "Selenium micronutrient network; NAD biosynthesis II (from tryptophan); Tryptophan metabolism" "Tryptophan catabolism" "4" "0" "0.993" "1.035" "1.059" "0.962" "0.986" "0.990" "1.031" "0.995" "0.750" "2267.2" "2250.5" "2345.6" "2401.1" "2180.2" "2235.1" "2244.7" "2337.9" "2255.6" "1699.3" "" "" "" "" "" "" "" "" "" "" "2038.5" "1821.0" "2121.7" "2343.8" "1799.2" "2235.1" "1680.8" "2065.0" "2018.3" "606.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713269859164182683" "False" "High" "IsMasterProtein" "P08567" "Pleckstrin OS=Homo sapiens OX=9606 GN=PLEK PE=1 SV=3" "0.000" "False" "66.085" "34" "10" "26" "10" "350" "40.1" "8.28" "109.62" "10" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00169, Pf00610" "5341" "ENSG00000115956" "PLEK" "B2R9E8; hsa:5341; P08567; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81" "Serotonin and anxiety-related events; TYROBP causal network in microglia; Serotonin and anxiety" "Platelet degranulation" "4" "0" "1.116" "1.111" "1.135" "1.019" "1.091" "0.957" "1.053" "1.161" "0.988" "1950.1" "2176.8" "2166.3" "2212.6" "1987.5" "2127.6" "1865.9" "2053.0" "2264.1" "1926.5" "" "" "" "" "" "" "" "" "" "" "1753.3" "1761.4" "1959.5" "2159.8" "1640.1" "2127.6" "1397.1" "1813.4" "2025.9" "687.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2652497111054879184" "False" "High" "IsMasterProtein" "Q96HE7" "ERO1-like protein alpha OS=Homo sapiens OX=9606 GN=ERO1A PE=1 SV=2" "0.000" "False" "66.043" "34" "14" "22" "14" "468" "54.4" "5.68" "83.14" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04137" "30001" "ENSG00000197930" "ERO1A" "A8K9X4; A8MYW1; hsa:30001; Q7LD45; Q96HE7; Q9P1Q9; Q9UKV6" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.001" "0.974" "0.990" "1.039" "0.990" "1.060" "1.023" "0.986" "0.905" "2117.2" "2119.1" "2061.1" "2095.2" "2200.1" "2095.9" "2245.0" "2166.2" "2087.6" "1915.6" "" "" "" "" "" "" "" "" "" "" "1903.5" "1714.7" "1864.4" "2045.2" "1815.5" "2095.9" "1681.0" "1913.4" "1867.9" "683.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7705673583208632788" "False" "High" "IsMasterProtein" "P04183" "Thymidine kinase, cytosolic OS=Homo sapiens OX=9606 GN=TK1 PE=1 SV=2" "0.000" "False" "66.025" "53" "12" "29" "12" "234" "25.5" "8.51" "93.14" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00265" "7083" "ENSG00000167900" "TK1" "B2RC58; hsa:7083; P04183; Q969V0; Q9UMG9" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage; G1/S-Specific Transcription" "4" "0" "1.046" "1.760" "0.958" "1.056" "1.667" "1.086" "0.992" "1.742" "0.951" "1299.2" "1358.8" "2286.2" "1244.7" "1372.3" "2166.3" "1410.8" "1289.0" "2263.7" "1235.2" "" "" "" "" "" "" "" "" "" "" "1168.1" "1099.5" "2067.9" "1215.0" "1132.5" "2166.3" "1056.4" "1138.5" "2025.6" "440.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6289921617317730415" "False" "High" "IsMasterProtein" "Q9BWF3" "RNA-binding protein 4 OS=Homo sapiens OX=9606 GN=RBM4 PE=1 SV=1" "0.000" "False" "66.024" "43" "15" "28" "15" "364" "40.3" "7.08" "93.09" "15" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00098" "5936" "ENSG00000173933" "RBM4" "B3KUN0; B4E1U0; E7EQS3; hsa:5936; O02916; Q4VC48; Q6P1P2; Q8WU85; Q9BWF3" "" "Circadian Clock" "1" "0" "0.968" "1.135" "1.020" "1.019" "1.096" "1.015" "0.995" "1.102" "2.305" "1856.1" "1796.0" "2107.5" "1893.8" "1892.1" "2033.6" "1883.2" "1846.6" "2045.6" "4278.2" "" "" "" "" "" "" "" "" "" "" "1668.8" "1453.3" "1906.3" "1848.6" "1561.4" "2033.6" "1410.1" "1631.1" "1830.4" "1527.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198738028437086806" "False" "High" "IsMasterProtein" "Q7Z2W4" "Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens OX=9606 GN=ZC3HAV1 PE=1 SV=3" "0.000" "False" "65.973" "23" "15" "18" "15" "902" "101.4" "8.40" "79.50" "15" "stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00644, Pf02825, Pf18606, Pf18633" "56829" "ENSG00000105939" "ZC3HAV1" "A4D1R2; A4D1S4; hsa:56829; Q7Z2W4; Q8IW57; Q8TAJ3; Q96N79; Q9H8R9; Q9P0Y7" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.987" "0.978" "0.982" "1.014" "1.017" "1.057" "1.042" "1.086" "1.237" "794.7" "784.3" "777.4" "780.6" "805.9" "808.3" "840.1" "828.3" "863.1" "982.8" "" "" "" "" "" "" "" "" "" "" "714.5" "634.6" "703.2" "761.9" "665.1" "808.3" "629.0" "731.6" "772.3" "350.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8447148284608472051" "False" "High" "IsMasterProtein" "Q9H444" "Charged multivesicular body protein 4b OS=Homo sapiens OX=9606 GN=CHMP4B PE=1 SV=1" "0.000" "False" "65.972" "50" "15" "31" "15" "224" "24.9" "4.82" "112.40" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "128866" "ENSG00000101421" "CHMP4B" "E1P5N4; hsa:128866; Q53ZD6; Q9H444" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.868" "0.937" "0.930" "0.939" "0.937" "0.947" "0.998" "0.998" "0.752" "3564.8" "3095.5" "3338.5" "3314.0" "3346.1" "3339.4" "3376.5" "3559.1" "3559.0" "2681.6" "" "" "" "" "" "" "" "" "" "" "3205.1" "2504.7" "3019.8" "3234.9" "2761.3" "3339.4" "2528.2" "3143.6" "3184.5" "957.3" "16" "16" "16" "16" "16" "16" "16" "16" "16" "16" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325736081283403068" "False" "High" "IsMasterProtein" "P35637" "RNA-binding protein FUS OS=Homo sapiens OX=9606 GN=FUS PE=1 SV=1" "0.000" "False" "65.953" "20" "9" "35" "7" "526" "53.4" "9.36" "120.37" "9" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641" "2521" "ENSG00000089280" "FUS" "hsa:2521; P35637; Q9H4A8" "MECP2 and associated Rett syndrome; mRNA processing; HDAC6 interactions in the central nervous system" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "5" "2" "1.054" "1.070" "0.966" "1.079" "1.213" "0.947" "1.057" "0.991" "0.761" "2909.1" "3067.6" "3113.5" "2810.8" "3137.6" "3529.6" "2756.3" "3074.5" "2883.6" "2214.6" "" "" "" "" "" "" "" "" "" "" "2615.6" "2482.2" "2816.3" "2743.8" "2589.2" "3529.6" "2063.9" "2715.6" "2580.3" "790.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1941852327752543049" "False" "High" "IsMasterProtein" "Q93009" "Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens OX=9606 GN=USP7 PE=1 SV=2" "0.000" "False" "65.917" "18" "18" "22" "18" "1102" "128.2" "5.55" "73.94" "18" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf00917, Pf12436, Pf14533" "7874" "ENSG00000187555" "USP7" "A6NMY8; B7Z815; H0Y3G8; hsa:7874; Q93009" "Nucleotide excision repair in xeroderma pigmentosum ; Warburg effect modulated by deubiquitinating enzymes and their substrates" "Ub-specific processing proteases; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Regulation of TP53 Degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Formation of TC-NER Pre-Incision Complex; Regulation of PTEN localization" "10" "0" "0.933" "0.921" "0.988" "0.949" "0.866" "1.003" "0.818" "0.858" "3.233" "1702.6" "1588.2" "1568.4" "1682.7" "1616.2" "1474.0" "1707.3" "1392.1" "1460.7" "5504.3" "" "" "" "" "" "" "" "" "" "" "1530.8" "1285.1" "1418.7" "1642.5" "1333.7" "1474.0" "1278.4" "1229.6" "1307.0" "1964.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939496649029224586" "False" "High" "IsMasterProtein" "P51812" "Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens OX=9606 GN=RPS6KA3 PE=1 SV=1" "0.000" "False" "65.913" "26" "20" "24" "11" "740" "83.7" "6.89" "75.52" "20" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00433" "6197" "ENSG00000177189" "RPS6KA3" "B2R9V4; hsa:6197; P51812; Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Thermogenesis; EGF/EGFR signaling pathway; Cytoplasmic ribosomal proteins; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Macrophage-stimulating protein (MSP) signaling network map" "Senescence-Associated Secretory Phenotype (SASP); Recycling pathway of L1; RSK activation; ERK/MAPK targets; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK" "18" "0" "1.096" "1.083" "0.966" "1.029" "1.070" "1.090" "1.013" "1.003" "1.069" "317.2" "347.6" "343.4" "306.6" "326.5" "339.5" "345.9" "321.4" "318.2" "339.2" "" "" "" "" "" "" "" "" "" "" "285.2" "281.3" "310.6" "299.3" "269.4" "339.5" "259.0" "283.9" "284.7" "121.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9167307694424558965" "False" "High" "IsMasterProtein" "O95336" "6-phosphogluconolactonase OS=Homo sapiens OX=9606 GN=PGLS PE=1 SV=2" "0.000" "False" "65.838" "59" "11" "31" "11" "258" "27.5" "6.05" "126.08" "11" "other metabolic processes" "cytosol" "other molecular function" "Pf01182" "25796" "ENSG00000130313" "PGLS" "hsa:25796; O95336" "Pentose phosphate metabolism" "Pentose phosphate pathway" "2" "0" "1.028" "0.959" "0.968" "1.058" "0.966" "1.018" "1.046" "0.958" "0.864" "2247.9" "2310.3" "2156.8" "2176.9" "2377.9" "2172.4" "2288.7" "2350.6" "2153.6" "1941.5" "" "" "" "" "" "" "" "" "" "" "2021.1" "1869.4" "1950.9" "2125.0" "1962.3" "2172.4" "1713.7" "2076.2" "1927.1" "693.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5370481134034691073" "False" "High" "IsMasterProtein" "P22307" "Sterol carrier protein 2 OS=Homo sapiens OX=9606 GN=SCP2 PE=1 SV=2" "0.000" "False" "65.730" "16" "10" "24" "10" "547" "59.0" "6.89" "101.25" "10" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf00108, Pf02036, Pf02803" "6342" "ENSG00000116171" "SCP2" "A6NM69; B4DGJ9; B4DHP6; C9JC79; D3DQ37; E1B6W5; F2Z3J1; hsa:6342; P22307; Q15432; Q16622; Q5VVZ1; Q6NXF4; Q99430" "PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Mitochondrial fatty acid oxidation disorders; DNA damage response (only ATM dependent)" "TYSND1 cleaves peroxisomal proteins; alpha-linolenic acid (ALA) metabolism" "10" "0" "0.817" "1.008" "0.899" "0.985" "1.008" "1.000" "1.004" "1.067" "0.675" "2614.6" "2137.1" "2636.5" "2351.3" "2574.7" "2636.4" "2614.9" "2624.1" "2790.0" "1764.9" "" "" "" "" "" "" "" "" "" "" "2350.8" "1729.2" "2384.8" "2295.2" "2124.7" "2636.4" "1958.0" "2317.8" "2496.5" "630.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3764850706603646464" "False" "High" "IsMasterProtein" "Q9ULC4" "Malignant T-cell-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MCTS1 PE=1 SV=1" "0.000" "False" "65.700" "57" "8" "26" "3" "181" "20.5" "8.82" "100.89" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "28985" "ENSG00000232119" "MCTS1" "B4DGY2; hsa:28985; Q502X6; Q9ULC4" "" "" "0" "6" "1.005" "0.972" "1.008" "1.057" "1.024" "0.998" "1.031" "1.016" "0.858" "1793.0" "1801.9" "1742.5" "1807.4" "1894.8" "1835.3" "1790.3" "1848.4" "1821.6" "1538.1" "" "" "" "" "" "" "" "" "" "" "1612.1" "1458.1" "1576.1" "1764.2" "1563.7" "1835.3" "1340.6" "1632.6" "1630.0" "549.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6176732133664384368" "False" "High" "IsMasterProtein" "Q70CQ2" "Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens OX=9606 GN=USP34 PE=1 SV=2" "0.000" "False" "65.656" "7" "24" "29" "24" "3546" "404.0" "5.82" "83.21" "24" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443, Pf12030" "9736" "ENSG00000115464" "USP34" "A8MWD0; B3KWU9; hsa:9736; O60316; O94834; Q3B777; Q6P6C9; Q70CQ2; Q7L8P6; Q8N3T9; Q8TBW2; Q9UGA1" "" "Ub-specific processing proteases; TCF dependent signaling in response to WNT" "2" "0" "1.020" "0.943" "0.924" "1.017" "0.929" "1.010" "0.924" "0.986" "1.407" "1305.2" "1330.9" "1230.2" "1206.4" "1327.5" "1213.1" "1317.9" "1205.9" "1287.3" "1835.9" "" "" "" "" "" "" "" "" "" "" "1173.5" "1076.9" "1112.8" "1177.6" "1095.5" "1213.1" "986.8" "1065.1" "1151.8" "655.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8097806180956091720" "False" "High" "IsMasterProtein" "Q16576" "Histone-binding protein RBBP7 OS=Homo sapiens OX=9606 GN=RBBP7 PE=1 SV=1" "0.000" "False" "65.621" "37" "13" "42" "7" "425" "47.8" "5.05" "159.11" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "5931" "ENSG00000102054" "RBBP7" "hsa:5931; Q16576; Q5JP00" "Retinoblastoma gene in cancer; Interactome of polycomb repressive complex 2 (PRC2) ; Effect of progerin on genes involved in progeria" "HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Neddylation; Potential therapeutics for SARS; Deposition of new CENPA-containing nucleosomes at the centromere; Transcriptional Regulation by E2F6; HDACs deacetylate histones; RMTs methylate histone arginines; PKMTs methylate histone lysines; HATs acetylate histones; RNA Polymerase I Transcription Initiation; PRC2 methylates histones and DNA; Defective pyroptosis; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "20" "4" "0.986" "1.019" "1.031" "1.009" "1.004" "0.979" "1.036" "1.030" "0.893" "3237.8" "3191.7" "3299.9" "3338.5" "3266.2" "3251.4" "3170.7" "3355.3" "3335.9" "2889.9" "" "" "" "" "" "" "" "" "" "" "2911.1" "2582.6" "2984.8" "3258.8" "2695.3" "3251.4" "2374.1" "2963.7" "2984.9" "1031.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4457645785715096452" "False" "High" "IsMasterProtein" "Q9BS26" "Endoplasmic reticulum resident protein 44 OS=Homo sapiens OX=9606 GN=ERP44 PE=1 SV=1" "0.000" "False" "65.606" "36" "14" "28" "13" "406" "46.9" "5.26" "98.28" "14" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085, Pf13848" "23071" "ENSG00000023318" "ERP44" "hsa:23071; O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67; Q9BS26" "" "Neutrophil degranulation" "1" "0" "1.069" "1.127" "1.046" "1.149" "1.101" "1.059" "1.120" "1.153" "0.763" "1986.9" "2123.3" "2239.7" "2077.7" "2283.4" "2187.9" "2103.7" "2224.9" "2291.5" "1515.5" "" "" "" "" "" "" "" "" "" "" "1786.4" "1718.1" "2025.9" "2028.1" "1884.3" "2187.9" "1575.2" "1965.1" "2050.4" "541.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2588985702309620212" "False" "High" "IsMasterProtein" "O75792" "Ribonuclease H2 subunit A OS=Homo sapiens OX=9606 GN=RNASEH2A PE=1 SV=2" "0.000" "False" "65.591" "44" "12" "20" "12" "299" "33.4" "5.25" "73.94" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01351" "10535" "ENSG00000104889" "RNASEH2A" "B2RCY1; hsa:10535; O75792; Q96F11" "" "" "0" "0" "0.942" "0.963" "1.055" "1.022" "0.974" "0.982" "0.973" "0.944" "1.187" "1656.1" "1559.7" "1594.9" "1747.5" "1692.1" "1613.8" "1626.4" "1611.6" "1564.1" "1965.9" "" "" "" "" "" "" "" "" "" "" "1489.0" "1262.1" "1442.6" "1705.8" "1396.4" "1613.8" "1217.8" "1423.5" "1399.5" "701.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7186431258293956911" "False" "High" "IsMasterProtein" "Q04837" "Single-stranded DNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SSBP1 PE=1 SV=1" "0.000" "False" "65.449" "57" "8" "51" "8" "148" "17.2" "9.60" "182.30" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00436" "6742" "ENSG00000106028; ENSG00000262771" "SSBP1" "hsa:6742; Q04837" "" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "2" "0" "0.967" "0.954" "1.098" "0.956" "0.982" "0.966" "0.992" "0.983" "0.769" "4438.6" "4290.5" "4234.6" "4873.8" "4243.6" "4356.8" "4289.1" "4402.7" "4364.0" "3412.9" "" "" "" "" "" "" "" "" "" "" "3990.7" "3471.7" "3830.4" "4757.5" "3501.9" "4356.8" "3211.6" "3888.7" "3904.9" "1218.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8904894331141024633" "False" "High" "IsMasterProtein" "Q04726" "Transducin-like enhancer protein 3 OS=Homo sapiens OX=9606 GN=TLE3 PE=1 SV=2" "0.000" "False" "65.436" "25" "15" "22" "15" "772" "83.4" "7.20" "80.03" "15" "cell-cell signaling;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf03920" "7090" "ENSG00000140332" "TLE3" "B4DPT0; E9PD64; F8W964; hsa:7090; Q04726; Q6PI57; Q8IVV6; Q8WVR2; Q9HCM5" "White fat cell differentiation" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Estrogen-dependent gene expression; Repression of WNT target genes" "5" "0" "1.023" "0.924" "0.958" "1.024" "0.939" "0.984" "0.970" "0.978" "0.993" "1783.4" "1825.0" "1648.4" "1707.7" "1826.7" "1673.9" "1755.5" "1729.4" "1743.5" "1770.2" "" "" "" "" "" "" "" "" "" "" "1603.5" "1476.7" "1491.0" "1666.9" "1507.4" "1673.9" "1314.4" "1527.5" "1560.1" "631.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3854455294821174963" "False" "High" "IsMasterProtein" "Q969X6" "U3 small nucleolar RNA-associated protein 4 homolog OS=Homo sapiens OX=9606 GN=UTP4 PE=1 SV=1" "0.000" "False" "65.395" "26" "16" "24" "16" "686" "76.8" "8.85" "95.48" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "84916" "ENSG00000141076; ENSG00000262788" "UTP4" "hsa:84916; Q8NCD9; Q8TF14; Q969X6; Q96SP0; Q96SR9; Q96SZ9; Q96T13; Q9BWK6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.072" "1.293" "0.918" "1.091" "1.358" "0.950" "1.052" "1.312" "0.609" "1810.8" "1941.1" "2341.7" "1662.0" "1975.6" "2459.0" "1721.2" "1905.7" "2376.5" "1102.4" "" "" "" "" "" "" "" "" "" "" "1628.1" "1570.7" "2118.2" "1622.3" "1630.3" "2459.0" "1288.8" "1683.3" "2126.5" "393.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2043411241930693309" "False" "High" "IsMasterProtein" "Q96JM3" "Chromosome alignment-maintaining phosphoprotein 1 OS=Homo sapiens OX=9606 GN=CHAMP1 PE=1 SV=2" "0.000" "False" "65.388" "24" "17" "19" "17" "812" "89.0" "8.44" "73.42" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "" "283489" "ENSG00000198824" "CHAMP1" "B3KU06; hsa:283489; Q6P181; Q8NC88; Q96JM3; Q9BST0" "" "" "0" "0" "0.937" "0.900" "1.001" "1.020" "1.006" "1.060" "0.945" "0.906" "2.129" "1689.2" "1583.1" "1520.6" "1691.3" "1722.9" "1699.5" "1790.0" "1597.1" "1529.6" "3595.5" "" "" "" "" "" "" "" "" "" "" "1518.7" "1281.0" "1375.4" "1651.0" "1421.7" "1699.5" "1340.3" "1410.6" "1368.7" "1283.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5656635003875974689" "False" "High" "IsMasterProtein" "Q13111" "Chromatin assembly factor 1 subunit A OS=Homo sapiens OX=9606 GN=CHAF1A PE=1 SV=3" "0.000" "False" "65.311" "20" "15" "22" "15" "956" "106.8" "5.94" "76.04" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf11600, Pf12253, Pf15539, Pf15557" "10036" "ENSG00000167670" "CHAF1A" "hsa:10036; Q13111; Q6NXG5; Q7Z7K3; Q9UJY8" "Nanoparticle triggered autophagic cell death" "" "1" "0" "1.126" "1.115" "1.006" "1.121" "1.213" "1.069" "1.085" "1.188" "1.965" "1838.3" "2070.8" "2049.6" "1850.1" "2061.5" "2229.7" "1964.3" "1995.1" "2183.6" "3612.4" "" "" "" "" "" "" "" "" "" "" "1652.8" "1675.6" "1853.9" "1806.0" "1701.2" "2229.7" "1470.8" "1762.2" "1953.9" "1289.5" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8845776874603627941" "False" "High" "IsMasterProtein" "Q92930" "Ras-related protein Rab-8B OS=Homo sapiens OX=9606 GN=RAB8B PE=1 SV=2" "0.000" "False" "65.159" "53" "11" "41" "3" "207" "23.6" "9.07" "137.80" "11" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00071" "51762" "ENSG00000166128" "RAB8B" "hsa:51762; Q5JPC4; Q92930; Q9P293" "Ectoderm differentiation; Ectoderm differentiation" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TBC/RABGAPs" "5" "0" "0.960" "1.043" "1.010" "1.041" "1.185" "0.989" "0.975" "1.068" "0.726" "508.6" "488.2" "530.4" "513.8" "529.4" "602.9" "503.2" "495.9" "543.3" "369.3" "" "" "" "" "" "" "" "" "" "" "457.3" "395.1" "479.7" "501.5" "436.9" "602.9" "376.8" "438.0" "486.1" "131.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2447510198658431817" "False" "High" "IsMasterProtein" "Q9H910" "Jupiter microtubule associated homolog 2 OS=Homo sapiens OX=9606 GN=JPT2 PE=1 SV=1" "0.000" "False" "65.153" "70" "10" "32" "10" "190" "20.1" "9.26" "106.66" "10" "transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf17054" "90861" "ENSG00000206053" "JPT2" "B1AJY2; B4DLH4; hsa:90861; Q6EIC7; Q9H910" "" "" "0" "0" "1.008" "0.973" "1.007" "0.985" "0.997" "0.949" "1.038" "0.947" "0.816" "1995.5" "2012.1" "1941.5" "2009.8" "1965.0" "1990.4" "1894.0" "2072.2" "1890.6" "1628.3" "" "" "" "" "" "" "" "" "" "" "1794.2" "1628.1" "1756.2" "1961.9" "1621.6" "1990.4" "1418.2" "1830.3" "1691.7" "581.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1983440514863483257" "False" "High" "IsMasterProtein" "O15523" "ATP-dependent RNA helicase DDX3Y OS=Homo sapiens OX=9606 GN=DDX3Y PE=1 SV=2" "0.000" "False" "65.138" "25" "14" "25" "1" "660" "73.1" "7.55" "89.52" "14" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "8653" "ENSG00000067048" "DDX3Y" "B4DK29; B4DXX7; hsa:8653; O15523; Q8IYV7" "Novel intracellular components of RIG-I-like receptor pathway" "" "1" "0" "0.956" "0.881" "1.010" "1.042" "0.883" "1.061" "1.034" "0.911" "1.572" "64.7" "61.9" "57.0" "65.4" "67.5" "57.2" "68.7" "66.9" "59.0" "101.7" "" "" "" "" "" "" "" "" "" "" "58.2" "50.1" "51.6" "63.8" "55.7" "57.2" "51.4" "59.1" "52.8" "36.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650974207865814862" "False" "High" "IsMasterProtein" "P04818" "Thymidylate synthase OS=Homo sapiens OX=9606 GN=TYMS PE=1 SV=3" "0.000" "False" "65.134" "37" "10" "23" "10" "313" "35.7" "7.01" "97.28" "10" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00303" "7298" "ENSG00000176890" "TYMS" "hsa:7298; P04818; Q8WYK3; Q8WYK4" "Fluoropyrimidine activity; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates; G1/S-Specific Transcription" "9" "0" "0.975" "1.070" "0.988" "0.958" "1.087" "1.014" "0.952" "1.085" "1.437" "1511.4" "1473.4" "1616.7" "1494.1" "1448.2" "1643.1" "1533.3" "1438.2" "1639.7" "2171.4" "" "" "" "" "" "" "" "" "" "" "1358.9" "1192.2" "1462.4" "1458.4" "1195.0" "1643.1" "1148.1" "1270.3" "1467.2" "775.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-997186877852076993" "False" "High" "IsMasterProtein" "Q9NYL9" "Tropomodulin-3 OS=Homo sapiens OX=9606 GN=TMOD3 PE=1 SV=1" "0.000" "False" "65.050" "47" "14" "21" "14" "352" "39.6" "5.19" "82.45" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton" "cytoskeletal activity" "Pf03250" "29766" "ENSG00000138594" "TMOD3" "B2R6G7; hsa:29766; Q9NT43; Q9NYL9; Q9NZR0" "VEGFA-VEGFR2 signaling" "RND3 GTPase cycle; Striated Muscle Contraction; RHOBTB2 GTPase cycle" "4" "0" "0.897" "1.024" "0.972" "0.971" "1.011" "1.038" "0.960" "1.027" "1.295" "1285.2" "1153.2" "1316.1" "1249.6" "1247.6" "1299.2" "1334.1" "1234.0" "1320.5" "1665.0" "" "" "" "" "" "" "" "" "" "" "1155.6" "933.1" "1190.5" "1219.7" "1029.5" "1299.2" "998.9" "1089.9" "1181.6" "594.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857038607970442570" "False" "High" "IsMasterProtein" "Q16836" "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HADH PE=1 SV=3" "0.000" "False" "65.042" "51" "14" "30" "14" "314" "34.3" "8.85" "94.56" "14" "other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00725, Pf02737" "3033" "ENSG00000138796" "HADH" "hsa:3033; J3KQ17; O00324; O00397; O00753; Q16836; Q4W5B4" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; Amino acid metabolism; IL-18 signaling pathway; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA; Beta oxidation of octanoyl-CoA to hexanoyl-CoA; Beta oxidation of hexanoyl-CoA to butanoyl-CoA; Beta oxidation of butanoyl-CoA to acetyl-CoA; Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA" "12" "0" "0.950" "0.925" "1.053" "0.961" "0.944" "0.922" "0.996" "0.963" "0.758" "2791.1" "2651.8" "2581.7" "2939.9" "2682.4" "2634.7" "2573.2" "2780.4" "2688.3" "2116.2" "" "" "" "" "" "" "" "" "" "" "2509.5" "2145.7" "2335.2" "2869.7" "2213.6" "2634.7" "1926.7" "2455.9" "2405.5" "755.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7059158695698353069" "False" "High" "IsMasterProtein" "Q9H0U4" "Ras-related protein Rab-1B OS=Homo sapiens OX=9606 GN=RAB1B PE=1 SV=1" "0.000" "False" "64.995" "69" "12" "40" "4" "201" "22.2" "5.73" "144.94" "12" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "81876" "ENSG00000174903" "RAB1B" "A8K7S1; hsa:81876; Q9H0U4" "" "COPII-mediated vesicle transport; COPI-mediated anterograde transport; COPI-dependent Golgi-to-ER retrograde traffic; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Golgi Cisternae Pericentriolar Stack Reorganization" "6" "0" "1.005" "0.986" "0.929" "0.994" "0.974" "0.958" "0.976" "1.039" "0.835" "1126.6" "1132.6" "1110.4" "1046.1" "1119.4" "1097.9" "1078.8" "1100.0" "1170.2" "940.4" "" "" "" "" "" "" "" "" "" "" "1013.0" "916.5" "1004.4" "1021.1" "923.8" "1097.9" "807.8" "971.6" "1047.1" "335.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137976061761612537" "False" "High" "IsMasterProtein" "Q16512" "Serine/threonine-protein kinase N1 OS=Homo sapiens OX=9606 GN=PKN1 PE=1 SV=2" "0.000" "False" "64.900" "20" "16" "21" "14" "942" "103.9" "6.37" "84.87" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5585" "ENSG00000123143" "PKN1" "A8K7W5; B2R9R4; B3KVN3; hsa:5585; Q15143; Q16512; Q504U4; Q8IUV5; Q9UD44" "Apoptosis-related network due to altered Notch3 in ovarian cancer; PI3K-Akt signaling pathway; IL-18 signaling pathway; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3" "10" "1" "1.032" "0.992" "0.987" "1.027" "0.967" "1.065" "0.997" "0.955" "1.229" "1805.1" "1863.1" "1790.2" "1782.4" "1854.0" "1746.0" "1922.0" "1798.9" "1724.6" "2217.6" "" "" "" "" "" "" "" "" "" "" "1623.0" "1507.5" "1619.3" "1739.8" "1529.9" "1746.0" "1439.2" "1588.9" "1543.2" "791.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1849398190907063362" "False" "High" "IsMasterProtein" "P35813" "Protein phosphatase 1A OS=Homo sapiens OX=9606 GN=PPM1A PE=1 SV=1" "0.000" "False" "64.874" "40" "12" "23" "10" "382" "42.4" "5.36" "85.80" "12" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf00481, Pf07830" "5494" "ENSG00000100614" "PPM1A" "B5BU11; hsa:5494; J3KNM0; O75551; P35813" "TGF-beta signaling pathway; MAPK signaling pathway" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Energy dependent regulation of mTOR by LKB1-AMPK" "4" "0" "0.948" "0.966" "0.929" "0.993" "0.911" "0.950" "0.947" "0.940" "0.861" "1530.7" "1450.4" "1479.4" "1422.1" "1520.0" "1395.0" "1454.6" "1448.9" "1438.5" "1317.2" "" "" "" "" "" "" "" "" "" "" "1376.2" "1173.6" "1338.2" "1388.1" "1254.3" "1395.0" "1089.2" "1279.7" "1287.1" "470.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1450891647387080638" "False" "High" "IsMasterProtein" "Q9BUL8" "Programmed cell death protein 10 OS=Homo sapiens OX=9606 GN=PDCD10 PE=1 SV=1" "0.000" "False" "64.804" "42" "8" "25" "8" "212" "24.7" "8.19" "104.71" "8" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06840, Pf20929" "11235" "ENSG00000114209" "PDCD10" "A8K515; D3DNN5; hsa:11235; O14811; Q9BUL8" "" "" "0" "0" "1.013" "1.058" "0.988" "1.075" "0.989" "1.052" "1.030" "1.072" "1.034" "2371.7" "2403.5" "2510.0" "2343.7" "2550.7" "2346.2" "2494.8" "2442.9" "2542.0" "2453.2" "" "" "" "" "" "" "" "" "" "" "2132.3" "1944.9" "2270.4" "2287.8" "2104.9" "2346.2" "1868.1" "2157.8" "2274.5" "875.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2214301499697937672" "False" "High" "IsMasterProtein" "Q96C86" "m7GpppX diphosphatase OS=Homo sapiens OX=9606 GN=DCPS PE=1 SV=2" "0.000" "False" "64.790" "39" "13" "31" "13" "337" "38.6" "6.38" "130.35" "13" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05652, Pf11969" "28960" "ENSG00000110063" "DCPS" "hsa:28960; Q8NHL8; Q96C86; Q9Y2S5" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.013" "1.019" "1.036" "1.052" "1.010" "1.021" "1.065" "1.050" "0.852" "2566.4" "2599.4" "2616.1" "2658.1" "2699.2" "2591.9" "2621.5" "2733.6" "2695.7" "2185.6" "" "" "" "" "" "" "" "" "" "" "2307.5" "2103.4" "2366.3" "2594.6" "2227.4" "2591.9" "1962.9" "2414.4" "2412.1" "780.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739284738644474323" "False" "High" "IsMasterProtein" "P25098" "Beta-adrenergic receptor kinase 1 OS=Homo sapiens OX=9606 GN=GRK2 PE=1 SV=2" "0.000" "False" "64.730" "29" "18" "23" "11" "689" "79.5" "7.28" "86.18" "18" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "156" "ENSG00000173020" "GRK2" "B0ZBE1; hsa:156; P25098; Q13837; Q6GTT3" "Chemokine signaling pathway; Hedgehog signaling pathway; Hedgehog signaling pathway; HDAC6 interactions in the central nervous system" "G alpha (s) signalling events; G alpha (q) signalling events; Activation of SMO; Cargo recognition for clathrin-mediated endocytosis; Calmodulin induced events" "9" "6" "1.023" "0.954" "0.991" "1.069" "0.984" "1.031" "1.007" "0.996" "0.860" "2104.2" "2151.6" "2007.9" "2086.1" "2249.0" "2070.2" "2170.3" "2119.0" "2095.9" "1808.5" "" "" "" "" "" "" "" "" "" "" "1891.8" "1741.0" "1816.2" "2036.3" "1855.9" "2070.2" "1625.1" "1871.7" "1875.4" "645.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5950667386624240413" "False" "High" "IsMasterProtein" "Q01082" "Spectrin beta chain, non-erythrocytic 1 OS=Homo sapiens OX=9606 GN=SPTBN1 PE=1 SV=2" "0.000" "False" "64.705" "9" "22" "23" "19" "2364" "274.4" "5.57" "75.37" "22" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00307, Pf00435" "6711" "ENSG00000115306" "SPTBN1" "B2RP63; hsa:6711; O60837; Q01082; Q16057; Q53R99; Q59ER3; Q8IX99" "TGF-beta signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; COPI-mediated anterograde transport; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; RAF/MAP kinase cascade; NCAM signaling for neurite out-growth; Interaction between L1 and Ankyrins; Signaling by FLT3 fusion proteins" "12" "0" "1.022" "1.027" "0.976" "1.066" "0.983" "0.991" "1.019" "0.988" "0.863" "1253.3" "1281.4" "1286.9" "1223.4" "1336.6" "1232.3" "1241.8" "1277.3" "1238.1" "1081.1" "" "" "" "" "" "" "" "" "" "" "1126.8" "1036.9" "1164.1" "1194.2" "1103.0" "1232.3" "929.8" "1128.2" "1107.9" "385.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5278147799990617038" "False" "High" "IsMasterProtein" "P78318" "Immunoglobulin-binding protein 1 OS=Homo sapiens OX=9606 GN=IGBP1 PE=1 SV=1" "0.000" "False" "64.698" "36" "11" "24" "11" "339" "39.2" "5.38" "98.27" "11" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf04177" "3476" "ENSG00000089289" "IGBP1" "P78318; Q8TAB2" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.007" "0.974" "0.973" "1.093" "0.977" "1.120" "1.032" "0.984" "0.937" "993.2" "1000.0" "967.1" "966.1" "1085.3" "970.2" "1112.6" "1024.7" "977.3" "930.4" "" "" "" "" "" "" "" "" "" "" "893.0" "809.2" "874.8" "943.0" "895.6" "970.2" "833.1" "905.1" "874.5" "332.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3069559242831628546" "False" "High" "IsMasterProtein" "Q7Z460" "CLIP-associating protein 1 OS=Homo sapiens OX=9606 GN=CLASP1 PE=1 SV=1" "0.000" "False" "64.663" "12" "17" "24" "11" "1538" "169.3" "9.03" "79.18" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf02985, Pf12348, Pf21040" "23332" "ENSG00000074054" "CLASP1" "A2RU21; B7ZLX3; F5GWS0; hsa:23332; O75118; Q2KHQ9; Q5H9P0; Q7Z460; Q8N5B8; Q9BQT5" "Microtubule cytoskeleton regulation; Splicing factor NOVA regulated synaptic proteins; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Role of ABL in ROBO-SLIT signaling" "17" "0" "1.004" "1.021" "1.022" "1.039" "1.013" "1.161" "0.935" "0.961" "2.537" "779.1" "782.5" "795.1" "795.9" "809.7" "789.1" "904.4" "728.5" "749.0" "1976.3" "" "" "" "" "" "" "" "" "" "" "700.5" "633.2" "719.2" "776.9" "668.2" "789.1" "677.2" "643.4" "670.2" "705.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8791134701989231462" "False" "High" "IsMasterProtein" "Q9UQ13" "Leucine-rich repeat protein SHOC-2 OS=Homo sapiens OX=9606 GN=SHOC2 PE=1 SV=2" "0.000" "False" "64.610" "24" "14" "21" "14" "582" "64.8" "8.46" "74.20" "14" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13855" "8036" "ENSG00000108061" "SHOC2" "A8K9W8; B3KR23; hsa:8036; O76063; Q5VZS8; Q5VZS9; Q9UQ13" "Ras signaling; 22q11.2 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling" "6" "0" "1.061" "1.035" "1.016" "1.090" "1.054" "1.103" "1.084" "1.090" "0.930" "1796.7" "1906.9" "1860.0" "1826.2" "1959.2" "1894.0" "1981.6" "1948.2" "1958.1" "1671.1" "" "" "" "" "" "" "" "" "" "" "1615.4" "1543.0" "1682.4" "1782.6" "1616.8" "1894.0" "1483.8" "1720.8" "1752.1" "596.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2739049111137792080" "False" "High" "IsMasterProtein" "P13861" "cAMP-dependent protein kinase type II-alpha regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR2A PE=1 SV=2" "0.000" "False" "64.599" "51" "16" "20" "16" "404" "45.5" "5.07" "83.17" "16" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5576" "ENSG00000114302" "PRKAR2A" "hsa:5576; P13861; Q16823; Q9BUB1" "Myometrial relaxation and contraction pathways; G protein signaling pathways; TGF-beta signaling pathway; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GDNF signaling; Calcium regulation in cardiac cells; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5" "22" "0" "1.048" "1.073" "1.003" "1.031" "1.049" "1.117" "1.014" "1.026" "0.960" "1098.5" "1150.9" "1178.4" "1101.9" "1132.5" "1152.6" "1227.0" "1113.7" "1126.6" "1054.4" "" "" "" "" "" "" "" "" "" "" "987.7" "931.3" "1065.9" "1075.6" "934.6" "1152.6" "918.7" "983.7" "1008.1" "376.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4633912985078584352" "False" "High" "IsMasterProtein" "P07948" "Tyrosine-protein kinase Lyn OS=Homo sapiens OX=9606 GN=LYN PE=1 SV=3" "0.000" "False" "64.591" "34" "15" "27" "12" "512" "58.5" "7.11" "90.60" "15" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "4067" "ENSG00000254087" "LYN" "A0AVQ5; hsa:4067; P07948" "IL-5 signaling pathway; RANKL/RANK signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; GDNF signaling" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; EPHB-mediated forward signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; EPH-ephrin mediated repulsion of cells; EPHA-mediated growth cone collapse; Signaling by CSF1 (M-CSF) in myeloid cells; CD28 co-stimulation; PECAM1 interactions; CTLA4 inhibitory signaling; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; Cyclin D associated events in G1; Growth hormone receptor signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Erythropoietin activates STAT5; Erythropoietin activates RAS; Platelet Adhesion to exposed collagen; CD209 (DC-SIGN) signaling; Dectin-2 family" "45" "1" "0.992" "0.950" "1.023" "0.972" "0.968" "1.069" "0.976" "1.031" "0.785" "1545.9" "1533.0" "1468.4" "1580.9" "1502.5" "1496.1" "1653.1" "1508.9" "1594.1" "1213.5" "" "" "" "" "" "" "" "" "" "" "1389.9" "1240.5" "1328.2" "1543.2" "1239.9" "1496.1" "1237.8" "1332.7" "1426.4" "433.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697367026041443041" "False" "High" "IsMasterProtein" "Q96A49" "Synapse-associated protein 1 OS=Homo sapiens OX=9606 GN=SYAP1 PE=1 SV=1" "0.000" "False" "64.581" "36" "12" "23" "12" "352" "39.9" "4.53" "102.63" "12" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf03909" "94056" "ENSG00000169895" "SYAP1" "hsa:94056; Q68CP1; Q96A49; Q96C60; Q96JQ6; Q96T20" "" "" "0" "0" "0.943" "0.954" "0.987" "0.995" "0.964" "0.979" "1.024" "0.986" "0.862" "2534.4" "2389.7" "2418.7" "2502.1" "2522.4" "2442.5" "2482.0" "2596.1" "2498.1" "2184.1" "" "" "" "" "" "" "" "" "" "" "2278.7" "1933.6" "2187.8" "2442.4" "2081.5" "2442.5" "1858.5" "2293.1" "2235.3" "779.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8995832376771225777" "False" "High" "IsMasterProtein" "Q9UBS4" "DnaJ homolog subfamily B member 11 OS=Homo sapiens OX=9606 GN=DNAJB11 PE=1 SV=1" "0.000" "False" "64.575" "35" "11" "17" "11" "358" "40.5" "6.18" "77.85" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00226, Pf01556" "51726" "ENSG00000090520" "DNAJB11" "hsa:51726; Q542Y5; Q542Y9; Q6IAQ8; Q96JC6; Q9UBS4" "Photodynamic therapy-induced unfolded protein response" "XBP1(S) activates chaperone genes" "2" "0" "0.959" "1.061" "0.970" "1.000" "1.027" "0.987" "1.013" "1.076" "0.836" "1657.1" "1588.8" "1759.0" "1606.6" "1657.2" "1701.3" "1634.8" "1679.3" "1782.4" "1386.1" "" "" "" "" "" "" "" "" "" "" "1489.9" "1285.6" "1591.0" "1568.3" "1367.6" "1701.3" "1224.1" "1483.2" "1594.9" "494.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518810540954697302" "False" "High" "IsMasterProtein" "Q8TAT6" "Nuclear protein localization protein 4 homolog OS=Homo sapiens OX=9606 GN=NPLOC4 PE=1 SV=3" "0.000" "False" "64.529" "30" "14" "21" "14" "608" "68.1" "6.38" "76.99" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf05020, Pf05021, Pf11543" "55666" "ENSG00000182446" "NPLOC4" "hsa:55666; Q8N3J1; Q8TAT6; Q9H8V2; Q9H964; Q9NWR5; Q9P229" "" "Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "3" "0" "1.048" "1.042" "1.018" "1.048" "1.060" "1.049" "1.017" "1.083" "0.964" "1795.7" "1881.7" "1871.3" "1827.2" "1882.4" "1903.7" "1883.2" "1826.3" "1943.8" "1730.8" "" "" "" "" "" "" "" "" "" "" "1614.5" "1522.6" "1692.6" "1783.6" "1553.4" "1903.7" "1410.1" "1613.1" "1739.3" "617.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3973865475325375053" "False" "High" "IsMasterProtein" "P15374" "Ubiquitin carboxyl-terminal hydrolase isozyme L3 OS=Homo sapiens OX=9606 GN=UCHL3 PE=1 SV=1" "0.000" "False" "64.437" "63" "11" "29" "11" "230" "26.2" "4.92" "116.30" "11" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01088" "7347" "ENSG00000118939" "UCHL3" "B2R970; hsa:7347; P15374; Q5TBK8; Q6IBE9" "Proteasome degradation" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; UCH proteinases; Neddylation" "4" "0" "0.977" "0.948" "1.017" "1.036" "0.993" "1.033" "1.023" "0.979" "0.820" "2847.6" "2782.1" "2698.4" "2896.7" "2949.1" "2827.7" "2940.7" "2913.3" "2786.7" "2334.6" "" "" "" "" "" "" "" "" "" "" "2560.2" "2251.2" "2440.8" "2827.6" "2433.6" "2827.7" "2201.9" "2573.3" "2493.5" "833.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4424001123554839232" "False" "High" "IsMasterProtein" "Q96CW1" "AP-2 complex subunit mu OS=Homo sapiens OX=9606 GN=AP2M1 PE=1 SV=2" "0.000" "False" "64.372" "41" "17" "23" "17" "435" "49.6" "9.54" "91.59" "17" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00928, Pf01217" "1173" "ENSG00000161203" "AP2M1" "A6NE12; D3DNT1; hsa:1173; P20172; P53679; Q96CW1" "Synaptic vesicle pathway; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome; GDNF signaling" "Potential therapeutics for SARS; Recycling pathway of L1; MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Nef mediated downregulation of CD28 cell surface expression; Formation of annular gap junctions" "21" "0" "1.078" "1.075" "0.995" "1.096" "0.999" "1.032" "0.996" "1.099" "0.891" "2040.5" "2199.9" "2193.7" "2030.3" "2235.5" "2038.3" "2106.5" "2033.0" "2241.8" "1818.2" "" "" "" "" "" "" "" "" "" "" "1834.6" "1780.0" "1984.3" "1981.9" "1844.8" "2038.3" "1577.3" "1795.7" "2005.9" "649.1" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3988284594388072596" "False" "High" "IsMasterProtein" "Q92974" "Rho guanine nucleotide exchange factor 2 OS=Homo sapiens OX=9606 GN=ARHGEF2 PE=1 SV=4" "0.000" "False" "64.352" "20" "20" "28" "20" "986" "111.5" "7.27" "89.93" "20" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00621, Pf17838" "9181" "ENSG00000116584" "ARHGEF2" "D3DVA6; hsa:9181; O75142; Q15079; Q5VY92; Q8TDA3; Q8WUG4; Q92974; Q9H023" "Pathogenic Escherichia coli infection" "RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "5" "0" "1.021" "1.026" "1.004" "1.018" "1.063" "1.082" "0.946" "1.093" "4.063" "1758.4" "1795.7" "1803.9" "1765.4" "1790.7" "1869.7" "1902.8" "1663.8" "1922.7" "7144.2" "" "" "" "" "" "" "" "" "" "" "1581.0" "1453.0" "1631.7" "1723.3" "1477.8" "1869.7" "1424.8" "1469.6" "1720.4" "2550.3" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4157182932771800811" "False" "High" "IsMasterProtein" "Q07955" "Serine/arginine-rich splicing factor 1 OS=Homo sapiens OX=9606 GN=SRSF1 PE=1 SV=2" "0.000" "False" "64.343" "43" "11" "40" "11" "248" "27.7" "10.36" "136.76" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6426" "ENSG00000136450" "SRSF1" "B2R6Z7; D3DTZ3; hsa:6426; Q07955; Q13809" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "0.985" "0.944" "1.015" "0.996" "0.958" "0.938" "0.981" "0.927" "0.835" "3378.1" "3328.2" "3190.1" "3428.5" "3363.0" "3237.5" "3168.9" "3312.7" "3131.3" "2819.3" "" "" "" "" "" "" "" "" "" "" "3037.2" "2693.0" "2885.5" "3346.7" "2775.2" "3237.5" "2372.8" "2926.0" "2801.8" "1006.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6205796797264401430" "False" "High" "IsMasterProtein" "Q96DH6" "RNA-binding protein Musashi homolog 2 OS=Homo sapiens OX=9606 GN=MSI2 PE=1 SV=1" "0.000" "False" "64.291" "31" "8" "26" "8" "328" "35.2" "8.48" "96.61" "8" "developmental processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "124540" "ENSG00000153944" "MSI2" "hsa:124540; Q7Z6M7; Q8N9T4; Q96DH6" "" "RHOBTB2 GTPase cycle" "1" "0" "0.986" "0.980" "0.995" "1.024" "0.969" "1.034" "1.037" "0.994" "0.899" "2010.4" "1981.9" "1970.3" "1999.7" "2059.2" "1948.1" "2079.0" "2085.1" "1998.0" "1807.5" "" "" "" "" "" "" "" "" "" "" "1807.6" "1603.7" "1782.2" "1952.0" "1699.3" "1948.1" "1556.7" "1841.7" "1787.8" "645.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-525798378457225330" "False" "High" "IsMasterProtein" "P0CG39" "POTE ankyrin domain family member J OS=Homo sapiens OX=9606 GN=POTEJ PE=1 SV=1" "0.000" "False" "64.252" "11" "10" "157" "3" "1038" "117.3" "5.97" "490.26" "10" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "653781" "ENSG00000222038" "POTEJ" "hsa:653781; P0CG39" "" "" "0" "0" "1.034" "1.004" "1.045" "1.048" "1.014" "1.142" "1.046" "1.064" "0.895" "697.8" "721.3" "700.2" "729.3" "731.6" "707.4" "797.1" "730.1" "742.6" "624.6" "" "" "" "" "" "" "" "" "" "" "627.4" "583.6" "633.4" "711.9" "603.7" "707.4" "596.8" "644.9" "664.5" "223.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2595781739747339031" "False" "High" "IsMasterProtein" "Q14677" "Clathrin interactor 1 OS=Homo sapiens OX=9606 GN=CLINT1 PE=1 SV=1" "0.000" "False" "64.216" "28" "16" "24" "16" "625" "68.2" "6.42" "90.60" "16" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01417" "9685" "ENSG00000113282" "CLINT1" "B7Z6F8; D3DQJ6; hsa:9685; Q14677; Q8NAF1; Q96E05" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.973" "0.991" "1.041" "1.047" "1.024" "1.083" "1.012" "1.036" "0.920" "2191.1" "2132.1" "2172.1" "2280.4" "2293.0" "2243.1" "2372.9" "2216.6" "2270.0" "2015.2" "" "" "" "" "" "" "" "" "" "" "1970.0" "1725.2" "1964.7" "2226.0" "1892.2" "2243.1" "1776.7" "1957.8" "2031.2" "719.4" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8737911317243548471" "False" "High" "IsMasterProtein" "Q15631" "Translin OS=Homo sapiens OX=9606 GN=TSN PE=1 SV=1" "0.000" "False" "64.201" "48" "14" "28" "14" "228" "26.2" "6.44" "111.70" "14" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01997" "7247" "ENSG00000211460" "TSN" "B7Z3X8; hsa:7247; Q15631; Q5U0K7" "" "Small interfering RNA (siRNA) biogenesis" "1" "0" "1.073" "1.118" "1.105" "1.078" "1.051" "1.097" "1.044" "1.155" "0.906" "1933.8" "2074.5" "2162.3" "2136.7" "2085.5" "2033.0" "2121.9" "2019.5" "2233.4" "1751.7" "" "" "" "" "" "" "" "" "" "" "1738.7" "1678.6" "1955.9" "2085.7" "1721.0" "2033.0" "1588.9" "1783.7" "1998.5" "625.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5815926444524445653" "False" "High" "IsMasterProtein" "Q7Z406" "Myosin-14 OS=Homo sapiens OX=9606 GN=MYH14 PE=1 SV=2" "0.000" "False" "64.142" "5" "13" "31" "1" "1995" "227.7" "5.60" "109.71" "13" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf01576, Pf02736" "79784" "ENSG00000105357" "MYH14" "B0I1S2; C3TTN4; hsa:79784; Q5CZ75; Q6XYE4; Q76B62; Q7Z406; Q8WV23; Q96I22; Q9BT27; Q9BW35; Q9H882" "" "EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate CIT; RHO GTPases activate PKNs; RHO GTPases activate PAKs" "6" "0" "1.056" "1.581" "1.045" "1.186" "1.389" "0.879" "0.885" "1.507" "1.170" "73.3" "77.4" "115.8" "76.6" "86.9" "101.8" "64.4" "64.9" "110.4" "85.7" "" "" "" "" "" "" "" "" "" "" "65.9" "62.6" "104.8" "74.8" "71.7" "101.8" "48.2" "57.3" "98.8" "30.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4231086194268643311" "False" "High" "IsMasterProtein" "Q8N6R0" "eEF1A lysine and N-terminal methyltransferase OS=Homo sapiens OX=9606 GN=METTL13 PE=1 SV=1" "0.000" "False" "64.114" "24" "14" "21" "14" "699" "78.7" "6.73" "81.41" "14" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01564, Pf13847" "51603" "ENSG00000010165" "METTL13" "A6NFK0; A8K6S5; hsa:51603; O94940; Q53EZ6; Q5TGP9; Q5TGQ0; Q8N2P8; Q8N6R0; Q96J11; Q96SQ0; Q9Y2Z1; Q9Y3M6" "" "" "0" "0" "0.983" "1.075" "1.032" "1.048" "1.024" "1.108" "0.980" "1.015" "1.310" "1035.5" "1017.7" "1112.7" "1068.4" "1085.7" "1060.2" "1147.5" "1015.2" "1051.3" "1356.2" "" "" "" "" "" "" "" "" "" "" "931.1" "823.5" "1006.5" "1042.9" "895.9" "1060.2" "859.3" "896.7" "940.7" "484.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5620722506811584939" "False" "High" "IsMasterProtein" "Q96GG9" "DCN1-like protein 1 OS=Homo sapiens OX=9606 GN=DCUN1D1 PE=1 SV=1" "0.000" "False" "64.040" "38" "11" "30" "11" "259" "30.1" "5.34" "105.44" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03556, Pf14555" "54165" "ENSG00000043093" "DCUN1D1" "B2RB37; hsa:54165; Q7L3G9; Q8TEX7; Q96GG9; Q9H6M1; Q9HCT3" "" "Neddylation" "1" "0" "1.015" "1.060" "1.014" "0.992" "1.043" "0.986" "1.061" "0.987" "0.802" "2680.5" "2721.0" "2840.8" "2718.7" "2659.9" "2796.9" "2642.5" "2843.9" "2646.8" "2150.0" "" "" "" "" "" "" "" "" "" "" "2410.0" "2201.7" "2569.6" "2653.8" "2195.0" "2796.9" "1978.6" "2511.9" "2368.3" "767.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008482199911470815" "False" "High" "IsMasterProtein" "O43516" "WAS/WASL-interacting protein family member 1 OS=Homo sapiens OX=9606 GN=WIPF1 PE=1 SV=3" "0.000" "False" "63.990" "36" "14" "30" "14" "503" "51.2" "11.47" "112.07" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "7456" "ENSG00000115935" "WIPF1" "B8ZZM1; D3DPE4; hsa:7456; O43516; Q15220; Q53TA9; Q6MZU9; Q9BU37; Q9UNP1" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs" "5" "0" "0.970" "0.952" "0.935" "1.007" "0.924" "0.984" "0.973" "0.922" "0.781" "1595.1" "1547.5" "1519.3" "1491.0" "1606.4" "1473.3" "1570.1" "1552.0" "1471.0" "1246.4" "" "" "" "" "" "" "" "" "" "" "1434.2" "1252.2" "1374.3" "1455.4" "1325.6" "1473.3" "1175.7" "1370.8" "1316.2" "444.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6094529598036827804" "False" "High" "IsMasterProtein" "Q13442" "28 kDa heat- and acid-stable phosphoprotein OS=Homo sapiens OX=9606 GN=PDAP1 PE=1 SV=1" "0.000" "False" "63.981" "55" "12" "31" "12" "181" "20.6" "8.87" "114.38" "12" "signal transduction" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf10252" "11333" "ENSG00000106244" "PDAP1" "D6W5S5; hsa:11333; Q13442; Q92906" "" "Neutrophil degranulation" "1" "0" "1.040" "0.953" "0.973" "0.959" "0.995" "1.045" "1.048" "0.887" "0.681" "4209.1" "4379.4" "4012.5" "4094.6" "4035.0" "4190.1" "4398.3" "4410.6" "3734.5" "2865.2" "" "" "" "" "" "" "" "" "" "" "3784.4" "3543.7" "3629.4" "3996.9" "3329.8" "4190.1" "3293.3" "3895.7" "3341.6" "1022.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2222501069186758979" "False" "High" "IsMasterProtein" "Q86W42" "THO complex subunit 6 homolog OS=Homo sapiens OX=9606 GN=THOC6 PE=1 SV=1" "0.000" "False" "63.844" "55" "13" "18" "13" "341" "37.5" "7.43" "73.78" "13" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400" "79228" "ENSG00000131652" "THOC6" "B2RA85; hsa:79228; Q86W42; Q8NBR1; Q9BTV9" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.062" "1.009" "1.025" "1.052" "1.020" "1.011" "1.021" "1.014" "0.795" "1205.0" "1279.4" "1215.4" "1235.6" "1267.7" "1229.5" "1218.3" "1230.8" "1222.4" "957.9" "" "" "" "" "" "" "" "" "" "" "1083.4" "1035.2" "1099.3" "1206.1" "1046.1" "1229.5" "912.2" "1087.1" "1093.8" "342.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6054246856873050357" "False" "High" "IsMasterProtein" "Q15118" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDK1 PE=1 SV=1" "0.000" "False" "63.838" "36" "12" "17" "11" "436" "49.2" "8.81" "70.81" "12" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf02518, Pf10436" "5163" "ENSG00000152256" "PDK1" "B2R6T1; B7Z937; D3DPD8; E9PD65; hsa:5163; Q15118; Q308M4" "T cell receptor and co-stimulatory signaling; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Hereditary leiomyomatosis and renal cell carcinoma pathway; Non-small cell lung cancer; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Aspirin and miRNAs; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; TCA cycle in senescence; Pleural mesothelioma; Orexin receptor pathway; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Glucose metabolism in triple-negative breast cancer cells; GNAQ pathways in port-wine stain; EPO receptor signaling; DNA damage response (only ATM dependent)" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Mitochondrial protein degradation" "23" "1" "1.038" "0.999" "0.920" "1.013" "0.904" "1.071" "1.014" "0.951" "0.873" "1243.8" "1291.0" "1242.4" "1144.5" "1259.5" "1124.8" "1332.2" "1261.3" "1183.2" "1086.0" "" "" "" "" "" "" "" "" "" "" "1118.3" "1044.7" "1123.8" "1117.2" "1039.4" "1124.8" "997.5" "1114.1" "1058.7" "387.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3959098677357932626" "False" "High" "IsMasterProtein" "O43747" "AP-1 complex subunit gamma-1 OS=Homo sapiens OX=9606 GN=AP1G1 PE=1 SV=5" "0.000" "False" "63.808" "22" "19" "31" "19" "822" "91.3" "6.80" "102.17" "19" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf01602, Pf02883" "164" "ENSG00000166747" "AP1G1" "hsa:164; O43747; O75709; O75842; Q9UG09; Q9Y3U4" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.029" "0.990" "1.087" "1.017" "1.017" "0.962" "0.979" "1.068" "1.278" "1696.8" "1746.3" "1680.1" "1845.0" "1725.9" "1725.5" "1633.1" "1660.4" "1812.8" "2168.3" "" "" "" "" "" "" "" "" "" "" "1525.6" "1413.1" "1519.7" "1801.0" "1424.3" "1725.5" "1222.8" "1466.6" "1622.1" "774.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8476150003951297336" "False" "High" "IsMasterProtein" "Q96KG9" "N-terminal kinase-like protein OS=Homo sapiens OX=9606 GN=SCYL1 PE=1 SV=1" "0.000" "False" "63.620" "19" "14" "24" "14" "808" "89.6" "6.30" "89.29" "14" "stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "57410" "ENSG00000142186" "SCYL1" "A6NJF1; hsa:57410; Q96G50; Q96KG8; Q96KG9; Q96KH1; Q9HAW5; Q9HBL3; Q9NR53" "" "" "0" "0" "1.076" "1.102" "1.009" "1.071" "1.054" "1.044" "1.039" "1.084" "1.035" "1785.3" "1921.5" "1967.2" "1800.7" "1911.7" "1880.9" "1863.3" "1855.7" "1935.5" "1848.2" "" "" "" "" "" "" "" "" "" "" "1605.1" "1554.8" "1779.4" "1757.8" "1577.6" "1880.9" "1395.2" "1639.1" "1731.9" "659.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5150422290065042412" "False" "High" "IsMasterProtein" "Q9BXL5" "Hemogen OS=Homo sapiens OX=9606 GN=HEMGN PE=1 SV=1" "0.000" "False" "63.619" "35" "15" "30" "15" "484" "55.3" "4.87" "104.01" "15" "other biological processes" "nucleus" "" "" "55363" "ENSG00000136929" "HEMGN" "hsa:55363; Q6XAR3; Q86XY5; Q9BXL5; Q9NPC0" "" "" "0" "0" "1.038" "0.962" "1.020" "1.029" "1.001" "1.001" "1.057" "0.987" "0.899" "2144.6" "2225.3" "2062.2" "2188.5" "2206.9" "2147.7" "2147.6" "2266.2" "2116.6" "1929.0" "" "" "" "" "" "" "" "" "" "" "1928.2" "1800.7" "1865.3" "2136.3" "1821.2" "2147.7" "1608.0" "2001.7" "1893.9" "688.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8469309847663247920" "False" "High" "IsMasterProtein" "Q9UEY8" "Gamma-adducin OS=Homo sapiens OX=9606 GN=ADD3 PE=1 SV=1" "0.000" "False" "63.558" "23" "14" "19" "14" "706" "79.1" "6.32" "74.12" "14" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00596" "120" "ENSG00000148700" "ADD3" "D3DRA8; hsa:120; O43243; Q5VU09; Q92773; Q9UEY7; Q9UEY8" "" "Miscellaneous transport and binding events; RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "0.984" "1.029" "0.988" "1.019" "0.966" "1.042" "0.988" "0.987" "0.880" "1656.5" "1630.6" "1705.0" "1636.5" "1687.2" "1600.1" "1725.7" "1637.4" "1635.7" "1458.1" "" "" "" "" "" "" "" "" "" "" "1489.4" "1319.5" "1542.2" "1597.5" "1392.3" "1600.1" "1292.1" "1446.3" "1463.6" "520.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2127950675318566661" "False" "High" "IsMasterProtein" "Q9UJA5" "tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Homo sapiens OX=9606 GN=TRMT6 PE=1 SV=1" "0.000" "False" "63.539" "31" "16" "24" "16" "497" "55.8" "7.55" "86.17" "16" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf04189" "51605" "ENSG00000089195" "TRMT6" "B4DUV6; hsa:51605; Q76P92; Q9BQV5; Q9UJA5; Q9ULR7; Q9Y2Z8" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.027" "0.959" "0.982" "1.002" "0.977" "1.061" "0.981" "0.981" "0.817" "1468.5" "1508.4" "1407.9" "1441.9" "1471.8" "1434.8" "1557.7" "1440.5" "1440.4" "1199.0" "" "" "" "" "" "" "" "" "" "" "1320.3" "1220.5" "1273.5" "1407.5" "1214.6" "1434.8" "1166.4" "1272.3" "1288.9" "428.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3301543360737881129" "False" "High" "IsMasterProtein" "Q9Y281" "Cofilin-2 OS=Homo sapiens OX=9606 GN=CFL2 PE=1 SV=1" "0.000" "False" "63.524" "68" "12" "45" "6" "166" "18.7" "7.88" "146.49" "12" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00241" "1073" "ENSG00000165410" "CFL2" "G3V5P4; hsa:1073; Q9Y281" "Leptin signaling pathway; Microtubule cytoskeleton regulation; Regulation of actin cytoskeleton; G13 signaling pathway" "" "4" "0" "0.979" "0.865" "0.965" "0.961" "0.857" "0.932" "0.979" "0.926" "0.815" "366.4" "358.8" "316.8" "353.5" "352.2" "314.0" "341.4" "358.8" "339.3" "298.7" "" "" "" "" "" "" "" "" "" "" "329.5" "290.3" "286.6" "345.0" "290.6" "314.0" "255.6" "316.9" "303.6" "106.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7347727386660618652" "False" "High" "IsMasterProtein" "Q8IUI8" "Cytokine receptor-like factor 3 OS=Homo sapiens OX=9606 GN=CRLF3 PE=1 SV=2" "0.000" "False" "63.506" "27" "11" "22" "11" "442" "49.7" "5.14" "86.54" "11" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "51379" "ENSG00000176390" "CRLF3" "A6NJF3; B2R8C3; hsa:51379; Q2MLY7; Q8IUI8; Q9UNI3; Q9Y6M8" "NF1 copy number variation syndrome" "" "1" "0" "1.025" "0.967" "1.028" "1.030" "0.965" "0.997" "1.009" "0.974" "1.161" "2185.6" "2240.2" "2114.4" "2247.2" "2250.3" "2109.8" "2179.9" "2204.8" "2128.4" "2537.7" "" "" "" "" "" "" "" "" "" "" "1965.1" "1812.7" "1912.5" "2193.6" "1857.0" "2109.8" "1632.2" "1947.4" "1904.5" "905.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5305679341133587567" "False" "High" "IsMasterProtein" "Q86WR0" "Coiled-coil domain-containing protein 25 OS=Homo sapiens OX=9606 GN=CCDC25 PE=1 SV=2" "0.000" "False" "63.462" "64" "14" "23" "14" "208" "24.5" "6.80" "80.13" "14" "other biological processes" "plasma membrane;other membranes;other cell component" "nucleic acid binding activity" "Pf05670" "55246" "ENSG00000147419" "CCDC25" "hsa:55246; Q0P663; Q86WR0; Q96SI2; Q9NV98" "" "" "0" "0" "0.958" "0.947" "0.996" "0.965" "0.879" "1.007" "0.897" "0.933" "1.225" "2107.1" "2017.7" "1996.1" "2098.8" "2033.0" "1851.6" "2121.3" "1889.1" "1965.8" "2581.0" "" "" "" "" "" "" "" "" "" "" "1894.5" "1632.7" "1805.6" "2048.7" "1677.7" "1851.6" "1588.4" "1668.6" "1759.0" "921.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8166763961734876416" "False" "High" "IsMasterProtein" "P54727" "UV excision repair protein RAD23 homolog B OS=Homo sapiens OX=9606 GN=RAD23B PE=1 SV=1" "0.000" "False" "63.420" "23" "9" "35" "7" "409" "43.1" "4.84" "123.33" "9" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5887" "ENSG00000119318" "RAD23B" "B3KWK8; G5E9P0; hsa:5887; P54727; Q7Z5K8; Q8WUB0" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; HDAC6 interactions in the central nervous system" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "8" "2" "0.901" "0.910" "0.926" "0.943" "0.878" "0.944" "0.968" "0.885" "0.765" "4845.3" "4367.2" "4407.8" "4486.2" "4569.8" "4252.5" "4573.5" "4689.4" "4287.2" "3705.3" "" "" "" "" "" "" "" "" "" "" "4356.4" "3533.8" "3987.0" "4379.1" "3771.1" "4252.5" "3424.6" "4142.0" "3836.2" "1322.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110306690791428834" "False" "High" "IsMasterProtein" "P29218" "Inositol monophosphatase 1 OS=Homo sapiens OX=9606 GN=IMPA1 PE=1 SV=1" "0.000" "False" "63.229" "44" "12" "22" "12" "277" "30.2" "5.26" "85.05" "12" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf00459" "3612" "ENSG00000133731" "IMPA1" "B2R733; B4DLN3; B7Z6Q4; J3KQT7; P29218; Q9UK71" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "1.015" "0.979" "0.986" "1.064" "0.995" "1.035" "0.959" "1.020" "0.813" "1625.4" "1649.0" "1591.2" "1603.3" "1729.8" "1617.2" "1682.3" "1559.1" "1657.2" "1321.5" "" "" "" "" "" "" "" "" "" "" "1461.4" "1334.3" "1439.3" "1565.0" "1427.5" "1617.2" "1259.7" "1377.1" "1482.9" "471.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6888826320597161834" "False" "High" "IsMasterProtein" "Q16630" "Cleavage and polyadenylation specificity factor subunit 6 OS=Homo sapiens OX=9606 GN=CPSF6 PE=1 SV=2" "0.000" "False" "63.218" "25" "12" "27" "12" "551" "59.2" "7.15" "93.34" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00076" "11052" "ENSG00000111605" "CPSF6" "A8K7K9; hsa:11052; Q16630; Q53ES1; Q9BSJ7; Q9BW18" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "1.026" "1.095" "1.005" "1.076" "1.175" "1.048" "0.993" "1.083" "0.757" "1302.4" "1336.7" "1426.1" "1308.7" "1400.9" "1530.7" "1365.0" "1293.2" "1410.0" "985.9" "" "" "" "" "" "" "" "" "" "" "1171.0" "1081.6" "1289.9" "1277.5" "1156.0" "1530.7" "1022.1" "1142.3" "1261.7" "351.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8735053905858643513" "False" "High" "IsMasterProtein" "Q16401" "26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens OX=9606 GN=PSMD5 PE=1 SV=3" "0.000" "False" "63.173" "34" "15" "24" "15" "504" "56.2" "5.48" "81.64" "15" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf10508" "5711" "ENSG00000095261" "PSMD5" "B4DZM8; hsa:5711; Q15045; Q16401; Q4VXG8" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "UCH proteinases; Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; ER-Phagosome pathway; Regulation of expression of SLITs and ROBOs; Separation of Sister Chromatids; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.047" "0.984" "0.925" "1.023" "0.991" "1.099" "1.006" "0.965" "0.932" "1404.7" "1471.1" "1381.8" "1299.1" "1437.2" "1392.4" "1543.8" "1413.7" "1355.7" "1309.0" "" "" "" "" "" "" "" "" "" "" "1263.0" "1190.4" "1249.9" "1268.1" "1186.0" "1392.4" "1156.0" "1248.7" "1213.1" "467.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4018200245095699536" "False" "High" "IsMasterProtein" "P55327" "Tumor protein D52 OS=Homo sapiens OX=9606 GN=TPD52 PE=1 SV=2" "0.000" "False" "63.132" "42" "8" "31" "8" "224" "24.3" "4.83" "154.29" "8" "transport;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf04201" "7163" "ENSG00000076554" "TPD52" "B7Z414; C9J502; D0UFD1; D0UFD2; D0UFD3; D0UFD4; D0UFD5; E5RKB4; hsa:7163; P55327; Q13056; Q53EK8; Q6FGP3; Q6FGS3; Q86YZ2; Q9UCX8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.944" "0.917" "0.942" "0.909" "0.951" "0.962" "1.053" "0.858" "0.769" "3151.3" "2976.2" "2888.8" "2970.1" "2863.8" "2997.8" "3032.4" "3319.9" "2702.7" "2423.7" "" "" "" "" "" "" "" "" "" "" "2833.3" "2408.2" "2613.0" "2899.2" "2363.3" "2997.8" "2270.6" "2932.3" "2418.4" "865.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9037349892504840241" "False" "High" "IsMasterProtein" "O00764" "Pyridoxal kinase OS=Homo sapiens OX=9606 GN=PDXK PE=1 SV=1" "0.000" "False" "63.130" "44" "13" "25" "13" "312" "35.1" "6.13" "94.09" "13" "other metabolic processes" "non-structural extracellular;nucleus;other cell component" "kinase activity;other molecular function" "Pf08543" "8566" "ENSG00000160209" "PDXK" "O00764; Q7Z2Y0; Q9BS02" "" "Neutrophil degranulation; Vitamin B6 activation to pyridoxal phosphate" "2" "0" "1.072" "1.082" "1.095" "1.110" "1.081" "1.115" "1.044" "1.084" "0.981" "1778.2" "1906.9" "1924.0" "1947.6" "1973.3" "1921.6" "1982.9" "1856.0" "1927.5" "1743.9" "" "" "" "" "" "" "" "" "" "" "1598.8" "1543.0" "1740.3" "1901.1" "1628.4" "1921.6" "1484.8" "1639.3" "1724.7" "622.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271910638518906992" "False" "High" "IsMasterProtein" "Q92552" "Small ribosomal subunit protein mS27 OS=Homo sapiens OX=9606 GN=MRPS27 PE=1 SV=3" "0.000" "False" "63.093" "38" "15" "27" "15" "414" "47.6" "6.18" "84.95" "15" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10037" "23107" "ENSG00000113048" "MRPS27" "B4DRT2; hsa:23107; Q6P1S1; Q92552" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.022" "0.973" "1.009" "1.027" "0.966" "1.057" "1.014" "0.983" "1.083" "1796.2" "1835.4" "1747.8" "1811.8" "1843.8" "1735.0" "1897.6" "1821.7" "1766.2" "1945.2" "" "" "" "" "" "" "" "" "" "" "1614.9" "1485.2" "1580.9" "1768.5" "1521.5" "1735.0" "1420.9" "1609.1" "1580.4" "694.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4118942694403519746" "False" "High" "IsMasterProtein" "Q13492" "Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens OX=9606 GN=PICALM PE=1 SV=2" "0.000" "False" "63.084" "23" "12" "23" "10" "652" "70.7" "7.90" "84.12" "12" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf07651" "8301" "ENSG00000073921" "PICALM" "B4DTM3; E9PN05; F8VPG7; hsa:8301; O60700; Q13492; Q4LE54; Q6GMQ6; Q86XZ9" "" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; RND3 GTPase cycle" "4" "1" "0.994" "0.962" "0.933" "0.990" "0.948" "0.958" "0.976" "0.969" "0.768" "2433.8" "2418.2" "2340.2" "2271.4" "2409.4" "2306.3" "2331.3" "2374.4" "2358.1" "1868.8" "" "" "" "" "" "" "" "" "" "" "2188.2" "1956.7" "2116.8" "2217.2" "1988.3" "2306.3" "1745.6" "2097.2" "2110.0" "667.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3944775931209301438" "False" "High" "IsMasterProtein" "P60660" "Myosin light polypeptide 6 OS=Homo sapiens OX=9606 GN=MYL6 PE=1 SV=2" "0.000" "False" "63.079" "60" "9" "42" "7" "151" "16.9" "4.65" "150.11" "9" "other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "4637" "ENSG00000092841" "MYL6" "hsa:4637; P16475; P24572; P24573; P60660; Q12790; Q561V9; Q6IAZ0; Q6IPY5" "Ciliary landscape" "RHO GTPases activate CIT; EPHA-mediated growth cone collapse; Sema4D induced cell migration and growth-cone collapse; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "8" "3" "0.926" "1.268" "0.935" "1.022" "1.234" "1.039" "1.057" "1.230" "1.160" "3234.3" "2995.3" "4102.1" "3023.8" "3305.2" "3991.4" "3359.9" "3417.7" "3978.0" "3752.1" "" "" "" "" "" "" "" "" "" "" "2907.9" "2423.7" "3710.5" "2951.6" "2727.5" "3991.4" "2515.8" "3018.8" "3559.5" "1339.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "741210737454912212" "False" "High" "IsMasterProtein" "Q7Z7A4" "PX domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=PXK PE=1 SV=1" "0.000" "False" "62.964" "21" "12" "25" "11" "578" "64.9" "9.35" "99.35" "12" "stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00787, Pf02205" "54899" "ENSG00000168297" "PXK" "hsa:54899; Q3BCH4; Q3BCH5; Q3BCH6; Q3BDW1; Q45L83; Q59EX3; Q6PK17; Q6ZN39; Q7Z7A4; Q96CA3; Q96R07; Q9NXB8" "" "" "0" "1" "1.042" "0.972" "0.979" "1.047" "0.965" "1.057" "1.044" "0.972" "0.908" "1895.5" "1974.7" "1842.8" "1855.6" "1984.2" "1828.6" "2002.8" "1978.6" "1842.4" "1720.8" "" "" "" "" "" "" "" "" "" "" "1704.2" "1597.8" "1666.9" "1811.3" "1637.4" "1828.6" "1499.6" "1747.6" "1648.5" "614.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4793391525152750587" "False" "High" "IsMasterProtein" "P61020" "Ras-related protein Rab-5B OS=Homo sapiens OX=9606 GN=RAB5B PE=1 SV=1" "0.000" "False" "62.898" "59" "9" "24" "6" "215" "23.7" "8.13" "89.40" "9" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5869" "ENSG00000111540" "RAB5B" "A8K982; B4DKD7; hsa:5869; P35239; P35277; P61020; Q6PIK9; Q86TH0; Q8IXL2" "Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Respiratory syncytial virus (RSV) attachment and entry; Clathrin-mediated endocytosis; TBC/RABGAPs" "9" "0" "1.026" "0.974" "0.993" "1.067" "0.953" "0.941" "0.989" "1.025" "0.770" "919.5" "943.1" "896.0" "913.3" "981.3" "876.0" "864.8" "909.0" "942.3" "708.2" "" "" "" "" "" "" "" "" "" "" "826.7" "763.1" "810.4" "891.5" "809.8" "876.0" "647.5" "802.9" "843.2" "252.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2473277628257978921" "False" "High" "IsMasterProtein" "Q5SRE5" "Nucleoporin NUP188 OS=Homo sapiens OX=9606 GN=NUP188 PE=1 SV=1" "0.000" "False" "62.757" "11" "18" "21" "18" "1749" "195.9" "6.73" "74.95" "18" "transport" "cytosol;nucleus" "other molecular function" "Pf10487, Pf21093, Pf21094" "23511" "ENSG00000095319" "NUP188" "hsa:23511; Q14675; Q2TA87; Q5SRE5; Q7Z3K8; Q8IWF1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; SUMOylation of chromatin organization proteins; HCMV Early Events; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.078" "1.086" "0.914" "1.087" "1.026" "1.024" "0.979" "1.078" "1.344" "1497.1" "1614.2" "1626.4" "1369.1" "1627.3" "1535.8" "1532.3" "1465.8" "1614.4" "2011.9" "" "" "" "" "" "" "" "" "" "" "1346.1" "1306.1" "1471.2" "1336.4" "1342.8" "1535.8" "1147.4" "1294.7" "1444.5" "718.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3138004166962983246" "False" "High" "IsMasterProtein" "Q92688" "Acidic leucine-rich nuclear phosphoprotein 32 family member B OS=Homo sapiens OX=9606 GN=ANP32B PE=1 SV=1" "0.000" "False" "62.705" "32" "10" "75" "5" "251" "28.8" "4.06" "234.99" "10" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12799" "10541" "ENSG00000136938" "ANP32B" "B2R9C7; hsa:10541; O00655; P78458; P78459; Q92688" "" "" "0" "0" "0.950" "0.927" "0.934" "1.019" "0.912" "0.989" "0.970" "0.926" "0.821" "3243.3" "3080.3" "3007.7" "3028.2" "3306.0" "2958.9" "3207.6" "3147.3" "3003.6" "2663.3" "" "" "" "" "" "" "" "" "" "" "2916.1" "2492.4" "2720.6" "2956.0" "2728.1" "2958.9" "2401.7" "2779.9" "2687.6" "950.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1447147241946060131" "False" "High" "IsMasterProtein" "P61604" "10 kDa heat shock protein, mitochondrial OS=Homo sapiens OX=9606 GN=HSPE1 PE=1 SV=2" "0.000" "False" "62.699" "85" "13" "100" "13" "102" "10.9" "8.92" "324.80" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00166" "3336" "ENSG00000115541" "HSPE1" "hsa:3336; O95421; P61604; Q04984; Q53X54; Q9UDH0" "" "RHOG GTPase cycle" "1" "0" "0.947" "0.926" "0.934" "0.935" "0.961" "0.950" "1.013" "0.916" "0.714" "12208.7" "11560.8" "11305.3" "11407.5" "11421.1" "11727.9" "11594.9" "12363.4" "11182.6" "8719.2" "" "" "" "" "" "" "" "" "" "" "10976.8" "9354.6" "10226.1" "11135.3" "9424.9" "11727.9" "8682.0" "10920.1" "10006.1" "3112.5" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7989790464056543145" "False" "High" "IsMasterProtein" "Cont_P35527" "Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3" "0.000" "True" "62.645" "23" "15" "25" "14" "623" "62.0" "5.24" "96.68" "15" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00038" "3857; 454664" "ENSG00000171403; ENSPTRG00000009169" "KRT9" "A0A2J8KG96; A0A6D2VYW7; H2QCZ6; hsa:3857; O00109; P35527; ptr:454664; Q0IJ47; Q14665" "" "Formation of the cornified envelope" "2" "0" "0.511" "0.453" "0.871" "0.580" "1.767" "2.319" "1.767" "1.016" "1.743" "1781.9" "911.2" "806.7" "1551.3" "1032.7" "3148.8" "4131.5" "3149.2" "1810.3" "3106.3" "" "" "" "" "" "" "" "" "" "" "1602.1" "737.4" "729.6" "1514.3" "852.2" "3148.8" "3093.5" "2781.6" "1619.8" "1108.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6692075332981007833" "False" "High" "IsMasterProtein" "Q13451" "Peptidyl-prolyl cis-trans isomerase FKBP5 OS=Homo sapiens OX=9606 GN=FKBP5 PE=1 SV=2" "0.000" "False" "62.644" "35" "15" "24" "15" "457" "51.2" "5.90" "89.83" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00254, Pf00515" "2289" "ENSG00000096060" "FKBP5" "F5H7R1; hsa:2289; Q13451; Q59EB8; Q5TGM6" "Androgen receptor network in prostate cancer; Farnesoid X receptor pathway; Nuclear receptors meta-pathway; MECP2 and associated Rett syndrome" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; ESR-mediated signaling; MECP2 regulates neuronal receptors and channels" "7" "0" "0.958" "0.964" "0.941" "0.974" "1.028" "0.992" "0.871" "0.965" "5.686" "1532.1" "1468.1" "1477.6" "1441.5" "1492.3" "1575.7" "1519.4" "1334.8" "1479.2" "8712.5" "" "" "" "" "" "" "" "" "" "" "1377.5" "1187.9" "1336.5" "1407.2" "1231.5" "1575.7" "1137.7" "1179.0" "1323.6" "3110.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5390020710088679993" "False" "High" "IsMasterProtein" "O75368" "Adapter SH3BGRL OS=Homo sapiens OX=9606 GN=SH3BGRL PE=1 SV=1" "0.000" "False" "62.549" "85" "9" "38" "9" "114" "12.8" "5.25" "146.03" "9" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04908" "6451" "ENSG00000131171" "SH3BGRL" "hsa:6451; O75368; Q3SYL1; Q5JT50; Q6FIE8; Q9H0N8" "" "" "0" "0" "0.967" "0.899" "0.966" "0.985" "0.955" "0.942" "1.019" "0.929" "0.735" "4025.0" "3893.4" "3617.6" "3888.5" "3963.3" "3842.0" "3790.9" "4102.3" "3740.5" "2958.1" "" "" "" "" "" "" "" "" "" "" "3618.8" "3150.4" "3272.2" "3795.7" "3270.6" "3842.0" "2838.5" "3623.4" "3347.0" "1056.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5720484629679422275" "False" "High" "IsMasterProtein" "Q8WUA2" "Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens OX=9606 GN=PPIL4 PE=1 SV=1" "0.000" "False" "62.547" "38" "16" "23" "16" "492" "57.2" "5.92" "86.79" "16" "" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00160" "85313" "ENSG00000131013" "PPIL4" "B2RD34; hsa:85313; Q7Z3Q5; Q8WUA2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.961" "1.091" "0.973" "1.041" "1.050" "0.980" "0.934" "1.032" "1.127" "1053.4" "1012.2" "1149.2" "1024.8" "1096.4" "1106.0" "1032.6" "984.3" "1087.4" "1187.0" "" "" "" "" "" "" "" "" "" "" "947.1" "819.0" "1039.5" "1000.3" "904.8" "1106.0" "773.2" "869.4" "973.0" "423.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845152794455651809" "False" "High" "IsMasterProtein" "O75179" "Ankyrin repeat domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ANKRD17 PE=1 SV=3" "0.000" "False" "62.529" "7" "17" "20" "8" "2603" "274.1" "6.52" "72.88" "17" "stress response;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf00013, Pf12796, Pf13637" "26057" "ENSG00000132466" "ANKRD17" "E7EUV3; G5E964; hsa:26057; O75179; Q6PJ85; Q6PK85; Q6PKA2; Q86XI3; Q8NDR5; Q96I86; Q9H288; Q9H6J9" "" "" "0" "7" "1.017" "1.023" "0.965" "1.047" "0.990" "1.004" "0.956" "1.001" "2.012" "1099.2" "1118.3" "1124.3" "1061.0" "1151.2" "1088.6" "1103.1" "1050.8" "1099.9" "2211.3" "" "" "" "" "" "" "" "" "" "" "988.3" "904.9" "1016.9" "1035.7" "950.0" "1088.6" "826.0" "928.2" "984.1" "789.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3557682221437211922" "False" "High" "IsMasterProtein" "Q9Y6Q9" "Nuclear receptor coactivator 3 OS=Homo sapiens OX=9606 GN=NCOA3 PE=1 SV=1" "0.000" "False" "62.514" "14" "15" "22" "15" "1424" "155.2" "7.47" "76.62" "15" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00989, Pf07469, Pf08815, Pf08832, Pf14598, Pf16279, Pf16665" "8202" "ENSG00000124151" "NCOA3" "A4LAZ5; hsa:8202; Q0VF45; Q5JYD9; Q5JYE0; Q9BR49; Q9UPC9; Q9UPG4; Q9UPG7; Q9Y6Q9" "Androgen receptor signaling pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Breast cancer pathway; EGF/EGFR signaling pathway; Rubinstein-Taybi syndrome 1" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; MAPK6/MAPK4 signaling; Estrogen-dependent gene expression" "11" "0" "0.984" "0.872" "0.932" "0.976" "0.857" "0.994" "0.976" "0.901" "1.058" "1001.7" "985.8" "873.3" "933.1" "977.7" "858.4" "995.3" "977.2" "902.8" "1059.9" "" "" "" "" "" "" "" "" "" "" "900.6" "797.7" "790.0" "910.9" "806.8" "858.4" "745.3" "863.1" "807.8" "378.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6359108141380896600" "False" "High" "IsMasterProtein" "Q86W50" "RNA N6-adenosine-methyltransferase METTL16 OS=Homo sapiens OX=9606 GN=METTL16 PE=1 SV=2" "0.000" "False" "62.467" "29" "13" "19" "13" "562" "63.6" "7.85" "79.10" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05971" "79066" "ENSG00000127804" "METTL16" "D3DTI8; hsa:79066; Q86TE5; Q86W50; Q96T16; Q9BVG7" "" "" "0" "0" "1.071" "0.972" "1.029" "1.064" "0.949" "1.034" "1.024" "1.033" "0.995" "1196.3" "1280.9" "1162.5" "1230.7" "1273.0" "1134.8" "1236.5" "1225.5" "1236.3" "1190.5" "" "" "" "" "" "" "" "" "" "" "1075.6" "1036.5" "1051.5" "1201.3" "1050.5" "1134.8" "925.9" "1082.5" "1106.2" "425.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538184499835993456" "False" "High" "IsMasterProtein" "P43897" "Elongation factor Ts, mitochondrial OS=Homo sapiens OX=9606 GN=TSFM PE=1 SV=2" "0.000" "False" "62.447" "40" "12" "21" "12" "325" "35.4" "8.38" "91.99" "12" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity" "Pf00889" "10102" "ENSG00000123297" "TSFM" "B4E391; F5H2T7; hsa:10102; P43897; Q561V7; Q8TBC2; Q9UQK0" "" "Mitochondrial translation elongation" "1" "0" "1.054" "1.085" "1.006" "1.073" "1.069" "1.005" "1.146" "1.173" "1.470" "2591.4" "2731.7" "2812.7" "2607.5" "2779.6" "2770.6" "2603.2" "2969.4" "3039.9" "3808.2" "" "" "" "" "" "" "" "" "" "" "2329.9" "2210.4" "2544.2" "2545.3" "2293.8" "2770.6" "1949.2" "2622.8" "2720.0" "1359.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1871609499973025843" "False" "High" "IsMasterProtein" "Q07021" "Complement component 1 Q subcomponent-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=C1QBP PE=1 SV=1" "0.000" "False" "62.402" "43" "8" "44" "8" "282" "31.3" "4.84" "212.67" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;translation activity;nucleic acid binding activity;other molecular function" "Pf02330" "708" "ENSG00000108561" "C1QBP" "hsa:708; Q07021; Q2HXR8; Q9NNY8" "Complement system; Mesodermal commitment pathway; Ebola virus infection in host" "RHOC GTPase cycle; RHOA GTPase cycle; Intrinsic Pathway of Fibrin Clot Formation; Apoptotic factor-mediated response; Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function" "8" "0" "1.062" "0.961" "1.077" "0.918" "1.160" "1.036" "1.044" "0.939" "0.882" "4542.0" "4824.5" "4365.0" "4893.4" "4169.5" "5269.2" "4706.3" "4743.8" "4266.0" "4008.2" "" "" "" "" "" "" "" "" "" "" "4083.7" "3903.8" "3948.3" "4776.6" "3440.8" "5269.2" "3524.0" "4190.0" "3817.1" "1430.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8648350258145669710" "False" "High" "IsMasterProtein" "Q15717" "ELAV-like protein 1 OS=Homo sapiens OX=9606 GN=ELAVL1 PE=1 SV=2" "0.000" "False" "62.335" "37" "10" "31" "10" "326" "36.1" "9.17" "120.45" "10" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1994" "ENSG00000066044" "ELAVL1" "B4DVB8; hsa:1994; Q15717; Q53XN6; Q9BTT1" "AMP-activated protein kinase signaling; Endoderm differentiation; Pre-implantation embryo; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Gastrin signaling pathway; IL-18 signaling pathway; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; 1p36 copy number variation syndrome" "HuR (ELAVL1) binds and stabilizes mRNA" "10" "0" "0.973" "0.991" "1.066" "0.984" "0.924" "1.041" "0.987" "0.926" "1.511" "3124.6" "3041.5" "3095.0" "3330.4" "3074.7" "2887.7" "3253.3" "3082.7" "2894.1" "4721.7" "" "" "" "" "" "" "" "" "" "" "2809.3" "2461.1" "2799.5" "3250.9" "2537.3" "2887.7" "2436.0" "2722.8" "2589.6" "1685.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1084161266970488512" "False" "High" "IsMasterProtein" "Q04206" "Transcription factor p65 OS=Homo sapiens OX=9606 GN=RELA PE=1 SV=2" "0.000" "False" "62.334" "33" "15" "22" "15" "551" "60.2" "5.68" "80.25" "15" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "5970" "ENSG00000173039" "RELA" "hsa:5970; Q04206; Q6GTV1; Q6SLK1" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Selenium metabolism and selenoproteins; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; ApoE and miR-146 in inflammation and atherosclerosis; Chemokine signaling pathway; IL-4 signaling pathway; NO/cGMP/PKG mediated neuroprotection; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; CAMKK2 pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; Opioid receptor pathways; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; Osteoarthritic chondrocyte hypertrophy; 15q11q13 copy number variation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; Transcriptional regulation of white adipocyte differentiation; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "101" "0" "1.066" "1.018" "0.975" "1.087" "1.027" "1.057" "1.027" "1.028" "1.234" "1021.8" "1089.4" "1039.9" "996.6" "1110.4" "1049.3" "1080.2" "1049.0" "1050.8" "1260.4" "" "" "" "" "" "" "" "" "" "" "918.7" "881.5" "940.6" "972.9" "916.3" "1049.3" "808.8" "926.6" "940.2" "449.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6706450895826488783" "False" "High" "IsMasterProtein" "Q9H9Q2" "COP9 signalosome complex subunit 7b OS=Homo sapiens OX=9606 GN=COPS7B PE=1 SV=1" "0.000" "False" "62.332" "35" "7" "22" "7" "264" "29.6" "6.15" "106.16" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "64708" "ENSG00000144524" "COPS7B" "hsa:64708; Q53S22; Q5BJG3; Q9H7V6; Q9H9Q2" "Ciliary landscape" "Neddylation; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; DNA Damage Recognition in GG-NER" "5" "0" "0.939" "0.988" "1.016" "1.050" "0.964" "1.034" "1.006" "0.940" "0.833" "1377.6" "1293.3" "1360.9" "1399.8" "1446.7" "1328.0" "1424.8" "1386.0" "1294.7" "1147.9" "" "" "" "" "" "" "" "" "" "" "1238.6" "1046.5" "1231.0" "1366.4" "1193.9" "1328.0" "1066.9" "1224.2" "1158.5" "409.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3546401136209877532" "False" "High" "IsMasterProtein" "O75821" "Eukaryotic translation initiation factor 3 subunit G OS=Homo sapiens OX=9606 GN=EIF3G PE=1 SV=2" "0.000" "False" "62.276" "38" "10" "29" "10" "320" "35.6" "6.13" "111.83" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12353" "8666" "ENSG00000130811" "EIF3G" "hsa:8666; O14801; O75821; Q969U5" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "0.964" "0.982" "1.000" "0.977" "1.033" "0.963" "0.982" "0.990" "1.491" "3278.0" "3161.6" "3217.9" "3278.3" "3202.9" "3386.7" "3156.6" "3219.1" "3245.1" "4887.9" "" "" "" "" "" "" "" "" "" "" "2947.3" "2558.2" "2910.7" "3200.1" "2643.1" "3386.7" "2363.6" "2843.3" "2903.7" "1744.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257366520332167042" "False" "High" "IsMasterProtein" "Q13422" "DNA-binding protein Ikaros OS=Homo sapiens OX=9606 GN=IKZF1 PE=1 SV=1" "0.000" "False" "62.254" "29" "14" "28" "10" "519" "57.5" "6.58" "95.64" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "10320" "ENSG00000185811" "IKZF1" "A4D260; B4E0Z1; D3DVM5; hsa:10320; O00598; Q13422; Q53XL2; Q69BM4; Q8WVA3" "Hematopoietic stem cell differentiation; Development of pulmonary dendritic cells and macrophage subsets" "" "2" "3" "0.981" "0.885" "1.013" "1.008" "0.931" "1.114" "1.000" "0.886" "1.240" "2052.4" "2013.1" "1816.0" "2078.1" "2069.1" "1911.5" "2287.3" "2051.7" "1817.7" "2545.8" "" "" "" "" "" "" "" "" "" "" "1845.3" "1628.9" "1642.6" "2028.5" "1707.5" "1911.5" "1712.7" "1812.2" "1626.5" "908.8" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2413702222549115072" "False" "High" "IsMasterProtein" "P13693" "Translationally-controlled tumor protein OS=Homo sapiens OX=9606 GN=TPT1 PE=1 SV=1" "0.000" "False" "62.218" "57" "9" "47" "9" "172" "19.6" "4.93" "155.55" "9" "transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00838" "7178" "ENSG00000133112" "TPT1" "B2R7E5; hsa:7178; P13693; Q6YLS2; Q7Z4J4; Q8TBK7; Q96EE2; Q9UC70" "" "" "0" "0" "0.898" "0.910" "0.991" "0.910" "0.908" "0.962" "0.949" "0.919" "0.887" "5274.7" "4738.6" "4800.5" "5229.6" "4800.1" "4788.0" "5075.4" "5003.7" "4845.6" "4679.5" "" "" "" "" "" "" "" "" "" "" "4742.5" "3834.3" "4342.2" "5104.8" "3961.1" "4788.0" "3800.4" "4419.6" "4335.8" "1670.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3053469202622973433" "False" "High" "IsMasterProtein" "Q7L591" "Docking protein 3 OS=Homo sapiens OX=9606 GN=DOK3 PE=1 SV=2" "0.000" "False" "62.197" "37" "14" "22" "14" "496" "53.3" "7.77" "81.63" "14" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf02174" "79930" "ENSG00000146094" "DOK3" "E9PAT0; H7BXS0; hsa:79930; Q7L591; Q8N864; Q9BQB3; Q9H666" "5q35 copy number variation" "Neutrophil degranulation" "2" "0" "1.063" "1.007" "0.999" "1.061" "1.119" "1.082" "1.069" "0.960" "1.119" "1330.3" "1413.6" "1339.7" "1329.0" "1411.8" "1488.5" "1439.2" "1422.3" "1276.5" "1489.0" "" "" "" "" "" "" "" "" "" "" "1196.1" "1143.8" "1211.8" "1297.3" "1165.0" "1488.5" "1077.6" "1256.3" "1142.2" "531.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4989435524198560061" "False" "High" "IsMasterProtein" "P48506" "Glutamate--cysteine ligase catalytic subunit OS=Homo sapiens OX=9606 GN=GCLC PE=1 SV=2" "0.000" "False" "62.162" "25" "14" "23" "13" "637" "72.7" "6.09" "87.44" "14" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03074" "2729" "ENSG00000001084" "GCLC" "hsa:2729; P48506; Q14399" "Glutathione metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; One-carbon metabolism and related pathways; Oxidative stress response; Ferroptosis; NRF2-ARE regulation; Vitamin D-sensitive calcium signaling in depression; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "17" "0" "1.013" "1.011" "0.935" "1.034" "0.925" "0.985" "1.003" "0.999" "0.844" "1584.1" "1604.6" "1601.0" "1481.3" "1638.0" "1464.5" "1560.5" "1589.6" "1582.3" "1336.4" "" "" "" "" "" "" "" "" "" "" "1424.2" "1298.4" "1448.1" "1446.0" "1351.7" "1464.5" "1168.4" "1404.0" "1415.8" "477.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4388316332710741736" "False" "High" "IsMasterProtein" "Q96FS4" "Signal-induced proliferation-associated protein 1 OS=Homo sapiens OX=9606 GN=SIPA1 PE=1 SV=1" "0.000" "False" "62.120" "21" "15" "19" "15" "1042" "112.1" "6.60" "75.10" "15" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf21022" "6494" "ENSG00000213445" "SIPA1" "hsa:6494; O14518; O60484; O60618; Q2YD83; Q96FS4" "MAPK cascade" "Rap1 signalling" "2" "0" "1.059" "1.038" "0.978" "1.035" "1.062" "1.042" "1.061" "1.037" "1.028" "1202.6" "1273.4" "1248.6" "1176.0" "1244.8" "1277.1" "1253.5" "1276.5" "1246.6" "1236.0" "" "" "" "" "" "" "" "" "" "" "1081.3" "1030.4" "1129.4" "1147.9" "1027.3" "1277.1" "938.6" "1127.5" "1115.4" "441.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8311044657227682609" "False" "High" "IsMasterProtein" "Q9BZE9" "Tether containing UBX domain for GLUT4 OS=Homo sapiens OX=9606 GN=ASPSCR1 PE=1 SV=1" "0.000" "False" "62.096" "41" "16" "20" "16" "553" "60.1" "6.64" "86.20" "16" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf00789, Pf11470" "79058" "ENSG00000169696" "ASPSCR1" "A8K3K9; hsa:79058; Q7Z6N7; Q8WV59; Q96LS5; Q96M40; Q9BZE9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.061" "1.030" "1.026" "1.103" "1.018" "1.038" "1.031" "1.024" "0.999" "1606.7" "1704.3" "1654.2" "1648.9" "1773.0" "1636.3" "1667.4" "1657.2" "1645.2" "1604.8" "" "" "" "" "" "" "" "" "" "" "1444.6" "1379.1" "1496.3" "1609.5" "1463.1" "1636.3" "1248.5" "1463.7" "1472.1" "572.9" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5048841209035306562" "False" "High" "IsMasterProtein" "Q9H845" "Complex I assembly factor ACAD9, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD9 PE=1 SV=1" "0.000" "False" "62.060" "27" "16" "21" "16" "621" "68.7" "7.96" "69.21" "16" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00441, Pf02770, Pf02771, Pf21343" "28976" "ENSG00000177646" "ACAD9" "D3DNB8; hsa:28976; Q8WXX3; Q9H845" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "3" "0" "0.987" "0.978" "0.915" "1.005" "0.929" "1.007" "0.945" "0.957" "0.842" "1712.2" "1690.7" "1674.6" "1567.4" "1720.2" "1591.0" "1724.5" "1617.6" "1639.0" "1440.9" "" "" "" "" "" "" "" "" "" "" "1539.5" "1368.0" "1514.7" "1530.0" "1419.5" "1591.0" "1291.3" "1428.8" "1466.5" "514.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3321226471008760" "False" "High" "IsMasterProtein" "Q9Y2Q3" "Glutathione S-transferase kappa 1 OS=Homo sapiens OX=9606 GN=GSTK1 PE=1 SV=3" "0.000" "False" "61.979" "59" "10" "28" "10" "226" "25.5" "8.41" "90.29" "10" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf01323" "373156" "ENSG00000197448" "GSTK1" "B4DIH1; B4DSY2; hsa:373156; Q6P4H0; Q7Z520; Q9P1S4; Q9Y2Q3" "Metapathway biotransformation Phase I and II" "Peroxisomal protein import; Glutathione conjugation" "3" "0" "0.974" "1.017" "0.965" "0.973" "0.952" "0.965" "1.025" "1.036" "0.798" "2798.3" "2726.0" "2846.7" "2699.0" "2723.7" "2663.4" "2699.4" "2868.4" "2900.3" "2232.1" "" "" "" "" "" "" "" "" "" "" "2516.0" "2205.8" "2574.9" "2634.6" "2247.6" "2663.4" "2021.2" "2533.5" "2595.2" "796.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036533815918111608" "False" "High" "IsMasterProtein" "Q9NP72" "Ras-related protein Rab-18 OS=Homo sapiens OX=9606 GN=RAB18 PE=1 SV=1" "0.000" "False" "61.838" "57" "9" "18" "9" "206" "23.0" "5.24" "73.40" "9" "cell organization and biogenesis;transport;developmental processes;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "22931" "ENSG00000099246" "RAB18" "B3KMC7; B7Z333; D3DRW1; hsa:22931; Q53FX8; Q56UN9; Q6FIH1; Q9NP72" "" "Neutrophil degranulation; RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; COPI-independent Golgi-to-ER retrograde traffic" "4" "0" "1.033" "1.000" "0.944" "0.999" "0.945" "0.970" "0.955" "0.984" "0.713" "1562.9" "1614.8" "1562.5" "1475.4" "1561.4" "1477.1" "1515.5" "1492.2" "1538.0" "1115.1" "" "" "" "" "" "" "" "" "" "" "1405.2" "1306.6" "1413.3" "1440.2" "1288.5" "1477.1" "1134.8" "1318.0" "1376.2" "398.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3382226448836069029" "False" "High" "IsMasterProtein" "Q69YH5" "Cell division cycle-associated protein 2 OS=Homo sapiens OX=9606 GN=CDCA2 PE=1 SV=2" "0.000" "False" "61.794" "18" "13" "20" "13" "1023" "112.6" "8.40" "73.18" "13" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15276" "157313" "ENSG00000184661" "CDCA2" "hsa:157313; Q3SX74; Q4G0W0; Q5RKN0; Q69YH5; Q69YI4; Q6P464; Q8N7C1" "" "" "0" "0" "0.979" "1.046" "0.962" "1.044" "1.006" "1.080" "0.999" "1.016" "1.085" "1644.3" "1609.8" "1720.1" "1582.5" "1716.2" "1653.5" "1775.3" "1642.2" "1670.5" "1783.3" "" "" "" "" "" "" "" "" "" "" "1478.4" "1302.6" "1555.9" "1544.8" "1416.3" "1653.5" "1329.3" "1450.5" "1494.8" "636.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3208052669097016746" "False" "High" "IsMasterProtein" "P51608" "Methyl-CpG-binding protein 2 OS=Homo sapiens OX=9606 GN=MECP2 PE=1 SV=1" "0.000" "False" "61.562" "31" "12" "20" "12" "486" "52.4" "9.95" "70.90" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429" "4204" "ENSG00000169057" "MECP2" "hsa:4204; O15233; P51608; Q6QHH9; Q7Z384" "Ectoderm differentiation; MECP2 and associated Rett syndrome; Lung fibrosis; Rett syndrome; Transcription co-factors SKI and SKIL protein partners; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Neurogenesis regulation in the olfactory epithelium; ADHD and autism (ASD) linked metabolic pathways and SNP; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "10" "0" "0.934" "0.943" "0.959" "1.004" "0.989" "0.935" "0.915" "0.941" "0.781" "1480.7" "1383.6" "1396.5" "1419.9" "1485.9" "1464.7" "1383.9" "1355.3" "1393.7" "1156.7" "" "" "" "" "" "" "" "" "" "" "1331.3" "1119.5" "1263.2" "1386.0" "1226.2" "1464.7" "1036.2" "1197.1" "1247.0" "412.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494116660910275017" "False" "High" "IsMasterProtein" "Q9H814" "Phosphorylated adapter RNA export protein OS=Homo sapiens OX=9606 GN=PHAX PE=1 SV=1" "0.000" "False" "61.305" "42" "12" "22" "12" "394" "44.4" "5.40" "86.87" "12" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10258" "51808" "ENSG00000164902" "PHAX" "hsa:51808; Q9H814; Q9H8W1" "" "RNA polymerase II transcribes snRNA genes; snRNP Assembly" "2" "0" "0.956" "1.035" "0.963" "1.023" "0.988" "0.995" "0.995" "1.022" "0.887" "1980.8" "1893.1" "2050.3" "1908.0" "2025.9" "1957.1" "1970.7" "1970.1" "2025.2" "1756.2" "" "" "" "" "" "" "" "" "" "" "1780.9" "1531.8" "1854.5" "1862.4" "1671.8" "1957.1" "1475.6" "1740.1" "1812.1" "626.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8642503759764886067" "False" "High" "IsMasterProtein" "P49454" "Centromere protein F OS=Homo sapiens OX=9606 GN=CENPF PE=1 SV=3" "0.000" "False" "61.266" "7" "21" "21" "21" "3114" "357.3" "5.10" "66.22" "21" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10473, Pf10481, Pf10490" "1063" "ENSG00000117724" "CENPF" "hsa:1063; P49454; Q13171; Q13246; Q5VVM7" "Gastric cancer network 1; Ciliopathies" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Polo-like kinase mediated events" "9" "0" "1.087" "1.136" "0.965" "1.056" "1.121" "1.099" "1.044" "1.134" "1.398" "1076.3" "1170.3" "1222.5" "1038.4" "1136.1" "1206.4" "1182.9" "1123.3" "1220.4" "1504.2" "" "" "" "" "" "" "" "" "" "" "967.7" "946.9" "1105.8" "1013.6" "937.5" "1206.4" "885.8" "992.2" "1092.0" "537.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2943690132932996841" "False" "High" "IsMasterProtein" "P10412" "Histone H1.4 OS=Homo sapiens OX=9606 GN=H1-4 PE=1 SV=2" "0.000" "False" "61.166" "37" "12" "31" "3" "219" "21.9" "11.03" "119.16" "12" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3008" "ENSG00000168298" "H1-4" "hsa:3008; P10412; Q4VB25" "Pathways affected in adenoid cystic carcinoma" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "3" "0" "1.045" "0.768" "0.958" "0.583" "0.931" "0.778" "0.869" "0.541" "0.598" "716.7" "748.8" "550.1" "686.5" "418.1" "667.3" "557.6" "622.6" "388.0" "428.2" "" "" "" "" "" "" "" "" "" "" "644.3" "605.9" "497.6" "670.1" "345.0" "667.3" "417.5" "549.9" "347.1" "152.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3464884523288308990" "False" "High" "IsMasterProtein" "Q12972" "Nuclear inhibitor of protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PPP1R8 PE=1 SV=2" "0.000" "False" "61.141" "42" "10" "14" "10" "351" "38.5" "7.37" "75.02" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00498" "5511" "ENSG00000117751" "PPP1R8" "hsa:5511; Q12972; Q5TEJ2; Q5TEJ4; Q5TIF2; Q6PKF6; Q9UBH1; Q9UBZ0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.988" "0.992" "0.967" "1.021" "1.047" "0.935" "1.016" "1.011" "0.868" "1276.8" "1261.0" "1267.0" "1234.5" "1304.3" "1336.3" "1193.9" "1297.6" "1290.7" "1108.4" "" "" "" "" "" "" "" "" "" "" "1148.0" "1020.4" "1146.0" "1205.0" "1076.3" "1336.3" "894.0" "1146.2" "1154.9" "395.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740518017781001578" "False" "High" "IsMasterProtein" "Q8WW12" "PEST proteolytic signal-containing nuclear protein OS=Homo sapiens OX=9606 GN=PCNP PE=1 SV=2" "0.000" "False" "61.128" "62" "9" "18" "9" "178" "18.9" "7.49" "78.21" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "nucleus" "" "Pf15473" "57092" "ENSG00000081154" "PCNP" "B2RBE7; D3DN52; hsa:57092; Q53GF3; Q6AI44; Q8WW12; Q96CU3; Q9NS81" "" "" "0" "0" "0.929" "0.953" "0.993" "0.974" "1.046" "0.930" "1.110" "0.978" "0.776" "1962.4" "1824.0" "1870.3" "1948.4" "1912.3" "2053.5" "1824.5" "2177.6" "1920.1" "1523.6" "" "" "" "" "" "" "" "" "" "" "1764.4" "1475.9" "1691.8" "1901.9" "1578.1" "2053.5" "1366.2" "1923.4" "1718.1" "543.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7869799461247912985" "False" "High" "IsMasterProtein" "Q96GW9" "Methionine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=MARS2 PE=1 SV=2" "0.000" "False" "61.075" "31" "14" "17" "14" "593" "66.5" "8.09" "71.42" "14" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf09334, Pf19303" "92935" "ENSG00000247626" "MARS2" "A0AVC3; hsa:92935; Q76E79; Q8IW62; Q8N7N4; Q96GW9" "Amino acid metabolism" "Mitochondrial tRNA aminoacylation" "2" "0" "1.049" "0.988" "0.992" "1.073" "0.966" "1.052" "1.051" "1.035" "0.846" "1286.8" "1349.6" "1271.4" "1275.9" "1380.9" "1242.5" "1353.4" "1352.2" "1331.9" "1088.0" "" "" "" "" "" "" "" "" "" "" "1156.9" "1092.1" "1150.0" "1245.4" "1139.6" "1242.5" "1013.4" "1194.3" "1191.8" "388.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5453029631849906368" "False" "High" "IsMasterProtein" "Q9NRN7" "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2" "0.000" "False" "61.057" "40" "13" "33" "13" "309" "35.8" "6.80" "103.96" "13" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01648" "60496" "ENSG00000149313" "AASDHPPT" "B2R6D1; B4DDW7; hsa:60496; Q9C068; Q9NRN7; Q9P0Q3; Q9UG80; Q9Y389" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "1.007" "0.972" "0.982" "1.003" "0.998" "1.037" "1.024" "0.989" "0.827" "3018.1" "3040.2" "2934.3" "2963.1" "3027.3" "3012.0" "3130.7" "3090.2" "2985.9" "2495.1" "" "" "" "" "" "" "" "" "" "" "2713.6" "2460.1" "2654.2" "2892.4" "2498.2" "3012.0" "2344.2" "2729.5" "2671.8" "890.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2834511568131292996" "False" "High" "IsMasterProtein" "O00329" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2" "0.000" "False" "61.015" "19" "18" "20" "17" "1044" "119.4" "7.18" "77.46" "18" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5293" "ENSG00000171608" "PIK3CD" "A6NCG0; G1FFP1; hsa:5293; O00329; O15445; Q5SR49" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; IL-3 signaling pathway; Focal adhesion; Overview of nanoparticle effects; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL" "56" "1" "1.097" "1.034" "1.010" "1.036" "1.030" "1.098" "1.015" "1.059" "0.920" "1691.2" "1855.8" "1747.9" "1708.7" "1752.4" "1741.5" "1857.2" "1716.4" "1791.2" "1556.4" "" "" "" "" "" "" "" "" "" "" "1520.6" "1501.6" "1581.0" "1667.9" "1446.1" "1741.5" "1390.6" "1516.0" "1602.8" "555.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5557556089384344895" "False" "High" "IsMasterProtein" "Q9UN86" "Ras GTPase-activating protein-binding protein 2 OS=Homo sapiens OX=9606 GN=G3BP2 PE=1 SV=2" "0.000" "False" "60.991" "34" "14" "27" "14" "482" "54.1" "5.55" "88.37" "14" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf02136" "9908" "ENSG00000138757" "G3BP2" "A8K6X1; hsa:9908; O60606; O75149; Q9UN86; Q9UPA1" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "1.032" "1.094" "1.106" "0.989" "1.198" "0.982" "1.037" "1.074" "0.908" "1634.5" "1687.5" "1788.2" "1808.0" "1617.4" "1957.9" "1605.5" "1695.2" "1755.9" "1484.4" "" "" "" "" "" "" "" "" "" "" "1469.6" "1365.5" "1617.4" "1764.8" "1334.7" "1957.9" "1202.2" "1497.3" "1571.2" "529.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8633785530779633839" "False" "High" "IsMasterProtein" "P49354" "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Homo sapiens OX=9606 GN=FNTA PE=1 SV=1" "0.000" "False" "60.961" "35" "12" "25" "12" "379" "44.4" "5.08" "90.25" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01239" "2339" "ENSG00000168522" "FNTA" "A6NJW0; hsa:2339; P49354; Q53XJ9; Q9UDC1" "Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Familial partial lipodystrophy; Progeria-associated lipodystrophy; Acquired partial lipodystrophy / Barraquer-Simons syndrome" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing; Apoptotic cleavage of cellular proteins" "9" "0" "0.954" "1.024" "0.964" "0.976" "0.974" "0.994" "0.974" "0.986" "0.884" "1803.0" "1719.4" "1846.3" "1738.6" "1760.3" "1755.8" "1792.8" "1755.4" "1778.6" "1593.3" "" "" "" "" "" "" "" "" "" "" "1621.0" "1391.3" "1670.0" "1697.1" "1452.6" "1755.8" "1342.4" "1550.5" "1591.4" "568.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3175822401937946454" "False" "High" "IsMasterProtein" "Q15942" "Zyxin OS=Homo sapiens OX=9606 GN=ZYX PE=1 SV=1" "0.000" "False" "60.930" "26" "11" "25" "11" "572" "61.2" "6.67" "97.03" "11" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "7791" "ENSG00000159840; ENSG00000285443" "ZYX" "A4D2G6; B4DQX7; hsa:7791; Q15942; Q6I9S4" "Integrin-mediated cell adhesion; Focal adhesion" "" "2" "0" "0.907" "0.933" "0.950" "0.979" "0.994" "0.936" "0.999" "0.944" "0.814" "1781.1" "1616.2" "1661.2" "1692.9" "1743.7" "1770.8" "1667.7" "1779.7" "1681.1" "1450.0" "" "" "" "" "" "" "" "" "" "" "1601.3" "1307.8" "1502.6" "1652.5" "1438.9" "1770.8" "1248.7" "1571.9" "1504.2" "517.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "52020500018808800" "False" "High" "IsMasterProtein" "Q9H773" "dCTP pyrophosphatase 1 OS=Homo sapiens OX=9606 GN=DCTPP1 PE=1 SV=1" "0.000" "False" "60.924" "62" "9" "33" "9" "170" "18.7" "5.03" "120.30" "9" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf12643" "79077" "ENSG00000179958" "DCTPP1" "hsa:79077; Q9H773" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "1.036" "0.949" "1.001" "1.004" "0.996" "1.018" "1.045" "0.984" "0.766" "1844.2" "1911.3" "1750.1" "1846.4" "1851.8" "1837.2" "1877.4" "1927.1" "1813.8" "1413.3" "" "" "" "" "" "" "" "" "" "" "1658.1" "1546.6" "1583.0" "1802.3" "1528.1" "1837.2" "1405.7" "1702.2" "1623.0" "504.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5058641913772226661" "False" "High" "IsMasterProtein" "Q68CJ6" "Nuclear GTPase SLIP-GC OS=Homo sapiens OX=9606 GN=NUGGC PE=1 SV=3" "0.000" "False" "60.917" "22" "17" "26" "17" "796" "91.1" "8.63" "88.10" "17" "other biological processes" "nucleus" "other molecular function" "Pf00350" "389643" "ENSG00000189233" "NUGGC" "hsa:389643; Q68CJ6; Q6ZP73" "" "" "0" "0" "1.002" "0.765" "0.944" "0.958" "0.718" "0.933" "0.941" "0.702" "1.032" "2239.5" "2243.5" "1713.6" "2113.9" "2145.7" "1608.4" "2088.8" "2106.3" "1572.7" "2310.1" "" "" "" "" "" "" "" "" "" "" "2013.5" "1815.3" "1550.0" "2063.5" "1770.7" "1608.4" "1564.1" "1860.5" "1407.2" "824.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8697682766688933342" "False" "High" "IsMasterProtein" "Q9GZZ1" "N-alpha-acetyltransferase 50 OS=Homo sapiens OX=9606 GN=NAA50 PE=1 SV=1" "0.000" "False" "60.761" "63" "11" "22" "11" "169" "19.4" "8.81" "80.52" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "80218" "ENSG00000121579" "NAA50" "D3DN74; hsa:80218; Q68DQ1; Q9GZZ1" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.001" "1.009" "1.006" "1.010" "0.973" "0.991" "1.038" "0.990" "0.813" "2125.8" "2127.9" "2145.9" "2138.2" "2147.8" "2067.7" "2106.6" "2206.3" "2104.9" "1727.5" "" "" "" "" "" "" "" "" "" "" "1911.3" "1721.8" "1941.1" "2087.1" "1772.4" "2067.7" "1577.4" "1948.7" "1883.5" "616.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1130211750852848646" "False" "High" "IsMasterProtein" "Q13404" "Ubiquitin-conjugating enzyme E2 variant 1 OS=Homo sapiens OX=9606 GN=UBE2V1 PE=1 SV=2" "0.000" "False" "60.701" "61" "9" "50" "4" "147" "16.5" "7.93" "169.58" "9" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00179" "387522; 7335" "ENSG00000244687" "UBE2V1" "E1P629; hsa:387522; hsa:7335; Q13403; Q13404; Q13532; Q5TGE0; Q5TGE3; Q96H34; Q9GZT0; Q9GZW1; Q9H4J3; Q9H4J4; Q9UKL1; Q9UM48; Q9UM49; Q9UM50" "IL-1 signaling pathway; Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Aggrephagy; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; activated TAK1 mediates p38 MAPK activation; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "19" "7" "0.978" "0.991" "0.995" "1.034" "0.958" "1.017" "1.030" "0.986" "0.824" "3794.6" "3710.0" "3760.9" "3777.2" "3923.6" "3635.1" "3857.4" "3906.7" "3740.4" "3126.8" "" "" "" "" "" "" "" "" "" "" "3411.7" "3002.0" "3401.9" "3687.0" "3237.8" "3635.1" "2888.3" "3450.7" "3346.9" "1116.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2946380844768102927" "False" "High" "IsMasterProtein" "Q96I24" "Far upstream element-binding protein 3 OS=Homo sapiens OX=9606 GN=FUBP3 PE=1 SV=2" "0.000" "False" "60.581" "35" "20" "36" "16" "572" "61.6" "8.38" "114.42" "20" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00013" "8939" "ENSG00000107164" "FUBP3" "A3KFK8; A3KFL0; hsa:8939; Q92946; Q96I24; Q9BVB6" "" "" "0" "0" "1.048" "1.061" "1.024" "1.049" "1.080" "1.049" "0.998" "1.013" "1.301" "1667.0" "1746.8" "1767.9" "1707.8" "1749.5" "1799.8" "1748.5" "1662.9" "1689.2" "2168.5" "" "" "" "" "" "" "" "" "" "" "1498.8" "1413.5" "1599.1" "1667.0" "1443.7" "1799.8" "1309.2" "1468.8" "1511.4" "774.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677465183251509063" "False" "High" "IsMasterProtein" "Q9NX55" "Huntingtin-interacting protein K OS=Homo sapiens OX=9606 GN=HYPK PE=1 SV=3" "0.000" "False" "60.539" "54" "6" "37" "6" "121" "13.6" "4.82" "126.93" "6" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf19026" "25764" "ENSG00000242028" "HYPK" "C9JKJ0; hsa:25764; O75408; Q8WUW8; Q9NX55; Q9P024" "" "" "0" "0" "0.932" "0.992" "0.972" "1.088" "1.003" "1.006" "1.002" "1.041" "0.858" "2297.2" "2142.0" "2278.7" "2233.4" "2498.7" "2303.5" "2310.6" "2300.8" "2390.5" "1972.1" "" "" "" "" "" "" "" "" "" "" "2065.4" "1733.2" "2061.2" "2180.1" "2062.0" "2303.5" "1730.1" "2032.2" "2139.0" "704.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919502417942593637" "False" "High" "IsMasterProtein" "A5A3E0" "POTE ankyrin domain family member F OS=Homo sapiens OX=9606 GN=POTEF PE=1 SV=2" "0.000" "False" "60.508" "11" "10" "250" "1" "1075" "121.4" "6.20" "844.41" "10" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022, Pf12796, Pf14915" "728378" "ENSG00000196604" "POTEF" "A5A3E0; A6NC34; hsa:728378" "" "" "0" "1" "0.976" "0.958" "1.104" "0.912" "1.177" "0.832" "0.904" "1.173" "0.655" "238.3" "232.6" "228.3" "263.0" "217.3" "280.6" "198.2" "215.5" "279.5" "156.1" "" "" "" "" "" "" "" "" "" "" "214.3" "188.2" "206.5" "256.8" "179.3" "280.6" "148.4" "190.4" "250.1" "55.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7915311945115274700" "False" "High" "IsMasterProtein" "O15212" "Prefoldin subunit 6 OS=Homo sapiens OX=9606 GN=PFDN6 PE=1 SV=1" "0.000" "False" "60.484" "52" "10" "30" "10" "129" "14.6" "8.88" "125.31" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "10471" "ENSG00000204220; ENSG00000206283; ENSG00000224782; ENSG00000235692; ENSG00000237335" "PFDN6" "hsa:10471; O15212" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.967" "0.952" "0.954" "0.952" "0.975" "0.958" "1.017" "0.959" "0.803" "3069.6" "2967.4" "2922.3" "2928.1" "2923.0" "2994.1" "2940.3" "3123.2" "2943.3" "2463.5" "" "" "" "" "" "" "" "" "" "" "2759.8" "2401.1" "2643.3" "2858.2" "2412.1" "2994.1" "2201.6" "2758.6" "2633.6" "879.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7690147936594120282" "False" "High" "IsMasterProtein" "P08397" "Porphobilinogen deaminase OS=Homo sapiens OX=9606 GN=HMBS PE=1 SV=2" "0.000" "False" "60.451" "46" "16" "20" "16" "361" "39.3" "7.18" "82.85" "16" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01379, Pf03900" "3145" "ENSG00000256269" "HMBS" "A8K2L0; G3V1P4; G5EA58; hsa:3145; P08396; P08397; Q16012" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.014" "0.976" "1.000" "1.063" "0.992" "1.016" "0.994" "0.996" "0.821" "1381.2" "1400.7" "1348.2" "1381.2" "1468.3" "1369.5" "1402.6" "1373.1" "1376.0" "1133.8" "" "" "" "" "" "" "" "" "" "" "1241.8" "1133.4" "1219.5" "1348.3" "1211.7" "1369.5" "1050.3" "1212.8" "1231.2" "404.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5757828644476711483" "False" "High" "IsMasterProtein" "Q9NXR1" "Nuclear distribution protein nudE homolog 1 OS=Homo sapiens OX=9606 GN=NDE1 PE=1 SV=3" "0.000" "False" "60.450" "51" "16" "25" "12" "335" "37.7" "5.15" "87.32" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "54820" "ENSG00000072864; ENSG00000275911" "NDE1" "hsa:54820; Q49AQ2; Q9NXR1" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "13" "3" "1.025" "1.028" "1.003" "1.017" "1.056" "1.043" "1.094" "1.036" "0.984" "2067.4" "2119.6" "2125.6" "2073.9" "2102.8" "2182.1" "2155.7" "2262.7" "2142.1" "2033.7" "" "" "" "" "" "" "" "" "" "" "1858.8" "1715.1" "1922.7" "2024.4" "1735.3" "2182.1" "1614.1" "1998.5" "1916.7" "726.0" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013273140133158732" "False" "High" "IsMasterProtein" "Q9H3P7" "Golgi resident protein GCP60 OS=Homo sapiens OX=9606 GN=ACBD3 PE=1 SV=4" "0.000" "False" "60.441" "26" "10" "17" "10" "528" "60.6" "5.06" "82.83" "10" "other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00887, Pf13897" "64746" "ENSG00000182827" "ACBD3" "B2RB29; hsa:64746; Q5VTJ0; Q6P9F1; Q8IZC5; Q8N4D6; Q9H3P7; Q9H6U3" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.960" "0.990" "1.073" "1.006" "1.117" "0.993" "1.024" "1.011" "0.962" "1301.9" "1250.0" "1288.8" "1396.5" "1309.7" "1454.3" "1292.5" "1333.2" "1316.5" "1252.0" "" "" "" "" "" "" "" "" "" "" "1170.6" "1011.4" "1165.7" "1363.2" "1080.8" "1454.3" "967.8" "1177.6" "1178.0" "446.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "76993751311903605" "False" "High" "IsMasterProtein" "Q9GZZ9" "Ubiquitin-like modifier-activating enzyme 5 OS=Homo sapiens OX=9606 GN=UBA5 PE=1 SV=1" "0.000" "False" "60.314" "32" "10" "22" "10" "404" "44.8" "4.84" "93.88" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00899" "79876" "ENSG00000081307" "UBA5" "A6NJL3; D3DNC8; hsa:79876; Q96ST1; Q9GZZ9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.966" "0.997" "1.024" "1.022" "0.975" "1.006" "1.014" "1.035" "0.860" "1429.1" "1380.7" "1424.4" "1464.0" "1460.5" "1393.9" "1437.2" "1448.8" "1479.0" "1228.8" "" "" "" "" "" "" "" "" "" "" "1284.9" "1117.2" "1288.4" "1429.1" "1205.3" "1393.9" "1076.2" "1279.7" "1323.4" "438.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824521577804774203" "False" "High" "IsMasterProtein" "Q53GS9" "Ubiquitin carboxyl-terminal hydrolase 39 OS=Homo sapiens OX=9606 GN=USP39 PE=1 SV=2" "0.000" "False" "60.259" "25" "14" "21" "14" "565" "65.3" "8.91" "88.68" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00443, Pf02148" "10713" "ENSG00000168883" "USP39" "A8K086; B3KM40; B4DHT4; D6W5L4; G5E9H0; hsa:10713; Q53GS9; Q6NX47; Q96RK9; Q9BV89; Q9H381; Q9P050; Q9Y310" "" "mRNA Splicing - Major Pathway" "1" "0" "0.995" "1.058" "0.977" "1.000" "1.075" "0.924" "0.958" "0.965" "0.631" "1998.3" "1988.9" "2113.7" "1953.2" "1998.6" "2148.6" "1846.0" "1915.3" "1928.7" "1261.1" "" "" "" "" "" "" "" "" "" "" "1796.6" "1609.3" "1911.9" "1906.6" "1649.3" "2148.6" "1382.2" "1691.7" "1725.8" "450.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-720179637671099041" "False" "High" "IsMasterProtein" "Q06546" "GA-binding protein alpha chain OS=Homo sapiens OX=9606 GN=GABPA PE=1 SV=1" "0.000" "False" "60.247" "38" "13" "15" "13" "454" "51.3" "4.97" "72.20" "13" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf11620" "2551" "ENSG00000154727" "GABPA" "hsa:2551; Q06546; Q12939" "Energy metabolism; Allograft rejection; Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression; Pleural mesothelioma" "Transcriptional activation of mitochondrial biogenesis" "7" "0" "0.993" "1.018" "0.968" "1.005" "0.959" "1.038" "0.966" "1.032" "1.842" "1119.7" "1112.3" "1140.4" "1083.8" "1125.1" "1073.6" "1161.8" "1081.3" "1155.2" "2063.0" "" "" "" "" "" "" "" "" "" "" "1006.7" "900.1" "1031.5" "1057.9" "928.5" "1073.6" "869.9" "955.1" "1033.7" "736.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4100918330742864628" "False" "High" "IsMasterProtein" "Q96GK7" "Oxaloacetate tautomerase FAHD2A, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD2A PE=1 SV=1" "0.000" "False" "60.218" "38" "10" "29" "10" "314" "34.6" "8.24" "109.64" "10" "" "" "other molecular function" "Pf01557" "51011" "ENSG00000115042; ENSG00000292086" "FAHD2A" "hsa:51011; Q96GK7; Q9Y3B0" "" "" "0" "0" "0.990" "0.974" "0.966" "0.975" "0.921" "0.995" "1.001" "0.948" "0.787" "1848.9" "1829.7" "1801.3" "1785.6" "1801.8" "1703.5" "1839.0" "1850.9" "1753.6" "1455.9" "" "" "" "" "" "" "" "" "" "" "1662.3" "1480.5" "1629.4" "1743.0" "1486.9" "1703.5" "1377.0" "1634.8" "1569.1" "519.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240907950946080993" "False" "High" "IsMasterProtein" "Q9BV44" "tRNA (guanine(6)-N2)-methyltransferase THUMP3 OS=Homo sapiens OX=9606 GN=THUMPD3 PE=1 SV=1" "0.000" "False" "60.186" "28" "15" "25" "15" "507" "57.0" "6.37" "84.80" "15" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01170, Pf02926" "25917" "ENSG00000134077" "THUMPD3" "hsa:25917; Q9BV44; Q9H8V6; Q9NVC1; Q9UFS3" "" "" "0" "0" "1.046" "1.038" "0.965" "1.037" "0.962" "0.989" "0.990" "1.000" "0.830" "1908.5" "1997.1" "1981.8" "1842.3" "1979.9" "1836.2" "1888.4" "1890.3" "1908.6" "1583.5" "" "" "" "" "" "" "" "" "" "" "1715.9" "1616.0" "1792.6" "1798.4" "1633.9" "1836.2" "1414.0" "1669.6" "1707.8" "565.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3533689105478908948" "False" "High" "IsMasterProtein" "Q15369" "Elongin-C OS=Homo sapiens OX=9606 GN=ELOC PE=1 SV=1" "0.000" "False" "60.109" "66" "7" "31" "7" "112" "12.5" "4.78" "125.29" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03931" "6921" "ENSG00000154582" "ELOC" "E5RGD9; hsa:6921; Q15369; Q567Q6" "Dual hijack model of Vif in HIV infection; VEGFA-VEGFR2 signaling; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of expression of SLITs and ROBOs; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses" "22" "0" "0.927" "0.984" "1.038" "1.002" "0.966" "0.961" "1.036" "1.065" "0.831" "2362.8" "2190.3" "2325.4" "2453.7" "2368.0" "2283.4" "2269.8" "2446.8" "2516.3" "1964.6" "" "" "" "" "" "" "" "" "" "" "2124.4" "1772.3" "2103.4" "2395.2" "1954.1" "2283.4" "1699.6" "2161.2" "2251.6" "701.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980690536672084448" "False" "High" "IsMasterProtein" "Q8NHV4" "Protein NEDD1 OS=Homo sapiens OX=9606 GN=NEDD1 PE=1 SV=1" "0.000" "False" "60.041" "24" "13" "17" "13" "660" "71.9" "7.97" "75.85" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "121441" "ENSG00000139350" "NEDD1" "B0AZN0; B4E145; G3V3F1; hsa:121441; Q8NA30; Q8NHV4" "" "Regulation of PLK1 Activity at G2/M Transition; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.066" "1.075" "0.985" "1.008" "1.036" "1.096" "0.982" "1.009" "0.909" "2288.4" "2438.8" "2459.0" "2254.4" "2306.6" "2371.8" "2509.1" "2246.6" "2309.2" "2079.3" "" "" "" "" "" "" "" "" "" "" "2057.5" "1973.4" "2224.3" "2200.6" "1903.4" "2371.8" "1878.8" "1984.3" "2066.2" "742.3" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5466542288326959120" "False" "High" "IsMasterProtein" "P59998" "Actin-related protein 2/3 complex subunit 4 OS=Homo sapiens OX=9606 GN=ARPC4 PE=1 SV=3" "0.000" "False" "60.015" "67" "11" "34" "11" "168" "19.7" "8.43" "131.24" "11" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05856" "10093" "ENSG00000241553" "ARPC4" "C9JWM7; E7ETI0; F6TTL5; hsa:10093; O15509; P59998; Q6P0W5; Q96QJ3" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.038" "1.046" "1.036" "1.058" "1.029" "1.032" "1.049" "1.059" "0.831" "3015.2" "3128.2" "3153.8" "3123.4" "3190.5" "3103.6" "3110.5" "3161.9" "3192.9" "2506.4" "" "" "" "" "" "" "" "" "" "" "2710.9" "2531.3" "2852.7" "3048.8" "2632.8" "3103.6" "2329.1" "2792.8" "2856.9" "894.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155444033397587021" "False" "High" "IsMasterProtein" "Q06265" "Exosome complex component RRP45 OS=Homo sapiens OX=9606 GN=EXOSC9 PE=1 SV=3" "0.000" "False" "60.007" "30" "11" "18" "11" "439" "48.9" "5.29" "73.37" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "5393" "ENSG00000123737" "EXOSC9" "hsa:5393; Q06265; Q12883; Q4W5P5; Q86Y41; Q86Y48" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.048" "1.073" "0.983" "1.104" "1.039" "1.015" "1.015" "1.102" "0.665" "2133.1" "2235.0" "2289.0" "2097.7" "2354.3" "2215.8" "2166.1" "2165.3" "2350.8" "1418.4" "" "" "" "" "" "" "" "" "" "" "1917.9" "1808.5" "2070.5" "2047.6" "1942.8" "2215.8" "1621.9" "1912.5" "2103.5" "506.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822975009015350041" "False" "High" "IsMasterProtein" "P60228" "Eukaryotic translation initiation factor 3 subunit E OS=Homo sapiens OX=9606 GN=EIF3E PE=1 SV=1" "0.000" "False" "59.998" "32" "14" "25" "14" "445" "52.2" "6.04" "79.60" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01399, Pf09440, Pf21357" "3646" "ENSG00000104408" "EIF3E" "hsa:3646; O43902; P60228; Q64058; Q64059; Q64252; Q6FG33; Q8WVK4" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "8" "0" "1.039" "0.967" "0.917" "0.993" "0.986" "0.985" "0.928" "1.007" "1.879" "1984.7" "2062.0" "1918.9" "1819.6" "1971.0" "1956.2" "1954.9" "1842.0" "1998.2" "3729.2" "" "" "" "" "" "" "" "" "" "" "1784.4" "1668.5" "1735.7" "1776.2" "1626.5" "1956.2" "1463.8" "1626.9" "1788.0" "1331.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7438852567896609676" "False" "High" "IsMasterProtein" "Q7L5N1" "COP9 signalosome complex subunit 6 OS=Homo sapiens OX=9606 GN=COPS6 PE=1 SV=1" "0.000" "False" "59.995" "48" "11" "21" "11" "327" "36.1" "5.73" "89.80" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01398, Pf13012" "10980" "ENSG00000168090" "COPS6" "A4D2A3; hsa:10980; O15387; Q7L5N1" "Nucleotide-binding oligomerization domain (NOD) pathway; Ciliary landscape" "Neddylation; Formation of TC-NER Pre-Incision Complex; Cargo recognition for clathrin-mediated endocytosis; DNA Damage Recognition in GG-NER" "6" "0" "1.023" "1.039" "0.967" "1.036" "1.047" "1.013" "1.024" "1.066" "0.936" "1921.3" "1965.8" "1996.9" "1858.0" "1990.4" "2010.7" "1946.6" "1966.5" "2047.3" "1797.8" "" "" "" "" "" "" "" "" "" "" "1727.4" "1590.7" "1806.3" "1813.7" "1642.5" "2010.7" "1457.6" "1736.9" "1831.9" "641.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4621514541592481866" "False" "High" "IsMasterProtein" "O75376" "Nuclear receptor corepressor 1 OS=Homo sapiens OX=9606 GN=NCOR1 PE=1 SV=2" "0.000" "False" "59.953" "7" "18" "21" "17" "2440" "270.0" "7.11" "75.78" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9611" "ENSG00000141027" "NCOR1" "B3DLF8; E9PGV6; hsa:9611; O75376; Q86YY0; Q9UPV5; Q9UQ18" "Androgen receptor signaling pathway; Adipogenesis; Ovarian infertility; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Rett syndrome; 22q11.2 copy number variation syndrome; Notch signaling pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Nuclear signaling by ERBB4; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NR1D1 (REV-ERBA) represses gene expression; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "30" "0" "1.028" "1.023" "1.008" "1.059" "0.996" "1.076" "0.999" "0.941" "1.159" "1387.2" "1425.4" "1419.5" "1399.0" "1469.0" "1381.8" "1492.9" "1385.9" "1305.9" "1607.3" "" "" "" "" "" "" "" "" "" "" "1247.3" "1153.4" "1284.0" "1365.6" "1212.2" "1381.8" "1117.8" "1224.1" "1168.5" "573.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8349989266333908893" "False" "High" "IsMasterProtein" "P49841" "Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2" "0.000" "False" "59.883" "45" "16" "21" "10" "420" "46.7" "8.78" "88.83" "16" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2932" "ENSG00000082701" "GSK3B" "D3DN89; hsa:2932; P49841; Q9BWH3; Q9UL47" "IL-5 signaling pathway; Androgen receptor signaling pathway; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Focal adhesion; Copper homeostasis; Melatonin metabolism and effects; Wnt signaling pathway; IL6 signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Wnt signaling pathway and pluripotency; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Acute viral myocarditis; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Influence of laminopathies on Wnt signaling; MAP3K1 role in promoting and blocking gonadal determination; Overlap between signal transduction pathways contributing to LMNA laminopathies; Glycogen synthesis and degradation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Neurogenesis regulation in the olfactory epithelium; Sildenafil treatment; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; Notch signaling pathway; ErbB signaling pathway; DNA damage response (only ATM dependent)" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Ubiquitin-dependent degradation of Cyclin D; Regulation of RUNX2 expression and activity; Regulation of HSF1-mediated heat shock response; Constitutive Signaling by AKT1 E17K in Cancer; B-WICH complex positively regulates rRNA expression; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; CRMPs in Sema3A signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; AKT phosphorylates targets in the cytosol; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein; Maturation of nucleoprotein" "95" "7" "0.959" "0.985" "1.007" "0.999" "0.966" "0.972" "1.009" "0.969" "0.887" "2220.1" "2129.0" "2186.1" "2235.8" "2217.6" "2145.6" "2158.8" "2241.0" "2151.7" "1969.4" "" "" "" "" "" "" "" "" "" "" "1996.1" "1722.7" "1977.4" "2182.5" "1830.0" "2145.6" "1616.4" "1979.4" "1925.3" "703.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1817111684576735415" "False" "High" "IsMasterProtein" "O15511" "Actin-related protein 2/3 complex subunit 5 OS=Homo sapiens OX=9606 GN=ARPC5 PE=1 SV=3" "0.000" "False" "59.874" "66" "9" "31" "9" "151" "16.3" "5.67" "135.55" "9" "cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04699" "10092" "ENSG00000162704" "ARPC5" "A6NEC4; hsa:10092; O15511; Q6PG42" "Pathogenic Escherichia coli infection; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Neutrophil degranulation; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "8" "0" "0.926" "0.935" "1.001" "0.981" "1.083" "0.993" "1.078" "0.968" "0.918" "3036.4" "2811.0" "2838.7" "3040.5" "2979.2" "3289.4" "3014.7" "3274.5" "2939.3" "2788.6" "" "" "" "" "" "" "" "" "" "" "2730.0" "2274.6" "2567.7" "2967.9" "2458.5" "3289.4" "2257.3" "2892.3" "2630.0" "995.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "960640284500961057" "False" "High" "IsMasterProtein" "Q13426" "DNA repair protein XRCC4 OS=Homo sapiens OX=9606 GN=XRCC4 PE=1 SV=2" "0.000" "False" "59.868" "57" "15" "22" "15" "336" "38.3" "4.98" "75.90" "15" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06632" "7518" "ENSG00000152422" "XRCC4" "A8K3X4; hsa:7518; Q13426; Q9BS72; Q9UP94" "Non-homologous end joining; Male infertility; DNA repair pathways, full network; Primary ovarian insufficiency" "SUMOylation of DNA damage response and repair proteins; Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "7" "0" "1.023" "1.021" "1.106" "0.976" "1.035" "0.988" "1.015" "1.036" "0.799" "1212.9" "1240.4" "1238.5" "1341.9" "1183.6" "1255.7" "1198.5" "1230.6" "1256.0" "969.6" "" "" "" "" "" "" "" "" "" "" "1090.5" "1003.7" "1120.2" "1309.9" "976.7" "1255.7" "897.4" "1086.9" "1123.9" "346.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "609844474726423505" "False" "High" "IsMasterProtein" "P63279" "SUMO-conjugating enzyme UBC9 OS=Homo sapiens OX=9606 GN=UBE2I PE=1 SV=1" "0.000" "False" "59.792" "53" "7" "30" "7" "158" "18.0" "8.66" "119.88" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7329" "ENSG00000103275" "UBE2I" "D3DU69; P50550; P63279; Q15698; Q59GX1; Q86VB3" "Androgen receptor signaling pathway; TGF-beta signaling pathway; TAR syndrome" "Meiotic synapsis; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; PKR-mediated signaling; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; Vitamin D (calciferol) metabolism; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Formation of Incision Complex in GG-NER; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "27" "0" "0.983" "1.000" "1.017" "1.026" "0.953" "1.057" "1.025" "0.996" "0.873" "3277.4" "3222.1" "3278.0" "3334.5" "3362.4" "3122.5" "3464.1" "3357.9" "3264.8" "2861.6" "" "" "" "" "" "" "" "" "" "" "2946.7" "2607.2" "2965.0" "3254.9" "2774.7" "3122.5" "2593.8" "2965.9" "2921.3" "1021.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-693009755778798309" "False" "High" "IsMasterProtein" "O75396" "Vesicle-trafficking protein SEC22b OS=Homo sapiens OX=9606 GN=SEC22B PE=1 SV=5" "0.000" "False" "59.785" "38" "7" "18" "7" "215" "24.7" "8.51" "78.04" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00957, Pf13774" "9554" "ENSG00000265808" "SEC22B" "A8K1G0; hsa:9554; O75396" "" "COPI-dependent Golgi-to-ER retrograde traffic; ER-Phagosome pathway; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "0.920" "0.892" "0.998" "0.970" "0.903" "0.996" "0.963" "0.893" "0.588" "2326.9" "2140.7" "2076.7" "2322.2" "2257.5" "2101.6" "2317.7" "2240.2" "2078.8" "1369.2" "" "" "" "" "" "" "" "" "" "" "2092.1" "1732.2" "1878.4" "2266.8" "1862.9" "2101.6" "1735.4" "1978.7" "1860.1" "488.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5023215591343920566" "False" "High" "IsMasterProtein" "Q12768" "WASH complex subunit 5 OS=Homo sapiens OX=9606 GN=WASHC5 PE=1 SV=1" "0.000" "False" "59.662" "18" "19" "22" "19" "1159" "134.2" "6.98" "66.22" "19" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf10266" "9897" "ENSG00000164961" "WASHC5" "A8K4R7; hsa:9897; Q12768; Q3KQX5; Q8TBQ2" "" "" "0" "0" "0.999" "0.957" "0.937" "0.973" "0.893" "0.988" "0.966" "0.946" "1.176" "1307.0" "1306.1" "1250.2" "1224.2" "1272.1" "1167.0" "1291.4" "1262.3" "1236.0" "1537.7" "" "" "" "" "" "" "" "" "" "" "1175.1" "1056.8" "1130.8" "1195.0" "1049.7" "1167.0" "966.9" "1115.0" "1106.0" "548.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8198800325193539681" "False" "High" "IsMasterProtein" "P30050" "Large ribosomal subunit protein uL11 OS=Homo sapiens OX=9606 GN=RPL12 PE=1 SV=1" "0.000" "False" "59.641" "64" "8" "26" "8" "165" "17.8" "9.42" "100.64" "8" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "6136" "ENSG00000197958" "RPL12" "hsa:6136; P30050; Q5VVV2; Q6PB27" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.084" "0.941" "0.988" "1.171" "1.038" "1.091" "1.235" "0.886" "0.528" "2363.5" "2561.9" "2223.1" "2334.3" "2767.0" "2452.4" "2577.6" "2918.5" "2093.2" "1248.1" "" "" "" "" "" "" "" "" "" "" "2125.0" "2073.0" "2010.9" "2278.6" "2283.3" "2452.4" "1930.1" "2577.8" "1873.0" "445.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002494153914850513" "False" "High" "IsMasterProtein" "P51665" "26S proteasome non-ATPase regulatory subunit 7 OS=Homo sapiens OX=9606 GN=PSMD7 PE=1 SV=2" "0.000" "False" "59.600" "44" "10" "23" "10" "324" "37.0" "6.77" "91.29" "10" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01398, Pf13012" "5713" "ENSG00000103035" "PSMD7" "D3DWS9; hsa:5713; P51665; Q6PKI2; Q96E97" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Orc1 removal from chromatin; Assembly of the pre-replicative complex; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "65" "0" "1.013" "1.012" "1.006" "1.074" "1.038" "1.060" "1.077" "1.084" "0.859" "1386.4" "1404.6" "1402.9" "1395.2" "1489.4" "1439.2" "1470.2" "1493.3" "1503.2" "1190.7" "" "" "" "" "" "" "" "" "" "" "1246.5" "1136.5" "1269.0" "1361.9" "1229.1" "1439.2" "1100.8" "1319.0" "1345.1" "425.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8858852225098701208" "False" "High" "IsMasterProtein" "P49642" "DNA primase small subunit OS=Homo sapiens OX=9606 GN=PRIM1 PE=1 SV=1" "0.000" "False" "59.376" "33" "12" "18" "12" "420" "49.9" "8.21" "62.36" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf01896" "5557" "ENSG00000198056" "PRIM1" "hsa:5557; P49642" "Retinoblastoma gene in cancer; Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "13" "0" "1.037" "1.001" "0.987" "1.008" "0.880" "1.036" "0.970" "0.963" "1.579" "1152.3" "1194.9" "1153.7" "1137.3" "1161.8" "1013.9" "1193.7" "1118.2" "1109.6" "1819.0" "" "" "" "" "" "" "" "" "" "" "1036.1" "966.8" "1043.6" "1110.1" "958.8" "1013.9" "893.8" "987.7" "992.9" "649.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331703410720076251" "False" "High" "IsMasterProtein" "Q96BN8" "Ubiquitin thioesterase otulin OS=Homo sapiens OX=9606 GN=OTULIN PE=1 SV=3" "0.000" "False" "59.353" "43" "14" "23" "14" "352" "40.2" "5.47" "84.30" "14" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16218" "90268" "ENSG00000154124" "OTULIN" "D3DTD3; hsa:90268; Q8NAS0; Q96BN8; Q96IA3" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Regulation of TNFR1 signaling" "2" "0" "1.006" "1.027" "0.988" "0.990" "0.967" "1.051" "0.993" "0.981" "1.268" "1665.6" "1675.5" "1710.6" "1646.4" "1648.5" "1610.9" "1750.2" "1654.1" "1634.6" "2112.7" "" "" "" "" "" "" "" "" "" "" "1497.6" "1355.7" "1547.3" "1607.1" "1360.4" "1610.9" "1310.5" "1461.0" "1462.7" "754.2" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4218486089971029806" "False" "High" "IsMasterProtein" "Q92608" "Dedicator of cytokinesis protein 2 OS=Homo sapiens OX=9606 GN=DOCK2 PE=1 SV=2" "0.000" "False" "59.321" "10" "18" "20" "16" "1830" "211.8" "6.87" "64.59" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06920, Pf07653, Pf14429, Pf16172, Pf20421, Pf20422" "1794" "ENSG00000134516" "DOCK2" "hsa:1794; Q2M3I0; Q92608; Q96AK7" "Chemokine signaling pathway" "RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Neutrophil degranulation; Factors involved in megakaryocyte development and platelet production; Nef and signal transduction" "8" "1" "1.015" "1.026" "0.980" "1.034" "1.035" "1.068" "0.955" "1.070" "4.369" "941.2" "955.7" "966.0" "922.0" "973.5" "974.0" "1005.3" "898.9" "1007.2" "4112.4" "" "" "" "" "" "" "" "" "" "" "846.2" "773.3" "873.8" "900.0" "803.3" "974.0" "752.7" "794.0" "901.2" "1468.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6631585726403495176" "False" "High" "IsMasterProtein" "O14787" "Transportin-2 OS=Homo sapiens OX=9606 GN=TNPO2 PE=1 SV=3" "0.000" "False" "59.314" "19" "15" "22" "8" "897" "101.3" "5.01" "74.23" "15" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf03810" "30000" "ENSG00000105576" "TNPO2" "hsa:30000; O14655; O14787; Q6IN77" "" "" "0" "0" "1.028" "0.996" "0.960" "1.027" "0.891" "1.021" "0.963" "0.969" "1.640" "880.7" "905.6" "877.6" "845.4" "904.1" "784.4" "899.2" "847.7" "853.5" "1444.2" "" "" "" "" "" "" "" "" "" "" "791.8" "732.8" "793.8" "825.2" "746.1" "784.4" "673.3" "748.8" "763.7" "515.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5978569898189539548" "False" "High" "IsMasterProtein" "O75694" "Nuclear pore complex protein Nup155 OS=Homo sapiens OX=9606 GN=NUP155 PE=1 SV=1" "0.000" "False" "59.281" "14" "15" "17" "15" "1391" "155.1" "6.16" "64.35" "15" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf08801" "9631" "ENSG00000113569" "NUP155" "hsa:9631; O75694; Q9UBE9; Q9UFL5" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "1.046" "1.041" "0.943" "0.994" "1.038" "1.027" "0.920" "1.042" "1.095" "1164.8" "1218.5" "1212.8" "1098.8" "1157.8" "1209.5" "1196.8" "1072.0" "1214.3" "1275.7" "" "" "" "" "" "" "" "" "" "" "1047.3" "986.0" "1097.0" "1072.6" "955.5" "1209.5" "896.1" "946.9" "1086.5" "455.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7748730165992048021" "False" "High" "IsMasterProtein" "Q6UWE0" "E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens OX=9606 GN=LRSAM1 PE=1 SV=1" "0.000" "False" "59.166" "20" "13" "17" "13" "723" "83.5" "5.94" "61.06" "13" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf07647, Pf13855, Pf13920" "90678" "ENSG00000148356" "LRSAM1" "Q5VVV0; Q6UWE0; Q8NB40; Q96GT5; Q96MX5; Q96MZ7" "Intracellular trafficking proteins involved in CMT neuropathy" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.140" "1.131" "1.071" "1.093" "1.160" "1.081" "1.157" "1.160" "0.922" "346.6" "395.0" "391.9" "371.3" "378.9" "401.9" "374.7" "401.0" "401.9" "319.5" "" "" "" "" "" "" "" "" "" "" "311.6" "319.6" "354.5" "362.4" "312.7" "401.9" "280.6" "354.2" "359.7" "114.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3450396974392384393" "False" "High" "IsMasterProtein" "Q13112" "Chromatin assembly factor 1 subunit B OS=Homo sapiens OX=9606 GN=CHAF1B PE=1 SV=1" "0.000" "False" "59.164" "30" "15" "25" "15" "559" "61.5" "7.50" "89.29" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf00400, Pf15512" "8208" "ENSG00000159259" "CHAF1B" "hsa:8208; Q13112; Q99548" "" "" "0" "0" "1.011" "1.065" "0.949" "1.045" "1.098" "1.040" "1.043" "1.124" "0.917" "2010.3" "2032.0" "2141.7" "1908.6" "2101.4" "2206.8" "2089.8" "2097.5" "2260.0" "1842.7" "" "" "" "" "" "" "" "" "" "" "1807.5" "1644.2" "1937.3" "1863.1" "1734.1" "2206.8" "1564.8" "1852.6" "2022.2" "657.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8321429417116917544" "False" "High" "IsMasterProtein" "P07339" "Cathepsin D OS=Homo sapiens OX=9606 GN=CTSD PE=1 SV=1" "0.000" "False" "59.088" "38" "11" "19" "11" "412" "44.5" "6.54" "72.28" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00026, Pf07966" "1509" "ENSG00000117984" "CTSD" "hsa:1509; P07339; Q6IB57" "Prolactin signaling pathway; 8p23.1 copy number variation syndrome" "Neutrophil degranulation; MHC class II antigen presentation; Collagen degradation; Estrogen-dependent gene expression; Insulin receptor recycling; Metabolism of Angiotensinogen to Angiotensins" "8" "0" "1.003" "0.979" "0.978" "1.037" "0.936" "0.974" "1.019" "1.052" "0.811" "982.1" "985.3" "961.2" "960.8" "1018.2" "919.6" "956.5" "1001.1" "1032.8" "796.4" "" "" "" "" "" "" "" "" "" "" "883.0" "797.3" "869.4" "937.8" "840.2" "919.6" "716.2" "884.3" "924.1" "284.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2502404100025205194" "False" "High" "IsMasterProtein" "P27824" "Calnexin OS=Homo sapiens OX=9606 GN=CANX PE=1 SV=2" "0.000" "False" "59.081" "27" "17" "19" "17" "592" "67.5" "4.60" "74.73" "17" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00262" "821" "ENSG00000127022; ENSG00000283777" "CANX" "B2R5V8; B4DGP8; B4E2T8; D3DWQ3; D6R9K3; hsa:821; P27824" "15q11q13 copy number variation" "MHC class II antigen presentation; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Interleukin-35 Signalling; Interleukin-27 signaling; Assembly of Viral Components at the Budding Site; Maturation of spike protein; Calnexin/calreticulin cycle; Maturation of spike protein" "9" "0" "0.907" "0.841" "0.962" "0.915" "0.874" "1.041" "0.930" "0.906" "1.141" "1901.9" "1724.6" "1599.2" "1828.7" "1739.8" "1661.5" "1980.2" "1769.6" "1722.6" "2170.1" "" "" "" "" "" "" "" "" "" "" "1710.0" "1395.5" "1446.6" "1785.1" "1435.7" "1661.5" "1482.8" "1563.0" "1541.4" "774.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3146791204946970239" "False" "High" "IsMasterProtein" "Q9Y6W5" "Actin-binding protein WASF2 OS=Homo sapiens OX=9606 GN=WASF2 PE=1 SV=3" "0.000" "False" "59.049" "30" "15" "31" "15" "498" "54.3" "5.53" "102.58" "15" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "10163" "ENSG00000158195" "WASF2" "B4DZN0; hsa:10163; O60794; Q9UDY7; Q9Y6W5" "Regulation of actin cytoskeleton" "RAC1 GTPase cycle; RAC2 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "8" "0" "1.036" "0.996" "1.007" "1.043" "0.982" "1.051" "1.056" "1.036" "0.837" "2539.8" "2631.0" "2530.6" "2556.7" "2648.2" "2495.0" "2668.2" "2681.2" "2631.5" "2125.9" "" "" "" "" "" "" "" "" "" "" "2283.5" "2128.9" "2289.0" "2495.7" "2185.3" "2495.0" "1997.9" "2368.2" "2354.6" "758.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5021829867861972309" "False" "High" "IsMasterProtein" "Q14671" "Pumilio homolog 1 OS=Homo sapiens OX=9606 GN=PUM1 PE=1 SV=3" "0.000" "False" "58.990" "12" "13" "23" "9" "1186" "126.4" "6.84" "75.25" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "9698" "ENSG00000134644" "PUM1" "A8K6W4; B4DG92; D3DPN3; E9PCJ0; hsa:9698; Q14671; Q53HH5; Q5VXY7; Q9HAN1" "" "Golgi Associated Vesicle Biogenesis" "1" "4" "0.968" "0.936" "0.995" "0.972" "0.931" "0.958" "0.977" "0.970" "0.954" "2102.3" "2035.9" "1967.9" "2092.8" "2044.3" "1956.8" "2014.2" "2053.4" "2039.9" "2005.1" "" "" "" "" "" "" "" "" "" "" "1890.2" "1647.4" "1780.1" "2042.8" "1687.0" "1956.8" "1508.2" "1813.7" "1825.3" "715.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8303897606251246511" "False" "High" "IsMasterProtein" "Q96HW7" "Integrator complex subunit 4 OS=Homo sapiens OX=9606 GN=INTS4 PE=1 SV=2" "0.000" "False" "58.936" "23" "19" "19" "19" "963" "108.1" "6.44" "61.89" "19" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13646, Pf20168" "92105" "ENSG00000149262" "INTS4" "hsa:92105; Q2YD62; Q6PJG4; Q7Z4E7; Q96G32; Q96GA1; Q96HW7; Q9BRC0" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.090" "1.030" "0.905" "1.033" "1.036" "1.039" "1.001" "0.993" "0.945" "1030.7" "1123.1" "1061.3" "933.0" "1064.8" "1067.6" "1070.5" "1031.8" "1023.5" "973.7" "" "" "" "" "" "" "" "" "" "" "926.7" "908.8" "959.9" "910.7" "878.7" "1067.6" "801.5" "911.4" "915.9" "347.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3718906404474103384" "False" "High" "IsMasterProtein" "P19174" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens OX=9606 GN=PLCG1 PE=1 SV=1" "0.000" "False" "58.920" "15" "17" "20" "17" "1290" "148.4" "6.05" "69.56" "17" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00387, Pf00388" "5335" "ENSG00000124181" "PLCG1" "B7ZLY7; B9EGH4; E1P5W4; hsa:5335; P19174; Q2V575" "Angiogenesis; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; PDGF pathway; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; MFAP5-mediated ovarian cancer cell motility and invasiveness; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; GPR40 pathway; PDGFR-beta pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-small cell lung cancer; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; ErbB signaling pathway; T-cell receptor signaling pathway" "ISG15 antiviral mechanism; Generation of second messenger molecules; Role of phospholipids in phagocytosis; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Signaling by ALK fusions and activated point mutants; RET signaling; Downstream signal transduction; Signaling by ALK; DAP12 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; EGFR interacts with phospholipase C-gamma; Signaling by FGFR1 in disease; Synthesis of IP3 and IP4 in the cytosol; Phospholipase C-mediated cascade: FGFR1; Phospholipase C-mediated cascade; FGFR2; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Phospholipase C-mediated cascade; FGFR3; Phospholipase C-mediated cascade; FGFR4; Signaling by FGFR3 in disease; DAG and IP3 signaling; Erythropoietin activates Phospholipase C gamma (PLCG); Role of second messengers in netrin-1 signaling; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; PLCG1 events in ERBB2 signaling; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; PLC-gamma1 signalling; PECAM1 interactions; Activated NTRK2 signals through PLCG1; Activated NTRK3 signals through PLCG1" "76" "0" "0.943" "0.979" "0.971" "0.908" "0.917" "0.990" "0.891" "0.890" "1.710" "1405.1" "1325.3" "1375.7" "1364.5" "1275.4" "1288.1" "1391.4" "1252.3" "1250.8" "2403.3" "" "" "" "" "" "" "" "" "" "" "1263.3" "1072.4" "1244.3" "1332.0" "1052.5" "1288.1" "1041.8" "1106.1" "1119.2" "857.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7644336301377244123" "False" "High" "IsMasterProtein" "Q8IZ83" "Aldehyde dehydrogenase family 16 member A1 OS=Homo sapiens OX=9606 GN=ALDH16A1 PE=1 SV=2" "0.000" "False" "58.823" "20" "13" "19" "13" "802" "85.1" "6.79" "70.76" "13" "" "" "other molecular function" "Pf00171" "126133" "ENSG00000161618" "ALDH16A1" "B4DLQ1; C9JBH6; hsa:126133; Q86YF0; Q8IYL4; Q8IZ83; Q8TEI8" "" "" "0" "0" "1.048" "1.099" "1.024" "1.080" "1.088" "1.027" "1.041" "1.113" "0.904" "1404.0" "1471.5" "1542.4" "1437.0" "1515.7" "1527.5" "1441.2" "1461.8" "1562.0" "1268.5" "" "" "" "" "" "" "" "" "" "" "1262.3" "1190.7" "1395.2" "1402.7" "1250.8" "1527.5" "1079.2" "1291.2" "1397.7" "452.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3912553749902594293" "False" "High" "IsMasterProtein" "P15880" "Small ribosomal subunit protein uS5 OS=Homo sapiens OX=9606 GN=RPS2 PE=1 SV=2" "0.000" "False" "58.794" "46" "14" "26" "14" "293" "31.3" "10.24" "80.67" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00333, Pf03719" "6187" "ENSG00000140988; ENSG00000291931" "RPS2" "B2R5G0; D3DU82; hsa:6187; P15880; Q3MIB1" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; RMTs methylate histone arginines; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Protein methylation; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "22" "0" "0.939" "0.995" "0.929" "0.920" "0.996" "0.922" "0.855" "0.981" "1.166" "2577.0" "2420.9" "2563.5" "2394.0" "2370.4" "2566.3" "2377.1" "2204.4" "2527.0" "3005.6" "" "" "" "" "" "" "" "" "" "" "2317.0" "1958.9" "2318.8" "2336.9" "1956.1" "2566.3" "1779.9" "1947.1" "2261.1" "1072.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3946682035619075212" "False" "High" "IsMasterProtein" "Q00688" "Peptidyl-prolyl cis-trans isomerase FKBP3 OS=Homo sapiens OX=9606 GN=FKBP3 PE=1 SV=1" "0.000" "False" "58.787" "51" "10" "34" "10" "224" "25.2" "9.28" "130.53" "10" "" "nucleus" "other molecular function" "Pf00254, Pf18410" "2287" "ENSG00000100442" "FKBP3" "B2R4Q9; hsa:2287; Q00688; Q14317" "" "" "0" "0" "0.915" "0.979" "0.991" "0.964" "1.001" "0.972" "1.015" "1.033" "0.854" "3658.4" "3349.2" "3583.0" "3624.6" "3526.2" "3663.6" "3557.4" "3714.5" "3778.6" "3125.8" "" "" "" "" "" "" "" "" "" "" "3289.3" "2710.1" "3241.0" "3538.1" "2909.9" "3663.6" "2663.7" "3280.9" "3381.1" "1115.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4039607230823659526" "False" "High" "IsMasterProtein" "P42025" "Beta-centractin OS=Homo sapiens OX=9606 GN=ACTR1B PE=1 SV=1" "0.000" "False" "58.779" "29" "9" "25" "4" "376" "42.3" "6.40" "86.21" "9" "" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00022" "10120" "ENSG00000115073; ENSG00000291597" "ACTR1B" "D3DVH2; hsa:10120; P42025; Q53SK5; Q9BRB7" "" "Neutrophil degranulation; MHC class II antigen presentation" "2" "0" "1.046" "1.068" "1.041" "1.063" "1.070" "1.104" "1.040" "1.087" "0.898" "290.1" "303.4" "309.8" "301.9" "308.3" "310.5" "320.2" "301.7" "315.2" "260.5" "" "" "" "" "" "" "" "" "" "" "260.8" "245.5" "280.2" "294.7" "254.4" "310.5" "239.7" "266.5" "282.0" "93.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3997402182379015815" "False" "High" "IsMasterProtein" "O15371" "Eukaryotic translation initiation factor 3 subunit D OS=Homo sapiens OX=9606 GN=EIF3D PE=1 SV=1" "0.000" "False" "58.738" "28" "12" "21" "12" "548" "63.9" "6.05" "81.90" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf05091" "8664" "ENSG00000100353" "EIF3D" "A8MWD3; B2R7D4; B4DTF8; B4DVY1; hsa:8664; O15371; Q3MJD9; Q5M9Q6" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "0.967" "0.998" "0.984" "0.979" "0.985" "0.961" "0.898" "0.999" "2.181" "1378.0" "1333.1" "1375.9" "1356.6" "1349.5" "1357.4" "1324.7" "1237.7" "1376.1" "3004.9" "" "" "" "" "" "" "" "" "" "" "1239.0" "1078.7" "1244.5" "1324.3" "1113.6" "1357.4" "991.9" "1093.2" "1231.3" "1072.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4758086446517534587" "False" "High" "IsMasterProtein" "P62316" "Small nuclear ribonucleoprotein Sm D2 OS=Homo sapiens OX=9606 GN=SNRPD2 PE=1 SV=1" "0.000" "False" "58.719" "62" "8" "35" "8" "118" "13.5" "9.91" "127.97" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6633" "ENSG00000125743" "SNRPD2" "A8K797; hsa:6633; J3KPM5; P43330; P62316" "mRNA processing" "mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; snRNP Assembly; mRNA Splicing - Minor Pathway" "5" "0" "0.978" "1.006" "0.961" "0.998" "1.056" "0.959" "0.995" "0.969" "0.829" "3855.3" "3772.1" "3877.0" "3703.9" "3846.4" "4071.7" "3696.9" "3835.5" "3736.0" "3194.7" "" "" "" "" "" "" "" "" "" "" "3466.3" "3052.3" "3506.9" "3615.5" "3174.1" "4071.7" "2768.1" "3387.8" "3342.9" "1140.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179011071974481602" "False" "High" "IsMasterProtein" "Q9NWS0" "PIH1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PIH1D1 PE=1 SV=1" "0.000" "False" "58.699" "53" "11" "19" "11" "290" "32.3" "5.14" "74.41" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08190, Pf18201" "55011" "ENSG00000104872" "PIH1D1" "B4DGN7; B4E2X7; hsa:55011; Q9BVL0; Q9NWS0" "" "" "0" "0" "0.978" "0.941" "1.036" "0.976" "1.049" "0.983" "1.006" "0.983" "1.176" "1204.0" "1177.2" "1133.4" "1247.2" "1175.5" "1263.4" "1183.1" "1211.6" "1183.4" "1416.4" "" "" "" "" "" "" "" "" "" "" "1082.6" "952.5" "1025.2" "1217.4" "970.1" "1263.4" "885.9" "1070.2" "1058.9" "505.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972522835468462088" "False" "High" "IsMasterProtein" "O43432" "Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens OX=9606 GN=EIF4G3 PE=1 SV=2" "0.000" "False" "58.673" "8" "13" "29" "5" "1585" "176.5" "5.38" "88.48" "13" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf02020, Pf02847, Pf02854" "8672" "ENSG00000075151" "EIF4G3" "B9EGQ7; hsa:8672; O43432; Q15597; Q504Z1; Q5SWC3; Q8NEN1" "Translation factors; Translation inhibitors in chronically activated PDGFRA cells" "ISG15 antiviral mechanism" "3" "0" "0.947" "0.962" "1.017" "0.984" "1.038" "1.108" "0.960" "0.982" "3.922" "239.9" "227.1" "230.8" "244.0" "236.1" "248.9" "265.7" "230.2" "235.5" "940.8" "" "" "" "" "" "" "" "" "" "" "215.7" "183.7" "208.8" "238.2" "194.9" "248.9" "199.0" "203.3" "210.7" "335.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079074271338885879" "False" "High" "IsMasterProtein" "P16403" "Histone H1.2 OS=Homo sapiens OX=9606 GN=H1-2 PE=1 SV=2" "0.000" "False" "58.575" "41" "13" "30" "4" "213" "21.4" "10.93" "111.95" "13" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3006" "ENSG00000187837" "H1-2" "A8K4I2; hsa:3006; P16403" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "9" "1.000" "0.896" "1.013" "0.909" "0.910" "0.965" "0.972" "0.780" "0.704" "4387.2" "4386.5" "3931.0" "4442.7" "3987.3" "3993.3" "4234.9" "4265.5" "3423.7" "3086.4" "" "" "" "" "" "" "" "" "" "" "3944.5" "3549.4" "3555.7" "4336.6" "3290.4" "3993.3" "3171.0" "3767.5" "3063.5" "1101.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3377056009907556172" "False" "High" "IsMasterProtein" "O14745" "Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Homo sapiens OX=9606 GN=NHERF1 PE=1 SV=4" "0.000" "False" "58.413" "35" "11" "19" "11" "358" "38.8" "5.77" "78.14" "11" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf00595, Pf09007" "9368" "ENSG00000109062" "NHERF1" "B3KY21; hsa:9368; O14745; O43552; Q86WQ5" "TAR syndrome" "" "1" "0" "0.874" "0.959" "0.961" "1.008" "1.000" "0.964" "1.000" "0.987" "0.775" "2073.9" "1813.6" "1988.6" "1993.6" "2091.4" "2074.0" "1998.7" "2073.0" "2046.9" "1607.8" "" "" "" "" "" "" "" "" "" "" "1864.6" "1467.5" "1798.8" "1946.0" "1725.8" "2074.0" "1496.6" "1831.0" "1831.6" "573.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7031354914438909062" "False" "High" "IsMasterProtein" "O60282" "Kinesin heavy chain isoform 5C OS=Homo sapiens OX=9606 GN=KIF5C PE=1 SV=1" "0.000" "False" "58.407" "15" "14" "27" "1" "957" "109.4" "6.19" "93.77" "14" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00225" "3800" "ENSG00000168280" "KIF5C" "hsa:3800; O60282; O95079; Q2YDC5" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Insulin processing" "3" "1" "0.978" "1.004" "0.993" "1.005" "0.954" "1.051" "1.025" "1.022" "1.131" "348.5" "340.7" "349.9" "346.0" "350.2" "332.4" "366.2" "357.1" "356.1" "394.2" "" "" "" "" "" "" "" "" "" "" "313.4" "275.7" "316.5" "337.8" "289.0" "332.4" "274.2" "315.4" "318.7" "140.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9034564449228548140" "False" "High" "IsMasterProtein" "O75223" "Gamma-glutamylcyclotransferase OS=Homo sapiens OX=9606 GN=GGCT PE=1 SV=1" "0.000" "False" "58.399" "58" "9" "25" "9" "188" "21.0" "5.14" "91.72" "9" "cell organization and biogenesis;signal transduction" "cytosol" "other molecular function" "Pf13772" "79017" "ENSG00000006625" "GGCT" "B2RDN0; B8ZZN4; B8ZZR8; hsa:79017; O75223; Q9BS37" "" "Glutathione synthesis and recycling" "1" "0" "1.057" "1.055" "1.135" "1.086" "1.040" "1.001" "1.032" "1.077" "0.809" "3411.5" "3607.3" "3597.6" "3870.8" "3704.5" "3549.3" "3416.4" "3521.7" "3675.1" "2761.5" "" "" "" "" "" "" "" "" "" "" "3067.3" "2918.9" "3254.2" "3778.5" "3057.0" "3549.3" "2558.1" "3110.6" "3288.5" "985.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4687575668731336676" "False" "High" "IsMasterProtein" "Q6UX04" "Spliceosome-associated protein CWC27 homolog OS=Homo sapiens OX=9606 GN=CWC27 PE=1 SV=1" "0.000" "False" "58.397" "36" "13" "20" "13" "472" "53.8" "5.80" "78.19" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00160" "10283" "ENSG00000153015" "CWC27" "hsa:10283; O60529; O60530; Q6UX04; Q96EM3" "" "mRNA Splicing - Major Pathway" "1" "0" "1.026" "1.040" "0.984" "1.064" "0.959" "1.038" "1.062" "1.078" "1.052" "1136.3" "1165.6" "1181.6" "1117.8" "1209.5" "1089.2" "1179.5" "1206.4" "1224.4" "1195.6" "" "" "" "" "" "" "" "" "" "" "1021.6" "943.2" "1068.8" "1091.1" "998.1" "1089.2" "883.2" "1065.6" "1095.6" "426.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8027894993262294813" "False" "High" "IsMasterProtein" "Q13131" "5'-AMP-activated protein kinase catalytic subunit alpha-1 OS=Homo sapiens OX=9606 GN=PRKAA1 PE=1 SV=4" "0.000" "False" "58.367" "33" "15" "23" "15" "559" "64.0" "8.12" "85.09" "15" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf16579, Pf21147" "5562" "ENSG00000132356" "PRKAA1" "A8MTQ6; B2R7E1; hsa:5562; O00286; Q13131; Q5D0E1; Q86VS1; Q9UNQ4" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Thyroxine (thyroid hormone) production; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; mir-124 predicted interactions with cell cycle and differentiation ; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Insulin signaling; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Pleural mesothelioma; Affected pathways in Duchenne muscular dystrophy; ADHD and autism (ASD) linked metabolic pathways and SNP" "Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "36" "0" "1.039" "1.024" "1.020" "1.027" "0.986" "1.006" "0.977" "1.089" "0.936" "1833.8" "1904.5" "1878.8" "1869.7" "1883.5" "1807.8" "1844.6" "1790.9" "1996.8" "1717.0" "" "" "" "" "" "" "" "" "" "" "1648.8" "1541.0" "1699.4" "1825.1" "1554.3" "1807.8" "1381.2" "1581.8" "1786.7" "612.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570551838394526128" "False" "High" "IsMasterProtein" "Q86VN1" "Vacuolar protein-sorting-associated protein 36 OS=Homo sapiens OX=9606 GN=VPS36 PE=1 SV=1" "0.000" "False" "58.335" "38" "12" "17" "12" "386" "43.8" "7.20" "68.83" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf04157, Pf11605" "51028" "ENSG00000136100" "VPS36" "A8K125; hsa:51028; Q3ZCV7; Q5H9S1; Q5VXB6; Q86VN1; Q9H8Z5; Q9Y3E3" "Network map of SARS-CoV-2 signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "3" "0" "1.043" "0.903" "0.908" "1.060" "1.030" "1.022" "0.968" "1.010" "0.805" "1060.8" "1106.3" "958.4" "963.2" "1124.4" "1092.3" "1084.2" "1026.6" "1071.9" "853.6" "" "" "" "" "" "" "" "" "" "" "953.8" "895.2" "866.9" "940.2" "927.9" "1092.3" "811.8" "906.7" "959.1" "304.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6548869844035824343" "False" "High" "IsMasterProtein" "Q9UKM9" "RNA-binding protein Raly OS=Homo sapiens OX=9606 GN=RALY PE=1 SV=1" "0.000" "False" "58.249" "45" "14" "26" "14" "306" "32.4" "9.17" "86.54" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "22913" "ENSG00000125970" "RALY" "hsa:22913; Q14621; Q2M365; Q5QPL8; Q9BQX6; Q9UJE3; Q9UKM9" "" "" "0" "0" "0.989" "0.883" "0.978" "0.978" "0.899" "0.988" "0.941" "0.865" "1.702" "2886.9" "2855.9" "2549.1" "2822.3" "2823.7" "2594.6" "2852.1" "2716.9" "2496.9" "4912.9" "" "" "" "" "" "" "" "" "" "" "2595.6" "2310.9" "2305.7" "2755.0" "2330.1" "2594.6" "2135.6" "2399.8" "2234.2" "1753.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9165342661713370894" "False" "High" "IsMasterProtein" "Q969U7" "Proteasome assembly chaperone 2 OS=Homo sapiens OX=9606 GN=PSMG2 PE=1 SV=1" "0.000" "False" "58.222" "33" "9" "32" "9" "264" "29.4" "6.98" "96.97" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf09754" "56984" "ENSG00000128789" "PSMG2" "B0YJB3; hsa:56984; Q6IAH4; Q969U7; Q9NRV1; V9GYH7" "" "" "0" "0" "1.025" "1.003" "0.972" "1.029" "0.964" "1.005" "0.997" "1.018" "0.792" "2955.4" "3029.7" "2965.3" "2873.0" "3040.6" "2847.8" "2969.4" "2947.9" "3008.7" "2341.1" "" "" "" "" "" "" "" "" "" "" "2657.2" "2451.5" "2682.2" "2804.5" "2509.2" "2847.8" "2223.4" "2603.8" "2692.2" "835.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848628119440074227" "False" "High" "IsMasterProtein" "P30038" "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH4A1 PE=1 SV=3" "0.000" "False" "58.194" "27" "14" "21" "14" "563" "61.7" "8.07" "73.77" "14" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00171" "8659" "ENSG00000159423" "ALDH4A1" "A8K1Q7; B4DGE4; D2D4A3; hsa:8659; P30038; Q16882; Q53HU4; Q5JNV6; Q8IZ38; Q96IF0; Q9UDI6" "22q11.2 copy number variation syndrome; p53 transcriptional gene network" "Glyoxylate metabolism and glycine degradation; Proline catabolism" "4" "0" "1.090" "1.060" "0.997" "1.127" "1.117" "1.113" "1.150" "1.166" "0.969" "1458.3" "1589.4" "1545.5" "1454.3" "1643.8" "1628.8" "1623.5" "1676.7" "1700.0" "1412.6" "" "" "" "" "" "" "" "" "" "" "1311.2" "1286.1" "1397.9" "1419.6" "1356.5" "1628.8" "1215.7" "1481.0" "1521.2" "504.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6270565792586481652" "False" "High" "IsMasterProtein" "Q9UHY7" "Enolase-phosphatase E1 OS=Homo sapiens OX=9606 GN=ENOPH1 PE=1 SV=1" "0.000" "False" "58.183" "55" "10" "23" "10" "261" "28.9" "4.78" "102.61" "10" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00702" "58478" "ENSG00000145293" "ENOPH1" "hsa:58478; Q7Z4C5; Q9BVC2; Q9UHY7" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "1.028" "1.060" "1.017" "0.982" "1.001" "1.116" "0.973" "1.010" "1.118" "1289.9" "1325.6" "1367.2" "1312.0" "1266.6" "1291.2" "1439.6" "1254.6" "1302.7" "1442.3" "" "" "" "" "" "" "" "" "" "" "1159.8" "1072.6" "1236.7" "1280.7" "1045.2" "1291.2" "1078.0" "1108.2" "1165.6" "514.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "410623999248744867" "False" "High" "IsMasterProtein" "Q6PKG0" "La-related protein 1 OS=Homo sapiens OX=9606 GN=LARP1 PE=1 SV=2" "0.000" "False" "58.118" "18" "18" "25" "18" "1096" "123.4" "8.82" "76.07" "18" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf05383, Pf21071" "23367" "ENSG00000155506" "LARP1" "hsa:23367; O94836; Q6PKG0; Q8N4M2; Q8NB73; Q9UFD7" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "4" "0" "1.010" "0.982" "0.940" "1.062" "0.998" "1.002" "0.946" "0.904" "0.948" "1714.4" "1730.7" "1683.7" "1612.2" "1821.5" "1710.6" "1718.3" "1621.6" "1550.2" "1625.3" "" "" "" "" "" "" "" "" "" "" "1541.4" "1400.5" "1522.9" "1573.8" "1503.1" "1710.6" "1286.6" "1432.3" "1387.1" "580.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "185652229165611282" "False" "High" "IsMasterProtein" "Q9NY27" "Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP4R2 PE=1 SV=3" "0.000" "False" "58.002" "41" "11" "16" "11" "417" "46.9" "4.54" "68.07" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09184" "151987" "ENSG00000163605" "PPP4R2" "A8K1I6; hsa:151987; Q2TAJ9; Q498B8; Q8WXX6; Q9NY27" "16p11.2 proximal deletion syndrome" "Processing of DNA double-strand break ends" "2" "0" "1.024" "1.042" "0.946" "1.040" "1.000" "0.991" "1.046" "1.042" "0.935" "1169.6" "1197.4" "1219.1" "1106.9" "1216.8" "1169.1" "1158.7" "1224.0" "1218.4" "1093.2" "" "" "" "" "" "" "" "" "" "" "1051.6" "968.9" "1102.7" "1080.5" "1004.1" "1169.1" "867.6" "1081.1" "1090.2" "390.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5015398897820644174" "False" "High" "IsMasterProtein" "O14757" "Serine/threonine-protein kinase Chk1 OS=Homo sapiens OX=9606 GN=CHEK1 PE=1 SV=2" "0.000" "False" "57.942" "32" "14" "22" "14" "476" "54.4" "8.25" "77.09" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1111" "ENSG00000149554" "CHEK1" "A8K934; B4DDD0; B4DSK3; B5BTY6; F5H7S4; H2BI51; hsa:1111; O14757" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATR signaling; ATM signaling in development and disease ; DNA repair pathways, full network; TROP2 regulatory signaling; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Transcriptional Regulation by E2F6; Signaling by SCF-KIT; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex" "18" "0" "0.798" "0.802" "0.979" "0.808" "0.800" "1.006" "0.804" "0.840" "0.865" "2454.6" "1958.3" "1968.7" "2402.0" "1984.4" "1964.6" "2470.4" "1974.5" "2062.3" "2122.5" "" "" "" "" "" "" "" "" "" "" "2207.0" "1584.6" "1780.7" "2344.6" "1637.6" "1964.6" "1849.8" "1744.0" "1845.3" "757.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3614438977501336635" "False" "High" "IsMasterProtein" "Q92558" "Actin-binding protein WASF1 OS=Homo sapiens OX=9606 GN=WASF1 PE=1 SV=1" "0.000" "False" "57.869" "24" "11" "19" "11" "559" "61.6" "6.46" "84.20" "11" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf02205" "8936" "ENSG00000112290" "WASF1" "E1P5F2; hsa:8936; Q5SZK7; Q92558" "VEGFA-VEGFR2 signaling; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; RAC1 GTPase cycle; RAC3 GTPase cycle; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "8" "0" "1.037" "1.004" "0.974" "1.057" "0.984" "1.047" "1.053" "0.984" "0.815" "1806.8" "1874.1" "1813.9" "1759.1" "1910.2" "1777.9" "1892.2" "1903.1" "1778.6" "1472.4" "" "" "" "" "" "" "" "" "" "" "1624.5" "1516.5" "1640.8" "1717.1" "1576.4" "1777.9" "1416.8" "1680.9" "1591.4" "525.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262378899326464303" "False" "High" "IsMasterProtein" "Q9BRX5" "DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1" "0.000" "False" "57.838" "67" "12" "22" "12" "216" "24.5" "5.34" "86.19" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "nucleus" "" "Pf05916" "64785" "ENSG00000181938" "GINS3" "B2RDP3; E9PB21; hsa:64785; Q9BRX5; Q9H870" "" "Unwinding of DNA" "1" "0" "0.953" "0.978" "0.930" "0.952" "0.978" "0.972" "0.969" "0.972" "0.952" "2040.3" "1944.6" "1994.5" "1898.1" "1943.3" "1995.6" "1982.2" "1977.1" "1983.7" "1942.2" "" "" "" "" "" "" "" "" "" "" "1834.5" "1573.5" "1804.1" "1852.8" "1603.6" "1995.6" "1484.2" "1746.3" "1775.0" "693.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5706954355209209913" "False" "High" "IsMasterProtein" "Q99436" "Proteasome subunit beta type-7 OS=Homo sapiens OX=9606 GN=PSMB7 PE=1 SV=1" "0.000" "False" "57.830" "44" "9" "26" "9" "277" "29.9" "7.68" "102.59" "9" "protein metabolism;other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5695" "ENSG00000136930" "PSMB7" "B4E0P1; hsa:5695; Q5TBG6; Q96AG8; Q99436; Q9BWA7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Neutrophil degranulation; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "63" "0" "0.978" "0.943" "0.985" "0.952" "0.855" "0.962" "0.954" "0.945" "0.773" "4458.3" "4361.6" "4203.3" "4389.4" "4244.4" "3811.6" "4288.1" "4255.1" "4212.0" "3444.7" "" "" "" "" "" "" "" "" "" "" "4008.5" "3529.2" "3802.1" "4284.7" "3502.6" "3811.6" "3210.8" "3758.4" "3768.9" "1229.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4101448346661809879" "False" "High" "IsMasterProtein" "Q15819" "Ubiquitin-conjugating enzyme E2 variant 2 OS=Homo sapiens OX=9606 GN=UBE2V2 PE=1 SV=4" "0.000" "False" "57.751" "58" "8" "48" "3" "145" "16.4" "8.09" "160.65" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00179" "7336" "ENSG00000169139" "UBE2V2" "hsa:7336; Q15819" "" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; Formation of Incision Complex in GG-NER; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "7" "0" "0.972" "1.028" "1.024" "1.083" "0.988" "1.060" "1.050" "1.030" "0.808" "945.2" "918.5" "972.0" "967.6" "1023.5" "934.1" "1001.9" "992.6" "973.4" "764.0" "" "" "" "" "" "" "" "" "" "" "849.9" "743.2" "879.2" "944.5" "844.6" "934.1" "750.2" "876.8" "871.0" "272.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8252267867784187079" "False" "High" "IsMasterProtein" "Q86YP4" "Transcriptional repressor p66-alpha OS=Homo sapiens OX=9606 GN=GATAD2A PE=1 SV=1" "0.000" "False" "57.728" "23" "13" "18" "12" "633" "68.0" "9.94" "63.05" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "54815" "ENSG00000167491" "GATAD2A" "B5MC40; hsa:54815; Q7L3J2; Q86YP4; Q96F28; Q9NPU2; Q9NXS1" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "1" "0.957" "0.974" "0.923" "1.003" "1.041" "0.996" "0.914" "0.952" "1.867" "1282.9" "1227.9" "1249.2" "1183.9" "1286.3" "1335.7" "1278.0" "1172.1" "1221.2" "2394.9" "" "" "" "" "" "" "" "" "" "" "1153.5" "993.6" "1130.0" "1155.7" "1061.5" "1335.7" "956.9" "1035.2" "1092.8" "854.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9162404171034655345" "False" "High" "IsMasterProtein" "Q9Y223" "Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase OS=Homo sapiens OX=9606 GN=GNE PE=1 SV=1" "0.000" "False" "57.722" "21" "14" "18" "14" "722" "79.2" "6.80" "65.65" "14" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00480, Pf02350" "10020" "ENSG00000159921" "GNE" "A6PZH2; A6PZH3; A7UNU7; B2R6E1; B7Z372; B7Z428; D3DRP7; F5H499; H0YFA7; hsa:10020; Q0VA94; Q9Y223" "Sialylation" "Sialic acid metabolism; Defective GNE causes sialuria, NK and IBM2" "3" "0" "1.014" "1.034" "0.989" "1.045" "1.000" "1.058" "1.013" "1.045" "0.840" "1290.6" "1309.3" "1334.1" "1276.4" "1348.8" "1290.0" "1365.8" "1307.6" "1349.2" "1083.6" "" "" "" "" "" "" "" "" "" "" "1160.4" "1059.4" "1206.8" "1245.9" "1113.1" "1290.0" "1022.7" "1155.0" "1207.3" "386.8" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227008394942671266" "False" "High" "IsMasterProtein" "Q9BUQ8" "Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens OX=9606 GN=DDX23 PE=1 SV=3" "0.000" "False" "57.672" "19" "15" "20" "15" "820" "95.5" "9.55" "75.89" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "9416" "ENSG00000174243" "DDX23" "B2R600; B4DH15; hsa:9416; O43188; Q9BUQ8" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "0.950" "0.952" "0.872" "0.959" "1.029" "0.922" "0.901" "0.889" "0.528" "967.5" "919.0" "920.8" "843.4" "927.9" "995.9" "892.1" "871.4" "860.1" "510.9" "" "" "" "" "" "" "" "" "" "" "869.9" "743.6" "832.8" "823.3" "765.8" "995.9" "668.0" "769.7" "769.6" "182.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5564362200897381814" "False" "High" "IsMasterProtein" "Q9P2N5" "RNA-binding protein 27 OS=Homo sapiens OX=9606 GN=RBM27 PE=1 SV=2" "0.000" "False" "57.652" "15" "15" "17" "15" "1060" "118.6" "9.19" "67.96" "15" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00076, Pf00642, Pf01480" "54439" "ENSG00000091009" "RBM27" "hsa:54439; Q8IYW9; Q9P2N5" "" "" "0" "0" "0.993" "0.977" "0.975" "1.055" "1.040" "1.105" "0.974" "0.963" "1.092" "1031.5" "1024.4" "1008.1" "1005.8" "1088.1" "1072.7" "1139.6" "1005.0" "992.8" "1126.7" "" "" "" "" "" "" "" "" "" "" "927.4" "828.9" "911.8" "981.8" "897.9" "1072.7" "853.3" "887.7" "888.4" "402.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4027474892696141167" "False" "High" "IsMasterProtein" "Q9BZI7" "Regulator of nonsense transcripts 3B OS=Homo sapiens OX=9606 GN=UPF3B PE=1 SV=1" "0.000" "False" "57.596" "33" "15" "25" "15" "483" "57.7" "9.48" "89.50" "15" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65109" "ENSG00000125351" "UPF3B" "D3DWI3; D3DWI4; hsa:65109; Q0VAK8; Q9BZI7; Q9H1J0" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing" "6" "0" "0.933" "1.027" "0.966" "0.979" "1.043" "0.975" "1.006" "1.033" "1.078" "2371.7" "2212.1" "2436.6" "2292.2" "2321.1" "2472.7" "2312.5" "2385.5" "2450.2" "2556.8" "" "" "" "" "" "" "" "" "" "" "2132.4" "1790.0" "2204.0" "2237.5" "1915.4" "2472.7" "1731.5" "2107.1" "2192.5" "912.7" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272350597619465793" "False" "High" "IsMasterProtein" "O00743" "Serine/threonine-protein phosphatase 6 catalytic subunit OS=Homo sapiens OX=9606 GN=PPP6C PE=1 SV=1" "0.000" "False" "57.585" "47" "12" "24" "12" "305" "35.1" "5.69" "79.49" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00149" "5537" "ENSG00000119414" "PPP6C" "B2R5V6; B7Z2W9; B7Z5K9; hsa:5537; O00743; Q5U0A2; Q9UIC9" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.026" "1.050" "1.054" "1.020" "0.976" "0.950" "0.932" "1.040" "0.897" "1823.6" "1870.6" "1914.1" "1922.4" "1860.3" "1779.5" "1731.8" "1699.5" "1895.8" "1635.3" "" "" "" "" "" "" "" "" "" "" "1639.6" "1513.6" "1731.4" "1876.6" "1535.1" "1779.5" "1296.7" "1501.1" "1696.4" "583.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "714954485545523239" "False" "High" "IsMasterProtein" "P27986" "Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Homo sapiens OX=9606 GN=PIK3R1 PE=1 SV=2" "0.000" "False" "57.574" "23" "17" "22" "13" "724" "83.5" "6.16" "71.96" "17" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5295" "ENSG00000145675" "PIK3R1" "B3KT19; D3DWA0; E7EX19; hsa:5295; P27986; Q15747; Q4VBZ7; Q53EM6; Q8IXA2; Q8N1C5" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 4p16.3 copy number variation; 5q35 copy number variation; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "G alpha (q) signalling events; Extra-nuclear estrogen signaling; RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RHOC GTPase cycle; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle; Interleukin-4 and Interleukin-13 signaling; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; GP1b-IX-V activation signalling; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "154" "2" "1.033" "1.000" "1.022" "1.035" "0.977" "1.125" "1.011" "1.011" "1.025" "2244.1" "2317.6" "2245.1" "2294.4" "2321.9" "2191.6" "2524.7" "2267.8" "2269.8" "2299.8" "" "" "" "" "" "" "" "" "" "" "2017.6" "1875.3" "2030.8" "2239.7" "1916.1" "2191.6" "1890.4" "2003.0" "2031.0" "821.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3851715051474233643" "False" "High" "IsMasterProtein" "Q9P2A4" "ABI gene family member 3 OS=Homo sapiens OX=9606 GN=ABI3 PE=1 SV=2" "0.000" "False" "57.510" "36" "11" "16" "11" "366" "39.0" "5.08" "68.83" "11" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "cytoskeletal activity;other molecular function" "Pf07815, Pf14604" "51225" "ENSG00000108798" "ABI3" "C9IZN8; hsa:51225; Q9H0P6; Q9P2A4" "" "" "0" "0" "0.960" "0.993" "1.094" "0.923" "1.041" "0.983" "1.058" "1.082" "0.806" "1266.9" "1216.5" "1258.2" "1385.8" "1169.1" "1319.4" "1245.4" "1340.5" "1370.9" "1020.9" "" "" "" "" "" "" "" "" "" "" "1139.0" "984.4" "1138.1" "1352.7" "964.8" "1319.4" "932.6" "1184.0" "1226.7" "364.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4733081690105890722" "False" "High" "IsMasterProtein" "Q9UKN8" "General transcription factor 3C polypeptide 4 OS=Homo sapiens OX=9606 GN=GTF3C4 PE=1 SV=2" "0.000" "False" "57.510" "26" "17" "18" "17" "822" "91.9" "6.65" "65.16" "17" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf12657, Pf12660, Pf19336" "9329" "ENSG00000125484" "GTF3C4" "hsa:9329; Q5VZJ7; Q9UKN8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "1.054" "1.147" "0.930" "1.113" "1.000" "1.039" "1.026" "1.059" "0.867" "1197.5" "1261.9" "1373.9" "1113.7" "1332.7" "1198.1" "1243.9" "1228.7" "1268.5" "1037.8" "" "" "" "" "" "" "" "" "" "" "1076.7" "1021.0" "1242.7" "1087.1" "1099.8" "1198.1" "931.4" "1085.3" "1135.0" "370.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9179155935409940173" "False" "High" "IsMasterProtein" "Q15750" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens OX=9606 GN=TAB1 PE=1 SV=1" "0.000" "False" "57.504" "25" "10" "14" "10" "504" "54.6" "5.52" "66.58" "10" "developmental processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "10454" "ENSG00000100324" "TAB1" "hsa:10454; Q15750; Q2PP09; Q8IZW2" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; TGF-beta signaling pathway; MAPK signaling pathway; TLR4 signaling and tolerance; miRNA role in immune response in sepsis; Signal transduction through IL1R; Hepatitis B infection; Toll-like receptor signaling pathway" "NOD1/2 Signaling Pathway; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "1.073" "1.032" "1.001" "1.038" "1.014" "1.068" "0.986" "1.049" "1.071" "1484.8" "1592.5" "1532.5" "1486.5" "1540.8" "1506.3" "1586.5" "1464.7" "1558.0" "1590.6" "" "" "" "" "" "" "" "" "" "" "1335.0" "1288.6" "1386.2" "1451.0" "1271.5" "1506.3" "1187.9" "1293.7" "1394.1" "567.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5897019344324903703" "False" "High" "IsMasterProtein" "Q9NP79" "Vacuolar protein sorting-associated protein VTA1 homolog OS=Homo sapiens OX=9606 GN=VTA1 PE=1 SV=1" "0.000" "False" "57.444" "32" "9" "24" "9" "307" "33.9" "6.29" "94.54" "9" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04652, Pf18097" "51534" "ENSG00000009844" "VTA1" "B4DW55; E1P594; E7ETQ7; hsa:51534; Q5TGM1; Q6IAE8; Q9H0R2; Q9H3K9; Q9NP79; Q9P0Q0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "2" "0" "0.980" "0.997" "1.023" "1.020" "0.976" "1.028" "1.007" "1.022" "0.935" "2589.2" "2537.7" "2581.9" "2648.9" "2640.9" "2526.9" "2661.6" "2606.3" "2645.1" "2420.3" "" "" "" "" "" "" "" "" "" "" "2327.9" "2053.4" "2335.4" "2585.7" "2179.3" "2526.9" "1992.9" "2302.1" "2366.8" "864.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874142018275296018" "False" "High" "IsMasterProtein" "A6NHR9" "Structural maintenance of chromosomes flexible hinge domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SMCHD1 PE=1 SV=2" "0.000" "False" "57.433" "11" "17" "18" "17" "2005" "226.2" "7.30" "68.43" "17" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06470, Pf13589" "23347" "ENSG00000101596" "SMCHD1" "A6NHR9; O75141; Q6AHX6; Q6ZTQ8; Q9H6Q2; Q9UG39" "" "" "0" "0" "1.022" "1.008" "1.022" "1.077" "1.015" "1.053" "0.874" "0.927" "5.529" "1015.9" "1038.8" "1023.7" "1038.7" "1093.8" "1031.5" "1069.9" "887.9" "941.4" "5617.3" "" "" "" "" "" "" "" "" "" "" "913.4" "840.6" "925.9" "1013.9" "902.7" "1031.5" "801.1" "784.2" "842.3" "2005.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9134021061211319467" "False" "High" "IsMasterProtein" "Q9HA77" "Probable cysteine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=CARS2 PE=1 SV=1" "0.000" "False" "57.433" "25" "13" "20" "13" "564" "62.2" "8.34" "81.08" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01406" "79587" "ENSG00000134905" "CARS2" "hsa:79587; Q8NI84; Q96IV4; Q9HA77" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.024" "0.977" "0.988" "1.083" "1.043" "1.060" "1.057" "1.023" "0.785" "1707.8" "1748.8" "1667.7" "1686.8" "1849.8" "1780.5" "1810.0" "1805.1" "1747.7" "1340.0" "" "" "" "" "" "" "" "" "" "" "1535.5" "1415.1" "1508.5" "1646.5" "1526.5" "1780.5" "1355.3" "1594.4" "1563.9" "478.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4208729749156870383" "False" "High" "IsMasterProtein" "O60678" "Protein arginine N-methyltransferase 3 OS=Homo sapiens OX=9606 GN=PRMT3 PE=1 SV=4" "0.000" "False" "57.401" "30" "13" "17" "13" "531" "59.9" "5.35" "65.96" "13" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf06325, Pf21137, Pf21336" "10196" "ENSG00000185238" "PRMT3" "A0A0A0MSN7; B4DUC7; hsa:10196; O60678" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines; Protein methylation" "3" "0" "1.040" "0.998" "1.008" "1.013" "0.972" "0.995" "0.955" "1.004" "0.864" "1412.4" "1468.5" "1408.9" "1423.2" "1430.6" "1373.3" "1406.0" "1349.5" "1417.4" "1219.7" "" "" "" "" "" "" "" "" "" "" "1269.9" "1188.2" "1274.4" "1389.3" "1180.5" "1373.3" "1052.8" "1191.9" "1268.3" "435.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1681644365065118187" "False" "High" "IsMasterProtein" "Q8IVS2" "Malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Homo sapiens OX=9606 GN=MCAT PE=1 SV=2" "0.000" "False" "57.327" "47" "13" "16" "13" "390" "42.9" "8.72" "68.07" "13" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00698" "27349" "ENSG00000100294" "MCAT" "B0QY72; O95510; O95511; Q8IVS2" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial Fatty Acid Beta-Oxidation" "2" "0" "1.095" "1.050" "1.008" "1.065" "1.045" "1.043" "1.046" "0.993" "0.805" "1295.7" "1419.2" "1360.8" "1306.7" "1379.5" "1354.6" "1350.9" "1355.8" "1287.3" "1043.0" "" "" "" "" "" "" "" "" "" "" "1165.0" "1148.4" "1230.9" "1275.5" "1138.4" "1354.6" "1011.5" "1197.5" "1151.8" "372.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "412989267492622894" "False" "High" "IsMasterProtein" "Q12874" "Splicing factor 3A subunit 3 OS=Homo sapiens OX=9606 GN=SF3A3 PE=1 SV=1" "0.000" "False" "57.286" "33" "13" "19" "13" "501" "58.8" "5.38" "77.33" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf11931, Pf12108, Pf13297, Pf16837" "10946" "ENSG00000183431" "SF3A3" "D3DPT5; hsa:10946; Q12874; Q15460; Q5VT87" "Exercise-induced circadian regulation; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "0.909" "0.919" "0.993" "0.913" "0.868" "0.970" "0.888" "0.841" "2.137" "2598.8" "2361.8" "2387.5" "2580.1" "2373.2" "2257.0" "2521.1" "2307.2" "2184.4" "5554.7" "" "" "" "" "" "" "" "" "" "" "2336.6" "1911.1" "2159.6" "2518.5" "1958.4" "2257.0" "1887.7" "2037.9" "1954.5" "1982.9" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-765021547925747573" "False" "High" "IsMasterProtein" "P49366" "Deoxyhypusine synthase OS=Homo sapiens OX=9606 GN=DHPS PE=1 SV=1" "0.000" "False" "57.272" "33" "11" "20" "11" "369" "40.9" "5.36" "68.17" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01916" "1725" "ENSG00000095059" "DHPS" "A8K688; hsa:1725; M0R1I5; P49366; Q13184; Q13276; Q9UDG0" "" "Hypusine synthesis from eIF5A-lysine" "1" "0" "1.068" "1.072" "1.102" "1.151" "1.068" "1.138" "1.111" "1.105" "0.845" "1163.4" "1242.6" "1247.4" "1282.0" "1338.6" "1242.8" "1324.3" "1292.8" "1285.0" "983.3" "" "" "" "" "" "" "" "" "" "" "1046.0" "1005.4" "1128.3" "1251.4" "1104.6" "1242.8" "991.6" "1141.9" "1149.8" "351.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9188891296985920952" "False" "High" "IsMasterProtein" "P31483" "Cytotoxic granule associated RNA binding protein TIA1 OS=Homo sapiens OX=9606 GN=TIA1 PE=1 SV=3" "0.000" "False" "57.233" "34" "12" "26" "8" "386" "42.9" "7.74" "101.75" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "7072" "ENSG00000116001" "TIA1" "hsa:7072; P31483; Q53SS9; Q96B58" "" "FGFR2 alternative splicing" "1" "3" "1.044" "0.977" "1.083" "1.048" "1.038" "1.059" "1.069" "1.067" "0.859" "1434.1" "1497.2" "1400.7" "1552.7" "1502.5" "1488.2" "1519.1" "1533.4" "1530.1" "1231.7" "" "" "" "" "" "" "" "" "" "" "1289.4" "1211.5" "1267.0" "1515.7" "1239.9" "1488.2" "1137.5" "1354.4" "1369.1" "439.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5912307548831863099" "False" "High" "IsMasterProtein" "P25398" "Small ribosomal subunit protein eS12 OS=Homo sapiens OX=9606 GN=RPS12 PE=1 SV=3" "0.000" "False" "57.202" "54" "7" "24" "7" "132" "14.5" "7.21" "100.63" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6206" "ENSG00000112306" "RPS12" "hsa:6206; P25398; Q76M58" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.911" "0.912" "0.946" "1.023" "0.965" "0.980" "1.100" "0.953" "0.788" "3686.9" "3357.1" "3363.3" "3486.9" "3771.8" "3558.6" "3613.1" "4056.9" "3511.8" "2907.0" "" "" "" "" "" "" "" "" "" "" "3314.9" "2716.5" "3042.2" "3403.7" "3112.5" "3558.6" "2705.4" "3583.3" "3142.4" "1037.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4417786093828078874" "False" "High" "IsMasterProtein" "Q9H1A4" "Anaphase-promoting complex subunit 1 OS=Homo sapiens OX=9606 GN=ANAPC1 PE=1 SV=1" "0.000" "False" "57.200" "10" "20" "24" "20" "1944" "216.4" "6.30" "76.52" "20" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12859, Pf18122, Pf20518, Pf21282" "64682" "ENSG00000153107" "ANAPC1" "hsa:64682; Q2M3H8; Q9BSE6; Q9H1A4; Q9H8D0" "Cell cycle; 2q13 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Senescence-Associated Secretory Phenotype (SASP); APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "0.999" "1.014" "0.952" "0.963" "0.955" "0.953" "0.965" "1.038" "0.966" "1965.4" "1963.7" "1993.6" "1870.5" "1892.9" "1876.9" "1872.2" "1896.4" "2039.9" "1899.4" "" "" "" "" "" "" "" "" "" "" "1767.1" "1588.9" "1803.3" "1825.9" "1562.1" "1876.9" "1401.9" "1675.1" "1825.3" "678.0" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9144980634344963458" "False" "High" "IsMasterProtein" "O14686" "Histone-lysine N-methyltransferase 2D OS=Homo sapiens OX=9606 GN=KMT2D PE=1 SV=2" "0.000" "False" "57.159" "5" "18" "19" "18" "5537" "593.0" "5.58" "62.17" "18" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "8085" "ENSG00000167548" "KMT2D" "hsa:8085; O14686; O14687" "Histone modifications; 16p11.2 proximal deletion syndrome" "Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function" "8" "0" "1.023" "1.029" "0.965" "1.094" "0.962" "1.087" "0.998" "0.987" "1.004" "940.4" "962.3" "968.1" "907.5" "1029.3" "905.1" "1022.0" "938.4" "927.9" "944.3" "" "" "" "" "" "" "" "" "" "" "845.5" "778.7" "875.6" "885.9" "849.4" "905.1" "765.2" "828.8" "830.3" "337.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6459362278607736604" "False" "High" "IsMasterProtein" "Q9HB07" "MYG1 exonuclease OS=Homo sapiens OX=9606 GN=MYG1 PE=1 SV=4" "0.000" "False" "57.067" "38" "11" "21" "11" "376" "42.5" "6.84" "75.60" "11" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03690" "60314" "ENSG00000139637; ENSG00000291835" "MYG1" "hsa:60314; Q86UA3; Q9HB07" "" "" "0" "0" "1.016" "1.034" "0.998" "1.028" "0.991" "0.993" "1.027" "1.034" "0.920" "1974.3" "2006.6" "2042.2" "1969.8" "2030.6" "1957.5" "1960.0" "2027.3" "2041.0" "1816.2" "" "" "" "" "" "" "" "" "" "" "1775.1" "1623.7" "1847.3" "1922.8" "1675.7" "1957.5" "1467.6" "1790.7" "1826.3" "648.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8210818149912646419" "False" "High" "IsMasterProtein" "P11216" "Glycogen phosphorylase, brain form OS=Homo sapiens OX=9606 GN=PYGB PE=1 SV=5" "0.000" "False" "57.039" "21" "17" "18" "13" "843" "96.6" "6.86" "69.00" "17" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00343" "5834" "ENSG00000100994" "PYGB" "hsa:5834; P11216; Q96AK1; Q9NPX8" "IL-18 signaling pathway; Glycogen synthesis and degradation" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "4" "4" "1.028" "1.014" "1.033" "1.041" "0.950" "1.049" "1.053" "1.057" "0.970" "1735.5" "1784.0" "1760.4" "1792.0" "1806.6" "1648.2" "1820.7" "1827.9" "1833.7" "1682.6" "" "" "" "" "" "" "" "" "" "" "1560.4" "1443.6" "1592.3" "1749.3" "1490.8" "1648.2" "1363.3" "1614.5" "1640.8" "600.6" "14" "14" "14" "14" "14" "14" "14" "14" "14" "14" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6835034816184829460" "False" "High" "IsMasterProtein" "Q13363" "C-terminal-binding protein 1 OS=Homo sapiens OX=9606 GN=CTBP1 PE=1 SV=2" "0.000" "False" "56.976" "27" "11" "28" "7" "440" "47.5" "6.77" "96.98" "11" "protein metabolism;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1487" "ENSG00000159692" "CTBP1" "Q13363; Q4W5N3; Q7Z2Q5" "Notch signaling; Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Pathways affected in adenoid cystic carcinoma; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "SUMOylation of transcription cofactors; Deactivation of the beta-catenin transactivating complex; Repression of WNT target genes; Signaling by TCF7L2 mutants" "14" "5" "0.995" "0.986" "0.933" "1.003" "0.910" "0.964" "0.988" "0.927" "0.816" "3315.0" "3297.0" "3267.5" "3094.3" "3325.9" "3015.4" "3196.7" "3274.3" "3073.4" "2706.5" "" "" "" "" "" "" "" "" "" "" "2980.5" "2667.8" "2955.5" "3020.5" "2744.6" "3015.4" "2393.6" "2892.1" "2750.0" "966.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939378456610215612" "False" "High" "IsMasterProtein" "O95819" "Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP4K4 PE=1 SV=2" "0.000" "False" "56.974" "13" "14" "21" "14" "1239" "142.0" "7.46" "69.15" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00780" "9448" "ENSG00000071054" "MAP4K4" "E7ESS2; hsa:9448; O75172; O95819; Q9NST7" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "Oxidative Stress Induced Senescence" "7" "0" "1.001" "0.953" "0.936" "1.026" "0.961" "0.990" "0.965" "1.012" "1.105" "1153.0" "1154.3" "1099.3" "1079.1" "1183.0" "1108.0" "1141.6" "1112.4" "1166.7" "1273.9" "" "" "" "" "" "" "" "" "" "" "1036.7" "934.0" "994.3" "1053.4" "976.2" "1108.0" "854.8" "982.6" "1044.0" "454.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3353134017530951509" "False" "High" "IsMasterProtein" "Q9Y5K5" "Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Homo sapiens OX=9606 GN=UCHL5 PE=1 SV=3" "0.000" "False" "56.926" "32" "9" "24" "9" "329" "37.6" "5.33" "85.87" "9" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01088, Pf18031" "51377" "ENSG00000116750" "UCHL5" "hsa:51377; Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2; Q9Y5K5" "TGF-beta signaling pathway" "UCH proteinases; Downregulation of TGF-beta receptor signaling" "3" "0" "1.007" "1.015" "0.958" "0.981" "0.979" "1.019" "0.961" "0.967" "1.248" "2338.1" "2355.2" "2373.5" "2239.0" "2294.7" "2289.9" "2382.4" "2247.2" "2260.1" "2917.3" "" "" "" "" "" "" "" "" "" "" "2102.2" "1905.8" "2146.9" "2185.5" "1893.7" "2289.9" "1783.9" "1984.9" "2022.3" "1041.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2463119363191037669" "False" "High" "IsMasterProtein" "Q66LE6" "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform OS=Homo sapiens OX=9606 GN=PPP2R2D PE=1 SV=1" "0.000" "False" "56.871" "22" "10" "18" "3" "453" "52.0" "6.39" "74.80" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "" "55844" "ENSG00000175470" "PPP2R2D" "A8KAK0; hsa:55844; Q5SQJ2; Q66LE6; Q9P1Y7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "MASTL Facilitates Mitotic Progression" "3" "0" "1.046" "0.997" "1.074" "1.007" "0.984" "1.081" "1.103" "1.116" "1.070" "176.4" "184.4" "175.9" "189.5" "177.5" "173.5" "190.6" "194.5" "196.9" "188.7" "" "" "" "" "" "" "" "" "" "" "158.6" "149.2" "159.1" "185.0" "146.5" "173.5" "142.7" "171.8" "176.2" "67.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2599348248423270713" "False" "High" "IsMasterProtein" "P23258" "Tubulin gamma-1 chain OS=Homo sapiens OX=9606 GN=TUBG1 PE=1 SV=2" "0.000" "False" "56.849" "38" "12" "20" "12" "451" "51.1" "6.14" "79.62" "12" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "7283" "ENSG00000131462" "TUBG1" "hsa:7283; P23258; Q53X79; Q9BW59" "Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "0.981" "1.059" "0.976" "1.027" "1.020" "1.046" "0.959" "1.006" "1.247" "858.5" "841.8" "909.0" "838.3" "881.4" "875.7" "898.1" "823.0" "863.4" "1070.2" "" "" "" "" "" "" "" "" "" "" "771.9" "681.2" "822.2" "818.3" "727.3" "875.7" "672.5" "727.0" "772.6" "382.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2621085061721332365" "False" "High" "IsMasterProtein" "P48382" "DNA-binding protein RFX5 OS=Homo sapiens OX=9606 GN=RFX5 PE=1 SV=1" "0.000" "False" "56.842" "23" "12" "17" "12" "616" "65.3" "9.29" "66.45" "12" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf14621, Pf18326" "5993" "ENSG00000143390" "RFX5" "B7Z848; D3DV19; E9PFU4; hsa:5993; P48382; Q5VWC3" "Prion disease pathway; IL-18 signaling pathway" "" "2" "0" "1.001" "0.962" "0.961" "1.040" "0.994" "1.092" "1.036" "0.960" "1.118" "823.8" "824.5" "792.6" "791.8" "856.3" "818.8" "899.6" "853.4" "790.8" "920.6" "" "" "" "" "" "" "" "" "" "" "740.7" "667.2" "717.0" "772.9" "706.7" "818.8" "673.6" "753.8" "707.6" "328.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2633610480889665575" "False" "High" "IsMasterProtein" "O75608" "Acyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=LYPLA1 PE=1 SV=1" "0.000" "False" "56.745" "36" "6" "27" "6" "230" "24.7" "6.77" "106.93" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "10434" "ENSG00000120992" "LYPLA1" "hsa:10434; O43202; O75608; Q9UQF9" "" "RAS processing; eNOS activation" "2" "0" "1.020" "0.997" "1.004" "1.028" "0.973" "1.040" "1.032" "0.984" "0.717" "2997.2" "3056.1" "2986.9" "3008.2" "3082.0" "2916.3" "3116.6" "3092.2" "2949.5" "2148.2" "" "" "" "" "" "" "" "" "" "" "2694.8" "2472.9" "2701.7" "2936.4" "2543.3" "2916.3" "2333.6" "2731.2" "2639.2" "766.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100342078982033337" "False" "High" "IsMasterProtein" "Q8N684" "Cleavage and polyadenylation specificity factor subunit 7 OS=Homo sapiens OX=9606 GN=CPSF7 PE=1 SV=1" "0.000" "False" "56.744" "31" "14" "30" "14" "471" "52.0" "8.00" "85.47" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79869" "ENSG00000149532" "CPSF7" "B3KU04; C9K0Q4; hsa:79869; Q7Z3H9; Q8N684; Q9H025; Q9H9V1" "" "RHOBTB1 GTPase cycle; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.995" "0.984" "0.941" "1.041" "1.075" "1.067" "1.028" "1.132" "0.938" "1840.5" "1832.1" "1811.7" "1732.4" "1916.9" "1978.9" "1964.7" "1891.2" "2084.0" "1725.9" "" "" "" "" "" "" "" "" "" "" "1654.8" "1482.5" "1638.7" "1691.1" "1581.8" "1978.9" "1471.1" "1670.5" "1864.8" "616.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6056381579766233841" "False" "High" "IsMasterProtein" "Q9UNH7" "Sorting nexin-6 OS=Homo sapiens OX=9606 GN=SNX6 PE=1 SV=1" "0.000" "False" "56.726" "38" "14" "18" "13" "406" "46.6" "6.16" "72.62" "14" "transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787, Pf09325" "58533" "ENSG00000129515" "SNX6" "C0H5W9; hsa:58533; Q9UNH7; Q9Y449" "" "" "0" "0" "0.860" "0.849" "0.960" "0.841" "0.767" "0.984" "0.750" "0.723" "2.008" "1999.5" "1718.9" "1697.1" "1918.9" "1681.6" "1533.3" "1967.9" "1499.3" "1445.6" "4015.8" "" "" "" "" "" "" "" "" "" "" "1797.7" "1390.9" "1535.1" "1873.1" "1387.7" "1533.3" "1473.5" "1324.3" "1293.5" "1433.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974134927255505490" "False" "High" "IsMasterProtein" "Q6VY07" "Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens OX=9606 GN=PACS1 PE=1 SV=2" "0.000" "False" "56.706" "18" "15" "17" "15" "963" "104.8" "7.74" "64.44" "15" "other biological processes" "cytosol;ER/Golgi" "other molecular function" "Pf10254" "55690" "ENSG00000175115" "PACS1" "hsa:55690; Q6PJY6; Q6PKB6; Q6VY07; Q7Z590; Q7Z5W4; Q8N8K6; Q96MW0; Q9NW92; Q9ULP5" "" "Nef mediated downregulation of MHC class I complex cell surface expression" "1" "0" "1.029" "1.034" "1.035" "1.069" "1.014" "1.041" "1.003" "1.011" "1.065" "1454.7" "1496.8" "1504.2" "1505.9" "1555.3" "1475.7" "1514.6" "1459.3" "1470.5" "1549.6" "" "" "" "" "" "" "" "" "" "" "1307.9" "1211.1" "1360.6" "1470.0" "1283.5" "1475.7" "1134.1" "1288.9" "1315.8" "553.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3620399161639766887" "False" "High" "IsMasterProtein" "Q99471" "Prefoldin subunit 5 OS=Homo sapiens OX=9606 GN=PFDN5 PE=1 SV=2" "0.000" "False" "56.691" "65" "8" "24" "8" "154" "17.3" "6.33" "93.71" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02996" "5204" "ENSG00000123349; ENSG00000291834" "PFDN5" "A8K9A8; hsa:5204; Q54AA8; Q99471; Q9C083; Q9C084" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.913" "0.911" "0.984" "0.982" "0.935" "0.979" "1.019" "1.003" "0.771" "1731.5" "1580.7" "1577.1" "1704.2" "1699.6" "1618.4" "1694.7" "1764.3" "1736.9" "1335.5" "" "" "" "" "" "" "" "" "" "" "1556.8" "1279.0" "1426.5" "1663.5" "1402.6" "1618.4" "1268.9" "1558.3" "1554.2" "476.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5272844491039920934" "False" "High" "IsMasterProtein" "P09661" "U2 small nuclear ribonucleoprotein A' OS=Homo sapiens OX=9606 GN=SNRPA1 PE=1 SV=2" "0.000" "False" "56.684" "52" "13" "28" "13" "255" "28.4" "8.62" "105.00" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf14580" "6627" "ENSG00000131876" "SNRPA1" "B2R5I6; hsa:6627; P09661; Q8TBD2" "mRNA processing" "mRNA Splicing - Major Pathway; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "3" "0" "1.003" "0.949" "1.011" "0.978" "1.008" "0.972" "0.973" "0.936" "0.830" "2433.8" "2441.7" "2310.3" "2461.7" "2381.2" "2452.1" "2365.9" "2366.9" "2277.2" "2019.9" "" "" "" "" "" "" "" "" "" "" "2188.2" "1975.7" "2089.7" "2402.9" "1965.0" "2452.1" "1771.5" "2090.6" "2037.7" "721.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-938207872866175487" "False" "High" "IsMasterProtein" "Q00534" "Cyclin-dependent kinase 6 OS=Homo sapiens OX=9606 GN=CDK6 PE=1 SV=1" "0.000" "False" "56.646" "42" "12" "26" "11" "326" "36.9" "6.46" "93.86" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1021" "ENSG00000105810" "CDK6" "A4D1G0; hsa:1021; Q00534" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Metastatic brain tumor; Glioblastoma signaling pathways; Retinoblastoma gene in cancer; Wnt signaling pathway; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Influence of laminopathies on Wnt signaling; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity; Regulation of RUNX1 Expression and Activity" "30" "0" "0.987" "0.963" "0.936" "1.012" "0.909" "0.997" "0.974" "0.954" "0.934" "2598.1" "2563.6" "2500.9" "2432.4" "2629.2" "2361.1" "2589.2" "2530.2" "2478.6" "2427.1" "" "" "" "" "" "" "" "" "" "" "2335.9" "2074.4" "2262.1" "2374.4" "2169.6" "2361.1" "1938.8" "2234.8" "2217.8" "866.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1150602487247342071" "False" "High" "IsMasterProtein" "Q92890" "Ubiquitin recognition factor in ER-associated degradation protein 1 OS=Homo sapiens OX=9606 GN=UFD1 PE=1 SV=3" "0.000" "False" "56.604" "49" "11" "18" "11" "307" "34.5" "6.70" "72.78" "11" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03152" "7353" "ENSG00000070010" "UFD1" "A8MW31; hsa:7353; Q92890; Q9Y5N0" "22q11.2 copy number variation syndrome" "Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Translesion Synthesis by POLH" "5" "0" "1.016" "1.045" "1.019" "1.013" "1.088" "1.024" "1.005" "1.046" "0.903" "1494.0" "1517.5" "1560.7" "1522.0" "1514.1" "1625.7" "1529.6" "1501.1" "1563.4" "1349.7" "" "" "" "" "" "" "" "" "" "" "1343.2" "1227.9" "1411.7" "1485.7" "1249.4" "1625.7" "1145.3" "1325.8" "1398.9" "481.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-569299239056590327" "False" "High" "IsMasterProtein" "Q9Y4F9" "Rho family-interacting cell polarization regulator 2 OS=Homo sapiens OX=9606 GN=RIPOR2 PE=1 SV=4" "0.000" "False" "56.462" "15" "15" "24" "14" "1068" "118.4" "5.41" "75.69" "15" "cell adhesion;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf15903" "9750" "ENSG00000111913" "RIPOR2" "A6NHP2; hsa:9750; Q13529; Q5VV37; Q5VV38; Q9BQ28; Q9Y4F9" "" "Sensory processing of sound by outer hair cells of the cochlea; Sensory processing of sound by inner hair cells of the cochlea" "2" "0" "0.968" "0.883" "0.993" "0.990" "0.929" "0.947" "1.013" "0.934" "0.930" "1198.9" "1160.7" "1058.8" "1191.1" "1187.3" "1113.5" "1135.9" "1215.1" "1120.0" "1114.6" "" "" "" "" "" "" "" "" "" "" "1077.9" "939.2" "957.7" "1162.6" "979.8" "1113.5" "850.6" "1073.2" "1002.2" "397.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6922732359213996073" "False" "High" "IsMasterProtein" "Q9H4L7" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 OS=Homo sapiens OX=9606 GN=SMARCAD1 PE=1 SV=2" "0.000" "False" "56.446" "17" "15" "17" "15" "1026" "117.3" "5.55" "67.96" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "56916" "ENSG00000163104" "SMARCAD1" "B7Z799; hsa:56916; Q05D56; Q96SX1; Q9H017; Q9H4L7; Q9H860; Q9NPU9; Q9ULU7" "" "" "0" "0" "1.022" "0.900" "1.012" "1.051" "0.924" "0.970" "1.011" "0.998" "1.252" "1422.0" "1453.2" "1279.9" "1438.3" "1495.1" "1313.4" "1379.8" "1436.9" "1419.6" "1780.0" "" "" "" "" "" "" "" "" "" "" "1278.5" "1175.9" "1157.7" "1404.0" "1233.8" "1313.4" "1033.1" "1269.2" "1270.2" "635.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396121455567897427" "False" "High" "IsMasterProtein" "Q9Y4K1" "Beta/gamma crystallin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CRYBG1 PE=1 SV=4" "0.000" "False" "56.376" "9" "14" "16" "14" "2131" "231.6" "5.81" "70.28" "14" "" "" "other molecular function" "Pf00030, Pf00652" "" "ENSG00000112297" "CRYBG1" "A0A0J9YWL0" "" "" "0" "0" "0.978" "0.954" "0.989" "0.976" "0.987" "1.052" "0.947" "0.929" "1.447" "1738.5" "1699.6" "1658.8" "1720.3" "1697.4" "1715.7" "1829.4" "1647.0" "1615.7" "2516.5" "" "" "" "" "" "" "" "" "" "" "1563.1" "1375.2" "1500.5" "1679.2" "1400.7" "1715.7" "1369.8" "1454.7" "1445.7" "898.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7310593134022698633" "False" "High" "IsMasterProtein" "P57081" "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 OS=Homo sapiens OX=9606 GN=WDR4 PE=1 SV=2" "0.000" "False" "56.328" "37" "10" "15" "10" "412" "45.5" "7.11" "73.46" "10" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00400" "10785" "ENSG00000160193" "WDR4" "A8KA58; B2RCA3; B4DNQ7; D3DSK3; hsa:10785; P57081; Q9BVM5; Q9HCR3" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.051" "1.015" "0.980" "1.024" "0.959" "1.031" "1.046" "0.992" "0.909" "1810.5" "1902.6" "1838.0" "1774.2" "1854.2" "1736.4" "1866.2" "1893.1" "1795.6" "1645.7" "" "" "" "" "" "" "" "" "" "" "1627.8" "1539.5" "1662.5" "1731.8" "1530.1" "1736.4" "1397.4" "1672.1" "1606.7" "587.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3372054881013806202" "False" "High" "IsMasterProtein" "Q9NVZ3" "Adaptin ear-binding coat-associated protein 2 OS=Homo sapiens OX=9606 GN=NECAP2 PE=1 SV=1" "0.000" "False" "56.273" "48" "9" "15" "9" "263" "28.3" "8.38" "72.05" "9" "transport" "other membranes" "" "Pf07933" "55707" "ENSG00000157191; ENSG00000291380" "NECAP2" "B4DY19; E9PGQ8; hsa:55707; Q5VSU4; Q5VSU5; Q9H7L1; Q9H8L1; Q9NVZ3" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.048" "1.064" "1.034" "1.054" "1.114" "1.026" "1.019" "1.090" "0.919" "1072.0" "1123.6" "1140.6" "1108.2" "1129.8" "1194.0" "1100.1" "1092.4" "1168.3" "985.1" "" "" "" "" "" "" "" "" "" "" "963.9" "909.2" "1031.7" "1081.8" "932.4" "1194.0" "823.7" "964.8" "1045.4" "351.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-191513720103364216" "False" "High" "IsMasterProtein" "Q8TAA3" "Proteasome subunit alpha-type 8 OS=Homo sapiens OX=9606 GN=PSMA8 PE=1 SV=3" "0.000" "False" "56.207" "41" "8" "25" "4" "256" "28.5" "8.98" "103.03" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "Pf00227, Pf10584" "143471" "ENSG00000154611" "PSMA8" "B0YJ75; hsa:143471; Q8IVP4; Q8TA98; Q8TAA2; Q8TAA3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; UCH proteinases; ER-Phagosome pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Cross-presentation of soluble exogenous antigens (endosomes); Regulation of ornithine decarboxylase (ODC)" "54" "0" "0.955" "0.967" "0.958" "0.992" "0.900" "0.941" "0.976" "0.993" "0.814" "918.1" "877.1" "887.8" "879.2" "911.2" "826.0" "863.9" "895.9" "911.6" "747.1" "" "" "" "" "" "" "" "" "" "" "825.4" "709.7" "803.0" "858.2" "751.9" "826.0" "646.9" "791.3" "815.7" "266.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2020319621841403457" "False" "High" "IsMasterProtein" "P07741" "Adenine phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=APRT PE=1 SV=2" "0.000" "False" "56.152" "53" "10" "29" "10" "180" "19.6" "6.02" "99.78" "10" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00156" "353" "ENSG00000198931" "APRT" "G5E9J2; hsa:353; P07741; Q3KP55; Q68DF9" "" "Neutrophil degranulation; Purine salvage; Defective APRT disrupts adenine salvage" "3" "0" "1.028" "0.960" "1.045" "1.028" "0.992" "1.009" "1.000" "1.020" "0.820" "1757.3" "1806.0" "1687.5" "1836.0" "1807.2" "1743.8" "1773.3" "1757.6" "1792.4" "1440.6" "" "" "" "" "" "" "" "" "" "" "1580.0" "1461.3" "1526.4" "1792.2" "1491.4" "1743.8" "1327.8" "1552.5" "1603.8" "514.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750059555873910244" "False" "High" "IsMasterProtein" "Q96KB5" "Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens OX=9606 GN=PBK PE=1 SV=3" "0.000" "False" "56.104" "46" "13" "24" "13" "322" "36.1" "5.12" "84.87" "13" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "55872" "ENSG00000168078" "PBK" "B4DX68; D3DST2; hsa:55872; Q96KB5; Q9NPD9; Q9NYL7; Q9NZK6" "4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling" "" "2" "0" "1.057" "1.117" "0.991" "1.058" "1.143" "1.064" "1.037" "1.214" "2.152" "1618.4" "1711.3" "1807.5" "1604.5" "1712.4" "1849.4" "1722.1" "1678.5" "1963.9" "3482.2" "" "" "" "" "" "" "" "" "" "" "1455.1" "1384.7" "1635.0" "1566.2" "1413.1" "1849.4" "1289.5" "1482.5" "1757.3" "1243.1" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4427751732173954290" "False" "High" "IsMasterProtein" "Q99700" "Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2" "0.000" "False" "56.081" "13" "14" "17" "13" "1313" "140.2" "9.57" "70.14" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity" "Pf06741, Pf07145, Pf14438" "6311" "ENSG00000204842" "ATXN2" "A6NLD4; hsa:6311; Q24JQ7; Q6ZQZ7; Q99493; Q99700" "Parkinson's disease pathway; EGF/EGFR signaling pathway" "" "2" "0" "1.029" "1.043" "1.016" "1.018" "1.080" "1.035" "1.095" "0.998" "0.962" "1438.4" "1480.6" "1500.4" "1461.0" "1464.0" "1553.3" "1488.4" "1575.0" "1435.6" "1383.3" "" "" "" "" "" "" "" "" "" "" "1293.2" "1198.0" "1357.2" "1426.2" "1208.1" "1553.3" "1114.5" "1391.2" "1284.5" "493.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4921032794514216116" "False" "High" "IsMasterProtein" "Q8WXX5" "DnaJ homolog subfamily C member 9 OS=Homo sapiens OX=9606 GN=DNAJC9 PE=1 SV=1" "0.000" "False" "55.974" "43" "9" "17" "9" "260" "29.9" "5.73" "67.72" "9" "cell organization and biogenesis;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "23234" "ENSG00000213551" "DNAJC9" "B2RMW6; hsa:23234; Q8WXX5" "" "" "0" "0" "0.947" "1.246" "0.949" "1.031" "1.272" "1.025" "1.083" "1.332" "0.558" "1666.7" "1578.3" "2076.1" "1582.3" "1718.1" "2119.9" "1709.0" "1804.3" "2220.2" "930.8" "" "" "" "" "" "" "" "" "" "" "1498.5" "1277.1" "1877.9" "1544.6" "1417.8" "2119.9" "1279.6" "1593.7" "1986.6" "332.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314773965349869651" "False" "High" "IsMasterProtein" "Q9BRP8" "Partner of Y14 and mago OS=Homo sapiens OX=9606 GN=PYM1 PE=1 SV=1" "0.000" "False" "55.912" "49" "8" "19" "8" "204" "22.6" "9.45" "77.44" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity" "Pf09282" "84305" "ENSG00000170473" "PYM1" "B6ZDM5; hsa:84305; Q8IXJ8; Q8N8E7; Q9BRP8" "TAR syndrome" "" "1" "0" "1.125" "0.957" "0.967" "0.882" "1.033" "0.918" "1.076" "0.849" "0.768" "1561.9" "1756.5" "1494.7" "1509.9" "1377.3" "1613.3" "1433.6" "1680.5" "1325.6" "1199.0" "" "" "" "" "" "" "" "" "" "" "1404.3" "1421.3" "1352.0" "1473.8" "1136.6" "1613.3" "1073.4" "1484.3" "1186.2" "428.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-573717286669998035" "False" "High" "IsMasterProtein" "Q9BY43" "Charged multivesicular body protein 4a OS=Homo sapiens OX=9606 GN=CHMP4A PE=1 SV=3" "0.000" "False" "55.893" "50" "11" "22" "11" "222" "25.1" "4.70" "86.89" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "29082" "ENSG00000254505; ENSG00000285302" "CHMP4A" "hsa:29082; Q14D22; Q32Q79; Q86SZ8; Q96QJ9; Q9BY43; Q9P026" "" "HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.911" "0.922" "0.962" "1.000" "0.961" "0.998" "1.005" "0.938" "0.829" "2355.0" "2145.9" "2171.7" "2266.7" "2356.1" "2262.1" "2350.9" "2365.7" "2208.8" "1951.4" "" "" "" "" "" "" "" "" "" "" "2117.4" "1736.4" "1964.4" "2212.6" "1944.3" "2262.1" "1760.3" "2089.5" "1976.4" "696.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8127348192762311520" "False" "High" "IsMasterProtein" "Q96HN2" "Adenosylhomocysteinase 3 OS=Homo sapiens OX=9606 GN=AHCYL2 PE=1 SV=1" "0.000" "False" "55.848" "25" "16" "31" "5" "611" "66.7" "7.36" "97.96" "16" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00670, Pf05221" "23382" "ENSG00000158467" "AHCYL2" "B4DIZ5; D9N155; hsa:23382; O94917; Q96HN2" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Spina bifida" "Bicarbonate transporters" "4" "0" "1.047" "1.060" "1.007" "1.026" "1.024" "1.039" "1.018" "1.026" "0.802" "678.7" "710.5" "719.2" "683.7" "696.5" "694.9" "705.4" "691.2" "696.1" "544.6" "" "" "" "" "" "" "" "" "" "" "610.2" "574.9" "650.6" "667.4" "574.8" "694.9" "528.2" "610.5" "622.8" "194.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6326411103029325143" "False" "High" "IsMasterProtein" "P53602" "Diphosphomevalonate decarboxylase OS=Homo sapiens OX=9606 GN=MVD PE=1 SV=1" "0.000" "False" "55.779" "29" "12" "22" "12" "400" "43.4" "7.23" "79.03" "12" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00288, Pf18376" "4597" "ENSG00000167508" "MVD" "P53602; Q53Y65" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Aspirin and miRNAs; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis; Synthesis of Dolichyl-phosphate" "11" "0" "1.019" "1.102" "1.007" "1.018" "1.093" "1.062" "1.015" "1.131" "0.854" "1535.1" "1563.7" "1692.4" "1546.3" "1562.4" "1678.3" "1630.3" "1557.4" "1736.8" "1311.0" "" "" "" "" "" "" "" "" "" "" "1380.2" "1265.3" "1530.8" "1509.4" "1289.4" "1678.3" "1220.7" "1375.6" "1554.1" "468.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6099589946817253427" "False" "High" "IsMasterProtein" "Q7Z417" "FMR1-interacting protein NUFIP2 OS=Homo sapiens OX=9606 GN=NUFIP2 PE=1 SV=1" "0.000" "False" "55.773" "21" "11" "20" "11" "695" "76.1" "8.70" "67.71" "11" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15293" "57532" "ENSG00000108256" "NUFIP2" "A1L3A6; A1L3A7; hsa:57532; Q7Z417; Q9P2M5" "" "" "0" "0" "1.003" "1.009" "0.965" "1.023" "1.084" "0.956" "0.979" "1.009" "0.815" "1037.2" "1040.3" "1046.1" "1001.2" "1061.2" "1124.0" "991.5" "1015.5" "1047.1" "845.7" "" "" "" "" "" "" "" "" "" "" "932.6" "841.8" "946.2" "977.3" "875.8" "1124.0" "742.4" "897.0" "936.9" "301.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1723896581553543701" "False" "High" "IsMasterProtein" "Q07666" "KH domain-containing, RNA-binding, signal transduction-associated protein 1 OS=Homo sapiens OX=9606 GN=KHDRBS1 PE=1 SV=1" "0.000" "False" "55.693" "26" "13" "49" "12" "443" "48.2" "8.66" "149.89" "13" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16274, Pf16568" "10657" "ENSG00000121774" "KHDRBS1" "D3DPP3; hsa:10657; Q07666; Q6PJX7; Q8NB97; Q99760" "Leptin signaling pathway; Primary ovarian insufficiency" "PTK6 Regulates Proteins Involved in RNA Processing" "3" "0" "0.993" "0.936" "0.979" "0.920" "0.990" "0.981" "1.006" "0.900" "0.855" "3841.2" "3812.8" "3595.2" "3761.1" "3535.2" "3803.8" "3766.7" "3864.3" "3456.0" "3285.6" "" "" "" "" "" "" "" "" "" "" "3453.6" "3085.2" "3252.0" "3671.4" "2917.3" "3803.8" "2820.4" "3413.2" "3092.4" "1172.9" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3984777124948273039" "False" "High" "IsMasterProtein" "O94903" "Pyridoxal phosphate homeostasis protein OS=Homo sapiens OX=9606 GN=PLPBP PE=1 SV=1" "0.000" "False" "55.667" "36" "10" "25" "10" "275" "30.3" "7.50" "92.18" "10" "" "cytosol;other cell component" "other molecular function" "Pf01168" "11212" "ENSG00000147471" "PLPBP" "O94903; Q6FI94" "" "" "0" "0" "1.022" "1.009" "1.010" "1.063" "1.022" "1.003" "1.044" "1.111" "1.096" "1953.4" "1996.4" "1970.7" "1972.2" "2077.3" "1996.8" "1959.9" "2040.2" "2170.1" "2141.5" "" "" "" "" "" "" "" "" "" "" "1756.3" "1615.4" "1782.6" "1925.2" "1714.2" "1996.8" "1467.5" "1802.1" "1941.8" "764.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524460011519656721" "False" "High" "IsMasterProtein" "P50749" "Ras association domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RASSF2 PE=1 SV=1" "0.000" "False" "55.593" "44" "12" "19" "12" "326" "37.8" "8.84" "73.89" "12" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity" "Pf00788, Pf16517" "9770" "ENSG00000101265" "RASSF2" "A6NIX9; A8K5Z3; hsa:9770; P50749; Q17S06; Q53HD0; Q6AHZ2; Q8IZA5" "Pleural mesothelioma" "" "1" "0" "1.056" "1.177" "1.065" "1.141" "1.171" "1.128" "1.101" "1.206" "2.887" "902.3" "953.0" "1061.6" "960.9" "1029.3" "1056.3" "1017.9" "993.5" "1088.2" "2604.8" "" "" "" "" "" "" "" "" "" "" "811.2" "771.2" "960.3" "938.0" "849.4" "1056.3" "762.1" "877.5" "973.7" "929.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9155703229501675198" "False" "High" "IsMasterProtein" "P31751" "RAC-beta serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT2 PE=1 SV=2" "0.000" "False" "55.579" "34" "15" "21" "11" "481" "55.7" "6.37" "74.18" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "208" "ENSG00000105221" "AKT2" "B2RBD8; hsa:208; P31751; Q05BV0; Q0VAN0; Q0VAN1; Q68GC0" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; S1P receptor signal transduction; Cardiac hypertrophic response; Focal adhesion; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Acute myeloid leukemia; Sildenafil treatment; Female steroid hormones in cardiomyocyte energy metabolism; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; Artemisinin inhibition of uveal melanoma; ErbB signaling pathway; Toll-like receptor signaling pathway" "Deactivation of the beta-catenin transactivating complex; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Regulation of TP53 Degradation; CTLA4 inhibitory signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; CD28 dependent PI3K/Akt signaling; TP53 Regulates Metabolic Genes; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Activation of AKT2; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; FLT3 Signaling; Negative regulation of the PI3K/AKT network; Regulation of TP53 Activity through Acetylation; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; PDE3B signalling; Inhibition of TSC complex formation by PKB" "83" "3" "0.972" "1.023" "0.941" "0.953" "0.932" "0.992" "0.925" "0.959" "1.331" "1633.9" "1588.5" "1671.6" "1537.6" "1557.5" "1523.0" "1621.3" "1511.1" "1567.2" "2175.6" "" "" "" "" "" "" "" "" "" "" "1469.1" "1285.4" "1512.0" "1500.9" "1285.3" "1523.0" "1214.0" "1334.7" "1402.3" "776.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032092853006601019" "False" "High" "IsMasterProtein" "Q13303" "Voltage-gated potassium channel subunit beta-2 OS=Homo sapiens OX=9606 GN=KCNAB2 PE=1 SV=2" "0.000" "False" "55.554" "32" "11" "19" "11" "367" "41.0" "9.00" "70.59" "11" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf00248" "8514" "ENSG00000069424" "KCNAB2" "A0AVM9; A8K1A4; B0AZR7; hsa:8514; O43659; Q13303; Q2YD85; Q5TG82; Q5TG83; Q6ZNE4; Q99411" "Metapathway biotransformation Phase I and II" "Neutrophil degranulation; Voltage gated Potassium channels" "3" "0" "1.030" "0.988" "1.144" "1.002" "1.010" "1.055" "1.013" "1.017" "0.876" "1296.6" "1334.9" "1280.6" "1483.8" "1299.3" "1309.5" "1367.9" "1313.6" "1319.0" "1135.2" "" "" "" "" "" "" "" "" "" "" "1165.7" "1080.2" "1158.4" "1448.4" "1072.2" "1309.5" "1024.2" "1160.3" "1180.3" "405.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5396921561883894054" "False" "High" "IsMasterProtein" "Q96GD0" "Chronophin OS=Homo sapiens OX=9606 GN=PDXP PE=1 SV=2" "0.000" "False" "55.436" "47" "11" "23" "11" "296" "31.7" "6.55" "83.82" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf13242, Pf13344" "57026" "ENSG00000241360" "PDXP" "hsa:57026; Q96GD0; Q9UGY2" "" "" "0" "0" "0.989" "0.994" "0.916" "1.061" "1.004" "1.095" "0.976" "0.988" "0.772" "1115.4" "1102.7" "1108.9" "1022.1" "1183.9" "1120.4" "1221.1" "1089.1" "1102.0" "861.6" "" "" "" "" "" "" "" "" "" "" "1002.9" "892.3" "1003.0" "997.7" "977.0" "1120.4" "914.3" "962.0" "986.1" "307.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777002652342293914" "False" "High" "IsMasterProtein" "Q9H307" "Pinin OS=Homo sapiens OX=9606 GN=PNN PE=1 SV=5" "0.000" "False" "55.422" "24" "15" "21" "14" "717" "81.6" "7.14" "74.78" "15" "cell adhesion;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04696, Pf04697" "5411" "ENSG00000100941" "PNN" "B4DZX8; hsa:5411; O60899; Q53EM7; Q6P5X4; Q7KYL1; Q99738; Q9H307; Q9UHZ9; Q9UQR9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.021" "1.060" "0.983" "1.087" "1.102" "1.099" "1.037" "0.991" "0.849" "1617.4" "1650.7" "1715.1" "1589.5" "1758.8" "1782.0" "1777.9" "1676.7" "1602.3" "1373.2" "" "" "" "" "" "" "" "" "" "" "1454.2" "1335.7" "1551.4" "1551.6" "1451.4" "1782.0" "1331.3" "1480.9" "1433.7" "490.2" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5080369595642031285" "False" "High" "IsMasterProtein" "Q9BVG4" "Protein PBDC1 OS=Homo sapiens OX=9606 GN=PBDC1 PE=1 SV=1" "0.000" "False" "55.399" "42" "10" "17" "10" "233" "26.0" "4.79" "69.33" "10" "" "" "" "Pf04669" "51260" "ENSG00000102390" "PBDC1" "hsa:51260; Q9BVG4" "" "" "0" "0" "0.903" "0.928" "0.919" "0.964" "0.886" "0.993" "0.999" "0.978" "0.871" "2379.3" "2147.5" "2209.2" "2186.4" "2293.5" "2107.2" "2362.1" "2377.5" "2327.4" "2071.4" "" "" "" "" "" "" "" "" "" "" "2139.2" "1737.7" "1998.3" "2134.2" "1892.6" "2107.2" "1768.7" "2100.0" "2082.5" "739.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491921153129945541" "False" "High" "IsMasterProtein" "Q9UHV9" "Prefoldin subunit 2 OS=Homo sapiens OX=9606 GN=PFDN2 PE=1 SV=1" "0.000" "False" "55.363" "53" "7" "21" "7" "154" "16.6" "6.58" "92.61" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5202" "ENSG00000143256" "PFDN2" "hsa:5202; Q9P0P7; Q9UHV9; Q9UN05" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.902" "0.957" "0.911" "1.001" "0.949" "0.963" "0.997" "1.002" "0.807" "2282.1" "2058.8" "2183.1" "2079.4" "2283.6" "2165.7" "2197.8" "2275.2" "2286.0" "1841.4" "" "" "" "" "" "" "" "" "" "" "2051.8" "1665.9" "1974.7" "2029.8" "1884.5" "2165.7" "1645.7" "2009.6" "2045.5" "657.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3363379489977265255" "False" "High" "IsMasterProtein" "P00441" "Superoxide dismutase [Cu-Zn] OS=Homo sapiens OX=9606 GN=SOD1 PE=1 SV=2" "0.000" "False" "55.336" "62" "9" "61" "9" "154" "15.9" "6.13" "236.75" "9" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00080" "6647" "ENSG00000142168" "SOD1" "A6NHJ0; D3DSE4; P00441; Q16669; Q16711; Q16838; Q16839; Q16840; Q6NR85" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; AGE/RAGE pathway; Dopamine metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Copper homeostasis; Physico-chemical features and toxicity-associated pathways; One-carbon metabolism and related pathways; Oxidative stress response; Extracellular vesicles in the crosstalk of cardiac cells; Arsenic metabolism and reactive oxygen species generation; HDAC6 interactions in the central nervous system" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Platelet degranulation ; Detoxification of Reactive Oxygen Species" "17" "0" "0.997" "0.968" "1.039" "0.974" "1.006" "0.980" "1.014" "0.949" "0.865" "3554.3" "3543.5" "3442.3" "3694.5" "3462.6" "3575.9" "3483.2" "3605.3" "3374.0" "3074.2" "" "" "" "" "" "" "" "" "" "" "3195.6" "2867.3" "3113.7" "3606.4" "2857.4" "3575.9" "2608.2" "3184.4" "3019.1" "1097.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5142259406840293622" "False" "High" "IsMasterProtein" "Q14738" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens OX=9606 GN=PPP2R5D PE=1 SV=1" "0.000" "False" "55.302" "23" "13" "21" "10" "602" "69.9" "8.13" "80.17" "13" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5528" "ENSG00000112640" "PPP2R5D" "A8K3I9; B5BUA6; hsa:5528; O00494; O00696; Q14738; Q15171; Q5TC39" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 16p11.2 proximal deletion syndrome; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "RAF activation; Negative regulation of MAPK pathway; Separation of Sister Chromatids; DARPP-32 events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; Platelet sensitization by LDL; CTLA4 inhibitory signaling; PP2A-mediated dephosphorylation of key metabolic factors; ERKs are inactivated" "33" "2" "1.000" "1.006" "0.993" "0.978" "0.945" "1.001" "0.958" "0.980" "1.449" "1534.5" "1534.5" "1544.4" "1523.4" "1500.2" "1450.0" "1535.5" "1470.6" "1504.2" "2223.5" "" "" "" "" "" "" "" "" "" "" "1379.6" "1241.7" "1396.9" "1487.1" "1238.0" "1450.0" "1149.7" "1298.9" "1346.0" "793.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2555536461123867922" "False" "High" "IsMasterProtein" "Q86U90" "Threonylcarbamoyl-AMP synthase OS=Homo sapiens OX=9606 GN=YRDC PE=1 SV=1" "0.000" "False" "55.297" "45" "9" "15" "9" "279" "29.3" "8.57" "59.46" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01300" "79693" "ENSG00000196449" "YRDC" "hsa:79693; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q86U90; Q9H5F8" "" "" "0" "0" "1.064" "1.032" "1.002" "1.087" "1.010" "1.052" "1.054" "1.033" "0.959" "963.5" "1025.5" "994.5" "965.4" "1047.6" "973.4" "1014.0" "1015.2" "995.3" "923.6" "" "" "" "" "" "" "" "" "" "" "866.3" "829.8" "899.6" "942.3" "864.5" "973.4" "759.3" "896.7" "890.6" "329.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4463024331811541084" "False" "High" "IsMasterProtein" "Q15054" "DNA polymerase delta subunit 3 OS=Homo sapiens OX=9606 GN=POLD3 PE=1 SV=2" "0.000" "False" "55.254" "28" "12" "19" "12" "466" "51.4" "9.35" "69.73" "12" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf09507" "10714" "ENSG00000077514" "POLD3" "B7ZAI6; hsa:10714; Q15054; Q32MZ9; Q32N00" "Homologous recombination; Retinoblastoma gene in cancer; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "26" "0" "1.060" "0.934" "1.037" "1.034" "0.905" "1.027" "1.046" "0.937" "1.494" "1931.4" "2046.6" "1804.8" "2002.2" "1997.8" "1747.0" "1983.3" "2020.8" "1808.8" "2886.1" "" "" "" "" "" "" "" "" "" "" "1736.5" "1656.1" "1632.5" "1954.4" "1648.6" "1747.0" "1485.0" "1784.9" "1618.5" "1030.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3241628752191747033" "False" "High" "IsMasterProtein" "Q9Y6W3" "Calpain-7 OS=Homo sapiens OX=9606 GN=CAPN7 PE=1 SV=1" "0.000" "False" "55.231" "19" "14" "18" "14" "813" "92.6" "7.65" "67.01" "14" "protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00648, Pf01067, Pf04212" "23473" "ENSG00000131375" "CAPN7" "hsa:23473; Q9Y6W3" "Integrin-mediated cell adhesion" "Degradation of the extracellular matrix" "2" "0" "0.996" "0.944" "0.991" "0.968" "0.891" "1.035" "0.947" "0.943" "1.115" "1448.7" "1443.6" "1368.1" "1435.8" "1402.8" "1290.8" "1500.2" "1372.5" "1366.1" "1615.6" "" "" "" "" "" "" "" "" "" "" "1302.5" "1168.1" "1237.5" "1401.5" "1157.6" "1290.8" "1123.3" "1212.3" "1222.4" "576.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3251544276452061183" "False" "High" "IsMasterProtein" "P26368" "Splicing factor U2AF 65 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF2 PE=1 SV=4" "0.000" "False" "55.209" "24" "8" "23" "8" "475" "53.5" "9.09" "99.52" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "11338" "ENSG00000063244" "U2AF2" "hsa:11338; P26368; Q96HC5" "mRNA processing; Warburg effect modulated by deubiquitinating enzymes and their substrates" "mRNA Splicing - Major Pathway; Protein hydroxylation; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "7" "0" "1.011" "0.998" "0.955" "1.025" "1.011" "1.001" "0.973" "0.925" "0.778" "1695.9" "1714.4" "1691.8" "1619.7" "1738.8" "1713.9" "1698.1" "1650.9" "1568.8" "1319.0" "" "" "" "" "" "" "" "" "" "" "1524.8" "1387.2" "1530.3" "1581.0" "1434.9" "1713.9" "1271.5" "1458.2" "1403.7" "470.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8005629595719536467" "False" "High" "IsMasterProtein" "Q12840" "Kinesin heavy chain isoform 5A OS=Homo sapiens OX=9606 GN=KIF5A PE=1 SV=2" "0.000" "False" "55.206" "12" "12" "26" "1" "1032" "117.3" "5.90" "92.10" "12" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "3798" "ENSG00000155980" "KIF5A" "A6H8M5; hsa:3798; Q12840; Q4LE26" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Insulin processing; RHO GTPases activate KTN1" "7" "0" "0.996" "0.946" "0.902" "0.901" "0.885" "0.969" "0.955" "0.833" "0.738" "573.5" "571.0" "542.5" "517.4" "517.0" "507.8" "555.8" "547.9" "477.7" "423.2" "" "" "" "" "" "" "" "" "" "" "515.6" "462.0" "490.7" "505.0" "426.6" "507.8" "416.2" "483.9" "427.5" "151.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4480157126328656163" "False" "High" "IsMasterProtein" "O75937" "DnaJ homolog subfamily C member 8 OS=Homo sapiens OX=9606 GN=DNAJC8 PE=1 SV=2" "0.000" "False" "55.204" "36" "11" "39" "11" "253" "29.8" "9.06" "122.24" "11" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf00226" "22826" "ENSG00000126698" "DNAJC8" "B4DUU4; D3DPM0; hsa:22826; O75937; Q6IBA4; Q8N4Z5; Q9P051; Q9P067" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.899" "0.956" "0.928" "0.959" "0.982" "0.966" "1.014" "0.975" "0.834" "5427.6" "4878.8" "5190.4" "5034.4" "5207.0" "5329.1" "5242.0" "5502.7" "5291.1" "4524.7" "" "" "" "" "" "" "" "" "" "" "4880.0" "3947.8" "4694.9" "4914.3" "4297.0" "5329.1" "3925.1" "4860.4" "4734.4" "1615.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4939366548436887845" "False" "High" "IsMasterProtein" "Q7L0Y3" "tRNA methyltransferase 10 homolog C OS=Homo sapiens OX=9606 GN=TRMT10C PE=1 SV=2" "0.000" "False" "55.126" "35" "13" "18" "13" "403" "47.3" "9.36" "64.06" "13" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01746" "54931" "ENSG00000174173" "TRMT10C" "hsa:54931; Q7L0Y3; Q9NRG5; Q9NX54; Q9Y596" "" "tRNA processing in the mitochondrion; tRNA modification in the mitochondrion; rRNA processing in the mitochondrion" "3" "0" "1.048" "0.922" "0.893" "0.976" "0.999" "0.940" "0.988" "0.957" "0.853" "1236.7" "1296.3" "1139.7" "1104.7" "1207.5" "1235.2" "1162.2" "1221.8" "1183.5" "1055.2" "" "" "" "" "" "" "" "" "" "" "1111.9" "1048.9" "1030.9" "1078.3" "996.4" "1235.2" "870.3" "1079.2" "1059.0" "376.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1703725255333180782" "False" "High" "IsMasterProtein" "O14530" "Thioredoxin domain-containing protein 9 OS=Homo sapiens OX=9606 GN=TXNDC9 PE=1 SV=2" "0.000" "False" "55.098" "58" "12" "21" "12" "226" "26.5" "5.88" "81.30" "12" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00085" "10190" "ENSG00000115514" "TXNDC9" "B2R9G8; D3DVI4; hsa:10190; O14530; Q53HG4; Q53RV8; Q6NSF5; Q8TB70; Q9BRU6" "" "" "0" "0" "0.970" "1.050" "1.025" "0.969" "1.026" "1.027" "1.019" "1.027" "0.873" "2769.5" "2686.6" "2907.5" "2839.4" "2683.8" "2842.8" "2844.2" "2821.4" "2843.5" "2418.9" "" "" "" "" "" "" "" "" "" "" "2490.1" "2173.9" "2629.9" "2771.7" "2214.7" "2842.8" "2129.7" "2492.0" "2544.4" "863.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "636638520442762569" "False" "High" "IsMasterProtein" "P54725" "UV excision repair protein RAD23 homolog A OS=Homo sapiens OX=9606 GN=RAD23A PE=1 SV=1" "0.000" "False" "55.097" "29" "8" "26" "6" "363" "39.6" "4.58" "90.90" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00627, Pf09280" "5886" "ENSG00000179262" "RAD23A" "hsa:5886; K7ESE3; P54725; Q59EU8; Q5M7Z1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Josephin domain DUBs; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "6" "0" "0.908" "0.909" "0.920" "0.962" "0.880" "0.960" "0.942" "0.906" "0.780" "1456.0" "1322.4" "1323.4" "1339.1" "1400.2" "1281.9" "1397.4" "1371.3" "1318.5" "1136.2" "" "" "" "" "" "" "" "" "" "" "1309.1" "1070.0" "1197.1" "1307.2" "1155.4" "1281.9" "1046.3" "1211.2" "1179.8" "405.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1698483045954744258" "False" "High" "IsMasterProtein" "Q15018" "BRISC complex subunit Abraxas 2 OS=Homo sapiens OX=9606 GN=ABRAXAS2 PE=1 SV=2" "0.000" "False" "55.090" "33" "12" "17" "12" "415" "46.9" "6.21" "60.17" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf21125" "23172" "ENSG00000165660" "ABRAXAS2" "B4DKR2; hsa:23172; Q15018; Q96H11" "" "Metalloprotease DUBs" "1" "0" "0.937" "0.935" "1.007" "0.968" "1.025" "0.924" "0.992" "0.987" "0.788" "1322.7" "1239.0" "1237.3" "1331.4" "1280.3" "1356.0" "1221.7" "1312.2" "1306.1" "1042.9" "" "" "" "" "" "" "" "" "" "" "1189.2" "1002.6" "1119.2" "1299.7" "1056.6" "1356.0" "914.8" "1159.0" "1168.7" "372.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8650406954565681421" "False" "High" "IsMasterProtein" "P48426" "Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens OX=9606 GN=PIP4K2A PE=1 SV=2" "0.000" "False" "55.080" "33" "12" "19" "8" "406" "46.2" "6.99" "76.07" "12" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "5305" "ENSG00000150867" "PIP4K2A" "B0YJ66; B4DGX2; D3DRV1; hsa:5305; P48426; P53807; Q5VUX3" "Regulation of actin cytoskeleton; G13 signaling pathway" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "4" "0.995" "0.955" "0.975" "1.022" "0.952" "0.946" "0.953" "0.969" "0.945" "2216.4" "2206.2" "2115.8" "2160.0" "2264.8" "2111.0" "2096.4" "2112.7" "2146.8" "2095.4" "" "" "" "" "" "" "" "" "" "" "1992.7" "1785.2" "1913.8" "2108.4" "1869.0" "2111.0" "1569.7" "1866.1" "1921.0" "748.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-204711257539491149" "False" "High" "IsMasterProtein" "O96017" "Serine/threonine-protein kinase Chk2 OS=Homo sapiens OX=9606 GN=CHEK2 PE=1 SV=1" "0.000" "False" "55.035" "26" "12" "18" "12" "543" "60.9" "5.91" "69.63" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00498" "11200" "ENSG00000183765" "CHEK2" "A8K3Y9; B7ZBF3; B7ZBF4; B7ZBF5; hsa:11200; O96017; Q6QA03; Q6QA04; Q6QA05; Q6QA06; Q6QA07; Q6QA08; Q6QA10; Q6QA11; Q6QA12; Q6QA13; Q9HBS5; Q9HCQ8; Q9UGF0; Q9UGF1" "miRNA regulation of DNA damage response; Cell cycle; ATM signaling in development and disease ; miRNA regulation of p53 pathway in prostate cancer; DNA damage response" "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of TP53 Activity through Phosphorylation; Regulation of TP53 Activity through Methylation; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; Stabilization of p53" "13" "0" "1.034" "1.065" "0.988" "1.063" "1.040" "1.031" "1.029" "1.093" "0.962" "1534.8" "1587.6" "1635.0" "1516.2" "1631.2" "1595.8" "1583.1" "1580.0" "1677.4" "1476.3" "" "" "" "" "" "" "" "" "" "" "1379.9" "1284.6" "1478.9" "1480.0" "1346.1" "1595.8" "1185.4" "1395.5" "1500.9" "527.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5135100836873347765" "False" "High" "IsMasterProtein" "Q5T200" "Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens OX=9606 GN=ZC3H13 PE=1 SV=1" "0.000" "False" "55.021" "10" "17" "18" "17" "1668" "196.5" "9.42" "62.34" "17" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00642" "23091" "ENSG00000123200" "ZC3H13" "A2A323; hsa:23091; O94936; Q5T1Z9; Q5T200; Q7Z7J3; Q8NDT6; Q9H0L6" "" "" "0" "0" "0.949" "1.012" "0.920" "0.936" "1.210" "0.987" "0.958" "0.952" "0.725" "932.3" "884.7" "943.5" "857.7" "872.3" "1128.4" "920.1" "892.7" "888.0" "676.3" "" "" "" "" "" "" "" "" "" "" "838.2" "715.8" "853.5" "837.2" "719.8" "1128.4" "688.9" "788.5" "794.5" "241.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8148433569690540229" "False" "High" "IsMasterProtein" "Q96C36" "Pyrroline-5-carboxylate reductase 2 OS=Homo sapiens OX=9606 GN=PYCR2 PE=1 SV=1" "0.000" "False" "54.989" "33" "9" "20" "8" "320" "33.6" "7.77" "80.22" "9" "other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "29920" "ENSG00000143811" "PYCR2" "A8K798; hsa:29920; Q7Z515; Q96C36; Q9Y5J4" "Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "2" "1" "1.037" "1.067" "0.975" "1.027" "1.116" "0.972" "1.063" "1.130" "0.746" "1469.3" "1524.1" "1567.6" "1432.3" "1509.6" "1639.1" "1428.7" "1562.6" "1661.1" "1095.8" "" "" "" "" "" "" "" "" "" "" "1321.1" "1233.3" "1418.0" "1398.1" "1245.8" "1639.1" "1069.8" "1380.2" "1486.3" "391.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4929708673540461466" "False" "High" "IsMasterProtein" "Q9UHP3" "Ubiquitin carboxyl-terminal hydrolase 25 OS=Homo sapiens OX=9606 GN=USP25 PE=1 SV=4" "0.000" "False" "54.934" "15" "15" "18" "15" "1055" "122.1" "5.34" "62.44" "15" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443, Pf02809" "29761" "ENSG00000155313" "USP25" "C0LSZ0; hsa:29761; Q6DHZ9; Q9H9W1; Q9UHP3" "" "Ub-specific processing proteases" "1" "0" "1.020" "0.986" "1.041" "1.040" "1.022" "1.027" "0.998" "0.962" "0.877" "783.2" "798.6" "772.0" "815.5" "814.4" "800.4" "804.1" "781.4" "753.4" "687.0" "" "" "" "" "" "" "" "" "" "" "704.2" "646.2" "698.3" "796.0" "672.0" "800.4" "602.1" "690.2" "674.1" "245.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583280322088088435" "False" "High" "IsMasterProtein" "Q9NPF4" "tRNA N6-adenosine threonylcarbamoyltransferase OS=Homo sapiens OX=9606 GN=OSGEP PE=1 SV=1" "0.000" "False" "54.920" "39" "11" "20" "11" "335" "36.4" "6.35" "83.92" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00814" "55644" "ENSG00000092094; ENSG00000291794" "OSGEP" "hsa:55644; Q6IAC3; Q9NPF4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.000" "1.000" "1.039" "1.028" "1.010" "1.009" "0.980" "1.015" "0.814" "1998.7" "1999.0" "1999.1" "2076.7" "2055.7" "2018.3" "2016.3" "1958.8" "2028.4" "1626.7" "" "" "" "" "" "" "" "" "" "" "1797.1" "1617.6" "1808.3" "2027.1" "1696.4" "2018.3" "1509.8" "1730.1" "1815.0" "580.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7228226931451830335" "False" "High" "IsMasterProtein" "O15084" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Homo sapiens OX=9606 GN=ANKRD28 PE=1 SV=5" "0.000" "False" "54.760" "15" "12" "13" "10" "1053" "112.9" "6.25" "64.21" "12" "" "cytosol;nucleus" "" "Pf00023, Pf12796" "23243" "ENSG00000206560" "ANKRD28" "B4DES5; hsa:23243; O15084; Q1WWL4; Q29RW6; Q3B857; Q6ULS0; Q6ZT57" "" "Telomere Extension By Telomerase; COPII-mediated vesicle transport" "2" "0" "1.030" "0.911" "0.876" "0.988" "0.957" "0.920" "1.010" "0.995" "0.874" "746.2" "768.7" "679.6" "653.7" "737.1" "714.0" "686.5" "753.8" "742.2" "652.0" "" "" "" "" "" "" "" "" "" "" "670.9" "622.0" "614.7" "638.1" "608.3" "714.0" "514.1" "665.8" "664.1" "232.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6332903783671194577" "False" "High" "IsMasterProtein" "P62070" "Ras-related protein R-Ras2 OS=Homo sapiens OX=9606 GN=RRAS2 PE=1 SV=1" "0.000" "False" "54.730" "46" "8" "24" "8" "204" "23.4" "6.01" "82.33" "8" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00071" "22800" "ENSG00000133818" "RRAS2" "B2R9Z3; B7Z5Z2; B7Z6C4; B7Z7H6; hsa:22800; P17082; P62070" "MAPK signaling pathway; Ras signaling; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; EGFR tyrosine kinase inhibitor resistance; Regulation of actin cytoskeleton" "RND1 GTPase cycle" "6" "0" "0.939" "0.973" "0.964" "0.963" "0.963" "0.962" "0.926" "0.965" "0.721" "1827.8" "1717.0" "1778.5" "1761.5" "1760.4" "1760.7" "1758.3" "1692.4" "1763.1" "1317.7" "" "" "" "" "" "" "" "" "" "" "1643.4" "1389.3" "1608.7" "1719.5" "1452.8" "1760.7" "1316.6" "1494.8" "1577.6" "470.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1699378345202944964" "False" "High" "IsMasterProtein" "Q96MX6" "Dynein axonemal assembly factor 10 OS=Homo sapiens OX=9606 GN=DNAAF10 PE=1 SV=1" "0.000" "False" "54.682" "42" "12" "15" "12" "357" "39.7" "8.09" "65.53" "12" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf00400" "116143" "ENSG00000243667" "DNAAF10" "hsa:116143; Q96CR6; Q96MX6" "" "" "0" "0" "1.065" "0.997" "0.948" "1.022" "0.951" "1.004" "0.971" "1.001" "1.058" "1553.7" "1655.3" "1548.9" "1472.6" "1587.7" "1478.1" "1560.2" "1508.4" "1555.6" "1644.6" "" "" "" "" "" "" "" "" "" "" "1396.9" "1339.4" "1401.1" "1437.4" "1310.2" "1478.1" "1168.2" "1332.3" "1391.9" "587.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2458252490920426752" "False" "High" "IsMasterProtein" "P16402" "Histone H1.3 OS=Homo sapiens OX=9606 GN=H1-3 PE=1 SV=2" "0.000" "False" "54.677" "32" "10" "28" "2" "221" "22.3" "11.02" "108.43" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3007" "ENSG00000124575" "H1-3" "B2R751; hsa:3007; P16402; Q2M2I2" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1914895012756735579" "False" "High" "IsMasterProtein" "P08240" "Signal recognition particle receptor subunit alpha OS=Homo sapiens OX=9606 GN=SRPRA PE=1 SV=2" "0.000" "False" "54.636" "23" "14" "22" "14" "638" "69.8" "8.95" "77.36" "14" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00448, Pf02881, Pf04086" "6734" "ENSG00000182934" "SRPRA" "A6NIB3; B2R5Z8; B4E0H3; E9PJS4; hsa:6734; P08240; Q9BVJ4" "" "SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes" "2" "0" "1.114" "1.018" "1.009" "1.099" "1.044" "1.268" "0.976" "0.960" "0.843" "1069.9" "1192.3" "1089.0" "1079.3" "1176.0" "1117.4" "1356.9" "1043.8" "1026.6" "902.4" "" "" "" "" "" "" "" "" "" "" "962.0" "964.8" "985.0" "1053.5" "970.5" "1117.4" "1016.0" "921.9" "918.6" "322.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8993945663539599820" "False" "High" "IsMasterProtein" "P61026" "Ras-related protein Rab-10 OS=Homo sapiens OX=9606 GN=RAB10 PE=1 SV=1" "0.000" "False" "54.606" "55" "12" "37" "9" "200" "22.5" "8.38" "121.16" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "10890" "ENSG00000084733" "RAB10" "D6W538; hsa:10890; O88386; P61026; Q6IA52; Q9D7X6; Q9H0T3" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; Neutrophil degranulation; RAB geranylgeranylation" "5" "0" "1.023" "0.948" "0.938" "1.001" "0.815" "0.937" "0.938" "0.934" "0.801" "1151.0" "1177.7" "1091.3" "1079.5" "1151.9" "937.7" "1078.4" "1079.5" "1075.6" "921.9" "" "" "" "" "" "" "" "" "" "" "1034.8" "953.0" "987.1" "1053.7" "950.6" "937.7" "807.5" "953.5" "962.4" "329.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563010740913614584" "False" "High" "IsMasterProtein" "Q96EB6" "NAD-dependent protein deacetylase sirtuin-1 OS=Homo sapiens OX=9606 GN=SIRT1 PE=1 SV=2" "0.000" "False" "54.541" "26" "15" "17" "15" "747" "81.6" "4.67" "60.90" "15" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23411" "ENSG00000096717" "SIRT1" "hsa:23411; Q2XNF6; Q5JVQ0; Q96EB6; Q9GZR9; Q9Y6F0" "Androgen receptor signaling pathway; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; Melatonin metabolism and effects; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; Interactions between LOXL4 and oxidative stress pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; CAMKK2 pathway; 3q29 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Inclusion body myositis; Prostaglandin and leukotriene metabolism in senescence ; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; 10q11.21q11.23 copy number variation syndrome; TAR syndrome; Omega-6-fatty acids in senescence" "SIRT1 negatively regulates rRNA expression; Regulation of HSF1-mediated heat shock response; Heme signaling; Circadian Clock; Regulation of FOXO transcriptional activity by acetylation" "27" "0" "1.031" "1.100" "1.003" "1.084" "1.116" "0.984" "1.092" "1.157" "0.979" "1193.9" "1230.4" "1313.6" "1197.0" "1294.2" "1331.8" "1175.4" "1303.8" "1381.4" "1168.7" "" "" "" "" "" "" "" "" "" "" "1073.4" "995.6" "1188.2" "1168.4" "1068.0" "1331.8" "880.1" "1151.6" "1236.0" "417.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153241618277291639" "False" "High" "IsMasterProtein" "Q9ULK4" "Mediator of RNA polymerase II transcription subunit 23 OS=Homo sapiens OX=9606 GN=MED23 PE=1 SV=2" "0.000" "False" "54.530" "12" "16" "20" "16" "1368" "156.4" "7.40" "65.03" "16" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11573" "9439" "ENSG00000112282" "MED23" "B9TX55; hsa:9439; O95403; Q5JWT3; Q5JWT4; Q6P9H6; Q9H0J2; Q9NTT9; Q9NTU0; Q9ULK4; Q9Y5P7; Q9Y667" "" "PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway; Transcriptional regulation of white adipocyte differentiation" "4" "0" "1.074" "1.002" "0.927" "1.002" "0.951" "0.998" "0.972" "0.994" "0.966" "911.0" "978.7" "912.8" "844.7" "912.5" "866.0" "908.9" "885.4" "905.7" "879.8" "" "" "" "" "" "" "" "" "" "" "819.0" "792.0" "825.6" "824.6" "753.0" "866.0" "680.6" "782.1" "810.4" "314.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5898955459380036323" "False" "High" "IsMasterProtein" "Q05048" "Cleavage stimulation factor subunit 1 OS=Homo sapiens OX=9606 GN=CSTF1 PE=1 SV=1" "0.000" "False" "54.509" "40" "13" "19" "13" "431" "48.3" "6.58" "71.59" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00400, Pf16699" "1477" "ENSG00000101138" "CSTF1" "hsa:1477; Q05048; Q5QPD8" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "0.994" "1.067" "0.971" "1.061" "0.993" "1.033" "1.015" "1.014" "0.843" "1555.8" "1546.0" "1660.7" "1510.7" "1650.5" "1545.0" "1606.5" "1578.6" "1577.9" "1310.9" "" "" "" "" "" "" "" "" "" "" "1398.9" "1251.0" "1502.2" "1474.6" "1362.0" "1545.0" "1202.9" "1394.3" "1411.9" "467.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5373690399274413822" "False" "High" "IsMasterProtein" "Q8N543" "Prolyl 3-hydroxylase OGFOD1 OS=Homo sapiens OX=9606 GN=OGFOD1 PE=1 SV=1" "0.000" "False" "54.509" "32" "14" "20" "14" "542" "63.2" "5.11" "67.51" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10637, Pf13661" "55239" "ENSG00000087263" "OGFOD1" "H3BUQ2; hsa:55239; Q8N543; Q9H7U5; Q9H9J9; Q9HA87; Q9HCG0; Q9NVB6" "" "Protein hydroxylation" "1" "0" "1.060" "1.104" "1.037" "1.110" "1.089" "1.005" "1.021" "1.104" "1.169" "1654.0" "1752.8" "1825.6" "1714.6" "1836.4" "1801.3" "1662.4" "1688.4" "1826.1" "1933.5" "" "" "" "" "" "" "" "" "" "" "1487.1" "1418.3" "1651.3" "1673.7" "1515.4" "1801.3" "1244.8" "1491.3" "1633.9" "690.2" "15" "15" "15" "15" "15" "15" "15" "15" "15" "15" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8905060599663970094" "False" "High" "IsMasterProtein" "Q9Y5K8" "V-type proton ATPase subunit D OS=Homo sapiens OX=9606 GN=ATP6V1D PE=1 SV=1" "0.000" "False" "54.351" "53" "12" "17" "12" "247" "28.2" "9.36" "69.05" "12" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity" "Pf01813" "51382" "ENSG00000100554" "ATP6V1D" "B2RE33; hsa:51382; Q9Y5K8; Q9Y688" "Proximal tubule transport" "Neutrophil degranulation; Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.063" "1.055" "1.005" "1.090" "1.049" "1.058" "1.054" "1.106" "0.886" "1096.1" "1165.1" "1156.1" "1101.4" "1194.3" "1149.5" "1159.7" "1155.4" "1212.0" "971.1" "" "" "" "" "" "" "" "" "" "" "985.5" "942.7" "1045.7" "1075.1" "985.5" "1149.5" "868.3" "1020.5" "1084.5" "346.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3913128170310311305" "False" "High" "IsMasterProtein" "O00487" "26S proteasome non-ATPase regulatory subunit 14 OS=Homo sapiens OX=9606 GN=PSMD14 PE=1 SV=1" "0.000" "False" "54.309" "39" "11" "31" "11" "310" "34.6" "6.52" "109.14" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398" "10213" "ENSG00000115233" "PSMD14" "B3KNW2; hsa:10213; O00176; O00487" "Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Antigen processing: Ubiquitination & Proteasome degradation; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Neutrophil degranulation; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Metalloprotease DUBs" "64" "0" "0.955" "0.985" "0.967" "0.957" "0.938" "0.998" "0.977" "0.987" "0.760" "3390.9" "3237.5" "3339.3" "3277.6" "3245.1" "3181.4" "3385.5" "3312.5" "3348.0" "2577.9" "" "" "" "" "" "" "" "" "" "" "3048.7" "2619.6" "3020.5" "3199.4" "2677.9" "3181.4" "2535.0" "2925.8" "2995.7" "920.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2840679928359396214" "False" "High" "IsMasterProtein" "Q6P1N0" "Coiled-coil and C2 domain-containing protein 1A OS=Homo sapiens OX=9606 GN=CC2D1A PE=1 SV=1" "0.000" "False" "54.244" "19" "15" "18" "14" "951" "104.0" "8.09" "68.26" "15" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "54862" "ENSG00000132024; ENSG00000288293" "CC2D1A" "hsa:54862; Q6P1N0; Q7Z435; Q86XV0; Q8NF89; Q9H603; Q9NXI1" "Sudden infant death syndrome (SIDS) susceptibility pathways" "" "1" "1" "0.983" "0.985" "0.974" "0.993" "1.035" "1.011" "0.963" "1.026" "1.085" "1471.2" "1446.9" "1448.6" "1432.8" "1460.5" "1523.1" "1486.8" "1416.3" "1509.3" "1596.8" "" "" "" "" "" "" "" "" "" "" "1322.8" "1170.8" "1310.3" "1398.6" "1205.2" "1523.1" "1113.3" "1250.9" "1350.5" "570.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4234558439794556747" "False" "High" "IsMasterProtein" "Q8N6H7" "ADP-ribosylation factor GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=ARFGAP2 PE=1 SV=1" "0.000" "False" "54.231" "29" "15" "21" "15" "521" "56.7" "7.99" "72.34" "15" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "84364" "ENSG00000149182" "ARFGAP2" "B4DX29; B7Z9M7; D3DQQ9; hsa:84364; Q3LIF2; Q8N3I1; Q8N6H7; Q96SX7" "IL-18 signaling pathway; 5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; CDC42 GTPase cycle" "5" "0" "0.966" "1.007" "0.988" "1.015" "1.053" "0.981" "1.041" "1.053" "1.058" "1856.9" "1794.1" "1869.6" "1834.3" "1885.2" "1954.8" "1822.1" "1932.1" "1956.0" "1965.3" "" "" "" "" "" "" "" "" "" "" "1669.5" "1451.7" "1691.1" "1790.5" "1555.7" "1954.8" "1364.4" "1706.6" "1750.2" "701.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7391762605629829309" "False" "High" "IsMasterProtein" "O95801" "Tetratricopeptide repeat protein 4 OS=Homo sapiens OX=9606 GN=TTC4 PE=1 SV=3" "0.000" "False" "54.230" "36" "13" "19" "13" "387" "44.7" "5.60" "69.20" "13" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf18972" "7268" "ENSG00000243725" "TTC4" "hsa:7268; O95801; Q53Y95; Q5TA96; Q9H3I2" "" "" "0" "0" "0.981" "1.003" "1.008" "1.010" "1.005" "0.961" "1.029" "1.018" "1.269" "2080.3" "2041.2" "2086.7" "2097.6" "2100.4" "2090.2" "1999.3" "2140.7" "2118.0" "2640.2" "" "" "" "" "" "" "" "" "" "" "1870.4" "1651.7" "1887.5" "2047.5" "1733.3" "2090.2" "1497.1" "1890.8" "1895.1" "942.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7480340352347879805" "False" "High" "IsMasterProtein" "Q99459" "Cell division cycle 5-like protein OS=Homo sapiens OX=9606 GN=CDC5L PE=1 SV=2" "0.000" "False" "54.213" "21" "14" "19" "14" "802" "92.2" "8.18" "67.83" "14" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11831, Pf13921" "988" "ENSG00000096401" "CDC5L" "hsa:988; Q76N46; Q99459; Q99974" "" "mRNA Splicing - Major Pathway" "1" "0" "0.985" "1.008" "0.999" "0.996" "1.125" "1.061" "0.943" "0.965" "2.870" "727.3" "716.5" "733.4" "726.9" "724.4" "818.2" "771.9" "685.7" "701.9" "2087.3" "" "" "" "" "" "" "" "" "" "" "654.0" "579.8" "663.4" "709.5" "597.8" "818.2" "578.0" "605.6" "628.0" "745.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7071014728097244949" "False" "High" "IsMasterProtein" "Q9BW27" "Nuclear pore complex protein Nup85 OS=Homo sapiens OX=9606 GN=NUP85 PE=1 SV=1" "0.000" "False" "54.207" "24" "13" "17" "13" "656" "75.0" "5.55" "60.70" "13" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07575" "79902" "ENSG00000125450" "NUP85" "B4DMQ3; B4DPW1; hsa:79902; Q8NDI4; Q9BW27; Q9H9U1" "" "Separation of Sister Chromatids; Transport of Mature mRNA derived from an Intron-Containing Transcript; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SUMOylation of DNA replication proteins; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.056" "1.027" "1.000" "1.045" "1.074" "1.079" "0.975" "0.997" "0.852" "1573.6" "1662.3" "1615.5" "1574.0" "1644.9" "1689.7" "1698.4" "1534.6" "1569.5" "1341.1" "" "" "" "" "" "" "" "" "" "" "1414.8" "1345.1" "1461.3" "1536.5" "1357.4" "1689.7" "1271.7" "1355.5" "1404.3" "478.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7747633478491734615" "False" "High" "IsMasterProtein" "Q96BW5" "Phosphotriesterase-related protein OS=Homo sapiens OX=9606 GN=PTER PE=1 SV=1" "0.000" "False" "54.185" "40" "13" "16" "13" "349" "39.0" "6.52" "67.06" "13" "other metabolic processes;other biological processes" "" "other molecular function" "Pf02126" "9317" "ENSG00000165983" "PTER" "B0YJ77; B3KTF5; D3DRU0; hsa:9317; Q96BW5; Q9BY46" "" "" "0" "0" "0.992" "1.005" "0.978" "1.000" "0.972" "1.000" "0.958" "0.986" "0.818" "1717.1" "1702.6" "1726.4" "1679.0" "1717.6" "1668.3" "1716.8" "1645.1" "1692.6" "1404.6" "" "" "" "" "" "" "" "" "" "" "1543.8" "1377.7" "1561.6" "1639.0" "1417.4" "1668.3" "1285.5" "1453.1" "1514.5" "501.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010766793389346536" "False" "High" "IsMasterProtein" "P0DP25" "Calmodulin-3 OS=Homo sapiens OX=9606 GN=CALM3 PE=1 SV=1" "0.000" "False" "54.175" "37" "6" "79" "6" "149" "16.8" "4.22" "294.46" "6" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf13499" "801; 805; 808" "ENSG00000160014" "CALM3" "hsa:801; hsa:805; hsa:808; P02593; P0DP25; P62158; P70667; P99014; Q13942; Q53S29; Q61379; Q61380; Q96HK3" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Myometrial relaxation and contraction pathways; G protein signaling pathways; Ras signaling; Melanoma; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; Glycogen synthesis and degradation; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; G13 signaling pathway; Calcium regulation in cardiac cells" "" "17" "0" "1.021" "0.990" "1.081" "0.967" "1.034" "1.011" "1.060" "0.979" "0.895" "7700.3" "7865.5" "7625.2" "8327.1" "7444.9" "7960.2" "7788.5" "8161.9" "7542.4" "6889.7" "" "" "" "" "" "" "" "" "" "" "6923.3" "6364.5" "6897.3" "8128.4" "6143.7" "7960.2" "5831.9" "7209.1" "6748.9" "2459.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2821733550000515702" "False" "High" "IsMasterProtein" "Q9NX46" "ADP-ribosylhydrolase ARH3 OS=Homo sapiens OX=9606 GN=ADPRS PE=1 SV=1" "0.000" "False" "54.112" "36" "10" "21" "10" "363" "38.9" "5.07" "76.51" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03747" "54936" "ENSG00000116863" "ADPRS" "hsa:54936; Q53G94; Q6IAB8; Q9BY47; Q9NX46" "" "POLB-Dependent Long Patch Base Excision Repair" "1" "0" "0.957" "0.996" "0.963" "1.000" "0.994" "0.964" "0.984" "0.990" "0.869" "1195.6" "1143.9" "1190.8" "1151.2" "1195.6" "1189.0" "1152.4" "1176.8" "1183.2" "1039.2" "" "" "" "" "" "" "" "" "" "" "1075.0" "925.6" "1077.1" "1123.7" "986.6" "1189.0" "862.9" "1039.4" "1058.8" "370.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948435004993003441" "False" "High" "IsMasterProtein" "P52594" "Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=AGFG1 PE=1 SV=2" "0.000" "False" "54.110" "24" "11" "18" "11" "562" "58.2" "8.63" "77.55" "11" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01412" "3267" "ENSG00000173744" "AGFG1" "B3KUL1; E9PHX7; hsa:3267; P52594; Q15277; Q4VAS0; Q4VAS1; Q4VAS3; Q53QT8; Q53R11" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "0.967" "0.912" "0.952" "1.017" "0.968" "1.042" "0.989" "0.976" "0.862" "1307.7" "1265.0" "1192.4" "1245.1" "1329.8" "1265.5" "1363.1" "1293.9" "1276.6" "1127.5" "" "" "" "" "" "" "" "" "" "" "1175.7" "1023.6" "1078.6" "1215.4" "1097.4" "1265.5" "1020.6" "1142.9" "1142.3" "402.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1880293335037512275" "False" "High" "IsMasterProtein" "E9PAV3" "Nascent polypeptide-associated complex subunit alpha, muscle-specific form OS=Homo sapiens OX=9606 GN=NACA PE=1 SV=1" "0.000" "False" "54.033" "3" "5" "33" "5" "2078" "205.3" "9.58" "112.60" "5" "other biological processes" "translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01849, Pf19026" "" "ENSG00000196531" "NACA" "E9PAV3" "" "" "0" "0" "0.902" "0.967" "1.035" "0.956" "0.887" "0.948" "0.938" "0.956" "0.746" "3207.0" "2892.8" "3102.3" "3320.0" "3064.8" "2843.1" "3039.7" "3008.8" "3066.3" "2393.7" "" "" "" "" "" "" "" "" "" "" "2883.4" "2340.7" "2806.1" "3240.8" "2529.1" "2843.1" "2276.1" "2657.6" "2743.7" "854.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4228584982071455131" "False" "High" "IsMasterProtein" "Q92769" "Histone deacetylase 2 OS=Homo sapiens OX=9606 GN=HDAC2 PE=1 SV=2" "0.000" "False" "53.887" "26" "11" "26" "6" "488" "55.3" "5.91" "84.57" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850" "3066" "ENSG00000196591" "HDAC2" "B3KRS5; B4DL58; E1P561; hsa:3066; Q5SRI8; Q5SZ86; Q8NEH4; Q92769" "Cell cycle; Neural crest differentiation; Notch signaling; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Effect of progerin on genes involved in progeria; Ciliary landscape; 7q11.23 copy number variation syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; TAR syndrome; Notch signaling pathway" "Regulation of TP53 Activity through Acetylation; Potential therapeutics for SARS; SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Regulation of PTEN gene transcription; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Factors involved in megakaryocyte development and platelet production; RNA Polymerase I Transcription Initiation; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Regulation of MECP2 expression and activity; STAT3 nuclear events downstream of ALK signaling; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; EGR2 and SOX10-mediated initiation of Schwann cell myelination; MECP2 regulates neuronal receptors and channels" "30" "0" "0.998" "1.126" "0.921" "1.025" "1.012" "1.082" "0.982" "0.983" "1.072" "1027.9" "1025.4" "1157.2" "947.1" "1053.4" "1040.2" "1112.1" "1009.2" "1010.5" "1101.9" "" "" "" "" "" "" "" "" "" "" "924.2" "829.7" "1046.8" "924.5" "869.3" "1040.2" "832.7" "891.4" "904.2" "393.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119671646432562357" "False" "High" "IsMasterProtein" "P13929" "Beta-enolase OS=Homo sapiens OX=9606 GN=ENO3 PE=1 SV=5" "0.000" "False" "53.885" "22" "6" "57" "1" "434" "47.0" "7.71" "270.14" "6" "other metabolic processes" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00113, Pf03952" "2027" "ENSG00000108515" "ENO3" "B4DUI6; B4DUM6; D3DTL2; E7ENK8; hsa:2027; P13929; Q96AE2" "Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1319936172901890664" "False" "High" "IsMasterProtein" "P45973" "Chromobox protein homolog 5 OS=Homo sapiens OX=9606 GN=CBX5 PE=1 SV=1" "0.000" "False" "53.844" "51" "8" "18" "7" "191" "22.2" "5.86" "70.91" "8" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00385, Pf01393" "23468" "ENSG00000094916" "CBX5" "B2R8T9; hsa:23468; P45973" "Effect of progerin on genes involved in progeria; 22q11.2 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; SUMOylation of chromatin organization proteins; Transcriptional Regulation by E2F6" "5" "0" "1.030" "0.931" "1.021" "1.063" "1.023" "1.042" "1.074" "0.948" "0.844" "1817.2" "1872.1" "1691.9" "1855.1" "1932.3" "1858.8" "1892.7" "1952.5" "1722.5" "1534.3" "" "" "" "" "" "" "" "" "" "" "1633.8" "1514.8" "1530.4" "1810.8" "1594.6" "1858.8" "1417.2" "1724.5" "1541.3" "547.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3980314117452886183" "False" "High" "IsMasterProtein" "P62979" "Ubiquitin-ribosomal protein eS31 fusion protein OS=Homo sapiens OX=9606 GN=RPS27A PE=1 SV=2" "0.000" "False" "53.805" "50" "8" "183" "1" "156" "18.0" "9.64" "573.64" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01599" "6233" "ENSG00000143947" "RPS27A" "hsa:6233; P02248; P02249; P02250; P14798; P62979; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BQ77; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Cargo recognition for clathrin-mediated endocytosis; Stimuli-sensing channels; Negative regulation of MAPK pathway; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Orc1 removal from chromatin; Assembly of the pre-replicative complex; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; KEAP1-NFE2L2 pathway; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of PLK1 Activity at G2/M Transition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Peroxisomal protein import; Regulation of TP53 Degradation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Circadian Clock; Regulation of signaling by CBL; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; Cyclin D associated events in G1; APC/C:Cdc20 mediated degradation of Cyclin B; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Interferon alpha/beta signaling; Inactivation of CSF3 (G-CSF) signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; HDR through Homologous Recombination (HRR); Signaling by CSF1 (M-CSF) in myeloid cells; NOTCH1 Intracellular Domain Regulates Transcription; TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; Regulation of innate immune responses to cytosolic DNA; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "203" "6" "0.951" "0.954" "0.953" "0.915" "0.941" "0.895" "0.957" "0.888" "0.918" "12849.4" "12223.6" "12253.4" "12251.4" "11757.5" "12088.5" "11494.2" "12296.7" "11415.6" "11789.9" "" "" "" "" "" "" "" "" "" "" "11552.9" "9890.9" "11083.6" "11959.0" "9702.5" "12088.5" "8606.5" "10861.2" "10214.6" "4208.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5775237487534858758" "False" "High" "IsMasterProtein" "P62750" "Large ribosomal subunit protein uL23 OS=Homo sapiens OX=9606 GN=RPL23A PE=1 SV=1" "0.000" "False" "53.777" "44" "9" "25" "9" "156" "17.7" "10.45" "74.23" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00276, Pf03939" "6147" "ENSG00000198242" "RPL23A" "B2R5B2; hsa:6147; P29316; P39024; P62750; Q92774" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.953" "0.974" "0.918" "0.955" "1.031" "0.921" "0.922" "0.961" "0.770" "2188.5" "2086.4" "2132.7" "2008.3" "2090.9" "2255.8" "2015.7" "2018.8" "2102.3" "1684.2" "" "" "" "" "" "" "" "" "" "" "1967.7" "1688.3" "1929.1" "1960.3" "1725.5" "2255.8" "1509.3" "1783.1" "1881.2" "601.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4163681238843766636" "False" "High" "IsMasterProtein" "Q13144" "Translation initiation factor eIF2B subunit epsilon OS=Homo sapiens OX=9606 GN=EIF2B5 PE=1 SV=3" "0.000" "False" "53.770" "21" "11" "18" "11" "721" "80.3" "5.08" "67.33" "11" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf02020" "8893" "ENSG00000145191" "EIF2B5" "hsa:8893; Q13144; Q541Z1; Q96D04" "Translation factors; MicroRNAs in cardiomyocyte hypertrophy; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "0.988" "0.990" "0.946" "1.015" "0.933" "0.932" "0.947" "0.964" "0.914" "1039.8" "1027.4" "1029.3" "983.4" "1055.1" "969.7" "968.9" "984.5" "1001.9" "950.4" "" "" "" "" "" "" "" "" "" "" "934.9" "831.3" "931.0" "959.9" "870.7" "969.7" "725.5" "869.6" "896.5" "339.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5860856138791644160" "False" "High" "IsMasterProtein" "Q9Y5A9" "YTH domain-containing family protein 2 OS=Homo sapiens OX=9606 GN=YTHDF2 PE=1 SV=2" "0.000" "False" "53.745" "22" "13" "22" "10" "579" "62.3" "8.79" "83.64" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04146" "51441" "ENSG00000198492" "YTHDF2" "A6NKG4; A8K966; B4E1G7; D3DPM8; hsa:51441; Q5VSZ9; Q8TDH0; Q9BUJ5; Q9Y5A9" "" "" "0" "3" "1.000" "1.014" "1.057" "0.982" "1.062" "1.025" "1.002" "1.017" "0.885" "2311.1" "2311.0" "2343.6" "2443.1" "2269.2" "2454.2" "2367.9" "2316.9" "2349.8" "2044.6" "" "" "" "" "" "" "" "" "" "" "2077.9" "1870.0" "2119.9" "2384.9" "1872.6" "2454.2" "1773.1" "2046.4" "2102.6" "729.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1528073227460313936" "False" "High" "IsMasterProtein" "Q9H9T3" "Elongator complex protein 3 OS=Homo sapiens OX=9606 GN=ELP3 PE=1 SV=2" "0.000" "False" "53.565" "27" "14" "17" "14" "547" "62.2" "8.88" "60.79" "14" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04055, Pf16199" "55140" "ENSG00000134014" "ELP3" "B4DE19; B4DIG1; E2QRI5; hsa:55140; Q53G84; Q6AWB0; Q9BVF7; Q9H9T3; Q9NVZ1" "Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system" "HATs acetylate histones" "3" "0" "1.015" "0.982" "0.930" "1.033" "0.935" "0.966" "0.937" "1.007" "0.853" "1080.0" "1096.3" "1060.9" "1004.9" "1115.9" "1010.4" "1043.2" "1012.4" "1087.2" "921.2" "" "" "" "" "" "" "" "" "" "" "971.1" "887.1" "959.7" "980.9" "920.9" "1010.4" "781.1" "894.2" "972.8" "328.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2128989799875943394" "False" "High" "IsMasterProtein" "Q92888" "Rho guanine nucleotide exchange factor 1 OS=Homo sapiens OX=9606 GN=ARHGEF1 PE=1 SV=2" "0.000" "False" "53.503" "22" "17" "18" "17" "912" "102.4" "5.66" "58.49" "17" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00621, Pf09128, Pf17838" "9138" "ENSG00000076928" "ARHGEF1" "hsa:9138; O00513; Q6NX52; Q8N4J4; Q92888; Q96BF4; Q96F17; Q9BSB1" "G protein signaling pathways; EGF/EGFR signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "9" "0" "1.035" "0.987" "0.944" "1.041" "0.965" "0.984" "0.895" "0.962" "2.801" "1048.7" "1085.9" "1035.5" "990.1" "1091.3" "1011.6" "1032.1" "938.3" "1009.0" "2937.0" "" "" "" "" "" "" "" "" "" "" "942.9" "878.7" "936.6" "966.5" "900.6" "1011.6" "772.8" "828.7" "902.9" "1048.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631666065222226929" "False" "High" "IsMasterProtein" "P42898" "Methylenetetrahydrofolate reductase (NADPH) OS=Homo sapiens OX=9606 GN=MTHFR PE=1 SV=3" "0.000" "False" "53.497" "24" "13" "19" "13" "656" "74.5" "5.34" "72.34" "13" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf02219" "4524" "ENSG00000177000" "MTHFR" "B2R7A6; hsa:4524; P42898; Q5SNW6; Q5SNW9; Q7Z6M6; Q8IU73; Q9UQR2" "Glycine metabolism; Selenium micronutrient network; Vitamin B12 metabolism; Folate-alcohol and cancer pathway hypotheses; Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways; Ethanol effects on histone modifications; MTHFR deficiency; Male infertility; Spina bifida" "Metabolism of folate and pterines" "14" "0" "0.978" "1.021" "0.983" "1.041" "0.985" "1.024" "0.992" "1.019" "0.888" "1801.8" "1762.4" "1839.5" "1770.5" "1876.0" "1774.0" "1844.4" "1787.3" "1836.0" "1600.8" "" "" "" "" "" "" "" "" "" "" "1620.0" "1426.0" "1663.9" "1728.3" "1548.1" "1774.0" "1381.1" "1578.6" "1642.9" "571.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588374002070682198" "False" "High" "IsMasterProtein" "P63000" "Ras-related C3 botulinum toxin substrate 1 OS=Homo sapiens OX=9606 GN=RAC1 PE=1 SV=1" "0.000" "False" "53.496" "41" "9" "33" "4" "192" "21.4" "8.50" "112.99" "9" "cell adhesion;cell-cell signaling;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5879" "ENSG00000136238" "RAC1" "hsa:5879; O95501; P15154; P63000; Q3Y4D3; Q5JAA8; Q9BTB4" "Androgen receptor signaling pathway; Nucleotide-binding oligomerization domain (NOD) pathway; Target of rapamycin signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; RalA downstream regulated genes; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Cardiac hypertrophic response; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Robo4 and VEGF signaling pathways crosstalk; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Ciliary landscape; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Hippo signaling regulation pathways; Leukocyte-intrinsic Hippo pathway functions; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Netrin-UNC5B signaling pathway; Insulin signaling; CAMKK2 pathway; Opioid receptor pathways; Regulation of actin cytoskeleton; GDNF signaling; 2q13 copy number variation syndrome; 2q21.1 copy number variation syndrome; 2q37 copy number variation syndrome; G13 signaling pathway; Genetic causes of porto-sinusoidal vascular disease; TROP2 regulatory signaling; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling; RAC1 GTPase cycle; NRAGE signals death through JNK; DCC mediated attractive signaling; Neutrophil degranulation; FCERI mediated MAPK activation; MAPK6/MAPK4 signaling; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; Signaling by SCF-KIT; DAP12 signaling; Ephrin signaling; Factors involved in megakaryocyte development and platelet production; RHO GTPases activate CIT; PCP/CE pathway; WNT5:FZD7-mediated leishmania damping; EPH-ephrin mediated repulsion of cells; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Signal transduction by L1; RHO GTPases activate PKNs; RHO GTPases activate PAKs; DSCAM interactions; Azathioprine ADME; VEGFR2 mediated vascular permeability; Sema4D mediated inhibition of cell attachment and migration; Inactivation of CDC42 and RAC1; Activation of RAC1; CD28 dependent Vav1 pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Nef and signal transduction; RHO GTPases Activate NADPH Oxidases; NTRK2 activates RAC1; MET activates RAP1 and RAC1; Activation of RAC1 downstream of NMDARs; Activated NTRK2 signals through CDK5; RHO GTPases activate KTN1" "113" "0" "0.969" "0.978" "1.027" "0.926" "0.967" "0.909" "0.984" "0.945" "0.799" "1579.8" "1530.9" "1545.3" "1622.2" "1462.6" "1528.2" "1435.7" "1554.3" "1493.2" "1261.7" "" "" "" "" "" "" "" "" "" "" "1420.4" "1238.8" "1397.8" "1583.5" "1206.9" "1528.2" "1075.0" "1372.9" "1336.1" "450.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2475503787040523239" "False" "High" "IsMasterProtein" "Q9UM54" "Unconventional myosin-VI OS=Homo sapiens OX=9606 GN=MYO6 PE=1 SV=4" "0.000" "False" "53.487" "13" "13" "16" "13" "1294" "149.6" "8.53" "59.86" "13" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf16521, Pf21521" "4646" "ENSG00000196586" "MYO6" "A6H8V4; E1P540; hsa:4646; Q5TEM5; Q5TEM6; Q5TEM7; Q9BZZ7; Q9UEG2; Q9UM54" "VEGFA-VEGFR2 signaling; Joubert syndrome" "RHOU GTPase cycle; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle; Trafficking of AMPA receptors; Gap junction degradation" "7" "0" "1.039" "1.070" "1.036" "1.108" "1.085" "1.058" "1.039" "1.097" "1.135" "1077.1" "1119.1" "1152.5" "1115.4" "1193.1" "1168.7" "1139.4" "1119.0" "1181.7" "1222.9" "" "" "" "" "" "" "" "" "" "" "968.5" "905.6" "1042.5" "1088.8" "984.6" "1168.7" "853.2" "988.4" "1057.4" "436.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5403362594162546688" "False" "High" "IsMasterProtein" "Q15007" "Pre-mRNA-splicing regulator WTAP OS=Homo sapiens OX=9606 GN=WTAP PE=1 SV=2" "0.000" "False" "53.425" "32" "12" "18" "12" "396" "44.2" "5.19" "76.64" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf17098" "9589" "ENSG00000146457" "WTAP" "hsa:9589; Q15007; Q5TCL8; Q5TCL9; Q96T28; Q9BYJ7; Q9H4E2" "" "Processing of Capped Intron-Containing Pre-mRNA" "1" "0" "0.939" "1.026" "0.925" "0.970" "1.109" "0.997" "0.922" "0.970" "0.807" "2058.7" "1932.2" "2111.4" "1904.7" "1996.4" "2283.4" "2051.8" "1897.4" "1996.9" "1660.6" "" "" "" "" "" "" "" "" "" "" "1850.9" "1563.4" "1909.8" "1859.2" "1647.5" "2283.4" "1536.4" "1675.9" "1786.8" "592.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8788472230308956" "False" "High" "IsMasterProtein" "Q8NCW5" "NAD(P)H-hydrate epimerase OS=Homo sapiens OX=9606 GN=NAXE PE=1 SV=2" "0.000" "False" "53.416" "40" "10" "21" "10" "288" "31.7" "7.66" "74.58" "10" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;mitochondrion;other cell component" "other molecular function" "Pf03853" "128240" "ENSG00000163382" "NAXE" "B4DGY3; hsa:128240; Q496C6; Q5T3I2; Q8NCW5" "" "Nicotinamide salvaging" "1" "0" "0.988" "1.012" "0.997" "1.015" "0.995" "0.991" "1.027" "1.036" "0.817" "1696.9" "1676.8" "1716.7" "1692.0" "1723.0" "1689.2" "1681.4" "1743.0" "1758.2" "1387.1" "" "" "" "" "" "" "" "" "" "" "1525.7" "1356.8" "1552.8" "1651.6" "1421.8" "1689.2" "1259.0" "1539.5" "1573.2" "495.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8205566320687520923" "False" "High" "IsMasterProtein" "Q9NSK0" "Kinesin light chain 4 OS=Homo sapiens OX=9606 GN=KLC4 PE=1 SV=3" "0.000" "False" "53.387" "26" "15" "18" "11" "619" "68.6" "6.18" "62.12" "15" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf13374, Pf13424" "89953" "ENSG00000137171" "KLC4" "B3KNY4; B3KPI3; B3KSQ3; B4DME9; hsa:89953; Q66K28; Q96EG6; Q9NSK0" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; RHO GTPases activate KTN1" "6" "0" "1.004" "0.951" "0.969" "0.985" "0.937" "1.051" "0.967" "0.929" "1.169" "941.1" "945.3" "894.9" "911.8" "926.8" "881.3" "989.2" "909.6" "874.4" "1100.6" "" "" "" "" "" "" "" "" "" "" "846.1" "764.9" "809.5" "890.0" "764.8" "881.3" "740.7" "803.4" "782.4" "392.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376641896775859350" "False" "High" "IsMasterProtein" "O95104" "SR-related and CTD-associated factor 4 OS=Homo sapiens OX=9606 GN=SCAF4 PE=1 SV=3" "0.000" "False" "53.300" "12" "12" "17" "9" "1147" "125.8" "9.55" "63.14" "12" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "57466" "ENSG00000156304" "SCAF4" "C9JLZ0; hsa:57466; O95104; Q0P5W8; Q6P1M5; Q8N3I8; Q9UFM1; Q9ULP8" "" "" "0" "3" "1.049" "1.156" "0.969" "0.994" "1.105" "1.075" "0.961" "1.016" "1.655" "1883.8" "1976.5" "2176.9" "1824.9" "1871.7" "2081.2" "2025.8" "1809.6" "1914.4" "3118.0" "" "" "" "" "" "" "" "" "" "" "1693.7" "1599.3" "1969.1" "1781.4" "1544.5" "2081.2" "1516.9" "1598.3" "1713.0" "1113.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5940813161561783541" "False" "High" "IsMasterProtein" "Q9H078" "Mitochondrial disaggregase OS=Homo sapiens OX=9606 GN=CLPB PE=1 SV=1" "0.000" "False" "53.292" "24" "15" "17" "15" "707" "78.7" "9.01" "63.63" "15" "stress response;signal transduction;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf07724, Pf10431, Pf12796" "81570" "ENSG00000162129" "CLPB" "B4DXJ7; B4DXP7; B4DXW4; E7EWN6; F8W7P6; hsa:81570; Q8ND11; Q9H078; Q9H8Y0" "" "" "0" "0" "1.062" "1.063" "0.997" "1.037" "1.138" "1.055" "1.073" "1.026" "0.864" "1000.2" "1062.6" "1062.8" "997.7" "1037.6" "1138.1" "1055.7" "1073.7" "1026.6" "864.1" "" "" "" "" "" "" "" "" "" "" "899.3" "859.8" "961.3" "973.9" "856.2" "1138.1" "790.5" "948.3" "918.6" "308.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2662746858814386989" "False" "High" "IsMasterProtein" "Q15024" "Exosome complex component RRP42 OS=Homo sapiens OX=9606 GN=EXOSC7 PE=1 SV=3" "0.000" "False" "53.285" "44" "11" "20" "11" "291" "31.8" "5.19" "69.06" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "23016" "ENSG00000075914" "EXOSC7" "hsa:23016; Q15024; Q96E72" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.008" "1.073" "1.024" "1.059" "0.982" "1.018" "1.023" "1.098" "0.650" "1367.5" "1378.6" "1467.8" "1401.0" "1448.7" "1342.6" "1391.8" "1398.3" "1501.8" "888.6" "" "" "" "" "" "" "" "" "" "" "1229.5" "1115.6" "1327.7" "1367.5" "1195.5" "1342.6" "1042.1" "1235.1" "1343.8" "317.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3635452200201599036" "False" "High" "IsMasterProtein" "Q12904" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Homo sapiens OX=9606 GN=AIMP1 PE=1 SV=2" "0.000" "False" "53.215" "42" "10" "24" "9" "312" "34.3" "8.43" "91.99" "10" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf01588" "9255" "ENSG00000164022" "AIMP1" "B3KTR2; B4E1S7; hsa:9255; Q12904; Q6FG28; Q96CQ9" "Ciliary landscape" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "3" "0" "0.977" "1.032" "1.063" "0.971" "1.037" "1.045" "0.954" "1.077" "2.740" "2169.8" "2120.0" "2239.5" "2305.7" "2105.8" "2249.5" "2267.1" "2070.3" "2336.1" "5945.5" "" "" "" "" "" "" "" "" "" "" "1950.9" "1715.4" "2025.7" "2250.7" "1737.8" "2249.5" "1697.5" "1828.6" "2090.4" "2122.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3257917255703740656" "False" "High" "IsMasterProtein" "Q14181" "DNA polymerase alpha subunit B OS=Homo sapiens OX=9606 GN=POLA2 PE=1 SV=2" "0.000" "False" "53.214" "25" "12" "17" "12" "598" "65.9" "5.24" "67.45" "12" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus" "nucleic acid binding activity" "Pf04042, Pf08418" "23649" "ENSG00000014138" "POLA2" "B4DNB4; hsa:23649; Q14181; Q9BPV3" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "1.102" "1.084" "0.975" "1.131" "1.040" "1.045" "1.058" "1.096" "1.511" "1023.8" "1128.5" "1109.5" "998.7" "1158.3" "1064.7" "1069.6" "1082.8" "1122.3" "1547.5" "" "" "" "" "" "" "" "" "" "" "920.5" "913.2" "1003.6" "974.8" "955.9" "1064.7" "800.9" "956.4" "1004.2" "552.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8070677658803742602" "False" "High" "IsMasterProtein" "P20585" "DNA mismatch repair protein Msh3 OS=Homo sapiens OX=9606 GN=MSH3 PE=1 SV=4" "0.000" "False" "53.109" "14" "16" "16" "16" "1137" "127.3" "8.02" "58.31" "16" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00488, Pf01624, Pf05188, Pf05192" "4437" "ENSG00000113318" "MSH3" "A1L480; A1L482; A6NMM6; hsa:4437; P20585; Q6PJT5; Q86UQ6; Q92867" "Chromosomal and microsatellite instability in colorectal cancer ; DNA repair pathways, full network" "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MSH3; Defective Mismatch Repair Associated With MSH2" "5" "0" "1.030" "0.949" "0.989" "1.041" "0.898" "1.051" "0.935" "0.912" "1.280" "1054.8" "1086.0" "1000.6" "1043.7" "1098.3" "947.4" "1108.9" "986.1" "962.4" "1350.2" "" "" "" "" "" "" "" "" "" "" "948.4" "878.7" "905.1" "1018.8" "906.3" "947.4" "830.3" "871.0" "861.1" "482.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580197304848334652" "False" "High" "IsMasterProtein" "Q13496" "Myotubularin OS=Homo sapiens OX=9606 GN=MTM1 PE=1 SV=2" "0.000" "False" "53.105" "21" "12" "16" "12" "603" "69.9" "8.18" "51.05" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "4534" "ENSG00000171100" "MTM1" "A6NDB1; B7Z491; F2Z330; hsa:4534; Q13496; Q8NEL1" "" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "0.988" "0.961" "0.959" "1.018" "0.966" "0.968" "0.958" "0.997" "0.864" "1362.5" "1346.0" "1309.4" "1307.0" "1386.7" "1316.3" "1318.8" "1304.6" "1358.4" "1177.8" "" "" "" "" "" "" "" "" "" "" "1225.0" "1089.1" "1184.4" "1275.8" "1144.3" "1316.3" "987.5" "1152.3" "1215.5" "420.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869916031675078190" "False" "High" "IsMasterProtein" "O95486" "Protein transport protein Sec24A OS=Homo sapiens OX=9606 GN=SEC24A PE=1 SV=2" "0.000" "False" "53.099" "16" "15" "19" "14" "1093" "119.7" "7.66" "69.98" "15" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10802" "ENSG00000113615" "SEC24A" "A8MVW3; hsa:10802; O95486; Q8WUV2; Q96GP7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "1" "1.091" "1.043" "0.990" "1.122" "1.003" "1.089" "1.039" "1.052" "0.969" "686.3" "748.8" "715.8" "679.2" "770.1" "688.1" "747.7" "712.8" "721.7" "665.0" "" "" "" "" "" "" "" "" "" "" "617.0" "605.9" "647.5" "663.0" "635.5" "688.1" "559.8" "629.6" "645.8" "237.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574193745658390357" "False" "High" "IsMasterProtein" "P46926" "Glucosamine-6-phosphate isomerase 1 OS=Homo sapiens OX=9606 GN=GNPDA1 PE=1 SV=1" "0.000" "False" "53.096" "48" "11" "17" "6" "289" "32.6" "6.92" "66.59" "11" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01182" "10007" "ENSG00000113552" "GNPDA1" "B7Z3X4; D3DQE7; hsa:10007; P46926" "" "Glycolysis" "1" "6" "1.046" "1.083" "1.006" "1.068" "0.991" "1.014" "1.026" "1.046" "0.831" "1638.2" "1713.9" "1773.6" "1648.3" "1749.3" "1623.5" "1660.8" "1681.0" "1714.1" "1362.2" "" "" "" "" "" "" "" "" "" "" "1472.9" "1386.8" "1604.3" "1609.0" "1443.6" "1623.5" "1243.6" "1484.8" "1533.7" "486.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8488452650529328010" "False" "High" "IsMasterProtein" "Q5VIR6" "Vacuolar protein sorting-associated protein 53 homolog OS=Homo sapiens OX=9606 GN=VPS53 PE=1 SV=2" "0.000" "False" "53.087" "21" "16" "20" "16" "832" "94.3" "6.70" "68.04" "16" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04100, Pf16854" "55275" "ENSG00000141252; ENSG00000283883" "VPS53" "A8K2S8; B3FH42; hsa:55275; Q5VIR6; Q8WYW3; Q9BRR2; Q9BY02; Q9NV25" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.027" "0.976" "0.964" "0.990" "0.923" "1.004" "0.979" "0.974" "1.112" "1777.4" "1824.9" "1734.1" "1713.9" "1759.8" "1640.4" "1784.3" "1740.0" "1730.9" "1975.7" "" "" "" "" "" "" "" "" "" "" "1598.1" "1476.7" "1568.6" "1673.0" "1452.2" "1640.4" "1336.0" "1536.8" "1548.8" "705.3" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "692688187917917011" "False" "High" "IsMasterProtein" "P82979" "SAP domain-containing ribonucleoprotein OS=Homo sapiens OX=9606 GN=SARNP PE=1 SV=3" "0.000" "False" "52.824" "47" "9" "31" "9" "210" "23.7" "6.42" "107.24" "9" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037" "84324" "ENSG00000205323" "SARNP" "A8K393; hsa:84324; P82979; Q9P066" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.921" "0.957" "0.960" "0.922" "0.981" "0.956" "1.017" "0.922" "0.765" "4723.3" "4352.0" "4521.8" "4536.1" "4353.8" "4635.3" "4513.2" "4804.2" "4353.9" "3614.6" "" "" "" "" "" "" "" "" "" "" "4246.7" "3521.5" "4090.1" "4427.8" "3592.8" "4635.3" "3379.4" "4243.4" "3895.8" "1290.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1860975273197737865" "False" "High" "IsMasterProtein" "P19784" "Casein kinase II subunit alpha' OS=Homo sapiens OX=9606 GN=CSNK2A2 PE=1 SV=1" "0.000" "False" "52.751" "39" "11" "19" "10" "350" "41.2" "8.56" "72.49" "11" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1459" "ENSG00000070770" "CSNK2A2" "hsa:1459; P19784" "Alzheimer's disease and miRNA effects; Allograft rejection; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of TP53 Activity through Phosphorylation; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Condensation of Prometaphase Chromosomes; Synthesis of PC" "21" "0" "1.085" "1.031" "1.006" "1.142" "1.098" "1.030" "0.992" "1.094" "1.210" "1218.0" "1322.0" "1256.0" "1225.8" "1390.3" "1337.5" "1254.4" "1207.6" "1333.0" "1473.6" "" "" "" "" "" "" "" "" "" "" "1095.1" "1069.7" "1136.1" "1196.5" "1147.3" "1337.5" "939.3" "1066.6" "1192.7" "526.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4497117085705849008" "False" "High" "IsMasterProtein" "Q9UHY1" "Nuclear receptor-binding protein OS=Homo sapiens OX=9606 GN=NRBP1 PE=1 SV=1" "0.000" "False" "52.707" "24" "10" "16" "10" "535" "59.8" "5.08" "69.27" "10" "transport" "other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "29959" "ENSG00000115216" "NRBP1" "B3KV40; D6W558; hsa:29959; Q53FZ5; Q96SU3; Q9UHY1" "" "Nuclear Receptor transcription pathway" "1" "0" "1.091" "1.027" "1.035" "1.091" "1.028" "1.027" "1.034" "1.042" "0.960" "1359.4" "1483.4" "1396.6" "1406.5" "1482.6" "1397.9" "1395.5" "1405.1" "1416.8" "1305.5" "" "" "" "" "" "" "" "" "" "" "1222.2" "1200.3" "1263.2" "1372.9" "1223.5" "1397.9" "1044.9" "1241.1" "1267.8" "466.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158883592383283846" "False" "High" "IsMasterProtein" "P60983" "Glia maturation factor beta OS=Homo sapiens OX=9606 GN=GMFB PE=1 SV=2" "0.000" "False" "52.697" "44" "7" "23" "6" "142" "16.7" "5.29" "95.46" "7" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "2764" "ENSG00000197045" "GMFB" "B2R499; hsa:2764; P17774; P60983; Q9BS35" "" "" "0" "1" "0.964" "0.982" "0.946" "0.993" "0.976" "0.934" "0.983" "1.005" "0.768" "3028.8" "2919.3" "2975.8" "2865.9" "3008.9" "2957.5" "2829.3" "2977.8" "3043.8" "2327.0" "" "" "" "" "" "" "" "" "" "" "2723.2" "2362.2" "2691.7" "2797.5" "2483.0" "2957.5" "2118.5" "2630.2" "2723.6" "830.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6481945204603063978" "False" "High" "IsMasterProtein" "Q9UBB6" "Neurochondrin OS=Homo sapiens OX=9606 GN=NCDN PE=1 SV=1" "0.000" "False" "52.624" "21" "12" "17" "12" "729" "78.8" "5.48" "59.09" "12" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf05536" "23154" "ENSG00000020129" "NCDN" "D3DPR9; hsa:23154; Q9UBB6; Q9UBY2; Q9Y4A6; Q9Y4D9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "1.102" "1.219" "0.975" "1.120" "1.109" "1.080" "1.070" "1.102" "1.100" "673.0" "741.4" "820.0" "656.1" "753.5" "746.3" "726.6" "720.1" "741.9" "740.4" "" "" "" "" "" "" "" "" "" "" "605.1" "599.9" "741.7" "640.5" "621.8" "746.3" "544.1" "636.0" "663.8" "264.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4088167174397650062" "False" "High" "IsMasterProtein" "Q9BV20" "Methylthioribose-1-phosphate isomerase OS=Homo sapiens OX=9606 GN=MRI1 PE=1 SV=1" "0.000" "False" "52.531" "37" "12" "22" "12" "369" "39.1" "6.30" "71.23" "12" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01008" "84245" "ENSG00000037757" "MRI1" "hsa:84245; Q8NDC9; Q9BV20" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "0.998" "0.968" "0.956" "0.990" "0.938" "0.941" "0.976" "0.999" "0.835" "2127.1" "2123.9" "2058.4" "2034.0" "2106.3" "1994.3" "2001.9" "2076.4" "2124.5" "1776.5" "" "" "" "" "" "" "" "" "" "" "1912.5" "1718.6" "1861.9" "1985.5" "1738.2" "1994.3" "1499.0" "1834.0" "1901.0" "634.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8360736340109521171" "False" "High" "IsMasterProtein" "P57737" "Coronin-7 OS=Homo sapiens OX=9606 GN=CORO7 PE=1 SV=2" "0.000" "False" "52.529" "16" "11" "17" "11" "925" "100.5" "5.80" "62.47" "11" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity" "Pf00400, Pf08953, Pf16300" "79585" "ENSG00000262246; ENSG00000282725" "CORO7" "B4DFD6; B4DL18; hsa:79585; I3L416; P57737; Q17RK4" "" "" "0" "0" "1.087" "1.106" "1.062" "1.106" "1.001" "1.103" "1.052" "1.102" "3.545" "732.8" "796.9" "810.4" "778.3" "810.3" "733.9" "808.6" "770.7" "807.5" "2597.8" "" "" "" "" "" "" "" "" "" "" "658.9" "644.8" "733.0" "759.7" "668.7" "733.9" "605.5" "680.8" "722.6" "927.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7224643183628006691" "False" "High" "IsMasterProtein" "O00303" "Eukaryotic translation initiation factor 3 subunit F OS=Homo sapiens OX=9606 GN=EIF3F PE=1 SV=1" "0.000" "False" "52.521" "31" "10" "22" "10" "357" "37.5" "5.45" "78.09" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01398, Pf13012" "8665" "ENSG00000175390" "EIF3F" "A8K0S2; hsa:8665; O00303; Q6IB45; Q8N978" "Translation factors; VEGFA-VEGFR2 signaling; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "9" "0" "1.081" "1.056" "1.015" "1.030" "1.085" "1.057" "1.046" "1.101" "1.355" "1568.7" "1696.2" "1655.9" "1592.5" "1615.3" "1702.0" "1657.6" "1640.9" "1727.9" "2124.9" "" "" "" "" "" "" "" "" "" "" "1410.4" "1372.5" "1497.8" "1554.5" "1333.0" "1702.0" "1241.2" "1449.3" "1546.1" "758.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2326963864063357056" "False" "High" "IsMasterProtein" "O95202" "Mitochondrial proton/calcium exchanger protein OS=Homo sapiens OX=9606 GN=LETM1 PE=1 SV=1" "0.000" "False" "52.487" "22" "13" "20" "13" "739" "83.3" "6.70" "66.93" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;translation activity;other molecular function" "Pf07766" "3954" "ENSG00000168924" "LETM1" "B4DED2; hsa:3954; O95202; Q9UF65" "4p16.3 copy number variation" "RHOG GTPase cycle; Mitochondrial calcium ion transport" "3" "0" "0.999" "1.002" "1.048" "1.148" "1.048" "1.272" "1.039" "0.940" "0.710" "1188.6" "1187.9" "1190.9" "1245.5" "1364.9" "1246.2" "1511.5" "1235.1" "1117.1" "844.4" "" "" "" "" "" "" "" "" "" "" "1068.7" "961.2" "1077.2" "1215.7" "1126.4" "1246.2" "1131.8" "1090.9" "999.6" "301.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2660523182149503333" "False" "High" "IsMasterProtein" "Q9UKK9" "ADP-sugar pyrophosphatase OS=Homo sapiens OX=9606 GN=NUDT5 PE=1 SV=1" "0.000" "False" "52.435" "51" "9" "27" "9" "219" "24.3" "4.94" "112.35" "9" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00293" "11164" "ENSG00000165609" "NUDT5" "A8K516; hsa:11164; Q6IAG0; Q9UH49; Q9UKK9" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "1.038" "1.023" "1.093" "1.057" "1.001" "1.014" "1.007" "1.056" "0.857" "3050.2" "3164.8" "3119.0" "3334.3" "3225.5" "3053.2" "3093.3" "3072.6" "3221.0" "2615.2" "" "" "" "" "" "" "" "" "" "" "2742.4" "2560.9" "2821.3" "3254.7" "2661.7" "3053.2" "2316.2" "2714.0" "2882.1" "933.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145009283245857027" "False" "High" "IsMasterProtein" "P62487" "DNA-directed RNA polymerase II subunit RPB7 OS=Homo sapiens OX=9606 GN=POLR2G PE=1 SV=1" "0.000" "False" "52.372" "49" "7" "19" "7" "172" "19.3" "5.54" "70.87" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00575, Pf03876" "5436" "ENSG00000168002" "POLR2G" "B2R5C0; hsa:5436; P52433; P62487; Q2M1Z4" "Pyrimidine metabolism; Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "1.040" "1.054" "0.937" "1.036" "1.036" "0.990" "1.049" "1.042" "0.838" "1792.6" "1864.8" "1888.9" "1680.3" "1856.8" "1857.6" "1774.0" "1880.6" "1868.2" "1502.1" "" "" "" "" "" "" "" "" "" "" "1611.7" "1508.9" "1708.6" "1640.2" "1532.3" "1857.6" "1328.3" "1661.0" "1671.7" "536.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8461791288305677895" "False" "High" "IsMasterProtein" "Q92783" "Signal transducing adapter molecule 1 OS=Homo sapiens OX=9606 GN=STAM PE=1 SV=3" "0.000" "False" "52.365" "28" "12" "15" "10" "540" "59.1" "4.82" "60.81" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00790, Pf02809" "8027" "ENSG00000136738" "STAM" "B0YJ99; D3DRU5; hsa:8027; Q8N6D9; Q92783" "Vitamin D receptor pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Endosomal Sorting Complex Required For Transport (ESCRT); RHOU GTPase cycle; Metalloprotease DUBs; Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "11" "0" "0.949" "0.995" "0.945" "0.980" "0.976" "0.976" "0.986" "1.018" "0.798" "1372.6" "1302.6" "1366.0" "1297.3" "1344.7" "1340.3" "1340.0" "1353.6" "1396.9" "1094.8" "" "" "" "" "" "" "" "" "" "" "1234.1" "1054.0" "1235.6" "1266.4" "1109.7" "1340.3" "1003.4" "1195.6" "1249.9" "390.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "250780751349012114" "False" "High" "IsMasterProtein" "Cont_Q29443" "Serotransferrin OS=Bos taurus OX=9913 GN=TF PE=2 SV=1" "0.000" "True" "52.342" "24" "14" "18" "14" "704" "77.7" "7.08" "67.33" "14" "stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00405" "280705" "" "TF" "bta:280705; Q0IIK2; Q29443" "" "" "0" "0" "0.990" "1.041" "1.033" "1.082" "1.007" "1.079" "1.040" "0.996" "0.937" "1009.4" "999.0" "1051.3" "1042.4" "1091.8" "1016.6" "1089.0" "1049.9" "1005.7" "946.2" "" "" "" "" "" "" "" "" "" "" "907.6" "808.4" "950.9" "1017.5" "901.0" "1016.6" "815.4" "927.4" "899.9" "337.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6811152372553307115" "False" "High" "IsMasterProtein" "Q9Y2X3" "Nucleolar protein 58 OS=Homo sapiens OX=9606 GN=NOP58 PE=1 SV=1" "0.000" "False" "52.259" "22" "11" "18" "11" "529" "59.5" "8.92" "67.02" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "51602" "ENSG00000055044" "NOP58" "hsa:51602; Q53SA4; Q6PK08; Q9P036; Q9UFN3; Q9Y2X3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; SUMOylation of RNA binding proteins; rRNA modification in the nucleus and cytosol" "3" "0" "1.004" "1.000" "0.913" "1.021" "0.994" "0.983" "0.952" "1.001" "0.907" "2318.6" "2328.0" "2317.9" "2117.1" "2366.1" "2304.6" "2278.5" "2208.2" "2320.7" "2102.4" "" "" "" "" "" "" "" "" "" "" "2084.6" "1883.7" "2096.6" "2066.6" "1952.6" "2304.6" "1706.1" "1950.4" "2076.5" "750.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173318319984318675" "False" "High" "IsMasterProtein" "Q9BXR0" "Queuine tRNA-ribosyltransferase catalytic subunit 1 OS=Homo sapiens OX=9606 GN=QTRT1 PE=1 SV=3" "0.000" "False" "52.225" "27" "10" "17" "10" "403" "44.0" "7.23" "64.90" "10" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01702" "81890" "ENSG00000213339" "QTRT1" "B4DFM7; hsa:81890; Q96BQ4; Q9BXQ9; Q9BXR0" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.043" "1.048" "1.027" "1.044" "1.106" "1.046" "1.042" "1.064" "0.919" "1793.7" "1870.4" "1879.3" "1842.9" "1873.4" "1983.6" "1876.7" "1868.4" "1908.2" "1648.1" "" "" "" "" "" "" "" "" "" "" "1612.7" "1513.4" "1699.9" "1799.0" "1545.9" "1983.6" "1405.2" "1650.3" "1707.4" "588.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869717489525171844" "False" "High" "IsMasterProtein" "O60306" "RNA helicase aquarius OS=Homo sapiens OX=9606 GN=AQR PE=1 SV=4" "0.000" "False" "52.224" "11" "14" "16" "14" "1485" "171.2" "6.37" "59.92" "14" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf16399, Pf21143, Pf21144" "9716" "ENSG00000021776" "AQR" "A0JP17; A5YKK3; hsa:9716; O60306; Q2YDX9; Q6IRU8; Q6PIC8" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "1.006" "1.058" "0.936" "1.045" "1.006" "0.931" "1.015" "0.995" "1.348" "930.7" "936.7" "984.7" "871.4" "972.3" "936.1" "866.9" "944.3" "926.3" "1254.5" "" "" "" "" "" "" "" "" "" "" "836.8" "757.9" "890.7" "850.6" "802.4" "936.1" "649.1" "834.0" "828.9" "447.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8114162095880212588" "False" "High" "IsMasterProtein" "Q9H3S7" "Tyrosine-protein phosphatase non-receptor type 23 OS=Homo sapiens OX=9606 GN=PTPN23 PE=1 SV=1" "0.000" "False" "52.216" "10" "16" "17" "16" "1636" "178.9" "6.92" "57.41" "16" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102, Pf03097, Pf13949" "25930" "ENSG00000076201" "PTPN23" "A8K0D7; hsa:25930; Q7KZF8; Q8N6Z5; Q9BSR5; Q9H3S7; Q9P257; Q9UG03; Q9UMZ4" "" "Interleukin-37 signaling" "1" "0" "0.987" "1.017" "0.950" "1.006" "0.986" "0.980" "0.951" "0.990" "1.069" "918.9" "906.6" "934.5" "873.4" "924.4" "906.2" "900.2" "874.2" "909.8" "982.6" "" "" "" "" "" "" "" "" "" "" "826.2" "733.6" "845.3" "852.5" "762.8" "906.2" "674.0" "772.2" "814.1" "350.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8736083768290238180" "False" "High" "IsMasterProtein" "Cont_P13647" "Keratin, type II cytoskeletal 5 OS=Homo sapiens OX=9606 GN=KRT5 PE=1 SV=3" "0.000" "True" "52.191" "23" "16" "20" "7" "590" "62.3" "7.74" "68.46" "16" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;cytoskeletal activity;other molecular function" "Pf00038, Pf16208" "3852" "ENSG00000186081" "KRT5" "hsa:3852; P13647; Q6PI71; Q6UBJ0; Q8TA91" "" "Formation of the cornified envelope; Type I hemidesmosome assembly" "3" "1" "0.367" "0.441" "0.612" "0.384" "1.486" "1.130" "0.746" "0.576" "1.538" "908.4" "333.8" "400.4" "555.9" "349.1" "1349.7" "1026.2" "678.0" "522.8" "1396.7" "" "" "" "" "" "" "" "" "" "" "816.7" "270.1" "362.1" "542.7" "288.1" "1349.7" "768.4" "598.9" "467.8" "498.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6030770174415932169" "False" "High" "IsMasterProtein" "P52294" "Importin subunit alpha-5 OS=Homo sapiens OX=9606 GN=KPNA1 PE=1 SV=3" "0.000" "False" "52.182" "23" "12" "21" "6" "538" "60.2" "5.01" "79.68" "12" "cell-cell signaling;cell cycle OR cell proliferation;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "3836" "ENSG00000114030" "KPNA1" "D3DN93; hsa:3836; P52294; Q6IBQ9; Q9BQ56" "Ebola virus infection in host" "Apoptosis induced DNA fragmentation; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Interferon alpha/beta signaling; Assembly of the ORC complex at the origin of replication; Integration of provirus; Inhibition of nitric oxide production" "10" "3" "0.972" "0.904" "0.945" "0.981" "0.913" "1.000" "0.978" "0.913" "1.991" "876.1" "851.6" "792.0" "827.5" "859.5" "799.9" "876.1" "856.7" "800.1" "1744.0" "" "" "" "" "" "" "" "" "" "" "787.7" "689.1" "716.4" "807.8" "709.2" "799.9" "656.0" "756.7" "715.9" "622.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9091705123101461009" "False" "High" "IsMasterProtein" "P99999" "Cytochrome c OS=Homo sapiens OX=9606 GN=CYCS PE=1 SV=2" "0.000" "False" "52.155" "71" "9" "28" "9" "105" "11.7" "9.57" "103.68" "9" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00034" "54205" "ENSG00000172115" "CYCS" "A4D166; B2R4I1; hsa:54205; P00001; P99999; Q6NUR2; Q6NX69; Q96BV4" "miRNA regulation of DNA damage response; Apoptosis modulation and signaling; Alzheimer's disease and miRNA effects; AGE/RAGE pathway; Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; VEGFA-VEGFR2 signaling; Oxidative damage response; NO/cGMP/PKG mediated neuroprotection; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Pleural mesothelioma; Complement system in neuronal development and plasticity; Alzheimer's disease; DNA damage response" "Respiratory electron transport; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria; Pyroptosis" "36" "0" "0.951" "1.002" "1.066" "0.955" "1.048" "1.006" "1.040" "0.928" "0.821" "2512.4" "2390.2" "2516.7" "2679.2" "2398.5" "2632.8" "2528.2" "2613.7" "2331.0" "2063.4" "" "" "" "" "" "" "" "" "" "" "2258.9" "1934.1" "2276.4" "2615.3" "1979.3" "2632.8" "1893.1" "2308.6" "2085.7" "736.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765155610572928931" "False" "High" "IsMasterProtein" "Q8IZ73" "Pseudouridylate synthase RPUSD2 OS=Homo sapiens OX=9606 GN=RPUSD2 PE=1 SV=2" "0.000" "False" "52.132" "30" "11" "13" "11" "545" "61.3" "7.17" "54.91" "11" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00849" "27079" "ENSG00000166133" "RPUSD2" "B4DDD1; hsa:27079; Q7L989; Q8IZ73; Q92939; Q96IA7; Q96N50" "" "" "0" "0" "1.030" "1.013" "1.052" "1.121" "0.973" "1.025" "1.012" "1.104" "0.964" "1089.1" "1122.0" "1102.9" "1145.9" "1221.3" "1059.4" "1116.8" "1102.4" "1202.5" "1049.6" "" "" "" "" "" "" "" "" "" "" "979.2" "907.9" "997.7" "1118.5" "1007.9" "1059.4" "836.2" "973.7" "1076.0" "374.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-577333653668623519" "False" "High" "IsMasterProtein" "Q9HAD4" "WD repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=WDR41 PE=1 SV=3" "0.000" "False" "52.093" "36" "14" "17" "14" "459" "51.7" "5.44" "59.41" "14" "other metabolic processes;other biological processes" "other cell component" "" "Pf00400" "55255" "ENSG00000164253" "WDR41" "B4DT55; hsa:55255; Q7Z792; Q8IWG3; Q8IXA9; Q8NDA7; Q9HAD4; Q9NV62" "" "" "0" "0" "1.139" "1.005" "1.015" "1.103" "1.018" "1.017" "1.048" "1.145" "0.885" "878.8" "1001.2" "883.1" "892.3" "969.3" "894.7" "893.9" "920.9" "1006.0" "777.8" "" "" "" "" "" "" "" "" "" "" "790.1" "810.1" "798.8" "871.1" "799.9" "894.7" "669.3" "813.4" "900.2" "277.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962760823323839829" "False" "High" "IsMasterProtein" "O43681" "ATPase GET3 OS=Homo sapiens OX=9606 GN=GET3 PE=1 SV=2" "0.000" "False" "52.055" "45" "12" "24" "12" "348" "38.8" "4.91" "89.38" "12" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf02374" "439" "ENSG00000198356" "GET3" "A6NHP8; A8K740; hsa:439; O43681; Q53FC6; Q92849" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.034" "1.007" "0.997" "1.053" "0.988" "1.013" "0.987" "1.038" "0.873" "1497.8" "1549.0" "1508.5" "1492.9" "1577.1" "1480.4" "1516.5" "1478.2" "1554.0" "1307.4" "" "" "" "" "" "" "" "" "" "" "1346.6" "1253.4" "1364.5" "1457.3" "1301.4" "1480.4" "1135.5" "1305.6" "1390.5" "466.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6667619497174905717" "False" "High" "IsMasterProtein" "Q96MW1" "Coiled-coil domain-containing protein 43 OS=Homo sapiens OX=9606 GN=CCDC43 PE=1 SV=2" "0.000" "False" "52.030" "34" "6" "19" "6" "224" "25.2" "4.92" "76.68" "6" "" "cytosol" "" "" "124808" "ENSG00000180329" "CCDC43" "C9JVK9; hsa:124808; Q96MW1" "" "" "0" "0" "0.913" "0.957" "0.948" "0.906" "0.950" "0.930" "0.977" "0.962" "0.710" "1183.7" "1080.8" "1132.6" "1122.2" "1072.9" "1125.0" "1100.3" "1156.8" "1138.6" "840.5" "" "" "" "" "" "" "" "" "" "" "1064.3" "874.6" "1024.5" "1095.4" "885.4" "1125.0" "823.9" "1021.7" "1018.8" "300.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400843138587659979" "False" "High" "IsMasterProtein" "P98175" "RNA-binding protein 10 OS=Homo sapiens OX=9606 GN=RBM10 PE=1 SV=3" "0.000" "False" "52.012" "16" "13" "17" "12" "930" "103.5" "5.97" "63.88" "13" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "8241" "ENSG00000182872" "RBM10" "A0A0A0MR66; C4AM81; hsa:8241; P98175; Q14136; Q5JRR2; Q9BTE4; Q9BTX0; Q9NTB1" "" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "1.005" "1.020" "0.949" "1.104" "1.099" "1.041" "1.032" "1.025" "0.914" "1349.1" "1356.5" "1375.8" "1280.6" "1490.0" "1483.2" "1404.3" "1391.7" "1382.4" "1232.5" "" "" "" "" "" "" "" "" "" "" "1212.9" "1097.6" "1244.4" "1250.1" "1229.6" "1483.2" "1051.5" "1229.2" "1237.0" "440.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5953183427719841951" "False" "High" "IsMasterProtein" "P18615" "Negative elongation factor E OS=Homo sapiens OX=9606 GN=NELFE PE=1 SV=3" "0.000" "False" "51.976" "41" "12" "16" "12" "380" "43.2" "9.33" "66.90" "12" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7936" "ENSG00000204356; ENSG00000206268; ENSG00000206357; ENSG00000229363; ENSG00000231044; ENSG00000233801" "NELFE" "A2BE08; B4DUN1; B4DYX9; hsa:7936; P18615; Q5JP74; Q5JP75; Q96F56; Q9NPK2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "0.971" "0.982" "0.926" "1.054" "0.990" "0.925" "1.031" "0.987" "0.973" "1934.4" "1878.4" "1898.8" "1792.0" "2038.1" "1914.9" "1789.8" "1994.3" "1908.9" "1883.1" "" "" "" "" "" "" "" "" "" "" "1739.2" "1519.9" "1717.6" "1749.3" "1681.9" "1914.9" "1340.2" "1761.5" "1708.1" "672.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5667017434232915728" "False" "High" "IsMasterProtein" "Q9Y618" "Nuclear receptor corepressor 2 OS=Homo sapiens OX=9606 GN=NCOR2 PE=1 SV=3" "0.000" "False" "51.968" "6" "14" "18" "13" "2514" "273.5" "7.59" "60.14" "14" "transport;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00249, Pf15784" "9612" "ENSG00000196498" "NCOR2" "hsa:9612; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; Q9Y618" "Androgen receptor signaling pathway; Adipogenesis; Aryl hydrocarbon receptor pathway; Notch signaling; Rett syndrome; Notch signaling pathway" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of transcription cofactors; HDACs deacetylate histones; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "23" "0" "0.976" "0.920" "0.964" "1.052" "0.979" "1.040" "1.015" "1.011" "1.163" "672.5" "656.1" "618.6" "648.5" "707.2" "658.2" "699.4" "682.4" "679.6" "781.8" "" "" "" "" "" "" "" "" "" "" "604.6" "530.9" "559.5" "633.0" "583.6" "658.2" "523.7" "602.8" "608.1" "279.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2034922387344060046" "False" "High" "IsMasterProtein" "P12955" "Xaa-Pro dipeptidase OS=Homo sapiens OX=9606 GN=PEPD PE=1 SV=3" "0.000" "False" "51.951" "29" "12" "21" "12" "493" "54.5" "6.00" "78.96" "12" "protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf00557, Pf05195" "5184" "ENSG00000124299" "PEPD" "A8K3Z1; A8K416; A8K696; A8MX47; B4DDB7; B4DGJ1; E9PCE8; hsa:5184; P12955; Q8TBN9; Q9BT75" "" "" "0" "0" "1.004" "1.059" "1.073" "1.177" "1.062" "1.107" "0.988" "1.089" "0.970" "1476.2" "1481.6" "1562.8" "1583.7" "1737.5" "1567.3" "1634.8" "1458.5" "1607.7" "1431.5" "" "" "" "" "" "" "" "" "" "" "1327.2" "1198.9" "1413.6" "1546.0" "1433.9" "1567.3" "1224.1" "1288.2" "1438.6" "511.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8263203131680576726" "False" "High" "IsMasterProtein" "Cont_P13717" "Nuclease OS=Serratia marcescens OX=615 GN=nucA PE=1 SV=2" "0.000" "True" "51.942" "45" "8" "15" "8" "266" "28.9" "7.42" "69.46" "8" "" "non-structural extracellular" "nucleic acid binding activity;other molecular function" "Pf01223" "66715254" "" "nucA" "A0A2V4G0H5; A0A5C7C9X8; A0A656VIL2; P13717" "" "" "0" "0" "0.918" "0.921" "0.992" "0.950" "0.883" "0.974" "0.945" "0.920" "0.808" "1530.0" "1404.7" "1408.5" "1517.2" "1453.8" "1350.9" "1490.2" "1446.5" "1407.0" "1236.3" "" "" "" "" "" "" "" "" "" "" "1375.6" "1136.6" "1274.1" "1481.0" "1199.7" "1350.9" "1115.8" "1277.6" "1259.0" "441.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4596787228496680093" "False" "High" "IsMasterProtein" "Q9BV86" "N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Homo sapiens OX=9606 GN=NTMT1 PE=1 SV=3" "0.000" "False" "51.919" "35" "6" "14" "6" "223" "25.4" "5.52" "72.13" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05891" "28989" "ENSG00000148335" "NTMT1" "A8K4J2; A8K8G7; hsa:28989; Q5SZB9; Q9BV86; Q9UI28" "" "" "0" "0" "1.066" "1.071" "1.009" "1.082" "1.089" "1.047" "0.989" "1.095" "0.908" "1076.9" "1147.7" "1153.5" "1087.0" "1165.4" "1173.0" "1127.3" "1064.9" "1179.5" "977.6" "" "" "" "" "" "" "" "" "" "" "968.2" "928.7" "1043.4" "1061.1" "961.7" "1173.0" "844.1" "940.6" "1055.4" "349.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2491250249564736583" "False" "High" "IsMasterProtein" "P49902" "Cytosolic purine 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C2 PE=1 SV=1" "0.000" "False" "51.917" "22" "12" "18" "12" "561" "64.9" "6.14" "57.99" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf05761" "22978" "ENSG00000076685" "NT5C2" "B7Z382; D3DR91; hsa:22978; P49902; Q5JUV5" "" "Purine catabolism; Ribavirin ADME; Abacavir metabolism" "3" "0" "0.978" "1.022" "0.937" "0.969" "0.911" "0.944" "0.967" "0.983" "0.768" "2073.7" "2028.9" "2119.5" "1942.9" "2009.1" "1890.0" "1956.8" "2004.6" "2037.6" "1593.1" "" "" "" "" "" "" "" "" "" "" "1864.4" "1641.7" "1917.2" "1896.5" "1657.9" "1890.0" "1465.2" "1770.6" "1823.2" "568.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6809936595777039335" "False" "High" "IsMasterProtein" "Q69YN4" "Protein virilizer homolog OS=Homo sapiens OX=9606 GN=VIRMA PE=1 SV=2" "0.000" "False" "51.903" "10" "18" "21" "18" "1812" "201.9" "5.01" "58.68" "18" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15912" "25962" "ENSG00000164944" "VIRMA" "hsa:25962; Q2M1N0; Q69YN4; Q6AHX9; Q6NT78; Q7Z6C7; Q8IXH4; Q9BTH4; Q9H9C9; Q9NWR3; Q9P2B8; Q9UFW1" "" "" "0" "0" "1.017" "1.048" "0.956" "0.982" "1.100" "0.972" "0.907" "1.020" "0.899" "1099.7" "1118.4" "1152.9" "1051.5" "1079.8" "1209.9" "1069.2" "997.6" "1121.3" "988.6" "" "" "" "" "" "" "" "" "" "" "988.7" "905.0" "1042.8" "1026.4" "891.0" "1209.9" "800.6" "881.1" "1003.3" "352.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796563562417500540" "False" "High" "IsMasterProtein" "P51532" "Transcription activator BRG1 OS=Homo sapiens OX=9606 GN=SMARCA4 PE=1 SV=2" "0.000" "False" "51.893" "8" "12" "15" "12" "1647" "184.5" "7.88" "56.64" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00439, Pf07529, Pf07533, Pf08880, Pf14619" "6597" "ENSG00000127616" "SMARCA4" "B1A8Z4; B1A8Z5; B1A8Z6; B1A8Z7; E9PBR8; hsa:6597; O95052; P51532; Q9HBD3" "Androgen receptor network in prostate cancer; Pre-implantation embryo; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Tumor suppressor activity of SMARCB1; Rett syndrome; Thermogenesis; Kleefstra syndrome" "Formation of the beta-catenin:TCF transactivating complex; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Interleukin-7 signaling; RMTs methylate histone arginines; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "13" "0" "0.941" "0.776" "0.901" "0.912" "0.842" "1.014" "0.718" "0.745" "6.407" "780.9" "735.1" "606.0" "703.4" "712.0" "657.3" "792.0" "561.1" "581.7" "5003.3" "" "" "" "" "" "" "" "" "" "" "702.1" "594.8" "548.2" "686.6" "587.5" "657.3" "593.0" "495.6" "520.5" "1786.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6086246065885053041" "False" "High" "IsMasterProtein" "Cont_P02533" "Keratin, type I cytoskeletal 14 OS=Homo sapiens OX=9606 GN=KRT14 PE=1 SV=4" "0.000" "True" "51.869" "30" "14" "23" "5" "472" "51.5" "5.16" "77.21" "14" "cell organization and biogenesis;other biological processes" "plasma membrane;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00038" "3861" "ENSG00000186847" "KRT14" "hsa:3861; P02533; Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4" "Corticotropin-releasing hormone signaling pathway" "Formation of the cornified envelope; Type I hemidesmosome assembly" "4" "0" "0.373" "0.343" "0.418" "0.347" "1.120" "0.857" "0.451" "0.369" "0.541" "844.3" "315.1" "290.0" "353.1" "293.0" "945.6" "723.4" "381.0" "311.9" "456.9" "" "" "" "" "" "" "" "" "" "" "759.1" "255.0" "262.3" "344.7" "241.7" "945.6" "541.7" "336.5" "279.0" "163.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6970631393786121187" "False" "High" "IsMasterProtein" "Q8WU79" "Stromal membrane-associated protein 2 OS=Homo sapiens OX=9606 GN=SMAP2 PE=1 SV=1" "0.000" "False" "51.817" "26" "12" "19" "11" "429" "46.8" "8.87" "72.22" "12" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "64744" "ENSG00000084070" "SMAP2" "B2R7T1; B7Z5B5; B7Z8V2; D3DPV2; hsa:64744; Q5QPL2; Q8WU79; Q96C93; Q9NST2; Q9UJL8" "" "" "0" "1" "0.994" "0.966" "0.993" "1.020" "0.965" "1.003" "1.015" "0.959" "1.213" "1551.2" "1541.4" "1498.9" "1540.9" "1581.5" "1496.7" "1556.0" "1574.4" "1487.5" "1882.1" "" "" "" "" "" "" "" "" "" "" "1394.7" "1247.3" "1355.8" "1504.1" "1305.1" "1496.7" "1165.1" "1390.6" "1331.0" "671.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3264594850844257822" "False" "High" "IsMasterProtein" "P50440" "Glycine amidinotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=GATM PE=1 SV=1" "0.000" "False" "51.796" "37" "13" "17" "13" "423" "48.4" "8.05" "55.68" "13" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "2628" "ENSG00000171766" "GATM" "B4DH99; B4DPI3; hsa:2628; P50440; Q53EQ4" "Creatine pathway" "Creatine metabolism" "2" "0" "1.028" "1.049" "0.989" "1.020" "1.014" "0.997" "1.032" "1.077" "0.899" "940.9" "967.4" "986.8" "930.4" "959.7" "954.0" "938.1" "971.1" "1013.8" "845.7" "" "" "" "" "" "" "" "" "" "" "846.0" "782.8" "892.6" "908.2" "792.0" "954.0" "702.4" "857.7" "907.2" "301.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5006297447401564784" "False" "High" "IsMasterProtein" "Q96B23" "Protein ARK2N OS=Homo sapiens OX=9606 GN=ARK2N PE=1 SV=3" "0.000" "False" "51.783" "19" "7" "15" "7" "404" "43.4" "4.88" "59.91" "7" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15303" "147339" "ENSG00000152242" "ARK2N" "A8K123; A8KAB6; hsa:147339; Q5BIX2; Q5XG78; Q6N058; Q86TB5; Q8TCQ5; Q96B23" "" "" "0" "0" "0.976" "0.970" "1.041" "1.041" "0.976" "0.931" "1.023" "1.002" "0.850" "1278.9" "1247.9" "1240.3" "1331.2" "1331.2" "1248.3" "1190.1" "1308.7" "1281.9" "1087.0" "" "" "" "" "" "" "" "" "" "" "1149.8" "1009.8" "1121.9" "1299.5" "1098.6" "1248.3" "891.1" "1155.9" "1147.0" "388.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5955155913055998566" "False" "High" "IsMasterProtein" "P28062" "Proteasome subunit beta type-8 OS=Homo sapiens OX=9606 GN=PSMB8 PE=1 SV=3" "0.000" "False" "51.774" "34" "8" "23" "8" "276" "30.3" "7.43" "80.51" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5696" "ENSG00000204264; ENSG00000206298; ENSG00000226201; ENSG00000230034; ENSG00000230669; ENSG00000231631; ENSG00000235715; ENSG00000236443" "PSMB8" "B0UZC0; hsa:5696; P28062; Q29824; Q5JNW6; Q5QNR8; Q96J48" "Proteasome degradation; Immune response to tuberculosis" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Interferon alpha/beta signaling" "62" "0" "1.013" "0.990" "1.025" "1.040" "0.958" "1.073" "1.026" "1.016" "0.874" "1747.8" "1770.3" "1730.1" "1791.7" "1817.4" "1674.8" "1876.2" "1792.9" "1775.0" "1527.7" "" "" "" "" "" "" "" "" "" "" "1571.4" "1432.5" "1565.0" "1749.0" "1499.8" "1674.8" "1404.9" "1583.6" "1588.3" "545.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2329486021897558917" "False" "High" "IsMasterProtein" "P78347" "General transcription factor II-I OS=Homo sapiens OX=9606 GN=GTF2I PE=1 SV=2" "0.000" "False" "51.754" "15" "15" "19" "15" "998" "112.3" "6.39" "68.38" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02946" "2969" "ENSG00000263001" "GTF2I" "hsa:2969; O14743; O15359; O43546; O43588; O43589; P78347; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "" "3" "0" "1.080" "0.976" "1.015" "1.048" "1.030" "1.085" "0.798" "1.014" "13.812" "1178.1" "1272.7" "1149.4" "1195.5" "1234.1" "1213.7" "1278.0" "940.4" "1195.2" "16272.2" "" "" "" "" "" "" "" "" "" "" "1059.3" "1029.8" "1039.7" "1167.0" "1018.4" "1213.7" "957.0" "830.6" "1069.4" "5808.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7727744455345483682" "False" "High" "IsMasterProtein" "Q13868" "Exosome complex component RRP4 OS=Homo sapiens OX=9606 GN=EXOSC2 PE=1 SV=2" "0.000" "False" "51.751" "45" "10" "21" "10" "293" "32.8" "7.50" "76.99" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf14382, Pf15985, Pf21266" "23404" "ENSG00000130713" "EXOSC2" "A3KFL3; A3KFL4; B4DKK6; hsa:23404; Q13868; Q9NUY4" "Ciliary landscape" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "0.985" "0.988" "0.939" "1.019" "0.985" "1.030" "0.968" "1.018" "0.608" "1385.6" "1364.8" "1368.5" "1301.6" "1412.0" "1365.2" "1427.8" "1341.8" "1411.0" "842.4" "" "" "" "" "" "" "" "" "" "" "1245.8" "1104.3" "1237.9" "1270.5" "1165.2" "1365.2" "1069.1" "1185.1" "1262.5" "300.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5783897718523636057" "False" "High" "IsMasterProtein" "O95602" "DNA-directed RNA polymerase I subunit RPA1 OS=Homo sapiens OX=9606 GN=POLR1A PE=1 SV=2" "0.000" "False" "51.717" "10" "16" "19" "16" "1720" "194.7" "7.03" "55.81" "16" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "25885" "ENSG00000068654" "POLR1A" "B7Z7T0; D6W5M0; hsa:25885; O95602; Q0VG05; Q9UEH0; Q9UFT9" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "0.990" "1.188" "0.995" "0.972" "1.148" "1.035" "0.947" "1.156" "2.625" "1312.9" "1299.8" "1559.4" "1306.8" "1276.8" "1507.4" "1358.4" "1243.7" "1517.2" "3446.3" "" "" "" "" "" "" "" "" "" "" "1180.4" "1051.7" "1410.5" "1275.7" "1053.6" "1507.4" "1017.2" "1098.5" "1357.6" "1230.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3544092344489090561" "False" "High" "IsMasterProtein" "Q8TB72" "Pumilio homolog 2 OS=Homo sapiens OX=9606 GN=PUM2 PE=1 SV=2" "0.000" "False" "51.714" "11" "12" "20" "8" "1066" "114.1" "7.08" "66.91" "12" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00806" "23369" "ENSG00000055917" "PUM2" "B3KSL0; B4E2B6; D6W527; hsa:23369; O00234; Q53TV7; Q8TB72; Q8WY43; Q9HAN2" "Male infertility" "Neddylation" "2" "0" "0.981" "0.950" "0.968" "1.009" "0.941" "1.029" "0.973" "0.943" "0.839" "1859.4" "1824.3" "1765.8" "1800.0" "1876.0" "1749.8" "1912.8" "1808.5" "1752.8" "1560.2" "" "" "" "" "" "" "" "" "" "" "1671.8" "1476.1" "1597.3" "1757.1" "1548.1" "1749.8" "1432.2" "1597.4" "1568.4" "557.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5459643991948160099" "False" "High" "IsMasterProtein" "Q9NWH9" "SAFB-like transcription modulator OS=Homo sapiens OX=9606 GN=SLTM PE=1 SV=2" "0.000" "False" "51.658" "17" "15" "19" "15" "1034" "117.1" "7.87" "69.74" "15" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf02037" "79811" "ENSG00000137776" "SLTM" "A8K5V8; B2RTX3; hsa:79811; Q2VPK7; Q52MB3; Q658J7; Q6ZNF2; Q86TK6; Q9H7C3; Q9H8U9; Q9NWH9" "" "" "0" "0" "1.032" "0.947" "0.933" "1.039" "1.051" "1.008" "1.000" "0.872" "0.831" "1110.3" "1145.4" "1051.4" "1035.6" "1153.4" "1167.1" "1118.7" "1110.6" "968.7" "922.4" "" "" "" "" "" "" "" "" "" "" "998.3" "926.8" "951.0" "1010.9" "951.8" "1167.1" "837.7" "980.9" "866.8" "329.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8293533738236197165" "False" "High" "IsMasterProtein" "O75347" "Tubulin-specific chaperone A OS=Homo sapiens OX=9606 GN=TBCA PE=1 SV=3" "0.000" "False" "51.633" "58" "10" "41" "10" "108" "12.8" "5.29" "130.68" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02970" "6902" "ENSG00000171530" "TBCA" "B4DT30; hsa:6902; O75347" "VEGFA-VEGFR2 signaling" "Post-chaperonin tubulin folding pathway" "2" "0" "0.947" "0.927" "0.937" "0.895" "0.902" "0.915" "0.987" "0.874" "0.720" "6207.9" "5881.5" "5756.5" "5817.9" "5557.0" "5601.7" "5677.7" "6126.7" "5425.9" "4467.2" "" "" "" "" "" "" "" "" "" "" "5581.5" "4759.1" "5206.9" "5679.0" "4585.7" "5601.7" "4251.3" "5411.5" "4855.0" "1594.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3384207672428186398" "False" "High" "IsMasterProtein" "Q8N335" "Glycerol-3-phosphate dehydrogenase 1-like protein OS=Homo sapiens OX=9606 GN=GPD1L PE=1 SV=1" "0.000" "False" "51.627" "37" "11" "27" "11" "351" "38.4" "7.02" "100.54" "11" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01210, Pf07479" "23171" "ENSG00000152642" "GPD1L" "A8K9U3; hsa:23171; Q14702; Q8N335; Q9BRM5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Synthesis of PA" "2" "0" "1.015" "0.996" "0.930" "1.000" "0.922" "0.979" "1.001" "0.964" "0.833" "2738.3" "2780.4" "2727.2" "2547.6" "2737.6" "2524.6" "2679.4" "2741.3" "2638.3" "2280.3" "" "" "" "" "" "" "" "" "" "" "2462.0" "2249.8" "2466.8" "2486.8" "2259.2" "2524.6" "2006.3" "2421.3" "2360.8" "814.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1824011876683044668" "False" "High" "IsMasterProtein" "Q9ULA0" "Aspartyl aminopeptidase OS=Homo sapiens OX=9606 GN=DNPEP PE=1 SV=2" "0.000" "False" "51.553" "26" "11" "15" "11" "485" "53.4" "7.58" "56.15" "11" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02127" "23549" "ENSG00000123992" "DNPEP" "hsa:23549; Q9BW44; Q9NUV5; Q9NV55; Q9ULA0" "Ciliary landscape" "" "1" "0" "1.019" "1.016" "0.948" "1.043" "0.996" "0.994" "1.012" "1.050" "0.790" "1319.8" "1345.3" "1341.2" "1251.6" "1376.0" "1314.7" "1311.3" "1335.3" "1385.8" "1043.1" "" "" "" "" "" "" "" "" "" "" "1186.6" "1088.6" "1213.2" "1221.8" "1135.5" "1314.7" "981.9" "1179.4" "1240.0" "372.4" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911764670660096816" "False" "High" "IsMasterProtein" "P08195" "Amino acid transporter heavy chain SLC3A2 OS=Homo sapiens OX=9606 GN=SLC3A2 PE=1 SV=3" "0.000" "False" "51.532" "24" "12" "15" "12" "630" "68.0" "5.01" "58.76" "12" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;nucleic acid binding activity;other molecular function" "Pf00128, Pf16028" "6520" "ENSG00000168003" "SLC3A2" "hsa:6520; J3KPF3; P08195; Q13543" "mRNA, protein, and metabolite inducation pathway by cyclosporin A; Ferroptosis; Proximal tubule transport; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane; Defective SLC7A7 causes lysinuric protein intolerance (LPI)" "8" "0" "0.874" "0.880" "0.957" "0.882" "0.847" "0.908" "0.963" "0.923" "0.617" "1435.0" "1254.2" "1263.2" "1374.1" "1266.2" "1216.2" "1302.6" "1381.3" "1324.8" "886.1" "" "" "" "" "" "" "" "" "" "" "1290.2" "1014.9" "1142.6" "1341.3" "1044.9" "1216.2" "975.4" "1220.1" "1185.5" "316.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2601253202356678168" "False" "High" "IsMasterProtein" "P31937" "3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBADH PE=1 SV=2" "0.000" "False" "51.516" "31" "7" "15" "7" "336" "35.3" "8.13" "69.33" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf03446, Pf14833" "11112" "ENSG00000106049" "HIBADH" "hsa:11112; P31937; Q546Z2; Q9UDN3" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.963" "0.970" "1.002" "1.056" "0.983" "1.036" "0.988" "0.999" "0.792" "1380.2" "1329.3" "1338.5" "1383.5" "1456.9" "1357.2" "1429.3" "1363.0" "1378.3" "1093.4" "" "" "" "" "" "" "" "" "" "" "1241.0" "1075.6" "1210.7" "1350.5" "1202.2" "1357.2" "1070.2" "1203.9" "1233.3" "390.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5490413544944086937" "False" "High" "IsMasterProtein" "Q9BPX5" "Actin-related protein 2/3 complex subunit 5-like protein OS=Homo sapiens OX=9606 GN=ARPC5L PE=1 SV=1" "0.000" "False" "51.507" "63" "8" "21" "8" "153" "16.9" "6.60" "89.96" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf04699" "81873" "ENSG00000136950" "ARPC5L" "hsa:81873; Q7Z523; Q9BPX5" "Pathogenic Escherichia coli infection; VEGFA-VEGFR2 signaling" "" "2" "0" "1.077" "1.002" "0.983" "1.076" "0.984" "1.016" "1.127" "1.039" "0.765" "1629.5" "1754.8" "1632.9" "1602.0" "1754.0" "1603.6" "1656.1" "1837.2" "1692.7" "1246.7" "" "" "" "" "" "" "" "" "" "" "1465.1" "1419.9" "1477.0" "1563.8" "1447.4" "1603.6" "1240.0" "1622.7" "1514.6" "445.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457086219515973345" "False" "High" "IsMasterProtein" "P61086" "Ubiquitin-conjugating enzyme E2 K OS=Homo sapiens OX=9606 GN=UBE2K PE=1 SV=3" "0.000" "False" "51.506" "48" "10" "23" "10" "200" "22.4" "5.44" "80.49" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179, Pf00627" "3093" "ENSG00000078140" "UBE2K" "A6NJC1; A8K5Y9; B2RDF8; C9JGP1; hsa:3093; O54806; P27924; P61086; Q16721; Q9CVV9; Q9Y2D3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Negative regulators of DDX58/IFIH1 signaling" "3" "0" "1.019" "1.042" "0.987" "1.050" "1.045" "1.002" "1.026" "1.041" "0.841" "1986.7" "2024.2" "2069.9" "1961.8" "2086.2" "2075.6" "1990.2" "2039.1" "2068.6" "1671.6" "" "" "" "" "" "" "" "" "" "" "1786.2" "1637.9" "1872.3" "1915.0" "1721.6" "2075.6" "1490.2" "1801.1" "1851.0" "596.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1948602544583202968" "False" "High" "IsMasterProtein" "Q13042" "Cell division cycle protein 16 homolog OS=Homo sapiens OX=9606 GN=CDC16 PE=1 SV=2" "0.000" "False" "51.488" "19" "11" "19" "11" "620" "71.6" "5.85" "67.27" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf12895, Pf13424" "8881" "ENSG00000130177" "CDC16" "A2A365; hsa:8881; Q13042; Q5T8C8; Q7Z651; Q96AE6; Q9Y564" "Cell cycle" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.031" "0.977" "0.909" "1.037" "0.995" "1.030" "0.944" "0.985" "0.934" "1278.8" "1318.9" "1249.4" "1162.0" "1326.6" "1271.9" "1317.6" "1207.6" "1259.9" "1194.8" "" "" "" "" "" "" "" "" "" "" "1149.8" "1067.2" "1130.1" "1134.2" "1094.7" "1271.9" "986.6" "1066.6" "1127.4" "426.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-366099160936262297" "False" "High" "IsMasterProtein" "Q9NQG5" "Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Homo sapiens OX=9606 GN=RPRD1B PE=1 SV=1" "0.000" "False" "51.455" "39" "11" "18" "10" "326" "36.9" "5.97" "73.13" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "58490" "ENSG00000101413" "RPRD1B" "hsa:58490; Q1WDE7; Q6PKF4; Q9NQG5" "Modulators of TCR signaling and T cell activation" "RNA polymerase II transcribes snRNA genes" "2" "1" "0.972" "1.009" "1.023" "1.008" "1.038" "0.993" "1.013" "0.994" "0.968" "1704.7" "1656.8" "1720.1" "1744.4" "1717.5" "1770.0" "1692.9" "1726.3" "1693.6" "1649.9" "" "" "" "" "" "" "" "" "" "" "1532.7" "1340.6" "1555.9" "1702.8" "1417.3" "1770.0" "1267.6" "1524.7" "1515.4" "589.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4476528208765438767" "False" "High" "IsMasterProtein" "Q9Y5S9" "RNA-binding protein 8A OS=Homo sapiens OX=9606 GN=RBM8A PE=1 SV=1" "0.000" "False" "51.436" "45" "7" "21" "7" "174" "19.9" "5.72" "100.81" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "9939" "ENSG00000265241" "RBM8A" "B3KQI9; hsa:9939; Q6FHD1; Q6IQ40; Q9GZX8; Q9NZI4; Q9Y5S9" "" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.930" "0.909" "0.955" "0.924" "0.884" "0.882" "0.979" "0.964" "0.807" "1566.1" "1456.4" "1423.6" "1495.9" "1447.4" "1383.9" "1381.3" "1533.0" "1509.3" "1264.3" "" "" "" "" "" "" "" "" "" "" "1408.1" "1178.5" "1287.7" "1460.2" "1194.4" "1383.9" "1034.3" "1354.0" "1350.5" "451.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1962544655148758053" "False" "High" "IsMasterProtein" "P35240" "Merlin OS=Homo sapiens OX=9606 GN=NF2 PE=1 SV=1" "0.000" "False" "51.429" "23" "13" "15" "13" "595" "69.6" "6.47" "60.08" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00373, Pf00769, Pf09379, Pf09380, Pf20492" "4771" "ENSG00000186575" "NF2" "hsa:4771; O95683; P35240; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3; Q9UNH4" "Ectoderm differentiation; Ectoderm differentiation; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; 3q29 copy number variation syndrome; Pleural mesothelioma" "Regulation of actin dynamics for phagocytic cup formation; RHO GTPases activate PAKs" "10" "0" "1.016" "0.978" "0.952" "1.016" "0.950" "1.052" "0.979" "0.939" "0.838" "832.6" "846.2" "814.7" "792.7" "846.2" "791.0" "876.1" "815.2" "782.1" "697.6" "" "" "" "" "" "" "" "" "" "" "748.6" "684.7" "736.9" "773.8" "698.3" "791.0" "656.0" "720.0" "699.8" "249.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7261913870359179685" "False" "High" "IsMasterProtein" "O75165" "DnaJ homolog subfamily C member 13 OS=Homo sapiens OX=9606 GN=DNAJC13 PE=1 SV=5" "0.000" "False" "51.380" "7" "17" "19" "17" "2243" "254.3" "6.74" "55.78" "17" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf00226, Pf14237, Pf19432" "23317" "ENSG00000138246" "DNAJC13" "hsa:23317; O75165; Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9" "" "Neutrophil degranulation" "1" "0" "1.050" "0.956" "0.953" "0.988" "0.898" "1.022" "1.029" "1.036" "0.847" "1238.1" "1299.8" "1183.5" "1179.9" "1222.9" "1111.4" "1265.2" "1273.8" "1282.1" "1048.7" "" "" "" "" "" "" "" "" "" "" "1113.2" "1051.7" "1070.6" "1151.8" "1009.2" "1111.4" "947.4" "1125.1" "1147.2" "374.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470194220236547975" "False" "High" "IsMasterProtein" "Q5TBB1" "Ribonuclease H2 subunit B OS=Homo sapiens OX=9606 GN=RNASEH2B PE=1 SV=1" "0.000" "False" "51.326" "36" "12" "19" "12" "312" "35.1" "9.13" "71.00" "12" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf09468, Pf17745" "79621" "ENSG00000136104" "RNASEH2B" "G3XAJ1; hsa:79621; Q05DR2; Q5TBB1; Q6PK48; Q9HAF7" "" "" "0" "0" "0.917" "0.908" "1.000" "0.913" "0.905" "0.986" "0.945" "0.899" "1.254" "2115.3" "1939.5" "1920.9" "2115.9" "1932.0" "1914.6" "2086.7" "1999.1" "1901.5" "2652.6" "" "" "" "" "" "" "" "" "" "" "1901.8" "1569.3" "1737.5" "2065.4" "1594.3" "1914.6" "1562.5" "1765.7" "1701.5" "946.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7235232019180232965" "False" "High" "IsMasterProtein" "A0A3B3IRV3" "Malignant T-cell-amplified sequence 2 OS=Homo sapiens OX=9606 GN=MCTS2 PE=1 SV=1" "0.000" "False" "51.296" "46" "6" "18" "1" "181" "20.3" "9.01" "71.01" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01472, Pf17832" "" "ENSG00000101898" "MCTS2" "A0A3B3IRV3" "" "" "0" "0" "1.009" "0.855" "0.977" "1.033" "0.981" "1.116" "0.981" "0.867" "0.714" "62.8" "63.3" "53.7" "61.3" "64.8" "61.5" "70.0" "61.5" "54.4" "44.8" "" "" "" "" "" "" "" "" "" "" "56.4" "51.2" "48.5" "59.9" "53.5" "61.5" "52.4" "54.3" "48.7" "16.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7497019614434814723" "False" "High" "IsMasterProtein" "Q9NQH7" "Xaa-Pro aminopeptidase 3 OS=Homo sapiens OX=9606 GN=XPNPEP3 PE=1 SV=1" "0.000" "False" "51.293" "36" "14" "35" "13" "507" "57.0" "6.83" "103.46" "14" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00557, Pf05195" "63929" "ENSG00000196236" "XPNPEP3" "B2R9G1; B7Z790; B7Z7B2; hsa:63929; Q6I9V9; Q8NDA6; Q9BV27; Q9BVH0; Q9NQH7" "Ciliary landscape; Ciliopathies" "" "2" "0" "1.043" "1.020" "1.038" "1.070" "1.039" "0.983" "1.037" "1.050" "0.942" "1234.4" "1287.9" "1259.6" "1280.9" "1320.8" "1282.4" "1213.8" "1280.2" "1296.0" "1162.6" "" "" "" "" "" "" "" "" "" "" "1109.9" "1042.1" "1139.3" "1250.4" "1089.9" "1282.4" "908.9" "1130.8" "1159.6" "415.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3338411764392514561" "False" "High" "IsMasterProtein" "P45954" "Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACADSB PE=1 SV=1" "0.000" "False" "51.179" "30" "9" "14" "9" "432" "47.5" "6.99" "61.99" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "36" "ENSG00000196177" "ACADSB" "B4DQ51; hsa:36; P45954; Q5SQN6; Q96CX7" "Valproic acid pathway" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "3" "0" "0.989" "1.009" "1.002" "0.995" "0.982" "0.995" "1.026" "1.056" "0.853" "1871.5" "1850.2" "1888.5" "1874.8" "1861.7" "1838.1" "1861.4" "1920.5" "1975.7" "1596.0" "" "" "" "" "" "" "" "" "" "" "1682.6" "1497.1" "1708.2" "1830.0" "1536.3" "1838.1" "1393.8" "1696.3" "1767.8" "569.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5309458315612800198" "False" "High" "IsMasterProtein" "O00178" "GTP-binding protein 1 OS=Homo sapiens OX=9606 GN=GTPBP1 PE=1 SV=3" "0.000" "False" "51.023" "29" "14" "17" "14" "669" "72.4" "8.34" "65.40" "14" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144" "9567" "ENSG00000100226" "GTPBP1" "hsa:9567; O00178; Q6IC67" "" "" "0" "0" "0.996" "0.998" "0.941" "1.039" "1.024" "1.097" "0.978" "0.948" "0.890" "1042.3" "1038.1" "1040.7" "980.7" "1083.1" "1067.5" "1143.3" "1019.3" "988.4" "927.9" "" "" "" "" "" "" "" "" "" "" "937.1" "840.0" "941.3" "957.3" "893.8" "1067.5" "856.1" "900.3" "884.4" "331.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9207268972416967358" "False" "High" "IsMasterProtein" "O15066" "Kinesin-like protein KIF3B OS=Homo sapiens OX=9606 GN=KIF3B PE=1 SV=1" "0.000" "False" "50.967" "23" "16" "20" "15" "747" "85.1" "7.69" "58.95" "16" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "9371" "ENSG00000101350" "KIF3B" "B2RMP4; B4DSR5; E1P5M5; hsa:9371; O15066" "" "Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Kinesins" "5" "0" "1.017" "1.011" "1.086" "1.013" "1.047" "1.068" "1.026" "1.059" "1.133" "936.4" "952.0" "946.5" "1017.2" "948.8" "980.5" "999.9" "960.3" "991.7" "1061.0" "" "" "" "" "" "" "" "" "" "" "841.9" "770.4" "856.2" "992.9" "783.0" "980.5" "748.7" "848.2" "887.3" "378.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216911938682189755" "False" "High" "IsMasterProtein" "Q27J81" "Inverted formin-2 OS=Homo sapiens OX=9606 GN=INF2 PE=1 SV=2" "0.000" "False" "50.932" "12" "12" "17" "12" "1249" "135.5" "5.38" "67.96" "12" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf02205, Pf06367, Pf06371" "64423" "ENSG00000203485" "INF2" "hsa:64423; Q27J81; Q27J83; Q69YL8; Q6P1X7; Q6PK22; Q86TR7; Q9BRM1; Q9H6N1" "Primary focal segmental glomerulosclerosis (FSGS); Nephrotic syndrome" "" "2" "0" "1.062" "1.023" "0.992" "1.106" "1.091" "1.110" "1.025" "1.072" "1.444" "898.9" "954.3" "919.6" "891.4" "994.6" "980.7" "997.6" "921.4" "963.5" "1298.3" "" "" "" "" "" "" "" "" "" "" "808.2" "772.2" "831.8" "870.1" "820.8" "980.7" "747.0" "813.8" "862.2" "463.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2449426517635308859" "False" "High" "IsMasterProtein" "Q9H6F5" "Coiled-coil domain-containing protein 86 OS=Homo sapiens OX=9606 GN=CCDC86 PE=1 SV=1" "0.000" "False" "50.837" "40" "15" "21" "15" "360" "40.2" "10.33" "71.92" "15" "" "nucleus;other cell component" "" "Pf03879" "79080" "ENSG00000110104" "CCDC86" "B4DY99; hsa:79080; Q9H6F5" "" "" "0" "0" "1.078" "1.102" "1.001" "0.966" "1.327" "0.994" "1.129" "1.006" "0.896" "1180.4" "1272.4" "1300.6" "1181.8" "1140.8" "1566.8" "1173.1" "1333.0" "1187.6" "1057.1" "" "" "" "" "" "" "" "" "" "" "1061.3" "1029.6" "1176.4" "1153.6" "941.4" "1566.8" "878.4" "1177.4" "1062.6" "377.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4307491490075501206" "False" "High" "IsMasterProtein" "P32322" "Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PYCR1 PE=1 SV=2" "0.000" "False" "50.810" "37" "9" "16" "8" "319" "33.3" "7.61" "69.35" "9" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf03807, Pf14748" "5831" "ENSG00000183010" "PYCR1" "A6NFM2; B4DMU0; hsa:5831; P32322; Q6FHI4; Q96DI6; Q9HBQ4" "Amino acid metabolism; Metabolic reprogramming in colon cancer" "Glutamate and glutamine metabolism" "3" "0" "0.967" "1.042" "1.003" "0.945" "1.000" "1.005" "1.021" "1.026" "0.769" "856.7" "828.3" "892.7" "859.1" "809.9" "857.1" "860.7" "874.3" "878.9" "658.5" "" "" "" "" "" "" "" "" "" "" "770.3" "670.3" "807.5" "838.6" "668.4" "857.1" "644.5" "772.2" "786.5" "235.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8827666052570193854" "False" "High" "IsMasterProtein" "Q15056" "Eukaryotic translation initiation factor 4H OS=Homo sapiens OX=9606 GN=EIF4H PE=1 SV=5" "0.000" "False" "50.797" "56" "12" "33" "12" "248" "27.4" "7.23" "125.64" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf00076" "7458" "ENSG00000106682" "EIF4H" "A8K3R1; D3DXF6; D3DXF8; hsa:7458; Q15056" "Translation factors; 7q11.23 copy number variation syndrome" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Ribosomal scanning and start codon recognition" "7" "0" "0.995" "0.955" "0.987" "0.928" "1.072" "0.965" "1.051" "0.933" "0.848" "2786.3" "2771.6" "2661.4" "2748.9" "2584.9" "2986.6" "2689.0" "2927.5" "2600.4" "2361.5" "" "" "" "" "" "" "" "" "" "" "2505.2" "2242.6" "2407.3" "2683.3" "2133.1" "2986.6" "2013.4" "2585.7" "2326.9" "843.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2163956888383823018" "False" "High" "IsMasterProtein" "Q96A65" "Exocyst complex component 4 OS=Homo sapiens OX=9606 GN=EXOC4 PE=1 SV=1" "0.000" "False" "50.753" "14" "12" "18" "12" "974" "110.4" "6.49" "63.33" "12" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04048, Pf20652" "60412" "ENSG00000131558" "EXOC4" "E9PED2; hsa:60412; Q541U8; Q96A65; Q9C0G4; Q9H9K0; Q9P102" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.037" "1.014" "0.976" "1.013" "0.999" "1.074" "0.976" "0.981" "2.367" "1085.9" "1126.5" "1101.3" "1059.6" "1100.5" "1084.3" "1166.1" "1060.2" "1065.4" "2570.7" "" "" "" "" "" "" "" "" "" "" "976.4" "911.5" "996.1" "1034.3" "908.2" "1084.3" "873.2" "936.5" "953.3" "917.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595092831186639682" "False" "High" "IsMasterProtein" "Q99961" "Endophilin-A2 OS=Homo sapiens OX=9606 GN=SH3GL1 PE=1 SV=1" "0.000" "False" "50.699" "30" "11" "17" "11" "368" "41.5" "5.43" "55.48" "11" "cell organization and biogenesis;transport;developmental processes;signal transduction" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf03114" "6455" "ENSG00000141985" "SH3GL1" "B4DRA1; E7EVZ4; hsa:6455; M0QZV5; Q99668; Q99961" "Fragile X syndrome" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell" "6" "0" "0.978" "1.027" "1.078" "1.031" "1.007" "1.073" "1.009" "1.034" "1.555" "1473.6" "1441.2" "1513.8" "1587.8" "1519.7" "1484.2" "1581.9" "1487.1" "1523.2" "2291.8" "" "" "" "" "" "" "" "" "" "" "1324.9" "1166.2" "1369.3" "1549.9" "1254.1" "1484.2" "1184.5" "1313.5" "1362.9" "818.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318152306764108447" "False" "High" "IsMasterProtein" "O60563" "Cyclin-T1 OS=Homo sapiens OX=9606 GN=CCNT1 PE=1 SV=1" "0.000" "False" "50.698" "17" "11" "16" "11" "726" "80.6" "8.78" "65.83" "11" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00134, Pf21797" "904" "ENSG00000129315" "CCNT1" "A9XU13; E7EX76; hsa:904; O60563; O60581" "Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interactions of Tat with host cellular proteins" "17" "0" "1.027" "1.107" "0.997" "1.008" "1.183" "1.026" "0.975" "1.055" "1.069" "2024.7" "2080.2" "2241.4" "2019.2" "2040.2" "2395.5" "2077.6" "1974.7" "2137.0" "2165.4" "" "" "" "" "" "" "" "" "" "" "1820.4" "1683.2" "2027.4" "1971.0" "1683.6" "2395.5" "1555.6" "1744.2" "1912.1" "773.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765443992663171126" "False" "High" "IsMasterProtein" "Q86UE8" "Serine/threonine-protein kinase tousled-like 2 OS=Homo sapiens OX=9606 GN=TLK2 PE=1 SV=2" "0.000" "False" "50.688" "24" "18" "20" "10" "772" "87.6" "8.41" "73.38" "18" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "11011" "ENSG00000146872" "TLK2" "D3DU07; hsa:11011; Q86UE8; Q9UKI7; Q9Y4F7" "miRNA regulation of DNA damage response; DNA damage response" "" "2" "6" "1.004" "0.952" "0.941" "0.987" "0.948" "1.017" "0.990" "0.953" "0.841" "2090.1" "2098.0" "1990.2" "1966.5" "2063.4" "1981.8" "2124.8" "2068.9" "1991.5" "1757.6" "" "" "" "" "" "" "" "" "" "" "1879.2" "1697.7" "1800.2" "1919.6" "1702.8" "1981.8" "1591.0" "1827.4" "1782.0" "627.4" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5376062369618088086" "False" "High" "IsMasterProtein" "P01834" "Immunoglobulin kappa constant OS=Homo sapiens OX=9606 GN=IGKC PE=1 SV=2" "0.000" "False" "50.602" "86" "6" "35" "6" "107" "11.8" "6.52" "163.07" "6" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf07654" "" "" "IGKC" "A0A075B6H6; A0A087X130; P01834" "" "Initial triggering of complement; Classical antibody-mediated complement activation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Scavenging of heme from plasma; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCERI mediated NF-kB activation; CD22 mediated BCR regulation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "19" "0" "0.960" "0.917" "1.145" "1.073" "0.917" "0.965" "1.082" "1.009" "0.807" "2075.4" "1992.4" "1903.5" "2375.7" "2226.0" "1902.9" "2001.8" "2244.7" "2094.1" "1673.8" "" "" "" "" "" "" "" "" "" "" "1865.9" "1612.2" "1721.8" "2319.0" "1836.9" "1902.9" "1498.9" "1982.7" "1873.8" "597.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5964794776079938030" "False" "High" "IsMasterProtein" "P56537" "Eukaryotic translation initiation factor 6 OS=Homo sapiens OX=9606 GN=EIF6 PE=1 SV=1" "0.000" "False" "50.592" "40" "7" "16" "7" "245" "26.6" "4.68" "76.49" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01912" "3692" "ENSG00000242372" "EIF6" "B7ZBG9; hsa:3692; P56537; Q6IBN8; Q96TD5" "Translation factors; Genetic causes of porto-sinusoidal vascular disease" "" "2" "0" "0.950" "1.030" "0.894" "0.995" "0.977" "0.931" "0.979" "1.042" "0.772" "2025.2" "1924.6" "2085.7" "1809.6" "2015.1" "1978.0" "1884.7" "1982.4" "2110.9" "1562.6" "" "" "" "" "" "" "" "" "" "" "1820.9" "1557.3" "1886.6" "1766.4" "1662.9" "1978.0" "1411.2" "1751.0" "1888.8" "557.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2383613337026514959" "False" "High" "IsMasterProtein" "Q93052" "Lipoma-preferred partner OS=Homo sapiens OX=9606 GN=LPP PE=1 SV=1" "0.000" "False" "50.580" "24" "10" "14" "10" "612" "65.7" "7.37" "49.85" "10" "cell adhesion" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00412" "4026" "ENSG00000145012" "LPP" "A1L4L6; D3DNV6; hsa:4026; Q8NFX5; Q93052" "MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement" "" "1" "0" "1.249" "1.001" "1.123" "1.150" "1.130" "1.068" "1.304" "1.096" "0.895" "613.6" "766.6" "614.5" "688.9" "705.5" "693.3" "655.5" "800.1" "672.4" "549.3" "" "" "" "" "" "" "" "" "" "" "551.7" "620.3" "555.8" "672.4" "582.2" "693.3" "490.8" "706.7" "601.7" "196.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4729149100999833326" "False" "High" "IsMasterProtein" "Q9NT62" "Ubiquitin-like-conjugating enzyme ATG3 OS=Homo sapiens OX=9606 GN=ATG3 PE=1 SV=1" "0.000" "False" "50.578" "32" "9" "23" "9" "314" "35.8" "4.74" "92.24" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03987" "64422" "ENSG00000144848" "ATG3" "hsa:64422; Q6PKC5; Q9H6L9; Q9NT62" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "0.955" "0.969" "0.979" "0.993" "0.926" "0.980" "0.994" "0.982" "0.830" "2794.1" "2669.6" "2706.2" "2735.5" "2774.3" "2586.8" "2737.4" "2777.7" "2742.9" "2318.4" "" "" "" "" "" "" "" "" "" "" "2512.2" "2160.2" "2447.9" "2670.2" "2289.4" "2586.8" "2049.7" "2453.5" "2454.3" "827.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658103532290025162" "False" "High" "IsMasterProtein" "P49770" "Translation initiation factor eIF2B subunit beta OS=Homo sapiens OX=9606 GN=EIF2B2 PE=1 SV=3" "0.000" "False" "50.560" "40" "13" "18" "13" "351" "39.0" "6.16" "64.20" "13" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01008" "8892" "ENSG00000119718" "EIF2B2" "hsa:8892; O43201; P49770" "Translation factors; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Rett syndrome; Primary ovarian insufficiency" "Recycling of eIF2:GDP" "5" "0" "0.981" "0.974" "0.970" "0.990" "0.996" "1.064" "1.022" "1.032" "0.787" "967.1" "948.5" "942.2" "938.4" "957.5" "962.8" "1028.6" "988.7" "998.5" "761.0" "" "" "" "" "" "" "" "" "" "" "869.6" "767.5" "852.3" "916.0" "790.1" "962.8" "770.2" "873.3" "893.5" "271.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6890831805190457766" "False" "High" "IsMasterProtein" "Q9BV73" "Centrosome-associated protein CEP250 OS=Homo sapiens OX=9606 GN=CEP250 PE=1 SV=2" "0.000" "False" "50.556" "7" "14" "14" "14" "2442" "281.0" "5.02" "55.66" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15035" "11190" "ENSG00000126001" "CEP250" "E1P5Q3; hsa:11190; O14812; O60588; Q9BV73; Q9H450" "Mesodermal commitment pathway" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.023" "0.974" "0.889" "1.096" "1.035" "0.985" "0.987" "0.998" "1.076" "560.8" "573.8" "545.9" "498.6" "614.5" "580.5" "552.5" "553.6" "559.9" "603.6" "" "" "" "" "" "" "" "" "" "" "504.2" "464.3" "493.8" "486.7" "507.1" "580.5" "413.7" "489.0" "501.0" "215.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4642544614061212331" "False" "High" "IsMasterProtein" "P38159" "RNA-binding motif protein, X chromosome OS=Homo sapiens OX=9606 GN=RBMX PE=1 SV=3" "0.000" "False" "50.551" "33" "14" "26" "4" "391" "42.3" "10.05" "70.01" "14" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08081" "27316" "ENSG00000147274" "RBMX" "B4E3U4; D3DWH0; E9PG86; hsa:27316; P38159; Q5JQ67; Q8N8Y7; Q969R3" "mRNA processing" "RND2 GTPase cycle; mRNA Splicing - Major Pathway; RND3 GTPase cycle; RND1 GTPase cycle; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "8" "8" "0.972" "0.844" "0.894" "0.984" "0.911" "0.939" "0.943" "0.829" "1.271" "2085.4" "2027.0" "1759.5" "1863.7" "2051.8" "1899.5" "1958.9" "1967.2" "1728.9" "2650.0" "" "" "" "" "" "" "" "" "" "" "1875.0" "1640.2" "1591.5" "1819.3" "1693.2" "1899.5" "1466.8" "1737.6" "1547.0" "946.0" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3291285492636401918" "False" "High" "IsMasterProtein" "Q9H974" "Queuine tRNA-ribosyltransferase accessory subunit 2 OS=Homo sapiens OX=9606 GN=QTRT2 PE=1 SV=1" "0.000" "False" "50.541" "31" "11" "15" "11" "415" "46.7" "6.81" "69.50" "11" "RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01702" "79691" "ENSG00000151576" "QTRT2" "A6NGE9; B7Z472; B7Z5R2; hsa:79691; J3KR78; Q6IA59; Q9H974" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.995" "1.020" "0.949" "0.954" "0.974" "0.935" "0.972" "0.982" "0.832" "1315.2" "1308.5" "1341.2" "1247.8" "1254.3" "1281.5" "1229.9" "1278.7" "1291.9" "1093.6" "" "" "" "" "" "" "" "" "" "" "1182.5" "1058.8" "1213.2" "1218.0" "1035.0" "1281.5" "921.0" "1129.4" "1156.0" "390.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9217624131527771053" "False" "High" "IsMasterProtein" "O00330" "Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3" "0.000" "False" "50.465" "28" "12" "23" "12" "501" "54.1" "8.66" "82.08" "12" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00198, Pf00364, Pf02817" "8050" "ENSG00000110435" "PDHX" "B4DW62; D3DR11; E9PB14; E9PBP7; hsa:8050; O00330; O60221; Q96FV8; Q99783" "Amino acid metabolism" "Glyoxylate metabolism and glycine degradation; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "5" "0" "0.998" "0.994" "0.996" "1.021" "0.992" "1.018" "1.008" "1.023" "0.801" "1751.1" "1747.5" "1740.1" "1743.7" "1787.1" "1737.4" "1782.0" "1765.4" "1792.0" "1402.7" "" "" "" "" "" "" "" "" "" "" "1574.4" "1414.0" "1574.0" "1702.0" "1474.8" "1737.4" "1334.3" "1559.3" "1603.5" "500.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6978047849896927875" "False" "High" "IsMasterProtein" "O15234" "Protein CASC3 OS=Homo sapiens OX=9606 GN=CASC3 PE=1 SV=2" "0.000" "False" "50.375" "26" "12" "15" "12" "703" "76.2" "6.48" "58.03" "12" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09405" "22794" "ENSG00000108349" "CASC3" "A8K8R0; O15234" "" "Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "6" "0" "1.033" "1.016" "0.970" "1.012" "1.009" "0.920" "1.086" "1.000" "0.931" "571.7" "590.5" "580.6" "554.8" "578.3" "577.0" "526.1" "621.1" "571.4" "532.0" "" "" "" "" "" "" "" "" "" "" "514.0" "477.8" "525.1" "541.5" "477.2" "577.0" "393.9" "548.6" "511.3" "189.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6901270763620924094" "False" "High" "IsMasterProtein" "Q6P1N9" "Deoxyribonuclease TATDN1 OS=Homo sapiens OX=9606 GN=TATDN1 PE=1 SV=2" "0.000" "False" "50.252" "43" "11" "19" "11" "297" "33.6" "6.96" "68.10" "11" "DNA metabolism" "nucleus" "other molecular function" "Pf01026" "83940" "ENSG00000147687; ENSG00000291730" "TATDN1" "B2R5J0; hsa:83940; Q6P1N9; Q8TD02; Q9BY40" "" "" "0" "0" "1.096" "0.994" "0.956" "1.092" "0.987" "1.055" "1.020" "1.008" "0.876" "972.9" "1066.5" "967.0" "930.5" "1062.3" "960.4" "1026.5" "992.5" "980.9" "852.2" "" "" "" "" "" "" "" "" "" "" "874.7" "862.9" "874.7" "908.3" "876.6" "960.4" "768.6" "876.7" "877.7" "304.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2753103137801597372" "False" "High" "IsMasterProtein" "Q99618" "Cell division cycle-associated protein 3 OS=Homo sapiens OX=9606 GN=CDCA3 PE=1 SV=1" "0.000" "False" "50.251" "54" "11" "18" "11" "268" "29.0" "6.43" "73.61" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "" "" "83461" "ENSG00000111665" "CDCA3" "A8K5V6; D3DUS6; hsa:83461; Q99618" "" "" "0" "0" "0.981" "1.166" "0.935" "0.985" "1.231" "0.942" "0.969" "1.205" "0.817" "1268.8" "1244.9" "1479.1" "1186.9" "1249.5" "1562.1" "1194.6" "1229.7" "1528.8" "1036.7" "" "" "" "" "" "" "" "" "" "" "1140.8" "1007.3" "1337.9" "1158.6" "1031.1" "1562.1" "894.5" "1086.1" "1368.0" "370.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6460139479284416051" "False" "High" "IsMasterProtein" "Q86UK7" "E3 ubiquitin-protein ligase ZNF598 OS=Homo sapiens OX=9606 GN=ZNF598 PE=1 SV=1" "0.000" "False" "50.249" "14" "13" "14" "13" "904" "98.6" "8.40" "57.08" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus" "translation activity;other molecular function" "" "90850" "" "ZNF598" "hsa:90850; Q86UK7; Q8IW49; Q8N3D9; Q96FG3; Q9H7J3" "" "" "0" "0" "1.026" "0.991" "0.961" "0.933" "0.979" "1.057" "0.932" "0.926" "1.295" "1164.5" "1195.2" "1153.5" "1119.0" "1086.3" "1139.6" "1230.9" "1085.4" "1078.9" "1508.4" "" "" "" "" "" "" "" "" "" "" "1047.0" "967.1" "1043.4" "1092.3" "896.4" "1139.6" "921.6" "958.7" "965.4" "538.5" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1575369473679167499" "False" "High" "IsMasterProtein" "Q00059" "Transcription factor A, mitochondrial OS=Homo sapiens OX=9606 GN=TFAM PE=1 SV=1" "0.000" "False" "50.217" "35" "10" "23" "10" "246" "29.1" "9.72" "73.46" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011" "7019" "ENSG00000108064" "TFAM" "A8MRB2; A9QXC6; B5BU05; hsa:7019; Q00059; Q5U0C6" "Energy metabolism; NAD metabolism, sirtuins and aging; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Orexin receptor pathway; Sildenafil treatment" "Mitochondrial protein degradation; Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "9" "0" "0.938" "1.016" "0.988" "1.031" "0.998" "0.975" "1.111" "1.052" "0.862" "1650.7" "1547.6" "1676.5" "1630.6" "1701.2" "1646.8" "1610.1" "1834.2" "1736.3" "1423.6" "" "" "" "" "" "" "" "" "" "" "1484.1" "1252.3" "1516.5" "1591.7" "1403.8" "1646.8" "1205.6" "1620.1" "1553.6" "508.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369435830510499583" "False" "High" "IsMasterProtein" "Q9GZP4" "PITH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PITHD1 PE=1 SV=1" "0.000" "False" "50.200" "61" "13" "20" "13" "211" "24.2" "5.74" "63.82" "13" "other biological processes" "other cell component" "" "Pf06201" "57095" "ENSG00000057757" "PITHD1" "B2R7J4; hsa:57095; Q5QPN6; Q5QPN7; Q9GZP4; Q9NRI8" "" "" "0" "0" "0.985" "1.011" "0.984" "1.077" "0.986" "0.986" "0.903" "1.020" "0.880" "1656.0" "1630.5" "1674.8" "1628.9" "1783.4" "1633.3" "1632.3" "1494.7" "1689.7" "1457.4" "" "" "" "" "" "" "" "" "" "" "1488.9" "1319.3" "1514.9" "1590.0" "1471.7" "1633.3" "1222.2" "1320.2" "1511.9" "520.2" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2561010377563702326" "False" "High" "IsMasterProtein" "Q8WX92" "Negative elongation factor B OS=Homo sapiens OX=9606 GN=NELFB PE=1 SV=1" "0.000" "False" "50.172" "23" "12" "14" "12" "580" "65.7" "6.13" "58.19" "12" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf06209" "25920" "ENSG00000188986" "NELFB" "A0A0X1KG71; A2BFA3; hsa:25920; Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation; 5q35 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes; NTRK3 as a dependence receptor" "18" "0" "1.033" "1.022" "0.983" "1.056" "1.024" "1.014" "1.069" "1.083" "1.284" "1367.2" "1412.5" "1396.7" "1343.6" "1443.3" "1400.2" "1387.0" "1461.8" "1480.4" "1755.9" "" "" "" "" "" "" "" "" "" "" "1229.2" "1143.0" "1263.4" "1311.6" "1191.1" "1400.2" "1038.5" "1291.2" "1324.7" "626.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7223228418441482962" "False" "High" "IsMasterProtein" "Q15648" "Mediator of RNA polymerase II transcription subunit 1 OS=Homo sapiens OX=9606 GN=MED1 PE=1 SV=4" "0.000" "False" "50.107" "10" "13" "15" "13" "1581" "168.4" "8.73" "60.01" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf10744" "5469" "ENSG00000125686" "MED1" "A2RRQ6; hsa:5469; O43810; O75447; Q15648; Q6P9H7; Q6PK58; Q9HD39" "Energy metabolism; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Non-genomic actions of 1,25 dihydroxyvitamin D3; 17q12 copy number variation syndrome" "Estrogen-dependent gene expression; Transcriptional activation of mitochondrial biogenesis; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Nuclear Receptor transcription pathway; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "18" "0" "1.055" "1.041" "0.968" "0.990" "1.051" "0.981" "0.931" "1.001" "0.965" "955.4" "1007.8" "994.3" "925.2" "946.2" "1004.6" "937.7" "889.2" "956.7" "922.2" "" "" "" "" "" "" "" "" "" "" "859.0" "815.5" "899.4" "903.2" "780.8" "1004.6" "702.1" "785.4" "856.0" "329.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "866424040394030727" "False" "High" "IsMasterProtein" "Q15052" "Rho guanine nucleotide exchange factor 6 OS=Homo sapiens OX=9606 GN=ARHGEF6 PE=1 SV=2" "0.000" "False" "50.085" "17" "12" "16" "10" "776" "87.4" "6.05" "61.05" "12" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00307, Pf00621, Pf07653, Pf16523, Pf16614, Pf16615" "9459" "ENSG00000129675" "ARHGEF6" "A6NMW9; A8K6S7; B1AL37; hsa:9459; Q15052; Q15396; Q5JQ66; Q7Z3W1; Q86XH0" "Pancreatic adenocarcinoma pathway; Regulation of actin cytoskeleton" "G alpha (12/13) signalling events; G beta:gamma signalling through CDC42; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOU GTPase cycle; NRAGE signals death through JNK; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "9" "0" "0.960" "0.967" "0.974" "0.972" "0.932" "1.019" "0.984" "0.972" "1.789" "779.7" "748.3" "753.9" "759.5" "757.8" "727.0" "794.6" "767.4" "758.1" "1395.1" "" "" "" "" "" "" "" "" "" "" "701.1" "605.5" "681.9" "741.4" "625.4" "727.0" "595.0" "677.8" "678.3" "498.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7717168989126712836" "False" "High" "IsMasterProtein" "Q8TAF3" "WD repeat-containing protein 48 OS=Homo sapiens OX=9606 GN=WDR48 PE=1 SV=1" "0.000" "False" "50.032" "18" "11" "16" "11" "677" "76.2" "7.03" "56.62" "11" "DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00400, Pf11816" "57599" "ENSG00000114742" "WDR48" "B4DM86; B4DQI2; B4DY84; hsa:57599; Q63HJ2; Q658Y1; Q8N3Z1; Q8TAF3; Q9NSK8; Q9P279" "DNA repair pathways, full network" "Ub-specific processing proteases; Recognition of DNA damage by PCNA-containing replication complex; Fanconi Anemia Pathway; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "5" "0" "1.044" "0.908" "0.928" "1.087" "0.920" "1.011" "0.970" "0.934" "0.935" "932.9" "973.6" "846.7" "865.4" "1014.2" "858.4" "942.9" "905.1" "871.3" "872.2" "" "" "" "" "" "" "" "" "" "" "838.8" "787.8" "765.9" "844.8" "836.9" "858.4" "706.0" "799.5" "779.7" "311.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6313231503744566384" "False" "High" "IsMasterProtein" "O00754" "Lysosomal alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B1 PE=1 SV=3" "0.000" "False" "50.010" "14" "13" "16" "13" "1011" "113.7" "7.28" "59.20" "13" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf21260" "4125" "ENSG00000104774" "MAN2B1" "G5E928; hsa:4125; O00754; O15330; Q16680; Q93094; Q9BW13" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "1.017" "1.043" "1.049" "1.118" "1.076" "1.045" "1.015" "1.175" "0.922" "1597.8" "1624.2" "1665.9" "1675.6" "1786.9" "1719.7" "1669.7" "1621.1" "1877.5" "1472.7" "" "" "" "" "" "" "" "" "" "" "1436.5" "1314.2" "1506.8" "1635.6" "1474.6" "1719.7" "1250.3" "1431.9" "1679.9" "525.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5085231935458707065" "False" "High" "IsMasterProtein" "O75530" "Polycomb protein EED OS=Homo sapiens OX=9606 GN=EED PE=1 SV=2" "0.000" "False" "49.956" "32" "13" "17" "13" "441" "50.2" "7.03" "57.70" "13" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "8726" "ENSG00000074266" "EED" "A8K7V5; hsa:8726; O00149; O75530; Q6NTH2; Q7LDA5; Q7LDG8; Q86VV2; Q9UNY7" "Histone modifications; Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA; Defective pyroptosis" "15" "0" "1.026" "1.127" "0.928" "1.002" "1.058" "0.954" "0.969" "1.013" "0.884" "1451.4" "1488.7" "1635.0" "1346.7" "1454.5" "1535.3" "1384.3" "1406.6" "1469.9" "1283.5" "" "" "" "" "" "" "" "" "" "" "1304.9" "1204.6" "1478.9" "1314.6" "1200.3" "1535.3" "1036.5" "1242.4" "1315.2" "458.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6179525910857735181" "False" "High" "IsMasterProtein" "P49590" "Histidine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=HARS2 PE=1 SV=1" "0.000" "False" "49.949" "18" "10" "22" "3" "506" "56.9" "8.24" "70.70" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf03129, Pf13393" "23438" "ENSG00000112855" "HARS2" "B4DDY8; hsa:23438; P49590" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "1.138" "1.049" "0.992" "1.194" "1.049" "1.033" "1.077" "1.106" "1.128" "219.0" "249.3" "229.8" "217.3" "261.4" "229.8" "226.1" "235.8" "242.1" "247.0" "" "" "" "" "" "" "" "" "" "" "196.9" "201.7" "207.8" "212.1" "215.7" "229.8" "169.3" "208.3" "216.6" "88.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5623462440984321357" "False" "High" "IsMasterProtein" "Q96CW5" "Gamma-tubulin complex component 3 OS=Homo sapiens OX=9606 GN=TUBGCP3 PE=1 SV=2" "0.000" "False" "49.917" "18" "13" "16" "13" "907" "103.5" "8.12" "64.79" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf04130, Pf17681" "10426" "ENSG00000126216" "TUBGCP3" "hsa:10426; O43631; O60852; O60853; Q5T8L2; Q7Z4K1; Q96CW5; Q96I79" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "0.920" "0.951" "0.938" "0.957" "0.923" "1.005" "0.912" "0.914" "1.163" "805.7" "741.4" "766.3" "755.9" "771.2" "744.1" "809.9" "734.6" "736.6" "937.1" "" "" "" "" "" "" "" "" "" "" "724.4" "599.9" "693.1" "737.9" "636.4" "744.1" "606.4" "648.8" "659.1" "334.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5097285546309815512" "False" "High" "IsMasterProtein" "Q8NEB9" "Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Homo sapiens OX=9606 GN=PIK3C3 PE=1 SV=1" "0.000" "False" "49.916" "16" "13" "20" "13" "887" "101.5" "6.81" "63.81" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792" "5289" "ENSG00000078142" "PIK3C3" "hsa:5289; Q15134; Q8NEB9" "AMP-activated protein kinase signaling; Alzheimer's disease and miRNA effects; Angiopoietin-like protein 8 regulatory pathway; Microglia pathogen phagocytosis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Osteoblast differentiation and related diseases; Insulin signaling; Autophagy; Regulation of actin cytoskeleton; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP; DNA damage response (only ATM dependent)" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; PI3K Cascade; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; RHO GTPases Activate NADPH Oxidases; Toll Like Receptor 9 (TLR9) Cascade" "24" "0" "1.030" "1.041" "1.029" "1.093" "1.074" "1.073" "0.985" "1.068" "1.171" "953.6" "981.8" "992.4" "981.0" "1042.3" "1024.1" "1023.5" "938.9" "1018.7" "1116.5" "" "" "" "" "" "" "" "" "" "" "857.4" "794.4" "897.6" "957.6" "860.1" "1024.1" "766.3" "829.3" "911.5" "398.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "291264612704325176" "False" "High" "IsMasterProtein" "Q13685" "Angio-associated migratory cell protein OS=Homo sapiens OX=9606 GN=AAMP PE=1 SV=2" "0.000" "False" "49.903" "26" "10" "16" "10" "434" "46.7" "4.42" "62.36" "10" "developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00400" "14" "ENSG00000127837" "AAMP" "hsa:14; Q13685; Q8WUJ9; Q96H92" "Nucleotide-binding oligomerization domain (NOD) pathway" "Thromboxane signalling through TP receptor; Signaling by EGFR; NOD1/2 Signaling Pathway; Signaling by VEGF" "5" "0" "1.018" "1.107" "0.980" "1.010" "1.088" "0.965" "0.973" "1.139" "0.924" "1761.0" "1792.4" "1949.7" "1725.6" "1778.8" "1916.7" "1699.9" "1714.1" "2006.1" "1626.4" "" "" "" "" "" "" "" "" "" "" "1583.3" "1450.3" "1763.6" "1684.4" "1467.9" "1916.7" "1272.9" "1514.0" "1795.0" "580.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3045251361027418727" "False" "High" "IsMasterProtein" "O43237" "Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens OX=9606 GN=DYNC1LI2 PE=1 SV=1" "0.000" "False" "49.842" "34" "12" "16" "11" "492" "54.1" "6.38" "57.65" "12" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05783" "1783" "ENSG00000135720" "DYNC1LI2" "A8K6V1; B4DZP4; hsa:1783; O43237; Q8TAT3" "Intraflagellar transport proteins binding to dynein; Vasopressin-regulated water reabsorption" "HCMV Early Events; COPI-mediated anterograde transport; Separation of Sister Chromatids; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "14" "0" "0.978" "0.970" "1.018" "1.020" "0.999" "1.002" "1.007" "1.022" "0.980" "1059.8" "1036.6" "1028.5" "1079.0" "1080.5" "1059.0" "1061.7" "1067.5" "1083.4" "1038.1" "" "" "" "" "" "" "" "" "" "" "952.8" "838.8" "930.3" "1053.3" "891.7" "1059.0" "795.0" "942.9" "969.5" "370.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1819125433981479748" "False" "High" "IsMasterProtein" "Q15404" "Ras suppressor protein 1 OS=Homo sapiens OX=9606 GN=RSU1 PE=1 SV=3" "0.000" "False" "49.813" "39" "11" "27" "11" "277" "31.5" "8.65" "82.15" "11" "signal transduction;other biological processes" "cytosol;other cell component" "" "Pf13855" "6251" "ENSG00000148484" "RSU1" "A8KA46; D3DRU3; hsa:6251; Q15404; Q6FI17" "" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "1" "0" "1.012" "1.031" "0.983" "1.057" "1.023" "0.974" "1.009" "1.103" "0.896" "2183.6" "2210.6" "2251.5" "2146.9" "2309.2" "2233.5" "2126.6" "2203.7" "2407.6" "1955.8" "" "" "" "" "" "" "" "" "" "" "1963.3" "1788.8" "2036.5" "2095.7" "1905.6" "2233.5" "1592.3" "1946.4" "2154.3" "698.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3445317151605985554" "False" "High" "IsMasterProtein" "Q13356" "RING-type E3 ubiquitin-protein ligase PPIL2 OS=Homo sapiens OX=9606 GN=PPIL2 PE=1 SV=1" "0.000" "False" "49.773" "33" "13" "14" "13" "520" "58.8" "8.78" "60.63" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00160" "23759" "ENSG00000100023" "PPIL2" "Q13356; Q13357; Q8TAH2; Q9BWR8" "" "mRNA Splicing - Major Pathway; Basigin interactions" "2" "0" "0.989" "1.004" "0.967" "0.982" "1.010" "0.984" "0.967" "1.022" "1.347" "1133.9" "1121.0" "1138.3" "1096.6" "1113.3" "1144.9" "1115.4" "1096.0" "1158.3" "1527.0" "" "" "" "" "" "" "" "" "" "" "1019.5" "907.1" "1029.6" "1070.4" "918.7" "1144.9" "835.2" "968.0" "1036.4" "545.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3006741669515463279" "False" "High" "IsMasterProtein" "Q8WUD1" "Ras-related protein Rab-2B OS=Homo sapiens OX=9606 GN=RAB2B PE=1 SV=1" "0.000" "False" "49.754" "39" "8" "18" "1" "216" "24.2" "7.83" "74.15" "8" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "84932" "ENSG00000129472" "RAB2B" "B2RD03; D3DS24; hsa:84932; Q6NZ33; Q8WUD1" "" "RAB geranylgeranylation" "1" "0" "1.123" "1.105" "0.977" "1.307" "1.004" "0.907" "0.986" "1.036" "0.889" "45.9" "51.5" "50.7" "44.8" "59.9" "46.0" "41.6" "45.2" "47.5" "40.7" "" "" "" "" "" "" "" "" "" "" "41.2" "41.7" "45.8" "43.7" "49.4" "46.0" "31.1" "39.9" "42.5" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3304952133381549298" "False" "High" "IsMasterProtein" "Q99614" "Tetratricopeptide repeat protein 1 OS=Homo sapiens OX=9606 GN=TTC1 PE=1 SV=1" "0.000" "False" "49.751" "38" "10" "20" "10" "292" "33.5" "4.84" "67.73" "10" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00515, Pf13181" "7265" "ENSG00000113312" "TTC1" "B2RCT2; D3DQJ8; hsa:7265; Q99614; Q9BVT3" "" "" "0" "0" "0.850" "0.958" "0.950" "0.948" "0.948" "0.910" "0.996" "0.994" "0.761" "2247.5" "1910.0" "2152.2" "2134.4" "2131.0" "2131.0" "2045.1" "2239.1" "2234.7" "1711.2" "" "" "" "" "" "" "" "" "" "" "2020.7" "1545.5" "1946.8" "2083.5" "1758.5" "2131.0" "1531.3" "1977.7" "1999.6" "610.9" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5852345656663566721" "False" "High" "IsMasterProtein" "Q5JSL3" "Dedicator of cytokinesis protein 11 OS=Homo sapiens OX=9606 GN=DOCK11 PE=1 SV=2" "0.000" "False" "49.743" "8" "16" "18" "16" "2073" "237.5" "7.74" "63.86" "16" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00169, Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "139818" "ENSG00000147251" "DOCK11" "A6NMF0; hsa:139818; Q5JSL3; Q66M66; Q6ZUJ5; Q86VU8; Q96MN3" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; Factors involved in megakaryocyte development and platelet production" "3" "0" "0.962" "0.926" "0.931" "1.004" "0.912" "1.019" "0.966" "0.900" "1.014" "810.7" "780.0" "751.0" "754.7" "814.1" "739.7" "826.0" "782.8" "729.7" "822.5" "" "" "" "" "" "" "" "" "" "" "728.9" "631.1" "679.3" "736.7" "671.8" "739.7" "618.5" "691.4" "653.0" "293.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6803776007100694472" "False" "High" "IsMasterProtein" "P51580" "Thiopurine S-methyltransferase OS=Homo sapiens OX=9606 GN=TPMT PE=1 SV=1" "0.000" "False" "49.733" "51" "12" "18" "12" "245" "28.2" "6.23" "67.90" "12" "other metabolic processes" "cytosol" "other molecular function" "Pf05724" "7172" "ENSG00000137364" "TPMT" "hsa:7172; O14806; O15423; O15424; O15425; O15426; O15515; O15548; O43213; P51580; Q5VUK6; Q9UBE6; Q9UBT8; Q9UE62" "Metapathway biotransformation Phase I and II; Methylation pathways" "Azathioprine ADME; Methylation; Defective TPMT causes TPMT deficiency" "5" "0" "1.021" "1.017" "0.948" "1.029" "0.955" "0.975" "1.031" "1.016" "0.770" "1412.6" "1442.8" "1436.7" "1339.4" "1454.0" "1349.7" "1377.1" "1456.1" "1434.7" "1087.6" "" "" "" "" "" "" "" "" "" "" "1270.1" "1167.4" "1299.6" "1307.4" "1199.9" "1349.7" "1031.1" "1286.1" "1283.8" "388.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5987314834012537405" "False" "High" "IsMasterProtein" "O60888" "Protein CutA OS=Homo sapiens OX=9606 GN=CUTA PE=1 SV=2" "0.000" "False" "49.711" "39" "5" "19" "5" "179" "19.1" "5.50" "77.33" "5" "other biological processes" "other membranes" "other molecular function" "Pf03091" "51596" "ENSG00000112514; ENSG00000226492" "CUTA" "A2AB26; A2BEL4; hsa:51596; O60888; Q3B784; Q5JXM9; Q5SU05; Q9NYQ9" "" "" "0" "0" "0.913" "0.995" "0.953" "1.096" "1.090" "1.124" "1.059" "0.998" "0.800" "1198.4" "1094.0" "1192.9" "1142.5" "1313.6" "1306.2" "1347.5" "1269.2" "1196.1" "958.4" "" "" "" "" "" "" "" "" "" "" "1077.5" "885.2" "1079.0" "1115.3" "1084.0" "1306.2" "1009.0" "1121.0" "1070.3" "342.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8372926252788997109" "False" "High" "IsMasterProtein" "Q5JTZ9" "Alanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=AARS2 PE=1 SV=1" "0.000" "False" "49.704" "18" "17" "20" "17" "985" "107.3" "6.27" "53.63" "17" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf01411, Pf07973" "57505" "ENSG00000124608" "AARS2" "A2RRN5; hsa:57505; Q5JTZ9; Q8N198; Q96D02; Q9ULF0" "Primary ovarian insufficiency" "Mitochondrial tRNA aminoacylation" "2" "0" "1.017" "1.029" "1.013" "1.053" "0.987" "1.008" "1.023" "1.004" "1.170" "751.9" "764.6" "773.4" "761.7" "792.1" "741.9" "758.3" "769.2" "755.0" "879.8" "" "" "" "" "" "" "" "" "" "" "676.1" "618.6" "699.6" "743.5" "653.7" "741.9" "567.8" "679.4" "675.6" "314.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2886709730536475345" "False" "High" "IsMasterProtein" "Q9BTT0" "Acidic leucine-rich nuclear phosphoprotein 32 family member E OS=Homo sapiens OX=9606 GN=ANP32E PE=1 SV=1" "0.000" "False" "49.703" "39" "7" "18" "7" "268" "30.7" "3.85" "77.38" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf14580" "81611" "ENSG00000143401" "ANP32E" "B4E0I6; E9PEA6; hsa:81611; Q5TB18; Q5TB20; Q8N1S4; Q8WWW9; Q9BTT0" "" "" "0" "0" "1.011" "1.081" "1.009" "1.019" "1.260" "1.004" "1.183" "0.983" "3.024" "1501.2" "1517.4" "1622.6" "1514.7" "1529.8" "1892.0" "1507.7" "1776.5" "1475.0" "4540.1" "" "" "" "" "" "" "" "" "" "" "1349.7" "1227.8" "1467.7" "1478.5" "1262.4" "1892.0" "1128.9" "1569.1" "1319.9" "1620.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945611468628581935" "False" "High" "IsMasterProtein" "Q96I25" "Splicing factor 45 OS=Homo sapiens OX=9606 GN=RBM17 PE=1 SV=1" "0.000" "False" "49.702" "38" "13" "15" "13" "401" "44.9" "5.97" "58.00" "13" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf01585" "84991" "ENSG00000134453" "RBM17" "hsa:84991; Q96GY6; Q96I25" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.931" "1.013" "0.904" "0.963" "1.018" "0.958" "0.891" "0.904" "1.114" "1215.8" "1132.2" "1232.1" "1099.2" "1170.5" "1237.3" "1164.4" "1082.9" "1098.8" "1354.7" "" "" "" "" "" "" "" "" "" "" "1093.1" "916.1" "1114.5" "1073.0" "965.9" "1237.3" "871.9" "956.4" "983.2" "483.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700006474042265009" "False" "High" "IsMasterProtein" "Q7Z739" "YTH domain-containing family protein 3 OS=Homo sapiens OX=9606 GN=YTHDF3 PE=1 SV=1" "0.000" "False" "49.697" "23" "12" "21" "9" "585" "63.8" "9.04" "71.46" "12" "cell organization and biogenesis;other biological processes" "cytosol;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf04146" "253943" "ENSG00000185728" "YTHDF3" "B3KXL4; hsa:253943; Q63Z37; Q659A3; Q7Z739" "" "" "0" "0" "0.953" "0.988" "0.884" "0.890" "0.912" "0.872" "0.885" "0.881" "0.849" "1306.5" "1244.5" "1290.8" "1155.5" "1162.2" "1191.2" "1139.3" "1156.4" "1150.9" "1108.8" "" "" "" "" "" "" "" "" "" "" "1174.6" "1007.0" "1167.6" "1127.9" "959.0" "1191.2" "853.1" "1021.4" "1029.8" "395.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3180744532399736086" "False" "High" "IsMasterProtein" "Q15814" "Tubulin-specific chaperone C OS=Homo sapiens OX=9606 GN=TBCC PE=1 SV=2" "0.000" "False" "49.645" "37" "11" "16" "10" "346" "39.2" "5.71" "62.60" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07986, Pf16752" "6903" "ENSG00000124659" "TBCC" "hsa:6903; Q15814; Q53Y43; Q5T787" "" "Post-chaperonin tubulin folding pathway" "1" "0" "1.035" "0.960" "0.933" "1.054" "0.953" "0.994" "0.998" "0.966" "0.866" "1652.1" "1710.5" "1585.9" "1541.8" "1740.6" "1574.6" "1641.6" "1648.0" "1596.6" "1430.4" "" "" "" "" "" "" "" "" "" "" "1485.4" "1384.0" "1434.5" "1505.0" "1436.4" "1574.6" "1229.2" "1455.6" "1428.6" "510.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6789229082663828317" "False" "High" "IsMasterProtein" "Q6ZUJ8" "Phosphoinositide 3-kinase adapter protein 1 OS=Homo sapiens OX=9606 GN=PIK3AP1 PE=1 SV=2" "0.000" "False" "49.630" "16" "10" "15" "10" "805" "90.3" "5.40" "62.69" "10" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "118788" "ENSG00000155629" "PIK3AP1" "hsa:118788; Q5TB56; Q5VXJ9; Q6ZUJ8; Q8N6J6; Q8NAC8" "B cell receptor signaling pathway; PI3K-Akt signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "6" "0" "1.009" "1.112" "0.977" "0.994" "1.061" "0.930" "0.962" "1.122" "3.643" "917.1" "925.5" "1019.6" "895.6" "912.1" "973.0" "853.4" "882.1" "1029.2" "3341.0" "" "" "" "" "" "" "" "" "" "" "824.6" "748.9" "922.2" "874.2" "752.6" "973.0" "639.0" "779.1" "920.9" "1192.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3823742586445689125" "False" "High" "IsMasterProtein" "Q9NPQ8" "Synembryn-A OS=Homo sapiens OX=9606 GN=RIC8A PE=1 SV=3" "0.000" "False" "49.626" "27" "12" "18" "12" "531" "59.7" "5.33" "71.96" "12" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf10165" "60626" "ENSG00000177963" "RIC8A" "hsa:60626; Q0P508; Q2T9J1; Q7Z352; Q96EZ1; Q96SZ2; Q9H064; Q9H5H3; Q9H9E7; Q9NPQ8" "" "" "0" "0" "1.095" "1.048" "0.990" "1.040" "1.038" "1.086" "1.051" "1.043" "0.749" "900.1" "985.3" "942.9" "891.4" "936.1" "933.8" "977.8" "945.8" "938.9" "674.5" "" "" "" "" "" "" "" "" "" "" "809.2" "797.3" "852.9" "870.1" "772.5" "933.8" "732.1" "835.4" "840.1" "240.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105726009165371323" "False" "High" "IsMasterProtein" "P13995" "Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=MTHFD2 PE=1 SV=2" "0.000" "False" "49.603" "32" "10" "25" "10" "350" "37.9" "8.73" "99.18" "10" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00763, Pf02882" "10797" "ENSG00000065911" "MTHFD2" "hsa:10797; P13995; Q53G90; Q53GV5; Q53S36; Q7Z650" "Folate metabolism; One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways" "Metabolism of folate and pterines" "4" "0" "1.014" "0.971" "0.885" "0.989" "0.922" "0.951" "0.967" "0.936" "0.860" "2519.2" "2555.0" "2446.5" "2230.2" "2490.7" "2323.3" "2396.7" "2437.0" "2358.7" "2167.3" "" "" "" "" "" "" "" "" "" "" "2265.0" "2067.4" "2213.0" "2177.0" "2055.4" "2323.3" "1794.6" "2152.5" "2110.5" "773.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2429714834335380006" "False" "High" "IsMasterProtein" "P40818" "Ubiquitin carboxyl-terminal hydrolase 8 OS=Homo sapiens OX=9606 GN=USP8 PE=1 SV=1" "0.000" "False" "49.578" "16" "17" "18" "17" "1118" "127.4" "8.51" "55.11" "17" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00443, Pf00581, Pf08969, Pf20625" "9101" "ENSG00000138592" "USP8" "B4DKA8; hsa:9101; P40818; Q2TB31; Q7Z3U2; Q86VA0; Q8IWI7" "EGF/EGFR signaling pathway; Male infertility" "Negative regulation of MET activity; Ub-specific processing proteases; Downregulation of ERBB2:ERBB3 signaling; Regulation of FZD by ubiquitination" "6" "0" "1.029" "1.046" "1.065" "1.004" "0.981" "1.021" "0.965" "0.983" "1.649" "1221.7" "1257.1" "1277.7" "1301.1" "1226.3" "1197.9" "1247.3" "1179.5" "1200.9" "2014.4" "" "" "" "" "" "" "" "" "" "" "1098.4" "1017.2" "1155.7" "1270.1" "1012.0" "1197.9" "934.0" "1041.8" "1074.5" "719.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2931302988534192752" "False" "High" "IsMasterProtein" "Q53QZ3" "Rho GTPase-activating protein 15 OS=Homo sapiens OX=9606 GN=ARHGAP15 PE=1 SV=2" "0.000" "False" "49.569" "31" "13" "16" "13" "475" "54.5" "9.39" "62.31" "13" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00169, Pf00620" "55843" "ENSG00000075884" "ARHGAP15" "hsa:55843; Q53QZ3; Q53R36; Q53RD7; Q53RT6; Q53SX9; Q584N9; Q6PJE6; Q86WP1; Q8IXX1; Q9NRL8; Q9NZ77; Q9NZ91" "Ectoderm differentiation; Ectoderm differentiation" "RAC1 GTPase cycle; RAC3 GTPase cycle" "4" "0" "1.147" "1.093" "1.073" "1.120" "1.152" "1.125" "1.128" "1.227" "2.346" "1393.4" "1598.7" "1522.6" "1495.1" "1560.5" "1605.2" "1567.0" "1571.4" "1709.4" "3269.4" "" "" "" "" "" "" "" "" "" "" "1252.8" "1293.6" "1377.2" "1459.4" "1287.8" "1605.2" "1173.4" "1387.9" "1529.6" "1167.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4344816618369671433" "False" "High" "IsMasterProtein" "Q16537" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Homo sapiens OX=9606 GN=PPP2R5E PE=1 SV=1" "0.000" "False" "49.558" "24" "11" "19" "9" "467" "54.7" "6.95" "78.66" "11" "signal transduction" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5529" "ENSG00000154001" "PPP2R5E" "A4FU37; B7ZAW5; B7ZKK8; B7ZKK9; hsa:5529; J3KQN6; Q16537; Q52LW4" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "28" "1" "1.019" "0.978" "0.956" "1.034" "0.946" "0.936" "0.991" "0.938" "1.186" "1256.0" "1280.1" "1227.7" "1201.3" "1299.1" "1187.5" "1175.4" "1245.0" "1178.7" "1489.7" "" "" "" "" "" "" "" "" "" "" "1129.2" "1035.8" "1110.5" "1172.6" "1072.0" "1187.5" "880.1" "1099.7" "1054.7" "531.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-381937601164646059" "False" "High" "IsMasterProtein" "Q15257" "Serine/threonine-protein phosphatase 2A activator OS=Homo sapiens OX=9606 GN=PTPA PE=1 SV=3" "0.000" "False" "49.534" "35" "11" "21" "11" "358" "40.6" "5.94" "72.75" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf03095" "5524" "ENSG00000119383" "PTPA" "A2A347; A9IZU4; B4DXM4; hsa:5524; Q15257; Q15258; Q53GZ3; Q5TZQ2; Q9BUK1; Q9NNZ7; Q9NNZ8; Q9NNZ9" "Interleukin-11 signaling pathway; Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Wnt signaling pathway and pluripotency; Netrin-UNC5B signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "" "7" "0" "0.991" "0.982" "0.985" "1.040" "0.965" "0.991" "1.019" "1.019" "0.847" "1799.8" "1783.2" "1767.0" "1772.4" "1871.3" "1736.0" "1783.7" "1834.7" "1833.9" "1523.8" "" "" "" "" "" "" "" "" "" "" "1618.2" "1442.9" "1598.3" "1730.1" "1544.2" "1736.0" "1335.6" "1620.5" "1640.9" "543.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949132700508493695" "False" "High" "IsMasterProtein" "Q8WW59" "SPRY domain-containing protein 4 OS=Homo sapiens OX=9606 GN=SPRYD4 PE=1 SV=3" "0.000" "False" "49.473" "59" "11" "15" "11" "207" "23.1" "6.93" "58.35" "11" "" "nucleus" "" "Pf00622" "283377" "ENSG00000176422" "SPRYD4" "A8K7A5; hsa:283377; Q8WW59" "" "" "0" "0" "1.000" "1.122" "0.962" "1.065" "1.025" "1.073" "1.004" "1.037" "0.843" "1375.6" "1375.7" "1543.7" "1322.8" "1464.6" "1409.3" "1476.2" "1380.4" "1425.9" "1160.0" "" "" "" "" "" "" "" "" "" "" "1236.8" "1113.2" "1396.3" "1291.3" "1208.6" "1409.3" "1105.3" "1219.3" "1275.9" "414.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8973056022317677667" "False" "High" "IsMasterProtein" "Q9BVS4" "Serine/threonine-protein kinase RIO2 OS=Homo sapiens OX=9606 GN=RIOK2 PE=1 SV=2" "0.000" "False" "49.375" "28" "11" "16" "11" "552" "63.2" "5.94" "47.06" "11" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163, Pf09202" "55781" "ENSG00000058729" "RIOK2" "D6RDI3; hsa:55781; Q9BVS4; Q9NUT0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.026" "0.945" "0.980" "1.028" "0.921" "1.015" "0.998" "0.918" "0.868" "914.1" "938.1" "864.0" "896.1" "939.3" "841.7" "927.6" "912.6" "839.4" "793.0" "" "" "" "" "" "" "" "" "" "" "821.9" "759.1" "781.5" "874.8" "775.1" "841.7" "694.6" "806.1" "751.1" "283.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561643854279228847" "False" "High" "IsMasterProtein" "P15927" "Replication protein A 32 kDa subunit OS=Homo sapiens OX=9606 GN=RPA2 PE=1 SV=1" "0.000" "False" "49.371" "38" "7" "21" "7" "270" "29.2" "6.15" "80.28" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08784" "6118" "ENSG00000117748" "RPA2" "hsa:6118; P15927; Q52II0; Q5TEI9; Q5TEJ5" "miRNA regulation of DNA damage response; Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "38" "0" "1.062" "1.086" "1.071" "1.200" "1.207" "1.152" "1.126" "1.182" "0.940" "1338.5" "1421.7" "1453.7" "1433.0" "1605.8" "1615.5" "1542.1" "1507.6" "1581.6" "1258.5" "" "" "" "" "" "" "" "" "" "" "1203.5" "1150.4" "1314.9" "1398.8" "1325.1" "1615.5" "1154.7" "1331.6" "1415.2" "449.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6670005547915153643" "False" "High" "IsMasterProtein" "O15400" "Syntaxin-7 OS=Homo sapiens OX=9606 GN=STX7 PE=1 SV=4" "0.000" "False" "49.288" "46" "9" "21" "9" "261" "29.8" "5.55" "95.53" "9" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "8417" "ENSG00000079950" "STX7" "E1P579; hsa:8417; O15400; Q5SZW2; Q96ES9" "" "" "0" "0" "1.038" "0.915" "0.988" "1.016" "1.019" "1.120" "1.028" "0.932" "0.755" "2058.5" "2136.5" "1884.5" "2034.5" "2090.6" "2098.6" "2304.5" "2116.4" "1918.8" "1553.5" "" "" "" "" "" "" "" "" "" "" "1850.8" "1728.8" "1704.6" "1986.0" "1725.2" "2098.6" "1725.6" "1869.4" "1716.9" "554.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3062212909163771863" "False" "High" "IsMasterProtein" "P19838" "Nuclear factor NF-kappa-B p105 subunit OS=Homo sapiens OX=9606 GN=NFKB1 PE=1 SV=2" "0.000" "False" "49.230" "16" "15" "16" "15" "968" "105.3" "5.40" "57.73" "15" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4790" "ENSG00000109320" "NFKB1" "A8K5Y5; B3KVE8; hsa:4790; P19838; Q68D84; Q86V43; Q8N4X7; Q9NZC0" "Osteopontin signaling; Selenium micronutrient network; Vitamin B12 metabolism; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Folate metabolism; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Neural crest differentiation; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; PDGF pathway; Apoptosis; T cell receptor and co-stimulatory signaling; Aryl hydrocarbon receptor pathway; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Selenium metabolism and selenoproteins; Apoptosis-related network due to altered Notch3 in ovarian cancer; IL1 and megakaryocytes in obesity; Myometrial relaxation and contraction pathways; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Photodynamic therapy-induced NF-kB survival signaling; NAD metabolism, sirtuins and aging; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; Prion disease pathway; NO/cGMP/PKG mediated neuroprotection; Oxidative stress response; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Non-genomic actions of 1,25 dihydroxyvitamin D3; Ciliary landscape; Nonalcoholic fatty liver disease; LTF danger signal response pathway; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Canonical NF-kB pathway; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Aspirin and miRNAs; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; FGF23 signaling in hypophosphatemic rickets and related disorders; TGF-beta receptor signaling in skeletal dysplasias; Kisspeptin/kisspeptin receptor system in the ovary; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; STING pathway in Kawasaki-like disease and COVID-19; RAS and bradykinin pathways in COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Prostaglandin signaling; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Inclusion body myositis; Alzheimer's disease; Th17 cell differentiation pathway; Lung pathology of COVID-19; Ulcerative colitis signaling; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Inflammatory bowel disease signaling; Role of ROS in COVID-19 endothelial dysfunction; Genetic causes of porto-sinusoidal vascular disease; Acute myeloid leukemia; TROP2 regulatory signaling; Autophagy in pancreatic ductal adenocarcinoma; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; 10q22q23 copy number variation; IL-19 signaling pathway; GNAQ pathways in port-wine stain; TGF-beta receptor signaling; Notch signaling pathway; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; Neutrophil degranulation; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; PKMTs methylate histone lysines; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; Regulation of NFE2L2 gene expression; CD209 (DC-SIGN) signaling; Interleukin-1 processing; CLEC7A/inflammasome pathway; Regulated proteolysis of p75NTR; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "151" "0" "1.057" "0.982" "0.970" "1.043" "0.929" "1.050" "1.008" "0.969" "2.553" "1235.2" "1305.3" "1212.9" "1197.6" "1288.2" "1147.2" "1297.0" "1244.8" "1197.3" "3153.5" "" "" "" "" "" "" "" "" "" "" "1110.6" "1056.2" "1097.1" "1169.0" "1063.0" "1147.2" "971.1" "1099.5" "1071.3" "1125.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3782870004774892945" "False" "High" "IsMasterProtein" "Q15796" "Mothers against decapentaplegic homolog 2 OS=Homo sapiens OX=9606 GN=SMAD2 PE=1 SV=1" "0.000" "False" "49.195" "27" "11" "18" "6" "467" "52.3" "6.58" "62.79" "11" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4087" "ENSG00000175387" "SMAD2" "hsa:4087; Q15796" "Cell cycle; AGE/RAGE pathway; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Tgif disruption of Shh signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; LDLRAD4 and what we know about it; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; GDNF signaling; Inflammatory bowel disease signaling; Macrophage-stimulating protein (MSP) signaling network map; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; Transcriptional regulation of pluripotent stem cells; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "49" "3" "1.060" "1.023" "0.954" "1.077" "1.005" "1.044" "1.025" "1.025" "1.042" "889.7" "942.8" "910.5" "848.8" "958.5" "893.7" "929.1" "911.7" "912.1" "926.7" "" "" "" "" "" "" "" "" "" "" "799.9" "762.9" "823.6" "828.5" "791.0" "893.7" "695.7" "805.3" "816.1" "330.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062683060595135562" "False" "High" "IsMasterProtein" "Q9NVE7" "4'-phosphopantetheine phosphatase OS=Homo sapiens OX=9606 GN=PANK4 PE=1 SV=1" "0.000" "False" "49.182" "20" "13" "17" "13" "773" "85.9" "6.28" "60.59" "13" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01937, Pf03630" "55229" "ENSG00000157881; ENSG00000273494" "PANK4" "B9DI84; hsa:55229; Q53EU3; Q5TA84; Q7RTX3; Q9H3X5; Q9NVE7" "1p36 copy number variation syndrome" "Vitamin B5 (pantothenate) metabolism" "2" "0" "1.013" "1.027" "0.981" "1.011" "0.983" "0.939" "0.969" "0.978" "0.895" "856.6" "867.8" "879.8" "840.3" "866.3" "842.4" "804.7" "830.4" "837.7" "766.3" "" "" "" "" "" "" "" "" "" "" "770.2" "702.2" "795.8" "820.2" "714.9" "842.4" "602.5" "733.5" "749.6" "273.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6380773280211833227" "False" "High" "IsMasterProtein" "Q9Y508" "E3 ubiquitin-protein ligase RNF114 OS=Homo sapiens OX=9606 GN=RNF114 PE=1 SV=1" "0.000" "False" "49.168" "50" "8" "20" "8" "228" "25.7" "7.25" "75.50" "8" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf05605, Pf13445, Pf18574" "55905" "ENSG00000124226" "RNF114" "B2RDQ9; B4DWY5; E1P627; hsa:55905; Q6N0B0; Q9Y508" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.878" "0.988" "0.947" "0.992" "0.969" "0.944" "0.937" "0.984" "0.939" "1120.9" "984.4" "1107.4" "1061.5" "1112.3" "1085.8" "1058.0" "1050.0" "1102.8" "1053.0" "" "" "" "" "" "" "" "" "" "" "1007.8" "796.6" "1001.7" "1036.2" "917.9" "1085.8" "792.2" "927.4" "986.8" "375.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8984223167418137130" "False" "High" "IsMasterProtein" "P62633" "CCHC-type zinc finger nucleic acid binding protein OS=Homo sapiens OX=9606 GN=CNBP PE=1 SV=1" "0.000" "False" "49.167" "58" "9" "36" "9" "177" "19.5" "7.71" "121.42" "9" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "7555" "ENSG00000169714" "CNBP" "A8K7V4; B2RAV9; B4DP17; D3DNB9; D3DNC0; D3DNC1; E9PDR7; hsa:7555; P20694; P62633; Q4JGY0; Q4JGY1; Q5QJR0; Q5U0E9; Q6PJI7; Q96NV3" "" "SARS-CoV-2 activates/modulates innate and adaptive immune responses" "1" "0" "0.951" "0.892" "0.928" "0.947" "0.883" "0.954" "1.001" "0.962" "0.777" "1483.7" "1410.7" "1324.1" "1377.5" "1404.7" "1310.6" "1416.0" "1484.7" "1427.3" "1152.9" "" "" "" "" "" "" "" "" "" "" "1334.0" "1141.5" "1197.7" "1344.6" "1159.2" "1310.6" "1060.3" "1311.4" "1277.1" "411.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2088218542987526353" "False" "High" "IsMasterProtein" "P49005" "DNA polymerase delta subunit 2 OS=Homo sapiens OX=9606 GN=POLD2 PE=1 SV=1" "0.000" "False" "49.163" "32" "12" "18" "12" "469" "51.3" "5.58" "69.97" "12" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity" "Pf04042, Pf18018" "5425" "ENSG00000106628" "POLD2" "A4D2J4; B2R5S4; hsa:5425; P49005" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Polymerase switching on the C-strand of the telomere; Polymerase switching" "25" "0" "1.063" "0.962" "0.993" "1.097" "0.907" "1.117" "1.051" "0.978" "1.060" "1265.4" "1344.9" "1217.0" "1256.9" "1388.7" "1147.9" "1413.8" "1330.2" "1237.6" "1341.9" "" "" "" "" "" "" "" "" "" "" "1137.8" "1088.3" "1100.9" "1226.9" "1145.9" "1147.9" "1058.6" "1174.9" "1107.4" "479.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1708640290626267049" "False" "High" "IsMasterProtein" "P37108" "Signal recognition particle 14 kDa protein OS=Homo sapiens OX=9606 GN=SRP14 PE=1 SV=2" "0.000" "False" "49.151" "38" "8" "24" "8" "136" "14.6" "10.04" "86.65" "8" "other biological processes" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02290" "6727" "ENSG00000140319" "SRP14" "B5BUF5; hsa:6727; P37108; Q6B0K5; Q96Q14" "" "Neutrophil degranulation; SRP-dependent cotranslational protein targeting to membrane" "2" "0" "0.905" "0.998" "1.012" "0.925" "1.044" "0.961" "0.992" "1.002" "0.693" "4645.0" "4203.6" "4634.0" "4701.2" "4297.5" "4848.8" "4462.9" "4608.7" "4653.2" "3220.6" "" "" "" "" "" "" "" "" "" "" "4176.3" "3401.4" "4191.6" "4589.0" "3546.4" "4848.8" "3341.7" "4070.7" "4163.6" "1149.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6704752873658697689" "False" "High" "IsMasterProtein" "P37268" "Squalene synthase OS=Homo sapiens OX=9606 GN=FDFT1 PE=1 SV=1" "0.000" "False" "49.120" "32" "11" "18" "11" "417" "48.1" "6.54" "64.13" "11" "other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00494" "2222" "ENSG00000079459; ENSG00000284967" "FDFT1" "B3KQ95; B4DJE5; B4DT56; B7Z1J3; hsa:2222; P37268; Q96GT0" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; Ferroptosis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism; 8p23.1 copy number variation syndrome" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "12" "0" "0.945" "1.005" "1.079" "1.109" "1.006" "0.956" "1.010" "1.056" "0.871" "1324.1" "1250.9" "1331.4" "1428.4" "1469.1" "1332.3" "1266.5" "1338.0" "1398.6" "1153.6" "" "" "" "" "" "" "" "" "" "" "1190.5" "1012.2" "1204.3" "1394.3" "1212.3" "1332.3" "948.3" "1181.8" "1251.5" "411.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2304396321486536577" "False" "High" "IsMasterProtein" "Q8IXQ4" "GPALPP motifs-containing protein 1 OS=Homo sapiens OX=9606 GN=GPALPP1 PE=1 SV=1" "0.000" "False" "49.116" "39" "11" "17" "11" "340" "38.1" "5.41" "67.51" "11" "" "" "" "Pf12572" "55425" "ENSG00000133114" "GPALPP1" "A8K8X8; hsa:55425; Q05BX8; Q05D87; Q5T3Z3; Q5T3Z5; Q8IXQ4; Q9C0F9; Q9H2R0; Q9P0W6" "" "" "0" "0" "0.895" "0.939" "0.978" "0.908" "0.939" "0.885" "0.967" "0.960" "0.775" "1611.3" "1441.3" "1512.9" "1576.6" "1463.5" "1512.6" "1426.6" "1557.5" "1546.7" "1249.0" "" "" "" "" "" "" "" "" "" "" "1448.7" "1166.3" "1368.5" "1539.0" "1207.7" "1512.6" "1068.2" "1375.7" "1384.0" "445.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8818107332528144144" "False" "High" "IsMasterProtein" "Q9H4E7" "Differentially expressed in FDCP 6 homolog OS=Homo sapiens OX=9606 GN=DEF6 PE=1 SV=1" "0.000" "False" "49.102" "17" "11" "15" "11" "631" "73.9" "6.05" "55.04" "11" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00169" "50619" "ENSG00000023892" "DEF6" "hsa:50619; Q86VF4; Q9H4E7" "" "CDC42 GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle" "4" "0" "1.072" "1.088" "0.988" "1.077" "1.159" "1.109" "1.043" "1.147" "4.346" "1159.9" "1243.2" "1262.3" "1146.2" "1248.7" "1343.8" "1286.6" "1209.3" "1330.8" "5040.8" "" "" "" "" "" "" "" "" "" "" "1042.9" "1005.9" "1141.8" "1118.9" "1030.4" "1343.8" "963.4" "1068.1" "1190.8" "1799.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2857218708684993243" "False" "High" "IsMasterProtein" "Q9Y315" "Deoxyribose-phosphate aldolase OS=Homo sapiens OX=9606 GN=DERA PE=1 SV=2" "0.000" "False" "49.084" "49" "12" "14" "12" "318" "35.2" "8.94" "54.64" "12" "other metabolic processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf01791" "51071" "ENSG00000023697" "DERA" "hsa:51071; Q53HN9; Q6PHW2; Q9Y315" "Pentose phosphate pathway in senescent cells" "Neutrophil degranulation; Pentose phosphate pathway" "3" "0" "0.983" "0.997" "0.964" "0.989" "0.974" "0.936" "1.023" "1.042" "0.804" "979.5" "963.2" "976.8" "944.1" "968.6" "954.3" "916.7" "1001.8" "1020.7" "787.8" "" "" "" "" "" "" "" "" "" "" "880.6" "779.4" "883.6" "921.6" "799.3" "954.3" "686.4" "884.8" "913.3" "281.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4994086141420822230" "False" "High" "IsMasterProtein" "P02794" "Ferritin heavy chain OS=Homo sapiens OX=9606 GN=FTH1 PE=1 SV=2" "0.000" "False" "49.045" "58" "8" "23" "8" "183" "21.2" "5.55" "91.62" "8" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2495" "ENSG00000167996" "FTH1" "B3KNR5; hsa:2495; P02794; Q3KRA8; Q3SWW1" "Iron metabolism in placenta; Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Iron metabolism disorders" "Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport; Scavenging by Class A Receptors" "9" "0" "0.833" "0.978" "0.946" "0.949" "0.917" "0.907" "0.981" "1.010" "0.750" "2103.3" "1751.1" "2057.9" "1990.2" "1996.5" "1928.0" "1906.9" "2063.6" "2124.1" "1578.2" "" "" "" "" "" "" "" "" "" "" "1891.1" "1416.9" "1861.5" "1942.8" "1647.6" "1928.0" "1427.9" "1822.7" "1900.6" "563.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5750940690254382676" "False" "High" "IsMasterProtein" "P16333" "SH2/SH3 adapter protein NCK1 OS=Homo sapiens OX=9606 GN=NCK1 PE=1 SV=1" "0.000" "False" "49.038" "38" "14" "17" "14" "377" "42.8" "6.47" "57.45" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018" "4690" "ENSG00000158092" "NCK1" "B7Z751; D3DNE3; hsa:4690; P16333" "Pathogenic Escherichia coli infection; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Genes controlling nephrogenesis; GDNF signaling; ErbB signaling pathway; T-cell receptor signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Generation of second messenger molecules; RHO GTPases Activate WASPs and WAVEs; PKR-mediated signaling; RHOV GTPase cycle; RHOU GTPase cycle; Nephrin family interactions; DCC mediated attractive signaling; Downstream signal transduction; VEGFA-VEGFR2 Pathway; Activation of RAC1" "27" "0" "1.132" "1.123" "1.046" "1.101" "1.141" "1.053" "1.037" "1.102" "1.816" "747.3" "845.9" "839.5" "781.8" "822.5" "852.6" "786.8" "774.9" "823.6" "1356.9" "" "" "" "" "" "" "" "" "" "" "671.9" "684.5" "759.3" "763.1" "678.8" "852.6" "589.1" "684.4" "737.0" "484.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3792046426100688845" "False" "High" "IsMasterProtein" "O43395" "U4/U6 small nuclear ribonucleoprotein Prp3 OS=Homo sapiens OX=9606 GN=PRPF3 PE=1 SV=2" "0.000" "False" "48.984" "23" "14" "16" "14" "683" "77.5" "9.50" "55.16" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01480, Pf06544, Pf08572" "9129" "ENSG00000117360" "PRPF3" "B4DSY9; hsa:9129; O43395; O43446; Q5VT54" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.991" "0.889" "1.005" "1.032" "1.008" "1.004" "0.984" "0.893" "1.260" "1396.0" "1383.5" "1240.9" "1402.8" "1440.1" "1407.1" "1401.4" "1373.4" "1246.3" "1758.6" "" "" "" "" "" "" "" "" "" "" "1255.1" "1119.5" "1122.4" "1369.4" "1188.4" "1407.1" "1049.3" "1213.1" "1115.1" "627.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3994856410542386969" "False" "High" "IsMasterProtein" "Q9BW92" "Threonine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=TARS2 PE=1 SV=1" "0.000" "False" "48.980" "18" "11" "14" "11" "718" "81.0" "7.30" "55.71" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00587, Pf02824, Pf03129, Pf07973" "80222" "ENSG00000143374" "TARS2" "hsa:80222; Q53GW7; Q96I50; Q9BW92; Q9H9V2" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.090" "0.961" "1.011" "1.080" "0.994" "1.087" "1.063" "0.948" "1.062" "1082.6" "1180.1" "1040.8" "1094.4" "1169.4" "1075.9" "1177.1" "1150.3" "1026.0" "1149.3" "" "" "" "" "" "" "" "" "" "" "973.4" "954.9" "941.4" "1068.3" "965.0" "1075.9" "881.4" "1016.0" "918.0" "410.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2548334964560567831" "False" "High" "IsMasterProtein" "Q9GZT8" "NIF3-like protein 1 OS=Homo sapiens OX=9606 GN=NIF3L1 PE=1 SV=2" "0.000" "False" "48.977" "28" "12" "22" "12" "377" "41.9" "6.65" "72.58" "12" "developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01784" "60491" "ENSG00000196290" "NIF3L1" "hsa:60491; Q53TX4; Q6X735; Q9GZT8; Q9H2D2; Q9HC18" "" "" "0" "0" "1.052" "1.025" "0.978" "1.087" "0.977" "1.044" "1.026" "1.018" "0.811" "1479.5" "1555.9" "1516.9" "1446.6" "1608.4" "1445.2" "1544.1" "1518.7" "1505.4" "1199.5" "" "" "" "" "" "" "" "" "" "" "1330.2" "1259.0" "1372.1" "1412.1" "1327.3" "1445.2" "1156.2" "1341.4" "1347.0" "428.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327789120096563661" "False" "High" "IsMasterProtein" "Q9NR56" "Muscleblind-like protein 1 OS=Homo sapiens OX=9606 GN=MBNL1 PE=1 SV=2" "0.000" "False" "48.930" "35" "10" "19" "5" "388" "41.8" "8.90" "77.30" "10" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "4154" "ENSG00000152601" "MBNL1" "E9PBW7; hsa:4154; O43311; O43797; Q86UV8; Q86UV9; Q96P92; Q96RE3; Q9NR56" "Adipogenesis" "" "1" "5" "0.975" "0.967" "0.964" "0.985" "0.968" "0.967" "1.043" "0.951" "0.849" "2493.3" "2432.2" "2411.5" "2403.5" "2456.0" "2413.6" "2411.0" "2600.4" "2370.3" "2117.1" "" "" "" "" "" "" "" "" "" "" "2241.7" "1968.0" "2181.3" "2346.2" "2026.7" "2413.6" "1805.3" "2296.8" "2120.9" "755.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7101780835120275737" "False" "High" "IsMasterProtein" "Q9Y3Q8" "TSC22 domain family protein 4 OS=Homo sapiens OX=9606 GN=TSC22D4 PE=1 SV=2" "0.000" "False" "48.894" "36" "11" "15" "9" "395" "41.0" "7.21" "56.56" "11" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf01166" "81628" "ENSG00000166925" "TSC22D4" "A4D2C3; A8MWR6; D6W5V9; hsa:81628; Q9Y3Q8" "" "" "0" "1" "0.970" "1.008" "1.035" "1.032" "0.993" "1.079" "1.045" "1.020" "1.176" "882.3" "856.2" "889.0" "913.5" "910.7" "875.8" "952.0" "922.4" "900.1" "1037.8" "" "" "" "" "" "" "" "" "" "" "793.3" "692.8" "804.1" "891.7" "751.6" "875.8" "712.8" "814.7" "805.4" "370.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4306036841848923980" "False" "High" "IsMasterProtein" "Q08752" "Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens OX=9606 GN=PPID PE=1 SV=3" "0.000" "False" "48.889" "35" "13" "20" "12" "370" "40.7" "7.21" "64.03" "13" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "5481" "ENSG00000171497" "PPID" "B2R9V2; hsa:5481; Q08752" "Alzheimer's disease and miRNA effects; NO/cGMP/PKG mediated neuroprotection; Alzheimer's disease" "ESR-mediated signaling" "4" "0" "0.976" "1.033" "0.976" "0.994" "0.975" "0.980" "0.970" "0.977" "1.967" "1540.2" "1503.1" "1590.7" "1502.7" "1530.2" "1502.1" "1508.9" "1493.8" "1504.7" "3030.2" "" "" "" "" "" "" "" "" "" "" "1384.8" "1216.2" "1438.9" "1466.9" "1262.8" "1502.1" "1129.8" "1319.4" "1346.4" "1081.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2904127799800100027" "False" "High" "IsMasterProtein" "Q8IYS1" "Xaa-Arg dipeptidase OS=Homo sapiens OX=9606 GN=PM20D2 PE=1 SV=2" "0.000" "False" "48.883" "30" "11" "19" "11" "436" "47.7" "5.85" "71.92" "11" "protein metabolism;other biological processes" "nucleus" "other molecular function" "Pf01546, Pf07687" "135293" "ENSG00000146281" "PM20D2" "B4DYJ2; hsa:135293; Q5T7J9; Q6MZV2; Q86XD9; Q8IYS1" "" "" "0" "0" "0.959" "1.028" "1.112" "1.024" "0.993" "1.144" "0.942" "0.931" "2.213" "1281.6" "1229.2" "1317.6" "1425.3" "1312.4" "1273.3" "1466.3" "1207.4" "1192.6" "2835.7" "" "" "" "" "" "" "" "" "" "" "1152.3" "994.6" "1191.9" "1391.3" "1083.0" "1273.3" "1097.9" "1066.4" "1067.1" "1012.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926098929249154387" "False" "High" "IsMasterProtein" "Q9NR28" "Diablo IAP-binding mitochondrial protein OS=Homo sapiens OX=9606 GN=DIABLO PE=1 SV=1" "0.000" "False" "48.863" "35" "9" "19" "9" "239" "27.1" "5.90" "71.91" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf09057" "56616" "ENSG00000184047" "DIABLO" "B2RDQ0; hsa:56616; Q6W3F3; Q96LV0; Q9BT11; Q9HAV6; Q9NR28" "Apoptosis modulation and signaling; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Apoptosis; Complement system in neuronal development and plasticity" "SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Release of apoptotic factors from the mitochondria" "10" "0" "0.893" "0.957" "0.974" "0.991" "0.934" "0.983" "0.966" "1.016" "0.803" "1823.7" "1628.1" "1746.1" "1775.6" "1807.4" "1703.9" "1792.5" "1762.4" "1853.2" "1465.1" "" "" "" "" "" "" "" "" "" "" "1639.7" "1317.4" "1579.4" "1733.3" "1491.5" "1703.9" "1342.1" "1556.7" "1658.2" "523.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3968134916858178565" "False" "High" "IsMasterProtein" "P61247" "Small ribosomal subunit protein eS1 OS=Homo sapiens OX=9606 GN=RPS3A PE=1 SV=2" "0.000" "False" "48.848" "48" "12" "21" "12" "264" "29.9" "9.73" "74.07" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01015" "6189" "ENSG00000145425; ENSG00000292158" "RPS3A" "B2R4D4; D3DP05; hsa:6189; P33443; P49241; P61247" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.898" "0.923" "0.891" "0.901" "0.979" "0.948" "0.888" "0.932" "1.178" "1998.0" "1793.5" "1844.9" "1781.1" "1799.9" "1955.3" "1895.0" "1773.3" "1863.1" "2352.8" "" "" "" "" "" "" "" "" "" "" "1796.4" "1451.2" "1668.8" "1738.6" "1485.3" "1955.3" "1419.0" "1566.3" "1667.1" "839.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6782447041087316008" "False" "High" "IsMasterProtein" "Q9UNF0" "Protein kinase C and casein kinase substrate in neurons protein 2 OS=Homo sapiens OX=9606 GN=PACSIN2 PE=1 SV=2" "0.000" "False" "48.837" "30" "13" "23" "13" "486" "55.7" "5.20" "70.88" "13" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00611, Pf14604" "11252" "ENSG00000100266" "PACSIN2" "hsa:11252; O95921; Q96HV9; Q9H0D3; Q9NPN1; Q9UNF0; Q9Y4V2" "" "Clathrin-mediated endocytosis" "1" "0" "0.883" "0.902" "1.000" "0.842" "0.807" "0.993" "0.797" "0.802" "1.709" "2286.3" "2019.0" "2061.4" "2285.7" "1924.3" "1845.2" "2270.6" "1821.9" "1833.1" "3907.5" "" "" "" "" "" "" "" "" "" "" "2055.7" "1633.7" "1864.6" "2231.1" "1588.0" "1845.2" "1700.2" "1609.2" "1640.3" "1394.9" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9007113237130658680" "False" "High" "IsMasterProtein" "O15498" "Synaptobrevin homolog YKT6 OS=Homo sapiens OX=9606 GN=YKT6 PE=1 SV=1" "0.000" "False" "48.835" "55" "10" "19" "10" "198" "22.4" "6.92" "78.26" "10" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "10652" "ENSG00000106636" "YKT6" "B4DR94; hsa:10652; O15498; Q53F01; Q6FGU9; Q6IB15" "" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; COPI-mediated anterograde transport; RAC3 GTPase cycle; Intra-Golgi traffic; COPII-mediated vesicle transport" "8" "0" "1.010" "1.004" "0.933" "1.007" "0.893" "1.014" "0.983" "0.980" "0.748" "1584.3" "1600.3" "1590.5" "1478.6" "1594.8" "1414.5" "1607.0" "1557.5" "1552.2" "1184.5" "" "" "" "" "" "" "" "" "" "" "1424.4" "1294.9" "1438.7" "1443.3" "1316.1" "1414.5" "1203.3" "1375.7" "1388.9" "422.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6271968905262141895" "False" "High" "IsMasterProtein" "Q4VC31" "Protein MIX23 OS=Homo sapiens OX=9606 GN=MIX23 PE=1 SV=1" "0.000" "False" "48.805" "56" "7" "20" "7" "144" "16.6" "7.81" "81.23" "7" "" "mitochondrion" "" "Pf09774" "131076" "ENSG00000160124" "MIX23" "hsa:131076; Q32LY6; Q4VC31" "" "" "0" "0" "0.967" "0.965" "0.932" "0.984" "0.916" "1.019" "1.016" "0.956" "0.743" "2622.4" "2535.7" "2530.0" "2444.6" "2581.5" "2403.1" "2672.4" "2665.1" "2507.4" "1948.0" "" "" "" "" "" "" "" "" "" "" "2357.8" "2051.8" "2288.5" "2386.2" "2130.3" "2403.1" "2001.0" "2353.9" "2243.6" "695.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3793795971274937654" "False" "High" "IsMasterProtein" "Q96S59" "Ran-binding protein 9 OS=Homo sapiens OX=9606 GN=RANBP9 PE=1 SV=1" "0.000" "False" "48.796" "15" "8" "14" "8" "729" "77.8" "6.79" "50.52" "8" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00622, Pf08513, Pf10607" "10048" "ENSG00000010017" "RANBP9" "A0PJA2; B2R8E1; hsa:10048; O94764; Q6P3T7; Q7LBR2; Q7Z7F9; Q96S59" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Ciliary landscape" "RAF/MAP kinase cascade; L1CAM interactions; MET activates RAS signaling" "5" "0" "1.060" "1.115" "0.963" "1.034" "1.068" "0.980" "1.030" "1.071" "0.853" "937.4" "993.3" "1045.0" "903.1" "969.1" "1000.8" "918.7" "965.1" "1003.9" "799.6" "" "" "" "" "" "" "" "" "" "" "842.8" "803.7" "945.2" "881.6" "799.7" "1000.8" "687.9" "852.4" "898.3" "285.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3259776130493618651" "False" "High" "IsMasterProtein" "Q6PI48" "Aspartate--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=DARS2 PE=1 SV=1" "0.000" "False" "48.794" "23" "13" "16" "13" "645" "73.5" "8.02" "60.87" "13" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336, Pf02938" "55157" "ENSG00000117593" "DARS2" "hsa:55157; Q6PI48" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.071" "1.073" "0.993" "1.099" "1.078" "1.002" "1.075" "1.136" "0.900" "1221.6" "1308.5" "1310.6" "1213.4" "1343.1" "1317.1" "1223.6" "1313.2" "1387.6" "1100.0" "" "" "" "" "" "" "" "" "" "" "1098.3" "1058.8" "1185.5" "1184.4" "1108.4" "1317.1" "916.2" "1159.9" "1241.6" "392.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6945972540220555835" "False" "High" "IsMasterProtein" "Q96ST3" "Paired amphipathic helix protein Sin3a OS=Homo sapiens OX=9606 GN=SIN3A PE=1 SV=2" "0.000" "False" "48.756" "12" "13" "15" "13" "1273" "145.1" "7.25" "46.45" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02671, Pf08295, Pf16879" "25942" "ENSG00000169375" "SIN3A" "B2RNS5; Q8N8N4; Q8NC83; Q8WV18; Q96L98; Q96ST3; Q9UFQ1" "Androgen receptor signaling pathway; Retinoblastoma gene in cancer; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; Hedgehog signaling pathway; 15q11q13 copy number variation" "Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; NoRC negatively regulates rRNA expression; STAT3 nuclear events downstream of ALK signaling; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SUMOylation of transcription cofactors; MECP2 regulates transcription of neuronal ligands; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Regulation of lipid metabolism by PPARalpha; Regulation of MECP2 expression and activity; MECP2 regulates neuronal receptors and channels; Loss of MECP2 binding ability to 5mC-DNA" "19" "0" "0.976" "0.943" "1.008" "0.968" "0.928" "1.013" "0.944" "0.949" "1.387" "615.5" "600.5" "580.4" "620.7" "595.7" "571.2" "623.8" "580.9" "583.8" "853.9" "" "" "" "" "" "" "" "" "" "" "553.4" "485.9" "525.0" "605.9" "491.6" "571.2" "467.0" "513.1" "522.4" "304.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4653311583040189549" "False" "High" "IsMasterProtein" "Q9H2P9" "Diphthine methyl ester synthase OS=Homo sapiens OX=9606 GN=DPH5 PE=1 SV=2" "0.000" "False" "48.752" "36" "10" "15" "10" "285" "31.6" "5.31" "76.18" "10" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00590" "51611" "ENSG00000117543" "DPH5" "A8JZY6; D3DT62; hsa:51611; Q9H2P9; Q9P017; Q9P0I4; Q9Y319" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.019" "0.991" "0.956" "1.038" "0.987" "0.965" "0.986" "1.026" "0.831" "1468.5" "1496.6" "1456.0" "1403.3" "1524.2" "1448.8" "1416.8" "1448.2" "1506.6" "1220.8" "" "" "" "" "" "" "" "" "" "" "1320.3" "1211.0" "1317.0" "1369.8" "1257.8" "1448.8" "1060.8" "1279.1" "1348.1" "435.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2558659697255910600" "False" "High" "IsMasterProtein" "Q92747" "Actin-related protein 2/3 complex subunit 1A OS=Homo sapiens OX=9606 GN=ARPC1A PE=1 SV=2" "0.000" "False" "48.744" "41" "12" "16" "11" "370" "41.5" "8.18" "63.21" "12" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00400" "10552" "ENSG00000241685" "ARPC1A" "A4D276; B4DLQ7; D6W5S1; hsa:10552; Q7Z5U8; Q86WU5; Q8IXQ0; Q92747" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Clathrin-mediated endocytosis; RHO GTPases Activate WASPs and WAVEs; EPHB-mediated forward signaling" "6" "0" "0.987" "0.968" "0.981" "1.034" "0.999" "1.024" "0.987" "1.059" "0.777" "1215.9" "1199.7" "1176.9" "1192.5" "1257.7" "1214.9" "1245.3" "1200.0" "1287.5" "944.9" "" "" "" "" "" "" "" "" "" "" "1093.2" "970.8" "1064.5" "1164.1" "1037.9" "1214.9" "932.4" "1059.9" "1152.0" "337.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238479499176412626" "False" "High" "IsMasterProtein" "O60828" "Polyglutamine-binding protein 1 OS=Homo sapiens OX=9606 GN=PQBP1 PE=1 SV=1" "0.000" "False" "48.737" "32" "8" "15" "8" "265" "30.5" "6.33" "54.88" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "10084" "ENSG00000102103; ENSG00000292208" "PQBP1" "C9JQA1; hsa:10084; O60828; Q4VY25; Q4VY26; Q4VY27; Q4VY29; Q4VY30; Q4VY34; Q4VY35; Q4VY36; Q4VY37; Q4VY38; Q9GZP2; Q9GZU4; Q9GZZ4" "" "mRNA Splicing - Major Pathway" "1" "0" "1.066" "1.074" "1.058" "1.032" "1.097" "0.936" "1.142" "1.050" "0.869" "758.8" "809.0" "815.3" "803.2" "783.4" "832.7" "709.9" "866.3" "796.8" "659.1" "" "" "" "" "" "" "" "" "" "" "682.3" "654.6" "737.4" "784.1" "646.5" "832.7" "531.6" "765.2" "713.0" "235.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2863197479310684416" "False" "High" "IsMasterProtein" "Q96EK6" "Glucosamine 6-phosphate N-acetyltransferase OS=Homo sapiens OX=9606 GN=GNPNAT1 PE=1 SV=1" "0.000" "False" "48.677" "48" "7" "16" "7" "184" "20.7" "7.99" "60.10" "7" "other metabolic processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00583" "64841" "ENSG00000100522" "GNPNAT1" "hsa:64841; Q96EK6" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.026" "1.085" "1.018" "1.099" "1.089" "1.056" "1.032" "1.092" "0.821" "1433.4" "1470.7" "1556.0" "1459.7" "1575.3" "1561.1" "1513.2" "1479.0" "1565.4" "1176.7" "" "" "" "" "" "" "" "" "" "" "1288.8" "1190.0" "1407.4" "1424.8" "1300.0" "1561.1" "1133.0" "1306.3" "1400.7" "420.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835883825689200365" "False" "High" "IsMasterProtein" "Q92979" "Ribosomal RNA small subunit methyltransferase NEP1 OS=Homo sapiens OX=9606 GN=EMG1 PE=1 SV=4" "0.000" "False" "48.674" "45" "9" "17" "9" "244" "26.7" "9.17" "64.65" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03587" "10436" "ENSG00000126749" "EMG1" "hsa:10436; O00675; O00726; Q92979" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.951" "1.013" "0.920" "0.953" "1.011" "0.920" "0.849" "0.951" "0.669" "1887.0" "1793.9" "1911.9" "1736.6" "1798.6" "1908.4" "1737.0" "1601.7" "1794.0" "1263.2" "" "" "" "" "" "" "" "" "" "" "1696.6" "1451.6" "1729.4" "1695.2" "1484.2" "1908.4" "1300.6" "1414.7" "1605.3" "450.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7018160903413407228" "False" "High" "IsMasterProtein" "Q9BW85" "Splicing factor YJU2 OS=Homo sapiens OX=9606 GN=YJU2 PE=1 SV=1" "0.000" "False" "48.577" "33" "8" "22" "8" "323" "37.1" "5.92" "101.00" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf04502" "55702" "ENSG00000105248" "YJU2" "hsa:55702; O75270; Q9BW85; Q9H862; Q9NW16" "" "mRNA Splicing - Major Pathway" "1" "0" "0.992" "1.000" "1.055" "1.089" "0.977" "1.025" "1.066" "1.058" "1.004" "1464.4" "1453.1" "1463.8" "1545.0" "1594.2" "1430.2" "1501.5" "1560.4" "1549.4" "1470.7" "" "" "" "" "" "" "" "" "" "" "1316.7" "1175.8" "1324.0" "1508.2" "1315.6" "1430.2" "1124.3" "1378.2" "1386.4" "525.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3676501743634657271" "False" "High" "IsMasterProtein" "P40855" "Peroxisomal biogenesis factor 19 OS=Homo sapiens OX=9606 GN=PEX19 PE=1 SV=1" "0.000" "False" "48.534" "37" "9" "17" "9" "299" "32.8" "4.34" "61.45" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04614" "5824" "ENSG00000162735" "PEX19" "D3DVE7; E9PPB4; G3V3G9; hsa:5824; P40855; Q5QNY4; Q8NI97" "TAR syndrome" "Class I peroxisomal membrane protein import; ABC transporters in lipid homeostasis" "3" "0" "0.947" "1.012" "0.957" "1.035" "1.024" "1.028" "1.034" "0.987" "0.776" "1264.0" "1196.7" "1279.0" "1209.1" "1307.6" "1294.4" "1299.9" "1307.4" "1247.0" "980.9" "" "" "" "" "" "" "" "" "" "" "1136.4" "968.3" "1156.9" "1180.2" "1079.1" "1294.4" "973.3" "1154.8" "1115.8" "350.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8429981221702182893" "False" "High" "IsMasterProtein" "P20340" "Ras-related protein Rab-6A OS=Homo sapiens OX=9606 GN=RAB6A PE=1 SV=3" "0.000" "False" "48.525" "46" "8" "26" "6" "208" "23.6" "5.54" "81.56" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5870" "ENSG00000175582" "RAB6A" "A8K133; B7Z772; F5H668; hsa:5870; P20340; Q1W5D8; Q5U0A8; Q9UBE4" "" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; COPI-independent Golgi-to-ER retrograde traffic; Pre-NOTCH Processing in Golgi; Retrograde transport at the Trans-Golgi-Network; TBC/RABGAPs" "7" "0" "1.044" "1.162" "1.090" "1.127" "1.099" "1.125" "1.075" "1.131" "0.908" "988.8" "1032.1" "1149.0" "1078.1" "1114.3" "1086.7" "1112.4" "1063.0" "1118.0" "897.4" "" "" "" "" "" "" "" "" "" "" "889.0" "835.2" "1039.3" "1052.4" "919.5" "1086.7" "832.9" "938.9" "1000.4" "320.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500011476613652918" "False" "High" "IsMasterProtein" "Q92526" "T-complex protein 1 subunit zeta-2 OS=Homo sapiens OX=9606 GN=CCT6B PE=1 SV=5" "0.000" "False" "48.470" "15" "7" "26" "1" "530" "57.8" "7.24" "90.11" "7" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00118" "10693" "ENSG00000132141" "CCT6B" "B4DX20; B4DYB0; hsa:10693; Q8TC34; Q92526" "16p11.2 proximal deletion syndrome; 17q12 copy number variation syndrome" "Formation of tubulin folding intermediates by CCT/TriC; Association of TriC/CCT with target proteins during biosynthesis; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; Prefoldin mediated transfer of substrate to CCT/TriC; Folding of actin by CCT/TriC" "7" "0" "0.958" "1.000" "0.983" "1.026" "0.943" "0.873" "0.868" "0.956" "0.859" "117.3" "112.4" "117.3" "115.3" "120.3" "110.5" "102.4" "101.7" "112.1" "100.7" "" "" "" "" "" "" "" "" "" "" "105.4" "90.9" "106.1" "112.5" "99.3" "110.5" "76.6" "89.9" "100.3" "35.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8717511238945883438" "False" "High" "IsMasterProtein" "Q12769" "Nuclear pore complex protein Nup160 OS=Homo sapiens OX=9606 GN=NUP160 PE=1 SV=3" "0.000" "False" "48.451" "11" "14" "17" "14" "1436" "162.0" "5.50" "57.62" "14" "other metabolic processes;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf11715" "23279" "ENSG00000030066" "NUP160" "B4DYE8; B4E2J9; hsa:23279; Q08AD3; Q12769; Q7Z5X6; Q96GB3; Q9H660" "" "SUMOylation of DNA replication proteins; Rev-mediated nuclear export of HIV RNA; Nuclear import of Rev protein; Postmitotic nuclear pore complex (NPC) reformation; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "35" "0" "1.031" "0.983" "0.921" "1.031" "1.010" "1.001" "0.955" "0.983" "1.004" "1594.2" "1643.5" "1567.6" "1468.8" "1643.1" "1610.7" "1595.5" "1522.0" "1566.8" "1600.5" "" "" "" "" "" "" "" "" "" "" "1433.3" "1329.9" "1418.0" "1433.8" "1355.9" "1610.7" "1194.7" "1344.3" "1402.0" "571.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945585302651271031" "False" "High" "IsMasterProtein" "P43243" "Matrin-3 OS=Homo sapiens OX=9606 GN=MATR3 PE=1 SV=2" "0.000" "False" "48.451" "20" "14" "18" "14" "847" "94.6" "6.25" "58.59" "14" "stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "" "9782" "ENSG00000015479" "MATR3" "B7ZAV5; D3DQC3; hsa:9782; P43243; Q9UHW0; Q9UQ27" "" "" "0" "0" "0.997" "0.941" "1.026" "0.928" "0.960" "0.987" "0.786" "0.907" "8.133" "959.1" "956.2" "902.2" "984.2" "889.7" "920.8" "946.6" "753.8" "870.0" "7800.2" "" "" "" "" "" "" "" "" "" "" "862.3" "773.7" "816.0" "960.7" "734.2" "920.8" "708.8" "665.8" "778.4" "2784.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622169396848351928" "False" "High" "IsMasterProtein" "Q8NFF5" "FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1" "0.000" "False" "48.422" "25" "14" "17" "14" "587" "65.2" "6.93" "54.52" "14" "other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "other molecular function" "Pf00994, Pf01507" "80308" "ENSG00000160688" "FLAD1" "hsa:80308; Q8N5J1; Q8N686; Q8NFF5; Q8WU93; Q8WUJ4; Q96CR8; Q99764; Q9HBN6" "Selenium micronutrient network; Folate metabolism" "Vitamin B2 (riboflavin) metabolism" "3" "0" "1.039" "1.008" "1.025" "1.043" "1.032" "1.042" "1.002" "1.073" "1.082" "1671.6" "1736.4" "1685.4" "1712.7" "1744.1" "1725.8" "1742.6" "1674.7" "1793.5" "1808.8" "" "" "" "" "" "" "" "" "" "" "1502.9" "1405.0" "1524.5" "1671.8" "1439.3" "1725.8" "1304.8" "1479.2" "1604.8" "645.7" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6090359432096684388" "False" "High" "IsMasterProtein" "Q8NCN5" "Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Homo sapiens OX=9606 GN=PDPR PE=1 SV=2" "0.000" "False" "48.382" "16" "12" "15" "12" "879" "99.3" "6.35" "52.38" "12" "" "mitochondrion;other cell component" "other molecular function" "Pf01266, Pf01571, Pf08669, Pf16350" "55066" "ENSG00000090857" "PDPR" "A7E298; A8K8Y7; B3KSE1; Q6AI20; Q6AWC9; Q8NCN5" "" "Regulation of pyruvate dehydrogenase (PDH) complex" "1" "0" "1.084" "1.051" "1.004" "1.124" "1.017" "1.027" "1.006" "1.082" "0.824" "1250.7" "1355.8" "1313.9" "1255.8" "1405.8" "1272.3" "1284.0" "1257.7" "1353.5" "1030.2" "" "" "" "" "" "" "" "" "" "" "1124.5" "1097.1" "1188.5" "1225.8" "1160.1" "1272.3" "961.4" "1110.9" "1211.1" "367.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5779519367271372583" "False" "High" "IsMasterProtein" "Q15645" "Pachytene checkpoint protein 2 homolog OS=Homo sapiens OX=9606 GN=TRIP13 PE=1 SV=2" "0.000" "False" "48.373" "29" "11" "13" "11" "432" "48.5" "6.09" "54.13" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00004" "9319" "ENSG00000071539" "TRIP13" "C9K0T3; D3DTC0; hsa:9319; O15324; Q15645" "Male infertility" "" "1" "0" "1.125" "1.187" "1.026" "1.121" "1.206" "1.144" "1.067" "1.201" "1.779" "1024.3" "1152.4" "1215.6" "1050.4" "1148.1" "1235.1" "1171.6" "1092.8" "1230.1" "1822.3" "" "" "" "" "" "" "" "" "" "" "920.9" "932.5" "1099.5" "1025.3" "947.5" "1235.1" "877.3" "965.2" "1100.7" "650.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-775611795353196892" "False" "High" "IsMasterProtein" "Q86XI2" "Condensin-2 complex subunit G2 OS=Homo sapiens OX=9606 GN=NCAPG2 PE=1 SV=1" "0.000" "False" "48.295" "15" "14" "16" "14" "1143" "130.9" "6.87" "59.37" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12422" "54892" "ENSG00000146918" "NCAPG2" "A4D228; hsa:54892; Q7Z3J9; Q86XI2; Q8WUG8; Q9BRX6; Q9H8S2; Q9H9K6" "Mesodermal commitment pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.115" "1.057" "0.901" "1.012" "1.024" "1.073" "0.941" "1.021" "1.213" "1277.7" "1424.5" "1351.0" "1150.8" "1293.6" "1308.8" "1370.5" "1201.7" "1304.3" "1550.1" "" "" "" "" "" "" "" "" "" "" "1148.7" "1152.7" "1222.0" "1123.3" "1067.5" "1308.8" "1026.2" "1061.4" "1167.1" "553.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585419871706527859" "False" "High" "IsMasterProtein" "Q8TDY2" "RB1-inducible coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=RB1CC1 PE=1 SV=3" "0.000" "False" "48.135" "8" "14" "17" "13" "1594" "183.0" "5.41" "56.69" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10377" "9821" "ENSG00000023287" "RB1CC1" "hsa:9821; Q86YR4; Q8TDY2; Q8WVU9; Q92601" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "11" "0" "1.049" "0.893" "0.995" "0.972" "0.986" "0.990" "0.955" "0.935" "1.153" "466.2" "489.0" "416.4" "463.8" "453.1" "459.8" "461.6" "445.4" "436.1" "537.6" "" "" "" "" "" "" "" "" "" "" "419.2" "395.6" "376.7" "452.8" "373.9" "459.8" "345.6" "393.4" "390.3" "191.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8439683798465219975" "False" "High" "IsMasterProtein" "P08621" "U1 small nuclear ribonucleoprotein 70 kDa OS=Homo sapiens OX=9606 GN=SNRNP70 PE=1 SV=2" "0.000" "False" "48.128" "25" "11" "20" "11" "437" "51.5" "9.94" "65.70" "11" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf12220" "6625" "ENSG00000104852" "SNRNP70" "B3KUA3; hsa:6625; P08621; P78493; P78494; Q15364; Q15686; Q15687; Q15689; Q99377; Q9UE45; Q9UE46; Q9UE47; Q9UE48; Q9UFQ6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.970" "0.924" "0.956" "0.976" "0.993" "0.914" "0.921" "0.941" "0.994" "1786.0" "1731.7" "1651.1" "1708.1" "1743.6" "1772.6" "1631.9" "1644.7" "1680.1" "1775.4" "" "" "" "" "" "" "" "" "" "" "1605.8" "1401.2" "1493.5" "1667.3" "1438.8" "1772.6" "1221.9" "1452.7" "1503.4" "633.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7953357218888963531" "False" "High" "IsMasterProtein" "Q3KQU3" "MAP7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MAP7D1 PE=1 SV=1" "0.000" "False" "48.124" "16" "12" "14" "12" "841" "92.8" "10.11" "50.66" "12" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf05672" "55700" "ENSG00000116871" "MAP7D1" "D3DPS4; hsa:55700; Q3KQU3; Q7L8J5; Q8N905; Q8TAK0; Q9HBQ2; Q9NW29; Q9ULN3" "" "" "0" "0" "1.019" "1.038" "1.076" "1.046" "1.182" "1.127" "1.123" "1.185" "0.958" "596.6" "607.8" "619.4" "642.2" "623.9" "705.4" "672.3" "670.2" "707.2" "571.4" "" "" "" "" "" "" "" "" "" "" "536.4" "491.8" "560.2" "626.9" "514.8" "705.4" "503.4" "592.0" "632.8" "204.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4655855300014543961" "False" "High" "IsMasterProtein" "Q06330" "Recombining binding protein suppressor of hairless OS=Homo sapiens OX=9606 GN=RBPJ PE=1 SV=3" "0.000" "False" "48.105" "27" "11" "13" "11" "500" "55.6" "7.18" "47.34" "11" "cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09270, Pf09271, Pf20144" "3516" "ENSG00000168214" "RBPJ" "B4DY22; hsa:3516; Q06330; Q5XKH9; Q6P1N3" "Neural crest differentiation; Notch signaling; Canonical and non-canonical Notch signaling; PTF1A related regulatory pathway; Epithelial to mesenchymal transition in colorectal cancer; Osteoblast differentiation and related diseases; Genetic causes of porto-sinusoidal vascular disease; Notch signaling pathway" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Somitogenesis; Formation of paraxial mesoderm; Pre-NOTCH Transcription and Translation; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "20" "0" "1.077" "1.090" "1.075" "1.193" "1.079" "1.088" "0.996" "1.127" "0.963" "919.7" "990.6" "1002.5" "989.0" "1097.1" "992.2" "1000.5" "916.0" "1036.8" "886.1" "" "" "" "" "" "" "" "" "" "" "826.9" "801.5" "906.8" "965.4" "905.3" "992.2" "749.2" "809.0" "927.8" "316.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3098195104215073585" "False" "High" "IsMasterProtein" "P23919" "Thymidylate kinase OS=Homo sapiens OX=9606 GN=DTYMK PE=1 SV=4" "0.000" "False" "48.037" "45" "10" "19" "10" "212" "23.8" "8.27" "68.88" "10" "other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf02223" "1841" "ENSG00000168393" "DTYMK" "B7ZW70; hsa:1841; P23919; Q6FGX1; Q9BUX4" "Pyrimidine metabolism; 2q37 copy number variation syndrome" "Interconversion of nucleotide di- and triphosphates" "3" "0" "1.040" "1.002" "1.048" "0.973" "1.015" "1.070" "1.038" "1.021" "0.892" "1772.2" "1843.8" "1775.2" "1856.8" "1725.0" "1798.0" "1897.1" "1838.8" "1809.3" "1580.7" "" "" "" "" "" "" "" "" "" "" "1593.4" "1491.9" "1605.7" "1812.5" "1423.5" "1798.0" "1420.5" "1624.1" "1618.9" "564.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1131809670189224217" "False" "High" "IsMasterProtein" "Q96EY7" "Small ribosomal subunit protein mS39 OS=Homo sapiens OX=9606 GN=PTCD3 PE=1 SV=3" "0.000" "False" "48.034" "20" "13" "20" "12" "689" "78.5" "6.42" "62.52" "13" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "translation activity;nucleic acid binding activity" "Pf13041, Pf13812" "55037" "ENSG00000132300" "PTCD3" "A6NHD2; D6W5M1; hsa:55037; Q597H0; Q658Y9; Q96EY7; Q9BUZ8; Q9NWL0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.899" "0.843" "0.940" "0.924" "0.885" "1.001" "0.889" "0.880" "1.484" "1138.0" "1022.8" "959.6" "1070.2" "1051.5" "1007.2" "1139.7" "1012.3" "1001.4" "1688.4" "" "" "" "" "" "" "" "" "" "" "1023.2" "827.6" "868.0" "1044.7" "867.8" "1007.2" "853.4" "894.1" "896.0" "602.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023891521044108187" "False" "High" "IsMasterProtein" "Q96BX8" "MOB kinase activator 3A OS=Homo sapiens OX=9606 GN=MOB3A PE=1 SV=1" "0.000" "False" "47.999" "42" "9" "21" "9" "217" "25.4" "8.63" "83.64" "9" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "126308" "ENSG00000172081" "MOB3A" "B3KTF1; hsa:126308; O75249; Q8TF69; Q96BX8" "" "" "0" "0" "1.051" "1.027" "0.969" "1.049" "0.939" "1.078" "1.039" "0.950" "0.863" "1788.1" "1879.2" "1836.3" "1733.4" "1875.9" "1679.6" "1926.8" "1857.0" "1698.2" "1542.5" "" "" "" "" "" "" "" "" "" "" "1607.6" "1520.6" "1661.0" "1692.1" "1548.1" "1679.6" "1442.8" "1640.2" "1519.5" "550.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4636367879172640363" "False" "High" "IsMasterProtein" "P24666" "Low molecular weight phosphotyrosine protein phosphatase OS=Homo sapiens OX=9606 GN=ACP1 PE=1 SV=3" "0.000" "False" "47.966" "72" "8" "19" "8" "158" "18.0" "6.74" "63.06" "8" "" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01451" "52" "ENSG00000143727" "ACP1" "A8K1L9; B5MCC7; hsa:52; P24666; P24667; Q16035; Q16036; Q16725; Q3KQX8; Q53RU0" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.951" "0.970" "0.988" "0.969" "0.979" "0.972" "0.948" "0.962" "1.623" "1027.6" "976.9" "997.0" "1015.7" "995.2" "1005.8" "998.7" "974.3" "988.1" "1668.0" "" "" "" "" "" "" "" "" "" "" "923.9" "790.5" "901.8" "991.5" "821.3" "1005.8" "747.8" "860.6" "884.1" "595.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4990507016878311040" "False" "High" "IsMasterProtein" "P42126" "Enoyl-CoA delta isomerase 1, mitochondrial OS=Homo sapiens OX=9606 GN=ECI1 PE=1 SV=1" "0.000" "False" "47.912" "31" "8" "14" "8" "302" "32.8" "8.54" "58.95" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00378" "1632" "ENSG00000167969" "ECI1" "A8K512; hsa:1632; P42126; Q13290; Q7Z2L6; Q7Z2L7; Q9BUB8; Q9BW05; Q9UDG6" "Fatty acid beta-oxidation; Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial protein degradation; mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" "5" "0" "0.992" "1.013" "0.992" "1.042" "1.027" "1.032" "0.998" "0.994" "0.776" "1086.3" "1078.0" "1100.8" "1077.6" "1132.4" "1115.5" "1120.9" "1083.9" "1079.7" "843.3" "" "" "" "" "" "" "" "" "" "" "976.6" "872.3" "995.7" "1051.9" "934.4" "1115.5" "839.3" "957.4" "966.1" "301.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939925399894006679" "False" "High" "IsMasterProtein" "Q9NWU2" "Glucose-induced degradation protein 8 homolog OS=Homo sapiens OX=9606 GN=GID8 PE=1 SV=1" "0.000" "False" "47.874" "43" "6" "18" "6" "228" "26.7" "4.97" "66.04" "6" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08513, Pf10607" "54994" "ENSG00000101193" "GID8" "E1P5I3; hsa:54994; Q8N5M5; Q9NWU2" "Ciliary landscape" "" "1" "0" "1.020" "0.964" "0.971" "1.002" "1.038" "0.988" "0.956" "1.018" "0.847" "869.7" "887.1" "838.8" "844.7" "871.6" "903.1" "859.2" "831.6" "885.5" "736.6" "" "" "" "" "" "" "" "" "" "" "781.9" "717.8" "758.7" "824.6" "719.2" "903.1" "643.3" "734.6" "792.3" "262.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8157399823022384529" "False" "High" "IsMasterProtein" "Q99567" "Nuclear pore complex protein Nup88 OS=Homo sapiens OX=9606 GN=NUP88 PE=1 SV=2" "0.000" "False" "47.869" "18" "11" "16" "11" "741" "83.5" "5.69" "64.26" "11" "other metabolic processes;transport" "cytosol;nucleus" "other molecular function" "Pf10168" "4927" "ENSG00000108559" "NUP88" "D3DTM2; hsa:4927; Q99567; Q9BWE5" "Ciliary landscape" "ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; HCMV Early Events; SUMOylation of DNA damage response and repair proteins; HCMV Late Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "29" "0" "0.997" "1.123" "0.986" "0.993" "1.051" "0.992" "0.953" "1.112" "1.673" "1307.0" "1303.1" "1468.4" "1288.5" "1298.1" "1373.3" "1296.7" "1245.0" "1454.0" "2186.6" "" "" "" "" "" "" "" "" "" "" "1175.1" "1054.4" "1328.2" "1257.8" "1071.2" "1373.3" "971.0" "1099.7" "1301.1" "780.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5198752139468277763" "False" "High" "IsMasterProtein" "Q96PK6" "RNA-binding protein 14 OS=Homo sapiens OX=9606 GN=RBM14 PE=1 SV=2" "0.000" "False" "47.858" "22" "13" "15" "13" "669" "69.4" "9.67" "53.31" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00076" "100526737; 10432" "ENSG00000239306" "RBM14" "B0LM41; B3KMN4; D6RGD8; hsa:100526737; hsa:10432; O75932; Q2PYN1; Q53GV1; Q68DQ9; Q96PK5; Q96PK6" "Ciliary landscape" "RUNX2 regulates bone development" "2" "0" "1.010" "1.054" "1.117" "0.940" "1.075" "1.059" "0.934" "0.942" "5.407" "586.1" "592.2" "617.7" "654.8" "551.2" "630.3" "620.4" "547.2" "552.3" "3169.1" "" "" "" "" "" "" "" "" "" "" "527.0" "479.2" "558.8" "639.2" "454.9" "630.3" "464.6" "483.3" "494.2" "1131.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2260293505055803748" "False" "High" "IsMasterProtein" "Q5JSZ5" "Protein PRRC2B OS=Homo sapiens OX=9606 GN=PRRC2B PE=1 SV=2" "0.000" "False" "47.851" "8" "15" "17" "13" "2229" "242.8" "8.34" "54.56" "15" "other biological processes" "" "" "Pf07001" "84726" "ENSG00000288701" "PRRC2B" "hsa:84726; O60270; Q5JSZ5; Q5JSZ7; Q66VZ2; Q68CR0; Q96EI9; Q9H683" "" "" "0" "0" "0.955" "1.171" "0.963" "0.926" "1.079" "0.981" "0.938" "0.972" "0.984" "885.4" "845.5" "1037.1" "852.9" "820.1" "955.0" "868.7" "830.6" "860.4" "871.2" "" "" "" "" "" "" "" "" "" "" "796.1" "684.1" "938.0" "832.6" "676.7" "955.0" "650.5" "733.7" "769.9" "311.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6083245125138804483" "False" "High" "IsMasterProtein" "Q15027" "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ACAP1 PE=1 SV=1" "0.000" "False" "47.808" "23" "12" "13" "11" "740" "81.5" "7.66" "60.59" "12" "transport" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00023, Pf00169, Pf01412, Pf16746" "9744" "ENSG00000072818; ENSG00000288169" "ACAP1" "hsa:9744; Q15027; Q53XN9" "Nucleotide-binding oligomerization domain (NOD) pathway" "" "1" "0" "1.045" "1.062" "1.000" "1.080" "1.005" "1.077" "1.036" "1.018" "1.492" "607.7" "634.7" "645.6" "607.6" "656.3" "610.9" "654.4" "629.4" "618.8" "906.7" "" "" "" "" "" "" "" "" "" "" "546.4" "513.6" "583.9" "593.1" "541.6" "610.9" "490.0" "556.0" "553.7" "323.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6355678057945092611" "False" "High" "IsMasterProtein" "P42695" "Condensin-2 complex subunit D3 OS=Homo sapiens OX=9606 GN=NCAPD3 PE=1 SV=2" "0.000" "False" "47.728" "10" "13" "14" "13" "1498" "168.8" "7.50" "50.37" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12717" "23310" "ENSG00000151503" "NCAPD3" "A6NFS2; hsa:23310; P42695; Q4KMQ9" "" "Condensation of Prophase Chromosomes" "1" "0" "0.998" "1.018" "0.932" "0.985" "1.085" "0.995" "0.975" "1.038" "1.160" "747.5" "746.0" "760.6" "696.6" "736.3" "811.0" "743.4" "728.5" "775.6" "867.1" "" "" "" "" "" "" "" "" "" "" "672.1" "603.6" "688.0" "679.9" "607.6" "811.0" "556.6" "643.5" "694.0" "309.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5358245641494386502" "False" "High" "IsMasterProtein" "Q14012" "Calcium/calmodulin-dependent protein kinase type 1 OS=Homo sapiens OX=9606 GN=CAMK1 PE=1 SV=1" "0.000" "False" "47.708" "28" "8" "15" "4" "370" "41.3" "5.29" "59.27" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00069" "8536" "ENSG00000134072" "CAMK1" "hsa:8536; Q14012; Q3KPF6" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Physico-chemical features and toxicity-associated pathways; Clear cell renal cell carcinoma pathways; Fragile X syndrome; CAMKK2 pathway; Calcium regulation in cardiac cells" "Negative regulation of NMDA receptor-mediated neuronal transmission; Activation of RAC1 downstream of NMDARs" "8" "0" "1.161" "1.074" "0.964" "1.033" "1.035" "1.005" "0.976" "1.003" "1.033" "301.4" "349.7" "323.8" "290.6" "311.4" "311.9" "303.0" "294.1" "302.3" "311.4" "" "" "" "" "" "" "" "" "" "" "271.0" "283.0" "292.9" "283.6" "257.0" "311.9" "226.9" "259.7" "270.5" "111.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144550306187805462" "False" "High" "IsMasterProtein" "Q68E01" "Integrator complex subunit 3 OS=Homo sapiens OX=9606 GN=INTS3 PE=1 SV=1" "0.000" "False" "47.674" "16" "14" "16" "14" "1043" "118.0" "5.80" "56.50" "14" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf10189" "65123" "ENSG00000143624; ENSG00000262826" "INTS3" "A8K1W0; B4DQC8; B4E3U9; D3DV57; hsa:65123; Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q68E01; Q69YR5; Q6AI57; Q6DKG7; Q6MZQ4; Q6MZZ9; Q8NC46; Q8TB23; Q9H6S9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.043" "0.945" "1.056" "1.099" "1.015" "1.048" "1.063" "1.015" "1.170" "754.8" "787.0" "713.0" "796.9" "829.5" "765.8" "791.1" "802.2" "766.2" "883.2" "" "" "" "" "" "" "" "" "" "" "678.6" "636.8" "644.9" "777.9" "684.5" "765.8" "592.4" "708.6" "685.6" "315.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6653202710982051878" "False" "High" "IsMasterProtein" "Q96RL1" "BRCA1-A complex subunit RAP80 OS=Homo sapiens OX=9606 GN=UIMC1 PE=1 SV=2" "0.000" "False" "47.650" "17" "12" "14" "12" "719" "79.7" "5.45" "54.35" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf18282" "51720" "ENSG00000087206" "UIMC1" "A8MSA1; B3KMZ1; B4E3N2; hsa:51720; Q5XKQ1; Q7Z3W7; Q8N5B9; Q96RL1; Q9BZR1; Q9BZR5; Q9UHX7" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "0.984" "0.900" "0.950" "1.001" "0.966" "1.020" "0.985" "0.933" "1.011" "1414.4" "1391.2" "1273.0" "1343.5" "1415.4" "1366.8" "1443.3" "1393.5" "1319.8" "1429.8" "" "" "" "" "" "" "" "" "" "" "1271.7" "1125.7" "1151.4" "1311.5" "1168.0" "1366.8" "1080.7" "1230.8" "1181.0" "510.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "132073470049357313" "False" "High" "IsMasterProtein" "Q58FF6" "Putative heat shock protein HSP 90-beta 4 OS=Homo sapiens OX=9606 GN=HSP90AB4P PE=5 SV=1" "0.000" "False" "47.631" "10" "7" "73" "1" "505" "58.2" "4.73" "234.90" "7" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00183" "" "" "HSP90AB4P" "Q58FF6" "" "" "0" "0" "0.871" "0.860" "0.988" "1.039" "0.879" "0.990" "0.912" "0.952" "0.572" "143.4" "124.9" "123.3" "141.7" "148.9" "126.0" "141.9" "130.7" "136.5" "82.0" "" "" "" "" "" "" "" "" "" "" "128.9" "101.1" "111.6" "138.3" "122.9" "126.0" "106.2" "115.5" "122.1" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7154338873387211180" "False" "High" "IsMasterProtein" "Q8TDQ7" "Glucosamine-6-phosphate isomerase 2 OS=Homo sapiens OX=9606 GN=GNPDA2 PE=1 SV=1" "0.000" "False" "47.619" "53" "10" "15" "5" "276" "31.1" "6.95" "61.93" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01182" "132789" "ENSG00000163281" "GNPDA2" "B4DJF3; hsa:132789; Q2VYF1; Q59EA7; Q8NCZ8; Q8TDQ7; Q96BJ4; Q96NC6" "" "Glycolysis" "1" "0" "1.038" "1.081" "0.928" "1.097" "1.024" "1.053" "0.991" "1.064" "0.720" "558.9" "580.1" "604.3" "518.8" "613.2" "572.6" "588.6" "554.1" "594.5" "402.5" "" "" "" "" "" "" "" "" "" "" "502.5" "469.4" "546.6" "506.4" "506.0" "572.6" "440.8" "489.4" "532.0" "143.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2735556346422021928" "False" "High" "IsMasterProtein" "P53384" "Cytosolic Fe-S cluster assembly factor NUBP1 OS=Homo sapiens OX=9606 GN=NUBP1 PE=1 SV=2" "0.000" "False" "47.598" "44" "8" "15" "8" "320" "34.5" "5.33" "61.98" "8" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "4682" "ENSG00000103274" "NUBP1" "hsa:4682; P53384; Q32M30; Q498A9; Q53FS7" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "0.992" "0.948" "1.032" "1.048" "0.957" "1.015" "0.996" "0.981" "0.811" "498.4" "494.2" "472.6" "514.5" "522.3" "476.8" "505.7" "496.3" "488.7" "404.3" "" "" "" "" "" "" "" "" "" "" "448.1" "399.9" "427.5" "502.3" "431.0" "476.8" "378.7" "438.4" "437.3" "144.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "508361359361041752" "False" "High" "IsMasterProtein" "O00193" "Small acidic protein OS=Homo sapiens OX=9606 GN=SMAP PE=1 SV=1" "0.000" "False" "47.587" "40" "6" "20" "6" "183" "20.3" "4.72" "83.82" "6" "" "" "" "Pf15477" "10944" "ENSG00000110696" "SMAP" "B2RD28; hsa:10944; O00193" "" "" "0" "0" "0.911" "0.879" "0.946" "0.911" "0.907" "0.921" "0.959" "0.863" "0.718" "2069.6" "1885.4" "1818.9" "1957.3" "1886.4" "1877.4" "1905.1" "1985.4" "1787.1" "1485.3" "" "" "" "" "" "" "" "" "" "" "1860.8" "1525.6" "1645.3" "1910.6" "1556.7" "1877.4" "1426.5" "1753.7" "1599.1" "530.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8229141518412539790" "False" "High" "IsMasterProtein" "P68036" "Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens OX=9606 GN=UBE2L3 PE=1 SV=1" "0.000" "False" "47.539" "52" "6" "22" "6" "154" "17.9" "8.51" "97.93" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00179" "7332" "ENSG00000185651" "UBE2L3" "B2R4A7; B4DDG1; B4DSZ4; E7EWS7; hsa:7332; P51966; P68036; P70653; Q9HAV1" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; Regulation of necroptotic cell death; Regulation of TNFR1 signaling" "7" "0" "0.966" "0.975" "0.978" "0.907" "1.039" "0.904" "1.023" "0.906" "0.709" "2233.4" "2157.9" "2177.0" "2185.3" "2025.1" "2319.9" "2018.7" "2284.6" "2022.9" "1584.2" "" "" "" "" "" "" "" "" "" "" "2008.1" "1746.1" "1969.1" "2133.2" "1671.2" "2319.9" "1511.5" "2017.9" "1810.1" "565.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1987024820899376297" "False" "High" "IsMasterProtein" "Q9BRA2" "Thioredoxin domain-containing protein 17 OS=Homo sapiens OX=9606 GN=TXNDC17 PE=1 SV=1" "0.000" "False" "47.521" "59" "6" "25" "6" "123" "13.9" "5.52" "84.77" "6" "signal transduction;other biological processes" "cytosol" "other molecular function" "Pf06110" "84817" "ENSG00000129235" "TXNDC17" "A8K7E8; hsa:84817; Q9BRA2" "" "" "0" "0" "0.984" "0.987" "0.961" "0.997" "0.990" "0.999" "1.022" "0.975" "0.797" "2130.9" "2096.7" "2103.2" "2048.7" "2124.1" "2110.5" "2129.7" "2177.6" "2076.6" "1698.3" "" "" "" "" "" "" "" "" "" "" "1915.9" "1696.5" "1902.5" "1999.8" "1752.8" "2110.5" "1594.6" "1923.4" "1858.1" "606.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9025151423134884799" "False" "High" "IsMasterProtein" "Q9BY42" "Replication termination factor 2 OS=Homo sapiens OX=9606 GN=RTF2 PE=1 SV=3" "0.000" "False" "47.492" "40" "11" "16" "11" "306" "33.9" "8.59" "56.28" "11" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04641" "51507" "ENSG00000022277" "RTF2" "E1P5Z9; hsa:51507; Q9BY42; Q9BYL7; Q9HCV9; Q9NX29; Q9NZZ8; Q9P002; Q9UHW3" "" "" "0" "0" "0.903" "0.984" "0.966" "1.050" "1.054" "1.051" "1.059" "1.089" "0.846" "1532.0" "1383.0" "1506.8" "1480.6" "1609.3" "1614.4" "1610.0" "1622.6" "1668.3" "1296.0" "" "" "" "" "" "" "" "" "" "" "1377.4" "1119.0" "1362.9" "1445.2" "1328.0" "1614.4" "1205.5" "1433.2" "1492.8" "462.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431092815676892718" "False" "High" "IsMasterProtein" "Q8N0Y7" "Probable phosphoglycerate mutase 4 OS=Homo sapiens OX=9606 GN=PGAM4 PE=1 SV=1" "0.000" "False" "47.433" "31" "5" "23" "1" "254" "28.8" "6.65" "88.40" "5" "other metabolic processes;other biological processes" "cytoskeleton" "other molecular function" "Pf00300" "441531" "ENSG00000226784" "PGAM4" "hsa:441531; Q5JPN2; Q8N0Y7; Q8NI24; Q8NI25; Q8NI26" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8162183631045646946" "False" "High" "IsMasterProtein" "Q01085" "Nucleolysin TIAR OS=Homo sapiens OX=9606 GN=TIAL1 PE=1 SV=1" "0.000" "False" "47.380" "34" "11" "19" "7" "375" "41.6" "7.74" "72.47" "11" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "7073" "ENSG00000151923" "TIAL1" "A8K3T0; A8K4L9; hsa:7073; Q01085" "" "FGFR2 alternative splicing" "1" "0" "0.980" "1.010" "0.989" "0.978" "1.002" "0.951" "0.979" "0.932" "0.888" "1068.5" "1047.4" "1079.3" "1056.6" "1044.5" "1070.3" "1016.1" "1046.1" "995.5" "949.4" "" "" "" "" "" "" "" "" "" "" "960.7" "847.5" "976.2" "1031.4" "861.9" "1070.3" "760.8" "924.0" "890.8" "338.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7112262159952005485" "False" "High" "IsMasterProtein" "Q5T440" "Putative transferase CAF17, mitochondrial OS=Homo sapiens OX=9606 GN=IBA57 PE=1 SV=1" "0.000" "False" "47.339" "39" "10" "15" "10" "356" "38.1" "9.83" "59.66" "10" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "other molecular function" "" "200205" "ENSG00000181873" "IBA57" "hsa:200205; Q5T440" "" "" "0" "0" "1.023" "1.030" "1.010" "1.096" "0.998" "0.996" "1.032" "0.985" "0.863" "709.4" "726.0" "730.5" "716.3" "777.4" "707.7" "706.7" "732.2" "698.7" "612.2" "" "" "" "" "" "" "" "" "" "" "637.8" "587.4" "660.8" "699.2" "641.6" "707.7" "529.2" "646.7" "625.2" "218.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "350297391460659300" "False" "High" "IsMasterProtein" "Q96CT7" "Coiled-coil domain-containing protein 124 OS=Homo sapiens OX=9606 GN=CCDC124 PE=1 SV=1" "0.000" "False" "47.274" "51" "12" "18" "12" "223" "25.8" "9.54" "62.71" "12" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf06244" "115098" "ENSG00000007080" "CCDC124" "hsa:115098; Q96CT7" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.204" "1.177" "1.024" "1.152" "1.482" "1.177" "1.145" "1.134" "0.913" "1305.2" "1571.4" "1536.6" "1336.7" "1503.5" "1934.2" "1536.1" "1493.8" "1480.5" "1191.1" "" "" "" "" "" "" "" "" "" "" "1173.5" "1271.5" "1389.9" "1304.8" "1240.7" "1934.2" "1150.2" "1319.4" "1324.8" "425.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2091961222017639990" "False" "High" "IsMasterProtein" "Q13123" "Protein Red OS=Homo sapiens OX=9606 GN=IK PE=1 SV=3" "0.000" "False" "47.272" "22" "11" "18" "11" "557" "65.6" "6.64" "56.48" "11" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07807, Pf07808" "3550" "ENSG00000113141" "IK" "hsa:3550; Q13123; Q6IPD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.972" "1.048" "0.912" "1.002" "1.095" "0.981" "1.040" "1.016" "0.947" "1458.6" "1417.6" "1528.4" "1330.7" "1462.2" "1596.5" "1430.6" "1517.5" "1482.4" "1381.6" "" "" "" "" "" "" "" "" "" "" "1311.4" "1147.1" "1382.4" "1299.0" "1206.6" "1596.5" "1071.2" "1340.4" "1326.5" "493.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830448209821531490" "False" "High" "IsMasterProtein" "Q9GZS3" "Superkiller complex protein 8 OS=Homo sapiens OX=9606 GN=SKIC8 PE=1 SV=1" "0.000" "False" "47.234" "41" "8" "12" "8" "305" "33.6" "5.47" "52.99" "8" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "80349" "ENSG00000140395" "SKIC8" "D3DW84; hsa:80349; Q6IA22; Q7Z4X4; Q9GZS3" "" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events; mRNA decay by 3' to 5' exoribonuclease" "5" "0" "1.013" "1.053" "0.953" "1.045" "1.026" "0.999" "1.016" "1.032" "1.242" "896.9" "908.4" "944.1" "854.6" "937.2" "919.9" "896.0" "910.9" "925.9" "1114.2" "" "" "" "" "" "" "" "" "" "" "806.4" "735.0" "854.0" "834.2" "773.4" "919.9" "670.9" "804.5" "828.5" "397.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6108723454848240584" "False" "High" "IsMasterProtein" "Q7L7X3" "Serine/threonine-protein kinase TAO1 OS=Homo sapiens OX=9606 GN=TAOK1 PE=1 SV=1" "0.000" "False" "47.149" "15" "13" "15" "9" "1001" "116.0" "7.65" "55.33" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "57551" "ENSG00000160551" "TAOK1" "A2RUT8; B7ZLV6; hsa:57551; Q7L7X3; Q96L75; Q9H2K7; Q9H7S5; Q9P2I6" "Microtubule cytoskeleton regulation; MAPK signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "8" "0" "1.048" "1.047" "0.940" "1.020" "1.044" "1.001" "1.060" "1.056" "0.899" "464.6" "486.9" "486.5" "436.7" "474.0" "484.9" "465.1" "492.2" "490.7" "417.6" "" "" "" "" "" "" "" "" "" "" "417.7" "394.0" "440.0" "426.3" "391.2" "484.9" "348.3" "434.8" "439.0" "149.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1353658345851562217" "False" "High" "IsMasterProtein" "Q9BR76" "Coronin-1B OS=Homo sapiens OX=9606 GN=CORO1B PE=1 SV=1" "0.000" "False" "47.120" "26" "12" "19" "12" "489" "54.2" "5.88" "59.94" "12" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf08953, Pf16300" "57175" "ENSG00000172725" "CORO1B" "B2RD45; hsa:57175; Q9BR76" "" "" "0" "0" "0.999" "0.992" "0.976" "0.964" "0.967" "0.957" "0.960" "0.973" "0.926" "1640.0" "1638.8" "1626.6" "1600.4" "1580.8" "1585.8" "1568.9" "1574.7" "1596.2" "1518.7" "" "" "" "" "" "" "" "" "" "" "1474.5" "1326.0" "1471.3" "1562.2" "1304.5" "1585.8" "1174.7" "1390.9" "1428.3" "542.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4154359228263867930" "False" "High" "IsMasterProtein" "P46781" "Small ribosomal subunit protein uS4 OS=Homo sapiens OX=9606 GN=RPS9 PE=1 SV=3" "0.000" "False" "47.093" "47" "12" "22" "12" "194" "22.6" "10.65" "63.27" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00163, Pf01479" "6203" "ENSG00000170889; ENSG00000274005; ENSG00000274626; ENSG00000274646; ENSG00000274950; ENSG00000275323; ENSG00000277079; ENSG00000277359; ENSG00000278081; ENSG00000278270" "RPS9" "A9C4C1; hsa:6203; P46781; Q4QRK7; Q9BVZ0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.905" "0.875" "0.787" "0.849" "0.911" "0.835" "0.761" "0.949" "1.097" "1638.5" "1482.6" "1433.2" "1288.8" "1391.3" "1492.7" "1368.6" "1246.7" "1554.2" "1798.2" "" "" "" "" "" "" "" "" "" "" "1473.2" "1199.7" "1296.4" "1258.0" "1148.1" "1492.7" "1024.8" "1101.2" "1390.7" "641.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2320563030437256339" "False" "High" "IsMasterProtein" "Q5RKV6" "Exosome complex component MTR3 OS=Homo sapiens OX=9606 GN=EXOSC6 PE=1 SV=1" "0.000" "False" "47.074" "39" "9" "21" "9" "272" "28.2" "6.28" "87.90" "9" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf01138" "118460" "ENSG00000223496" "EXOSC6" "hsa:118460; Q5RKV6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.989" "0.990" "1.005" "0.975" "1.022" "0.941" "0.983" "0.980" "0.668" "1014.4" "1002.9" "1003.9" "1019.5" "988.6" "1036.2" "954.3" "997.5" "994.3" "677.1" "" "" "" "" "" "" "" "" "" "" "912.0" "811.5" "908.0" "995.2" "815.8" "1036.2" "714.6" "881.0" "889.7" "241.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8178776459123092866" "False" "High" "IsMasterProtein" "P05387" "Large ribosomal subunit protein P2 OS=Homo sapiens OX=9606 GN=RPLP2 PE=1 SV=1" "0.000" "False" "47.027" "56" "6" "27" "4" "115" "11.7" "4.54" "108.56" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00428" "6181" "ENSG00000177600" "RPLP2" "hsa:6181; P05387; Q6FG96" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins; Opioid receptor pathways" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "2" "0.971" "0.947" "0.982" "1.135" "1.092" "1.016" "1.274" "1.007" "0.629" "1733.0" "1683.3" "1641.3" "1701.8" "1967.6" "1893.2" "1761.4" "2207.8" "1744.8" "1089.6" "" "" "" "" "" "" "" "" "" "" "1558.1" "1362.0" "1484.6" "1661.2" "1623.7" "1893.2" "1318.9" "1950.1" "1561.3" "389.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-101820050033511890" "False" "High" "IsMasterProtein" "Q14966" "Zinc finger protein 638 OS=Homo sapiens OX=9606 GN=ZNF638 PE=1 SV=2" "0.000" "False" "47.012" "7" "12" "15" "12" "1978" "220.5" "6.38" "54.38" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12171" "27332" "ENSG00000075292" "ZNF638" "A0A096LPH6; B5MDV1; B7ZLD1; hsa:27332; Q14966; Q53R34; Q5XJ05; Q68DP3; Q6P2H2; Q7Z3T7; Q8NF92; Q8TCA1; Q9H2G1; Q9NP37" "" "Transcriptional regulation of white adipocyte differentiation" "1" "0" "1.028" "1.016" "1.003" "1.033" "1.009" "1.053" "0.987" "0.926" "1.002" "826.2" "849.0" "839.7" "828.8" "853.1" "833.7" "870.4" "815.8" "764.8" "827.8" "" "" "" "" "" "" "" "" "" "" "742.9" "687.0" "759.5" "809.0" "704.0" "833.7" "651.7" "720.6" "684.3" "295.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8965718931841673636" "False" "High" "IsMasterProtein" "Q9Y496" "Kinesin-like protein KIF3A OS=Homo sapiens OX=9606 GN=KIF3A PE=1 SV=4" "0.000" "False" "47.000" "21" "13" "17" "12" "699" "80.0" "6.54" "49.88" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "11127" "ENSG00000131437" "KIF3A" "A8MSW9; hsa:11127; Q59EN1; Q86XE9; Q9Y496; Q9Y6V4" "Hedgehog signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins; Activation of SMO; Hedgehog 'off' state" "11" "0" "1.025" "1.057" "1.025" "1.026" "1.023" "1.071" "1.061" "1.014" "1.245" "876.0" "898.3" "926.0" "897.6" "898.7" "896.5" "938.6" "929.8" "888.7" "1091.0" "" "" "" "" "" "" "" "" "" "" "787.6" "726.8" "837.6" "876.2" "741.6" "896.5" "702.8" "821.3" "795.2" "389.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454366493935613494" "False" "High" "IsMasterProtein" "P19404" "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV2 PE=1 SV=2" "0.000" "False" "46.999" "45" "10" "17" "10" "249" "27.4" "8.06" "63.53" "10" "other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01257" "4729" "ENSG00000178127" "NDUFV2" "hsa:4729; P19404; Q9BV41" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.967" "1.015" "0.925" "1.032" "0.961" "0.997" "1.060" "1.037" "0.803" "1934.3" "1871.1" "1963.8" "1789.7" "1997.0" "1858.4" "1928.6" "2049.8" "2005.0" "1553.8" "" "" "" "" "" "" "" "" "" "" "1739.2" "1514.0" "1776.3" "1747.0" "1648.0" "1858.4" "1444.1" "1810.5" "1794.1" "554.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5219962160653880547" "False" "High" "IsMasterProtein" "Q15785" "Mitochondrial import receptor subunit TOM34 OS=Homo sapiens OX=9606 GN=TOMM34 PE=1 SV=2" "0.000" "False" "46.981" "38" "10" "17" "10" "309" "34.5" "8.98" "69.30" "10" "other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf00515" "10953" "ENSG00000025772" "TOMM34" "hsa:10953; Q15785; Q53GH9; Q6IBN7; Q9NTZ3" "" "" "0" "0" "0.994" "1.055" "0.976" "1.013" "1.006" "1.032" "0.929" "0.993" "4.003" "1395.0" "1386.2" "1471.8" "1361.9" "1413.1" "1403.0" "1439.6" "1295.4" "1385.6" "5584.8" "" "" "" "" "" "" "" "" "" "" "1254.3" "1121.7" "1331.3" "1329.4" "1166.1" "1403.0" "1077.9" "1144.1" "1239.8" "1993.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629403927496459035" "False" "High" "IsMasterProtein" "P62987" "Ubiquitin-ribosomal protein eL40 fusion protein OS=Homo sapiens OX=9606 GN=UBA52 PE=1 SV=2" "0.000" "False" "46.931" "54" "8" "183" "1" "128" "14.7" "9.83" "565.58" "8" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00240, Pf01020" "7311" "ENSG00000221983" "UBA52" "hsa:7311; P02248; P02249; P02250; P14793; P62987; P62988; Q29120; Q6LBL4; Q6LDU5; Q8WYN8; Q91887; Q91888; Q9BWD6; Q9BX98; Q9UEF2; Q9UEG1; Q9UEK8; Q9UPK7" "DNA replication; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Membrane binding and targetting of GAG proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Circadian Clock; Downregulation of SMAD2/3:SMAD4 transcriptional activity; NOTCH1 Intracellular Domain Regulates Transcription; Peroxisomal protein import; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; MAPK6/MAPK4 signaling; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of PLK1 Activity at G2/M Transition; Regulation of TP53 Degradation; APC/C:Cdc20 mediated degradation of Cyclin B; Ovarian tumor domain proteases; Regulation of signaling by CBL; Signaling by CSF1 (M-CSF) in myeloid cells; FCERI mediated NF-kB activation; Cyclin D associated events in G1; Inactivation of CSF3 (G-CSF) signaling; Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Regulation of innate immune responses to cytosolic DNA; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; MAP3K8 (TPL2)-dependent MAPK1/3 activation; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Stimuli-sensing channels; Amyloid fiber formation; Fanconi Anemia Pathway; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy; Aggrephagy; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 HD Domain Mutants; NOTCH2 Activation and Transmission of Signal to the Nucleus; NOTCH3 Activation and Transmission of Signal to the Nucleus; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; ER Quality Control Compartment (ERQC); SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of TP53 Activity through Phosphorylation; Signaling by ALK fusions and activated point mutants; Metalloprotease DUBs; Regulation of necroptotic cell death; Oncogene Induced Senescence; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Negative regulation of FLT3; Downregulation of ERBB2:ERBB3 signaling; Cargo recognition for clathrin-mediated endocytosis; Interferon alpha/beta signaling; Regulation of TP53 Activity through Methylation; Processing of DNA double-strand break ends; Regulation of BACH1 activity; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling; EGFR downregulation; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; Prevention of phagosomal-lysosomal fusion; Downregulation of TGF-beta receptor signaling; HDR through Homologous Recombination (HRR); TICAM1-dependent activation of IRF3/IRF7; TICAM1,TRAF6-dependent induction of TAK1 complex; Glycogen synthesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Modulation by Mtb of host immune system; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway; Spry regulation of FGF signaling; RAS processing; PINK1-PRKN Mediated Mitophagy; Josephin domain DUBs; Regulation of FZD by ubiquitination; Chaperone Mediated Autophagy; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; InlA-mediated entry of Listeria monocytogenes into host cells; Formation of Incision Complex in GG-NER; Iron uptake and transport; Recognition of DNA damage by PCNA-containing replication complex; VLDLR internalisation and degradation; Myoclonic epilepsy of Lafora; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Negative regulation of MAPK pathway; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); NRIF signals cell death from the nucleus; Assembly Of The HIV Virion; Dual Incision in GG-NER; Translesion Synthesis by POLH; Downregulation of ERBB4 signaling; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Gap-filling DNA repair synthesis and ligation in GG-NER; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Regulation of PTEN localization; Pexophagy; Maturation of protein E; Maturation of protein E; FLT3 signaling by CBL mutants; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "199" "0" "1.174" "0.803" "0.731" "0.777" "1.178" "0.702" "0.786" "0.728" "1.016" "77.0" "90.4" "61.8" "56.3" "59.8" "90.6" "54.0" "60.5" "56.1" "78.2" "" "" "" "" "" "" "" "" "" "" "69.2" "73.1" "55.9" "54.9" "49.3" "90.6" "40.5" "53.4" "50.2" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547321454778217727" "False" "High" "IsMasterProtein" "Q6PID6" "Tetratricopeptide repeat protein 33 OS=Homo sapiens OX=9606 GN=TTC33 PE=1 SV=2" "0.000" "False" "46.902" "39" "8" "16" "8" "262" "29.4" "5.44" "65.52" "8" "" "" "" "" "23548" "ENSG00000113638" "TTC33" "B2R6G0; hsa:23548; O95105; Q6PID6" "" "" "0" "0" "0.940" "0.991" "1.009" "0.984" "0.975" "0.978" "0.996" "0.975" "1.294" "535.4" "503.3" "530.7" "540.1" "527.0" "522.1" "523.4" "533.1" "522.0" "692.6" "" "" "" "" "" "" "" "" "" "" "481.4" "407.3" "480.0" "527.2" "434.9" "522.1" "391.9" "470.8" "467.1" "247.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4697370261215889932" "False" "High" "IsMasterProtein" "O43583" "Density-regulated protein OS=Homo sapiens OX=9606 GN=DENR PE=1 SV=2" "0.000" "False" "46.861" "46" "7" "21" "7" "198" "22.1" "5.30" "90.22" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "nucleic acid binding activity" "Pf01253, Pf21023" "8562" "ENSG00000139726" "DENR" "hsa:8562; O43583; Q9H3U6; Q9UKZ0" "" "" "0" "0" "0.869" "0.940" "0.924" "0.938" "0.963" "0.950" "0.989" "0.932" "0.675" "2903.4" "2522.6" "2730.2" "2684.0" "2723.0" "2795.6" "2758.6" "2871.0" "2705.6" "1960.2" "" "" "" "" "" "" "" "" "" "" "2610.4" "2041.2" "2469.6" "2619.9" "2247.1" "2795.6" "2065.6" "2535.9" "2421.0" "699.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2602489287625283403" "False" "High" "IsMasterProtein" "P62330" "ADP-ribosylation factor 6 OS=Homo sapiens OX=9606 GN=ARF6 PE=1 SV=2" "0.000" "False" "46.852" "53" "7" "20" "6" "175" "20.1" "8.95" "78.12" "7" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00025" "382" "ENSG00000165527" "ARF6" "hsa:382; P26438; P62330; Q6FGZ2" "VEGFA-VEGFR2 signaling; Ras signaling; EGF/EGFR signaling pathway; IL-18 signaling pathway; Insulin signaling; CCL18 signaling pathway; 2q13 copy number variation syndrome" "Clathrin-mediated endocytosis; TBC/RABGAPs; MET receptor recycling" "10" "0" "1.017" "1.042" "1.090" "1.080" "1.096" "1.007" "1.008" "1.109" "0.863" "1531.0" "1557.0" "1595.2" "1668.5" "1654.1" "1677.7" "1541.9" "1542.8" "1697.2" "1321.7" "" "" "" "" "" "" "" "" "" "" "1376.5" "1259.9" "1442.9" "1628.7" "1365.0" "1677.7" "1154.5" "1362.7" "1518.6" "471.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1978965257736533934" "False" "High" "IsMasterProtein" "Q9NYK5" "Large ribosomal subunit protein mL39 OS=Homo sapiens OX=9606 GN=MRPL39 PE=1 SV=3" "0.000" "False" "46.798" "35" "11" "15" "11" "338" "38.7" "7.65" "57.78" "11" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "" "54148" "ENSG00000154719" "MRPL39" "C9JYA5; hsa:54148; Q32Q74; Q5QTR3; Q96Q65; Q9BSQ7; Q9BZV6; Q9NX44; Q9NYK5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.038" "1.068" "1.027" "1.033" "1.034" "1.038" "1.051" "1.077" "0.898" "1142.3" "1185.2" "1220.0" "1172.9" "1180.4" "1181.2" "1185.8" "1200.5" "1230.2" "1025.7" "" "" "" "" "" "" "" "" "" "" "1027.0" "959.0" "1103.5" "1144.9" "974.1" "1181.2" "887.9" "1060.4" "1100.8" "366.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4078763853778873139" "False" "High" "IsMasterProtein" "O95816" "BAG family molecular chaperone regulator 2 OS=Homo sapiens OX=9606 GN=BAG2 PE=1 SV=1" "0.000" "False" "46.751" "47" "10" "18" "10" "211" "23.8" "6.70" "64.45" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "" "9532" "ENSG00000112208" "BAG2" "B4DXE2; hsa:9532; O95816; Q08AS9; Q6FID0" "Pleural mesothelioma" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.052" "1.096" "0.951" "1.090" "1.163" "1.073" "1.070" "1.189" "1.420" "1780.6" "1872.4" "1952.0" "1692.5" "1940.8" "2070.6" "1911.1" "1905.4" "2117.3" "2527.9" "" "" "" "" "" "" "" "" "" "" "1601.0" "1515.1" "1765.7" "1652.1" "1601.6" "2070.6" "1431.0" "1682.9" "1894.5" "902.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5005223025872710581" "False" "High" "IsMasterProtein" "O60524" "Ribosome quality control complex subunit NEMF OS=Homo sapiens OX=9606 GN=NEMF PE=1 SV=4" "0.000" "False" "46.743" "13" "14" "16" "14" "1076" "122.9" "6.35" "54.62" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf05670, Pf05833, Pf11923" "9147" "ENSG00000165525" "NEMF" "A0JLQ3; B3KSK1; B4DDL3; B4DHA9; B4E3F3; hsa:9147; O60524; Q32Q66; Q8WW70; Q9NWG1" "" "" "0" "0" "0.969" "0.964" "0.922" "0.945" "0.940" "0.982" "0.849" "0.926" "1.530" "821.9" "796.2" "792.6" "758.2" "776.4" "772.9" "807.4" "697.5" "761.1" "1257.6" "" "" "" "" "" "" "" "" "" "" "739.0" "644.2" "716.9" "740.1" "640.7" "772.9" "604.6" "616.1" "681.0" "448.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8991505405555366750" "False" "High" "IsMasterProtein" "Q8TED0" "U3 small nucleolar RNA-associated protein 15 homolog OS=Homo sapiens OX=9606 GN=UTP15 PE=1 SV=3" "0.000" "False" "46.683" "29" "15" "17" "15" "518" "58.4" "9.11" "54.11" "15" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf00400, Pf09384" "84135" "ENSG00000164338" "UTP15" "B4DU75; B4DXK8; hsa:84135; Q6IA60; Q8TED0; Q96E08; Q9H9F8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.032" "1.281" "0.846" "0.977" "1.359" "0.897" "0.990" "1.319" "0.590" "1212.7" "1251.0" "1552.9" "1025.8" "1185.2" "1647.8" "1087.2" "1200.7" "1600.0" "715.2" "" "" "" "" "" "" "" "" "" "" "1090.3" "1012.2" "1404.7" "1001.3" "978.0" "1647.8" "814.1" "1060.5" "1431.7" "255.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6174880606405183757" "False" "High" "IsMasterProtein" "P56545" "C-terminal-binding protein 2 OS=Homo sapiens OX=9606 GN=CTBP2 PE=1 SV=1" "0.000" "False" "46.667" "27" "11" "19" "7" "445" "48.9" "6.95" "62.55" "11" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00389, Pf02826" "1488" "ENSG00000175029" "CTBP2" "A8K2X5; D3DRF5; hsa:1488; O43449; P56545; Q5SQP7; Q69YI3; Q86SV0; Q8IY44; Q9H2T8" "Neural crest differentiation; Notch signaling; Mesodermal commitment pathway; Wnt signaling pathway and pluripotency; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Pleural mesothelioma" "Repression of WNT target genes; Signaling by TCF7L2 mutants" "11" "0" "0.998" "0.978" "0.995" "1.011" "0.962" "1.036" "1.020" "0.996" "0.861" "546.6" "545.4" "534.6" "543.9" "552.4" "525.8" "566.3" "557.3" "544.3" "470.9" "" "" "" "" "" "" "" "" "" "" "491.4" "441.3" "483.6" "530.9" "455.9" "525.8" "424.1" "492.2" "487.0" "168.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8303204193391828869" "False" "High" "IsMasterProtein" "Q8WUI4" "Histone deacetylase 7 OS=Homo sapiens OX=9606 GN=HDAC7 PE=1 SV=2" "0.000" "False" "46.574" "19" "15" "15" "15" "952" "102.9" "7.58" "56.88" "15" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00850" "51564" "ENSG00000061273" "HDAC7" "B3KY08; B4DWI0; B4E0Q5; hsa:51564; Q6P1W9; Q6W9G7; Q7Z4K2; Q7Z5I1; Q8WUI4; Q96K01; Q9BR73; Q9H7L0; Q9NW41; Q9NWA9; Q9NYK9; Q9UFU7" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Gastrin signaling pathway" "SUMOylation of DNA damage response and repair proteins; Regulation of PTEN gene transcription; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "13" "0" "1.003" "0.943" "0.990" "0.989" "0.951" "1.049" "1.040" "0.967" "1.021" "976.6" "979.6" "921.0" "966.7" "965.4" "929.2" "1024.5" "1016.1" "944.3" "997.0" "" "" "" "" "" "" "" "" "" "" "878.1" "792.7" "833.1" "943.6" "796.7" "929.2" "767.1" "897.4" "844.9" "355.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4066776278631376418" "False" "High" "IsMasterProtein" "P17612" "cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens OX=9606 GN=PRKACA PE=1 SV=2" "0.000" "False" "46.548" "38" "12" "18" "5" "351" "40.6" "8.79" "61.29" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5566" "ENSG00000072062; ENSG00000288516" "PRKACA" "hsa:5566; P17612; Q32P54; Q9H2Y0; Q9NRB4; Q9NRH9" "Nicotine effect on dopaminergic neurons; Sterol regulatory element-binding proteins (SREBP) signaling; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Dopamine metabolism; Common pathways underlying drug addiction; Complement system; Mesodermal commitment pathway; IL-3 signaling pathway; Myometrial relaxation and contraction pathways; Mesodermal commitment pathway; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Lipid metabolism pathway; Phosphodiesterases in neuronal function; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; GDNF signaling; Urotensin-II-mediated signaling pathway; Calcium regulation in cardiac cells; KCNQ2-related epilepsies; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Regulation of PLK1 Activity at G2/M Transition; FCGR3A-mediated IL10 synthesis; Triglyceride catabolism; Recruitment of NuMA to mitotic centrosomes; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Ion homeostasis; Interleukin-3, Interleukin-5 and GM-CSF signaling; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Mitochondrial protein degradation; Regulation of MECP2 expression and activity; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; Loss of phosphorylation of MECP2 at T308; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "75" "4" "1.149" "1.078" "1.055" "1.173" "1.088" "1.088" "1.176" "1.177" "1.112" "1505.3" "1729.8" "1622.8" "1587.4" "1765.3" "1637.7" "1638.1" "1770.3" "1771.5" "1673.9" "" "" "" "" "" "" "" "" "" "" "1353.4" "1399.7" "1467.9" "1549.5" "1456.7" "1637.7" "1226.6" "1563.6" "1585.1" "597.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9134922039646345365" "False" "High" "IsMasterProtein" "Q8NBF2" "NHL repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=NHLRC2 PE=1 SV=1" "0.000" "False" "46.500" "21" "12" "14" "12" "726" "79.4" "5.55" "52.19" "12" "" "non-structural extracellular;cytosol;other cell component" "" "Pf01436, Pf13905" "374354" "ENSG00000196865" "NHLRC2" "hsa:374354; Q8N1H1; Q8N5A6; Q8NBF2" "" "Platelet degranulation" "1" "0" "1.064" "0.972" "0.962" "1.009" "0.947" "1.089" "0.932" "0.966" "1.146" "771.0" "820.1" "749.1" "741.4" "778.2" "730.1" "840.0" "718.8" "745.0" "883.2" "" "" "" "" "" "" "" "" "" "" "693.2" "663.6" "677.6" "723.7" "642.2" "730.1" "628.9" "634.9" "666.6" "315.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5967874803311728941" "False" "High" "IsMasterProtein" "Q9UBP0" "Spastin OS=Homo sapiens OX=9606 GN=SPAST PE=1 SV=1" "0.000" "False" "46.422" "27" "13" "15" "13" "616" "67.2" "9.64" "56.26" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862" "6683" "ENSG00000021574" "SPAST" "A7E2A7; hsa:6683; Q9UBP0; Q9UPR9" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "0" "1.010" "1.005" "1.033" "0.978" "1.049" "1.085" "1.020" "1.022" "1.178" "1120.6" "1132.1" "1125.7" "1158.0" "1096.5" "1175.9" "1215.7" "1143.4" "1145.3" "1320.2" "" "" "" "" "" "" "" "" "" "" "1007.5" "916.1" "1018.2" "1130.4" "904.8" "1175.9" "910.3" "1009.9" "1024.8" "471.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779852501093026521" "False" "High" "IsMasterProtein" "P15153" "Ras-related C3 botulinum toxin substrate 2 OS=Homo sapiens OX=9606 GN=RAC2 PE=1 SV=1" "0.000" "False" "46.408" "48" "11" "39" "6" "192" "21.4" "7.61" "135.63" "11" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5880" "ENSG00000128340" "RAC2" "hsa:5880; P15153; Q9UDJ4" "Integrin-mediated cell adhesion; RalA downstream regulated genes; B cell receptor signaling pathway; Focal adhesion; MAPK signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Macrophage markers; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Insulin signaling; Regulation of actin cytoskeleton; Pathways in cancer; DNA damage response (only ATM dependent)" "RAC2 GTPase cycle; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; PCP/CE pathway; ROS and RNS production in phagocytes; RHO GTPases Activate NADPH Oxidases" "24" "5" "0.975" "0.974" "1.050" "0.958" "1.022" "0.956" "0.972" "0.932" "0.760" "3433.4" "3348.6" "3344.2" "3606.6" "3289.8" "3507.7" "3283.9" "3337.1" "3200.5" "2609.9" "" "" "" "" "" "" "" "" "" "" "3087.0" "2709.6" "3025.0" "3520.5" "2714.8" "3507.7" "2458.9" "2947.6" "2863.8" "931.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072091565905259276" "False" "High" "IsMasterProtein" "P42574" "Caspase-3 OS=Homo sapiens OX=9606 GN=CASP3 PE=1 SV=2" "0.000" "False" "46.405" "30" "7" "16" "6" "277" "31.6" "6.54" "60.47" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00656" "836" "ENSG00000164305" "CASP3" "A8K5M2; D3DP53; hsa:836; P42574; Q96AN1; Q96KP2" "miRNA regulation of DNA damage response; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Spinal cord injury; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Copper homeostasis; Hepatitis C and hepatocellular carcinoma; MAPK signaling pathway; Apoptosis modulation by HSP70; ERK pathway in Huntington's disease; Oxidative damage response; miRNA regulation of p53 pathway in prostate cancer; Prion disease pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; MTHFR deficiency; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Peroxiredoxin 2 induced ovarian failure; Complement system in neuronal development and plasticity; Orexin receptor pathway; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; IL-26 signaling pathways; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response" "Degradation of the extracellular matrix; Apoptosis induced DNA fragmentation; Signaling by Hippo; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Caspase activation via Dependence Receptors in the absence of ligand; Pyroptosis; Caspase-mediated cleavage of cytoskeletal proteins; NADE modulates death signalling; Other interleukin signaling; Apoptotic cleavage of cell adhesion proteins; Stimulation of the cell death response by PAK-2p34" "60" "0" "1.138" "1.111" "1.027" "1.155" "1.210" "1.172" "1.114" "1.131" "0.896" "1111.7" "1265.0" "1235.3" "1142.2" "1284.3" "1345.2" "1303.0" "1238.6" "1257.6" "995.8" "" "" "" "" "" "" "" "" "" "" "999.5" "1023.6" "1117.4" "1114.9" "1059.8" "1345.2" "975.7" "1094.0" "1125.3" "355.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "567113707807287491" "False" "High" "IsMasterProtein" "Q8NBT2" "Kinetochore protein Spc24 OS=Homo sapiens OX=9606 GN=SPC24 PE=1 SV=3" "0.000" "False" "46.355" "58" "8" "16" "8" "197" "22.4" "4.70" "62.59" "8" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08286" "147841" "ENSG00000161888" "SPC24" "B4DZZ7; C9JGC4; hsa:147841; Q8NBT2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.966" "1.011" "0.960" "1.066" "0.969" "0.988" "0.990" "1.050" "1.320" "742.1" "716.7" "750.6" "712.6" "791.1" "719.1" "733.5" "734.9" "779.0" "979.9" "" "" "" "" "" "" "" "" "" "" "667.2" "580.0" "678.9" "695.6" "652.8" "719.1" "549.2" "649.1" "697.1" "349.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4853611610042411436" "False" "High" "IsMasterProtein" "Q04760" "Lactoylglutathione lyase OS=Homo sapiens OX=9606 GN=GLO1 PE=1 SV=4" "0.000" "False" "46.290" "46" "9" "27" "9" "184" "20.8" "5.31" "86.64" "9" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00903" "2739" "ENSG00000124767" "GLO1" "B2R6P7; B4DDV0; hsa:2739; P78375; Q04760; Q59EL0; Q5TZW3; Q96FC0; Q96J41" "" "Pyruvate metabolism" "1" "0" "0.950" "0.952" "0.941" "0.984" "0.985" "0.969" "0.997" "0.974" "0.766" "2875.2" "2732.4" "2737.2" "2704.6" "2830.5" "2831.4" "2784.8" "2867.8" "2800.9" "2202.6" "" "" "" "" "" "" "" "" "" "" "2585.1" "2210.9" "2475.9" "2640.1" "2335.8" "2831.4" "2085.2" "2533.1" "2506.2" "786.3" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2614245215378921803" "False" "High" "IsMasterProtein" "Q9UBU8" "Mortality factor 4-like protein 1 OS=Homo sapiens OX=9606 GN=MORF4L1 PE=1 SV=2" "0.000" "False" "46.261" "27" "9" "16" "7" "362" "41.4" "9.28" "55.35" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05712, Pf11717" "10933" "ENSG00000185787" "MORF4L1" "B4DKN6; B7Z6R1; D3DW88; hsa:10933; O95899; Q5QTS1; Q6NVX8; Q86YT7; Q9HBP6; Q9NSW5; Q9UBU8" "Pathways affected in adenoid cystic carcinoma" "HATs acetylate histones" "2" "2" "0.937" "1.049" "0.974" "0.951" "0.961" "0.918" "0.981" "1.005" "1.132" "1213.7" "1137.0" "1272.9" "1182.1" "1154.6" "1165.8" "1113.6" "1190.4" "1220.2" "1374.3" "" "" "" "" "" "" "" "" "" "" "1091.2" "920.0" "1151.4" "1153.9" "952.8" "1165.8" "833.8" "1051.4" "1091.8" "490.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004494409327660908" "False" "High" "IsMasterProtein" "P07205" "Phosphoglycerate kinase 2 OS=Homo sapiens OX=9606 GN=PGK2 PE=1 SV=3" "0.000" "False" "46.241" "21" "8" "48" "2" "417" "44.8" "8.54" "159.22" "8" "other metabolic processes;other biological processes" "cytosol;cytoskeleton" "kinase activity;other molecular function" "Pf00162" "5232" "ENSG00000170950" "PGK2" "B2R6Y8; hsa:5232; P07205; Q9H107" "Cori cycle; Clear cell renal cell carcinoma pathways; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Glycolysis; Gluconeogenesis" "6" "0" "0.982" "0.964" "0.981" "1.011" "0.860" "0.944" "1.004" "0.994" "0.886" "595.0" "584.2" "573.2" "583.9" "601.7" "511.4" "561.9" "597.4" "591.1" "527.0" "" "" "" "" "" "" "" "" "" "" "534.9" "472.7" "518.5" "570.0" "496.5" "511.4" "420.7" "527.6" "529.0" "188.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755202633810832906" "False" "High" "IsMasterProtein" "Q9C0I1" "Myotubularin-related protein 12 OS=Homo sapiens OX=9606 GN=MTMR12 PE=1 SV=2" "0.000" "False" "46.240" "19" "13" "17" "13" "747" "86.1" "6.62" "56.14" "13" "" "cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf06602, Pf12578" "54545" "ENSG00000150712" "MTMR12" "hsa:54545; Q69YJ4; Q6PFW3; Q96QU2; Q9C0I1; Q9NX27" "" "Synthesis of PIPs at the early endosome membrane" "1" "0" "1.047" "1.032" "1.011" "1.010" "0.983" "0.988" "1.053" "1.036" "0.894" "1756.8" "1838.6" "1813.8" "1776.5" "1775.3" "1726.3" "1735.9" "1850.0" "1820.4" "1570.8" "" "" "" "" "" "" "" "" "" "" "1579.5" "1487.7" "1640.6" "1734.1" "1465.0" "1726.3" "1299.8" "1634.1" "1628.9" "560.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216931438576770944" "False" "High" "IsMasterProtein" "Q9UK76" "Jupiter microtubule associated homolog 1 OS=Homo sapiens OX=9606 GN=JPT1 PE=1 SV=3" "0.000" "False" "46.221" "37" "4" "20" "4" "154" "16.0" "5.60" "98.09" "4" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf17054" "51155" "ENSG00000189159" "JPT1" "B2R6K3; hsa:51155; Q53FG7; Q7Z2D2; Q7Z2F0; Q9UK76" "" "" "0" "0" "0.965" "0.866" "0.912" "0.963" "0.961" "0.960" "1.021" "0.908" "0.810" "1840.9" "1776.6" "1594.6" "1679.0" "1771.9" "1770.0" "1767.5" "1880.3" "1672.1" "1490.6" "" "" "" "" "" "" "" "" "" "" "1655.2" "1437.5" "1442.4" "1639.0" "1462.2" "1770.0" "1323.4" "1660.8" "1496.2" "532.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3549591940651771702" "False" "High" "IsMasterProtein" "P17252" "Protein kinase C alpha type OS=Homo sapiens OX=9606 GN=PRKCA PE=1 SV=4" "0.000" "False" "46.155" "22" "13" "16" "8" "672" "76.7" "7.05" "53.23" "13" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5578" "ENSG00000154229" "PRKCA" "B5BU22; hsa:5578; P17252; Q15137; Q32M72; Q96RE4" "Target of rapamycin signaling; Thyroxine (thyroid hormone) production; Follicle stimulating hormone (FSH) signaling pathway; Microtubule cytoskeleton regulation; Endothelin pathways; Glioblastoma signaling pathways; Pathogenic Escherichia coli infection; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Spinal cord injury; Alpha 6 beta 4 signaling pathway; T cell receptor and co-stimulatory signaling; Common pathways underlying drug addiction; Cardiac hypertrophic response; Complement system; Myometrial relaxation and contraction pathways; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Melatonin metabolism and effects; G protein signaling pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Ras signaling; Non-small cell lung cancer; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Fragile X syndrome; Overview of interferons-mediated signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Hippocampal synaptogenesis and neurogenesis; Chronic hyperglycemia impairment of neuron function; TROP2 regulatory signaling; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; Osteoarthritic chondrocyte hypertrophy; ErbB signaling pathway" "G alpha (z) signalling events; Disinhibition of SNARE formation; RET signaling; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; Ca2+ pathway; WNT5A-dependent internalization of FZD4; Inactivation, recovery and regulation of the phototransduction cascade; Syndecan interactions; HuR (ELAVL1) binds and stabilizes mRNA; VEGFR2 mediated cell proliferation; Trafficking of GluR2-containing AMPA receptors; Depolymerization of the Nuclear Lamina; Acetylcholine regulates insulin secretion; EGFR Transactivation by Gastrin; RHO GTPases Activate NADPH Oxidases; Calmodulin induced events; ROBO receptors bind AKAP5" "75" "3" "0.999" "0.899" "0.981" "0.962" "0.893" "0.991" "0.960" "1.010" "0.945" "1299.5" "1298.1" "1168.4" "1275.2" "1250.6" "1160.1" "1287.7" "1247.8" "1312.4" "1228.4" "" "" "" "" "" "" "" "" "" "" "1168.3" "1050.4" "1056.9" "1244.8" "1032.0" "1160.1" "964.2" "1102.1" "1174.3" "438.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3157784244312675539" "False" "High" "IsMasterProtein" "Q9UKD2" "mRNA turnover protein 4 homolog OS=Homo sapiens OX=9606 GN=MRTO4 PE=1 SV=2" "0.000" "False" "46.154" "41" "11" "20" "11" "239" "27.5" "8.29" "54.60" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00466, Pf17777" "51154" "ENSG00000053372" "MRTO4" "B3KNB3; hsa:51154; Q5TG55; Q96SS6; Q9BPV9; Q9UKD2" "" "" "0" "0" "0.981" "0.937" "0.980" "1.077" "0.876" "1.023" "1.057" "0.875" "0.982" "2206.6" "2165.2" "2068.3" "2162.9" "2376.9" "1932.2" "2257.5" "2332.6" "1931.1" "2166.7" "" "" "" "" "" "" "" "" "" "" "1984.0" "1752.0" "1870.9" "2111.3" "1961.5" "1932.2" "1690.3" "2060.3" "1727.9" "773.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3659608677254824690" "False" "High" "IsMasterProtein" "P53582" "Methionine aminopeptidase 1 OS=Homo sapiens OX=9606 GN=METAP1 PE=1 SV=2" "0.000" "False" "46.151" "32" "9" "17" "9" "386" "43.2" "7.17" "67.12" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00557, Pf15801" "23173" "ENSG00000164024" "METAP1" "B4E2E6; hsa:23173; P53582" "" "Inactivation, recovery and regulation of the phototransduction cascade" "1" "0" "1.099" "1.150" "1.125" "1.123" "1.195" "1.173" "1.051" "1.127" "1.822" "1215.5" "1336.1" "1397.7" "1367.4" "1364.6" "1452.7" "1425.8" "1277.8" "1369.4" "2215.0" "" "" "" "" "" "" "" "" "" "" "1092.9" "1081.1" "1264.3" "1334.8" "1126.1" "1452.7" "1067.6" "1128.6" "1225.4" "790.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7866800410965669169" "False" "High" "IsMasterProtein" "Q9H0G5" "Nuclear speckle splicing regulatory protein 1 OS=Homo sapiens OX=9606 GN=NSRP1 PE=1 SV=1" "0.000" "False" "46.143" "24" "13" "14" "13" "558" "66.4" "8.84" "56.95" "13" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09745, Pf20427" "84081" "ENSG00000126653" "NSRP1" "hsa:84081; Q6FI71; Q9H0G5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.894" "0.962" "0.918" "0.937" "1.049" "0.879" "0.973" "0.953" "0.812" "1581.2" "1414.1" "1521.3" "1452.0" "1482.0" "1658.4" "1390.4" "1539.0" "1507.1" "1284.1" "" "" "" "" "" "" "" "" "" "" "1421.6" "1144.3" "1376.1" "1417.3" "1222.9" "1658.4" "1041.1" "1359.3" "1348.5" "458.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2725190465399901470" "False" "High" "IsMasterProtein" "P62829" "Large ribosomal subunit protein uL14 OS=Homo sapiens OX=9606 GN=RPL23 PE=1 SV=1" "0.000" "False" "46.114" "69" "9" "21" "9" "140" "14.9" "10.51" "75.46" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00238" "9349" "ENSG00000125691" "RPL23" "hsa:9349; P23131; P24048; P62829; Q29246; Q3SWV7; Q6P5S1" "Cytoplasmic ribosomal proteins; 17q12 copy number variation syndrome" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.979" "0.979" "0.983" "1.007" "0.982" "1.016" "1.002" "1.022" "0.983" "1616.5" "1582.7" "1582.5" "1588.6" "1627.8" "1587.7" "1641.6" "1619.7" "1651.6" "1589.0" "" "" "" "" "" "" "" "" "" "" "1453.4" "1280.7" "1431.4" "1550.7" "1343.3" "1587.7" "1229.2" "1430.6" "1477.8" "567.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5491649820020093575" "False" "High" "IsMasterProtein" "Q9H4B7" "Tubulin beta-1 chain OS=Homo sapiens OX=9606 GN=TUBB1 PE=1 SV=1" "0.000" "False" "46.110" "13" "8" "63" "2" "451" "50.3" "5.17" "180.60" "8" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "81027" "ENSG00000101162" "TUBB1" "hsa:81027; Q9H4B7" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Intraflagellar transport; Recruitment of NuMA to mitotic centrosomes; Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling; Prefoldin mediated transfer of substrate to CCT/TriC; Hedgehog 'off' state" "35" "0" "0.966" "0.931" "0.885" "1.015" "0.792" "0.968" "0.869" "0.849" "1.008" "252.5" "243.8" "235.1" "223.6" "256.3" "199.9" "244.5" "219.5" "214.3" "254.6" "" "" "" "" "" "" "" "" "" "" "227.0" "197.3" "212.7" "218.2" "211.5" "199.9" "183.1" "193.9" "191.7" "90.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579275288277334412" "False" "High" "IsMasterProtein" "P46736" "Lys-63-specific deubiquitinase BRCC36 OS=Homo sapiens OX=9606 GN=BRCC3 PE=1 SV=2" "0.000" "False" "46.027" "33" "9" "17" "9" "316" "36.0" "5.92" "64.49" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01398, Pf18110" "79184" "ENSG00000185515" "BRCC3" "A6QRF8; A6QRF9; A8MUX5; A8MWH0; A9Z1Y0; A9Z1Y5; B1B062; B4DQN7; hsa:79184; P46736; Q16107; Q53YX5; Q9BTZ6" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ); Metalloprotease DUBs" "6" "0" "1.052" "1.020" "1.014" "1.075" "0.987" "1.039" "1.016" "1.005" "0.873" "973.4" "1024.3" "993.3" "987.5" "1046.1" "960.3" "1011.2" "988.6" "978.7" "849.3" "" "" "" "" "" "" "" "" "" "" "875.2" "828.8" "898.4" "963.9" "863.2" "960.3" "757.2" "873.2" "875.7" "303.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5468856902780976606" "False" "High" "IsMasterProtein" "O60884" "DnaJ homolog subfamily A member 2 OS=Homo sapiens OX=9606 GN=DNAJA2 PE=1 SV=1" "0.000" "False" "46.008" "28" "12" "21" "12" "412" "45.7" "6.48" "65.00" "12" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf00226, Pf00684, Pf01556" "10294" "ENSG00000069345" "DNAJA2" "B2R7L7; hsa:10294; O14711; O60884" "" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand" "1" "0" "0.937" "0.967" "0.990" "0.915" "0.945" "0.963" "0.963" "0.956" "1.350" "1517.4" "1421.6" "1467.8" "1502.5" "1389.1" "1433.9" "1461.1" "1461.0" "1450.4" "2048.2" "" "" "" "" "" "" "" "" "" "" "1364.3" "1150.3" "1327.7" "1466.7" "1146.3" "1433.9" "1094.1" "1290.4" "1297.8" "731.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285089334394207834" "False" "High" "IsMasterProtein" "Q12959" "Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2" "0.000" "False" "45.987" "17" "14" "16" "10" "904" "100.4" "5.76" "52.11" "14" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf09058, Pf10600, Pf10608" "1739" "ENSG00000075711" "DLG1" "A5YKK7; B4DGU1; B4DGZ8; B7ZMM0; B9EIQ5; D3DXB8; D3DXB9; E7EWL7; E9PG21; hsa:1739; Q12958; Q12959" "Brain-derived neurotrophic factor (BDNF) signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Disruption of postsynaptic signaling by CNV; 3q29 copy number variation syndrome; Cell lineage map for neuronal differentiation" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "15" "2" "0.977" "0.956" "1.017" "1.028" "0.959" "1.039" "0.958" "0.947" "0.994" "877.2" "856.8" "838.3" "891.9" "901.4" "841.6" "911.4" "840.1" "830.5" "871.8" "" "" "" "" "" "" "" "" "" "" "788.7" "693.3" "758.3" "870.7" "743.8" "841.6" "682.4" "742.0" "743.1" "311.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6603036499622523787" "False" "High" "IsMasterProtein" "Q9Y2S7" "Polymerase delta-interacting protein 2 OS=Homo sapiens OX=9606 GN=POLDIP2 PE=1 SV=1" "0.000" "False" "45.969" "39" "13" "20" "13" "368" "42.0" "8.63" "64.43" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04379, Pf08755" "26073" "ENSG00000004142" "POLDIP2" "B2R846; hsa:26073; Q96JE4; Q9Y2S7" "" "" "0" "0" "1.063" "1.011" "1.014" "1.200" "0.975" "1.072" "0.993" "1.074" "0.990" "955.4" "1015.2" "966.4" "968.6" "1146.9" "931.3" "1024.3" "948.6" "1026.2" "945.6" "" "" "" "" "" "" "" "" "" "" "859.0" "821.5" "874.2" "945.5" "946.5" "931.3" "767.0" "837.8" "918.2" "337.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302134313779443403" "False" "High" "IsMasterProtein" "Q96ER3" "Protein SAAL1 OS=Homo sapiens OX=9606 GN=SAAL1 PE=1 SV=2" "0.000" "False" "45.947" "32" "13" "19" "13" "474" "53.5" "4.50" "70.27" "13" "other biological processes" "nucleus" "" "" "113174" "ENSG00000166788" "SAAL1" "A6NH05; hsa:113174; Q96ER3" "" "" "0" "0" "1.026" "0.995" "0.997" "1.015" "1.002" "1.061" "1.000" "0.999" "1.162" "1758.5" "1805.1" "1749.7" "1753.9" "1784.6" "1761.6" "1865.5" "1758.7" "1756.4" "2042.8" "" "" "" "" "" "" "" "" "" "" "1581.1" "1460.6" "1582.6" "1712.0" "1472.7" "1761.6" "1396.9" "1553.4" "1571.6" "729.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-630716066930521994" "False" "High" "IsMasterProtein" "P55957" "BH3-interacting domain death agonist OS=Homo sapiens OX=9606 GN=BID PE=1 SV=1" "0.000" "False" "45.944" "47" "6" "20" "6" "195" "22.0" "5.44" "76.55" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf06393" "637" "ENSG00000015475" "BID" "hsa:637; P55957; Q549M7; Q71T04; Q7Z4M9; Q8IY86" "miRNA regulation of DNA damage response; TP53 network; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Apoptosis modulation by HSP70; Regulation of apoptosis by parathyroid hormone-related protein; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Nonalcoholic fatty liver disease; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Complement system in neuronal development and plasticity; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; DNA damage response" "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation, myristolyation of BID and translocation to mitochondria; Activation of BAD and translocation to mitochondria ; Activation and oligomerization of BAK protein; Activation, translocation and oligomerization of BAX" "30" "0" "0.990" "1.074" "0.982" "1.044" "1.007" "0.975" "0.990" "1.022" "0.924" "763.5" "755.7" "819.8" "749.6" "797.3" "768.8" "744.3" "755.7" "780.1" "705.2" "" "" "" "" "" "" "" "" "" "" "686.4" "611.5" "741.5" "731.7" "657.9" "768.8" "557.3" "667.5" "698.0" "251.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6990414283188081585" "False" "High" "IsMasterProtein" "O43660" "Pleiotropic regulator 1 OS=Homo sapiens OX=9606 GN=PLRG1 PE=1 SV=1" "0.000" "False" "45.929" "29" "12" "13" "12" "514" "57.2" "9.17" "55.57" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "5356" "ENSG00000171566" "PLRG1" "B3KMK4; hsa:5356; O43660; Q3KQY5; Q8WUD8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.940" "1.021" "1.017" "1.043" "1.054" "0.918" "0.873" "1.045" "0.983" "863.6" "811.7" "881.4" "878.6" "900.4" "910.7" "792.9" "754.0" "902.9" "848.7" "" "" "" "" "" "" "" "" "" "" "776.5" "656.8" "797.2" "857.7" "743.0" "910.7" "593.7" "666.0" "807.9" "303.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3076278996676727483" "False" "High" "IsMasterProtein" "P53350" "Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1" "0.000" "False" "45.906" "26" "14" "15" "14" "603" "68.2" "8.91" "54.67" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00659" "5347" "ENSG00000166851" "PLK1" "hsa:5347; P53350; Q15153; Q99746" "Cell cycle; Integrated cancer pathway; Androgen receptor network in prostate cancer; TNF-alpha signaling pathway; 22q11.2 copy number variation syndrome; Cohesin complex - Cornelia de Lange syndrome" "The role of GTSE1 in G2/M progression after G2 checkpoint; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Phosphorylation of the APC/C; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Polo-like kinase mediated events; Activation of NIMA Kinases NEK9, NEK6, NEK7; Mitotic Telophase/Cytokinesis; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "30" "0" "1.033" "1.062" "0.934" "0.995" "1.057" "0.945" "0.957" "1.074" "0.985" "1086.2" "1121.5" "1154.1" "1015.0" "1080.6" "1148.2" "1026.4" "1039.9" "1166.7" "1069.9" "" "" "" "" "" "" "" "" "" "" "976.6" "907.5" "1043.9" "990.8" "891.7" "1148.2" "768.5" "918.5" "1043.9" "381.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6100821946699504428" "False" "High" "IsMasterProtein" "Q5QNW6" "Histone H2B type 2-F OS=Homo sapiens OX=9606 GN=H2BC18 PE=1 SV=3" "0.000" "False" "45.854" "41" "6" "33" "2" "126" "13.9" "10.32" "121.05" "6" "" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "440689" "ENSG00000203814" "H2BC18" "A8K0U9; B4DLA9; hsa:440689; Q5QNW6" "" "HCMV Late Events; HCMV Early Events; Ub-specific processing proteases; HDACs deacetylate histones; HATs acetylate histones" "5" "0" "0.813" "0.800" "1.003" "0.896" "0.881" "0.750" "0.936" "0.838" "1.090" "900.5" "732.5" "720.0" "903.3" "807.0" "793.7" "675.7" "842.7" "754.7" "981.7" "" "" "" "" "" "" "" "" "" "" "809.6" "592.7" "651.2" "881.7" "665.9" "793.7" "506.0" "744.3" "675.3" "350.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8722067118007621165" "False" "High" "IsMasterProtein" "P23497" "Nuclear autoantigen Sp-100 OS=Homo sapiens OX=9606 GN=SP100 PE=1 SV=3" "0.000" "False" "45.820" "14" "13" "26" "6" "879" "100.4" "8.22" "82.02" "13" "cell organization and biogenesis;DNA metabolism;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf01342, Pf03172, Pf09011" "6672" "ENSG00000067066" "SP100" "B4DDX5; B8ZZD8; E7EUA7; E9PH61; F8WFE2; hsa:6672; O75450; P23497; Q13343; Q8TE34; Q96F70; Q96T24; Q96T95; Q9NP33; Q9UE32" "" "SUMOylation of DNA damage response and repair proteins; Interferon gamma signaling" "2" "3" "0.923" "0.946" "0.967" "0.988" "0.935" "0.987" "1.006" "0.988" "0.948" "1780.0" "1642.7" "1684.4" "1721.4" "1758.7" "1664.8" "1756.1" "1790.5" "1758.7" "1687.8" "" "" "" "" "" "" "" "" "" "" "1600.4" "1329.2" "1523.6" "1680.4" "1451.3" "1664.8" "1315.0" "1581.5" "1573.7" "602.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6265096555801149049" "False" "High" "IsMasterProtein" "P06132" "Uroporphyrinogen decarboxylase OS=Homo sapiens OX=9606 GN=UROD PE=1 SV=2" "0.000" "False" "45.800" "25" "7" "15" "7" "367" "40.8" "6.14" "62.47" "7" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01208" "7389" "ENSG00000126088" "UROD" "A8K762; hsa:7389; P06132; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.033" "1.006" "0.970" "1.093" "1.097" "1.013" "1.008" "1.062" "0.875" "941.9" "972.6" "947.7" "913.4" "1029.9" "1033.5" "953.8" "949.3" "999.9" "824.1" "" "" "" "" "" "" "" "" "" "" "846.8" "787.0" "857.2" "891.6" "849.9" "1033.5" "714.2" "838.5" "894.7" "294.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2928934229844812076" "False" "High" "IsMasterProtein" "Q8TCD5" "5'(3')-deoxyribonucleotidase, cytosolic type OS=Homo sapiens OX=9606 GN=NT5C PE=1 SV=2" "0.000" "False" "45.791" "50" "9" "16" "9" "201" "23.4" "6.64" "59.21" "9" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06941" "30833" "ENSG00000125458" "NT5C" "hsa:30833; Q8TCD5; Q96HS6; Q9NP82" "Pyrimidine metabolism" "Purine catabolism; Pyrimidine catabolism" "3" "0" "1.067" "1.015" "1.046" "1.061" "1.026" "1.089" "1.073" "1.038" "0.876" "983.0" "1048.8" "997.7" "1028.5" "1042.6" "1008.7" "1070.0" "1055.0" "1020.3" "860.7" "" "" "" "" "" "" "" "" "" "" "883.8" "848.7" "902.4" "1004.0" "860.4" "1008.7" "801.2" "931.9" "912.9" "307.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1560013588739463450" "False" "High" "IsMasterProtein" "Q9H7D7" "WD repeat-containing protein 26 OS=Homo sapiens OX=9606 GN=WDR26 PE=1 SV=3" "0.000" "False" "45.788" "21" "12" "16" "12" "661" "72.1" "6.16" "54.31" "12" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400, Pf17814" "80232" "ENSG00000162923" "WDR26" "A0MNN3; hsa:80232; Q4G100; Q59EC4; Q5GLZ9; Q86UY4; Q9H3C2; Q9H7D7" "Ciliary landscape" "" "1" "0" "1.001" "1.009" "0.958" "0.991" "0.994" "0.953" "0.964" "1.055" "0.951" "831.6" "832.3" "838.9" "796.6" "824.0" "826.3" "792.3" "801.5" "877.4" "790.7" "" "" "" "" "" "" "" "" "" "" "747.7" "673.5" "758.8" "777.6" "680.0" "826.3" "593.3" "707.9" "785.1" "282.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8881976693439910842" "False" "High" "IsMasterProtein" "P40306" "Proteasome subunit beta type-10 OS=Homo sapiens OX=9606 GN=PSMB10 PE=1 SV=1" "0.000" "False" "45.743" "39" "10" "14" "10" "273" "28.9" "7.81" "56.81" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227, Pf12465" "5699" "ENSG00000205220" "PSMB10" "B2R5J4; hsa:5699; P40306; Q5U098" "Proteasome degradation" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; FCERI mediated NF-kB activation; Downstream TCR signaling; Regulation of RAS by GAPs; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "60" "0" "1.083" "1.087" "0.989" "1.044" "1.053" "1.085" "1.026" "1.049" "0.897" "805.9" "872.8" "875.9" "797.0" "841.1" "848.5" "874.7" "827.2" "845.4" "723.3" "" "" "" "" "" "" "" "" "" "" "724.6" "706.2" "792.2" "778.0" "694.1" "848.5" "654.9" "730.7" "756.5" "258.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3652671627369165893" "False" "High" "IsMasterProtein" "Q9HBM1" "Kinetochore protein Spc25 OS=Homo sapiens OX=9606 GN=SPC25 PE=1 SV=1" "0.000" "False" "45.723" "46" "9" "17" "9" "224" "26.1" "8.00" "71.74" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf08234" "57405" "ENSG00000152253; ENSG00000277909" "SPC25" "A8K4X8; D3DPC0; hsa:57405; Q9HBM1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.065" "1.059" "1.032" "1.086" "1.037" "0.989" "1.033" "1.048" "1.330" "1033.3" "1100.1" "1093.8" "1065.9" "1122.0" "1071.1" "1021.5" "1067.4" "1082.7" "1374.4" "" "" "" "" "" "" "" "" "" "" "929.0" "890.1" "989.4" "1040.5" "925.9" "1071.1" "764.9" "942.8" "968.8" "490.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4248741172720899665" "False" "High" "IsMasterProtein" "P62304" "Small nuclear ribonucleoprotein E OS=Homo sapiens OX=9606 GN=SNRPE PE=1 SV=1" "0.000" "False" "45.677" "70" "5" "22" "5" "92" "10.8" "9.44" "86.48" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6635" "ENSG00000182004" "SNRPE" "B2R5B9; hsa:6635; P08578; P62304; Q15498; Q5BKT2" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.048" "1.164" "0.968" "1.213" "1.218" "1.108" "1.066" "1.227" "0.983" "1403.2" "1471.1" "1633.2" "1357.8" "1702.1" "1708.7" "1555.1" "1496.3" "1722.4" "1379.0" "" "" "" "" "" "" "" "" "" "" "1261.6" "1190.3" "1477.3" "1325.4" "1404.6" "1708.7" "1164.4" "1321.6" "1541.2" "492.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4323933511445947970" "False" "High" "IsMasterProtein" "P43405" "Tyrosine-protein kinase SYK OS=Homo sapiens OX=9606 GN=SYK PE=1 SV=1" "0.000" "False" "45.652" "20" "11" "18" "11" "635" "72.0" "8.25" "72.36" "11" "cell adhesion;cell-cell signaling;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf07714" "6850" "ENSG00000165025" "SYK" "hsa:6850; P43405" "IL-5 signaling pathway; RANKL/RANK signaling pathway; B cell receptor signaling pathway; IL-3 signaling pathway; Microglia pathogen phagocytosis pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; IL-2 signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Potential therapeutics for SARS; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; CLEC7A (Dectin-1) signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; DAP12 signaling; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Integrin signaling; Interleukin-2 signaling; Dectin-2 family; FLT3 signaling through SRC family kinases" "30" "0" "1.073" "1.095" "1.035" "1.022" "1.032" "1.108" "0.988" "1.067" "4.186" "927.7" "995.6" "1015.8" "959.8" "948.5" "957.8" "1027.4" "916.4" "990.0" "3883.2" "" "" "" "" "" "" "" "" "" "" "834.1" "805.6" "918.9" "936.9" "782.7" "957.8" "769.3" "809.4" "885.9" "1386.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6825792350743248999" "False" "High" "IsMasterProtein" "P07738" "Bisphosphoglycerate mutase OS=Homo sapiens OX=9606 GN=BPGM PE=1 SV=2" "0.000" "False" "45.566" "34" "9" "16" "9" "259" "30.0" "6.54" "62.23" "9" "other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol" "other molecular function" "Pf00300" "669" "ENSG00000172331" "BPGM" "A4D1N9; hsa:669; P07738" "IL-18 signaling pathway" "Glycolysis" "2" "0" "0.983" "1.018" "0.955" "1.018" "0.950" "1.005" "0.987" "0.966" "0.750" "1448.1" "1424.1" "1474.3" "1383.5" "1474.7" "1375.0" "1454.9" "1428.6" "1399.4" "1086.6" "" "" "" "" "" "" "" "" "" "" "1302.0" "1152.4" "1333.6" "1350.4" "1216.9" "1375.0" "1089.4" "1261.9" "1252.2" "387.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779447610884953183" "False" "High" "IsMasterProtein" "Q9NPD8" "Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens OX=9606 GN=UBE2T PE=1 SV=1" "0.000" "False" "45.562" "48" "8" "17" "8" "197" "22.5" "7.99" "60.48" "8" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf00179" "29089" "ENSG00000077152" "UBE2T" "hsa:29089; Q2TU36; Q9NPD8" "Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Fanconi Anemia Pathway" "3" "0" "1.006" "1.097" "1.006" "1.018" "1.102" "1.009" "1.017" "1.059" "1.082" "1198.1" "1205.9" "1314.2" "1205.3" "1219.4" "1319.9" "1208.4" "1218.7" "1268.9" "1295.8" "" "" "" "" "" "" "" "" "" "" "1077.2" "975.7" "1188.7" "1176.5" "1006.3" "1319.9" "904.8" "1076.4" "1135.4" "462.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1246779234316334068" "False" "High" "IsMasterProtein" "P49773" "Adenosine 5'-monophosphoramidase HINT1 OS=Homo sapiens OX=9606 GN=HINT1 PE=1 SV=2" "0.000" "False" "45.550" "79" "7" "22" "7" "126" "13.8" "6.95" "88.07" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01230" "3094" "ENSG00000169567" "HINT1" "hsa:3094; P49773; Q9H5W8" "" "" "0" "0" "0.967" "0.903" "1.002" "0.884" "1.022" "0.884" "1.050" "0.922" "0.802" "2324.0" "2246.9" "2099.7" "2329.0" "2055.3" "2374.6" "2054.3" "2440.1" "2143.9" "1863.3" "" "" "" "" "" "" "" "" "" "" "2089.5" "1818.1" "1899.3" "2273.5" "1696.1" "2374.6" "1538.2" "2155.3" "1918.3" "665.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1688448728000248200" "False" "High" "IsMasterProtein" "Q9BZH6" "WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=WDR11 PE=1 SV=1" "0.000" "False" "45.539" "13" "14" "18" "14" "1224" "136.6" "6.92" "60.73" "14" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "55717" "ENSG00000120008" "WDR11" "hsa:55717; Q5VWA1; Q9BZH6; Q9P2J6" "" "RHOH GTPase cycle" "1" "0" "1.130" "1.037" "0.942" "1.157" "1.012" "1.050" "0.984" "1.104" "1.208" "1596.0" "1803.7" "1655.6" "1502.8" "1845.8" "1615.3" "1676.1" "1570.3" "1762.0" "1928.1" "" "" "" "" "" "" "" "" "" "" "1435.0" "1459.5" "1497.5" "1467.0" "1523.2" "1615.3" "1255.0" "1387.0" "1576.6" "688.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7649239600803351534" "False" "High" "IsMasterProtein" "Q96JY6" "PDZ and LIM domain protein 2 OS=Homo sapiens OX=9606 GN=PDLIM2 PE=1 SV=1" "0.000" "False" "45.513" "39" "11" "15" "11" "352" "37.4" "8.72" "58.47" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "64236" "ENSG00000120913" "PDLIM2" "D3DSR5; hsa:64236; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q96JY6; Q9H4L9; Q9H7I2" "" "" "0" "0" "0.991" "1.080" "1.035" "1.077" "1.174" "1.018" "1.009" "1.147" "1.061" "1509.6" "1496.5" "1630.7" "1562.9" "1626.0" "1772.3" "1537.1" "1523.0" "1731.8" "1601.9" "" "" "" "" "" "" "" "" "" "" "1357.3" "1210.9" "1475.0" "1525.6" "1341.8" "1772.3" "1150.9" "1345.2" "1549.6" "571.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100137965290358990" "False" "High" "IsMasterProtein" "Q9UJW0" "Dynactin subunit 4 OS=Homo sapiens OX=9606 GN=DCTN4 PE=1 SV=1" "0.000" "False" "45.498" "28" "10" "17" "10" "460" "52.3" "7.34" "62.81" "10" "" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05502" "51164" "ENSG00000132912" "DCTN4" "B3KWW0; D3DQH0; E5RGT5; hsa:51164; Q8TAN8; Q9UJW0" "Vasopressin-regulated water reabsorption" "HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; MHC class II antigen presentation; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.052" "1.073" "0.965" "1.060" "0.987" "1.017" "1.033" "1.017" "0.888" "999.7" "1051.7" "1073.0" "964.8" "1060.2" "987.1" "1016.8" "1032.4" "1016.2" "887.5" "" "" "" "" "" "" "" "" "" "" "898.8" "851.0" "970.6" "941.7" "874.9" "987.1" "761.3" "911.9" "909.3" "316.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575991461264525713" "False" "High" "IsMasterProtein" "Q99933" "BAG family molecular chaperone regulator 1 OS=Homo sapiens OX=9606 GN=BAG1 PE=1 SV=4" "0.000" "False" "45.494" "36" "10" "15" "10" "345" "38.8" "7.81" "55.37" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf02179" "573" "ENSG00000107262" "BAG1" "hsa:573; O75315; Q14414; Q53H32; Q5VZE8; Q5VZE9; Q5VZF0; Q96TG2; Q99933; Q9Y2V4" "Androgen receptor signaling pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.864" "0.928" "0.951" "0.985" "0.917" "0.961" "0.973" "0.919" "0.835" "1003.7" "866.7" "931.3" "954.0" "988.8" "919.9" "964.2" "976.6" "922.0" "838.3" "" "" "" "" "" "" "" "" "" "" "902.4" "701.3" "842.4" "931.2" "816.0" "919.9" "721.9" "862.6" "825.0" "299.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7781995361222793159" "False" "High" "IsMasterProtein" "Q9UJX2" "Cell division cycle protein 23 homolog OS=Homo sapiens OX=9606 GN=CDC23 PE=1 SV=3" "0.000" "False" "45.480" "22" "12" "16" "12" "597" "68.8" "7.02" "56.96" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04049" "8697" "ENSG00000094880" "CDC23" "A8K6E5; B4E3A2; B7WP05; D3DQB7; hsa:8697; O75433; Q53FN2; Q9BS73; Q9UJX2" "Cell cycle" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.002" "0.952" "0.918" "0.959" "0.952" "0.999" "0.935" "1.024" "0.953" "826.2" "827.9" "786.3" "758.2" "792.7" "786.2" "825.1" "772.4" "846.4" "787.5" "" "" "" "" "" "" "" "" "" "" "742.8" "669.9" "711.2" "740.1" "654.1" "786.2" "617.8" "682.2" "757.4" "281.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "57787487465406304" "False" "High" "IsMasterProtein" "Q08945" "FACT complex subunit SSRP1 OS=Homo sapiens OX=9606 GN=SSRP1 PE=1 SV=1" "0.000" "False" "45.472" "16" "11" "17" "11" "709" "81.0" "6.87" "60.80" "11" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf03531, Pf08512, Pf17292, Pf21092, Pf21103" "6749" "ENSG00000149136" "SSRP1" "hsa:6749; Q08945; Q5BJG8" "" "Regulation of TP53 Activity through Phosphorylation; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "12" "0" "0.970" "0.960" "0.889" "1.018" "0.997" "1.009" "0.888" "0.943" "0.597" "1063.2" "1031.6" "1021.0" "945.5" "1082.8" "1059.7" "1072.4" "944.5" "1002.1" "634.4" "" "" "" "" "" "" "" "" "" "" "955.9" "834.8" "923.6" "923.0" "893.5" "1059.7" "803.0" "834.2" "896.7" "226.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8434101151437963191" "False" "High" "IsMasterProtein" "Q7Z2K8" "G protein-regulated inducer of neurite outgrowth 1 OS=Homo sapiens OX=9606 GN=GPRIN1 PE=1 SV=2" "0.000" "False" "45.446" "17" "18" "21" "18" "1008" "102.3" "8.06" "52.78" "18" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf15235" "114787" "ENSG00000169258" "GPRIN1" "C9JM70; hsa:114787; Q7Z2K8; Q8ND74; Q96PZ4" "MECP2 and associated Rett syndrome; 5q35 copy number variation" "MECP2 regulates neuronal receptors and channels" "3" "0" "0.940" "1.037" "0.951" "0.953" "1.107" "0.968" "0.952" "1.091" "0.856" "715.6" "672.9" "741.8" "680.3" "682.1" "792.4" "692.9" "681.1" "781.0" "612.3" "" "" "" "" "" "" "" "" "" "" "643.4" "544.5" "671.0" "664.1" "562.9" "792.4" "518.8" "601.6" "698.9" "218.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047661720353379507" "False" "High" "IsMasterProtein" "Q03426" "Mevalonate kinase OS=Homo sapiens OX=9606 GN=MVK PE=1 SV=1" "0.000" "False" "45.405" "30" "10" "15" "10" "396" "42.4" "6.46" "56.26" "10" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00288, Pf08544" "4598" "ENSG00000110921" "MVK" "hsa:4598; Q03426" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.047" "1.178" "1.019" "1.120" "1.121" "1.071" "1.106" "1.174" "0.914" "1139.4" "1193.2" "1342.3" "1161.2" "1275.7" "1277.7" "1220.6" "1259.7" "1337.9" "1041.8" "" "" "" "" "" "" "" "" "" "" "1024.4" "965.5" "1214.2" "1133.5" "1052.7" "1277.7" "914.0" "1112.6" "1197.1" "371.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4135876604710417259" "False" "High" "IsMasterProtein" "P49593" "Protein phosphatase 1F OS=Homo sapiens OX=9606 GN=PPM1F PE=1 SV=3" "0.000" "False" "45.378" "28" "10" "15" "10" "454" "49.8" "5.10" "52.67" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00481" "9647" "ENSG00000100034" "PPM1F" "A8K6G3; B7Z2C3; hsa:9647; P49593; Q96PM2" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "1.048" "1.067" "0.949" "1.097" "1.013" "0.999" "1.003" "0.998" "1.061" "840.0" "880.2" "896.1" "796.9" "921.5" "851.2" "839.4" "842.2" "838.6" "890.9" "" "" "" "" "" "" "" "" "" "" "755.2" "712.2" "810.6" "777.8" "760.4" "851.2" "628.5" "743.9" "750.4" "318.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2160825122742080574" "False" "High" "IsMasterProtein" "Q13162" "Peroxiredoxin-4 OS=Homo sapiens OX=9606 GN=PRDX4 PE=1 SV=1" "0.000" "False" "45.359" "35" "10" "35" "7" "271" "30.5" "6.29" "117.92" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00578, Pf10417" "10549" "ENSG00000123131" "PRDX4" "hsa:10549; Q13162; Q6FHT3" "Selenium micronutrient network" "Neutrophil degranulation" "2" "0" "1.013" "1.041" "1.071" "1.086" "1.006" "1.054" "0.991" "1.138" "0.841" "1137.6" "1152.0" "1183.9" "1218.8" "1235.4" "1144.8" "1199.6" "1127.6" "1294.1" "956.7" "" "" "" "" "" "" "" "" "" "" "1022.8" "932.2" "1070.9" "1189.7" "1019.5" "1144.8" "898.2" "996.0" "1158.0" "341.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1234088544826657040" "False" "High" "IsMasterProtein" "Q9H871" "E3 ubiquitin-protein transferase RMND5A OS=Homo sapiens OX=9606 GN=RMND5A PE=1 SV=1" "0.000" "False" "45.334" "34" "10" "15" "10" "391" "44.0" "6.06" "54.51" "10" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10607, Pf13445" "64795" "ENSG00000153561" "RMND5A" "D6W5M6; hsa:64795; Q6NTF0; Q9H6W5; Q9H871; Q9H9H2" "Ciliary landscape" "" "1" "0" "1.010" "1.049" "1.004" "1.044" "0.983" "0.959" "1.037" "1.068" "0.993" "649.7" "656.2" "681.4" "652.1" "678.1" "638.9" "623.3" "673.5" "693.6" "645.4" "" "" "" "" "" "" "" "" "" "" "584.2" "531.0" "616.3" "636.6" "559.6" "638.9" "466.7" "594.9" "620.6" "230.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5820221568948669859" "False" "High" "IsMasterProtein" "P61081" "NEDD8-conjugating enzyme Ubc12 OS=Homo sapiens OX=9606 GN=UBE2M PE=1 SV=1" "0.000" "False" "45.333" "47" "9" "23" "9" "183" "20.9" "7.69" "84.09" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "9040" "ENSG00000130725" "UBE2M" "hsa:9040; O76069; P61081; Q8VC50" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; TGF-beta receptor signaling activates SMADs" "5" "0" "1.118" "1.112" "1.103" "1.132" "1.064" "1.025" "1.146" "1.154" "0.938" "2310.5" "2583.1" "2569.1" "2547.9" "2616.2" "2459.2" "2368.0" "2648.2" "2667.1" "2167.2" "" "" "" "" "" "" "" "" "" "" "2077.3" "2090.1" "2323.8" "2487.1" "2159.0" "2459.2" "1773.1" "2339.0" "2386.5" "773.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858291838725637521" "False" "High" "IsMasterProtein" "Q14353" "Guanidinoacetate N-methyltransferase OS=Homo sapiens OX=9606 GN=GAMT PE=1 SV=1" "0.000" "False" "45.331" "37" "6" "15" "6" "236" "26.3" "6.14" "57.26" "6" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "" "2593" "ENSG00000130005" "GAMT" "A8K0A0; hsa:2593; Q14353; Q53Y34; Q8WVJ1" "MECP2 and associated Rett syndrome; Creatine pathway" "Transcriptional Regulation by MECP2; Creatine metabolism" "4" "0" "1.035" "0.998" "1.078" "1.044" "1.052" "1.014" "1.034" "1.032" "0.852" "653.7" "676.7" "652.1" "704.7" "682.4" "688.0" "662.9" "676.0" "674.5" "556.9" "" "" "" "" "" "" "" "" "" "" "587.7" "547.6" "589.8" "687.9" "563.2" "688.0" "496.3" "597.1" "603.5" "198.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5966605329502245695" "False" "High" "IsMasterProtein" "P10599" "Thioredoxin OS=Homo sapiens OX=9606 GN=TXN PE=1 SV=3" "0.000" "False" "45.328" "77" "8" "47" "8" "105" "11.7" "4.92" "173.88" "8" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00085" "7295" "ENSG00000136810" "TXN" "B1ALW1; hsa:7295; O60744; P10599; Q53X69; Q96KI3; Q9UDG5" "Selenium micronutrient network; Folic acid network; Selenium micronutrient network ; Folic acid network; Selenium micronutrient network; TNF-alpha signaling pathway; Complement system; Nuclear receptors meta-pathway; NRF2 pathway; VEGFA-VEGFR2 signaling; TAR syndrome" "TP53 Regulates Metabolic Genes; Detoxification of Reactive Oxygen Species; Oxidative Stress Induced Senescence; Interconversion of nucleotide di- and triphosphates; NFE2L2 regulating anti-oxidant/detoxification enzymes; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Regulation of FOXO transcriptional activity by acetylation; Protein repair" "20" "0" "0.948" "0.902" "0.886" "0.890" "0.929" "0.902" "0.975" "0.837" "0.700" "5300.8" "5026.8" "4779.4" "4698.6" "4717.6" "4926.5" "4780.5" "5170.2" "4435.9" "3709.6" "" "" "" "" "" "" "" "" "" "" "4765.9" "4067.5" "4323.1" "4586.4" "3893.1" "4926.5" "3579.5" "4566.7" "3969.2" "1324.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486166187731566186" "False" "High" "IsMasterProtein" "Q9BV57" "Acireductone dioxygenase OS=Homo sapiens OX=9606 GN=ADI1 PE=1 SV=1" "0.000" "False" "45.275" "70" "10" "19" "10" "179" "21.5" "5.68" "67.59" "10" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03079" "55256" "ENSG00000182551" "ADI1" "D6W4Y3; hsa:55256; Q53HW3; Q53QD3; Q57YV7; Q68CK2; Q6ZSF7; Q7Z512; Q96P85; Q9BV57; Q9NV57" "Methionine de novo and salvage pathway" "Methionine salvage pathway" "2" "0" "0.899" "0.916" "0.976" "0.888" "0.887" "0.935" "0.914" "0.847" "1.171" "1726.7" "1551.9" "1581.6" "1685.4" "1533.8" "1531.7" "1614.5" "1578.9" "1462.3" "2021.6" "" "" "" "" "" "" "" "" "" "" "1552.4" "1255.8" "1430.6" "1645.2" "1265.7" "1531.7" "1208.9" "1394.6" "1308.5" "721.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-377515032386624778" "False" "High" "IsMasterProtein" "P78346" "Ribonuclease P protein subunit p30 OS=Homo sapiens OX=9606 GN=RPP30 PE=1 SV=1" "0.000" "False" "45.266" "42" "9" "16" "9" "268" "29.3" "8.91" "57.61" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01876" "10556" "ENSG00000148688" "RPP30" "B2R799; E9PB02; hsa:10556; P78346" "" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "2" "0" "1.028" "1.023" "1.001" "1.069" "1.042" "1.072" "0.997" "1.066" "1.015" "948.0" "974.7" "970.2" "949.2" "1013.8" "988.2" "1016.6" "945.5" "1010.2" "961.9" "" "" "" "" "" "" "" "" "" "" "852.3" "788.7" "877.6" "926.5" "836.6" "988.2" "761.2" "835.1" "903.9" "343.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "568464796837822948" "False" "High" "IsMasterProtein" "O43823" "A-kinase anchor protein 8 OS=Homo sapiens OX=9606 GN=AKAP8 PE=1 SV=1" "0.000" "False" "45.244" "18" "11" "14" "11" "692" "76.1" "5.15" "58.77" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "10270" "ENSG00000105127" "AKAP8" "hsa:10270; O43823" "G protein signaling pathways" "" "1" "0" "0.917" "0.891" "0.922" "0.975" "0.931" "1.017" "0.930" "0.881" "1.359" "532.2" "488.3" "474.2" "490.9" "518.9" "495.6" "541.3" "494.7" "468.9" "723.5" "" "" "" "" "" "" "" "" "" "" "478.5" "395.1" "428.9" "479.2" "428.2" "495.6" "405.3" "436.9" "419.6" "258.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6123043622142940735" "False" "High" "IsMasterProtein" "P55145" "Mesencephalic astrocyte-derived neurotrophic factor OS=Homo sapiens OX=9606 GN=MANF PE=1 SV=3" "0.000" "False" "45.150" "36" "7" "15" "7" "182" "20.7" "8.69" "62.74" "7" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10208, Pf20145" "7873" "ENSG00000145050" "MANF" "hsa:7873; P55145; Q14CX4; Q86U67; Q96IS4" "Orexin receptor pathway" "Platelet degranulation" "2" "0" "0.835" "0.976" "0.926" "1.006" "1.011" "0.951" "1.008" "1.050" "0.761" "2164.1" "1806.4" "2111.7" "2004.4" "2177.5" "2187.3" "2058.4" "2181.8" "2271.3" "1645.9" "" "" "" "" "" "" "" "" "" "" "1945.8" "1461.7" "1910.1" "1956.6" "1796.9" "2187.3" "1541.3" "1927.1" "2032.3" "587.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4947084340596136770" "False" "High" "IsMasterProtein" "Q8TF05" "Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens OX=9606 GN=PPP4R1 PE=1 SV=1" "0.000" "False" "45.133" "16" "13" "17" "13" "950" "106.9" "4.77" "46.67" "13" "protein metabolism;other metabolic processes;signal transduction" "other cell component" "enzyme regulator activity" "Pf02985, Pf15017" "9989" "ENSG00000154845" "PPP4R1" "hsa:9989; Q8TF05; Q99774; Q9UNQ7" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.037" "1.078" "1.009" "1.078" "1.045" "1.062" "1.047" "1.075" "1.048" "1183.5" "1227.2" "1275.8" "1193.8" "1275.5" "1236.5" "1257.3" "1239.1" "1272.7" "1240.3" "" "" "" "" "" "" "" "" "" "" "1064.0" "993.0" "1154.0" "1165.3" "1052.6" "1236.5" "941.5" "1094.5" "1138.8" "442.8" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3193827358447086587" "False" "High" "IsMasterProtein" "P20936" "Ras GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=RASA1 PE=1 SV=1" "0.000" "False" "45.132" "13" "13" "15" "13" "1047" "116.3" "6.54" "52.25" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00168, Pf00169, Pf00616" "5921" "ENSG00000145715" "RASA1" "B2R6W3; B4DTL2; hsa:5921; P20936; Q68CU6; Q9UDI1" "Androgen receptor network in prostate cancer; PDGF pathway; T cell receptor and co-stimulatory signaling; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; PDGFR-beta pathway; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; GDNF signaling; EPO receptor signaling" "Regulation of RAS by GAPs; EPHB-mediated forward signaling; Downstream signal transduction; VEGFR2 mediated cell proliferation; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "17" "0" "1.102" "0.983" "0.971" "1.129" "0.980" "1.079" "0.988" "0.996" "1.126" "835.8" "921.1" "821.7" "811.6" "943.7" "819.1" "901.7" "826.1" "832.8" "941.5" "" "" "" "" "" "" "" "" "" "" "751.5" "745.3" "743.3" "792.2" "778.7" "819.1" "675.2" "729.7" "745.2" "336.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6155932716542002822" "False" "High" "IsMasterProtein" "P06239" "Tyrosine-protein kinase Lck OS=Homo sapiens OX=9606 GN=LCK PE=1 SV=6" "0.000" "False" "45.120" "23" "10" "16" "8" "509" "58.0" "5.36" "61.61" "10" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "3932" "ENSG00000182866" "LCK" "D3DPP8; hsa:3932; P06239; P07100; Q12850; Q13152; Q5TDH8; Q5TDH9; Q7RTZ3; Q96DW4; Q9NYT8" "Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Inflammatory response pathway; Cancer immunotherapy by PD-1 blockade; IL-18 signaling pathway; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; IL-2 signaling pathway; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; Th17 cell differentiation pathway; Calcium mediated T-cell apoptosis involved in inclusion body myositis; TAR syndrome; Interferon type I signaling pathways; Notch signaling pathway; T-cell receptor signaling pathway" "RHOH GTPase cycle; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; GPVI-mediated activation cascade; DAP12 signaling; CD28 dependent PI3K/Akt signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Regulation of KIT signaling; CD28 dependent Vav1 pathway; Nef Mediated CD4 Down-regulation; Interleukin-2 signaling; Nef and signal transduction; PECAM1 interactions; CTLA4 inhibitory signaling; FLT3 signaling through SRC family kinases" "40" "1" "1.099" "1.038" "1.010" "1.095" "1.123" "1.170" "1.031" "1.103" "1.299" "741.2" "814.8" "769.5" "748.6" "811.5" "832.4" "866.8" "764.1" "817.5" "962.7" "" "" "" "" "" "" "" "" "" "" "666.4" "659.3" "696.1" "730.7" "669.6" "832.4" "649.1" "674.9" "731.5" "343.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7527974897574347786" "False" "High" "IsMasterProtein" "Q16778" "Histone H2B type 2-E OS=Homo sapiens OX=9606 GN=H2BC21 PE=1 SV=3" "0.000" "False" "45.106" "41" "6" "33" "2" "126" "13.9" "10.32" "119.54" "6" "cell organization and biogenesis;stress response" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "8349" "ENSG00000184678" "H2BC21" "A3KMC7; A8K110; hsa:8349; Q16778; Q4KMY1; Q5QNX0; Q9UE88" "" "Ub-specific processing proteases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; HCMV Late Events; HCMV Early Events; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Nonhomologous End-Joining (NHEJ); Assembly of the ORC complex at the origin of replication; HATs acetylate histones; Amyloid fiber formation; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "44" "6" "0.887" "0.851" "0.927" "0.999" "0.973" "0.904" "0.944" "0.834" "0.924" "1777.0" "1576.6" "1512.8" "1647.8" "1774.5" "1729.9" "1607.2" "1678.1" "1482.8" "1641.6" "" "" "" "" "" "" "" "" "" "" "1597.7" "1275.7" "1368.4" "1608.5" "1464.4" "1729.9" "1203.4" "1482.2" "1326.8" "586.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5760294074974619673" "False" "High" "IsMasterProtein" "O95319" "CUGBP Elav-like family member 2 OS=Homo sapiens OX=9606 GN=CELF2 PE=1 SV=1" "0.000" "False" "45.089" "21" "10" "21" "8" "508" "54.3" "8.76" "69.35" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10659" "ENSG00000048740" "CELF2" "B7ZAN9; O95319; Q7KYU4; Q8N499; Q92950; Q96NW9; Q96RQ5; Q96RQ6; Q9UL67" "mRNA processing; Opioid receptor pathways" "" "2" "2" "1.064" "1.011" "1.139" "1.012" "1.195" "1.023" "1.095" "1.068" "1.144" "1282.3" "1364.5" "1296.5" "1460.1" "1298.1" "1532.5" "1312.0" "1404.5" "1368.9" "1467.5" "" "" "" "" "" "" "" "" "" "" "1152.9" "1104.1" "1172.8" "1425.2" "1071.2" "1532.5" "982.4" "1240.5" "1224.9" "523.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4473457085686512926" "False" "High" "IsMasterProtein" "Q16186" "Proteasomal ubiquitin receptor ADRM1 OS=Homo sapiens OX=9606 GN=ADRM1 PE=1 SV=2" "0.000" "False" "45.084" "24" "10" "23" "10" "407" "42.1" "5.07" "73.39" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04683, Pf16550" "11047" "ENSG00000130706" "ADRM1" "A0PKB1; hsa:11047; Q16186; Q96FJ7; Q9H1P2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Ub-specific processing proteases; UCH proteinases" "4" "0" "1.038" "1.016" "1.034" "0.961" "1.069" "1.095" "1.005" "0.983" "1.085" "1667.0" "1730.3" "1693.8" "1722.9" "1602.1" "1781.4" "1824.6" "1674.6" "1638.6" "1808.5" "" "" "" "" "" "" "" "" "" "" "1498.8" "1400.1" "1532.1" "1681.8" "1322.0" "1781.4" "1366.2" "1479.2" "1466.2" "645.6" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "598569642609282214" "False" "High" "IsMasterProtein" "Q9BRS2" "Serine/threonine-protein kinase RIO1 OS=Homo sapiens OX=9606 GN=RIOK1 PE=1 SV=2" "0.000" "False" "45.008" "28" "14" "15" "14" "568" "65.5" "6.19" "49.55" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01163" "83732" "ENSG00000124784" "RIOK1" "B2RB28; Q8NDC8; Q96NV9; Q9BRS2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.050" "1.010" "0.990" "1.045" "1.013" "1.030" "1.022" "1.067" "0.899" "851.3" "894.0" "859.6" "843.0" "889.7" "862.1" "877.1" "870.5" "908.0" "765.1" "" "" "" "" "" "" "" "" "" "" "765.4" "723.4" "777.5" "822.9" "734.2" "862.1" "656.7" "768.8" "812.4" "273.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6538585977691412019" "False" "High" "IsMasterProtein" "Q9BYB4" "Guanine nucleotide-binding protein subunit beta-like protein 1 OS=Homo sapiens OX=9606 GN=GNB1L PE=1 SV=2" "0.000" "False" "45.005" "34" "9" "13" "9" "327" "35.6" "7.97" "51.81" "9" "" "" "" "Pf00400" "54584" "ENSG00000185838" "GNB1L" "hsa:54584; Q9BYB4; Q9H2S2; Q9H4M4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.001" "0.912" "0.956" "1.076" "0.923" "1.051" "1.000" "0.932" "0.928" "872.8" "873.6" "796.4" "834.4" "939.2" "805.5" "917.3" "872.7" "813.3" "809.5" "" "" "" "" "" "" "" "" "" "" "784.7" "706.9" "720.3" "814.5" "775.0" "805.5" "686.9" "770.8" "727.8" "289.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8207864549745438201" "False" "High" "IsMasterProtein" "Q96T76" "MMS19 nucleotide excision repair protein homolog OS=Homo sapiens OX=9606 GN=MMS19 PE=1 SV=2" "0.000" "False" "44.985" "16" "14" "19" "14" "1030" "113.2" "6.35" "55.91" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf12460, Pf14500" "64210" "ENSG00000155229" "MMS19" "B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2; hsa:64210; Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; Q96DF1; Q96MR1; Q96RK5; Q96SK1; Q96T76; Q9BUE2; Q9BYS9" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.080" "1.077" "1.030" "1.113" "1.056" "1.097" "1.072" "1.116" "1.210" "665.7" "719.3" "717.2" "685.9" "740.7" "703.2" "730.1" "713.8" "742.9" "805.2" "" "" "" "" "" "" "" "" "" "" "598.6" "582.0" "648.7" "669.5" "611.2" "703.2" "546.7" "630.5" "664.7" "287.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625862126903742140" "False" "High" "IsMasterProtein" "P48556" "26S proteasome non-ATPase regulatory subunit 8 OS=Homo sapiens OX=9606 GN=PSMD8 PE=1 SV=2" "0.000" "False" "44.984" "29" "11" "19" "11" "350" "39.6" "9.70" "69.01" "11" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf10075" "5714" "ENSG00000099341" "PSMD8" "B4DX18; hsa:5714; P48556; Q6P1L7" "Proteasome degradation; Alzheimer's disease and miRNA effects; Parkin-ubiquitin proteasomal system pathway; Ciliary landscape; Alzheimer's disease" "Regulation of PTEN stability and activity; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "64" "0" "0.993" "1.018" "1.000" "1.064" "0.983" "1.001" "0.963" "1.021" "0.803" "2228.9" "2213.1" "2268.1" "2230.0" "2371.4" "2190.9" "2232.0" "2145.4" "2276.8" "1789.3" "" "" "" "" "" "" "" "" "" "" "2004.0" "1790.8" "2051.6" "2176.7" "1956.9" "2190.9" "1671.3" "1895.0" "2037.3" "638.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2093622572460603588" "False" "High" "IsMasterProtein" "Q8NBF6" "Late secretory pathway protein AVL9 homolog OS=Homo sapiens OX=9606 GN=AVL9 PE=1 SV=1" "0.000" "False" "44.958" "19" "11" "17" "11" "648" "71.9" "6.21" "51.25" "11" "other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf09794" "23080" "ENSG00000105778" "AVL9" "hsa:23080; Q8NBF6; Q92573" "" "" "0" "0" "1.041" "0.966" "1.007" "1.041" "0.930" "1.000" "0.961" "0.960" "0.881" "758.8" "789.9" "732.6" "763.7" "789.7" "705.8" "758.9" "728.9" "728.4" "668.8" "" "" "" "" "" "" "" "" "" "" "682.2" "639.2" "662.7" "745.5" "651.7" "705.8" "568.3" "643.8" "651.7" "238.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-792306396308701389" "False" "High" "IsMasterProtein" "Q9Y2W1" "Thyroid hormone receptor-associated protein 3 OS=Homo sapiens OX=9606 GN=THRAP3 PE=1 SV=2" "0.000" "False" "44.951" "14" "14" "15" "13" "955" "108.6" "10.15" "51.99" "14" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf15440" "9967" "ENSG00000054118" "THRAP3" "D3DPS5; hsa:9967; Q5VTK6; Q9Y2W1" "Interactome of polycomb repressive complex 2 (PRC2)" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "3" "1" "1.011" "1.081" "1.031" "1.073" "1.154" "1.106" "0.963" "0.967" "0.950" "1451.9" "1467.7" "1569.8" "1497.5" "1557.6" "1676.0" "1605.3" "1398.6" "1404.0" "1379.9" "" "" "" "" "" "" "" "" "" "" "1305.4" "1187.6" "1419.9" "1461.8" "1285.3" "1676.0" "1202.0" "1235.3" "1256.3" "492.6" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1594484432885072185" "False" "High" "IsMasterProtein" "O75663" "TIP41-like protein OS=Homo sapiens OX=9606 GN=TIPRL PE=1 SV=2" "0.000" "False" "44.947" "41" "9" "18" "9" "272" "31.4" "5.91" "60.43" "9" "stress response;signal transduction;other biological processes" "cytosol" "" "Pf04176" "261726" "ENSG00000143155" "TIPRL" "B2R8V3; hsa:261726; O75663; Q5HYB2; Q8IZ86" "Ciliary landscape" "" "1" "0" "1.001" "0.992" "1.022" "0.962" "0.973" "0.986" "0.962" "0.922" "1.134" "1747.8" "1749.4" "1734.6" "1786.2" "1681.4" "1699.9" "1724.2" "1682.1" "1611.8" "1982.7" "" "" "" "" "" "" "" "" "" "" "1571.5" "1415.5" "1569.0" "1743.5" "1387.5" "1699.9" "1291.0" "1485.7" "1442.2" "707.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846658872779087383" "False" "High" "IsMasterProtein" "P61964" "WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=WDR5 PE=1 SV=1" "0.000" "False" "44.940" "29" "8" "16" "8" "334" "36.6" "8.27" "63.23" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "11091" "ENSG00000196363" "WDR5" "hsa:11091; P61964; Q91VA5; Q9NWX7; Q9UGP9" "Pleural mesothelioma; Kleefstra syndrome" "Neddylation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RMTs methylate histone arginines; Formation of WDR5-containing histone-modifying complexes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; HATs acetylate histones; Cardiogenesis" "10" "0" "1.014" "1.080" "1.023" "1.106" "1.066" "1.064" "0.982" "1.079" "1.047" "1973.0" "2001.0" "2131.3" "2018.8" "2183.0" "2103.6" "2099.0" "1936.7" "2128.4" "2064.7" "" "" "" "" "" "" "" "" "" "" "1773.9" "1619.1" "1927.9" "1970.6" "1801.4" "2103.6" "1571.7" "1710.6" "1904.5" "737.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5929165091375925329" "False" "High" "IsMasterProtein" "Q15545" "Transcription initiation factor TFIID subunit 7 OS=Homo sapiens OX=9606 GN=TAF7 PE=1 SV=1" "0.000" "False" "44.932" "32" "11" "14" "11" "349" "40.2" "5.20" "49.72" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04658" "6879" "ENSG00000178913" "TAF7" "B2RBV9; hsa:6879; Q13036; Q15545" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "0.975" "0.949" "0.970" "1.064" "1.028" "1.047" "1.004" "1.051" "1.053" "1123.7" "1096.0" "1066.9" "1089.8" "1195.4" "1154.8" "1177.0" "1128.6" "1180.9" "1183.5" "" "" "" "" "" "" "" "" "" "" "1010.3" "886.9" "965.1" "1063.8" "986.5" "1154.8" "881.3" "996.8" "1056.6" "422.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7099090004337322375" "False" "High" "IsMasterProtein" "P63167" "Dynein light chain 1, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL1 PE=1 SV=1" "0.000" "False" "44.905" "58" "5" "22" "2" "89" "10.4" "7.40" "103.62" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01221" "8655" "ENSG00000088986" "DYNLL1" "hsa:8655; P63167; Q15701" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Neutrophil degranulation; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Aggrephagy; Intraflagellar transport; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; Recruitment of NuMA to mitotic centrosomes; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Macroautophagy; Activation of BIM and translocation to mitochondria" "28" "2" "0.971" "0.974" "0.980" "1.003" "1.019" "0.989" "1.003" "1.071" "1.044" "1992.1" "1934.2" "1940.8" "1952.0" "1998.3" "2029.9" "1969.5" "1998.7" "2133.7" "2080.5" "" "" "" "" "" "" "" "" "" "" "1791.1" "1565.1" "1755.5" "1905.4" "1649.0" "2029.9" "1474.7" "1765.4" "1909.2" "742.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5062141414675458558" "False" "High" "IsMasterProtein" "Q9P0L0" "Vesicle-associated membrane protein-associated protein A OS=Homo sapiens OX=9606 GN=VAPA PE=1 SV=3" "0.000" "False" "44.883" "34" "7" "17" "6" "249" "27.9" "8.62" "60.14" "7" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9218" "ENSG00000101558" "VAPA" "A6NDZ0; D3DUI3; hsa:9218; O75453; Q5U0E7; Q9P0L0; Q9UBZ2" "Exercise-induced circadian regulation; Cholesterol metabolism" "Neutrophil degranulation; Sphingolipid de novo biosynthesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "5" "1" "0.895" "0.942" "1.026" "0.998" "0.932" "1.044" "0.953" "0.874" "0.638" "3269.7" "2926.3" "3080.0" "3356.0" "3263.3" "3045.8" "3412.0" "3115.3" "2859.0" "2086.2" "" "" "" "" "" "" "" "" "" "" "2939.8" "2367.9" "2786.0" "3276.0" "2693.0" "3045.8" "2554.8" "2751.6" "2558.2" "744.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6656538987652310722" "False" "High" "IsMasterProtein" "Q86X29" "Lipolysis-stimulated lipoprotein receptor OS=Homo sapiens OX=9606 GN=LSR PE=1 SV=4" "0.000" "False" "44.882" "20" "11" "15" "11" "649" "71.4" "7.97" "58.37" "11" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf05624" "51599" "ENSG00000105699" "LSR" "A6NDW3; B4DKL4; E9PHD4; hsa:51599; O00112; O00426; Q6ZT80; Q86X29; Q8NBM0; Q9BT33; Q9UQL3" "" "LDL clearance; VLDL clearance" "2" "0" "0.968" "1.055" "0.996" "0.923" "1.091" "0.991" "1.001" "0.993" "0.761" "862.2" "834.9" "909.8" "859.0" "795.7" "940.9" "854.5" "863.1" "856.1" "655.8" "" "" "" "" "" "" "" "" "" "" "775.2" "675.6" "822.9" "838.5" "656.6" "940.9" "639.8" "762.4" "766.0" "234.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588161142439279914" "False" "High" "IsMasterProtein" "Q96RG2" "PAS domain-containing serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=PASK PE=1 SV=3" "0.000" "False" "44.881" "12" "12" "14" "12" "1323" "142.8" "4.86" "47.19" "12" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13426" "23178" "ENSG00000115687" "PASK" "G5E9F1; hsa:23178; Q05BE4; Q68DY3; Q6GSJ5; Q86XH6; Q96RG2; Q99763; Q9UFR7" "2q37 copy number variation syndrome" "" "1" "0" "1.076" "1.130" "0.972" "1.110" "1.120" "1.173" "1.028" "1.185" "0.932" "608.0" "654.2" "687.1" "590.9" "674.8" "680.9" "713.4" "624.8" "720.5" "566.6" "" "" "" "" "" "" "" "" "" "" "546.6" "529.4" "621.5" "576.8" "556.9" "680.9" "534.2" "551.9" "644.7" "202.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982176321518383" "False" "High" "IsMasterProtein" "Q92572" "AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1" "0.000" "False" "44.862" "51" "8" "17" "8" "193" "21.7" "5.39" "64.52" "8" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01217" "1176" "ENSG00000177879" "AP3S1" "hsa:1176; O00647; O00676; O00721; O00727; Q53XL4; Q6ICQ2; Q92572" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "0.974" "0.983" "0.925" "0.997" "0.923" "0.965" "0.948" "0.930" "1.036" "1420.5" "1383.8" "1396.7" "1314.0" "1416.6" "1311.5" "1371.2" "1346.3" "1321.1" "1471.7" "" "" "" "" "" "" "" "" "" "" "1277.2" "1119.7" "1263.4" "1282.6" "1169.0" "1311.5" "1026.7" "1189.2" "1182.1" "525.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819373703684901703" "False" "High" "IsMasterProtein" "Q2KHT3" "Protein CLEC16A OS=Homo sapiens OX=9606 GN=CLEC16A PE=1 SV=2" "0.000" "False" "44.845" "12" "12" "15" "12" "1053" "117.6" "5.86" "53.77" "12" "other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf09758, Pf19439" "23274" "ENSG00000038532" "CLEC16A" "hsa:23274; O15058; Q2KHT3; Q6ZTB2" "Vitamin D receptor pathway" "" "1" "0" "1.028" "1.032" "0.992" "1.065" "0.986" "1.054" "1.037" "1.041" "0.840" "1238.5" "1273.3" "1278.3" "1228.5" "1319.5" "1221.0" "1305.1" "1284.2" "1289.1" "1041.0" "" "" "" "" "" "" "" "" "" "" "1113.6" "1030.3" "1156.3" "1199.2" "1088.9" "1221.0" "977.3" "1134.3" "1153.5" "371.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1383299506835269053" "False" "High" "IsMasterProtein" "Q9HCJ6" "Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens OX=9606 GN=VAT1L PE=1 SV=2" "0.000" "False" "44.827" "33" "12" "19" "12" "419" "45.9" "5.06" "56.37" "12" "" "" "other molecular function" "Pf08240, Pf13602" "57687" "ENSG00000171724" "VAT1L" "hsa:57687; Q8IYW8; Q9HCJ6" "" "" "0" "0" "1.015" "0.983" "0.980" "1.050" "0.951" "0.967" "0.952" "1.006" "0.757" "1189.4" "1207.2" "1169.2" "1165.3" "1248.9" "1130.6" "1150.7" "1132.9" "1196.1" "900.0" "" "" "" "" "" "" "" "" "" "" "1069.4" "976.8" "1057.6" "1137.5" "1030.6" "1130.6" "861.6" "1000.6" "1070.3" "321.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8289862670679680301" "False" "High" "IsMasterProtein" "Q96EK7" "Constitutive coactivator of peroxisome proliferator-activated receptor gamma OS=Homo sapiens OX=9606 GN=FAM120B PE=1 SV=1" "0.000" "False" "44.781" "22" "14" "14" "14" "910" "103.7" "5.69" "43.80" "14" "signal transduction;other biological processes" "nucleus" "" "" "84498" "ENSG00000112584; ENSG00000275333" "FAM120B" "B4DL34; hsa:84498; Q86V68; Q96EK7; Q96JI9" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation" "2" "0" "0.972" "1.018" "0.949" "1.042" "1.106" "0.942" "1.010" "1.046" "1.279" "667.8" "649.3" "679.8" "633.6" "696.1" "738.6" "629.3" "674.4" "698.7" "854.3" "" "" "" "" "" "" "" "" "" "" "600.5" "525.4" "614.9" "618.5" "574.4" "738.6" "471.2" "595.7" "625.2" "305.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6469801124856573436" "False" "High" "IsMasterProtein" "P36404" "ADP-ribosylation factor-like protein 2 OS=Homo sapiens OX=9606 GN=ARL2 PE=1 SV=4" "0.000" "False" "44.741" "38" "6" "13" "6" "184" "20.9" "6.34" "55.02" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00025" "402" "ENSG00000213465" "ARL2" "G3V184; hsa:402; P36404; Q9BUK8" "Joubert syndrome" "Post-chaperonin tubulin folding pathway; Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; RAS processing" "4" "0" "1.033" "1.041" "1.003" "1.105" "1.047" "1.023" "0.970" "1.022" "0.788" "1470.5" "1519.5" "1531.3" "1475.2" "1625.1" "1539.1" "1504.5" "1426.1" "1503.4" "1158.2" "" "" "" "" "" "" "" "" "" "" "1322.2" "1229.5" "1385.1" "1440.0" "1341.1" "1539.1" "1126.5" "1259.6" "1345.2" "413.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6367954742648610470" "False" "High" "IsMasterProtein" "Cont_E1BJK2" "Tubulin beta chain OS=Bos taurus OX=9913 GN=TUBB1 PE=3 SV=1" "0.000" "True" "44.729" "10" "7" "62" "1" "450" "50.0" "5.11" "177.15" "7" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "541271" "ENSBIXG00000020524; ENSBTAG00000018785" "TUBB1" "A0A4W2CSS1; bta:541271; E1BJK2" "Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway" "" "2" "0" "1.211" "0.939" "0.776" "1.039" "0.897" "0.607" "0.690" "0.710" "0.269" "23.5" "28.5" "22.1" "18.3" "24.5" "21.1" "14.3" "16.3" "16.7" "6.3" "" "" "" "" "" "" "" "" "" "" "21.2" "23.1" "20.0" "17.8" "20.2" "21.1" "10.7" "14.4" "15.0" "2.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5104969040472016970" "False" "High" "IsMasterProtein" "Q13576" "Ras GTPase-activating-like protein IQGAP2 OS=Homo sapiens OX=9606 GN=IQGAP2 PE=1 SV=4" "0.000" "False" "44.701" "8" "10" "16" "8" "1575" "180.5" "5.64" "51.85" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00307, Pf00612, Pf00616, Pf03836" "10788" "ENSG00000145703" "IQGAP2" "A8K4V1; B7Z8A4; hsa:10788; J3KR91; Q13576" "Ciliary landscape; G13 signaling pathway" "Neutrophil degranulation; RHO GTPases activate IQGAPs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle" "7" "0" "1.012" "0.936" "0.916" "0.942" "0.988" "0.931" "0.908" "0.964" "1.173" "412.8" "417.9" "386.3" "378.3" "389.0" "408.0" "384.4" "375.0" "397.9" "484.4" "" "" "" "" "" "" "" "" "" "" "371.2" "338.1" "349.4" "369.2" "321.0" "408.0" "287.8" "331.3" "356.1" "172.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8721939623497573862" "False" "High" "IsMasterProtein" "Q86YV5" "Inactive tyrosine-protein kinase PRAG1 OS=Homo sapiens OX=9606 GN=PRAG1 PE=1 SV=4" "0.000" "False" "44.690" "12" "12" "14" "12" "1406" "149.5" "7.20" "54.48" "12" "other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf07714" "157285" "ENSG00000275342" "PRAG1" "Q86YV5; Q8N3N5" "" "RND2 GTPase cycle" "1" "0" "0.972" "1.019" "1.033" "0.933" "1.001" "0.988" "0.928" "0.946" "1.303" "545.0" "529.8" "555.2" "563.2" "508.3" "545.7" "538.6" "505.9" "515.3" "710.0" "" "" "" "" "" "" "" "" "" "" "490.0" "428.7" "502.2" "549.8" "419.5" "545.7" "403.3" "446.8" "461.1" "253.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7857445100061984594" "False" "High" "IsMasterProtein" "Q8WVY7" "Ubiquitin-like domain-containing CTD phosphatase 1 OS=Homo sapiens OX=9606 GN=UBLCP1 PE=1 SV=2" "0.000" "False" "44.643" "36" "12" "20" "12" "318" "36.8" "6.46" "66.13" "12" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00240, Pf03031" "134510" "ENSG00000164332" "UBLCP1" "D3DQJ7; hsa:134510; Q8WVY7; Q96DK5" "" "" "0" "0" "1.018" "1.046" "0.975" "1.027" "0.948" "0.996" "1.002" "1.011" "0.870" "2101.4" "2139.7" "2197.9" "2048.6" "2157.3" "1993.0" "2094.0" "2104.6" "2123.8" "1829.2" "" "" "" "" "" "" "" "" "" "" "1889.4" "1731.4" "1988.1" "1999.7" "1780.2" "1993.0" "1567.9" "1859.0" "1900.4" "653.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8211975543562738760" "False" "High" "IsMasterProtein" "P13984" "General transcription factor IIF subunit 2 OS=Homo sapiens OX=9606 GN=GTF2F2 PE=1 SV=2" "0.000" "False" "44.628" "51" "12" "19" "12" "249" "28.4" "9.23" "66.21" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf02270, Pf17683" "2963" "ENSG00000188342" "GTF2F2" "A6NNS5; hsa:2963; P13984; Q5W0H3" "Eukaryotic transcription initiation" "Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "33" "0" "0.939" "1.021" "1.027" "0.942" "1.027" "0.919" "0.978" "0.958" "0.861" "2646.0" "2485.7" "2700.5" "2718.7" "2493.5" "2716.2" "2432.6" "2587.0" "2534.9" "2278.5" "" "" "" "" "" "" "" "" "" "" "2379.0" "2011.3" "2442.7" "2653.9" "2057.7" "2716.2" "1821.5" "2285.0" "2268.2" "813.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4224605817431316350" "False" "High" "IsMasterProtein" "Q96ST2" "Protein IWS1 homolog OS=Homo sapiens OX=9606 GN=IWS1 PE=1 SV=2" "0.000" "False" "44.610" "19" "14" "19" "14" "819" "91.9" "4.69" "59.80" "14" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "" "Pf08711" "55677" "ENSG00000163166" "IWS1" "hsa:55677; Q2TB65; Q6P157; Q8N3E8; Q96MI7; Q96ST2; Q9NV97; Q9NWH8" "" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex" "3" "0" "1.035" "0.992" "1.030" "1.091" "1.020" "1.022" "1.125" "1.109" "1.278" "942.8" "975.9" "935.7" "971.4" "1028.3" "961.5" "963.5" "1060.8" "1045.2" "1205.1" "" "" "" "" "" "" "" "" "" "" "847.7" "789.7" "846.4" "948.2" "848.6" "961.5" "721.4" "937.0" "935.2" "430.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5384337703464320291" "False" "High" "IsMasterProtein" "Q16822" "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens OX=9606 GN=PCK2 PE=1 SV=4" "0.000" "False" "44.603" "25" "13" "15" "13" "640" "70.7" "7.62" "47.75" "13" "other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf00821, Pf17297" "5106" "ENSG00000100889; ENSG00000285241" "PCK2" "B4DW73; hsa:5106; O43253; Q16822; Q86U01; Q9BV62" "Adipogenesis; Transcription factor regulation in adipogenesis; PPAR signaling pathway; PI3K-Akt signaling pathway; Krebs cycle disorders; DNA damage response (only ATM dependent)" "Gluconeogenesis" "7" "0" "1.020" "0.990" "0.954" "1.036" "0.976" "1.005" "0.949" "1.033" "0.815" "952.6" "972.0" "943.0" "908.7" "986.7" "929.5" "957.6" "903.6" "983.7" "776.6" "" "" "" "" "" "" "" "" "" "" "856.5" "786.5" "853.0" "887.0" "814.2" "929.5" "717.1" "798.1" "880.2" "277.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5970441865792546005" "False" "High" "IsMasterProtein" "P04920" "Anion exchange protein 2 OS=Homo sapiens OX=9606 GN=SLC4A2 PE=1 SV=4" "0.000" "False" "44.577" "12" "11" "12" "11" "1241" "136.9" "6.29" "54.75" "11" "transport;developmental processes;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00955, Pf07565" "6522" "ENSG00000164889" "SLC4A2" "B2R6T0; B4DIT0; D3DX05; F8W682; hsa:6522; P04920; Q45EY5; Q969L3" "Proximal tubule transport" "Bicarbonate transporters" "2" "0" "1.033" "1.023" "0.985" "1.044" "1.040" "1.051" "0.985" "0.986" "0.875" "832.2" "859.8" "851.4" "819.6" "869.1" "865.4" "874.5" "819.9" "820.3" "727.9" "" "" "" "" "" "" "" "" "" "" "748.2" "695.8" "770.1" "800.1" "717.2" "865.4" "654.8" "724.2" "734.0" "259.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2749057131699299074" "False" "High" "IsMasterProtein" "Q9BSY4" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 OS=Homo sapiens OX=9606 GN=CHCHD5 PE=1 SV=1" "0.000" "False" "44.530" "84" "7" "19" "7" "110" "12.4" "6.73" "69.18" "7" "other metabolic processes" "mitochondrion" "" "Pf06747, Pf16860" "84269" "ENSG00000125611" "CHCHD5" "hsa:84269; Q585T4; Q8N8C4; Q9BSY4" "2q13 copy number variation syndrome" "Mitochondrial protein import" "2" "0" "0.913" "0.994" "0.991" "1.026" "1.031" "1.048" "1.065" "1.033" "0.890" "1272.3" "1161.8" "1264.9" "1261.4" "1305.0" "1312.1" "1333.3" "1355.0" "1314.8" "1131.9" "" "" "" "" "" "" "" "" "" "" "1143.9" "940.1" "1144.1" "1231.3" "1076.9" "1312.1" "998.3" "1196.9" "1176.5" "404.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258533483115152097" "False" "High" "IsMasterProtein" "Q53H96" "Pyrroline-5-carboxylate reductase 3 OS=Homo sapiens OX=9606 GN=PYCR3 PE=1 SV=3" "0.000" "False" "44.470" "45" "9" "13" "9" "274" "28.6" "7.72" "57.59" "9" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03807, Pf14748" "65263" "ENSG00000104524; ENSG00000276657" "PYCR3" "B3KMB5; B4DVT6; H0Y6C3; hsa:65263; Q53H96; Q8N3N9; Q96HX4; Q9H896" "" "Glutamate and glutamine metabolism" "1" "0" "1.028" "1.031" "0.932" "1.013" "1.058" "0.968" "1.025" "0.979" "0.841" "846.1" "869.7" "872.4" "788.7" "856.7" "895.3" "819.4" "867.3" "828.2" "711.8" "" "" "" "" "" "" "" "" "" "" "760.8" "703.8" "789.1" "769.9" "707.0" "895.3" "613.6" "766.0" "741.1" "254.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6627286514823912553" "False" "High" "IsMasterProtein" "Q8TEA1" "tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 OS=Homo sapiens OX=9606 GN=NSUN6 PE=1 SV=1" "0.000" "False" "44.449" "27" "10" "13" "10" "469" "51.7" "7.96" "48.11" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf01189" "221078" "ENSG00000241058" "NSUN6" "B0YJ54; hsa:221078; Q8TEA1" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.989" "0.966" "1.011" "1.021" "0.950" "1.013" "0.972" "1.010" "0.921" "798.1" "789.3" "770.7" "806.7" "814.8" "757.8" "808.4" "775.6" "806.2" "734.7" "" "" "" "" "" "" "" "" "" "" "717.6" "638.7" "697.2" "787.5" "672.4" "757.8" "605.3" "685.1" "721.4" "262.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6983483800967602038" "False" "High" "IsMasterProtein" "Q9NVM9" "Integrator complex subunit 13 OS=Homo sapiens OX=9606 GN=INTS13 PE=1 SV=2" "0.000" "False" "44.402" "23" "15" "17" "15" "706" "80.2" "6.70" "57.35" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10221" "55726" "ENSG00000064102" "INTS13" "B4DNK1; hsa:55726; Q86WE2; Q96HM2; Q9BTX2; Q9NTB6; Q9NVM5; Q9NVM9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.014" "0.989" "0.932" "1.042" "0.954" "1.041" "1.002" "0.983" "1.356" "1046.5" "1061.4" "1034.9" "975.1" "1090.8" "997.9" "1089.0" "1048.5" "1029.0" "1419.3" "" "" "" "" "" "" "" "" "" "" "940.9" "858.9" "936.1" "951.8" "900.2" "997.9" "815.4" "926.1" "920.8" "506.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2846560637843554470" "False" "High" "IsMasterProtein" "O14579" "Coatomer subunit epsilon OS=Homo sapiens OX=9606 GN=COPE PE=1 SV=3" "0.000" "False" "44.269" "51" "13" "21" "13" "308" "34.5" "5.12" "79.93" "13" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf04733" "11316" "ENSG00000105669" "COPE" "A6NE29; A6NKA3; hsa:11316; O14579; O76097; Q6IBB8; Q9UGP6" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.967" "0.988" "0.975" "1.031" "0.988" "1.006" "0.999" "1.004" "0.907" "1758.5" "1700.4" "1737.9" "1713.8" "1813.4" "1737.3" "1768.3" "1755.9" "1765.6" "1594.1" "" "" "" "" "" "" "" "" "" "" "1581.0" "1375.9" "1572.0" "1672.9" "1496.5" "1737.3" "1324.1" "1550.9" "1579.8" "569.1" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8361684917289872737" "False" "High" "IsMasterProtein" "Q9BSW2" "EF-hand calcium-binding domain-containing protein 4B OS=Homo sapiens OX=9606 GN=CRACR2A PE=1 SV=2" "0.000" "False" "44.177" "19" "12" "15" "12" "731" "83.1" "5.24" "50.93" "12" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00071, Pf13499" "84766" "ENSG00000130038" "CRACR2A" "B4E1X0; B9EK63; hsa:84766; Q9BSW2" "Vitamin D receptor pathway" "Neutrophil degranulation" "2" "0" "1.029" "1.060" "1.018" "1.087" "1.076" "1.104" "1.063" "1.115" "1.095" "902.2" "928.3" "956.7" "918.8" "980.5" "970.5" "996.1" "959.4" "1005.8" "987.6" "" "" "" "" "" "" "" "" "" "" "811.2" "751.1" "865.3" "896.9" "809.1" "970.5" "745.8" "847.4" "900.0" "352.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295082137940750650" "False" "High" "IsMasterProtein" "O43633" "Charged multivesicular body protein 2a OS=Homo sapiens OX=9606 GN=CHMP2A PE=1 SV=1" "0.000" "False" "44.142" "30" "8" "23" "8" "222" "25.1" "5.97" "77.99" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "27243" "ENSG00000130724" "CHMP2A" "B2R4W6; hsa:27243; O43633; Q3ZTT0" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Lysosome Vesicle Biogenesis; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "10" "0" "1.034" "1.066" "1.023" "1.003" "1.074" "1.039" "1.042" "1.045" "0.800" "1768.2" "1828.1" "1884.7" "1809.3" "1773.2" "1899.6" "1837.5" "1842.9" "1847.2" "1414.2" "" "" "" "" "" "" "" "" "" "" "1589.8" "1479.3" "1704.7" "1766.1" "1463.2" "1899.6" "1375.9" "1627.8" "1652.8" "504.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8124726233717471609" "False" "High" "IsMasterProtein" "P50750" "Cyclin-dependent kinase 9 OS=Homo sapiens OX=9606 GN=CDK9 PE=1 SV=3" "0.000" "False" "44.127" "28" "9" "19" "7" "372" "42.8" "8.79" "64.30" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069" "1025" "ENSG00000136807" "CDK9" "hsa:1025; P50750; Q5JU24; Q5JU25; Q5U006; Q96TF1" "MicroRNAs in cardiomyocyte hypertrophy; IL-9 signaling pathway; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; Male infertility" "Estrogen-dependent gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; Interactions of Tat with host cellular proteins" "20" "0" "1.029" "1.122" "1.002" "1.032" "1.178" "1.041" "0.957" "1.065" "1.153" "1099.6" "1131.8" "1233.7" "1102.0" "1134.7" "1295.1" "1145.2" "1052.6" "1170.9" "1267.3" "" "" "" "" "" "" "" "" "" "" "988.6" "915.8" "1115.9" "1075.7" "936.4" "1295.1" "857.5" "929.7" "1047.7" "452.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1056370544189754053" "False" "High" "IsMasterProtein" "P28065" "Proteasome subunit beta type-9 OS=Homo sapiens OX=9606 GN=PSMB9 PE=1 SV=2" "0.000" "False" "44.099" "45" "8" "16" "8" "219" "23.3" "5.03" "59.38" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00227" "5698" "ENSG00000239836; ENSG00000240065; ENSG00000240118; ENSG00000240508; ENSG00000242711; ENSG00000243067; ENSG00000243594; ENSG00000243958" "PSMB9" "B0V0T1; hsa:5698; P28065; Q16523; Q5JNW4" "Proteasome degradation; Type II interferon signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "1.038" "0.994" "1.006" "1.025" "0.963" "1.032" "1.006" "1.030" "0.852" "1023.3" "1062.3" "1017.0" "1029.1" "1048.5" "984.9" "1055.6" "1029.0" "1053.9" "871.8" "" "" "" "" "" "" "" "" "" "" "920.0" "859.6" "920.0" "1004.5" "865.2" "984.9" "790.4" "908.8" "943.0" "311.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562361449972294003" "False" "High" "IsMasterProtein" "O00425" "Insulin-like growth factor 2 mRNA-binding protein 3 OS=Homo sapiens OX=9606 GN=IGF2BP3 PE=1 SV=2" "0.000" "False" "44.094" "24" "13" "19" "13" "579" "63.7" "8.87" "64.43" "13" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf00076" "10643" "ENSG00000136231" "IGF2BP3" "A0A4Z5; hsa:10643; O00425; Q63HM0; Q6MZZ2; Q86VB1" "" "Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA" "1" "0" "0.996" "1.003" "0.865" "0.941" "0.997" "1.023" "0.898" "0.959" "2.686" "1012.1" "1008.4" "1015.0" "875.5" "952.5" "1009.3" "1034.9" "908.6" "970.9" "2718.7" "" "" "" "" "" "" "" "" "" "" "909.9" "816.0" "918.1" "854.6" "786.0" "1009.3" "774.9" "802.5" "868.8" "970.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8011732413234136033" "False" "High" "IsMasterProtein" "Q9UJX4" "Anaphase-promoting complex subunit 5 OS=Homo sapiens OX=9606 GN=ANAPC5 PE=1 SV=2" "0.000" "False" "44.062" "17" "12" "14" "12" "755" "85.0" "6.87" "45.43" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf12862, Pf21371" "51433" "ENSG00000089053" "ANAPC5" "E9PFB2; hsa:51433; Q8N4H7; Q9BQD4; Q9UJX4" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.990" "1.007" "0.937" "0.964" "0.976" "0.938" "0.979" "0.950" "0.983" "1269.7" "1257.0" "1278.3" "1189.8" "1223.5" "1239.7" "1190.4" "1243.1" "1206.3" "1247.9" "" "" "" "" "" "" "" "" "" "" "1141.6" "1017.1" "1156.3" "1161.4" "1009.6" "1239.7" "891.4" "1098.0" "1079.4" "445.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9215017324203505863" "False" "High" "IsMasterProtein" "Q6Y7W6" "GRB10-interacting GYF protein 2 OS=Homo sapiens OX=9606 GN=GIGYF2 PE=1 SV=1" "0.000" "False" "44.050" "11" "15" "16" "14" "1299" "150.0" "5.54" "56.18" "15" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02213" "26058" "ENSG00000204120" "GIGYF2" "A6H8W4; B9EG55; E9PBB0; hsa:26058; O75137; Q6Y7W6; Q7Z2Z8; Q7Z3I2; Q96HU4; Q9NV82" "VEGFA-VEGFR2 signaling" "" "1" "1" "1.035" "1.041" "1.021" "1.043" "1.111" "1.109" "1.019" "0.984" "1.562" "953.4" "986.7" "992.5" "973.4" "994.5" "1059.3" "1057.2" "971.1" "938.4" "1489.0" "" "" "" "" "" "" "" "" "" "" "857.2" "798.4" "897.8" "950.2" "820.7" "1059.3" "791.6" "857.8" "839.7" "531.5" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2410269861090895387" "False" "High" "IsMasterProtein" "Q9NZT2" "Opioid growth factor receptor OS=Homo sapiens OX=9606 GN=OGFR PE=1 SV=3" "0.000" "False" "44.048" "20" "10" "14" "10" "677" "73.3" "4.84" "57.38" "10" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf04664, Pf04680" "11054" "ENSG00000060491" "OGFR" "hsa:11054; O96029; Q4VXW5; Q96CM2; Q9BQW1; Q9H4H0; Q9H7J5; Q9NZT2; Q9NZT3; Q9NZT4" "" "" "0" "0" "0.997" "0.962" "0.988" "0.947" "0.933" "1.003" "0.855" "0.912" "4.581" "779.0" "776.7" "749.8" "770.0" "737.4" "726.9" "781.5" "665.8" "710.9" "3568.7" "" "" "" "" "" "" "" "" "" "" "700.4" "628.5" "678.2" "751.6" "608.5" "726.9" "585.1" "588.1" "636.1" "1273.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1641780535886565556" "False" "High" "IsMasterProtein" "Q7L1T6" "Cytochrome b5 reductase 4 OS=Homo sapiens OX=9606 GN=CYB5R4 PE=1 SV=1" "0.000" "False" "44.010" "25" "12" "16" "12" "521" "59.4" "7.72" "57.60" "12" "cell-cell signaling;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00173, Pf00175, Pf00970, Pf04969" "51167" "ENSG00000065615" "CYB5R4" "B1AEM2; hsa:51167; Q5TGI9; Q7L1T6; Q9NUE4; Q9UHI9" "Oxidation by cytochrome P450" "Erythrocytes take up carbon dioxide and release oxygen" "2" "0" "1.029" "0.985" "0.962" "1.011" "0.984" "1.597" "0.998" "1.089" "1.068" "638.2" "657.0" "628.9" "614.2" "645.1" "628.2" "1019.2" "637.2" "695.2" "681.4" "" "" "" "" "" "" "" "" "" "" "573.8" "531.6" "568.9" "599.6" "532.4" "628.2" "763.2" "562.8" "622.1" "243.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7369433181564394735" "False" "High" "IsMasterProtein" "P08708" "Small ribosomal subunit protein eS17 OS=Homo sapiens OX=9606 GN=RPS17 PE=1 SV=2" "0.000" "False" "43.993" "40" "6" "15" "6" "135" "15.5" "9.85" "65.39" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00833" "6218" "ENSG00000182774; ENSG00000278229" "RPS17" "B2R4U4; hsa:6218; P08708; P0CW22" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.034" "1.063" "0.968" "0.979" "1.038" "0.934" "0.999" "1.001" "1.496" "1217.1" "1259.0" "1293.6" "1178.5" "1191.7" "1263.1" "1137.3" "1215.9" "1218.4" "1820.5" "" "" "" "" "" "" "" "" "" "" "1094.3" "1018.7" "1170.1" "1150.4" "983.4" "1263.1" "851.6" "1074.0" "1090.3" "649.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5796509123597455273" "False" "High" "IsMasterProtein" "Q14558" "Phosphoribosyl pyrophosphate synthase-associated protein 1 OS=Homo sapiens OX=9606 GN=PRPSAP1 PE=1 SV=2" "0.000" "False" "43.898" "32" "8" "13" "6" "356" "39.4" "7.20" "61.17" "8" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf13793, Pf14572" "5635" "ENSG00000161542" "PRPSAP1" "B2R6M4; hsa:5635; Q14558; Q96H06" "" "" "0" "0" "1.027" "1.066" "1.001" "1.082" "1.091" "1.069" "1.055" "1.079" "0.928" "554.1" "568.9" "590.6" "554.5" "599.3" "604.6" "592.0" "584.6" "597.6" "514.0" "" "" "" "" "" "" "" "" "" "" "498.2" "460.3" "534.2" "541.3" "494.5" "604.6" "443.3" "516.3" "534.7" "183.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5696513608973606523" "False" "High" "IsMasterProtein" "Q86VQ1" "Glucocorticoid-induced transcript 1 protein OS=Homo sapiens OX=9606 GN=GLCCI1 PE=1 SV=1" "0.000" "False" "43.881" "23" "10" "15" "10" "547" "58.0" "9.44" "57.49" "10" "" "other cell component" "" "Pf15388" "113263" "ENSG00000106415" "GLCCI1" "A4D103; hsa:113263; Q86VQ1; Q96FD0" "" "" "0" "0" "0.936" "0.806" "0.984" "1.036" "0.869" "0.973" "1.024" "0.872" "0.833" "1176.6" "1100.9" "948.8" "1158.1" "1219.0" "1022.4" "1144.6" "1205.1" "1026.4" "980.4" "" "" "" "" "" "" "" "" "" "" "1057.8" "890.8" "858.2" "1130.5" "1005.9" "1022.4" "857.0" "1064.4" "918.4" "350.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7990537509462567326" "False" "High" "IsMasterProtein" "P16298" "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PPP3CB PE=1 SV=2" "0.000" "False" "43.834" "17" "9" "17" "4" "524" "59.0" "5.91" "61.56" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00149" "5532" "ENSG00000107758" "PPP3CB" "hsa:5532; P16298; P16299; Q5F2F9; Q8N1F0; Q8N3W4" "Physiological and pathological hypertrophy of the heart; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; ROBO receptors bind AKAP5" "16" "0" "1.052" "0.984" "0.979" "1.080" "1.006" "1.042" "1.049" "1.034" "0.961" "614.9" "647.0" "605.1" "602.0" "664.0" "618.9" "640.9" "645.3" "635.9" "591.1" "" "" "" "" "" "" "" "" "" "" "552.9" "523.5" "547.4" "587.7" "547.9" "618.9" "479.9" "569.9" "569.0" "211.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2630091394541072843" "False" "High" "IsMasterProtein" "Q9P2Y5" "UV radiation resistance-associated gene protein OS=Homo sapiens OX=9606 GN=UVRAG PE=1 SV=1" "0.000" "False" "43.817" "20" "14" "17" "14" "699" "78.1" "8.29" "60.57" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf10186" "7405" "ENSG00000198382" "UVRAG" "B3KTC1; hsa:7405; O00392; Q9P2Y5" "Nanoparticle triggered autophagic cell death; Autophagy" "Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; SARS-CoV-2 modulates autophagy" "6" "0" "1.065" "1.003" "1.019" "1.052" "1.056" "1.050" "1.013" "1.056" "1.076" "883.6" "940.7" "886.1" "900.5" "929.2" "933.4" "927.7" "894.9" "933.5" "950.4" "" "" "" "" "" "" "" "" "" "" "794.5" "761.2" "801.5" "879.0" "766.8" "933.4" "694.7" "790.4" "835.3" "339.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1466786555444396810" "False" "High" "IsMasterProtein" "Q12933" "TNF receptor-associated factor 2 OS=Homo sapiens OX=9606 GN=TRAF2 PE=1 SV=2" "0.000" "False" "43.790" "23" "11" "15" "11" "501" "55.8" "7.53" "51.92" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02176, Pf16673, Pf21341, Pf21355" "7186" "ENSG00000127191" "TRAF2" "A8K107; B4DPJ7; hsa:7186; Q12933; Q7Z337; Q96NT2" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; p38 MAPK signaling pathway; Nonalcoholic fatty liver disease; Small cell lung cancer; 16p11.2 proximal deletion syndrome; 16p11.2 distal deletion syndrome; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Pleural mesothelioma; Alzheimer's disease; 1p36 copy number variation syndrome; 13q12.12 copy number variation; 8q11.23 (RB1CC1) copy number variation" "Ub-specific processing proteases; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TRAF6 mediated NF-kB activation; Regulation of NF-kappa B signaling; TNFR1-induced proapoptotic signaling; TRAF6 mediated IRF7 activation; Defective RIPK1-mediated regulated necrosis" "37" "0" "1.023" "0.983" "0.987" "1.060" "0.946" "1.023" "1.020" "0.969" "0.863" "1762.7" "1803.1" "1732.6" "1739.9" "1868.2" "1667.0" "1802.9" "1798.0" "1708.9" "1521.4" "" "" "" "" "" "" "" "" "" "" "1584.9" "1459.0" "1567.2" "1698.4" "1541.6" "1667.0" "1350.0" "1588.1" "1529.1" "543.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "683503187076847751" "False" "High" "IsMasterProtein" "Q96AZ6" "Interferon-stimulated gene 20 kDa protein OS=Homo sapiens OX=9606 GN=ISG20 PE=1 SV=2" "0.000" "False" "43.727" "51" "8" "13" "8" "181" "20.4" "8.92" "48.78" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "3669" "ENSG00000172183" "ISG20" "hsa:3669; O00441; O00586; Q96AZ6" "" "Interferon alpha/beta signaling" "1" "0" "1.021" "1.038" "0.975" "1.052" "0.989" "1.013" "1.037" "0.920" "1.074" "700.3" "715.1" "726.8" "682.8" "736.9" "692.4" "709.7" "726.4" "644.6" "751.9" "" "" "" "" "" "" "" "" "" "" "629.7" "578.6" "657.4" "666.5" "608.1" "692.4" "531.4" "641.6" "576.8" "268.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7652533075202528091" "False" "High" "IsMasterProtein" "Q92734" "Protein TFG OS=Homo sapiens OX=9606 GN=TFG PE=1 SV=2" "0.000" "False" "43.717" "34" "9" "16" "9" "400" "43.4" "5.10" "63.25" "9" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00564" "10342" "ENSG00000114354" "TFG" "D3DN49; G5E9V1; hsa:10342; K0J5S8; K0J6K2; Q15656; Q92734; Q969I2" "" "Signaling by ALK fusions and activated point mutants; COPII-mediated vesicle transport" "2" "0" "1.007" "0.926" "0.978" "1.095" "1.008" "1.021" "1.031" "1.041" "0.849" "1161.0" "1169.5" "1075.0" "1135.9" "1270.8" "1170.8" "1185.5" "1197.3" "1208.6" "985.2" "" "" "" "" "" "" "" "" "" "" "1043.8" "946.3" "972.4" "1108.8" "1048.7" "1170.8" "887.7" "1057.5" "1081.4" "351.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208220757799786637" "False" "High" "IsMasterProtein" "Q9BTC8" "Metastasis-associated protein MTA3 OS=Homo sapiens OX=9606 GN=MTA3 PE=1 SV=2" "0.000" "False" "43.691" "20" "11" "20" "6" "594" "67.5" "8.57" "66.54" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "57504" "ENSG00000057935" "MTA3" "hsa:57504; Q9BTC8; Q9NSP2; Q9ULF4" "Pre-implantation embryo; Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "7" "1" "1.084" "0.980" "0.971" "1.047" "1.042" "1.091" "0.917" "0.979" "1.963" "818.2" "886.8" "802.1" "794.5" "856.4" "852.5" "892.8" "750.4" "800.7" "1606.5" "" "" "" "" "" "" "" "" "" "" "735.7" "717.6" "725.5" "775.5" "706.7" "852.5" "668.5" "662.8" "716.4" "573.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8297311667808919408" "False" "High" "IsMasterProtein" "Q14651" "Plastin-1 OS=Homo sapiens OX=9606 GN=PLS1 PE=1 SV=2" "0.000" "False" "43.677" "11" "6" "36" "2" "629" "70.2" "5.41" "128.06" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00036, Pf00307, Pf13405" "5357" "ENSG00000120756" "PLS1" "A8K2Q1; D3DNG3; hsa:5357; Q14651; Q8NEG6" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.019" "1.033" "0.979" "1.074" "1.141" "1.107" "1.050" "0.995" "0.912" "203.9" "207.8" "210.6" "199.6" "219.0" "232.7" "225.6" "214.0" "202.8" "185.9" "" "" "" "" "" "" "" "" "" "" "183.3" "168.1" "190.5" "194.8" "180.7" "232.7" "168.9" "189.0" "181.5" "66.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-105519067553436175" "False" "High" "IsMasterProtein" "Q04323" "UBX domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBXN1 PE=1 SV=2" "0.000" "False" "43.614" "40" "8" "15" "8" "297" "33.3" "5.25" "63.21" "8" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00627, Pf00789" "51035" "ENSG00000162191" "UBXN1" "hsa:51035; Q04323; Q9BV93; Q9BVV5" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "2" "0" "0.903" "0.937" "0.980" "0.981" "0.952" "0.999" "0.998" "0.989" "1.034" "1190.4" "1074.9" "1115.5" "1166.8" "1168.2" "1133.6" "1189.3" "1187.8" "1177.7" "1230.9" "" "" "" "" "" "" "" "" "" "" "1070.3" "869.7" "1009.0" "1138.9" "964.0" "1133.6" "890.5" "1049.2" "1053.8" "439.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973813700341614243" "False" "High" "IsMasterProtein" "Q96SB4" "SRSF protein kinase 1 OS=Homo sapiens OX=9606 GN=SRPK1 PE=1 SV=2" "0.000" "False" "43.536" "18" "12" "15" "9" "655" "74.3" "6.16" "54.36" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6732" "ENSG00000096063" "SRPK1" "B4DS61; hsa:6732; Q12890; Q5R364; Q5R365; Q8IY12; Q96SB4" "VEGFA-VEGFR2 signaling; mRNA processing" "Replacement of protamines by nucleosomes in the male pronucleus; Maturation of nucleoprotein" "4" "1" "1.019" "1.086" "0.933" "1.028" "1.215" "0.996" "0.897" "0.956" "1.256" "1222.6" "1245.4" "1327.5" "1140.7" "1257.1" "1484.9" "1218.1" "1097.0" "1169.4" "1535.4" "" "" "" "" "" "" "" "" "" "" "1099.3" "1007.7" "1200.8" "1113.5" "1037.4" "1484.9" "912.1" "969.0" "1046.4" "548.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4992003344612717305" "False" "High" "IsMasterProtein" "P30260" "Cell division cycle protein 27 homolog OS=Homo sapiens OX=9606 GN=CDC27 PE=1 SV=2" "0.000" "False" "43.504" "14" "12" "13" "12" "824" "91.8" "7.02" "47.62" "12" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00515, Pf12895" "996" "ENSG00000004897" "CDC27" "G3V1C4; hsa:996; P30260; Q16349; Q96F35" "Cell cycle; 2q21.1 copy number variation syndrome" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "20" "0" "1.052" "1.003" "0.922" "0.962" "1.005" "0.948" "0.985" "1.018" "0.935" "1156.3" "1216.1" "1159.7" "1065.8" "1112.6" "1162.2" "1096.0" "1139.4" "1177.5" "1080.6" "" "" "" "" "" "" "" "" "" "" "1039.6" "984.0" "1049.0" "1040.3" "918.1" "1162.2" "820.6" "1006.4" "1053.6" "385.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6302515266357767192" "False" "High" "IsMasterProtein" "Q9NR46" "Endophilin-B2 OS=Homo sapiens OX=9606 GN=SH3GLB2 PE=1 SV=1" "0.000" "False" "43.498" "32" "11" "14" "11" "395" "43.9" "5.99" "57.86" "11" "cell organization and biogenesis" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03114, Pf14604" "56904" "ENSG00000148341" "SH3GLB2" "A6NC47; A8MPS4; hsa:56904; Q8WY61; Q96JH9; Q9NR46" "" "" "0" "0" "0.992" "0.986" "1.042" "1.035" "1.007" "1.039" "1.043" "1.027" "1.248" "967.6" "959.7" "954.5" "1008.4" "1001.8" "974.9" "1004.9" "1008.9" "993.5" "1207.7" "" "" "" "" "" "" "" "" "" "" "870.0" "776.6" "863.4" "984.4" "826.7" "974.9" "752.4" "891.1" "889.0" "431.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4682343242687865588" "False" "High" "IsMasterProtein" "O43818" "U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens OX=9606 GN=RRP9 PE=1 SV=1" "0.000" "False" "43.453" "28" "12" "15" "12" "475" "51.8" "7.85" "50.67" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400" "9136" "ENSG00000114767" "RRP9" "B2R996; hsa:9136; O43818; Q8IZ30" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.059" "1.137" "1.076" "1.110" "1.179" "1.047" "1.017" "1.133" "0.658" "712.4" "754.4" "810.3" "766.6" "790.8" "840.3" "746.0" "724.4" "807.3" "469.0" "" "" "" "" "" "" "" "" "" "" "640.6" "610.5" "732.9" "748.3" "652.6" "840.3" "558.6" "639.8" "722.4" "167.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4889317708786741676" "False" "High" "IsMasterProtein" "Q96AT1" "Uncharacterized protein KIAA1143 OS=Homo sapiens OX=9606 GN=KIAA1143 PE=1 SV=2" "0.000" "False" "43.408" "62" "11" "15" "11" "154" "17.5" "6.11" "62.23" "11" "" "" "" "Pf15377" "57456" "ENSG00000163807; ENSG00000281665" "KIAA1143" "A8K0I4; hsa:57456; Q96AT1; Q96HJ8; Q9ULS7" "" "" "0" "0" "0.877" "0.997" "0.944" "0.930" "0.938" "0.939" "0.961" "0.970" "0.719" "2044.2" "1792.0" "2037.3" "1929.0" "1902.1" "1916.7" "1918.9" "1963.7" "1982.7" "1469.9" "" "" "" "" "" "" "" "" "" "" "1838.0" "1450.0" "1842.8" "1883.0" "1569.6" "1916.7" "1436.8" "1734.4" "1774.1" "524.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3153714913884480543" "False" "High" "IsMasterProtein" "Q8TAE8" "Large ribosomal subunit protein mL64 OS=Homo sapiens OX=9606 GN=GADD45GIP1 PE=1 SV=1" "0.000" "False" "43.407" "58" "10" "14" "10" "222" "25.4" "10.02" "50.32" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf10147" "90480" "ENSG00000179271" "GADD45GIP1" "hsa:90480; Q8IVM3; Q8TAE8; Q8TE51; Q969P9; Q9BSM6" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.980" "0.951" "0.923" "0.961" "0.976" "1.008" "1.043" "0.967" "0.926" "1053.4" "1031.9" "1002.0" "972.3" "1012.0" "1028.2" "1062.0" "1098.9" "1018.9" "975.3" "" "" "" "" "" "" "" "" "" "" "947.1" "835.0" "906.4" "949.1" "835.1" "1028.2" "795.2" "970.6" "911.7" "348.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4676575217961373957" "False" "High" "IsMasterProtein" "P63098" "Calcineurin subunit B type 1 OS=Homo sapiens OX=9606 GN=PPP3R1 PE=1 SV=2" "0.000" "False" "43.405" "58" "7" "15" "7" "170" "19.3" "4.81" "69.68" "7" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13499" "5534" "ENSG00000221823" "PPP3R1" "B2RC10; B5MDU4; hsa:5534; P06705; P15117; P63098; Q08044; Q53SL0" "Energy metabolism; Transcription factors regulate miRNAs related to cardiac hypertrophy; Alzheimer's disease and miRNA effects; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Vitamin D in inflammatory diseases; Regucalcin in proximal tubule epithelial kidney cells; Alzheimer's disease" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; DARPP-32 events; Activation of BAD and translocation to mitochondria" "15" "0" "0.865" "0.944" "0.906" "0.987" "0.938" "0.971" "1.081" "0.991" "0.809" "1928.9" "1668.5" "1820.0" "1747.3" "1904.5" "1808.5" "1873.1" "2085.1" "1911.6" "1561.0" "" "" "" "" "" "" "" "" "" "" "1734.3" "1350.1" "1646.2" "1705.6" "1571.6" "1808.5" "1402.5" "1841.7" "1710.5" "557.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "61926280635528933" "False" "High" "IsMasterProtein" "O60885" "Bromodomain-containing protein 4 OS=Homo sapiens OX=9606 GN=BRD4 PE=1 SV=2" "0.000" "False" "43.391" "11" "15" "15" "10" "1362" "152.1" "9.19" "52.95" "15" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf17035, Pf17105" "23476" "ENSG00000141867" "BRD4" "hsa:23476; O60433; O60885; Q4G0X8; Q86YS8; Q96PD3" "VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome" "Potential therapeutics for SARS" "3" "3" "0.975" "1.015" "0.981" "1.012" "1.010" "0.959" "0.918" "0.994" "2.972" "875.2" "853.0" "888.3" "858.9" "885.5" "883.9" "838.9" "803.4" "870.0" "2601.2" "" "" "" "" "" "" "" "" "" "" "786.9" "690.2" "803.5" "838.4" "730.8" "883.9" "628.2" "709.6" "778.5" "928.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9172177916429743793" "False" "High" "IsMasterProtein" "Q99816" "Tumor susceptibility gene 101 protein OS=Homo sapiens OX=9606 GN=TSG101 PE=1 SV=2" "0.000" "False" "43.378" "28" "10" "15" "10" "390" "43.9" "6.46" "54.20" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf05743, Pf09454" "7251" "ENSG00000074319" "TSG101" "hsa:7251; Q99816; Q9BUM5" "Ebola virus infection in host; 7q11.23 copy number variation syndrome" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "7" "0" "1.043" "1.027" "1.076" "1.083" "1.044" "0.975" "1.010" "1.069" "1.050" "1269.9" "1325.1" "1304.4" "1366.0" "1375.9" "1325.6" "1237.9" "1282.5" "1357.4" "1333.4" "" "" "" "" "" "" "" "" "" "" "1141.8" "1072.2" "1179.9" "1333.4" "1135.4" "1325.6" "926.9" "1132.8" "1214.6" "476.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851327045355939363" "False" "High" "IsMasterProtein" "P16401" "Histone H1.5 OS=Homo sapiens OX=9606 GN=H1-5 PE=1 SV=3" "0.000" "False" "43.345" "30" "9" "21" "6" "226" "22.6" "10.92" "77.89" "9" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "3009" "ENSG00000184357" "H1-5" "hsa:3009; P16401; Q14529; Q3MJ42" "" "Apoptosis induced DNA fragmentation; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "0.990" "0.995" "0.993" "0.991" "0.960" "0.931" "0.960" "0.882" "0.785" "2323.8" "2301.2" "2312.0" "2308.0" "2303.7" "2231.8" "2163.9" "2230.5" "2050.1" "1823.7" "" "" "" "" "" "" "" "" "" "" "2089.3" "1862.0" "2091.3" "2253.0" "1901.0" "2231.8" "1620.3" "1970.1" "1834.4" "651.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6418921267369266529" "False" "High" "IsMasterProtein" "P31321" "cAMP-dependent protein kinase type I-beta regulatory subunit OS=Homo sapiens OX=9606 GN=PRKAR1B PE=1 SV=4" "0.000" "False" "43.246" "28" "9" "16" "7" "381" "43.0" "5.71" "59.62" "9" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00027, Pf02197" "5575" "ENSG00000188191" "PRKAR1B" "hsa:5575; P31321; Q8N422" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Cannabinoid receptor signaling; Lipid metabolism pathway; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Hedgehog 'off' state; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase" "21" "0" "1.026" "0.964" "1.014" "1.074" "0.942" "1.028" "1.019" "0.988" "1.103" "886.5" "909.7" "854.5" "898.9" "952.2" "834.9" "911.4" "903.3" "876.1" "977.7" "" "" "" "" "" "" "" "" "" "" "797.1" "736.1" "773.0" "877.5" "785.8" "834.9" "682.4" "797.9" "783.9" "349.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8869464350434744721" "False" "High" "IsMasterProtein" "O95372" "Acyl-protein thioesterase 2 OS=Homo sapiens OX=9606 GN=LYPLA2 PE=1 SV=1" "0.000" "False" "43.186" "41" "7" "14" "7" "231" "24.7" "7.23" "53.98" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02230" "11313" "ENSG00000011009" "LYPLA2" "hsa:11313; O95372; Q7Z4Z2" "" "L1CAM interactions" "1" "0" "1.032" "1.027" "1.040" "1.055" "1.005" "1.059" "1.099" "1.034" "0.931" "1387.0" "1431.6" "1424.1" "1441.8" "1463.5" "1394.1" "1468.2" "1524.0" "1434.1" "1291.9" "" "" "" "" "" "" "" "" "" "" "1247.1" "1158.4" "1288.2" "1407.4" "1207.7" "1394.1" "1099.4" "1346.1" "1283.2" "461.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5315083588279200367" "False" "High" "IsMasterProtein" "Q96FZ2" "Abasic site processing protein HMCES OS=Homo sapiens OX=9606 GN=HMCES PE=1 SV=1" "0.000" "False" "43.184" "35" "11" "13" "11" "354" "40.5" "8.15" "50.16" "11" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf02586" "56941" "ENSG00000183624" "HMCES" "A6NJR9; hsa:56941; Q96FZ2; Q96G34; Q9NRP3" "" "" "0" "0" "0.962" "0.914" "0.982" "1.018" "0.899" "1.063" "0.989" "0.930" "2.291" "1304.4" "1255.2" "1192.2" "1281.0" "1328.5" "1172.8" "1386.0" "1290.3" "1213.7" "2988.7" "" "" "" "" "" "" "" "" "" "" "1172.8" "1015.7" "1078.4" "1250.5" "1096.3" "1172.8" "1037.8" "1139.6" "1086.0" "1066.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1858767456070720034" "False" "High" "IsMasterProtein" "P55735" "Protein SEC13 homolog OS=Homo sapiens OX=9606 GN=SEC13 PE=1 SV=3" "0.000" "False" "43.166" "32" "7" "14" "7" "322" "35.5" "5.48" "59.00" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "6396" "ENSG00000157020" "SEC13" "A8MV37; B4DXJ1; hsa:6396; P55735; Q5BJF0; Q9BRM6; Q9BUG7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Separation of Sister Chromatids; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; Amino acids regulate mTORC1; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "40" "0" "0.997" "0.996" "0.908" "1.035" "1.015" "1.027" "0.997" "1.028" "1.076" "1116.9" "1113.5" "1112.6" "1014.6" "1156.4" "1133.9" "1146.8" "1113.7" "1147.9" "1201.4" "" "" "" "" "" "" "" "" "" "" "1004.2" "901.0" "1006.3" "990.3" "954.3" "1133.9" "858.7" "983.7" "1027.1" "428.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8034699390765478794" "False" "High" "IsMasterProtein" "Q9UID3" "Vacuolar protein sorting-associated protein 51 homolog OS=Homo sapiens OX=9606 GN=VPS51 PE=1 SV=2" "0.000" "False" "43.166" "16" "12" "14" "12" "782" "86.0" "6.47" "46.90" "12" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08700" "738" "ENSG00000149823" "VPS51" "hsa:738; Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3; Q9UID3" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.017" "0.958" "0.948" "1.055" "0.982" "1.055" "0.962" "0.987" "1.158" "1162.8" "1182.7" "1114.0" "1102.3" "1227.1" "1141.4" "1226.7" "1119.0" "1148.2" "1346.7" "" "" "" "" "" "" "" "" "" "" "1045.5" "957.0" "1007.6" "1076.0" "1012.6" "1141.4" "918.5" "988.4" "1027.4" "480.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6790579379401263319" "False" "High" "IsMasterProtein" "Q8IU85" "Calcium/calmodulin-dependent protein kinase type 1D OS=Homo sapiens OX=9606 GN=CAMK1D PE=1 SV=1" "0.000" "False" "43.158" "27" "9" "15" "5" "385" "42.9" "7.21" "60.79" "9" "other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "57118" "ENSG00000183049" "CAMK1D" "B0YIY0; hsa:57118; Q8IU85; Q9HD31" "" "" "0" "4" "1.011" "0.966" "0.964" "1.060" "0.984" "1.026" "1.031" "1.020" "1.010" "1261.0" "1274.6" "1218.1" "1216.2" "1336.9" "1240.8" "1293.4" "1299.7" "1285.8" "1273.9" "" "" "" "" "" "" "" "" "" "" "1133.8" "1031.4" "1101.8" "1187.2" "1103.3" "1240.8" "968.4" "1148.0" "1150.5" "454.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4849374493010714997" "False" "High" "IsMasterProtein" "Q92673" "Sortilin-related receptor OS=Homo sapiens OX=9606 GN=SORL1 PE=1 SV=2" "0.000" "False" "43.152" "7" "15" "16" "15" "2214" "248.3" "5.55" "47.72" "15" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00041, Pf00057, Pf00058, Pf15901, Pf15902" "6653" "ENSG00000137642" "SORL1" "B2RNX7; hsa:6653; Q92673; Q92856" "" "Amyloid fiber formation" "1" "0" "0.962" "0.913" "0.966" "1.055" "0.954" "0.990" "0.896" "0.910" "0.854" "518.9" "499.2" "473.7" "501.2" "547.6" "494.9" "513.9" "464.7" "472.2" "443.3" "" "" "" "" "" "" "" "" "" "" "466.5" "403.9" "428.5" "489.3" "451.9" "494.9" "384.8" "410.5" "422.5" "158.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719545438223687688" "False" "High" "IsMasterProtein" "Q9NWV8" "BRISC and BRCA1-A complex member 1 OS=Homo sapiens OX=9606 GN=BABAM1 PE=1 SV=1" "0.000" "False" "43.141" "43" "10" "13" "10" "329" "36.5" "4.64" "55.40" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "" "29086" "ENSG00000105393" "BABAM1" "A8MQT0; B4DRY9; B4DVR1; hsa:29086; Q6FIA0; Q9NWV8; Q9P018" "5q35 copy number variation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.011" "0.963" "1.029" "1.052" "1.010" "1.014" "1.014" "1.021" "1.131" "749.1" "757.0" "721.4" "771.1" "788.3" "756.9" "759.7" "759.2" "765.0" "847.4" "" "" "" "" "" "" "" "" "" "" "673.5" "612.5" "652.5" "752.7" "650.5" "756.9" "568.8" "670.6" "684.6" "302.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7469427958651967746" "False" "High" "IsMasterProtein" "Q9GZL7" "Ribosome biogenesis protein WDR12 OS=Homo sapiens OX=9606 GN=WDR12 PE=1 SV=2" "0.000" "False" "43.104" "35" "13" "15" "13" "423" "47.7" "5.90" "49.91" "13" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08154" "55759" "ENSG00000138442" "WDR12" "B3KPA9; hsa:55759; Q96HU0; Q9GZL7; Q9NV80; Q9NYI8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.122" "1.146" "1.068" "1.090" "1.175" "1.116" "1.094" "1.190" "1.128" "913.5" "1025.4" "1047.3" "976.0" "995.6" "1073.1" "1019.3" "999.5" "1087.1" "1030.5" "" "" "" "" "" "" "" "" "" "" "821.3" "829.7" "947.3" "952.7" "821.6" "1073.1" "763.2" "882.8" "972.7" "367.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9033657698734280587" "False" "High" "IsMasterProtein" "Q9UQ16" "Dynamin-3 OS=Homo sapiens OX=9606 GN=DNM3 PE=1 SV=4" "0.000" "False" "43.079" "11" "10" "28" "1" "869" "97.7" "8.35" "76.58" "10" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00169, Pf00350, Pf01031, Pf02212" "26052" "ENSG00000197959" "DNM3" "A9Z1Y1; hsa:26052; O14982; O95555; Q1MTM8; Q5W129; Q6P2G1; Q9H0P3; Q9H548; Q9NQ68; Q9NQN6; Q9UQ16" "Synaptic vesicle pathway; Alstrom syndrome; 15q25 copy number variation" "MHC class II antigen presentation; Recycling pathway of L1; Toll Like Receptor 4 (TLR4) Cascade; Clathrin-mediated endocytosis; Retrograde neurotrophin signalling" "8" "0" "1.101" "0.930" "1.027" "0.960" "0.852" "0.926" "0.836" "0.938" "0.818" "79.2" "87.2" "73.7" "81.3" "76.1" "67.5" "73.3" "66.2" "74.3" "64.8" "" "" "" "" "" "" "" "" "" "" "71.2" "70.5" "66.6" "79.4" "62.8" "67.5" "54.9" "58.4" "66.5" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7829507115951982075" "False" "High" "IsMasterProtein" "P19387" "DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens OX=9606 GN=POLR2C PE=1 SV=2" "0.000" "False" "43.017" "37" "7" "12" "7" "275" "31.4" "4.92" "55.00" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "5432" "ENSG00000102978" "POLR2C" "hsa:5432; O15161; P19387" "Pyrimidine metabolism; Eukaryotic transcription initiation; Primary ovarian insufficiency" "RNA polymerase II transcribes snRNA genes; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "44" "0" "0.941" "0.949" "1.003" "0.990" "0.968" "0.980" "1.072" "0.966" "1.000" "944.4" "888.3" "896.0" "947.7" "935.4" "914.0" "925.9" "1012.4" "912.5" "944.2" "" "" "" "" "" "" "" "" "" "" "849.1" "718.8" "810.4" "925.1" "771.9" "914.0" "693.3" "894.2" "816.5" "337.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449077897622524501" "False" "High" "IsMasterProtein" "O95551" "Tyrosyl-DNA phosphodiesterase 2 OS=Homo sapiens OX=9606 GN=TDP2 PE=1 SV=1" "0.000" "False" "43.011" "29" "8" "14" "8" "362" "40.9" "5.10" "60.74" "8" "DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03372, Pf14555" "51567" "ENSG00000111802" "TDP2" "B4DKL8; B4DQ95; O95551; Q2TBE2; Q5JYM0; Q7Z6U5; Q9NUK5; Q9NYY9" "Oxidative damage response" "Nonhomologous End-Joining (NHEJ)" "2" "0" "0.967" "0.950" "0.960" "0.974" "0.960" "0.979" "0.909" "0.948" "1.353" "1153.2" "1114.6" "1095.1" "1106.8" "1122.9" "1106.6" "1128.5" "1048.6" "1093.1" "1559.8" "" "" "" "" "" "" "" "" "" "" "1036.8" "901.9" "990.6" "1080.3" "926.7" "1106.6" "845.0" "926.2" "978.1" "556.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2901873737565675382" "False" "High" "IsMasterProtein" "O95825" "Quinone oxidoreductase-like protein 1 OS=Homo sapiens OX=9606 GN=CRYZL1 PE=1 SV=2" "0.000" "False" "43.001" "31" "9" "14" "9" "349" "38.7" "5.78" "56.18" "9" "other metabolic processes" "" "other molecular function" "" "9946" "ENSG00000205758" "CRYZL1" "B2RDX1; B3KQ77; hsa:9946; O95825; Q96DY0; Q9NVY7" "" "" "0" "0" "1.053" "1.029" "0.991" "1.043" "1.028" "1.021" "1.001" "1.075" "0.849" "1223.3" "1287.6" "1259.4" "1212.1" "1276.2" "1257.0" "1249.1" "1224.0" "1314.8" "1038.3" "" "" "" "" "" "" "" "" "" "" "1099.9" "1041.9" "1139.1" "1183.2" "1053.2" "1257.0" "935.3" "1081.1" "1176.4" "370.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4626223979709161938" "False" "High" "IsMasterProtein" "Q9NXX6" "Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens OX=9606 GN=NSMCE4A PE=1 SV=2" "0.000" "False" "42.947" "25" "10" "15" "10" "385" "44.3" "5.38" "49.82" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf08743, Pf15412" "54780" "ENSG00000107672" "NSMCE4A" "hsa:54780; Q5SQQ5; Q6P673; Q8WY66; Q9BS90; Q9NXX6" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.973" "0.937" "0.878" "0.946" "0.943" "0.926" "0.952" "0.928" "0.813" "1256.1" "1222.1" "1176.9" "1103.4" "1188.3" "1184.9" "1163.7" "1196.0" "1165.2" "1020.8" "" "" "" "" "" "" "" "" "" "" "1129.4" "988.9" "1064.6" "1077.0" "980.6" "1184.9" "871.4" "1056.4" "1042.6" "364.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1505271825198651647" "False" "High" "IsMasterProtein" "P41236" "Protein phosphatase inhibitor 2 OS=Homo sapiens OX=9606 GN=PPP1R2 PE=1 SV=2" "0.000" "False" "42.929" "33" "5" "19" "5" "205" "23.0" "4.74" "83.39" "5" "other metabolic processes;other biological processes" "" "enzyme regulator activity;other molecular function" "Pf04979" "5504" "ENSG00000184203" "PPP1R2" "hsa:5504; P41236" "" "" "0" "0" "0.927" "0.920" "0.938" "0.893" "0.944" "0.922" "0.986" "0.907" "0.791" "1003.9" "931.0" "924.1" "941.4" "896.5" "947.6" "925.7" "990.3" "910.5" "794.6" "" "" "" "" "" "" "" "" "" "" "902.6" "753.3" "835.9" "919.0" "739.8" "947.6" "693.2" "874.7" "814.7" "283.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6447964159336659836" "False" "High" "IsMasterProtein" "Q9UL15" "BAG family molecular chaperone regulator 5 OS=Homo sapiens OX=9606 GN=BAG5 PE=1 SV=1" "0.000" "False" "42.914" "24" "8" "12" "8" "447" "51.2" "6.05" "46.74" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02179" "9529" "ENSG00000166170" "BAG5" "hsa:9529; O94950; Q86W59; Q9UL15" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.989" "1.120" "0.985" "1.067" "1.040" "1.022" "1.039" "1.069" "1.227" "1264.1" "1249.7" "1415.6" "1245.5" "1348.4" "1314.4" "1291.3" "1312.8" "1351.1" "1551.1" "" "" "" "" "" "" "" "" "" "" "1136.5" "1011.2" "1280.5" "1215.8" "1112.8" "1314.4" "966.9" "1159.6" "1209.0" "553.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3208600518816650541" "False" "High" "IsMasterProtein" "Q96IU4" "Putative protein-lysine deacylase ABHD14B OS=Homo sapiens OX=9606 GN=ABHD14B PE=1 SV=1" "0.000" "False" "42.882" "48" "8" "14" "8" "210" "22.3" "6.40" "58.55" "8" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12697" "84836" "ENSG00000114779" "ABHD14B" "hsa:84836; Q86VK8; Q8N8W5; Q96IU4" "" "Cytosolic sulfonation of small molecules" "1" "0" "0.912" "0.976" "1.004" "1.009" "0.975" "0.972" "0.954" "1.008" "0.775" "935.4" "852.9" "913.2" "939.4" "943.6" "912.3" "909.2" "892.2" "943.1" "724.5" "" "" "" "" "" "" "" "" "" "" "841.0" "690.1" "826.1" "917.0" "778.7" "912.3" "680.8" "788.0" "843.8" "258.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980948205033410350" "False" "High" "IsMasterProtein" "Q8WXI9" "Transcriptional repressor p66-beta OS=Homo sapiens OX=9606 GN=GATAD2B PE=1 SV=1" "0.000" "False" "42.804" "17" "10" "15" "9" "593" "65.2" "9.70" "52.33" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00320, Pf16563" "57459" "ENSG00000143614; ENSG00000261992" "GATAD2B" "D3DUZ2; hsa:57459; Q5VUR2; Q7LG68; Q8WXI9; Q9ULS0" "" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "6" "0" "1.074" "1.008" "1.017" "1.047" "1.083" "1.151" "1.026" "0.981" "1.987" "444.0" "476.9" "447.8" "451.7" "465.1" "480.8" "511.0" "455.7" "435.6" "882.4" "" "" "" "" "" "" "" "" "" "" "399.2" "385.9" "405.0" "441.0" "383.8" "480.8" "382.6" "402.5" "389.8" "315.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "144806605175812753" "False" "High" "IsMasterProtein" "Q7L9B9" "Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=EEPD1 PE=1 SV=2" "0.000" "False" "42.801" "20" "9" "12" "9" "569" "62.4" "8.41" "51.62" "9" "DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes" "nucleic acid binding activity" "Pf03372, Pf12836" "80820" "ENSG00000122547" "EEPD1" "hsa:80820; Q7L9B9; Q96K64; Q9C0F7" "" "NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "1" "0" "1.010" "0.929" "1.014" "1.064" "0.952" "1.180" "1.004" "0.920" "0.818" "983.1" "992.8" "913.0" "997.1" "1046.0" "936.1" "1160.0" "986.7" "904.8" "804.6" "" "" "" "" "" "" "" "" "" "" "883.9" "803.3" "825.8" "973.3" "863.2" "936.1" "868.6" "871.6" "809.6" "287.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1398033593130895886" "False" "High" "IsMasterProtein" "O43264" "Centromere/kinetochore protein zw10 homolog OS=Homo sapiens OX=9606 GN=ZW10 PE=1 SV=3" "0.000" "False" "42.792" "17" "11" "15" "11" "779" "88.8" "6.27" "50.81" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf06248, Pf20665, Pf20666" "9183" "ENSG00000086827" "ZW10" "A1A528; hsa:9183; O43264" "" "COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.050" "1.010" "0.959" "1.049" "0.995" "1.074" "1.055" "1.059" "1.474" "1187.8" "1247.3" "1199.2" "1139.6" "1245.5" "1181.6" "1275.6" "1252.7" "1258.0" "1751.0" "" "" "" "" "" "" "" "" "" "" "1067.9" "1009.3" "1084.7" "1112.4" "1027.8" "1181.6" "955.1" "1106.4" "1125.7" "625.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6076185631256904569" "False" "High" "IsMasterProtein" "Q9P016" "Thymocyte nuclear protein 1 OS=Homo sapiens OX=9606 GN=THYN1 PE=1 SV=1" "0.000" "False" "42.766" "50" "12" "22" "12" "225" "25.7" "9.25" "70.70" "12" "" "" "" "Pf01878" "29087" "ENSG00000151500" "THYN1" "hsa:29087; Q567Q2; Q9H3L4; Q9HC20; Q9P016" "" "" "0" "0" "1.109" "0.967" "0.967" "1.101" "1.042" "1.070" "1.080" "1.039" "0.848" "1860.2" "2063.8" "1798.4" "1798.5" "2048.3" "1939.2" "1991.0" "2009.6" "1933.3" "1577.4" "" "" "" "" "" "" "" "" "" "" "1672.5" "1669.9" "1626.7" "1755.6" "1690.3" "1939.2" "1490.8" "1775.0" "1729.9" "563.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1785172786280045072" "False" "High" "IsMasterProtein" "P06730" "Eukaryotic translation initiation factor 4E OS=Homo sapiens OX=9606 GN=EIF4E PE=1 SV=2" "0.000" "False" "42.751" "34" "7" "26" "7" "217" "25.1" "6.15" "85.83" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "1977" "ENSG00000151247" "EIF4E" "B7Z6V1; D6RCQ6; hsa:1977; P06730; Q96E95" "Translation factors; Leptin signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prader-Willi and Angelman syndrome; PI3K-Akt signaling pathway; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Hypertrophy model; Interferon type I signaling pathways" "M-decay: degradation of maternal mRNAs by maternally stored factors; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Deadenylation of mRNA; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; mTORC1-mediated signalling; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "33" "0" "0.958" "0.981" "1.008" "1.006" "0.915" "0.985" "0.981" "0.968" "0.805" "2490.3" "2385.1" "2443.3" "2511.3" "2504.6" "2279.0" "2452.7" "2442.8" "2410.5" "2004.3" "" "" "" "" "" "" "" "" "" "" "2239.1" "1930.0" "2210.0" "2451.4" "2066.8" "2279.0" "1836.5" "2157.6" "2156.9" "715.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5422158606125759469" "False" "High" "IsMasterProtein" "Q86U42" "Polyadenylate-binding protein 2 OS=Homo sapiens OX=9606 GN=PABPN1 PE=1 SV=3" "0.000" "False" "42.722" "30" "8" "25" "8" "306" "32.7" "5.06" "88.77" "8" "RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8106" "ENSG00000100836" "PABPN1" "D3DS49; hsa:8106; O43484; Q86U42" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Inhibition of Host mRNA Processing and RNA Silencing; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "7" "0" "1.024" "0.988" "1.013" "0.988" "0.915" "0.987" "0.986" "0.968" "0.862" "3600.6" "3685.7" "3558.1" "3646.4" "3558.6" "3295.9" "3555.2" "3551.4" "3485.4" "3102.3" "" "" "" "" "" "" "" "" "" "" "3237.3" "2982.4" "3218.4" "3559.4" "2936.6" "3295.9" "2662.1" "3136.8" "3118.7" "1107.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4578961420069997890" "False" "High" "IsMasterProtein" "P31930" "Cytochrome b-c1 complex subunit 1, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC1 PE=1 SV=3" "0.000" "False" "42.712" "33" "12" "16" "11" "480" "52.6" "6.37" "64.89" "12" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00675, Pf05193" "7384" "ENSG00000010256" "UQCRC1" "B2R7R8; hsa:7384; P31930; Q96DD2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "1.018" "1.455" "0.969" "1.063" "1.594" "1.032" "1.043" "1.523" "1.391" "435.2" "443.0" "633.1" "421.7" "462.7" "693.4" "449.3" "454.0" "662.9" "605.5" "" "" "" "" "" "" "" "" "" "" "391.3" "358.5" "572.6" "411.6" "381.8" "693.4" "336.4" "401.0" "593.1" "216.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7556916282893625233" "False" "High" "IsMasterProtein" "O15347" "High mobility group protein B3 OS=Homo sapiens OX=9606 GN=HMGB3 PE=1 SV=4" "0.000" "False" "42.686" "31" "5" "20" "5" "200" "23.0" "8.37" "86.34" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505, Pf09011" "3149" "ENSG00000029993" "HMGB3" "hsa:3149; O15347; O95556; Q6NS40" "" "" "0" "0" "0.875" "0.895" "0.919" "0.930" "0.903" "0.918" "0.934" "0.903" "0.755" "2645.2" "2313.6" "2368.2" "2430.5" "2459.7" "2388.5" "2427.3" "2471.8" "2388.0" "1996.2" "" "" "" "" "" "" "" "" "" "" "2378.3" "1872.1" "2142.2" "2372.5" "2029.8" "2388.5" "1817.5" "2183.3" "2136.8" "712.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4785395366368004219" "False" "High" "IsMasterProtein" "Q15274" "Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Homo sapiens OX=9606 GN=QPRT PE=1 SV=3" "0.000" "False" "42.660" "38" "9" "12" "9" "297" "30.8" "6.21" "46.90" "9" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01729, Pf02749" "23475" "ENSG00000103485" "QPRT" "hsa:23475; Q15274; Q53XW7; Q96G22; Q9BSG6" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome; Kynurenine pathway and links to cell senescence" "Nicotinate metabolism" "5" "0" "1.032" "1.052" "0.981" "1.028" "1.028" "1.033" "1.021" "1.046" "0.794" "892.5" "921.1" "939.0" "875.8" "917.4" "917.5" "921.8" "910.9" "933.9" "708.5" "" "" "" "" "" "" "" "" "" "" "802.4" "745.3" "849.4" "854.9" "757.1" "917.5" "690.2" "804.6" "835.7" "252.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8006254010702621328" "False" "High" "IsMasterProtein" "Cont_P08779" "Keratin, type I cytoskeletal 16 OS=Homo sapiens OX=9606 GN=KRT16 PE=1 SV=4" "0.000" "True" "42.585" "29" "14" "22" "5" "473" "51.2" "5.05" "61.81" "14" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;cytosol;cytoskeleton" "cytoskeletal activity" "Pf00038" "3868" "ENSG00000186832" "KRT16" "A8K488; hsa:3868; P08779; P30654; Q16402; Q9UBG8" "Vitamin D receptor pathway" "Formation of the cornified envelope" "3" "3" "0.155" "0.120" "0.251" "0.132" "0.576" "0.596" "0.206" "0.160" "0.313" "789.9" "122.7" "95.1" "198.1" "104.5" "455.4" "470.6" "163.0" "126.8" "247.4" "" "" "" "" "" "" "" "" "" "" "710.2" "99.3" "86.0" "193.4" "86.2" "455.4" "352.4" "144.0" "113.4" "88.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3574208382527803870" "False" "High" "IsMasterProtein" "Q9Y2X7" "ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2" "0.000" "False" "42.532" "19" "13" "14" "10" "761" "84.3" "6.80" "49.66" "13" "transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf01412, Pf08518, Pf12205, Pf12796, Pf16559" "28964" "ENSG00000108262" "GIT1" "B4DGU9; B4DSV3; hsa:28964; Q86SS0; Q9BRJ4; Q9Y2X7" "CAMKK2 pathway; Regulation of actin cytoskeleton" "RHOJ GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Ephrin signaling; Activation of RAC1 downstream of NMDARs" "12" "0" "1.092" "1.035" "0.956" "1.089" "1.100" "1.158" "1.041" "1.051" "1.321" "1014.0" "1107.7" "1049.5" "968.9" "1104.3" "1115.6" "1174.6" "1055.4" "1065.7" "1339.4" "" "" "" "" "" "" "" "" "" "" "911.7" "896.3" "949.3" "945.8" "911.3" "1115.6" "879.5" "932.2" "953.6" "478.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4563440572163449089" "False" "High" "IsMasterProtein" "P60520" "Gamma-aminobutyric acid receptor-associated protein-like 2 OS=Homo sapiens OX=9606 GN=GABARAPL2 PE=1 SV=1" "0.000" "False" "42.512" "47" "8" "23" "8" "117" "13.7" "8.10" "80.71" "8" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02991" "11345" "ENSG00000034713" "GABARAPL2" "hsa:11345; O08765; P60520; Q6FG91; Q9DCP8; Q9UQF7" "Network map of SARS-CoV-2 signaling pathway; 2q37 copy number variation syndrome; 8q11.23 (RB1CC1) copy number variation" "Macroautophagy; TBC/RABGAPs" "5" "0" "1.046" "1.034" "1.076" "1.007" "1.052" "0.997" "1.042" "1.014" "0.930" "2132.7" "2231.7" "2206.3" "2295.7" "2147.1" "2243.4" "2127.1" "2222.8" "2163.4" "1984.4" "" "" "" "" "" "" "" "" "" "" "1917.5" "1805.8" "1995.6" "2240.9" "1771.8" "2243.4" "1592.7" "1963.3" "1935.8" "708.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7202922108567294127" "False" "High" "IsMasterProtein" "Q8IZP0" "Abl interactor 1 OS=Homo sapiens OX=9606 GN=ABI1 PE=1 SV=4" "0.000" "False" "42.489" "21" "11" "16" "11" "508" "55.0" "7.06" "61.18" "11" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00018, Pf07815" "10006" "ENSG00000136754" "ABI1" "A9Z1Y6; B3KX62; B4DQ58; H7BXI6; hsa:10006; O15147; O76049; O95060; Q5T2R3; Q5T2R4; Q5T2R6; Q5T2R7; Q5T2R9; Q5W070; Q5W072; Q8IZP0; Q8TB63; Q96S81; Q9NXZ9; Q9NYB8" "EGF/EGFR signaling pathway" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; VEGFA-VEGFR2 Pathway" "8" "0" "0.981" "1.021" "1.015" "0.968" "0.986" "0.915" "0.983" "1.045" "0.917" "2012.6" "1975.1" "2054.2" "2043.5" "1948.5" "1985.1" "1841.1" "1978.2" "2103.9" "1845.3" "" "" "" "" "" "" "" "" "" "" "1809.5" "1598.2" "1858.1" "1994.8" "1608.0" "1985.1" "1378.5" "1747.2" "1882.5" "658.7" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7069334460136082352" "False" "High" "IsMasterProtein" "Q9Y4P8" "WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens OX=9606 GN=WIPI2 PE=1 SV=1" "0.000" "False" "42.470" "23" "8" "18" "7" "454" "49.4" "6.46" "65.59" "8" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf21032" "26100" "ENSG00000157954" "WIPI2" "B3KNC2; hsa:26100; Q5MNZ8; Q6FI96; Q75L50; Q96IE4; Q9Y364; Q9Y4P8" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "6" "0" "0.999" "0.954" "0.925" "1.060" "0.905" "0.995" "0.967" "0.973" "1.002" "688.0" "687.1" "656.2" "636.6" "729.3" "622.6" "684.7" "665.3" "669.2" "689.3" "" "" "" "" "" "" "" "" "" "" "618.6" "556.0" "593.5" "621.4" "601.8" "622.6" "512.7" "587.6" "598.8" "246.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2854050072506968056" "False" "High" "IsMasterProtein" "P29372" "DNA-3-methyladenine glycosylase OS=Homo sapiens OX=9606 GN=MPG PE=1 SV=3" "0.000" "False" "42.446" "39" "10" "16" "10" "298" "32.8" "9.57" "60.36" "10" "DNA metabolism;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf02245" "4350" "ENSG00000103152" "MPG" "G5E9E2; hsa:4350; P29372; Q13770; Q15275; Q15961; Q5J9I4; Q96BZ6; Q96S33; Q9NNX5" "Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected purine; Cleavage of the damaged purine; Displacement of DNA glycosylase by APEX1" "5" "0" "1.041" "1.024" "0.914" "1.094" "1.073" "1.052" "0.985" "0.973" "0.916" "1194.1" "1243.4" "1222.9" "1091.7" "1306.4" "1281.7" "1256.6" "1176.3" "1161.5" "1093.4" "" "" "" "" "" "" "" "" "" "" "1073.6" "1006.1" "1106.2" "1065.7" "1078.1" "1281.7" "940.9" "1039.0" "1039.3" "390.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4746768512254432328" "False" "High" "IsMasterProtein" "Q9Y4X5" "E3 ubiquitin-protein ligase ARIH1 OS=Homo sapiens OX=9606 GN=ARIH1 PE=1 SV=2" "0.000" "False" "42.418" "23" "11" "21" "11" "557" "64.1" "5.08" "75.15" "11" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf01485, Pf19422, Pf21235" "25820" "ENSG00000166233" "ARIH1" "B2R6U3; hsa:25820; O76026; Q9H3T6; Q9UEN0; Q9UP39; Q9Y4X5" "" "PKR-mediated signaling; ISG15 antiviral mechanism; RSV-host interactions" "3" "0" "0.974" "0.970" "0.985" "1.031" "0.984" "0.986" "1.037" "1.060" "0.769" "1531.8" "1491.8" "1485.6" "1508.5" "1579.9" "1507.8" "1509.8" "1588.6" "1624.1" "1178.6" "" "" "" "" "" "" "" "" "" "" "1377.3" "1207.1" "1343.8" "1472.5" "1303.8" "1507.8" "1130.5" "1403.2" "1453.3" "420.7" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6490107994498796069" "False" "High" "IsMasterProtein" "Q8WVC0" "RNA polymerase-associated protein LEO1 OS=Homo sapiens OX=9606 GN=LEO1 PE=1 SV=1" "0.000" "False" "42.396" "20" "12" "14" "12" "666" "75.4" "4.51" "47.48" "12" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf04004" "123169" "ENSG00000166477" "LEO1" "hsa:123169; Q8WVC0; Q96N99" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "6" "0" "0.827" "0.802" "0.751" "0.847" "0.846" "0.806" "0.841" "0.845" "1.508" "1492.0" "1233.5" "1196.1" "1120.5" "1264.2" "1262.0" "1202.4" "1254.7" "1260.1" "2250.7" "" "" "" "" "" "" "" "" "" "" "1341.4" "998.1" "1081.9" "1093.7" "1043.2" "1262.0" "900.3" "1108.2" "1127.5" "803.4" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1603503262744250251" "False" "High" "IsMasterProtein" "P62805" "Histone H4 OS=Homo sapiens OX=9606 GN=H4C16 PE=1 SV=2" "0.000" "False" "42.354" "51" "6" "23" "6" "103" "11.4" "11.36" "85.95" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511" "121504; 554313; 8294; 8359; 8360; 8361; 8362; 8363; 8364; 8365; 8366; 8367; 8368; 8370" "ENSG00000158406; ENSG00000197061; ENSG00000197238; ENSG00000197837; ENSG00000270276; ENSG00000270882; ENSG00000273542; ENSG00000274618; ENSG00000275126; ENSG00000276180; ENSG00000276966; ENSG00000277157; ENSG00000278637; ENSG00000278705" "H4C1; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9" "A2VCL0; hsa:121504; hsa:554313; hsa:8294; hsa:8359; hsa:8360; hsa:8361; hsa:8362; hsa:8363; hsa:8364; hsa:8365; hsa:8366; hsa:8367; hsa:8368; hsa:8370; P02304; P02305; P62805; Q6DRA9; Q6FGB8; Q6NWP7" "Gastric cancer network 1; Histone modifications; 22q11.2 copy number variation syndrome; Male infertility; Type II interferon signaling" "HDACs deacetylate histones; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); RNA Polymerase I Promoter Opening; SUMOylation of chromatin organization proteins; Processing of DNA double-strand break ends; HCMV Late Events; Amyloid fiber formation; Meiotic synapsis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RMTs methylate histone arginines; HDMs demethylate histones; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; Nonhomologous End-Joining (NHEJ); Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "52" "0" "0.858" "0.890" "0.928" "0.914" "0.976" "0.813" "0.892" "0.842" "0.837" "2464.8" "2115.4" "2193.2" "2286.8" "2254.0" "2405.6" "2004.5" "2197.8" "2076.2" "2063.7" "" "" "" "" "" "" "" "" "" "" "2216.1" "1711.7" "1983.9" "2232.2" "1860.0" "2405.6" "1501.0" "1941.2" "1857.8" "736.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6258947584785222358" "False" "High" "IsMasterProtein" "P62906" "Large ribosomal subunit protein uL1 OS=Homo sapiens OX=9606 GN=RPL10A PE=1 SV=2" "0.000" "False" "42.347" "42" "9" "15" "9" "217" "24.8" "9.94" "52.43" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00687" "4736" "ENSG00000198755" "RPL10A" "B2R801; hsa:4736; P52859; P53025; P62906; Q5TZT6; Q8J013" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.955" "0.956" "1.091" "1.048" "1.008" "1.014" "1.068" "0.977" "0.717" "1818.5" "1735.9" "1737.6" "1983.4" "1906.4" "1833.2" "1843.1" "1942.3" "1777.1" "1304.5" "" "" "" "" "" "" "" "" "" "" "1635.0" "1404.6" "1571.7" "1936.1" "1573.2" "1833.2" "1380.1" "1715.5" "1590.1" "465.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385363124040609264" "False" "High" "IsMasterProtein" "Q13217" "DnaJ homolog subfamily C member 3 OS=Homo sapiens OX=9606 GN=DNAJC3 PE=1 SV=1" "0.000" "False" "42.339" "27" "13" "13" "13" "504" "57.5" "6.15" "43.23" "13" "protein metabolism;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00226, Pf00515, Pf13181" "5611" "ENSG00000102580" "DNAJC3" "hsa:5611; Q13217; Q86WT9; Q8N4N2" "Photodynamic therapy-induced unfolded protein response" "Neutrophil degranulation; Viral mRNA Translation; PKR-mediated signaling; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; XBP1(S) activates chaperone genes" "7" "0" "1.063" "1.108" "1.025" "1.152" "1.187" "1.067" "1.069" "1.167" "1.144" "882.5" "937.7" "978.1" "904.6" "1016.7" "1047.6" "941.7" "943.4" "1029.9" "1009.1" "" "" "" "" "" "" "" "" "" "" "793.4" "758.8" "884.7" "883.0" "839.0" "1047.6" "705.1" "833.3" "921.6" "360.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4792290450889044309" "False" "High" "IsMasterProtein" "Q96IV0" "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens OX=9606 GN=NGLY1 PE=1 SV=1" "0.000" "False" "42.322" "21" "12" "14" "12" "654" "74.3" "6.89" "49.30" "12" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01841, Pf04721, Pf09409" "55768" "ENSG00000151092" "NGLY1" "B4DJE9; hsa:55768; Q59FB1; Q6PJD8; Q96IV0; Q9BVR8; Q9NR70" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "1.016" "0.903" "0.949" "1.064" "0.964" "1.044" "0.903" "0.999" "1.435" "1212.1" "1232.0" "1094.5" "1150.4" "1289.9" "1168.1" "1265.1" "1094.6" "1211.1" "1739.9" "" "" "" "" "" "" "" "" "" "" "1089.8" "996.9" "990.0" "1122.9" "1064.5" "1168.1" "947.3" "966.9" "1083.6" "621.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-309007205683403427" "False" "High" "IsMasterProtein" "Q8IWS0" "PHD finger protein 6 OS=Homo sapiens OX=9606 GN=PHF6 PE=1 SV=1" "0.000" "False" "42.288" "38" "12" "20" "12" "365" "41.3" "8.68" "60.86" "12" "developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf13771" "84295" "ENSG00000156531" "PHF6" "A8K230; B4E0G4; D3DTG3; E9PC97; hsa:84295; Q5JRC7; Q5JRC8; Q8IWS0; Q96JK3; Q9BRU0" "Mesodermal commitment pathway" "" "1" "0" "0.910" "0.946" "0.871" "0.888" "1.092" "0.874" "0.865" "0.924" "0.780" "1408.8" "1282.0" "1332.8" "1226.6" "1250.5" "1538.3" "1231.2" "1219.3" "1302.0" "1099.4" "" "" "" "" "" "" "" "" "" "" "1266.7" "1037.4" "1205.5" "1197.4" "1031.9" "1538.3" "921.9" "1076.9" "1165.1" "392.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "460406497697363824" "False" "High" "IsMasterProtein" "P61018" "Ras-related protein Rab-4B OS=Homo sapiens OX=9606 GN=RAB4B PE=1 SV=1" "0.000" "False" "42.132" "44" "8" "22" "5" "213" "23.6" "6.06" "68.75" "8" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53916" "ENSG00000167578" "RAB4B" "hsa:53916; P22750; P61018; Q7Z514; Q9HBR6" "Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; RAB geranylgeranylation; MET receptor recycling" "4" "1" "1.116" "1.029" "1.003" "1.144" "1.038" "1.103" "1.083" "1.092" "0.885" "607.8" "678.4" "625.3" "609.8" "695.4" "631.0" "670.3" "658.2" "663.7" "538.0" "" "" "" "" "" "" "" "" "" "" "546.5" "548.9" "565.6" "595.2" "573.8" "631.0" "501.9" "581.4" "593.9" "192.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8640947955125983665" "False" "High" "IsMasterProtein" "Q9Y5A7" "NEDD8 ultimate buster 1 OS=Homo sapiens OX=9606 GN=NUB1 PE=1 SV=2" "0.000" "False" "42.083" "22" "12" "15" "12" "615" "70.5" "5.96" "58.86" "12" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "" "Pf00627, Pf18037" "51667" "ENSG00000013374" "NUB1" "hsa:51667; O95422; Q75MR9; Q8IX22; Q9BXR2; Q9Y5A7" "" "" "0" "0" "1.007" "0.944" "0.989" "1.013" "0.913" "1.041" "0.946" "0.904" "3.580" "1163.8" "1172.2" "1098.4" "1150.6" "1179.2" "1063.1" "1211.6" "1101.0" "1052.3" "4166.1" "" "" "" "" "" "" "" "" "" "" "1046.4" "948.5" "993.5" "1123.1" "973.1" "1063.1" "907.2" "972.5" "941.6" "1487.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1361543221458196950" "False" "High" "IsMasterProtein" "O60547" "GDP-mannose 4,6 dehydratase OS=Homo sapiens OX=9606 GN=GMDS PE=1 SV=1" "0.000" "False" "42.007" "35" "13" "20" "13" "372" "41.9" "7.31" "68.99" "13" "other metabolic processes;signal transduction" "cytosol;other cell component" "other molecular function" "Pf16363" "2762" "ENSG00000112699" "GMDS" "E9PI88; hsa:2762; O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9" "" "GDP-fucose biosynthesis" "1" "0" "1.032" "1.006" "0.985" "1.035" "0.929" "0.979" "0.951" "1.010" "0.806" "1967.2" "2029.7" "1979.0" "1937.7" "2035.9" "1827.9" "1926.1" "1869.8" "1986.6" "1586.0" "" "" "" "" "" "" "" "" "" "" "1768.7" "1642.4" "1790.1" "1891.5" "1680.0" "1827.9" "1442.2" "1651.6" "1777.6" "566.1" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5805697236743296122" "False" "High" "IsMasterProtein" "Q96QU8" "Exportin-6 OS=Homo sapiens OX=9606 GN=XPO6 PE=1 SV=1" "0.000" "False" "41.996" "13" "14" "14" "14" "1125" "128.8" "6.35" "46.05" "14" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03810, Pf08389" "23214" "ENSG00000169180" "XPO6" "A1L3W4; D3DWF9; hsa:23214; Q2YDX3; Q53G88; Q68G50; Q76N88; Q96CP8; Q96QU8; Q9BT21" "" "" "0" "0" "1.048" "1.033" "0.908" "1.055" "0.953" "1.026" "0.988" "0.975" "1.145" "1252.1" "1312.0" "1293.1" "1136.8" "1321.0" "1193.5" "1284.7" "1236.7" "1221.3" "1433.7" "" "" "" "" "" "" "" "" "" "" "1125.8" "1061.6" "1169.7" "1109.6" "1090.1" "1193.5" "962.0" "1092.3" "1092.8" "511.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2341580766278944773" "False" "High" "IsMasterProtein" "P15056" "Serine/threonine-protein kinase B-raf OS=Homo sapiens OX=9606 GN=BRAF PE=1 SV=4" "0.000" "False" "41.907" "19" "13" "14" "13" "766" "84.4" "7.53" "50.70" "13" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00130, Pf02196, Pf07714" "673" "ENSG00000157764" "BRAF" "A4D1T4; B6HY61; B6HY62; B6HY63; B6HY64; B6HY65; B6HY66; hsa:673; P15056; Q13878; Q3MIN6; Q9UDP8; Q9Y6T3" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Alzheimer's disease and miRNA effects; Pilocytic astrocytoma; Glioblastoma signaling pathways; B cell receptor signaling pathway; Corticotropin-releasing hormone signaling pathway; Polycystic kidney disease pathway; Bladder cancer; Focal adhesion; BDNF-TrkB signaling; MAPK signaling pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Endometrial cancer; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Rett syndrome; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Fragile X syndrome; Hepatitis B infection; Melanoma; EGFR tyrosine kinase inhibitor resistance; Regucalcin in proximal tubule epithelial kidney cells; MAPK pathway in congenital thyroid cancer; TCA cycle in senescence; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; ErbB signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Signaling by BRAF and RAF1 fusions; RAF activation; SHOC2 M1731 mutant abolishes MRAS complex function; Gain-of-function MRAS complexes activate RAF signaling; Spry regulation of FGF signaling; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; Signalling to p38 via RIT and RIN; Negative feedback regulation of MAPK pathway" "56" "0" "1.022" "0.995" "1.004" "0.994" "1.017" "0.987" "1.023" "1.031" "0.970" "1215.2" "1242.2" "1209.2" "1219.7" "1208.1" "1235.9" "1199.7" "1243.8" "1253.3" "1179.4" "" "" "" "" "" "" "" "" "" "" "1092.6" "1005.1" "1093.7" "1190.6" "996.9" "1235.9" "898.3" "1098.6" "1121.5" "421.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3716051439609727834" "False" "High" "IsMasterProtein" "Q9NW82" "WD repeat-containing protein 70 OS=Homo sapiens OX=9606 GN=WDR70 PE=1 SV=1" "0.000" "False" "41.893" "21" "11" "15" "11" "654" "73.2" "6.33" "43.89" "11" "" "nucleus;other cell component" "other molecular function" "Pf00400" "55100" "ENSG00000082068" "WDR70" "hsa:55100; Q9H053; Q9NW82" "" "mRNA Splicing - Major Pathway" "1" "0" "1.029" "0.984" "0.990" "1.126" "0.986" "1.116" "1.028" "1.021" "0.995" "583.0" "599.7" "573.4" "576.9" "656.7" "575.1" "650.7" "599.4" "595.4" "579.9" "" "" "" "" "" "" "" "" "" "" "524.2" "485.2" "518.7" "563.1" "541.9" "575.1" "487.2" "529.4" "532.8" "207.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1214418954468839603" "False" "High" "IsMasterProtein" "Q96C01" "Protein FAM136A OS=Homo sapiens OX=9606 GN=FAM136A PE=1 SV=1" "0.000" "False" "41.872" "59" "8" "17" "8" "138" "15.6" "7.61" "63.16" "8" "" "other cell component" "" "Pf05811" "84908" "ENSG00000035141" "FAM136A" "hsa:84908; Q96C01; Q96SS3" "" "" "0" "0" "1.011" "0.980" "0.921" "1.070" "1.064" "1.018" "1.070" "1.048" "0.750" "2212.8" "2237.7" "2168.6" "2037.9" "2367.8" "2354.4" "2253.1" "2367.7" "2319.9" "1659.6" "" "" "" "" "" "" "" "" "" "" "1989.5" "1810.7" "1961.6" "1989.2" "1953.9" "2354.4" "1687.1" "2091.3" "2075.8" "592.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728784246141405942" "False" "High" "IsMasterProtein" "P09543" "2',3'-cyclic-nucleotide 3'-phosphodiesterase OS=Homo sapiens OX=9606 GN=CNP PE=1 SV=2" "0.000" "False" "41.865" "30" "13" "16" "12" "421" "47.5" "9.07" "57.46" "13" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf05881, Pf13671" "1267" "ENSG00000173786" "CNP" "hsa:1267; P09543" "Glial cell differentiation; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Cell lineage map for neuronal differentiation" "" "5" "0" "0.944" "0.985" "0.929" "0.931" "0.976" "0.987" "0.963" "1.024" "0.964" "1423.9" "1344.0" "1403.0" "1323.5" "1325.0" "1389.6" "1405.7" "1371.6" "1458.1" "1373.1" "" "" "" "" "" "" "" "" "" "" "1280.2" "1087.5" "1269.0" "1291.9" "1093.4" "1389.6" "1052.6" "1211.5" "1304.7" "490.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634316393020217319" "False" "High" "IsMasterProtein" "Q5VZE5" "N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA35 PE=1 SV=1" "0.000" "False" "41.839" "18" "11" "14" "11" "725" "83.6" "7.05" "46.26" "11" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04112" "60560" "ENSG00000135040" "NAA35" "hsa:60560; Q5VZE5; Q5VZE6; Q9H631; Q9H703" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.041" "1.156" "1.305" "0.990" "1.095" "0.995" "1.078" "1.166" "0.896" "1241.5" "1292.5" "1435.2" "1620.7" "1228.8" "1360.0" "1235.5" "1338.2" "1447.5" "1112.2" "" "" "" "" "" "" "" "" "" "" "1116.2" "1045.8" "1298.2" "1582.1" "1014.0" "1360.0" "925.1" "1182.0" "1295.2" "397.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7819708601940239359" "False" "High" "IsMasterProtein" "P51946" "Cyclin-H OS=Homo sapiens OX=9606 GN=CCNH PE=1 SV=1" "0.000" "False" "41.836" "33" "9" "12" "9" "323" "37.6" "7.15" "46.97" "9" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity" "Pf00134, Pf16899" "902" "ENSG00000134480" "CCNH" "hsa:902; P51946; Q53X72; Q8TBL9" "Cell cycle; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "39" "0" "0.963" "1.049" "0.913" "1.005" "1.045" "0.937" "0.956" "1.061" "0.948" "586.4" "564.9" "614.9" "535.5" "589.3" "612.9" "549.3" "560.7" "621.9" "556.0" "" "" "" "" "" "" "" "" "" "" "527.2" "457.1" "556.2" "522.7" "486.3" "612.9" "411.3" "495.3" "556.5" "198.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965361047709710571" "False" "High" "IsMasterProtein" "Q58FG1" "Putative heat shock protein HSP 90-alpha A4 OS=Homo sapiens OX=9606 GN=HSP90AA4P PE=5 SV=1" "0.000" "False" "41.822" "14" "6" "101" "2" "418" "47.7" "5.19" "347.39" "6" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00183, Pf13589" "" "" "HSP90AA4P" "Q58FG1" "" "" "0" "0" "0.994" "1.037" "0.929" "1.090" "0.979" "0.962" "0.985" "1.020" "1.012" "842.8" "838.2" "874.1" "782.6" "918.3" "825.2" "811.2" "830.3" "860.0" "852.6" "" "" "" "" "" "" "" "" "" "" "757.8" "678.2" "790.6" "763.9" "757.8" "825.2" "607.4" "733.4" "769.5" "304.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444524107574200916" "False" "High" "IsMasterProtein" "Q9UH73" "Transcription factor COE1 OS=Homo sapiens OX=9606 GN=EBF1 PE=1 SV=2" "0.000" "False" "41.812" "19" "10" "13" "10" "591" "64.4" "8.76" "45.39" "10" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01833, Pf16422, Pf16423" "1879" "ENSG00000164330" "EBF1" "hsa:1879; Q8IW11; Q9UH73" "Adipogenesis; Prion disease pathway; White fat cell differentiation" "Transcriptional regulation of white adipocyte differentiation; Expression and translocation of olfactory receptors" "5" "0" "1.013" "0.893" "0.958" "1.055" "0.916" "1.054" "1.038" "0.875" "1.232" "1011.3" "1024.7" "903.0" "968.6" "1067.2" "925.9" "1065.7" "1050.2" "884.7" "1246.2" "" "" "" "" "" "" "" "" "" "" "909.2" "829.1" "816.8" "945.5" "880.7" "925.9" "797.9" "927.6" "791.7" "444.9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2205363031532401399" "False" "High" "IsMasterProtein" "Q16763" "Ubiquitin-conjugating enzyme E2 S OS=Homo sapiens OX=9606 GN=UBE2S PE=1 SV=2" "0.000" "False" "41.799" "42" "8" "14" "8" "222" "23.8" "8.38" "62.82" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "27338" "ENSG00000108106" "UBE2S" "hsa:27338; Q16763; Q9BTC1" "" "Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "19" "0" "1.001" "1.171" "0.987" "1.069" "1.183" "1.041" "1.046" "1.290" "0.886" "1366.3" "1367.5" "1600.2" "1348.6" "1460.8" "1616.5" "1422.4" "1429.2" "1762.8" "1210.1" "" "" "" "" "" "" "" "" "" "" "1228.5" "1106.6" "1447.5" "1316.4" "1205.5" "1616.5" "1065.1" "1262.4" "1577.3" "432.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6149624510723031081" "False" "High" "IsMasterProtein" "P30043" "Flavin reductase (NADPH) OS=Homo sapiens OX=9606 GN=BLVRB PE=1 SV=3" "0.000" "False" "41.783" "34" "5" "20" "5" "206" "22.1" "7.65" "84.73" "5" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13460" "645" "ENSG00000090013" "BLVRB" "A6NKD8; B2R5C6; hsa:645; P30043; P32078; P53005; Q32LZ2" "Nuclear receptors meta-pathway; NRF2 pathway; IL-10 anti-inflammatory signaling pathway" "Cytoprotection by HMOX1; Heme degradation" "5" "0" "1.024" "0.986" "0.976" "1.019" "1.011" "1.031" "0.989" "0.984" "0.867" "672.7" "689.1" "663.3" "656.8" "685.5" "680.0" "693.5" "665.6" "662.3" "583.4" "" "" "" "" "" "" "" "" "" "" "604.9" "557.6" "600.0" "641.1" "565.7" "680.0" "519.2" "587.9" "592.6" "208.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7361850666082059512" "False" "High" "IsMasterProtein" "P54252" "Ataxin-3 OS=Homo sapiens OX=9606 GN=ATXN3 PE=1 SV=5" "0.000" "False" "41.744" "25" "7" "13" "7" "361" "41.2" "4.78" "55.96" "7" "cell-cell signaling;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02099, Pf02809, Pf16619" "4287" "ENSG00000066427" "ATXN3" "A7LFZ5; D6RDL9; E9PB63; hsa:4287; O15284; O15285; O15286; P54252; Q8N189; Q96TC3; Q96TC4; Q9H3N0" "HDAC6 interactions in the central nervous system" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Josephin domain DUBs" "3" "0" "1.078" "0.975" "0.983" "1.163" "1.069" "1.102" "1.075" "0.985" "1.373" "602.8" "649.9" "587.7" "592.6" "700.9" "644.3" "664.5" "648.1" "593.5" "827.5" "" "" "" "" "" "" "" "" "" "" "541.9" "525.9" "531.6" "578.4" "578.4" "644.3" "497.6" "572.4" "531.1" "295.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8106811875095759613" "False" "High" "IsMasterProtein" "P06454" "Prothymosin alpha OS=Homo sapiens OX=9606 GN=PTMA PE=1 SV=2" "0.000" "False" "41.566" "23" "5" "56" "5" "111" "12.2" "3.78" "222.48" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf03247" "5757" "ENSG00000187514" "PTMA" "hsa:5757; P06454; Q15249; Q15592" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.960" "0.963" "1.223" "0.919" "0.877" "0.941" "0.988" "0.900" "0.960" "6546.1" "6281.8" "6304.0" "8005.7" "6014.7" "5738.7" "6158.7" "6468.5" "5891.8" "6281.8" "" "" "" "" "" "" "" "" "" "" "5885.6" "5083.0" "5702.2" "7814.6" "4963.5" "5738.7" "4611.5" "5713.4" "5271.9" "2242.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2950951748836187489" "False" "High" "IsMasterProtein" "Q96MG7" "Non-structural maintenance of chromosomes element 3 homolog OS=Homo sapiens OX=9606 GN=NSMCE3 PE=1 SV=1" "0.000" "False" "41.562" "46" "13" "16" "13" "304" "34.3" "9.28" "43.75" "13" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01454" "56160" "ENSG00000185115; ENSG00000282130" "NSMCE3" "hsa:56160; Q8IW16; Q8TEI6; Q96MG7; Q9H214" "15q11q13 copy number variation" "SUMOylation of DNA damage response and repair proteins" "2" "0" "0.969" "0.936" "0.943" "1.022" "1.024" "0.963" "1.007" "0.981" "0.874" "993.0" "962.1" "929.0" "936.6" "1014.5" "1016.5" "956.4" "1000.0" "974.6" "867.9" "" "" "" "" "" "" "" "" "" "" "892.8" "778.5" "840.3" "914.3" "837.2" "1016.5" "716.1" "883.2" "872.0" "309.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3054532643706144768" "False" "High" "IsMasterProtein" "Q9H0W9" "Ester hydrolase C11orf54 OS=Homo sapiens OX=9606 GN=C11orf54 PE=1 SV=1" "0.000" "False" "41.560" "33" "8" "15" "8" "315" "35.1" "6.70" "58.15" "8" "" "nucleus" "other molecular function" "Pf08925" "28970" "ENSG00000182919" "C11orf54" "A8K850; hsa:28970; Q6FI88; Q6XYB0; Q96EI3; Q96IX1; Q9H0W9; Q9Y6B4" "" "" "0" "0" "0.976" "0.959" "1.006" "1.078" "0.967" "1.030" "0.981" "0.955" "0.848" "1499.5" "1463.4" "1438.6" "1508.7" "1617.0" "1450.0" "1544.3" "1471.5" "1432.5" "1271.2" "" "" "" "" "" "" "" "" "" "" "1348.2" "1184.1" "1301.2" "1472.7" "1334.4" "1450.0" "1156.3" "1299.7" "1281.8" "453.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4877506006391296740" "False" "High" "IsMasterProtein" "P28072" "Proteasome subunit beta type-6 OS=Homo sapiens OX=9606 GN=PSMB6 PE=1 SV=4" "0.000" "False" "41.550" "35" "7" "26" "7" "239" "25.3" "4.92" "92.21" "7" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00227" "5694" "ENSG00000142507" "PSMB6" "hsa:5694; P28072; Q96J55" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.032" "1.002" "0.979" "1.012" "0.995" "1.046" "0.983" "1.001" "0.912" "1601.4" "1653.3" "1603.9" "1567.8" "1620.6" "1592.9" "1675.0" "1573.6" "1603.2" "1461.2" "" "" "" "" "" "" "" "" "" "" "1439.8" "1337.8" "1450.8" "1530.4" "1337.3" "1592.9" "1254.2" "1389.9" "1434.5" "521.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3338073365584811594" "False" "High" "IsMasterProtein" "P83731" "Large ribosomal subunit protein eL24 OS=Homo sapiens OX=9606 GN=RPL24 PE=1 SV=1" "0.000" "False" "41.525" "36" "7" "16" "7" "157" "17.8" "11.25" "56.04" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01246" "6152" "ENSG00000114391" "RPL24" "B2R4Y3; hsa:6152; P38663; P83731; Q6IBS3" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.940" "0.895" "0.923" "0.856" "0.960" "0.917" "0.903" "1.010" "1.012" "1989.6" "1869.3" "1781.2" "1837.3" "1704.0" "1909.6" "1824.1" "1796.2" "2008.7" "2013.6" "" "" "" "" "" "" "" "" "" "" "1788.8" "1512.5" "1611.2" "1793.4" "1406.2" "1909.6" "1365.8" "1586.6" "1797.4" "718.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8205136122998856932" "False" "High" "IsMasterProtein" "P60981" "Destrin OS=Homo sapiens OX=9606 GN=DSTN PE=1 SV=3" "0.000" "False" "41.497" "48" "8" "23" "6" "165" "18.5" "7.85" "69.76" "8" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00241" "11034" "ENSG00000125868" "DSTN" "B2R6N2; B4DYA6; hsa:11034; P18282; P60981; Q5W166; Q6IAW2" "Androgen receptor signaling pathway" "" "1" "0" "1.000" "0.964" "0.966" "0.984" "0.941" "0.933" "1.008" "1.012" "0.765" "1156.3" "1155.9" "1114.1" "1117.2" "1138.0" "1088.4" "1078.7" "1165.6" "1170.1" "885.0" "" "" "" "" "" "" "" "" "" "" "1039.6" "935.3" "1007.7" "1090.6" "939.1" "1088.4" "807.7" "1029.6" "1047.0" "315.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1416539979039474058" "False" "High" "IsMasterProtein" "Q99426" "Tubulin-folding cofactor B OS=Homo sapiens OX=9606 GN=TBCB PE=1 SV=2" "0.000" "False" "41.464" "38" "10" "21" "10" "244" "27.3" "5.15" "74.21" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14560" "1155" "ENSG00000105254" "TBCB" "hsa:1155; O00111; O00674; O14728; Q6FGY5; Q99426" "" "Post-chaperonin tubulin folding pathway" "1" "0" "0.989" "1.018" "1.038" "1.015" "0.980" "1.019" "1.056" "0.976" "1.026" "3479.7" "3441.0" "3542.1" "3611.2" "3531.2" "3411.8" "3544.8" "3675.0" "3396.5" "3570.8" "" "" "" "" "" "" "" "" "" "" "3128.6" "2784.3" "3203.9" "3525.0" "2914.0" "3411.8" "2654.3" "3246.0" "3039.2" "1274.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5053375512568543969" "False" "High" "IsMasterProtein" "Q0VDF9" "Heat shock 70 kDa protein 14 OS=Homo sapiens OX=9606 GN=HSPA14 PE=1 SV=1" "0.000" "False" "41.447" "25" "12" "15" "12" "509" "54.8" "5.59" "49.83" "12" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00012" "51182" "ENSG00000187522" "HSPA14" "A8K8F8; B0YIY9; hsa:51182; Q0VDF9; Q9P0X2; Q9UI07" "Parkin-ubiquitin proteasomal system pathway" "Regulation of HSF1-mediated heat shock response" "2" "0" "1.030" "1.031" "0.992" "0.972" "1.062" "0.980" "0.918" "1.093" "4.116" "1041.4" "1073.1" "1073.7" "1033.4" "1012.8" "1105.9" "1020.8" "956.4" "1138.2" "4286.9" "" "" "" "" "" "" "" "" "" "" "936.4" "868.3" "971.2" "1008.8" "835.8" "1105.9" "764.4" "844.8" "1018.5" "1530.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3899808669823360054" "False" "High" "IsMasterProtein" "Q9Y2U8" "Inner nuclear membrane protein Man1 OS=Homo sapiens OX=9606 GN=LEMD3 PE=1 SV=2" "0.000" "False" "41.428" "18" "8" "9" "8" "911" "99.9" "7.55" "46.50" "8" "other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf03020, Pf09402" "23592" "ENSG00000174106" "LEMD3" "hsa:23592; Q9NT47; Q9NYA5; Q9Y2U8" "Envelope proteins and their potential roles in EDMD physiopathology" "RND2 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "0.926" "0.880" "0.823" "0.967" "1.004" "0.919" "0.927" "0.902" "0.946" "309.1" "286.2" "272.1" "254.3" "298.8" "310.3" "284.0" "286.6" "278.8" "292.5" "" "" "" "" "" "" "" "" "" "" "277.9" "231.6" "246.1" "248.2" "246.6" "310.3" "212.6" "253.1" "249.5" "104.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194436757358923865" "False" "High" "IsMasterProtein" "Q5W0V3" "FHF complex subunit HOOK interacting protein 2A OS=Homo sapiens OX=9606 GN=FHIP2A PE=1 SV=1" "0.000" "False" "41.350" "17" "11" "16" "11" "765" "86.5" "5.29" "51.24" "11" "" "" "" "Pf10257, Pf19311, Pf19314" "57700" "ENSG00000151553" "FHIP2A" "Q5H9P7; Q5W0V2; Q5W0V3; Q8IY76; Q9HCH2" "" "" "0" "0" "0.989" "0.988" "0.954" "1.031" "1.017" "1.032" "1.001" "1.000" "0.969" "714.2" "706.7" "706.0" "681.4" "736.0" "726.5" "737.1" "715.0" "714.2" "692.3" "" "" "" "" "" "" "" "" "" "" "642.1" "571.8" "638.6" "665.2" "607.4" "726.5" "551.9" "631.6" "639.1" "247.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9200930033631648957" "False" "High" "IsMasterProtein" "Q06413" "Myocyte-specific enhancer factor 2C OS=Homo sapiens OX=9606 GN=MEF2C PE=1 SV=1" "0.000" "False" "41.327" "19" "8" "17" "6" "473" "51.2" "8.03" "58.37" "8" "cell-cell signaling;cell cycle OR cell proliferation;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4208" "ENSG00000081189" "MEF2C" "C9JMZ0; D7F7N5; F8W7V7; hsa:4208; Q06413" "Energy metabolism; Heart development; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Prion disease pathway; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Endochondral ossification; Endochondral ossification with skeletal dysplasias; GDNF signaling; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "ERK/MAPK targets; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis; Cardiogenesis; MECP2 regulates transcription factors" "30" "3" "0.992" "0.943" "1.015" "1.003" "0.906" "1.003" "1.007" "0.935" "1.051" "1033.1" "1024.7" "974.2" "1049.1" "1036.4" "935.5" "1036.5" "1039.9" "966.5" "1085.5" "" "" "" "" "" "" "" "" "" "" "928.9" "829.1" "881.2" "1024.1" "855.2" "935.5" "776.1" "918.5" "864.8" "387.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1595519607435168922" "False" "High" "IsMasterProtein" "P31942" "Heterogeneous nuclear ribonucleoprotein H3 OS=Homo sapiens OX=9606 GN=HNRNPH3 PE=1 SV=2" "0.000" "False" "41.314" "26" "7" "12" "6" "346" "36.9" "6.87" "47.48" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "3189" "ENSG00000096746" "HNRNPH3" "A8K682; B3KRE1; hsa:3189; P31942; Q9BSX1; Q9NP53; Q9NP96; Q9NPA7; Q9NPI4; Q9UFU4; Q9Y4J5" "" "" "0" "0" "0.953" "0.902" "1.038" "1.052" "0.908" "0.986" "0.874" "0.919" "6.576" "624.5" "594.9" "563.5" "648.3" "657.3" "566.9" "615.8" "545.6" "573.7" "4107.1" "" "" "" "" "" "" "" "" "" "" "561.5" "481.4" "509.7" "632.8" "542.4" "566.9" "461.1" "481.9" "513.3" "1466.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7014036665860809700" "False" "High" "IsMasterProtein" "Q13459" "Unconventional myosin-IXb OS=Homo sapiens OX=9606 GN=MYO9B PE=1 SV=3" "0.000" "False" "41.279" "7" "12" "12" "12" "2157" "243.2" "8.75" "44.47" "12" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf00620, Pf00788" "4650" "ENSG00000099331" "MYO9B" "hsa:4650; O75314; Q13459; Q9NUJ2; Q9UHN0" "Vitamin D receptor pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHOF GTPase cycle; SLIT2:ROBO1 increases RHOA activity" "10" "0" "1.045" "1.027" "1.039" "1.096" "1.041" "1.118" "1.062" "1.065" "1.786" "676.2" "706.5" "694.8" "702.4" "741.3" "704.1" "755.8" "718.2" "720.4" "1207.9" "" "" "" "" "" "" "" "" "" "" "608.0" "571.7" "628.4" "685.6" "611.8" "704.1" "565.9" "634.3" "644.6" "431.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3710113209643881705" "False" "High" "IsMasterProtein" "O75794" "Translation initiation factor eIF2 assembly protein OS=Homo sapiens OX=9606 GN=CDC123 PE=1 SV=1" "0.000" "False" "41.267" "29" "9" "16" "9" "336" "39.1" "4.81" "55.27" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "" "Pf07065" "8872" "ENSG00000151465" "CDC123" "A8JZZ7; hsa:8872; O75794; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9" "" "" "0" "0" "1.056" "1.068" "0.992" "1.067" "1.053" "1.079" "1.021" "1.097" "1.128" "1486.1" "1569.8" "1586.5" "1473.9" "1585.7" "1565.5" "1602.8" "1517.6" "1631.0" "1676.6" "" "" "" "" "" "" "" "" "" "" "1336.2" "1270.2" "1435.1" "1438.7" "1308.5" "1565.5" "1200.2" "1340.5" "1459.4" "598.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6175620915795625691" "False" "High" "IsMasterProtein" "Q13151" "Heterogeneous nuclear ribonucleoprotein A0 OS=Homo sapiens OX=9606 GN=HNRNPA0 PE=1 SV=1" "0.000" "False" "41.254" "26" "7" "40" "5" "305" "30.8" "9.29" "117.73" "7" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10949" "ENSG00000177733" "HNRNPA0" "hsa:10949; Q13151; Q6IB18" "" "" "0" "0" "0.943" "0.939" "1.041" "1.029" "0.916" "1.048" "0.984" "1.008" "2.990" "791.9" "746.4" "743.3" "824.1" "814.5" "725.3" "829.7" "779.6" "798.3" "2367.7" "" "" "" "" "" "" "" "" "" "" "712.0" "604.0" "672.4" "804.5" "672.1" "725.3" "621.2" "688.6" "714.3" "845.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1789067979643489698" "False" "High" "IsMasterProtein" "P46976" "Glycogenin-1 OS=Homo sapiens OX=9606 GN=GYG1 PE=1 SV=4" "0.000" "False" "41.246" "19" "6" "16" "6" "350" "39.4" "5.53" "58.51" "6" "other metabolic processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01501" "2992" "ENSG00000163754" "GYG1" "D3DNH0; D3DNH1; D3DNH2; hsa:2992; P46976; Q6FHZ1; Q9UNV0" "Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen synthesis; Glycogen breakdown (glycogenolysis); Myoclonic epilepsy of Lafora; Glycogen storage disease type II (GAA); Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "10" "0" "0.915" "0.851" "1.001" "0.893" "0.880" "0.967" "0.925" "0.900" "0.813" "999.5" "914.1" "850.8" "1000.0" "892.9" "879.2" "966.4" "925.0" "899.9" "812.2" "" "" "" "" "" "" "" "" "" "" "898.6" "739.6" "769.5" "976.2" "736.8" "879.2" "723.7" "817.0" "805.2" "289.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4783590985173723979" "False" "High" "IsMasterProtein" "Q96CN7" "Isochorismatase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ISOC1 PE=1 SV=3" "0.000" "False" "41.194" "24" "6" "14" "6" "298" "32.2" "7.39" "49.46" "6" "" "other cytoplasmic organelle;other cell component" "" "Pf00857" "51015" "ENSG00000066583" "ISOC1" "hsa:51015; Q7Z770; Q96CN7" "" "" "0" "0" "1.023" "0.998" "1.005" "1.012" "1.027" "0.997" "1.019" "1.082" "0.875" "846.3" "865.6" "845.0" "850.7" "856.6" "869.2" "843.7" "862.0" "915.6" "740.6" "" "" "" "" "" "" "" "" "" "" "760.9" "700.4" "764.3" "830.4" "706.9" "869.2" "631.7" "761.4" "819.3" "264.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7478524853152137733" "False" "High" "IsMasterProtein" "P43487" "Ran-specific GTPase-activating protein OS=Homo sapiens OX=9606 GN=RANBP1 PE=1 SV=1" "0.000" "False" "41.191" "39" "7" "26" "7" "201" "23.3" "5.29" "96.81" "7" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00638" "5902" "ENSG00000099901" "RANBP1" "hsa:5902; P43487; Q53EY3" "22q11.2 copy number variation syndrome" "Rev-mediated nuclear export of HIV RNA" "2" "0" "0.995" "0.977" "0.936" "0.979" "1.057" "0.938" "1.011" "0.937" "0.903" "3536.9" "3518.0" "3455.9" "3310.7" "3462.6" "3736.8" "3317.3" "3576.4" "3315.4" "3194.5" "" "" "" "" "" "" "" "" "" "" "3180.0" "2846.6" "3126.0" "3231.7" "2857.4" "3736.8" "2483.9" "3158.9" "2966.6" "1140.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6273876737902892662" "False" "High" "IsMasterProtein" "P83876" "Thioredoxin-like protein 4A OS=Homo sapiens OX=9606 GN=TXNL4A PE=1 SV=1" "0.000" "False" "41.180" "44" "6" "22" "6" "142" "16.8" "5.85" "63.12" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf02966" "10907" "ENSG00000141759" "TXNL4A" "B2RC18; hsa:10907; O14834; P83876" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.038" "1.025" "0.983" "1.066" "0.967" "1.012" "1.026" "1.051" "0.756" "2005.2" "2081.7" "2055.3" "1970.7" "2137.3" "1938.5" "2028.4" "2058.3" "2107.3" "1516.2" "" "" "" "" "" "" "" "" "" "" "1802.9" "1684.5" "1859.0" "1923.7" "1763.8" "1938.5" "1518.8" "1818.0" "1885.6" "541.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1756983135160374971" "False" "High" "IsMasterProtein" "Q8NBJ5" "Procollagen galactosyltransferase 1 OS=Homo sapiens OX=9606 GN=COLGALT1 PE=1 SV=1" "0.000" "False" "41.159" "18" "12" "16" "12" "622" "71.6" "7.31" "54.44" "12" "cell organization and biogenesis;other biological processes" "ER/Golgi" "other molecular function" "Pf01755, Pf13704" "79709" "ENSG00000130309" "COLGALT1" "hsa:79709; Q8NBJ5; Q8NC64" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "0.987" "1.030" "1.036" "1.045" "1.038" "1.085" "0.973" "1.034" "1.249" "1048.1" "1034.6" "1079.5" "1085.5" "1095.3" "1087.8" "1137.7" "1020.2" "1084.2" "1308.6" "" "" "" "" "" "" "" "" "" "" "942.4" "837.2" "976.4" "1059.6" "903.9" "1087.8" "851.9" "901.1" "970.1" "467.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3343567279109484109" "False" "High" "IsMasterProtein" "P61326" "Protein mago nashi homolog OS=Homo sapiens OX=9606 GN=MAGOH PE=1 SV=1" "0.000" "False" "41.150" "48" "10" "20" "10" "146" "17.2" "6.11" "68.82" "10" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus" "" "Pf02792" "4116" "ENSG00000162385" "MAGOH" "B1ARP8; B2R5A2; hsa:4116; O35169; P50606; P61326; Q5SW69" "TAR syndrome" "mRNA Splicing - Major Pathway; Regulation of expression of SLITs and ROBOs; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "7" "0" "0.985" "0.993" "1.023" "1.012" "0.929" "0.953" "1.013" "1.007" "0.835" "2841.5" "2799.8" "2820.6" "2907.2" "2876.0" "2640.6" "2707.4" "2877.5" "2861.6" "2371.5" "" "" "" "" "" "" "" "" "" "" "2554.8" "2265.5" "2551.3" "2837.8" "2373.3" "2640.6" "2027.3" "2541.6" "2560.6" "846.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910881260683280979" "False" "High" "IsMasterProtein" "Q9UEE9" "Craniofacial development protein 1 OS=Homo sapiens OX=9606 GN=CFDP1 PE=1 SV=1" "0.000" "False" "41.099" "35" "10" "17" "10" "299" "33.6" "4.81" "68.39" "10" "cell adhesion;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07572" "10428" "ENSG00000153774" "CFDP1" "hsa:10428; O00393; O00404; Q9UEE9; Q9UEF0; Q9UEF1; Q9UEF8" "" "" "0" "0" "0.896" "0.897" "0.950" "0.951" "0.895" "0.957" "0.967" "0.903" "0.739" "1861.1" "1667.7" "1670.3" "1767.3" "1769.1" "1666.4" "1780.4" "1800.0" "1680.8" "1376.1" "" "" "" "" "" "" "" "" "" "" "1673.3" "1349.4" "1510.9" "1725.1" "1459.9" "1666.4" "1333.1" "1589.9" "1504.0" "491.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412220755654312839" "False" "High" "IsMasterProtein" "Q15652" "Probable JmjC domain-containing histone demethylation protein 2C OS=Homo sapiens OX=9606 GN=JMJD1C PE=1 SV=2" "0.000" "False" "41.094" "5" "14" "16" "13" "2540" "284.3" "7.87" "50.99" "14" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "221037" "ENSG00000171988" "JMJD1C" "A0T124; hsa:221037; Q15652; Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7" "Pathways affected in adenoid cystic carcinoma" "Factors involved in megakaryocyte development and platelet production" "2" "0" "0.963" "0.934" "0.941" "0.959" "0.927" "1.028" "0.980" "0.900" "0.980" "1088.0" "1048.2" "1016.0" "1024.0" "1043.2" "1008.9" "1118.8" "1066.1" "979.6" "1066.1" "" "" "" "" "" "" "" "" "" "" "978.3" "848.2" "919.0" "999.6" "860.9" "1008.9" "837.7" "941.7" "876.5" "380.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3035595102958398127" "False" "High" "IsMasterProtein" "P46777" "Large ribosomal subunit protein uL18 OS=Homo sapiens OX=9606 GN=RPL5 PE=1 SV=3" "0.000" "False" "41.089" "32" "10" "18" "10" "297" "34.3" "9.72" "56.07" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf14204, Pf17144" "6125" "ENSG00000122406" "RPL5" "hsa:6125; P46777; Q32LZ3; Q53HH6; Q9H3F4" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.980" "0.859" "1.029" "1.073" "0.955" "0.965" "1.043" "0.887" "0.759" "1097.5" "1076.1" "942.9" "1129.3" "1177.3" "1047.6" "1059.5" "1144.1" "973.6" "833.0" "" "" "" "" "" "" "" "" "" "" "986.7" "870.7" "852.9" "1102.3" "971.5" "1047.6" "793.3" "1010.6" "871.1" "297.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5091177938667012153" "False" "High" "IsMasterProtein" "P41743" "Protein kinase C iota type OS=Homo sapiens OX=9606 GN=PRKCI PE=1 SV=2" "0.000" "False" "41.042" "22" "9" "13" "9" "596" "68.2" "5.85" "53.62" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00433, Pf00564" "5584" "ENSG00000163558" "PRKCI" "D3DNQ4; hsa:5584; P41743; Q8WW06" "Glioblastoma signaling pathways; Corticotropin-releasing hormone signaling pathway; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Osteoblast differentiation and related diseases; Insulin signaling; Complement system in neuronal development and plasticity; Chronic hyperglycemia impairment of neuron function" "KEAP1-NFE2L2 pathway; Tight junction interactions; Pre-NOTCH Transcription and Translation; p75NTR recruits signalling complexes" "15" "0" "1.089" "1.217" "1.024" "1.085" "1.165" "1.055" "1.031" "1.194" "1.182" "975.9" "1063.0" "1187.2" "999.6" "1058.6" "1136.7" "1029.9" "1005.6" "1165.3" "1153.2" "" "" "" "" "" "" "" "" "" "" "877.4" "860.2" "1073.9" "975.8" "873.5" "1136.7" "771.1" "888.2" "1042.7" "411.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3690320084066520669" "False" "High" "IsMasterProtein" "Cont_P04259" "Keratin, type II cytoskeletal 6B OS=Homo sapiens OX=9606 GN=KRT6B PE=1 SV=5" "0.000" "True" "41.040" "20" "14" "17" "1" "564" "60.0" "8.00" "54.15" "14" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3854" "ENSG00000185479" "KRT6B" "hsa:3854; P04259; P48669" "" "Formation of the cornified envelope" "2" "0" "0.156" "0.141" "0.194" "0.170" "0.259" "0.214" "0.154" "0.158" "0.247" "867.4" "135.1" "122.7" "168.3" "147.3" "224.6" "186.0" "133.7" "136.9" "214.4" "" "" "" "" "" "" "" "" "" "" "779.8" "109.3" "110.9" "164.3" "121.5" "224.6" "139.3" "118.1" "122.5" "76.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6816418598839755867" "False" "High" "IsMasterProtein" "Q9NXC5" "GATOR2 complex protein MIOS OS=Homo sapiens OX=9606 GN=MIOS PE=1 SV=2" "0.000" "False" "41.017" "17" "12" "14" "12" "875" "98.5" "6.73" "40.58" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17034, Pf21719, Pf21720" "54468" "ENSG00000164654" "MIOS" "B2RTV6; hsa:54468; O75216; Q7L551; Q9H092; Q9NXC5" "" "Amino acids regulate mTORC1" "1" "0" "1.026" "1.107" "0.979" "1.060" "1.174" "1.070" "1.049" "1.091" "0.795" "278.6" "285.9" "308.4" "272.8" "295.4" "327.1" "298.0" "292.3" "304.1" "221.5" "" "" "" "" "" "" "" "" "" "" "250.5" "231.4" "278.9" "266.3" "243.8" "327.1" "223.1" "258.2" "272.1" "79.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3537193466780696360" "False" "High" "IsMasterProtein" "P30047" "GTP cyclohydrolase 1 feedback regulatory protein OS=Homo sapiens OX=9606 GN=GCHFR PE=1 SV=3" "0.000" "False" "40.998" "58" "3" "16" "3" "84" "9.7" "6.54" "78.29" "3" "other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf06399" "2644" "ENSG00000137880" "GCHFR" "B2R4L6; B7ZLM8; hsa:2644; P30047; Q2M1Q2; Q99749" "" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "1" "0" "0.957" "1.008" "1.014" "1.133" "1.028" "1.108" "1.024" "0.997" "0.815" "1062.0" "1016.8" "1070.2" "1076.6" "1203.8" "1091.6" "1176.6" "1087.8" "1058.8" "866.0" "" "" "" "" "" "" "" "" "" "" "954.9" "822.7" "968.0" "1050.9" "993.4" "1091.6" "881.0" "960.8" "947.4" "309.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3538094465215650253" "False" "High" "IsMasterProtein" "Q8N4J0" "Carnosine N-methyltransferase OS=Homo sapiens OX=9606 GN=CARNMT1 PE=1 SV=1" "0.000" "False" "40.993" "31" "11" "13" "11" "409" "47.2" "6.32" "46.27" "11" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf07942" "138199" "ENSG00000156017" "CARNMT1" "hsa:138199; Q7Z383; Q8N4J0; Q8N7C5" "" "Histidine catabolism" "1" "0" "1.064" "0.942" "0.992" "1.012" "1.010" "1.073" "1.006" "0.995" "0.696" "269.8" "287.1" "254.1" "267.8" "273.2" "272.6" "289.4" "271.4" "268.5" "187.9" "" "" "" "" "" "" "" "" "" "" "242.6" "232.3" "229.8" "261.4" "225.4" "272.6" "216.7" "239.7" "240.2" "67.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6388610480367959150" "False" "High" "IsMasterProtein" "O15446" "DNA-directed RNA polymerase I subunit RPA34 OS=Homo sapiens OX=9606 GN=POLR1G PE=1 SV=1" "0.000" "False" "40.959" "25" "8" "12" "8" "510" "55.0" "8.51" "54.78" "8" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf08208" "10849" "ENSG00000117877" "POLR1G" "hsa:10849; O15446; Q32N11; Q7Z5U2; Q9UPF6" "2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "6" "0" "0.994" "1.064" "1.031" "1.060" "1.125" "1.001" "1.080" "1.084" "1.484" "840.9" "836.2" "894.8" "867.1" "891.7" "946.1" "842.0" "907.9" "911.7" "1247.9" "" "" "" "" "" "" "" "" "" "" "756.1" "676.7" "809.4" "846.4" "735.8" "946.1" "630.5" "801.9" "815.8" "445.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7165899401853608207" "False" "High" "IsMasterProtein" "P04424" "Argininosuccinate lyase OS=Homo sapiens OX=9606 GN=ASL PE=1 SV=4" "0.000" "False" "40.957" "27" "10" "12" "10" "464" "51.6" "6.48" "41.88" "10" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00206, Pf14698" "435" "ENSG00000126522" "ASL" "E7EMI0; E9PE48; hsa:435; P04424; Q6LDS5; Q96HS2" "Alanine and aspartate metabolism" "Urea cycle" "2" "0" "0.994" "1.008" "0.965" "1.001" "0.988" "1.006" "0.978" "0.981" "0.756" "819.0" "814.0" "825.3" "790.3" "820.2" "808.8" "823.6" "800.8" "803.7" "619.4" "" "" "" "" "" "" "" "" "" "" "736.3" "658.7" "746.5" "771.5" "676.8" "808.8" "616.7" "707.3" "719.2" "221.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "274876564336853802" "False" "High" "IsMasterProtein" "Q01804" "OTU domain-containing protein 4 OS=Homo sapiens OX=9606 GN=OTUD4 PE=1 SV=4" "0.000" "False" "40.907" "12" "10" "11" "10" "1114" "124.0" "6.71" "47.58" "10" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02338" "54726" "ENSG00000164164" "OTUD4" "B4DYS4; hsa:54726; Q01804; Q147U2; Q1ZYK1; Q6PG39; Q96MQ5; Q9NT94; Q9UPV6" "" "" "0" "0" "0.988" "0.976" "1.028" "0.996" "0.959" "1.016" "1.037" "1.016" "1.004" "855.0" "844.6" "834.7" "878.8" "851.7" "820.3" "868.3" "886.5" "868.5" "858.8" "" "" "" "" "" "" "" "" "" "" "768.8" "683.4" "755.0" "857.8" "702.9" "820.3" "650.2" "783.0" "777.1" "306.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "523405854747225660" "False" "High" "IsMasterProtein" "Q16222" "UDP-N-acetylhexosamine pyrophosphorylase OS=Homo sapiens OX=9606 GN=UAP1 PE=1 SV=3" "0.000" "False" "40.906" "21" "10" "14" "8" "522" "58.7" "6.33" "52.10" "10" "other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf01704" "6675" "ENSG00000117143" "UAP1" "B2R6R8; hsa:6675; Q16222; Q5VTA9; Q5VTB0; Q5VTB1; Q96GM2" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.031" "1.209" "0.981" "1.078" "1.090" "1.016" "1.025" "1.111" "0.890" "984.1" "1014.8" "1190.0" "965.5" "1061.3" "1072.8" "999.9" "1009.2" "1093.7" "875.7" "" "" "" "" "" "" "" "" "" "" "884.8" "821.1" "1076.4" "942.4" "875.8" "1072.8" "748.7" "891.4" "978.6" "312.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3836342718594531018" "False" "High" "IsMasterProtein" "O94921" "Cyclin-dependent kinase 14 OS=Homo sapiens OX=9606 GN=CDK14 PE=1 SV=3" "0.000" "False" "40.898" "28" "12" "19" "11" "469" "53.0" "8.92" "68.25" "12" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5218" "ENSG00000058091" "CDK14" "A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2; hsa:5218; O94921; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0" "" "" "0" "0" "1.051" "1.007" "1.012" "1.058" "0.962" "1.071" "1.065" "0.994" "0.900" "1003.7" "1054.7" "1010.6" "1016.1" "1062.3" "966.0" "1074.6" "1069.3" "997.4" "903.6" "" "" "" "" "" "" "" "" "" "" "902.4" "853.4" "914.1" "991.9" "876.6" "966.0" "804.6" "944.5" "892.5" "322.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4976528031312254709" "False" "High" "IsMasterProtein" "Q92506" "(3R)-3-hydroxyacyl-CoA dehydrogenase OS=Homo sapiens OX=9606 GN=HSD17B8 PE=1 SV=2" "0.000" "False" "40.884" "43" "9" "16" "9" "261" "27.0" "6.54" "59.06" "9" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf13561" "7923" "ENSG00000112474; ENSG00000204228; ENSG00000225312; ENSG00000228357; ENSG00000228712; ENSG00000232357" "HSD17B8" "A6NLX7; hsa:7923; Q5STP7; Q92506; Q9UIQ1" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.006" "1.011" "0.927" "1.007" "0.997" "0.961" "0.983" "1.046" "0.768" "886.2" "891.4" "895.7" "821.1" "892.6" "883.6" "851.7" "871.0" "927.0" "680.3" "" "" "" "" "" "" "" "" "" "" "796.8" "721.3" "810.2" "801.5" "736.6" "883.6" "637.8" "769.3" "829.5" "242.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8914003618785624230" "False" "High" "IsMasterProtein" "O75934" "Pre-mRNA-splicing factor SPF27 OS=Homo sapiens OX=9606 GN=BCAS2 PE=1 SV=1" "0.000" "False" "40.881" "45" "8" "15" "8" "225" "26.1" "5.66" "59.56" "8" "RNA metabolism OR transcription;other metabolic processes" "cytoskeleton;nucleus;other cell component" "" "Pf05700" "10286" "ENSG00000116752" "BCAS2" "hsa:10286; O75934; Q6FGS0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.967" "1.002" "0.953" "1.038" "1.028" "0.987" "1.009" "1.004" "0.997" "1593.6" "1541.0" "1596.9" "1519.0" "1654.1" "1638.6" "1573.6" "1608.6" "1600.0" "1588.2" "" "" "" "" "" "" "" "" "" "" "1432.8" "1246.9" "1444.4" "1482.7" "1365.0" "1638.6" "1178.3" "1420.8" "1431.7" "566.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3889272514054364250" "False" "High" "IsMasterProtein" "O15541" "E3 ubiquitin-protein ligase RNF113A OS=Homo sapiens OX=9606 GN=RNF113A PE=1 SV=1" "0.000" "False" "40.877" "43" "11" "22" "11" "343" "38.8" "5.69" "66.14" "11" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00642, Pf13920" "7737" "ENSG00000125352" "RNF113A" "B2RBR7; hsa:7737; O15541" "" "mRNA Splicing - Major Pathway" "1" "0" "0.930" "1.024" "0.961" "1.046" "1.024" "0.981" "1.041" "1.060" "0.793" "1089.0" "1012.6" "1115.3" "1046.1" "1138.6" "1114.8" "1068.5" "1133.8" "1154.2" "863.5" "" "" "" "" "" "" "" "" "" "" "979.1" "819.3" "1008.8" "1021.2" "939.6" "1114.8" "800.1" "1001.4" "1032.8" "308.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3878380865412542485" "False" "High" "IsMasterProtein" "Q96G01" "Protein bicaudal D homolog 1 OS=Homo sapiens OX=9606 GN=BICD1 PE=1 SV=3" "0.000" "False" "40.837" "11" "11" "16" "5" "975" "110.7" "5.81" "55.18" "11" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf09730" "636" "ENSG00000151746" "BICD1" "A8K2C3; F8W113; hsa:636; O43892; O43893; Q96G01" "" "COPI-independent Golgi-to-ER retrograde traffic" "1" "0" "1.064" "1.077" "1.001" "1.071" "1.083" "1.092" "1.130" "1.154" "1.395" "148.1" "157.6" "159.4" "148.3" "158.6" "160.3" "161.8" "167.3" "170.9" "206.6" "" "" "" "" "" "" "" "" "" "" "133.1" "127.6" "144.2" "144.7" "130.9" "160.3" "121.1" "147.8" "152.9" "73.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213729863308039280" "False" "High" "IsMasterProtein" "Q14331" "Protein FRG1 OS=Homo sapiens OX=9606 GN=FRG1 PE=1 SV=1" "0.000" "False" "40.825" "33" "9" "14" "9" "258" "29.2" "9.01" "50.65" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf06229" "2483" "ENSG00000109536; ENSG00000275145; ENSG00000283153; ENSG00000283630" "FRG1" "A8K775; hsa:2483; Q14331" "" "" "0" "0" "0.946" "0.886" "0.994" "0.963" "0.948" "0.928" "0.924" "0.873" "1.007" "1840.0" "1741.1" "1630.1" "1829.0" "1772.4" "1744.5" "1706.9" "1700.7" "1606.3" "1852.9" "" "" "" "" "" "" "" "" "" "" "1654.4" "1408.8" "1474.5" "1785.4" "1462.6" "1744.5" "1278.1" "1502.2" "1437.3" "661.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6312780505627043912" "False" "High" "IsMasterProtein" "Q96E39" "RNA binding motif protein, X-linked-like-1 OS=Homo sapiens OX=9606 GN=RBMXL1 PE=1 SV=1" "0.000" "False" "40.805" "29" "12" "16" "2" "390" "42.1" "9.89" "46.64" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf08081" "494115" "ENSG00000213516" "RBMXL1" "hsa:494115; Q96E39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3472433998448837783" "False" "High" "IsMasterProtein" "O75323" "Protein NipSnap homolog 2 OS=Homo sapiens OX=9606 GN=NIPSNAP2 PE=1 SV=1" "0.000" "False" "40.794" "31" "9" "16" "7" "286" "33.7" "9.36" "58.25" "9" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "" "Pf07978" "2631" "ENSG00000146729" "NIPSNAP2" "C9IYJ3; hsa:2631; O43801; O75323; Q53X96" "" "RHOJ GTPase cycle; RHOH GTPase cycle" "2" "0" "1.001" "1.043" "1.056" "1.027" "1.014" "0.998" "1.066" "1.052" "0.783" "1524.6" "1525.5" "1590.7" "1609.3" "1566.3" "1545.3" "1521.0" "1624.7" "1603.5" "1194.1" "" "" "" "" "" "" "" "" "" "" "1370.8" "1234.3" "1438.9" "1570.9" "1292.5" "1545.3" "1138.9" "1435.1" "1434.8" "426.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2007854671863603578" "False" "High" "IsMasterProtein" "P46734" "Dual specificity mitogen-activated protein kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP2K3 PE=1 SV=2" "0.000" "False" "40.778" "31" "9" "11" "5" "347" "39.3" "7.43" "44.85" "9" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5606" "ENSG00000034152" "MAP2K3" "B3KSK7; hsa:5606; P46734; Q99441; Q9UE71; Q9UE72" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Endoderm differentiation; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; activated TAK1 mediates p38 MAPK activation" "34" "3" "1.196" "1.090" "1.030" "1.075" "1.139" "1.118" "1.126" "1.235" "1.230" "1080.9" "1292.5" "1177.7" "1113.0" "1161.7" "1231.3" "1208.5" "1217.1" "1335.3" "1329.1" "" "" "" "" "" "" "" "" "" "" "971.8" "1045.8" "1065.3" "1086.4" "958.7" "1231.3" "904.9" "1075.0" "1194.8" "474.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3380259188437483549" "False" "High" "IsMasterProtein" "Q9NQ88" "Fructose-2,6-bisphosphatase TIGAR OS=Homo sapiens OX=9606 GN=TIGAR PE=1 SV=1" "0.000" "False" "40.760" "30" "8" "16" "8" "270" "30.0" "7.69" "69.52" "8" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00300" "57103" "ENSG00000078237" "TIGAR" "B2R840; hsa:57103; Q9NQ88" "Metabolic reprogramming in colon cancer; p53 transcriptional gene network" "TP53 Regulates Metabolic Genes" "3" "0" "1.050" "1.124" "1.069" "1.030" "1.178" "0.977" "1.057" "1.118" "0.899" "1467.7" "1541.1" "1649.4" "1569.5" "1512.0" "1729.6" "1434.1" "1551.8" "1641.6" "1319.1" "" "" "" "" "" "" "" "" "" "" "1319.6" "1247.0" "1491.9" "1532.1" "1247.7" "1729.6" "1073.8" "1370.7" "1468.9" "470.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6421392599925785436" "False" "High" "IsMasterProtein" "Q9HD15" "Steroid receptor RNA activator 1 OS=Homo sapiens OX=9606 GN=SRA1 PE=1 SV=2" "0.000" "False" "40.757" "45" "9" "16" "9" "224" "24.4" "7.50" "55.90" "9" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07304" "10011" "ENSG00000213523" "SRA1" "hsa:10011; Q6NVU9; Q8IXM1; Q9HD13; Q9HD14; Q9HD15" "" "" "0" "0" "1.006" "1.022" "0.959" "1.071" "1.048" "0.990" "1.119" "1.057" "0.849" "1318.6" "1327.1" "1348.1" "1264.7" "1412.3" "1381.9" "1306.0" "1475.7" "1393.7" "1120.1" "" "" "" "" "" "" "" "" "" "" "1185.6" "1073.9" "1219.4" "1234.5" "1165.5" "1381.9" "977.9" "1303.4" "1247.0" "399.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4838480320139969571" "False" "High" "IsMasterProtein" "Q13951" "Core-binding factor subunit beta OS=Homo sapiens OX=9606 GN=CBFB PE=1 SV=2" "0.000" "False" "40.755" "35" "7" "22" "7" "182" "21.5" "6.60" "77.14" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02312" "865" "ENSG00000067955" "CBFB" "A8K347; hsa:865; Q13124; Q13951; Q9HCT2" "Dual hijack model of Vif in HIV infection; Hijack of ubiquitination by SARS-CoV-2" "RUNX2 regulates osteoblast differentiation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of RUNX3 expression and activity; Estrogen-dependent gene expression; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Transcriptional regulation of granulopoiesis; RUNX2 regulates genes involved in cell migration; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX2 regulates chondrocyte maturation; RUNX3 Regulates Immune Response and Cell Migration; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling; RUNX3 regulates RUNX1-mediated transcription" "27" "0" "0.994" "1.022" "0.969" "1.053" "1.105" "1.060" "1.076" "0.996" "1.218" "1717.9" "1708.1" "1756.0" "1664.7" "1808.8" "1898.5" "1821.2" "1848.9" "1711.9" "2092.4" "" "" "" "" "" "" "" "" "" "" "1544.6" "1382.2" "1588.4" "1625.0" "1492.7" "1898.5" "1363.7" "1633.0" "1531.8" "746.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7811403610276720073" "False" "High" "IsMasterProtein" "Q99543" "DnaJ homolog subfamily C member 2 OS=Homo sapiens OX=9606 GN=DNAJC2 PE=1 SV=4" "0.000" "False" "40.755" "24" "14" "16" "14" "621" "72.0" "8.70" "52.48" "14" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "translation activity;other molecular function" "Pf00226, Pf00249, Pf16717" "27000" "ENSG00000105821" "DNAJC2" "A4VCI0; hsa:27000; Q99543; Q9BVX1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.939" "0.987" "0.908" "0.891" "1.001" "0.962" "0.882" "1.004" "4.595" "752.1" "706.6" "742.4" "683.0" "670.2" "752.7" "723.3" "663.3" "755.2" "3456.3" "" "" "" "" "" "" "" "" "" "" "676.2" "571.7" "671.5" "666.7" "553.1" "752.7" "541.6" "585.8" "675.8" "1233.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3767865638315377274" "False" "High" "IsMasterProtein" "O60684" "Importin subunit alpha-7 OS=Homo sapiens OX=9606 GN=KPNA6 PE=1 SV=1" "0.000" "False" "40.750" "22" "10" "16" "4" "536" "60.0" "4.98" "56.88" "10" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00514, Pf01749, Pf16186" "23633" "ENSG00000025800" "KPNA6" "B2RDC7; D3DPP5; hsa:23633; O60684; Q5VVU3" "" "Assembly of the ORC complex at the origin of replication" "1" "0" "1.027" "1.034" "0.875" "0.996" "0.893" "1.038" "0.963" "0.921" "1.710" "348.7" "358.1" "360.6" "305.1" "347.2" "311.5" "362.0" "335.9" "321.2" "596.4" "" "" "" "" "" "" "" "" "" "" "313.5" "289.8" "326.1" "297.8" "286.5" "311.5" "271.1" "296.7" "287.4" "212.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2510158146736873084" "False" "High" "IsMasterProtein" "P29084" "Transcription initiation factor IIE subunit beta OS=Homo sapiens OX=9606 GN=GTF2E2 PE=1 SV=1" "0.000" "False" "40.747" "42" "11" "13" "11" "291" "33.0" "9.66" "47.13" "11" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf02186, Pf18121" "2961" "ENSG00000197265" "GTF2E2" "D3DSV2; P29084; Q9H2B9" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.949" "0.958" "0.994" "0.981" "1.000" "1.021" "0.993" "1.013" "1.035" "1041.8" "988.6" "998.2" "1035.7" "1022.0" "1041.4" "1063.9" "1035.0" "1054.9" "1077.9" "" "" "" "" "" "" "" "" "" "" "936.7" "799.9" "902.9" "1011.0" "843.4" "1041.4" "796.6" "914.2" "943.9" "384.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874885037648560876" "False" "High" "IsMasterProtein" "O60869" "Endothelial differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDF1 PE=1 SV=1" "0.000" "False" "40.737" "48" "11" "26" "11" "148" "16.4" "9.95" "79.66" "11" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01381, Pf08523" "8721" "ENSG00000107223" "EDF1" "hsa:8721; O60869; Q5T5T2; Q9UIM1" "" "" "0" "0" "1.043" "0.975" "0.991" "0.881" "0.996" "0.940" "1.023" "0.857" "0.733" "3379.1" "3524.4" "3293.6" "3349.6" "2976.3" "3365.9" "3176.0" "3457.7" "2895.9" "2475.3" "" "" "" "" "" "" "" "" "" "" "3038.1" "2851.8" "2979.2" "3269.7" "2456.1" "3365.9" "2378.1" "3054.0" "2591.2" "883.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492366251309725518" "False" "High" "IsMasterProtein" "Q9BZ23" "Pantothenate kinase 2, mitochondrial OS=Homo sapiens OX=9606 GN=PANK2 PE=1 SV=3" "0.000" "False" "40.713" "18" "8" "10" "5" "570" "62.6" "9.28" "41.80" "8" "other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf03630" "80025" "ENSG00000125779" "PANK2" "B1AK33; B2Z3X0; D3DVZ0; hsa:80025; Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9BZ23; Q9HAF2" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Coenzyme A biosynthesis" "3" "2" "1.012" "0.991" "0.983" "1.038" "0.978" "1.021" "1.042" "0.983" "0.814" "677.3" "685.7" "671.3" "665.7" "703.3" "662.5" "691.6" "706.0" "665.7" "551.1" "" "" "" "" "" "" "" "" "" "" "609.0" "554.8" "607.3" "649.8" "580.4" "662.5" "517.9" "623.6" "595.6" "196.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532813342924820659" "False" "High" "IsMasterProtein" "Q9Y383" "Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens OX=9606 GN=LUC7L2 PE=1 SV=2" "0.000" "False" "40.713" "20" "8" "14" "6" "392" "46.5" "10.01" "54.82" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "51631" "ENSG00000146963" "LUC7L2" "B7Z500; hsa:51631; Q8IUP9; Q9NVL3; Q9NVN7; Q9UQN1; Q9Y383" "" "" "0" "2" "0.994" "0.899" "0.980" "0.978" "0.972" "1.001" "1.007" "0.995" "1.017" "1520.4" "1510.8" "1366.5" "1489.8" "1487.0" "1477.4" "1522.4" "1531.5" "1513.3" "1545.9" "" "" "" "" "" "" "" "" "" "" "1367.0" "1222.5" "1236.1" "1454.2" "1227.1" "1477.4" "1139.9" "1352.7" "1354.1" "551.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7583524308725557668" "False" "High" "IsMasterProtein" "Q96J01" "THO complex subunit 3 OS=Homo sapiens OX=9606 GN=THOC3 PE=1 SV=1" "0.000" "False" "40.621" "29" "9" "16" "9" "351" "38.7" "6.09" "58.38" "9" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00400, Pf07676, Pf12894" "84321" "ENSG00000051596" "THOC3" "hsa:84321; Q6NZ53; Q96J01" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.008" "0.961" "0.962" "0.965" "0.978" "0.976" "0.946" "0.992" "1.035" "1915.6" "1931.4" "1841.8" "1843.6" "1849.2" "1873.0" "1868.9" "1812.7" "1900.4" "1982.3" "" "" "" "" "" "" "" "" "" "" "1722.3" "1562.8" "1665.9" "1799.6" "1526.0" "1873.0" "1399.4" "1601.1" "1700.4" "707.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4122244859069195901" "False" "High" "IsMasterProtein" "Q9NVM6" "DnaJ homolog subfamily C member 17 OS=Homo sapiens OX=9606 GN=DNAJC17 PE=1 SV=1" "0.000" "False" "40.575" "29" "7" "12" "7" "304" "34.7" "8.53" "39.75" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf00226" "55192" "ENSG00000104129" "DNAJC17" "hsa:55192; Q9NVM6" "" "" "0" "0" "0.974" "1.025" "0.940" "1.039" "0.995" "1.094" "1.055" "0.943" "0.880" "598.6" "582.9" "613.6" "562.4" "622.1" "595.4" "654.8" "631.8" "564.6" "526.6" "" "" "" "" "" "" "" "" "" "" "538.2" "471.7" "555.0" "549.0" "513.3" "595.4" "490.3" "558.0" "505.2" "188.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634668291009869452" "False" "High" "IsMasterProtein" "Q9UNP9" "Peptidyl-prolyl cis-trans isomerase E OS=Homo sapiens OX=9606 GN=PPIE PE=1 SV=1" "0.000" "False" "40.555" "25" "9" "15" "8" "301" "33.4" "5.60" "51.97" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00160" "10450" "ENSG00000084072" "PPIE" "B2R971; hsa:10450; O43634; O43635; Q32Q72; Q3S611; Q5TGA0; Q5TGA2; Q5TGA3; Q9UIZ5; Q9UNP9" "" "Neutrophil degranulation; mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "0.676" "1.455" "0.821" "0.735" "0.775" "0.753" "0.772" "0.780" "0.839" "1153.3" "780.0" "1678.2" "947.0" "848.2" "893.4" "868.4" "890.4" "899.8" "967.3" "" "" "" "" "" "" "" "" "" "" "1036.9" "631.2" "1518.0" "924.4" "699.9" "893.4" "650.2" "786.5" "805.1" "345.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3013067335374835843" "False" "High" "IsMasterProtein" "Q13153" "Serine/threonine-protein kinase PAK 1 OS=Homo sapiens OX=9606 GN=PAK1 PE=1 SV=2" "0.000" "False" "40.531" "18" "9" "17" "4" "545" "60.6" "5.76" "56.24" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00786" "5058" "ENSG00000149269" "PAK1" "hsa:5058; O75561; Q13153; Q13567; Q32M53; Q32M54; Q86W79" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Androgen receptor network in prostate cancer; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; Gastrin signaling pathway; Melanoma; Pleural mesothelioma; Regulation of actin cytoskeleton; ErbB signaling pathway; T-cell receptor signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOU GTPase cycle; MAPK6/MAPK4 signaling; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; Generation of second messenger molecules; RHOQ GTPase cycle; RHOV GTPase cycle; EPHB-mediated forward signaling; Ephrin signaling; G beta:gamma signalling through CDC42; Sema3A PAK dependent Axon repulsion; Signal transduction by L1; Smooth Muscle Contraction; RHO GTPases activate PKNs; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs; DSCAM interactions; VEGFR2 mediated vascular permeability; Activation of RAC1; RHOH GTPase cycle; CD209 (DC-SIGN) signaling; CD28 dependent Vav1 pathway" "56" "0" "1.891" "1.170" "0.877" "1.712" "1.215" "1.339" "0.992" "1.085" "0.851" "343.7" "649.9" "402.0" "301.3" "588.5" "417.5" "460.2" "340.9" "373.0" "292.4" "" "" "" "" "" "" "" "" "" "" "309.0" "525.9" "363.7" "294.1" "485.7" "417.5" "344.6" "301.1" "333.8" "104.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2331175161516182807" "False" "High" "IsMasterProtein" "Q6YN16" "Hydroxysteroid dehydrogenase-like protein 2 OS=Homo sapiens OX=9606 GN=HSDL2 PE=1 SV=1" "0.000" "False" "40.527" "29" "10" "13" "10" "418" "45.4" "7.99" "51.26" "10" "" "mitochondrion;other cytoplasmic organelle" "other molecular function" "Pf00106, Pf02036" "84263" "ENSG00000119471" "HSDL2" "A8K1L4; A8K8X1; A8MSV3; hsa:84263; Q658M8; Q6YN16; Q9BT58" "" "" "0" "0" "1.005" "1.020" "0.983" "1.033" "0.973" "1.029" "1.034" "1.022" "0.934" "1330.6" "1337.3" "1357.1" "1308.1" "1374.5" "1294.3" "1369.4" "1375.6" "1359.8" "1242.6" "" "" "" "" "" "" "" "" "" "" "1196.3" "1082.1" "1227.6" "1276.9" "1134.3" "1294.3" "1025.4" "1215.0" "1216.7" "443.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3430961605673792526" "False" "High" "IsMasterProtein" "Q13033" "Striatin-3 OS=Homo sapiens OX=9606 GN=STRN3 PE=1 SV=3" "0.000" "False" "40.483" "16" "11" "12" "10" "797" "87.2" "5.36" "48.13" "11" "other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400, Pf08232" "29966" "ENSG00000196792" "STRN3" "A2RTX7; A6NHZ7; hsa:29966; Q13033; Q9NRA5" "" "" "0" "1" "1.062" "1.037" "1.050" "1.046" "1.028" "1.005" "1.067" "1.205" "0.897" "987.7" "1048.5" "1023.8" "1036.6" "1033.6" "1015.1" "992.8" "1053.4" "1190.0" "886.2" "" "" "" "" "" "" "" "" "" "" "888.0" "848.4" "926.0" "1011.9" "852.9" "1015.1" "743.4" "930.4" "1064.8" "316.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8840476301148053294" "False" "High" "IsMasterProtein" "Q9NVI1" "Fanconi anemia group I protein OS=Homo sapiens OX=9606 GN=FANCI PE=1 SV=4" "0.000" "False" "40.467" "10" "12" "12" "12" "1328" "149.2" "6.74" "45.35" "12" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf14674, Pf14675, Pf14676, Pf14677, Pf14678, Pf14679, Pf14680" "55215" "ENSG00000140525" "FANCI" "A4ZVE4; A5YMH4; A6NJZ0; hsa:55215; Q96JN1; Q96ST0; Q9BT96; Q9NVI1" "Gastric cancer network 2; DNA repair pathways, full network; 15q11q13 copy number variation" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "5" "0" "0.916" "0.832" "0.907" "0.925" "0.856" "1.057" "0.748" "0.723" "5.696" "368.0" "337.0" "306.1" "333.9" "340.3" "314.9" "389.1" "275.4" "266.1" "2096.0" "" "" "" "" "" "" "" "" "" "" "330.8" "272.7" "276.9" "325.9" "280.8" "314.9" "291.3" "243.3" "238.1" "748.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157210626844435621" "False" "High" "IsMasterProtein" "Q8IUI4" "Putative protein SNX29P2 OS=Homo sapiens OX=9606 GN=SNX29P2 PE=5 SV=2" "0.000" "False" "40.406" "37" "7" "11" "4" "249" "27.2" "4.94" "54.50" "7" "" "" "" "" "" "" "SNX29P2" "Q8IUI4" "" "" "0" "3" "0.977" "0.974" "1.068" "1.025" "0.993" "1.034" "1.147" "1.068" "1.416" "1474.8" "1440.7" "1436.1" "1575.0" "1511.6" "1464.6" "1524.9" "1691.0" "1575.3" "2087.7" "" "" "" "" "" "" "" "" "" "" "1326.0" "1165.7" "1299.0" "1537.4" "1247.4" "1464.6" "1141.8" "1493.6" "1409.6" "745.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2819715853452011200" "False" "High" "IsMasterProtein" "Q8WUD4" "Coiled-coil domain-containing protein 12 OS=Homo sapiens OX=9606 GN=CCDC12 PE=1 SV=1" "0.000" "False" "40.400" "50" "8" "15" "8" "166" "19.2" "7.34" "61.29" "8" "" "nucleus" "" "Pf08315" "151903" "ENSG00000160799" "CCDC12" "hsa:151903; Q8N8I4; Q8WUD4" "" "mRNA Splicing - Major Pathway" "1" "0" "0.781" "0.899" "0.933" "1.002" "0.901" "1.009" "1.093" "0.963" "0.777" "1196.8" "934.1" "1076.0" "1116.1" "1198.8" "1078.5" "1207.7" "1307.6" "1152.0" "929.8" "" "" "" "" "" "" "" "" "" "" "1076.1" "755.9" "973.3" "1089.5" "989.3" "1078.5" "904.3" "1155.0" "1030.8" "331.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485093718878693272" "False" "High" "IsMasterProtein" "P09917" "Polyunsaturated fatty acid 5-lipoxygenase OS=Homo sapiens OX=9606 GN=ALOX5 PE=1 SV=2" "0.000" "False" "40.381" "20" "11" "14" "11" "674" "77.9" "5.77" "50.82" "11" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00305, Pf01477" "240" "ENSG00000012779; ENSG00000275565" "ALOX5" "B7ZLS0; E5FPY5; E5FPY7; E5FPY8; hsa:240; P09917; Q5JQ14" "Selenium micronutrient network; Vitamin D receptor pathway; Eicosanoid metabolism via lipooxygenases (LOX); Prostaglandin and leukotriene metabolism in senescence ; ALA oxylipin metabolism; Linoleic acid oxylipin metabolism; Lipid metabolism in senescent cells; Urotensin-II-mediated signaling pathway; Leukotriene metabolic pathway; Prostaglandin and leukotriene metabolism in senescence ; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Interleukin-4 and Interleukin-13 signaling; Interleukin-18 signaling; Synthesis of 5-eicosatetraenoic acids; Synthesis of Leukotrienes (LT) and Eoxins (EX); Synthesis of Lipoxins (LX); Biosynthesis of D-series resolvins; Biosynthesis of maresins; Biosynthesis of E-series 18(S)-resolvins; Biosynthesis of aspirin-triggered D-series resolvins; Biosynthesis of E-series 18(R)-resolvins; Biosynthesis of DPAn-3-derived protectins and resolvins; Biosynthesis of DPAn-3-derived maresins; Biosynthesis of DPAn-3-derived 13-series resolvins; Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives" "26" "0" "1.068" "1.088" "0.999" "1.052" "1.098" "1.085" "1.067" "1.100" "0.841" "442.8" "472.8" "481.8" "442.2" "465.7" "486.3" "480.5" "472.6" "486.9" "372.5" "" "" "" "" "" "" "" "" "" "" "398.1" "382.6" "435.8" "431.6" "384.3" "486.3" "359.8" "417.5" "435.7" "133.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3796638279955905475" "False" "High" "IsMasterProtein" "Q9NZ32" "Actin-related protein 10 OS=Homo sapiens OX=9606 GN=ACTR10 PE=1 SV=1" "0.000" "False" "40.367" "29" "9" "12" "9" "417" "46.3" "7.37" "39.89" "9" "transport" "non-structural extracellular;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "" "Pf00022" "55860" "ENSG00000131966" "ACTR10" "hsa:55860; Q9H9Y5; Q9NWY2; Q9NZ32" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Neutrophil degranulation" "5" "0" "1.041" "1.028" "0.977" "1.047" "1.019" "1.013" "1.020" "1.041" "0.872" "742.9" "773.1" "763.9" "725.9" "777.6" "757.3" "752.9" "757.8" "773.1" "647.9" "" "" "" "" "" "" "" "" "" "" "667.9" "625.6" "691.0" "708.5" "641.7" "757.3" "563.7" "669.4" "691.7" "231.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2487901490658103836" "False" "High" "IsMasterProtein" "O75995" "SAM and SH3 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=SASH3 PE=1 SV=2" "0.000" "False" "40.335" "28" "7" "11" "7" "380" "41.6" "5.27" "43.80" "7" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf00536, Pf07653, Pf12485" "54440" "ENSG00000122122" "SASH3" "A6NCH1; A8K7K8; hsa:54440; O75995; Q5JZ38" "" "" "0" "0" "0.892" "0.895" "0.974" "1.037" "0.906" "1.034" "1.034" "0.902" "0.868" "699.0" "623.4" "625.7" "680.8" "725.0" "633.5" "722.8" "722.4" "630.5" "606.9" "" "" "" "" "" "" "" "" "" "" "628.5" "504.5" "566.0" "664.6" "598.3" "633.5" "541.2" "638.1" "564.1" "216.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7576876112341409561" "False" "High" "IsMasterProtein" "O43813" "Glutathione S-transferase LANCL1 OS=Homo sapiens OX=9606 GN=LANCL1 PE=1 SV=1" "0.000" "False" "40.314" "29" "10" "17" "10" "399" "45.3" "7.75" "59.25" "10" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05147" "10314" "ENSG00000115365" "LANCL1" "hsa:10314; O43813" "" "" "0" "0" "1.008" "0.999" "1.028" "0.983" "0.950" "0.942" "0.967" "1.003" "0.740" "1621.9" "1635.4" "1619.5" "1667.0" "1594.1" "1540.5" "1528.1" "1568.7" "1626.4" "1200.9" "" "" "" "" "" "" "" "" "" "" "1458.2" "1323.3" "1464.9" "1627.3" "1315.5" "1540.5" "1144.2" "1385.6" "1455.3" "428.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9069432479560653681" "False" "High" "IsMasterProtein" "Q08AM6" "Protein VAC14 homolog OS=Homo sapiens OX=9606 GN=VAC14 PE=1 SV=1" "0.000" "False" "40.308" "18" "12" "15" "12" "782" "87.9" "6.13" "52.82" "12" "other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf11916, Pf12755" "55697" "ENSG00000103043" "VAC14" "B3KPJ5; B3KSM8; hsa:55697; Q08AM6; Q13174; Q6IA12; Q7L4Y1; Q9BW96; Q9H6V6" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "0.984" "0.928" "0.906" "0.982" "0.954" "0.927" "1.016" "0.938" "0.876" "553.2" "544.1" "513.2" "501.4" "543.2" "527.7" "512.8" "562.1" "519.1" "484.5" "" "" "" "" "" "" "" "" "" "" "497.4" "440.3" "464.2" "489.5" "448.3" "527.7" "384.0" "496.5" "464.4" "172.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3688625229951110619" "False" "High" "IsMasterProtein" "Cont_P02538" "Keratin, type II cytoskeletal 6A OS=Homo sapiens OX=9606 GN=KRT6A PE=1 SV=3" "0.000" "True" "40.291" "20" "14" "17" "1" "564" "60.0" "8.00" "53.70" "14" "cell organization and biogenesis;stress response;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity;cytoskeletal activity" "Pf00038, Pf16208" "3853" "ENSG00000205420" "KRT6A" "A0A0S2Z428; A4QPC1; hsa:3853; P02538; P48667; Q08AR4; Q6NT67; Q96CL4" "Ectoderm differentiation; Ectoderm differentiation; Pancreatic cancer subtypes" "Formation of the cornified envelope" "5" "2" "0.158" "0.147" "0.254" "0.161" "0.526" "0.208" "0.159" "0.134" "0.177" "930.7" "147.1" "136.9" "236.6" "150.1" "489.3" "193.5" "148.2" "124.6" "164.6" "" "" "" "" "" "" "" "" "" "" "836.7" "119.1" "123.8" "231.0" "123.9" "489.3" "144.9" "130.9" "111.5" "58.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6052535811300559173" "False" "High" "IsMasterProtein" "Q2NL82" "Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens OX=9606 GN=TSR1 PE=1 SV=1" "0.000" "False" "40.229" "16" "12" "15" "12" "804" "91.8" "7.42" "45.60" "12" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "55720" "ENSG00000167721" "TSR1" "hsa:55720; Q2NL82; Q8WUY5; Q9NVT0; Q9P2E6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.146" "1.099" "1.012" "1.216" "1.140" "1.215" "1.128" "1.002" "1.772" "462.4" "530.1" "508.1" "467.7" "562.4" "527.1" "561.6" "521.8" "463.3" "819.5" "" "" "" "" "" "" "" "" "" "" "415.7" "428.9" "459.6" "456.6" "464.1" "527.1" "420.5" "460.9" "414.6" "292.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "212659989141045460" "False" "High" "IsMasterProtein" "P78356" "Phosphatidylinositol 5-phosphate 4-kinase type-2 beta OS=Homo sapiens OX=9606 GN=PIP4K2B PE=1 SV=1" "0.000" "False" "40.219" "23" "10" "16" "6" "416" "47.3" "7.33" "59.49" "10" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf01504" "8396" "ENSG00000276293; ENSG00000277292" "PIP4K2B" "hsa:8396; P78356; Q5U0E8; Q8TBP2" "Regulation of actin cytoskeleton; 17q12 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "6" "0" "1.019" "1.071" "0.949" "1.096" "1.015" "0.999" "0.971" "1.222" "0.995" "475.0" "483.8" "508.8" "450.8" "520.4" "482.1" "474.5" "461.1" "580.6" "472.4" "" "" "" "" "" "" "" "" "" "" "427.0" "391.5" "460.2" "440.0" "429.4" "482.1" "355.3" "407.3" "519.5" "168.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375658416039081200" "False" "High" "IsMasterProtein" "Q9GZU8" "PSME3-interacting protein OS=Homo sapiens OX=9606 GN=PSME3IP1 PE=1 SV=1" "0.000" "False" "40.214" "51" "14" "20" "14" "254" "28.9" "5.45" "69.96" "14" "other biological processes" "nucleus;other cell component" "" "Pf10187" "80011" "ENSG00000172775" "PSME3IP1" "hsa:80011; Q9GZU8" "" "" "0" "0" "0.951" "0.996" "0.961" "0.973" "1.037" "0.972" "1.025" "1.012" "0.856" "2089.7" "1986.6" "2082.0" "2008.6" "2033.0" "2166.2" "2030.7" "2141.9" "2114.5" "1788.9" "" "" "" "" "" "" "" "" "" "" "1878.9" "1607.5" "1883.2" "1960.7" "1677.6" "2166.2" "1520.6" "1891.9" "1892.0" "638.6" "13" "13" "13" "13" "13" "13" "13" "13" "13" "13" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5464068146291938331" "False" "High" "IsMasterProtein" "P49840" "Glycogen synthase kinase-3 alpha OS=Homo sapiens OX=9606 GN=GSK3A PE=1 SV=2" "0.000" "False" "40.208" "20" "11" "20" "5" "483" "50.9" "8.75" "71.92" "11" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "2931" "ENSG00000105723" "GSK3A" "hsa:2931; O14959; P49840" "IL-5 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Wnt signaling pathway; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Nonalcoholic fatty liver disease; Insulin signaling; Glycogen synthesis and degradation; HDAC6 interactions in the central nervous system" "Constitutive Signaling by AKT1 E17K in Cancer; XBP1(S) activates chaperone genes; AKT phosphorylates targets in the cytosol; Suppression of apoptosis; Maturation of nucleoprotein; Maturation of nucleoprotein" "18" "0" "1.008" "0.992" "1.085" "1.078" "1.103" "1.070" "1.020" "1.079" "1.045" "360.9" "363.7" "357.9" "391.7" "389.1" "398.3" "386.2" "368.0" "389.4" "377.3" "" "" "" "" "" "" "" "" "" "" "324.5" "294.3" "323.8" "382.4" "321.1" "398.3" "289.2" "325.1" "348.4" "134.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819630258189506626" "False" "High" "IsMasterProtein" "P02792" "Ferritin light chain OS=Homo sapiens OX=9606 GN=FTL PE=1 SV=2" "0.000" "False" "40.204" "43" "7" "22" "7" "175" "20.0" "5.78" "77.47" "7" "transport;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00210" "2512" "ENSG00000087086" "FTL" "B2R4B9; hsa:2512; P02792; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8" "Nuclear receptors meta-pathway; NRF2 pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Iron metabolism disorders" "Scavenging by Class A Receptors; Neutrophil degranulation; Golgi Associated Vesicle Biogenesis; Iron uptake and transport" "9" "0" "0.920" "1.026" "1.002" "1.029" "0.949" "0.999" "1.040" "1.072" "0.792" "1761.5" "1620.4" "1806.9" "1764.5" "1811.8" "1672.4" "1758.9" "1831.4" "1887.6" "1396.0" "" "" "" "" "" "" "" "" "" "" "1583.8" "1311.2" "1634.4" "1722.4" "1495.2" "1672.4" "1317.0" "1617.6" "1689.0" "498.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5102173735616793815" "False" "High" "IsMasterProtein" "Q9BWH6" "RNA polymerase II-associated protein 1 OS=Homo sapiens OX=9606 GN=RPAP1 PE=1 SV=3" "0.000" "False" "40.195" "14" "12" "13" "12" "1393" "152.7" "6.38" "38.28" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08620, Pf08621" "26015" "ENSG00000103932" "RPAP1" "hsa:26015; Q9BWH6; Q9H9I2; Q9NSQ5; Q9P2E4; Q9UFS7" "" "" "0" "0" "1.052" "1.027" "0.969" "1.044" "1.049" "1.076" "1.036" "1.071" "1.081" "418.9" "440.7" "430.4" "405.8" "437.2" "439.5" "450.7" "434.0" "448.7" "453.0" "" "" "" "" "" "" "" "" "" "" "376.6" "356.6" "389.3" "396.1" "360.7" "439.5" "337.4" "383.4" "401.5" "161.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3589965409300637784" "False" "High" "IsMasterProtein" "Q14691" "DNA replication complex GINS protein PSF1 OS=Homo sapiens OX=9606 GN=GINS1 PE=1 SV=1" "0.000" "False" "40.178" "53" "9" "15" "9" "196" "23.0" "7.39" "56.43" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf05916" "9837" "ENSG00000101003" "GINS1" "hsa:9837; Q14691; Q9NQE2; Q9NQI7" "" "Unwinding of DNA" "1" "0" "0.980" "1.031" "0.932" "1.008" "0.982" "0.949" "0.995" "0.977" "1.027" "1697.1" "1663.9" "1749.7" "1582.1" "1710.4" "1666.5" "1610.4" "1689.4" "1657.7" "1743.2" "" "" "" "" "" "" "" "" "" "" "1525.8" "1346.4" "1582.7" "1544.3" "1411.4" "1666.5" "1205.8" "1492.2" "1483.3" "622.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276719871576654886" "False" "High" "IsMasterProtein" "Q92917" "G-patch domain and KOW motifs-containing protein OS=Homo sapiens OX=9606 GN=GPKOW PE=1 SV=2" "0.000" "False" "40.102" "27" "10" "13" "10" "476" "52.2" "6.15" "46.39" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf00467, Pf12656" "27238" "ENSG00000068394; ENSG00000292204" "GPKOW" "hsa:27238; Q59EK5; Q92917; Q9BQA8" "" "mRNA Splicing - Major Pathway" "1" "0" "1.049" "1.117" "0.954" "1.035" "1.048" "1.088" "0.950" "0.999" "1.759" "606.0" "636.0" "677.2" "578.4" "627.3" "635.1" "659.6" "575.8" "605.6" "1066.0" "" "" "" "" "" "" "" "" "" "" "544.9" "514.6" "612.5" "564.6" "517.7" "635.1" "493.9" "508.6" "541.9" "380.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "647250025127974157" "False" "High" "IsMasterProtein" "Q15004" "PCNA-associated factor OS=Homo sapiens OX=9606 GN=PCLAF PE=1 SV=1" "0.000" "False" "40.088" "71" "9" "12" "9" "111" "12.0" "9.83" "53.40" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15715" "9768" "ENSG00000166803" "PCLAF" "A6NNU5; A8K3Y3; G9G694; G9G696; hsa:9768; Q15004" "" "Termination of translesion DNA synthesis" "1" "0" "1.014" "2.096" "0.950" "0.948" "2.153" "0.931" "1.034" "2.021" "0.947" "992.4" "1006.4" "2079.8" "942.7" "940.4" "2136.3" "924.3" "1026.4" "2005.3" "939.8" "" "" "" "" "" "" "" "" "" "" "892.3" "814.4" "1881.2" "920.2" "776.1" "2136.3" "692.1" "906.6" "1794.3" "335.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5541233720560719878" "False" "High" "IsMasterProtein" "O43809" "Cleavage and polyadenylation specificity factor subunit 5 OS=Homo sapiens OX=9606 GN=NUDT21 PE=1 SV=1" "0.000" "False" "40.022" "42" "9" "17" "9" "227" "26.2" "8.82" "64.83" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13869" "11051" "ENSG00000167005" "NUDT21" "hsa:11051; O43809; Q6IB85; Q6NE84" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.065" "1.069" "1.019" "1.026" "1.146" "1.039" "1.006" "1.014" "0.701" "2472.2" "2631.8" "2643.3" "2520.1" "2536.1" "2832.3" "2568.2" "2486.3" "2507.1" "1732.8" "" "" "" "" "" "" "" "" "" "" "2222.8" "2129.6" "2390.9" "2460.0" "2092.9" "2832.3" "1923.0" "2196.0" "2243.4" "618.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "984760743341076196" "False" "High" "IsMasterProtein" "Q9Y547" "Intraflagellar transport protein 25 homolog OS=Homo sapiens OX=9606 GN=IFT25 PE=1 SV=1" "0.000" "False" "39.997" "51" "6" "11" "6" "144" "16.3" "5.03" "54.05" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00754" "51668" "ENSG00000081870" "IFT25" "A6NG57; D3DQ45; hsa:51668; Q9Y547; Q9Y684" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); GDNF/RET signaling axis; Alstrom syndrome" "Intraflagellar transport" "6" "0" "1.022" "1.105" "1.113" "1.045" "1.144" "1.046" "1.018" "1.120" "0.798" "954.5" "975.5" "1054.4" "1061.9" "997.2" "1091.6" "998.7" "972.0" "1069.1" "761.5" "" "" "" "" "" "" "" "" "" "" "858.2" "789.3" "953.7" "1036.6" "822.9" "1091.6" "747.8" "858.6" "956.6" "271.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5831318780158998432" "False" "High" "IsMasterProtein" "Q9H0C8" "Integrin-linked kinase-associated serine/threonine phosphatase 2C OS=Homo sapiens OX=9606 GN=ILKAP PE=1 SV=1" "0.000" "False" "39.955" "33" "12" "18" "12" "392" "42.9" "7.09" "56.55" "12" "" "other cell component" "other molecular function" "Pf00481" "80895" "ENSG00000132323" "ILKAP" "B3KM39; hsa:80895; Q9H0C8" "2q37 copy number variation syndrome" "" "1" "0" "1.042" "0.981" "1.002" "1.042" "1.027" "0.970" "1.005" "1.029" "1.254" "1580.4" "1646.5" "1550.7" "1582.9" "1646.0" "1622.6" "1533.3" "1589.1" "1626.8" "1981.9" "" "" "" "" "" "" "" "" "" "" "1420.9" "1332.3" "1402.6" "1545.2" "1358.3" "1622.6" "1148.1" "1403.6" "1455.7" "707.5" "12" "12" "12" "12" "12" "12" "12" "12" "12" "12" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-493599392499449744" "False" "High" "IsMasterProtein" "P53990" "IST1 homolog OS=Homo sapiens OX=9606 GN=IST1 PE=1 SV=1" "0.000" "False" "39.915" "20" "7" "14" "7" "364" "39.7" "5.35" "51.92" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03398" "9798" "ENSG00000182149" "IST1" "A8KAH5; hsa:9798; J3QLU7; P53990; Q3SYM4; Q9BQ81; Q9BWN2" "" "Neutrophil degranulation; Sealing of the nuclear envelope (NE) by ESCRT-III" "2" "0" "0.973" "1.128" "1.006" "0.960" "1.016" "1.072" "0.984" "1.043" "1.272" "1377.1" "1339.6" "1552.8" "1386.0" "1322.6" "1399.1" "1476.1" "1355.1" "1436.0" "1751.9" "" "" "" "" "" "" "" "" "" "" "1238.1" "1084.0" "1404.5" "1352.9" "1091.5" "1399.1" "1105.3" "1196.9" "1284.9" "625.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3220884936245267041" "False" "High" "IsMasterProtein" "Q8WUA7" "TBC1 domain family member 22A OS=Homo sapiens OX=9606 GN=TBC1D22A PE=1 SV=2" "0.000" "False" "39.906" "23" "11" "15" "10" "517" "59.1" "5.97" "47.90" "11" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "25771" "ENSG00000054611" "TBC1D22A" "B0QYI2; B0QYI3; B9A6M3; hsa:25771; Q5TE47; Q6ZUH2; Q8WUA7; Q92680; Q9BVD6; Q9UGG0; Q9UGT2; Q9UGU6; Q9UH25; Q9Y4W5" "" "" "0" "1" "1.099" "0.990" "0.955" "1.098" "1.009" "1.036" "0.981" "1.008" "0.810" "1009.3" "1108.9" "999.6" "963.5" "1108.3" "1018.3" "1045.1" "989.8" "1017.6" "817.2" "" "" "" "" "" "" "" "" "" "" "907.4" "897.3" "904.2" "940.5" "914.6" "1018.3" "782.6" "874.3" "910.6" "291.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5318017384069718868" "False" "High" "IsMasterProtein" "Q9Y5B0" "RNA polymerase II subunit A C-terminal domain phosphatase OS=Homo sapiens OX=9606 GN=CTDP1 PE=1 SV=3" "0.000" "False" "39.887" "14" "14" "17" "14" "961" "104.3" "5.27" "47.87" "14" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00533, Pf03031, Pf09309" "9150" "ENSG00000060069" "CTDP1" "A8MY97; hsa:9150; Q7Z644; Q96BZ1; Q9Y5B0; Q9Y6F5" "" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "0.979" "0.964" "1.016" "1.017" "0.970" "1.035" "1.016" "0.985" "1.918" "1016.9" "995.6" "980.1" "1033.0" "1033.9" "986.9" "1052.6" "1033.3" "1001.4" "1950.6" "" "" "" "" "" "" "" "" "" "" "914.3" "805.6" "886.5" "1008.3" "853.2" "986.9" "788.2" "912.7" "896.0" "696.3" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8339310688111388996" "False" "High" "IsMasterProtein" "Q9HCE5" "N6-adenosine-methyltransferase non-catalytic subunit OS=Homo sapiens OX=9606 GN=METTL14 PE=1 SV=2" "0.000" "False" "39.842" "21" "8" "13" "8" "456" "52.1" "6.21" "52.53" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05063" "57721" "ENSG00000145388" "METTL14" "A6NIG1; hsa:57721; Q969V2; Q9HCE5" "1p36 copy number variation syndrome" "Processing of Capped Intron-Containing Pre-mRNA" "2" "0" "0.962" "0.965" "0.908" "1.005" "0.926" "0.923" "0.962" "0.979" "0.687" "1320.6" "1270.6" "1274.4" "1199.6" "1327.0" "1222.6" "1219.6" "1270.3" "1292.3" "907.7" "" "" "" "" "" "" "" "" "" "" "1187.4" "1028.2" "1152.7" "1171.0" "1095.0" "1222.6" "913.2" "1122.0" "1156.4" "324.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629254407620291846" "False" "High" "IsMasterProtein" "Q15428" "Splicing factor 3A subunit 2 OS=Homo sapiens OX=9606 GN=SF3A2 PE=1 SV=2" "0.000" "False" "39.826" "23" "8" "17" "8" "464" "49.2" "9.64" "60.90" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf12874, Pf16835" "8175" "ENSG00000104897" "SF3A2" "B2RBU1; D6W605; hsa:8175; O75245; Q15428" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.048" "1.016" "0.964" "1.021" "0.959" "0.962" "0.965" "1.019" "1.395" "1525.4" "1599.3" "1550.4" "1470.6" "1557.1" "1462.8" "1467.4" "1472.8" "1554.8" "2127.2" "" "" "" "" "" "" "" "" "" "" "1371.5" "1294.1" "1402.4" "1435.5" "1284.9" "1462.8" "1098.7" "1300.8" "1391.2" "759.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5324652532582305658" "False" "High" "IsMasterProtein" "P53779" "Mitogen-activated protein kinase 10 OS=Homo sapiens OX=9606 GN=MAPK10 PE=1 SV=2" "0.000" "False" "39.788" "26" "11" "17" "5" "464" "52.6" "6.79" "53.79" "11" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5602" "ENSG00000109339" "MAPK10" "A6NFS3; A6NG28; B3KQ94; hsa:5602; P53779; Q15707; Q49AP1" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Focal adhesion; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; Wnt signaling pathway and pluripotency; Oxidative stress response; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; MAPK cascade; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; G13 signaling pathway; 5q35 copy number variation; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "36" "5" "0.994" "0.952" "0.938" "0.987" "0.905" "0.952" "0.947" "0.905" "0.920" "1400.0" "1391.4" "1333.4" "1312.7" "1381.4" "1266.3" "1332.7" "1325.8" "1267.5" "1288.4" "" "" "" "" "" "" "" "" "" "" "1258.8" "1125.9" "1206.1" "1281.4" "1140.0" "1266.3" "997.9" "1171.0" "1134.1" "459.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9147063981897791280" "False" "High" "IsMasterProtein" "P04632" "Calpain small subunit 1 OS=Homo sapiens OX=9606 GN=CAPNS1 PE=1 SV=1" "0.000" "False" "39.748" "38" "7" "20" "7" "268" "28.3" "5.20" "80.96" "7" "protein metabolism;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "" "826" "ENSG00000126247" "CAPNS1" "A8K0P1; hsa:826; P04632; Q8WTX3; Q96EW0" "Integrin-mediated cell adhesion" "Formation of the cornified envelope; Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "4" "0" "0.995" "0.948" "0.922" "1.024" "0.986" "1.017" "1.023" "1.007" "0.979" "1279.1" "1272.5" "1212.7" "1179.4" "1309.4" "1261.6" "1300.8" "1308.2" "1288.4" "1252.3" "" "" "" "" "" "" "" "" "" "" "1150.1" "1029.6" "1096.9" "1151.3" "1080.6" "1261.6" "974.0" "1155.5" "1152.9" "447.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790717896449630852" "False" "High" "IsMasterProtein" "Q9UPT8" "Zinc finger CCCH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=ZC3H4 PE=1 SV=3" "0.000" "False" "39.737" "12" "10" "11" "10" "1303" "140.2" "6.27" "48.49" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18044" "23211" "ENSG00000130749" "ZC3H4" "hsa:23211; Q9UPT8; Q9Y420" "" "" "0" "0" "0.954" "0.931" "0.934" "1.134" "1.008" "1.030" "0.959" "1.036" "0.731" "990.1" "944.7" "922.0" "925.0" "1122.5" "998.2" "1019.9" "949.8" "1025.9" "723.3" "" "" "" "" "" "" "" "" "" "" "890.2" "764.4" "834.0" "902.9" "926.3" "998.2" "763.7" "838.9" "918.0" "258.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5448927889689110920" "False" "High" "IsMasterProtein" "Q16539" "Mitogen-activated protein kinase 14 OS=Homo sapiens OX=9606 GN=MAPK14 PE=1 SV=3" "0.000" "False" "39.736" "31" "9" "14" "8" "360" "41.3" "5.78" "56.12" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1432" "ENSG00000112062" "MAPK14" "A6ZJ92; A8K6P4; B0LPH0; B5TY32; hsa:1432; O60776; Q13083; Q14084; Q16539; Q8TDX0" "Physiological and pathological hypertrophy of the heart; Angiogenesis; Energy metabolism; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac progenitor differentiation; Alpha 6 beta 4 signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Kit receptor signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; IL-4 signaling pathway; p38 MAPK signaling pathway; Oxidative stress response; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Regulatory circuits of the STAT3 signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Hepatitis B infection; Netrin-UNC5B signaling pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; Th17 cell differentiation pathway; GDNF signaling; Hippocampal synaptogenesis and neurogenesis; Comprehensive IL-17A signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; IL-19 signaling pathway; Interferon type I signaling pathways; T-cell receptor signaling pathway; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Monoamine transport; Toll-like receptor signaling pathway" "Neutrophil degranulation; Regulation of TP53 Activity through Phosphorylation; VEGFA-VEGFR2 Pathway; DSCAM interactions; RHO GTPases Activate NADPH Oxidases; Myogenesis; ERK/MAPK targets; Oxidative Stress Induced Senescence; ADP signalling through P2Y purinoceptor 1; NOD1/2 Signaling Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; KSRP (KHSRP) binds and destabilizes mRNA; Activation of the AP-1 family of transcription factors; Platelet sensitization by LDL; CD163 mediating an anti-inflammatory response" "92" "0" "1.049" "0.999" "1.011" "1.081" "1.024" "1.097" "1.039" "1.027" "1.600" "798.7" "838.1" "798.1" "807.7" "863.4" "817.6" "876.4" "829.9" "820.2" "1277.8" "" "" "" "" "" "" "" "" "" "" "718.1" "678.2" "721.9" "788.4" "712.5" "817.6" "656.2" "733.0" "733.9" "456.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3951709946097313123" "False" "High" "IsMasterProtein" "P78362" "SRSF protein kinase 2 OS=Homo sapiens OX=9606 GN=SRPK2 PE=1 SV=3" "0.000" "False" "39.678" "22" "12" "13" "9" "688" "77.5" "4.97" "42.43" "12" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6733" "ENSG00000135250" "SRPK2" "A8MVX2; hsa:6733; O75220; O75221; P78362; Q6NUL0; Q6V1X2; Q8IYQ3" "mRNA processing" "Maturation of nucleoprotein" "2" "0" "0.974" "0.885" "0.934" "1.002" "0.914" "0.976" "0.917" "0.897" "0.935" "397.0" "386.8" "351.5" "370.7" "397.6" "362.8" "387.5" "364.0" "356.0" "371.1" "" "" "" "" "" "" "" "" "" "" "357.0" "313.0" "317.9" "361.8" "328.1" "362.8" "290.1" "321.5" "318.6" "132.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4717651617297181896" "False" "High" "IsMasterProtein" "Q9UIC8" "Leucine carboxyl methyltransferase 1 OS=Homo sapiens OX=9606 GN=LCMT1 PE=1 SV=2" "0.000" "False" "39.673" "29" "11" "14" "11" "334" "38.4" "6.04" "44.69" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04072" "51451" "ENSG00000205629" "LCMT1" "A6NL89; A8K770; hsa:51451; Q53FC5; Q96CI5; Q9H6I9; Q9NTG4; Q9UIC8; Q9Y378" "" "Cyclin A/B1/B2 associated events during G2/M transition" "1" "0" "1.058" "1.026" "0.995" "1.021" "1.048" "1.003" "1.018" "1.035" "0.900" "1095.3" "1158.5" "1123.8" "1089.8" "1118.1" "1147.8" "1098.4" "1115.5" "1133.7" "985.6" "" "" "" "" "" "" "" "" "" "" "984.8" "937.4" "1016.5" "1063.8" "922.7" "1147.8" "822.5" "985.3" "1014.5" "351.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6960359147395003723" "False" "High" "IsMasterProtein" "P15498" "Proto-oncogene vav OS=Homo sapiens OX=9606 GN=VAV1 PE=1 SV=4" "0.000" "False" "39.671" "14" "12" "12" "12" "845" "98.3" "6.62" "43.40" "12" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00017, Pf00018, Pf00130, Pf00169, Pf00307, Pf00621" "7409" "ENSG00000141968" "VAV1" "B4DVK9; hsa:7409; M0QXX6; P15498; Q15860" "Prolactin signaling pathway; B cell receptor signaling pathway; Hematopoietic stem cell differentiation; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; EGF/EGFR signaling pathway; Modulators of TCR signaling and T cell activation; Regulation of actin cytoskeleton; Interferon type I signaling pathways; T-cell receptor signaling pathway" "RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; Potential therapeutics for SARS; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of signaling by CBL; GPVI-mediated activation cascade; Signaling by SCF-KIT; Azathioprine ADME; VEGFR2 mediated vascular permeability; Erythropoietin activates RAS; CD28 dependent Vav1 pathway" "38" "0" "0.989" "1.006" "0.935" "0.959" "0.950" "1.040" "0.846" "1.043" "7.667" "583.3" "576.6" "586.6" "545.4" "559.5" "554.0" "606.5" "493.4" "608.2" "4471.9" "" "" "" "" "" "" "" "" "" "" "524.4" "466.6" "530.6" "532.4" "461.7" "554.0" "454.1" "435.8" "544.2" "1596.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8295272483259113664" "False" "High" "IsMasterProtein" "Q9Y333" "U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens OX=9606 GN=LSM2 PE=1 SV=1" "0.000" "False" "39.669" "81" "7" "21" "7" "95" "10.8" "6.52" "84.33" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "57819" "ENSG00000172850; ENSG00000204392; ENSG00000224979; ENSG00000225998; ENSG00000231502; ENSG00000236826" "LSM2" "hsa:57819; Q6FGG1; Q9Y333" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "1.039" "1.034" "1.007" "1.068" "0.977" "1.106" "1.020" "1.059" "0.717" "1954.3" "2031.2" "2021.7" "1968.6" "2088.0" "1908.8" "2162.1" "1992.5" "2070.0" "1400.5" "" "" "" "" "" "" "" "" "" "" "1757.1" "1643.6" "1828.7" "1921.7" "1723.1" "1908.8" "1618.9" "1759.9" "1852.2" "499.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6438294564185077030" "False" "High" "IsMasterProtein" "Q9BPW8" "Protein NipSnap homolog 1 OS=Homo sapiens OX=9606 GN=NIPSNAP1 PE=1 SV=1" "0.000" "False" "39.639" "37" "10" "16" "8" "284" "33.3" "9.31" "55.03" "10" "other biological processes" "plasma membrane;other membranes;mitochondrion" "" "Pf07978" "8508" "ENSG00000184117" "NIPSNAP1" "B2RAY3; hsa:8508; O43800; Q9BPW8" "" "" "0" "2" "0.939" "1.003" "1.033" "0.941" "0.936" "0.961" "1.001" "1.012" "0.767" "1904.1" "1787.6" "1910.5" "1966.1" "1791.8" "1782.7" "1830.1" "1906.2" "1926.3" "1459.7" "" "" "" "" "" "" "" "" "" "" "1712.0" "1446.5" "1728.1" "1919.1" "1478.6" "1782.7" "1370.3" "1683.7" "1723.6" "521.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8256721828910616389" "False" "High" "IsMasterProtein" "P55196" "Afadin OS=Homo sapiens OX=9606 GN=AFDN PE=1 SV=3" "0.000" "False" "39.616" "8" "12" "13" "12" "1824" "206.7" "6.47" "44.15" "12" "cell adhesion;cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00498, Pf00595, Pf00788, Pf01843" "4301" "ENSG00000130396" "AFDN" "O75087; O75088; O75089; P55196; Q59FP0; Q5TIG6; Q5TIG7; Q9NSN7; Q9NU92" "VEGFA-VEGFR2 signaling; Ras signaling; 1q21.1 copy number variation syndrome" "" "3" "0" "1.007" "1.030" "0.974" "1.080" "1.028" "1.032" "1.001" "1.057" "1.020" "740.8" "746.2" "763.4" "721.5" "799.8" "761.4" "764.3" "741.2" "782.8" "755.4" "" "" "" "" "" "" "" "" "" "" "666.0" "603.8" "690.5" "704.3" "660.0" "761.4" "572.3" "654.7" "700.4" "269.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3443446084982214279" "False" "High" "IsMasterProtein" "Q9UN37" "Vacuolar protein sorting-associated protein 4A OS=Homo sapiens OX=9606 GN=VPS4A PE=1 SV=1" "0.000" "False" "39.597" "26" "12" "20" "7" "437" "48.9" "7.80" "48.44" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00004, Pf04212, Pf09336, Pf17862" "27183" "ENSG00000132612" "VPS4A" "B2RCB7; hsa:27183; Q8TF07; Q9UI03; Q9UN37; Q9Y582" "Ebola virus infection in host; Ciliary landscape" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III" "6" "0" "1.007" "1.041" "0.962" "0.986" "1.025" "0.979" "1.001" "1.134" "1.141" "553.7" "557.6" "576.6" "532.9" "546.0" "567.5" "542.3" "554.1" "628.2" "632.0" "" "" "" "" "" "" "" "" "" "" "497.8" "451.2" "521.5" "520.2" "450.5" "567.5" "406.0" "489.4" "562.1" "225.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8417235359346522376" "False" "High" "IsMasterProtein" "Q9NR12" "PDZ and LIM domain protein 7 OS=Homo sapiens OX=9606 GN=PDLIM7 PE=1 SV=1" "0.000" "False" "39.545" "21" "9" "14" "9" "457" "49.8" "8.41" "49.02" "9" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "9260" "ENSG00000196923" "PDLIM7" "hsa:9260; Q14250; Q5XG82; Q6NVZ5; Q96C91; Q9BXB8; Q9BXB9; Q9NR12" "Ebstein-Barr virus LMP1 signaling; GDNF signaling; 5q35 copy number variation" "RET signaling" "4" "0" "1.006" "0.970" "0.979" "1.102" "1.124" "1.077" "0.996" "1.044" "1.251" "653.0" "656.7" "633.3" "639.1" "719.7" "733.8" "703.2" "650.3" "681.5" "817.1" "" "" "" "" "" "" "" "" "" "" "587.1" "531.4" "572.9" "623.8" "593.9" "733.8" "526.6" "574.4" "609.8" "291.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8032789585989089755" "False" "High" "IsMasterProtein" "Q9BYV9" "Transcription regulator protein BACH2 OS=Homo sapiens OX=9606 GN=BACH2 PE=1 SV=1" "0.000" "False" "39.538" "17" "13" "13" "13" "841" "92.5" "5.10" "51.96" "13" "transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "60468" "ENSG00000112182" "BACH2" "E1P518; hsa:60468; Q59H70; Q5T793; Q9BYV9; Q9NTS5" "Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "1" "0" "1.077" "0.963" "1.054" "1.104" "1.065" "1.158" "1.148" "0.950" "1.260" "729.1" "785.2" "702.3" "768.7" "805.1" "776.6" "844.7" "837.3" "693.0" "918.8" "" "" "" "" "" "" "" "" "" "" "655.6" "635.4" "635.3" "750.3" "664.4" "776.6" "632.5" "739.6" "620.1" "328.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4429006779143257910" "False" "High" "IsMasterProtein" "Q14320" "Protein FAM50A OS=Homo sapiens OX=9606 GN=FAM50A PE=1 SV=2" "0.000" "False" "39.489" "30" "10" "17" "10" "339" "40.2" "6.83" "58.76" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf04921" "9130" "ENSG00000071859" "FAM50A" "A8KAQ4; B2R997; hsa:9130; Q14320; Q5HY37; Q6PJH5" "" "mRNA Splicing - Major Pathway" "1" "0" "0.963" "0.991" "0.984" "1.015" "0.975" "1.063" "1.031" "0.979" "1.076" "1447.5" "1393.9" "1434.2" "1424.0" "1469.1" "1411.7" "1539.2" "1492.9" "1416.9" "1558.1" "" "" "" "" "" "" "" "" "" "" "1301.4" "1127.9" "1297.3" "1390.1" "1212.4" "1411.7" "1152.5" "1318.6" "1267.8" "556.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8260092317082084293" "False" "High" "IsMasterProtein" "Q13362" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP2R5C PE=1 SV=3" "0.000" "False" "39.456" "22" "11" "16" "8" "524" "61.0" "6.87" "58.02" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf01603" "5527" "ENSG00000078304" "PPP2R5C" "B4DYJ8; B5BUA5; F5GWP3; hsa:5527; Q13362; Q14391; Q15060; Q15174; Q6ZN33" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Wnt signaling pathway and pluripotency; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome; DNA damage response (only ATM dependent)" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of TP53 Degradation; RAF activation; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "29" "0" "1.069" "1.027" "0.990" "1.004" "0.967" "1.037" "1.074" "0.963" "1.105" "775.5" "829.2" "796.2" "767.8" "778.6" "750.1" "804.5" "833.3" "746.8" "857.3" "" "" "" "" "" "" "" "" "" "" "697.3" "670.9" "720.2" "749.5" "642.5" "750.1" "602.4" "736.0" "668.2" "306.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-94552620576090045" "False" "High" "IsMasterProtein" "Q8IYM9" "E3 ubiquitin-protein ligase TRIM22 OS=Homo sapiens OX=9606 GN=TRIM22 PE=1 SV=1" "0.000" "False" "39.366" "19" "11" "16" "11" "498" "56.9" "7.72" "47.60" "11" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13445" "10346" "ENSG00000132274" "TRIM22" "hsa:10346; Q05CQ0; Q15521; Q8IYM9" "" "Interferon gamma signaling" "1" "0" "1.031" "1.072" "1.014" "1.027" "1.047" "1.056" "0.959" "0.981" "1.056" "1345.7" "1387.4" "1443.1" "1364.3" "1381.6" "1408.7" "1421.5" "1290.9" "1319.5" "1420.4" "" "" "" "" "" "" "" "" "" "" "1209.9" "1122.6" "1305.3" "1331.8" "1140.1" "1408.7" "1064.4" "1140.2" "1180.7" "507.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7289415820017297402" "False" "High" "IsMasterProtein" "P82675" "Small ribosomal subunit protein uS5m OS=Homo sapiens OX=9606 GN=MRPS5 PE=1 SV=2" "0.000" "False" "39.362" "25" "12" "16" "12" "430" "48.0" "9.92" "53.33" "12" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00333, Pf03719, Pf21251" "64969" "ENSG00000144029" "MRPS5" "hsa:64969; P82675; Q4ZFY5; Q96LJ6; Q9BWI4; Q9BYC4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.917" "0.868" "0.907" "0.888" "0.850" "0.951" "0.790" "0.869" "1.259" "1309.9" "1200.9" "1137.0" "1188.1" "1162.6" "1113.2" "1245.1" "1035.1" "1137.7" "1648.9" "" "" "" "" "" "" "" "" "" "" "1177.7" "971.7" "1028.4" "1159.8" "959.4" "1113.2" "932.3" "914.3" "1018.0" "588.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7804593392060362224" "False" "High" "IsMasterProtein" "P14324" "Farnesyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=FDPS PE=1 SV=4" "0.000" "False" "39.332" "17" "6" "14" "6" "419" "48.2" "6.15" "45.58" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00348" "2224" "ENSG00000160752" "FDPS" "D3DV91; E9PCI9; hsa:2224; P14324; Q96G29" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "9" "0" "0.879" "0.919" "1.042" "0.791" "0.848" "0.938" "0.745" "0.790" "2.422" "1143.9" "1005.7" "1051.2" "1191.8" "905.1" "969.9" "1072.4" "852.2" "903.4" "2770.6" "" "" "" "" "" "" "" "" "" "" "1028.5" "813.8" "950.9" "1163.4" "746.9" "969.9" "803.0" "752.7" "808.3" "989.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "385044699666679526" "False" "High" "IsMasterProtein" "P49756" "RNA-binding protein 25 OS=Homo sapiens OX=9606 GN=RBM25 PE=1 SV=3" "0.000" "False" "39.326" "16" "12" "16" "12" "843" "100.1" "6.32" "47.87" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf01480" "58517" "ENSG00000119707" "RBM25" "A0PJL9; B2RNA8; B3KT03; hsa:58517; P49756; Q2TA72; Q5XJ17; Q6P665; Q9H6A1; Q9UEQ5; Q9UIE9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.051" "1.007" "0.951" "1.008" "1.090" "1.099" "1.029" "1.055" "1.006" "581.8" "611.6" "586.0" "553.5" "586.2" "634.4" "639.5" "598.5" "613.9" "585.4" "" "" "" "" "" "" "" "" "" "" "523.1" "494.8" "530.1" "540.3" "483.7" "634.4" "478.9" "528.6" "549.3" "209.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587567595163417034" "False" "High" "IsMasterProtein" "Q9UIQ6" "Leucyl-cystinyl aminopeptidase OS=Homo sapiens OX=9606 GN=LNPEP PE=1 SV=3" "0.000" "False" "39.295" "13" "10" "11" "10" "1025" "117.3" "5.73" "37.73" "10" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "4012" "ENSG00000113441" "LNPEP" "hsa:4012; O00769; Q15145; Q59H76; Q9TNQ2; Q9TNQ3; Q9UIQ6; Q9UIQ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Endosomal/Vacuolar pathway" "3" "0" "0.983" "0.897" "0.979" "0.946" "0.929" "1.025" "0.943" "0.867" "0.888" "574.5" "564.9" "515.5" "562.6" "543.7" "533.7" "588.8" "541.7" "498.0" "510.1" "" "" "" "" "" "" "" "" "" "" "516.6" "457.1" "466.3" "549.2" "448.7" "533.7" "440.9" "478.5" "445.6" "182.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3531343313582380268" "False" "High" "IsMasterProtein" "P42338" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1" "0.000" "False" "39.293" "9" "10" "13" "9" "1070" "122.7" "7.09" "48.53" "10" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5291" "ENSG00000051382" "PIK3CB" "D3DNF0; hsa:5291; P42338; Q24JU2" "AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; Focal adhesion; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Downstream TCR signaling; Nephrin family interactions; RET signaling; Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; VEGFA-VEGFR2 Pathway; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Signaling by CSF1 (M-CSF) in myeloid cells" "74" "0" "1.011" "1.007" "0.938" "0.975" "0.971" "1.031" "0.951" "0.953" "0.977" "1106.3" "1118.0" "1114.2" "1038.0" "1078.7" "1074.5" "1140.4" "1051.9" "1054.8" "1080.4" "" "" "" "" "" "" "" "" "" "" "994.7" "904.6" "1007.8" "1013.2" "890.2" "1074.5" "853.9" "929.1" "943.8" "385.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-902532758451743562" "False" "High" "IsMasterProtein" "Q96B26" "Exosome complex component RRP43 OS=Homo sapiens OX=9606 GN=EXOSC8 PE=1 SV=1" "0.000" "False" "39.279" "35" "7" "15" "7" "276" "30.0" "5.30" "62.54" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "11340" "ENSG00000120699" "EXOSC8" "hsa:11340; O43480; Q5TBA5; Q96B26" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "0.971" "1.080" "1.019" "1.037" "1.026" "0.989" "1.002" "1.077" "0.644" "1467.2" "1425.2" "1584.7" "1494.5" "1520.7" "1505.8" "1450.9" "1470.2" "1579.7" "944.2" "" "" "" "" "" "" "" "" "" "" "1319.1" "1153.2" "1433.4" "1458.8" "1254.9" "1505.8" "1086.4" "1298.6" "1413.5" "337.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9065508386869284325" "False" "High" "IsMasterProtein" "Q9Y2L5" "Trafficking protein particle complex subunit 8 OS=Homo sapiens OX=9606 GN=TRAPPC8 PE=1 SV=2" "0.000" "False" "39.267" "8" "11" "14" "11" "1435" "160.9" "6.87" "44.89" "11" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf12739" "22878" "ENSG00000153339" "TRAPPC8" "A0JP15; B3KME5; hsa:22878; Q9H0L2; Q9Y2L5" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.096" "1.014" "1.070" "1.053" "0.945" "1.011" "0.996" "1.006" "1.273" "666.4" "730.6" "675.6" "713.2" "701.8" "629.6" "673.5" "663.5" "670.6" "848.0" "" "" "" "" "" "" "" "" "" "" "599.1" "591.1" "611.1" "696.1" "579.1" "629.6" "504.3" "586.1" "600.0" "302.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4832676921386861974" "False" "High" "IsMasterProtein" "Q8WW33" "Gametocyte-specific factor 1 OS=Homo sapiens OX=9606 GN=GTSF1 PE=1 SV=2" "0.000" "False" "39.212" "51" "8" "20" "8" "167" "19.3" "6.51" "76.38" "8" "other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05253" "121355" "ENSG00000170627" "GTSF1" "B3KQ60; hsa:121355; Q0VGM4; Q8N778; Q8WW33" "" "" "0" "0" "1.029" "1.033" "0.948" "1.054" "1.074" "1.013" "1.065" "1.054" "0.884" "1221.1" "1256.6" "1261.8" "1157.8" "1287.3" "1311.6" "1237.1" "1300.9" "1286.4" "1079.4" "" "" "" "" "" "" "" "" "" "" "1097.8" "1016.8" "1141.3" "1130.2" "1062.3" "1311.6" "926.3" "1149.0" "1151.1" "385.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802113826893248650" "False" "High" "IsMasterProtein" "P07108" "Acyl-CoA-binding protein OS=Homo sapiens OX=9606 GN=DBI PE=1 SV=2" "0.000" "False" "39.180" "51" "3" "21" "3" "87" "10.0" "6.57" "103.86" "3" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00887" "1622" "ENSG00000155368" "DBI" "B8ZWD2; B8ZWD6; B8ZWD7; hsa:1622; P07108; P08869; Q4VWZ6; Q53SQ7; Q6IB48; Q9UCI8" "Sterol regulatory element-binding proteins (SREBP) signaling; PPAR-alpha pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Fatty acid transporters" "Mitochondrial Fatty Acid Beta-Oxidation" "6" "0" "0.942" "0.929" "0.959" "0.919" "0.881" "0.818" "0.957" "0.882" "0.730" "2987.3" "2815.3" "2774.8" "2863.4" "2746.0" "2632.0" "2442.9" "2858.5" "2635.3" "2180.5" "" "" "" "" "" "" "" "" "" "" "2685.9" "2278.0" "2509.9" "2795.1" "2266.0" "2632.0" "1829.2" "2524.9" "2358.0" "778.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3568941862227660384" "False" "High" "IsMasterProtein" "Q9NVP2" "Histone chaperone ASF1B OS=Homo sapiens OX=9606 GN=ASF1B PE=1 SV=1" "0.000" "False" "39.156" "53" "6" "10" "5" "202" "22.4" "4.56" "48.55" "6" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04729" "55723" "ENSG00000105011; ENSG00000288210" "ASF1B" "hsa:55723; Q53G51; Q9NVP2; Q9NVZ0" "" "" "0" "1" "1.053" "1.184" "0.999" "1.049" "1.300" "0.990" "1.004" "1.196" "1.314" "753.9" "793.6" "892.5" "753.4" "791.2" "980.1" "746.4" "757.3" "902.0" "990.7" "" "" "" "" "" "" "" "" "" "" "677.8" "642.1" "807.3" "735.4" "652.9" "980.1" "558.9" "668.9" "807.1" "353.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8315542899134672596" "False" "High" "IsMasterProtein" "O94804" "Serine/threonine-protein kinase 10 OS=Homo sapiens OX=9606 GN=STK10 PE=1 SV=1" "0.000" "False" "39.124" "13" "11" "12" "11" "968" "112.1" "6.95" "39.73" "11" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12474" "6793" "ENSG00000072786" "STK10" "A6ND35; B2R8F5; B3KMY1; hsa:6793; O94804; Q6NSK0; Q9UIW4" "" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Neutrophil degranulation" "4" "0" "0.976" "0.996" "1.008" "0.908" "1.008" "1.001" "0.874" "0.965" "5.689" "1162.1" "1134.2" "1157.2" "1171.9" "1055.6" "1170.9" "1162.9" "1015.2" "1121.1" "6611.5" "" "" "" "" "" "" "" "" "" "" "1044.8" "917.8" "1046.7" "1144.0" "871.1" "1170.9" "870.8" "896.7" "1003.1" "2360.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1008427851520544832" "False" "High" "IsMasterProtein" "Q4KMP7" "TBC1 domain family member 10B OS=Homo sapiens OX=9606 GN=TBC1D10B PE=1 SV=3" "0.000" "False" "39.053" "18" "9" "19" "9" "808" "87.1" "9.19" "70.19" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "26000" "ENSG00000169221" "TBC1D10B" "B9A6L0; hsa:26000; Q4KMP7; Q6IN54; Q6P530; Q71RG7; Q86VC5; Q9H8Z2; Q9NUN6; Q9UFP2" "" "TBC/RABGAPs" "1" "0" "0.920" "1.126" "0.754" "0.885" "0.931" "0.869" "0.876" "0.849" "0.768" "945.8" "870.3" "1065.2" "712.7" "836.7" "880.6" "821.5" "828.7" "802.6" "726.3" "" "" "" "" "" "" "" "" "" "" "850.4" "704.2" "963.5" "695.7" "690.5" "880.6" "615.1" "732.0" "718.2" "259.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549741875275556482" "False" "High" "IsMasterProtein" "Q99627" "COP9 signalosome complex subunit 8 OS=Homo sapiens OX=9606 GN=COPS8 PE=1 SV=1" "0.000" "False" "39.050" "40" "5" "16" "5" "209" "23.2" "5.38" "74.75" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10075" "10920" "ENSG00000198612" "COPS8" "A8K1H6; hsa:10920; Q53QS9; Q99627" "Ciliary landscape; 2q37 copy number variation syndrome" "Neddylation; DNA Damage Recognition in GG-NER; Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex" "6" "0" "1.115" "1.088" "1.033" "1.133" "1.077" "1.113" "1.115" "1.106" "0.904" "1076.2" "1199.9" "1171.2" "1111.9" "1219.0" "1158.6" "1197.8" "1199.9" "1190.7" "972.4" "" "" "" "" "" "" "" "" "" "" "967.6" "971.0" "1059.4" "1085.4" "1005.9" "1158.6" "896.9" "1059.8" "1065.4" "347.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7873771796286241695" "False" "High" "IsMasterProtein" "A6NHL2" "Tubulin alpha chain-like 3 OS=Homo sapiens OX=9606 GN=TUBAL3 PE=1 SV=2" "0.000" "False" "39.048" "10" "5" "37" "1" "446" "49.9" "6.05" "125.95" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "79861" "ENSG00000178462" "TUBAL3" "A6NHL2; B4DKL2; hsa:79861; Q4QQJ5; Q9H6Z0" "Alzheimer's disease and miRNA effects; Pathogenic Escherichia coli infection; Parkin-ubiquitin proteasomal system pathway; Alzheimer's disease" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; Separation of Sister Chromatids; The role of GTSE1 in G2/M progression after G2 checkpoint; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane; Gap junction assembly; MHC class II antigen presentation; Resolution of Sister Chromatid Cohesion; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; Formation of tubulin folding intermediates by CCT/TriC; Post-chaperonin tubulin folding pathway; Cilium Assembly; RHO GTPases activate IQGAPs; RHO GTPases Activate Formins; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Carboxyterminal post-translational modifications of tubulin; HCMV Early Events; Assembly and cell surface presentation of NMDA receptors; Activation of AMPK downstream of NMDARs; Aggrephagy; EML4 and NUDC in mitotic spindle formation; Sealing of the nuclear envelope (NE) by ESCRT-III; Kinesins; PKR-mediated signaling" "32" "0" "1.028" "0.965" "1.014" "1.092" "0.882" "1.030" "0.925" "0.957" "0.887" "802.2" "824.6" "774.2" "813.2" "875.8" "707.4" "826.0" "741.9" "767.4" "711.5" "" "" "" "" "" "" "" "" "" "" "721.2" "667.2" "700.3" "793.8" "722.7" "707.4" "618.5" "655.3" "686.6" "254.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7969393992682693722" "False" "High" "IsMasterProtein" "Q9NUJ1" "Palmitoyl-protein thioesterase ABHD10, mitochondrial OS=Homo sapiens OX=9606 GN=ABHD10 PE=1 SV=1" "0.000" "False" "39.029" "34" "9" "16" "9" "306" "33.9" "8.57" "54.39" "9" "protein metabolism;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00561" "55347" "ENSG00000144827" "ABHD10" "B7Z6A8; C9IZX5; D3DN63; hsa:55347; Q8TCF9; Q9NUJ1" "" "Glucuronidation" "1" "0" "1.011" "1.030" "0.985" "1.077" "0.996" "1.094" "1.045" "1.093" "0.830" "1226.9" "1240.0" "1263.9" "1208.4" "1321.0" "1222.0" "1342.6" "1281.7" "1340.7" "1018.7" "" "" "" "" "" "" "" "" "" "" "1103.1" "1003.4" "1143.2" "1179.6" "1090.1" "1222.0" "1005.3" "1132.1" "1199.6" "363.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1344142120960836563" "False" "High" "IsMasterProtein" "Q9BWS9" "Chitinase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CHID1 PE=1 SV=1" "0.000" "False" "38.961" "26" "10" "15" "10" "393" "44.9" "8.63" "49.79" "10" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00704" "66005" "ENSG00000177830" "CHID1" "B3KWB0; hsa:66005; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BWS9; Q9BY52" "" "Platelet degranulation" "1" "0" "0.975" "0.988" "0.989" "1.011" "1.053" "0.988" "0.988" "1.005" "1.054" "969.2" "944.7" "957.7" "958.5" "979.6" "1020.4" "957.8" "957.4" "974.6" "1021.9" "" "" "" "" "" "" "" "" "" "" "871.4" "764.4" "866.3" "935.7" "808.4" "1020.4" "717.2" "845.7" "872.0" "364.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-77584884133553683" "False" "High" "IsMasterProtein" "Q9UMY4" "Sorting nexin-12 OS=Homo sapiens OX=9606 GN=SNX12 PE=1 SV=4" "0.000" "False" "38.952" "49" "9" "19" "7" "162" "18.9" "8.44" "64.16" "9" "transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29934" "ENSG00000147164" "SNX12" "F8W8K5; hsa:29934; Q8WUG9; Q9UMY4" "" "" "0" "2" "0.996" "1.015" "0.987" "1.051" "0.956" "0.988" "1.066" "1.003" "1.299" "1787.4" "1780.4" "1813.5" "1764.6" "1877.7" "1708.9" "1766.5" "1905.0" "1793.3" "2322.1" "" "" "" "" "" "" "" "" "" "" "1607.0" "1440.7" "1640.4" "1722.5" "1549.5" "1708.9" "1322.7" "1682.6" "1604.6" "828.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8811809090486028216" "False" "High" "IsMasterProtein" "Q6QNY0" "Biogenesis of lysosome-related organelles complex 1 subunit 3 OS=Homo sapiens OX=9606 GN=BLOC1S3 PE=1 SV=1" "0.000" "False" "38.936" "61" "9" "11" "9" "202" "21.2" "5.15" "48.89" "9" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;ER/Golgi;other cell component" "transporter activity" "Pf15753" "388552" "ENSG00000189114" "BLOC1S3" "B2RXB8; hsa:388552; Q6QNY0" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.018" "0.989" "0.973" "1.065" "1.056" "1.012" "1.053" "0.967" "0.923" "473.2" "481.6" "467.8" "460.5" "504.0" "499.8" "478.7" "498.4" "457.6" "436.8" "" "" "" "" "" "" "" "" "" "" "425.5" "389.7" "423.1" "449.5" "415.9" "499.8" "358.5" "440.2" "409.4" "155.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3677224009341935597" "False" "High" "IsMasterProtein" "P48729" "Casein kinase I isoform alpha OS=Homo sapiens OX=9606 GN=CSNK1A1 PE=1 SV=2" "0.000" "False" "38.912" "29" "8" "12" "8" "337" "38.9" "9.57" "51.96" "8" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1452" "ENSG00000113712" "CSNK1A1" "D3DQG0; D3DQG1; hsa:1452; P48729; Q4JJA0; Q5U046; Q5U047; Q6FGA2; Q71TU5; Q96HD2; Q9UDK3" "Alzheimer's disease and miRNA effects; T cell receptor and co-stimulatory signaling; Complement system; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Chromosomal and microsatellite instability in colorectal cancer ; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Alzheimer's disease; DYRK1A involvement regarding cell proliferation in brain development" "Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Activation of SMO; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Maturation of nucleoprotein" "32" "0" "1.023" "1.075" "0.934" "0.982" "1.102" "0.976" "0.953" "1.005" "1.169" "1063.6" "1088.0" "1142.9" "993.9" "1044.8" "1172.2" "1038.2" "1013.6" "1068.7" "1243.2" "" "" "" "" "" "" "" "" "" "" "956.3" "880.4" "1033.8" "970.2" "862.2" "1172.2" "777.4" "895.2" "956.3" "443.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6639760008816947129" "False" "High" "IsMasterProtein" "Q6ZUM4" "Rho GTPase-activating protein 27 OS=Homo sapiens OX=9606 GN=ARHGAP27 PE=1 SV=3" "0.000" "False" "38.806" "16" "13" "14" "13" "889" "98.3" "5.59" "44.91" "13" "transport;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00397, Pf00620" "201176" "ENSG00000159314; ENSG00000276836; ENSG00000276907" "ARHGAP27" "A4FU35; A8K3N5; C9JTF3; hsa:201176; Q494U0; Q6NWZ8; Q6ZUM4; Q8WY58" "" "CDC42 GTPase cycle; RAC1 GTPase cycle" "2" "0" "1.017" "1.084" "0.965" "1.017" "1.063" "0.971" "0.998" "1.002" "0.929" "724.5" "737.1" "785.3" "699.4" "736.9" "770.3" "703.5" "722.8" "725.9" "672.8" "" "" "" "" "" "" "" "" "" "" "651.4" "596.4" "710.3" "682.7" "608.1" "770.3" "526.8" "638.4" "649.5" "240.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2097918301010195378" "False" "High" "IsMasterProtein" "P28715" "DNA excision repair protein ERCC-5 OS=Homo sapiens OX=9606 GN=ERCC5 PE=1 SV=3" "0.000" "False" "38.785" "10" "10" "12" "10" "1186" "133.0" "5.22" "40.68" "10" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00752, Pf00867" "2073" "ENSG00000134899" "ERCC5" "A6NGT4; hsa:2073; P28715; Q5JUS4; Q5JUS5; Q7Z2V3; Q8IZL6; Q8N1B7; Q9HD59; Q9HD60" "Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; 10q11.21q11.23 copy number variation syndrome" "Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "7" "0" "1.102" "1.003" "1.011" "1.199" "1.075" "1.202" "1.016" "0.951" "1.088" "250.6" "276.2" "251.3" "253.3" "300.4" "269.3" "301.2" "254.6" "238.3" "272.6" "" "" "" "" "" "" "" "" "" "" "225.3" "223.5" "227.3" "247.2" "247.9" "269.3" "225.5" "224.9" "213.2" "97.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5155041473924721713" "False" "High" "IsMasterProtein" "P48454" "Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PPP3CC PE=1 SV=3" "0.000" "False" "38.774" "22" "9" "13" "7" "512" "58.1" "6.98" "49.18" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00149" "5533" "ENSG00000120910" "PPP3CC" "B4DRT5; hsa:5533; P48454; Q9BSS6; Q9H4M5" "Energy metabolism; Alzheimer's disease and miRNA effects; Amyotrophic lateral sclerosis (ALS); Initiation of transcription and translation elongation at the HIV-1 LTR; G protein signaling pathways; MAPK signaling pathway; Wnt signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "DARPP-32 events; Activation of BAD and translocation to mitochondria" "11" "0" "1.008" "0.934" "0.949" "1.016" "0.967" "0.989" "0.982" "0.967" "0.900" "781.9" "788.4" "730.5" "742.0" "794.3" "756.4" "772.9" "767.8" "756.2" "703.5" "" "" "" "" "" "" "" "" "" "" "703.0" "637.9" "660.7" "724.3" "655.5" "756.4" "578.7" "678.1" "676.6" "251.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "798152879982526566" "False" "High" "IsMasterProtein" "Q8WWH5" "Pseudouridylate synthase TRUB1 OS=Homo sapiens OX=9606 GN=TRUB1 PE=1 SV=1" "0.000" "False" "38.710" "33" "10" "13" "10" "349" "37.2" "8.25" "48.85" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01509" "142940" "ENSG00000165832" "TRUB1" "B2R716; hsa:142940; Q53ES2; Q8WWH5" "" "" "0" "0" "1.059" "0.982" "0.975" "1.097" "0.998" "1.124" "1.073" "1.017" "1.016" "536.1" "567.5" "526.4" "522.9" "588.1" "535.3" "602.5" "575.2" "545.0" "544.5" "" "" "" "" "" "" "" "" "" "" "482.0" "459.2" "476.2" "510.4" "485.3" "535.3" "451.2" "508.0" "487.7" "194.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225336690214534054" "False" "High" "IsMasterProtein" "O43768" "Alpha-endosulfine OS=Homo sapiens OX=9606 GN=ENSA PE=1 SV=1" "0.000" "False" "38.661" "54" "6" "19" "5" "121" "13.4" "7.24" "70.91" "6" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "2029" "ENSG00000143420" "ENSA" "A8K1Z9; E9PB69; hsa:2029; O43768; Q5T5H2; Q68D48; Q6FHW0; Q6IAM4; Q6NUL2; Q6VUC6; Q6VUC7; Q6VUC8; Q6VUC9; Q6VUD0; Q6VUD1; Q9NRZ0" "" "MASTL Facilitates Mitotic Progression" "1" "2" "0.936" "0.913" "1.045" "0.878" "0.900" "0.905" "0.962" "0.911" "0.722" "2745.1" "2569.8" "2506.2" "2867.9" "2409.3" "2470.0" "2485.5" "2641.1" "2500.0" "1982.0" "" "" "" "" "" "" "" "" "" "" "2468.1" "2079.4" "2267.0" "2799.4" "1988.2" "2470.0" "1861.1" "2332.8" "2237.0" "707.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2347983332977388865" "False" "High" "IsMasterProtein" "Q9H900" "Protein zwilch homolog OS=Homo sapiens OX=9606 GN=ZWILCH PE=1 SV=2" "0.000" "False" "38.660" "20" "10" "13" "10" "591" "67.2" "6.27" "48.51" "10" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf09817" "55055" "ENSG00000174442" "ZWILCH" "B3KVB8; hsa:55055; Q6N049; Q8N404; Q96SY7; Q9H900; Q9NWG7" "" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.054" "1.052" "0.984" "1.044" "0.996" "1.031" "1.024" "1.058" "1.133" "1171.3" "1234.5" "1232.6" "1152.3" "1223.0" "1166.3" "1208.0" "1199.4" "1239.3" "1326.8" "" "" "" "" "" "" "" "" "" "" "1053.1" "998.9" "1114.9" "1124.8" "1009.2" "1166.3" "904.5" "1059.4" "1108.9" "473.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2064398730154585057" "False" "High" "IsMasterProtein" "Q15061" "WD repeat-containing protein 43 OS=Homo sapiens OX=9606 GN=WDR43 PE=1 SV=3" "0.000" "False" "38.644" "17" "12" "20" "12" "677" "74.8" "5.57" "56.54" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04003" "23160" "ENSG00000163811" "WDR43" "hsa:23160; Q15061; Q15395; Q92577" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.054" "1.306" "0.926" "1.055" "1.457" "0.917" "1.068" "1.329" "0.504" "1305.1" "1375.7" "1704.7" "1208.8" "1376.6" "1900.9" "1196.2" "1393.6" "1734.1" "657.4" "" "" "" "" "" "" "" "" "" "" "1173.4" "1113.1" "1541.9" "1179.9" "1136.0" "1900.9" "895.7" "1230.9" "1551.7" "234.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4265990204774033592" "False" "High" "IsMasterProtein" "O75175" "CCR4-NOT transcription complex subunit 3 OS=Homo sapiens OX=9606 GN=CNOT3 PE=1 SV=1" "0.000" "False" "38.644" "14" "11" "17" "11" "753" "81.8" "6.20" "56.61" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04065, Pf04153" "4849" "ENSG00000088038; ENSG00000273943; ENSG00000274176; ENSG00000274616; ENSG00000274941; ENSG00000275979; ENSG00000276082; ENSG00000277114; ENSG00000277600; ENSG00000277615" "CNOT3" "hsa:4849; O75175; Q9NZN7; Q9UF76" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.033" "1.026" "1.047" "1.049" "1.012" "1.076" "0.997" "0.999" "1.034" "1652.0" "1706.8" "1695.8" "1730.0" "1732.6" "1671.4" "1778.1" "1647.3" "1650.9" "1708.7" "" "" "" "" "" "" "" "" "" "" "1485.4" "1381.1" "1533.9" "1688.7" "1429.8" "1671.4" "1331.4" "1455.0" "1477.2" "610.0" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8454971752249747449" "False" "High" "IsMasterProtein" "Q9BSD7" "Cancer-related nucleoside-triphosphatase OS=Homo sapiens OX=9606 GN=NTPCR PE=1 SV=1" "0.000" "False" "38.601" "53" "8" "15" "8" "190" "20.7" "9.54" "55.45" "8" "" "" "other molecular function" "Pf03266" "84284" "ENSG00000135778" "NTPCR" "hsa:84284; Q9BSD7" "" "" "0" "0" "1.045" "1.016" "0.947" "1.065" "1.043" "1.006" "1.008" "1.054" "1.026" "520.2" "543.6" "528.5" "492.7" "554.0" "542.4" "523.4" "524.3" "548.3" "533.5" "" "" "" "" "" "" "" "" "" "" "467.7" "439.9" "478.1" "480.9" "457.1" "542.4" "391.9" "463.1" "490.6" "190.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2971731893176673056" "False" "High" "IsMasterProtein" "O15305" "Phosphomannomutase 2 OS=Homo sapiens OX=9606 GN=PMM2 PE=1 SV=1" "0.000" "False" "38.591" "29" "7" "19" "7" "246" "28.1" "6.77" "56.01" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03332" "5373" "ENSG00000140650" "PMM2" "A8K672; B7Z6R0; D3DUF3; hsa:5373; O15305" "Nephrotic syndrome; N-glycan biosynthesis; Primary ovarian insufficiency" "Defective PMM2 causes PMM2-CDG; Synthesis of GDP-mannose" "5" "0" "1.010" "0.940" "0.987" "1.035" "0.926" "1.019" "1.043" "0.996" "0.778" "1654.1" "1670.3" "1554.2" "1632.7" "1712.1" "1532.1" "1686.0" "1725.3" "1648.2" "1286.5" "" "" "" "" "" "" "" "" "" "" "1487.2" "1351.6" "1405.8" "1593.8" "1412.9" "1532.1" "1262.4" "1523.9" "1474.8" "459.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9042131036706186365" "False" "High" "IsMasterProtein" "Q13485" "Mothers against decapentaplegic homolog 4 OS=Homo sapiens OX=9606 GN=SMAD4 PE=1 SV=1" "0.000" "False" "38.577" "25" "13" "18" "13" "552" "60.4" "6.99" "63.15" "13" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4089" "ENSG00000141646" "SMAD4" "A8K405; hsa:4089; Q13485" "Androgen receptor signaling pathway; Bone morphogenic protein signaling and regulation; Heart development; Cell cycle; Endoderm differentiation; Mesodermal commitment pathway; Ectoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hepatitis B infection; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling; Progeria-associated lipodystrophy; Clock-controlled autophagy in bone metabolism; Rubinstein-Taybi syndrome 1; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Signaling by BMP; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Cardiogenesis; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Transcriptional regulation of pluripotent stem cells; RUNX3 regulates BCL2L11 (BIM) transcription; RUNX2 regulates bone development; Signaling by Activin; TGF-beta receptor signaling activates SMADs; RUNX3 regulates CDKN1A transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "53" "0" "0.985" "0.984" "1.001" "0.976" "1.017" "0.974" "0.995" "1.023" "0.866" "1430.9" "1409.7" "1408.2" "1432.2" "1396.2" "1454.8" "1393.1" "1424.0" "1464.6" "1239.3" "" "" "" "" "" "" "" "" "" "" "1286.6" "1140.7" "1273.8" "1398.0" "1152.2" "1454.8" "1043.1" "1257.8" "1310.5" "442.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7384087443166083849" "False" "High" "IsMasterProtein" "O14562" "Ubiquitin domain-containing protein UBFD1 OS=Homo sapiens OX=9606 GN=UBFD1 PE=1 SV=2" "0.000" "False" "38.541" "27" "7" "16" "7" "309" "33.4" "5.77" "59.48" "7" "" "" "" "Pf00240" "56061" "ENSG00000103353" "UBFD1" "A8MW58; D3DWF2; hsa:56061; O14562" "" "" "0" "0" "0.946" "0.998" "0.996" "1.013" "1.040" "0.978" "1.031" "1.059" "0.919" "1236.5" "1169.7" "1234.0" "1232.0" "1252.1" "1286.1" "1208.9" "1274.6" "1309.7" "1135.9" "" "" "" "" "" "" "" "" "" "" "1111.7" "946.5" "1116.2" "1202.6" "1033.3" "1286.1" "905.2" "1125.8" "1171.9" "405.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8760192209186557782" "False" "High" "IsMasterProtein" "Q8NCA5" "Protein FAM98A OS=Homo sapiens OX=9606 GN=FAM98A PE=1 SV=2" "0.000" "False" "38.536" "20" "7" "11" "4" "518" "55.2" "8.95" "49.04" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10239" "25940" "ENSG00000119812" "FAM98A" "B2RNA2; hsa:25940; Q8NCA5; Q9Y3Y6" "" "" "0" "0" "1.093" "1.129" "1.023" "1.131" "1.243" "1.121" "1.098" "1.094" "0.952" "331.0" "361.9" "373.6" "338.6" "374.3" "411.3" "371.1" "363.5" "362.2" "315.0" "" "" "" "" "" "" "" "" "" "" "297.6" "292.8" "338.0" "330.6" "308.9" "411.3" "277.9" "321.0" "324.1" "112.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1348020526010624498" "False" "High" "IsMasterProtein" "Q13469" "Nuclear factor of activated T-cells, cytoplasmic 2 OS=Homo sapiens OX=9606 GN=NFATC2 PE=1 SV=2" "0.000" "False" "38.514" "15" "11" "15" "11" "925" "100.1" "7.28" "47.92" "11" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4773" "ENSG00000101096" "NFATC2" "B5B2N8; B5B2N9; B5B2P0; B5B2P2; B5B2P3; hsa:4773; Q13468; Q13469; Q5TFW7; Q5TFW8; Q9NPX6; Q9NQH3; Q9UJR2" "Heart development; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; Cardiac hypertrophic response; Hematopoietic stem cell differentiation; Vitamin D receptor pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; Wnt signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; CAMKK2 pathway; 16p11.2 distal deletion syndrome; Calcium mediated T-cell apoptosis involved in inclusion body myositis; T-cell receptor signaling pathway" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)" "21" "0" "1.035" "1.037" "0.961" "0.989" "1.051" "1.024" "0.999" "1.044" "1.109" "734.5" "760.1" "761.6" "706.2" "726.4" "772.2" "752.4" "733.7" "766.7" "814.2" "" "" "" "" "" "" "" "" "" "" "660.4" "615.1" "688.9" "689.4" "599.5" "772.2" "563.4" "648.0" "686.1" "290.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-398928808883879512" "False" "High" "IsMasterProtein" "P07311" "Acylphosphatase-1 OS=Homo sapiens OX=9606 GN=ACYP1 PE=1 SV=2" "0.000" "False" "38.502" "67" "7" "14" "7" "99" "11.3" "9.31" "45.55" "7" "other metabolic processes" "" "other molecular function" "Pf00708" "97" "ENSG00000119640" "ACYP1" "A6NDV8; B2R590; hsa:97; P07311" "" "" "0" "0" "1.010" "1.107" "0.970" "1.004" "1.084" "1.018" "0.962" "1.053" "0.820" "1557.5" "1573.2" "1724.6" "1511.1" "1563.8" "1689.0" "1585.4" "1498.9" "1639.4" "1276.7" "" "" "" "" "" "" "" "" "" "" "1400.3" "1273.0" "1560.0" "1475.0" "1290.5" "1689.0" "1187.1" "1324.0" "1467.0" "455.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585340363182511889" "False" "High" "IsMasterProtein" "Q9HBU6" "Ethanolamine kinase 1 OS=Homo sapiens OX=9606 GN=ETNK1 PE=1 SV=1" "0.000" "False" "38.446" "25" "11" "13" "10" "452" "50.9" "6.54" "53.90" "11" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "55500" "ENSG00000139163" "ETNK1" "G5E969; hsa:55500; Q9HBU6" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PE" "5" "0" "1.018" "1.220" "0.897" "0.983" "1.115" "0.912" "1.015" "1.150" "0.875" "1336.0" "1359.9" "1630.6" "1198.4" "1313.3" "1489.7" "1218.7" "1355.7" "1536.0" "1168.6" "" "" "" "" "" "" "" "" "" "" "1201.2" "1100.4" "1474.9" "1169.8" "1083.8" "1489.7" "912.5" "1197.4" "1374.4" "417.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2243304084648640018" "False" "High" "IsMasterProtein" "P49585" "Choline-phosphate cytidylyltransferase A OS=Homo sapiens OX=9606 GN=PCYT1A PE=1 SV=2" "0.000" "False" "38.437" "31" "11" "14" "11" "367" "41.7" "7.25" "45.81" "11" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01467" "5130" "ENSG00000161217" "PCYT1A" "A9LYK9; D3DXB1; hsa:5130; P49585; Q86Y88" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids; 3q29 copy number variation syndrome; Acetylcholine synthesis" "Synthesis of PC" "7" "0" "0.994" "0.978" "1.073" "0.985" "0.994" "1.043" "1.043" "0.987" "1.139" "1004.6" "998.8" "982.2" "1077.9" "989.2" "998.3" "1048.1" "1047.4" "992.0" "1143.9" "" "" "" "" "" "" "" "" "" "" "903.2" "808.2" "888.4" "1052.2" "816.3" "998.3" "784.8" "925.2" "887.7" "408.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "499510966834701259" "False" "High" "IsMasterProtein" "Q96GS4" "BLOC-1-related complex subunit 6 OS=Homo sapiens OX=9606 GN=BORCS6 PE=1 SV=2" "0.000" "False" "38.390" "27" "7" "10" "7" "357" "37.2" "5.76" "43.32" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf10157" "54785" "ENSG00000196544" "BORCS6" "hsa:54785; Q53HS4; Q96GS4; Q9NXW8" "" "" "0" "0" "0.972" "1.075" "0.955" "1.143" "1.091" "1.147" "1.019" "1.005" "1.038" "624.5" "607.0" "671.2" "596.4" "714.1" "681.2" "716.2" "636.5" "627.6" "648.2" "" "" "" "" "" "" "" "" "" "" "561.5" "491.2" "607.1" "582.2" "589.3" "681.2" "536.3" "562.2" "561.6" "231.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003283534467846840" "False" "High" "IsMasterProtein" "P40937" "Replication factor C subunit 5 OS=Homo sapiens OX=9606 GN=RFC5 PE=1 SV=1" "0.000" "False" "38.376" "39" "13" "14" "13" "340" "38.5" "7.20" "47.52" "13" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5985" "ENSG00000111445" "RFC5" "A8MZ62; B3KSX8; hsa:5985; P40937" "Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "HDR through Homologous Recombination (HRR); Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "1.095" "1.184" "1.001" "1.055" "1.271" "1.070" "1.066" "1.332" "0.938" "1269.8" "1391.0" "1503.6" "1270.9" "1339.4" "1614.4" "1358.5" "1353.9" "1691.2" "1190.9" "" "" "" "" "" "" "" "" "" "" "1141.7" "1125.6" "1360.1" "1240.6" "1105.3" "1614.4" "1017.2" "1195.8" "1513.3" "425.1" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3114366665604462397" "False" "High" "IsMasterProtein" "Q9BZE2" "tRNA pseudouridine(38/39) synthase OS=Homo sapiens OX=9606 GN=PUS3 PE=1 SV=3" "0.000" "False" "38.373" "24" "10" "15" "10" "481" "55.6" "7.49" "56.17" "10" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "83480" "ENSG00000110060" "PUS3" "B2RAM0; hsa:83480; Q96D17; Q96J23; Q96NB4; Q9BZE2" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.010" "1.057" "0.958" "1.052" "1.042" "1.046" "1.035" "1.065" "0.892" "972.2" "981.6" "1027.2" "931.7" "1022.7" "1012.6" "1017.1" "1006.2" "1035.1" "867.3" "" "" "" "" "" "" "" "" "" "" "874.1" "794.3" "929.1" "909.5" "843.9" "1012.6" "761.5" "888.8" "926.2" "309.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6087199310060456450" "False" "High" "IsMasterProtein" "Q9UI30" "Multifunctional methyltransferase subunit TRM112-like protein OS=Homo sapiens OX=9606 GN=TRMT112 PE=1 SV=1" "0.000" "False" "38.354" "64" "7" "15" "7" "125" "14.2" "5.26" "56.00" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03966" "51504" "ENSG00000173113" "TRMT112" "B2R539; hsa:51504; J3KNG5; Q3MHC7; Q8N2Z4; Q9UI30" "" "tRNA modification in the nucleus and cytosol; rRNA modification in the nucleus and cytosol; Methylation; Eukaryotic Translation Termination" "4" "0" "1.011" "0.986" "0.995" "1.047" "1.082" "1.016" "1.033" "1.059" "1.026" "951.1" "961.6" "937.4" "946.6" "995.6" "1029.4" "966.1" "982.4" "1006.8" "975.7" "" "" "" "" "" "" "" "" "" "" "855.1" "778.1" "847.9" "924.0" "821.6" "1029.4" "723.4" "867.7" "900.9" "348.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1695167521897825927" "False" "High" "IsMasterProtein" "P53609" "Geranylgeranyl transferase type-1 subunit beta OS=Homo sapiens OX=9606 GN=PGGT1B PE=1 SV=2" "0.000" "False" "38.343" "27" "10" "18" "10" "377" "42.3" "6.83" "57.64" "10" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00432" "5229" "ENSG00000164219" "PGGT1B" "hsa:5229; P53609; Q5MJP9" "" "" "0" "0" "1.062" "1.021" "1.100" "1.030" "1.014" "1.029" "1.066" "1.091" "0.997" "1125.2" "1194.8" "1149.4" "1237.4" "1158.9" "1141.0" "1157.7" "1200.0" "1227.4" "1122.2" "" "" "" "" "" "" "" "" "" "" "1011.7" "966.8" "1039.7" "1207.8" "956.3" "1141.0" "866.8" "1059.9" "1098.2" "400.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910081975799465505" "False" "High" "IsMasterProtein" "O15042" "U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens OX=9606 GN=U2SURP PE=1 SV=2" "0.000" "False" "38.332" "13" "12" "14" "12" "1029" "118.2" "8.47" "48.46" "12" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076, Pf01805, Pf04818, Pf08312" "23350" "ENSG00000163714" "U2SURP" "A0PJ60; hsa:23350; O15042; Q0D2M1; Q2NKQ7; Q9BR70" "" "mRNA Splicing - Major Pathway" "1" "0" "0.947" "1.000" "0.879" "0.925" "1.082" "0.958" "0.906" "0.880" "1.320" "1458.2" "1381.5" "1457.8" "1281.7" "1349.1" "1577.7" "1396.3" "1320.8" "1283.8" "1925.2" "" "" "" "" "" "" "" "" "" "" "1311.1" "1117.9" "1318.6" "1251.1" "1113.3" "1577.7" "1045.5" "1166.7" "1148.7" "687.2" "11" "11" "11" "11" "11" "11" "11" "11" "11" "11" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "968979890096343817" "False" "High" "IsMasterProtein" "P53611" "Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens OX=9606 GN=RABGGTB PE=1 SV=2" "0.000" "False" "38.302" "25" "9" "18" "9" "331" "36.9" "5.03" "64.05" "9" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00432" "5876" "ENSG00000137955" "RABGGTB" "hsa:5876; P53611; Q92697" "" "RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "2" "0" "0.954" "1.020" "0.967" "1.015" "0.918" "1.018" "0.971" "1.000" "1.013" "1201.7" "1145.9" "1225.8" "1162.1" "1219.2" "1102.9" "1223.0" "1167.3" "1201.5" "1217.4" "" "" "" "" "" "" "" "" "" "" "1080.4" "927.2" "1108.8" "1134.4" "1006.1" "1102.9" "915.7" "1031.1" "1075.1" "434.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8342243932904844919" "False" "High" "IsMasterProtein" "Q13555" "Calcium/calmodulin-dependent protein kinase type II subunit gamma OS=Homo sapiens OX=9606 GN=CAMK2G PE=1 SV=4" "0.000" "False" "38.287" "17" "8" "13" "4" "558" "62.6" "7.83" "47.16" "8" "cell-cell signaling;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08332" "818" "ENSG00000148660" "CAMK2G" "A0A0A0MS52; A0A0A0MT11; hsa:818; O00561; O15378; Q13279; Q13282; Q13555; Q13556; Q5SQZ3; Q5SQZ4; Q5SWX4; Q7KYX5; Q8N4I3; Q8NIA4" "Energy metabolism; Myometrial relaxation and contraction pathways; NO/cGMP/PKG mediated neuroprotection; Splicing factor NOVA regulated synaptic proteins; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Disruption of postsynaptic signaling by CNV; Neuroinflammation and glutamatergic signaling; Calcium regulation in cardiac cells; ErbB signaling pathway" "RAF activation; Assembly and cell surface presentation of NMDA receptors; Ion homeostasis; Ion transport by P-type ATPases; Signaling by BRAF and RAF1 fusions; Interferon gamma signaling; Ras activation upon Ca2+ influx through NMDA receptor; Regulation of MECP2 expression and activity; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Phase 0 - rapid depolarisation; HSF1-dependent transactivation; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde" "31" "0" "0.994" "0.878" "0.940" "0.909" "0.880" "0.908" "0.979" "0.945" "0.803" "532.7" "529.7" "467.6" "501.0" "484.2" "468.8" "483.7" "521.4" "503.4" "427.8" "" "" "" "" "" "" "" "" "" "" "478.9" "428.6" "423.0" "489.0" "399.5" "468.8" "362.2" "460.6" "450.5" "152.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6073254106150692843" "False" "High" "IsMasterProtein" "Q99575" "Ribonucleases P/MRP protein subunit POP1 OS=Homo sapiens OX=9606 GN=POP1 PE=1 SV=2" "0.000" "False" "38.275" "15" "11" "14" "11" "1024" "114.6" "9.22" "55.00" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06978, Pf08170" "10940" "ENSG00000104356" "POP1" "A8K5W9; Q15037; Q99575" "" "tRNA processing in the nucleus" "1" "0" "1.012" "0.979" "0.968" "0.947" "0.878" "0.976" "0.966" "0.891" "0.902" "798.3" "807.7" "781.7" "772.5" "756.2" "701.0" "779.2" "771.4" "711.6" "719.7" "" "" "" "" "" "" "" "" "" "" "717.7" "653.6" "707.0" "754.1" "624.0" "701.0" "583.4" "681.4" "636.7" "256.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4492999109905159377" "False" "High" "IsMasterProtein" "Q15121" "Astrocytic phosphoprotein PEA-15 OS=Homo sapiens OX=9606 GN=PEA15 PE=1 SV=2" "0.000" "False" "38.264" "59" "7" "14" "7" "130" "15.0" "5.02" "54.00" "7" "transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01335" "8682" "ENSG00000162734" "PEA15" "B1AKZ3; hsa:8682; O00511; Q15121" "Apoptosis modulation and signaling" "RAF/MAP kinase cascade; RAF-independent MAPK1/3 activation" "3" "0" "0.986" "1.071" "0.964" "1.093" "1.044" "1.045" "1.006" "1.017" "0.978" "866.6" "854.8" "927.9" "835.8" "946.9" "904.9" "905.4" "871.5" "881.1" "847.8" "" "" "" "" "" "" "" "" "" "" "779.1" "691.7" "839.3" "815.8" "781.4" "904.9" "677.9" "769.8" "788.4" "302.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1007819713485126010" "False" "High" "IsMasterProtein" "P83916" "Chromobox protein homolog 1 OS=Homo sapiens OX=9606 GN=CBX1 PE=1 SV=1" "0.000" "False" "38.180" "24" "3" "18" "2" "185" "21.4" "4.93" "85.77" "3" "cell organization and biogenesis;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00385, Pf01393" "10951" "ENSG00000108468" "CBX1" "hsa:10951; P23197; P83916" "Effect of progerin on genes involved in progeria" "HCMV Early Events" "2" "0" "0.961" "0.902" "0.884" "1.037" "0.887" "0.927" "0.966" "0.860" "0.701" "412.7" "396.5" "372.1" "364.7" "427.9" "366.1" "382.5" "398.5" "355.1" "289.5" "" "" "" "" "" "" "" "" "" "" "371.1" "320.8" "336.6" "356.0" "353.1" "366.1" "286.4" "352.0" "317.8" "103.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3812741614734953835" "False" "High" "IsMasterProtein" "Q7L9L4" "MOB kinase activator 1B OS=Homo sapiens OX=9606 GN=MOB1B PE=1 SV=3" "0.000" "False" "38.175" "29" "6" "16" "6" "216" "25.1" "6.73" "48.41" "6" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "92597" "ENSG00000173542" "MOB1B" "B2R8U6; B4DRY3; hsa:92597; Q7L9L4; Q8IY23" "Pleural mesothelioma" "Signaling by Hippo" "2" "0" "0.990" "1.060" "1.014" "1.064" "0.960" "1.021" "1.089" "1.094" "0.831" "1860.2" "1842.1" "1972.5" "1885.4" "1979.5" "1785.6" "1899.5" "2026.0" "2035.5" "1544.9" "" "" "" "" "" "" "" "" "" "" "1672.5" "1490.6" "1784.2" "1840.4" "1633.5" "1785.6" "1422.3" "1789.5" "1821.4" "551.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1732426368668540463" "False" "High" "IsMasterProtein" "Q8N9N8" "Probable RNA-binding protein EIF1AD OS=Homo sapiens OX=9606 GN=EIF1AD PE=1 SV=1" "0.000" "False" "38.147" "57" "8" "12" "8" "165" "19.0" "5.21" "46.46" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01176" "84285" "ENSG00000175376" "EIF1AD" "B2R4N5; hsa:84285; Q8N9N8; Q9BSC1" "" "" "0" "0" "1.020" "1.062" "0.868" "1.080" "1.101" "1.064" "0.979" "0.977" "0.834" "1006.7" "1027.3" "1069.1" "873.5" "1087.2" "1108.1" "1070.8" "985.4" "984.0" "840.0" "" "" "" "" "" "" "" "" "" "" "905.1" "831.2" "967.1" "852.6" "897.2" "1108.1" "801.8" "870.4" "880.4" "299.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6115802108714275107" "False" "High" "IsMasterProtein" "P78330" "Phosphoserine phosphatase OS=Homo sapiens OX=9606 GN=PSPH PE=1 SV=2" "0.000" "False" "38.146" "40" "8" "14" "8" "225" "25.0" "5.69" "50.10" "8" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00702" "5723" "ENSG00000146733" "PSPH" "B2RCR5; hsa:5723; P78330; Q7Z3S5" "Trans-sulfuration, one-carbon metabolism and related pathways; Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Neuroinflammation and glutamatergic signaling; Amino acid metabolism in triple-negative breast cancer cells" "Serine biosynthesis" "6" "0" "1.015" "0.933" "0.947" "1.023" "0.889" "0.991" "0.966" "0.928" "0.732" "1335.1" "1355.6" "1246.2" "1263.7" "1365.8" "1186.9" "1322.6" "1290.2" "1239.2" "977.0" "" "" "" "" "" "" "" "" "" "" "1200.4" "1096.9" "1127.2" "1233.6" "1127.1" "1186.9" "990.3" "1139.6" "1108.9" "348.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8026992804565503724" "False" "High" "IsMasterProtein" "Q13257" "Mitotic spindle assembly checkpoint protein MAD2A OS=Homo sapiens OX=9606 GN=MAD2L1 PE=1 SV=1" "0.000" "False" "38.122" "36" "7" "17" "7" "205" "23.5" "5.08" "64.72" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf02301" "4085" "ENSG00000164109" "MAD2L1" "hsa:4085; Q13257; Q53F56; Q548X9; Q6IRW7; Q8IZX3" "Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of mitotic proteins; APC-Cdc20 mediated degradation of Nek2A" "13" "0" "0.993" "0.967" "0.923" "1.020" "0.854" "0.929" "0.897" "0.946" "1.061" "1430.2" "1420.0" "1382.9" "1320.1" "1458.1" "1220.8" "1328.8" "1282.3" "1353.0" "1517.8" "" "" "" "" "" "" "" "" "" "" "1285.9" "1149.0" "1250.9" "1288.6" "1203.2" "1220.8" "995.0" "1132.6" "1210.7" "541.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6640745081908687038" "False" "High" "IsMasterProtein" "O75521" "Enoyl-CoA delta isomerase 2 OS=Homo sapiens OX=9606 GN=ECI2 PE=1 SV=4" "0.000" "False" "38.093" "24" "6" "12" "6" "394" "43.6" "9.00" "59.00" "6" "other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00378, Pf00887" "10455" "ENSG00000198721" "ECI2" "hsa:10455; O75521; Q5JYK5; Q5JYK7; Q7L124; Q8N0X0; Q9BUE9; Q9H0T9; Q9NQH1; Q9NYH7; Q9UN55" "" "" "0" "0" "0.958" "0.976" "0.890" "0.999" "0.982" "1.005" "0.977" "0.954" "0.828" "712.7" "682.6" "695.3" "634.2" "711.7" "699.8" "716.0" "696.4" "680.1" "589.9" "" "" "" "" "" "" "" "" "" "" "640.8" "552.3" "628.9" "619.0" "587.3" "699.8" "536.2" "615.1" "608.5" "210.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "456544607600152383" "False" "High" "IsMasterProtein" "Q9UJY5" "ADP-ribosylation factor-binding protein GGA1 OS=Homo sapiens OX=9606 GN=GGA1 PE=1 SV=1" "0.000" "False" "38.086" "13" "10" "14" "10" "639" "70.3" "5.29" "46.29" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "26088" "ENSG00000100083" "GGA1" "A8K3D3; B0QYR7; hsa:26088; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; Q9UJY5" "" "TBC/RABGAPs; Amyloid fiber formation" "2" "0" "1.038" "1.025" "1.017" "1.063" "0.980" "1.086" "1.056" "1.025" "1.051" "1768.0" "1835.1" "1812.8" "1797.5" "1878.6" "1732.1" "1920.4" "1867.4" "1811.5" "1857.8" "" "" "" "" "" "" "" "" "" "" "1589.6" "1484.9" "1639.7" "1754.6" "1550.3" "1732.1" "1438.0" "1649.4" "1621.0" "663.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "59184659773015562" "False" "High" "IsMasterProtein" "Q969H8" "Myeloid-derived growth factor OS=Homo sapiens OX=9606 GN=MYDGF PE=1 SV=1" "0.000" "False" "37.989" "31" "7" "14" "7" "173" "18.8" "6.68" "48.66" "7" "developmental processes;other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf10572" "56005" "ENSG00000074842" "MYDGF" "D6W628; hsa:56005; O75256; O75272; Q969H8; Q9BTK7; Q9NP69" "" "XBP1(S) activates chaperone genes" "1" "0" "0.986" "1.009" "1.089" "0.983" "0.991" "1.024" "1.024" "1.015" "0.840" "1973.5" "1945.4" "1991.9" "2148.8" "1940.8" "1955.5" "2021.3" "2021.0" "2002.4" "1657.4" "" "" "" "" "" "" "" "" "" "" "1774.4" "1574.2" "1801.8" "2097.5" "1601.6" "1955.5" "1513.5" "1785.0" "1791.7" "591.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811509789942253503" "False" "High" "IsMasterProtein" "Q7Z6M1" "Rab9 effector protein with kelch motifs OS=Homo sapiens OX=9606 GN=RABEPK PE=1 SV=1" "0.000" "False" "37.980" "28" "9" "12" "9" "372" "40.5" "6.25" "41.58" "9" "transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01344, Pf07646, Pf13415" "10244" "ENSG00000136933" "RABEPK" "A8K403; hsa:10244; O00568; Q69YR2; Q6FHA4; Q6IBG7; Q6P092; Q7Z6M1; Q86Y76; Q9BWB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.033" "1.059" "1.005" "1.052" "0.988" "0.983" "1.051" "0.955" "0.877" "551.8" "569.9" "584.6" "554.3" "580.7" "545.2" "542.6" "580.2" "527.2" "483.9" "" "" "" "" "" "" "" "" "" "" "496.1" "461.1" "528.7" "541.1" "479.2" "545.2" "406.3" "512.5" "471.8" "172.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7795104145569461525" "False" "High" "IsMasterProtein" "Q2M389" "WASH complex subunit 4 OS=Homo sapiens OX=9606 GN=WASHC4 PE=1 SV=2" "0.000" "False" "37.930" "11" "13" "14" "13" "1173" "136.3" "7.44" "48.44" "13" "cell organization and biogenesis;transport;other biological processes" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14744, Pf14745, Pf14746" "23325" "ENSG00000136051" "WASHC4" "hsa:23325; Q2M389; Q2NL83; Q8IW61; Q8N5W7; Q9NVD6; Q9UPW7" "" "" "0" "0" "0.933" "0.926" "0.937" "0.919" "0.891" "0.987" "0.918" "0.945" "1.261" "1078.3" "1006.3" "998.6" "1010.9" "991.2" "960.5" "1064.6" "990.4" "1018.5" "1360.2" "" "" "" "" "" "" "" "" "" "" "969.5" "814.2" "903.3" "986.8" "818.0" "960.5" "797.2" "874.8" "911.4" "485.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1388353290409054284" "False" "High" "IsMasterProtein" "Q9NNW7" "Thioredoxin reductase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TXNRD2 PE=1 SV=3" "0.000" "False" "37.892" "20" "8" "10" "7" "524" "56.5" "7.50" "46.01" "8" "stress response;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf02852, Pf07992" "10587" "ENSG00000184470" "TXNRD2" "hsa:10587; O95840; Q96IJ2; Q9H2Z5; Q9NNW7; Q9NZV3; Q9NZV4; Q9P2Y0; Q9P2Y1; Q9UQU8" "Selenium micronutrient network; Selenium micronutrient network ; Selenium micronutrient network; Selenium metabolism and selenoproteins; Oxidative stress response; 22q11.2 copy number variation syndrome" "Detoxification of Reactive Oxygen Species" "7" "0" "1.023" "1.091" "0.960" "1.236" "1.127" "1.019" "1.136" "1.167" "1.055" "750.3" "767.6" "818.4" "720.3" "927.3" "845.9" "764.3" "852.6" "875.7" "791.3" "" "" "" "" "" "" "" "" "" "" "674.6" "621.1" "740.3" "703.1" "765.2" "845.9" "572.3" "753.1" "783.6" "282.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1240749293216846131" "False" "High" "IsMasterProtein" "Q13526" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 OS=Homo sapiens OX=9606 GN=PIN1 PE=1 SV=1" "0.000" "False" "37.842" "42" "5" "16" "5" "163" "18.2" "8.82" "69.61" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00397, Pf00639" "5300" "ENSG00000127445" "PIN1" "A8K4V9; hsa:5300; Q13526; Q53X75" "Novel intracellular components of RIG-I-like receptor pathway" "Regulation of TP53 Activity through Phosphorylation; ISG15 antiviral mechanism; Negative regulators of DDX58/IFIH1 signaling; PI5P Regulates TP53 Acetylation; RHO GTPases Activate NADPH Oxidases" "6" "0" "1.046" "0.994" "0.992" "1.045" "1.220" "1.068" "1.116" "1.048" "0.870" "1147.5" "1200.8" "1140.1" "1138.3" "1199.7" "1400.0" "1225.6" "1280.7" "1202.8" "998.6" "" "" "" "" "" "" "" "" "" "" "1031.7" "971.7" "1031.3" "1111.2" "990.0" "1400.0" "917.7" "1131.2" "1076.2" "356.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6212598245542673461" "False" "High" "IsMasterProtein" "Q92879" "CUGBP Elav-like family member 1 OS=Homo sapiens OX=9606 GN=CELF1 PE=1 SV=2" "0.000" "False" "37.814" "19" "9" "15" "7" "486" "52.0" "8.46" "52.21" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10658" "ENSG00000149187" "CELF1" "B4E2U5; D3DQS0; F8W940; Q4LE52; Q92879; Q9NP83; Q9NR06" "Adipogenesis; mRNA processing" "" "2" "0" "1.078" "1.051" "1.093" "1.003" "1.048" "1.097" "0.969" "1.034" "2.511" "687.1" "740.8" "721.9" "751.4" "688.9" "720.3" "753.6" "665.7" "710.3" "1725.4" "" "" "" "" "" "" "" "" "" "" "617.8" "599.4" "653.0" "733.4" "568.5" "720.3" "564.2" "588.0" "635.6" "615.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230612763215460817" "False" "High" "IsMasterProtein" "Q99829" "Copine-1 OS=Homo sapiens OX=9606 GN=CPNE1 PE=1 SV=1" "0.000" "False" "37.810" "18" "10" "17" "10" "537" "59.0" "5.83" "59.92" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf07002" "8904" "ENSG00000214078" "CPNE1" "E1P5Q4; hsa:8904; Q6IBL3; Q99829; Q9H243; Q9NTZ7" "" "Neutrophil degranulation; Glycerophospholipid biosynthesis" "2" "0" "1.006" "0.956" "0.946" "0.967" "0.912" "0.921" "0.947" "0.935" "0.776" "3066.5" "3085.2" "2931.9" "2900.0" "2964.9" "2798.1" "2824.6" "2904.4" "2868.7" "2379.5" "" "" "" "" "" "" "" "" "" "" "2757.1" "2496.4" "2652.0" "2830.8" "2446.7" "2798.1" "2115.0" "2565.4" "2566.9" "849.4" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1699375806796057255" "False" "High" "IsMasterProtein" "Q6IA69" "Glutamine-dependent NAD(+) synthetase OS=Homo sapiens OX=9606 GN=NADSYN1 PE=1 SV=3" "0.000" "False" "37.802" "14" "8" "12" "8" "706" "79.2" "6.44" "46.28" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00795, Pf02540" "55191" "ENSG00000172890" "NADSYN1" "B3KUU4; hsa:55191; Q6IA69; Q86SN2; Q9HA25; Q9NVM8" "NAD biosynthesis II (from tryptophan); NAD+ biosynthetic pathways" "Nicotinate metabolism" "3" "0" "1.095" "1.048" "0.927" "1.118" "1.035" "1.061" "0.988" "1.033" "0.896" "1154.1" "1263.5" "1209.8" "1070.1" "1290.7" "1194.6" "1224.5" "1140.8" "1191.9" "1033.6" "" "" "" "" "" "" "" "" "" "" "1037.6" "1022.4" "1094.3" "1044.6" "1065.1" "1194.6" "916.9" "1007.6" "1066.5" "369.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1270194887050037302" "False" "High" "IsMasterProtein" "Q9UBW8" "COP9 signalosome complex subunit 7a OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1" "0.000" "False" "37.790" "27" "7" "14" "7" "275" "30.3" "8.22" "56.32" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf01399, Pf18392" "50813" "ENSG00000111652" "COPS7A" "A8K9A6; hsa:50813; Q9NVX3; Q9UBW8; Q9UJW4" "Ciliary landscape" "Cargo recognition for clathrin-mediated endocytosis; Formation of TC-NER Pre-Incision Complex; Neddylation; DNA Damage Recognition in GG-NER" "5" "0" "1.026" "1.027" "1.032" "1.109" "1.039" "1.074" "1.036" "1.106" "0.827" "1307.4" "1341.3" "1342.6" "1348.7" "1449.7" "1359.0" "1404.7" "1354.6" "1446.3" "1081.5" "" "" "" "" "" "" "" "" "" "" "1175.5" "1085.4" "1214.5" "1316.5" "1196.3" "1359.0" "1051.8" "1196.5" "1294.1" "386.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6980726595472841033" "False" "High" "IsMasterProtein" "P24941" "Cyclin-dependent kinase 2 OS=Homo sapiens OX=9606 GN=CDK2 PE=1 SV=2" "0.000" "False" "37.492" "33" "9" "16" "7" "298" "33.9" "8.68" "56.45" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00069" "1017" "ENSG00000123374" "CDK2" "A8K7C6; hsa:1017; O75100; P24941" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; DNA replication; p53 transcriptional gene network; Pleural mesothelioma; Sphingolipid metabolism in senescence; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; DNA damage response" "CDK-mediated phosphorylation and removal of Cdc6; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Orc1 removal from chromatin; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; G2 Phase; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Telomere Extension By Telomerase; Factors involved in megakaryocyte development and platelet production; Processing of DNA double-strand break ends; Cyclin A/B1/B2 associated events during G2/M transition; Meiotic recombination; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "47" "0" "1.034" "1.395" "0.902" "0.989" "1.261" "1.038" "0.966" "1.264" "1.011" "481.8" "498.0" "672.0" "434.7" "476.4" "607.4" "500.2" "465.4" "609.1" "487.1" "" "" "" "" "" "" "" "" "" "" "433.2" "403.0" "607.8" "424.3" "393.1" "607.4" "374.5" "411.1" "545.0" "173.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7065461624018501642" "False" "High" "IsMasterProtein" "Q96JB5" "CDK5 regulatory subunit-associated protein 3 OS=Homo sapiens OX=9606 GN=CDK5RAP3 PE=1 SV=2" "0.000" "False" "37.467" "18" "10" "15" "10" "506" "56.9" "4.75" "41.88" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05600" "80279" "ENSG00000108465" "CDK5RAP3" "B7Z6N4; D3DTU1; D3DTU2; F5H3I5; hsa:80279; Q53FA2; Q96JB5; Q9H3F8; Q9H8G0; Q9HBR9" "" "" "0" "0" "0.953" "1.085" "1.077" "1.050" "1.122" "1.046" "1.141" "1.149" "1.165" "498.1" "474.6" "540.3" "536.4" "523.2" "558.8" "521.1" "568.2" "572.4" "580.2" "" "" "" "" "" "" "" "" "" "" "447.9" "384.1" "488.7" "523.6" "431.8" "558.8" "390.2" "501.9" "512.2" "207.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3778187452605941811" "False" "High" "IsMasterProtein" "Q9NZ52" "ADP-ribosylation factor-binding protein GGA3 OS=Homo sapiens OX=9606 GN=GGA3 PE=1 SV=1" "0.000" "False" "37.423" "13" "8" "11" "8" "723" "78.3" "5.58" "44.39" "8" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23163" "ENSG00000125447" "GGA3" "B7Z7E2; B7Z7M9; hsa:23163; J3KRN0; Q15017; Q6IS16; Q9NZ52; Q9UJY3" "" "Amyloid fiber formation; TBC/RABGAPs; MET receptor recycling" "3" "0" "1.008" "1.002" "0.979" "1.044" "0.949" "1.054" "0.974" "0.971" "1.131" "1084.0" "1092.7" "1086.2" "1061.3" "1131.4" "1028.2" "1142.1" "1055.5" "1052.7" "1225.6" "" "" "" "" "" "" "" "" "" "" "974.6" "884.2" "982.5" "1036.0" "933.6" "1028.2" "855.2" "932.3" "942.0" "437.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5585916410181359903" "False" "High" "IsMasterProtein" "Q6IQ49" "Splicing regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1" "0.000" "False" "37.364" "24" "9" "16" "9" "451" "49.7" "6.05" "59.41" "9" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf13019, Pf13297" "163859" "ENSG00000143751" "SDE2" "A8K4P3; hsa:163859; Q5TD36; Q6IQ49; Q6ZS26; Q8NAG7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.917" "0.991" "0.963" "1.027" "1.034" "1.023" "1.007" "1.052" "0.937" "1355.9" "1242.9" "1344.2" "1305.0" "1392.4" "1401.9" "1386.9" "1364.9" "1426.6" "1270.9" "" "" "" "" "" "" "" "" "" "" "1219.1" "1005.7" "1215.9" "1273.9" "1149.1" "1401.9" "1038.5" "1205.5" "1276.5" "453.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3306595998206250770" "False" "High" "IsMasterProtein" "P62753" "Small ribosomal subunit protein eS6 OS=Homo sapiens OX=9606 GN=RPS6 PE=1 SV=1" "0.000" "False" "37.334" "22" "6" "12" "6" "249" "28.7" "10.84" "48.75" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01092" "6194" "ENSG00000137154" "RPS6" "hsa:6194; P08227; P10660; P62753; Q4VBY7; Q8N6Z7" "IL-5 signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; MECP2 and associated Rett syndrome; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; IL-2 signaling pathway; Pleural mesothelioma; 2q37 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways" "SARS-CoV-2 modulates host translation machinery; Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; mTORC1-mediated signalling; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Nuclear events stimulated by ALK signaling in cancer; SARS-CoV-1 modulates host translation machinery" "49" "0" "0.967" "1.003" "0.876" "0.939" "0.976" "0.932" "0.854" "0.999" "1.116" "1440.0" "1392.9" "1444.7" "1261.2" "1352.7" "1406.1" "1341.9" "1229.8" "1439.2" "1606.7" "" "" "" "" "" "" "" "" "" "" "1294.7" "1127.1" "1306.8" "1231.1" "1116.3" "1406.1" "1004.8" "1086.2" "1287.8" "573.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5765890645847651977" "False" "High" "IsMasterProtein" "Q14790" "Caspase-8 OS=Homo sapiens OX=9606 GN=CASP8 PE=1 SV=1" "0.000" "False" "37.284" "21" "8" "11" "8" "479" "55.4" "5.10" "49.08" "8" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00656, Pf01335" "841" "ENSG00000064012" "CASP8" "hsa:841; O14676; Q14790; Q14791; Q14792; Q14793; Q14794; Q14795; Q14796; Q15780; Q15806; Q53TT5; Q8TDI1; Q8TDI2; Q8TDI3; Q8TDI4; Q8TDI5; Q96T22; Q9C0K4; Q9UQ81" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Parkin-ubiquitin proteasomal system pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; miRNA regulation of p53 pathway in prostate cancer; Non-small cell lung cancer; Acute viral myocarditis; Nonalcoholic fatty liver disease; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; 16p11.2 proximal deletion syndrome; Complement system in neuronal development and plasticity; CCL18 signaling pathway; Alzheimer's disease; DNA damage response; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NOD1/2 Signaling Pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Regulation of NF-kappa B signaling; TLR3-mediated TICAM1-dependent programmed cell death; Caspase-mediated cleavage of cytoskeletal proteins; TNFR1-induced proapoptotic signaling; CLEC7A/inflammasome pathway; Microbial modulation of RIPK1-mediated regulated necrosis; Activation, myristolyation of BID and translocation to mitochondria; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "54" "0" "1.051" "1.069" "0.995" "1.047" "1.036" "1.026" "1.054" "1.114" "1.759" "1122.3" "1179.0" "1200.0" "1116.2" "1175.2" "1162.3" "1151.3" "1183.2" "1250.0" "1974.1" "" "" "" "" "" "" "" "" "" "" "1009.0" "954.0" "1085.4" "1089.5" "969.8" "1162.3" "862.1" "1045.1" "1118.5" "704.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6036677964263745223" "False" "High" "IsMasterProtein" "Q8NFH4" "Nucleoporin Nup37 OS=Homo sapiens OX=9606 GN=NUP37 PE=1 SV=1" "0.000" "False" "37.251" "27" "8" "18" "8" "326" "36.7" "5.92" "62.88" "8" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "79023" "ENSG00000075188" "NUP37" "hsa:79023; Q8NFH4; Q9H644" "" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; ISG15 antiviral mechanism; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Vpr-mediated nuclear import of PICs; Transport of Mature mRNA derived from an Intron-Containing Transcript; tRNA processing in the nucleus; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; HCMV Late Events; HCMV Early Events; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.018" "1.008" "0.992" "1.060" "0.999" "0.992" "1.015" "1.078" "0.911" "1513.7" "1540.3" "1526.4" "1501.5" "1605.0" "1512.1" "1502.2" "1536.5" "1631.9" "1379.4" "" "" "" "" "" "" "" "" "" "" "1361.0" "1246.4" "1380.7" "1465.7" "1324.5" "1512.1" "1124.8" "1357.1" "1460.2" "492.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "173468840260374204" "False" "High" "IsMasterProtein" "Q86WB0" "Zinc finger C3HC-type protein 1 OS=Homo sapiens OX=9606 GN=ZC3HC1 PE=1 SV=1" "0.000" "False" "37.235" "25" "9" "13" "9" "502" "55.2" "5.62" "50.29" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf07967, Pf08600" "51530" "ENSG00000091732" "ZC3HC1" "A6NH66; hsa:51530; Q75MF3; Q75MF4; Q86WB0; Q8N330; Q96F75; Q9HA34; Q9NVX4; Q9P0R0" "" "Nuclear events stimulated by ALK signaling in cancer" "1" "0" "1.027" "1.005" "1.010" "1.033" "1.094" "1.113" "1.033" "1.075" "1.710" "747.9" "768.4" "751.3" "755.2" "772.5" "817.8" "832.7" "772.4" "804.2" "1278.7" "" "" "" "" "" "" "" "" "" "" "672.4" "621.8" "679.6" "737.2" "637.5" "817.8" "623.5" "682.2" "719.6" "456.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246140782840633700" "False" "High" "IsMasterProtein" "Q96B01" "RAD51-associated protein 1 OS=Homo sapiens OX=9606 GN=RAD51AP1 PE=1 SV=1" "0.000" "False" "37.233" "22" "7" "10" "7" "352" "38.4" "9.11" "41.34" "7" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf15696" "10635" "ENSG00000111247" "RAD51AP1" "A8K7D3; hsa:10635; O43403; Q7Z779; Q96B01" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange; Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "8" "0" "0.918" "1.075" "1.044" "0.969" "1.168" "1.068" "1.074" "1.170" "0.842" "1012.0" "929.1" "1088.4" "1056.2" "981.0" "1181.7" "1080.9" "1087.3" "1183.6" "852.3" "" "" "" "" "" "" "" "" "" "" "909.9" "751.8" "984.5" "1031.0" "809.5" "1181.7" "809.4" "960.4" "1059.1" "304.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4023730213020721894" "False" "High" "IsMasterProtein" "Q9NVX2" "Notchless protein homolog 1 OS=Homo sapiens OX=9606 GN=NLE1 PE=1 SV=4" "0.000" "False" "37.221" "25" "8" "10" "8" "485" "53.3" "7.34" "46.66" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "nucleus" "" "Pf00400, Pf08154" "54475" "ENSG00000073536" "NLE1" "hsa:54475; O60868; Q59GJ8; Q9BU54; Q9NVX2" "17q12 copy number variation syndrome" "" "1" "0" "1.015" "1.010" "1.067" "1.118" "1.019" "1.024" "1.055" "1.155" "0.847" "773.8" "785.5" "781.8" "825.3" "865.2" "788.4" "792.6" "816.3" "894.0" "655.2" "" "" "" "" "" "" "" "" "" "" "695.7" "635.6" "707.2" "805.6" "714.0" "788.4" "593.5" "721.0" "800.0" "233.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9164959202025983104" "False" "High" "IsMasterProtein" "Q9BSJ2" "Gamma-tubulin complex component 2 OS=Homo sapiens OX=9606 GN=TUBGCP2 PE=1 SV=2" "0.000" "False" "37.197" "13" "12" "14" "12" "902" "102.5" "6.84" "46.44" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf04130, Pf17681" "10844" "ENSG00000130640" "TUBGCP2" "B4DM18; B7ZKL8; F5H4E0; F5H4L0; hsa:10844; O43632; Q5VWX7; Q9BSJ2" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.002" "0.965" "0.976" "0.963" "1.036" "1.012" "0.965" "0.975" "1.141" "634.9" "636.3" "612.6" "619.9" "611.1" "657.8" "642.7" "612.5" "619.1" "724.4" "" "" "" "" "" "" "" "" "" "" "570.9" "514.9" "554.1" "605.1" "504.3" "657.8" "481.3" "541.0" "553.9" "258.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6887775823956767803" "False" "High" "IsMasterProtein" "P25440" "Bromodomain-containing protein 2 OS=Homo sapiens OX=9606 GN=BRD2 PE=1 SV=2" "0.000" "False" "37.192" "17" "14" "15" "12" "801" "88.0" "9.09" "49.02" "14" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00439, Pf17035" "6046" "ENSG00000204256; ENSG00000215077; ENSG00000234507; ENSG00000234704; ENSG00000235307" "BRD2" "A2AAU0; B0S7P0; B1AZT1; O00699; O00700; P25440; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4" "" "RUNX3 regulates p14-ARF" "1" "0" "1.050" "0.976" "1.011" "1.029" "1.018" "1.015" "0.968" "0.975" "1.873" "916.8" "963.1" "894.5" "927.1" "943.1" "932.9" "930.8" "887.3" "894.3" "1717.5" "" "" "" "" "" "" "" "" "" "" "824.3" "779.3" "809.1" "905.0" "778.3" "932.9" "697.0" "783.7" "800.2" "613.1" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3075207303668690710" "False" "High" "IsMasterProtein" "P37198" "Nuclear pore glycoprotein p62 OS=Homo sapiens OX=9606 GN=NUP62 PE=1 SV=3" "0.000" "False" "37.192" "17" "7" "10" "7" "522" "53.2" "5.31" "44.93" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05064" "23636" "ENSG00000213024" "NUP62" "B3KWU5; hsa:23636; P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1" "7q11.23 copy number variation syndrome" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; HCMV Early Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; Postmitotic nuclear pore complex (NPC) reformation" "30" "0" "0.927" "1.092" "0.971" "0.965" "0.921" "0.969" "0.921" "1.019" "1.277" "837.9" "776.5" "914.6" "813.3" "808.5" "771.8" "811.5" "771.7" "854.2" "1069.6" "" "" "" "" "" "" "" "" "" "" "753.3" "628.3" "827.3" "793.9" "667.2" "771.8" "607.7" "681.7" "764.3" "381.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5573566891233996467" "False" "High" "IsMasterProtein" "Q96FV2" "Secernin-2 OS=Homo sapiens OX=9606 GN=SCRN2 PE=1 SV=3" "0.000" "False" "37.183" "17" "6" "14" "6" "425" "46.6" "5.67" "44.62" "6" "protein metabolism" "" "other molecular function" "Pf03577" "90507" "ENSG00000141295" "SCRN2" "A8K3N1; B7Z8S7; E9PBV5; hsa:90507; Q96AC3; Q96FV2; Q9BU04" "" "" "0" "0" "1.100" "1.028" "0.982" "1.044" "1.031" "0.932" "1.015" "0.986" "0.984" "841.1" "925.4" "864.9" "826.0" "877.9" "867.6" "783.7" "853.9" "829.3" "828.0" "" "" "" "" "" "" "" "" "" "" "756.2" "748.8" "782.4" "806.3" "724.5" "867.6" "586.8" "754.2" "742.1" "295.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-597243898993742241" "False" "High" "IsMasterProtein" "P17096" "High mobility group protein HMG-I/HMG-Y OS=Homo sapiens OX=9606 GN=HMGA1 PE=1 SV=3" "0.000" "False" "37.180" "51" "7" "18" "7" "107" "11.7" "10.32" "69.81" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "" "3159" "ENSG00000137309" "HMGA1" "hsa:3159; P10910; P17096; Q5T6U9; Q9UKB0" "Adipogenesis; Pre-implantation embryo; Male infertility; 7q11.23 copy number variation syndrome; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Orexin receptor pathway" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "13" "0" "0.972" "0.977" "1.115" "0.879" "1.286" "1.143" "1.015" "0.976" "0.747" "1967.6" "1911.8" "1921.9" "2192.9" "1729.0" "2530.7" "2249.5" "1998.0" "1919.7" "1469.2" "" "" "" "" "" "" "" "" "" "" "1769.1" "1547.0" "1738.4" "2140.6" "1426.8" "2530.7" "1684.4" "1764.8" "1717.7" "524.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785444937320200778" "False" "High" "IsMasterProtein" "P17544" "Cyclic AMP-dependent transcription factor ATF-7 OS=Homo sapiens OX=9606 GN=ATF7 PE=1 SV=3" "0.000" "False" "37.165" "23" "11" "11" "8" "483" "51.7" "8.00" "43.49" "11" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "11016" "ENSG00000170653" "ATF7" "A5D6Y4; B2RMP1; B4DQL4; hsa:11016; P17544; Q13814; Q8IVR8; Q9UD83" "" "" "0" "2" "0.991" "1.000" "1.086" "1.037" "0.952" "1.050" "1.109" "0.976" "1.069" "1076.2" "1066.9" "1075.8" "1168.9" "1116.3" "1024.3" "1130.0" "1193.3" "1050.8" "1150.1" "" "" "" "" "" "" "" "" "" "" "967.6" "863.3" "973.1" "1141.0" "921.2" "1024.3" "846.1" "1054.0" "940.2" "410.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1787588940823929001" "False" "High" "IsMasterProtein" "P61224" "Ras-related protein Rap-1b OS=Homo sapiens OX=9606 GN=RAP1B PE=1 SV=1" "0.000" "False" "37.163" "38" "6" "15" "2" "184" "20.8" "5.78" "49.81" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5908" "ENSG00000127314" "RAP1B" "B2R5Z2; B4DQI8; B4DW74; B4DW94; hsa:5908; P09526; P61224; Q502X3; Q5TZR4; Q6DCA1; Q6LES0" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling" "Neutrophil degranulation; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "26" "4" "0.950" "0.990" "1.019" "0.978" "0.946" "0.971" "0.992" "1.108" "0.766" "2194.4" "2084.7" "2171.9" "2235.3" "2145.0" "2076.9" "2131.6" "2176.6" "2430.3" "1680.6" "" "" "" "" "" "" "" "" "" "" "1973.0" "1686.9" "1964.5" "2182.0" "1770.1" "2076.9" "1596.1" "1922.5" "2174.6" "599.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1415915778275113183" "False" "High" "IsMasterProtein" "Q7L273" "BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens OX=9606 GN=KCTD9 PE=1 SV=1" "0.000" "False" "37.034" "31" "9" "10" "9" "389" "42.5" "6.37" "42.05" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction" "" "other molecular function" "Pf00805, Pf02214, Pf11834" "54793" "ENSG00000104756" "KCTD9" "hsa:54793; Q6NUM8; Q7L273; Q9NXV4" "" "" "0" "0" "1.039" "1.069" "0.981" "1.097" "1.158" "1.050" "1.069" "1.111" "1.092" "362.2" "376.4" "387.3" "355.4" "397.2" "419.3" "380.2" "387.1" "402.4" "395.5" "" "" "" "" "" "" "" "" "" "" "325.7" "304.6" "350.4" "346.9" "327.8" "419.3" "284.7" "342.0" "360.1" "141.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6546315403352841289" "False" "High" "IsMasterProtein" "Q9Y2B0" "Protein canopy homolog 2 OS=Homo sapiens OX=9606 GN=CNPY2 PE=1 SV=1" "0.000" "False" "37.034" "51" "7" "15" "7" "182" "20.6" "4.92" "60.16" "7" "other biological processes" "ER/Golgi" "" "Pf11938" "10330" "ENSG00000257727" "CNPY2" "B2R7B9; Q9UHE9; Q9Y2B0" "" "" "0" "0" "0.927" "0.960" "0.916" "0.984" "0.984" "0.985" "1.009" "1.003" "0.767" "1638.5" "1518.8" "1573.2" "1501.7" "1612.5" "1612.2" "1613.3" "1653.6" "1642.7" "1256.7" "" "" "" "" "" "" "" "" "" "" "1473.2" "1229.0" "1423.0" "1465.9" "1330.7" "1612.2" "1208.0" "1460.6" "1469.8" "448.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6132827760965537069" "False" "High" "IsMasterProtein" "Q7Z3D6" "D-glutamate cyclase, mitochondrial OS=Homo sapiens OX=9606 GN=DGLUCY PE=1 SV=2" "0.000" "False" "36.981" "19" "9" "13" "9" "616" "66.4" "6.79" "46.72" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf07286, Pf14336" "80017" "ENSG00000133943" "DGLUCY" "B3KUI7; hsa:80017; Q7Z3D6; Q86SW3; Q86SX8; Q86SX9; Q86T08; Q86TV5; Q96GW5; Q9H7G0; Q9H8Y9; Q9H9W6" "" "" "0" "0" "1.030" "1.012" "1.150" "1.137" "0.987" "1.156" "1.028" "1.118" "0.737" "631.3" "650.4" "639.0" "725.8" "717.9" "623.0" "730.0" "648.9" "705.7" "465.3" "" "" "" "" "" "" "" "" "" "" "567.6" "526.3" "578.0" "708.5" "592.4" "623.0" "546.6" "573.2" "631.4" "166.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858307060055438950" "False" "High" "IsMasterProtein" "Q9HAB8" "Phosphopantothenate--cysteine ligase OS=Homo sapiens OX=9606 GN=PPCS PE=1 SV=2" "0.000" "False" "36.964" "32" "11" "13" "11" "311" "34.0" "6.71" "43.72" "11" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04127" "79717" "ENSG00000127125" "PPCS" "hsa:79717; Q3KQT2; Q5VVM0; Q9HAB8" "" "Coenzyme A biosynthesis" "1" "0" "0.961" "1.054" "0.882" "1.051" "0.952" "0.945" "0.977" "1.028" "0.747" "942.5" "905.7" "993.4" "831.5" "990.8" "897.1" "890.2" "921.0" "968.5" "704.2" "" "" "" "" "" "" "" "" "" "" "847.4" "732.9" "898.5" "811.7" "817.7" "897.1" "666.6" "813.5" "866.6" "251.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-843135532772952093" "False" "High" "IsMasterProtein" "Q8TD55" "Pleckstrin homology domain-containing family O member 2 OS=Homo sapiens OX=9606 GN=PLEKHO2 PE=1 SV=1" "0.000" "False" "36.961" "19" "9" "13" "9" "490" "53.3" "5.43" "48.23" "9" "other biological processes" "non-structural extracellular;other cell component" "" "Pf00169" "80301" "ENSG00000241839" "PLEKHO2" "hsa:80301; Q7L4H4; Q8TD55; Q8WYS8" "" "Neutrophil degranulation" "1" "0" "1.057" "1.014" "0.979" "1.039" "1.087" "1.032" "1.067" "1.106" "0.983" "1195.3" "1263.1" "1212.4" "1170.5" "1242.4" "1299.0" "1233.2" "1275.8" "1321.7" "1175.5" "" "" "" "" "" "" "" "" "" "" "1074.7" "1022.0" "1096.7" "1142.5" "1025.3" "1299.0" "923.4" "1126.9" "1182.7" "419.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8044840362148842225" "False" "High" "IsMasterProtein" "O95376" "E3 ubiquitin-protein ligase ARIH2 OS=Homo sapiens OX=9606 GN=ARIH2 PE=1 SV=1" "0.000" "False" "36.954" "21" "8" "14" "8" "493" "57.8" "5.63" "56.06" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01485, Pf19422" "10425" "ENSG00000177479" "ARIH2" "hsa:10425; O95376; Q9HBZ6; Q9UEM9" "Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.023" "0.962" "0.991" "1.079" "0.963" "0.985" "0.994" "0.970" "0.920" "518.0" "529.8" "498.4" "513.1" "558.8" "499.0" "510.3" "514.8" "502.3" "476.5" "" "" "" "" "" "" "" "" "" "" "465.7" "428.7" "450.8" "500.9" "461.1" "499.0" "382.1" "454.7" "449.5" "170.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4054510205684443302" "False" "High" "IsMasterProtein" "Q9Y6X8" "Zinc fingers and homeoboxes protein 2 OS=Homo sapiens OX=9606 GN=ZHX2 PE=1 SV=1" "0.000" "False" "36.921" "16" "11" "13" "11" "837" "92.3" "6.86" "42.78" "11" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf18387" "22882" "ENSG00000178764" "ZHX2" "hsa:22882; Q9Y6X8" "" "" "0" "0" "0.981" "0.994" "0.996" "1.065" "0.997" "1.037" "1.051" "1.001" "2.071" "793.1" "777.7" "788.1" "789.8" "844.5" "790.9" "822.5" "833.4" "793.7" "1643.0" "" "" "" "" "" "" "" "" "" "" "713.1" "629.3" "712.8" "771.0" "696.9" "790.9" "615.9" "736.1" "710.2" "586.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3114131480513419355" "False" "High" "IsMasterProtein" "P62701" "Small ribosomal subunit protein eS4, X isoform OS=Homo sapiens OX=9606 GN=RPS4X PE=1 SV=2" "0.000" "False" "36.877" "41" "10" "18" "10" "263" "29.6" "10.15" "59.70" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf00900, Pf08071, Pf16121" "6191" "ENSG00000198034" "RPS4X" "hsa:6191; P12631; P12750; P27576; P55831; P62701; Q14727; Q6IPY4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.020" "0.989" "0.914" "0.928" "1.036" "0.916" "0.933" "1.102" "1.185" "841.5" "858.1" "832.4" "768.8" "781.1" "871.6" "770.4" "785.3" "927.1" "996.9" "" "" "" "" "" "" "" "" "" "" "756.6" "694.4" "752.9" "750.5" "644.6" "871.6" "576.8" "693.6" "829.5" "355.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8029242028913948624" "False" "High" "IsMasterProtein" "Q92614" "Unconventional myosin-XVIIIa OS=Homo sapiens OX=9606 GN=MYO18A PE=1 SV=3" "0.000" "False" "36.849" "7" "12" "13" "12" "2054" "233.0" "6.30" "41.19" "12" "cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00063, Pf00595, Pf01576" "399687" "ENSG00000196535" "MYO18A" "hsa:399687; Q5H9U3; Q5QD01; Q5W9F9; Q5W9G1; Q8IXP8; Q92614" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "0.919" "0.895" "0.935" "0.924" "0.917" "0.943" "0.901" "0.931" "2.368" "1048.0" "963.1" "938.3" "979.9" "968.3" "961.0" "988.7" "943.9" "976.0" "2482.1" "" "" "" "" "" "" "" "" "" "" "942.3" "779.3" "848.7" "956.5" "799.1" "961.0" "740.4" "833.7" "873.3" "886.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7090269578477503572" "False" "High" "IsMasterProtein" "P29353" "SHC-transforming protein 1 OS=Homo sapiens OX=9606 GN=SHC1 PE=1 SV=4" "0.000" "False" "36.825" "21" "10" "14" "10" "583" "62.8" "6.44" "44.24" "10" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00640" "6464" "ENSG00000160691" "SHC1" "B5BU19; D3DV78; hsa:6464; O15290; P29353; Q5T180; Q5T183; Q5T184; Q5T185; Q5T186; Q8N4K5; Q96CL1" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; p38 MAPK signaling pathway; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Breast cancer pathway; EGF/EGFR signaling pathway; Fragile X syndrome; Gastrin signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; GDNF signaling; Macrophage-stimulating protein (MSP) signaling network map; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Tie2 Signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; Signaling by CSF3 (G-CSF); XBP1(S) activates chaperone genes; SHC1 events in EGFR signaling; Signaling by CSF1 (M-CSF) in myeloid cells; Integrin signaling; Erythropoietin activates RAS; Signalling to RAS; Signal attenuation; Interleukin-2 signaling; Interleukin-15 signaling" "65" "0" "1.040" "1.040" "1.016" "1.054" "1.020" "0.985" "1.085" "0.995" "0.908" "842.9" "876.8" "876.3" "856.6" "888.7" "860.0" "829.9" "914.7" "839.0" "765.7" "" "" "" "" "" "" "" "" "" "" "757.9" "709.5" "792.7" "836.2" "733.4" "860.0" "621.4" "808.0" "750.8" "273.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2101401554741180333" "False" "High" "IsMasterProtein" "Q8N5M1" "ATP synthase mitochondrial F1 complex assembly factor 2 OS=Homo sapiens OX=9606 GN=ATPAF2 PE=1 SV=1" "0.000" "False" "36.814" "31" "7" "11" "7" "289" "32.8" "7.09" "46.11" "7" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "" "Pf07542" "91647" "ENSG00000171953" "ATPAF2" "A6NDE5; A8K2J2; hsa:91647; Q6XYC7; Q8N5M1" "7q11.23 copy number variation syndrome; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.068" "1.053" "0.932" "1.031" "0.981" "1.065" "1.021" "1.064" "1.200" "698.7" "746.1" "735.7" "651.5" "720.2" "685.7" "743.9" "713.6" "743.6" "838.3" "" "" "" "" "" "" "" "" "" "" "628.2" "603.7" "665.4" "635.9" "594.3" "685.7" "557.0" "630.3" "665.4" "299.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575206036117319314" "False" "High" "IsMasterProtein" "Q9Y608" "Leucine-rich repeat flightless-interacting protein 2 OS=Homo sapiens OX=9606 GN=LRRFIP2 PE=1 SV=1" "0.000" "False" "36.804" "11" "7" "13" "5" "721" "82.1" "6.95" "50.34" "7" "cell-cell signaling;signal transduction;other biological processes" "" "other molecular function" "Pf09738" "9209" "ENSG00000093167" "LRRFIP2" "A8K649; A8MXR0; B4DY63; Q68CV3; Q9NXH5; Q9Y608" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.007" "1.119" "0.970" "1.016" "1.199" "1.018" "0.977" "1.150" "1.133" "465.9" "468.9" "521.3" "451.8" "473.3" "558.4" "474.1" "455.3" "536.0" "527.6" "" "" "" "" "" "" "" "" "" "" "418.9" "379.5" "471.5" "441.1" "390.6" "558.4" "355.0" "402.1" "479.6" "188.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7333180136300150104" "False" "High" "IsMasterProtein" "Q96S44" "EKC/KEOPS complex subunit TP53RK OS=Homo sapiens OX=9606 GN=TP53RK PE=1 SV=2" "0.000" "False" "36.793" "34" "7" "17" "7" "253" "28.1" "9.54" "64.31" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf06293" "112858" "ENSG00000172315" "TP53RK" "B3KU44; hsa:112858; Q3T977; Q5JZ01; Q6NZ60; Q96FM7; Q96S44; Q9NQE6" "" "tRNA modification in the nucleus and cytosol; Regulation of TP53 Activity through Phosphorylation" "2" "0" "1.046" "1.043" "1.083" "1.104" "1.007" "1.068" "1.025" "1.165" "1.199" "1024.0" "1070.9" "1067.8" "1108.7" "1130.9" "1031.4" "1093.2" "1049.5" "1192.7" "1227.6" "" "" "" "" "" "" "" "" "" "" "920.7" "866.5" "965.8" "1082.3" "933.2" "1031.4" "818.5" "927.0" "1067.2" "438.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4788954663334132438" "False" "High" "IsMasterProtein" "Q9NWX6" "Probable tRNA(His) guanylyltransferase OS=Homo sapiens OX=9606 GN=THG1L PE=1 SV=2" "0.000" "False" "36.790" "33" "9" "15" "9" "298" "34.8" "8.00" "50.21" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf04446, Pf14413" "54974" "ENSG00000113272" "THG1L" "D3DQJ5; hsa:54974; Q53G12; Q7L5R3; Q9H0S2; Q9NWX6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.986" "0.979" "0.963" "1.026" "0.931" "0.971" "0.978" "0.958" "0.858" "1269.7" "1251.7" "1242.6" "1223.3" "1303.2" "1182.0" "1232.7" "1241.7" "1216.7" "1089.4" "" "" "" "" "" "" "" "" "" "" "1141.6" "1012.8" "1124.0" "1194.2" "1075.5" "1182.0" "923.0" "1096.8" "1088.7" "388.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7489520263377738348" "False" "High" "IsMasterProtein" "Q96DI7" "U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens OX=9606 GN=SNRNP40 PE=1 SV=1" "0.000" "False" "36.779" "25" "7" "10" "7" "357" "39.3" "8.10" "49.02" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf00400" "9410" "ENSG00000060688" "SNRNP40" "B4DQJ1; hsa:9410; O75938; O95320; Q96DI7" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "0.973" "0.973" "0.931" "1.005" "0.989" "0.947" "0.935" "0.983" "0.881" "685.4" "667.2" "666.9" "638.4" "688.6" "677.6" "649.4" "640.7" "673.9" "603.8" "" "" "" "" "" "" "" "" "" "" "616.3" "539.9" "603.3" "623.2" "568.3" "677.6" "486.3" "565.9" "603.0" "215.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5749593247568362596" "False" "High" "IsMasterProtein" "Q9NYV4" "Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2" "0.000" "False" "36.762" "8" "9" "17" "7" "1490" "164.1" "9.44" "64.46" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "51755" "ENSG00000167258" "CDK12" "A7E2B2; B4DYX4; B9EIQ6; hsa:51755; O94978; Q9NYV4" "17q12 copy number variation syndrome" "TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "0.980" "0.936" "0.981" "1.032" "1.008" "1.064" "0.936" "0.963" "0.865" "647.1" "634.0" "605.9" "634.9" "667.8" "652.0" "688.2" "605.9" "622.8" "559.9" "" "" "" "" "" "" "" "" "" "" "581.8" "513.0" "548.1" "619.8" "551.1" "652.0" "515.3" "535.1" "557.3" "199.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3084200639085863850" "False" "High" "IsMasterProtein" "O14497" "AT-rich interactive domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ARID1A PE=1 SV=3" "0.000" "False" "36.762" "6" "10" "11" "9" "2285" "241.9" "6.70" "38.77" "10" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "8289" "ENSG00000117713" "ARID1A" "D3DPL1; hsa:8289; O14497; Q53FK9; Q5T0W1; Q5T0W2; Q5T0W3; Q8NFD6; Q96T89; Q9BY33; Q9HBJ5; Q9UPZ1" "Androgen receptor network in prostate cancer; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "7" "0" "0.870" "1.035" "0.917" "0.907" "0.896" "0.999" "0.928" "0.839" "1.838" "431.4" "375.2" "446.5" "395.5" "391.4" "386.6" "430.9" "400.4" "361.8" "792.9" "" "" "" "" "" "" "" "" "" "" "387.9" "303.6" "403.9" "386.1" "323.0" "386.6" "322.6" "353.7" "323.8" "283.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9023390433505774979" "False" "High" "IsMasterProtein" "P53597" "Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=SUCLG1 PE=1 SV=4" "0.000" "False" "36.754" "25" "7" "15" "7" "346" "36.2" "8.79" "56.20" "7" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00549, Pf02629" "8802" "ENSG00000163541" "SUCLG1" "hsa:8802; P53597; Q9BWB0; Q9UNP6" "Amino acid metabolism; TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle)" "3" "0" "0.999" "0.985" "0.987" "0.984" "0.963" "1.035" "1.020" "0.996" "0.890" "1935.1" "1933.1" "1906.2" "1910.3" "1904.9" "1863.9" "2002.4" "1974.6" "1927.4" "1722.4" "" "" "" "" "" "" "" "" "" "" "1739.8" "1564.2" "1724.2" "1864.7" "1572.0" "1863.9" "1499.3" "1744.1" "1724.6" "614.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1957491016862499710" "False" "High" "IsMasterProtein" "P13073" "Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens OX=9606 GN=COX4I1 PE=1 SV=1" "0.000" "False" "36.738" "29" "5" "13" "5" "169" "19.6" "9.51" "46.22" "5" "other metabolic processes;transport" "other membranes;cytosol;mitochondrion;nucleus" "transporter activity" "Pf02936" "1327" "ENSG00000131143" "COX4I1" "B2R4J2; D3DUM7; hsa:1327; P13073; Q6P666" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein degradation" "8" "0" "0.926" "0.914" "0.964" "0.944" "0.970" "0.912" "0.999" "0.934" "0.830" "1457.5" "1349.3" "1331.6" "1404.6" "1376.3" "1413.4" "1329.6" "1455.3" "1361.0" "1209.6" "" "" "" "" "" "" "" "" "" "" "1310.4" "1091.8" "1204.5" "1371.1" "1135.7" "1413.4" "995.5" "1285.4" "1217.8" "431.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7827642572833014462" "False" "High" "IsMasterProtein" "P14649" "Myosin light chain 6B OS=Homo sapiens OX=9606 GN=MYL6B PE=1 SV=1" "0.000" "False" "36.734" "39" "7" "21" "5" "208" "22.8" "5.73" "74.87" "7" "other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "" "140465" "ENSG00000196465" "MYL6B" "hsa:140465; P14649" "Ciliary landscape" "Smooth Muscle Contraction" "2" "0" "0.950" "1.095" "0.920" "0.973" "1.074" "0.993" "1.027" "1.066" "1.183" "269.1" "255.5" "294.6" "247.6" "261.9" "288.9" "267.1" "276.3" "286.9" "318.2" "" "" "" "" "" "" "" "" "" "" "241.9" "206.8" "266.5" "241.7" "216.1" "288.9" "200.0" "244.0" "256.7" "113.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "965973480370309944" "False" "High" "IsMasterProtein" "Q53HC9" "EARP and GARP complex-interacting protein 1 OS=Homo sapiens OX=9606 GN=EIPR1 PE=1 SV=2" "0.000" "False" "36.717" "34" "10" "13" "10" "387" "43.6" "5.06" "48.36" "10" "protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi" "" "Pf00400" "7260" "ENSG00000032389" "EIPR1" "D6W4Y1; hsa:7260; O43179; Q53HC9; Q53S19; Q53SG2" "Ciliary landscape" "" "1" "0" "1.009" "0.976" "0.954" "1.027" "0.935" "1.046" "0.998" "0.962" "0.987" "809.2" "816.3" "790.1" "771.7" "831.3" "756.8" "846.1" "807.5" "778.8" "798.4" "" "" "" "" "" "" "" "" "" "" "727.5" "660.6" "714.6" "753.3" "686.0" "756.8" "633.5" "713.3" "696.9" "285.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7606738261010209794" "False" "High" "IsMasterProtein" "Q7Z569" "BRCA1-associated protein OS=Homo sapiens OX=9606 GN=BRAP PE=1 SV=2" "0.000" "False" "36.705" "20" "9" "10" "9" "592" "67.3" "5.92" "40.41" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02148, Pf07576, Pf13639" "8315" "ENSG00000089234" "BRAP" "B4DRM1; B9EGS8; hsa:8315; O43238; O75341; Q7Z569" "Ras signaling" "RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Negative regulation of MAPK pathway" "6" "0" "1.020" "0.991" "0.936" "0.993" "1.026" "0.942" "1.028" "1.086" "1.885" "632.5" "645.4" "627.1" "592.3" "628.0" "649.2" "595.8" "650.2" "686.8" "1192.1" "" "" "" "" "" "" "" "" "" "" "568.7" "522.2" "567.2" "578.2" "518.3" "649.2" "446.2" "574.3" "614.5" "425.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-221730190353322517" "False" "High" "IsMasterProtein" "Q9UL63" "Muskelin OS=Homo sapiens OX=9606 GN=MKLN1 PE=1 SV=2" "0.000" "False" "36.693" "17" "9" "9" "9" "735" "84.7" "6.34" "39.28" "9" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf06588, Pf13415" "4289" "ENSG00000128585" "MKLN1" "A4D1M8; A6NG43; hsa:4289; Q9NSK4; Q9NUS8; Q9UL63" "Ciliary landscape" "" "1" "0" "1.103" "1.098" "0.986" "1.101" "1.083" "1.018" "1.080" "1.089" "0.837" "725.1" "800.2" "796.3" "715.0" "798.3" "785.3" "738.3" "783.1" "789.6" "606.8" "" "" "" "" "" "" "" "" "" "" "652.0" "647.5" "720.3" "698.0" "658.8" "785.3" "552.9" "691.7" "706.5" "216.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7162742285351111146" "False" "High" "IsMasterProtein" "Q13330" "Metastasis-associated protein MTA1 OS=Homo sapiens OX=9606 GN=MTA1 PE=1 SV=2" "0.000" "False" "36.673" "16" "10" "14" "7" "715" "80.7" "9.26" "46.50" "10" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf00320, Pf01426, Pf01448, Pf17226" "9112" "ENSG00000182979" "MTA1" "A5PLK4; hsa:9112; Q13330; Q86SW2; Q8NFI8; Q96GI8" "Effect of progerin on genes involved in progeria; TAR syndrome" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; SUMOylation of transcription factors" "8" "0" "1.130" "1.073" "1.035" "1.107" "1.085" "1.030" "1.027" "1.031" "1.406" "653.4" "738.5" "701.0" "676.5" "723.2" "709.1" "672.7" "671.2" "673.9" "918.7" "" "" "" "" "" "" "" "" "" "" "587.4" "597.5" "634.0" "660.3" "596.8" "709.1" "503.7" "592.8" "603.0" "327.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7585773354798248656" "False" "High" "IsMasterProtein" "O60232" "Protein ZNRD2 OS=Homo sapiens OX=9606 GN=ZNRD2 PE=1 SV=1" "0.000" "False" "36.653" "31" "5" "13" "5" "199" "21.5" "5.24" "60.08" "5" "cell cycle OR cell proliferation;other biological processes" "" "" "Pf06677" "10534" "ENSG00000173465" "ZNRD2" "hsa:10534; O60232" "" "" "0" "0" "0.917" "0.993" "0.934" "0.975" "1.010" "0.961" "0.997" "1.025" "0.832" "1438.0" "1319.1" "1427.7" "1343.2" "1401.6" "1453.0" "1382.0" "1433.1" "1474.1" "1196.4" "" "" "" "" "" "" "" "" "" "" "1292.9" "1067.3" "1291.4" "1311.1" "1156.6" "1453.0" "1034.8" "1265.8" "1319.0" "427.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4962513167934133051" "False" "High" "IsMasterProtein" "P49643" "DNA primase large subunit OS=Homo sapiens OX=9606 GN=PRIM2 PE=1 SV=2" "0.000" "False" "36.570" "21" "10" "10" "10" "509" "58.8" "7.91" "41.45" "10" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04104" "5558" "ENSG00000146143" "PRIM2" "hsa:5558; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413" "Pyrimidine metabolism; G1 to S cell cycle control; DNA replication" "Activation of the pre-replicative complex; Defective pyroptosis; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Polymerase switching on the C-strand of the telomere; Telomere C-strand synthesis initiation; DNA replication initiation; Polymerase switching; Removal of the Flap Intermediate" "12" "0" "1.005" "1.014" "1.045" "1.014" "0.935" "1.054" "1.037" "0.978" "1.537" "969.2" "974.1" "982.9" "1012.7" "982.8" "906.1" "1021.3" "1005.0" "948.1" "1489.8" "" "" "" "" "" "" "" "" "" "" "871.4" "788.2" "889.1" "988.5" "811.0" "906.1" "764.7" "887.6" "848.3" "531.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1363881983208351205" "False" "High" "IsMasterProtein" "Q15438" "Cytohesin-1 OS=Homo sapiens OX=9606 GN=CYTH1 PE=1 SV=1" "0.000" "False" "36.525" "28" "9" "10" "9" "398" "46.4" "5.54" "42.98" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01369" "9267" "ENSG00000108669" "CYTH1" "A6NFW7; B7Z1T4; hsa:9267; Q15438; Q9P123; Q9P124" "2q37 copy number variation syndrome" "Intra-Golgi traffic" "2" "0" "1.037" "1.035" "0.983" "1.056" "1.051" "1.005" "1.003" "1.085" "0.917" "829.3" "860.0" "858.1" "815.5" "875.7" "871.9" "833.5" "832.0" "899.5" "760.8" "" "" "" "" "" "" "" "" "" "" "745.6" "695.9" "776.2" "796.0" "722.7" "871.9" "624.1" "734.8" "804.9" "271.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5067244968494119358" "False" "High" "IsMasterProtein" "O75496" "Geminin OS=Homo sapiens OX=9606 GN=GMNN PE=1 SV=1" "0.000" "False" "36.473" "34" "6" "11" "6" "209" "23.6" "4.96" "37.71" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07412" "51053" "ENSG00000112312" "GMNN" "B3KMM8; hsa:51053; O75496; Q9H1Z1" "DNA replication; DYRK1A involvement regarding cell proliferation in brain development" "Assembly of the pre-replicative complex; Activation of the pre-replicative complex; Switching of origins to a post-replicative state" "5" "0" "0.947" "1.677" "0.932" "0.960" "1.712" "0.920" "0.980" "1.729" "1.002" "832.5" "788.3" "1396.3" "776.1" "799.4" "1425.0" "765.6" "815.6" "1439.6" "834.5" "" "" "" "" "" "" "" "" "" "" "748.5" "637.8" "1263.0" "757.6" "659.7" "1425.0" "573.3" "720.4" "1288.1" "297.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6527665309278316816" "False" "High" "IsMasterProtein" "O15145" "Actin-related protein 2/3 complex subunit 3 OS=Homo sapiens OX=9606 GN=ARPC3 PE=1 SV=3" "0.000" "False" "36.472" "37" "8" "22" "8" "178" "20.5" "8.59" "62.45" "8" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf04062" "10094" "ENSG00000111229" "ARPC3" "hsa:10094; O00554; O15145" "Pathogenic Escherichia coli infection" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; Clathrin-mediated endocytosis; EPHB-mediated forward signaling" "6" "0" "1.151" "0.988" "1.015" "0.939" "0.962" "0.979" "0.983" "0.964" "0.829" "1035.2" "1191.4" "1023.1" "1050.5" "971.5" "996.0" "1013.7" "1017.3" "998.3" "858.0" "" "" "" "" "" "" "" "" "" "" "930.7" "964.0" "925.5" "1025.4" "801.7" "996.0" "759.1" "898.5" "893.3" "306.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3428754804967895147" "False" "High" "IsMasterProtein" "O95989" "Diphosphoinositol polyphosphate phosphohydrolase 1 OS=Homo sapiens OX=9606 GN=NUDT3 PE=1 SV=1" "0.000" "False" "36.450" "40" "6" "11" "5" "172" "19.5" "6.34" "47.70" "6" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "11165" "ENSG00000272325" "NUDT3" "B2R8N4; hsa:11165; O95989" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "0.960" "0.971" "0.961" "0.989" "0.876" "0.999" "0.968" "0.940" "0.723" "1403.9" "1347.1" "1363.7" "1348.8" "1387.9" "1230.3" "1403.0" "1358.9" "1319.5" "1015.7" "" "" "" "" "" "" "" "" "" "" "1262.2" "1090.0" "1233.6" "1316.6" "1145.3" "1230.3" "1050.6" "1200.2" "1180.7" "362.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5240696879354608925" "False" "High" "IsMasterProtein" "Q8IUF1" "Zinc-regulated GTPase metalloprotein activator 1B OS=Homo sapiens OX=9606 GN=ZNG1B PE=1 SV=1" "0.000" "False" "36.403" "24" "7" "10" "7" "395" "44.0" "4.89" "39.16" "7" "" "nucleus;other cell component" "other molecular function" "Pf02492, Pf07683" "150472" "ENSG00000136682" "ZNG1B" "hsa:150472; Q0VAN3; Q8IUF1" "" "" "0" "0" "1.060" "1.149" "0.998" "1.069" "1.111" "1.145" "1.117" "1.248" "1.984" "448.2" "475.1" "515.1" "447.5" "478.9" "497.7" "513.0" "500.6" "559.2" "889.2" "" "" "" "" "" "" "" "" "" "" "402.9" "384.4" "466.0" "436.8" "395.2" "497.7" "384.1" "442.2" "500.4" "317.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2146106311129589736" "False" "High" "IsMasterProtein" "P35244" "Replication protein A 14 kDa subunit OS=Homo sapiens OX=9606 GN=RPA3 PE=1 SV=1" "0.000" "False" "36.398" "45" "4" "13" "4" "121" "13.6" "5.08" "52.15" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08661" "6119" "ENSG00000106399" "RPA3" "hsa:6119; P35244; Q549U6" "Retinoblastoma gene in cancer; G1 to S cell cycle control; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Fanconi Anemia Pathway; Regulation of HSF1-mediated heat shock response; Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Meiotic recombination; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; HSF1 activation; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Removal of the Flap Intermediate; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "36" "0" "1.043" "1.159" "0.969" "1.184" "1.076" "1.009" "1.096" "1.145" "1.092" "945.8" "986.4" "1096.5" "916.6" "1119.6" "1017.9" "954.0" "1036.5" "1083.1" "1032.4" "" "" "" "" "" "" "" "" "" "" "850.4" "798.1" "991.8" "894.8" "923.9" "1017.9" "714.3" "915.5" "969.2" "368.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8307908846177998742" "False" "High" "IsMasterProtein" "P20248" "Cyclin-A2 OS=Homo sapiens OX=9606 GN=CCNA2 PE=1 SV=2" "0.000" "False" "36.361" "26" "9" "13" "9" "432" "48.5" "6.54" "51.57" "9" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984, Pf16500" "890" "ENSG00000145386" "CCNA2" "A8K7B6; hsa:890; P20248; Q2M3U6; Q4W5P4; Q6LER8" "AMP-activated protein kinase signaling; Cell cycle; Retinoblastoma gene in cancer; Photodynamic therapy-induced AP-1 survival signaling; IL-18 signaling pathway; Acute myeloid leukemia; NF1 copy number variation syndrome" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; Regulation of TP53 Degradation; SCF(Skp2)-mediated degradation of p27/p21; Regulation of TP53 Activity through Phosphorylation; G2 Phase; Telomere Extension By Telomerase; Regulation of APC/C activators between G1/S and early anaphase; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1; Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes" "27" "0" "1.088" "1.440" "1.051" "1.099" "1.708" "1.053" "1.190" "1.488" "1.101" "546.0" "594.1" "786.0" "573.8" "599.8" "932.7" "574.9" "649.6" "812.2" "601.1" "" "" "" "" "" "" "" "" "" "" "490.9" "480.8" "711.0" "560.1" "495.0" "932.7" "430.5" "573.7" "726.7" "214.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3983028009750613022" "False" "High" "IsMasterProtein" "Q8N122" "Regulatory-associated protein of mTOR OS=Homo sapiens OX=9606 GN=RPTOR PE=1 SV=1" "0.000" "False" "36.335" "8" "9" "12" "9" "1335" "148.9" "6.89" "47.88" "9" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf02985, Pf14538" "57521" "ENSG00000141564" "RPTOR" "B2RN36; C6KEF2; F5H7J5; hsa:57521; Q8N122; Q8N4V9; Q8TB32; Q9P2P3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; CAMKK2 pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; Interferon type I signaling pathways" "mTORC1-mediated signalling; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; HSF1-dependent transactivation" "34" "0" "1.011" "0.960" "0.969" "0.980" "0.946" "0.996" "0.919" "0.935" "0.962" "757.2" "765.6" "727.0" "733.5" "741.7" "716.7" "754.0" "695.5" "707.7" "728.6" "" "" "" "" "" "" "" "" "" "" "680.8" "619.5" "657.6" "716.0" "612.0" "716.7" "564.5" "614.3" "633.2" "260.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5454865549219062540" "False" "High" "IsMasterProtein" "P14859" "POU domain, class 2, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU2F1 PE=1 SV=2" "0.000" "False" "36.312" "12" "6" "10" "6" "743" "76.4" "6.81" "48.90" "6" "other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157, Pf19536" "5451" "ENSG00000143190" "POU2F1" "B1AL91; B1AL93; B4E029; hsa:5451; J3KP77; P14859; Q5TBT7; Q6PK46; Q8NEU9; Q9BPV1" "Integrated cancer pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Interleukin-4 and Interleukin-13 signaling" "6" "0" "0.967" "0.898" "1.030" "1.015" "0.925" "1.045" "1.003" "0.956" "2.307" "453.4" "438.4" "407.2" "466.8" "460.2" "419.3" "473.8" "454.6" "433.3" "1045.9" "" "" "" "" "" "" "" "" "" "" "407.7" "354.7" "368.3" "455.7" "379.8" "419.3" "354.8" "401.5" "387.7" "373.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825408205880823904" "False" "High" "IsMasterProtein" "P14635" "G2/mitotic-specific cyclin-B1 OS=Homo sapiens OX=9606 GN=CCNB1 PE=1 SV=1" "0.000" "False" "36.265" "23" "8" "12" "8" "433" "48.3" "7.47" "48.01" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "891" "ENSG00000134057" "CCNB1" "A8K066; hsa:891; P14635; Q5TZP9" "AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; ATM signaling pathway; G1 to S cell cycle control; GDNF signaling; IL-19 signaling pathway; DNA damage response" "The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of the APC/C; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Cyclin A/B1/B2 associated events during G2/M transition; Transcriptional regulation by RUNX2; MASTL Facilitates Mitotic Progression; E2F-enabled inhibition of pre-replication complex formation; Golgi Cisternae Pericentriolar Stack Reorganization; Condensation of Prophase Chromosomes; Initiation of Nuclear Envelope (NE) Reformation; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint; Depolymerization of the Nuclear Lamina; Nuclear events stimulated by ALK signaling in cancer; Phosphorylation of Emi1" "33" "0" "1.013" "1.477" "1.031" "0.981" "1.401" "1.021" "1.000" "1.409" "0.969" "1360.7" "1378.6" "2010.3" "1402.6" "1335.4" "1906.5" "1389.7" "1361.0" "1916.6" "1318.5" "" "" "" "" "" "" "" "" "" "" "1223.4" "1115.5" "1818.3" "1369.2" "1102.0" "1906.5" "1040.5" "1202.1" "1715.0" "470.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014625147701874173" "False" "High" "IsMasterProtein" "Q5T160" "Probable arginine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=RARS2 PE=1 SV=1" "0.000" "False" "36.247" "22" "12" "12" "12" "578" "65.5" "8.21" "40.00" "12" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00750, Pf05746" "57038" "ENSG00000146282" "RARS2" "B2RDT7; hsa:57038; Q5T160; Q96FU5; Q9H8K8" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.006" "1.030" "0.947" "1.022" "1.054" "0.996" "0.997" "0.978" "0.940" "927.1" "932.8" "954.9" "878.4" "947.7" "977.1" "923.8" "924.6" "906.4" "871.2" "" "" "" "" "" "" "" "" "" "" "833.6" "754.8" "863.7" "857.4" "782.1" "977.1" "691.7" "816.6" "811.0" "311.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6698557715673705148" "False" "High" "IsMasterProtein" "Q6P3W7" "SCY1-like protein 2 OS=Homo sapiens OX=9606 GN=SCYL2 PE=1 SV=1" "0.000" "False" "36.204" "15" "12" "12" "12" "929" "103.6" "8.22" "44.44" "12" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069" "55681" "ENSG00000136021" "SCYL2" "A8KAB5; hsa:55681; Q6P3W7; Q96EF4; Q96ST4; Q9H7V5; Q9NVH3; Q9P2I7" "" "" "0" "0" "1.010" "0.994" "0.989" "1.037" "0.998" "0.996" "0.993" "1.032" "0.870" "829.5" "837.5" "824.8" "820.3" "860.0" "828.1" "826.3" "823.7" "855.9" "721.5" "" "" "" "" "" "" "" "" "" "" "745.8" "677.6" "746.1" "800.7" "709.7" "828.1" "618.7" "727.5" "765.9" "257.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8714366505281620526" "False" "High" "IsMasterProtein" "Q7L5Y9" "E3 ubiquitin-protein transferase MAEA OS=Homo sapiens OX=9606 GN=MAEA PE=1 SV=1" "0.000" "False" "36.130" "24" "9" "10" "9" "396" "45.3" "8.69" "42.26" "9" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10607" "10296" "ENSG00000090316" "MAEA" "hsa:10296; O95285; Q5JB54; Q6ZRD6; Q7L5Y9; Q9BQ11; Q9H9V6; Q9H9Z4; Q9NW84" "Ciliary landscape" "" "1" "0" "1.060" "1.047" "0.955" "1.002" "0.990" "0.951" "1.002" "1.071" "0.893" "1346.8" "1428.0" "1410.1" "1285.5" "1349.5" "1333.1" "1281.1" "1349.2" "1441.7" "1202.9" "" "" "" "" "" "" "" "" "" "" "1210.9" "1155.5" "1275.4" "1254.8" "1113.6" "1333.1" "959.2" "1191.7" "1290.1" "429.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5046480723636324863" "False" "High" "IsMasterProtein" "Q9Y314" "Nitric oxide synthase-interacting protein OS=Homo sapiens OX=9606 GN=NOSIP PE=1 SV=1" "0.000" "False" "36.066" "31" "9" "12" "9" "301" "33.2" "8.82" "49.83" "9" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf15906" "51070" "ENSG00000142546" "NOSIP" "Q96FD2; Q9Y314" "" "NOSIP mediated eNOS trafficking" "1" "0" "1.043" "1.136" "1.051" "1.042" "1.102" "0.970" "1.081" "1.228" "1.344" "1154.3" "1203.8" "1311.0" "1213.0" "1203.2" "1272.0" "1119.3" "1247.3" "1417.2" "1551.4" "" "" "" "" "" "" "" "" "" "" "1037.9" "974.1" "1185.8" "1184.1" "992.9" "1272.0" "838.1" "1101.7" "1268.1" "553.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1511141278890819027" "False" "High" "IsMasterProtein" "O14802" "DNA-directed RNA polymerase III subunit RPC1 OS=Homo sapiens OX=9606 GN=POLR3A PE=1 SV=2" "0.000" "False" "36.065" "10" "13" "13" "13" "1390" "155.5" "8.48" "36.74" "13" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00623, Pf04983, Pf04997, Pf04998, Pf05000" "11128" "ENSG00000148606" "POLR3A" "hsa:11128; O14802; Q8IW34; Q8TCW5" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "9" "0" "0.942" "0.996" "0.950" "0.945" "0.947" "1.003" "0.928" "0.904" "1.494" "871.8" "821.0" "868.0" "828.0" "823.6" "825.2" "874.5" "808.9" "788.0" "1302.7" "" "" "" "" "" "" "" "" "" "" "783.8" "664.3" "785.1" "808.3" "679.6" "825.2" "654.8" "714.5" "705.1" "465.0" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7098201232450387464" "False" "High" "IsMasterProtein" "Q8N999" "RNA ligase 1 OS=Homo sapiens OX=9606 GN=RLIG1 PE=1 SV=2" "0.000" "False" "36.029" "25" "9" "15" "9" "325" "37.5" "7.06" "50.23" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "" "other molecular function" "Pf17720" "91298" "ENSG00000133641" "RLIG1" "Q569K5; Q6AWA8; Q6PEK5; Q8IYQ5; Q8N999; Q9NT75" "" "" "0" "0" "0.969" "1.003" "1.010" "1.020" "1.014" "0.961" "1.013" "1.006" "0.830" "1624.2" "1573.3" "1628.4" "1640.8" "1656.8" "1647.5" "1560.9" "1644.5" "1634.4" "1348.6" "" "" "" "" "" "" "" "" "" "" "1460.3" "1273.0" "1473.0" "1601.6" "1367.3" "1647.5" "1168.8" "1452.5" "1462.4" "481.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485844677282632680" "False" "High" "IsMasterProtein" "Q99717" "Mothers against decapentaplegic homolog 5 OS=Homo sapiens OX=9606 GN=SMAD5 PE=1 SV=1" "0.000" "False" "36.011" "18" "8" "12" "7" "465" "52.2" "7.71" "45.79" "8" "developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4090" "ENSG00000113658" "SMAD5" "hsa:4090; O14688; Q15798; Q99717; Q9UQA1" "Differentiation of white and brown adipocyte; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; BMP signaling in eyelid development; Embryonic stem cell pluripotency pathways; Neovascularization processes; Osteoblast differentiation and related diseases; TGF-beta receptor signaling in skeletal dysplasias; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling" "Signaling by BMP" "14" "0" "1.041" "1.072" "1.096" "0.986" "1.028" "1.074" "1.095" "1.056" "1.148" "518.2" "539.6" "555.5" "568.0" "510.8" "532.5" "556.5" "567.4" "547.0" "595.0" "" "" "" "" "" "" "" "" "" "" "465.9" "436.7" "502.5" "554.5" "421.5" "532.5" "416.7" "501.2" "489.5" "212.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991107467839093977" "False" "High" "IsMasterProtein" "Q99747" "Gamma-soluble NSF attachment protein OS=Homo sapiens OX=9606 GN=NAPG PE=1 SV=1" "0.000" "False" "35.958" "25" "8" "12" "8" "312" "34.7" "5.41" "42.21" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf14938" "8774" "ENSG00000134265" "NAPG" "B4DFC9; hsa:8774; Q99747; Q9BUV1" "" "Retrograde transport at the Trans-Golgi-Network; COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; COPII-mediated vesicle transport; Intra-Golgi traffic" "5" "0" "0.892" "0.953" "0.969" "0.918" "0.924" "0.947" "0.925" "0.985" "1.814" "1089.4" "971.8" "1038.0" "1055.3" "1000.2" "1006.1" "1031.3" "1007.3" "1073.5" "1976.0" "" "" "" "" "" "" "" "" "" "" "979.5" "786.4" "938.9" "1030.1" "825.4" "1006.1" "772.2" "889.7" "960.5" "705.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7828842707520281021" "False" "High" "IsMasterProtein" "P41223" "Protein BUD31 homolog OS=Homo sapiens OX=9606 GN=BUD31 PE=1 SV=2" "0.000" "False" "35.956" "55" "9" "17" "9" "144" "17.0" "8.82" "58.89" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01125" "8896" "ENSG00000106245" "BUD31" "A4D274; B7Z4S9; D6W5S6; hsa:8896; P41223; Q6IB53; Q9UDV1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.932" "0.998" "0.930" "0.967" "1.046" "1.037" "1.046" "1.027" "0.799" "1032.5" "962.3" "1030.6" "960.1" "998.3" "1079.9" "1070.3" "1080.4" "1060.4" "825.3" "" "" "" "" "" "" "" "" "" "" "928.3" "778.7" "932.2" "937.2" "823.8" "1079.9" "801.4" "954.2" "948.8" "294.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7643769137675685694" "False" "High" "IsMasterProtein" "P82933" "Small ribosomal subunit protein uS9m OS=Homo sapiens OX=9606 GN=MRPS9 PE=1 SV=2" "0.000" "False" "35.943" "25" "10" "12" "10" "396" "45.8" "9.51" "42.91" "10" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00380" "64965" "ENSG00000135972" "MRPS9" "hsa:64965; P82933; Q6PG40" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.947" "0.901" "0.984" "0.901" "0.867" "1.003" "0.889" "0.899" "1.392" "905.5" "857.8" "815.8" "891.2" "815.9" "785.5" "908.2" "804.6" "814.4" "1260.6" "" "" "" "" "" "" "" "" "" "" "814.2" "694.1" "737.9" "870.0" "673.3" "785.5" "680.0" "710.7" "728.7" "450.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6335847497915133656" "False" "High" "IsMasterProtein" "Q9BTY7" "Protein HGH1 homolog OS=Homo sapiens OX=9606 GN=HGH1 PE=1 SV=1" "0.000" "False" "35.942" "37" "11" "13" "11" "390" "42.1" "4.81" "39.66" "11" "" "" "" "Pf04063, Pf04064" "51236" "ENSG00000235173" "HGH1" "hsa:51236; P0CB43; Q9BTY7" "" "" "0" "0" "1.046" "0.956" "1.017" "1.055" "1.038" "1.062" "1.012" "1.012" "2.352" "930.0" "972.3" "888.9" "945.3" "980.7" "965.0" "987.4" "941.5" "941.5" "2187.3" "" "" "" "" "" "" "" "" "" "" "836.1" "786.8" "804.0" "922.8" "809.3" "965.0" "739.3" "831.6" "842.4" "780.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5055182102876441761" "False" "High" "IsMasterProtein" "Q9BRT9" "DNA replication complex GINS protein SLD5 OS=Homo sapiens OX=9606 GN=GINS4 PE=1 SV=1" "0.000" "False" "35.927" "45" "9" "19" "9" "223" "26.0" "4.98" "66.20" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf05916, Pf16922" "84296" "ENSG00000147536" "GINS4" "B2R8H5; D3DSY0; hsa:84296; Q8N648; Q9BRT9" "" "Unwinding of DNA" "1" "0" "0.978" "1.017" "1.013" "1.022" "1.037" "1.022" "0.978" "1.012" "1.069" "948.2" "927.2" "963.9" "960.4" "968.8" "983.7" "969.4" "927.4" "959.8" "1014.0" "" "" "" "" "" "" "" "" "" "" "852.5" "750.3" "871.9" "937.5" "799.5" "983.7" "725.9" "819.1" "858.8" "362.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1178646061152564690" "False" "High" "IsMasterProtein" "P40938" "Replication factor C subunit 3 OS=Homo sapiens OX=9606 GN=RFC3 PE=1 SV=2" "0.000" "False" "35.884" "30" "8" "10" "8" "356" "40.5" "8.34" "38.80" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13177" "5983" "ENSG00000133119" "RFC3" "C9JU95; hsa:5983; O15252; P40938; Q5W0E8" "Gastric cancer network 2; Retinoblastoma gene in cancer; DNA replication; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "28" "0" "0.994" "1.033" "0.966" "0.957" "1.029" "0.976" "0.953" "1.061" "1.080" "654.9" "651.0" "676.5" "632.5" "627.0" "674.1" "639.2" "624.3" "694.8" "707.5" "" "" "" "" "" "" "" "" "" "" "588.8" "526.8" "611.9" "617.4" "517.4" "674.1" "478.6" "551.5" "621.7" "252.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625848183831329232" "False" "High" "IsMasterProtein" "Q6VMQ6" "Activating transcription factor 7-interacting protein 1 OS=Homo sapiens OX=9606 GN=ATF7IP PE=1 SV=3" "0.000" "False" "35.845" "10" "8" "9" "8" "1270" "136.3" "4.70" "34.91" "8" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf16788, Pf16794" "55729" "ENSG00000171681" "ATF7IP" "F5GX74; G3V1U0; hsa:55729; Q4G0T9; Q6P3T3; Q6VMQ6; Q86XW5; Q9NVJ9; Q9NWC2; Q9Y4X8" "" "PKMTs methylate histone lysines" "1" "0" "1.023" "0.948" "1.004" "1.033" "0.938" "1.162" "1.035" "0.896" "1.862" "675.1" "690.6" "640.1" "677.6" "697.4" "633.3" "784.6" "698.4" "605.1" "1257.3" "" "" "" "" "" "" "" "" "" "" "607.0" "558.8" "579.0" "661.4" "575.5" "633.3" "587.5" "616.9" "541.4" "448.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590032029601755120" "False" "High" "IsMasterProtein" "O75935" "Dynactin subunit 3 OS=Homo sapiens OX=9606 GN=DCTN3 PE=1 SV=1" "0.000" "False" "35.796" "42" "9" "13" "9" "186" "21.1" "5.47" "49.89" "9" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07426" "11258" "ENSG00000137100" "DCTN3" "A6NII7; B2RBM5; hsa:11258; O75935; Q5T1I5; Q5T1I7; Q5T8G3; Q9BPU8" "" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; Recruitment of NuMA to mitotic centrosomes; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "11" "0" "0.999" "1.030" "1.038" "1.029" "0.968" "1.054" "1.021" "1.048" "0.995" "2034.9" "2032.8" "2096.7" "2111.4" "2094.1" "1969.8" "2145.6" "2077.8" "2132.2" "2024.2" "" "" "" "" "" "" "" "" "" "" "1829.6" "1644.8" "1896.6" "2061.0" "1728.1" "1969.8" "1606.6" "1835.2" "1907.9" "722.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5808192534094495875" "False" "High" "IsMasterProtein" "Q9HC35" "Echinoderm microtubule-associated protein-like 4 OS=Homo sapiens OX=9606 GN=EML4 PE=1 SV=3" "0.000" "False" "35.794" "13" "11" "12" "11" "981" "108.8" "6.40" "41.06" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "27436" "ENSG00000143924" "EML4" "A6H8Y6; A6P4T4; A6P4V4; B2RBK3; B2RTW7; B5MCW9; hsa:27436; Q3SWW0; Q53R29; Q53TW8; Q6PJ45; Q9HC35; Q9NV40" "Non-small cell lung cancer" "EML4 and NUDC in mitotic spindle formation; ALK mutants bind TKIs; Signaling by ALK fusions and activated point mutants" "4" "0" "0.964" "1.014" "0.975" "0.941" "0.919" "0.961" "0.887" "0.986" "2.061" "1078.5" "1039.7" "1093.6" "1051.0" "1014.4" "991.5" "1036.4" "956.4" "1063.8" "2223.0" "" "" "" "" "" "" "" "" "" "" "969.6" "841.3" "989.2" "1025.9" "837.1" "991.5" "776.1" "844.7" "951.9" "793.6" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8542796064985296864" "False" "High" "IsMasterProtein" "Q969Y2" "tRNA modification GTPase GTPBP3, mitochondrial OS=Homo sapiens OX=9606 GN=GTPBP3 PE=1 SV=2" "0.000" "False" "35.788" "21" "8" "10" "8" "492" "52.0" "6.48" "41.56" "8" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01926, Pf10396, Pf12631" "84705" "ENSG00000130299" "GTPBP3" "A6NFH1; A6NIG5; A6NKR4; A8K7B4; B7Z4V8; hsa:84705; Q8TCY6; Q8WUW9; Q969G4; Q969Y2; Q9BX61" "" "tRNA modification in the mitochondrion" "1" "0" "1.006" "0.994" "0.920" "1.022" "0.954" "0.919" "0.994" "0.936" "0.915" "718.7" "722.8" "714.1" "661.4" "734.2" "686.0" "660.2" "714.1" "673.0" "657.9" "" "" "" "" "" "" "" "" "" "" "646.2" "584.9" "646.0" "645.7" "605.9" "686.0" "494.4" "630.7" "602.2" "234.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8862135404577219062" "False" "High" "IsMasterProtein" "Q9UJZ1" "Stomatin-like protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=STOML2 PE=1 SV=1" "0.000" "False" "35.763" "27" "7" "11" "7" "356" "38.5" "7.39" "45.51" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf01145, Pf16200" "30968" "ENSG00000165283" "STOML2" "B4E1K7; D3DRN3; hsa:30968; O60376; Q53G29; Q96FY2; Q9P042; Q9UJZ1" "" "Processing of SMDT1; Cellular response to mitochondrial stress" "2" "0" "1.011" "1.082" "0.972" "1.107" "1.071" "1.041" "1.090" "1.016" "0.980" "1028.3" "1039.6" "1112.2" "999.4" "1137.9" "1101.6" "1070.1" "1121.0" "1044.7" "1007.5" "" "" "" "" "" "" "" "" "" "" "924.5" "841.2" "1006.1" "975.5" "939.0" "1101.6" "801.3" "990.1" "934.8" "359.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6462118287367883221" "False" "High" "IsMasterProtein" "Q9Y296" "Trafficking protein particle complex subunit 4 OS=Homo sapiens OX=9606 GN=TRAPPC4 PE=1 SV=1" "0.000" "False" "35.736" "43" "9" "13" "9" "219" "24.3" "6.21" "49.59" "9" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "51399" "ENSG00000196655; ENSG00000280495" "TRAPPC4" "A8K3A5; B4DME1; hsa:51399; Q9Y296" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport; Syndecan interactions" "3" "0" "0.981" "1.033" "0.974" "1.014" "1.024" "0.960" "1.013" "1.021" "1.221" "794.9" "779.9" "821.1" "774.1" "806.2" "814.3" "763.1" "805.5" "811.6" "970.3" "" "" "" "" "" "" "" "" "" "" "714.7" "631.1" "742.8" "755.6" "665.3" "814.3" "571.4" "711.4" "726.2" "346.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849242953917426165" "False" "High" "IsMasterProtein" "Q9HCD5" "Nuclear receptor coactivator 5 OS=Homo sapiens OX=9606 GN=NCOA5 PE=1 SV=2" "0.000" "False" "35.736" "19" "11" "12" "11" "579" "65.5" "9.60" "39.60" "11" "signal transduction;other biological processes" "cytoskeleton;nucleus" "other molecular function" "" "57727" "ENSG00000124160" "NCOA5" "B2RTV9; E1P5R0; Q6HA99; Q9H1F2; Q9H2T2; Q9H4Y9; Q9HCD5" "" "" "0" "0" "0.959" "0.954" "0.988" "0.995" "1.003" "0.917" "1.001" "0.991" "0.948" "764.7" "733.2" "729.5" "755.5" "760.9" "766.7" "701.4" "765.8" "757.8" "724.6" "" "" "" "" "" "" "" "" "" "" "687.6" "593.3" "659.9" "737.4" "627.9" "766.7" "525.2" "676.4" "678.1" "258.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8154313858001218704" "False" "High" "IsMasterProtein" "Q8IWZ3" "Ankyrin repeat and KH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKHD1 PE=1 SV=1" "0.000" "False" "35.728" "5" "11" "12" "3" "2542" "269.3" "5.73" "44.00" "11" "stress response" "other cell component" "" "Pf00013, Pf12796, Pf13637" "404734; 54882" "ENSG00000131503" "ANKHD1" "A6NH85; hsa:404734; hsa:54882; Q149P2; Q8IWZ2; Q8IWZ3; Q8WY90; Q96G77; Q96GK0; Q9H2U0; Q9HA95; Q9NWG4; Q9UPR7" "" "" "0" "0" "1.018" "1.091" "0.976" "1.090" "1.062" "1.089" "0.964" "1.132" "6.068" "217.9" "221.7" "237.6" "212.7" "237.5" "231.3" "237.3" "210.0" "246.7" "1321.9" "" "" "" "" "" "" "" "" "" "" "195.9" "179.4" "214.9" "207.6" "196.0" "231.3" "177.7" "185.5" "220.8" "471.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209477172492729631" "False" "High" "IsMasterProtein" "Q9UPN6" "SR-related and CTD-associated factor 8 OS=Homo sapiens OX=9606 GN=SCAF8 PE=1 SV=1" "0.000" "False" "35.690" "12" "12" "13" "9" "1271" "140.4" "8.29" "41.66" "12" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf04818" "22828" "ENSG00000213079" "SCAF8" "B7Z888; hsa:22828; Q5TBU6; Q6NSK3; Q9BQN8; Q9BX43; Q9UPN6" "" "" "0" "0" "1.115" "1.038" "1.052" "0.990" "1.055" "1.189" "0.999" "0.990" "2.325" "431.6" "481.0" "448.1" "454.2" "427.3" "455.4" "513.3" "431.1" "427.2" "1003.3" "" "" "" "" "" "" "" "" "" "" "388.1" "389.2" "405.3" "443.3" "352.6" "455.4" "384.4" "380.8" "382.2" "358.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943228809179220327" "False" "High" "IsMasterProtein" "Q8IWX8" "Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens OX=9606 GN=CHERP PE=1 SV=3" "0.000" "False" "35.677" "10" "10" "13" "10" "916" "103.6" "9.04" "40.10" "10" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01585, Pf01805, Pf04818" "10523" "ENSG00000085872" "CHERP" "hsa:10523; O00302; Q4G0Y5; Q8IWX8; Q8WU30; Q99492" "" "mRNA Splicing - Major Pathway" "1" "0" "0.960" "0.980" "0.878" "0.955" "1.095" "0.985" "0.872" "0.878" "1.290" "424.6" "407.6" "416.1" "372.7" "405.6" "464.9" "418.1" "370.4" "372.7" "547.9" "" "" "" "" "" "" "" "" "" "" "381.8" "329.8" "376.3" "363.8" "334.7" "464.9" "313.1" "327.2" "333.5" "195.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7131720843867798084" "False" "High" "IsMasterProtein" "Q9BT09" "Protein canopy homolog 3 OS=Homo sapiens OX=9606 GN=CNPY3 PE=1 SV=1" "0.000" "False" "35.652" "33" "9" "11" "9" "278" "30.7" "5.49" "46.35" "9" "stress response" "ER/Golgi" "signal transduction activity or receptor binding" "Pf11938" "10695" "ENSG00000137161" "CNPY3" "hsa:10695; O15412; Q0P6I2; Q8NF54; Q8WTU8; Q9BT09; Q9P0F2" "" "Trafficking and processing of endosomal TLR" "1" "0" "0.878" "0.913" "0.922" "0.993" "0.946" "0.991" "0.969" "0.982" "0.738" "1693.1" "1486.4" "1546.2" "1560.6" "1681.6" "1601.9" "1677.3" "1640.3" "1663.4" "1248.8" "" "" "" "" "" "" "" "" "" "" "1522.3" "1202.7" "1398.6" "1523.4" "1387.6" "1601.9" "1255.9" "1448.9" "1488.4" "445.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1018884242771776576" "False" "High" "IsMasterProtein" "P30048" "Thioredoxin-dependent peroxide reductase, mitochondrial OS=Homo sapiens OX=9606 GN=PRDX3 PE=1 SV=3" "0.000" "False" "35.642" "25" "7" "27" "7" "256" "27.7" "7.78" "91.00" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00578, Pf10417" "10935" "ENSG00000165672" "PRDX3" "B2R7Z0; D3DRC9; E9PH29; hsa:10935; P30048; P35690; Q0D2H1; Q13776; Q5T5V2; Q96HK4" "Selenium micronutrient network" "Detoxification of Reactive Oxygen Species" "2" "0" "1.070" "1.048" "1.017" "1.046" "1.000" "1.006" "1.049" "1.062" "0.809" "2345.1" "2509.3" "2457.7" "2385.0" "2453.2" "2345.5" "2358.5" "2459.5" "2490.6" "1897.8" "" "" "" "" "" "" "" "" "" "" "2108.5" "2030.4" "2223.1" "2328.1" "2024.5" "2345.5" "1766.0" "2172.4" "2228.5" "677.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6512701136026714686" "False" "High" "IsMasterProtein" "O95379" "Tumor necrosis factor alpha-induced protein 8 OS=Homo sapiens OX=9606 GN=TNFAIP8 PE=1 SV=1" "0.000" "False" "35.615" "34" "6" "15" "6" "198" "23.0" "7.93" "51.07" "6" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05527" "25816" "ENSG00000145779" "TNFAIP8" "B3KMH1; B3KMI2; B7Z713; hsa:25816; O95379; Q9P1Q1; Q9UER5; Q9UP47" "" "PI Metabolism" "1" "0" "1.004" "1.036" "0.948" "1.083" "0.950" "1.044" "0.993" "0.994" "0.865" "1444.0" "1449.6" "1496.1" "1369.3" "1563.2" "1372.4" "1507.4" "1433.9" "1436.0" "1249.7" "" "" "" "" "" "" "" "" "" "" "1298.3" "1172.9" "1353.3" "1336.6" "1290.0" "1372.4" "1128.7" "1266.5" "1284.9" "446.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2529735565303520700" "False" "High" "IsMasterProtein" "Q9BQS8" "FYVE and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FYCO1 PE=1 SV=3" "0.000" "False" "35.599" "8" "10" "13" "9" "1478" "166.9" "4.92" "43.91" "10" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf02759" "79443" "ENSG00000163820" "FYCO1" "B7ZKT7; hsa:79443; Q3MJE6; Q86T41; Q86TB1; Q8TEF9; Q96IV5; Q9BQS8; Q9H8P9" "Clock-controlled autophagy in bone metabolism" "" "1" "0" "1.014" "0.937" "0.948" "0.988" "0.968" "0.999" "1.035" "0.962" "1.277" "314.6" "319.0" "294.8" "298.2" "310.8" "304.6" "314.4" "325.6" "302.8" "401.6" "" "" "" "" "" "" "" "" "" "" "282.9" "258.1" "266.6" "291.1" "256.5" "304.6" "235.4" "287.6" "270.9" "143.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507762156530799771" "False" "High" "IsMasterProtein" "O43670" "BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Homo sapiens OX=9606 GN=ZNF207 PE=1 SV=1" "0.000" "False" "35.593" "15" "6" "13" "6" "478" "50.7" "9.10" "50.87" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "" "7756" "ENSG00000010244" "ZNF207" "A8K6Y6; E1P660; E1P661; E1P662; hsa:7756; O43670; Q53XS9; Q96HW5; Q9BUQ7" "" "" "0" "0" "0.950" "0.942" "1.013" "0.957" "0.946" "0.967" "0.959" "0.920" "0.714" "1214.5" "1153.9" "1143.8" "1230.2" "1162.9" "1149.0" "1174.5" "1165.2" "1117.6" "867.1" "" "" "" "" "" "" "" "" "" "" "1092.0" "933.7" "1034.6" "1200.9" "959.6" "1149.0" "879.5" "1029.2" "1000.1" "309.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5439043522832827691" "False" "High" "IsMasterProtein" "Q8WZA0" "Protein LZIC OS=Homo sapiens OX=9606 GN=LZIC PE=1 SV=1" "0.000" "False" "35.589" "36" "8" "15" "8" "190" "21.5" "4.94" "53.80" "8" "other biological processes" "" "other molecular function" "Pf06384" "84328" "ENSG00000162441" "LZIC" "B2R6F0; B4E2N0; hsa:84328; Q8WZA0; Q96IU1" "" "" "0" "0" "0.918" "0.888" "0.938" "1.002" "0.894" "0.975" "1.008" "0.965" "0.740" "1341.1" "1231.2" "1191.1" "1257.9" "1343.5" "1198.7" "1308.2" "1351.2" "1293.5" "991.8" "" "" "" "" "" "" "" "" "" "" "1205.8" "996.3" "1077.4" "1227.9" "1108.7" "1198.7" "979.6" "1193.5" "1157.4" "354.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7356302297912569782" "False" "High" "IsMasterProtein" "O75400" "Pre-mRNA-processing factor 40 homolog A OS=Homo sapiens OX=9606 GN=PRPF40A PE=1 SV=2" "0.000" "False" "35.554" "12" "10" "11" "10" "957" "108.7" "7.56" "39.43" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf00397, Pf01846" "55660" "ENSG00000196504" "PRPF40A" "hsa:55660; O43856; O75400; O75404; Q8TBQ1; Q9H782; Q9NWU9; Q9P0Q2; Q9Y5A8" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.979" "0.929" "0.949" "0.958" "1.018" "0.974" "0.915" "1.014" "1.248" "793.6" "776.5" "737.5" "753.4" "760.3" "808.0" "772.9" "726.4" "804.8" "990.1" "" "" "" "" "" "" "" "" "" "" "713.5" "628.4" "667.1" "735.4" "627.4" "808.0" "578.8" "641.6" "720.1" "353.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5778501702482241288" "False" "High" "IsMasterProtein" "P41182" "B-cell lymphoma 6 protein OS=Homo sapiens OX=9606 GN=BCL6 PE=1 SV=1" "0.000" "False" "35.513" "14" "10" "13" "10" "706" "78.8" "7.94" "50.09" "10" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "604" "ENSG00000113916" "BCL6" "A7E241; B8PSA7; D3DNV5; hsa:604; P41182" "B cell receptor signaling pathway; Vitamin D receptor pathway; MECP2 and associated Rett syndrome; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Extrafollicular and follicular B cell activation by SARS-CoV-2; DNA damage response (only ATM dependent)" "Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain; FOXO-mediated transcription of cell death genes" "9" "0" "0.990" "0.673" "0.986" "1.005" "0.708" "1.062" "1.013" "0.687" "1.003" "1149.9" "1138.4" "774.5" "1133.6" "1155.6" "814.1" "1221.0" "1164.5" "790.5" "1153.0" "" "" "" "" "" "" "" "" "" "" "1033.9" "921.1" "700.5" "1106.6" "953.6" "814.1" "914.2" "1028.6" "707.3" "411.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311027039317612116" "False" "High" "IsMasterProtein" "Q9Y3B8" "Oligoribonuclease, mitochondrial OS=Homo sapiens OX=9606 GN=REXO2 PE=1 SV=3" "0.000" "False" "35.505" "24" "5" "10" "5" "237" "26.8" "6.87" "40.31" "5" "DNA metabolism;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00929" "25996" "ENSG00000076043" "REXO2" "B2R532; hsa:25996; Q32Q18; Q53FT1; Q6FIC6; Q9UFY7; Q9Y3B8" "" "Mitochondrial RNA degradation" "1" "0" "0.943" "0.964" "0.973" "1.017" "0.949" "0.945" "0.969" "0.977" "0.776" "1362.2" "1285.2" "1313.2" "1325.4" "1384.9" "1292.6" "1287.8" "1320.5" "1330.6" "1057.7" "" "" "" "" "" "" "" "" "" "" "1224.8" "1039.9" "1187.8" "1293.8" "1142.8" "1292.6" "964.3" "1166.3" "1190.6" "377.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8200753479416328933" "False" "High" "IsMasterProtein" "Q8NF50" "Dedicator of cytokinesis protein 8 OS=Homo sapiens OX=9606 GN=DOCK8 PE=1 SV=3" "0.000" "False" "35.475" "6" "12" "14" "12" "2099" "238.4" "6.87" "44.22" "12" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf06920, Pf11878, Pf14429, Pf20421, Pf20422" "81704" "ENSG00000107099" "DOCK8" "A2A350; A2BDF2; A4FU78; B7ZLP0; E9PH09; hsa:81704; Q3MV16; Q5JPJ1; Q8NF50; Q8TEP1; Q8WUY2; Q9BYJ5; Q9H1Q2; Q9H1Q3; Q9H308; Q9H7P2" "" "Factors involved in megakaryocyte development and platelet production; CDC42 GTPase cycle; RHOJ GTPase cycle; RAC1 GTPase cycle" "4" "0" "0.972" "1.026" "0.951" "0.921" "0.910" "1.010" "0.845" "0.945" "4.769" "703.7" "684.2" "722.0" "669.5" "648.2" "640.5" "710.6" "594.3" "665.3" "3356.0" "" "" "" "" "" "" "" "" "" "" "632.7" "553.7" "653.1" "653.5" "534.9" "640.5" "532.1" "524.9" "595.3" "1198.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1394219767961209764" "False" "High" "IsMasterProtein" "Q5T5Y3" "Calmodulin-regulated spectrin-associated protein 1 OS=Homo sapiens OX=9606 GN=CAMSAP1 PE=1 SV=2" "0.000" "False" "35.454" "8" "12" "12" "12" "1602" "177.9" "6.73" "36.72" "12" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf08683, Pf11971, Pf17095" "157922" "ENSG00000130559" "CAMSAP1" "A1L4L2; B2REB2; B2REB3; hsa:157922; Q5T5Y3; Q70W33; Q8NCY0; Q96E80; Q96FM3; Q9UFJ5" "" "" "0" "0" "0.959" "0.960" "0.985" "0.982" "0.944" "0.999" "0.898" "0.932" "1.027" "786.3" "754.4" "754.5" "774.6" "771.9" "742.6" "785.3" "706.0" "732.8" "807.7" "" "" "" "" "" "" "" "" "" "" "707.0" "610.5" "682.5" "756.1" "637.0" "742.6" "588.0" "623.6" "655.7" "288.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4600920651766906085" "False" "High" "IsMasterProtein" "O14602" "Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4" "0.000" "False" "35.418" "41" "8" "19" "2" "144" "16.4" "5.24" "74.15" "8" "protein metabolism;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01176" "9086" "ENSG00000198692" "EIF1AY" "hsa:9086; O14602; Q9BS77" "Translation factors" "" "1" "5" "0.927" "0.990" "1.008" "0.912" "1.051" "0.909" "0.983" "0.975" "0.744" "2581.7" "2393.0" "2557.1" "2603.6" "2354.5" "2713.0" "2347.1" "2538.8" "2517.8" "1920.0" "" "" "" "" "" "" "" "" "" "" "2321.2" "1936.3" "2313.0" "2541.4" "1943.0" "2713.0" "1757.5" "2242.5" "2252.9" "685.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5461850800476976864" "False" "High" "IsMasterProtein" "Q9UBB5" "Methyl-CpG-binding domain protein 2 OS=Homo sapiens OX=9606 GN=MBD2 PE=1 SV=1" "0.000" "False" "35.397" "28" "9" "10" "8" "411" "43.2" "10.04" "38.37" "9" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "8932" "ENSG00000134046" "MBD2" "hsa:8932; O95242; Q9UBB5; Q9UIS8" "Effect of progerin on genes involved in progeria" "NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Opening" "3" "0" "0.957" "1.015" "0.898" "1.019" "1.026" "1.077" "0.925" "0.901" "1.230" "801.6" "767.1" "813.6" "719.9" "816.8" "822.7" "863.4" "741.8" "722.0" "986.3" "" "" "" "" "" "" "" "" "" "" "720.7" "620.7" "735.9" "702.7" "674.0" "822.7" "646.5" "655.2" "646.0" "352.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4746600301426645057" "False" "High" "IsMasterProtein" "Q9BW62" "Katanin p60 ATPase-containing subunit A-like 1 OS=Homo sapiens OX=9606 GN=KATNAL1 PE=1 SV=1" "0.000" "False" "35.341" "24" "12" "14" "10" "490" "55.4" "6.74" "36.66" "12" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "84056" "ENSG00000102781" "KATNAL1" "A8K5X4; hsa:84056; Q9BW62" "" "" "0" "2" "1.053" "1.043" "1.021" "1.144" "1.084" "1.223" "1.102" "1.117" "1.139" "695.9" "733.0" "726.0" "710.7" "795.7" "754.0" "851.3" "766.6" "777.2" "792.3" "" "" "" "" "" "" "" "" "" "" "625.6" "593.1" "656.7" "693.7" "656.6" "754.0" "637.4" "677.1" "695.4" "282.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479844659917987073" "False" "High" "IsMasterProtein" "Q9NQ48" "Leucine zipper transcription factor-like protein 1 OS=Homo sapiens OX=9606 GN=LZTFL1 PE=1 SV=1" "0.000" "False" "35.333" "27" "7" "9" "7" "299" "34.6" "5.36" "36.14" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15294" "54585" "ENSG00000163818" "LZTFL1" "B3KSI9; B4E0K7; hsa:54585; Q8TC61; Q9NQ48; Q9NQ56" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "5" "0" "1.013" "1.015" "0.984" "1.128" "0.964" "1.070" "1.008" "1.040" "0.922" "631.0" "639.4" "640.5" "620.7" "711.4" "608.1" "675.3" "636.1" "656.2" "581.9" "" "" "" "" "" "" "" "" "" "" "567.3" "517.3" "579.3" "605.8" "587.1" "608.1" "505.7" "561.8" "587.1" "207.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3022549876159517749" "False" "High" "IsMasterProtein" "Q9H8W4" "Pleckstrin homology domain-containing family F member 2 OS=Homo sapiens OX=9606 GN=PLEKHF2 PE=1 SV=1" "0.000" "False" "35.210" "43" "7" "12" "7" "249" "27.8" "8.21" "47.38" "7" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00169, Pf01363" "79666" "ENSG00000175895" "PLEKHF2" "hsa:79666; Q9H8W4" "" "" "0" "0" "0.976" "0.912" "1.058" "0.993" "0.909" "1.017" "0.992" "0.902" "1.515" "859.3" "838.9" "783.5" "908.9" "853.3" "781.2" "873.4" "852.7" "774.8" "1301.8" "" "" "" "" "" "" "" "" "" "" "772.6" "678.8" "708.7" "887.2" "704.2" "781.2" "654.0" "753.1" "693.3" "464.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5148486115263509013" "False" "High" "IsMasterProtein" "Q9C0B0" "RING finger protein unkempt homolog OS=Homo sapiens OX=9606 GN=UNK PE=1 SV=2" "0.000" "False" "35.161" "15" "10" "11" "10" "810" "88.0" "6.86" "42.25" "10" "developmental processes;other biological processes" "other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf18384" "85451" "ENSG00000132478" "UNK" "hsa:85451; Q9C0B0" "" "" "0" "0" "0.969" "1.027" "0.980" "1.062" "1.007" "1.035" "0.999" "1.075" "0.932" "705.4" "683.3" "724.8" "691.5" "749.2" "710.3" "730.0" "704.5" "758.3" "657.2" "" "" "" "" "" "" "" "" "" "" "634.2" "552.9" "655.6" "675.0" "618.3" "710.3" "546.6" "622.3" "678.5" "234.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5424828533558395863" "False" "High" "IsMasterProtein" "O95352" "Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens OX=9606 GN=ATG7 PE=1 SV=1" "0.000" "False" "35.134" "15" "10" "11" "10" "703" "77.9" "6.24" "40.05" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00899, Pf16420" "10533" "ENSG00000197548" "ATG7" "B4E170; E9PB95; hsa:10533; O95352; Q7L8L0; Q9BWP2; Q9UFH4" "Nanoparticle triggered autophagic cell death; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Clock-controlled autophagy in bone metabolism; Primary ovarian insufficiency; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Neutrophil degranulation; Antigen processing: Ubiquitination & Proteasome degradation; Signaling by BRAF and RAF1 fusions; Macroautophagy" "12" "0" "1.042" "0.993" "0.936" "1.044" "0.977" "1.015" "0.989" "0.970" "0.846" "893.8" "931.1" "887.3" "836.3" "933.5" "873.2" "907.2" "883.5" "866.8" "756.5" "" "" "" "" "" "" "" "" "" "" "803.6" "753.4" "802.6" "816.4" "770.3" "873.2" "679.3" "780.4" "775.6" "270.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753763641550930270" "False" "High" "IsMasterProtein" "Q96NB3" "Zinc finger protein 830 OS=Homo sapiens OX=9606 GN=ZNF830 PE=1 SV=2" "0.000" "False" "35.103" "28" "9" "11" "9" "372" "42.0" "5.31" "40.74" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "91603" "ENSG00000198783" "ZNF830" "hsa:91603; Q96F60; Q96GZ5; Q96NB3; Q9BU38" "17q12 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "6" "0" "0.944" "1.012" "0.916" "1.003" "1.024" "0.943" "1.048" "1.068" "0.798" "737.5" "696.3" "746.3" "675.8" "739.7" "755.1" "695.2" "772.8" "787.7" "588.4" "" "" "" "" "" "" "" "" "" "" "663.1" "563.5" "675.0" "659.6" "610.5" "755.1" "520.5" "682.6" "704.8" "210.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142056770574276442" "False" "High" "IsMasterProtein" "Q96T58" "Msx2-interacting protein OS=Homo sapiens OX=9606 GN=SPEN PE=1 SV=1" "0.000" "False" "35.101" "3" "11" "12" "11" "3664" "402.0" "7.64" "34.50" "11" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf07744, Pf20808, Pf20809, Pf20810" "23013" "ENSG00000065526" "SPEN" "hsa:23013; Q96T58; Q9H9A8; Q9NWH5; Q9UQ01; Q9Y556" "Notch signaling pathway" "RHOBTB1 GTPase cycle" "2" "0" "0.980" "1.081" "0.904" "1.037" "0.994" "0.979" "0.907" "0.948" "1.139" "777.0" "761.8" "839.7" "702.2" "805.5" "772.6" "760.8" "704.3" "736.3" "884.9" "" "" "" "" "" "" "" "" "" "" "698.6" "616.4" "759.6" "685.5" "664.7" "772.6" "569.6" "622.1" "658.8" "315.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9211506236520866705" "False" "High" "IsMasterProtein" "O76071" "Probable cytosolic iron-sulfur protein assembly protein CIAO1 OS=Homo sapiens OX=9606 GN=CIAO1 PE=1 SV=1" "0.000" "False" "35.096" "31" "7" "10" "7" "339" "37.8" "4.97" "40.19" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "9391" "ENSG00000144021" "CIAO1" "A0MNN9; hsa:9391; O76071; Q53FM5" "2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.000" "1.031" "0.987" "0.985" "1.023" "0.977" "0.990" "1.028" "0.830" "1109.8" "1109.8" "1144.1" "1095.9" "1093.1" "1134.8" "1084.6" "1099.0" "1141.3" "921.6" "" "" "" "" "" "" "" "" "" "" "997.8" "898.0" "1034.9" "1069.8" "902.1" "1134.8" "812.1" "970.7" "1021.2" "329.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5608231469546375684" "False" "High" "IsMasterProtein" "O00161" "Synaptosomal-associated protein 23 OS=Homo sapiens OX=9606 GN=SNAP23 PE=1 SV=1" "0.000" "False" "35.036" "33" "7" "12" "7" "211" "23.3" "5.01" "47.75" "7" "cell-cell signaling;cell organization and biogenesis;stress response;transport" "plasma membrane;other membranes;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00835" "8773" "ENSG00000092531" "SNAP23" "hsa:8773; O00161; O00162; Q13602; Q6IAE3" "Insulin signaling" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; ER-Phagosome pathway; Translocation of SLC2A4 (GLUT4) to the plasma membrane; RAC3 GTPase cycle; RHOB GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Neutrophil degranulation; trans-Golgi Network Vesicle Budding" "13" "0" "0.919" "0.982" "0.982" "0.946" "0.993" "0.998" "1.012" "1.020" "0.733" "1212.9" "1114.6" "1190.6" "1191.1" "1148.0" "1204.2" "1210.5" "1227.9" "1237.2" "888.9" "" "" "" "" "" "" "" "" "" "" "1090.5" "901.9" "1076.9" "1162.6" "947.3" "1204.2" "906.4" "1084.5" "1107.0" "317.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "846923677132301137" "False" "High" "IsMasterProtein" "Q9UBS8" "E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens OX=9606 GN=RNF14 PE=1 SV=1" "0.000" "False" "34.978" "25" "9" "11" "9" "474" "53.8" "4.75" "37.93" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01485, Pf05773" "9604" "ENSG00000013561" "RNF14" "A0AV26; A6NMR2; A8MTW5; B3KN72; B7ZLV2; D3DQE4; hsa:9604; O94793; Q6IBV0; Q9UBS8" "Androgen receptor signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.008" "1.012" "0.971" "1.032" "0.996" "1.104" "0.983" "1.010" "1.097" "906.7" "914.1" "917.6" "880.1" "936.0" "903.4" "1001.1" "891.3" "915.8" "995.1" "" "" "" "" "" "" "" "" "" "" "815.2" "739.7" "830.0" "859.1" "772.4" "903.4" "749.6" "787.3" "819.5" "355.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4528933939237155494" "False" "High" "IsMasterProtein" "P25490" "Transcriptional repressor protein YY1 OS=Homo sapiens OX=9606 GN=YY1 PE=1 SV=2" "0.000" "False" "34.967" "27" "10" "14" "10" "414" "44.7" "6.25" "49.68" "10" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "7528" "ENSG00000100811" "YY1" "hsa:7528; P25490; Q14935" "Sterol regulatory element-binding proteins (SREBP) signaling; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Pleural mesothelioma" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; UCH proteinases; DNA Damage Recognition in GG-NER; TFAP2 (AP-2) family regulates transcription of growth factors and their receptors" "8" "0" "0.929" "0.938" "0.938" "0.937" "0.905" "0.981" "0.973" "0.899" "1.275" "1735.8" "1612.5" "1627.5" "1628.1" "1625.8" "1570.4" "1703.4" "1688.4" "1560.5" "2212.4" "" "" "" "" "" "" "" "" "" "" "1560.6" "1304.8" "1472.2" "1589.3" "1341.6" "1570.4" "1275.5" "1491.3" "1396.3" "789.8" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2273417600798469774" "False" "High" "IsMasterProtein" "Q10570" "Cleavage and polyadenylation specificity factor subunit 1 OS=Homo sapiens OX=9606 GN=CPSF1 PE=1 SV=2" "0.000" "False" "34.876" "8" "9" "12" "9" "1443" "160.8" "6.40" "44.85" "9" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03178, Pf10433" "29894" "ENSG00000071894; ENSG00000285049" "CPSF1" "hsa:29894; Q10570; Q96AF0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "7" "0" "1.074" "1.020" "0.995" "0.999" "0.980" "0.986" "0.924" "1.011" "1.161" "669.0" "718.8" "682.5" "665.4" "668.1" "655.6" "659.7" "618.0" "676.7" "776.5" "" "" "" "" "" "" "" "" "" "" "601.5" "581.6" "617.3" "649.5" "551.3" "655.6" "494.0" "545.9" "605.5" "277.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6079513439335487390" "False" "High" "IsMasterProtein" "Q9UGV2" "Protein NDRG3 OS=Homo sapiens OX=9606 GN=NDRG3 PE=1 SV=2" "0.000" "False" "34.855" "25" "6" "12" "6" "375" "41.4" "5.31" "53.47" "6" "signal transduction;other biological processes" "other cell component" "" "Pf03096" "57446" "ENSG00000101079" "NDRG3" "A2A2S8; E1P5U7; E1P5U8; hsa:57446; Q5TH32; Q96PL8; Q96SM2; Q9BXY7; Q9H3N7; Q9H411; Q9H8J6; Q9UGV2" "" "" "0" "0" "1.031" "1.085" "0.975" "1.103" "1.058" "0.952" "1.041" "1.164" "0.931" "1431.3" "1475.6" "1553.4" "1395.8" "1578.4" "1514.6" "1363.2" "1490.0" "1666.1" "1332.3" "" "" "" "" "" "" "" "" "" "" "1286.9" "1194.0" "1405.1" "1362.5" "1302.5" "1514.6" "1020.7" "1316.0" "1490.8" "475.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711793945183504944" "False" "High" "IsMasterProtein" "P23434" "Glycine cleavage system H protein, mitochondrial OS=Homo sapiens OX=9606 GN=GCSH PE=1 SV=2" "0.000" "False" "34.853" "23" "3" "20" "3" "173" "18.9" "4.88" "91.26" "3" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01597" "2653" "ENSG00000140905; ENSG00000291958" "GCSH" "hsa:2653; P23434; Q9H1E9" "" "Glycine degradation" "2" "0" "0.896" "0.918" "0.974" "0.970" "0.957" "0.937" "1.010" "0.935" "0.788" "1876.2" "1680.4" "1721.8" "1826.7" "1819.7" "1795.4" "1758.5" "1894.7" "1753.9" "1478.4" "" "" "" "" "" "" "" "" "" "" "1686.9" "1359.7" "1557.4" "1783.1" "1501.7" "1795.4" "1316.7" "1673.5" "1569.4" "527.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2305631654265975414" "False" "High" "IsMasterProtein" "Q96E11" "Ribosome-recycling factor, mitochondrial OS=Homo sapiens OX=9606 GN=MRRF PE=1 SV=1" "0.000" "False" "34.840" "26" "6" "11" "6" "262" "29.3" "9.79" "38.91" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity" "Pf01765" "92399" "ENSG00000148187" "MRRF" "A8K6D8; A8K6Z4; B7Z4X5; B7Z6P7; hsa:92399; Q5RKT1; Q5T7T0; Q5T7T1; Q5T7T2; Q5T7T3; Q5T7T4; Q5T7T5; Q96E11" "" "Mitochondrial translation termination" "1" "0" "0.970" "0.945" "0.955" "1.014" "1.020" "0.999" "1.067" "0.963" "1.007" "587.8" "569.9" "555.6" "561.5" "596.0" "599.7" "587.5" "627.4" "566.3" "591.7" "" "" "" "" "" "" "" "" "" "" "528.5" "461.2" "502.6" "548.1" "491.8" "599.7" "439.9" "554.2" "506.8" "211.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4398789072412591486" "False" "High" "IsMasterProtein" "Q14249" "Endonuclease G, mitochondrial OS=Homo sapiens OX=9606 GN=ENDOG PE=1 SV=4" "0.000" "False" "34.821" "30" "7" "11" "7" "297" "32.6" "9.50" "37.82" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01223" "2021" "ENSG00000167136" "ENDOG" "hsa:2021; Q14249; Q5T281; Q9BSP2" "Nanomaterial induced apoptosis; Acute viral myocarditis" "" "2" "0" "1.005" "1.059" "1.051" "1.069" "1.072" "1.092" "0.953" "1.067" "0.898" "598.0" "601.1" "633.0" "628.3" "639.5" "640.9" "653.0" "569.8" "638.0" "537.1" "" "" "" "" "" "" "" "" "" "" "537.7" "486.4" "572.6" "613.4" "527.7" "640.9" "489.0" "503.3" "570.9" "191.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622690060897357887" "False" "High" "IsMasterProtein" "Q9UII2" "ATPase inhibitor, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5IF1 PE=1 SV=1" "0.000" "False" "34.785" "43" "7" "29" "7" "106" "12.2" "9.35" "79.12" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf04568" "93974" "ENSG00000130770; ENSG00000285390" "ATP5IF1" "hsa:93974; Q5JXL8; Q6IAQ7; Q9BSL9; Q9UII2" "Electron transport chain: OXPHOS system in mitochondria" "" "1" "0" "0.980" "0.896" "0.897" "0.841" "0.934" "0.818" "0.918" "0.824" "0.817" "2244.7" "2200.1" "2011.2" "2013.1" "1887.6" "2096.4" "1836.4" "2059.8" "1848.7" "1832.9" "" "" "" "" "" "" "" "" "" "" "2018.2" "1780.2" "1819.2" "1965.1" "1557.7" "2096.4" "1375.0" "1819.3" "1654.2" "654.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "584714024089658403" "False" "High" "IsMasterProtein" "Q5XPI4" "E3 ubiquitin-protein ligase RNF123 OS=Homo sapiens OX=9606 GN=RNF123 PE=1 SV=1" "0.000" "False" "34.784" "9" "13" "15" "12" "1314" "148.4" "6.74" "42.31" "13" "protein metabolism;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf13920" "63891" "ENSG00000164068" "RNF123" "A1L4Q3; A6NLS5; hsa:63891; Q5I022; Q5XPI4; Q6PFW4; Q71RH0; Q8IW18; Q9H0M8; Q9H5L8; Q9H9T2" "" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases" "2" "0" "1.051" "0.983" "0.977" "1.020" "0.960" "1.031" "0.970" "0.992" "0.912" "1598.4" "1679.2" "1571.6" "1562.4" "1629.9" "1534.1" "1647.5" "1550.1" "1585.7" "1458.3" "" "" "" "" "" "" "" "" "" "" "1437.1" "1358.8" "1421.5" "1525.1" "1345.1" "1534.1" "1233.6" "1369.2" "1418.8" "520.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8682459872602538883" "False" "High" "IsMasterProtein" "Q8N108" "Mesoderm induction early response protein 1 OS=Homo sapiens OX=9606 GN=MIER1 PE=1 SV=2" "0.000" "False" "34.771" "22" "10" "10" "10" "512" "57.9" "4.42" "35.44" "10" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf19426" "57708" "ENSG00000198160" "MIER1" "C9JFD4; hsa:57708; Q08AE0; Q32NC4; Q5T104; Q5TAD1; Q5TAD2; Q5TAD4; Q5TAD5; Q6AHY8; Q86TB4; Q8N108; Q8N156; Q8N161; Q8NC37; Q8NES4; Q8NES5; Q8NES6; Q8WWG2; Q9HCG2" "" "" "0" "0" "0.980" "1.012" "1.003" "1.053" "0.985" "0.985" "1.035" "0.971" "1.011" "955.4" "935.9" "967.0" "958.5" "1005.9" "941.0" "941.3" "988.4" "927.7" "965.5" "" "" "" "" "" "" "" "" "" "" "859.0" "757.3" "874.7" "935.7" "830.1" "941.0" "704.9" "873.0" "830.1" "344.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3066040936717898467" "False" "High" "IsMasterProtein" "Q8NC60" "Nitric oxide-associated protein 1 OS=Homo sapiens OX=9606 GN=NOA1 PE=1 SV=2" "0.000" "False" "34.760" "15" "8" "11" "8" "698" "78.4" "8.66" "38.73" "8" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf01926, Pf21516" "84273" "ENSG00000084092" "NOA1" "hsa:84273; Q8N7L6; Q8NC60; Q9BSQ9" "" "" "0" "0" "0.964" "0.976" "0.900" "0.959" "0.890" "0.998" "0.986" "0.950" "0.965" "676.0" "652.0" "659.9" "608.7" "648.2" "601.5" "674.9" "666.7" "642.3" "652.6" "" "" "" "" "" "" "" "" "" "" "607.8" "527.6" "596.9" "594.2" "534.9" "601.5" "505.4" "588.9" "574.7" "232.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-852377223734167343" "False" "High" "IsMasterProtein" "Q4G176" "Malonate--CoA ligase ACSF3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF3 PE=1 SV=3" "0.000" "False" "34.748" "21" "12" "13" "11" "576" "64.1" "8.37" "37.27" "12" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00501, Pf13193" "197322" "ENSG00000176715" "ACSF3" "A8K4J8; C9JQL6; hsa:197322; Q4G176; Q6INA0; Q8N2F7" "" "Synthesis of very long-chain fatty acyl-CoAs" "1" "0" "1.105" "0.953" "0.986" "1.138" "1.071" "1.031" "1.089" "1.072" "1.953" "409.0" "452.2" "389.9" "403.2" "465.3" "438.2" "421.6" "445.5" "438.7" "798.9" "" "" "" "" "" "" "" "" "" "" "367.7" "365.9" "352.7" "393.6" "384.0" "438.2" "315.7" "393.5" "392.5" "285.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5383054079404854662" "False" "High" "IsMasterProtein" "P84022" "Mothers against decapentaplegic homolog 3 OS=Homo sapiens OX=9606 GN=SMAD3 PE=1 SV=1" "0.000" "False" "34.726" "23" "9" "12" "4" "425" "48.1" "7.15" "45.03" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03165, Pf03166" "4088" "ENSG00000166949" "SMAD3" "A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383; hsa:4088; O09064; O09144; O14510; O35273; P84022; Q92940; Q93002; Q9GKR4" "Androgen receptor signaling pathway; Cell cycle; AGE/RAGE pathway; Adipogenesis; Endoderm differentiation; Mesodermal commitment pathway; Extracellular vesicle-mediated signaling in recipient cells; Mesodermal commitment pathway; Ovarian infertility; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Canonical and non-canonical TGF-B signaling; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Neovascularization processes; Vitamin D in inflammatory diseases; Envelope proteins and their potential roles in EDMD physiopathology; Hippo signaling regulation pathways; Hepatitis B infection; TGF-beta receptor signaling in skeletal dysplasias; Overlap between signal transduction pathways contributing to LMNA laminopathies; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Progeria-associated lipodystrophy; GDNF signaling; Urotensin-II-mediated signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ub-specific processing proteases; Formation of axial mesoderm; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Signaling by NODAL; FOXO-mediated transcription of cell cycle genes; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation; Formation of definitive endoderm; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; RUNX3 regulates BCL2L11 (BIM) transcription; Signaling by Activin; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; Interleukin-37 signaling; RUNX3 regulates CDKN1A transcription; NOTCH4 Intracellular Domain Regulates Transcription; SMAD4 MH2 Domain Mutants in Cancer; SMAD2/3 MH2 Domain Mutants in Cancer" "56" "0" "1.054" "0.971" "1.074" "1.040" "0.963" "1.047" "1.081" "1.046" "1.226" "133.0" "140.2" "129.0" "142.8" "138.3" "128.0" "139.2" "143.7" "139.1" "162.9" "" "" "" "" "" "" "" "" "" "" "119.5" "113.4" "116.7" "139.4" "114.1" "128.0" "104.2" "126.9" "124.4" "58.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-989694424414112882" "False" "High" "IsMasterProtein" "Q6P2P2" "Protein arginine N-methyltransferase 9 OS=Homo sapiens OX=9606 GN=PRMT9 PE=1 SV=1" "0.000" "False" "34.725" "15" "12" "13" "12" "845" "94.4" "5.25" "38.74" "12" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf06325" "90826" "ENSG00000164169" "PRMT9" "A8KA39; B3KU92; hsa:90826; Q6P2P2; Q6ZR58; Q8N383; Q9BT55; Q9NT98" "" "" "0" "0" "1.058" "1.109" "1.012" "1.066" "1.065" "1.039" "1.024" "1.051" "1.018" "1178.2" "1246.3" "1307.2" "1192.0" "1255.4" "1254.5" "1224.4" "1206.1" "1238.3" "1199.9" "" "" "" "" "" "" "" "" "" "" "1059.3" "1008.5" "1182.4" "1163.6" "1036.0" "1254.5" "916.8" "1065.3" "1108.0" "428.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022881073250375863" "False" "High" "IsMasterProtein" "P16455" "Methylated-DNA--protein-cysteine methyltransferase OS=Homo sapiens OX=9606 GN=MGMT PE=1 SV=1" "0.000" "False" "34.656" "33" "5" "11" "5" "207" "21.6" "8.10" "50.06" "5" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01035, Pf02870" "4255" "ENSG00000170430" "MGMT" "P16455; Q5VY78" "Direct reversal repair; DNA repair pathways, full network; p53 transcriptional gene network" "MGMT-mediated DNA damage reversal" "4" "0" "0.967" "0.958" "0.982" "0.987" "0.942" "0.982" "0.972" "0.909" "0.759" "1248.6" "1207.2" "1195.7" "1225.9" "1232.7" "1176.2" "1226.6" "1213.2" "1134.7" "947.3" "" "" "" "" "" "" "" "" "" "" "1122.6" "976.8" "1081.6" "1196.7" "1017.3" "1176.2" "918.4" "1071.5" "1015.3" "338.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4707319533501773453" "False" "High" "IsMasterProtein" "O95260" "Arginyl-tRNA--protein transferase 1 OS=Homo sapiens OX=9606 GN=ATE1 PE=1 SV=2" "0.000" "False" "34.636" "25" "10" "12" "10" "518" "59.1" "7.93" "43.23" "10" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04376, Pf04377" "11101" "ENSG00000107669" "ATE1" "hsa:11101; O95260; O95261; Q5SQQ3; Q8WW04" "" "" "0" "0" "1.000" "0.989" "1.015" "1.030" "0.968" "0.994" "0.987" "0.969" "0.875" "1100.6" "1100.9" "1088.0" "1116.5" "1133.6" "1065.9" "1093.9" "1085.9" "1065.9" "962.9" "" "" "" "" "" "" "" "" "" "" "989.5" "890.8" "984.1" "1089.9" "935.5" "1065.9" "819.1" "959.2" "953.8" "343.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5625477449042213507" "False" "High" "IsMasterProtein" "P04179" "Superoxide dismutase [Mn], mitochondrial OS=Homo sapiens OX=9606 GN=SOD2 PE=1 SV=3" "0.000" "False" "34.594" "30" "6" "11" "6" "222" "24.7" "8.25" "47.43" "6" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00081, Pf02777" "6648" "ENSG00000291237" "SOD2" "B2R7R1; B3KUK2; B4DL20; B4E3K9; E1P5A9; P04179; P78434; Q16792; Q5TCM1; Q96EE6; Q9P2Z3" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; VEGFA-VEGFR2 signaling; Oxidative stress response" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; Detoxification of Reactive Oxygen Species; Transcriptional activation of mitochondrial biogenesis; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "10" "0" "0.986" "1.031" "1.038" "0.973" "0.956" "0.957" "0.977" "1.031" "0.767" "1073.7" "1058.2" "1106.7" "1114.0" "1044.7" "1026.5" "1027.2" "1048.9" "1107.2" "823.9" "" "" "" "" "" "" "" "" "" "" "965.4" "856.3" "1001.0" "1087.5" "862.1" "1026.5" "769.1" "926.4" "990.7" "294.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "652466818170242457" "False" "High" "IsMasterProtein" "Q9H993" "Damage-control phosphatase ARMT1 OS=Homo sapiens OX=9606 GN=ARMT1 PE=1 SV=1" "0.000" "False" "34.574" "23" "7" "10" "7" "441" "51.1" "5.76" "46.23" "7" "other metabolic processes;stress response" "" "other molecular function" "Pf01937" "79624" "ENSG00000146476" "ARMT1" "hsa:79624; Q96FC6; Q9H993; Q9UFY5" "" "" "0" "0" "0.873" "0.939" "0.896" "0.858" "0.779" "0.940" "0.770" "0.784" "2.128" "837.7" "731.2" "786.3" "750.8" "718.4" "652.5" "787.6" "645.0" "656.5" "1782.2" "" "" "" "" "" "" "" "" "" "" "753.1" "591.7" "711.2" "732.9" "592.8" "652.5" "589.7" "569.7" "587.5" "636.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548420804533655280" "False" "High" "IsMasterProtein" "O43353" "Receptor-interacting serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=RIPK2 PE=1 SV=2" "0.000" "False" "34.540" "20" "9" "10" "9" "540" "61.2" "7.09" "42.23" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00619, Pf07714" "8767" "ENSG00000104312" "RIPK2" "B7Z748; hsa:8767; O43353; Q6UWF0" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Fas ligand pathway and stress induction of heat shock proteins; T-cell receptor signaling pathway" "Downstream TCR signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; p75NTR recruits signalling complexes; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases" "13" "0" "1.034" "1.090" "0.969" "1.049" "1.065" "1.008" "1.052" "1.065" "0.995" "945.9" "978.0" "1030.6" "917.0" "992.2" "1007.3" "953.9" "994.9" "1007.2" "940.7" "" "" "" "" "" "" "" "" "" "" "850.5" "791.4" "932.2" "895.1" "818.8" "1007.3" "714.2" "878.8" "901.2" "335.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8706245126759521959" "False" "High" "IsMasterProtein" "Q9BRP4" "Proteasomal ATPase-associated factor 1 OS=Homo sapiens OX=9606 GN=PAAF1 PE=1 SV=2" "0.000" "False" "34.513" "19" "7" "10" "7" "392" "42.2" "6.32" "38.19" "7" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80227" "ENSG00000175575" "PAAF1" "A6NDR5; B4DPB0; B7ZAS9; hsa:80227; Q4G165; Q53HS9; Q7Z500; Q8TBU6; Q9BRP4; Q9HAB6" "" "" "0" "0" "0.990" "0.998" "0.998" "1.054" "0.916" "1.005" "0.932" "1.030" "0.891" "619.7" "613.8" "618.5" "618.2" "652.9" "567.5" "622.5" "577.4" "638.5" "552.3" "" "" "" "" "" "" "" "" "" "" "557.1" "496.6" "559.5" "603.5" "538.8" "567.5" "466.1" "510.0" "571.3" "197.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8059414642460420196" "False" "High" "IsMasterProtein" "P13637" "Sodium/potassium-transporting ATPase subunit alpha-3 OS=Homo sapiens OX=9606 GN=ATP1A3 PE=1 SV=3" "0.000" "False" "34.506" "9" "7" "9" "2" "1013" "111.7" "5.38" "35.31" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "478" "ENSG00000105409" "ATP1A3" "B7Z2T0; B7Z401; F5H6J6; hsa:478; P13637; Q16732; Q16735; Q969K5" "Sudden infant death syndrome (SIDS) susceptibility pathways" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases" "4" "0" "0.964" "1.160" "0.982" "0.941" "0.944" "1.069" "0.953" "0.989" "0.789" "176.3" "170.0" "204.5" "173.2" "166.0" "166.4" "188.5" "168.1" "174.5" "139.1" "" "" "" "" "" "" "" "" "" "" "158.5" "137.6" "185.0" "169.1" "137.0" "166.4" "141.2" "148.5" "156.1" "49.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9117117300834082613" "False" "High" "IsMasterProtein" "Q9H5N1" "Rab GTPase-binding effector protein 2 OS=Homo sapiens OX=9606 GN=RABEP2 PE=1 SV=2" "0.000" "False" "34.497" "17" "11" "12" "11" "569" "63.5" "4.78" "39.12" "11" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf03528, Pf09311" "79874" "ENSG00000177548" "RABEP2" "hsa:79874; Q9H5N1" "Ciliary landscape; 16p11.2 distal deletion syndrome" "" "2" "0" "1.040" "1.073" "0.968" "1.055" "0.946" "1.047" "0.930" "0.999" "1.999" "365.2" "379.9" "391.7" "353.6" "385.3" "345.4" "382.2" "339.5" "364.7" "729.9" "" "" "" "" "" "" "" "" "" "" "328.4" "307.4" "354.3" "345.2" "317.9" "345.4" "286.2" "299.9" "326.4" "260.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5223570774126061662" "False" "High" "IsMasterProtein" "Q9UKA4" "A-kinase anchor protein 11 OS=Homo sapiens OX=9606 GN=AKAP11 PE=1 SV=1" "0.000" "False" "34.481" "7" "11" "13" "11" "1901" "210.4" "5.39" "41.63" "11" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "11215" "ENSG00000023516" "AKAP11" "hsa:11215; O75124; Q9NUK7; Q9UKA4" "G protein signaling pathways" "" "1" "0" "1.167" "0.918" "1.012" "1.177" "1.168" "1.092" "0.973" "1.096" "1.189" "657.9" "767.6" "603.7" "666.0" "774.7" "768.7" "718.7" "640.3" "720.9" "782.3" "" "" "" "" "" "" "" "" "" "" "591.5" "621.1" "546.1" "650.1" "639.3" "768.7" "538.1" "565.5" "645.1" "279.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3819481250379265452" "False" "High" "IsMasterProtein" "Q5JWF2" "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas OS=Homo sapiens OX=9606 GN=GNAS PE=1 SV=2" "0.000" "False" "34.430" "10" "9" "11" "8" "1037" "111.0" "5.03" "39.93" "9" "cell adhesion;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00503" "2778" "ENSG00000087460" "GNAS" "A2A2S3; E1P5G3; O75684; O75685; Q5JW67; Q5JWF1; Q5JWF2; Q9NY42" "Thyroid stimulating hormone (TSH) signaling pathway; Endothelin pathways; Corticotropin-releasing hormone signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; Thermogenesis; Hippo signaling regulation pathways; Purinergic signaling; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Prostaglandin and leukotriene metabolism in senescence ; Primary ovarian insufficiency; Prostaglandin and leukotriene metabolism in senescence ; Calcium regulation in cardiac cells; Estrogen signaling pathway; Serotonin receptor 4/6/7 and NR3C signaling" "G alpha (i) signalling events; G alpha (z) signalling events; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Prostacyclin signalling through prostacyclin receptor; Glucagon-type ligand receptors; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation in glucagon signalling; Hedgehog 'off' state" "29" "1" "0.936" "1.016" "1.055" "1.060" "0.973" "0.979" "0.956" "1.157" "0.810" "743.6" "696.2" "755.5" "784.2" "788.1" "723.6" "727.7" "710.7" "860.4" "602.6" "" "" "" "" "" "" "" "" "" "" "668.5" "563.4" "683.4" "765.5" "650.4" "723.6" "544.9" "627.8" "769.9" "215.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-437633753378296153" "False" "High" "IsMasterProtein" "Q9UKI8" "Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens OX=9606 GN=TLK1 PE=1 SV=2" "0.000" "False" "34.407" "13" "12" "14" "4" "766" "86.6" "8.72" "50.08" "12" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "nucleus" "kinase activity;other molecular function" "Pf00069" "9874" "ENSG00000198586" "TLK1" "B3KR15; B4DX87; hsa:9874; Q14150; Q8N591; Q9NYH2; Q9UKI8; Q9Y4F6" "miRNA regulation of DNA damage response; Pathways affected in adenoid cystic carcinoma; DNA damage response" "" "3" "0" "1.114" "1.045" "0.940" "1.144" "0.989" "1.065" "1.116" "1.015" "0.959" "320.2" "356.8" "334.7" "301.1" "366.4" "316.6" "341.0" "357.3" "324.9" "307.0" "" "" "" "" "" "" "" "" "" "" "287.9" "288.7" "302.7" "293.9" "302.3" "316.6" "255.4" "315.6" "290.8" "109.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5604147819280005923" "False" "High" "IsMasterProtein" "P50613" "Cyclin-dependent kinase 7 OS=Homo sapiens OX=9606 GN=CDK7 PE=1 SV=1" "0.000" "False" "34.401" "22" "7" "10" "7" "346" "39.0" "8.47" "42.51" "7" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1022" "ENSG00000134058; ENSG00000277273" "CDK7" "hsa:1022; P50613; Q9BS60; Q9UE19" "MicroRNAs in cardiomyocyte hypertrophy; Cell cycle; Cardiac hypertrophic response; Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "RNA polymerase II transcribes snRNA genes; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "43" "0" "1.014" "1.045" "1.017" "1.039" "0.988" "0.930" "0.999" "1.098" "1.019" "826.3" "837.7" "863.9" "840.4" "858.9" "816.4" "768.8" "825.2" "907.6" "842.0" "" "" "" "" "" "" "" "" "" "" "742.9" "677.8" "781.4" "820.4" "708.8" "816.4" "575.7" "728.9" "812.1" "300.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7482655995969634953" "False" "High" "IsMasterProtein" "Q9Y237" "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 OS=Homo sapiens OX=9606 GN=PIN4 PE=1 SV=1" "0.000" "False" "34.365" "45" "7" "20" "7" "131" "13.8" "9.77" "52.06" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13616" "5303" "ENSG00000102309" "PIN4" "A8E0G6; B3KXM0; F5H1P5; hsa:5303; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4; Q9Y237" "" "" "0" "0" "1.015" "0.939" "0.956" "0.973" "0.977" "0.960" "1.083" "0.939" "0.773" "2886.5" "2928.4" "2711.4" "2758.9" "2809.9" "2820.0" "2770.2" "3127.0" "2709.6" "2231.9" "" "" "" "" "" "" "" "" "" "" "2595.2" "2369.5" "2452.6" "2693.1" "2318.8" "2820.0" "2074.2" "2762.0" "2424.5" "796.7" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5234927014907967079" "False" "High" "IsMasterProtein" "Q9H0S4" "Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1" "0.000" "False" "34.332" "25" "9" "9" "9" "455" "50.6" "9.10" "34.57" "9" "RNA metabolism OR transcription;other metabolic processes;signal transduction" "nucleus" "other molecular function" "Pf00270, Pf00271" "51202" "ENSG00000213782" "DDX47" "B3KXP4; G5E955; hsa:51202; Q96GM0; Q96NV8; Q9H0S4; Q9UI98" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.994" "1.053" "0.916" "1.054" "1.352" "0.924" "0.895" "0.911" "0.707" "350.4" "348.5" "369.1" "321.0" "369.4" "473.6" "323.7" "313.7" "319.4" "247.8" "" "" "" "" "" "" "" "" "" "" "315.1" "282.0" "333.9" "313.4" "304.9" "473.6" "242.4" "277.1" "285.8" "88.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9168897576622990740" "False" "High" "IsMasterProtein" "O43617" "Trafficking protein particle complex subunit 3 OS=Homo sapiens OX=9606 GN=TRAPPC3 PE=1 SV=1" "0.000" "False" "34.324" "36" "8" "14" "8" "180" "20.3" "4.96" "49.28" "8" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "27095" "ENSG00000054116" "TRAPPC3" "A6NDN0; B2RDN2; D3DPS2; hsa:27095; O43617" "" "COPII-mediated vesicle transport; RAB GEFs exchange GTP for GDP on RABs" "2" "0" "0.996" "1.069" "0.980" "1.133" "1.007" "1.037" "1.072" "1.031" "0.915" "1063.6" "1058.9" "1137.1" "1042.8" "1205.1" "1071.5" "1102.7" "1140.3" "1096.9" "973.6" "" "" "" "" "" "" "" "" "" "" "956.3" "856.8" "1028.5" "1017.9" "994.5" "1071.5" "825.7" "1007.2" "981.5" "347.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "353320057128082956" "False" "High" "IsMasterProtein" "Q13242" "Serine/arginine-rich splicing factor 9 OS=Homo sapiens OX=9606 GN=SRSF9 PE=1 SV=1" "0.000" "False" "34.306" "34" "7" "16" "7" "221" "25.5" "8.65" "54.00" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "8683" "ENSG00000111786" "SRSF9" "hsa:8683; Q13242; Q52LD1" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.977" "0.941" "0.982" "0.966" "0.897" "0.936" "0.936" "0.973" "0.959" "622.3" "607.9" "585.4" "610.8" "601.1" "558.2" "582.2" "582.6" "605.3" "597.0" "" "" "" "" "" "" "" "" "" "" "559.5" "491.9" "529.6" "596.2" "496.0" "558.2" "435.9" "514.6" "541.6" "213.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5842118922115640430" "False" "High" "IsMasterProtein" "P36405" "ADP-ribosylation factor-like protein 3 OS=Homo sapiens OX=9606 GN=ARL3 PE=1 SV=2" "0.000" "False" "34.285" "40" "5" "11" "5" "182" "20.4" "7.24" "50.75" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "403" "ENSG00000138175" "ARL3" "B2R6C7; hsa:403; P36405; Q53X83; Q5JSM2" "Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "5" "0" "0.993" "1.004" "1.013" "1.089" "1.002" "1.024" "1.052" "1.071" "0.813" "1017.9" "1011.2" "1022.4" "1030.7" "1108.0" "1020.0" "1042.6" "1070.5" "1089.9" "827.8" "" "" "" "" "" "" "" "" "" "" "915.2" "818.2" "924.8" "1006.2" "914.4" "1020.0" "780.7" "945.6" "975.3" "295.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6575601821171362980" "False" "High" "IsMasterProtein" "P39019" "Small ribosomal subunit protein eS19 OS=Homo sapiens OX=9606 GN=RPS19 PE=1 SV=2" "0.000" "False" "34.282" "53" "8" "20" "8" "145" "16.1" "10.32" "74.34" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01090" "6223" "ENSG00000105372" "RPS19" "hsa:6223; P39019" "Complement system; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "0.980" "0.939" "0.930" "0.958" "1.005" "0.927" "0.930" "0.897" "1.015" "2327.4" "2280.6" "2184.5" "2164.3" "2229.3" "2338.9" "2156.3" "2165.3" "2087.5" "2362.4" "" "" "" "" "" "" "" "" "" "" "2092.5" "1845.4" "1976.0" "2112.7" "1839.6" "2338.9" "1614.6" "1912.5" "1867.9" "843.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8009088926221679389" "False" "High" "IsMasterProtein" "P40616" "ADP-ribosylation factor-like protein 1 OS=Homo sapiens OX=9606 GN=ARL1 PE=1 SV=1" "0.000" "False" "34.255" "31" "5" "11" "5" "181" "20.4" "5.72" "39.72" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00025" "400" "ENSG00000120805" "ARL1" "B4DWW1; hsa:400; P40616; P80417; Q53XB1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.994" "0.932" "0.982" "1.082" "0.958" "1.043" "0.969" "1.007" "0.822" "743.1" "738.7" "692.3" "729.6" "804.4" "711.8" "775.0" "720.2" "748.0" "610.5" "" "" "" "" "" "" "" "" "" "" "668.2" "597.8" "626.2" "712.2" "663.8" "711.8" "580.3" "636.2" "669.3" "217.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5167676998188788346" "False" "High" "IsMasterProtein" "Q96EV2" "RNA-binding protein 33 OS=Homo sapiens OX=9606 GN=RBM33 PE=1 SV=3" "0.000" "False" "34.239" "10" "9" "11" "9" "1170" "129.9" "6.93" "42.69" "9" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "155435" "ENSG00000184863" "RBM33" "A4D244; B5MC24; hsa:155435; Q52LF5; Q75LN9; Q75ML5; Q96EV2; Q9NSV0" "" "" "0" "0" "0.974" "0.986" "0.947" "1.027" "1.027" "1.063" "1.024" "0.961" "1.015" "754.2" "734.7" "743.6" "714.4" "775.0" "774.9" "801.6" "772.5" "724.9" "765.3" "" "" "" "" "" "" "" "" "" "" "678.1" "594.5" "672.6" "697.3" "639.5" "774.9" "600.2" "682.3" "648.7" "273.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6183242122487478565" "False" "High" "IsMasterProtein" "Q8TDP1" "Ribonuclease H2 subunit C OS=Homo sapiens OX=9606 GN=RNASEH2C PE=1 SV=1" "0.000" "False" "34.201" "70" "8" "11" "8" "164" "17.8" "5.03" "37.50" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "" "Pf08615" "84153" "ENSG00000172922" "RNASEH2C" "hsa:84153; Q8TDP1; Q9H7F5" "" "" "0" "0" "0.969" "0.957" "0.940" "0.996" "0.931" "0.961" "0.983" "0.916" "1.156" "938.8" "910.1" "898.6" "882.9" "935.5" "873.9" "901.8" "922.5" "859.8" "1084.9" "" "" "" "" "" "" "" "" "" "" "844.1" "736.4" "812.8" "861.9" "772.0" "873.9" "675.2" "814.8" "769.4" "387.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-474422990152712875" "False" "High" "IsMasterProtein" "P61923" "Coatomer subunit zeta-1 OS=Homo sapiens OX=9606 GN=COPZ1 PE=1 SV=1" "0.000" "False" "34.198" "34" "5" "9" "5" "177" "20.2" "4.81" "43.21" "5" "transport" "other membranes;cytosol;ER/Golgi" "" "Pf01217" "22818" "ENSG00000111481" "COPZ1" "B4DDX8; B4DHZ0; F8VS17; F8VWL5; hsa:22818; P61923; Q549N6; Q9Y3C3" "" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport" "2" "0" "0.960" "1.038" "1.025" "0.981" "0.970" "0.947" "0.997" "1.046" "0.866" "1298.1" "1246.8" "1347.5" "1331.2" "1273.3" "1259.3" "1229.7" "1294.2" "1358.0" "1124.1" "" "" "" "" "" "" "" "" "" "" "1167.2" "1008.9" "1218.9" "1299.4" "1050.7" "1259.3" "920.8" "1143.1" "1215.1" "401.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864018122010782004" "False" "High" "IsMasterProtein" "P35080" "Profilin-2 OS=Homo sapiens OX=9606 GN=PFN2 PE=1 SV=3" "0.000" "False" "34.191" "33" "4" "15" "4" "140" "15.0" "6.99" "45.12" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00235" "5217" "ENSG00000070087" "PFN2" "B2R4C8; D3DNI4; hsa:5217; P35080; Q4VBQ4; Q8WVF9; Q9HBK2" "Physico-chemical features and toxicity-associated pathways" "RHO GTPases Activate Formins; Signaling by ROBO receptors" "3" "0" "1.043" "0.973" "0.963" "0.978" "0.966" "1.046" "1.008" "0.958" "0.840" "798.3" "832.5" "776.6" "768.8" "781.1" "770.9" "835.2" "805.0" "764.7" "670.7" "" "" "" "" "" "" "" "" "" "" "717.7" "673.6" "702.5" "750.5" "644.6" "770.9" "625.4" "711.0" "684.3" "239.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5740436620154947735" "False" "High" "IsMasterProtein" "Q9BX68" "Adenosine 5'-monophosphoramidase HINT2 OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1" "0.000" "False" "34.171" "52" "6" "10" "6" "163" "17.2" "9.16" "49.55" "6" "other metabolic processes;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01230" "84681" "ENSG00000137133" "HINT2" "hsa:84681; Q5TCW3; Q9BX68" "" "RHOD GTPase cycle" "1" "0" "0.969" "0.947" "0.971" "1.047" "0.980" "1.003" "1.109" "0.987" "0.781" "1119.9" "1084.6" "1060.1" "1087.0" "1172.5" "1097.7" "1123.5" "1241.6" "1105.5" "874.8" "" "" "" "" "" "" "" "" "" "" "1006.9" "877.7" "958.9" "1061.1" "967.6" "1097.7" "841.3" "1096.6" "989.2" "312.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8144155955974209704" "False" "High" "IsMasterProtein" "P16220" "Cyclic AMP-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=CREB1 PE=1 SV=3" "0.000" "False" "34.117" "20" "5" "14" "3" "327" "35.1" "5.27" "56.56" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "1385" "ENSG00000118260" "CREB1" "hsa:1385; P16220; P21934; Q6V963; Q9UMA7" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Energy metabolism; miRNAs involved in DNA damage response; Folate-alcohol and cancer pathway hypotheses; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; MFAP5-mediated ovarian cancer cell motility and invasiveness; Ovarian infertility; MECP2 and associated Rett syndrome; Transcription factor regulation in adipogenesis; BDNF-TrkB signaling; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Mitochondrial gene expression; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Prion disease pathway; p38 MAPK signaling pathway; NO/cGMP/PKG mediated neuroprotection; White fat cell differentiation; PI3K-Akt signaling pathway; Phosphodiesterases in neuronal function; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; G1 to S cell cycle control; Fragile X syndrome; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; Hepatitis B infection; Melanoma; mBDNF and proBDNF regulation of GABA neurotransmission; CAMKK2 pathway; GPR143 in melanocytes and retinal pigment epithelium cells; Galanin receptor pathway; Neuroinflammation and glutamatergic signaling; Vasopressin-regulated water reabsorption; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Rubinstein-Taybi syndrome 1; Smith-Magenis and Potocki-Lupski syndrome copy number variation; Interferon type I signaling pathways; T-cell receptor signaling pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; DNA damage response; Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "FCGR3A-mediated IL10 synthesis; ADORA2B mediated anti-inflammatory cytokines production; HCMV Early Events; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; NGF-stimulated transcription; Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; MECP2 regulates transcription of neuronal ligands; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; NCAM signaling for neurite out-growth; Regulation of MECP2 expression and activity; Transcriptional regulation of granulopoiesis; CREB phosphorylation; Gastrin-CREB signalling pathway via PKC and MAPK; NOTCH2 intracellular domain regulates transcription; MECP2 regulates neuronal receptors and channels; CaMK IV-mediated phosphorylation of CREB; CREB1 phosphorylation through the activation of Adenylate Cyclase; CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde; PKA-mediated phosphorylation of CREB; CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling; MECP2 regulates transcription factors" "85" "2" "0.940" "0.986" "0.914" "0.972" "1.001" "0.920" "0.989" "0.934" "0.815" "900.9" "846.8" "888.4" "823.5" "876.0" "901.9" "828.9" "890.8" "841.5" "734.2" "" "" "" "" "" "" "" "" "" "" "810.0" "685.2" "803.6" "803.9" "722.9" "901.9" "620.7" "786.8" "753.0" "262.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4914593963434688361" "False" "High" "IsMasterProtein" "Q6P3X3" "Tetratricopeptide repeat protein 27 OS=Homo sapiens OX=9606 GN=TTC27 PE=1 SV=1" "0.000" "False" "34.090" "12" "10" "13" "10" "843" "96.6" "5.59" "45.61" "10" "" "" "" "Pf07719" "55622" "ENSG00000018699" "TTC27" "A6NKJ0; hsa:55622; Q6P3X3; Q96SS5; Q9BVF1; Q9NWR4; Q9NXG4" "" "" "0" "0" "1.017" "1.057" "0.977" "1.025" "1.037" "1.072" "0.950" "1.036" "2.936" "1089.6" "1108.3" "1151.8" "1064.4" "1116.7" "1129.7" "1167.7" "1034.6" "1128.8" "3198.9" "" "" "" "" "" "" "" "" "" "" "979.7" "896.8" "1041.8" "1039.0" "921.5" "1129.7" "874.4" "913.8" "1010.0" "1141.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5082096534662267594" "False" "High" "IsMasterProtein" "Q9C026" "E3 ubiquitin-protein ligase TRIM9 OS=Homo sapiens OX=9606 GN=TRIM9 PE=1 SV=1" "0.000" "False" "34.086" "17" "11" "13" "11" "710" "79.1" "6.84" "42.10" "11" "protein metabolism;other metabolic processes" "cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf00097, Pf00622, Pf00643" "114088" "ENSG00000100505" "TRIM9" "D3DSB7; D3DSB8; hsa:114088; Q92557; Q96D24; Q96NI4; Q9C025; Q9C026; Q9C027" "Orexin receptor pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.085" "1.001" "1.088" "1.016" "1.049" "1.096" "1.030" "1.048" "1.247" "804.6" "872.7" "805.3" "875.3" "817.6" "844.2" "882.2" "828.6" "843.5" "1003.5" "" "" "" "" "" "" "" "" "" "" "723.5" "706.2" "728.4" "854.4" "674.7" "844.2" "660.6" "731.9" "754.8" "358.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4828769571271312822" "False" "High" "IsMasterProtein" "P46108" "Adapter molecule crk OS=Homo sapiens OX=9606 GN=CRK PE=1 SV=2" "0.000" "False" "34.081" "35" "9" "12" "9" "304" "33.8" "5.55" "48.46" "9" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00017, Pf00018, Pf07653" "1398" "ENSG00000167193" "CRK" "A8MWE8; B0LPE8; D3DTH6; hsa:1398; P46108; Q96GA9; Q96HJ0" "Integrin-mediated cell adhesion; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Rett syndrome; EGF/EGFR signaling pathway; Gastrin signaling pathway; Insulin signaling; Regulation of actin cytoskeleton; GDNF signaling; Interferon type I signaling pathways; ErbB signaling pathway; T-cell receptor signaling pathway" "FCGR3A-mediated phagocytosis; Regulation of signaling by CBL; Regulation of actin dynamics for phagocytic cup formation; Downstream signal transduction; VEGFA-VEGFR2 Pathway; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; ARMS-mediated activation; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1; MET receptor recycling" "31" "0" "0.981" "0.988" "1.007" "1.029" "0.992" "0.946" "0.969" "1.033" "1.002" "1059.0" "1039.4" "1046.5" "1066.3" "1089.9" "1050.7" "1001.4" "1026.0" "1094.3" "1061.1" "" "" "" "" "" "" "" "" "" "" "952.1" "841.0" "946.6" "1040.9" "899.4" "1050.7" "749.8" "906.3" "979.1" "378.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2031700092780878303" "False" "High" "IsMasterProtein" "Q9Y5L4" "Mitochondrial import inner membrane translocase subunit Tim13 OS=Homo sapiens OX=9606 GN=TIMM13 PE=1 SV=1" "0.000" "False" "34.057" "45" "4" "16" "4" "95" "10.5" "8.18" "51.54" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf02953" "26517" "ENSG00000099800" "TIMM13" "hsa:26517; P62206; Q9UHL8; Q9WTL1; Q9Y5L4" "" "Mitochondrial protein import" "1" "0" "0.979" "0.963" "0.902" "0.988" "0.963" "0.987" "1.016" "0.960" "0.870" "1105.6" "1081.9" "1064.8" "997.6" "1092.7" "1064.7" "1091.5" "1123.3" "1061.6" "961.6" "" "" "" "" "" "" "" "" "" "" "994.0" "875.4" "963.1" "973.8" "901.7" "1064.7" "817.3" "992.2" "950.0" "343.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4833705581656825044" "False" "High" "IsMasterProtein" "Q96RT1" "Erbin OS=Homo sapiens OX=9606 GN=ERBIN PE=1 SV=2" "0.000" "False" "34.017" "9" "10" "12" "10" "1412" "158.2" "5.50" "39.18" "10" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity" "Pf00595, Pf13855" "55914" "ENSG00000112851" "ERBIN" "A0AVR1; B4E3F1; B7ZLV9; E7EQW9; E9PCR8; hsa:55914; Q1RMD0; Q86W38; Q96RT1; Q9NR18; Q9NW48; Q9ULJ5" "Nucleotide-binding oligomerization domain (NOD) pathway; Nod-like receptor (NLR) signaling pathway; Pathways affected in adenoid cystic carcinoma" "RHOG GTPase cycle; Downregulation of ERBB2 signaling; RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; Signaling by ERBB2 ECD mutants; Constitutive Signaling by Overexpressed ERBB2; Drug-mediated inhibition of ERBB2 signaling; Resistance of ERBB2 KD mutants to trastuzumab; Resistance of ERBB2 KD mutants to sapitinib; Resistance of ERBB2 KD mutants to tesevatinib; Resistance of ERBB2 KD mutants to neratinib; Resistance of ERBB2 KD mutants to osimertinib; Resistance of ERBB2 KD mutants to afatinib; Resistance of ERBB2 KD mutants to AEE788; Resistance of ERBB2 KD mutants to lapatinib; Drug resistance in ERBB2 TMD/JMD mutants" "26" "0" "1.003" "0.900" "0.947" "1.003" "0.939" "1.051" "0.955" "0.903" "0.794" "839.7" "842.6" "755.9" "795.1" "842.4" "788.4" "882.6" "801.7" "758.6" "666.4" "" "" "" "" "" "" "" "" "" "" "755.0" "681.8" "683.8" "776.1" "695.1" "788.4" "660.8" "708.1" "678.8" "237.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3087577180827751856" "False" "High" "IsMasterProtein" "Q15172" "Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform OS=Homo sapiens OX=9606 GN=PPP2R5A PE=1 SV=1" "0.000" "False" "34.000" "17" "7" "9" "6" "486" "56.2" "6.71" "38.39" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01603" "5525" "ENSG00000066027" "PPP2R5A" "B2R6D2; B7Z7L2; D3DT99; hsa:5525; Q15172; Q2NL72; Q5VVB2; Q8TBI9" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Glycogen synthesis and degradation; Cohesin complex - Cornelia de Lange syndrome" "PKR-mediated signaling; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Disassembly of the destruction complex and recruitment of AXIN to the membrane; RAF activation; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Negative regulation of MAPK pathway; Platelet sensitization by LDL; CTLA4 inhibitory signaling" "27" "0" "0.948" "0.910" "0.946" "0.914" "0.819" "0.947" "0.899" "0.870" "1.231" "780.7" "739.8" "710.3" "738.2" "713.3" "639.6" "739.7" "701.6" "679.3" "961.0" "" "" "" "" "" "" "" "" "" "" "701.9" "598.6" "642.5" "720.6" "588.6" "639.6" "553.8" "619.7" "607.8" "343.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4995035234308884546" "False" "High" "IsMasterProtein" "Q9Y6B6" "Small COPII coat GTPase SAR1B OS=Homo sapiens OX=9606 GN=SAR1B PE=1 SV=1" "0.000" "False" "33.959" "28" "6" "19" "2" "198" "22.4" "6.11" "62.86" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00025" "51128" "ENSG00000152700" "SAR1B" "D3DQA4; hsa:51128; Q567T4; Q9Y6B6" "Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism; Enterocyte cholesterol metabolism" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Chylomicron assembly" "10" "4" "1.098" "1.069" "1.133" "1.043" "1.046" "1.023" "1.068" "1.105" "0.813" "1387.8" "1523.8" "1483.3" "1572.2" "1446.9" "1451.5" "1419.2" "1482.1" "1533.9" "1128.9" "" "" "" "" "" "" "" "" "" "" "1247.8" "1233.0" "1341.7" "1534.7" "1194.0" "1451.5" "1062.7" "1309.1" "1372.5" "403.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4941414792679987409" "False" "High" "IsMasterProtein" "Q00403" "Transcription initiation factor IIB OS=Homo sapiens OX=9606 GN=GTF2B PE=1 SV=1" "0.000" "False" "33.959" "35" "9" "10" "9" "316" "34.8" "8.35" "38.56" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00382, Pf08271" "2959" "ENSG00000137947" "GTF2B" "A8K1A7; hsa:2959; Q00403; Q5JS30" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "0.955" "0.932" "0.915" "0.957" "0.915" "1.031" "0.872" "0.870" "1.997" "558.3" "533.2" "520.4" "510.9" "534.1" "510.7" "575.7" "487.1" "485.7" "1114.6" "" "" "" "" "" "" "" "" "" "" "502.0" "431.5" "470.7" "498.7" "440.7" "510.7" "431.1" "430.2" "434.6" "397.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-145222249138625553" "False" "High" "IsMasterProtein" "Q9BYG3" "MKI67 FHA domain-interacting nucleolar phosphoprotein OS=Homo sapiens OX=9606 GN=NIFK PE=1 SV=1" "0.000" "False" "33.946" "37" "8" "10" "8" "293" "34.2" "9.88" "39.82" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf12196" "84365" "ENSG00000155438" "NIFK" "A8K788; hsa:84365; Q8TB66; Q96ED4; Q9BYG3" "" "" "0" "0" "1.026" "1.062" "0.955" "0.985" "1.070" "1.003" "0.921" "0.990" "0.996" "1008.0" "1033.8" "1070.7" "962.4" "993.3" "1078.3" "1010.9" "928.0" "997.6" "1003.9" "" "" "" "" "" "" "" "" "" "" "906.3" "836.5" "968.5" "939.5" "819.7" "1078.3" "756.9" "819.7" "892.7" "358.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4988344905656775202" "False" "High" "IsMasterProtein" "Q92665" "Small ribosomal subunit protein mS31 OS=Homo sapiens OX=9606 GN=MRPS31 PE=1 SV=3" "0.000" "False" "33.928" "27" "11" "15" "11" "395" "45.3" "9.29" "40.68" "11" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf15433" "10240" "ENSG00000102738" "MRPS31" "B2RCS3; hsa:10240; Q5VYC8; Q8WTV8; Q92665" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.971" "0.912" "0.963" "0.922" "0.893" "0.894" "0.961" "1.005" "1.535" "429.9" "417.3" "392.0" "414.1" "396.4" "383.8" "384.4" "413.1" "432.0" "660.0" "" "" "" "" "" "" "" "" "" "" "386.5" "337.6" "354.6" "404.2" "327.1" "383.8" "287.8" "364.8" "386.6" "235.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7666744292030772641" "False" "High" "IsMasterProtein" "Q9BRK5" "45 kDa calcium-binding protein OS=Homo sapiens OX=9606 GN=SDF4 PE=1 SV=1" "0.000" "False" "33.831" "25" "8" "12" "8" "362" "41.8" "4.86" "43.10" "8" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13202, Pf13499" "51150" "" "SDF4" "B1AME5; B1AME6; B2RDF1; B4DSM1; hsa:51150; Q53G52; Q53HQ9; Q8NBQ3; Q96AA1; Q9BRK5; Q9NZP7; Q9UN53" "" "" "0" "0" "0.926" "0.887" "0.937" "0.944" "0.892" "1.045" "0.982" "0.927" "1.149" "1411.2" "1306.1" "1252.4" "1321.6" "1332.7" "1258.5" "1474.4" "1386.2" "1307.9" "1622.1" "" "" "" "" "" "" "" "" "" "" "1268.8" "1056.8" "1132.8" "1290.1" "1099.7" "1258.5" "1104.0" "1224.4" "1170.3" "579.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8117558468974038429" "False" "High" "IsMasterProtein" "Q96Q11" "CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TRNT1 PE=1 SV=2" "0.000" "False" "33.823" "21" "10" "11" "10" "434" "50.1" "8.10" "38.02" "10" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf01743, Pf12627" "51095" "ENSG00000072756" "TRNT1" "A8K2Z6; B7WP13; C9JKA2; hsa:51095; Q8ND57; Q96Q11; Q9BS97; Q9Y362" "" "tRNA processing in the nucleus; tRNA processing in the mitochondrion" "2" "0" "0.942" "0.999" "0.999" "0.996" "0.976" "0.984" "1.009" "1.005" "1.025" "433.1" "407.8" "432.9" "432.7" "431.3" "422.8" "426.4" "437.2" "435.5" "443.8" "" "" "" "" "" "" "" "" "" "" "389.4" "330.0" "391.6" "422.3" "355.9" "422.8" "319.3" "386.1" "389.6" "158.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2296645769357171248" "False" "High" "IsMasterProtein" "Q4G0J3" "La-related protein 7 OS=Homo sapiens OX=9606 GN=LARP7 PE=1 SV=1" "0.000" "False" "33.821" "17" "9" "10" "9" "582" "66.9" "9.55" "36.63" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf05383, Pf08777" "51574" "ENSG00000174720" "LARP7" "B2ZHN6; hsa:51574; Q3B7A9; Q4G0J3; Q9P1S7; Q9Y3Z8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.068" "1.028" "0.994" "1.029" "1.072" "0.975" "0.929" "0.972" "1.124" "703.0" "751.0" "723.1" "698.6" "723.1" "753.9" "685.1" "653.0" "683.6" "789.9" "" "" "" "" "" "" "" "" "" "" "632.1" "607.7" "654.0" "681.9" "596.7" "753.9" "513.0" "576.8" "611.7" "282.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6354667477089484627" "False" "High" "IsMasterProtein" "Q5T2E6" "Armadillo-like helical domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ARMH3 PE=1 SV=1" "0.000" "False" "33.811" "15" "9" "10" "9" "689" "78.7" "6.60" "33.79" "9" "other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf08427" "79591" "ENSG00000120029" "ARMH3" "hsa:79591; Q2TB87; Q5T2E6; Q9H8Z9" "" "" "0" "0" "0.996" "1.005" "0.950" "0.996" "0.965" "0.976" "1.018" "1.006" "0.729" "1197.6" "1193.2" "1204.0" "1137.9" "1192.3" "1155.9" "1168.3" "1218.6" "1204.7" "873.1" "" "" "" "" "" "" "" "" "" "" "1076.8" "965.5" "1089.0" "1110.8" "983.9" "1155.9" "874.8" "1076.4" "1077.9" "311.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826261878749587371" "False" "High" "IsMasterProtein" "P39023" "Large ribosomal subunit protein uL3 OS=Homo sapiens OX=9606 GN=RPL3 PE=1 SV=2" "0.000" "False" "33.765" "26" "12" "15" "12" "403" "46.1" "10.18" "44.04" "12" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00297" "6122" "ENSG00000100316" "RPL3" "B2RDV9; hsa:6122; P39023; Q15548; Q5I0G0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.939" "1.003" "0.942" "0.920" "0.999" "0.866" "0.853" "1.029" "0.991" "727.3" "682.9" "729.8" "685.0" "669.3" "726.4" "629.7" "620.7" "748.1" "720.9" "" "" "" "" "" "" "" "" "" "" "653.9" "552.6" "660.1" "668.6" "552.3" "726.4" "471.5" "548.2" "669.4" "257.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2748783261369810529" "False" "High" "IsMasterProtein" "P11182" "Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DBT PE=1 SV=4" "0.000" "False" "33.740" "26" "10" "13" "10" "482" "53.5" "8.51" "53.46" "10" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.003" "1.033" "1.124" "1.008" "1.044" "1.024" "1.064" "1.037" "0.881" "1276.1" "1279.6" "1318.3" "1434.2" "1286.1" "1332.8" "1306.7" "1357.2" "1323.5" "1124.8" "" "" "" "" "" "" "" "" "" "" "1147.4" "1035.4" "1192.5" "1400.0" "1061.3" "1332.8" "978.5" "1198.8" "1184.3" "401.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822360151641721881" "False" "High" "IsMasterProtein" "Q9NP81" "Serine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=SARS2 PE=1 SV=1" "0.000" "False" "33.723" "25" "10" "10" "10" "518" "58.2" "8.13" "36.28" "10" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00587" "54938" "ENSG00000104835; ENSG00000283104" "SARS2" "A6NHW7; B4DE10; hsa:54938; Q9BVP3; Q9NP81" "Selenium metabolism and selenoproteins" "Mitochondrial tRNA aminoacylation" "2" "0" "1.056" "1.107" "0.995" "1.108" "1.039" "1.017" "1.059" "1.068" "1.217" "644.2" "680.2" "713.2" "641.0" "713.7" "669.6" "655.0" "682.1" "687.7" "783.8" "" "" "" "" "" "" "" "" "" "" "579.2" "550.4" "645.1" "625.7" "588.9" "669.6" "490.4" "602.4" "615.4" "279.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8831328934271129534" "False" "High" "IsMasterProtein" "Q92733" "Proline-rich protein PRCC OS=Homo sapiens OX=9606 GN=PRCC PE=1 SV=1" "0.000" "False" "33.712" "19" "8" "10" "8" "491" "52.4" "5.10" "45.04" "8" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf10253" "5546" "ENSG00000143294" "PRCC" "A8K1F7; hsa:5546; O00665; O00724; Q5SZ06; Q92733" "MET in type 1 papillary renal cell carcinoma; Type 2 papillary renal cell carcinoma; IL-18 signaling pathway" "mRNA Splicing - Major Pathway" "4" "0" "1.058" "0.958" "1.054" "1.035" "1.154" "0.991" "1.104" "0.947" "0.920" "879.9" "931.1" "843.1" "927.7" "910.4" "1015.7" "871.6" "971.1" "833.0" "809.2" "" "" "" "" "" "" "" "" "" "" "791.1" "753.4" "762.6" "905.6" "751.3" "1015.7" "652.6" "857.7" "745.4" "288.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7173448255119182363" "False" "High" "IsMasterProtein" "P27635" "Large ribosomal subunit protein uL16 OS=Homo sapiens OX=9606 GN=RPL10 PE=1 SV=5" "0.000" "False" "33.709" "40" "7" "11" "7" "214" "24.6" "10.08" "40.20" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00252" "6134" "ENSG00000147403" "RPL10" "A3KQT0; D3DWW6; hsa:6134; P27635; Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5" "Cytoplasmic ribosomal proteins; Primary ovarian insufficiency" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination" "15" "0" "0.978" "1.102" "1.051" "0.960" "1.176" "1.010" "0.951" "1.108" "0.940" "825.7" "807.6" "910.1" "867.5" "792.9" "970.9" "834.1" "785.2" "914.9" "776.3" "" "" "" "" "" "" "" "" "" "" "742.4" "653.5" "823.3" "846.8" "654.3" "970.9" "624.6" "693.6" "818.7" "277.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6883226900925947322" "False" "High" "IsMasterProtein" "Q9BW83" "Intraflagellar transport protein 27 homolog OS=Homo sapiens OX=9606 GN=IFT27 PE=1 SV=1" "0.000" "False" "33.696" "40" "6" "9" "6" "186" "20.5" "5.41" "37.63" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00071" "11020" "ENSG00000100360" "IFT27" "hsa:11020; O60897; Q9BW83" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); Ciliopathies; GDNF/RET signaling axis; Alstrom syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "8" "0" "0.996" "0.985" "1.000" "1.013" "1.005" "0.959" "1.017" "1.003" "0.785" "943.2" "939.4" "929.3" "942.8" "955.7" "947.9" "904.1" "959.7" "946.4" "740.1" "" "" "" "" "" "" "" "" "" "" "848.0" "760.1" "840.6" "920.3" "788.6" "947.9" "677.0" "847.6" "846.9" "264.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1239693809215146352" "False" "High" "IsMasterProtein" "P37275" "Zinc finger E-box-binding homeobox 1 OS=Homo sapiens OX=9606 GN=ZEB1 PE=1 SV=2" "0.000" "False" "33.695" "12" "10" "10" "10" "1124" "124.0" "4.94" "38.44" "10" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf05605" "6935" "ENSG00000148516" "ZEB1" "B4DJV0; B4DUW9; E9PCM7; F5H4I8; hsa:6935; P37275; Q12924; Q13800; Q2KJ05; Q5T968; Q5VZ84; Q8NB68" "Hypoxia-mediated EMT and stemness; TGF-beta signaling pathway; Clear cell renal cell carcinoma pathways; Epithelial to mesenchymal transition in colorectal cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; CCL18 signaling pathway; Hypertrophy model" "Interleukin-4 and Interleukin-13 signaling" "8" "0" "1.024" "0.962" "1.010" "1.062" "0.984" "1.059" "1.020" "0.978" "0.968" "595.8" "610.3" "573.1" "601.5" "633.0" "586.4" "631.2" "607.9" "582.6" "577.0" "" "" "" "" "" "" "" "" "" "" "535.7" "493.8" "518.4" "587.2" "522.4" "586.4" "472.6" "537.0" "521.3" "206.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7211345083341158849" "False" "High" "IsMasterProtein" "Q15382" "GTP-binding protein Rheb OS=Homo sapiens OX=9606 GN=RHEB PE=1 SV=1" "0.000" "False" "33.694" "41" "9" "13" "9" "184" "20.5" "5.92" "42.68" "9" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "6009" "ENSG00000106615" "RHEB" "B3KWN6; D3DX13; hsa:6009; Q15382; Q53Y56; Q99444" "Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Polycystic kidney disease pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway" "mTORC1-mediated signalling; Macroautophagy; Regulation of PTEN gene transcription; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK" "26" "0" "1.130" "1.022" "1.117" "1.082" "1.103" "1.026" "1.065" "1.151" "0.828" "1059.5" "1197.1" "1083.0" "1183.4" "1146.3" "1168.2" "1087.5" "1128.1" "1219.3" "877.2" "" "" "" "" "" "" "" "" "" "" "952.6" "968.7" "979.6" "1155.2" "946.0" "1168.2" "814.3" "996.4" "1091.0" "313.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5669236386910036788" "False" "High" "IsMasterProtein" "P46783" "Small ribosomal subunit protein eS10 OS=Homo sapiens OX=9606 GN=RPS10 PE=1 SV=1" "0.000" "False" "33.689" "47" "9" "24" "8" "165" "18.9" "10.15" "75.71" "9" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03501" "6204" "ENSG00000124614" "RPS10" "B2R4E3; hsa:6204; P46783; Q5TZC0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.996" "1.029" "0.919" "1.000" "1.076" "1.042" "0.912" "1.015" "1.295" "2334.3" "2325.7" "2401.3" "2144.6" "2334.8" "2511.0" "2431.9" "2128.7" "2370.4" "3023.3" "" "" "" "" "" "" "" "" "" "" "2098.8" "1881.9" "2172.1" "2093.4" "1926.7" "2511.0" "1820.9" "1880.2" "2121.0" "1079.2" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292844797767435028" "False" "High" "IsMasterProtein" "Q9H074" "Polyadenylate-binding protein-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAIP1 PE=1 SV=1" "0.000" "False" "33.678" "17" "9" "16" "9" "479" "53.5" "4.81" "49.97" "9" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf02854, Pf07145" "10605" "ENSG00000172239" "PAIP1" "A6NKV8; hsa:10605; O60455; Q96B61; Q9BS63; Q9H074" "Translation factors" "Deadenylation of mRNA; M-decay: degradation of maternal mRNAs by maternally stored factors; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "4" "0" "1.006" "1.010" "0.946" "1.072" "1.030" "1.064" "1.007" "0.981" "0.871" "913.9" "919.1" "923.2" "864.1" "979.9" "941.8" "972.7" "920.4" "896.2" "796.3" "" "" "" "" "" "" "" "" "" "" "821.7" "743.7" "835.1" "843.5" "808.7" "941.8" "728.3" "813.0" "801.9" "284.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "967030651674579734" "False" "High" "IsMasterProtein" "Q9NV88" "Integrator complex subunit 9 OS=Homo sapiens OX=9606 GN=INTS9 PE=1 SV=2" "0.000" "False" "33.670" "18" "10" "13" "10" "658" "73.8" "6.33" "43.86" "10" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10996, Pf16661, Pf21382" "55756" "ENSG00000104299" "INTS9" "B7Z560; B7Z6M5; hsa:55756; O00224; Q8TB16; Q9NV88" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.057" "1.102" "1.023" "1.079" "1.027" "0.971" "1.065" "1.042" "1.141" "670.3" "708.4" "738.5" "686.0" "723.6" "688.4" "650.9" "713.7" "698.7" "764.8" "" "" "" "" "" "" "" "" "" "" "602.7" "573.2" "668.0" "669.6" "597.1" "688.4" "487.4" "630.4" "625.2" "273.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6232139059952850141" "False" "High" "IsMasterProtein" "O94874" "E3 UFM1-protein ligase 1 OS=Homo sapiens OX=9606 GN=UFL1 PE=1 SV=2" "0.000" "False" "33.649" "15" "11" "15" "10" "794" "89.5" "6.79" "43.96" "11" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09743" "23376" "ENSG00000014123" "UFL1" "A0PJ53; B4DJ57; C0H5X5; hsa:23376; O94874; Q8N765; Q9NTQ0" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "1" "1.051" "0.975" "0.973" "1.031" "1.006" "1.056" "0.961" "0.994" "1.147" "593.7" "624.1" "579.1" "577.9" "612.3" "597.0" "626.8" "570.3" "589.9" "681.1" "" "" "" "" "" "" "" "" "" "" "533.8" "505.0" "523.8" "564.1" "505.3" "597.0" "469.3" "503.7" "527.8" "243.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6002739480164065296" "False" "High" "IsMasterProtein" "Q14137" "Ribosome biogenesis protein BOP1 OS=Homo sapiens OX=9606 GN=BOP1 PE=1 SV=2" "0.000" "False" "33.642" "15" "10" "12" "10" "746" "83.6" "6.19" "39.65" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf08145" "23246" "ENSG00000261236" "BOP1" "hsa:23246; Q14137; Q969Z6; Q96IS8; Q96Q25; Q9BSA7; Q9BVM0" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.024" "1.023" "0.953" "1.057" "1.043" "1.025" "0.995" "0.973" "1.673" "435.9" "446.1" "446.1" "415.6" "460.6" "454.7" "446.7" "433.5" "424.0" "729.1" "" "" "" "" "" "" "" "" "" "" "391.9" "361.0" "403.5" "405.7" "380.1" "454.7" "334.5" "382.9" "379.4" "260.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3107589471447250441" "False" "High" "IsMasterProtein" "Q9NV06" "DDB1- and CUL4-associated factor 13 OS=Homo sapiens OX=9606 GN=DCAF13 PE=1 SV=2" "0.000" "False" "33.616" "28" "13" "14" "13" "445" "51.4" "9.19" "43.39" "13" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04158, Pf08662" "25879" "ENSG00000164934" "DCAF13" "hsa:25879; Q3MII9; Q8NCH8; Q8TC51; Q96JY7; Q9NV06; Q9NZX3" "" "Neddylation; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.026" "0.624" "0.967" "1.020" "0.655" "0.995" "0.989" "0.634" "0.504" "1159.8" "1189.9" "723.9" "1122.1" "1183.1" "760.2" "1154.0" "1147.2" "735.5" "584.6" "" "" "" "" "" "" "" "" "" "" "1042.8" "962.8" "654.8" "1095.3" "976.3" "760.2" "864.1" "1013.3" "658.1" "208.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3468928122779261644" "False" "High" "IsMasterProtein" "P51398" "Small ribosomal subunit protein mS29 OS=Homo sapiens OX=9606 GN=DAP3 PE=1 SV=1" "0.000" "False" "33.616" "20" "7" "10" "7" "398" "45.5" "8.88" "43.79" "7" "protein metabolism;other metabolic processes;signal transduction" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10236" "7818" "ENSG00000132676" "DAP3" "B4DP59; B4DY62; E7EM60; hsa:7818; P51398; Q13044; Q68CT7; Q96Q20" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.924" "0.849" "0.924" "0.914" "0.866" "0.978" "0.925" "0.857" "1.221" "885.0" "817.4" "751.1" "817.6" "808.6" "766.3" "865.7" "818.2" "758.1" "1080.2" "" "" "" "" "" "" "" "" "" "" "795.7" "661.4" "679.4" "798.1" "667.3" "766.3" "648.2" "722.7" "678.3" "385.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5911471042018297925" "False" "High" "IsMasterProtein" "Q8ND56" "Protein LSM14 homolog A OS=Homo sapiens OX=9606 GN=LSM14A PE=1 SV=3" "0.000" "False" "33.611" "23" "9" "16" "9" "463" "50.5" "9.52" "49.57" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "26065" "ENSG00000257103; ENSG00000262860" "LSM14A" "B4DTG6; hsa:26065; Q76LX7; Q8ND56; Q96AR3; Q96K73; Q96SN5; Q9UFR3" "" "" "0" "0" "1.003" "0.980" "1.004" "1.080" "1.158" "1.103" "0.965" "0.943" "0.882" "1136.6" "1140.6" "1114.0" "1140.9" "1227.8" "1315.7" "1253.3" "1096.9" "1071.3" "1002.0" "" "" "" "" "" "" "" "" "" "" "1021.9" "922.9" "1007.6" "1113.7" "1013.2" "1315.7" "938.4" "968.8" "958.6" "357.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5593923735961542225" "False" "High" "IsMasterProtein" "Q9BRG1" "Vacuolar protein-sorting-associated protein 25 OS=Homo sapiens OX=9606 GN=VPS25 PE=1 SV=1" "0.000" "False" "33.599" "52" "9" "13" "9" "176" "20.7" "6.34" "48.32" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05871" "84313" "ENSG00000131475" "VPS25" "B2R581; hsa:84313; Q9BRG1" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "1.022" "0.987" "0.947" "1.031" "1.031" "1.014" "0.994" "1.034" "0.827" "642.1" "656.6" "633.7" "607.9" "661.8" "662.3" "651.1" "638.0" "664.1" "530.8" "" "" "" "" "" "" "" "" "" "" "577.3" "531.3" "573.2" "593.4" "546.1" "662.3" "487.6" "563.5" "594.2" "189.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3983981062552353097" "False" "High" "IsMasterProtein" "Q92600" "CCR4-NOT transcription complex subunit 9 OS=Homo sapiens OX=9606 GN=CNOT9 PE=1 SV=1" "0.000" "False" "33.586" "33" "8" "12" "8" "299" "33.6" "8.03" "43.05" "8" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04078" "9125" "ENSG00000144580" "CNOT9" "B2RPI0; B5MDQ4; B7Z1E5; hsa:9125; Q92600; Q96IX4" "" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.082" "1.031" "0.944" "1.042" "0.995" "1.047" "1.016" "0.994" "1.067" "1099.5" "1189.4" "1133.4" "1038.4" "1146.2" "1093.9" "1150.8" "1117.6" "1092.6" "1172.9" "" "" "" "" "" "" "" "" "" "" "988.6" "962.4" "1025.2" "1013.7" "945.9" "1093.9" "861.7" "987.1" "977.7" "418.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3785691322693480288" "False" "High" "IsMasterProtein" "O95834" "Echinoderm microtubule-associated protein-like 2 OS=Homo sapiens OX=9606 GN=EML2 PE=1 SV=1" "0.000" "False" "33.585" "16" "10" "10" "10" "649" "70.6" "6.32" "37.81" "10" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "24139" "ENSG00000125746" "EML2" "B7Z3I2; B7Z3Q9; hsa:24139; K7ERL7; O95834; Q59EN8; Q8N5A2; Q9UG50" "" "" "0" "0" "0.971" "1.018" "0.989" "1.039" "0.995" "1.012" "0.988" "1.012" "0.839" "1407.1" "1366.3" "1432.3" "1392.1" "1461.9" "1400.0" "1424.4" "1390.6" "1423.8" "1181.1" "" "" "" "" "" "" "" "" "" "" "1265.1" "1105.6" "1295.6" "1358.9" "1206.4" "1400.0" "1066.5" "1228.3" "1274.0" "421.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4854644692515831998" "False" "High" "IsMasterProtein" "Q86X76" "Deaminated glutathione amidase OS=Homo sapiens OX=9606 GN=NIT1 PE=1 SV=2" "0.000" "False" "33.550" "30" "9" "10" "9" "327" "35.9" "7.74" "39.56" "9" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00795" "4817" "ENSG00000158793" "NIT1" "B1AQP3; D3DVF4; hsa:4817; O76091; Q86X76" "" "" "0" "0" "1.065" "1.072" "1.033" "1.158" "1.030" "1.101" "1.072" "1.052" "0.937" "483.1" "514.5" "517.9" "499.0" "559.5" "497.5" "531.7" "517.9" "508.4" "452.6" "" "" "" "" "" "" "" "" "" "" "434.4" "416.3" "468.5" "487.0" "461.7" "497.5" "398.1" "457.5" "454.9" "161.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4147874032451066507" "False" "High" "IsMasterProtein" "Q15036" "Sorting nexin-17 OS=Homo sapiens OX=9606 GN=SNX17 PE=1 SV=1" "0.000" "False" "33.543" "17" "6" "10" "6" "470" "52.9" "7.46" "39.62" "6" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787, Pf18116, Pf21271, Pf21273" "9784" "ENSG00000115234" "SNX17" "B4DQM7; hsa:9784; Q15036; Q53HN7; Q6IAS3" "" "" "0" "0" "0.960" "1.055" "0.973" "1.117" "1.110" "1.044" "0.998" "1.123" "1.669" "300.7" "288.8" "317.2" "292.6" "335.9" "333.9" "314.0" "300.2" "337.6" "501.9" "" "" "" "" "" "" "" "" "" "" "270.4" "233.7" "286.9" "285.6" "277.2" "333.9" "235.1" "265.1" "302.1" "179.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2608297445267441955" "False" "High" "IsMasterProtein" "Q96QR8" "Transcriptional regulator protein Pur-beta OS=Homo sapiens OX=9606 GN=PURB PE=1 SV=3" "0.000" "False" "33.539" "23" "7" "10" "7" "312" "33.2" "5.43" "34.23" "7" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf04845" "5814" "ENSG00000146676" "PURB" "A4D2L7; hsa:5814; Q96QR8" "" "" "0" "0" "1.068" "1.093" "1.103" "1.104" "1.010" "1.009" "1.100" "1.069" "0.789" "517.4" "552.6" "565.3" "570.8" "571.1" "522.4" "521.8" "569.3" "553.0" "408.2" "" "" "" "" "" "" "" "" "" "" "465.2" "447.1" "511.3" "557.2" "471.3" "522.4" "390.7" "502.9" "494.8" "145.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5634495844004760" "False" "High" "IsMasterProtein" "O60907" "F-box-like/WD repeat-containing protein TBL1X OS=Homo sapiens OX=9606 GN=TBL1X PE=1 SV=3" "0.000" "False" "33.518" "18" "8" "12" "2" "577" "62.5" "6.55" "54.15" "8" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf08513" "6907" "ENSG00000101849" "TBL1X" "A8K044; A8K4J7; hsa:6907; O60907; Q86UY2" "Ectoderm differentiation; Ectoderm differentiation; Rett syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; RORA activates gene expression" "22" "0" "0.996" "1.161" "0.895" "1.005" "0.911" "0.940" "0.824" "1.072" "1.373" "123.7" "123.2" "143.6" "110.7" "124.4" "112.7" "116.3" "101.9" "132.7" "169.9" "" "" "" "" "" "" "" "" "" "" "111.3" "99.7" "129.9" "108.1" "102.6" "112.7" "87.1" "90.0" "118.7" "60.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8527831482180649662" "False" "High" "IsMasterProtein" "Q8NCE2" "Myotubularin-related protein 14 OS=Homo sapiens OX=9606 GN=MTMR14 PE=1 SV=2" "0.000" "False" "33.515" "17" "10" "11" "10" "650" "72.2" "6.24" "37.89" "10" "other metabolic processes" "cytosol;other cell component" "other molecular function" "" "64419" "ENSG00000163719" "MTMR14" "hsa:64419; Q0JTH5; Q0JU83; Q6PIZ4; Q6QE21; Q86VK9; Q8IYK1; Q8NCE2; Q8TCM7; Q9H6C0" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "1.017" "1.051" "0.973" "1.059" "0.973" "0.942" "1.018" "1.017" "0.908" "877.2" "892.0" "921.6" "853.7" "928.9" "853.9" "826.7" "893.2" "891.7" "796.9" "" "" "" "" "" "" "" "" "" "" "788.7" "721.8" "833.6" "833.3" "766.6" "853.9" "619.0" "788.9" "797.9" "284.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5643527966773386320" "False" "High" "IsMasterProtein" "Q8IWZ8" "SURP and G-patch domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SUGP1 PE=1 SV=2" "0.000" "False" "33.509" "20" "11" "14" "11" "645" "72.4" "7.61" "44.76" "11" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "57794" "ENSG00000105705" "SUGP1" "hsa:57794; O60378; Q6P3X9; Q8IWZ8; Q8TCQ4; Q8WWT4; Q8WWT5; Q9NTG3" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.984" "1.087" "0.972" "1.087" "1.159" "1.056" "1.061" "1.198" "1.259" "610.6" "600.7" "663.8" "593.7" "663.7" "707.5" "644.6" "647.6" "731.4" "768.6" "" "" "" "" "" "" "" "" "" "" "549.0" "486.1" "600.4" "579.6" "547.7" "707.5" "482.7" "572.0" "654.4" "274.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235464357787345308" "False" "High" "IsMasterProtein" "Q15370" "Elongin-B OS=Homo sapiens OX=9606 GN=ELOB PE=1 SV=1" "0.000" "False" "33.457" "52" "6" "18" "6" "118" "13.1" "4.88" "58.79" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00240" "6923" "ENSG00000103363" "ELOB" "B7WPD3; hsa:6923; Q15370" "Dual hijack model of Vif in HIV infection; Type 2 papillary renal cell carcinoma; Hijack of ubiquitination by SARS-CoV-2; Modulators of TCR signaling and T cell activation" "Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Neddylation; Inactivation of CSF3 (G-CSF) signaling; Evasion by RSV of host interferon responses; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "22" "0" "0.933" "0.974" "1.035" "1.009" "1.167" "0.988" "1.028" "1.049" "0.883" "1955.5" "1823.8" "1903.8" "2024.8" "1972.4" "2282.6" "1931.3" "2010.7" "2050.3" "1726.3" "" "" "" "" "" "" "" "" "" "" "1758.2" "1475.8" "1722.0" "1976.5" "1627.6" "2282.6" "1446.1" "1776.0" "1834.6" "616.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6077742637667714135" "False" "High" "IsMasterProtein" "Q00535" "Cyclin-dependent kinase 5 OS=Homo sapiens OX=9606 GN=CDK5 PE=1 SV=3" "0.000" "False" "33.437" "38" "10" "14" "9" "292" "33.3" "7.66" "49.46" "10" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1020" "ENSG00000164885" "CDK5" "A1XKG3; hsa:1020; Q00535" "miRNA regulation of DNA damage response; Nicotine effect on dopaminergic neurons; Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling in development and disease ; Alzheimer's disease; Neurogenesis regulation in the olfactory epithelium; DNA damage response" "NPAS4 regulates expression of target genes; NGF-stimulated transcription; Regulation of TP53 Activity through Phosphorylation; Factors involved in megakaryocyte development and platelet production; CRMPs in Sema3A signaling; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; DARPP-32 events; Activated NTRK2 signals through CDK5" "16" "0" "1.026" "1.003" "1.082" "1.067" "1.023" "1.043" "1.094" "1.033" "1.060" "982.8" "1008.0" "985.4" "1063.4" "1048.4" "1005.6" "1025.6" "1075.7" "1015.4" "1041.8" "" "" "" "" "" "" "" "" "" "" "883.7" "815.6" "891.4" "1038.0" "865.1" "1005.6" "767.9" "950.1" "908.5" "371.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "487381900913570393" "False" "High" "IsMasterProtein" "Q9H8Y8" "Golgi reassembly-stacking protein 2 OS=Homo sapiens OX=9606 GN=GORASP2 PE=1 SV=3" "0.000" "False" "33.425" "17" "6" "12" "6" "452" "47.1" "4.82" "49.49" "6" "cell organization and biogenesis;stress response;other biological processes" "other membranes;ER/Golgi" "" "Pf04495" "26003" "ENSG00000115806" "GORASP2" "B4DKT0; hsa:26003; Q53TE3; Q96I74; Q96K84; Q9H8Y8; Q9H946; Q9UFW4" "" "Golgi Cisternae Pericentriolar Stack Reorganization" "1" "0" "0.951" "0.917" "0.981" "0.997" "0.917" "1.040" "0.971" "0.949" "1.344" "1037.9" "987.1" "951.2" "1017.9" "1035.2" "951.9" "1079.0" "1007.3" "985.0" "1394.4" "" "" "" "" "" "" "" "" "" "" "933.1" "798.7" "860.4" "993.6" "854.3" "951.9" "807.9" "889.7" "881.4" "497.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568464795180105445" "False" "High" "IsMasterProtein" "Q9Y385" "Ubiquitin-conjugating enzyme E2 J1 OS=Homo sapiens OX=9606 GN=UBE2J1 PE=1 SV=2" "0.000" "False" "33.421" "23" "6" "11" "6" "318" "35.2" "6.74" "40.88" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf00179" "51465" "ENSG00000198833" "UBE2J1" "A8K3F9; hsa:51465; Q53F25; Q5W0N4; Q9BZ32; Q9NQL3; Q9NY66; Q9P011; Q9P0S0; Q9UF10; Q9Y385" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.998" "0.827" "1.000" "1.013" "0.792" "1.108" "0.894" "0.820" "0.909" "651.3" "649.7" "538.5" "651.3" "660.1" "515.6" "721.6" "582.2" "533.8" "592.1" "" "" "" "" "" "" "" "" "" "" "585.6" "525.7" "487.1" "635.7" "544.7" "515.6" "540.3" "514.3" "477.6" "211.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9158242191706838173" "False" "High" "IsMasterProtein" "Q71RC2" "La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3" "0.000" "False" "33.381" "16" "11" "11" "11" "724" "80.5" "6.61" "37.71" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf05383" "113251" "ENSG00000161813" "LARP4" "A8K6T1; E9PDG5; G3XAA8; G5E976; hsa:113251; Q5CZ97; Q6ZV14; Q71RC2; Q96NF9" "" "" "0" "0" "1.022" "1.107" "1.088" "0.969" "1.133" "1.061" "1.027" "1.034" "1.176" "1147.5" "1172.8" "1270.2" "1248.0" "1111.6" "1300.4" "1217.0" "1178.8" "1186.4" "1348.9" "" "" "" "" "" "" "" "" "" "" "1031.8" "949.0" "1148.9" "1218.2" "917.3" "1300.4" "911.2" "1041.2" "1061.6" "481.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5687850324260335343" "False" "High" "IsMasterProtein" "Q16875" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens OX=9606 GN=PFKFB3 PE=1 SV=1" "0.000" "False" "33.355" "19" "9" "11" "7" "520" "59.6" "8.21" "38.82" "9" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5209" "ENSG00000170525" "PFKFB3" "B7Z955; hsa:5209; O43622; O75902; Q16875; Q5VX15; Q5VX18; Q5VX19" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "1" "0.962" "0.999" "0.920" "1.015" "0.943" "0.978" "1.016" "0.921" "0.888" "322.1" "309.9" "321.6" "296.3" "326.9" "303.9" "315.0" "327.3" "296.8" "285.9" "" "" "" "" "" "" "" "" "" "" "289.6" "250.7" "290.9" "289.2" "269.8" "303.9" "235.9" "289.1" "265.5" "102.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7507804791058133428" "False" "High" "IsMasterProtein" "Q9NX74" "tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens OX=9606 GN=DUS2 PE=1 SV=1" "0.000" "False" "33.352" "19" "8" "11" "8" "493" "55.0" "7.11" "38.99" "8" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035, Pf01207" "54920" "ENSG00000167264" "DUS2" "A8K3G3; hsa:54920; Q4H4D9; Q9NX74" "" "tRNA modification in the nucleus and cytosol; PKR-mediated signaling" "2" "0" "1.066" "1.034" "1.118" "1.041" "1.087" "1.077" "1.000" "1.004" "1.000" "532.1" "567.3" "550.0" "594.9" "553.7" "578.6" "573.3" "532.2" "534.5" "532.1" "" "" "" "" "" "" "" "" "" "" "478.4" "459.0" "497.5" "580.7" "457.0" "578.6" "429.3" "470.1" "478.3" "190.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384522747761550778" "False" "High" "IsMasterProtein" "Q9NUP7" "tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens OX=9606 GN=TRMT13 PE=1 SV=2" "0.000" "False" "33.346" "27" "11" "12" "11" "481" "54.2" "8.09" "37.63" "11" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf05206, Pf05253, Pf11722" "54482" "ENSG00000122435" "TRMT13" "hsa:54482; Q5VVL0; Q9NUP7; Q9NW65" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.994" "0.929" "0.994" "0.987" "0.900" "0.976" "0.996" "0.955" "0.910" "809.8" "805.0" "752.0" "805.2" "799.3" "728.5" "790.1" "806.9" "773.6" "736.6" "" "" "" "" "" "" "" "" "" "" "728.1" "651.3" "680.2" "786.0" "659.6" "728.5" "591.6" "712.7" "692.2" "263.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3312961601966625911" "False" "High" "IsMasterProtein" "Q96EY8" "Corrinoid adenosyltransferase MMAB OS=Homo sapiens OX=9606 GN=MMAB PE=1 SV=1" "0.000" "False" "33.342" "25" "5" "12" "5" "250" "27.4" "8.60" "54.31" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01923" "326625" "ENSG00000139428" "MMAB" "C5HU05; hsa:326625; Q96EY8; Q9BSH0" "Vitamin B12 metabolism" "Cobalamin (Cbl) metabolism; Defective MMAB causes MMA, cblB type" "3" "0" "0.974" "1.020" "1.007" "0.993" "0.996" "1.045" "1.009" "0.990" "0.986" "1028.4" "1001.9" "1048.5" "1036.1" "1021.4" "1024.6" "1074.9" "1037.8" "1017.9" "1013.8" "" "" "" "" "" "" "" "" "" "" "924.6" "810.7" "948.4" "1011.4" "842.9" "1024.6" "804.8" "916.6" "910.8" "361.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3563159699507819169" "False" "High" "IsMasterProtein" "P06280" "Alpha-galactosidase A OS=Homo sapiens OX=9606 GN=GLA PE=1 SV=1" "0.000" "False" "33.321" "18" "7" "11" "7" "429" "48.7" "5.60" "39.18" "7" "other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16499, Pf17450" "2717" "ENSG00000102393" "GLA" "hsa:2717; P06280; Q6LER7" "Degradation pathway of sphingolipids, including diseases; Ciliary landscape" "Neutrophil degranulation; Glycosphingolipid catabolism" "4" "0" "0.986" "0.980" "1.043" "1.018" "1.013" "0.974" "1.005" "1.046" "0.850" "768.4" "757.7" "753.2" "801.8" "782.5" "778.6" "748.3" "772.0" "803.4" "653.1" "" "" "" "" "" "" "" "" "" "" "690.8" "613.1" "681.3" "782.6" "645.8" "778.6" "560.3" "681.9" "718.9" "233.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1767684544015944843" "False" "High" "IsMasterProtein" "P14678" "Small nuclear ribonucleoprotein-associated proteins B and B' OS=Homo sapiens OX=9606 GN=SNRPB PE=1 SV=2" "0.000" "False" "33.304" "24" "6" "22" "6" "240" "24.6" "11.19" "67.05" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6628" "ENSG00000125835" "SNRPB" "hsa:6628; P14678; Q15490; Q6IB35; Q9UIS5" "mRNA processing" "snRNP Assembly; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.954" "0.921" "0.917" "0.967" "0.948" "1.202" "0.922" "0.879" "0.835" "1169.1" "1115.4" "1076.3" "1072.3" "1130.9" "1108.8" "1405.7" "1077.4" "1027.9" "976.1" "" "" "" "" "" "" "" "" "" "" "1051.1" "902.5" "973.5" "1046.7" "933.2" "1108.8" "1052.6" "951.6" "919.8" "348.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8900413936480429684" "False" "High" "IsMasterProtein" "Q9Y6I4" "Ubiquitin carboxyl-terminal hydrolase 3 OS=Homo sapiens OX=9606 GN=USP3 PE=1 SV=2" "0.000" "False" "33.269" "23" "9" "9" "9" "520" "58.9" "8.18" "35.98" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00443, Pf02148" "9960" "ENSG00000140455" "USP3" "B4DVU5; F5H1A6; hsa:9960; Q8WVD0; Q9Y6I4" "" "Ub-specific processing proteases" "1" "0" "0.996" "0.886" "0.993" "0.989" "0.929" "1.026" "0.903" "0.901" "1.009" "342.7" "341.5" "303.7" "340.4" "338.9" "318.5" "351.7" "309.6" "308.7" "345.7" "" "" "" "" "" "" "" "" "" "" "308.1" "276.3" "274.7" "332.2" "279.6" "318.5" "263.3" "273.5" "276.2" "123.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5123694492544734526" "False" "High" "IsMasterProtein" "Q99417" "c-Myc-binding protein OS=Homo sapiens OX=9606 GN=MYCBP PE=1 SV=3" "0.000" "False" "33.251" "65" "6" "11" "6" "103" "12.0" "5.91" "43.70" "6" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "" "26292" "ENSG00000214114" "MYCBP" "B2R4N0; hsa:26292; Q5TA64; Q96HE2; Q99417" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "0.859" "0.927" "0.929" "0.838" "0.856" "0.964" "0.874" "0.874" "0.789" "377.0" "324.0" "349.4" "350.3" "316.0" "322.6" "363.4" "329.6" "329.4" "297.5" "" "" "" "" "" "" "" "" "" "" "339.0" "262.2" "316.1" "341.9" "260.8" "322.6" "272.1" "291.1" "294.7" "106.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3718082725162177882" "False" "High" "IsMasterProtein" "O95822" "Malonyl-CoA decarboxylase, mitochondrial OS=Homo sapiens OX=9606 GN=MLYCD PE=1 SV=3" "0.000" "False" "33.234" "20" "9" "11" "9" "493" "55.0" "8.95" "39.50" "9" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05292, Pf17408" "23417" "ENSG00000103150" "MLYCD" "hsa:23417; O95822; Q9UNU5; Q9Y3F2" "" "" "0" "0" "1.038" "1.003" "0.992" "1.122" "0.968" "1.021" "1.044" "1.028" "0.947" "743.4" "771.6" "745.8" "737.1" "834.4" "719.5" "758.9" "776.2" "764.2" "704.3" "" "" "" "" "" "" "" "" "" "" "668.4" "624.4" "674.6" "719.5" "688.6" "719.5" "568.3" "685.6" "683.8" "251.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7407446589588264140" "False" "High" "IsMasterProtein" "O94763" "Unconventional prefoldin RPB5 interactor 1 OS=Homo sapiens OX=9606 GN=URI1 PE=1 SV=3" "0.000" "False" "33.212" "15" "7" "13" "6" "535" "59.8" "5.05" "48.63" "7" "other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02996" "8725" "ENSG00000105176" "URI1" "A8K805; H7BY42; hsa:8725; O94763; Q8TC23; Q9UNU3" "" "" "0" "0" "1.063" "1.061" "1.019" "1.028" "1.035" "1.028" "0.991" "1.015" "1.087" "586.9" "623.9" "623.0" "598.3" "603.4" "607.3" "603.4" "581.7" "595.8" "638.1" "" "" "" "" "" "" "" "" "" "" "527.7" "504.8" "563.5" "584.0" "498.0" "607.3" "451.8" "513.8" "533.1" "227.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4952075756115425488" "False" "High" "IsMasterProtein" "Cont_P34955" "Alpha-1-antiproteinase OS=Bos taurus OX=9913 GN=SERPINA1 PE=1 SV=1" "0.000" "True" "33.210" "18" "8" "13" "8" "416" "46.1" "6.52" "49.09" "8" "" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "109575576; 280699" "ENSBIXG00000014418; ENSBIXG00005018236; ENSBTAG00000018843" "SERPINA1" "A0A4W2DYT6; A0A6P5DQE7; biu:109575576; bta:280699; P34955; Q3SZS3" "Complement and coagulation cascades; NRF2 pathway" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo concentration in the ER; COPII-mediated vesicle transport" "8" "0" "0.994" "1.078" "1.022" "1.154" "0.980" "1.081" "1.052" "1.025" "0.889" "791.7" "786.9" "853.4" "809.1" "913.6" "775.5" "855.6" "833.2" "811.1" "703.9" "" "" "" "" "" "" "" "" "" "" "711.8" "636.8" "771.9" "789.8" "753.9" "775.5" "640.6" "735.9" "725.7" "251.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1964659957025433859" "False" "High" "IsMasterProtein" "Q9H2H8" "Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens OX=9606 GN=PPIL3 PE=1 SV=1" "0.000" "False" "33.190" "55" "9" "15" "9" "161" "18.1" "6.79" "46.84" "9" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00160" "53938" "ENSG00000240344" "PPIL3" "hsa:53938; Q86WF9; Q96IA9; Q9BXZ1; Q9H2H8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.950" "0.875" "0.956" "0.973" "0.877" "0.938" "0.951" "0.887" "1.119" "1400.0" "1330.3" "1224.8" "1337.7" "1362.7" "1227.5" "1313.8" "1331.4" "1241.5" "1566.2" "" "" "" "" "" "" "" "" "" "" "1258.7" "1076.4" "1107.9" "1305.8" "1124.5" "1227.5" "983.7" "1176.0" "1110.9" "559.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4012099030302879857" "False" "High" "IsMasterProtein" "P49137" "MAP kinase-activated protein kinase 2 OS=Homo sapiens OX=9606 GN=MAPKAPK2 PE=1 SV=1" "0.000" "False" "33.186" "27" "10" "12" "7" "400" "45.5" "8.68" "42.36" "10" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9261" "ENSG00000162889" "MAPKAPK2" "hsa:9261; P49137; Q5SY30; Q5SY41; Q8IYD6" "IL-1 signaling pathway; Microtubule cytoskeleton regulation; Interleukin-1 (IL-1) structural pathway; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway; Pleural mesothelioma; Serotonin HTR1 group and FOS pathway; Serotonin receptor 2 and ELK-SRF/GATA4 signaling; Serotonin receptor 4/6/7 and NR3C signaling" "Oxidative Stress Induced Senescence; Regulation of TNFR1 signaling; activated TAK1 mediates p38 MAPK activation; VEGFA-VEGFR2 Pathway; Regulation of HSF1-mediated heat shock response; p38MAPK events; CREB phosphorylation; Synthesis of Leukotrienes (LT) and Eoxins (EX); Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "21" "2" "0.918" "0.897" "1.001" "0.991" "0.912" "0.920" "0.946" "0.949" "0.991" "750.4" "688.7" "672.9" "751.1" "743.4" "684.6" "690.3" "709.5" "712.4" "743.6" "" "" "" "" "" "" "" "" "" "" "674.6" "557.3" "608.6" "733.2" "613.5" "684.6" "516.9" "626.7" "637.5" "265.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3647234260862617095" "False" "High" "IsMasterProtein" "Q8TEA8" "D-aminoacyl-tRNA deacylase 1 OS=Homo sapiens OX=9606 GN=DTD1 PE=1 SV=2" "0.000" "False" "33.138" "39" "7" "17" "7" "209" "23.4" "8.24" "62.30" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02580" "92675" "ENSG00000125821" "DTD1" "A8K5X5; D3DW37; hsa:92675; Q496D1; Q5W184; Q8TEA8; Q8WXU8; Q9BW67; Q9H464; Q9H474" "" "" "0" "0" "0.980" "1.006" "0.982" "1.029" "0.958" "1.013" "0.990" "0.966" "0.948" "1230.4" "1205.2" "1237.6" "1207.6" "1266.0" "1179.1" "1246.9" "1218.0" "1188.5" "1166.0" "" "" "" "" "" "" "" "" "" "" "1106.2" "975.2" "1119.4" "1178.8" "1044.7" "1179.1" "933.7" "1075.8" "1063.5" "416.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1601999827614054718" "False" "High" "IsMasterProtein" "O95067" "G2/mitotic-specific cyclin-B2 OS=Homo sapiens OX=9606 GN=CCNB2 PE=1 SV=1" "0.000" "False" "33.120" "27" "10" "13" "10" "398" "45.3" "8.90" "35.36" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "9133" "ENSG00000157456" "CCNB2" "B3KM93; hsa:9133; O95067; Q6FI99" "miRNA regulation of DNA damage response; Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; IL-18 signaling pathway; DNA damage response" "Initiation of Nuclear Envelope (NE) Reformation; The role of GTSE1 in G2/M progression after G2 checkpoint; Resolution of Sister Chromatid Cohesion; Nuclear Pore Complex (NPC) Disassembly; Regulation of PLK1 Activity at G2/M Transition; Cyclin A/B1/B2 associated events during G2/M transition; Golgi Cisternae Pericentriolar Stack Reorganization; Polo-like kinase mediated events; Condensation of Prometaphase Chromosomes; Activation of NIMA Kinases NEK9, NEK6, NEK7; G2/M DNA replication checkpoint" "17" "0" "0.986" "1.305" "1.037" "0.996" "1.264" "1.028" "1.029" "1.201" "1.166" "731.6" "721.4" "954.6" "758.8" "728.9" "924.6" "751.7" "752.7" "878.8" "853.3" "" "" "" "" "" "" "" "" "" "" "657.7" "583.8" "863.5" "740.7" "601.5" "924.6" "562.9" "664.9" "786.4" "304.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3725615404801325538" "False" "High" "IsMasterProtein" "Q9UJX3" "Anaphase-promoting complex subunit 7 OS=Homo sapiens OX=9606 GN=ANAPC7 PE=1 SV=5" "0.000" "False" "33.117" "19" "9" "13" "9" "565" "63.1" "5.72" "42.05" "9" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf13181" "" "ENSG00000196510" "ANAPC7" "Q96AC4; Q96GF4; Q9BU24; Q9NT16; Q9UJX3" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.022" "1.044" "0.876" "1.020" "1.042" "1.072" "1.036" "1.030" "1.064" "501.9" "513.0" "524.1" "439.6" "512.0" "522.7" "537.8" "520.0" "516.9" "534.0" "" "" "" "" "" "" "" "" "" "" "451.2" "415.1" "474.0" "429.1" "422.5" "522.7" "402.7" "459.3" "462.5" "190.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1377000983824553191" "False" "High" "IsMasterProtein" "Q8N5N7" "Large ribosomal subunit protein mL50 OS=Homo sapiens OX=9606 GN=MRPL50 PE=1 SV=2" "0.000" "False" "33.080" "43" "6" "11" "6" "158" "18.3" "7.88" "47.88" "6" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf10501" "54534" "ENSG00000136897" "MRPL50" "B7Z358; hsa:54534; Q5T7E0; Q8N5N7; Q9NX15" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.926" "0.974" "0.947" "0.989" "1.012" "0.951" "1.018" "1.041" "0.962" "819.9" "759.0" "798.8" "776.2" "811.2" "830.0" "779.4" "834.9" "853.6" "788.5" "" "" "" "" "" "" "" "" "" "" "737.1" "614.2" "722.5" "757.7" "669.4" "830.0" "583.6" "737.4" "763.8" "281.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876256361286906855" "False" "High" "IsMasterProtein" "P62269" "Small ribosomal subunit protein uS13 OS=Homo sapiens OX=9606 GN=RPS18 PE=1 SV=3" "0.000" "False" "33.070" "41" "9" "15" "9" "152" "17.7" "10.99" "48.89" "9" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00416" "6222" "ENSG00000096150; ENSG00000223367; ENSG00000226225; ENSG00000231500; ENSG00000235650" "RPS18" "hsa:6222; P25232; P62269; Q5SUJ3; Q6IPF8" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.975" "1.015" "0.889" "0.928" "1.044" "0.899" "0.795" "1.008" "1.580" "1360.0" "1326.0" "1380.9" "1209.6" "1261.7" "1419.8" "1222.2" "1081.1" "1370.4" "2148.5" "" "" "" "" "" "" "" "" "" "" "1222.8" "1072.9" "1249.1" "1180.7" "1041.2" "1419.8" "915.1" "954.9" "1226.2" "766.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6197247688658885913" "False" "High" "IsMasterProtein" "Q8N1B4" "Vacuolar protein sorting-associated protein 52 homolog OS=Homo sapiens OX=9606 GN=VPS52 PE=1 SV=1" "0.000" "False" "33.042" "15" "10" "10" "10" "723" "82.2" "5.99" "34.42" "10" "transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04129, Pf20655" "6293" "ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590; ENSG00000228425; ENSG00000236014" "VPS52" "A2BF38; B0UZZ4; B4DNI9; hsa:6293; Q53GR4; Q5JPA0; Q5SQW1; Q8IUN6; Q8N1B4; Q9NPT5" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "1.044" "0.964" "0.932" "1.078" "0.961" "1.026" "1.003" "0.990" "1.077" "1128.8" "1179.1" "1088.4" "1051.7" "1216.6" "1084.8" "1157.9" "1132.4" "1117.6" "1215.5" "" "" "" "" "" "" "" "" "" "" "1014.9" "954.1" "984.5" "1026.6" "1004.0" "1084.8" "867.0" "1000.2" "1000.0" "433.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1760362922626917016" "False" "High" "IsMasterProtein" "Q14011" "Cold-inducible RNA-binding protein OS=Homo sapiens OX=9606 GN=CIRBP PE=1 SV=1" "0.000" "False" "33.009" "39" "5" "17" "5" "172" "18.6" "9.51" "63.83" "5" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "1153" "ENSG00000099622" "CIRBP" "B3KT17; B4E2X2; hsa:1153; Q14011" "" "" "0" "0" "0.976" "0.939" "0.972" "0.917" "0.923" "0.958" "0.981" "0.905" "0.685" "1547.8" "1510.0" "1453.1" "1505.0" "1419.1" "1429.2" "1482.1" "1518.5" "1401.3" "1061.0" "" "" "" "" "" "" "" "" "" "" "1391.7" "1221.8" "1314.3" "1469.1" "1171.0" "1429.2" "1109.8" "1341.3" "1253.8" "378.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551730055028160476" "False" "High" "IsMasterProtein" "P08579" "U2 small nuclear ribonucleoprotein B'' OS=Homo sapiens OX=9606 GN=SNRPB2 PE=1 SV=1" "0.000" "False" "33.008" "31" "7" "23" "5" "225" "25.5" "9.72" "74.71" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6629" "ENSG00000125870" "SNRPB2" "B2R7J3; D3DW21; hsa:6629; P08579; Q9UJD4" "mRNA processing; Ciliary landscape" "mRNA Splicing - Major Pathway" "3" "0" "0.943" "0.894" "0.928" "0.963" "0.950" "0.953" "0.979" "0.884" "0.775" "635.5" "599.3" "568.0" "589.8" "612.2" "603.7" "605.3" "622.4" "561.8" "492.5" "" "" "" "" "" "" "" "" "" "" "571.4" "484.9" "513.8" "575.8" "505.2" "603.7" "453.3" "549.7" "502.7" "175.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6207742459099857160" "False" "High" "IsMasterProtein" "Q9UJ41" "Rab5 GDP/GTP exchange factor OS=Homo sapiens OX=9606 GN=RABGEF1 PE=1 SV=3" "0.000" "False" "32.996" "24" "10" "12" "10" "491" "56.9" "7.02" "44.44" "10" "transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01754, Pf02204, Pf18151" "27342" "ENSG00000154710" "RABGEF1" "B4DZM7; hsa:27342; Q3HKR2; Q3HKR3; Q53FG0; Q9UJ41" "16p11.2 distal deletion syndrome" "RAB GEFs exchange GTP for GDP on RABs; TBC/RABGAPs" "3" "0" "1.082" "1.100" "1.033" "0.993" "0.961" "1.062" "1.058" "1.037" "1.059" "607.1" "657.2" "667.7" "627.5" "602.6" "583.7" "645.0" "642.1" "629.6" "642.8" "" "" "" "" "" "" "" "" "" "" "545.9" "531.8" "604.0" "612.5" "497.3" "583.7" "482.9" "567.2" "563.4" "229.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9072204051848657082" "False" "High" "IsMasterProtein" "O75832" "26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PSMD10 PE=1 SV=1" "0.000" "False" "32.990" "35" "6" "15" "6" "226" "24.4" "6.10" "61.03" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf12796" "5716" "ENSG00000101843" "PSMD10" "hsa:5716; O75832; Q5U0B2; Q8IZK9" "Proteasome degradation; Parkin-ubiquitin proteasomal system pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "61" "0" "0.982" "0.946" "0.973" "1.029" "0.905" "1.036" "1.055" "0.969" "0.945" "1136.6" "1115.9" "1075.3" "1105.6" "1169.7" "1028.8" "1177.0" "1198.7" "1101.4" "1073.8" "" "" "" "" "" "" "" "" "" "" "1022.0" "903.0" "972.6" "1079.2" "965.3" "1028.8" "881.3" "1058.7" "985.5" "383.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3324031393637842436" "False" "High" "IsMasterProtein" "P49458" "Signal recognition particle 9 kDa protein OS=Homo sapiens OX=9606 GN=SRP9 PE=1 SV=2" "0.000" "False" "32.983" "50" "6" "29" "6" "86" "10.1" "7.97" "88.80" "6" "other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf05486" "6726" "ENSG00000143742" "SRP9" "A8K0N0; hsa:6726; P49458; Q6NVX0; Q8WTW0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.941" "0.974" "0.916" "0.936" "0.959" "0.909" "0.977" "0.959" "0.717" "2632.9" "2476.6" "2563.2" "2412.7" "2465.4" "2524.2" "2392.9" "2571.8" "2524.9" "1887.4" "" "" "" "" "" "" "" "" "" "" "2367.2" "2004.0" "2318.5" "2355.1" "2034.5" "2524.2" "1791.7" "2271.6" "2259.2" "673.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695950193153579401" "False" "High" "IsMasterProtein" "Q6VEQ5" "WAS protein family homolog 2 OS=Homo sapiens OX=9606 GN=WASH2P PE=2 SV=2" "0.000" "False" "32.973" "25" "9" "12" "9" "465" "50.3" "5.71" "41.02" "9" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf11945" "" "" "WASH2P" "Q6VEQ5" "" "" "0" "0" "1.076" "1.006" "1.027" "1.103" "1.002" "1.056" "0.997" "1.040" "1.025" "713.2" "767.3" "717.7" "732.4" "786.7" "714.4" "753.4" "710.9" "742.1" "731.2" "" "" "" "" "" "" "" "" "" "" "641.2" "620.9" "649.2" "714.9" "649.2" "714.4" "564.1" "627.9" "664.0" "261.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7938684201688622214" "False" "High" "IsMasterProtein" "Q8NC96" "Adaptin ear-binding coat-associated protein 1 OS=Homo sapiens OX=9606 GN=NECAP1 PE=1 SV=2" "0.000" "False" "32.942" "35" "7" "11" "7" "275" "29.7" "6.80" "34.62" "7" "transport" "other membranes;cytosol" "" "Pf07933" "25977" "ENSG00000089818" "NECAP1" "hsa:25977; Q2NL73; Q5XG95; Q6NWY6; Q8N153; Q8NC96; Q8NCB0; Q9BU52; Q9Y407" "" "Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis" "3" "0" "0.964" "0.970" "1.006" "1.012" "0.988" "1.024" "1.046" "1.009" "0.806" "514.7" "496.2" "499.5" "518.0" "520.9" "508.4" "527.2" "538.5" "519.5" "414.9" "" "" "" "" "" "" "" "" "" "" "462.7" "401.5" "451.8" "505.7" "429.9" "508.4" "394.8" "475.6" "464.9" "148.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4862457629609710254" "False" "High" "IsMasterProtein" "Q5SW79" "Centrosomal protein of 170 kDa OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1" "0.000" "False" "32.936" "8" "11" "12" "11" "1584" "175.2" "7.11" "40.37" "11" "" "cytosol;cytoskeleton;other cell component" "" "Pf00498, Pf15308" "9859" "ENSG00000143702; ENSG00000276725" "CEP170" "hsa:9859; O75058; Q5SW77; Q5SW78; Q5SW79; Q7LGA9; Q86W31; Q9UQ08; Q9UQ09" "Ciliary landscape" "" "1" "0" "1.051" "0.948" "1.071" "1.030" "1.054" "1.140" "0.973" "0.949" "0.945" "683.3" "718.3" "647.5" "731.6" "703.8" "720.0" "778.8" "664.7" "648.2" "645.7" "" "" "" "" "" "" "" "" "" "" "614.4" "581.2" "585.7" "714.2" "580.8" "720.0" "583.1" "587.1" "580.0" "230.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248162455227524541" "False" "High" "IsMasterProtein" "Q92636" "Protein FAN OS=Homo sapiens OX=9606 GN=NSMAF PE=1 SV=2" "0.000" "False" "32.935" "11" "9" "10" "9" "917" "104.3" "6.23" "35.22" "9" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00400, Pf02138, Pf02893" "8439" "ENSG00000035681" "NSMAF" "B4DFB0; E9PCH0; hsa:8439; Q8IW26; Q92636" "TNF-alpha signaling pathway; Orexin receptor pathway" "TNFR1-mediated ceramide production" "3" "0" "1.066" "1.064" "0.956" "1.089" "1.031" "1.066" "1.050" "0.989" "0.925" "279.0" "297.4" "296.8" "266.8" "303.7" "287.5" "297.4" "292.9" "275.9" "258.1" "" "" "" "" "" "" "" "" "" "" "250.9" "240.7" "268.5" "260.4" "250.6" "287.5" "222.7" "258.7" "246.8" "92.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4146618986531713622" "False" "High" "IsMasterProtein" "P46782" "Small ribosomal subunit protein uS7 OS=Homo sapiens OX=9606 GN=RPS5 PE=1 SV=4" "0.000" "False" "32.900" "33" "7" "14" "7" "204" "22.9" "9.72" "48.30" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00177" "6193" "ENSG00000083845" "RPS5" "B2R4T2; hsa:6193; P46782; Q96BN0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.016" "0.981" "0.935" "0.966" "1.089" "0.967" "0.950" "1.004" "1.303" "1069.8" "1087.2" "1049.6" "1000.6" "1033.4" "1165.4" "1034.0" "1016.0" "1073.8" "1393.7" "" "" "" "" "" "" "" "" "" "" "961.8" "879.7" "949.4" "976.7" "852.8" "1165.4" "774.2" "897.4" "960.8" "497.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5857120018545354279" "False" "High" "IsMasterProtein" "Q8NFH3" "Nucleoporin Nup43 OS=Homo sapiens OX=9606 GN=NUP43 PE=1 SV=1" "0.000" "False" "32.872" "23" "8" "13" "8" "380" "42.1" "5.63" "45.51" "8" "cell cycle OR cell proliferation;transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00400" "348995" "ENSG00000120253" "NUP43" "B4E2F0; hsa:348995; Q8NFH3; Q9H8S0" "" "Separation of Sister Chromatids; Regulation of HSF1-mediated heat shock response; SUMOylation of chromatin organization proteins; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Late Events; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; HCMV Early Events; EML4 and NUDC in mitotic spindle formation; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "35" "0" "1.095" "0.996" "0.923" "1.075" "1.029" "1.031" "1.020" "1.036" "0.984" "500.3" "547.7" "498.1" "461.7" "538.0" "514.8" "515.5" "510.5" "518.2" "492.5" "" "" "" "" "" "" "" "" "" "" "449.8" "443.2" "450.6" "450.7" "444.0" "514.8" "386.0" "450.9" "463.7" "175.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1941330484708974901" "False" "High" "IsMasterProtein" "P18621" "Large ribosomal subunit protein uL22 OS=Homo sapiens OX=9606 GN=RPL17 PE=1 SV=3" "0.000" "False" "32.851" "40" "7" "18" "6" "184" "21.4" "10.17" "68.60" "7" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf00237" "6139" "ENSG00000265681" "RPL17" "B2R4H3; B4E3C2; B5ME31; hsa:6139; J3QL51; P18621; Q3KQW2; Q6NZ54; Q7M4M5" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.921" "0.884" "0.914" "0.938" "0.931" "0.875" "0.948" "0.941" "0.946" "1600.6" "1474.7" "1415.3" "1462.3" "1501.8" "1490.3" "1400.8" "1516.8" "1506.1" "1514.8" "" "" "" "" "" "" "" "" "" "" "1439.1" "1193.3" "1280.2" "1427.4" "1239.3" "1490.3" "1048.9" "1339.7" "1347.7" "540.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8244788051015200479" "False" "High" "IsMasterProtein" "O43447" "Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1" "0.000" "False" "32.836" "41" "8" "41" "7" "177" "19.2" "8.07" "94.68" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00160" "10465" "ENSG00000171960" "PPIH" "A6NNE7; hsa:10465; O43447" "" "mRNA Splicing - Major Pathway; SARS-CoV-1 activates/modulates innate immune responses" "2" "0" "0.924" "0.976" "0.992" "1.019" "0.913" "0.948" "0.910" "0.978" "0.831" "1372.2" "1268.0" "1338.7" "1361.8" "1398.2" "1252.8" "1300.3" "1249.1" "1342.6" "1139.8" "" "" "" "" "" "" "" "" "" "" "1233.7" "1026.0" "1210.9" "1329.3" "1153.8" "1252.8" "973.7" "1103.3" "1201.3" "406.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4348390061636338319" "False" "High" "IsMasterProtein" "Q9HAW4" "Claspin OS=Homo sapiens OX=9606 GN=CLSPN PE=1 SV=3" "0.000" "False" "32.786" "8" "9" "10" "9" "1339" "151.0" "4.82" "39.84" "9" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "63967" "ENSG00000092853" "CLSPN" "A6NFL4; hsa:63967; Q1RMC6; Q2KHM3; Q5VYG0; Q6P6H5; Q8IWI1; Q9HAW4" "" "Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Ub-specific processing proteases; Apoptotic cleavage of cellular proteins" "4" "0" "0.910" "1.188" "1.018" "1.017" "1.132" "1.097" "0.959" "1.189" "1.376" "847.2" "770.9" "1006.2" "862.9" "861.3" "959.1" "929.1" "812.8" "1007.8" "1166.1" "" "" "" "" "" "" "" "" "" "" "761.8" "623.8" "910.1" "842.3" "710.8" "959.1" "695.7" "717.9" "901.8" "416.3" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9139245110499108060" "False" "High" "IsMasterProtein" "P32942" "Intercellular adhesion molecule 3 OS=Homo sapiens OX=9606 GN=ICAM3 PE=1 SV=2" "0.000" "False" "32.777" "14" "8" "11" "8" "547" "59.5" "5.43" "37.77" "8" "cell adhesion;transport" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf03921, Pf21146" "3385" "ENSG00000076662" "ICAM3" "hsa:3385; P32942; Q6PD68" "Ebola virus infection in host" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "4" "0" "0.966" "0.987" "0.978" "1.023" "1.060" "1.037" "1.006" "1.090" "0.882" "681.4" "658.3" "672.3" "666.3" "696.9" "722.4" "706.4" "685.5" "742.8" "600.9" "" "" "" "" "" "" "" "" "" "" "612.6" "532.7" "608.1" "650.4" "575.1" "722.4" "528.9" "605.5" "664.6" "214.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3788247885213699411" "False" "High" "IsMasterProtein" "P04233" "HLA class II histocompatibility antigen gamma chain OS=Homo sapiens OX=9606 GN=CD74 PE=1 SV=3" "0.000" "False" "32.774" "26" "7" "12" "7" "296" "33.5" "8.44" "33.36" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00086, Pf08831, Pf09307" "972" "ENSG00000019582" "CD74" "A8K7R1; B4DNE8; D3DQG3; D3DQG4; hsa:972; P04233; Q14597; Q29832; Q5U0J8; Q8SNA0; Q8WLP6" "Macrophage markers" "MHC class II antigen presentation; Cell surface interactions at the vascular wall" "3" "0" "0.926" "0.907" "0.999" "1.008" "0.981" "1.037" "1.011" "0.927" "0.772" "1299.2" "1203.4" "1177.9" "1298.5" "1310.2" "1274.8" "1347.2" "1314.0" "1204.4" "1003.6" "" "" "" "" "" "" "" "" "" "" "1168.1" "973.8" "1065.5" "1267.5" "1081.2" "1274.8" "1008.7" "1160.6" "1077.7" "358.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628427782035597939" "False" "High" "IsMasterProtein" "P20336" "Ras-related protein Rab-3A OS=Homo sapiens OX=9606 GN=RAB3A PE=1 SV=1" "0.000" "False" "32.746" "38" "8" "17" "5" "220" "25.0" "5.03" "51.26" "8" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "5864" "ENSG00000105649" "RAB3A" "A8K0J4; hsa:5864; P20336; Q9NYE1" "Synaptic vesicle pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Intracellular trafficking proteins involved in CMT neuropathy" "Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; Sensory processing of sound by inner hair cells of the cochlea; Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation" "13" "0" "0.961" "0.937" "0.975" "1.034" "0.948" "1.028" "0.962" "0.956" "0.838" "523.5" "503.2" "490.6" "510.7" "541.5" "496.2" "538.0" "503.7" "500.2" "438.9" "" "" "" "" "" "" "" "" "" "" "470.7" "407.2" "443.8" "498.5" "446.9" "496.2" "402.8" "444.9" "447.6" "156.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667668452715930583" "False" "High" "IsMasterProtein" "O60264" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 OS=Homo sapiens OX=9606 GN=SMARCA5 PE=1 SV=1" "0.000" "False" "32.742" "12" "13" "14" "13" "1052" "121.8" "8.09" "40.62" "13" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf09110, Pf09111" "8467" "ENSG00000153147" "SMARCA5" "hsa:8467; O60264" "10q11.21q11.23 copy number variation syndrome" "Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; NoRC negatively regulates rRNA expression" "5" "0" "0.961" "0.854" "0.821" "0.929" "0.746" "0.947" "0.828" "0.796" "1.804" "524.6" "504.4" "448.1" "430.8" "487.6" "391.1" "496.8" "434.3" "417.5" "946.4" "" "" "" "" "" "" "" "" "" "" "471.7" "408.1" "405.3" "420.5" "402.4" "391.1" "372.0" "383.6" "373.6" "337.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3631621731617011436" "False" "High" "IsMasterProtein" "Q12955" "Ankyrin-3 OS=Homo sapiens OX=9606 GN=ANK3 PE=1 SV=3" "0.000" "False" "32.730" "3" "11" "12" "10" "4377" "480.1" "6.49" "35.08" "11" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00531, Pf00791, Pf12796, Pf17809" "288" "ENSG00000151150" "ANK3" "B1AQT2; B4DIL1; E9PE32; hsa:288; Q12955; Q13484; Q5CZH9; Q5VXD5; Q7Z3G4; Q9H0P5" "Splicing factor NOVA regulated synaptic proteins" "COPI-mediated anterograde transport; Interaction between L1 and Ankyrins" "3" "1" "1.121" "1.008" "1.045" "1.174" "0.962" "1.096" "1.103" "1.033" "1.290" "455.6" "510.9" "459.4" "476.0" "534.9" "438.0" "499.3" "502.6" "470.4" "587.6" "" "" "" "" "" "" "" "" "" "" "409.6" "413.4" "415.5" "464.7" "441.4" "438.0" "373.9" "443.9" "420.9" "209.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2583602978446666213" "False" "High" "IsMasterProtein" "O15514" "DNA-directed RNA polymerase II subunit RPB4 OS=Homo sapiens OX=9606 GN=POLR2D PE=1 SV=1" "0.000" "False" "32.716" "66" "7" "12" "7" "142" "16.3" "4.79" "50.68" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf03874" "5433" "ENSG00000144231" "POLR2D" "hsa:5433; O15514; Q52LT4" "Pyrimidine metabolism" "Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "42" "0" "0.890" "1.003" "0.895" "1.000" "1.047" "0.949" "1.036" "1.019" "0.817" "637.9" "567.7" "639.6" "570.9" "637.9" "667.6" "605.2" "661.1" "650.3" "521.2" "" "" "" "" "" "" "" "" "" "" "573.6" "459.4" "578.5" "557.3" "526.4" "667.6" "453.2" "583.9" "581.9" "186.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3197858597980699967" "False" "High" "IsMasterProtein" "Q9HA64" "Ketosamine-3-kinase OS=Homo sapiens OX=9606 GN=FN3KRP PE=1 SV=2" "0.000" "False" "32.716" "31" "8" "12" "8" "309" "34.4" "7.33" "41.81" "8" "protein metabolism;other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf03881" "79672" "ENSG00000141560" "FN3KRP" "hsa:79672; Q969F4; Q9H0U7; Q9HA64" "" "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" "1" "0" "1.038" "1.077" "0.994" "1.169" "1.046" "1.068" "0.984" "1.063" "0.941" "813.8" "845.1" "876.5" "809.2" "951.1" "851.6" "868.9" "800.5" "865.1" "765.9" "" "" "" "" "" "" "" "" "" "" "731.7" "683.8" "792.8" "789.9" "784.8" "851.6" "650.6" "707.1" "774.1" "273.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-917272071926626278" "False" "High" "IsMasterProtein" "Q99797" "Mitochondrial intermediate peptidase OS=Homo sapiens OX=9606 GN=MIPEP PE=1 SV=2" "0.000" "False" "32.639" "16" "11" "12" "10" "713" "80.6" "7.05" "39.99" "11" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01432" "4285" "ENSG00000027001" "MIPEP" "hsa:4285; Q5JV15; Q5T9Q9; Q96G65; Q99797" "13q12.12 copy number variation" "" "1" "0" "1.014" "1.059" "0.986" "0.991" "1.024" "1.085" "1.053" "1.045" "0.987" "930.7" "944.0" "985.6" "917.8" "922.2" "952.6" "1009.9" "980.4" "972.3" "918.9" "" "" "" "" "" "" "" "" "" "" "836.8" "763.9" "891.5" "895.9" "761.0" "952.6" "756.2" "866.0" "870.0" "328.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4946696058487786946" "False" "High" "IsMasterProtein" "Q9UHJ6" "Sedoheptulokinase OS=Homo sapiens OX=9606 GN=SHPK PE=1 SV=4" "0.000" "False" "32.630" "25" "9" "9" "9" "478" "51.5" "6.83" "35.07" "9" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00370" "23729" "ENSG00000197417" "SHPK" "B2R640; Q8WUH3; Q9UHJ6" "" "Pentose phosphate pathway" "1" "0" "1.158" "1.001" "0.990" "1.051" "1.050" "1.094" "1.052" "1.080" "0.904" "306.3" "354.7" "306.7" "303.3" "322.0" "321.5" "335.2" "322.2" "330.7" "277.1" "" "" "" "" "" "" "" "" "" "" "275.4" "287.0" "277.4" "296.1" "265.7" "321.5" "251.0" "284.6" "295.9" "98.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3761626498643372027" "False" "High" "IsMasterProtein" "P05362" "Intercellular adhesion molecule 1 OS=Homo sapiens OX=9606 GN=ICAM1 PE=1 SV=2" "0.000" "False" "32.623" "15" "6" "10" "6" "532" "57.8" "7.99" "38.90" "6" "cell adhesion;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf03921, Pf13895, Pf21146" "3383" "ENSG00000090339" "ICAM1" "B2R6M3; hsa:3383; P05362; Q5NKV7; Q96B50" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; Interleukin-11 signaling pathway; Spinal cord injury; Complement system; IL1 and megakaryocytes in obesity; Photodynamic therapy-induced NF-kB survival signaling; VEGFA-VEGFR2 signaling; miRNA role in immune response in sepsis; Platelet-mediated interactions with vascular and circulating cells; Cells and molecules involved in local acute inflammatory response ; Netrin-UNC5B signaling pathway; IL-18 signaling pathway; CAMKK2 pathway; p53 transcriptional gene network; Orexin receptor pathway; Urotensin-II-mediated signaling pathway; Role of ROS in COVID-19 endothelial dysfunction; IL-26 signaling pathways; Type II interferon signaling" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; Interleukin-10 signaling; Interleukin-4 and Interleukin-13 signaling; Interferon gamma signaling" "27" "0" "0.973" "1.077" "1.000" "1.004" "1.172" "0.999" "1.037" "1.159" "0.751" "581.0" "565.1" "625.5" "581.2" "583.6" "680.9" "580.5" "602.3" "673.1" "436.5" "" "" "" "" "" "" "" "" "" "" "522.4" "457.3" "565.8" "567.3" "481.6" "680.9" "434.7" "531.9" "602.3" "155.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3263618484320997085" "False" "High" "IsMasterProtein" "Q9H098" "Protein FAM107B OS=Homo sapiens OX=9606 GN=FAM107B PE=1 SV=1" "0.000" "False" "32.575" "53" "8" "16" "8" "131" "15.5" "8.29" "54.80" "8" "" "" "" "Pf06625" "83641" "ENSG00000065809" "FAM107B" "A8K1P4; D3DRT2; hsa:83641; Q5T9K7; Q5T9K8; Q6ZSI4; Q9H098" "" "" "0" "0" "0.900" "0.822" "0.921" "0.890" "0.837" "0.853" "0.932" "0.795" "0.660" "2174.7" "1957.0" "1787.4" "2003.1" "1936.2" "1820.7" "1856.0" "2027.5" "1727.9" "1434.8" "" "" "" "" "" "" "" "" "" "" "1955.3" "1583.6" "1616.7" "1955.3" "1597.8" "1820.7" "1389.7" "1790.9" "1546.1" "512.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4655798141038654615" "False" "High" "IsMasterProtein" "Q8N6N3" "UPF0690 protein C1orf52 OS=Homo sapiens OX=9606 GN=C1orf52 PE=1 SV=1" "0.000" "False" "32.547" "34" "8" "14" "8" "182" "20.6" "5.21" "51.27" "8" "" "nucleus" "" "Pf15559" "148423" "ENSG00000162642" "C1orf52" "B3KX89; hsa:148423; Q8N6N3; Q8TDK5; Q8TDK6" "" "" "0" "0" "0.953" "0.978" "0.947" "1.012" "0.981" "1.048" "1.077" "0.977" "0.994" "1281.1" "1220.2" "1252.5" "1213.0" "1297.0" "1257.0" "1342.6" "1379.6" "1251.3" "1274.0" "" "" "" "" "" "" "" "" "" "" "1151.8" "987.4" "1132.9" "1184.0" "1070.3" "1257.0" "1005.3" "1218.5" "1119.7" "454.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7397667510889778360" "False" "High" "IsMasterProtein" "Q9H4X1" "Regulator of cell cycle RGCC OS=Homo sapiens OX=9606 GN=RGCC PE=1 SV=1" "0.000" "False" "32.532" "53" "5" "7" "5" "137" "14.6" "4.75" "37.13" "5" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15151" "28984" "ENSG00000102760" "RGCC" "hsa:28984; Q6NZ48; Q9H4X1; Q9UL69" "" "TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "1" "0" "0.957" "0.755" "0.966" "1.023" "0.779" "0.981" "1.063" "0.782" "0.837" "1119.6" "1071.5" "845.7" "1081.1" "1145.1" "872.3" "1098.1" "1190.4" "875.9" "937.1" "" "" "" "" "" "" "" "" "" "" "1006.6" "867.0" "764.9" "1055.3" "945.0" "872.3" "822.2" "1051.4" "783.7" "334.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3928558694847449526" "False" "High" "IsMasterProtein" "Q9UBQ5" "Eukaryotic translation initiation factor 3 subunit K OS=Homo sapiens OX=9606 GN=EIF3K PE=1 SV=1" "0.000" "False" "32.523" "38" "6" "12" "6" "218" "25.0" "4.93" "39.59" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf10075" "27335" "ENSG00000178982; ENSG00000282986" "EIF3K" "A8K0I9; B7ZAM9; hsa:27335; Q96IQ0; Q9UBQ5; Q9Y6D1" "" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit" "6" "0" "1.009" "1.031" "0.908" "1.032" "1.008" "1.011" "0.969" "1.012" "1.303" "886.9" "894.7" "914.3" "805.3" "915.0" "894.3" "896.8" "859.1" "897.7" "1155.6" "" "" "" "" "" "" "" "" "" "" "797.4" "723.9" "827.0" "786.1" "755.0" "894.3" "671.5" "758.8" "803.3" "412.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "280272277997118017" "False" "High" "IsMasterProtein" "Q9Y316" "Protein MEMO1 OS=Homo sapiens OX=9606 GN=MEMO1 PE=1 SV=1" "0.000" "False" "32.485" "25" "6" "13" "6" "297" "33.7" "7.14" "51.48" "6" "other biological processes" "" "" "Pf01875" "51072" "ENSG00000162959" "MEMO1" "B4DLS0; D6W575; hsa:51072; Q5R2V8; Q5R2V9; Q6NSL5; Q9Y316" "" "ERBB2 Regulates Cell Motility" "1" "0" "1.002" "0.986" "1.082" "1.033" "1.046" "1.075" "1.050" "1.044" "0.889" "721.7" "722.8" "711.8" "781.0" "745.4" "754.6" "775.6" "757.4" "753.7" "641.9" "" "" "" "" "" "" "" "" "" "" "648.8" "584.9" "643.8" "762.3" "615.1" "754.6" "580.7" "669.0" "674.4" "229.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4533705047032389806" "False" "High" "IsMasterProtein" "P62241" "Small ribosomal subunit protein eS8 OS=Homo sapiens OX=9606 GN=RPS8 PE=1 SV=2" "0.000" "False" "32.482" "34" "6" "12" "6" "208" "24.2" "10.32" "45.75" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01201" "6202" "ENSG00000142937" "RPS8" "hsa:6202; P09058; P62241; Q6IRL7" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.861" "0.809" "0.873" "0.839" "0.848" "0.794" "0.835" "0.908" "1.215" "1146.3" "987.5" "926.9" "1001.0" "962.0" "971.6" "909.8" "957.4" "1041.4" "1392.6" "" "" "" "" "" "" "" "" "" "" "1030.7" "799.0" "838.4" "977.1" "793.9" "971.6" "681.3" "845.7" "931.8" "497.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7463306019950863991" "False" "High" "IsMasterProtein" "O60784" "Target of Myb1 membrane trafficking protein OS=Homo sapiens OX=9606 GN=TOM1 PE=1 SV=2" "0.000" "False" "32.456" "20" "7" "8" "7" "492" "53.8" "4.70" "36.43" "7" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00790, Pf03127" "10043" "ENSG00000100284" "TOM1" "B4DEL9; B4DNA1; hsa:10043; O60784; Q5TIJ6; Q86X74" "" "Neutrophil degranulation" "1" "0" "0.960" "1.021" "1.001" "1.061" "0.997" "1.004" "1.026" "1.059" "0.922" "687.3" "659.7" "702.0" "688.1" "729.1" "685.6" "689.8" "705.0" "728.2" "633.6" "" "" "" "" "" "" "" "" "" "" "618.0" "533.8" "635.0" "671.7" "601.6" "685.6" "516.5" "622.7" "651.6" "226.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5215276665585730267" "False" "High" "IsMasterProtein" "Q9BTD8" "RNA-binding protein 42 OS=Homo sapiens OX=9606 GN=RBM42 PE=1 SV=1" "0.000" "False" "32.437" "21" "7" "12" "7" "480" "50.4" "9.63" "46.98" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "79171" "ENSG00000126254" "RBM42" "hsa:79171; O00320; Q8N5R7; Q9BTD8; Q9BU66" "" "mRNA Splicing - Major Pathway" "1" "0" "1.011" "0.980" "0.982" "1.009" "1.037" "0.998" "1.114" "1.032" "1.072" "511.9" "517.3" "501.9" "502.4" "516.5" "531.0" "510.9" "570.3" "528.2" "548.7" "" "" "" "" "" "" "" "" "" "" "460.2" "418.6" "454.0" "490.4" "426.2" "531.0" "382.5" "503.7" "472.7" "195.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2382558777454412534" "False" "High" "IsMasterProtein" "P25686" "DnaJ homolog subfamily B member 2 OS=Homo sapiens OX=9606 GN=DNAJB2 PE=1 SV=3" "0.000" "False" "32.434" "31" "9" "10" "8" "324" "35.6" "5.95" "34.88" "9" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00226" "3300" "ENSG00000135924" "DNAJB2" "A8K9P6; hsa:3300; P25686; Q53QD7; Q8IUK1; Q8IUK2; Q96F52" "" "" "0" "1" "0.945" "0.911" "0.925" "1.047" "0.953" "1.164" "1.069" "1.141" "1.283" "1034.0" "977.3" "942.0" "956.4" "1082.5" "985.4" "1203.2" "1105.6" "1179.9" "1326.3" "" "" "" "" "" "" "" "" "" "" "929.7" "790.8" "852.1" "933.6" "893.3" "985.4" "901.0" "976.6" "1055.8" "473.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "272489793728892869" "False" "High" "IsMasterProtein" "Q14696" "LRP chaperone MESD OS=Homo sapiens OX=9606 GN=MESD PE=1 SV=2" "0.000" "False" "32.378" "41" "9" "13" "9" "234" "26.1" "7.78" "45.37" "9" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf10185" "23184" "ENSG00000117899" "MESD" "B4DW84; D3DW96; hsa:23184; Q14696; Q969U1" "" "" "0" "0" "0.920" "0.968" "0.975" "0.939" "0.923" "0.952" "1.020" "0.919" "0.772" "2024.9" "1862.2" "1960.0" "1974.2" "1901.4" "1868.5" "1928.2" "2066.2" "1860.1" "1563.8" "" "" "" "" "" "" "" "" "" "" "1820.6" "1506.8" "1772.9" "1927.1" "1569.1" "1868.5" "1443.8" "1825.0" "1664.4" "558.2" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8599582728715422228" "False" "High" "IsMasterProtein" "Q01432" "AMP deaminase 3 OS=Homo sapiens OX=9606 GN=AMPD3 PE=1 SV=1" "0.000" "False" "32.359" "13" "10" "11" "9" "767" "88.8" "6.98" "42.23" "10" "other metabolic processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf19326" "272" "ENSG00000133805" "AMPD3" "A0AUX0; B7Z2S2; B7Z763; B7Z877; hsa:272; Q01432" "" "Neutrophil degranulation; Purine salvage" "2" "0" "1.034" "0.952" "1.023" "1.062" "1.050" "1.052" "1.066" "1.012" "0.875" "894.9" "925.7" "852.0" "915.6" "950.2" "939.8" "941.3" "954.2" "905.7" "782.8" "" "" "" "" "" "" "" "" "" "" "804.6" "749.0" "770.6" "893.7" "784.1" "939.8" "704.8" "842.8" "810.5" "279.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7522921008615735421" "False" "High" "IsMasterProtein" "O75152" "Zinc finger CCCH domain-containing protein 11A OS=Homo sapiens OX=9606 GN=ZC3H11A PE=1 SV=3" "0.000" "False" "32.342" "14" "9" "9" "9" "810" "89.1" "8.37" "32.14" "9" "other metabolic processes;transport" "nucleus" "other molecular function" "Pf15663" "9877" "ENSG00000058673" "ZC3H11A" "hsa:9877; O75152; Q6AHY4; Q6AHY9; Q6AW79; Q6AWA1; Q6PJK4; Q86XZ7" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "1.019" "0.975" "1.024" "1.014" "0.979" "1.044" "1.007" "0.968" "1.958" "633.0" "645.0" "617.4" "648.0" "641.7" "619.7" "661.2" "637.5" "613.0" "1239.7" "" "" "" "" "" "" "" "" "" "" "569.1" "521.9" "558.5" "632.6" "529.6" "619.7" "495.1" "563.1" "548.5" "442.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4010780836197462310" "False" "High" "IsMasterProtein" "Q15427" "Splicing factor 3B subunit 4 OS=Homo sapiens OX=9606 GN=SF3B4 PE=1 SV=1" "0.000" "False" "32.341" "18" "5" "8" "5" "424" "44.4" "8.56" "42.69" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00076" "10262" "ENSG00000143368" "SF3B4" "hsa:10262; Q15427; Q5SZ63" "mRNA processing; 10q22q23 copy number variation" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "4" "0" "1.120" "1.100" "1.125" "1.000" "1.190" "0.994" "1.148" "1.138" "0.521" "1008.8" "1129.7" "1109.6" "1135.0" "1008.4" "1200.5" "1003.1" "1158.6" "1148.3" "525.5" "" "" "" "" "" "" "" "" "" "" "907.0" "914.1" "1003.7" "1107.9" "832.2" "1200.5" "751.1" "1023.3" "1027.5" "187.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5329658274444496515" "False" "High" "IsMasterProtein" "O95394" "Phosphoacetylglucosamine mutase OS=Homo sapiens OX=9606 GN=PGM3 PE=1 SV=1" "0.000" "False" "32.337" "21" "10" "11" "10" "542" "59.8" "6.25" "35.31" "10" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00408, Pf02878, Pf21404, Pf21405" "5238" "ENSG00000013375" "PGM3" "B2RB65; B4DX94; D6RF12; E1P547; E9PF86; hsa:5238; O95394; Q5JWR4; Q96J46; Q9H8G5; Q9NS94; Q9NTT6; Q9UFV5; Q9UIY2" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Synthesis of UDP-N-acetyl-glucosamine" "3" "0" "0.986" "1.041" "1.002" "1.017" "1.017" "1.006" "0.957" "1.025" "1.149" "1108.1" "1092.9" "1153.4" "1110.6" "1126.8" "1127.5" "1115.1" "1060.0" "1135.6" "1273.0" "" "" "" "" "" "" "" "" "" "" "996.3" "884.3" "1043.3" "1084.1" "929.9" "1127.5" "834.9" "936.3" "1016.1" "454.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2037005348220660879" "False" "High" "IsMasterProtein" "O00151" "PDZ and LIM domain protein 1 OS=Homo sapiens OX=9606 GN=PDLIM1 PE=1 SV=4" "0.000" "False" "32.292" "31" "8" "13" "8" "329" "36.0" "7.02" "46.57" "8" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595, Pf15936" "9124" "ENSG00000107438" "PDLIM1" "B2RBS6; hsa:9124; O00151; Q5VZH5; Q9BPZ9" "" "" "0" "0" "1.069" "0.945" "0.960" "1.236" "1.217" "1.141" "0.994" "1.177" "0.989" "1258.8" "1345.4" "1189.5" "1209.0" "1555.6" "1531.8" "1436.5" "1251.3" "1481.6" "1245.5" "" "" "" "" "" "" "" "" "" "" "1131.8" "1088.7" "1075.9" "1180.1" "1283.7" "1531.8" "1075.6" "1105.2" "1325.7" "444.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848560432404461068" "False" "High" "IsMasterProtein" "Q16775" "Hydroxyacylglutathione hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HAGH PE=1 SV=2" "0.000" "False" "32.279" "26" "7" "12" "7" "308" "33.8" "8.12" "43.92" "7" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00753, Pf16123" "3029" "ENSG00000063854" "HAGH" "A8K290; B4DP33; B4DRA7; E7EN93; hsa:3029; Q16775" "" "" "0" "0" "0.982" "0.977" "1.000" "0.991" "0.988" "1.038" "0.961" "0.965" "0.959" "788.3" "774.4" "770.1" "788.5" "781.2" "779.1" "818.4" "757.2" "761.0" "755.7" "" "" "" "" "" "" "" "" "" "" "708.7" "626.6" "696.6" "769.6" "644.7" "779.1" "612.8" "668.8" "681.0" "269.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9004188409903141881" "False" "High" "IsMasterProtein" "P52758" "2-iminobutanoate/2-iminopropanoate deaminase OS=Homo sapiens OX=9606 GN=RIDA PE=1 SV=1" "0.000" "False" "32.248" "41" "4" "9" "4" "137" "14.5" "8.68" "37.29" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01042" "10247" "ENSG00000132541" "RIDA" "hsa:10247; P52758; Q6FHU9; Q6IBG0" "" "Threonine catabolism" "1" "0" "0.955" "0.952" "1.039" "1.007" "0.999" "0.951" "1.022" "0.986" "0.747" "1078.1" "1029.3" "1026.4" "1120.3" "1086.1" "1077.3" "1025.2" "1102.1" "1063.5" "805.5" "" "" "" "" "" "" "" "" "" "" "969.3" "832.9" "928.4" "1093.6" "896.3" "1077.3" "767.7" "973.5" "951.6" "287.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6449517754761536848" "False" "High" "IsMasterProtein" "O95619" "YEATS domain-containing protein 4 OS=Homo sapiens OX=9606 GN=YEATS4 PE=1 SV=1" "0.000" "False" "32.212" "33" "9" "13" "9" "227" "26.5" "8.41" "38.82" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03366" "8089" "ENSG00000127337" "YEATS4" "hsa:8089; O95619; Q9NQD0" "" "HATs acetylate histones; Activation of the TFAP2 (AP-2) family of transcription factors" "2" "0" "1.006" "0.890" "0.944" "0.972" "0.899" "0.970" "0.957" "0.882" "0.952" "1667.7" "1677.2" "1484.8" "1573.8" "1620.3" "1499.0" "1616.9" "1596.0" "1470.4" "1587.9" "" "" "" "" "" "" "" "" "" "" "1499.5" "1357.1" "1343.1" "1536.3" "1337.1" "1499.0" "1210.7" "1409.7" "1315.7" "566.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710541814749781042" "False" "High" "IsMasterProtein" "P54619" "5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens OX=9606 GN=PRKAG1 PE=1 SV=1" "0.000" "False" "32.195" "21" "7" "14" "7" "331" "37.6" "6.92" "47.98" "7" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00571" "5571" "ENSG00000181929" "PRKAG1" "B4DDT7; hsa:5571; P54619; Q8N7V9" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Activation of AMPK downstream of NMDARs; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "24" "0" "1.051" "1.072" "0.923" "1.022" "0.968" "1.005" "0.929" "1.022" "0.880" "1013.1" "1064.4" "1085.6" "934.9" "1035.4" "980.2" "1018.3" "941.3" "1035.5" "891.1" "" "" "" "" "" "" "" "" "" "" "910.8" "861.3" "982.0" "912.6" "854.4" "980.2" "762.5" "831.4" "926.6" "318.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8392578490847645683" "False" "High" "IsMasterProtein" "Q9NR33" "DNA polymerase epsilon subunit 4 OS=Homo sapiens OX=9606 GN=POLE4 PE=1 SV=2" "0.000" "False" "32.175" "50" "4" "12" "4" "117" "12.2" "4.92" "48.85" "4" "DNA metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "56655" "ENSG00000115350" "POLE4" "Q53TR2; Q9NR33" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Activation of the pre-replicative complex; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; DNA replication initiation; Gap-filling DNA repair synthesis and ligation in GG-NER" "16" "0" "0.763" "0.948" "0.857" "0.947" "1.028" "0.897" "1.029" "1.063" "1.079" "640.5" "488.9" "607.1" "548.9" "606.6" "658.7" "574.4" "658.8" "681.0" "691.4" "" "" "" "" "" "" "" "" "" "" "575.9" "395.6" "549.2" "535.8" "500.5" "658.7" "430.1" "581.9" "609.3" "246.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1208867046530031718" "False" "High" "IsMasterProtein" "P47813" "Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2" "0.000" "False" "32.170" "40" "7" "17" "1" "144" "16.5" "5.24" "63.66" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity" "Pf01176" "1964" "ENSG00000173674" "EIF1AX" "B2R5U5; hsa:1964; P47813; Q0VGC2; Q5JPS5; Q5JPS6" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition" "8" "0" "0.967" "1.009" "0.892" "0.957" "0.998" "1.165" "1.032" "0.815" "0.551" "133.0" "128.5" "134.2" "118.6" "127.2" "132.7" "154.9" "137.2" "108.3" "73.2" "" "" "" "" "" "" "" "" "" "" "119.5" "104.0" "121.4" "115.8" "105.0" "132.7" "115.9" "121.2" "96.9" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3098042065705187363" "False" "High" "IsMasterProtein" "Q6IBW4" "Condensin-2 complex subunit H2 OS=Homo sapiens OX=9606 GN=NCAPH2 PE=1 SV=1" "0.000" "False" "32.162" "15" "8" "11" "8" "605" "68.2" "4.74" "31.81" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06278, Pf16858, Pf16869" "29781" "ENSG00000025770" "NCAPH2" "B7WPH1; hsa:29781; O43788; Q13391; Q6IBW4; Q96C14; Q96GJ0; Q9BQ71; Q9BUT3; Q9BVD1" "IL-18 signaling pathway" "Condensation of Prophase Chromosomes" "2" "0" "1.112" "1.217" "1.005" "1.117" "1.224" "1.072" "1.097" "1.223" "1.234" "378.4" "421.0" "460.6" "380.2" "422.6" "463.1" "405.6" "415.2" "463.0" "467.1" "" "" "" "" "" "" "" "" "" "" "340.3" "340.6" "416.6" "371.2" "348.7" "463.1" "303.7" "366.7" "414.3" "166.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1272084248319891202" "False" "High" "IsMasterProtein" "Q9UKB1" "F-box/WD repeat-containing protein 11 OS=Homo sapiens OX=9606 GN=FBXW11 PE=1 SV=1" "0.000" "False" "32.132" "18" "9" "9" "9" "542" "62.1" "7.12" "35.19" "9" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf12125, Pf12937" "23291" "ENSG00000072803" "FBXW11" "B2RC98; hsa:23291; Q9P2S8; Q9P2S9; Q9UKB1; Q9Y4C6" "TNF-alpha signaling pathway; VEGFA-VEGFR2 signaling" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; Neddylation; Regulation of PLK1 Activity at G2/M Transition; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "12" "0" "1.011" "1.057" "0.971" "1.070" "1.038" "0.993" "0.998" "1.156" "1.198" "848.3" "857.2" "896.8" "824.0" "907.4" "880.3" "842.0" "846.5" "980.8" "1016.5" "" "" "" "" "" "" "" "" "" "" "762.7" "693.6" "811.2" "804.3" "748.8" "880.3" "630.4" "747.7" "877.6" "362.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8263646129409186084" "False" "High" "IsMasterProtein" "Q14814" "Myocyte-specific enhancer factor 2D OS=Homo sapiens OX=9606 GN=MEF2D PE=1 SV=1" "0.000" "False" "32.127" "15" "7" "15" "5" "521" "55.9" "7.88" "52.14" "7" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4209" "ENSG00000116604; ENSG00000291761" "MEF2D" "D3DVC0; hsa:4209; Q14814; Q14815; Q5T9U5; Q5T9U6" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; B cell receptor signaling pathway; Adipogenesis; p38 MAPK signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; EGF/EGFR signaling pathway; Gastrin signaling pathway; Modulators of TCR signaling and T cell activation; Pleural mesothelioma; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Heme signaling; NGF-stimulated transcription; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Myogenesis" "18" "0" "1.089" "1.020" "1.405" "1.126" "0.990" "1.138" "1.112" "1.063" "1.035" "549.4" "598.5" "560.5" "772.0" "618.9" "544.1" "625.3" "610.9" "584.1" "568.5" "" "" "" "" "" "" "" "" "" "" "494.0" "484.3" "507.0" "753.6" "510.7" "544.1" "468.2" "539.6" "522.7" "203.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201911436176215" "False" "High" "IsMasterProtein" "Q13952" "Nuclear transcription factor Y subunit gamma OS=Homo sapiens OX=9606 GN=NFYC PE=1 SV=3" "0.000" "False" "32.083" "13" "6" "12" "6" "458" "50.3" "6.10" "37.05" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "4802" "ENSG00000066136" "NFYC" "B4DUS6; B4DW63; D3DPV9; F8VWM3; hsa:4802; Q13952; Q59GY4; Q5T6K8; Q5T6K9; Q5T6L1; Q5TZR6; Q92869; Q9HBX1; Q9NXB5; Q9UM67; Q9UML0; Q9UMT7" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "0.966" "0.969" "0.940" "0.994" "0.935" "0.990" "0.965" "0.973" "0.929" "785.6" "758.8" "761.1" "738.4" "781.3" "734.3" "778.1" "758.4" "764.3" "730.2" "" "" "" "" "" "" "" "" "" "" "706.3" "614.0" "688.4" "720.8" "644.7" "734.3" "582.6" "669.8" "683.9" "260.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2873393245892861627" "False" "High" "IsMasterProtein" "Q9UI15" "Transgelin-3 OS=Homo sapiens OX=9606 GN=TAGLN3 PE=1 SV=2" "0.000" "False" "32.081" "14" "2" "26" "1" "199" "22.5" "7.33" "91.16" "2" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus" "cytoskeletal activity" "Pf00307, Pf00402" "29114" "ENSG00000144834" "TAGLN3" "D3DN64; hsa:29114; Q96A74; Q9UI15" "" "" "0" "0" "0.906" "0.931" "0.857" "1.004" "0.903" "0.878" "0.921" "0.944" "0.804" "351.4" "318.4" "327.2" "301.0" "352.7" "317.2" "308.5" "323.7" "331.6" "282.6" "" "" "" "" "" "" "" "" "" "" "315.9" "257.7" "296.0" "293.9" "291.0" "317.2" "231.0" "285.9" "296.7" "100.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5869827592286108947" "False" "High" "IsMasterProtein" "Q9UPQ9" "Trinucleotide repeat-containing gene 6B protein OS=Homo sapiens OX=9606 GN=TNRC6B PE=1 SV=4" "0.000" "False" "32.073" "7" "9" "10" "9" "1833" "193.9" "6.76" "34.85" "9" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf10427, Pf16608" "23112" "ENSG00000100354" "TNRC6B" "B0QY73; B0QY78; B4DGC0; hsa:23112; Q5TH52; Q8TBX2; Q9UPQ9" "" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "18" "0" "0.924" "0.949" "1.008" "1.067" "0.923" "0.926" "0.972" "0.921" "1.078" "383.5" "354.4" "363.8" "386.6" "409.2" "353.9" "355.1" "372.6" "353.3" "413.3" "" "" "" "" "" "" "" "" "" "" "344.8" "286.7" "329.1" "377.4" "337.7" "353.9" "265.9" "329.1" "316.1" "147.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2339365815424834793" "False" "High" "IsMasterProtein" "Q9Y217" "Myotubularin-related protein 6 OS=Homo sapiens OX=9606 GN=MTMR6 PE=1 SV=3" "0.000" "False" "32.072" "18" "9" "14" "9" "621" "71.9" "7.66" "39.14" "9" "protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06602, Pf21098" "9107" "ENSG00000139505" "MTMR6" "B2RBB5; B3KSB4; hsa:9107; Q5JRG6; Q86TB7; Q86YH4; Q96P80; Q9Y217" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane" "2" "0" "0.940" "0.979" "0.934" "1.019" "0.986" "0.941" "0.938" "0.992" "0.879" "491.1" "461.7" "480.8" "458.6" "500.2" "484.3" "462.0" "460.7" "487.0" "431.7" "" "" "" "" "" "" "" "" "" "" "441.6" "373.6" "434.9" "447.7" "412.8" "484.3" "345.9" "406.9" "435.8" "154.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5049084120360688973" "False" "High" "IsMasterProtein" "Q6PL24" "Protein TMED8 OS=Homo sapiens OX=9606 GN=TMED8 PE=1 SV=1" "0.000" "False" "32.042" "25" "7" "10" "7" "325" "35.7" "4.74" "40.28" "7" "" "" "" "Pf13897" "283578" "ENSG00000100580" "TMED8" "B3KTI6; hsa:283578; Q3MJB0; Q6PL24; Q9P1V9" "" "" "0" "0" "0.980" "0.975" "1.014" "0.958" "0.996" "1.006" "0.998" "0.971" "1.696" "1528.4" "1498.2" "1490.0" "1549.5" "1463.6" "1521.5" "1537.5" "1524.9" "1483.7" "2592.8" "" "" "" "" "" "" "" "" "" "" "1374.2" "1212.3" "1347.8" "1512.5" "1207.8" "1521.5" "1151.2" "1346.9" "1327.6" "925.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518477556068487686" "False" "High" "IsMasterProtein" "P30046" "D-dopachrome decarboxylase OS=Homo sapiens OX=9606 GN=DDT PE=1 SV=3" "0.000" "False" "32.011" "51" "6" "21" "6" "118" "12.7" "7.30" "57.57" "6" "other metabolic processes;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "1652" "ENSG00000099977; ENSG00000275003" "DDT" "B7Z522; hsa:1652; O00774; O60787; P30046; Q13534" "" "" "0" "0" "1.025" "1.072" "1.043" "1.074" "0.995" "1.040" "1.023" "1.068" "0.761" "1173.8" "1203.1" "1257.9" "1224.7" "1260.5" "1167.5" "1220.8" "1201.4" "1253.1" "892.8" "" "" "" "" "" "" "" "" "" "" "1055.4" "973.5" "1137.8" "1195.5" "1040.2" "1167.5" "914.1" "1061.1" "1121.3" "318.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5077095867447308247" "False" "High" "IsMasterProtein" "Q9BY77" "Polymerase delta-interacting protein 3 OS=Homo sapiens OX=9606 GN=POLDIP3 PE=1 SV=2" "0.000" "False" "32.006" "29" "9" "9" "9" "421" "46.1" "9.99" "37.85" "9" "other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "84271" "ENSG00000100227" "POLDIP3" "A8K6F8; A8K6V9; hsa:84271; Q009A7; Q5H972; Q6PGN6; Q7Z6Z0; Q9BY77; Q9NSP5; Q9NSP6" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "0.986" "1.037" "1.012" "1.068" "1.075" "1.043" "1.025" "0.950" "0.881" "1133.9" "1118.5" "1175.6" "1147.0" "1211.2" "1219.4" "1182.8" "1162.6" "1076.9" "998.8" "" "" "" "" "" "" "" "" "" "" "1019.4" "905.1" "1063.4" "1119.7" "999.5" "1219.4" "885.7" "1026.9" "963.6" "356.5" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9156757260988577689" "False" "High" "IsMasterProtein" "P0DJD0" "RANBP2-like and GRIP domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RGPD1 PE=2 SV=1" "0.000" "False" "31.984" "5" "10" "11" "1" "1748" "196.5" "6.14" "40.82" "10" "transport" "nucleus;other cell component" "" "Pf00638, Pf01465, Pf16704" "400966" "" "RGPD1" "hsa:400966; P0C839; P0DJD0; Q68DN6; Q6V1X0" "" "" "0" "0" "1.123" "1.074" "1.053" "1.111" "0.939" "1.522" "1.241" "0.935" "4.811" "34.0" "38.2" "36.6" "35.9" "37.8" "32.0" "51.8" "42.2" "31.8" "163.7" "" "" "" "" "" "" "" "" "" "" "30.6" "30.9" "33.1" "35.0" "31.2" "32.0" "38.8" "37.3" "28.5" "58.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7765133988428364561" "False" "High" "IsMasterProtein" "Q58WW2" "DDB1- and CUL4-associated factor 6 OS=Homo sapiens OX=9606 GN=DCAF6 PE=1 SV=1" "0.000" "False" "31.956" "10" "8" "11" "8" "860" "96.2" "5.27" "33.63" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "55827" "ENSG00000143164" "DCAF6" "A2A295; B4DNB8; hsa:55827; Q58WW2; Q7L8I0; Q8IXH3; Q8TB19" "" "Neddylation" "1" "0" "1.056" "0.996" "0.864" "1.003" "0.917" "0.958" "0.964" "0.924" "0.812" "994.6" "1050.0" "990.3" "859.3" "998.0" "911.7" "952.8" "958.6" "919.4" "807.2" "" "" "" "" "" "" "" "" "" "" "894.3" "849.6" "895.8" "838.8" "823.6" "911.7" "713.4" "846.7" "822.7" "288.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1882529908578060163" "False" "High" "IsMasterProtein" "Q9HAS0" "Protein Njmu-R1 OS=Homo sapiens OX=9606 GN=C17orf75 PE=1 SV=2" "0.000" "False" "31.913" "18" "6" "9" "6" "396" "44.6" "5.03" "35.21" "6" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf15053" "64149" "ENSG00000108666" "C17orf75" "hsa:64149; Q7Z2H4; Q9HAS0" "" "" "0" "0" "0.989" "1.026" "0.948" "1.035" "1.004" "1.052" "0.997" "0.975" "1.004" "627.0" "620.3" "643.1" "594.7" "649.0" "629.4" "659.9" "625.3" "611.3" "629.3" "" "" "" "" "" "" "" "" "" "" "563.7" "501.9" "581.7" "580.5" "535.6" "629.4" "494.1" "552.3" "547.0" "224.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1714630333721311506" "False" "High" "IsMasterProtein" "Q6NVY1" "3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Homo sapiens OX=9606 GN=HIBCH PE=1 SV=2" "0.000" "False" "31.900" "23" "9" "11" "9" "386" "43.5" "8.19" "40.99" "9" "other metabolic processes" "mitochondrion" "other molecular function" "Pf16113" "26275" "ENSG00000198130" "HIBCH" "D3DPI4; hsa:26275; Q53GA8; Q53GF2; Q53RF7; Q53TC6; Q6NVY1; Q92931; Q9BS94" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "0.947" "0.977" "0.924" "0.972" "0.864" "0.979" "0.972" "0.957" "0.958" "1353.8" "1281.4" "1323.0" "1250.5" "1315.6" "1169.9" "1325.9" "1315.6" "1295.0" "1297.1" "" "" "" "" "" "" "" "" "" "" "1217.2" "1036.9" "1196.7" "1220.6" "1085.6" "1169.9" "992.8" "1162.0" "1158.7" "463.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5418508312129097166" "False" "High" "IsMasterProtein" "P35626" "G protein-coupled receptor kinase 3 OS=Homo sapiens OX=9606 GN=GRK3 PE=1 SV=2" "0.000" "False" "31.888" "13" "8" "12" "1" "688" "79.7" "7.62" "44.91" "8" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00615" "157" "ENSG00000100077" "GRK3" "hsa:157; P35626; Q9UGW9" "Corticotropin-releasing hormone signaling pathway; Hedgehog signaling pathway" "G alpha (s) signalling events; Cargo recognition for clathrin-mediated endocytosis" "4" "0" "1.227" "1.192" "1.110" "1.071" "1.022" "1.204" "1.021" "1.034" "1.569" "51.2" "62.8" "61.0" "56.8" "54.8" "52.3" "61.6" "52.3" "52.9" "80.3" "" "" "" "" "" "" "" "" "" "" "46.0" "50.8" "55.2" "55.4" "45.2" "52.3" "46.1" "46.2" "47.4" "28.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8867340794532680383" "False" "High" "IsMasterProtein" "O94967" "WD repeat-containing protein 47 OS=Homo sapiens OX=9606 GN=WDR47 PE=1 SV=1" "0.000" "False" "31.879" "11" "10" "12" "10" "919" "101.9" "5.94" "39.20" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "" "Pf00400, Pf17814" "22911" "ENSG00000085433" "WDR47" "A8MX09; hsa:22911; O94967; Q5TYV7; Q5TYV8; Q5TYV9; Q8IXT7; Q8IYU9" "" "" "0" "0" "0.924" "1.037" "0.984" "1.001" "0.977" "0.902" "0.946" "1.029" "0.790" "488.4" "451.2" "506.4" "480.4" "489.1" "477.0" "440.4" "462.3" "502.5" "386.1" "" "" "" "" "" "" "" "" "" "" "439.1" "365.1" "458.0" "469.0" "403.6" "477.0" "329.8" "408.3" "449.7" "137.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4327969175985067622" "False" "High" "IsMasterProtein" "Q6I9Y2" "THO complex subunit 7 homolog OS=Homo sapiens OX=9606 GN=THOC7 PE=1 SV=3" "0.000" "False" "31.852" "41" "9" "10" "9" "204" "23.7" "5.67" "40.10" "9" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05615" "80145" "ENSG00000163634" "THOC7" "hsa:80145; Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "3" "0" "0.878" "0.920" "0.933" "0.937" "0.891" "0.910" "0.935" "0.928" "0.870" "1184.3" "1040.1" "1089.8" "1104.9" "1110.2" "1054.9" "1077.2" "1107.8" "1099.2" "1030.0" "" "" "" "" "" "" "" "" "" "" "1064.8" "841.6" "985.8" "1078.5" "916.2" "1054.9" "806.6" "978.5" "983.6" "367.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8197939441703168183" "False" "High" "IsMasterProtein" "Cont_P12763" "Alpha-2-HS-glycoprotein OS=Bos taurus OX=9913 GN=AHSG PE=1 SV=2" "0.000" "True" "31.848" "24" "7" "10" "7" "359" "38.4" "5.50" "44.15" "7" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00031" "280988" "ENSBTAG00000000522" "AHSG" "A6QLF7; B0JYN6; bta:280988; P12763" "" "Neutrophil degranulation; Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "1.017" "0.798" "1.218" "1.842" "0.908" "0.917" "1.383" "0.801" "0.946" "1138.0" "1157.2" "908.5" "1386.4" "2096.3" "1032.8" "1043.5" "1573.7" "911.3" "1076.5" "" "" "" "" "" "" "" "" "" "" "1023.2" "936.3" "821.7" "1353.3" "1729.9" "1032.8" "781.4" "1390.0" "815.4" "384.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993927886623036395" "False" "High" "IsMasterProtein" "P31947" "14-3-3 protein sigma OS=Homo sapiens OX=9606 GN=SFN PE=1 SV=1" "0.000" "False" "31.834" "18" "6" "91" "1" "248" "27.8" "4.74" "273.14" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00244" "2810" "ENSG00000175793" "SFN" "hsa:2810; P31947; Q6FH30; Q6FH51; Q96DH0" "miRNA regulation of DNA damage response; Cell cycle; Myometrial relaxation and contraction pathways; p53 transcriptional gene network; Calcium regulation in cardiac cells; 7q11.23 distal copy number variation; DNA damage response" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of localization of FOXO transcription factors; TP53 Regulates Metabolic Genes; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex; RHO GTPases activate PKNs; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; Activation of BAD and translocation to mitochondria ; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest" "16" "0" "1.648" "1.259" "0.890" "1.129" "1.271" "1.220" "0.832" "1.262" "1.110" "52.9" "87.2" "66.7" "47.1" "59.8" "67.3" "64.6" "44.0" "66.8" "58.8" "" "" "" "" "" "" "" "" "" "" "47.6" "70.6" "60.3" "46.0" "49.3" "67.3" "48.4" "38.9" "59.8" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7020268087964795198" "False" "High" "IsMasterProtein" "Q9Y3B7" "Large ribosomal subunit protein uL11m OS=Homo sapiens OX=9606 GN=MRPL11 PE=1 SV=1" "0.000" "False" "31.799" "49" "9" "10" "9" "192" "20.7" "9.91" "37.82" "9" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00298, Pf03946" "65003" "ENSG00000174547" "MRPL11" "A6NLT0; A8K219; hsa:65003; Q32P46; Q96Q73; Q9Y3B7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.038" "0.931" "1.025" "1.039" "1.013" "1.040" "1.049" "1.007" "1.475" "932.1" "967.6" "868.0" "955.2" "968.0" "944.7" "969.0" "977.5" "938.5" "1375.0" "" "" "" "" "" "" "" "" "" "" "838.1" "783.0" "785.2" "932.4" "798.9" "944.7" "725.6" "863.4" "839.8" "490.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5626279923656509616" "False" "High" "IsMasterProtein" "P25325" "3-mercaptopyruvate sulfurtransferase OS=Homo sapiens OX=9606 GN=MPST PE=1 SV=3" "0.000" "False" "31.759" "38" "9" "10" "9" "297" "33.2" "6.60" "38.68" "9" "other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00581" "4357" "ENSG00000128309" "MPST" "A8MZ34; B3KP52; hsa:4357; J3KPV7; O75750; P25325; Q6FHN9" "Trans-sulfuration pathway; Amino acid metabolism" "Degradation of cysteine and homocysteine" "3" "0" "0.983" "0.967" "0.929" "0.995" "0.939" "0.943" "0.976" "0.936" "0.924" "1248.5" "1227.6" "1207.7" "1160.2" "1241.9" "1172.5" "1177.7" "1218.2" "1169.0" "1153.0" "" "" "" "" "" "" "" "" "" "" "1122.5" "993.3" "1092.4" "1132.5" "1024.8" "1172.5" "881.9" "1076.0" "1046.1" "411.6" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196663768808374141" "False" "High" "IsMasterProtein" "Q9UBP6" "tRNA (guanine-N(7)-)-methyltransferase OS=Homo sapiens OX=9606 GN=METTL1 PE=1 SV=1" "0.000" "False" "31.731" "30" "7" "12" "7" "276" "31.5" "7.64" "43.36" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02390" "4234" "ENSG00000037897" "METTL1" "B2RBX1; H7BXF2; hsa:4234; Q14105; Q53FS9; Q9UBP6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.999" "0.997" "0.957" "1.018" "0.990" "0.946" "1.002" "0.963" "0.863" "741.9" "741.4" "740.0" "710.0" "755.5" "734.3" "701.5" "743.4" "714.8" "640.3" "" "" "" "" "" "" "" "" "" "" "667.0" "599.9" "669.3" "693.0" "623.4" "734.3" "525.2" "656.7" "639.6" "228.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6259860464076082435" "False" "High" "IsMasterProtein" "Q9NR31" "Small COPII coat GTPase SAR1A OS=Homo sapiens OX=9606 GN=SAR1A PE=1 SV=1" "0.000" "False" "31.724" "32" "6" "17" "3" "198" "22.4" "6.68" "56.68" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00025" "56681" "ENSG00000079332" "SAR1A" "B4DQ19; hsa:56681; Q9NR31" "Sterol regulatory element-binding proteins (SREBP) signaling" "" "1" "0" "1.056" "1.037" "1.083" "0.997" "0.922" "1.006" "1.038" "1.108" "0.952" "827.1" "873.0" "858.1" "895.9" "824.4" "762.6" "831.8" "858.4" "916.5" "787.2" "" "" "" "" "" "" "" "" "" "" "743.6" "706.4" "776.2" "874.5" "680.3" "762.6" "622.8" "758.2" "820.1" "281.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062207759292809652" "False" "High" "IsMasterProtein" "Q13191" "E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens OX=9606 GN=CBLB PE=1 SV=2" "0.000" "False" "31.709" "13" "10" "11" "6" "982" "109.4" "7.88" "34.23" "10" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "signal transduction activity or receptor binding;other molecular function" "Pf00097, Pf02262, Pf02761, Pf02762" "868" "ENSG00000114423" "CBLB" "A8K9S7; B7WNM4; Q13191; Q13192; Q13193; Q3LIC0; Q63Z43; Q8IVC5" "Angiopoietin-like protein 8 regulatory pathway; Fibrin complement receptor 3 signaling pathway; EGF/EGFR signaling pathway; Measles virus infection; Insulin signaling; Modulators of TCR signaling and T cell activation; ErbB signaling pathway; T-cell receptor signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation" "9" "0" "1.034" "1.018" "0.883" "1.084" "0.989" "1.010" "0.972" "0.955" "1.048" "433.5" "448.3" "441.2" "382.6" "469.9" "428.7" "438.0" "421.3" "413.8" "454.2" "" "" "" "" "" "" "" "" "" "" "389.8" "362.7" "399.1" "373.5" "387.8" "428.7" "328.0" "372.1" "370.3" "162.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1080022240978719765" "False" "High" "IsMasterProtein" "P49721" "Proteasome subunit beta type-2 OS=Homo sapiens OX=9606 GN=PSMB2 PE=1 SV=1" "0.000" "False" "31.701" "29" "6" "23" "6" "201" "22.8" "7.02" "76.55" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00227" "5690" "ENSG00000126067" "PSMB2" "D3DPS0; hsa:5690; P31145; P49721; Q9BWZ9" "Proteasome degradation; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Regulation of expression of SLITs and ROBOs; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "62" "0" "1.055" "1.002" "0.956" "0.990" "0.928" "0.959" "1.002" "0.970" "0.819" "2757.3" "2908.7" "2763.4" "2635.1" "2730.3" "2559.2" "2643.4" "2762.9" "2673.9" "2257.3" "" "" "" "" "" "" "" "" "" "" "2479.1" "2353.6" "2499.6" "2572.2" "2253.1" "2559.2" "1979.3" "2440.4" "2392.6" "805.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8637323044109722120" "False" "High" "IsMasterProtein" "Q2NKX8" "DNA excision repair protein ERCC-6-like OS=Homo sapiens OX=9606 GN=ERCC6L PE=1 SV=1" "0.000" "False" "31.692" "10" "9" "10" "9" "1250" "141.0" "5.31" "33.93" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271" "54821" "ENSG00000186871" "ERCC6L" "hsa:54821; Q2NKX8; Q8NCI1; Q96H93; Q9NXQ8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.982" "1.052" "0.992" "0.987" "1.046" "1.045" "0.936" "1.046" "1.972" "1060.0" "1040.7" "1114.8" "1051.9" "1046.6" "1109.1" "1107.6" "992.0" "1108.3" "2090.6" "" "" "" "" "" "" "" "" "" "" "953.1" "842.1" "1008.4" "1026.8" "863.7" "1109.1" "829.4" "876.2" "991.7" "746.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-93736052394886069" "False" "High" "IsMasterProtein" "P50583" "Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] OS=Homo sapiens OX=9606 GN=NUDT2 PE=1 SV=3" "0.000" "False" "31.686" "61" "8" "12" "8" "147" "16.8" "5.35" "40.72" "8" "other metabolic processes;stress response;other biological processes" "mitochondrion" "other molecular function" "Pf00293" "318" "ENSG00000164978" "NUDT2" "D3DRM0; hsa:318; P50583; Q5T589" "" "Detoxification of Reactive Oxygen Species" "1" "0" "1.034" "0.998" "0.962" "1.033" "1.041" "1.028" "1.048" "0.986" "0.965" "760.3" "786.2" "759.0" "731.1" "785.1" "791.4" "781.9" "797.1" "749.8" "734.0" "" "" "" "" "" "" "" "" "" "" "683.6" "636.1" "686.5" "713.6" "647.9" "791.4" "585.4" "704.0" "670.9" "262.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5860754846925802701" "False" "High" "IsMasterProtein" "O95400" "CD2 antigen cytoplasmic tail-binding protein 2 OS=Homo sapiens OX=9606 GN=CD2BP2 PE=1 SV=1" "0.000" "False" "31.686" "23" "5" "8" "5" "341" "37.6" "4.61" "30.58" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02213" "10421" "ENSG00000169217" "CD2BP2" "B2RDX2; hsa:10421; O95400; Q9ULP2" "mRNA processing; Ciliary landscape" "" "2" "0" "0.847" "0.833" "0.800" "0.894" "0.853" "0.909" "0.804" "0.721" "1.144" "270.1" "228.8" "225.1" "216.2" "241.4" "230.4" "245.6" "217.3" "194.8" "309.0" "" "" "" "" "" "" "" "" "" "" "242.9" "185.1" "203.6" "211.0" "199.2" "230.4" "183.9" "191.9" "174.3" "110.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5100210059596347713" "False" "High" "IsMasterProtein" "P04899" "Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Homo sapiens OX=9606 GN=GNAI2 PE=1 SV=3" "0.000" "False" "31.682" "28" "7" "9" "4" "355" "40.4" "5.54" "34.35" "7" "cell-cell signaling;cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2771" "ENSG00000114353" "GNAI2" "B3KTZ0; B4DYA0; B4E2X5; hsa:2771; P04899; Q6B6N3; Q8IZ71" "Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Opioid receptor pathways; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Adrenaline,noradrenaline inhibits insulin secretion" "22" "2" "1.033" "0.996" "1.041" "1.034" "0.978" "0.992" "1.018" "1.139" "0.999" "678.2" "700.3" "675.7" "706.1" "701.4" "663.4" "672.6" "690.2" "772.2" "677.2" "" "" "" "" "" "" "" "" "" "" "609.8" "566.7" "611.2" "689.3" "578.8" "663.4" "503.6" "609.6" "690.9" "241.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5991678768207076864" "False" "High" "IsMasterProtein" "Q9UNF1" "Melanoma-associated antigen D2 OS=Homo sapiens OX=9606 GN=MAGED2 PE=1 SV=2" "0.000" "False" "31.667" "17" "8" "9" "8" "606" "64.9" "9.32" "36.69" "8" "transport;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "" "Pf01454" "10916" "ENSG00000102316" "MAGED2" "A6NMX0; hsa:10916; O76058; Q5BJF3; Q8NAL6; Q9H218; Q9P0U9; Q9UM52; Q9UNF1" "" "Platelet degranulation" "1" "0" "0.980" "1.005" "0.962" "0.984" "1.030" "0.992" "0.935" "1.032" "3.586" "841.4" "824.4" "845.4" "809.1" "828.1" "866.7" "834.8" "786.9" "868.4" "3017.5" "" "" "" "" "" "" "" "" "" "" "756.5" "667.1" "764.7" "789.8" "683.4" "866.7" "625.0" "695.0" "777.0" "1077.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9074819377594512916" "False" "High" "IsMasterProtein" "Q9BQ67" "Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=GRWD1 PE=1 SV=1" "0.000" "False" "31.652" "24" "5" "7" "5" "446" "49.4" "4.92" "35.03" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf12265" "83743" "ENSG00000105447" "GRWD1" "A0MNN5; hsa:83743; Q8TF59; Q9BQ67" "" "" "0" "0" "1.115" "1.070" "0.931" "1.096" "1.090" "1.130" "0.989" "1.126" "1.063" "316.9" "353.3" "339.2" "295.0" "347.2" "345.6" "358.0" "313.3" "356.9" "336.9" "" "" "" "" "" "" "" "" "" "" "284.9" "285.9" "306.8" "288.0" "286.6" "345.6" "268.1" "276.8" "319.3" "120.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5255338936326354588" "False" "High" "IsMasterProtein" "O75448" "Mediator of RNA polymerase II transcription subunit 24 OS=Homo sapiens OX=9606 GN=MED24 PE=1 SV=1" "0.000" "False" "31.648" "10" "8" "10" "8" "989" "110.2" "6.95" "37.72" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11277" "9862" "ENSG00000008838" "MED24" "A8K4S5; B3KMR9; hsa:9862; O75448; Q14143; Q9NNY5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.927" "0.877" "0.765" "0.882" "0.955" "0.896" "0.782" "0.860" "0.925" "584.9" "542.3" "512.9" "447.5" "515.9" "558.6" "523.9" "457.2" "502.8" "540.9" "" "" "" "" "" "" "" "" "" "" "525.9" "438.8" "464.0" "436.8" "425.8" "558.6" "392.3" "403.8" "449.9" "193.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3969710029576412220" "False" "High" "IsMasterProtein" "Q9Y3T6" "R3H and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HCC1 PE=1 SV=3" "0.000" "False" "31.610" "24" "9" "11" "9" "440" "49.1" "5.63" "37.47" "9" "" "" "nucleic acid binding activity" "Pf01424" "203069" "ENSG00000104679" "R3HCC1" "B7ZLI1; hsa:203069; Q9Y3T6" "" "" "0" "0" "1.039" "1.063" "0.978" "1.005" "1.060" "1.062" "1.058" "1.048" "1.068" "971.9" "1009.3" "1033.2" "950.2" "976.8" "1030.4" "1032.4" "1027.9" "1018.9" "1037.7" "" "" "" "" "" "" "" "" "" "" "873.8" "816.7" "934.6" "927.6" "806.0" "1030.4" "773.1" "907.9" "911.7" "370.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514790625548438605" "False" "High" "IsMasterProtein" "Q8WUX2" "Glutathione-specific gamma-glutamylcyclotransferase 2 OS=Homo sapiens OX=9606 GN=CHAC2 PE=1 SV=1" "0.000" "False" "31.594" "41" "6" "9" "6" "184" "20.9" "5.43" "35.70" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf04752" "494143" "ENSG00000143942" "CHAC2" "hsa:494143; Q8WUX2; Q8WVI8" "" "Glutathione synthesis and recycling" "1" "0" "0.966" "1.074" "1.114" "0.990" "1.024" "0.953" "0.983" "1.084" "0.954" "473.7" "457.8" "508.9" "527.6" "468.8" "485.2" "451.6" "465.6" "513.4" "452.1" "" "" "" "" "" "" "" "" "" "" "425.9" "370.4" "460.3" "515.0" "386.9" "485.2" "338.1" "411.3" "459.4" "161.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2241526083572897290" "False" "High" "IsMasterProtein" "Q9ULX6" "A-kinase anchor protein 8-like OS=Homo sapiens OX=9606 GN=AKAP8L PE=1 SV=4" "0.000" "False" "31.589" "16" "10" "11" "10" "646" "71.6" "5.05" "40.68" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "26993" "ENSG00000011243" "AKAP8L" "B4DJ74; B5BU90; hsa:26993; O94792; Q96J58; Q9NRQ0; Q9UGM0; Q9ULX6" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "0.982" "0.951" "0.920" "0.988" "0.958" "1.052" "0.956" "0.958" "2.173" "739.1" "725.8" "702.7" "680.3" "730.5" "707.8" "777.5" "706.4" "708.1" "1606.0" "" "" "" "" "" "" "" "" "" "" "664.5" "587.3" "635.6" "664.0" "602.8" "707.8" "582.2" "623.9" "633.6" "573.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "783704005019212775" "False" "High" "IsMasterProtein" "Q8IZ21" "Phosphatase and actin regulator 4 OS=Homo sapiens OX=9606 GN=PHACTR4 PE=1 SV=1" "0.000" "False" "31.589" "14" "8" "10" "8" "702" "78.2" "6.62" "33.69" "8" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf02755" "65979" "ENSG00000204138" "PHACTR4" "A2APK6; B9ZVW0; D3DPM3; hsa:65979; Q68DD4; Q6NUN6; Q8IZ21; Q8N384; Q9H395; Q9H6X0; Q9H8W6" "" "" "0" "0" "0.943" "0.956" "1.020" "1.047" "1.007" "1.048" "1.093" "1.077" "0.854" "363.2" "342.4" "347.4" "370.6" "380.3" "365.6" "380.8" "397.0" "391.2" "310.2" "" "" "" "" "" "" "" "" "" "" "326.6" "277.1" "314.2" "361.7" "313.8" "365.6" "285.1" "350.7" "350.1" "110.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7232907791819213920" "False" "High" "IsMasterProtein" "Q9Y5Z4" "Heme-binding protein 2 OS=Homo sapiens OX=9606 GN=HEBP2 PE=1 SV=1" "0.000" "False" "31.573" "40" "7" "9" "7" "205" "22.9" "4.63" "37.39" "7" "" "non-structural extracellular;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04832" "23593" "ENSG00000051620" "HEBP2" "hsa:23593; Q96P57; Q9Y5Z4" "" "Neutrophil degranulation" "1" "0" "0.946" "0.945" "0.955" "0.950" "0.966" "0.930" "0.957" "1.000" "0.793" "1133.0" "1071.9" "1070.5" "1081.8" "1076.8" "1094.2" "1053.4" "1084.4" "1133.3" "898.3" "" "" "" "" "" "" "" "" "" "" "1018.7" "867.3" "968.3" "1056.0" "888.6" "1094.2" "788.8" "957.8" "1014.1" "320.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5853240527723212968" "False" "High" "IsMasterProtein" "Q9H7Z7" "Prostaglandin E synthase 2 OS=Homo sapiens OX=9606 GN=PTGES2 PE=1 SV=1" "0.000" "False" "31.572" "27" "8" "10" "8" "377" "41.9" "9.16" "40.44" "8" "other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf13410, Pf13417" "80142" "ENSG00000148334" "PTGES2" "hsa:80142; Q53EW9; Q5SYV6; Q96GI0; Q96GL2; Q9H7Z7" "Relationship between inflammation, COX-2 and EGFR; Omega-6-fatty acids in senescence" "Neutrophil degranulation; Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "1.048" "1.049" "1.054" "0.987" "1.010" "0.988" "1.036" "1.059" "0.773" "913.8" "957.9" "958.5" "963.5" "901.8" "923.0" "902.7" "946.2" "968.1" "706.4" "" "" "" "" "" "" "" "" "" "" "821.6" "775.1" "867.0" "940.5" "744.2" "923.0" "675.9" "835.8" "866.3" "252.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4447457189107336251" "False" "High" "IsMasterProtein" "O60493" "Sorting nexin-3 OS=Homo sapiens OX=9606 GN=SNX3 PE=1 SV=3" "0.000" "False" "31.514" "36" "6" "15" "4" "162" "18.8" "8.66" "38.17" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787" "8724" "ENSG00000112335" "SNX3" "A8K0B1; E1P5E4; E1P5E5; hsa:8724; O60493; O60718; Q4TT29; Q4TT31; Q5JXJ7; Q5JXJ8; Q96AP9; Q9C0J5; Q9NU45" "" "Ub-specific processing proteases; WNT ligand biogenesis and trafficking" "2" "0" "0.980" "0.976" "0.908" "1.014" "1.020" "0.976" "0.998" "1.003" "2.567" "457.9" "448.7" "447.2" "415.8" "464.5" "467.2" "446.9" "457.0" "459.3" "1175.6" "" "" "" "" "" "" "" "" "" "" "411.7" "363.0" "404.5" "405.9" "383.3" "467.2" "334.6" "403.6" "411.0" "419.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5155365173843636052" "False" "High" "IsMasterProtein" "P48507" "Glutamate--cysteine ligase regulatory subunit OS=Homo sapiens OX=9606 GN=GCLM PE=1 SV=1" "0.000" "False" "31.491" "27" "6" "9" "6" "274" "30.7" "6.02" "37.42" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00248" "2730" "ENSG00000023909" "GCLM" "A8K334; D3DT45; hsa:2730; M5A959; P48507; Q6FHC1; Q9NPX9; Q9NU74" "Glutathione metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Amino acid metabolism; One-carbon metabolism and related pathways; Ferroptosis; NRF2-ARE regulation; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Glutathione synthesis and recycling; NFE2L2 regulating anti-oxidant/detoxification enzymes; Defective GCLC causes HAGGSD" "15" "0" "0.975" "0.984" "0.967" "1.054" "0.931" "1.073" "0.985" "0.979" "1.055" "1185.1" "1154.9" "1166.6" "1145.7" "1249.3" "1102.8" "1271.1" "1167.2" "1160.5" "1249.7" "" "" "" "" "" "" "" "" "" "" "1065.5" "934.5" "1055.2" "1118.4" "1030.9" "1102.8" "951.8" "1031.0" "1038.4" "446.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5974155710491899055" "False" "High" "IsMasterProtein" "Q9UHD2" "Serine/threonine-protein kinase TBK1 OS=Homo sapiens OX=9606 GN=TBK1 PE=1 SV=1" "0.000" "False" "31.436" "16" "11" "11" "11" "729" "83.6" "6.79" "36.16" "11" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf18394, Pf18396" "29110" "ENSG00000183735" "TBK1" "A8K4S4; hsa:29110; Q8IYV3; Q9NUJ5; Q9UHD2" "TNF-alpha signaling pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Toll-like receptor signaling pathway" "Negative regulators of DDX58/IFIH1 signaling; IRF3-mediated induction of type I IFN; Potential therapeutics for SARS; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Regulation of TNFR1 signaling; TICAM1-dependent activation of IRF3/IRF7; SARS-CoV-1 activates/modulates innate immune responses; TNFR1-induced proapoptotic signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Interleukin-37 signaling; Regulation of innate immune responses to cytosolic DNA; STAT6-mediated induction of chemokines; IRF3 mediated activation of type 1 IFN" "35" "0" "1.136" "1.183" "0.991" "1.167" "1.148" "1.163" "1.063" "1.118" "1.720" "728.1" "827.2" "861.6" "721.6" "849.9" "835.9" "847.0" "774.0" "813.8" "1252.6" "" "" "" "" "" "" "" "" "" "" "654.7" "669.4" "779.3" "704.4" "701.3" "835.9" "634.2" "683.7" "728.2" "447.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1371524125527115551" "False" "High" "IsMasterProtein" "Q9NZM3" "Intersectin-2 OS=Homo sapiens OX=9606 GN=ITSN2 PE=1 SV=3" "0.000" "False" "31.383" "7" "11" "11" "11" "1697" "193.3" "8.12" "36.21" "11" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00168, Pf00621, Pf07653, Pf12763, Pf14604, Pf16652" "50618" "ENSG00000198399" "ITSN2" "O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9NZM3; Q9ULG4" "" "Cargo recognition for clathrin-mediated endocytosis; RHOU GTPase cycle" "3" "0" "0.944" "0.920" "0.982" "1.019" "0.998" "1.098" "0.890" "0.950" "5.248" "730.9" "690.0" "672.8" "717.7" "744.8" "729.4" "802.6" "650.2" "694.4" "3836.0" "" "" "" "" "" "" "" "" "" "" "657.2" "558.3" "608.6" "700.5" "614.6" "729.4" "600.9" "574.3" "621.3" "1369.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "784332711560809760" "False" "High" "IsMasterProtein" "P62072" "Mitochondrial import inner membrane translocase subunit Tim10 OS=Homo sapiens OX=9606 GN=TIMM10 PE=1 SV=1" "0.000" "False" "31.373" "53" "5" "13" "5" "90" "10.3" "6.29" "44.51" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26519" "ENSG00000134809" "TIMM10" "A8K136; hsa:26519; P62072; Q9WV99; Q9WVA0; Q9Y5J8" "" "Mitochondrial protein degradation; Mitochondrial protein import" "2" "0" "1.014" "1.069" "0.946" "1.148" "1.076" "1.088" "1.115" "1.062" "0.888" "766.4" "777.5" "819.7" "725.3" "879.6" "824.5" "833.9" "854.4" "814.2" "680.5" "" "" "" "" "" "" "" "" "" "" "689.1" "629.1" "741.4" "708.0" "725.9" "824.5" "624.4" "754.7" "728.5" "242.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3626479859969264661" "False" "High" "IsMasterProtein" "Q96QG7" "Myotubularin-related protein 9 OS=Homo sapiens OX=9606 GN=MTMR9 PE=1 SV=1" "0.000" "False" "31.371" "18" "9" "11" "9" "549" "63.4" "6.39" "35.00" "9" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf06602, Pf21098" "66036" "ENSG00000104643; ENSG00000285032" "MTMR9" "B7Z291; hsa:66036; Q52LU3; Q8WW11; Q96QG6; Q96QG7; Q9NX50" "8p23.1 copy number variation syndrome" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of IP2, IP, and Ins in the cytosol" "4" "0" "1.081" "1.088" "0.992" "1.064" "1.058" "1.047" "1.063" "1.053" "0.802" "503.0" "543.9" "547.0" "498.9" "535.4" "532.0" "526.8" "534.7" "529.8" "403.4" "" "" "" "" "" "" "" "" "" "" "452.2" "440.1" "494.8" "487.0" "441.8" "532.0" "394.4" "472.2" "474.1" "144.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208996323542288612" "False" "High" "IsMasterProtein" "Q8N5P1" "Zinc finger CCCH domain-containing protein 8 OS=Homo sapiens OX=9606 GN=ZC3H8 PE=1 SV=2" "0.000" "False" "31.362" "35" "8" "10" "8" "291" "33.6" "8.28" "33.34" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608, Pf18345" "84524" "ENSG00000144161" "ZC3H8" "hsa:84524; Q8N5P1; Q9BZ75" "2q13 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.002" "1.038" "0.970" "0.987" "1.113" "0.964" "1.052" "1.010" "0.777" "786.8" "788.0" "816.3" "762.8" "776.5" "875.4" "758.1" "827.7" "794.2" "611.4" "" "" "" "" "" "" "" "" "" "" "707.4" "637.6" "738.4" "744.6" "640.8" "875.4" "567.7" "731.1" "710.7" "218.2" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2858860997982508935" "False" "High" "IsMasterProtein" "Q99757" "Thioredoxin, mitochondrial OS=Homo sapiens OX=9606 GN=TXN2 PE=1 SV=2" "0.000" "False" "31.357" "44" "4" "12" "4" "166" "18.4" "8.29" "57.22" "4" "stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00085" "25828" "ENSG00000100348" "TXN2" "hsa:25828; Q5JZA0; Q6FH60; Q99757; Q9UH29" "Oxidative stress response" "Detoxification of Reactive Oxygen Species; Degradation of cysteine and homocysteine" "3" "0" "0.938" "1.002" "0.962" "1.083" "1.020" "1.011" "1.108" "1.080" "0.837" "1042.6" "978.2" "1044.5" "1002.5" "1129.4" "1063.3" "1054.1" "1155.3" "1126.4" "872.7" "" "" "" "" "" "" "" "" "" "" "937.4" "791.5" "944.8" "978.6" "932.0" "1063.3" "789.3" "1020.4" "1007.9" "311.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5188184621199488866" "False" "High" "IsMasterProtein" "Q9GZT3" "SRA stem-loop-interacting RNA-binding protein, mitochondrial OS=Homo sapiens OX=9606 GN=SLIRP PE=1 SV=1" "0.000" "False" "31.303" "57" "7" "11" "7" "109" "12.3" "10.24" "43.86" "7" "other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf00076" "81892" "ENSG00000119705" "SLIRP" "hsa:81892; J3KMY7; Q9GZT3" "" "Mitochondrial RNA degradation" "1" "0" "1.075" "0.966" "0.955" "0.997" "0.961" "0.988" "1.074" "0.972" "2.447" "1258.9" "1353.0" "1215.8" "1202.0" "1255.6" "1210.4" "1244.1" "1352.4" "1223.1" "3080.7" "" "" "" "" "" "" "" "" "" "" "1131.9" "1094.8" "1099.8" "1173.3" "1036.2" "1210.4" "931.5" "1194.6" "1094.4" "1099.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1529174177095472519" "False" "High" "IsMasterProtein" "O14777" "Kinetochore protein NDC80 homolog OS=Homo sapiens OX=9606 GN=NDC80 PE=1 SV=1" "0.000" "False" "31.264" "13" "9" "10" "9" "642" "73.9" "5.60" "34.75" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03801, Pf18077" "10403" "ENSG00000080986" "NDC80" "hsa:10403; O14777; Q6PJX2" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.970" "1.044" "0.913" "0.943" "0.966" "0.926" "0.884" "1.039" "5.663" "1044.1" "1012.7" "1089.7" "953.0" "984.8" "1009.0" "966.3" "922.9" "1084.5" "5912.5" "" "" "" "" "" "" "" "" "" "" "938.7" "819.4" "985.7" "930.2" "812.6" "1009.0" "723.6" "815.2" "970.4" "2110.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2283979429673317137" "False" "High" "IsMasterProtein" "A6NIH7" "Protein unc-119 homolog B OS=Homo sapiens OX=9606 GN=UNC119B PE=1 SV=1" "0.000" "False" "31.251" "43" "8" "12" "8" "251" "28.1" "5.68" "44.09" "8" "cell organization and biogenesis;transport;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05351" "84747" "ENSG00000175970" "UNC119B" "A6NIH7; hsa:84747" "" "Trafficking of myristoylated proteins to the cilium" "1" "0" "0.965" "1.067" "1.020" "1.027" "1.011" "0.909" "0.969" "1.007" "1.097" "895.0" "863.4" "955.0" "913.2" "919.4" "904.9" "813.1" "867.3" "901.2" "982.2" "" "" "" "" "" "" "" "" "" "" "804.7" "698.6" "863.8" "891.4" "758.7" "904.9" "608.9" "766.1" "806.4" "350.6" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4679234799158284053" "False" "High" "IsMasterProtein" "Q8N954" "G patch domain-containing protein 11 OS=Homo sapiens OX=9606 GN=GPATCH11 PE=1 SV=4" "0.000" "False" "31.233" "36" "10" "13" "10" "285" "33.3" "5.86" "36.07" "10" "" "other cell component" "nucleic acid binding activity" "Pf01585, Pf13821" "253635" "" "GPATCH11" "A0A0A0MSF9; A8K0D9; B7Z2G4; B8ZZ44; hsa:253635; Q8N954" "" "" "0" "0" "0.885" "0.888" "0.984" "0.916" "0.928" "0.972" "1.010" "0.927" "0.722" "1025.1" "907.4" "910.5" "1008.6" "938.6" "950.8" "996.0" "1035.1" "950.6" "740.1" "" "" "" "" "" "" "" "" "" "" "921.7" "734.2" "823.5" "984.6" "774.6" "950.8" "745.8" "914.3" "850.6" "264.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1607467674154274672" "False" "High" "IsMasterProtein" "Q8N4Q1" "Mitochondrial intermembrane space import and assembly protein 40 OS=Homo sapiens OX=9606 GN=CHCHD4 PE=1 SV=1" "0.000" "False" "31.189" "47" "6" "14" "6" "142" "16.0" "4.31" "52.41" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "mitochondrion" "other molecular function" "Pf06747" "131474" "ENSG00000163528" "CHCHD4" "A8K3Z9; hsa:131474; Q8N4Q1; Q96AI2; Q96MY6" "" "Mitochondrial protein import" "1" "0" "0.924" "1.052" "0.975" "0.997" "1.076" "1.004" "1.131" "1.049" "0.708" "739.1" "683.1" "777.2" "720.7" "736.7" "795.5" "742.1" "835.5" "775.6" "523.0" "" "" "" "" "" "" "" "" "" "" "664.5" "552.7" "703.0" "703.5" "607.9" "795.5" "555.6" "738.0" "694.0" "186.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043384267201458756" "False" "High" "IsMasterProtein" "Q8TBX8" "Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma OS=Homo sapiens OX=9606 GN=PIP4K2C PE=1 SV=3" "0.000" "False" "31.166" "22" "10" "10" "10" "421" "47.3" "6.84" "36.28" "10" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf01504" "79837" "ENSG00000166908" "PIP4K2C" "B2RDL3; B4DM11; B4DY44; hsa:79837; Q8TBX8; Q9H6N2" "Regulation of actin cytoskeleton" "Synthesis of PIPs at the plasma membrane; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; PI5P Regulates TP53 Acetylation; Synthesis of PIPs in the nucleus" "5" "0" "1.170" "1.156" "1.058" "1.197" "1.185" "1.100" "1.128" "1.236" "1.306" "553.4" "647.6" "639.9" "585.5" "662.7" "655.6" "608.6" "624.1" "683.8" "722.6" "" "" "" "" "" "" "" "" "" "" "497.6" "524.0" "578.8" "571.6" "546.9" "655.6" "455.7" "551.3" "611.9" "257.9" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1178215793923997367" "False" "High" "IsMasterProtein" "Q96DM3" "Regulator of MON1-CCZ1 complex OS=Homo sapiens OX=9606 GN=RMC1 PE=1 SV=2" "0.000" "False" "31.163" "13" "7" "12" "7" "657" "74.9" "7.83" "45.25" "7" "other metabolic processes;other biological processes" "other membranes;other cytoplasmic organelle" "" "Pf07035, Pf21029" "29919" "ENSG00000141452" "RMC1" "Q96DM3; Q9BU17; Q9Y5M0" "" "" "0" "0" "1.032" "0.999" "0.982" "1.001" "0.938" "1.031" "0.987" "0.985" "0.900" "1071.9" "1106.3" "1071.3" "1053.1" "1072.9" "1005.6" "1105.0" "1057.8" "1055.8" "964.3" "" "" "" "" "" "" "" "" "" "" "963.8" "895.2" "969.0" "1028.0" "885.4" "1005.6" "827.4" "934.3" "944.8" "344.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1837878793854205649" "False" "High" "IsMasterProtein" "Q9BVL2" "Nucleoporin p58/p45 OS=Homo sapiens OX=9606 GN=NUP58 PE=1 SV=1" "0.000" "False" "31.160" "15" "9" "14" "9" "599" "60.9" "9.33" "45.41" "9" "transport;other biological processes" "other membranes;nucleus" "other molecular function" "Pf15967" "9818" "ENSG00000139496" "NUP58" "A6NI12; B4DZJ1; hsa:9818; O43160; Q5JRG2; Q5JRG5; Q9BVL2" "" "" "0" "0" "1.084" "1.029" "0.991" "1.056" "0.985" "1.057" "1.035" "1.024" "1.091" "633.8" "686.8" "651.9" "628.3" "669.0" "624.4" "670.0" "656.1" "648.7" "691.5" "" "" "" "" "" "" "" "" "" "" "569.8" "555.7" "589.7" "613.3" "552.1" "624.4" "501.7" "579.5" "580.5" "246.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-81494833362564834" "False" "High" "IsMasterProtein" "Q8WVJ2" "NudC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NUDCD2 PE=1 SV=1" "0.000" "False" "31.139" "41" "5" "10" "5" "157" "17.7" "5.07" "45.26" "5" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf04969" "134492" "ENSG00000170584" "NUDCD2" "B2R4V0; hsa:134492; Q8WVJ2" "" "" "0" "0" "0.954" "0.947" "0.969" "1.006" "0.940" "1.064" "0.953" "0.924" "1.880" "818.3" "780.8" "774.6" "793.3" "823.3" "769.1" "870.3" "780.0" "755.8" "1538.4" "" "" "" "" "" "" "" "" "" "" "735.8" "631.8" "700.6" "774.4" "679.4" "769.1" "651.7" "688.9" "676.3" "549.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569062232649936506" "False" "High" "IsMasterProtein" "Q9NVH2" "Integrator complex subunit 7 OS=Homo sapiens OX=9606 GN=INTS7 PE=1 SV=1" "0.000" "False" "31.110" "10" "9" "10" "9" "962" "106.8" "8.02" "34.11" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "" "25896" "ENSG00000143493" "INTS7" "B4DLZ6; B7WNP6; B7WPB6; hsa:25896; Q8N4K7; Q8WUH5; Q9H9V3; Q9NVH2; Q9NVU5; Q9UFC6; Q9UFM3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.093" "1.080" "0.948" "1.022" "1.074" "1.070" "0.996" "1.024" "1.301" "637.7" "697.0" "688.9" "604.3" "651.6" "684.6" "682.4" "635.1" "652.8" "829.7" "" "" "" "" "" "" "" "" "" "" "573.4" "564.0" "623.1" "589.9" "537.7" "684.6" "511.0" "561.0" "584.1" "296.2" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-200305812606160804" "False" "High" "IsMasterProtein" "Q3MHD2" "Protein LSM12 OS=Homo sapiens OX=9606 GN=LSM12 PE=1 SV=2" "0.000" "False" "31.084" "33" "5" "14" "5" "195" "21.7" "7.74" "54.93" "5" "" "other cell component" "nucleic acid binding activity" "Pf09793, Pf21166" "124801" "ENSG00000161654" "LSM12" "hsa:124801; Q3MHD2; Q86YB1; Q96NL5" "" "" "0" "0" "1.046" "1.062" "1.087" "1.083" "0.882" "1.003" "1.151" "1.037" "0.970" "675.0" "706.1" "717.2" "733.5" "730.8" "595.6" "677.1" "776.7" "700.3" "654.5" "" "" "" "" "" "" "" "" "" "" "606.9" "571.4" "648.7" "716.0" "603.0" "595.6" "507.0" "686.0" "626.6" "233.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6764282473727919069" "False" "High" "IsMasterProtein" "Q96K17" "Transcription factor BTF3 homolog 4 OS=Homo sapiens OX=9606 GN=BTF3L4 PE=1 SV=1" "0.000" "False" "31.066" "44" "6" "13" "4" "158" "17.3" "6.35" "54.96" "6" "" "" "" "Pf01849" "91408" "ENSG00000134717" "BTF3L4" "B3KNJ1; D3DQ32; G3V1C6; hsa:91408; Q96K17" "" "" "0" "0" "0.898" "0.958" "0.950" "1.079" "0.998" "1.000" "1.034" "1.003" "0.877" "1151.8" "1034.0" "1103.3" "1094.0" "1242.8" "1149.1" "1151.9" "1191.0" "1155.7" "1010.5" "" "" "" "" "" "" "" "" "" "" "1035.6" "836.7" "998.0" "1067.9" "1025.6" "1149.1" "862.5" "1051.9" "1034.1" "360.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477032751293866758" "False" "High" "IsMasterProtein" "Q96MF7" "E3 SUMO-protein ligase NSE2 OS=Homo sapiens OX=9606 GN=NSMCE2 PE=1 SV=2" "0.000" "False" "31.049" "39" "8" "11" "8" "247" "27.9" "7.74" "38.79" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11789" "286053" "ENSG00000156831" "NSMCE2" "hsa:286053; Q8N549; Q96MF7" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.909" "0.951" "0.854" "0.912" "0.981" "0.862" "0.946" "0.966" "0.798" "1065.0" "967.9" "1012.7" "909.1" "971.3" "1044.3" "918.1" "1007.2" "1028.9" "849.6" "" "" "" "" "" "" "" "" "" "" "957.6" "783.2" "916.0" "887.4" "801.5" "1044.3" "687.4" "889.6" "920.6" "303.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2556880978610824670" "False" "High" "IsMasterProtein" "P62256" "Ubiquitin-conjugating enzyme E2 H OS=Homo sapiens OX=9606 GN=UBE2H PE=1 SV=1" "0.000" "False" "31.044" "35" "6" "9" "6" "183" "20.6" "4.67" "38.22" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "7328" "ENSG00000186591" "UBE2H" "A4D1L6; C9JY93; hsa:7328; P37286; P62256; Q7Z6F4" "Ciliary landscape" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "1.104" "1.124" "1.091" "1.072" "1.272" "1.015" "1.046" "1.154" "0.919" "1108.3" "1224.1" "1245.2" "1208.7" "1188.4" "1409.5" "1125.0" "1159.4" "1278.5" "1018.4" "" "" "" "" "" "" "" "" "" "" "996.5" "990.5" "1126.4" "1179.9" "980.7" "1409.5" "842.4" "1024.1" "1144.0" "363.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345660777743534482" "False" "High" "IsMasterProtein" "Q9NPJ6" "Mediator of RNA polymerase II transcription subunit 4 OS=Homo sapiens OX=9606 GN=MED4 PE=1 SV=1" "0.000" "False" "31.002" "34" "8" "10" "8" "270" "29.7" "5.10" "41.12" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10018" "29079" "ENSG00000136146" "MED4" "B4DX67; hsa:29079; Q53GB4; Q53H68; Q5T912; Q6FHC4; Q6IA79; Q9BS95; Q9NPJ6; Q9NYR5" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.987" "1.019" "0.981" "0.954" "1.066" "1.013" "1.032" "1.061" "1.066" "710.8" "701.3" "724.3" "697.5" "678.2" "757.4" "719.8" "733.3" "754.3" "757.6" "" "" "" "" "" "" "" "" "" "" "639.0" "567.5" "655.2" "680.8" "559.7" "757.4" "539.0" "647.7" "674.9" "270.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278234146555232268" "False" "High" "IsMasterProtein" "Q96BK5" "PIN2/TERF1-interacting telomerase inhibitor 1 OS=Homo sapiens OX=9606 GN=PINX1 PE=1 SV=2" "0.000" "False" "30.981" "30" "8" "10" "8" "328" "37.0" "9.60" "36.31" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01585" "54984" "ENSG00000254093; ENSG00000284764" "PINX1" "B2R9B1; hsa:54984; Q548A5; Q6QWG9; Q7Z7J8; Q96BK5; Q96QD7; Q9HBU7; Q9NWW2" "" "" "0" "0" "0.926" "1.024" "0.892" "0.946" "1.298" "0.958" "0.915" "0.988" "0.772" "1006.3" "932.2" "1030.1" "897.4" "952.2" "1305.7" "964.5" "920.6" "994.3" "776.7" "" "" "" "" "" "" "" "" "" "" "904.7" "754.3" "931.8" "876.0" "785.8" "1305.7" "722.2" "813.2" "889.7" "277.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2760060553440129895" "False" "High" "IsMasterProtein" "Q8NDB2" "B-cell scaffold protein with ankyrin repeats OS=Homo sapiens OX=9606 GN=BANK1 PE=1 SV=3" "0.000" "False" "30.974" "15" "9" "10" "9" "785" "89.2" "5.40" "34.16" "9" "signal transduction;other biological processes" "other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf14545, Pf18567" "55024" "ENSG00000153064" "BANK1" "A8K7W8; B0F3S2; hsa:55024; Q8N5K8; Q8NB56; Q8NDB2; Q8WYN5; Q9NWP2" "" "" "0" "0" "1.082" "1.068" "1.061" "1.082" "1.043" "1.100" "1.052" "1.046" "1.165" "547.9" "592.7" "584.9" "581.2" "592.8" "571.5" "603.0" "576.5" "573.4" "638.1" "" "" "" "" "" "" "" "" "" "" "492.6" "479.6" "529.1" "567.3" "489.2" "571.5" "451.5" "509.2" "513.0" "227.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4149430532130191750" "False" "High" "IsMasterProtein" "Q13057" "Bifunctional coenzyme A synthase OS=Homo sapiens OX=9606 GN=COASY PE=1 SV=4" "0.000" "False" "30.968" "17" "8" "11" "8" "564" "62.3" "6.99" "39.37" "8" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf01121, Pf01467" "80347" "ENSG00000068120" "COASY" "B2RA78; B4DLU0; hsa:80347; Q13057; Q6GS23; Q8NBM7; Q8NEW1; Q8WXD4; Q9NRM3" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway" "Coenzyme A biosynthesis" "2" "0" "1.139" "1.154" "0.965" "1.123" "1.179" "1.058" "1.119" "1.322" "1.098" "427.2" "486.4" "493.1" "412.3" "479.9" "503.5" "452.0" "478.2" "564.8" "469.0" "" "" "" "" "" "" "" "" "" "" "384.1" "393.6" "446.0" "402.5" "396.0" "503.5" "338.5" "422.4" "505.4" "167.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5840066189523461680" "False" "High" "IsMasterProtein" "P22694" "cAMP-dependent protein kinase catalytic subunit beta OS=Homo sapiens OX=9606 GN=PRKACB PE=1 SV=2" "0.000" "False" "30.930" "26" "8" "13" "1" "351" "40.6" "8.78" "46.72" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5567" "ENSG00000142875" "PRKACB" "B1APG4; B4DKB0; B4E2Q1; hsa:5567; P22694; Q14VH1; Q59GC0; Q5BNE9; Q5BNF0; Q5BNF1; Q5BNF2; Q5BNF3; Q5CZ92; Q5T1K3; Q7Z3M1; Q8IYR5; Q8IZQ0; Q96B09" "AMP-activated protein kinase signaling; Dopamine metabolism; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; G protein signaling pathways; MAPK signaling pathway; Cannabinoid receptor signaling; Chemokine signaling pathway; Lipid metabolism pathway; Ras signaling; Hedgehog signaling pathway; Thermogenesis; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; GPR143 in melanocytes and retinal pigment epithelium cells; Vasopressin-regulated water reabsorption; Cardiomyocyte signaling pathways converging on titin; Calcium regulation in cardiac cells; ADHD and autism (ASD) linked metabolic pathways and SNP; EPAC1 and PKA reduction of retinal inflammation; Sudden infant death syndrome (SIDS) susceptibility pathways" "FCGR3A-mediated IL10 synthesis; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; MAPK6/MAPK4 signaling; Triglyceride catabolism; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; RET signaling; VEGFA-VEGFR2 Pathway; Factors involved in megakaryocyte development and platelet production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Regulation of glycolysis by fructose 2,6-bisphosphate metabolism; CD209 (DC-SIGN) signaling; Rap1 signalling; HDL assembly; DARPP-32 events; CREB1 phosphorylation through the activation of Adenylate Cyclase; ROBO receptors bind AKAP5; PKA-mediated phosphorylation of key metabolic factors" "47" "0" "1.017" "1.037" "0.991" "1.259" "0.889" "1.038" "1.257" "0.934" "2.283" "146.9" "149.4" "152.4" "145.6" "184.9" "130.6" "152.5" "184.6" "137.1" "335.2" "" "" "" "" "" "" "" "" "" "" "132.1" "120.9" "137.8" "142.1" "152.6" "130.6" "114.2" "163.0" "122.7" "119.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3369137616140023088" "False" "High" "IsMasterProtein" "Q9NZJ9" "Diphosphoinositol polyphosphate phosphohydrolase 2 OS=Homo sapiens OX=9606 GN=NUDT4 PE=1 SV=2" "0.000" "False" "30.920" "39" "6" "10" "4" "180" "20.3" "6.35" "33.15" "6" "other metabolic processes;signal transduction" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "11163" "ENSG00000173598" "NUDT4" "B7Z916; hsa:11163; Q4AEJ6; Q53EZ2; Q68DD7; Q9NPC5; Q9NS30; Q9NZJ9; Q9NZK0; Q9NZK1" "" "Synthesis of pyrophosphates in the cytosol" "1" "1" "0.941" "1.022" "0.963" "1.049" "0.995" "1.039" "0.964" "1.002" "1.119" "757.4" "712.7" "774.0" "729.6" "794.6" "753.3" "787.2" "730.0" "759.2" "847.3" "" "" "" "" "" "" "" "" "" "" "681.0" "576.7" "700.1" "712.1" "655.7" "753.3" "589.4" "644.8" "679.3" "302.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3527140061799616806" "False" "High" "IsMasterProtein" "Q9BW19" "Kinesin-like protein KIFC1 OS=Homo sapiens OX=9606 GN=KIFC1 PE=1 SV=2" "0.000" "False" "30.915" "17" "9" "10" "9" "673" "73.7" "8.98" "36.47" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cytoplasmic organelle" "cytoskeletal activity;other molecular function" "Pf00225" "3833" "ENSG00000204197; ENSG00000233450; ENSG00000237649" "KIFC1" "hsa:3833; O60887; Q14834; Q4KMP0; Q5SU09; Q6GMS7; Q6P4A5; Q9BW19; Q9UQP7" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "1.053" "1.103" "0.972" "1.102" "1.109" "1.047" "0.997" "1.109" "1.760" "351.9" "370.7" "388.1" "342.0" "387.9" "390.1" "368.5" "350.9" "390.1" "619.5" "" "" "" "" "" "" "" "" "" "" "316.4" "299.9" "351.0" "333.9" "320.1" "390.1" "276.0" "310.0" "349.1" "221.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700726988884900620" "False" "High" "IsMasterProtein" "Q9BQ61" "Telomerase RNA component interacting RNase OS=Homo sapiens OX=9606 GN=TRIR PE=1 SV=1" "0.000" "False" "30.909" "35" "5" "16" "5" "176" "18.4" "9.44" "63.67" "5" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "" "79002" "ENSG00000123144" "TRIR" "hsa:79002; Q9BQ61" "" "" "0" "0" "0.944" "0.977" "0.969" "0.950" "0.993" "0.937" "1.000" "0.964" "0.757" "2042.3" "1928.3" "1995.9" "1979.4" "1940.6" "2028.1" "1912.7" "2042.4" "1968.0" "1546.2" "" "" "" "" "" "" "" "" "" "" "1836.3" "1560.3" "1805.4" "1932.1" "1601.4" "2028.1" "1432.2" "1804.0" "1761.0" "551.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1587907933929237870" "False" "High" "IsMasterProtein" "Q02548" "Paired box protein Pax-5 OS=Homo sapiens OX=9606 GN=PAX5 PE=1 SV=1" "0.000" "False" "30.899" "24" "6" "9" "6" "391" "42.1" "9.00" "39.86" "6" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00292, Pf12403" "5079" "ENSG00000196092" "PAX5" "A3QVP6; A3QVP7; A3QVP8; C0KTF6; C0KTF7; C0KTF8; C0KTF9; C0KTG0; hsa:5079; O75933; Q02548; Q5SFM2; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732" "Prion disease pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2; ID signaling pathway" "RUNX1 regulates transcription of genes involved in BCR signaling" "4" "0" "1.022" "0.867" "1.013" "1.122" "0.963" "1.041" "1.068" "0.960" "1.027" "473.1" "483.5" "410.3" "479.3" "530.6" "455.7" "492.6" "505.2" "454.3" "485.9" "" "" "" "" "" "" "" "" "" "" "425.3" "391.2" "371.1" "467.9" "437.9" "455.7" "368.9" "446.2" "406.5" "173.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5145837311521029190" "False" "High" "IsMasterProtein" "Q8N183" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 OS=Homo sapiens OX=9606 GN=NDUFAF2 PE=1 SV=1" "0.000" "False" "30.898" "54" "8" "12" "8" "169" "19.8" "8.97" "48.44" "8" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf05071" "91942" "ENSG00000164182" "NDUFAF2" "A8K5I1; hsa:91942; Q8N183" "SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Complex I biogenesis" "2" "0" "1.004" "0.901" "1.033" "0.888" "0.933" "0.936" "1.001" "0.946" "0.656" "1012.3" "1016.1" "911.7" "1045.6" "898.5" "944.4" "947.9" "1012.9" "957.3" "664.0" "" "" "" "" "" "" "" "" "" "" "910.2" "822.2" "824.7" "1020.6" "741.5" "944.4" "709.8" "894.7" "856.6" "237.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4570011154676120481" "False" "High" "IsMasterProtein" "Q9NRF9" "DNA polymerase epsilon subunit 3 OS=Homo sapiens OX=9606 GN=POLE3 PE=1 SV=1" "0.000" "False" "30.896" "49" "8" "13" "8" "147" "16.8" "4.74" "41.43" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54107" "ENSG00000148229" "POLE3" "hsa:54107; Q5W0U1; Q8N758; Q8NCE5; Q9NR32; Q9NRF9" "Pyrimidine metabolism; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Activation of the pre-replicative complex; PCNA-Dependent Long Patch Base Excision Repair; DNA replication initiation" "16" "0" "0.923" "0.976" "1.006" "1.055" "0.932" "0.979" "1.097" "0.962" "1.054" "582.3" "537.2" "568.4" "585.8" "614.3" "542.5" "570.0" "638.9" "560.1" "613.9" "" "" "" "" "" "" "" "" "" "" "523.6" "434.7" "514.1" "571.9" "506.9" "542.5" "426.8" "564.4" "501.2" "219.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4314325281228425264" "False" "High" "IsMasterProtein" "O15382" "Branched-chain-amino-acid aminotransferase, mitochondrial OS=Homo sapiens OX=9606 GN=BCAT2 PE=1 SV=2" "0.000" "False" "30.884" "19" "6" "11" "6" "392" "44.3" "8.65" "47.37" "6" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf01063" "587" "ENSG00000105552" "BCAT2" "B2RB87; hsa:587; O00269; O15382; Q96KG1; Q9BTB6; Q9BUU6" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Branched-chain amino acid catabolism" "3" "0" "0.961" "1.068" "1.004" "1.199" "1.022" "0.972" "0.994" "1.133" "0.848" "612.9" "589.0" "654.7" "615.1" "734.5" "626.4" "595.7" "609.2" "694.3" "519.5" "" "" "" "" "" "" "" "" "" "" "551.0" "476.6" "592.2" "600.5" "606.2" "626.4" "446.0" "538.1" "621.3" "185.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8494127544242029271" "False" "High" "IsMasterProtein" "P62249" "Small ribosomal subunit protein uS9 OS=Homo sapiens OX=9606 GN=RPS16 PE=1 SV=2" "0.000" "False" "30.834" "60" "11" "16" "11" "146" "16.4" "10.21" "50.00" "11" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00380" "6217" "ENSG00000105193" "RPS16" "B2RDD5; hsa:6217; P17008; P62249" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; SARS-CoV-1 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "19" "0" "0.992" "0.991" "0.952" "0.921" "1.106" "0.966" "0.833" "1.036" "1.316" "1471.2" "1459.2" "1457.6" "1400.3" "1355.5" "1627.2" "1420.6" "1224.8" "1524.4" "1936.1" "" "" "" "" "" "" "" "" "" "" "1322.7" "1180.7" "1318.5" "1366.9" "1118.6" "1627.2" "1063.7" "1081.8" "1364.0" "691.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7697340015663074004" "False" "High" "IsMasterProtein" "P56211" "cAMP-regulated phosphoprotein 19 OS=Homo sapiens OX=9606 GN=ARPP19 PE=1 SV=2" "0.000" "False" "30.770" "40" "4" "12" "3" "112" "12.3" "9.09" "36.59" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf04667" "10776" "ENSG00000128989" "ARPP19" "B2R497; hsa:10776; P56211; Q6IAM2; Q86TA6; Q9UD70" "" "MASTL Facilitates Mitotic Progression" "1" "0" "0.948" "0.882" "0.946" "0.885" "1.038" "0.944" "0.995" "0.938" "0.753" "611.2" "579.6" "538.8" "578.5" "540.9" "634.5" "576.9" "608.1" "573.4" "460.2" "" "" "" "" "" "" "" "" "" "" "549.6" "469.0" "487.4" "564.7" "446.3" "634.5" "431.9" "537.1" "513.1" "164.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7153575726197497326" "False" "High" "IsMasterProtein" "Q7Z6B0" "Coiled-coil domain-containing protein 91 OS=Homo sapiens OX=9606 GN=CCDC91 PE=1 SV=2" "0.000" "False" "30.748" "22" "10" "10" "10" "441" "49.9" "5.07" "33.92" "10" "transport" "other membranes;cytosol;ER/Golgi;nucleus" "" "" "55297" "ENSG00000123106" "CCDC91" "B3KSA3; C9JR07; hsa:55297; Q68D43; Q6IA78; Q7Z6B0; Q8NEN7; Q9NUW9" "" "" "0" "0" "0.977" "0.971" "0.969" "0.980" "0.952" "1.029" "1.004" "1.003" "0.919" "1509.5" "1475.2" "1465.4" "1462.4" "1479.4" "1436.4" "1553.4" "1516.0" "1514.2" "1386.6" "" "" "" "" "" "" "" "" "" "" "1357.2" "1193.7" "1325.5" "1427.5" "1220.8" "1436.4" "1163.2" "1339.0" "1354.9" "495.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3918971924664803467" "False" "High" "IsMasterProtein" "Q14088" "Ras-related protein Rab-33A OS=Homo sapiens OX=9606 GN=RAB33A PE=1 SV=2" "0.000" "False" "30.746" "41" "9" "11" "9" "237" "26.6" "7.88" "38.82" "9" "signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "9363" "ENSG00000134594" "RAB33A" "hsa:9363; Q14088; Q5JUZ6; Q92465" "" "RAB geranylgeranylation; TBC/RABGAPs" "2" "0" "1.027" "1.052" "0.974" "1.053" "1.007" "1.052" "1.014" "1.040" "0.903" "1221.7" "1255.1" "1285.3" "1190.1" "1286.5" "1229.9" "1285.3" "1238.5" "1270.7" "1102.9" "" "" "" "" "" "" "" "" "" "" "1098.5" "1015.6" "1162.6" "1161.7" "1061.7" "1229.9" "962.4" "1093.9" "1137.0" "393.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6333223318553199487" "False" "High" "IsMasterProtein" "Q14919" "Dr1-associated corepressor OS=Homo sapiens OX=9606 GN=DRAP1 PE=1 SV=3" "0.000" "False" "30.728" "31" "5" "13" "5" "205" "22.3" "5.17" "46.40" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00808" "10589" "ENSG00000175550" "DRAP1" "hsa:10589; Q13448; Q14919" "" "Signaling by NODAL; Signaling by Activin" "2" "0" "0.956" "1.098" "1.030" "1.072" "1.100" "1.113" "1.041" "1.160" "1.017" "911.4" "871.0" "1000.8" "938.7" "976.9" "1002.5" "1014.3" "948.7" "1057.0" "926.7" "" "" "" "" "" "" "" "" "" "" "819.4" "704.8" "905.2" "916.3" "806.2" "1002.5" "759.5" "838.0" "945.8" "330.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3185905528720532686" "False" "High" "IsMasterProtein" "P01903" "HLA class II histocompatibility antigen, DR alpha chain OS=Homo sapiens OX=9606 GN=HLA-DRA PE=1 SV=2" "0.000" "False" "30.728" "26" "5" "12" "4" "254" "28.6" "5.00" "51.29" "5" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00993, Pf07654" "3122" "ENSG00000204287; ENSG00000206308; ENSG00000226260; ENSG00000227993; ENSG00000228987; ENSG00000230726; ENSG00000234794; ENSG00000277263" "HLA-DRA" "A2BET4; hsa:3122; P01903; Q30160; Q6IAZ1; Q861I2; Q9TP70" "Allograft rejection; PI3K/AKT/mTOR - vitamin D3 signaling; Ebola virus infection in host; Male infertility; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; 11p11.2 copy number variation syndrome" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "16" "0" "0.932" "0.874" "1.041" "0.988" "0.855" "1.052" "0.971" "0.998" "0.787" "1011.0" "941.9" "883.1" "1052.8" "998.4" "864.8" "1063.8" "981.7" "1009.2" "795.6" "" "" "" "" "" "" "" "" "" "" "909.0" "762.1" "798.8" "1027.6" "823.9" "864.8" "796.5" "867.1" "903.1" "284.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5836561258245124912" "False" "High" "IsMasterProtein" "Q6P6C2" "RNA demethylase ALKBH5 OS=Homo sapiens OX=9606 GN=ALKBH5 PE=1 SV=2" "0.000" "False" "30.705" "18" "6" "9" "6" "394" "44.2" "9.09" "37.73" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf13532" "54890" "ENSG00000091542" "ALKBH5" "B4DVJ4; D3DXC6; hsa:54890; Q6P6C2; Q9NXD6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Reversal of alkylation damage by DNA dioxygenases" "2" "0" "0.940" "0.985" "0.982" "1.028" "0.952" "0.959" "0.916" "0.906" "1.302" "720.3" "676.8" "709.7" "707.0" "740.4" "685.9" "690.4" "659.7" "652.3" "937.5" "" "" "" "" "" "" "" "" "" "" "647.6" "547.6" "641.9" "690.2" "611.0" "685.9" "517.0" "582.7" "583.7" "334.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5470294891726501754" "False" "High" "IsMasterProtein" "P61962" "DDB1- and CUL4-associated factor 7 OS=Homo sapiens OX=9606 GN=DCAF7 PE=1 SV=1" "0.000" "False" "30.657" "26" "8" "9" "8" "342" "38.9" "5.52" "33.68" "8" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400" "10238" "ENSG00000136485" "DCAF7" "B4E039; D3DU14; hsa:10238; O15491; P61962; Q9DAE4" "Ciliary landscape; DYRK1A involvement regarding cell proliferation in brain development" "Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "4" "0" "1.066" "1.037" "1.051" "1.134" "1.047" "1.178" "1.001" "0.971" "1.009" "448.6" "478.2" "465.4" "471.4" "508.9" "469.7" "528.6" "448.9" "435.7" "452.5" "" "" "" "" "" "" "" "" "" "" "403.3" "386.9" "420.9" "460.1" "419.9" "469.7" "395.8" "396.5" "389.9" "161.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1684474116770674977" "False" "High" "IsMasterProtein" "Q9NW68" "BSD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BSDC1 PE=1 SV=1" "0.000" "False" "30.600" "22" "7" "9" "7" "430" "47.1" "4.49" "31.73" "7" "" "other cell component" "" "Pf03909" "55108" "ENSG00000160058" "BSDC1" "B4DMS7; B4DTI7; B4DTP7; B4E2X8; hsa:55108; Q49AT8; Q68DY6; Q6IAA3; Q6MZK1; Q6UXS1; Q9HAL9; Q9NW68" "" "" "0" "0" "0.942" "0.922" "0.885" "1.004" "1.004" "0.909" "0.908" "0.945" "0.928" "474.4" "446.8" "437.1" "419.9" "476.2" "476.3" "431.2" "431.0" "448.4" "440.4" "" "" "" "" "" "" "" "" "" "" "426.5" "361.6" "395.4" "409.9" "392.9" "476.3" "322.9" "380.6" "401.2" "157.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658757101665122516" "False" "High" "IsMasterProtein" "Q9ULP9" "TBC1 domain family member 24 OS=Homo sapiens OX=9606 GN=TBC1D24 PE=1 SV=2" "0.000" "False" "30.600" "15" "8" "10" "8" "559" "62.9" "7.36" "36.29" "8" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf00566, Pf07534" "57465" "ENSG00000162065" "TBC1D24" "A0JNW3; B9A6M6; hsa:57465; Q2KJ08; Q9ULP9" "" "TBC/RABGAPs" "1" "0" "1.005" "0.989" "0.942" "0.992" "0.974" "0.952" "0.936" "0.983" "0.999" "610.7" "613.5" "603.8" "575.4" "605.5" "595.1" "581.7" "571.4" "600.1" "609.8" "" "" "" "" "" "" "" "" "" "" "549.1" "496.4" "546.2" "561.7" "499.7" "595.1" "435.6" "504.7" "537.0" "217.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4174205388023222362" "False" "High" "IsMasterProtein" "Q96H20" "Vacuolar-sorting protein SNF8 OS=Homo sapiens OX=9606 GN=SNF8 PE=1 SV=1" "0.000" "False" "30.600" "28" "6" "8" "6" "258" "28.8" "6.65" "35.02" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04157" "11267" "ENSG00000159210" "SNF8" "hsa:11267; Q8IXY3; Q96H20; Q9UN50" "" "Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events" "2" "0" "1.002" "1.024" "0.957" "1.032" "1.041" "1.092" "1.079" "1.045" "0.899" "1092.4" "1094.3" "1118.3" "1046.0" "1127.1" "1137.5" "1193.0" "1178.8" "1141.2" "982.6" "" "" "" "" "" "" "" "" "" "" "982.2" "885.5" "1011.5" "1021.0" "930.1" "1137.5" "893.3" "1041.2" "1021.1" "350.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9041443353459398324" "False" "High" "IsMasterProtein" "Q8N9N7" "Leucine-rich repeat-containing protein 57 OS=Homo sapiens OX=9606 GN=LRRC57 PE=1 SV=1" "0.000" "False" "30.596" "26" "6" "10" "6" "239" "26.7" "8.43" "32.58" "6" "" "other membranes" "" "Pf13855" "255252" "ENSG00000180979" "LRRC57" "hsa:255252; Q7Z2Z6; Q8N1T6; Q8N9N7" "" "" "0" "0" "1.003" "1.041" "0.980" "1.014" "1.006" "1.011" "0.998" "1.098" "0.898" "538.4" "540.1" "560.6" "527.7" "546.0" "541.7" "544.0" "537.5" "591.3" "483.5" "" "" "" "" "" "" "" "" "" "" "484.0" "437.0" "507.1" "515.1" "450.6" "541.7" "407.3" "474.7" "529.1" "172.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4704340040215325088" "False" "High" "IsMasterProtein" "Q9GZN8" "Adipose-secreted signaling protein OS=Homo sapiens OX=9606 GN=ADISSP PE=1 SV=3" "0.000" "False" "30.590" "56" "7" "13" "7" "174" "19.3" "6.84" "48.74" "7" "other metabolic processes;other biological processes" "non-structural extracellular" "other molecular function" "Pf15006" "54976" "ENSG00000101220" "ADISSP" "A8K4J0; D3DVX8; hsa:54976; Q5JX81; Q9GZN8; Q9NWX3" "" "" "0" "0" "1.022" "0.930" "1.165" "1.053" "1.056" "1.103" "1.101" "1.066" "0.886" "664.3" "679.1" "617.6" "774.2" "699.8" "701.8" "732.6" "731.5" "708.2" "588.9" "" "" "" "" "" "" "" "" "" "" "597.3" "549.5" "558.7" "755.7" "577.5" "701.8" "548.5" "646.1" "633.7" "210.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163980209620091115" "False" "High" "IsMasterProtein" "O43598" "5-hydroxymethyl-dUMP N-hydrolase OS=Homo sapiens OX=9606 GN=DNPH1 PE=1 SV=1" "0.000" "False" "30.578" "53" "7" "16" "7" "174" "19.1" "5.05" "55.21" "7" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05014" "10591" "ENSG00000112667" "DNPH1" "B2LUJ9; hsa:10591; O43598" "" "Purine catabolism" "1" "0" "1.222" "1.155" "1.192" "1.227" "1.312" "1.271" "1.220" "1.395" "0.815" "596.3" "728.8" "688.7" "710.8" "731.8" "782.6" "757.9" "727.7" "831.8" "485.8" "" "" "" "" "" "" "" "" "" "" "536.1" "589.7" "622.9" "693.8" "603.9" "782.6" "567.5" "642.7" "744.2" "173.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8531201272546720497" "False" "High" "IsMasterProtein" "P14854" "Cytochrome c oxidase subunit 6B1 OS=Homo sapiens OX=9606 GN=COX6B1 PE=1 SV=2" "0.000" "False" "30.566" "74" "6" "13" "6" "86" "10.2" "7.05" "42.96" "6" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02297" "1340" "ENSG00000126267" "COX6B1" "B2R5C9; hsa:1340; P14854; Q6IBL4" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Cytoprotection by HMOX1; Respiratory electron transport; TP53 Regulates Metabolic Genes" "7" "0" "0.926" "1.077" "0.882" "0.901" "1.017" "0.898" "0.971" "0.948" "0.844" "1626.8" "1506.3" "1752.3" "1435.0" "1465.5" "1653.8" "1460.4" "1579.9" "1542.6" "1373.2" "" "" "" "" "" "" "" "" "" "" "1462.6" "1218.9" "1585.0" "1400.8" "1209.3" "1653.8" "1093.5" "1395.5" "1380.3" "490.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7337665348008384774" "False" "High" "IsMasterProtein" "O60701" "UDP-glucose 6-dehydrogenase OS=Homo sapiens OX=9606 GN=UGDH PE=1 SV=1" "0.000" "False" "30.543" "21" "8" "8" "8" "494" "55.0" "7.12" "31.09" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes" "cytosol;nucleus" "other molecular function" "Pf00984, Pf03720, Pf03721" "7358" "ENSG00000109814" "UGDH" "B3KUU2; B4DN25; hsa:7358; O60589; O60701" "UDP-derived sugars synthesis in fibroblasts; Glucuronidation" "Formation of the active cofactor, UDP-glucuronate" "3" "0" "0.998" "1.006" "0.949" "1.008" "1.060" "1.021" "1.033" "1.099" "1.140" "372.5" "371.6" "374.9" "353.7" "375.6" "394.9" "380.4" "384.6" "409.3" "424.6" "" "" "" "" "" "" "" "" "" "" "334.9" "300.7" "339.1" "345.2" "310.0" "394.9" "284.9" "339.7" "366.3" "151.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8786307772961790223" "False" "High" "IsMasterProtein" "Q6QNY1" "Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Homo sapiens OX=9606 GN=BLOC1S2 PE=1 SV=1" "0.000" "False" "30.486" "44" "6" "9" "6" "142" "16.0" "4.86" "39.89" "6" "cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf10046" "282991" "ENSG00000196072" "BLOC1S2" "B4DQV2; hsa:282991; Q5W040; Q6QNY1; Q8WUI8" "" "" "0" "0" "0.938" "0.956" "0.934" "1.006" "0.980" "0.996" "1.006" "0.979" "0.878" "1041.3" "976.8" "995.4" "972.4" "1048.0" "1020.2" "1036.6" "1047.2" "1019.8" "914.7" "" "" "" "" "" "" "" "" "" "" "936.2" "790.4" "900.4" "949.2" "864.8" "1020.2" "776.2" "924.9" "912.5" "326.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7392710609967527407" "False" "High" "IsMasterProtein" "Q96BH1" "E3 ubiquitin-protein ligase RNF25 OS=Homo sapiens OX=9606 GN=RNF25 PE=1 SV=1" "0.000" "False" "30.463" "20" "7" "10" "7" "459" "51.2" "6.54" "33.13" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus" "other molecular function" "Pf05773, Pf13639" "64320" "ENSG00000163481" "RNF25" "A8K0D6; hsa:64320; Q53HQ5; Q96BH1; Q9H874" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.940" "1.086" "0.979" "1.074" "1.023" "0.968" "1.016" "0.994" "0.841" "578.9" "544.2" "628.6" "566.9" "621.5" "592.5" "560.3" "588.0" "575.4" "486.6" "" "" "" "" "" "" "" "" "" "" "520.5" "440.3" "568.6" "553.3" "512.9" "592.5" "419.5" "519.3" "514.9" "173.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3695777178307527150" "False" "High" "IsMasterProtein" "Q9BZL1" "Ubiquitin-like protein 5 OS=Homo sapiens OX=9606 GN=UBL5 PE=1 SV=1" "0.000" "False" "30.462" "70" "5" "12" "5" "73" "8.5" "8.44" "42.77" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00240" "59286" "ENSG00000198258" "UBL5" "hsa:59286; Q2NL89; Q9BZL1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.997" "1.148" "0.912" "0.983" "1.117" "0.927" "0.969" "1.090" "1.190" "1533.6" "1529.7" "1760.4" "1399.0" "1507.2" "1713.2" "1421.2" "1485.5" "1672.2" "1825.6" "" "" "" "" "" "" "" "" "" "" "1378.8" "1237.8" "1592.3" "1365.6" "1243.8" "1713.2" "1064.2" "1312.1" "1496.3" "651.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3771039295331557619" "False" "High" "IsMasterProtein" "P12694" "2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHA PE=1 SV=2" "0.000" "False" "30.452" "21" "8" "12" "8" "445" "50.4" "8.27" "41.68" "8" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00676" "593" "ENSG00000248098" "BCKDHA" "B4DP47; E7EW46; hsa:593; P12694; Q16034; Q16472" "Lipid metabolism pathway" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.018" "0.987" "1.033" "1.100" "1.060" "1.012" "1.029" "1.082" "0.918" "911.1" "927.5" "899.4" "940.8" "1002.0" "965.8" "922.5" "938.0" "985.5" "836.7" "" "" "" "" "" "" "" "" "" "" "819.2" "750.5" "813.6" "918.4" "826.8" "965.8" "690.8" "828.5" "881.8" "298.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6065007746744177820" "False" "High" "IsMasterProtein" "Q9ULZ2" "Signal-transducing adaptor protein 1 OS=Homo sapiens OX=9606 GN=STAP1 PE=1 SV=1" "0.000" "False" "30.371" "32" "9" "12" "9" "295" "34.3" "7.77" "43.01" "9" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00169" "26228" "ENSG00000035720" "STAP1" "B2R980; hsa:26228; Q9ULZ2" "" "" "0" "0" "1.073" "1.087" "0.999" "1.035" "0.942" "1.019" "0.948" "0.985" "3.410" "902.2" "968.3" "981.0" "901.4" "933.8" "849.6" "919.7" "855.5" "888.3" "3076.8" "" "" "" "" "" "" "" "" "" "" "811.2" "783.5" "887.4" "879.8" "770.6" "849.6" "688.7" "755.7" "794.9" "1098.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7331213768411445402" "False" "High" "IsMasterProtein" "O95777" "U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens OX=9606 GN=LSM8 PE=1 SV=3" "0.000" "False" "30.369" "69" "5" "20" "5" "96" "10.4" "4.48" "98.01" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51691" "ENSG00000128534" "LSM8" "hsa:51691; O95777" "" "mRNA Splicing - Major Pathway" "1" "0" "0.966" "1.008" "0.920" "1.061" "0.986" "0.975" "1.010" "0.956" "0.763" "1040.6" "1004.8" "1048.7" "957.8" "1103.8" "1026.1" "1014.3" "1050.9" "995.2" "794.0" "" "" "" "" "" "" "" "" "" "" "935.6" "813.0" "948.6" "934.9" "910.9" "1026.1" "759.5" "928.2" "890.5" "283.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1124967282390941354" "False" "High" "IsMasterProtein" "Q9HB90" "Ras-related GTP-binding protein C OS=Homo sapiens OX=9606 GN=RRAGC PE=1 SV=1" "0.000" "False" "30.359" "25" "9" "9" "9" "399" "44.2" "5.10" "28.65" "9" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "64121" "ENSG00000116954" "RRAGC" "hsa:64121; Q9H202; Q9H8Q8; Q9HB90" "Target of rapamycin signaling; Orexin receptor pathway; 2q37 copy number variation syndrome" "Regulation of PTEN gene transcription; TP53 Regulates Metabolic Genes; Amino acids regulate mTORC1; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "10" "0" "1.101" "1.102" "0.923" "1.102" "1.095" "0.901" "0.980" "1.139" "0.748" "359.8" "396.4" "396.6" "332.0" "396.6" "394.1" "324.1" "352.5" "410.0" "269.1" "" "" "" "" "" "" "" "" "" "" "323.5" "320.7" "358.8" "324.1" "327.3" "394.1" "242.7" "311.3" "366.9" "96.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794810011178551467" "False" "High" "IsMasterProtein" "O75348" "V-type proton ATPase subunit G 1 OS=Homo sapiens OX=9606 GN=ATP6V1G1 PE=1 SV=3" "0.000" "False" "30.356" "59" "7" "12" "7" "118" "13.7" "8.79" "40.21" "7" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "9550" "ENSG00000136888" "ATP6V1G1" "hsa:9550; O75348; Q6IB33" "Osteoclast signaling; Proximal tubule transport" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.054" "0.974" "1.011" "0.893" "1.025" "1.028" "1.044" "0.938" "0.809" "1329.2" "1401.0" "1294.0" "1344.4" "1187.4" "1361.9" "1366.9" "1387.0" "1247.4" "1074.8" "" "" "" "" "" "" "" "" "" "" "1195.0" "1133.6" "1170.4" "1312.3" "979.8" "1361.9" "1023.5" "1225.1" "1116.2" "383.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7021380242978739287" "False" "High" "IsMasterProtein" "Q92797" "Symplekin OS=Homo sapiens OX=9606 GN=SYMPK PE=1 SV=2" "0.000" "False" "30.345" "9" "13" "14" "13" "1274" "141.1" "6.13" "43.55" "13" "cell adhesion;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf11935, Pf12295" "8189" "ENSG00000125755" "SYMPK" "hsa:8189; O00521; O00689; O00733; Q59GT5; Q8N2U5; Q92797" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "5" "0" "1.014" "1.048" "1.003" "0.957" "0.997" "1.028" "0.928" "0.828" "2.540" "554.1" "561.8" "580.5" "555.5" "530.4" "552.4" "569.8" "514.0" "458.7" "1407.5" "" "" "" "" "" "" "" "" "" "" "498.2" "454.6" "525.1" "542.2" "437.7" "552.4" "426.7" "454.0" "410.4" "502.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1597744866915900932" "False" "High" "IsMasterProtein" "P51114" "RNA-binding protein FXR1 OS=Homo sapiens OX=9606 GN=FXR1 PE=1 SV=3" "0.000" "False" "30.333" "14" "9" "9" "7" "621" "69.7" "6.15" "32.17" "9" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf16097, Pf17904, Pf18336" "8087" "ENSG00000114416" "FXR1" "A8K9B8; hsa:8087; P51114; Q7Z450; Q8N6R8" "Bile acids synthesis and enterohepatic circulation" "Signaling by BRAF and RAF1 fusions" "2" "2" "1.035" "1.017" "0.961" "1.077" "1.088" "1.032" "0.979" "1.116" "2.621" "697.7" "722.0" "709.4" "670.2" "751.8" "759.3" "719.8" "683.3" "778.8" "1828.6" "" "" "" "" "" "" "" "" "" "" "627.3" "584.2" "641.6" "654.2" "620.4" "759.3" "539.0" "603.5" "696.9" "652.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-445851658510322323" "False" "High" "IsMasterProtein" "P55769" "NHP2-like protein 1 OS=Homo sapiens OX=9606 GN=SNU13 PE=1 SV=3" "0.000" "False" "30.330" "52" "6" "11" "6" "128" "14.2" "8.46" "44.64" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "4809" "ENSG00000100138" "SNU13" "hsa:4809; P55769" "mRNA processing" "mRNA Splicing - Major Pathway; Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "1.150" "1.047" "1.205" "0.995" "1.253" "1.078" "1.168" "1.045" "0.977" "1514.4" "1741.2" "1585.3" "1824.2" "1506.1" "1898.1" "1632.7" "1768.3" "1582.3" "1479.3" "" "" "" "" "" "" "" "" "" "" "1361.6" "1408.9" "1434.0" "1780.7" "1242.8" "1898.1" "1222.5" "1561.8" "1415.8" "528.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494300980345175756" "False" "High" "IsMasterProtein" "P48059" "LIM and senescent cell antigen-like-containing domain protein 1 OS=Homo sapiens OX=9606 GN=LIMS1 PE=1 SV=4" "0.000" "False" "30.298" "31" "8" "10" "8" "325" "37.2" "8.05" "34.08" "8" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00412" "3987" "ENSG00000169756" "LIMS1" "B2RAJ4; B7Z483; B7Z7R3; B7Z907; hsa:3987; P48059; Q53TE0; Q9BS44" "Primary focal segmental glomerulosclerosis (FSGS)" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "0.896" "0.984" "0.953" "1.037" "0.917" "0.972" "1.062" "0.966" "0.808" "713.4" "639.5" "702.3" "680.2" "739.7" "654.0" "693.5" "757.5" "688.9" "576.5" "" "" "" "" "" "" "" "" "" "" "641.4" "517.4" "635.3" "664.0" "610.4" "654.0" "519.3" "669.1" "616.5" "205.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257643935121491465" "False" "High" "IsMasterProtein" "Q15120" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial OS=Homo sapiens OX=9606 GN=PDK3 PE=1 SV=1" "0.000" "False" "30.290" "19" "7" "9" "7" "406" "46.9" "8.37" "34.42" "7" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5165" "ENSG00000067992" "PDK3" "B4DXG6; hsa:5165; Q15120" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "0.974" "0.908" "0.958" "0.962" "0.947" "0.997" "1.004" "0.956" "0.836" "482.0" "469.4" "437.5" "461.9" "463.6" "456.3" "480.4" "483.7" "461.0" "403.0" "" "" "" "" "" "" "" "" "" "" "433.4" "379.8" "395.7" "450.8" "382.6" "456.3" "359.7" "427.3" "412.5" "143.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517606527837170781" "False" "High" "IsMasterProtein" "Q9Y5P6" "Mannose-1-phosphate guanyltransferase beta OS=Homo sapiens OX=9606 GN=GMPPB PE=1 SV=2" "0.000" "False" "30.215" "29" "7" "10" "7" "360" "39.8" "6.61" "37.61" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29925" "ENSG00000173540" "GMPPB" "A8K6N5; hsa:29925; Q9H7U3; Q9Y5P6" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.018" "1.009" "0.994" "0.985" "0.984" "0.960" "1.005" "1.046" "0.824" "887.0" "902.6" "895.3" "881.4" "873.5" "872.9" "851.9" "891.5" "928.0" "730.8" "" "" "" "" "" "" "" "" "" "" "797.5" "730.3" "809.9" "860.3" "720.9" "872.9" "637.9" "787.4" "830.4" "260.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5097662091813912850" "False" "High" "IsMasterProtein" "Q02252" "Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Homo sapiens OX=9606 GN=ALDH6A1 PE=1 SV=2" "0.000" "False" "30.179" "18" "9" "9" "9" "535" "57.8" "8.50" "30.23" "9" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf00171" "4329" "ENSG00000119711" "ALDH6A1" "B2R609; B4DFS8; hsa:4329; J3KNU8; Q02252; Q9UKM8" "" "Branched-chain amino acid catabolism" "1" "0" "1.073" "1.173" "1.049" "1.179" "1.180" "1.134" "1.181" "1.257" "1.287" "776.5" "832.9" "910.4" "814.4" "915.4" "916.2" "880.5" "917.4" "976.1" "999.6" "" "" "" "" "" "" "" "" "" "" "698.1" "674.0" "823.5" "794.9" "755.4" "916.2" "659.3" "810.3" "873.4" "356.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128972635678329678" "False" "High" "IsMasterProtein" "Q9BUT1" "Dehydrogenase/reductase SDR family member 6 OS=Homo sapiens OX=9606 GN=BDH2 PE=1 SV=2" "0.000" "False" "30.172" "36" "8" "10" "8" "245" "26.7" "7.65" "33.80" "8" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13561" "56898" "ENSG00000164039" "BDH2" "A8K295; B4DUF6; hsa:56898; Q503A0; Q6IA46; Q6UWD3; Q9BUT1; Q9H8S8; Q9NRX8" "" "Synthesis of Ketone Bodies" "1" "0" "1.045" "1.006" "0.920" "1.036" "1.030" "0.991" "0.954" "1.015" "0.976" "1031.5" "1078.1" "1037.8" "948.7" "1068.9" "1062.1" "1022.0" "984.5" "1047.2" "1006.5" "" "" "" "" "" "" "" "" "" "" "927.4" "872.4" "938.8" "926.1" "882.1" "1062.1" "765.2" "869.6" "937.0" "359.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6138498598484703965" "False" "High" "IsMasterProtein" "P30405" "Peptidyl-prolyl cis-trans isomerase F, mitochondrial OS=Homo sapiens OX=9606 GN=PPIF PE=1 SV=1" "0.000" "False" "30.169" "33" "11" "17" "9" "207" "22.0" "9.38" "50.81" "11" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00160" "10105" "ENSG00000108179" "PPIF" "hsa:10105; P30405; Q2YDB7; Q5W131" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "1" "0.961" "0.995" "1.022" "1.024" "0.987" "1.028" "0.997" "1.003" "0.778" "2272.2" "2182.6" "2260.3" "2323.1" "2326.4" "2241.7" "2336.1" "2265.9" "2279.9" "1767.1" "" "" "" "" "" "" "" "" "" "" "2042.9" "1766.1" "2044.5" "2267.6" "1919.8" "2241.7" "1749.2" "2001.4" "2040.0" "630.8" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4996953049836216410" "False" "High" "IsMasterProtein" "O14618" "Copper chaperone for superoxide dismutase OS=Homo sapiens OX=9606 GN=CCS PE=1 SV=1" "0.000" "False" "30.040" "32" "7" "9" "7" "274" "29.0" "5.58" "42.81" "7" "protein metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "other molecular function" "Pf00080, Pf00403" "9973" "ENSG00000173992" "CCS" "hsa:9973; O14618; Q2M366; Q8NEV0" "Amyotrophic lateral sclerosis (ALS); Copper homeostasis" "Detoxification of Reactive Oxygen Species" "3" "0" "0.944" "0.992" "0.926" "0.987" "0.988" "0.983" "0.926" "0.937" "0.994" "921.5" "870.2" "913.9" "853.1" "909.3" "910.1" "905.6" "853.6" "863.3" "915.7" "" "" "" "" "" "" "" "" "" "" "828.5" "704.1" "826.7" "832.7" "750.3" "910.1" "678.1" "754.0" "772.5" "326.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1347928425928225454" "False" "High" "IsMasterProtein" "O60925" "Prefoldin subunit 1 OS=Homo sapiens OX=9606 GN=PFDN1 PE=1 SV=2" "0.000" "False" "30.035" "55" "6" "12" "6" "122" "14.2" "6.81" "41.27" "6" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "5201" "ENSG00000113068" "PFDN1" "B2RD02; hsa:5201; O60925; Q53F95; Q96EX6" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.984" "0.985" "0.904" "0.982" "0.992" "1.012" "1.026" "0.982" "0.786" "1465.3" "1441.6" "1443.5" "1324.8" "1439.0" "1453.2" "1482.1" "1503.9" "1438.8" "1151.8" "" "" "" "" "" "" "" "" "" "" "1317.4" "1166.5" "1305.7" "1293.2" "1187.5" "1453.2" "1109.8" "1328.3" "1287.4" "411.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801357975470055423" "False" "High" "IsMasterProtein" "O14526" "F-BAR domain only protein 1 OS=Homo sapiens OX=9606 GN=FCHO1 PE=1 SV=2" "0.000" "False" "30.019" "11" "9" "10" "9" "889" "96.8" "6.96" "37.81" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00611, Pf10291" "23149" "ENSG00000130475" "FCHO1" "A6NHE6; A8K5U5; B4E120; hsa:23149; O14526; Q05C93; Q8IW22" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.096" "1.049" "1.016" "1.108" "1.072" "1.146" "1.052" "1.014" "1.456" "598.2" "655.9" "627.2" "607.7" "663.0" "641.6" "685.8" "629.2" "606.7" "871.0" "" "" "" "" "" "" "" "" "" "" "537.9" "530.7" "567.4" "593.2" "547.1" "641.6" "513.5" "555.7" "542.9" "310.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6933649257231024003" "False" "High" "IsMasterProtein" "P16930" "Fumarylacetoacetase OS=Homo sapiens OX=9606 GN=FAH PE=1 SV=2" "0.000" "False" "29.999" "20" "7" "8" "7" "419" "46.3" "6.95" "31.52" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf01557, Pf09298" "2184" "ENSG00000103876" "FAH" "B2R9X1; D3DW95; hsa:2184; P16930; Q53XA7" "Amino acid metabolism" "Tyrosine catabolism" "2" "0" "1.077" "1.113" "1.094" "1.176" "1.090" "1.142" "1.022" "1.168" "0.887" "797.4" "858.7" "887.2" "872.3" "937.6" "869.2" "911.0" "814.6" "931.3" "707.3" "" "" "" "" "" "" "" "" "" "" "716.9" "694.8" "802.5" "851.5" "773.7" "869.2" "682.1" "719.5" "833.3" "252.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2085339884306235514" "False" "High" "IsMasterProtein" "Q13501" "Sequestosome-1 OS=Homo sapiens OX=9606 GN=SQSTM1 PE=1 SV=1" "0.000" "False" "29.993" "24" "6" "8" "6" "440" "47.7" "5.22" "38.79" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00564, Pf00569, Pf16577" "8878" "ENSG00000161011; ENSG00000284099" "SQSTM1" "A6NFN7; B2R661; B3KUW5; hsa:8878; Q13446; Q13501; Q9BUV7; Q9BVS6; Q9UEU1" "IL-1 signaling pathway; RANKL/RANK signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Nuclear receptors meta-pathway; NRF2 pathway; Interleukin-1 induced activation of NF-kB; Clear cell renal cell carcinoma pathways; CAMKK2 pathway; 7q11.23 copy number variation syndrome; Opioid receptor pathways; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; HDAC6 interactions in the central nervous system" "KEAP1-NFE2L2 pathway; Neddylation; Interleukin-1 signaling; Signaling by ALK fusions and activated point mutants; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; Nuclear events mediated by NFE2L2; PINK1-PRKN Mediated Mitophagy; NRIF signals cell death from the nucleus; Pexophagy" "24" "0" "1.012" "1.097" "1.093" "1.067" "1.125" "1.078" "1.090" "1.199" "1.074" "425.2" "430.4" "466.3" "464.7" "453.5" "478.4" "458.2" "463.6" "509.8" "456.7" "" "" "" "" "" "" "" "" "" "" "382.3" "348.2" "421.8" "453.6" "374.3" "478.4" "343.1" "409.5" "456.1" "163.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842107794335973179" "False" "High" "IsMasterProtein" "P15336" "Cyclic AMP-dependent transcription factor ATF-2 OS=Homo sapiens OX=9606 GN=ATF2 PE=1 SV=4" "0.000" "False" "29.982" "17" "9" "11" "6" "505" "54.5" "7.88" "37.60" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "1386" "ENSG00000115966" "ATF2" "A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5; hsa:1386; P15336; Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; Q96JT8" "Energy metabolism; IL-1 signaling pathway; B cell receptor signaling pathway; AGE/RAGE pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Myometrial relaxation and contraction pathways; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; DNA IR-double strand breaks and cellular response via ATM; Ethanol effects on histone modifications; p38 MAPK signaling pathway; PI3K-Akt signaling pathway; Thermogenesis; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; 10q11.21q11.23 copy number variation syndrome; T-cell receptor signaling pathway" "Heme signaling; NGF-stimulated transcription; Regulation of PTEN gene transcription; TP53 Regulates Transcription of DNA Repair Genes; Circadian Clock; Transcriptional activation of mitochondrial biogenesis; Estrogen-dependent gene expression; HATs acetylate histones; Activation of the AP-1 family of transcription factors; Response of EIF2AK4 (GCN2) to amino acid deficiency" "36" "0" "1.011" "1.045" "0.964" "1.097" "1.062" "1.125" "1.092" "1.061" "0.881" "1273.3" "1287.5" "1330.2" "1228.1" "1396.5" "1352.1" "1432.4" "1390.2" "1351.4" "1121.7" "" "" "" "" "" "" "" "" "" "" "1144.9" "1041.8" "1203.2" "1198.8" "1152.4" "1352.1" "1072.5" "1227.9" "1209.2" "400.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8668239743978999828" "False" "High" "IsMasterProtein" "Q9NSI2" "Ribosome biogenesis protein SLX9 homolog OS=Homo sapiens OX=9606 GN=SLX9 PE=1 SV=2" "0.000" "False" "29.974" "31" "6" "9" "6" "230" "25.4" "11.08" "32.38" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf15341" "85395" "ENSG00000160256" "SLX9" "hsa:85395; Q9NSI2" "" "" "0" "0" "1.001" "0.788" "1.004" "1.045" "0.787" "0.977" "1.060" "0.847" "1.576" "484.9" "485.2" "382.1" "487.0" "506.6" "381.4" "473.6" "514.2" "411.0" "764.3" "" "" "" "" "" "" "" "" "" "" "436.0" "392.6" "345.6" "475.3" "418.1" "381.4" "354.6" "454.2" "367.7" "272.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7784023466259841542" "False" "High" "IsMasterProtein" "B0I1T2" "Unconventional myosin-Ig OS=Homo sapiens OX=9606 GN=MYO1G PE=1 SV=2" "0.000" "False" "29.962" "12" "9" "9" "9" "1018" "116.4" "8.73" "34.78" "9" "cell adhesion;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf06017" "64005" "ENSG00000136286" "MYO1G" "B0I1T2; hsa:64005; Q8TEI9; Q8TES2; Q96BE2; Q96RI5; Q96RI6" "" "" "0" "0" "0.946" "0.914" "0.926" "0.864" "0.906" "0.942" "0.885" "0.965" "0.705" "514.2" "486.5" "469.8" "476.1" "444.2" "465.7" "484.2" "455.3" "496.2" "362.5" "" "" "" "" "" "" "" "" "" "" "462.4" "393.6" "425.0" "464.7" "366.5" "465.7" "362.6" "402.1" "444.0" "129.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5702774175857427246" "False" "High" "IsMasterProtein" "Q02078" "Myocyte-specific enhancer factor 2A OS=Homo sapiens OX=9606 GN=MEF2A PE=1 SV=1" "0.000" "False" "29.956" "16" "6" "14" "4" "507" "54.8" "7.91" "42.98" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319, Pf12347" "4205" "ENSG00000068305" "MEF2A" "B4DFQ7; F6XG23; hsa:4205; O43814; Q02078; Q14223; Q14224; Q59GX4; Q7Z6C9; Q96D14" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; TGF-beta signaling pathway; EGF/EGFR signaling pathway; IL-18 signaling pathway; 2q37 copy number variation syndrome" "Myogenesis; ERK/MAPK targets" "13" "0" "1.025" "0.963" "0.952" "1.059" "0.978" "1.002" "0.935" "1.000" "1.908" "474.8" "486.9" "457.2" "452.1" "502.9" "464.5" "475.5" "444.1" "474.6" "905.8" "" "" "" "" "" "" "" "" "" "" "426.9" "394.0" "413.6" "441.3" "415.0" "464.5" "356.1" "392.3" "424.7" "323.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5029706333006790084" "False" "High" "IsMasterProtein" "Q5VT52" "Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens OX=9606 GN=RPRD2 PE=1 SV=1" "0.000" "False" "29.923" "7" "10" "12" "10" "1461" "155.9" "7.42" "33.97" "10" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818" "23248" "ENSG00000163125" "RPRD2" "A8K6N8; B3KPT1; B4E2Q6; hsa:23248; O75048; Q5VT51; Q5VT52; Q5VT53; Q6MZL4; Q86XD2; Q9P0D7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.956" "0.899" "1.030" "0.980" "0.960" "1.055" "0.943" "0.985" "1.540" "606.0" "579.4" "544.9" "624.1" "593.7" "581.7" "639.3" "571.7" "597.2" "933.3" "" "" "" "" "" "" "" "" "" "" "544.9" "468.9" "492.9" "609.2" "490.0" "581.7" "478.7" "505.0" "534.4" "333.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5241124612822470915" "False" "High" "IsMasterProtein" "P36639" "Oxidized purine nucleoside triphosphate hydrolase OS=Homo sapiens OX=9606 GN=NUDT1 PE=1 SV=4" "0.000" "False" "29.912" "34" "6" "13" "6" "156" "17.9" "5.08" "57.04" "6" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "4521" "ENSG00000106268" "NUDT1" "A4D205; hsa:4521; P36639; Q6LES7; Q6P0Y6; Q7Z7N6; Q8IV95; Q9UBM0; Q9UBM9" "" "" "0" "0" "1.012" "1.164" "1.046" "1.019" "1.083" "0.996" "1.014" "1.039" "2.267" "1084.7" "1097.3" "1262.3" "1134.2" "1105.0" "1175.0" "1080.7" "1100.1" "1127.0" "2458.5" "" "" "" "" "" "" "" "" "" "" "975.3" "887.9" "1141.8" "1107.2" "911.9" "1175.0" "809.2" "971.7" "1008.5" "877.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7849372490440627698" "False" "High" "IsMasterProtein" "Q96P16" "Regulation of nuclear pre-mRNA domain-containing protein 1A OS=Homo sapiens OX=9606 GN=RPRD1A PE=1 SV=1" "0.000" "False" "29.907" "38" "8" "8" "7" "312" "35.7" "7.55" "32.91" "8" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04818, Pf16566" "55197" "ENSG00000141425" "RPRD1A" "A8KA42; B2RBA3; hsa:55197; Q7Z5G8; Q96FY9; Q96P16; Q9NVL4" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.006" "1.033" "1.037" "1.123" "1.069" "1.150" "1.007" "1.084" "2.034" "425.8" "428.1" "439.9" "441.4" "478.2" "455.0" "489.7" "428.6" "461.7" "866.0" "" "" "" "" "" "" "" "" "" "" "382.8" "346.4" "397.9" "430.8" "394.6" "455.0" "366.6" "378.5" "413.1" "309.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4173136633731686100" "False" "High" "IsMasterProtein" "P29590" "Protein PML OS=Homo sapiens OX=9606 GN=PML PE=1 SV=3" "0.000" "False" "29.899" "11" "9" "10" "9" "882" "97.5" "6.21" "29.68" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00643, Pf12126" "5371" "ENSG00000140464" "PML" "E9PBR7; hsa:5371; P29590; P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; Q9BZX6; Q9BZX7; Q9BZX8; Q9BZX9; Q9BZY0; Q9BZY2; Q9BZY3" "miRNA regulation of DNA damage response; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; p53 transcriptional gene network; Acute myeloid leukemia; DNA damage response" "HCMV Early Events; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Interferon gamma signaling; Regulation of TP53 Activity through Acetylation; Regulation of PTEN localization; Regulation of RUNX1 Expression and Activity" "13" "0" "0.952" "1.029" "0.983" "1.000" "0.975" "1.025" "0.957" "0.970" "1.498" "821.7" "782.0" "845.8" "807.8" "821.6" "801.1" "842.6" "786.5" "797.1" "1231.1" "" "" "" "" "" "" "" "" "" "" "738.8" "632.8" "765.1" "788.5" "678.0" "801.1" "630.9" "694.7" "713.3" "439.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4718319405373936898" "False" "High" "IsMasterProtein" "Q5TA45" "Integrator complex subunit 11 OS=Homo sapiens OX=9606 GN=INTS11 PE=1 SV=2" "0.000" "False" "29.882" "17" "9" "10" "9" "600" "67.6" "8.06" "34.47" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07521, Pf10996, Pf16661, Pf21386" "54973" "ENSG00000127054" "INTS11" "A8K5S2; B3KPR3; B4DM87; G3V1S5; hsa:54973; Q5TA45; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.061" "1.064" "0.983" "1.095" "1.049" "1.013" "0.996" "1.076" "1.226" "611.3" "648.7" "650.3" "601.1" "669.2" "641.2" "619.5" "609.1" "658.0" "749.4" "" "" "" "" "" "" "" "" "" "" "549.6" "524.9" "588.2" "586.7" "552.3" "641.2" "463.9" "538.0" "588.8" "267.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "107248944887719922" "False" "High" "IsMasterProtein" "Q6VN20" "Ran-binding protein 10 OS=Homo sapiens OX=9606 GN=RANBP10 PE=1 SV=1" "0.000" "False" "29.850" "10" "5" "10" "5" "620" "67.2" "6.77" "34.44" "5" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf00622, Pf08513, Pf10607" "57610" "ENSG00000141084" "RANBP10" "A4FTY2; B4DID0; B4DQH9; E7EW27; hsa:57610; Q6VN20; Q9P264" "Ciliary landscape" "MET activates RAS signaling" "2" "0" "1.142" "1.048" "1.013" "1.057" "1.026" "0.977" "1.022" "0.991" "0.913" "340.7" "388.9" "357.1" "345.0" "360.2" "349.6" "332.8" "348.1" "337.4" "311.1" "" "" "" "" "" "" "" "" "" "" "306.3" "314.7" "323.0" "336.8" "297.2" "349.6" "249.2" "307.5" "301.9" "111.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7779362395337591117" "False" "High" "IsMasterProtein" "Q96FX7" "tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Homo sapiens OX=9606 GN=TRMT61A PE=1 SV=1" "0.000" "False" "29.812" "33" "6" "9" "6" "289" "31.4" "7.36" "40.42" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf08704" "115708" "ENSG00000166166" "TRMT61A" "A6NN78; hsa:115708; Q8N7Q9; Q96FX7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.017" "1.062" "1.106" "1.057" "1.120" "1.090" "1.062" "1.117" "0.940" "622.9" "633.6" "661.8" "688.9" "658.4" "698.0" "678.8" "661.3" "695.9" "585.8" "" "" "" "" "" "" "" "" "" "" "560.1" "512.7" "598.7" "672.5" "543.3" "698.0" "508.3" "584.1" "622.7" "209.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8898508644132712333" "False" "High" "IsMasterProtein" "Q01130" "Serine/arginine-rich splicing factor 2 OS=Homo sapiens OX=9606 GN=SRSF2 PE=1 SV=4" "0.000" "False" "29.770" "19" "5" "14" "5" "221" "25.5" "11.85" "53.79" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "6427" "ENSG00000161547" "SRSF2" "B3KWD5; B4DN89; H0YG49; hsa:6427; Q01130" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Minor Pathway" "7" "0" "0.947" "1.036" "0.945" "1.035" "1.038" "0.929" "0.989" "0.929" "0.951" "693.6" "656.8" "718.4" "655.8" "717.8" "720.3" "644.3" "686.1" "644.3" "659.3" "" "" "" "" "" "" "" "" "" "" "623.6" "531.4" "649.8" "640.1" "592.3" "720.3" "482.4" "606.0" "576.5" "235.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2645630736488314632" "False" "High" "IsMasterProtein" "P04080" "Cystatin-B OS=Homo sapiens OX=9606 GN=CSTB PE=1 SV=2" "0.000" "False" "29.769" "70" "6" "13" "6" "98" "11.1" "7.56" "53.89" "6" "other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00031" "1476" "ENSG00000160213" "CSTB" "hsa:1476; P04080" "" "Neutrophil degranulation" "1" "0" "0.975" "0.985" "0.987" "0.852" "1.095" "0.919" "1.062" "0.905" "0.721" "1332.6" "1299.5" "1312.6" "1315.5" "1135.9" "1458.8" "1224.1" "1415.1" "1206.2" "960.2" "" "" "" "" "" "" "" "" "" "" "1198.2" "1051.5" "1187.3" "1284.1" "937.3" "1458.8" "916.6" "1249.9" "1079.3" "342.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8378095313839820512" "False" "High" "IsMasterProtein" "P15923" "Transcription factor E2-alpha OS=Homo sapiens OX=9606 GN=TCF3 PE=1 SV=1" "0.000" "False" "29.743" "14" "8" "9" "8" "654" "67.6" "6.47" "36.22" "8" "DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6929" "ENSG00000071564" "TCF3" "hsa:6929; P15883; P15923; Q14208; Q14635; Q14636; Q2TB39; Q2TB40; Q9UPI9" "Ectoderm differentiation; Ectoderm differentiation; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; lncRNA in canonical Wnt signaling and colorectal cancer; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Myogenesis" "9" "0" "0.979" "0.821" "1.067" "1.098" "0.906" "1.151" "1.099" "0.960" "2.110" "409.7" "401.0" "336.2" "437.3" "449.7" "371.1" "471.5" "450.4" "393.2" "864.3" "" "" "" "" "" "" "" "" "" "" "368.4" "324.4" "304.1" "426.8" "371.1" "371.1" "353.1" "397.8" "351.8" "308.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2794156240078795368" "False" "High" "IsMasterProtein" "Q8NEZ5" "F-box only protein 22 OS=Homo sapiens OX=9606 GN=FBXO22 PE=1 SV=1" "0.000" "False" "29.743" "22" "8" "10" "8" "403" "44.5" "7.03" "37.09" "8" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00646, Pf10442" "26263" "ENSG00000167196" "FBXO22" "hsa:26263; Q0D2P8; Q6PIL5; Q8IXW3; Q8NEZ5; Q9H824; Q9UKC0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.072" "1.071" "0.917" "1.039" "1.050" "1.085" "0.947" "1.080" "0.820" "677.2" "725.9" "725.6" "621.1" "703.6" "711.0" "735.0" "641.3" "731.3" "555.5" "" "" "" "" "" "" "" "" "" "" "608.9" "587.4" "656.3" "606.3" "580.6" "711.0" "550.3" "566.5" "654.4" "198.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100353375695918439" "False" "High" "IsMasterProtein" "P53999" "Activated RNA polymerase II transcriptional coactivator p15 OS=Homo sapiens OX=9606 GN=SUB1 PE=1 SV=3" "0.000" "False" "29.713" "40" "4" "13" "4" "127" "14.4" "9.60" "48.97" "4" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02229" "10923" "ENSG00000113387" "SUB1" "hsa:10923; P53999; Q96L29" "" "" "0" "0" "0.934" "0.976" "0.957" "1.004" "0.982" "1.001" "1.014" "0.983" "0.786" "1754.8" "1639.7" "1712.7" "1678.5" "1761.8" "1723.5" "1757.1" "1779.9" "1725.0" "1380.1" "" "" "" "" "" "" "" "" "" "" "1577.7" "1326.8" "1549.2" "1638.4" "1453.9" "1723.5" "1315.6" "1572.1" "1543.5" "492.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2780012699029809096" "False" "High" "IsMasterProtein" "Q9H9J2" "Large ribosomal subunit protein mL44 OS=Homo sapiens OX=9606 GN=MRPL44 PE=1 SV=1" "0.000" "False" "29.696" "20" "5" "7" "5" "332" "37.5" "8.40" "34.19" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "" "65080" "ENSG00000135900" "MRPL44" "hsa:65080; Q53S16; Q6IA62; Q9H821; Q9H9J2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.058" "0.984" "1.017" "1.055" "0.989" "1.030" "1.058" "1.051" "1.237" "1177.2" "1246.0" "1159.0" "1197.4" "1241.4" "1163.9" "1212.8" "1245.1" "1237.5" "1455.9" "" "" "" "" "" "" "" "" "" "" "1058.4" "1008.3" "1048.3" "1168.9" "1024.4" "1163.9" "908.1" "1099.7" "1107.3" "519.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5399791769626457574" "False" "High" "IsMasterProtein" "Q9UMS0" "NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Homo sapiens OX=9606 GN=NFU1 PE=1 SV=2" "0.000" "False" "29.674" "30" "6" "9" "6" "254" "28.4" "5.07" "36.15" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf01106, Pf08712" "27247" "ENSG00000169599" "NFU1" "B4DUL9; hsa:27247; Q53QE5; Q6VNZ8; Q7Z5B1; Q7Z5B2; Q9UMS0; Q9Y322" "Iron-sulfur cluster biogenesis" "" "1" "0" "0.928" "0.938" "0.977" "1.018" "0.983" "0.970" "1.011" "0.982" "0.791" "1061.2" "985.3" "995.0" "1036.8" "1080.3" "1042.8" "1029.1" "1073.1" "1041.7" "839.0" "" "" "" "" "" "" "" "" "" "" "954.1" "797.3" "900.0" "1012.0" "891.5" "1042.8" "770.6" "947.8" "932.1" "299.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9195295084740601325" "False" "High" "IsMasterProtein" "Q00577" "Transcriptional activator protein Pur-alpha OS=Homo sapiens OX=9606 GN=PURA PE=1 SV=2" "0.000" "False" "29.638" "30" "7" "10" "7" "322" "34.9" "6.44" "40.61" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04845" "5813" "ENSG00000185129" "PURA" "hsa:5813; Q00577" "Exercise-induced circadian regulation" "" "1" "0" "1.063" "0.990" "0.956" "1.017" "1.040" "0.923" "1.006" "1.043" "0.832" "323.5" "344.0" "320.1" "309.2" "329.2" "336.4" "298.7" "325.4" "337.5" "269.1" "" "" "" "" "" "" "" "" "" "" "290.9" "278.3" "289.6" "301.8" "271.6" "336.4" "223.7" "287.4" "302.0" "96.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7841395992400372766" "False" "High" "IsMasterProtein" "Q9NVG8" "TBC1 domain family member 13 OS=Homo sapiens OX=9606 GN=TBC1D13 PE=1 SV=3" "0.000" "False" "29.630" "19" "7" "9" "7" "400" "46.5" "5.24" "32.79" "7" "transport" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf00566" "54662" "ENSG00000107021" "TBC1D13" "A7E2E7; B3KW04; B9EGJ8; hsa:54662; Q5T270; Q5T271; Q9NVG8" "" "TBC/RABGAPs" "1" "0" "1.033" "1.007" "1.044" "1.005" "1.014" "1.047" "0.973" "1.049" "0.892" "366.6" "378.7" "369.1" "382.8" "368.4" "371.9" "384.0" "356.5" "384.7" "326.9" "" "" "" "" "" "" "" "" "" "" "329.6" "306.5" "333.9" "373.7" "304.0" "371.9" "287.5" "314.9" "344.2" "116.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5959854138225624200" "False" "High" "IsMasterProtein" "Q7Z6E9" "E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens OX=9606 GN=RBBP6 PE=1 SV=1" "0.000" "False" "29.627" "5" "7" "9" "7" "1792" "201.4" "9.64" "29.11" "7" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04564, Pf08783, Pf13696" "5930" "ENSG00000122257" "RBBP6" "Q147T5; Q15290; Q6DKH4; Q6P4C2; Q6YNC9; Q7Z6E8; Q7Z6E9; Q8N0V2; Q96PH3; Q9H3I8; Q9H5M5; Q9NPX4" "" "Antigen processing: Ubiquitination & Proteasome degradation; RHOBTB1 GTPase cycle" "2" "0" "0.953" "0.984" "1.066" "0.992" "1.177" "1.009" "1.040" "0.973" "0.924" "517.6" "493.6" "509.3" "551.8" "513.5" "609.2" "522.2" "538.2" "503.5" "478.1" "" "" "" "" "" "" "" "" "" "" "465.4" "399.4" "460.7" "538.6" "423.8" "609.2" "391.0" "475.4" "450.6" "170.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1396372760161625634" "False" "High" "IsMasterProtein" "Q8N129" "Protein canopy homolog 4 OS=Homo sapiens OX=9606 GN=CNPY4 PE=1 SV=1" "0.000" "False" "29.587" "31" "6" "8" "6" "248" "28.3" "4.64" "37.20" "6" "other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf11938" "245812" "ENSG00000166997" "CNPY4" "hsa:245812; Q8N129; Q8WUN9" "" "" "0" "0" "0.959" "1.084" "0.960" "0.996" "1.059" "0.960" "0.999" "1.089" "0.852" "748.4" "717.7" "811.5" "718.2" "745.4" "792.5" "718.1" "747.4" "815.1" "637.5" "" "" "" "" "" "" "" "" "" "" "672.9" "580.8" "734.0" "701.0" "615.1" "792.5" "537.7" "660.2" "729.4" "227.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1801369761430289409" "False" "High" "IsMasterProtein" "Q12968" "Nuclear factor of activated T-cells, cytoplasmic 3 OS=Homo sapiens OX=9606 GN=NFATC3 PE=1 SV=1" "0.000" "False" "29.554" "10" "8" "8" "7" "1075" "115.5" "6.37" "31.43" "8" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4775" "ENSG00000072736" "NFATC3" "hsa:4775; O75211; Q12968; Q14516; Q99840; Q99841; Q99842" "Heart development; B cell receptor signaling pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; Wnt signaling; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection" "FCERI mediated Ca+2 mobilization; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "10" "1" "1.013" "1.032" "0.995" "1.020" "1.111" "1.020" "1.002" "1.067" "1.385" "519.2" "525.8" "535.8" "516.9" "529.8" "576.7" "529.4" "520.3" "553.9" "719.1" "" "" "" "" "" "" "" "" "" "" "466.8" "425.4" "484.7" "504.5" "437.2" "576.7" "396.4" "459.5" "495.6" "256.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4065169870199249389" "False" "High" "IsMasterProtein" "Q86VP1" "Tax1-binding protein 1 OS=Homo sapiens OX=9606 GN=TAX1BP1 PE=1 SV=2" "0.000" "False" "29.539" "12" "12" "14" "12" "789" "90.8" "5.43" "44.15" "12" "other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07888, Pf17751, Pf18112" "8887" "ENSG00000106052" "TAX1BP1" "A4D196; B4DKU7; E7ENV2; hsa:8887; O60398; O95770; Q13311; Q86VP1; Q9BQG5; Q9UI88" "" "Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "2" "0" "0.998" "1.039" "0.945" "1.026" "1.041" "0.968" "1.035" "0.967" "1.016" "1389.6" "1387.0" "1443.2" "1312.7" "1425.4" "1446.6" "1345.7" "1438.6" "1344.2" "1412.0" "" "" "" "" "" "" "" "" "" "" "1249.4" "1122.3" "1305.4" "1281.4" "1176.3" "1446.6" "1007.6" "1270.7" "1202.8" "504.0" "10" "10" "10" "10" "10" "10" "10" "10" "10" "10" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1619272264168287387" "False" "High" "IsMasterProtein" "Q8WVT3" "Trafficking protein particle complex subunit 12 OS=Homo sapiens OX=9606 GN=TRAPPC12 PE=1 SV=3" "0.000" "False" "29.472" "15" "9" "9" "9" "735" "79.3" "4.91" "34.76" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf13174, Pf14559" "51112" "ENSG00000171853" "TRAPPC12" "B3KV01; D6W4Y2; hsa:51112; Q8WVT3; Q8WVW1; Q9Y395" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.976" "0.966" "0.954" "0.963" "0.911" "1.021" "0.960" "0.946" "1.117" "966.0" "943.3" "933.3" "921.5" "930.2" "879.9" "986.6" "927.7" "913.5" "1079.3" "" "" "" "" "" "" "" "" "" "" "868.5" "763.3" "844.2" "899.5" "767.7" "879.9" "738.7" "819.4" "817.3" "385.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-651184813655133351" "False" "High" "IsMasterProtein" "P13807" "Glycogen [starch] synthase, muscle OS=Homo sapiens OX=9606 GN=GYS1 PE=1 SV=2" "0.000" "False" "29.453" "14" "8" "9" "8" "737" "83.7" "6.18" "33.22" "8" "other metabolic processes;developmental processes" "cytosol;other cell component" "other molecular function" "Pf05693" "2997" "ENSG00000104812" "GYS1" "hsa:2997; P13807; Q9BTT9" "AMP-activated protein kinase signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Insulin signaling; Glycogen synthesis and degradation; Disorders of galactose metabolism ; 2q37 copy number variation syndrome" "Glycogen synthesis; Myoclonic epilepsy of Lafora; Glycogen storage disease type XV (GYG1); Glycogen storage disease type 0 (muscle GYS1)" "12" "0" "1.028" "0.847" "0.929" "0.945" "0.858" "0.913" "0.945" "0.980" "0.749" "849.3" "872.9" "719.8" "788.8" "802.7" "728.3" "775.5" "802.2" "832.0" "636.0" "" "" "" "" "" "" "" "" "" "" "763.6" "706.3" "651.1" "769.9" "662.4" "728.3" "580.7" "708.5" "744.4" "227.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5117695276373963239" "False" "High" "IsMasterProtein" "Q9UKL0" "REST corepressor 1 OS=Homo sapiens OX=9606 GN=RCOR1 PE=1 SV=2" "0.000" "False" "29.452" "18" "8" "9" "7" "485" "53.3" "7.03" "34.09" "8" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "23186" "ENSG00000089902" "RCOR1" "hsa:23186; J3KN32; Q15044; Q6P2I9; Q86VG5; Q9UKL0" "" "Regulation of PTEN gene transcription; Potential therapeutics for SARS; HDACs deacetylate histones; Factors involved in megakaryocyte development and platelet production" "4" "1" "0.845" "0.791" "0.932" "0.857" "0.751" "0.911" "0.703" "0.750" "1.905" "579.3" "489.7" "458.1" "540.0" "496.6" "435.1" "528.0" "407.3" "434.6" "1103.6" "" "" "" "" "" "" "" "" "" "" "520.8" "396.2" "414.3" "527.1" "409.8" "435.1" "395.3" "359.7" "388.8" "394.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3252394429536465777" "False" "High" "IsMasterProtein" "Q32P41" "tRNA (guanine(37)-N1)-methyltransferase OS=Homo sapiens OX=9606 GN=TRMT5 PE=1 SV=3" "0.000" "False" "29.451" "15" "8" "15" "8" "509" "58.2" "8.62" "41.26" "8" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf02475" "57570" "ENSG00000126814" "TRMT5" "B2RN19; hsa:57570; Q32P41; Q9P2F4" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "0.994" "0.935" "0.963" "1.070" "0.952" "1.053" "0.898" "0.921" "2.218" "909.5" "904.0" "850.0" "876.0" "973.2" "865.5" "957.6" "816.9" "837.9" "2017.2" "" "" "" "" "" "" "" "" "" "" "817.7" "731.5" "768.9" "855.1" "803.1" "865.5" "717.1" "721.5" "749.7" "720.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630996109560083637" "False" "High" "IsMasterProtein" "O75909" "Cyclin-K OS=Homo sapiens OX=9606 GN=CCNK PE=1 SV=2" "0.000" "False" "29.422" "19" "10" "13" "10" "580" "64.2" "8.41" "38.02" "10" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf21797" "8812" "ENSG00000090061" "CCNK" "hsa:8812; O75909; Q59FT6; Q86U16; Q96B63; Q9NNY9" "Male infertility" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "10" "0" "1.070" "1.078" "0.874" "1.074" "1.016" "0.942" "0.954" "0.974" "0.800" "699.1" "748.0" "753.9" "611.3" "750.7" "710.4" "658.9" "666.9" "680.9" "558.9" "" "" "" "" "" "" "" "" "" "" "628.5" "605.2" "681.9" "596.7" "619.5" "710.4" "493.3" "589.1" "609.2" "199.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158651141849584646" "False" "High" "IsMasterProtein" "Q9Y294" "Histone chaperone ASF1A OS=Homo sapiens OX=9606 GN=ASF1A PE=1 SV=1" "0.000" "False" "29.380" "34" "5" "10" "4" "204" "23.0" "4.41" "44.34" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04729" "25842" "ENSG00000111875" "ASF1A" "hsa:25842; Q6IA08; Q9P014; Q9Y294" "22q11.2 copy number variation syndrome" "Formation of Senescence-Associated Heterochromatin Foci (SAHF)" "2" "0" "0.973" "0.927" "1.008" "1.018" "0.940" "0.992" "1.035" "0.969" "0.852" "890.6" "866.7" "825.5" "897.9" "906.4" "837.5" "883.1" "921.5" "862.8" "758.6" "" "" "" "" "" "" "" "" "" "" "800.8" "701.3" "746.7" "876.5" "748.0" "837.5" "661.3" "813.9" "772.0" "270.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3954168667574221268" "False" "High" "IsMasterProtein" "Q9H1J1" "Regulator of nonsense transcripts 3A OS=Homo sapiens OX=9606 GN=UPF3A PE=1 SV=1" "0.000" "False" "29.361" "13" "6" "8" "6" "476" "54.7" "9.03" "29.13" "6" "transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf03467" "65110" "ENSG00000169062" "UPF3A" "A2A366; hsa:65110; Q5T8C3; Q5T8C9; Q7Z6N3; Q86YK1; Q9BZI8; Q9H1J1" "" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "2" "0" "1.001" "1.028" "1.064" "1.093" "1.046" "1.105" "1.047" "1.008" "1.199" "512.2" "512.5" "526.3" "544.8" "559.6" "535.7" "566.2" "536.4" "516.4" "614.4" "" "" "" "" "" "" "" "" "" "" "460.5" "414.7" "476.0" "531.8" "461.8" "535.7" "424.0" "473.8" "462.1" "219.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703778072310238355" "False" "High" "IsMasterProtein" "Q9Y6I3" "Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2" "0.000" "False" "29.360" "18" "7" "10" "7" "576" "60.3" "4.83" "46.36" "7" "transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01417" "29924" "ENSG00000063245" "EPN1" "hsa:29924; Q86ST3; Q9HA18; Q9Y6I3" "VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway" "Cargo recognition for clathrin-mediated endocytosis; EGFR downregulation" "5" "0" "0.915" "1.044" "1.007" "0.992" "1.194" "0.994" "1.030" "0.959" "1.022" "406.0" "371.4" "424.0" "408.7" "402.6" "484.6" "403.4" "418.3" "389.4" "414.9" "" "" "" "" "" "" "" "" "" "" "365.0" "300.5" "383.6" "398.9" "332.2" "484.6" "302.0" "369.5" "348.4" "148.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2783720911668015522" "False" "High" "IsMasterProtein" "Q9NWT6" "Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens OX=9606 GN=HIF1AN PE=1 SV=2" "0.000" "False" "29.356" "23" "8" "10" "8" "349" "40.3" "5.57" "40.23" "8" "other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13621" "55662" "ENSG00000166135" "HIF1AN" "D3DR69; hsa:55662; Q5W147; Q969Q7; Q9NPV5; Q9NWT6" "MicroRNA for targeting cancer growth and vascularization in glioblastoma; Photodynamic therapy-induced HIF-1 survival signaling" "Cellular response to hypoxia" "3" "0" "0.980" "0.975" "0.992" "1.063" "0.982" "0.959" "1.005" "1.020" "0.910" "1552.1" "1521.0" "1514.0" "1539.1" "1649.8" "1524.7" "1488.3" "1560.4" "1583.1" "1412.7" "" "" "" "" "" "" "" "" "" "" "1395.5" "1230.7" "1369.5" "1502.4" "1361.5" "1524.7" "1114.4" "1378.3" "1416.5" "504.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-411341991637906360" "False" "High" "IsMasterProtein" "P27448" "MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens OX=9606 GN=MARK3 PE=1 SV=5" "0.000" "False" "29.350" "10" "7" "11" "4" "753" "84.4" "9.57" "31.05" "7" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "4140" "ENSG00000075413" "MARK3" "A0A0A0MQR8; A0A0A0MST9; A0A0A0MT23; hsa:4140; O60219; P27448; Q86TT8; Q8TB41; Q8WX83; Q96RG1; Q9UMY9; Q9UN34" "Complement system in neuronal development and plasticity" "Signaling by BRAF and RAF1 fusions; RAF activation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants" "10" "2" "0.980" "1.040" "1.039" "1.049" "1.102" "1.095" "0.955" "1.033" "1.216" "433.9" "425.3" "451.4" "450.7" "455.3" "478.1" "475.3" "414.6" "448.1" "527.6" "" "" "" "" "" "" "" "" "" "" "390.1" "344.1" "408.3" "440.0" "375.7" "478.1" "355.9" "366.2" "400.9" "188.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3867715510256549408" "False" "High" "IsMasterProtein" "P49757" "Protein numb homolog OS=Homo sapiens OX=9606 GN=NUMB PE=1 SV=2" "0.000" "False" "29.330" "16" "8" "9" "8" "651" "70.8" "8.51" "34.47" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00640, Pf06311" "8650" "ENSG00000133961" "NUMB" "B1P2N5; B1P2N6; B1P2N7; B1P2N8; B1P2N9; B4E2B1; hsa:8650; P49757; Q6NUQ7; Q86SY1; Q8WW73; Q9UBG1; Q9UEQ4; Q9UKE8; Q9UKE9; Q9UKF0; Q9UQJ4" "Notch signaling; VEGFA-VEGFR2 signaling; Head and neck squamous cell carcinoma; Neurogenesis regulation in the olfactory epithelium; TROP2 regulatory signaling; Notch signaling pathway" "Recycling pathway of L1; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus" "10" "0" "1.015" "1.022" "0.937" "0.994" "1.020" "0.950" "0.999" "0.918" "0.868" "578.2" "586.9" "590.9" "541.8" "574.6" "589.8" "549.3" "577.7" "531.0" "501.8" "" "" "" "" "" "" "" "" "" "" "519.9" "474.9" "534.5" "528.9" "474.2" "589.8" "411.3" "510.3" "475.1" "179.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119829718007226858" "False" "High" "IsMasterProtein" "Q9UJX5" "Anaphase-promoting complex subunit 4 OS=Homo sapiens OX=9606 GN=ANAPC4 PE=1 SV=2" "0.000" "False" "29.318" "12" "8" "8" "8" "808" "92.1" "5.53" "32.44" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12894, Pf12896" "29945" "ENSG00000053900" "ANAPC4" "A8K8H1; E9PCR4; hsa:29945; Q6PCC6; Q9NSH6; Q9UJX5" "Cell cycle" "Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.068" "1.038" "0.919" "1.086" "0.993" "0.967" "0.957" "1.073" "0.936" "397.9" "425.2" "412.9" "365.5" "432.3" "395.3" "384.8" "380.7" "427.1" "372.5" "" "" "" "" "" "" "" "" "" "" "357.8" "344.0" "373.5" "356.8" "356.7" "395.3" "288.1" "336.3" "382.1" "133.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8467787264096672406" "False" "High" "IsMasterProtein" "O00506" "Serine/threonine-protein kinase 25 OS=Homo sapiens OX=9606 GN=STK25 PE=1 SV=1" "0.000" "False" "29.299" "13" "5" "14" "1" "426" "48.1" "6.74" "48.92" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf20929" "10494" "ENSG00000115694" "STK25" "A8K6Z3; A8K7D2; B7Z9K1; hsa:10494; O00506; Q15522; Q5BJF1" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5166856508772248001" "False" "High" "IsMasterProtein" "P01111" "GTPase NRas OS=Homo sapiens OX=9606 GN=NRAS PE=1 SV=1" "0.000" "False" "29.286" "41" "6" "9" "6" "189" "21.2" "5.17" "37.37" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00071" "4893" "ENSG00000213281" "NRAS" "hsa:4893; P01111; Q14971; Q15104; Q15282" "Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; RalA downstream regulated genes; TNF-alpha signaling pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; Extracellular vesicle-mediated signaling in recipient cells; RAC1/PAK1/p38/MMP2 pathway; G protein signaling pathways; BDNF-TrkB signaling; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Non-small cell lung cancer; Breast cancer pathway; Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Relationship between inflammation, COX-2 and EGFR; Envelope proteins and their potential roles in EDMD physiopathology; Synaptic signaling pathways associated with autism spectrum disorder; Hippo-Merlin signaling dysregulation; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; EGFR tyrosine kinase inhibitor resistance; Kisspeptin/kisspeptin receptor system in the ovary; CCL18 signaling pathway; Regulation of actin cytoskeleton; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; JAK-STAT signaling in the regulation of beta cells; ErbB signaling pathway; DNA damage response (only ATM dependent); Serotonin receptor 2 and ELK-SRF/GATA4 signaling" "FCERI mediated MAPK activation; Neutrophil degranulation; Regulation of RAS by GAPs; Signaling by BRAF and RAF1 fusions; Signaling by SCF-KIT; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; RAF activation; Ras activation upon Ca2+ influx through NMDA receptor; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; p38MAPK events; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; RAS processing; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Erythropoietin activates RAS; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; CD209 (DC-SIGN) signaling; Activation of RAS in B cells; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MAP2K and MAPK activation; Negative regulation of MAPK pathway; Signaling by high-kinase activity BRAF mutants; RAS signaling downstream of NF1 loss-of-function variants; Insulin receptor signalling cascade; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signaling by RAS GAP mutants; Signaling by RAS GTPase mutants" "110" "0" "0.869" "0.915" "1.029" "0.898" "0.886" "0.907" "0.933" "0.954" "0.717" "932.9" "810.9" "853.2" "959.8" "837.9" "826.5" "846.6" "870.7" "890.4" "668.7" "" "" "" "" "" "" "" "" "" "" "838.8" "656.1" "771.7" "936.9" "691.4" "826.5" "633.9" "769.0" "796.7" "238.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3951454542439150493" "False" "High" "IsMasterProtein" "Q9HB40" "Retinoid-inducible serine carboxypeptidase OS=Homo sapiens OX=9606 GN=SCPEP1 PE=1 SV=1" "0.000" "False" "29.275" "13" "7" "11" "7" "452" "50.8" "5.81" "42.17" "7" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00450" "59342" "ENSG00000121064" "SCPEP1" "hsa:59342; Q96A94; Q9H3F0; Q9HB40" "" "" "0" "0" "0.950" "0.989" "0.972" "0.981" "0.950" "0.927" "0.989" "0.984" "0.811" "1347.7" "1280.1" "1333.0" "1310.2" "1321.8" "1279.7" "1249.2" "1332.8" "1326.8" "1093.3" "" "" "" "" "" "" "" "" "" "" "1211.7" "1035.8" "1205.8" "1278.9" "1090.8" "1279.7" "935.4" "1177.2" "1187.2" "390.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5802267777781672264" "False" "High" "IsMasterProtein" "O43665" "Regulator of G-protein signaling 10 OS=Homo sapiens OX=9606 GN=RGS10 PE=1 SV=3" "0.000" "False" "29.269" "28" "4" "11" "4" "181" "21.2" "7.49" "40.12" "4" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "6001" "ENSG00000148908" "RGS10" "A8K408; B1AMR8; hsa:6001; O43665; Q6IAZ6; Q96GN0" "Mesodermal commitment pathway; Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (i) signalling events" "4" "0" "0.929" "0.925" "0.900" "0.982" "0.969" "0.980" "0.985" "0.997" "0.901" "1029.4" "956.3" "952.0" "926.5" "1010.7" "997.2" "1008.3" "1013.5" "1026.1" "927.9" "" "" "" "" "" "" "" "" "" "" "925.5" "773.8" "861.1" "904.4" "834.0" "997.2" "755.0" "895.2" "918.2" "331.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1831156275587946455" "False" "High" "IsMasterProtein" "Q7Z401" "C-myc promoter-binding protein OS=Homo sapiens OX=9606 GN=DENND4A PE=1 SV=2" "0.000" "False" "29.223" "7" "8" "10" "8" "1863" "209.1" "7.31" "33.88" "8" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf02141, Pf03455, Pf03456" "10260" "ENSG00000174485" "DENND4A" "E7EPL3; hsa:10260; Q14655; Q7Z401; Q86T77; Q8IVX2; Q8NB93" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.863" "0.842" "0.941" "0.875" "0.851" "0.892" "0.836" "0.899" "2.003" "233.4" "201.5" "196.6" "219.6" "204.3" "198.6" "208.2" "195.2" "209.8" "467.6" "" "" "" "" "" "" "" "" "" "" "209.9" "163.0" "177.8" "214.4" "168.6" "198.6" "155.9" "172.4" "187.7" "166.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400550207963658767" "False" "High" "IsMasterProtein" "Q8WWY3" "U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens OX=9606 GN=PRPF31 PE=1 SV=2" "0.000" "False" "29.195" "19" "8" "9" "8" "499" "55.4" "5.78" "35.51" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01798, Pf09785" "26121" "ENSG00000105618; ENSG00000274144; ENSG00000274651; ENSG00000274894; ENSG00000275117; ENSG00000275885; ENSG00000276421; ENSG00000277154; ENSG00000277707; ENSG00000277953" "PRPF31" "E7ESA8; F1T0A4; F1T0A5; hsa:26121; Q17RB4; Q8N7F9; Q8WWY3; Q9H271; Q9Y439" "" "mRNA Splicing - Major Pathway" "1" "0" "1.020" "0.858" "1.074" "0.894" "0.851" "1.109" "0.941" "0.912" "2.844" "386.8" "394.6" "331.8" "415.5" "345.8" "329.0" "428.8" "364.2" "352.7" "1100.0" "" "" "" "" "" "" "" "" "" "" "347.8" "319.3" "300.2" "405.6" "285.3" "329.0" "321.1" "321.7" "315.6" "392.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2503112779916804665" "False" "High" "IsMasterProtein" "Q8WV28" "B-cell linker protein OS=Homo sapiens OX=9606 GN=BLNK PE=1 SV=2" "0.000" "False" "29.193" "21" "10" "19" "10" "456" "50.4" "8.16" "52.46" "10" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017" "29760" "ENSG00000095585" "BLNK" "hsa:29760; O75498; O75499; Q2MD49; Q8WV28" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Potential therapeutics for SARS; Regulation of signaling by CBL; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "5" "0" "0.928" "0.924" "0.892" "0.993" "0.950" "0.984" "1.001" "0.899" "0.789" "1223.8" "1135.9" "1130.4" "1092.2" "1215.6" "1162.8" "1204.7" "1225.3" "1100.1" "965.8" "" "" "" "" "" "" "" "" "" "" "1100.3" "919.2" "1022.5" "1066.1" "1003.1" "1162.8" "902.1" "1082.3" "984.4" "344.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3231455898363948540" "False" "High" "IsMasterProtein" "Q15833" "Syntaxin-binding protein 2 OS=Homo sapiens OX=9606 GN=STXBP2 PE=1 SV=2" "0.000" "False" "29.152" "13" "7" "10" "7" "593" "66.4" "6.55" "36.07" "7" "cell-cell signaling;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "6813" "ENSG00000076944" "STXBP2" "B4E175; E7EQD5; hsa:6813; Q15833; Q9BU65" "Splicing factor NOVA regulated synaptic proteins; Insulin signaling" "Platelet degranulation ; Other interleukin signaling" "4" "0" "0.923" "0.952" "0.946" "0.876" "0.884" "1.011" "0.765" "0.871" "4.377" "677.7" "625.3" "645.0" "641.2" "593.8" "598.9" "685.1" "518.2" "590.1" "2965.9" "" "" "" "" "" "" "" "" "" "" "609.3" "505.9" "583.4" "625.9" "490.0" "598.9" "513.0" "457.7" "528.0" "1058.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703372283530206058" "False" "High" "IsMasterProtein" "Q9NP97" "Dynein light chain roadblock-type 1 OS=Homo sapiens OX=9606 GN=DYNLRB1 PE=1 SV=3" "0.000" "False" "29.142" "40" "3" "12" "3" "96" "10.9" "7.25" "52.22" "3" "other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf03259" "83658" "ENSG00000125971" "DYNLRB1" "B1AKR5; hsa:83658; Q5TC72; Q96IV3; Q9NP97; Q9NQM2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome" "Intraflagellar transport" "4" "0" "0.875" "0.963" "0.920" "0.969" "0.989" "0.914" "1.009" "1.010" "0.729" "1966.7" "1720.9" "1894.3" "1809.6" "1905.4" "1944.5" "1797.3" "1985.3" "1986.5" "1434.4" "" "" "" "" "" "" "" "" "" "" "1768.3" "1392.5" "1713.4" "1766.5" "1572.3" "1944.5" "1345.8" "1753.5" "1777.5" "512.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3786369172385558853" "False" "High" "IsMasterProtein" "P19388" "DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Homo sapiens OX=9606 GN=POLR2E PE=1 SV=4" "0.000" "False" "29.102" "36" "7" "14" "7" "210" "24.5" "5.95" "32.29" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01191, Pf03871" "5434" "ENSG00000099817" "POLR2E" "B2R6L4; D6W5Y1; hsa:5434; O43380; P19388; Q6PIH5; Q9BT06" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "0.959" "0.918" "0.945" "1.040" "0.956" "1.017" "0.945" "0.966" "3.631" "582.0" "558.2" "534.4" "549.7" "605.3" "556.1" "592.0" "550.1" "562.0" "2112.9" "" "" "" "" "" "" "" "" "" "" "523.2" "451.7" "483.4" "536.6" "499.5" "556.1" "443.3" "485.9" "502.9" "754.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-273580326344755001" "False" "High" "IsMasterProtein" "P26885" "Peptidyl-prolyl cis-trans isomerase FKBP2 OS=Homo sapiens OX=9606 GN=FKBP2 PE=1 SV=2" "0.000" "False" "29.042" "37" "5" "10" "5" "142" "15.6" "9.13" "36.78" "5" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00254" "2286" "ENSG00000173486" "FKBP2" "hsa:2286; P26885; Q5BJH9; Q9BTS7" "Complement system" "" "1" "0" "0.927" "0.939" "1.016" "1.036" "0.988" "1.022" "1.052" "1.038" "0.863" "1131.4" "1048.7" "1062.5" "1149.5" "1172.0" "1117.8" "1155.9" "1190.7" "1174.9" "976.0" "" "" "" "" "" "" "" "" "" "" "1017.2" "848.6" "961.0" "1122.1" "967.1" "1117.8" "865.5" "1051.7" "1051.3" "348.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8095037981369694658" "False" "High" "IsMasterProtein" "P52434" "DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens OX=9606 GN=POLR2H PE=1 SV=4" "0.000" "False" "29.036" "49" "5" "10" "5" "150" "17.1" "4.68" "44.69" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03870" "5437" "ENSG00000163882" "POLR2H" "C9J413; C9JBJ6; C9JCU7; C9JUA8; hsa:5437; P52434; P53802; Q969R0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA polymerase II transcribes snRNA genes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "0.994" "1.050" "0.946" "0.976" "0.965" "0.957" "0.978" "0.990" "1.373" "774.6" "770.1" "813.2" "732.5" "756.3" "747.5" "741.5" "757.9" "766.6" "1063.8" "" "" "" "" "" "" "" "" "" "" "696.4" "623.1" "735.6" "715.0" "624.1" "747.5" "555.2" "669.4" "685.9" "379.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1721155162359169472" "False" "High" "IsMasterProtein" "Q9UBQ0" "Vacuolar protein sorting-associated protein 29 OS=Homo sapiens OX=9606 GN=VPS29 PE=1 SV=1" "0.000" "False" "29.034" "45" "8" "15" "8" "182" "20.5" "6.79" "48.12" "8" "transport" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf12850" "51699" "ENSG00000111237" "VPS29" "hsa:51699; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7; Q9UBQ0" "" "WNT ligand biogenesis and trafficking" "1" "0" "0.957" "0.949" "1.001" "0.942" "0.960" "0.903" "0.953" "0.976" "0.766" "1531.1" "1465.5" "1452.3" "1532.7" "1441.9" "1470.2" "1383.2" "1459.1" "1494.2" "1172.1" "" "" "" "" "" "" "" "" "" "" "1376.6" "1185.8" "1313.6" "1496.1" "1189.9" "1470.2" "1035.7" "1288.8" "1337.0" "418.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2891424664368030590" "False" "High" "IsMasterProtein" "Q8N6T3" "ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens OX=9606 GN=ARFGAP1 PE=1 SV=2" "0.000" "False" "29.034" "25" "7" "10" "7" "406" "44.6" "5.66" "33.75" "7" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "55738" "ENSG00000101199" "ARFGAP1" "B7Z3U0; B7Z8H8; B7ZBI3; E1P5I9; E7EV62; hsa:55738; Q6PK71; Q8N6T3; Q96KC4; Q96T02; Q9NSU3; Q9NVF6; Q9UIL0" "IL-18 signaling pathway" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Clathrin-mediated endocytosis; XBP1(S) activates chaperone genes" "5" "0" "1.132" "1.056" "1.026" "1.049" "1.052" "1.083" "1.040" "1.098" "0.983" "657.9" "744.6" "695.0" "675.2" "690.1" "692.1" "712.6" "684.5" "722.4" "646.4" "" "" "" "" "" "" "" "" "" "" "591.5" "602.5" "628.6" "659.1" "569.5" "692.1" "533.6" "604.6" "646.4" "230.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4773428691670053213" "False" "High" "IsMasterProtein" "P62834" "Ras-related protein Rap-1A OS=Homo sapiens OX=9606 GN=RAP1A PE=1 SV=1" "0.000" "False" "29.034" "38" "6" "12" "2" "184" "21.0" "6.67" "38.48" "6" "cell-cell signaling;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00071" "5906" "ENSG00000116473" "RAP1A" "hsa:5906; P10113; P62834" "Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Common pathways underlying drug addiction; Focal adhesion; Hepatocyte growth factor receptor signaling; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; DNA repair pathways, full network; GDNF signaling; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Neutrophil degranulation; Signaling by BRAF and RAF1 fusions; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Rap1 signalling; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; Frs2-mediated activation; ARMS-mediated activation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; MET activates RAP1 and RAC1" "35" "0" "0.781" "0.870" "0.980" "0.989" "0.826" "0.909" "0.932" "1.074" "0.895" "176.2" "137.5" "153.3" "172.6" "174.3" "145.5" "160.2" "164.3" "189.2" "157.6" "" "" "" "" "" "" "" "" "" "" "158.4" "111.3" "138.7" "168.5" "143.8" "145.5" "120.0" "145.1" "169.3" "56.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991774416485678648" "False" "High" "IsMasterProtein" "P51948" "CDK-activating kinase assembly factor MAT1 OS=Homo sapiens OX=9606 GN=MNAT1 PE=1 SV=1" "0.000" "False" "29.006" "20" "6" "10" "6" "309" "35.8" "6.09" "39.96" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus" "enzyme regulator activity;other molecular function" "Pf06391, Pf17121" "4331" "ENSG00000020426" "MNAT1" "G3V1U8; hsa:4331; P51948; Q15817; Q6ICQ7" "Eukaryotic transcription initiation; G1 to S cell cycle control; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; RUNX1 regulates transcription of genes involved in differentiation of HSCs; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Cyclin D associated events in G1; Cyclin A/B1/B2 associated events during G2/M transition; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Cyclin E associated events during G1/S transition ; Cyclin A:Cdk2-associated events at S phase entry" "38" "0" "0.999" "0.984" "0.959" "0.990" "1.060" "1.025" "1.005" "1.071" "0.860" "448.8" "448.3" "441.5" "430.5" "444.2" "475.9" "460.2" "451.3" "480.6" "385.8" "" "" "" "" "" "" "" "" "" "" "403.5" "362.7" "399.3" "420.2" "366.5" "475.9" "344.6" "398.6" "430.1" "137.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8285905538601848760" "False" "High" "IsMasterProtein" "Q9H0E9" "Bromodomain-containing protein 8 OS=Homo sapiens OX=9606 GN=BRD8 PE=1 SV=2" "0.000" "False" "28.936" "6" "6" "8" "6" "1235" "135.3" "4.60" "30.00" "6" "cell organization and biogenesis;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00439" "10902" "ENSG00000112983" "BRD8" "hsa:10902; O43178; Q15355; Q58AB0; Q59GN0; Q969M9; Q9H0E9" "" "HATs acetylate histones" "1" "0" "1.001" "1.019" "0.964" "1.002" "0.951" "1.020" "1.036" "1.007" "0.983" "524.5" "525.2" "534.5" "505.8" "525.4" "498.8" "534.8" "543.2" "528.1" "515.3" "" "" "" "" "" "" "" "" "" "" "471.6" "425.0" "483.5" "493.8" "433.6" "498.8" "400.4" "479.8" "472.5" "184.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7756363839167913105" "False" "High" "IsMasterProtein" "Q13490" "Baculoviral IAP repeat-containing protein 2 OS=Homo sapiens OX=9606 GN=BIRC2 PE=1 SV=2" "0.000" "False" "28.904" "13" "8" "10" "8" "618" "69.9" "6.70" "36.43" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00653, Pf13920, Pf21290" "329" "ENSG00000110330" "BIRC2" "B4E026; hsa:329; Q13490; Q16516; Q4TTG0" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Apoptosis; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Focal adhesion; Photodynamic therapy-induced NF-kB survival signaling; Small cell lung cancer; Gastrin signaling pathway; Head and neck squamous cell carcinoma" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKK complex recruitment mediated by RIP1; Regulation of necroptotic cell death; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TNFR1-induced proapoptotic signaling; Apoptotic cleavage of cellular proteins" "22" "0" "1.015" "0.921" "0.991" "0.992" "0.906" "1.011" "1.016" "0.894" "0.969" "1158.2" "1176.0" "1066.6" "1148.1" "1148.7" "1049.7" "1170.4" "1176.7" "1035.6" "1122.7" "" "" "" "" "" "" "" "" "" "" "1041.3" "951.6" "964.8" "1120.7" "947.9" "1049.7" "876.4" "1039.4" "926.6" "400.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7029277553794243506" "False" "High" "IsMasterProtein" "P61244" "Protein max OS=Homo sapiens OX=9606 GN=MAX PE=1 SV=1" "0.000" "False" "28.843" "53" "7" "10" "7" "160" "18.3" "6.30" "39.23" "7" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4149" "ENSG00000125952" "MAX" "A6NH73; A8K265; A8K4G4; A8K824; hsa:4149; P25912; P52163; P61244; Q14803; Q96CY8" "B cell receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; MAPK signaling pathway; p38 MAPK signaling pathway; Small cell lung cancer; Pleural mesothelioma; 5q35 copy number variation" "Transcriptional Regulation by E2F6; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry" "11" "0" "0.971" "1.051" "0.921" "0.974" "1.044" "0.867" "0.956" "1.006" "0.879" "744.6" "723.2" "782.7" "685.7" "724.9" "777.4" "645.5" "711.5" "749.1" "654.3" "" "" "" "" "" "" "" "" "" "" "669.5" "585.2" "708.0" "669.4" "598.2" "777.4" "483.4" "628.4" "670.3" "233.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2136811018986940550" "False" "High" "IsMasterProtein" "Q9NS91" "E3 ubiquitin-protein ligase RAD18 OS=Homo sapiens OX=9606 GN=RAD18 PE=1 SV=2" "0.000" "False" "28.806" "20" "10" "11" "10" "495" "56.2" "7.58" "36.53" "10" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02037, Pf13923" "56852" "ENSG00000070950" "RAD18" "Q58F55; Q9NRT6; Q9NS91" "SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome" "Recognition of DNA damage by PCNA-containing replication complex; E3 ubiquitin ligases ubiquitinate target proteins" "3" "0" "1.034" "1.169" "0.969" "1.062" "1.147" "1.036" "1.031" "1.109" "1.994" "520.8" "538.7" "609.1" "504.5" "553.0" "597.2" "539.7" "537.2" "577.9" "1038.7" "" "" "" "" "" "" "" "" "" "" "468.3" "435.9" "551.0" "492.5" "456.3" "597.2" "404.1" "474.5" "517.1" "370.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1492167490634941437" "False" "High" "IsMasterProtein" "P49914" "5-formyltetrahydrofolate cyclo-ligase OS=Homo sapiens OX=9606 GN=MTHFS PE=1 SV=2" "0.000" "False" "28.763" "39" "7" "10" "7" "203" "23.2" "7.88" "27.96" "7" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01812" "10588" "ENSG00000136371" "MTHFS" "H3BQ75; hsa:10588; P49914" "Folate metabolism; One-carbon metabolism; Disorders of folate metabolism and transport" "Metabolism of folate and pterines" "4" "0" "0.953" "0.965" "1.003" "0.984" "0.922" "0.935" "1.059" "1.023" "0.901" "688.8" "656.6" "664.7" "690.9" "677.6" "634.9" "644.2" "729.2" "704.3" "620.9" "" "" "" "" "" "" "" "" "" "" "619.3" "531.3" "601.3" "674.4" "559.2" "634.9" "482.4" "644.1" "630.2" "221.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4293780430971367314" "False" "High" "IsMasterProtein" "Q13371" "Phosducin-like protein OS=Homo sapiens OX=9606 GN=PDCL PE=1 SV=3" "0.000" "False" "28.761" "28" "7" "10" "7" "301" "34.3" "4.73" "34.40" "7" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf02114" "5082" "ENSG00000136940" "PDCL" "hsa:5082; Q13371; Q4VXB6; Q96AF1; Q9UEW7; Q9UFL0; Q9UNX1; Q9UNX2" "" "Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding" "1" "0" "0.923" "1.050" "1.002" "1.053" "0.993" "0.949" "1.020" "1.056" "0.891" "365.8" "337.6" "384.1" "366.7" "385.1" "363.4" "347.2" "373.2" "386.5" "326.0" "" "" "" "" "" "" "" "" "" "" "328.9" "273.2" "347.4" "358.0" "317.8" "363.4" "259.9" "329.7" "345.8" "116.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5495353831656127209" "False" "High" "IsMasterProtein" "Q8ND04" "Nonsense-mediated mRNA decay factor SMG8 OS=Homo sapiens OX=9606 GN=SMG8 PE=1 SV=1" "0.000" "False" "28.760" "10" "8" "11" "8" "991" "109.6" "7.68" "33.96" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol" "" "Pf10220" "55181" "ENSG00000167447" "SMG8" "hsa:55181; Q8N5U5; Q8ND04; Q8TDN0; Q9H5P5; Q9NVQ1" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "1.035" "1.053" "1.014" "1.023" "1.087" "0.989" "1.094" "1.008" "1.515" "339.7" "351.4" "357.6" "344.4" "347.4" "369.3" "335.9" "371.8" "342.3" "514.7" "" "" "" "" "" "" "" "" "" "" "305.4" "284.4" "323.5" "336.2" "286.7" "369.3" "251.5" "328.4" "306.3" "183.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8122664404387137367" "False" "High" "IsMasterProtein" "Q96JP5" "E3 ubiquitin-protein ligase ZFP91 OS=Homo sapiens OX=9606 GN=ZFP91 PE=1 SV=1" "0.000" "False" "28.750" "17" "9" "10" "9" "570" "63.4" "7.36" "36.73" "9" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00096" "80829" "ENSG00000186660" "ZFP91" "A6NHC4; A8MSG7; Q86V47; Q96JP4; Q96JP5; Q96QA3" "" "" "0" "0" "0.969" "0.900" "0.877" "0.913" "0.913" "0.955" "0.919" "0.910" "0.858" "795.0" "770.1" "715.7" "697.4" "725.9" "726.0" "759.3" "731.0" "723.4" "681.9" "" "" "" "" "" "" "" "" "" "" "714.8" "623.1" "647.4" "680.7" "599.1" "726.0" "568.6" "645.6" "647.3" "243.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5788074156748143009" "False" "High" "IsMasterProtein" "Q96IJ6" "Mannose-1-phosphate guanyltransferase alpha OS=Homo sapiens OX=9606 GN=GMPPA PE=1 SV=1" "0.000" "False" "28.750" "20" "7" "9" "7" "420" "46.3" "7.21" "35.25" "7" "other metabolic processes" "other cell component" "other molecular function" "Pf00132, Pf00483" "29926" "ENSG00000144591" "GMPPA" "A6NJ74; A8K3Q6; B3KMT4; hsa:29926; Q53GI0; Q96IJ6; Q9NWC3; Q9Y5P5" "N-glycan biosynthesis" "Synthesis of GDP-mannose" "2" "0" "1.125" "1.008" "0.940" "1.128" "1.130" "1.059" "1.038" "1.063" "0.798" "463.8" "521.6" "467.5" "436.2" "523.1" "524.2" "491.2" "481.6" "492.8" "369.9" "" "" "" "" "" "" "" "" "" "" "417.0" "422.0" "422.9" "425.8" "431.7" "524.2" "367.8" "425.4" "441.0" "132.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4335544546222164902" "False" "High" "IsMasterProtein" "Q9NRX4" "14 kDa phosphohistidine phosphatase OS=Homo sapiens OX=9606 GN=PHPT1 PE=1 SV=1" "0.000" "False" "28.722" "59" "6" "10" "6" "125" "13.8" "6.07" "33.88" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05005" "29085" "ENSG00000054148" "PHPT1" "B1AMX0; B1AMX1; hsa:29085; Q9H0Y3; Q9NRX4" "" "" "0" "0" "1.187" "1.069" "1.145" "1.140" "1.084" "1.112" "1.334" "1.241" "0.846" "478.9" "568.7" "511.9" "548.2" "545.8" "519.1" "532.8" "639.0" "594.3" "405.3" "" "" "" "" "" "" "" "" "" "" "430.6" "460.2" "463.0" "535.1" "450.4" "519.1" "398.9" "564.4" "531.8" "144.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "222321955828462706" "False" "High" "IsMasterProtein" "O00244" "Copper transport protein ATOX1 OS=Homo sapiens OX=9606 GN=ATOX1 PE=1 SV=1" "0.000" "False" "28.697" "75" "4" "16" "4" "68" "7.4" "7.24" "73.41" "4" "stress response;transport;other biological processes" "cytosol" "other molecular function" "Pf00403" "475" "ENSG00000177556" "ATOX1" "A8KAJ8; D3DQI2; hsa:475; O00244; Q2M1R6; Q56AP3" "Copper homeostasis" "Detoxification of Reactive Oxygen Species; Ion influx/efflux at host-pathogen interface" "3" "0" "0.898" "0.972" "1.014" "0.952" "1.020" "1.047" "0.982" "0.978" "0.747" "1825.2" "1638.6" "1774.2" "1850.5" "1738.4" "1861.9" "1910.9" "1792.8" "1784.7" "1363.7" "" "" "" "" "" "" "" "" "" "" "1641.0" "1325.9" "1604.8" "1806.3" "1434.5" "1861.9" "1430.9" "1583.5" "1597.0" "486.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9218003044822153883" "False" "High" "IsMasterProtein" "O95881" "Thioredoxin domain-containing protein 12 OS=Homo sapiens OX=9606 GN=TXNDC12 PE=1 SV=1" "0.000" "False" "28.696" "31" "5" "13" "5" "172" "19.2" "5.40" "43.66" "5" "other biological processes" "ER/Golgi" "other molecular function" "Pf13899" "51060" "ENSG00000117862" "TXNDC12" "B3KQS0; hsa:51060; O95881; Q5T1T4; Q96H50" "" "" "0" "0" "0.992" "0.946" "0.953" "0.960" "0.919" "1.093" "0.983" "0.947" "0.951" "841.2" "834.4" "795.4" "801.9" "807.6" "773.0" "919.0" "826.5" "796.6" "799.9" "" "" "" "" "" "" "" "" "" "" "756.3" "675.1" "719.4" "782.8" "666.4" "773.0" "688.1" "730.0" "712.8" "285.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545176652009721876" "False" "High" "IsMasterProtein" "Q9P013" "Spliceosome-associated protein CWC15 homolog OS=Homo sapiens OX=9606 GN=CWC15 PE=1 SV=2" "0.000" "False" "28.666" "36" "8" "13" "8" "229" "26.6" "5.71" "36.09" "8" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf04889" "51503" "ENSG00000150316" "CWC15" "B2RC17; hsa:51503; Q05BV9; Q05DM1; Q9P013; Q9UI29" "" "mRNA Splicing - Major Pathway" "1" "0" "1.006" "0.912" "0.940" "0.895" "1.037" "0.910" "0.999" "0.895" "0.642" "1384.3" "1392.8" "1262.9" "1301.1" "1238.9" "1435.8" "1259.2" "1382.4" "1239.5" "888.8" "" "" "" "" "" "" "" "" "" "" "1244.7" "1127.0" "1142.3" "1270.1" "1022.4" "1435.8" "942.9" "1221.0" "1109.1" "317.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5993686438301718268" "False" "High" "IsMasterProtein" "Q96P11" "28S rRNA (cytosine-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NSUN5 PE=1 SV=2" "0.000" "False" "28.663" "20" "7" "8" "7" "429" "46.7" "8.62" "29.34" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf21148, Pf21153" "55695" "ENSG00000130305" "NSUN5" "B3KX04; B4DP79; G3V0G9; hsa:55695; Q6ZUI8; Q96HT9; Q96P11; Q9NW70" "" "" "0" "0" "1.025" "0.870" "0.920" "1.079" "0.961" "1.074" "0.909" "0.937" "2.492" "372.8" "382.0" "324.2" "343.1" "402.1" "358.3" "400.5" "339.0" "349.4" "928.9" "" "" "" "" "" "" "" "" "" "" "335.2" "309.1" "293.3" "334.9" "331.8" "358.3" "299.9" "299.4" "312.6" "331.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049018417817342026" "False" "High" "IsMasterProtein" "P09497" "Clathrin light chain B OS=Homo sapiens OX=9606 GN=CLTB PE=1 SV=1" "0.000" "False" "28.662" "26" "7" "12" "7" "229" "25.2" "4.64" "43.27" "7" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01086" "1212" "ENSG00000175416" "CLTB" "hsa:1212; P09497; Q53Y37; Q6FHW1" "Ebola virus infection in host; Fragile X syndrome; 5q35 copy number variation" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; Formation of annular gap junctions" "11" "0" "0.937" "0.998" "0.927" "0.951" "0.992" "0.998" "0.997" "0.965" "0.711" "1944.3" "1821.3" "1940.5" "1802.3" "1848.0" "1928.5" "1939.8" "1937.6" "1876.3" "1382.4" "" "" "" "" "" "" "" "" "" "" "1748.1" "1473.8" "1755.2" "1759.3" "1525.0" "1928.5" "1452.4" "1711.4" "1678.9" "493.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2420827179212213562" "False" "High" "IsMasterProtein" "P30622" "CAP-Gly domain-containing linker protein 1 OS=Homo sapiens OX=9606 GN=CLIP1 PE=1 SV=2" "0.000" "False" "28.639" "8" "10" "12" "9" "1438" "162.1" "5.36" "39.60" "10" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf16641" "6249" "ENSG00000130779" "CLIP1" "A0AVD3; hsa:6249; P30622; Q17RS4; Q29RG0" "Microtubule cytoskeleton regulation; PAFAH1B1 copy number variation" "RHO GTPases Activate Formins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases activate IQGAPs; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "1" "0.993" "0.951" "0.967" "1.026" "0.918" "0.975" "0.989" "0.948" "0.871" "864.1" "857.7" "821.8" "835.6" "886.4" "793.5" "842.6" "854.2" "818.9" "753.0" "" "" "" "" "" "" "" "" "" "" "776.9" "694.1" "743.3" "815.6" "731.5" "793.5" "630.9" "754.5" "732.7" "268.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "978357741075337008" "False" "High" "IsMasterProtein" "Q6UN15" "Pre-mRNA 3'-end-processing factor FIP1 OS=Homo sapiens OX=9606 GN=FIP1L1 PE=1 SV=1" "0.000" "False" "28.629" "15" "7" "10" "7" "594" "66.5" "5.59" "26.90" "7" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf05182" "81608" "ENSG00000145216" "FIP1L1" "B4DIR3; G3XAD6; hsa:81608; Q0VGE0; Q499Y4; Q49AU3; Q6UN15; Q7Z608; Q8WVN3; Q96F80; Q9H077" "" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; Signaling by cytosolic PDGFRA and PDGFRB fusion proteins" "6" "0" "0.984" "0.994" "0.968" "1.013" "1.063" "1.016" "0.930" "0.919" "1.031" "1128.6" "1110.2" "1121.6" "1092.7" "1143.2" "1199.2" "1146.8" "1049.3" "1036.7" "1163.6" "" "" "" "" "" "" "" "" "" "" "1014.7" "898.3" "1014.6" "1066.6" "943.4" "1199.2" "858.7" "926.8" "927.7" "415.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1583650821826420104" "False" "High" "IsMasterProtein" "Q9H9A5" "CCR4-NOT transcription complex subunit 10 OS=Homo sapiens OX=9606 GN=CNOT10 PE=1 SV=1" "0.000" "False" "28.618" "13" "7" "9" "7" "744" "82.3" "7.78" "32.91" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "" "25904" "ENSG00000182973; ENSG00000291502" "CNOT10" "B7Z7L1; F8WAF2; hsa:25904; Q9BU30; Q9H5J7; Q9H8X1; Q9H9A5; Q9H9W0; Q9HAH3; Q9UFJ2" "Ciliary landscape" "M-decay: degradation of maternal mRNAs by maternally stored factors; Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain" "4" "0" "0.999" "1.000" "0.939" "1.028" "1.008" "1.009" "0.959" "0.980" "1.105" "617.5" "616.7" "617.8" "579.9" "634.9" "622.7" "623.2" "592.0" "605.1" "682.4" "" "" "" "" "" "" "" "" "" "" "555.2" "499.0" "558.8" "566.0" "523.9" "622.7" "466.6" "522.9" "541.4" "243.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7534759113121094513" "False" "High" "IsMasterProtein" "Q9Y3D9" "Small ribosomal subunit protein mS23 OS=Homo sapiens OX=9606 GN=MRPS23 PE=1 SV=2" "0.000" "False" "28.597" "42" "8" "12" "8" "190" "21.8" "8.90" "34.92" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf10484" "51649" "ENSG00000181610" "MRPS23" "B2R6V3; hsa:51649; Q96Q24; Q9BWH8; Q9P053; Q9Y3D9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.977" "0.928" "0.949" "0.918" "0.901" "0.976" "0.942" "0.921" "1.159" "1258.0" "1229.0" "1168.0" "1193.6" "1154.4" "1133.4" "1228.4" "1184.6" "1159.0" "1458.0" "" "" "" "" "" "" "" "" "" "" "1131.0" "994.4" "1056.5" "1165.1" "952.6" "1133.4" "919.8" "1046.3" "1037.0" "520.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7482733620363159602" "False" "High" "IsMasterProtein" "Q9BVS5" "tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TRMT61B PE=1 SV=2" "0.000" "False" "28.585" "17" "7" "10" "7" "477" "52.9" "6.62" "36.33" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf08704" "55006" "ENSG00000171103" "TRMT61B" "hsa:55006; Q9BVS5; Q9H0Q9; Q9NWS7" "" "tRNA modification in the mitochondrion" "1" "0" "0.999" "0.929" "0.909" "1.004" "1.051" "0.904" "1.016" "0.955" "0.773" "741.5" "741.0" "688.8" "674.2" "744.8" "779.3" "670.5" "753.2" "708.2" "573.3" "" "" "" "" "" "" "" "" "" "" "666.7" "599.6" "623.0" "658.1" "614.6" "779.3" "502.0" "665.3" "633.7" "204.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6029605810403186632" "False" "High" "IsMasterProtein" "Q14674" "Separin OS=Homo sapiens OX=9606 GN=ESPL1 PE=1 SV=3" "0.000" "False" "28.581" "5" "8" "9" "8" "2120" "233.0" "7.55" "29.48" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03568" "9700" "ENSG00000135476" "ESPL1" "hsa:9700; Q14674" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Urotensin-II-mediated signaling pathway" "Separation of Sister Chromatids" "4" "0" "0.940" "1.299" "0.920" "1.002" "1.270" "0.984" "0.932" "1.315" "1.588" "617.8" "580.5" "802.3" "568.4" "619.1" "784.6" "607.8" "576.0" "812.5" "981.3" "" "" "" "" "" "" "" "" "" "" "555.5" "469.7" "725.7" "554.8" "510.9" "784.6" "455.1" "508.8" "727.0" "350.3" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7123841880797263349" "False" "High" "IsMasterProtein" "P09382" "Galectin-1 OS=Homo sapiens OX=9606 GN=LGALS1 PE=1 SV=2" "0.000" "False" "28.456" "42" "5" "13" "5" "135" "14.7" "5.50" "53.91" "5" "cell adhesion;other biological processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00337" "3956" "ENSG00000100097" "LGALS1" "B2R5E8; hsa:3956; P09382; Q9UDK5" "Immune infiltration in pancreatic cancer" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "0.942" "0.946" "0.920" "0.996" "0.963" "0.945" "0.992" "0.962" "0.761" "1357.1" "1279.0" "1283.3" "1249.0" "1351.7" "1307.4" "1282.7" "1346.1" "1305.9" "1032.7" "" "" "" "" "" "" "" "" "" "" "1220.1" "1034.9" "1160.8" "1219.1" "1115.5" "1307.4" "960.4" "1188.9" "1168.5" "368.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1282007746480283530" "False" "High" "IsMasterProtein" "Q9BRJ7" "Tudor-interacting repair regulator protein OS=Homo sapiens OX=9606 GN=NUDT16L1 PE=1 SV=1" "0.000" "False" "28.401" "36" "7" "8" "6" "211" "23.3" "8.91" "32.95" "7" "other biological processes" "nucleus" "nucleic acid binding activity" "" "84309" "ENSG00000168101" "NUDT16L1" "Q8NAI2; Q9BRJ7" "" "" "0" "1" "1.048" "1.059" "1.001" "1.015" "1.027" "1.014" "1.048" "1.032" "0.871" "582.8" "611.0" "617.0" "583.4" "591.4" "598.5" "590.8" "610.9" "601.7" "507.9" "" "" "" "" "" "" "" "" "" "" "524.0" "494.4" "558.1" "569.4" "488.0" "598.5" "442.4" "539.5" "538.4" "181.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5646887584104105884" "False" "High" "IsMasterProtein" "Q9BW61" "DET1- and DDB1-associated protein 1 OS=Homo sapiens OX=9606 GN=DDA1 PE=1 SV=1" "0.000" "False" "28.391" "61" "6" "11" "6" "102" "11.8" "8.68" "44.26" "6" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf10172" "79016" "ENSG00000130311" "DDA1" "hsa:79016; Q9BW61" "" "Neddylation" "1" "0" "0.901" "1.092" "0.959" "0.996" "1.021" "0.942" "0.982" "1.051" "1.039" "535.7" "482.7" "585.2" "514.0" "533.4" "547.2" "504.9" "526.3" "563.2" "556.6" "" "" "" "" "" "" "" "" "" "" "481.7" "390.6" "529.3" "501.7" "440.1" "547.2" "378.0" "464.9" "503.9" "198.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818907558764607522" "False" "High" "IsMasterProtein" "Q8IWD4" "Coiled-coil domain-containing protein 117 OS=Homo sapiens OX=9606 GN=CCDC117 PE=1 SV=1" "0.000" "False" "28.388" "26" "8" "9" "8" "279" "30.5" "5.07" "37.54" "8" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf15810" "150275" "ENSG00000159873" "CCDC117" "A8K0F1; B7Z2V1; B7Z860; hsa:150275; Q6ICA7; Q8IWD4; Q8N278" "" "" "0" "0" "1.029" "1.089" "0.937" "1.024" "1.049" "1.070" "1.003" "1.107" "0.840" "631.0" "649.4" "687.1" "591.4" "645.9" "662.2" "674.9" "632.8" "698.7" "529.8" "" "" "" "" "" "" "" "" "" "" "567.3" "525.4" "621.5" "577.2" "533.0" "662.2" "505.3" "558.9" "625.2" "189.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4874402221689570626" "False" "High" "IsMasterProtein" "Q86W56" "Poly(ADP-ribose) glycohydrolase OS=Homo sapiens OX=9606 GN=PARG PE=1 SV=1" "0.000" "False" "28.363" "9" "9" "9" "9" "976" "111.0" "6.43" "30.78" "9" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf05028, Pf20811" "670; 8505" "ENSG00000227345" "PARG" "A5YBK3; B2RC24; B4DIU5; B4DYR4; hsa:8505; I6RUV3; Q6E4P6; Q6E4P7; Q7Z742; Q86W56; Q9Y4W7" "10q11.21q11.23 copy number variation syndrome" "POLB-Dependent Long Patch Base Excision Repair" "2" "0" "0.939" "0.940" "1.049" "0.948" "0.931" "1.054" "0.980" "0.937" "1.304" "475.9" "446.8" "447.6" "499.3" "451.1" "443.2" "501.5" "466.3" "445.8" "620.7" "" "" "" "" "" "" "" "" "" "" "427.9" "361.5" "404.9" "487.4" "372.2" "443.2" "375.5" "411.9" "398.9" "221.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9196998486354008360" "False" "High" "IsMasterProtein" "Q6F5E8" "Capping protein, Arp2/3 and myosin-I linker protein 2 OS=Homo sapiens OX=9606 GN=CARMIL2 PE=1 SV=2" "0.000" "False" "28.360" "7" "8" "9" "8" "1435" "154.6" "6.76" "32.92" "8" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13516, Pf16000, Pf17888" "146206" "ENSG00000159753" "CARMIL2" "B8X2Z3; hsa:146206; Q6F5E8" "" "" "0" "0" "1.015" "1.023" "1.008" "1.012" "1.014" "0.981" "0.969" "0.975" "1.156" "660.6" "670.6" "676.0" "665.6" "668.5" "669.8" "647.8" "640.0" "644.4" "764.0" "" "" "" "" "" "" "" "" "" "" "594.0" "542.7" "611.5" "649.7" "551.7" "669.8" "485.1" "565.3" "576.6" "272.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4005780129157962021" "False" "High" "IsMasterProtein" "Q9BUR4" "Telomerase Cajal body protein 1 OS=Homo sapiens OX=9606 GN=WRAP53 PE=1 SV=1" "0.000" "False" "28.331" "20" "6" "8" "6" "548" "59.3" "4.58" "35.33" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "55135" "ENSG00000141499" "WRAP53" "B3KPR9; D3DTQ4; hsa:55135; Q08ET9; Q9BUR4; Q9NW09" "" "Association of TriC/CCT with target proteins during biosynthesis; Telomere Extension By Telomerase" "2" "0" "1.003" "1.162" "0.910" "1.142" "1.140" "1.116" "1.055" "1.047" "0.813" "178.9" "179.5" "207.9" "162.7" "204.3" "204.0" "199.6" "188.8" "187.4" "145.5" "" "" "" "" "" "" "" "" "" "" "160.8" "145.2" "188.1" "158.9" "168.6" "204.0" "149.4" "166.7" "167.7" "51.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8311576936421810338" "False" "High" "IsMasterProtein" "Q6ZN28" "Metastasis-associated in colon cancer protein 1 OS=Homo sapiens OX=9606 GN=MACC1 PE=1 SV=2" "0.000" "False" "28.325" "8" "7" "9" "7" "852" "96.6" "6.90" "28.37" "7" "signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding" "" "346389" "ENSG00000183742" "MACC1" "A8MUS5; B2RNR9; hsa:346389; Q6ZN28; Q6ZQN8; Q7Z5A5" "" "" "0" "0" "1.001" "0.989" "0.936" "0.936" "0.939" "1.164" "0.922" "0.908" "0.948" "626.5" "627.0" "619.3" "586.1" "586.7" "588.1" "729.2" "577.4" "568.6" "593.9" "" "" "" "" "" "" "" "" "" "" "563.3" "507.4" "560.2" "572.1" "484.1" "588.1" "546.0" "510.0" "508.8" "212.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2253036871243965201" "False" "High" "IsMasterProtein" "Q15014" "Mortality factor 4-like protein 2 OS=Homo sapiens OX=9606 GN=MORF4L2 PE=1 SV=1" "0.000" "False" "28.321" "28" "7" "9" "5" "288" "32.3" "9.72" "28.88" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "" "Pf05712" "9643" "ENSG00000123562" "MORF4L2" "B3KP92; D3DXA5; hsa:9643; Q15014; Q567V0; Q8J026" "" "HATs acetylate histones" "1" "0" "0.993" "0.989" "0.908" "1.005" "0.952" "0.989" "0.993" "0.968" "0.867" "342.0" "339.7" "338.2" "310.4" "343.8" "325.5" "338.2" "339.5" "330.9" "296.6" "" "" "" "" "" "" "" "" "" "" "307.5" "274.8" "306.0" "303.0" "283.7" "325.5" "253.3" "299.9" "296.1" "105.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3851558283081104520" "False" "High" "IsMasterProtein" "Q14145" "Kelch-like ECH-associated protein 1 OS=Homo sapiens OX=9606 GN=KEAP1 PE=1 SV=2" "0.000" "False" "28.304" "12" "7" "8" "7" "624" "69.6" "6.44" "28.18" "7" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "9817" "ENSG00000079999" "KEAP1" "B3KPD5; hsa:9817; Q14145; Q6LEP0; Q8WTX1; Q9BPY9" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Hereditary leiomyomatosis and renal cell carcinoma pathway; NRF2-ARE regulation; Head and neck squamous cell carcinoma; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway" "Potential therapeutics for SARS; Antigen processing: Ubiquitination & Proteasome degradation; Ub-specific processing proteases; Neddylation; KEAP1-NFE2L2 pathway; Nuclear events mediated by NFE2L2" "16" "0" "1.026" "1.034" "0.975" "1.068" "1.058" "1.091" "0.972" "1.025" "1.342" "724.6" "743.2" "749.2" "706.4" "774.0" "766.9" "790.4" "704.3" "742.6" "972.3" "" "" "" "" "" "" "" "" "" "" "651.4" "601.4" "677.7" "689.6" "638.7" "766.9" "591.9" "622.1" "664.5" "347.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4102844417532121967" "False" "High" "IsMasterProtein" "Q15560" "Transcription elongation factor A protein 2 OS=Homo sapiens OX=9606 GN=TCEA2 PE=1 SV=1" "0.000" "False" "28.280" "18" "6" "13" "3" "299" "33.6" "9.13" "49.34" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6919" "ENSG00000171703" "TCEA2" "B3KNM1; Q15560; Q8TD37; Q8TD38" "" "" "0" "0" "1.102" "1.208" "1.088" "1.289" "1.206" "1.221" "1.263" "1.141" "1.486" "115.8" "127.7" "139.9" "126.0" "149.3" "139.7" "141.4" "146.3" "132.2" "172.1" "" "" "" "" "" "" "" "" "" "" "104.1" "103.3" "126.6" "123.0" "123.2" "139.7" "105.9" "129.2" "118.3" "61.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4009101809611603487" "False" "High" "IsMasterProtein" "Q9NUW8" "Tyrosyl-DNA phosphodiesterase 1 OS=Homo sapiens OX=9606 GN=TDP1 PE=1 SV=2" "0.000" "False" "28.280" "14" "8" "9" "8" "608" "68.4" "7.65" "31.38" "8" "DNA metabolism;other metabolic processes;stress response" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06087" "55775" "ENSG00000042088" "TDP1" "hsa:55775; Q2HXX4; Q86TV8; Q96BK7; Q9NUW8; Q9NZM7; Q9NZM8" "" "Nonhomologous End-Joining (NHEJ)" "1" "0" "1.078" "1.052" "1.024" "1.177" "1.072" "1.141" "1.071" "1.171" "1.528" "477.6" "514.7" "502.4" "488.9" "561.9" "511.9" "544.7" "511.4" "559.4" "729.6" "" "" "" "" "" "" "" "" "" "" "429.4" "416.5" "454.4" "477.2" "463.7" "511.9" "407.9" "451.7" "500.6" "260.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3386437626543326564" "False" "High" "IsMasterProtein" "Q9BWE0" "DNA-binding protein REPIN1 OS=Homo sapiens OX=9606 GN=REPIN1 PE=1 SV=1" "0.000" "False" "28.268" "18" "8" "10" "8" "567" "63.5" "9.98" "39.44" "8" "DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "29803" "ENSG00000214022" "REPIN1" "C9J3L7; D3DWZ1; hsa:29803; Q7LE03; Q9BUZ6; Q9BWE0; Q9NZH2; Q9UMP5" "" "" "0" "0" "0.998" "1.089" "0.961" "1.009" "1.046" "1.005" "0.961" "1.079" "0.876" "564.0" "562.9" "614.0" "541.7" "569.0" "590.0" "566.9" "542.2" "608.5" "494.0" "" "" "" "" "" "" "" "" "" "" "507.0" "455.5" "555.3" "528.8" "469.5" "590.0" "424.5" "478.9" "544.5" "176.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "779708130048871486" "False" "High" "IsMasterProtein" "O43464" "Serine protease HTRA2, mitochondrial OS=Homo sapiens OX=9606 GN=HTRA2 PE=1 SV=2" "0.000" "False" "28.240" "19" "8" "10" "8" "458" "48.8" "10.07" "39.00" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13365, Pf17820" "27429" "ENSG00000115317" "HTRA2" "hsa:27429; O43464; Q9HBZ4; Q9P0Y3; Q9P0Y4" "Apoptosis modulation and signaling; Parkinson's disease pathway; Nanomaterial induced apoptosis; Ciliary landscape; Complement system in neuronal development and plasticity" "Mitochondrial protein degradation" "6" "0" "1.051" "1.009" "1.057" "1.107" "0.994" "1.097" "1.099" "1.023" "0.821" "595.0" "625.4" "600.4" "629.1" "658.7" "591.5" "652.6" "653.8" "608.8" "488.6" "" "" "" "" "" "" "" "" "" "" "535.0" "506.0" "543.1" "614.1" "543.6" "591.5" "488.7" "577.5" "544.7" "174.4" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7640891103846222335" "False" "High" "IsMasterProtein" "O94819" "Kelch repeat and BTB domain-containing protein 11 OS=Homo sapiens OX=9606 GN=KBTBD11 PE=1 SV=1" "0.000" "False" "28.235" "19" "9" "12" "9" "623" "65.7" "6.07" "43.00" "9" "" "" "" "Pf00651, Pf01344" "9920" "ENSG00000176595; ENSG00000273645" "KBTBD11" "hsa:9920; O94819; Q3L1I0" "" "" "0" "0" "0.997" "0.993" "0.961" "1.046" "0.972" "1.027" "0.958" "0.917" "1.001" "465.7" "464.0" "462.2" "447.6" "486.9" "452.5" "478.3" "446.2" "427.2" "465.9" "" "" "" "" "" "" "" "" "" "" "418.7" "375.5" "418.1" "437.0" "401.8" "452.5" "358.1" "394.1" "382.2" "166.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4422070484711978078" "False" "High" "IsMasterProtein" "O95684" "Centrosomal protein 43 OS=Homo sapiens OX=9606 GN=CEP43 PE=1 SV=1" "0.000" "False" "28.221" "19" "6" "7" "6" "399" "43.0" "4.81" "32.84" "6" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf09398" "11116" "ENSG00000213066" "CEP43" "A8K1D1; B2R705; hsa:11116; O95684; Q49AI0; Q5R3F6; Q96EW1" "Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "0" "0.950" "0.939" "0.944" "1.007" "0.900" "0.975" "0.988" "0.989" "0.970" "736.8" "699.9" "692.1" "695.8" "741.9" "663.1" "718.7" "727.6" "728.7" "715.0" "" "" "" "" "" "" "" "" "" "" "662.5" "566.4" "626.0" "679.2" "612.2" "663.1" "538.2" "642.7" "652.0" "255.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2647028449518715682" "False" "High" "IsMasterProtein" "P16383" "Intron Large complex component GCFC2 OS=Homo sapiens OX=9606 GN=GCFC2 PE=1 SV=2" "0.000" "False" "28.171" "11" "6" "7" "6" "781" "89.3" "5.99" "25.79" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf07842" "6936" "ENSG00000005436" "GCFC2" "A4UHQ8; A4UHQ9; hsa:6936; O95032; P16383; Q53TY0; Q6P2F2" "" "mRNA Splicing - Major Pathway" "1" "0" "0.912" "0.834" "0.921" "0.946" "0.860" "0.865" "0.967" "0.921" "1.390" "214.1" "195.3" "178.5" "197.1" "202.4" "184.1" "185.2" "207.0" "197.1" "297.6" "" "" "" "" "" "" "" "" "" "" "192.5" "158.0" "161.4" "192.4" "167.0" "184.1" "138.7" "182.8" "176.3" "106.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7707069974883679945" "False" "High" "IsMasterProtein" "P11836" "B-lymphocyte antigen CD20 OS=Homo sapiens OX=9606 GN=MS4A1 PE=1 SV=1" "0.000" "False" "28.158" "20" "5" "10" "5" "297" "33.1" "5.05" "38.21" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf04103" "931" "ENSG00000156738" "MS4A1" "A6NMS4; B4DT24; hsa:931; P08984; P11836; Q13963" "Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "" "2" "0" "0.884" "0.810" "0.988" "0.863" "0.807" "0.944" "0.941" "0.932" "0.650" "559.7" "494.7" "453.1" "553.3" "483.0" "451.5" "528.5" "526.6" "521.5" "363.6" "" "" "" "" "" "" "" "" "" "" "503.3" "400.3" "409.9" "540.1" "398.5" "451.5" "395.7" "465.1" "466.6" "129.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739657141075103728" "False" "High" "IsMasterProtein" "Q9NRN9" "rRNA N6-adenosine-methyltransferase METTL5 OS=Homo sapiens OX=9606 GN=METTL5 PE=1 SV=1" "0.000" "False" "28.142" "37" "7" "11" "7" "209" "23.7" "6.68" "39.82" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29081" "ENSG00000138382" "METTL5" "D3DPC9; hsa:29081; Q9NRN9; Q9NVX1" "" "" "0" "0" "1.067" "1.010" "0.948" "1.037" "0.934" "1.029" "0.973" "1.018" "0.842" "882.0" "940.9" "891.2" "836.1" "914.4" "824.1" "907.6" "858.5" "898.3" "743.0" "" "" "" "" "" "" "" "" "" "" "793.0" "761.4" "806.1" "816.2" "754.6" "824.1" "679.6" "758.3" "803.8" "265.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932263568853688601" "False" "High" "IsMasterProtein" "Q9UKA9" "Polypyrimidine tract-binding protein 2 OS=Homo sapiens OX=9606 GN=PTBP2 PE=1 SV=1" "0.000" "False" "28.142" "16" "8" "24" "7" "531" "57.5" "8.66" "71.98" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076, Pf11835, Pf13893" "58155" "ENSG00000117569" "PTBP2" "hsa:58155; Q8N0Z1; Q8N160; Q8NFB0; Q8NFB1; Q969N9; Q96Q76; Q9UKA9" "Genes targeted by miRNAs in adipocytes; mRNA processing" "" "2" "0" "1.027" "1.007" "0.942" "0.962" "0.903" "1.002" "0.985" "0.866" "1.185" "676.7" "695.2" "681.4" "637.6" "650.8" "611.4" "678.3" "666.9" "585.9" "802.2" "" "" "" "" "" "" "" "" "" "" "608.5" "562.5" "616.4" "622.4" "537.1" "611.4" "507.9" "589.1" "524.3" "286.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174641781052764353" "False" "High" "IsMasterProtein" "Q9P2T1" "GMP reductase 2 OS=Homo sapiens OX=9606 GN=GMPR2 PE=1 SV=1" "0.000" "False" "28.136" "34" "12" "19" "12" "348" "37.9" "7.23" "48.18" "12" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00478" "51292" "ENSG00000100938; ENSG00000284752" "GMPR2" "D3DS66; hsa:51292; Q567T0; Q6IAJ8; Q86T14; Q9P2T1" "" "Purine salvage" "1" "0" "1.019" "1.040" "1.066" "1.057" "0.997" "1.046" "0.965" "1.050" "0.806" "1574.3" "1604.9" "1636.7" "1678.1" "1663.7" "1569.7" "1646.6" "1518.5" "1653.1" "1268.4" "" "" "" "" "" "" "" "" "" "" "1415.4" "1298.6" "1480.5" "1638.0" "1372.9" "1569.7" "1232.9" "1341.3" "1479.1" "452.8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8194850060938304098" "False" "High" "IsMasterProtein" "Q8N5I9" "NOP protein chaperone 1 OS=Homo sapiens OX=9606 GN=NOPCHAP1 PE=1 SV=2" "0.000" "False" "28.133" "43" "7" "10" "7" "185" "20.1" "5.22" "34.76" "7" "cell organization and biogenesis" "nucleus" "other molecular function" "Pf15370" "121053" "ENSG00000151131" "NOPCHAP1" "Q8N5I9" "" "" "0" "0" "0.935" "0.964" "1.016" "0.990" "1.001" "0.940" "1.035" "1.047" "0.943" "461.3" "431.5" "444.6" "468.6" "456.9" "461.6" "433.4" "477.2" "482.8" "434.9" "" "" "" "" "" "" "" "" "" "" "414.7" "349.1" "402.2" "457.4" "377.0" "461.6" "324.5" "421.5" "432.0" "155.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694143023947037177" "False" "High" "IsMasterProtein" "Q96I15" "Selenocysteine lyase OS=Homo sapiens OX=9606 GN=SCLY PE=1 SV=4" "0.000" "False" "28.131" "18" "6" "8" "6" "445" "48.1" "7.12" "32.21" "6" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00266" "51540" "ENSG00000132330" "SCLY" "B9A068; hsa:51540; J3KN06; Q53SN1; Q53SN8; Q7L670; Q96I15; Q9NVT7; Q9NZR7" "Selenium metabolism and selenoproteins; 2q37 copy number variation syndrome" "Metabolism of ingested SeMet, Sec, MeSec into H2Se" "3" "0" "1.055" "1.037" "1.012" "1.135" "1.013" "0.967" "1.061" "1.073" "1.247" "262.7" "277.1" "272.4" "265.7" "298.1" "266.0" "254.0" "278.7" "281.7" "327.5" "" "" "" "" "" "" "" "" "" "" "236.2" "224.3" "246.4" "259.4" "246.0" "266.0" "190.2" "246.2" "252.1" "116.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5023759696218809409" "False" "High" "IsMasterProtein" "Q7Z434" "Mitochondrial antiviral-signaling protein OS=Homo sapiens OX=9606 GN=MAVS PE=1 SV=2" "0.000" "False" "28.122" "16" "6" "8" "6" "540" "56.5" "5.52" "32.63" "6" "stress response;signal transduction;other biological processes" "other membranes;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf16739" "57506" "ENSG00000088888" "MAVS" "A8K6X0; B2BD33; B2BD34; F5H6C8; hsa:57506; M1P2Z0; Q2HWT5; Q3I0Y2; Q5T7I6; Q7Z434; Q86VY7; Q9H1H3; Q9H4Y1; Q9H8D3; Q9ULE9" "Novel intracellular components of RIG-I-like receptor pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Negative regulators of DDX58/IFIH1 signaling; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; PKR-mediated signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Ovarian tumor domain proteases" "24" "0" "1.032" "0.986" "1.025" "0.993" "0.974" "1.079" "1.029" "0.957" "0.809" "732.2" "755.4" "721.8" "750.2" "727.0" "713.4" "790.3" "753.6" "700.6" "592.1" "" "" "" "" "" "" "" "" "" "" "658.3" "611.2" "652.9" "732.3" "599.9" "713.4" "591.7" "665.7" "626.9" "211.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "698567651492244617" "False" "High" "IsMasterProtein" "Q96RL7" "Intermembrane lipid transfer protein VPS13A OS=Homo sapiens OX=9606 GN=VPS13A PE=1 SV=2" "0.000" "False" "28.107" "4" "10" "10" "10" "3174" "360.0" "6.33" "28.37" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06650, Pf09333, Pf12624, Pf16908, Pf16909, Pf16910, Pf21679" "23230" "ENSG00000197969" "VPS13A" "hsa:23230; Q5JSX9; Q5JSY0; Q5VYR5; Q702P4; Q709D0; Q86YF8; Q96RL7; Q96S61; Q9H995; Q9Y2J1" "" "" "0" "0" "1.099" "1.032" "0.948" "0.877" "0.900" "1.008" "0.999" "0.984" "0.918" "445.3" "489.5" "459.5" "421.9" "390.6" "400.7" "448.9" "445.0" "438.0" "408.9" "" "" "" "" "" "" "" "" "" "" "400.4" "396.1" "415.6" "411.9" "322.3" "400.7" "336.1" "393.1" "391.9" "146.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758380383998066899" "False" "High" "IsMasterProtein" "Q86V81" "THO complex subunit 4 OS=Homo sapiens OX=9606 GN=ALYREF PE=1 SV=3" "0.000" "False" "28.106" "27" "5" "9" "5" "257" "26.9" "11.15" "34.68" "5" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf13865" "10189" "" "ALYREF" "hsa:10189; O43672; Q86V81" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "7" "0" "0.952" "0.984" "0.921" "1.036" "1.199" "0.912" "0.910" "0.802" "0.791" "474.9" "452.4" "467.2" "437.6" "492.0" "569.4" "433.2" "432.2" "380.8" "375.8" "" "" "" "" "" "" "" "" "" "" "427.0" "366.1" "422.6" "427.2" "406.0" "569.4" "324.4" "381.7" "340.7" "134.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6009675423733223461" "False" "High" "IsMasterProtein" "Q96B54" "Zinc finger protein 428 OS=Homo sapiens OX=9606 GN=ZNF428 PE=1 SV=2" "0.000" "False" "28.100" "30" "4" "8" "4" "188" "20.5" "4.17" "35.19" "4" "" "" "other molecular function" "" "126299" "ENSG00000131116" "ZNF428" "hsa:126299; O95054; Q6X3Y3; Q96B54" "" "" "0" "0" "1.014" "1.088" "1.056" "1.063" "1.116" "1.057" "1.011" "1.004" "0.766" "440.3" "446.5" "478.9" "465.1" "468.1" "491.4" "465.2" "445.0" "442.2" "337.4" "" "" "" "" "" "" "" "" "" "" "395.8" "361.3" "433.2" "454.0" "386.3" "491.4" "348.3" "393.1" "395.6" "120.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335320329939268762" "False" "High" "IsMasterProtein" "Q9UBR2" "Cathepsin Z OS=Homo sapiens OX=9606 GN=CTSZ PE=1 SV=1" "0.000" "False" "28.099" "21" "6" "9" "6" "303" "33.8" "7.11" "35.32" "6" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112" "1522" "ENSG00000101160" "CTSZ" "B2RC40; hsa:1522; O75331; Q9UBR2; Q9UQV5; Q9UQV6" "" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Lysosome Vesicle Biogenesis; COPII-mediated vesicle transport; Cargo concentration in the ER" "5" "0" "1.019" "1.002" "0.965" "1.000" "0.970" "0.981" "0.977" "0.993" "0.790" "1300.2" "1324.6" "1303.3" "1254.5" "1300.6" "1260.9" "1275.2" "1270.7" "1291.3" "1026.6" "" "" "" "" "" "" "" "" "" "" "1169.0" "1071.8" "1178.9" "1224.5" "1073.3" "1260.9" "954.8" "1122.4" "1155.5" "366.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2264903312611257722" "False" "High" "IsMasterProtein" "Q05469" "Hormone-sensitive lipase OS=Homo sapiens OX=9606 GN=LIPE PE=1 SV=4" "0.000" "False" "28.060" "11" "9" "9" "9" "1076" "116.5" "6.70" "36.44" "9" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf06350, Pf07859" "3991" "ENSG00000079435" "LIPE" "hsa:3991; Q05469; Q3LRT2; Q6NSL7" "AMP-activated protein kinase signaling; Fatty acid beta-oxidation; Adipogenesis; Triacylglyceride synthesis; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Lipid metabolism pathway; Thermogenesis; Insulin signaling; Orexin receptor pathway; Familial partial lipodystrophy" "Triglyceride catabolism" "11" "0" "1.038" "1.007" "0.938" "0.995" "1.010" "1.024" "1.016" "0.969" "1.194" "502.7" "521.6" "506.2" "471.4" "500.2" "508.0" "514.6" "511.0" "487.2" "600.4" "" "" "" "" "" "" "" "" "" "" "452.0" "422.1" "457.8" "460.2" "412.8" "508.0" "385.3" "451.3" "436.0" "214.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5766769550040713609" "False" "High" "IsMasterProtein" "Q9UHI6" "Probable ATP-dependent RNA helicase DDX20 OS=Homo sapiens OX=9606 GN=DDX20 PE=1 SV=2" "0.000" "False" "28.048" "11" "8" "10" "8" "824" "92.2" "6.95" "24.31" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "11218" "ENSG00000064703" "DDX20" "B4DWV7; hsa:11218; Q96F72; Q9NVM3; Q9UF59; Q9UHI6; Q9UIY0; Q9Y659" "mRNA processing; Male infertility" "SARS-CoV-2 modulates host translation machinery; snRNP Assembly" "4" "0" "1.074" "1.013" "1.024" "1.047" "0.984" "1.030" "1.040" "1.059" "1.248" "383.4" "411.7" "388.4" "392.8" "401.5" "377.4" "395.1" "399.0" "406.2" "478.5" "" "" "" "" "" "" "" "" "" "" "344.8" "333.2" "351.4" "383.4" "331.4" "377.4" "295.9" "352.4" "363.5" "170.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7848338417616042821" "False" "High" "IsMasterProtein" "P35270" "Sepiapterin reductase OS=Homo sapiens OX=9606 GN=SPR PE=1 SV=1" "0.000" "False" "28.020" "40" "9" "11" "9" "261" "28.0" "8.05" "40.50" "9" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00106" "6697" "ENSG00000116096" "SPR" "A8K741; D6W5H2; hsa:6697; P35270; Q53GI9; Q9UBB1" "" "eNOS activation; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "1.019" "0.991" "0.983" "1.026" "1.007" "1.060" "0.992" "0.968" "1.014" "401.8" "409.3" "398.4" "395.1" "412.1" "404.6" "426.0" "398.7" "389.0" "407.3" "" "" "" "" "" "" "" "" "" "" "361.3" "331.2" "360.4" "385.7" "340.1" "404.6" "319.0" "352.2" "348.1" "145.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5010086175827698668" "False" "High" "IsMasterProtein" "P42575" "Caspase-2 OS=Homo sapiens OX=9606 GN=CASP2 PE=1 SV=2" "0.000" "False" "28.010" "18" "8" "11" "8" "452" "50.7" "6.81" "24.72" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00619, Pf00656" "835" "ENSG00000106144" "CASP2" "A8K5F9; D3DXD6; E9PDN0; hsa:835; P42575; P42576; Q59F21; Q7KZL6; Q86UJ3; Q9BUP7; Q9BZK9; Q9BZL0" "Apoptosis modulation and signaling; Parkinson's disease pathway; Apoptosis; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; NOD1/2 Signaling Pathway; NADE modulates death signalling" "8" "0" "1.052" "1.054" "1.077" "1.086" "1.062" "1.018" "1.037" "1.088" "1.271" "328.9" "346.1" "346.7" "354.1" "357.3" "349.1" "334.8" "340.9" "357.8" "418.0" "" "" "" "" "" "" "" "" "" "" "295.7" "280.0" "313.6" "345.6" "294.8" "349.1" "250.7" "301.1" "320.1" "149.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7226470696601852520" "False" "High" "IsMasterProtein" "Q9H0A8" "COMM domain-containing protein 4 OS=Homo sapiens OX=9606 GN=COMMD4 PE=1 SV=1" "0.000" "False" "27.977" "32" "6" "12" "6" "199" "21.8" "7.31" "44.20" "6" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf07258, Pf21672" "54939" "ENSG00000140365" "COMMD4" "B2RBN4; H3BUL2; hsa:54939; Q7L637; Q9H0A8; Q9NX43" "" "Neddylation" "1" "0" "0.978" "0.978" "0.912" "0.989" "0.937" "0.896" "0.961" "0.928" "1.163" "503.3" "492.3" "492.3" "459.2" "497.5" "471.4" "450.7" "483.7" "466.9" "585.1" "" "" "" "" "" "" "" "" "" "" "452.5" "398.4" "445.3" "448.3" "410.6" "471.4" "337.5" "427.3" "417.8" "208.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7964397888877464485" "False" "High" "IsMasterProtein" "P50897" "Palmitoyl-protein thioesterase 1 OS=Homo sapiens OX=9606 GN=PPT1 PE=1 SV=1" "0.000" "False" "27.973" "24" "6" "8" "6" "306" "34.2" "6.52" "33.90" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02089" "5538" "ENSG00000131238" "PPT1" "B4DY24; hsa:5538; P50897; Q6FGQ4" "" "Fatty acyl-CoA biosynthesis" "1" "0" "0.887" "0.987" "0.859" "0.847" "0.799" "0.871" "0.909" "0.827" "0.661" "699.6" "620.4" "690.6" "600.7" "592.6" "558.7" "609.6" "636.2" "578.9" "462.2" "" "" "" "" "" "" "" "" "" "" "629.0" "502.0" "624.6" "586.3" "489.0" "558.7" "456.4" "562.0" "518.0" "165.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2014587900474496052" "False" "High" "IsMasterProtein" "Q9P015" "Large ribosomal subunit protein uL15m OS=Homo sapiens OX=9606 GN=MRPL15 PE=1 SV=1" "0.000" "False" "27.969" "22" "7" "9" "7" "296" "33.4" "10.01" "36.14" "7" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00828" "29088" "ENSG00000137547" "MRPL15" "hsa:29088; Q96Q54; Q9H0Y1; Q9P015" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.983" "0.965" "0.978" "1.006" "0.927" "0.994" "1.032" "1.007" "1.097" "1116.4" "1097.7" "1076.9" "1091.5" "1123.3" "1034.4" "1110.0" "1152.0" "1124.6" "1224.2" "" "" "" "" "" "" "" "" "" "" "1003.8" "888.2" "974.1" "1065.5" "927.0" "1034.4" "831.1" "1017.6" "1006.3" "437.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-296072814185556824" "False" "High" "IsMasterProtein" "Q9BUI4" "DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens OX=9606 GN=POLR3C PE=1 SV=1" "0.000" "False" "27.961" "17" "8" "10" "8" "534" "60.6" "7.31" "28.92" "8" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05645, Pf08221, Pf20912" "10623" "ENSG00000186141" "POLR3C" "hsa:10623; O15317; Q9BUI4; Q9Y3R6" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.055" "0.959" "1.010" "1.080" "0.908" "1.025" "1.014" "0.954" "1.158" "664.2" "700.7" "636.7" "670.6" "717.6" "603.2" "680.7" "673.4" "633.8" "769.5" "" "" "" "" "" "" "" "" "" "" "597.2" "567.0" "575.9" "654.6" "592.2" "603.2" "509.7" "594.8" "567.1" "274.7" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7785490494886001566" "False" "High" "IsMasterProtein" "A6NC98" "Coiled-coil domain-containing protein 88B OS=Homo sapiens OX=9606 GN=CCDC88B PE=1 SV=1" "0.000" "False" "27.950" "6" "8" "9" "8" "1476" "164.7" "5.11" "30.22" "8" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf19047" "283234" "ENSG00000168071" "CCDC88B" "A5D8Y5; A6NC98; B5MDM2; hsa:283234; Q05BL2; Q6RUV3; Q8N1Q6; Q8NF44; Q9H0H1" "" "" "0" "0" "0.973" "1.002" "0.943" "1.006" "0.962" "1.042" "0.951" "0.984" "2.839" "659.5" "641.3" "661.0" "622.1" "663.3" "634.6" "687.0" "627.3" "648.6" "1872.3" "" "" "" "" "" "" "" "" "" "" "592.9" "519.0" "597.9" "607.3" "547.4" "634.6" "514.4" "554.0" "580.4" "668.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869941848494998165" "False" "High" "IsMasterProtein" "O75170" "Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens OX=9606 GN=PPP6R2 PE=1 SV=2" "0.000" "False" "27.949" "10" "8" "8" "7" "966" "104.9" "4.87" "28.31" "8" "" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04499" "9701" "ENSG00000100239" "PPP6R2" "A6PVG3; B7Z7T3; hsa:9701; O75170; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9" "" "" "0" "0" "1.093" "1.013" "0.914" "1.182" "1.102" "1.056" "0.986" "1.143" "1.070" "405.4" "443.1" "410.5" "370.4" "479.4" "446.9" "427.9" "399.8" "463.5" "433.7" "" "" "" "" "" "" "" "" "" "" "364.5" "358.5" "371.3" "361.6" "395.6" "446.9" "320.4" "353.2" "414.7" "154.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "376281410555249272" "False" "High" "IsMasterProtein" "O75592" "E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens OX=9606 GN=MYCBP2 PE=1 SV=4" "0.000" "False" "27.895" "2" "10" "10" "10" "4678" "513.3" "7.02" "31.20" "10" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00415, Pf03256, Pf08005, Pf13540" "23077" "ENSG00000005810" "MYCBP2" "A6NJC6; O75592; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4" "3q29 copy number variation syndrome" "" "1" "0" "0.975" "1.065" "0.868" "0.924" "0.865" "0.931" "0.977" "0.925" "1.293" "332.1" "323.6" "353.8" "288.2" "306.8" "287.1" "309.0" "324.3" "307.2" "429.4" "" "" "" "" "" "" "" "" "" "" "298.5" "261.8" "320.0" "281.3" "253.2" "287.1" "231.4" "286.4" "274.9" "153.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4995074517937679177" "False" "High" "IsMasterProtein" "O95628" "CCR4-NOT transcription complex subunit 4 OS=Homo sapiens OX=9606 GN=CNOT4 PE=1 SV=3" "0.000" "False" "27.855" "17" "8" "11" "8" "575" "63.5" "7.03" "40.88" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00076, Pf14570" "4850" "ENSG00000080802" "CNOT4" "B7Z6I4; E7ET38; F8VQP3; O95339; O95627; O95628; Q8IYM7; Q8NCL0; Q9NPQ1; Q9NZN6" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.170" "1.038" "1.076" "1.036" "1.232" "1.090" "1.062" "1.063" "0.896" "160.5" "187.7" "166.6" "172.6" "166.2" "197.7" "174.9" "170.4" "170.5" "143.8" "" "" "" "" "" "" "" "" "" "" "144.3" "151.9" "150.7" "168.5" "137.2" "197.7" "131.0" "150.5" "152.6" "51.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3673508278002205446" "False" "High" "IsMasterProtein" "P36542" "ATP synthase subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1C PE=1 SV=1" "0.000" "False" "27.852" "27" "8" "11" "7" "298" "33.0" "9.22" "34.16" "8" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf00231" "509" "ENSG00000165629" "ATP5F1C" "A8KA31; hsa:509; P36542; Q5VYP3; Q6I9V2; Q96AS8" "Electron transport chain: OXPHOS system in mitochondria" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.959" "1.068" "0.910" "0.975" "0.993" "0.936" "1.010" "1.015" "0.838" "1027.9" "986.2" "1098.3" "935.2" "1002.0" "1020.8" "961.9" "1037.8" "1043.4" "861.2" "" "" "" "" "" "" "" "" "" "" "924.2" "798.0" "993.4" "912.9" "826.9" "1020.8" "720.3" "916.6" "933.6" "307.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3949096695489977400" "False" "High" "IsMasterProtein" "P05386" "Large ribosomal subunit protein P1 OS=Homo sapiens OX=9606 GN=RPLP1 PE=1 SV=1" "0.000" "False" "27.846" "29" "3" "17" "1" "114" "11.5" "4.32" "60.83" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;other molecular function" "Pf00428" "6176" "ENSG00000137818" "RPLP1" "A6NIB2; hsa:6176; P05386" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.959" "0.932" "1.010" "1.131" "1.048" "1.038" "1.211" "1.012" "0.897" "177.9" "170.7" "165.8" "179.7" "201.3" "186.6" "184.6" "215.5" "180.0" "159.6" "" "" "" "" "" "" "" "" "" "" "160.0" "138.1" "149.9" "175.4" "166.1" "186.6" "138.3" "190.4" "161.1" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3934808494784224808" "False" "High" "IsMasterProtein" "Q96FJ2" "Dynein light chain 2, cytoplasmic OS=Homo sapiens OX=9606 GN=DYNLL2 PE=1 SV=1" "0.000" "False" "27.840" "58" "5" "12" "2" "89" "10.3" "7.37" "47.11" "5" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf01221" "140735" "ENSG00000264364" "DYNLL2" "B2R5B4; hsa:140735; Q96FJ2" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Vasopressin-regulated water reabsorption" "Separation of Sister Chromatids; MHC class II antigen presentation; Aggrephagy; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; RHO GTPases Activate Formins; HCMV Early Events; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Intraflagellar transport; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic; Macroautophagy; Activation of BMF and translocation to mitochondria" "19" "0" "0.859" "0.957" "0.954" "0.951" "0.964" "0.947" "0.951" "0.998" "1.014" "426.0" "366.1" "407.9" "406.3" "405.1" "410.7" "403.5" "405.2" "425.1" "432.1" "" "" "" "" "" "" "" "" "" "" "383.1" "296.2" "368.9" "396.7" "334.3" "410.7" "302.1" "357.9" "380.3" "154.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5034217840069919209" "False" "High" "IsMasterProtein" "O95721" "Synaptosomal-associated protein 29 OS=Homo sapiens OX=9606 GN=SNAP29 PE=1 SV=1" "0.000" "False" "27.830" "29" "6" "9" "6" "258" "29.0" "5.81" "35.90" "6" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "9342" "ENSG00000099940" "SNAP29" "hsa:9342; O95721" "Ciliary landscape; 22q11.2 copy number variation syndrome" "Intra-Golgi traffic; Neutrophil degranulation" "4" "0" "0.974" "1.039" "0.977" "1.068" "1.094" "1.014" "1.048" "1.018" "0.930" "510.4" "497.1" "530.5" "498.6" "544.9" "558.6" "517.6" "535.1" "519.3" "474.8" "" "" "" "" "" "" "" "" "" "" "458.9" "402.2" "479.8" "486.7" "449.6" "558.6" "387.6" "472.6" "464.7" "169.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476306151852591039" "False" "High" "IsMasterProtein" "Q15102" "Platelet-activating factor acetylhydrolase IB subunit alpha1 OS=Homo sapiens OX=9606 GN=PAFAH1B3 PE=1 SV=1" "0.000" "False" "27.830" "22" "5" "13" "5" "231" "25.7" "6.84" "46.68" "5" "other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13472" "5050" "ENSG00000079462" "PAFAH1B3" "hsa:5050; Q15102; Q53X88" "PAFAH1B1 copy number variation" "COPI-independent Golgi-to-ER retrograde traffic" "2" "0" "1.075" "1.011" "0.955" "1.049" "1.014" "1.071" "0.987" "0.971" "1.323" "585.6" "629.5" "592.1" "559.3" "614.3" "593.5" "626.9" "578.1" "568.4" "774.9" "" "" "" "" "" "" "" "" "" "" "526.5" "509.4" "535.6" "545.9" "506.9" "593.5" "469.4" "510.6" "508.6" "276.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630318732500359632" "False" "High" "IsMasterProtein" "P62280" "Small ribosomal subunit protein uS17 OS=Homo sapiens OX=9606 GN=RPS11 PE=1 SV=3" "0.000" "False" "27.807" "37" "8" "10" "8" "158" "18.4" "10.30" "34.54" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00366, Pf16205" "6205" "ENSG00000142534" "RPS11" "B2R4F5; hsa:6205; P04643; P62280; Q498Y6; Q6IRY0" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Cytoplasmic ribosomal proteins" "SARS-CoV-2 modulates host translation machinery; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "21" "0" "0.853" "0.841" "0.840" "0.799" "0.820" "0.786" "0.822" "0.933" "1.061" "1646.5" "1403.9" "1384.6" "1383.6" "1315.9" "1349.6" "1294.0" "1353.3" "1536.9" "1746.8" "" "" "" "" "" "" "" "" "" "" "1480.4" "1136.0" "1252.5" "1350.6" "1085.9" "1349.6" "968.9" "1195.3" "1375.2" "623.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214504578644122811" "False" "High" "IsMasterProtein" "P62942" "Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Homo sapiens OX=9606 GN=FKBP1A PE=1 SV=2" "0.000" "False" "27.795" "29" "3" "21" "3" "108" "11.9" "8.16" "73.35" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00254" "2280" "ENSG00000088832" "FKBP1A" "D3DVW6; hsa:2280; P20071; P62942; Q4VC47; Q6FGD9; Q6LEU3; Q9H103; Q9H566" "Target of rapamycin signaling; Spinal cord injury; Head and neck squamous cell carcinoma; TGF-beta receptor signaling in skeletal dysplasias; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells; TGF-beta receptor signaling" "Potential therapeutics for SARS; mTORC1-mediated signalling; SARS-CoV-1 activates/modulates innate immune responses; TGF-beta receptor signaling activates SMADs; Calcineurin activates NFAT; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR1 LBD Mutants in Cancer" "14" "0" "0.944" "0.902" "0.961" "1.011" "0.967" "0.990" "1.033" "0.963" "0.835" "1589.0" "1500.6" "1433.0" "1527.6" "1606.3" "1535.8" "1572.6" "1641.6" "1530.1" "1326.8" "" "" "" "" "" "" "" "" "" "" "1428.7" "1214.2" "1296.2" "1491.1" "1325.6" "1535.8" "1177.5" "1449.9" "1369.1" "473.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3476524128370901588" "False" "High" "IsMasterProtein" "P53634" "Dipeptidyl peptidase 1 OS=Homo sapiens OX=9606 GN=CTSC PE=1 SV=2" "0.000" "False" "27.791" "17" "5" "9" "5" "463" "51.8" "6.99" "36.80" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08773" "1075" "ENSG00000109861" "CTSC" "A8K7V2; B5MDD5; hsa:1075; P53634; Q2HIY8; Q53G93; Q71E75; Q71E76; Q7M4N9; Q7Z3G7; Q7Z5U7; Q8WY99; Q8WYA7; Q8WYA8" "" "Neutrophil degranulation; MHC class II antigen presentation; COPII-mediated vesicle transport; Cargo concentration in the ER" "4" "0" "1.033" "1.036" "1.013" "1.073" "1.059" "1.017" "1.059" "1.161" "0.913" "481.3" "497.1" "498.6" "487.7" "516.3" "509.5" "489.3" "509.6" "559.0" "439.6" "" "" "" "" "" "" "" "" "" "" "432.7" "402.2" "451.0" "476.0" "426.1" "509.5" "366.4" "450.1" "500.2" "156.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "34707929049350531" "False" "High" "IsMasterProtein" "P51151" "Ras-related protein Rab-9A OS=Homo sapiens OX=9606 GN=RAB9A PE=1 SV=1" "0.000" "False" "27.761" "42" "6" "9" "6" "201" "22.8" "5.47" "34.32" "6" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "9367" "ENSG00000123595" "RAB9A" "A8K390; hsa:9367; P51151; Q6ICN1" "Ebola virus infection in host; Measles virus infection" "RAB geranylgeranylation; RAB GEFs exchange GTP for GDP on RABs; Retrograde transport at the Trans-Golgi-Network; RHOBTB3 ATPase cycle" "6" "0" "0.930" "0.917" "0.984" "0.975" "0.922" "0.936" "0.958" "0.909" "0.722" "523.6" "486.9" "480.3" "515.2" "510.5" "482.8" "490.1" "501.7" "475.8" "378.0" "" "" "" "" "" "" "" "" "" "" "470.8" "394.0" "434.5" "502.9" "421.3" "482.8" "367.0" "443.2" "425.7" "134.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1696656026908675474" "False" "High" "IsMasterProtein" "Q9BS40" "Latexin OS=Homo sapiens OX=9606 GN=LXN PE=1 SV=2" "0.000" "False" "27.730" "36" "5" "7" "5" "222" "25.7" "5.78" "31.69" "5" "stress response;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity;other molecular function" "Pf06907, Pf20630" "56925" "ENSG00000079257" "LXN" "hsa:56925; Q96PN2; Q9BS40; Q9NQS6" "" "" "0" "0" "1.047" "1.098" "0.961" "1.082" "1.006" "1.004" "1.017" "0.983" "1.058" "660.9" "691.7" "725.5" "635.3" "714.9" "664.7" "663.5" "672.3" "649.9" "699.6" "" "" "" "" "" "" "" "" "" "" "594.2" "559.7" "656.2" "620.1" "590.0" "664.7" "496.8" "593.8" "581.5" "249.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2612054938348296953" "False" "High" "IsMasterProtein" "Q16595" "Frataxin, mitochondrial OS=Homo sapiens OX=9606 GN=FXN PE=1 SV=2" "0.000" "False" "27.710" "30" "5" "10" "5" "210" "23.1" "8.69" "39.04" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf01491" "2395" "ENSG00000165060" "FXN" "A8MXJ6; C9JJ89; hsa:2395; O15545; O95656; Q15294; Q16595; Q5VZ01" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.918" "0.857" "1.055" "1.025" "1.008" "0.981" "1.036" "0.974" "0.731" "1090.9" "1001.0" "934.6" "1151.3" "1117.6" "1099.6" "1069.8" "1129.6" "1062.9" "797.0" "" "" "" "" "" "" "" "" "" "" "980.8" "810.0" "845.4" "1123.8" "922.3" "1099.6" "801.1" "997.8" "951.1" "284.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7603913648578901731" "False" "High" "IsMasterProtein" "Q5VWZ2" "Lysophospholipase-like protein 1 OS=Homo sapiens OX=9606 GN=LYPLAL1 PE=1 SV=3" "0.000" "False" "27.701" "32" "8" "12" "8" "237" "26.3" "7.84" "41.04" "8" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02230" "127018" "ENSG00000143353" "LYPLAL1" "A8K677; hsa:127018; Q5VWZ2; Q5VWZ3; Q7Z4A3; Q96AV0" "" "" "0" "0" "1.017" "0.976" "1.005" "1.132" "0.882" "1.031" "1.008" "0.995" "0.882" "844.5" "859.0" "824.5" "848.9" "955.6" "745.0" "871.1" "851.5" "840.5" "744.6" "" "" "" "" "" "" "" "" "" "" "759.3" "695.1" "745.8" "828.6" "788.6" "745.0" "652.3" "752.1" "752.1" "265.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7768622532908684431" "False" "High" "IsMasterProtein" "P26842" "CD27 antigen OS=Homo sapiens OX=9606 GN=CD27 PE=1 SV=2" "0.000" "False" "27.696" "23" "5" "7" "5" "260" "29.1" "7.64" "30.58" "5" "signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf00020" "939" "ENSG00000139193" "CD27" "B2RDZ0; hsa:939; P26842" "" "TNFs bind their physiological receptors" "1" "0" "0.937" "0.766" "0.973" "0.914" "0.772" "0.978" "0.954" "0.809" "0.597" "336.8" "315.6" "258.1" "327.7" "307.7" "260.1" "329.3" "321.3" "272.4" "201.1" "" "" "" "" "" "" "" "" "" "" "302.8" "255.4" "233.4" "319.8" "253.9" "260.1" "246.5" "283.8" "243.7" "71.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5768546020460865093" "False" "High" "IsMasterProtein" "O15160" "DNA-directed RNA polymerases I and III subunit RPAC1 OS=Homo sapiens OX=9606 GN=POLR1C PE=1 SV=1" "0.000" "False" "27.686" "24" "6" "9" "6" "346" "39.2" "5.50" "33.57" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01000, Pf01193" "9533" "ENSG00000171453" "POLR1C" "hsa:9533; O15160; O75395; Q5JTE3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "15" "0" "1.025" "1.094" "0.989" "0.994" "1.143" "1.095" "0.986" "1.076" "2.057" "662.0" "678.4" "723.9" "654.4" "658.1" "756.4" "725.1" "652.6" "712.1" "1361.3" "" "" "" "" "" "" "" "" "" "" "595.2" "549.0" "654.8" "638.7" "543.1" "756.4" "543.0" "576.4" "637.2" "486.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-547053484993874983" "False" "High" "IsMasterProtein" "Q13085" "Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2" "0.000" "False" "27.671" "5" "12" "12" "12" "2346" "265.4" "6.37" "39.75" "12" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus" "other molecular function" "Pf00289, Pf00364, Pf01039, Pf02785, Pf02786, Pf08326, Pf21385" "31" "ENSG00000275176; ENSG00000278540" "ACACA" "B2RP68; B2ZZ90; hsa:31; Q13085; Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3" "AMP-activated protein kinase signaling; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Fatty acid biosynthesis; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin and adiponectin; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Mitochondrial fatty acid synthesis pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; 7q11.23 copy number variation syndrome; 17q12 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; ADHD and autism (ASD) linked metabolic pathways and SNP" "ChREBP activates metabolic gene expression; Biotin transport and metabolism; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); Fatty acyl-CoA biosynthesis; Defective HLCS causes multiple carboxylase deficiency" "24" "0" "0.963" "0.981" "0.934" "0.899" "0.899" "0.933" "0.865" "1.008" "3.275" "1063.2" "1023.8" "1042.5" "992.5" "955.9" "955.9" "992.1" "920.1" "1071.2" "3481.8" "" "" "" "" "" "" "" "" "" "" "955.9" "828.4" "943.0" "968.8" "788.9" "955.9" "742.9" "812.7" "958.5" "1242.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7159093635266280091" "False" "High" "IsMasterProtein" "O95295" "SNARE-associated protein Snapin OS=Homo sapiens OX=9606 GN=SNAPIN PE=1 SV=1" "0.000" "False" "27.667" "48" "6" "9" "6" "136" "14.9" "9.31" "34.81" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14712" "23557" "ENSG00000143553" "SNAPIN" "D3DV56; hsa:23557; O95295; Q5SXU8" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "1.041" "1.052" "0.999" "1.046" "1.047" "1.063" "1.077" "1.045" "0.938" "1115.0" "1160.8" "1172.7" "1114.4" "1166.7" "1167.4" "1184.7" "1200.5" "1165.0" "1046.3" "" "" "" "" "" "" "" "" "" "" "1002.5" "939.3" "1060.8" "1087.8" "962.8" "1167.4" "887.1" "1060.4" "1042.4" "373.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "175169128914004892" "False" "High" "IsMasterProtein" "Q30154" "HLA class II histocompatibility antigen, DR beta 5 chain OS=Homo sapiens OX=9606 GN=HLA-DRB5 PE=1 SV=1" "0.000" "False" "27.662" "30" "7" "8" "4" "266" "30.0" "6.93" "34.79" "7" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3127" "ENSG00000198502" "HLA-DRB5" "B2RBV6; C7C4X3; hsa:3127; O00157; O00283; O46700; Q29703; Q29787; Q29788; Q30126; Q30150; Q30154; Q30199; Q6SJR2; Q7M2H9; Q8HWS7; Q8WLR5; Q9MY54; Q9XRX6" "Allograft rejection; Ebola virus infection in host; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Network map of SARS-CoV-2 signaling pathway" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "11" "0" "0.932" "0.806" "1.058" "0.869" "0.812" "0.871" "1.011" "0.908" "0.720" "292.8" "272.8" "235.9" "309.8" "254.4" "237.8" "255.0" "296.1" "266.0" "210.8" "" "" "" "" "" "" "" "" "" "" "263.3" "220.7" "213.4" "302.4" "209.9" "237.8" "190.9" "261.5" "238.0" "75.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755296670490160775" "False" "High" "IsMasterProtein" "Q96SB3" "Neurabin-2 OS=Homo sapiens OX=9606 GN=PPP1R9B PE=1 SV=3" "0.000" "False" "27.655" "11" "8" "8" "8" "817" "89.3" "4.97" "28.08" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00595, Pf17817" "84687" "ENSG00000108819" "PPP1R9B" "D3DTX6; hsa:84687; Q8TCR9; Q96SB3" "" "" "0" "0" "1.044" "1.144" "0.950" "1.028" "1.175" "1.053" "1.071" "1.093" "0.823" "597.3" "623.3" "683.5" "567.4" "614.1" "702.1" "629.1" "639.5" "652.6" "491.3" "" "" "" "" "" "" "" "" "" "" "537.0" "504.4" "618.3" "553.8" "506.8" "702.1" "471.1" "564.9" "583.9" "175.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6429762109324514714" "False" "High" "IsMasterProtein" "O75607" "Nucleoplasmin-3 OS=Homo sapiens OX=9606 GN=NPM3 PE=1 SV=3" "0.000" "False" "27.646" "44" "5" "10" "5" "178" "19.3" "4.63" "45.84" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03066" "10360" "ENSG00000107833" "NPM3" "hsa:10360; O75607; Q9UNY6" "" "" "0" "0" "0.995" "0.997" "0.858" "0.937" "1.159" "0.915" "0.906" "0.977" "0.896" "1021.4" "1016.0" "1017.9" "876.8" "956.7" "1183.5" "934.6" "925.3" "997.5" "914.8" "" "" "" "" "" "" "" "" "" "" "918.3" "822.1" "920.7" "855.8" "789.5" "1183.5" "699.8" "817.3" "892.6" "326.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6899043111177724007" "False" "High" "IsMasterProtein" "Q15208" "Serine/threonine-protein kinase 38 OS=Homo sapiens OX=9606 GN=STK38 PE=1 SV=1" "0.000" "False" "27.605" "17" "7" "8" "7" "465" "54.2" "7.15" "33.21" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "11329" "ENSG00000112079" "STK38" "hsa:11329; Q15208; Q503A1" "Interactome of polycomb repressive complex 2 (PRC2)" "RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "3" "0" "1.131" "1.066" "1.060" "1.133" "1.064" "1.157" "1.038" "1.041" "1.591" "432.2" "488.8" "460.7" "458.3" "489.8" "460.1" "500.2" "448.6" "449.9" "687.5" "" "" "" "" "" "" "" "" "" "" "388.6" "395.5" "416.7" "447.3" "404.2" "460.1" "374.6" "396.2" "402.5" "245.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2714329419910624829" "False" "High" "IsMasterProtein" "P47985" "Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRFS1 PE=1 SV=2" "0.000" "False" "27.605" "28" "7" "11" "7" "274" "29.6" "8.32" "46.58" "7" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00355, Pf02921, Pf09165" "7386" "ENSG00000169021" "UQCRFS1" "A8K519; hsa:7386; P47985; Q6NVX5; Q9UPH2" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly; Iron metabolism disorders; Arsenic metabolism and reactive oxygen species generation" "Respiratory electron transport" "6" "0" "1.039" "1.042" "1.015" "1.062" "1.105" "0.992" "1.042" "1.064" "1.037" "609.3" "633.2" "634.7" "618.4" "647.1" "673.6" "604.4" "634.8" "648.1" "632.2" "" "" "" "" "" "" "" "" "" "" "547.8" "512.3" "574.1" "603.6" "534.0" "673.6" "452.6" "560.7" "579.9" "225.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8491275537287957660" "False" "High" "IsMasterProtein" "Q8NDD1" "Uncharacterized protein C1orf131 OS=Homo sapiens OX=9606 GN=C1orf131 PE=1 SV=4" "0.000" "False" "27.581" "26" "7" "9" "7" "293" "32.6" "9.88" "31.75" "7" "other biological processes" "nucleus;other cell component" "" "Pf15375" "128061" "ENSG00000143633" "C1orf131" "Q5TBI0; Q5TBI1; Q6P6B4; Q7Z6H5; Q8N432; Q8NDD1; Q96NM6" "" "" "0" "0" "0.861" "0.802" "0.963" "0.874" "0.843" "0.887" "0.889" "0.772" "0.594" "349.1" "300.5" "280.2" "336.3" "305.2" "294.4" "309.6" "310.3" "269.7" "207.3" "" "" "" "" "" "" "" "" "" "" "313.9" "243.2" "253.4" "328.3" "251.9" "294.4" "231.8" "274.0" "241.3" "74.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6951101032549152638" "False" "High" "IsMasterProtein" "Q9BYD3" "Large ribosomal subunit protein uL4m OS=Homo sapiens OX=9606 GN=MRPL4 PE=1 SV=1" "0.000" "False" "27.573" "30" "6" "8" "6" "311" "34.9" "9.72" "36.24" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00573" "51073" "ENSG00000105364" "MRPL4" "A6NNV7; hsa:51073; Q9BW07; Q9BYD3; Q9H4N2; Q9Y317" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.020" "1.108" "1.049" "0.962" "1.111" "1.125" "1.085" "1.059" "1.276" "148.9" "151.9" "165.1" "156.2" "143.3" "165.4" "167.5" "161.5" "157.6" "190.0" "" "" "" "" "" "" "" "" "" "" "133.9" "122.9" "149.3" "152.5" "118.2" "165.4" "125.4" "142.6" "141.1" "67.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2765435694013910926" "False" "High" "IsMasterProtein" "Q96Q15" "Serine/threonine-protein kinase SMG1 OS=Homo sapiens OX=9606 GN=SMG1 PE=1 SV=3" "0.000" "False" "27.555" "3" "10" "11" "10" "3661" "410.2" "6.46" "33.41" "10" "protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02260, Pf15785, Pf17229" "23049" "ENSG00000157106" "SMG1" "hsa:23049; O43305; Q13284; Q8NFX2; Q96Q15; Q96QV0; Q96RW3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.993" "0.998" "0.960" "1.012" "0.950" "1.050" "0.951" "1.038" "1.256" "355.0" "352.6" "354.2" "340.7" "359.3" "337.2" "372.8" "337.6" "368.4" "445.9" "" "" "" "" "" "" "" "" "" "" "319.1" "285.3" "320.4" "332.6" "296.5" "337.2" "279.1" "298.2" "329.6" "159.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2170038667873591835" "False" "High" "IsMasterProtein" "O15027" "Protein transport protein Sec16A OS=Homo sapiens OX=9606 GN=SEC16A PE=1 SV=4" "0.000" "False" "27.507" "5" "10" "10" "10" "2357" "251.7" "5.80" "36.75" "10" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "" "Pf12931, Pf12932" "9919" "ENSG00000148396" "SEC16A" "A1YCA4; hsa:9919; J3KNL6; O15027; Q4G0D7; Q5SXP0; Q5SXP1; Q8N347; Q96HP1" "" "COPII-mediated vesicle transport" "1" "0" "0.942" "0.967" "0.943" "0.980" "0.952" "0.946" "0.879" "0.948" "1.014" "446.2" "420.4" "431.6" "420.9" "437.3" "424.7" "422.2" "392.2" "423.1" "452.3" "" "" "" "" "" "" "" "" "" "" "401.2" "340.1" "390.4" "410.9" "360.8" "424.7" "316.1" "346.4" "378.6" "161.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9136982351856623934" "False" "High" "IsMasterProtein" "P01861" "Immunoglobulin heavy constant gamma 4 OS=Homo sapiens OX=9606 GN=IGHG4 PE=1 SV=2" "0.000" "False" "27.475" "18" "6" "9" "6" "396" "43.8" "6.24" "34.72" "6" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "" "ENSG00000211892; ENSG00000277016" "IGHG4" "A0A286YFJ8; P01861" "" "Initial triggering of complement; Classical antibody-mediated complement activation; FCGR activation; Regulation of actin dynamics for phagocytic cup formation; Role of phospholipids in phagocytosis; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Regulation of Complement cascade; Interleukin-4 and Interleukin-13 signaling" "9" "0" "0.897" "0.952" "1.053" "0.924" "1.032" "0.939" "1.002" "0.932" "0.707" "736.9" "660.7" "701.8" "775.8" "681.1" "760.5" "691.7" "738.2" "687.1" "520.6" "" "" "" "" "" "" "" "" "" "" "662.5" "534.6" "634.8" "757.3" "562.1" "760.5" "517.9" "652.0" "614.8" "185.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4890762250346228692" "False" "High" "IsMasterProtein" "P35250" "Replication factor C subunit 2 OS=Homo sapiens OX=9606 GN=RFC2 PE=1 SV=3" "0.000" "False" "27.466" "25" "7" "8" "7" "354" "39.1" "6.44" "33.24" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00004, Pf08542" "5982" "ENSG00000049541" "RFC2" "B5BU07; D3DXG3; hsa:5982; P32846; P35250; Q9BU93" "DNA replication; Nucleotide excision repair; 7q11.23 copy number variation syndrome; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Homologous Recombination (HRR); HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress; Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "27" "0" "1.055" "1.189" "0.964" "1.095" "1.201" "1.054" "0.954" "1.223" "1.029" "543.0" "572.6" "645.6" "523.5" "594.5" "652.3" "572.5" "518.0" "664.2" "558.6" "" "" "" "" "" "" "" "" "" "" "488.2" "463.4" "584.0" "511.0" "490.6" "652.3" "428.7" "457.6" "594.3" "199.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2490332894624900384" "False" "High" "IsMasterProtein" "Q92574" "Hamartin OS=Homo sapiens OX=9606 GN=TSC1 PE=1 SV=2" "0.000" "False" "27.432" "8" "9" "9" "9" "1164" "129.7" "6.47" "22.68" "9" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04388" "7248" "ENSG00000165699" "TSC1" "B7Z897; hsa:7248; Q5VVN5; Q92574" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Glioblastoma signaling pathways; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; CAMKK2 pathway; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development" "Macroautophagy; TP53 Regulates Metabolic Genes; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "27" "0" "0.966" "1.012" "0.810" "0.851" "0.832" "0.936" "0.894" "0.830" "1.036" "1043.4" "1007.8" "1055.7" "845.5" "887.8" "868.6" "976.9" "932.5" "866.0" "1081.3" "" "" "" "" "" "" "" "" "" "" "938.1" "815.5" "954.9" "825.4" "732.7" "868.6" "731.5" "823.7" "774.9" "386.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3037731205086659877" "False" "High" "IsMasterProtein" "P09234" "U1 small nuclear ribonucleoprotein C OS=Homo sapiens OX=9606 GN=SNRPC PE=1 SV=1" "0.000" "False" "27.393" "25" "3" "9" "3" "159" "17.4" "9.67" "36.38" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06220" "6631" "ENSG00000124562" "SNRPC" "hsa:6631; P09234; Q5TAL3" "" "mRNA Splicing - Major Pathway" "1" "0" "0.863" "0.928" "0.908" "0.958" "0.992" "0.921" "0.961" "0.881" "0.889" "1117.9" "964.8" "1037.1" "1015.2" "1070.8" "1108.4" "1029.3" "1074.3" "984.6" "993.6" "" "" "" "" "" "" "" "" "" "" "1005.1" "780.7" "938.1" "990.9" "883.7" "1108.4" "770.7" "948.9" "881.0" "354.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677934760849169098" "False" "High" "IsMasterProtein" "Q8IVH4" "Methylmalonic aciduria type A protein, mitochondrial OS=Homo sapiens OX=9606 GN=MMAA PE=1 SV=1" "0.000" "False" "27.374" "20" "7" "9" "7" "418" "46.5" "9.29" "29.15" "7" "other metabolic processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf03308" "166785" "ENSG00000151611" "MMAA" "B3KX40; hsa:166785; Q495G7; Q8IVH4" "" "Propionyl-CoA catabolism; Defective MMAA causes MMA, cblA type; Defective MUT causes MMAM; Cobalamin (Cbl) metabolism" "4" "0" "1.031" "0.982" "0.979" "1.100" "1.009" "1.073" "1.061" "1.089" "0.928" "515.7" "531.5" "506.6" "504.9" "567.2" "520.5" "553.3" "547.0" "561.5" "478.7" "" "" "" "" "" "" "" "" "" "" "463.7" "430.1" "458.2" "492.9" "468.1" "520.5" "414.3" "483.1" "502.5" "170.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-599104977835536313" "False" "High" "IsMasterProtein" "P28799" "Progranulin OS=Homo sapiens OX=9606 GN=GRN PE=1 SV=2" "0.000" "False" "27.366" "12" "6" "10" "6" "593" "63.5" "6.83" "31.56" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf00396" "2896" "ENSG00000030582" "GRN" "D3DX55; hsa:2896; P23781; P23782; P23783; P23784; P28799; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0" "IL-18 signaling pathway" "Neutrophil degranulation" "2" "0" "1.000" "1.067" "0.974" "1.004" "1.112" "0.996" "1.023" "1.088" "0.995" "805.2" "805.0" "859.4" "784.4" "808.1" "895.1" "802.1" "823.9" "875.9" "801.1" "" "" "" "" "" "" "" "" "" "" "723.9" "651.4" "777.4" "765.7" "666.8" "895.1" "600.6" "727.7" "783.8" "286.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1252831994268086785" "False" "High" "IsMasterProtein" "O00268" "Transcription initiation factor TFIID subunit 4 OS=Homo sapiens OX=9606 GN=TAF4 PE=1 SV=2" "0.000" "False" "27.344" "9" "7" "8" "7" "1085" "110.0" "9.94" "29.15" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf05236, Pf07531" "6874" "ENSG00000130699" "TAF4" "A6NGD9; hsa:6874; O00268; Q5TBP6; Q99721; Q9BR40; Q9BX42" "" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "1.112" "1.124" "1.066" "1.096" "1.133" "1.145" "1.040" "1.033" "1.574" "348.8" "388.0" "392.0" "371.9" "382.2" "395.3" "399.5" "362.7" "360.2" "549.0" "" "" "" "" "" "" "" "" "" "" "313.6" "314.0" "354.6" "363.0" "315.4" "395.3" "299.1" "320.4" "322.3" "196.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340121106600756603" "False" "High" "IsMasterProtein" "Q9UPY3" "Endoribonuclease Dicer OS=Homo sapiens OX=9606 GN=DICER1 PE=1 SV=3" "0.000" "False" "27.322" "6" "10" "13" "9" "1922" "218.5" "5.68" "35.19" "10" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00636, Pf02170, Pf03368, Pf20930, Pf20931, Pf20932" "23405" "ENSG00000100697" "DICER1" "A7E2D3; B3KRG4; E0AD28; hsa:23405; O95943; Q9UPY3; Q9UQ02" "miRNA biogenesis; exRNA mechanism of action and biogenesis; Hypoxia-mediated EMT and stemness; mRNA processing; Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "M-decay: degradation of maternal mRNAs by maternally stored factors; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis" "11" "0" "1.007" "1.065" "0.949" "0.981" "0.953" "0.984" "0.870" "0.982" "1.249" "510.2" "513.8" "543.2" "484.3" "500.4" "486.0" "502.1" "443.7" "501.1" "637.2" "" "" "" "" "" "" "" "" "" "" "458.7" "415.7" "491.3" "472.8" "412.9" "486.0" "376.0" "391.9" "448.3" "227.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4340156669496060526" "False" "High" "IsMasterProtein" "Q9Y3C6" "Peptidyl-prolyl cis-trans isomerase-like 1 OS=Homo sapiens OX=9606 GN=PPIL1 PE=1 SV=1" "0.000" "False" "27.316" "36" "5" "10" "5" "166" "18.2" "7.99" "34.59" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "other molecular function" "Pf00160" "51645" "ENSG00000137168" "PPIL1" "hsa:51645; O15001; Q5TDC9; Q9Y3C6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.999" "0.993" "0.979" "1.028" "1.022" "0.959" "0.974" "0.992" "1.011" "1546.9" "1545.2" "1536.2" "1514.7" "1590.0" "1580.3" "1482.7" "1507.4" "1534.3" "1563.2" "" "" "" "" "" "" "" "" "" "" "1390.8" "1250.3" "1389.5" "1478.5" "1312.1" "1580.3" "1110.2" "1331.4" "1372.9" "558.0" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8413974576400389324" "False" "High" "IsMasterProtein" "Q9NQT5" "Exosome complex component RRP40 OS=Homo sapiens OX=9606 GN=EXOSC3 PE=1 SV=3" "0.000" "False" "27.307" "32" "6" "11" "6" "275" "29.6" "8.10" "42.12" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf15985, Pf21261, Pf21262" "51010" "ENSG00000107371" "EXOSC3" "A8K0K6; hsa:51010; Q5QP85; Q9NQT5; Q9Y3A8" "" "ATF4 activates genes in response to endoplasmic reticulum stress; Major pathway of rRNA processing in the nucleolus and cytosol; mRNA decay by 3' to 5' exoribonuclease; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "6" "0" "1.066" "1.093" "1.013" "1.086" "0.954" "1.077" "1.000" "1.023" "0.799" "532.2" "567.5" "581.8" "539.2" "577.9" "507.9" "573.4" "532.2" "544.4" "425.4" "" "" "" "" "" "" "" "" "" "" "478.5" "459.2" "526.2" "526.3" "476.9" "507.9" "429.3" "470.1" "487.2" "151.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7069915122482910766" "False" "High" "IsMasterProtein" "Q9Y2I7" "1-phosphatidylinositol 3-phosphate 5-kinase OS=Homo sapiens OX=9606 GN=PIKFYVE PE=1 SV=3" "0.000" "False" "27.305" "4" "8" "8" "8" "2098" "237.0" "6.70" "24.65" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00118, Pf00610, Pf01363, Pf01504" "200576" "ENSG00000115020" "PIKFYVE" "hsa:200576; Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67; Q9Y2I7" "" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "3" "0" "1.043" "1.065" "1.128" "0.961" "0.998" "0.939" "0.958" "0.905" "1.068" "392.4" "409.2" "418.1" "442.5" "377.2" "391.7" "368.5" "375.9" "355.3" "419.1" "" "" "" "" "" "" "" "" "" "" "352.8" "331.1" "378.2" "431.9" "311.3" "391.7" "275.9" "332.0" "317.9" "149.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2915122001344888094" "False" "High" "IsMasterProtein" "Q13136" "Liprin-alpha-1 OS=Homo sapiens OX=9606 GN=PPFIA1 PE=1 SV=1" "0.000" "False" "27.298" "9" "10" "10" "10" "1202" "135.7" "6.29" "28.72" "10" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00536, Pf07647" "8500" "ENSG00000131626; ENSG00000288198" "PPFIA1" "A6NLE3; hsa:8500; Q13135; Q13136; Q14567; Q8N4I2" "Cell lineage map for neuronal differentiation" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; Receptor-type tyrosine-protein phosphatases" "7" "0" "1.124" "1.094" "1.117" "1.126" "1.072" "1.186" "1.115" "1.032" "1.565" "446.0" "501.1" "487.9" "498.3" "502.3" "477.9" "528.8" "497.2" "460.1" "697.9" "" "" "" "" "" "" "" "" "" "" "401.0" "405.4" "441.3" "486.4" "414.5" "477.9" "395.9" "439.1" "411.7" "249.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6779909124529057950" "False" "High" "IsMasterProtein" "Q16773" "Kynurenine--oxoglutarate transaminase 1 OS=Homo sapiens OX=9606 GN=KYAT1 PE=1 SV=1" "0.000" "False" "27.294" "20" "8" "10" "7" "422" "47.8" "6.47" "36.86" "8" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00155" "883" "ENSG00000171097" "KYAT1" "hsa:883; Q16773; Q5T275; Q8N191" "" "Tryptophan catabolism; Glutamate and glutamine metabolism; Phenylalanine metabolism" "3" "0" "1.023" "1.026" "0.988" "1.043" "0.983" "0.986" "1.018" "1.055" "0.788" "468.2" "479.1" "480.6" "462.5" "488.4" "460.1" "461.4" "476.4" "494.0" "369.0" "" "" "" "" "" "" "" "" "" "" "421.0" "387.7" "434.7" "451.5" "403.1" "460.1" "345.5" "420.8" "442.0" "131.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3797665255168145849" "False" "High" "IsMasterProtein" "P46087" "28S rRNA (cytosine(4447)-C(5))-methyltransferase OS=Homo sapiens OX=9606 GN=NOP2 PE=1 SV=2" "0.000" "False" "27.287" "8" "6" "8" "6" "812" "89.2" "9.23" "28.48" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01189, Pf08062, Pf17125" "4839" "ENSG00000111641" "NOP2" "A1A4Z3; B3KPD6; hsa:4839; P46087; Q05BA7; Q0P5S5; Q3KQS4; Q58F30" "Imatinib and chronic myeloid leukemia" "rRNA modification in the nucleus and cytosol; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation" "3" "0" "1.014" "1.017" "0.978" "1.020" "1.070" "1.036" "0.944" "0.844" "0.733" "657.3" "666.3" "668.4" "642.6" "670.7" "703.3" "680.9" "620.2" "554.8" "482.1" "" "" "" "" "" "" "" "" "" "" "591.0" "539.2" "604.6" "627.2" "553.5" "703.3" "509.9" "547.8" "496.4" "172.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7478830788962877121" "False" "High" "IsMasterProtein" "Q9Y3C4" "EKC/KEOPS complex subunit TPRKB OS=Homo sapiens OX=9606 GN=TPRKB PE=1 SV=1" "0.000" "False" "27.232" "34" "4" "9" "4" "175" "19.6" "6.79" "36.11" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08617" "51002" "ENSG00000144034; ENSG00000291480" "TPRKB" "D6W5H6; hsa:51002; Q8IWR6; Q8IWR7; Q9H3K4; Q9Y3C4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.093" "1.065" "1.000" "1.161" "1.075" "1.103" "1.077" "1.091" "0.878" "408.6" "446.4" "435.0" "408.6" "474.2" "439.4" "450.7" "440.3" "445.8" "358.7" "" "" "" "" "" "" "" "" "" "" "367.4" "361.2" "393.5" "398.9" "391.4" "439.4" "337.5" "388.9" "398.9" "128.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7918100123629271451" "False" "High" "IsMasterProtein" "Q9NWV4" "CXXC motif containing zinc binding protein OS=Homo sapiens OX=9606 GN=CZIB PE=1 SV=1" "0.000" "False" "27.228" "47" "7" "12" "7" "160" "18.0" "5.01" "36.15" "7" "" "" "other molecular function" "Pf05907" "54987" "ENSG00000162384" "CZIB" "hsa:54987; Q9NWV4" "" "" "0" "0" "0.931" "0.959" "0.939" "0.939" "0.968" "0.892" "0.950" "0.952" "0.693" "1080.0" "1005.3" "1035.2" "1014.4" "1013.6" "1045.0" "963.4" "1025.8" "1027.9" "748.7" "" "" "" "" "" "" "" "" "" "" "971.1" "813.5" "936.4" "990.2" "836.5" "1045.0" "721.4" "906.0" "919.8" "267.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-397251386471415027" "False" "High" "IsMasterProtein" "Q9Y3X0" "Coiled-coil domain-containing protein 9 OS=Homo sapiens OX=9606 GN=CCDC9 PE=1 SV=1" "0.000" "False" "27.219" "14" "8" "8" "8" "531" "59.7" "5.40" "29.21" "8" "" "nucleus" "nucleic acid binding activity" "Pf15266" "26093" "ENSG00000105321" "CCDC9" "hsa:26093; Q9Y3X0" "IL-18 signaling pathway" "" "1" "0" "1.004" "1.070" "0.998" "1.128" "1.174" "1.064" "1.119" "1.070" "0.770" "351.3" "352.6" "376.0" "350.7" "396.2" "412.5" "373.7" "393.1" "376.1" "270.5" "" "" "" "" "" "" "" "" "" "" "315.9" "285.3" "340.1" "342.3" "327.0" "412.5" "279.8" "347.2" "336.5" "96.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090563644210438212" "False" "High" "IsMasterProtein" "Q6V1X1" "Dipeptidyl peptidase 8 OS=Homo sapiens OX=9606 GN=DPP8 PE=1 SV=1" "0.000" "False" "27.186" "9" "7" "10" "6" "898" "103.3" "5.80" "39.66" "7" "protein metabolism;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00326, Pf00930, Pf19520" "54878" "ENSG00000074603" "DPP8" "hsa:54878; Q6V1X1; Q7Z4C8; Q7Z4D3; Q7Z4E1; Q8IWG7; Q8NEM5; Q96JX1; Q9HBM2; Q9HBM3; Q9HBM4; Q9HBM5; Q9NXF4" "" "" "0" "0" "1.132" "1.049" "0.937" "1.254" "0.978" "1.179" "0.962" "1.071" "1.142" "567.2" "642.2" "594.8" "531.4" "711.3" "554.5" "669.0" "545.6" "607.6" "647.6" "" "" "" "" "" "" "" "" "" "" "510.0" "519.6" "538.0" "518.8" "587.0" "554.5" "500.9" "482.0" "543.6" "231.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8127793230594197368" "False" "High" "IsMasterProtein" "Q9ULH1" "Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ASAP1 PE=1 SV=4" "0.000" "False" "27.185" "8" "8" "8" "8" "1129" "125.4" "7.31" "28.54" "8" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf01412, Pf12796, Pf14604, Pf16746" "50807" "ENSG00000153317" "ASAP1" "B2RNV3; hsa:50807; Q9ULH1" "EGF/EGFR signaling pathway; CCL18 signaling pathway" "VxPx cargo-targeting to cilium" "3" "0" "1.046" "0.931" "0.978" "1.046" "1.003" "1.070" "1.026" "1.013" "1.044" "398.0" "416.1" "370.7" "389.2" "416.4" "399.1" "425.9" "408.5" "403.1" "415.7" "" "" "" "" "" "" "" "" "" "" "357.9" "336.7" "335.3" "380.0" "343.6" "399.1" "318.9" "360.8" "360.7" "148.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-329240465840991374" "False" "High" "IsMasterProtein" "Q6GMV3" "Putative peptidyl-tRNA hydrolase PTRHD1 OS=Homo sapiens OX=9606 GN=PTRHD1 PE=1 SV=1" "0.000" "False" "27.173" "43" "4" "11" "4" "140" "15.8" "9.10" "43.35" "4" "" "" "other molecular function" "Pf01981" "391356" "ENSG00000184924" "PTRHD1" "Q6GMV3" "" "" "0" "0" "0.923" "0.929" "0.932" "0.971" "0.825" "0.922" "0.964" "0.857" "0.706" "1792.1" "1654.8" "1665.5" "1669.8" "1739.8" "1478.0" "1652.3" "1727.3" "1535.2" "1265.1" "" "" "" "" "" "" "" "" "" "" "1611.3" "1339.0" "1506.5" "1629.9" "1435.7" "1478.0" "1237.2" "1525.7" "1373.7" "451.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4271689599031996441" "False" "High" "IsMasterProtein" "Q9H1K1" "Iron-sulfur cluster assembly enzyme ISCU OS=Homo sapiens OX=9606 GN=ISCU PE=1 SV=2" "0.000" "False" "27.120" "49" "7" "13" "7" "167" "18.0" "9.48" "42.43" "7" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01592" "23479" "ENSG00000136003" "ISCU" "hsa:23479; Q6P713; Q99617; Q9H1K1; Q9H1K2" "Iron-sulfur cluster biogenesis" "Maturation of replicase proteins" "2" "0" "0.946" "0.926" "1.030" "1.011" "0.902" "0.960" "0.973" "0.996" "0.811" "382.4" "361.9" "354.2" "394.0" "386.7" "345.1" "367.1" "372.2" "380.9" "310.2" "" "" "" "" "" "" "" "" "" "" "343.8" "292.8" "320.4" "384.6" "319.1" "345.1" "274.9" "328.8" "340.9" "110.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1414945439185658993" "False" "High" "IsMasterProtein" "P84090" "Enhancer of rudimentary homolog OS=Homo sapiens OX=9606 GN=ERH PE=1 SV=1" "0.000" "False" "27.100" "39" "4" "17" "4" "104" "12.3" "5.92" "48.34" "4" "cell cycle OR cell proliferation;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01133" "2079" "ENSG00000100632" "ERH" "B2R5H2; hsa:2079; P70659; P84090; Q14259" "" "" "0" "0" "0.917" "0.987" "0.944" "0.994" "0.979" "0.981" "1.079" "1.059" "0.776" "1187.5" "1089.2" "1172.5" "1121.1" "1180.9" "1162.9" "1164.8" "1280.9" "1257.3" "920.9" "" "" "" "" "" "" "" "" "" "" "1067.7" "881.3" "1060.6" "1094.3" "974.5" "1162.9" "872.2" "1131.4" "1125.1" "328.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7481599324901596636" "False" "High" "IsMasterProtein" "O75391" "Sperm-associated antigen 7 OS=Homo sapiens OX=9606 GN=SPAG7 PE=1 SV=2" "0.000" "False" "27.096" "33" "7" "9" "7" "227" "26.0" "7.91" "32.91" "7" "" "nucleus" "nucleic acid binding activity" "Pf01424" "9552" "ENSG00000091640" "SPAG7" "hsa:9552; O75391; Q96EU5" "" "" "0" "0" "0.902" "0.921" "0.972" "0.976" "1.017" "0.932" "1.015" "0.975" "0.811" "859.5" "775.5" "791.7" "835.0" "838.7" "874.1" "801.3" "872.7" "837.7" "697.3" "" "" "" "" "" "" "" "" "" "" "772.7" "627.5" "716.1" "815.1" "692.1" "874.1" "600.0" "770.8" "749.6" "248.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2715683272122769400" "False" "High" "IsMasterProtein" "Q14197" "Large ribosomal subunit protein mL62 OS=Homo sapiens OX=9606 GN=MRPL58 PE=1 SV=1" "0.000" "False" "27.092" "36" "7" "8" "7" "206" "23.6" "10.07" "27.75" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00472" "3396" "ENSG00000167862" "MRPL58" "B2RAD1; hsa:3396; Q14197; Q53HM7; Q53Y11" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.933" "0.920" "0.925" "0.968" "0.930" "0.943" "0.960" "1.001" "0.918" "902.7" "841.9" "830.4" "835.0" "873.5" "839.9" "851.3" "867.0" "904.0" "828.3" "" "" "" "" "" "" "" "" "" "" "811.6" "681.3" "751.2" "815.1" "720.9" "839.9" "637.4" "765.8" "808.9" "295.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2877167820272688386" "False" "High" "IsMasterProtein" "Q9Y3S1" "Serine/threonine-protein kinase WNK2 OS=Homo sapiens OX=9606 GN=WNK2 PE=1 SV=4" "0.000" "False" "27.070" "3" "8" "11" "2" "2297" "242.5" "6.13" "38.73" "8" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "65268" "ENSG00000165238" "WNK2" "hsa:65268; Q5VWF1; Q5VWF2; Q8IY36; Q9C0A3; Q9H3P4; Q9Y3S1" "" "Stimuli-sensing channels" "1" "0" "0.928" "0.957" "1.125" "1.045" "0.744" "1.027" "1.061" "0.958" "0.823" "77.1" "71.5" "73.7" "86.7" "80.6" "57.3" "79.2" "81.8" "73.9" "63.5" "" "" "" "" "" "" "" "" "" "" "69.3" "57.9" "66.7" "84.6" "66.5" "57.3" "59.3" "72.2" "66.1" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337623474681162042" "False" "High" "IsMasterProtein" "P18074" "General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1" "0.000" "False" "27.042" "14" "9" "10" "9" "760" "86.9" "7.15" "29.56" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf06777, Pf13307" "2068" "ENSG00000104884" "ERCC2" "hsa:2068; P18074; Q2TB78; Q2YDY2; Q7KZU6; Q8N721" "Fluoropyrimidine activity; Eukaryotic transcription initiation; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Cytosolic iron-sulfur cluster assembly; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "36" "0" "0.963" "0.990" "0.913" "1.068" "0.959" "0.933" "0.946" "1.054" "1.138" "298.4" "287.3" "295.6" "272.5" "318.6" "286.1" "278.3" "282.5" "314.4" "339.7" "" "" "" "" "" "" "" "" "" "" "268.3" "232.5" "267.4" "266.0" "262.9" "286.1" "208.4" "249.5" "281.4" "121.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4786951349264090061" "False" "High" "IsMasterProtein" "Q9P2I0" "Cleavage and polyadenylation specificity factor subunit 2 OS=Homo sapiens OX=9606 GN=CPSF2 PE=1 SV=2" "0.000" "False" "27.003" "7" "5" "7" "5" "782" "88.4" "5.11" "24.55" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07521, Pf10996, Pf13299, Pf16661" "53981" "ENSG00000165934" "CPSF2" "B3KME1; hsa:53981; Q6NSJ1; Q9H3W7; Q9P2I0" "mRNA processing" "Transport of Mature mRNA Derived from an Intronless Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.006" "1.014" "0.904" "1.002" "0.933" "1.142" "0.877" "0.913" "1.993" "486.8" "489.6" "493.9" "440.1" "488.0" "454.0" "555.9" "426.8" "444.6" "970.2" "" "" "" "" "" "" "" "" "" "" "437.7" "396.2" "446.7" "429.6" "402.7" "454.0" "416.3" "377.0" "397.8" "346.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3077097618423052072" "False" "High" "IsMasterProtein" "Q15032" "R3H domain-containing protein 1 OS=Homo sapiens OX=9606 GN=R3HDM1 PE=1 SV=3" "0.000" "False" "26.989" "10" "9" "10" "9" "1099" "120.6" "8.75" "30.22" "9" "" "" "" "Pf01424, Pf12752" "23518" "ENSG00000048991" "R3HDM1" "A8K1V0; B3KXQ9; E9PBB4; E9PG42; G5E9G8; hsa:23518; Q15032; Q8IW32" "" "" "0" "0" "1.074" "1.042" "1.064" "1.116" "1.043" "1.123" "1.035" "0.970" "1.108" "424.1" "455.4" "441.9" "451.1" "473.1" "442.1" "476.1" "438.8" "411.2" "469.8" "" "" "" "" "" "" "" "" "" "" "381.3" "368.5" "399.7" "440.3" "390.4" "442.1" "356.5" "387.5" "367.9" "167.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3627252899551957156" "False" "High" "IsMasterProtein" "Q9NSC5" "Homer protein homolog 3 OS=Homo sapiens OX=9606 GN=HOMER3 PE=1 SV=2" "0.000" "False" "26.982" "24" "7" "10" "7" "361" "39.8" "5.45" "34.35" "7" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00568" "9454" "ENSG00000051128" "HOMER3" "B2RA10; E9PCW9; hsa:9454; O14580; O95350; Q9NSB9; Q9NSC0; Q9NSC1; Q9NSC5" "PKC-gamma calcium signaling pathway in ataxia; Cell lineage map for neuronal differentiation" "Neurexins and neuroligins" "3" "0" "0.987" "1.008" "1.065" "1.014" "1.019" "1.066" "1.025" "0.999" "0.992" "746.1" "736.3" "751.9" "794.5" "756.2" "760.6" "795.2" "764.7" "745.3" "740.2" "" "" "" "" "" "" "" "" "" "" "670.8" "595.8" "680.1" "775.5" "624.1" "760.6" "595.5" "675.4" "666.9" "264.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6220946712320524294" "False" "High" "IsMasterProtein" "Q7L5D6" "Golgi to ER traffic protein 4 homolog OS=Homo sapiens OX=9606 GN=GET4 PE=1 SV=1" "0.000" "False" "26.979" "24" "8" "9" "8" "327" "36.5" "5.41" "23.98" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04190" "51608" "ENSG00000239857" "GET4" "A4D2Q1; B3KNC7; hsa:51608; Q7L5D6; Q9UFC9; Q9Y309" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.177" "1.086" "1.061" "1.232" "1.158" "1.200" "1.111" "1.197" "1.263" "597.8" "703.6" "649.0" "634.2" "736.5" "692.5" "717.5" "664.3" "715.6" "755.0" "" "" "" "" "" "" "" "" "" "" "537.5" "569.3" "587.1" "619.1" "607.8" "692.5" "537.2" "586.7" "640.3" "269.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894400129343683729" "False" "High" "IsMasterProtein" "Q9BUH6" "Protein PAXX OS=Homo sapiens OX=9606 GN=PAXX PE=1 SV=2" "0.000" "False" "26.964" "37" "6" "8" "6" "204" "21.6" "5.48" "35.22" "6" "DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf15384" "286257" "ENSG00000148362" "PAXX" "hsa:286257; Q8IY19; Q9BUH6" "" "" "0" "0" "1.097" "1.039" "1.010" "1.080" "1.141" "0.991" "1.097" "1.053" "0.581" "545.5" "598.4" "566.5" "551.2" "589.4" "622.3" "540.8" "598.3" "574.6" "316.8" "" "" "" "" "" "" "" "" "" "" "490.5" "484.2" "512.5" "538.0" "486.3" "622.3" "404.9" "528.4" "514.1" "113.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6716133539155154712" "False" "High" "IsMasterProtein" "P82650" "Small ribosomal subunit protein mS22 OS=Homo sapiens OX=9606 GN=MRPS22 PE=1 SV=1" "0.000" "False" "26.962" "23" "8" "9" "8" "360" "41.3" "7.90" "37.68" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10245" "56945" "ENSG00000175110" "MRPS22" "hsa:56945; P82650; Q9H3I1" "Primary ovarian insufficiency" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.914" "0.838" "0.922" "0.859" "0.835" "0.918" "0.807" "0.875" "1.381" "1081.4" "988.3" "906.0" "997.6" "929.5" "902.8" "992.3" "872.6" "946.2" "1493.4" "" "" "" "" "" "" "" "" "" "" "972.3" "799.7" "819.5" "973.8" "767.0" "902.8" "743.0" "770.7" "846.6" "533.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8387736998001173674" "False" "High" "IsMasterProtein" "Q969T4" "Ubiquitin-conjugating enzyme E2 E3 OS=Homo sapiens OX=9606 GN=UBE2E3 PE=1 SV=1" "0.000" "False" "26.947" "33" "5" "9" "2" "207" "22.9" "7.18" "33.80" "5" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "10477" "ENSG00000170035" "UBE2E3" "B2RAD6; D3DPG3; hsa:10477; Q5U0R7; Q7Z4W4; Q969T4" "7q11.23 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "3" "0" "1.080" "1.060" "0.956" "1.142" "0.969" "0.873" "1.010" "1.004" "1.046" "105.1" "113.5" "111.4" "100.5" "120.0" "101.9" "91.8" "106.1" "105.6" "110.0" "" "" "" "" "" "" "" "" "" "" "94.5" "91.9" "100.8" "98.1" "99.0" "101.9" "68.8" "93.7" "94.5" "39.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9154000995379348407" "False" "High" "IsMasterProtein" "Q16644" "MAP kinase-activated protein kinase 3 OS=Homo sapiens OX=9606 GN=MAPKAPK3 PE=1 SV=1" "0.000" "False" "26.946" "23" "9" "11" "6" "382" "43.0" "7.28" "38.53" "9" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7867" "ENSG00000114738" "MAPKAPK3" "B5BU67; hsa:7867; Q16644" "Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Serotonin HTR1 group and FOS pathway" "Oxidative Stress Induced Senescence; VEGFA-VEGFR2 Pathway; p38MAPK events; activated TAK1 mediates p38 MAPK activation" "7" "0" "0.888" "0.838" "1.025" "0.913" "0.779" "0.972" "0.919" "0.786" "1.130" "910.9" "809.2" "763.5" "933.2" "831.5" "710.0" "885.4" "836.8" "715.8" "1029.3" "" "" "" "" "" "" "" "" "" "" "819.0" "654.8" "690.6" "911.0" "686.2" "710.0" "663.0" "739.2" "640.5" "367.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-815619529761870657" "False" "High" "IsMasterProtein" "Q6P996" "Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PDXDC1 PE=1 SV=2" "0.000" "False" "26.944" "14" "9" "10" "9" "788" "86.7" "5.38" "22.24" "9" "other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf00282" "23042" "ENSG00000179889; ENSG00000275498" "PDXDC1" "B4DR55; B4DSL3; E7EMH5; E7EPL4; H3BNZ1; hsa:23042; O00236; Q4F6X7; Q6P996; Q6PID7; Q86YF1; Q8N4Q9; Q8TBS5" "" "" "0" "0" "0.984" "0.995" "0.994" "1.030" "1.062" "1.008" "0.945" "1.100" "4.654" "323.8" "318.7" "322.1" "321.9" "333.6" "344.0" "326.3" "306.1" "356.1" "1507.0" "" "" "" "" "" "" "" "" "" "" "291.1" "257.9" "291.3" "314.2" "275.3" "344.0" "244.3" "270.4" "318.6" "538.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2028658389890867927" "False" "High" "IsMasterProtein" "Q99708" "DNA endonuclease RBBP8 OS=Homo sapiens OX=9606 GN=RBBP8 PE=1 SV=2" "0.000" "False" "26.942" "11" "11" "13" "11" "897" "101.9" "6.30" "35.85" "11" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08573, Pf10482" "5932" "ENSG00000101773" "RBBP8" "A6NKN2; A8K8W6; E7ETY1; hsa:5932; O75371; Q8NHQ3; Q99708" "ATM signaling in development and disease" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Transcriptional Regulation by E2F6; Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through MMEJ (alt-NHEJ)" "18" "0" "1.049" "1.122" "0.924" "1.071" "1.157" "0.967" "0.927" "1.127" "1.123" "530.9" "557.1" "595.8" "490.8" "568.8" "614.2" "513.3" "492.1" "598.2" "596.2" "" "" "" "" "" "" "" "" "" "" "477.3" "450.8" "539.0" "479.1" "469.4" "614.2" "384.4" "434.7" "535.3" "212.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8772663144839085983" "False" "High" "IsMasterProtein" "O14965" "Aurora kinase A OS=Homo sapiens OX=9606 GN=AURKA PE=1 SV=3" "0.000" "False" "26.936" "29" "9" "10" "8" "403" "45.8" "9.39" "30.61" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6790" "ENSG00000087586" "AURKA" "E1P5F9; hsa:6790; O14965; O60445; O75873; Q9BQD6; Q9UPG5" "Gastric cancer network 1; EGF/EGFR signaling pathway; p53 transcriptional gene network; HDAC6 interactions in the central nervous system" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; SUMOylation of DNA replication proteins; Regulation of PLK1 Activity at G2/M Transition; AURKA Activation by TPX2; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Interaction between PHLDA1 and AURKA" "12" "0" "1.026" "1.067" "0.971" "0.924" "1.128" "0.966" "0.958" "1.064" "0.972" "867.1" "889.7" "925.2" "842.3" "800.9" "978.1" "837.8" "830.7" "922.5" "842.5" "" "" "" "" "" "" "" "" "" "" "779.6" "719.9" "836.9" "822.2" "660.9" "978.1" "627.3" "733.7" "825.5" "300.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8751597953454221886" "False" "High" "IsMasterProtein" "P09496" "Clathrin light chain A OS=Homo sapiens OX=9606 GN=CLTA PE=1 SV=1" "0.000" "False" "26.929" "22" "8" "25" "8" "248" "27.1" "4.51" "77.94" "8" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01086" "1211" "ENSG00000122705" "CLTA" "A8K4W3; B4DIN1; F5H6N3; hsa:1211; P09496; Q2XPN5; Q53XZ1" "Synaptic vesicle pathway; Ebola virus infection in host; Fragile X syndrome" "MHC class II antigen presentation; Recycling pathway of L1; Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Retrograde neurotrophin signalling; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation; Entry of Influenza Virion into Host Cell via Endocytosis; Formation of annular gap junctions" "17" "0" "0.995" "1.001" "0.944" "0.999" "1.051" "1.026" "1.105" "0.946" "0.685" "2589.2" "2576.1" "2593.1" "2443.1" "2587.6" "2721.1" "2657.2" "2862.2" "2448.6" "1772.8" "" "" "" "" "" "" "" "" "" "" "2328.0" "2084.5" "2345.5" "2384.9" "2135.4" "2721.1" "1989.7" "2528.1" "2191.0" "632.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3970443704612931563" "False" "High" "IsMasterProtein" "P36578" "Large ribosomal subunit protein uL4 OS=Homo sapiens OX=9606 GN=RPL4 PE=1 SV=5" "0.000" "False" "26.900" "16" "6" "8" "6" "427" "47.7" "11.06" "34.25" "6" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00573, Pf14374" "6124" "ENSG00000174444" "RPL4" "A8K502; hsa:6124; P36578; P39029; Q4VBR0; Q969Z9" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.898" "0.892" "0.833" "0.938" "0.892" "0.894" "0.932" "0.877" "0.753" "1008.9" "906.5" "900.2" "840.6" "946.1" "899.6" "901.9" "940.0" "884.6" "759.4" "" "" "" "" "" "" "" "" "" "" "907.1" "733.5" "814.2" "820.6" "780.8" "899.6" "675.4" "830.3" "791.6" "271.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8388783144784420231" "False" "High" "IsMasterProtein" "P82930" "Small ribosomal subunit protein mS34 OS=Homo sapiens OX=9606 GN=MRPS34 PE=1 SV=2" "0.000" "False" "26.889" "44" "8" "12" "8" "218" "25.6" "9.98" "35.91" "8" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf16053" "65993" "ENSG00000074071" "MRPS34" "hsa:65993; P82930; Q9BVI7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.165" "1.105" "1.001" "1.010" "0.943" "1.008" "1.032" "0.952" "0.988" "751.1" "874.9" "829.7" "751.5" "758.3" "707.9" "756.7" "775.2" "714.9" "741.8" "" "" "" "" "" "" "" "" "" "" "675.3" "707.9" "750.5" "733.6" "625.7" "707.9" "566.6" "684.7" "639.6" "264.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8494037614751494800" "False" "High" "IsMasterProtein" "O94900" "Thymocyte selection-associated high mobility group box protein TOX OS=Homo sapiens OX=9606 GN=TOX PE=1 SV=3" "0.000" "False" "26.866" "11" "4" "6" "3" "526" "57.5" "7.33" "31.37" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00505" "9760" "ENSG00000198846" "TOX" "hsa:9760; O94900; Q96AV5" "Mesodermal commitment pathway; Development and heterogeneity of the ILC family; Orexin receptor pathway" "" "3" "1" "0.945" "0.808" "1.022" "1.059" "0.905" "1.111" "1.084" "0.922" "0.908" "1164.0" "1099.9" "940.6" "1190.0" "1232.9" "1053.8" "1293.8" "1261.6" "1073.1" "1057.0" "" "" "" "" "" "" "" "" "" "" "1046.6" "890.0" "850.8" "1161.6" "1017.4" "1053.8" "968.8" "1114.3" "960.2" "377.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4637087941136759499" "False" "High" "IsMasterProtein" "O15126" "Secretory carrier-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=SCAMP1 PE=1 SV=2" "0.000" "False" "26.844" "26" "7" "13" "7" "338" "37.9" "7.42" "47.19" "7" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "9522" "ENSG00000085365" "SCAMP1" "hsa:9522; O15126; O43587; Q6FG23; Q96BX1; Q96QK5" "" "Neutrophil degranulation" "1" "0" "0.974" "0.914" "0.966" "0.925" "0.877" "0.990" "1.026" "0.965" "0.822" "1227.0" "1194.8" "1121.0" "1185.7" "1134.6" "1076.3" "1214.1" "1258.8" "1184.0" "1008.2" "" "" "" "" "" "" "" "" "" "" "1103.2" "966.8" "1014.0" "1157.4" "936.3" "1076.3" "909.1" "1111.8" "1059.4" "359.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1940772277811891477" "False" "High" "IsMasterProtein" "Q96PM5" "RING finger and CHY zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCHY1 PE=1 SV=1" "0.000" "False" "26.843" "29" "7" "10" "7" "261" "30.1" "6.71" "30.71" "7" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05495, Pf13639, Pf14599" "25898" "ENSG00000163743" "RCHY1" "B3KRG3; C7E541; C7E542; C7E543; D3YRV2; E7EMC8; E7ETW5; J3KPI0; Q2KN33; Q59GN7; Q86X26; Q96PM5; Q96PR5" "Measles virus infection" "Antigen processing: Ubiquitination & Proteasome degradation; Translesion Synthesis by POLH" "3" "0" "0.951" "0.999" "0.953" "0.975" "0.942" "0.946" "1.001" "0.988" "0.850" "704.3" "669.6" "703.6" "671.0" "686.7" "663.5" "666.0" "705.3" "695.8" "598.7" "" "" "" "" "" "" "" "" "" "" "633.3" "541.8" "636.5" "655.0" "566.7" "663.5" "498.7" "623.0" "622.6" "213.7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3953719107085229180" "False" "High" "IsMasterProtein" "Q9Y6K9" "NF-kappa-B essential modulator OS=Homo sapiens OX=9606 GN=IKBKG PE=1 SV=2" "0.000" "False" "26.827" "22" "9" "9" "9" "419" "48.2" "5.71" "33.38" "9" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf11577, Pf16516, Pf18414" "8517" "ENSG00000269335" "IKBKG" "hsa:8517; Q7LBY6; Q7Z7F1; Q9Y6K9" "Nucleotide-binding oligomerization domain (NOD) pathway; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; ATM signaling in development and disease ; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Hepatitis B infection; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Network map of SARS-CoV-2 signaling pathway; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; MAP3K8 (TPL2)-dependent MAPK1/3 activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; activated TAK1 mediates p38 MAPK activation; Ovarian tumor domain proteases; PKR-mediated signaling; RIP-mediated NFkB activation via ZBP1; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; SUMOylation of immune response proteins" "76" "0" "1.023" "1.055" "1.009" "1.046" "1.051" "1.027" "1.070" "1.086" "1.138" "515.6" "527.3" "543.7" "520.4" "539.3" "542.1" "529.5" "551.9" "560.0" "586.8" "" "" "" "" "" "" "" "" "" "" "463.5" "426.7" "491.8" "508.0" "445.0" "542.1" "396.5" "487.5" "501.1" "209.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706468280429092974" "False" "High" "IsMasterProtein" "Q9Y3S2" "Zinc finger protein 330 OS=Homo sapiens OX=9606 GN=ZNF330 PE=1 SV=1" "0.000" "False" "26.799" "27" "7" "11" "7" "320" "36.2" "6.16" "26.94" "7" "" "nucleus;other cell component" "other molecular function" "Pf06524" "27309" "ENSG00000109445" "ZNF330" "B2RDA3; hsa:27309; Q9Y3S2" "" "" "0" "0" "0.943" "0.926" "0.959" "0.947" "1.023" "0.922" "0.977" "1.063" "1.346" "309.9" "292.3" "286.9" "297.2" "293.3" "317.1" "285.9" "302.8" "329.4" "417.0" "" "" "" "" "" "" "" "" "" "" "278.6" "236.5" "259.5" "290.1" "242.1" "317.1" "214.1" "267.5" "294.8" "148.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2769790673461720299" "False" "High" "IsMasterProtein" "Q96DF8" "Splicing factor ESS-2 homolog OS=Homo sapiens OX=9606 GN=ESS2 PE=1 SV=1" "0.000" "False" "26.789" "23" "8" "9" "8" "476" "52.5" "7.56" "34.75" "8" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "" "Pf09751" "8220" "ENSG00000100056" "ESS2" "hsa:8220; Q49AH7; Q96DF8; Q9BTZ4" "22q11.2 copy number variation syndrome" "" "1" "0" "1.070" "0.998" "1.060" "0.908" "1.305" "1.135" "1.011" "0.814" "1.122" "252.9" "270.7" "252.4" "268.0" "229.5" "330.1" "287.0" "255.8" "205.9" "283.9" "" "" "" "" "" "" "" "" "" "" "227.4" "219.0" "228.3" "261.6" "189.4" "330.1" "214.9" "225.9" "184.2" "101.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "315483607845859686" "False" "High" "IsMasterProtein" "Q9BRF8" "Serine/threonine-protein phosphatase CPPED1 OS=Homo sapiens OX=9606 GN=CPPED1 PE=1 SV=3" "0.000" "False" "26.773" "25" "6" "9" "6" "314" "35.5" "6.20" "35.96" "6" "" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf00149" "55313" "ENSG00000103381" "CPPED1" "B4DQ68; hsa:55313; Q6MZY9; Q9BRF8; Q9H9M9; Q9NUT6" "" "Neutrophil degranulation" "1" "0" "1.059" "1.032" "1.096" "1.184" "1.096" "1.086" "0.924" "1.081" "0.896" "475.8" "503.8" "490.9" "521.6" "563.4" "521.5" "516.7" "439.8" "514.1" "426.3" "" "" "" "" "" "" "" "" "" "" "427.8" "407.6" "444.0" "509.1" "464.9" "521.5" "386.9" "388.4" "460.0" "152.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6634047056467408227" "False" "High" "IsMasterProtein" "P62318" "Small nuclear ribonucleoprotein Sm D3 OS=Homo sapiens OX=9606 GN=SNRPD3 PE=1 SV=1" "0.000" "False" "26.684" "48" "4" "8" "4" "126" "13.9" "10.32" "33.20" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "6634" "ENSG00000100028" "SNRPD3" "B4DJP7; B5BU13; hsa:6634; P43331; P62318" "mRNA processing" "mRNA Splicing - Major Pathway; RNA Polymerase II Transcription Termination; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.039" "1.022" "0.925" "1.073" "1.032" "1.004" "0.972" "0.912" "0.896" "619.7" "643.9" "633.6" "573.5" "664.9" "639.4" "622.1" "602.6" "564.9" "555.0" "" "" "" "" "" "" "" "" "" "" "557.2" "521.0" "573.1" "559.8" "548.7" "639.4" "465.8" "532.2" "505.5" "198.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403678717829717744" "False" "High" "IsMasterProtein" "Q9H3K6" "BolA-like protein 2 OS=Homo sapiens OX=9606 GN=BOLA2B PE=1 SV=1" "0.000" "False" "26.680" "59" "4" "17" "4" "86" "10.1" "6.52" "62.55" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01722" "552900; 654483" "ENSG00000169627; ENSG00000183336" "BOLA2; BOLA2B" "A1L454; A7YDY3; hsa:552900; hsa:654483; Q9H3K6" "" "Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "1" "0" "0.969" "1.006" "0.990" "1.057" "0.961" "0.968" "1.016" "1.008" "0.925" "1315.7" "1274.8" "1323.3" "1303.1" "1391.0" "1264.1" "1274.2" "1337.3" "1326.4" "1216.7" "" "" "" "" "" "" "" "" "" "" "1183.0" "1031.5" "1197.0" "1272.0" "1147.9" "1264.1" "954.1" "1181.2" "1186.9" "434.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2208639490373230766" "False" "High" "IsMasterProtein" "Q92882" "Osteoclast-stimulating factor 1 OS=Homo sapiens OX=9606 GN=OSTF1 PE=1 SV=2" "0.000" "False" "26.664" "41" "6" "9" "6" "214" "23.8" "5.68" "35.44" "6" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00018, Pf12796" "26578" "ENSG00000134996" "OSTF1" "hsa:26578; Q5W126; Q92882; Q96IJ4" "" "Neutrophil degranulation" "1" "0" "0.946" "0.908" "1.081" "1.053" "0.988" "1.071" "1.010" "0.988" "1.011" "312.3" "295.6" "283.4" "337.7" "328.7" "308.7" "334.4" "315.3" "308.5" "315.6" "" "" "" "" "" "" "" "" "" "" "280.8" "239.2" "256.4" "329.6" "271.3" "308.7" "250.4" "278.5" "276.0" "112.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680509665028242989" "False" "High" "IsMasterProtein" "Q58FF3" "Putative endoplasmin-like protein OS=Homo sapiens OX=9606 GN=HSP90B2P PE=5 SV=1" "0.000" "False" "26.655" "15" "9" "16" "1" "399" "45.8" "5.26" "49.60" "9" "protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf00183" "" "" "HSP90B2P" "Q58FF3" "" "" "0" "0" "1.012" "1.049" "0.902" "1.046" "0.926" "1.047" "1.110" "0.941" "1.038" "59.7" "60.4" "62.6" "53.8" "62.4" "55.3" "62.5" "66.3" "56.2" "62.0" "" "" "" "" "" "" "" "" "" "" "53.7" "48.9" "56.7" "52.6" "51.5" "55.3" "46.8" "58.5" "50.3" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3553931004733427798" "False" "High" "IsMasterProtein" "P62306" "Small nuclear ribonucleoprotein F OS=Homo sapiens OX=9606 GN=SNRPF PE=1 SV=1" "0.000" "False" "26.655" "34" "4" "18" "4" "86" "9.7" "4.67" "47.35" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "6636" "ENSG00000139343" "SNRPF" "A2VCR2; B2R498; hsa:6636; P62306; Q15356; Q6IBQ1; Q6P4I0" "mRNA processing" "snRNP Assembly; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "0.985" "1.105" "1.022" "1.067" "1.127" "0.991" "0.992" "1.143" "0.832" "751.5" "740.2" "830.3" "767.7" "802.1" "846.7" "745.0" "745.7" "859.3" "624.9" "" "" "" "" "" "" "" "" "" "" "675.7" "599.0" "751.0" "749.4" "661.9" "846.7" "557.8" "658.6" "768.9" "223.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1961832364316848105" "False" "High" "IsMasterProtein" "Q9NVM4" "Protein arginine N-methyltransferase 7 OS=Homo sapiens OX=9606 GN=PRMT7 PE=1 SV=1" "0.000" "False" "26.646" "15" "8" "11" "8" "692" "78.4" "5.57" "37.55" "8" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf06325" "54496" "ENSG00000132600" "PRMT7" "B3KPR0; B3KUG9; B4E379; hsa:54496; Q96PV5; Q9H9L0; Q9NVM4" "Nitric oxide metabolism in cystic fibrosis" "RMTs methylate histone arginines" "2" "0" "1.004" "0.980" "0.966" "1.044" "1.025" "1.091" "0.938" "1.102" "1.110" "894.9" "898.9" "877.1" "864.1" "934.3" "917.3" "976.0" "839.2" "986.0" "993.0" "" "" "" "" "" "" "" "" "" "" "804.6" "727.3" "793.4" "843.5" "771.0" "917.3" "730.8" "741.2" "882.3" "354.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1403066018753267541" "False" "High" "IsMasterProtein" "Q96RU3" "Formin-binding protein 1 OS=Homo sapiens OX=9606 GN=FNBP1 PE=1 SV=2" "0.000" "False" "26.643" "16" "8" "8" "8" "617" "71.3" "5.72" "33.43" "8" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "23048" "ENSG00000187239" "FNBP1" "B7ZL12; E9PGQ4; hsa:23048; O60301; Q3MIN8; Q5TC87; Q5TC88; Q6P658; Q7LGG2; Q96RU3; Q9H8H8; Q9NWD1" "" "Clathrin-mediated endocytosis; CDC42 GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle" "5" "0" "0.852" "0.880" "0.973" "0.913" "0.783" "1.055" "0.834" "0.831" "2.277" "733.7" "624.8" "645.6" "714.2" "669.8" "574.8" "773.9" "611.8" "609.4" "1670.6" "" "" "" "" "" "" "" "" "" "" "659.6" "505.6" "583.9" "697.2" "552.7" "574.8" "579.4" "540.4" "545.3" "596.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6449496976955696731" "False" "High" "IsMasterProtein" "Q9UHR5" "SAP30-binding protein OS=Homo sapiens OX=9606 GN=SAP30BP PE=1 SV=1" "0.000" "False" "26.634" "30" "8" "9" "8" "308" "33.9" "4.84" "31.99" "8" "other biological processes" "cytoskeleton;nucleus" "" "Pf07818" "29115" "ENSG00000161526" "SAP30BP" "B3KML7; hsa:29115; Q8N1R5; Q8TDR8; Q96D27; Q9UHR5" "" "NoRC negatively regulates rRNA expression" "1" "0" "1.045" "1.116" "1.030" "1.095" "1.005" "0.925" "1.100" "1.117" "0.992" "674.9" "705.4" "753.1" "694.9" "739.2" "678.1" "624.4" "742.5" "754.1" "669.8" "" "" "" "" "" "" "" "" "" "" "606.8" "570.8" "681.2" "678.4" "610.0" "678.1" "467.5" "655.8" "674.8" "239.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1038572201038202760" "False" "High" "IsMasterProtein" "P05114" "Non-histone chromosomal protein HMG-14 OS=Homo sapiens OX=9606 GN=HMGN1 PE=1 SV=3" "0.000" "False" "26.628" "44" "5" "19" "5" "100" "10.7" "9.60" "67.77" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3150" "ENSG00000205581" "HMGN1" "hsa:3150; P05114; Q3KQR8" "ATM signaling in development and disease ; p38 MAPK signaling pathway; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "8" "0" "1.023" "0.984" "0.889" "0.933" "1.033" "0.913" "0.943" "0.975" "0.753" "1937.2" "1981.3" "1906.9" "1721.7" "1807.1" "2000.7" "1768.5" "1827.3" "1888.9" "1458.0" "" "" "" "" "" "" "" "" "" "" "1741.7" "1603.2" "1724.8" "1680.6" "1491.2" "2000.7" "1324.2" "1614.0" "1690.1" "520.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8999845406277562527" "False" "High" "IsMasterProtein" "Q9H089" "Large subunit GTPase 1 homolog OS=Homo sapiens OX=9606 GN=LSG1 PE=1 SV=2" "0.000" "False" "26.621" "11" "7" "9" "7" "658" "75.2" "6.38" "31.68" "7" "transport" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01926" "55341" "ENSG00000041802" "LSG1" "A0JLT4; A0PJK3; A6NI18; hsa:55341; Q7L9H8; Q9H089; Q9NUK8" "" "" "0" "0" "1.117" "0.941" "0.992" "1.028" "1.027" "1.103" "0.940" "0.990" "1.741" "725.5" "810.4" "682.5" "719.8" "745.5" "745.4" "800.4" "681.7" "718.2" "1262.8" "" "" "" "" "" "" "" "" "" "" "652.3" "655.7" "617.4" "702.6" "615.2" "745.4" "599.3" "602.2" "642.7" "450.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2667466145755123608" "False" "High" "IsMasterProtein" "O75380" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS6 PE=1 SV=1" "0.000" "False" "26.621" "48" "4" "9" "4" "124" "13.7" "8.28" "42.23" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf10276" "4726" "ENSG00000145494" "NDUFS6" "hsa:4726; O75380" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.962" "1.032" "0.919" "0.978" "1.018" "0.904" "1.085" "1.031" "0.708" "444.4" "427.5" "458.6" "408.2" "434.8" "452.3" "401.6" "482.3" "458.1" "314.5" "" "" "" "" "" "" "" "" "" "" "399.5" "345.9" "414.9" "398.4" "358.8" "452.3" "300.7" "426.0" "409.9" "112.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4440624783436864340" "False" "High" "IsMasterProtein" "P01911" "HLA class II histocompatibility antigen, DRB1 beta chain OS=Homo sapiens OX=9606 GN=HLA-DRB1 PE=1 SV=2" "0.000" "False" "26.604" "35" "8" "12" "4" "266" "29.9" "7.74" "45.23" "8" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00969, Pf07654" "3123" "ENSG00000196126" "HLA-DRB1" "A0MWF2; A0N0W1; A2ICT1; A2TGX3; A4F5N0; A4ZXA5; A4ZXA6; A4ZY86; A5H000; A5HKN8; A7DZP9; A7LA26; A7UHG2; A7X5B1; A7X5B7; A7X5E0; A7X5E6; A7X5H8; A7X5J4; A7X5K7; A8K098; A8YQE9; A9JPG0; B0BK85; B0LUZ6; B0UYW1; B1GWE7; B2CR03; B2LVF9; B2NJ29; B2ZCY1; B3VTP8; B3VTQ3; B5A8Y2; B5A8Y3; B5B8U0; B5B9V5; B5B9V6; B5LZ25; B5QSK8; B6VCX2; B6VEL9; B7UDB2; B9VRA4; B9X248; C0LAB5; hsa:3123; O02876; O02930; O19585; O19717; O19718; O19739; O19788; O46699; O46793; O46872; O62869; O62889; O77969; O78047; O78210; O98212; P01911; P01912; P01914; P04229; P13758; P13759; P13760; P13761; P20039; P79545; Q06662; Q0PGR5; Q0PQ39; Q14280; Q14QT2; Q155F7; Q19AF2; Q19K86; Q1AP33; Q1G0Z9; Q1JRP3; Q1KLJ6; Q27PR6; Q27PR7; Q29673; Q29720; Q29722; Q29734; Q29770; Q29771; Q29772; Q29790; Q29792; Q29800; Q29806; Q29833; Q29874; Q29875; Q29886; Q29968; Q29974; Q29975; Q2A120; Q2HZE5; Q2L9H4; Q2LE76; Q2MF40; Q2MJA6; Q2MZ92; Q2VQU1; Q2YHQ2; Q30006; Q30108; Q30112; Q30115; Q30116; Q30117; Q30120; Q30134; Q30142; Q30145; Q30149; Q30159; Q30166; Q30167; Q30200; Q307W5; Q31636; Q32MY7; Q3HUP9; Q3KTM1; Q3LA84; Q3LA87; Q3LA88; Q3LA89; Q3LA90; Q3LA91; Q3LA92; Q3LA93; Q3LA94; Q3LA95; Q3LA96; Q3LA97; Q3LA98; Q3LA99; Q3LAA0; Q3LAA1; Q3LAA2; Q3MQ60; Q3T919; Q4PRC3; Q4PRC5; Q4VZY7; Q53IG1; Q56FN9; Q56FP1; Q56FP2; Q56FP3; Q58F52; Q5BM92; Q5EER6; Q5K3W2; Q5NDB9; Q5U9W6; Q5UBA2; Q5UT58; Q5W3L4; Q5Y7A7; Q5Y7B0; Q5Y7B9; Q5Y7E9; Q5Y7G0; Q683P7; Q6REE2; Q6T865; Q6U387; Q701T1; Q70GL2; Q70Q85; Q768U2; Q768U4; Q7M2H4; Q7YNY9; Q7YP03; Q7YP04; Q7YQ26; Q7YQA3; Q7YQA5; Q860D8; Q860D9; Q860E5; Q860H8; Q860S0; Q860Z3; Q861G6; Q861H0; Q861H4; Q861H5; Q861H7; Q861H8; Q8HWQ6; Q8MH59; Q8MH60; Q8WLU3; Q8WMA0; Q95348; Q95383; Q95389; Q95461; Q95HK1; Q95HL0; Q95HL1; Q95IE3; Q95IG2; Q95IT6; Q96HZ9; Q9BCL7; Q9BCP0; Q9BCP1; Q9BCP2; Q9BCP5; Q9BD21; Q9BD33; Q9BD40; Q9GIK5; Q9GIL5; Q9GIL6; Q9GIP3; Q9GIX8; Q9GIX9; Q9GIY0; Q9GIY1; Q9GIY2; Q9GIY3; Q9GIY4; Q9GJ25; Q9GJ56; Q9GJ57; Q9GJ58; Q9GJ60; Q9GJF8; Q9GJF9; Q9GJG0; Q9MXZ0; Q9MXZ5; Q9MY13; Q9MY45; Q9MY56; Q9MYF5; Q9TPB6; Q9TPW1; Q9TPW3; Q9TPW9; Q9TPX4; Q9TQ37; Q9TQ91; Q9TQE0; Q9UBY1; Q9UIM9; Q9UIN0; Q9XRX1; Q9XRY4; Q9XRY5; Q9Y453; Q9Y4H7" "Allograft rejection; Vitamin D receptor pathway; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex; Genes associated with the development of rheumatoid arthritis; Network map of SARS-CoV-2 signaling pathway; Cell interactions of the pancreatic cancer microenvironment; Cytokines and inflammatory response; Primary ovarian insufficiency" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "17" "2" "0.963" "0.966" "1.012" "1.026" "0.904" "0.992" "1.014" "0.960" "0.793" "1321.2" "1271.9" "1276.8" "1337.4" "1355.7" "1194.4" "1310.7" "1340.3" "1268.4" "1048.3" "" "" "" "" "" "" "" "" "" "" "1187.8" "1029.2" "1154.9" "1305.5" "1118.8" "1194.4" "981.4" "1183.8" "1135.0" "374.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7610728054593455927" "False" "High" "IsMasterProtein" "Q86SZ2" "Trafficking protein particle complex subunit 6B OS=Homo sapiens OX=9606 GN=TRAPPC6B PE=1 SV=1" "0.000" "False" "26.574" "49" "8" "10" "8" "158" "18.0" "8.68" "30.79" "8" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "122553" "ENSG00000182400" "TRAPPC6B" "B3KPS2; hsa:122553; Q5JPD6; Q86SZ2; Q86U35; Q86X35" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.981" "1.022" "0.910" "1.000" "0.974" "1.073" "0.993" "0.979" "0.750" "426.0" "417.9" "435.5" "387.4" "426.1" "414.9" "457.1" "422.9" "416.9" "319.4" "" "" "" "" "" "" "" "" "" "" "383.0" "338.2" "394.0" "378.2" "351.6" "414.9" "342.2" "373.6" "373.1" "114.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5364683920046459506" "False" "High" "IsMasterProtein" "O75340" "Programmed cell death protein 6 OS=Homo sapiens OX=9606 GN=PDCD6 PE=1 SV=1" "0.000" "False" "26.530" "36" "6" "10" "6" "191" "21.9" "5.40" "36.54" "6" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13499" "10016" "ENSG00000249915" "PDCD6" "B2RD16; E7ESR3; hsa:10016; O75340; Q2YDC2; Q5TZS0" "Epithelial to mesenchymal transition in colorectal cancer" "" "1" "0" "1.146" "1.109" "1.068" "1.186" "1.020" "1.091" "1.114" "1.055" "1.147" "621.8" "712.4" "689.8" "663.9" "737.8" "634.2" "678.6" "692.7" "656.0" "713.2" "" "" "" "" "" "" "" "" "" "" "559.1" "576.5" "624.0" "648.1" "608.8" "634.2" "508.1" "611.9" "587.0" "254.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8897927759308668761" "False" "High" "IsMasterProtein" "Q3KQV9" "UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Homo sapiens OX=9606 GN=UAP1L1 PE=1 SV=2" "0.000" "False" "26.475" "18" "10" "13" "8" "507" "57.0" "6.32" "40.65" "10" "other metabolic processes" "" "other molecular function" "Pf01704" "91373" "ENSG00000197355" "UAP1L1" "A2AMJ8; hsa:91373; Q3KQV9; Q5SPZ2; Q69YQ3; Q6ZR38" "" "" "0" "0" "1.045" "1.013" "0.974" "1.073" "1.058" "1.092" "1.002" "1.024" "1.186" "608.3" "635.5" "616.0" "592.5" "652.6" "643.8" "664.0" "609.8" "623.2" "721.5" "" "" "" "" "" "" "" "" "" "" "547.0" "514.2" "557.2" "578.4" "538.5" "643.8" "497.2" "538.6" "557.6" "257.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8399686422006739058" "False" "High" "IsMasterProtein" "O15116" "U6 snRNA-associated Sm-like protein LSm1 OS=Homo sapiens OX=9606 GN=LSM1 PE=1 SV=1" "0.000" "False" "26.474" "42" "4" "10" "4" "133" "15.2" "5.22" "47.85" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27257" "ENSG00000175324" "LSM1" "B2R5E6; hsa:27257; O15116" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.052" "0.992" "1.010" "1.258" "0.990" "1.132" "1.020" "1.063" "0.839" "876.8" "922.2" "870.1" "885.2" "1102.6" "867.8" "992.7" "893.9" "932.2" "735.2" "" "" "" "" "" "" "" "" "" "" "788.3" "746.2" "787.1" "864.1" "909.9" "867.8" "743.3" "789.6" "834.1" "262.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192519440703409270" "False" "High" "IsMasterProtein" "Q8NB37" "Glutamine amidotransferase-like class 1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=GATD1 PE=1 SV=1" "0.000" "False" "26.466" "33" "4" "6" "4" "220" "23.3" "6.61" "30.06" "4" "other metabolic processes" "other cell component" "other molecular function" "" "347862" "ENSG00000177225" "GATD1" "B7ZKW5; hsa:347862; Q2NL76; Q6ZQY0; Q8NAE0; Q8NB37" "" "" "0" "0" "0.959" "1.048" "0.960" "0.956" "1.098" "1.039" "1.000" "1.067" "0.951" "283.3" "271.7" "296.9" "272.0" "271.0" "311.0" "294.3" "283.4" "302.3" "269.3" "" "" "" "" "" "" "" "" "" "" "254.7" "219.9" "268.6" "265.6" "223.6" "311.0" "220.4" "250.3" "270.5" "96.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3427598645898203721" "False" "High" "IsMasterProtein" "O14828" "Secretory carrier-associated membrane protein 3 OS=Homo sapiens OX=9606 GN=SCAMP3 PE=1 SV=3" "0.000" "False" "26.420" "20" "4" "6" "4" "347" "38.3" "7.64" "27.03" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04144" "10067" "ENSG00000116521; ENSG00000263290" "SCAMP3" "A9Z1W6; B1AVS6; hsa:10067; O14828; O15128; Q96FR8; Q9BPY0" "" "" "0" "0" "1.143" "1.072" "1.095" "0.992" "1.066" "1.088" "1.110" "1.097" "0.847" "334.2" "381.9" "358.3" "365.8" "331.4" "356.4" "363.7" "371.1" "366.7" "283.1" "" "" "" "" "" "" "" "" "" "" "300.5" "309.0" "324.1" "357.1" "273.5" "356.4" "272.3" "327.8" "328.1" "101.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9053740260663860944" "False" "High" "IsMasterProtein" "Q9NZN8" "CCR4-NOT transcription complex subunit 2 OS=Homo sapiens OX=9606 GN=CNOT2 PE=1 SV=1" "0.000" "False" "26.419" "15" "7" "10" "7" "540" "59.7" "7.66" "29.42" "7" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf04153" "4848" "ENSG00000111596" "CNOT2" "hsa:4848; Q9H3E0; Q9NSX5; Q9NWR6; Q9NZN8; Q9P028" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.161" "1.072" "1.094" "1.148" "1.116" "1.068" "1.107" "1.141" "1.283" "602.6" "699.5" "646.0" "659.5" "692.0" "672.3" "643.9" "667.0" "687.9" "773.2" "" "" "" "" "" "" "" "" "" "" "541.8" "566.0" "584.3" "643.7" "571.0" "672.3" "482.1" "589.1" "615.5" "276.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1468233501590493710" "False" "High" "IsMasterProtein" "O60832" "H/ACA ribonucleoprotein complex subunit DKC1 OS=Homo sapiens OX=9606 GN=DKC1 PE=1 SV=3" "0.000" "False" "26.417" "18" "8" "11" "8" "514" "57.6" "9.42" "39.21" "8" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01472, Pf01509, Pf08068, Pf16198" "1736" "ENSG00000130826" "DKC1" "F5BSB3; hsa:1736; O43845; O60832; Q96G67; Q9Y505" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.978" "1.055" "0.929" "0.970" "1.083" "0.955" "0.872" "0.899" "1.043" "549.6" "537.5" "579.6" "510.4" "533.0" "595.4" "524.6" "479.3" "494.1" "573.1" "" "" "" "" "" "" "" "" "" "" "494.1" "434.9" "524.3" "498.2" "439.9" "595.4" "392.8" "423.4" "442.2" "204.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5628662921146722487" "False" "High" "IsMasterProtein" "Q9UL18" "Protein argonaute-1 OS=Homo sapiens OX=9606 GN=AGO1 PE=1 SV=3" "0.000" "False" "26.403" "11" "8" "8" "3" "857" "97.2" "9.16" "30.24" "8" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "26523" "ENSG00000092847" "AGO1" "hsa:26523; Q5TA57; Q6P4S0; Q9UL18" "Modulators of TCR signaling and T cell activation" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Transcriptional regulation by small RNAs; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "23" "0" "1.045" "1.057" "1.049" "0.974" "1.045" "0.925" "0.896" "0.925" "0.796" "116.8" "122.0" "123.4" "122.6" "113.8" "122.1" "108.0" "104.6" "108.0" "93.0" "" "" "" "" "" "" "" "" "" "" "105.0" "98.7" "111.7" "119.6" "93.9" "122.1" "80.9" "92.4" "96.6" "33.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697914900789617779" "False" "High" "IsMasterProtein" "Q7RTV0" "PHD finger-like domain-containing protein 5A OS=Homo sapiens OX=9606 GN=PHF5A PE=1 SV=1" "0.000" "False" "26.398" "62" "7" "14" "7" "110" "12.4" "8.41" "41.43" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03660" "84844" "ENSG00000100410" "PHF5A" "hsa:84844; Q7RTV0; Q9UH06" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "0.958" "1.017" "0.934" "0.940" "1.206" "1.035" "1.047" "0.963" "0.488" "1685.4" "1614.5" "1714.3" "1574.2" "1583.9" "2032.6" "1745.3" "1763.8" "1623.4" "822.6" "" "" "" "" "" "" "" "" "" "" "1515.4" "1306.4" "1550.6" "1536.7" "1307.0" "2032.6" "1306.8" "1557.9" "1452.6" "293.6" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6657686065862137180" "False" "High" "IsMasterProtein" "Q9Y371" "Endophilin-B1 OS=Homo sapiens OX=9606 GN=SH3GLB1 PE=1 SV=1" "0.000" "False" "26.396" "17" "6" "9" "6" "365" "40.8" "6.04" "36.33" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03114, Pf14604" "51100" "ENSG00000097033" "SH3GLB1" "B4E182; hsa:51100; Q5H8U5; Q9H3Z0; Q9NR47; Q9NYA9; Q9Y371" "Nanoparticle triggered autophagic cell death" "" "1" "0" "0.918" "0.964" "1.007" "0.909" "0.957" "0.983" "0.980" "0.967" "1.903" "967.5" "888.5" "932.8" "974.0" "879.4" "926.3" "950.6" "948.3" "935.7" "1841.4" "" "" "" "" "" "" "" "" "" "" "869.8" "718.9" "843.7" "950.8" "725.7" "926.3" "711.8" "837.6" "837.3" "657.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8561031833154832659" "False" "High" "IsMasterProtein" "O15379" "Histone deacetylase 3 OS=Homo sapiens OX=9606 GN=HDAC3 PE=1 SV=2" "0.000" "False" "26.354" "15" "7" "8" "6" "428" "48.8" "5.16" "28.38" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850" "8841" "ENSG00000171720" "HDAC3" "D3DQE1; hsa:8841; O15379; O43268; Q9UEI5; Q9UEV0" "Neural crest differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; Ethanol effects on histone modifications; Transcription co-factors SKI and SKIL protein partners; 22q11.2 copy number variation syndrome; IL-18 signaling pathway; 7q11.23 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; HCMV Early Events; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Heme signaling; Regulation of PTEN gene transcription; Transcriptional activation of mitochondrial biogenesis; HDACs deacetylate histones; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; NR1D1 (REV-ERBA) represses gene expression; p75NTR negatively regulates cell cycle via SC1; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; STAT3 nuclear events downstream of ALK signaling" "31" "0" "1.100" "1.052" "1.053" "1.094" "1.012" "1.049" "1.026" "0.983" "1.028" "813.3" "894.8" "855.7" "856.5" "889.4" "822.9" "853.1" "834.4" "799.3" "835.8" "" "" "" "" "" "" "" "" "" "" "731.2" "724.1" "774.0" "836.1" "733.9" "822.9" "638.8" "737.0" "715.2" "298.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9137773696009286865" "False" "High" "IsMasterProtein" "P58546" "Myotrophin OS=Homo sapiens OX=9606 GN=MTPN PE=1 SV=2" "0.000" "False" "26.347" "35" "4" "15" "4" "118" "12.9" "5.52" "54.63" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "136319" "ENSG00000105887" "MTPN" "hsa:136319; P58546" "" "" "0" "0" "0.873" "0.912" "0.850" "0.942" "0.904" "0.984" "0.941" "0.898" "0.776" "2097.5" "1831.0" "1914.0" "1782.8" "1976.3" "1896.0" "2063.6" "1972.9" "1884.1" "1628.2" "" "" "" "" "" "" "" "" "" "" "1885.9" "1481.6" "1731.2" "1740.3" "1630.8" "1896.0" "1545.2" "1742.6" "1685.9" "581.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-10968856719763814" "False" "High" "IsMasterProtein" "P62081" "Small ribosomal subunit protein eS7 OS=Homo sapiens OX=9606 GN=RPS7 PE=1 SV=1" "0.000" "False" "26.346" "42" "8" "11" "8" "194" "22.1" "10.10" "34.72" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01251" "6201" "ENSG00000171863" "RPS7" "hsa:6201; P23821; P24818; P62081; Q57Z92; Q6IPH1" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Regulation of expression of SLITs and ROBOs; SRP-dependent cotranslational protein targeting to membrane; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "20" "0" "1.025" "1.028" "0.928" "1.018" "1.050" "0.991" "0.958" "1.056" "1.024" "1189.0" "1219.0" "1222.9" "1103.1" "1210.3" "1248.3" "1178.3" "1138.6" "1255.7" "1217.8" "" "" "" "" "" "" "" "" "" "" "1069.1" "986.4" "1106.2" "1076.8" "998.8" "1248.3" "882.3" "1005.7" "1123.6" "434.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "945913478307562709" "False" "High" "IsMasterProtein" "Q9Y2Q9" "Small ribosomal subunit protein bS1m OS=Homo sapiens OX=9606 GN=MRPS28 PE=1 SV=1" "0.000" "False" "26.320" "38" "7" "9" "7" "187" "20.8" "9.10" "30.52" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10246" "28957" "ENSG00000147586" "MRPS28" "B2RDZ7; hsa:28957; Q96Q21; Q9Y2Q9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.022" "0.961" "1.013" "1.031" "1.044" "1.063" "1.085" "1.038" "0.941" "793.5" "810.8" "762.2" "803.7" "817.9" "828.3" "843.8" "860.6" "823.9" "746.3" "" "" "" "" "" "" "" "" "" "" "713.4" "656.1" "689.4" "784.5" "675.0" "828.3" "631.8" "760.2" "737.2" "266.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-123895126992999128" "False" "High" "IsMasterProtein" "Q96BR5" "Cytochrome c oxidase assembly factor 7 OS=Homo sapiens OX=9606 GN=COA7 PE=1 SV=2" "0.000" "False" "26.294" "42" "9" "9" "9" "231" "25.7" "6.02" "31.38" "9" "" "mitochondrion;nucleus" "" "Pf08238" "65260" "ENSG00000162377" "COA7" "hsa:65260; Q0P6I7; Q96BR5; Q9H9Z9" "" "" "0" "0" "0.886" "0.936" "0.941" "0.967" "0.965" "1.003" "1.010" "0.964" "0.756" "951.7" "843.0" "890.9" "895.6" "920.6" "918.4" "955.0" "961.7" "917.3" "719.6" "" "" "" "" "" "" "" "" "" "" "855.7" "682.1" "805.8" "874.3" "759.7" "918.4" "715.1" "849.5" "820.8" "256.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2149131157478544716" "False" "High" "IsMasterProtein" "Q6P587" "Oxaloacetate tautomerase FAHD1, mitochondrial OS=Homo sapiens OX=9606 GN=FAHD1 PE=1 SV=3" "0.000" "False" "26.287" "28" "5" "10" "5" "221" "24.5" "7.39" "41.06" "5" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.029" "1.004" "1.032" "1.130" "1.011" "1.052" "1.007" "1.046" "0.854" "640.4" "659.2" "643.3" "660.6" "723.7" "647.6" "673.8" "644.7" "669.8" "546.9" "" "" "" "" "" "" "" "" "" "" "575.8" "533.4" "581.9" "644.9" "597.2" "647.6" "504.5" "569.5" "599.3" "195.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1756895692335459560" "False" "High" "IsMasterProtein" "O95865" "Putative hydrolase DDAH2 OS=Homo sapiens OX=9606 GN=DDAH2 PE=1 SV=1" "0.000" "False" "26.278" "27" "7" "9" "7" "285" "29.6" "6.01" "34.55" "7" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "" "23564" "ENSG00000206395; ENSG00000213722; ENSG00000225635; ENSG00000226634; ENSG00000227317; ENSG00000228128; ENSG00000233076" "DDAH2" "A2BEZ7; hsa:23564; O95865" "Nitric oxide metabolism in cystic fibrosis" "" "1" "0" "1.005" "1.095" "1.043" "1.007" "1.106" "1.080" "1.002" "1.115" "0.852" "828.3" "832.2" "906.7" "863.9" "833.7" "916.3" "894.2" "830.0" "923.2" "705.9" "" "" "" "" "" "" "" "" "" "" "744.7" "673.4" "820.1" "843.2" "688.0" "916.3" "669.6" "733.1" "826.0" "252.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "727638957837399757" "False" "High" "IsMasterProtein" "O15014" "Zinc finger protein 609 OS=Homo sapiens OX=9606 GN=ZNF609 PE=1 SV=2" "0.000" "False" "26.278" "7" "9" "11" "8" "1411" "151.1" "8.03" "31.10" "9" "other biological processes" "nucleus" "other molecular function" "" "23060" "ENSG00000180357" "ZNF609" "hsa:23060; O15014; Q0D2I2" "" "" "0" "0" "1.024" "0.980" "0.940" "0.993" "0.924" "1.113" "1.020" "0.941" "1.085" "661.3" "677.0" "648.3" "621.6" "656.7" "611.0" "736.2" "674.6" "622.3" "717.2" "" "" "" "" "" "" "" "" "" "" "594.6" "547.8" "586.4" "606.7" "541.9" "611.0" "551.3" "595.8" "556.8" "256.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853605967738796226" "False" "High" "IsMasterProtein" "Q13137" "Calcium-binding and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CALCOCO2 PE=1 SV=1" "0.000" "False" "26.268" "19" "9" "9" "9" "446" "52.2" "5.02" "30.89" "9" "other metabolic processes;stress response;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf17751" "10241" "ENSG00000136436" "CALCOCO2" "B2RBT0; B4DDC4; B4DDT4; B4DP36; B4E0C0; E7ENK0; E7ETP5; E9PBE5; hsa:10241; Q13137; Q53FQ5; Q53HB5; Q6IBN9; Q9BTF7" "" "" "0" "0" "0.998" "1.007" "0.976" "0.990" "0.978" "0.987" "0.981" "0.989" "0.963" "1414.5" "1411.8" "1423.7" "1380.4" "1400.3" "1383.0" "1396.3" "1386.9" "1398.4" "1362.5" "" "" "" "" "" "" "" "" "" "" "1271.8" "1142.4" "1287.8" "1347.5" "1155.6" "1383.0" "1045.5" "1225.0" "1251.3" "486.4" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6950244637905263726" "False" "High" "IsMasterProtein" "Q9Y3B4" "Splicing factor 3B subunit 6 OS=Homo sapiens OX=9606 GN=SF3B6 PE=1 SV=1" "0.000" "False" "26.252" "39" "4" "8" "4" "125" "14.6" "9.38" "29.12" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus" "nucleic acid binding activity" "Pf00076" "51639" "ENSG00000115128" "SF3B6" "hsa:51639; Q53TM1; Q9Y3B4" "" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "2" "0" "0.855" "0.849" "0.948" "0.835" "0.852" "0.943" "0.830" "0.760" "1.344" "950.9" "812.8" "807.6" "901.1" "793.7" "810.2" "896.6" "789.7" "722.7" "1277.8" "" "" "" "" "" "" "" "" "" "" "854.9" "657.7" "730.5" "879.6" "655.0" "810.2" "671.4" "697.5" "646.7" "456.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4822956659812595428" "False" "High" "IsMasterProtein" "P17706" "Tyrosine-protein phosphatase non-receptor type 2 OS=Homo sapiens OX=9606 GN=PTPN2 PE=1 SV=2" "0.000" "False" "26.249" "24" "10" "12" "10" "415" "48.4" "8.29" "36.68" "10" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5771" "ENSG00000175354" "PTPN2" "A8K955; A8MXU3; hsa:5771; K7ENG3; P17706; Q96AU5; Q96HR2" "Immune response to tuberculosis; 5q35 copy number variation" "PKR-mediated signaling; Negative regulation of MET activity; Interleukin-37 signaling" "5" "0" "1.028" "0.959" "0.949" "1.028" "0.939" "1.064" "1.070" "0.935" "1.020" "417.6" "429.2" "400.2" "396.1" "429.4" "391.9" "444.3" "446.9" "390.5" "426.1" "" "" "" "" "" "" "" "" "" "" "375.4" "347.3" "362.0" "386.7" "354.3" "391.9" "332.7" "394.7" "349.5" "152.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827826663467104318" "False" "High" "IsMasterProtein" "Q9UK41" "Vacuolar protein sorting-associated protein 28 homolog OS=Homo sapiens OX=9606 GN=VPS28 PE=1 SV=1" "0.000" "False" "26.235" "34" "7" "10" "7" "221" "25.4" "5.54" "32.45" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03997" "51160" "ENSG00000160948; ENSG00000285339" "VPS28" "hsa:51160; Q86VK0; Q9UK41" "7q11.23 copy number variation syndrome" "HCMV Late Events; Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); Late endosomal microautophagy" "6" "0" "1.022" "1.041" "1.023" "1.069" "1.057" "1.064" "1.056" "1.045" "1.143" "667.0" "681.7" "694.5" "682.4" "713.2" "705.2" "709.8" "704.4" "696.8" "762.1" "" "" "" "" "" "" "" "" "" "" "599.7" "551.6" "628.2" "666.1" "588.5" "705.2" "531.5" "622.2" "623.5" "272.1" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1297378894876740813" "False" "High" "IsMasterProtein" "Q16854" "Deoxyguanosine kinase, mitochondrial OS=Homo sapiens OX=9606 GN=DGUOK PE=1 SV=2" "0.000" "False" "26.224" "26" "6" "10" "6" "277" "32.0" "8.66" "36.03" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01712" "1716" "ENSG00000114956" "DGUOK" "hsa:1716; P78532; Q16759; Q16854; Q4ZG09; Q7L1W9; Q96BC1" "Genetic causes of porto-sinusoidal vascular disease" "Purine salvage" "2" "0" "1.086" "1.030" "1.037" "1.103" "0.983" "1.002" "1.065" "1.003" "0.795" "1165.1" "1265.6" "1199.8" "1208.3" "1285.2" "1145.7" "1167.6" "1240.6" "1168.9" "926.0" "" "" "" "" "" "" "" "" "" "" "1047.5" "1024.0" "1085.2" "1179.4" "1060.6" "1145.7" "874.3" "1095.7" "1045.9" "330.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-849081801659546262" "False" "High" "IsMasterProtein" "P30533" "Alpha-2-macroglobulin receptor-associated protein OS=Homo sapiens OX=9606 GN=LRPAP1 PE=1 SV=1" "0.000" "False" "26.208" "22" "9" "11" "9" "357" "41.4" "8.78" "33.05" "9" "transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06400, Pf06401" "4043" "ENSG00000163956" "LRPAP1" "D3DVR9; hsa:4043; P30533; Q2M310; Q53HQ3; Q53HS6" "Cholesterol metabolism" "" "1" "0" "0.904" "0.968" "0.923" "0.990" "0.983" "0.977" "1.032" "0.983" "0.763" "1636.9" "1479.0" "1584.1" "1510.2" "1620.2" "1609.1" "1598.6" "1689.3" "1609.4" "1249.1" "" "" "" "" "" "" "" "" "" "" "1471.7" "1196.8" "1432.9" "1474.1" "1337.0" "1609.1" "1197.0" "1492.1" "1440.0" "445.9" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4672476971480337418" "False" "High" "IsMasterProtein" "P67870" "Casein kinase II subunit beta OS=Homo sapiens OX=9606 GN=CSNK2B PE=1 SV=1" "0.000" "False" "26.202" "38" "6" "12" "6" "215" "24.9" "5.55" "46.39" "6" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf01214" "1460" "ENSG00000204435; ENSG00000206406; ENSG00000224398; ENSG00000224774; ENSG00000228875; ENSG00000230700; ENSG00000232960" "CSNK2B" "B0UXA9; hsa:1460; P07312; P13862; P67870; Q4VX47" "Alzheimer's disease and miRNA effects; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Measles virus infection; Pleural mesothelioma; Alzheimer's disease; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Condensation of Prometaphase Chromosomes; KEAP1-NFE2L2 pathway; Regulation of PTEN stability and activity; Regulation of TP53 Activity through Phosphorylation; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; WNT mediated activation of DVL; Signal transduction by L1; Maturation of hRSV A proteins; Receptor Mediated Mitophagy; Synthesis of PC" "21" "0" "1.043" "1.032" "0.910" "1.036" "1.063" "1.104" "0.996" "0.990" "1.183" "437.2" "456.1" "451.2" "397.9" "452.9" "464.7" "482.5" "435.6" "432.9" "517.2" "" "" "" "" "" "" "" "" "" "" "393.1" "369.0" "408.1" "388.4" "373.7" "464.7" "361.3" "384.7" "387.3" "184.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6260636582982827540" "False" "High" "IsMasterProtein" "Q6YHU6" "tRNA (32-2'-O)-methyltransferase regulator THADA OS=Homo sapiens OX=9606 GN=THADA PE=1 SV=1" "0.000" "False" "26.162" "5" "9" "11" "9" "1953" "219.5" "6.06" "26.75" "9" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity" "Pf10350" "63892" "ENSG00000115970" "THADA" "A8K1V8; B7WNS6; hsa:63892; Q3KR04; Q53RC6; Q53TB2; Q6YHU2; Q6YHU6; Q6ZU38; Q8IY32; Q8TAU8; Q96I88; Q9BZF7; Q9C096; Q9H6U0; Q9H6W7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.028" "0.900" "0.875" "0.857" "0.903" "1.033" "0.881" "0.856" "1.199" "228.4" "234.9" "205.7" "199.9" "195.7" "206.2" "235.9" "201.4" "195.6" "273.9" "" "" "" "" "" "" "" "" "" "" "205.4" "190.1" "186.0" "195.1" "161.5" "206.2" "176.6" "177.9" "175.0" "97.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3632960594176974073" "False" "High" "IsMasterProtein" "Q9UPN9" "E3 ubiquitin-protein ligase TRIM33 OS=Homo sapiens OX=9606 GN=TRIM33 PE=1 SV=3" "0.000" "False" "26.147" "8" "8" "8" "7" "1127" "122.5" "6.67" "29.46" "8" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf00643" "51592" "ENSG00000197323" "TRIM33" "hsa:51592; O95855; Q5TG72; Q5TG73; Q5TG74; Q9C017; Q9UJ79; Q9UPN9" "Ectoderm differentiation" "Downregulation of SMAD2/3:SMAD4 transcriptional activity; Germ layer formation at gastrulation" "3" "0" "1.011" "1.037" "1.033" "0.990" "1.021" "1.153" "0.979" "1.041" "2.839" "571.9" "578.3" "593.2" "591.1" "566.2" "583.8" "659.6" "560.1" "595.4" "1623.8" "" "" "" "" "" "" "" "" "" "" "514.2" "467.9" "536.6" "577.0" "467.3" "583.8" "493.9" "494.7" "532.8" "579.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5762449723745155897" "False" "High" "IsMasterProtein" "Q9H5V9" "STING ER exit protein OS=Homo sapiens OX=9606 GN=STEEP1 PE=1 SV=1" "0.000" "False" "26.124" "30" "5" "7" "5" "222" "25.6" "8.73" "32.13" "5" "cell organization and biogenesis;transport" "cytoskeleton;nucleus;other cell component" "" "" "63932" "ENSG00000018610" "STEEP1" "A8MPX7; B4DQN2; D3DWH9; F5GWL7; hsa:63932; O43351; Q9H5V9" "" "mRNA Splicing - Major Pathway" "1" "0" "1.011" "0.953" "1.014" "0.941" "1.038" "0.970" "0.981" "0.948" "0.773" "423.1" "427.8" "403.1" "429.1" "398.1" "439.3" "410.3" "415.1" "401.3" "327.3" "" "" "" "" "" "" "" "" "" "" "380.4" "346.2" "364.6" "418.9" "328.6" "439.3" "307.2" "366.7" "359.1" "116.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8894202004243013211" "False" "High" "IsMasterProtein" "O15530" "3-phosphoinositide-dependent protein kinase 1 OS=Homo sapiens OX=9606 GN=PDPK1 PE=1 SV=1" "0.000" "False" "26.099" "17" "7" "10" "7" "556" "63.1" "7.36" "35.59" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf14593" "5170" "ENSG00000140992" "PDPK1" "H0Y4Z0; hsa:5170; O15530; Q59EH6; Q6FI20; Q8IV52; Q9BRD5" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Cardiac hypertrophic response; Focal adhesion; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; PPAR signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; ErbB signaling pathway; T-cell receptor signaling pathway; Serotonin HTR1 group and FOS pathway" "Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; GPVI-mediated activation cascade; CD28 dependent PI3K/Akt signaling; G beta:gamma signalling through PI3Kgamma; RHO GTPases activate PKNs; Activation of AKT2; Integrin signaling; RSK activation; VEGFR2 mediated vascular permeability; VEGFR2 mediated cell proliferation; Estrogen-stimulated signaling through PRKCZ; SARS-CoV-1 targets host intracellular signalling and regulatory pathways; SARS-CoV-2 targets host intracellular signalling and regulatory pathways" "46" "0" "1.055" "1.030" "0.989" "1.013" "0.965" "1.015" "0.989" "0.993" "1.146" "761.1" "803.2" "784.3" "752.5" "770.8" "734.1" "772.2" "753.1" "755.7" "872.0" "" "" "" "" "" "" "" "" "" "" "684.3" "649.9" "709.4" "734.5" "636.1" "734.1" "578.2" "665.2" "676.2" "311.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1612491288449717862" "False" "High" "IsMasterProtein" "Q13155" "Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 OS=Homo sapiens OX=9606 GN=AIMP2 PE=1 SV=2" "0.000" "False" "26.065" "31" "8" "13" "8" "320" "35.3" "8.22" "41.86" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00043, Pf16780, Pf18569" "7965" "ENSG00000106305" "AIMP2" "F8W950; hsa:7965; Q13155; Q75MR1; Q96CZ5; Q9P1L2" "Osteoclast signaling; Transcriptional activation by NRF2 in response to phytochemicals; NRF2-ARE regulation" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "5" "0" "1.004" "1.012" "0.963" "0.932" "1.026" "1.055" "0.953" "1.181" "2.751" "929.0" "932.7" "940.5" "894.9" "866.0" "953.2" "979.7" "885.7" "1097.0" "2555.4" "" "" "" "" "" "" "" "" "" "" "835.2" "754.7" "850.7" "873.6" "714.6" "953.2" "733.6" "782.3" "981.6" "912.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5208446995115017732" "False" "High" "IsMasterProtein" "Q5TFE4" "5'-nucleotidase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NT5DC1 PE=1 SV=1" "0.000" "False" "26.054" "21" "9" "9" "9" "455" "51.8" "6.35" "33.99" "9" "" "" "other molecular function" "Pf05761" "221294" "ENSG00000178425" "NT5DC1" "B2RND9; B3KR35; hsa:221294; Q5TFE4; Q6XYD5" "" "" "0" "0" "0.997" "1.000" "0.935" "1.008" "0.971" "0.971" "0.981" "1.056" "0.822" "978.6" "975.9" "978.3" "914.6" "986.2" "949.8" "949.9" "959.9" "1033.0" "804.7" "" "" "" "" "" "" "" "" "" "" "879.8" "789.6" "884.9" "892.7" "813.8" "949.8" "711.3" "847.9" "924.4" "287.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4563498728879559184" "False" "High" "IsMasterProtein" "Q9BW71" "HIRA-interacting protein 3 OS=Homo sapiens OX=9606 GN=HIRIP3 PE=1 SV=3" "0.000" "False" "26.050" "15" "7" "7" "7" "556" "61.9" "8.54" "27.17" "7" "cell organization and biogenesis" "nucleus" "" "Pf09649" "8479" "ENSG00000149929" "HIRIP3" "H3BSR3; hsa:8479; O75707; O75708; Q9BW71" "22q11.2 copy number variation syndrome; 16p11.2 proximal deletion syndrome" "" "2" "0" "0.861" "1.063" "0.894" "1.055" "1.175" "0.935" "0.958" "1.100" "0.776" "373.4" "321.6" "396.9" "334.0" "394.1" "438.9" "349.3" "357.6" "410.9" "289.7" "" "" "" "" "" "" "" "" "" "" "335.7" "260.2" "359.0" "326.0" "325.3" "438.9" "261.6" "315.9" "367.7" "103.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7687733002656654502" "False" "High" "IsMasterProtein" "P18031" "Tyrosine-protein phosphatase non-receptor type 1 OS=Homo sapiens OX=9606 GN=PTPN1 PE=1 SV=1" "0.000" "False" "26.004" "14" "6" "7" "6" "435" "49.9" "6.27" "25.57" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00102" "5770" "ENSG00000196396" "PTPN1" "hsa:5770; P18031; Q5TGD8; Q9BQV9; Q9NQQ4" "Leptin signaling pathway; Prolactin signaling pathway; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Insulin receptor recycling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Negative regulation of MET activity; Integrin signaling; MECP2 regulates neuronal receptors and channels; PTK6 Down-Regulation" "14" "0" "1.093" "0.980" "1.043" "1.053" "1.118" "1.103" "0.964" "1.033" "1.405" "205.1" "224.2" "201.0" "214.0" "216.0" "229.3" "226.2" "197.6" "211.8" "288.1" "" "" "" "" "" "" "" "" "" "" "184.4" "181.4" "181.8" "208.9" "178.2" "229.3" "169.4" "174.5" "189.5" "102.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357648313694038384" "False" "High" "IsMasterProtein" "Q8IUD2" "ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens OX=9606 GN=ERC1 PE=1 SV=1" "0.000" "False" "25.959" "8" "8" "8" "8" "1116" "128.0" "5.97" "28.21" "8" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf09457, Pf10174" "23085" "ENSG00000082805" "ERC1" "A2RU77; A7E295; D3DUP7; D3DUP8; hsa:23085; Q6NVK2; Q8IUD2; Q8IUD3; Q8IUD4; Q8IUD5; Q8NAS1; Q9NXN5; Q9UIK7; Q9UPS1" "Cell lineage map for neuronal differentiation" "" "1" "0" "0.864" "0.791" "0.883" "0.953" "0.855" "0.912" "0.855" "0.793" "1.288" "356.5" "308.1" "282.1" "314.8" "339.8" "305.0" "325.2" "304.8" "282.7" "459.2" "" "" "" "" "" "" "" "" "" "" "320.6" "249.3" "255.1" "307.3" "280.4" "305.0" "243.5" "269.2" "252.9" "163.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6971851119340033318" "False" "High" "IsMasterProtein" "Q712K3" "Ubiquitin-conjugating enzyme E2 R2 OS=Homo sapiens OX=9606 GN=UBE2R2 PE=1 SV=1" "0.000" "False" "25.935" "24" "6" "11" "5" "238" "27.1" "4.42" "36.71" "6" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "54926" "ENSG00000107341" "UBE2R2" "D3DRL5; hsa:54926; Q712K3; Q9NX64" "" "Antigen processing: Ubiquitination & Proteasome degradation; Synthesis of active ubiquitin: roles of E1 and E2 enzymes" "2" "1" "0.948" "0.897" "0.981" "0.998" "0.880" "0.979" "1.038" "0.877" "0.753" "1288.9" "1222.2" "1155.6" "1264.7" "1286.7" "1134.6" "1262.2" "1337.8" "1130.1" "970.3" "" "" "" "" "" "" "" "" "" "" "1158.9" "988.9" "1045.3" "1234.6" "1061.8" "1134.6" "945.1" "1181.6" "1011.2" "346.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7801299591553380074" "False" "High" "IsMasterProtein" "P52298" "Nuclear cap-binding protein subunit 2 OS=Homo sapiens OX=9606 GN=NCBP2 PE=1 SV=1" "0.000" "False" "25.913" "30" "6" "11" "6" "156" "18.0" "8.21" "30.72" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "22916" "ENSG00000114503" "NCBP2" "B2RE91; B4DMK7; E9PAR5; hsa:22916; P52298; Q14924; Q2TS50" "mRNA processing; 3q29 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Abortive elongation of HIV-1 transcript in the absence of Tat; RNA Polymerase II Pre-transcription Events; mRNA Capping; mRNA Splicing - Major Pathway; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; snRNP Assembly; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "29" "0" "0.984" "0.991" "1.012" "0.972" "0.871" "0.945" "1.006" "0.999" "0.963" "990.8" "975.3" "982.1" "1003.0" "963.1" "863.0" "936.5" "997.1" "989.7" "954.6" "" "" "" "" "" "" "" "" "" "" "890.9" "789.2" "888.4" "979.1" "794.8" "863.0" "701.2" "880.7" "885.6" "340.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3487009987400899106" "False" "High" "IsMasterProtein" "P13051" "Uracil-DNA glycosylase OS=Homo sapiens OX=9606 GN=UNG PE=1 SV=2" "0.000" "False" "25.903" "25" "5" "8" "5" "313" "34.6" "9.32" "36.63" "5" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion;nucleus" "translation activity;nucleic acid binding activity;other molecular function" "Pf03167" "7374" "ENSG00000076248" "UNG" "A8K5M6; B2R8Y1; hsa:7374; O00637; O00719; P13051; Q93028" "Base excision repair; DNA repair pathways, full network" "Chromatin modifications during the maternal to zygotic transition (MZT)" "3" "0" "1.015" "1.447" "0.984" "1.041" "1.512" "1.147" "0.977" "1.408" "1.132" "257.4" "261.3" "372.5" "253.2" "268.0" "389.2" "295.3" "251.4" "362.4" "291.3" "" "" "" "" "" "" "" "" "" "" "231.4" "211.5" "336.9" "247.2" "221.2" "389.2" "221.1" "222.1" "324.3" "104.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3838187860165332500" "False" "High" "IsMasterProtein" "P52564" "Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens OX=9606 GN=MAP2K6 PE=1 SV=1" "0.000" "False" "25.891" "23" "7" "7" "3" "334" "37.5" "7.39" "27.20" "7" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5608" "ENSG00000108984" "MAP2K6" "hsa:5608; P52564" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; TGF-beta signaling pathway; MAPK signaling pathway; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; 16p11.2 proximal deletion syndrome; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; GNAQ pathways in port-wine stain; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "PKR-mediated signaling; Interleukin-1 signaling; Oxidative Stress Induced Senescence; Myogenesis; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; PI5P Regulates TP53 Acetylation" "41" "0" "1.062" "0.988" "1.001" "0.994" "1.021" "0.933" "0.974" "0.939" "0.869" "143.5" "152.4" "141.7" "143.7" "142.6" "146.5" "133.9" "139.8" "134.8" "124.7" "" "" "" "" "" "" "" "" "" "" "129.0" "123.3" "128.2" "140.3" "117.7" "146.5" "100.2" "123.5" "120.6" "44.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5664998384620828706" "False" "High" "IsMasterProtein" "Q13895" "Bystin OS=Homo sapiens OX=9606 GN=BYSL PE=1 SV=3" "0.000" "False" "25.885" "19" "8" "8" "8" "437" "49.6" "8.12" "29.25" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05291" "705" "ENSG00000112578" "BYSL" "hsa:705; Q13895; Q6P5W4; Q86W44; Q96IP8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.993" "0.747" "0.931" "1.063" "0.793" "0.976" "0.941" "0.716" "1.827" "345.3" "342.8" "257.8" "321.5" "366.9" "274.0" "337.0" "325.1" "247.1" "630.8" "" "" "" "" "" "" "" "" "" "" "310.5" "277.4" "233.2" "313.8" "302.8" "274.0" "252.4" "287.1" "221.1" "225.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6802815428408388451" "False" "High" "IsMasterProtein" "Q9UK99" "F-box only protein 3 OS=Homo sapiens OX=9606 GN=FBXO3 PE=1 SV=3" "0.000" "False" "25.882" "14" "6" "7" "6" "471" "54.5" "5.00" "31.29" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00646, Pf04379, Pf09346" "26273" "ENSG00000110429" "FBXO3" "B3KY16; D3DR05; hsa:26273; Q86X90; Q9H0V2; Q9NUX2; Q9UK99" "" "" "0" "0" "0.991" "0.999" "0.980" "1.083" "0.968" "1.002" "0.966" "0.971" "0.939" "765.2" "758.3" "764.4" "750.2" "828.7" "740.6" "766.9" "739.2" "743.1" "718.5" "" "" "" "" "" "" "" "" "" "" "688.0" "613.6" "691.4" "732.3" "683.9" "740.6" "574.2" "652.9" "664.9" "256.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1368746537246451603" "False" "High" "IsMasterProtein" "Q9Y2I8" "WD repeat-containing protein 37 OS=Homo sapiens OX=9606 GN=WDR37 PE=1 SV=2" "0.000" "False" "25.875" "14" "7" "9" "7" "494" "54.6" "7.23" "34.97" "7" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "22884" "ENSG00000047056" "WDR37" "A8K976; D3DRQ7; hsa:22884; Q5SW03; Q8WVG2; Q9NTJ6; Q9Y2I8" "" "" "0" "0" "1.039" "0.972" "0.934" "1.034" "1.003" "0.986" "0.966" "0.961" "0.992" "630.1" "654.9" "612.2" "588.5" "651.6" "631.7" "621.4" "609.0" "605.8" "625.0" "" "" "" "" "" "" "" "" "" "" "566.5" "529.9" "553.8" "574.5" "537.7" "631.7" "465.3" "537.9" "542.0" "223.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6501697818920195355" "False" "High" "IsMasterProtein" "Q9Y3B9" "RRP15-like protein OS=Homo sapiens OX=9606 GN=RRP15 PE=1 SV=2" "0.000" "False" "25.853" "25" "6" "8" "6" "282" "31.5" "5.52" "28.07" "6" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "" "Pf07890" "51018" "ENSG00000067533" "RRP15" "hsa:51018; Q9Y3B9" "" "" "0" "0" "0.981" "1.026" "1.022" "1.150" "1.122" "1.077" "1.135" "1.100" "0.584" "561.8" "551.1" "576.7" "574.2" "646.1" "630.2" "605.2" "637.6" "617.8" "327.9" "" "" "" "" "" "" "" "" "" "" "505.1" "446.0" "521.6" "560.5" "533.2" "630.2" "453.1" "563.2" "552.8" "117.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8502957251701712576" "False" "High" "IsMasterProtein" "Q9UHW5" "GPN-loop GTPase 3 OS=Homo sapiens OX=9606 GN=GPN3 PE=1 SV=2" "0.000" "False" "25.824" "30" "5" "7" "5" "284" "32.7" "4.50" "28.93" "5" "" "other cell component" "other molecular function" "Pf03029" "51184" "ENSG00000111231" "GPN3" "B2RC54; D4YWV1; F5H759; hsa:51184; Q53FS3; Q6UVZ6; Q7Z3D3; Q8NEI2; Q96HK9; Q9UHW5" "" "" "0" "0" "1.083" "1.205" "1.044" "1.109" "1.115" "1.104" "1.112" "1.094" "1.461" "379.9" "411.4" "457.8" "396.7" "421.2" "423.7" "419.5" "422.7" "415.7" "555.1" "" "" "" "" "" "" "" "" "" "" "341.6" "332.9" "414.1" "387.3" "347.6" "423.7" "314.1" "373.3" "372.0" "198.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9088626010110122517" "False" "High" "IsMasterProtein" "Q9UJX6" "Anaphase-promoting complex subunit 2 OS=Homo sapiens OX=9606 GN=ANAPC2 PE=1 SV=1" "0.000" "False" "25.772" "11" "9" "12" "9" "822" "93.8" "5.22" "35.24" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00888, Pf08672" "29882" "ENSG00000176248" "ANAPC2" "hsa:29882; Q5VSG1; Q96DG5; Q96GG4; Q9P2E1; Q9UJX6" "Cell cycle" "Separation of Sister Chromatids; Senescence-Associated Secretory Phenotype (SASP); Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "1.014" "1.012" "0.915" "1.049" "0.962" "1.059" "0.971" "0.961" "1.019" "797.3" "808.7" "807.2" "729.5" "836.4" "767.0" "844.4" "774.2" "766.0" "812.6" "" "" "" "" "" "" "" "" "" "" "716.8" "654.3" "730.1" "712.1" "690.2" "767.0" "632.2" "683.9" "685.4" "290.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3062599375234318027" "False" "High" "IsMasterProtein" "Q02447" "Transcription factor Sp3 OS=Homo sapiens OX=9606 GN=SP3 PE=1 SV=3" "0.000" "False" "25.688" "11" "6" "8" "6" "781" "81.9" "5.26" "34.14" "6" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6670" "ENSG00000172845" "SP3" "A0AVL9; B4E2B7; hsa:6670; Q02447; Q69B26; Q69B27; Q8TD56; Q8WWU4; Q9BQR1" "Selenium metabolism and selenoproteins; MECP2 and associated Rett syndrome; Non-genomic actions of 1,25 dihydroxyvitamin D3; Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription factors" "5" "0" "0.929" "0.945" "1.007" "0.984" "0.915" "0.917" "0.988" "0.927" "0.913" "629.3" "584.4" "594.8" "634.0" "619.6" "575.6" "577.1" "621.7" "583.7" "574.8" "" "" "" "" "" "" "" "" "" "" "565.8" "472.9" "538.0" "618.9" "511.3" "575.6" "432.1" "549.1" "522.3" "205.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682819818401791106" "False" "High" "IsMasterProtein" "Q9NZJ0" "Denticleless protein homolog OS=Homo sapiens OX=9606 GN=DTL PE=1 SV=3" "0.000" "False" "25.677" "11" "9" "12" "9" "730" "79.4" "8.87" "30.85" "9" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "51514" "ENSG00000143476" "DTL" "A8K8H8; D3DT98; hsa:51514; Q5VT77; Q96SN0; Q9NW03; Q9NW34; Q9NWM5; Q9NZJ0" "" "Neddylation; Recognition of DNA damage by PCNA-containing replication complex" "2" "0" "0.975" "1.775" "0.933" "1.002" "1.769" "0.830" "0.911" "1.819" "1.117" "465.8" "454.3" "827.0" "434.5" "466.7" "823.9" "386.8" "424.5" "847.4" "520.4" "" "" "" "" "" "" "" "" "" "" "418.8" "367.6" "748.1" "424.1" "385.1" "823.9" "289.6" "374.9" "758.2" "185.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2256308892199755457" "False" "High" "IsMasterProtein" "Q969J3" "BLOC-1-related complex subunit 5 OS=Homo sapiens OX=9606 GN=BORCS5 PE=1 SV=1" "0.000" "False" "25.673" "36" "5" "7" "5" "196" "22.2" "6.35" "29.27" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf10158" "118426" "ENSG00000165714; ENSG00000280689" "BORCS5" "hsa:118426; Q969J3; Q96QS5" "" "" "0" "0" "0.952" "0.916" "0.945" "0.973" "0.926" "0.960" "0.965" "0.924" "0.765" "549.3" "522.7" "503.2" "519.0" "534.3" "508.8" "527.5" "530.3" "507.7" "420.0" "" "" "" "" "" "" "" "" "" "" "493.9" "422.9" "455.1" "506.6" "440.9" "508.8" "395.0" "468.4" "454.3" "149.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2282593962912776213" "False" "High" "IsMasterProtein" "Q15853" "Upstream stimulatory factor 2 OS=Homo sapiens OX=9606 GN=USF2 PE=1 SV=1" "0.000" "False" "25.612" "16" "7" "10" "4" "346" "36.9" "5.10" "29.59" "7" "transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7392" "ENSG00000105698" "USF2" "hsa:7392; O00671; O00709; Q05750; Q07952; Q15851; Q15852; Q15853; Q6FI33; Q6YI47" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "Estrogen-dependent gene expression" "2" "1" "1.042" "1.004" "1.028" "1.072" "1.034" "1.054" "1.091" "0.991" "0.985" "616.0" "641.8" "618.2" "632.9" "660.3" "636.8" "649.4" "672.2" "610.2" "606.7" "" "" "" "" "" "" "" "" "" "" "553.8" "519.4" "559.2" "617.8" "544.9" "636.8" "486.3" "593.8" "546.0" "216.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667364436417788912" "False" "High" "IsMasterProtein" "Q9BYV8" "Centrosomal protein of 41 kDa OS=Homo sapiens OX=9606 GN=CEP41 PE=1 SV=1" "0.000" "False" "25.589" "21" "6" "8" "6" "373" "41.3" "8.32" "29.57" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "cytosol;cytoskeleton;other cell component" "" "Pf00581" "95681" "ENSG00000106477" "CEP41" "A4D1M0; B4DQ35; F5H0V6; hsa:95681; Q7Z496; Q86TM1; Q8NFU8; Q9BYV8; Q9H6A3; Q9NPV3" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "10" "0" "0.874" "0.899" "1.017" "0.986" "0.905" "1.063" "0.922" "0.831" "2.148" "491.7" "429.5" "442.2" "499.9" "484.7" "444.8" "522.5" "453.4" "408.6" "1055.9" "" "" "" "" "" "" "" "" "" "" "442.0" "347.5" "400.0" "488.0" "400.0" "444.8" "391.3" "400.5" "365.6" "376.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8005883181375695291" "False" "High" "IsMasterProtein" "Q9P260" "RAB11-binding protein RELCH OS=Homo sapiens OX=9606 GN=RELCH PE=1 SV=2" "0.000" "False" "25.580" "8" "8" "8" "8" "1216" "134.5" "5.45" "25.04" "8" "transport" "ER/Golgi;other cytoplasmic organelle" "" "" "57614" "ENSG00000134444" "RELCH" "hsa:57614; Q9P260" "" "" "0" "0" "1.090" "1.030" "1.031" "1.129" "1.081" "1.122" "1.150" "1.081" "1.697" "308.3" "335.9" "317.5" "318.0" "348.0" "333.3" "345.8" "354.7" "333.3" "523.1" "" "" "" "" "" "" "" "" "" "" "277.2" "271.8" "287.2" "310.4" "287.2" "333.3" "258.9" "313.3" "298.2" "186.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8740975055967109676" "False" "High" "IsMasterProtein" "O95926" "Pre-mRNA-splicing factor SYF2 OS=Homo sapiens OX=9606 GN=SYF2 PE=1 SV=1" "0.000" "False" "25.554" "26" "6" "7" "6" "243" "28.7" "8.40" "27.07" "6" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf08231" "25949" "ENSG00000117614" "SYF2" "hsa:25949; O95926; Q5TH73" "" "mRNA Splicing - Major Pathway" "1" "0" "0.878" "0.848" "0.902" "0.926" "0.939" "0.914" "0.856" "0.882" "0.733" "722.4" "634.4" "612.6" "651.4" "668.9" "678.2" "660.0" "618.2" "637.3" "529.4" "" "" "" "" "" "" "" "" "" "" "649.5" "513.4" "554.1" "635.9" "552.0" "678.2" "494.2" "546.0" "570.2" "189.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3211480978683405727" "False" "High" "IsMasterProtein" "O95232" "Luc7-like protein 3 OS=Homo sapiens OX=9606 GN=LUC7L3 PE=1 SV=2" "0.000" "False" "25.554" "21" "9" "11" "9" "432" "51.4" "9.79" "29.28" "9" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf03194" "51747" "ENSG00000108848" "LUC7L3" "B3KN54; D3DTY1; hsa:51747; O95232; Q6PHR9; Q9NUY0; Q9P2S7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.934" "0.952" "0.916" "0.944" "0.962" "1.007" "0.950" "1.052" "0.913" "785.9" "734.0" "748.0" "720.1" "741.6" "756.0" "791.5" "746.3" "826.5" "717.8" "" "" "" "" "" "" "" "" "" "" "706.6" "593.9" "676.6" "702.9" "612.0" "756.0" "592.7" "659.2" "739.5" "256.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6935074334363071802" "False" "High" "IsMasterProtein" "O00762" "Ubiquitin-conjugating enzyme E2 C OS=Homo sapiens OX=9606 GN=UBE2C PE=1 SV=1" "0.000" "False" "25.466" "45" "5" "8" "5" "179" "19.6" "7.37" "36.38" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "11065" "ENSG00000175063" "UBE2C" "A6NP33; E1P5N7; G3XAB7; hsa:11065; O00762" "Gastric cancer network 1; Gastric cancer network 2" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "21" "0" "0.989" "1.111" "0.995" "1.098" "1.087" "1.056" "1.034" "1.072" "1.323" "923.5" "913.1" "1025.8" "918.6" "1014.1" "1003.4" "975.3" "954.9" "990.3" "1221.7" "" "" "" "" "" "" "" "" "" "" "830.3" "738.8" "927.9" "896.7" "836.8" "1003.4" "730.3" "843.4" "886.1" "436.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723353511819689268" "False" "High" "IsMasterProtein" "Q92947" "Glutaryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=GCDH PE=1 SV=1" "0.000" "False" "25.439" "15" "5" "7" "5" "438" "48.1" "8.06" "28.46" "5" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "2639" "ENSG00000105607" "GCDH" "A8K2Z2; O14719; Q92947" "Fatty acid beta-oxidation; Tryptophan metabolism" "Lysine catabolism" "3" "0" "1.046" "1.059" "0.940" "1.032" "1.043" "1.006" "1.057" "1.117" "0.805" "865.2" "905.4" "916.4" "812.9" "893.2" "902.1" "870.4" "914.2" "966.3" "696.7" "" "" "" "" "" "" "" "" "" "" "777.9" "732.6" "828.9" "793.5" "737.1" "902.1" "651.8" "807.5" "864.6" "248.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8849479475208291816" "False" "High" "IsMasterProtein" "Q9H8Y5" "tRNA endonuclease ANKZF1 OS=Homo sapiens OX=9606 GN=ANKZF1 PE=1 SV=1" "0.000" "False" "25.439" "14" "9" "9" "9" "726" "80.9" "8.41" "31.74" "9" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response" "other cell component" "other molecular function" "Pf00023, Pf18716, Pf18826" "55139" "ENSG00000163516" "ANKZF1" "hsa:55139; Q9H8Y5; Q9NVZ4" "" "" "0" "0" "0.941" "0.978" "0.973" "0.933" "0.954" "0.979" "0.905" "0.989" "1.319" "708.0" "666.0" "692.4" "689.1" "660.8" "675.4" "693.0" "640.7" "700.3" "934.2" "" "" "" "" "" "" "" "" "" "" "636.6" "538.9" "626.3" "672.7" "545.3" "675.4" "518.9" "565.9" "626.6" "333.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1498458301552967093" "False" "High" "IsMasterProtein" "P13716" "Delta-aminolevulinic acid dehydratase OS=Homo sapiens OX=9606 GN=ALAD PE=1 SV=1" "0.000" "False" "25.419" "24" "7" "10" "7" "330" "36.3" "6.79" "30.67" "7" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00490" "210" "ENSG00000148218" "ALAD" "A8K375; B2R6F2; hsa:210; P13716; Q16870; Q16871; Q9BVQ9" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Neutrophil degranulation; Heme biosynthesis" "4" "0" "1.000" "1.012" "1.019" "0.927" "0.991" "0.941" "0.997" "0.949" "0.893" "583.5" "583.6" "590.3" "594.8" "540.7" "578.0" "548.9" "581.6" "553.9" "521.0" "" "" "" "" "" "" "" "" "" "" "524.6" "472.2" "534.0" "580.6" "446.2" "578.0" "411.0" "513.7" "495.6" "186.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6535864909566568035" "False" "High" "IsMasterProtein" "O75367" "Core histone macro-H2A.1 OS=Homo sapiens OX=9606 GN=MACROH2A1 PE=1 SV=5" "0.000" "False" "25.345" "24" "7" "8" "7" "369" "39.2" "9.83" "27.41" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00125, Pf01661, Pf16211" "9555" "ENSG00000113648" "MACROH2A1" "hsa:9555; O75367; O75377; Q503A8; Q7Z5E3; Q96D41; Q9H8P3; Q9UP96" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "2" "0" "0.856" "0.888" "0.854" "0.992" "1.092" "0.766" "0.831" "0.929" "0.709" "417.3" "357.3" "370.4" "356.3" "413.8" "455.7" "319.5" "346.7" "387.8" "296.1" "" "" "" "" "" "" "" "" "" "" "375.2" "289.1" "335.1" "347.8" "341.5" "455.7" "239.3" "306.3" "347.0" "105.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485362868972298733" "False" "High" "IsMasterProtein" "P14174" "Macrophage migration inhibitory factor OS=Homo sapiens OX=9606 GN=MIF PE=1 SV=4" "0.000" "False" "25.342" "37" "3" "33" "3" "115" "12.5" "7.88" "102.99" "3" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01187" "4282" "ENSG00000240972; ENSG00000276701" "MIF" "A5Z1R8; B2R4S3; hsa:4282; P14174; Q2V4Y5; Q6FHV0" "Adipogenesis; Spinal cord injury; HDAC6 interactions in the central nervous system" "Neutrophil degranulation; Cell surface interactions at the vascular wall; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation" "6" "0" "1.005" "0.955" "0.933" "1.076" "0.978" "1.029" "1.056" "1.014" "0.801" "1629.7" "1637.2" "1557.1" "1519.9" "1753.6" "1593.0" "1677.4" "1720.6" "1651.9" "1305.2" "" "" "" "" "" "" "" "" "" "" "1465.2" "1324.7" "1408.5" "1483.6" "1447.1" "1593.0" "1256.0" "1519.8" "1478.1" "465.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974578878725693910" "False" "High" "IsMasterProtein" "P45984" "Mitogen-activated protein kinase 9 OS=Homo sapiens OX=9606 GN=MAPK9 PE=1 SV=2" "0.000" "False" "25.335" "17" "8" "9" "4" "424" "48.1" "5.63" "30.30" "8" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5601" "ENSG00000050748" "MAPK9" "A8K0S3; B5BU66; B5M0B4; D3DWQ8; D3DWQ9; hsa:5601; P45984; Q15708; Q15710; Q15711; Q8N5C5" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; ATM signaling pathway; Interleukin-1 (IL-1) structural pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; Wnt signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Wnt signaling pathway and pluripotency; Splicing factor NOVA regulated synaptic proteins; Wnt signaling in kidney disease; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; TGF-beta receptor signaling in skeletal dysplasias; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; CCL18 signaling pathway; Familial partial lipodystrophy; Alzheimer's disease; GDNF signaling; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; TGF-beta receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Toll-like receptor signaling pathway" "Oxidative Stress Induced Senescence; FCERI mediated MAPK activation; Signaling by ALK fusions and activated point mutants; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Activation of the AP-1 family of transcription factors" "66" "0" "1.036" "1.060" "0.904" "0.954" "0.986" "0.985" "0.926" "1.057" "0.958" "383.0" "396.8" "405.9" "346.2" "365.5" "377.5" "377.4" "354.6" "404.7" "366.9" "" "" "" "" "" "" "" "" "" "" "344.4" "321.0" "367.2" "337.9" "301.6" "377.5" "282.6" "313.2" "362.1" "131.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3251475669442544967" "False" "High" "IsMasterProtein" "Q9P270" "SLAIN motif-containing protein 2 OS=Homo sapiens OX=9606 GN=SLAIN2 PE=1 SV=2" "0.000" "False" "25.325" "13" "5" "6" "5" "581" "62.5" "9.45" "32.92" "5" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf15301" "57606" "ENSG00000109171" "SLAIN2" "A8K4P1; hsa:57606; Q8N5R3; Q9P270" "" "" "0" "0" "0.995" "1.060" "1.005" "1.021" "1.063" "1.202" "1.009" "0.891" "1.327" "607.4" "604.7" "643.7" "610.4" "620.4" "645.7" "729.9" "613.2" "541.1" "805.8" "" "" "" "" "" "" "" "" "" "" "546.1" "489.3" "582.2" "595.8" "512.0" "645.7" "546.5" "541.6" "484.2" "287.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-973328225883047536" "False" "High" "IsMasterProtein" "Q8IV48" "3'-5' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=ERI1 PE=1 SV=3" "0.000" "False" "25.325" "18" "7" "10" "7" "349" "40.0" "6.70" "31.95" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00929, Pf02037" "90459" "ENSG00000104626" "ERI1" "A8K4U7; hsa:90459; Q8IV48; Q9NSX3" "exRNA mechanism of action and biogenesis; 8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "Major pathway of rRNA processing in the nucleolus and cytosol" "4" "0" "0.916" "0.906" "0.852" "0.828" "1.019" "0.882" "0.775" "0.894" "1.446" "1200.2" "1099.1" "1087.7" "1022.2" "994.1" "1222.9" "1059.1" "930.0" "1073.5" "1735.9" "" "" "" "" "" "" "" "" "" "" "1079.1" "889.4" "983.9" "997.8" "820.4" "1222.9" "793.0" "821.4" "960.6" "619.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3857525489381916364" "False" "High" "IsMasterProtein" "A8MXV4" "Acyl-coenzyme A diphosphatase NUDT19 OS=Homo sapiens OX=9606 GN=NUDT19 PE=1 SV=1" "0.000" "False" "25.310" "19" "6" "8" "6" "375" "42.2" "7.64" "32.42" "6" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "" "390916" "ENSG00000213965" "NUDT19" "A8MXV4; hsa:390916" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "0.975" "0.899" "1.183" "1.006" "1.075" "1.014" "1.033" "1.096" "0.741" "520.3" "507.4" "467.6" "615.8" "523.7" "559.2" "527.7" "537.8" "570.4" "385.5" "" "" "" "" "" "" "" "" "" "" "467.8" "410.6" "423.0" "601.1" "432.1" "559.2" "395.2" "475.0" "510.4" "137.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7480523710602738279" "False" "High" "IsMasterProtein" "Q9BPZ3" "Polyadenylate-binding protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=PAIP2 PE=1 SV=1" "0.000" "False" "25.299" "38" "4" "10" "4" "127" "15.0" "4.12" "41.72" "4" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf07145" "51247" "ENSG00000120727" "PAIP2" "B2RBI1; D3DQC6; hsa:51247; Q49A06; Q9BPZ3; Q9H0Y5; Q9P0Q8" "" "" "0" "0" "0.946" "0.963" "0.883" "0.973" "1.016" "0.955" "0.958" "0.918" "0.783" "965.0" "912.8" "928.9" "851.7" "938.7" "980.9" "921.7" "924.8" "885.9" "755.9" "" "" "" "" "" "" "" "" "" "" "867.7" "738.6" "840.2" "831.4" "774.6" "980.9" "690.2" "816.8" "792.7" "269.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4573185288358324905" "False" "High" "IsMasterProtein" "P21953" "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Homo sapiens OX=9606 GN=BCKDHB PE=1 SV=2" "0.000" "False" "25.280" "16" "6" "8" "6" "392" "43.1" "6.29" "31.30" "6" "other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02779, Pf02780" "594" "ENSG00000083123" "BCKDHB" "hsa:594; P21953; Q5T2J3; Q9BQL0" "Primary ovarian insufficiency" "Glyoxylate metabolism and glycine degradation; Branched-chain amino acid catabolism" "3" "0" "1.079" "0.986" "0.930" "1.055" "0.979" "1.041" "0.995" "1.046" "0.815" "985.6" "1063.2" "971.6" "916.2" "1040.2" "964.4" "1025.6" "980.9" "1030.9" "803.4" "" "" "" "" "" "" "" "" "" "" "886.2" "860.3" "878.8" "894.3" "858.4" "964.4" "767.9" "866.4" "922.4" "286.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5219092479354345629" "False" "High" "IsMasterProtein" "O94855" "Protein transport protein Sec24D OS=Homo sapiens OX=9606 GN=SEC24D PE=1 SV=2" "0.000" "False" "25.278" "10" "8" "9" "7" "1032" "112.9" "7.25" "30.97" "8" "cell organization and biogenesis;transport;developmental processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "9871" "ENSG00000150961" "SEC24D" "hsa:9871; O94855; Q8IYI7" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "1.058" "1.122" "1.149" "1.127" "0.993" "1.040" "1.107" "1.121" "0.926" "325.5" "344.4" "365.2" "374.1" "366.8" "323.2" "338.6" "360.2" "364.8" "301.3" "" "" "" "" "" "" "" "" "" "" "292.6" "278.7" "330.3" "365.1" "302.7" "323.2" "253.6" "318.2" "326.4" "107.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660276496901993886" "False" "High" "IsMasterProtein" "Q96SY0" "Integrator complex subunit 14 OS=Homo sapiens OX=9606 GN=INTS14 PE=1 SV=2" "0.000" "False" "25.261" "14" "7" "8" "7" "518" "57.4" "5.12" "26.30" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf13519, Pf19435, Pf20504" "81556" "ENSG00000138614" "INTS14" "B4DDI6; B4DVD5; hsa:81556; Q49AH8; Q96HX5; Q96SY0; Q9H0S5" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.907" "0.917" "0.937" "0.993" "1.014" "0.925" "0.911" "0.959" "0.907" "474.7" "430.6" "435.5" "444.8" "471.5" "481.2" "439.0" "432.5" "455.1" "430.4" "" "" "" "" "" "" "" "" "" "" "426.8" "348.5" "393.9" "434.2" "389.1" "481.2" "328.7" "382.0" "407.3" "153.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-486365272632798294" "False" "High" "IsMasterProtein" "Q8WUW1" "Protein BRICK1 OS=Homo sapiens OX=9606 GN=BRK1 PE=1 SV=1" "0.000" "False" "25.257" "53" "4" "12" "4" "75" "8.7" "5.45" "35.81" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "55845" "ENSG00000254999" "BRK1" "B2R5E2; hsa:55845; Q8WUW1; Q9P082" "Regulation of actin cytoskeleton" "VEGFA-VEGFR2 Pathway; Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RAC1 GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RAC2 GTPase cycle; RAC3 GTPase cycle" "8" "0" "0.993" "1.018" "1.023" "0.999" "1.009" "0.983" "1.049" "1.025" "0.832" "892.1" "886.1" "908.2" "912.8" "891.0" "899.7" "877.3" "936.1" "914.2" "742.4" "" "" "" "" "" "" "" "" "" "" "802.1" "717.0" "821.5" "891.0" "735.3" "899.7" "656.9" "826.8" "818.0" "265.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8312562393160644927" "False" "High" "IsMasterProtein" "Q8WV22" "Non-structural maintenance of chromosomes element 1 homolog OS=Homo sapiens OX=9606 GN=NSMCE1 PE=1 SV=5" "0.000" "False" "25.254" "22" "6" "7" "6" "266" "30.8" "7.47" "28.39" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07574, Pf08746" "197370" "ENSG00000169189" "NSMCE1" "D3DWF6; hsa:197370; Q8WV22; Q9P045; Q9P049" "" "SUMOylation of DNA damage response and repair proteins" "1" "0" "0.968" "1.084" "1.015" "1.109" "1.039" "1.008" "1.056" "1.029" "1.076" "368.3" "356.4" "399.2" "373.9" "408.4" "382.5" "371.4" "388.8" "379.1" "396.3" "" "" "" "" "" "" "" "" "" "" "331.2" "288.4" "361.1" "365.0" "337.0" "382.5" "278.1" "343.4" "339.2" "141.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5096502141000675032" "False" "High" "IsMasterProtein" "Q8TBB5" "Kelch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KLHDC4 PE=1 SV=1" "0.000" "False" "25.250" "18" "7" "8" "7" "520" "57.9" "5.72" "32.10" "7" "" "" "" "Pf13415, Pf13418" "54758" "ENSG00000104731" "KLHDC4" "D3DUN3; D3DUN4; D3DUN5; hsa:54758; Q8TBB5; Q96F29; Q9BVN3" "" "" "0" "0" "1.051" "1.096" "1.154" "1.141" "1.065" "1.009" "1.064" "1.124" "1.072" "493.4" "518.8" "540.7" "569.4" "563.2" "525.7" "497.7" "525.0" "554.4" "528.9" "" "" "" "" "" "" "" "" "" "" "443.6" "419.8" "489.1" "555.8" "464.8" "525.7" "372.7" "463.7" "496.1" "188.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2572043715436263453" "False" "High" "IsMasterProtein" "Q9H3R5" "Centromere protein H OS=Homo sapiens OX=9606 GN=CENPH PE=1 SV=1" "0.000" "False" "25.238" "22" "5" "8" "5" "247" "28.5" "5.29" "29.74" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "other molecular function" "Pf05837" "64946" "ENSG00000153044" "CENPH" "A8K3Y1; hsa:64946; Q9H3R5" "" "Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "0.990" "1.187" "0.937" "1.016" "1.039" "1.110" "0.947" "1.048" "2.233" "331.3" "328.1" "393.1" "310.3" "336.7" "344.2" "367.8" "313.6" "347.1" "739.7" "" "" "" "" "" "" "" "" "" "" "297.8" "265.5" "355.6" "302.9" "277.8" "344.2" "275.4" "276.9" "310.6" "264.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3102131592095934236" "False" "High" "IsMasterProtein" "Q969G6" "Riboflavin kinase OS=Homo sapiens OX=9606 GN=RFK PE=1 SV=2" "0.000" "False" "25.237" "36" "6" "11" "6" "155" "17.6" "8.13" "36.16" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "kinase activity;other molecular function" "Pf01687" "55312" "ENSG00000135002" "RFK" "hsa:55312; Q5JSG9; Q969G6; Q9NUT7" "Selenium micronutrient network; Folate metabolism; TNF-alpha signaling pathway" "Vitamin B2 (riboflavin) metabolism" "4" "0" "1.004" "1.013" "0.980" "1.097" "0.956" "1.030" "0.987" "1.068" "0.935" "1214.6" "1219.1" "1230.9" "1189.8" "1332.5" "1160.6" "1251.5" "1199.1" "1297.6" "1135.9" "" "" "" "" "" "" "" "" "" "" "1092.1" "986.5" "1113.4" "1161.4" "1099.6" "1160.6" "937.1" "1059.1" "1161.1" "405.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218333417811039911" "False" "High" "IsMasterProtein" "Q9H299" "SH3 domain-binding glutamic acid-rich-like protein 3 OS=Homo sapiens OX=9606 GN=SH3BGRL3 PE=1 SV=1" "0.000" "False" "25.225" "39" "4" "18" "4" "93" "10.4" "4.93" "70.81" "4" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf04908" "83442" "ENSG00000142669" "SH3BGRL3" "hsa:83442; Q5T122; Q9H299" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.020" "1.019" "0.991" "0.989" "1.021" "1.004" "1.042" "0.992" "0.923" "1499.1" "1529.7" "1528.4" "1485.3" "1483.1" "1530.4" "1504.6" "1562.6" "1486.9" "1383.9" "" "" "" "" "" "" "" "" "" "" "1347.9" "1237.7" "1382.5" "1449.8" "1223.9" "1530.4" "1126.6" "1380.2" "1330.5" "494.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-932703795777546839" "False" "High" "IsMasterProtein" "Q96BJ3" "Axin interactor, dorsalization-associated protein OS=Homo sapiens OX=9606 GN=AIDA PE=1 SV=1" "0.000" "False" "25.222" "24" "6" "8" "6" "306" "35.0" "6.55" "27.24" "6" "developmental processes;other biological processes" "other membranes;other cell component" "other molecular function" "Pf08910, Pf14186" "64853" "ENSG00000186063" "AIDA" "A8K1F0; hsa:64853; Q49A81; Q5JRA4; Q658P1; Q96BJ3; Q9H9E8" "" "" "0" "0" "0.968" "0.981" "0.932" "1.120" "0.945" "0.987" "1.023" "1.039" "0.932" "369.0" "357.1" "362.0" "343.9" "413.3" "348.8" "364.0" "377.6" "383.5" "344.0" "" "" "" "" "" "" "" "" "" "" "331.8" "288.9" "327.5" "335.7" "341.1" "348.8" "272.6" "333.6" "343.1" "122.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8730523960052608716" "False" "High" "IsMasterProtein" "O60879" "Protein diaphanous homolog 2 OS=Homo sapiens OX=9606 GN=DIAPH2 PE=1 SV=1" "0.000" "False" "25.190" "7" "8" "8" "8" "1101" "125.5" "6.58" "23.44" "8" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "1730" "ENSG00000147202" "DIAPH2" "A6NG19; hsa:1730; O60878; O60879; Q8WX06; Q8WX48; Q9UJL2" "Primary ovarian insufficiency" "RHOF GTPase cycle" "2" "0" "0.990" "0.983" "1.054" "1.001" "0.962" "1.038" "0.906" "0.916" "3.731" "599.7" "593.9" "589.7" "632.1" "600.3" "577.1" "622.4" "543.5" "549.6" "2237.3" "" "" "" "" "" "" "" "" "" "" "539.2" "480.5" "533.4" "617.0" "495.4" "577.1" "466.0" "480.1" "491.7" "798.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3137341147702067960" "False" "High" "IsMasterProtein" "P26440" "Isovaleryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=IVD PE=1 SV=2" "0.000" "False" "25.187" "22" "8" "9" "8" "426" "46.6" "8.05" "27.12" "8" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00441, Pf02770, Pf02771" "3712" "ENSG00000128928" "IVD" "B2RCV5; B3KVI7; hsa:3712; J3KR54; P26440; Q53XZ9; Q96AF6" "Valproic acid pathway" "Branched-chain amino acid catabolism" "2" "0" "1.022" "0.997" "1.006" "1.066" "0.941" "1.050" "1.017" "1.018" "0.812" "811.7" "829.3" "809.4" "816.7" "865.3" "764.2" "852.1" "825.4" "826.5" "659.3" "" "" "" "" "" "" "" "" "" "" "729.8" "671.0" "732.2" "797.2" "714.1" "764.2" "638.0" "729.0" "739.5" "235.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2974219725755957834" "False" "High" "IsMasterProtein" "Q5HYJ3" "Protein FAM76B OS=Homo sapiens OX=9606 GN=FAM76B PE=1 SV=3" "0.000" "False" "25.140" "24" "9" "12" "8" "339" "38.7" "9.25" "37.43" "9" "" "nucleus" "" "Pf16046" "143684" "ENSG00000077458" "FAM76B" "B2R9C2; hsa:143684; Q5HYJ3; Q6PIU3; Q8TC53" "" "" "0" "1" "0.853" "0.978" "0.859" "0.934" "1.172" "0.852" "0.917" "1.023" "0.791" "812.3" "693.1" "794.3" "697.8" "758.8" "951.8" "692.1" "745.1" "831.3" "642.5" "" "" "" "" "" "" "" "" "" "" "730.4" "560.8" "718.4" "681.2" "626.2" "951.8" "518.2" "658.1" "743.8" "229.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548984541792378367" "False" "High" "IsMasterProtein" "Q9Y5Y2" "Cytosolic Fe-S cluster assembly factor NUBP2 OS=Homo sapiens OX=9606 GN=NUBP2 PE=1 SV=1" "0.000" "False" "25.139" "27" "5" "8" "5" "271" "28.8" "5.83" "32.10" "5" "cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10609" "10101" "ENSG00000095906" "NUBP2" "D3DU80; hsa:10101; Q9NWB2; Q9Y5Y2" "Iron-sulfur cluster biogenesis" "Cytosolic iron-sulfur cluster assembly" "2" "0" "1.188" "1.118" "1.186" "1.213" "1.167" "1.228" "1.240" "1.229" "0.990" "310.2" "368.6" "346.8" "367.8" "376.3" "361.8" "380.8" "384.5" "381.2" "306.9" "" "" "" "" "" "" "" "" "" "" "278.9" "298.3" "313.6" "359.1" "310.5" "361.8" "285.1" "339.6" "341.1" "109.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794546056511531982" "False" "High" "IsMasterProtein" "Q969Q5" "Ras-related protein Rab-24 OS=Homo sapiens OX=9606 GN=RAB24 PE=1 SV=1" "0.000" "False" "25.134" "37" "7" "8" "7" "203" "23.1" "6.23" "30.90" "7" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "53917" "ENSG00000169228" "RAB24" "A0A024R7N9; hsa:53917; Q7Z4Z7; Q969Q5" "5q35 copy number variation" "Neutrophil degranulation; RAB geranylgeranylation" "3" "0" "1.069" "1.128" "0.961" "1.003" "1.018" "1.077" "1.024" "1.049" "0.932" "453.7" "485.2" "511.6" "436.1" "455.3" "461.9" "488.9" "464.8" "476.1" "422.7" "" "" "" "" "" "" "" "" "" "" "407.9" "392.6" "462.8" "425.7" "375.7" "461.9" "366.0" "410.5" "426.1" "150.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266332044031462775" "False" "High" "IsMasterProtein" "O43324" "Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens OX=9606 GN=EEF1E1 PE=1 SV=1" "0.000" "False" "25.108" "28" "5" "9" "5" "174" "19.8" "8.54" "30.30" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00043" "9521" "ENSG00000124802" "EEF1E1" "C9JLK5; hsa:9521; O43324; Q5THS2" "" "Selenoamino acid metabolism; Cytosolic tRNA aminoacylation" "2" "0" "0.953" "1.029" "0.984" "0.923" "0.961" "1.001" "0.954" "1.024" "3.080" "1184.2" "1128.1" "1218.1" "1165.4" "1092.9" "1137.9" "1185.5" "1130.2" "1212.2" "3647.5" "" "" "" "" "" "" "" "" "" "" "1064.7" "912.8" "1101.8" "1137.6" "901.9" "1137.9" "887.7" "998.3" "1084.6" "1302.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985839782283071822" "False" "High" "IsMasterProtein" "P10619" "Lysosomal protective protein OS=Homo sapiens OX=9606 GN=CTSA PE=1 SV=2" "0.000" "False" "25.100" "11" "5" "8" "5" "480" "54.4" "6.61" "32.57" "5" "protein metabolism;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00450" "5476" "ENSG00000064601" "CTSA" "B2R798; hsa:5476; P10619; Q561W6; Q5JZH1; Q96KJ2; Q9BR08; Q9BW68" "Ciliary landscape" "Neutrophil degranulation; MHC class II antigen presentation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "6" "0" "0.947" "1.009" "0.943" "1.015" "0.991" "0.926" "0.946" "1.035" "0.807" "908.0" "859.6" "916.6" "856.0" "922.0" "900.0" "841.0" "859.2" "939.9" "732.4" "" "" "" "" "" "" "" "" "" "" "816.4" "695.5" "829.1" "835.6" "760.8" "900.0" "629.7" "758.9" "841.0" "261.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311926917854502333" "False" "High" "IsMasterProtein" "O43414" "ERI1 exoribonuclease 3 OS=Homo sapiens OX=9606 GN=ERI3 PE=1 SV=2" "0.000" "False" "25.084" "19" "6" "11" "6" "337" "37.2" "8.07" "35.97" "6" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf00929" "79033" "ENSG00000117419" "ERI3" "B1AK98; hsa:79033; O43414; Q5T2T7; Q5T2T9; Q5TG35; Q9BQA0; Q9UEB4" "" "" "0" "0" "1.060" "1.052" "0.979" "1.148" "0.931" "1.069" "1.059" "1.002" "0.852" "1106.0" "1172.5" "1163.1" "1082.3" "1270.1" "1029.5" "1182.5" "1171.6" "1108.2" "942.3" "" "" "" "" "" "" "" "" "" "" "994.4" "948.8" "1052.0" "1056.4" "1048.1" "1029.5" "885.4" "1034.8" "991.6" "336.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5044889676122240904" "False" "High" "IsMasterProtein" "Q9H270" "Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens OX=9606 GN=VPS11 PE=1 SV=1" "0.000" "False" "25.075" "9" "7" "8" "7" "941" "107.8" "7.05" "31.44" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00637, Pf12451, Pf13923" "55823" "" "VPS11" "hsa:55823; Q8WY89; Q96EP8; Q9H270; Q9H6D9; Q9HCS6" "Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "2" "0" "0.947" "0.945" "0.938" "0.993" "0.934" "0.998" "0.927" "1.030" "1.415" "553.3" "524.0" "522.7" "519.1" "549.2" "516.7" "552.1" "512.8" "569.8" "782.7" "" "" "" "" "" "" "" "" "" "" "497.5" "424.0" "472.8" "506.7" "453.2" "516.7" "413.4" "452.9" "509.8" "279.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5304133680658965036" "False" "High" "IsMasterProtein" "Q16629" "Serine/arginine-rich splicing factor 7 OS=Homo sapiens OX=9606 GN=SRSF7 PE=1 SV=1" "0.000" "False" "25.072" "25" "6" "12" "5" "238" "27.4" "11.82" "38.28" "6" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6432" "ENSG00000115875" "SRSF7" "B4DLU6; G5E9M3; hsa:6432; Q16629; Q564D3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "1" "0.993" "0.910" "0.947" "1.063" "0.929" "1.059" "1.012" "0.921" "1.103" "438.4" "435.5" "398.9" "415.2" "466.0" "407.4" "464.4" "443.8" "403.6" "483.7" "" "" "" "" "" "" "" "" "" "" "394.2" "352.4" "360.9" "405.3" "384.5" "407.4" "347.8" "391.9" "361.2" "172.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7106533515535511067" "False" "High" "IsMasterProtein" "Q969E8" "Pre-rRNA-processing protein TSR2 homolog OS=Homo sapiens OX=9606 GN=TSR2 PE=1 SV=1" "0.000" "False" "25.047" "21" "4" "9" "4" "191" "20.9" "4.39" "28.82" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10273" "90121" "ENSG00000158526" "TSR2" "hsa:90121; Q969E8" "" "" "0" "0" "0.972" "0.994" "0.919" "1.015" "1.080" "1.010" "1.025" "1.020" "0.824" "1206.0" "1172.9" "1198.8" "1108.0" "1223.6" "1301.9" "1218.3" "1235.9" "1229.8" "993.8" "" "" "" "" "" "" "" "" "" "" "1084.4" "949.0" "1084.4" "1081.5" "1009.8" "1301.9" "912.2" "1091.7" "1100.5" "354.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9198167910452048535" "False" "High" "IsMasterProtein" "P18887" "DNA repair protein XRCC1 OS=Homo sapiens OX=9606 GN=XRCC1 PE=1 SV=3" "0.000" "False" "25.043" "13" "8" "8" "8" "633" "69.5" "6.28" "28.02" "8" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01834" "7515" "ENSG00000073050" "XRCC1" "hsa:7515; P18887; Q6IBS4; Q9HCB1" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "8" "0" "0.992" "0.996" "1.017" "0.955" "1.019" "1.061" "0.985" "0.912" "1.511" "521.8" "517.9" "519.6" "530.7" "498.2" "531.9" "553.5" "513.9" "476.1" "788.3" "" "" "" "" "" "" "" "" "" "" "469.2" "419.1" "470.0" "518.0" "411.2" "531.9" "414.5" "453.9" "426.0" "281.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3647581331953333811" "False" "High" "IsMasterProtein" "Q658Y4" "Protein FAM91A1 OS=Homo sapiens OX=9606 GN=FAM91A1 PE=1 SV=3" "0.000" "False" "25.015" "11" "9" "12" "9" "838" "93.9" "6.39" "25.22" "9" "cell organization and biogenesis;transport" "ER/Golgi;other cell component" "" "Pf14647, Pf14648" "157769" "ENSG00000176853" "FAM91A1" "B6YY23; hsa:157769; Q658T5; Q658Y4; Q8TE89" "Gastric cancer network 2" "RHOH GTPase cycle" "2" "0" "1.021" "1.005" "1.015" "1.046" "0.990" "1.062" "1.116" "1.024" "0.911" "379.0" "387.1" "380.9" "384.7" "396.2" "375.1" "402.5" "422.9" "388.1" "345.1" "" "" "" "" "" "" "" "" "" "" "340.7" "313.2" "344.5" "375.5" "327.0" "375.1" "301.4" "373.5" "347.3" "123.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7544877575899964257" "False" "High" "IsMasterProtein" "Q96C57" "Protein CUSTOS OS=Homo sapiens OX=9606 GN=CUSTOS PE=1 SV=2" "0.000" "False" "24.993" "28" "5" "6" "5" "262" "28.2" "9.42" "27.87" "5" "cell-cell signaling;signal transduction;other biological processes" "nucleus" "" "" "64897" "ENSG00000157895" "CUSTOS" "Q53HF0; Q96C57; Q9H9Z7" "" "" "0" "0" "1.061" "1.042" "1.023" "1.124" "1.228" "0.999" "1.175" "0.986" "0.670" "292.1" "310.0" "304.3" "298.9" "328.1" "358.6" "291.8" "343.1" "288.0" "195.8" "" "" "" "" "" "" "" "" "" "" "262.6" "250.8" "275.3" "291.8" "270.8" "358.6" "218.5" "303.1" "257.7" "69.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530888468156294697" "False" "High" "IsMasterProtein" "O00541" "Pescadillo homolog OS=Homo sapiens OX=9606 GN=PES1 PE=1 SV=1" "0.000" "False" "24.983" "14" "7" "7" "7" "588" "68.0" "7.33" "26.18" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06732, Pf16589" "23481" "ENSG00000100029" "PES1" "hsa:23481; O00541; Q6IC29" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.047" "1.050" "1.044" "1.065" "0.964" "1.141" "0.992" "1.016" "4.141" "564.2" "590.7" "592.3" "589.0" "601.2" "544.1" "643.9" "560.0" "573.1" "2336.4" "" "" "" "" "" "" "" "" "" "" "507.3" "478.0" "535.8" "574.9" "496.1" "544.1" "482.2" "494.6" "512.8" "834.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4539117867176903484" "False" "High" "IsMasterProtein" "P50402" "Emerin OS=Homo sapiens OX=9606 GN=EMD PE=1 SV=1" "0.000" "False" "24.974" "27" "6" "9" "6" "254" "29.0" "5.50" "32.81" "6" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity" "Pf03020" "2010" "ENSG00000102119" "EMD" "hsa:2010; P50402; Q6FI02" "Arrhythmogenic right ventricular cardiomyopathy; Envelope proteins and their potential roles in EDMD physiopathology; Influence of laminopathies on Wnt signaling" "RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "12" "0" "0.880" "0.975" "1.088" "0.992" "0.933" "1.011" "0.987" "0.926" "0.825" "654.2" "575.7" "637.8" "711.4" "648.8" "610.2" "661.5" "645.6" "605.7" "539.7" "" "" "" "" "" "" "" "" "" "" "588.2" "465.9" "576.9" "694.4" "535.4" "610.2" "495.3" "570.2" "542.0" "192.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3431130476793294573" "False" "High" "IsMasterProtein" "Q8IUR0" "Trafficking protein particle complex subunit 5 OS=Homo sapiens OX=9606 GN=TRAPPC5 PE=1 SV=1" "0.000" "False" "24.970" "34" "7" "8" "7" "188" "20.8" "9.66" "23.31" "7" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04051" "126003" "ENSG00000181029" "TRAPPC5" "A8K7I6; hsa:126003; Q8IUR0" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.127" "1.031" "0.976" "1.138" "1.013" "1.140" "1.033" "0.967" "1.125" "628.1" "707.6" "647.7" "613.2" "715.0" "636.3" "715.8" "649.0" "607.1" "706.6" "" "" "" "" "" "" "" "" "" "" "564.7" "572.5" "585.9" "598.5" "590.0" "636.3" "536.0" "573.3" "543.3" "252.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7958389170144649522" "False" "High" "IsMasterProtein" "P45983" "Mitogen-activated protein kinase 8 OS=Homo sapiens OX=9606 GN=MAPK8 PE=1 SV=2" "0.000" "False" "24.960" "14" "6" "9" "1" "427" "48.3" "6.89" "31.21" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "5599" "ENSG00000107643" "MAPK8" "B5BTZ5; B7ZLV4; D3DX88; D3DX92; hsa:5599; P45983; Q15709; Q15712; Q15713; Q308M2" "Osteoclast signaling; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered regulated necrosis; Ebstein-Barr virus LMP1 signaling; Cardiac hypertrophic response; IL-3 signaling pathway; Nod-like receptor (NLR) signaling pathway; Transcriptional activation by NRF2 in response to phytochemicals; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Hypothesized pathways in pathogenesis of cardiovascular disease; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; Canonical and non-canonical TGF-B signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; PDGFR-beta pathway; Wnt signaling in kidney disease; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Pancreatic adenocarcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; Wnt signaling; miRNA role in immune response in sepsis; Neovascularization processes; Non-genomic actions of 1,25 dihydroxyvitamin D3; NRF2-ARE regulation; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Signal transduction through IL1R; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Regulatory circuits of the STAT3 signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; Pleural mesothelioma; CCL18 signaling pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Roles of ceramides in development of insulin resistance; IL-26 signaling pathways; 10q11.21q11.23 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; 13q12.12 copy number variation; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Signaling by ALK fusions and activated point mutants; FCERI mediated MAPK activation; NRAGE signals death through JNK; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; WNT5:FZD7-mediated leishmania damping; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; DSCAM interactions; Activation of BIM and translocation to mitochondria ; Activation of the AP-1 family of transcription factors; NRIF signals cell death from the nucleus; Activation of BMF and translocation to mitochondria; Interleukin-38 signaling" "99" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3161881869701219173" "False" "High" "IsMasterProtein" "O43715" "TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens OX=9606 GN=TRIAP1 PE=1 SV=1" "0.000" "False" "24.939" "57" "5" "9" "5" "76" "8.8" "5.48" "36.77" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf05254" "51499" "ENSG00000170855" "TRIAP1" "B2R4Z7; hsa:51499; O43715; Q5RKS5; Q6LCA7" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "1.051" "0.978" "0.997" "0.983" "1.075" "1.002" "1.010" "0.972" "0.832" "1279.0" "1344.8" "1250.5" "1274.8" "1257.9" "1375.3" "1281.6" "1292.5" "1243.8" "1063.9" "" "" "" "" "" "" "" "" "" "" "1150.0" "1088.2" "1131.1" "1244.4" "1038.0" "1375.3" "959.6" "1141.6" "1112.9" "379.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3575198767162097907" "False" "High" "IsMasterProtein" "Q9BXV9" "EKC/KEOPS complex subunit GON7 OS=Homo sapiens OX=9606 GN=GON7 PE=1 SV=2" "0.000" "False" "24.936" "76" "4" "8" "4" "100" "10.9" "4.27" "39.87" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15387" "84520" "ENSG00000170270; ENSG00000275619" "GON7" "Q0D2N1; Q0P6C4; Q3B7W5; Q9BXV9" "" "" "0" "0" "0.900" "1.037" "0.874" "0.990" "0.975" "0.909" "0.984" "0.944" "0.780" "371.0" "334.0" "384.6" "324.1" "367.1" "361.9" "337.1" "365.0" "350.3" "289.3" "" "" "" "" "" "" "" "" "" "" "333.6" "270.3" "347.9" "316.4" "303.0" "361.9" "252.4" "322.4" "313.4" "103.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5878749091954707236" "False" "High" "IsMasterProtein" "Q9NXA8" "NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT5 PE=1 SV=2" "0.000" "False" "24.917" "21" "5" "8" "5" "310" "33.9" "8.47" "28.37" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf02146" "23408" "ENSG00000124523" "SIRT5" "B4DFM4; B4DYJ5; F5H5Z9; hsa:23408; Q5T294; Q5T295; Q9NXA8; Q9Y6E6" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "Transcriptional activation of mitochondrial biogenesis" "4" "0" "1.042" "0.901" "1.022" "1.077" "0.977" "0.992" "1.072" "1.006" "0.975" "423.1" "441.1" "381.1" "432.5" "455.7" "413.2" "419.6" "453.4" "425.6" "412.6" "" "" "" "" "" "" "" "" "" "" "380.4" "356.9" "344.7" "422.2" "376.1" "413.2" "314.2" "400.5" "380.8" "147.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1890779364620067180" "False" "High" "IsMasterProtein" "Q96CD2" "Phosphopantothenoylcysteine decarboxylase OS=Homo sapiens OX=9606 GN=PPCDC PE=1 SV=2" "0.000" "False" "24.915" "37" "6" "8" "6" "204" "22.4" "6.10" "31.23" "6" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf02441" "60490" "ENSG00000138621" "PPCDC" "hsa:60490; Q96CD2; Q96SX0; Q9HC17" "" "Coenzyme A biosynthesis" "1" "0" "1.115" "1.134" "1.169" "1.300" "1.290" "1.194" "1.179" "1.254" "0.995" "350.1" "390.3" "396.9" "409.1" "455.2" "451.5" "418.1" "412.9" "438.9" "348.4" "" "" "" "" "" "" "" "" "" "" "314.7" "315.8" "359.0" "399.4" "375.7" "451.5" "313.0" "364.7" "392.7" "124.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3213067895580761470" "False" "High" "IsMasterProtein" "Q96CU9" "FAD-dependent oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FOXRED1 PE=1 SV=2" "0.000" "False" "24.881" "16" "6" "7" "6" "486" "53.8" "7.78" "26.25" "6" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01266" "55572" "ENSG00000110074" "FOXRED1" "B3KN84; B4DHU2; hsa:55572; Q71MG0; Q96CU9; Q9BU39; Q9UKY9" "" "" "0" "0" "0.975" "1.031" "0.943" "1.023" "1.081" "0.995" "0.960" "1.011" "0.972" "884.3" "862.5" "911.5" "833.5" "905.0" "956.1" "880.2" "849.1" "894.2" "859.7" "" "" "" "" "" "" "" "" "" "" "795.0" "697.9" "824.5" "813.6" "746.8" "956.1" "659.1" "750.0" "800.1" "306.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8214160649428381093" "False" "High" "IsMasterProtein" "P22415" "Upstream stimulatory factor 1 OS=Homo sapiens OX=9606 GN=USF1 PE=1 SV=1" "0.000" "False" "24.876" "20" "6" "9" "3" "310" "33.5" "5.54" "30.88" "6" "stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7391" "ENSG00000158773" "USF1" "B2RBZ4; hsa:7391; P22415; Q5SY46; Q7Z5Y1" "7q11.23 copy number variation syndrome; Familial hyperlipidemia type 2" "Estrogen-dependent gene expression" "3" "0" "1.059" "1.024" "0.978" "1.061" "1.057" "1.004" "1.032" "1.054" "1.081" "279.9" "296.4" "286.6" "273.8" "297.1" "296.0" "281.2" "288.8" "295.1" "302.7" "" "" "" "" "" "" "" "" "" "" "251.7" "239.9" "259.2" "267.3" "245.2" "296.0" "210.5" "255.1" "264.0" "108.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1655251497259487415" "False" "High" "IsMasterProtein" "Q9BV38" "WD repeat-containing protein 18 OS=Homo sapiens OX=9606 GN=WDR18 PE=1 SV=2" "0.000" "False" "24.856" "18" "7" "7" "7" "432" "47.4" "6.70" "27.64" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf14077" "57418" "ENSG00000065268" "WDR18" "hsa:57418; O60390; Q9BV38; Q9BWR2" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.038" "1.091" "0.892" "1.003" "1.057" "0.910" "0.901" "1.016" "1.126" "611.9" "635.1" "667.8" "545.8" "613.7" "647.0" "556.5" "551.4" "621.8" "689.1" "" "" "" "" "" "" "" "" "" "" "550.1" "513.9" "604.0" "532.8" "506.4" "647.0" "416.7" "487.0" "556.4" "246.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "215729870143927910" "False" "High" "IsMasterProtein" "P52815" "Large ribosomal subunit protein bL12m OS=Homo sapiens OX=9606 GN=MRPL12 PE=1 SV=2" "0.000" "False" "24.836" "29" "5" "13" "5" "198" "21.3" "8.87" "38.38" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00542, Pf16320" "6182" "ENSG00000262814" "MRPL12" "hsa:6182; P52815; Q969U0; Q9HCA2; Q9UQJ3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.054" "0.999" "0.954" "0.975" "1.133" "1.019" "1.151" "0.960" "0.809" "890.4" "938.8" "889.5" "849.9" "868.0" "1009.1" "907.0" "1024.8" "855.0" "720.1" "" "" "" "" "" "" "" "" "" "" "800.6" "759.7" "804.6" "829.6" "716.3" "1009.1" "679.1" "905.2" "765.1" "257.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3096317975956610268" "False" "High" "IsMasterProtein" "Q9HBL8" "NmrA-like family domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NMRAL1 PE=1 SV=1" "0.000" "False" "24.835" "28" "9" "11" "9" "299" "33.3" "7.52" "37.25" "9" "" "cytosol;nucleus;other cell component" "other molecular function" "Pf05368" "57407" "ENSG00000153406; ENSG00000274684" "NMRAL1" "hsa:57407; Q9HBL8" "" "Urea cycle" "1" "0" "0.996" "1.018" "0.937" "1.033" "0.984" "0.989" "0.966" "1.008" "1.168" "1269.8" "1264.3" "1293.3" "1189.2" "1311.6" "1249.2" "1255.8" "1226.0" "1280.5" "1482.7" "" "" "" "" "" "" "" "" "" "" "1141.7" "1023.0" "1169.8" "1160.8" "1082.4" "1249.2" "940.3" "1082.9" "1145.8" "529.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5841636671217917151" "False" "High" "IsMasterProtein" "Q5JTJ3" "Cytochrome c oxidase assembly factor 6 homolog OS=Homo sapiens OX=9606 GN=COA6 PE=1 SV=1" "0.000" "False" "24.834" "32" "3" "8" "3" "125" "14.1" "8.25" "33.04" "3" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf02297" "388753" "ENSG00000168275" "COA6" "hsa:388753; Q5JTJ2; Q5JTJ3; Q5JTJ4; Q8TA88" "Mitochondrial complex IV assembly" "Mitochondrial protein import" "2" "0" "0.987" "0.970" "0.958" "1.089" "1.044" "0.966" "1.098" "1.009" "0.766" "888.3" "876.8" "861.8" "851.2" "967.2" "927.5" "858.3" "975.1" "896.1" "680.8" "" "" "" "" "" "" "" "" "" "" "798.6" "709.4" "779.5" "830.9" "798.2" "927.5" "642.7" "861.3" "801.8" "243.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3602671086497481481" "False" "High" "IsMasterProtein" "O43709" "18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens OX=9606 GN=BUD23 PE=1 SV=2" "0.000" "False" "24.826" "31" "7" "11" "7" "281" "31.9" "8.73" "48.04" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08241, Pf12589" "114049" "ENSG00000071462" "BUD23" "A8K501; C9K060; hsa:114049; O43709; Q96P12; Q9BQ58; Q9HBP9" "7q11.23 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "3" "0" "1.008" "1.081" "1.007" "1.108" "1.119" "0.997" "0.975" "1.103" "0.953" "670.5" "675.9" "724.5" "675.2" "742.6" "750.3" "668.2" "654.0" "739.8" "638.6" "" "" "" "" "" "" "" "" "" "" "602.8" "546.9" "655.4" "659.1" "612.8" "750.3" "500.4" "577.6" "661.9" "228.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "336772770148819757" "False" "High" "IsMasterProtein" "Q9NVR0" "Kelch-like protein 11 OS=Homo sapiens OX=9606 GN=KLHL11 PE=1 SV=1" "0.000" "False" "24.822" "8" "6" "7" "6" "708" "80.1" "6.16" "26.37" "6" "" "cytosol" "" "Pf00651, Pf01344, Pf07707" "55175" "ENSG00000178502" "KLHL11" "hsa:55175; Q9NVR0" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.084" "1.109" "0.989" "1.054" "1.098" "1.035" "0.969" "1.148" "1.007" "875.5" "949.4" "970.5" "866.2" "922.5" "961.8" "906.3" "848.8" "1004.9" "881.7" "" "" "" "" "" "" "" "" "" "" "787.2" "768.2" "877.9" "845.5" "761.3" "961.8" "678.6" "749.7" "899.2" "314.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8775799832689222428" "False" "High" "IsMasterProtein" "Q8IV38" "Ankyrin repeat and MYND domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKMY2 PE=1 SV=1" "0.000" "False" "24.785" "19" "6" "7" "6" "441" "49.3" "6.25" "26.49" "6" "" "other cell component" "other molecular function" "Pf01753, Pf12796" "57037" "ENSG00000106524" "ANKMY2" "A4D124; hsa:57037; Q659G1; Q8IV38; Q96BL3" "" "" "0" "0" "1.065" "1.153" "0.999" "1.072" "1.134" "1.087" "1.042" "1.141" "0.965" "816.4" "869.7" "941.3" "815.2" "875.3" "925.4" "887.0" "851.0" "931.6" "787.8" "" "" "" "" "" "" "" "" "" "" "734.0" "703.7" "851.5" "795.8" "722.3" "925.4" "664.2" "751.7" "833.6" "281.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564377166653415060" "False" "High" "IsMasterProtein" "Q5JS54" "Proteasome assembly chaperone 4 OS=Homo sapiens OX=9606 GN=PSMG4 PE=1 SV=2" "0.000" "False" "24.779" "37" "4" "7" "4" "123" "13.8" "6.52" "24.30" "4" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf16093" "389362" "ENSG00000180822" "PSMG4" "C9J2F8; F8WBZ2; hsa:389362; Q5JS53; Q5JS54; Q5JS56" "" "" "0" "0" "1.090" "0.920" "0.970" "0.958" "0.942" "1.018" "0.950" "1.061" "0.815" "305.8" "333.3" "281.1" "296.5" "292.9" "287.9" "311.2" "290.6" "324.4" "249.2" "" "" "" "" "" "" "" "" "" "" "274.9" "269.7" "254.3" "289.5" "241.7" "287.9" "233.1" "256.7" "290.3" "88.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7135249905505884321" "False" "High" "IsMasterProtein" "P0DTL6" "Zinc finger TRAF-type-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFTRAF1 PE=1 SV=1" "0.000" "False" "24.754" "16" "6" "10" "6" "404" "43.8" "6.76" "32.15" "6" "" "nucleus;other cell component" "other molecular function" "" "157542; 50626; 84773" "ENSG00000187954" "ZFTRAF1" "B3KSX0; D3DWM3; E9PJD7; hsa:157542; hsa:50626; hsa:84773; P0DTL6; Q6ZMK1; Q9BSF6; Q9BSU6" "" "" "0" "0" "1.000" "1.021" "0.991" "1.091" "1.013" "0.964" "0.982" "1.006" "0.993" "609.0" "608.8" "622.0" "603.8" "664.2" "616.8" "586.9" "598.2" "612.8" "604.8" "" "" "" "" "" "" "" "" "" "" "547.5" "492.6" "562.6" "589.3" "548.1" "616.8" "439.5" "528.4" "548.3" "215.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3715797868298302435" "False" "High" "IsMasterProtein" "Q5ST30" "Valine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=VARS2 PE=1 SV=2" "0.000" "False" "24.733" "8" "8" "8" "8" "1063" "118.4" "7.02" "28.56" "8" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00133, Pf08264" "57176" "ENSG00000137411; ENSG00000223494" "VARS2" "A2ABL7; B4DET4; B4E3P5; F5GXJ0; F5H323; hsa:57176; Q2M2A0; Q59FI1; Q5SQ96; Q5SS98; Q5ST30; Q6DKJ5; Q6ZV24; Q96GN2; Q96H77; Q96Q02; Q9H6R2; Q9UFH7" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.002" "0.975" "0.947" "0.997" "1.032" "1.028" "1.016" "0.991" "0.945" "539.1" "540.3" "525.9" "510.5" "537.7" "556.4" "554.3" "547.9" "534.4" "509.5" "" "" "" "" "" "" "" "" "" "" "484.7" "437.2" "475.7" "498.4" "443.7" "556.4" "415.1" "483.9" "478.2" "181.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "582663252060756755" "False" "High" "IsMasterProtein" "Q9NVX7" "Kelch repeat and BTB domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KBTBD4 PE=1 SV=4" "0.000" "False" "24.707" "9" "4" "6" "4" "534" "59.9" "5.77" "26.28" "4" "" "" "" "" "" "" "" "" "" "" "0" "0" "1.075" "1.101" "1.052" "1.099" "1.061" "1.069" "0.984" "1.126" "0.949" "446.3" "479.6" "491.3" "469.6" "490.4" "473.4" "477.0" "439.0" "502.6" "423.6" "" "" "" "" "" "" "" "" "" "" "401.2" "388.1" "444.4" "458.4" "404.7" "473.4" "357.1" "387.7" "449.7" "151.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8151909637929937359" "False" "High" "IsMasterProtein" "Q14554" "Protein disulfide-isomerase A5 OS=Homo sapiens OX=9606 GN=PDIA5 PE=1 SV=1" "0.000" "False" "24.699" "15" "7" "7" "7" "519" "59.6" "7.91" "22.79" "7" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00085" "10954" "ENSG00000065485" "PDIA5" "D3DN95; hsa:10954; Q14554; Q9BV43" "" "XBP1(S) activates chaperone genes" "1" "0" "0.981" "0.980" "0.941" "0.908" "0.938" "0.864" "0.923" "1.036" "0.885" "488.7" "479.6" "478.7" "459.8" "443.8" "458.2" "422.2" "451.0" "506.4" "432.7" "" "" "" "" "" "" "" "" "" "" "439.4" "388.1" "433.0" "448.8" "366.2" "458.2" "316.1" "398.4" "453.1" "154.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4795865386403905334" "False" "High" "IsMasterProtein" "Q9Y4Z0" "U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens OX=9606 GN=LSM4 PE=1 SV=1" "0.000" "False" "24.690" "32" "5" "16" "5" "139" "15.3" "9.99" "49.94" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "25804" "ENSG00000130520" "LSM4" "hsa:25804; Q9Y4Z0" "Ciliary landscape" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.928" "0.940" "0.960" "1.002" "0.920" "0.959" "0.996" "1.034" "0.774" "1414.1" "1312.4" "1328.6" "1357.7" "1417.0" "1300.6" "1356.5" "1408.4" "1462.3" "1093.9" "" "" "" "" "" "" "" "" "" "" "1271.4" "1061.9" "1201.8" "1325.3" "1169.3" "1300.6" "1015.7" "1244.0" "1308.4" "390.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3629092038123866655" "False" "High" "IsMasterProtein" "Q86TP1" "Exopolyphosphatase PRUNE1 OS=Homo sapiens OX=9606 GN=PRUNE1 PE=1 SV=2" "0.000" "False" "24.645" "15" "6" "8" "6" "453" "50.2" "5.50" "26.74" "6" "other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01368, Pf02833" "58497" "ENSG00000143363" "PRUNE1" "B2RCH8; B4DFL7; Q5SZF9; Q659E5; Q6P4E0; Q86TP1; Q8N654; Q96JU5; Q9C071; Q9C072; Q9UIV0" "" "" "0" "0" "0.999" "1.048" "1.002" "1.101" "1.034" "1.007" "1.058" "1.061" "1.087" "486.7" "486.1" "510.1" "487.4" "535.7" "503.4" "490.2" "514.7" "516.3" "529.1" "" "" "" "" "" "" "" "" "" "" "437.6" "393.3" "461.4" "475.8" "442.1" "503.4" "367.0" "454.6" "462.0" "188.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619472182958520531" "False" "High" "IsMasterProtein" "P61960" "Ubiquitin-fold modifier 1 OS=Homo sapiens OX=9606 GN=UFM1 PE=1 SV=1" "0.000" "False" "24.639" "59" "3" "11" "3" "85" "9.1" "9.31" "47.07" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "" "Pf03671" "51569" "ENSG00000120686" "UFM1" "hsa:51569; P61960; Q14346; Q5VXS0; Q6IAG6; Q9CPX2; Q9NZF2" "" "" "0" "0" "0.825" "0.903" "0.875" "0.927" "0.928" "0.903" "1.001" "0.874" "0.808" "1286.8" "1061.6" "1162.1" "1125.4" "1192.7" "1194.1" "1162.2" "1288.5" "1124.5" "1039.4" "" "" "" "" "" "" "" "" "" "" "1156.9" "859.0" "1051.2" "1098.6" "984.3" "1194.1" "870.3" "1138.1" "1006.2" "371.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2299067407351932215" "False" "High" "IsMasterProtein" "P28907" "ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 OS=Homo sapiens OX=9606 GN=CD38 PE=1 SV=2" "0.000" "False" "24.626" "29" "9" "12" "9" "300" "34.3" "7.66" "36.72" "9" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf02267" "952" "ENSG00000004468" "CD38" "hsa:952; O00121; O00122; P28907; Q96HY4" "NAD+ metabolism; NAD+ biosynthetic pathways; Cell-type dependent selectivity of CCK2R signaling; Airway smooth muscle cell contraction" "Nicotinate metabolism" "5" "0" "0.943" "0.908" "0.936" "0.904" "0.984" "0.978" "0.970" "1.017" "0.802" "730.8" "689.1" "663.3" "683.8" "660.3" "719.1" "714.3" "708.6" "743.3" "586.2" "" "" "" "" "" "" "" "" "" "" "657.0" "557.6" "600.0" "667.5" "544.9" "719.1" "534.9" "625.9" "665.1" "209.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2069331310574252297" "False" "High" "IsMasterProtein" "O43708" "Maleylacetoacetate isomerase OS=Homo sapiens OX=9606 GN=GSTZ1 PE=1 SV=3" "0.000" "False" "24.622" "32" "5" "10" "5" "216" "24.2" "8.54" "41.01" "5" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf13409, Pf14497" "2954" "ENSG00000100577" "GSTZ1" "A6NED0; A6NNB8; A8MWD7; B2RCK3; hsa:2954; O15308; O43708; O75430; Q6IB17; Q7Z610; Q9BV63" "Metapathway biotransformation Phase I and II" "Regulation of pyruvate dehydrogenase (PDH) complex; Glutathione conjugation; Tyrosine catabolism" "4" "0" "1.011" "1.040" "0.983" "1.063" "0.938" "1.003" "0.981" "0.983" "0.842" "1140.2" "1152.8" "1185.9" "1120.8" "1212.2" "1070.0" "1143.4" "1118.4" "1121.3" "959.8" "" "" "" "" "" "" "" "" "" "" "1025.2" "932.8" "1072.7" "1094.0" "1000.3" "1070.0" "856.2" "987.9" "1003.4" "342.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7283076570857654598" "False" "High" "IsMasterProtein" "Q96F44" "E3 ubiquitin-protein ligase TRIM11 OS=Homo sapiens OX=9606 GN=TRIM11 PE=1 SV=2" "0.000" "False" "24.617" "19" "8" "9" "8" "468" "52.7" "5.69" "30.69" "8" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf00643, Pf13765, Pf15227" "81559" "ENSG00000154370" "TRIM11" "A6NKE2; B2RB82; B3KUS3; B4DX88; hsa:81559; Q5VSU1; Q8NCA6; Q96F44; Q9C022" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.111" "1.160" "1.028" "1.156" "1.186" "1.104" "1.111" "1.046" "1.143" "355.4" "395.0" "412.2" "365.3" "410.8" "421.4" "392.5" "394.9" "371.6" "406.1" "" "" "" "" "" "" "" "" "" "" "319.6" "319.6" "372.9" "356.6" "339.0" "421.4" "293.9" "348.8" "332.5" "145.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4980915021063436064" "False" "High" "IsMasterProtein" "Q9H944" "Mediator of RNA polymerase II transcription subunit 20 OS=Homo sapiens OX=9606 GN=MED20 PE=1 SV=1" "0.000" "False" "24.597" "36" "7" "7" "7" "212" "23.2" "6.87" "27.51" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08612" "9477" "ENSG00000124641" "MED20" "B4DE08; hsa:9477; O95821; Q5T8J4; Q9H944; Q9Y429" "" "Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.995" "1.039" "0.955" "1.010" "1.073" "1.042" "0.962" "1.046" "1.099" "840.3" "836.0" "873.2" "802.1" "848.8" "901.3" "875.4" "808.7" "879.1" "923.8" "" "" "" "" "" "" "" "" "" "" "755.5" "676.5" "789.8" "783.0" "700.4" "901.3" "655.5" "714.3" "786.6" "329.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119616111706856744" "False" "High" "IsMasterProtein" "Q9ULZ3" "Apoptosis-associated speck-like protein containing a CARD OS=Homo sapiens OX=9606 GN=PYCARD PE=1 SV=2" "0.000" "False" "24.592" "31" "6" "10" "6" "195" "21.6" "6.34" "33.60" "6" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00619, Pf02758" "29108" "ENSG00000103490" "PYCARD" "hsa:29108; Q96D12; Q9BSZ5; Q9HBD0; Q9NXJ8; Q9ULZ3" "Nucleotide-binding oligomerization domain (NOD) pathway; Nanomaterial-induced inflammasome activation; TYROBP causal network in microglia; Acute viral myocarditis; Cytosolic DNA-sensing pathway; Activation of NLRP3 inflammasome by SARS-CoV-2; Prostaglandin signaling" "Neutrophil degranulation; The AIM2 inflammasome; The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; SARS-CoV-1 activates/modulates innate immune responses; CLEC7A/inflammasome pathway" "13" "0" "1.020" "0.953" "0.979" "1.050" "0.952" "1.037" "1.013" "0.977" "0.796" "1091.2" "1113.5" "1039.6" "1068.3" "1145.3" "1038.6" "1131.9" "1105.2" "1065.6" "869.1" "" "" "" "" "" "" "" "" "" "" "981.1" "901.0" "940.4" "1042.8" "945.2" "1038.6" "847.5" "976.2" "953.5" "310.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8834965082719872925" "False" "High" "IsMasterProtein" "Q96EQ0" "Small glutamine-rich tetratricopeptide repeat-containing protein beta OS=Homo sapiens OX=9606 GN=SGTB PE=1 SV=1" "0.000" "False" "24.584" "27" "6" "7" "6" "304" "33.4" "4.92" "23.93" "6" "cell organization and biogenesis;other biological processes" "other membranes;cytosol" "other molecular function" "Pf00515, Pf13414, Pf16546" "54557" "ENSG00000197860" "SGTB" "hsa:54557; Q96EQ0" "" "" "0" "0" "0.945" "1.071" "0.984" "0.979" "0.994" "1.039" "1.037" "1.062" "0.969" "488.1" "461.2" "522.8" "480.1" "477.9" "485.1" "507.1" "506.1" "518.5" "473.0" "" "" "" "" "" "" "" "" "" "" "438.9" "373.2" "472.9" "468.6" "394.3" "485.1" "379.7" "447.0" "463.9" "168.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3564822305630524625" "False" "High" "IsMasterProtein" "Q96M27" "Protein PRRC1 OS=Homo sapiens OX=9606 GN=PRRC1 PE=1 SV=1" "0.000" "False" "24.578" "11" "5" "10" "5" "445" "46.7" "5.83" "35.06" "5" "" "ER/Golgi;other cell component" "other molecular function" "Pf01931" "133619" "ENSG00000164244" "PRRC1" "hsa:133619; Q69YM8; Q7L2U7; Q86Y42; Q8IVJ4; Q8IVL4; Q8NEZ7; Q96AJ3; Q96M27" "" "" "0" "0" "1.069" "0.975" "1.005" "0.965" "0.952" "0.961" "1.003" "0.998" "0.778" "1392.7" "1489.4" "1357.3" "1399.7" "1344.1" "1326.3" "1338.6" "1396.4" "1389.4" "1084.0" "" "" "" "" "" "" "" "" "" "" "1252.2" "1205.2" "1227.8" "1366.3" "1109.2" "1326.3" "1002.3" "1233.4" "1243.2" "387.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2918128559095144433" "False" "High" "IsMasterProtein" "Q9NRA8" "Eukaryotic translation initiation factor 4E transporter OS=Homo sapiens OX=9606 GN=EIF4ENIF1 PE=1 SV=2" "0.000" "False" "24.537" "8" "8" "8" "8" "985" "108.1" "8.32" "25.67" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10477" "56478" "ENSG00000184708" "EIF4ENIF1" "B1AKL2; B1AKL3; B2RBF1; hsa:56478; Q8NCF2; Q9H708; Q9NRA8" "Primary ovarian insufficiency; 10q11.21q11.23 copy number variation syndrome" "" "2" "0" "1.039" "0.932" "0.989" "1.063" "1.017" "1.115" "0.978" "0.971" "1.167" "716.2" "743.7" "667.6" "708.4" "761.3" "728.7" "798.5" "700.5" "695.5" "836.0" "" "" "" "" "" "" "" "" "" "" "643.9" "601.8" "603.8" "691.5" "628.3" "728.7" "597.9" "618.8" "622.3" "298.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1616595542625436951" "False" "High" "IsMasterProtein" "Q96LR5" "Ubiquitin-conjugating enzyme E2 E2 OS=Homo sapiens OX=9606 GN=UBE2E2 PE=1 SV=1" "0.000" "False" "24.534" "31" "5" "10" "2" "201" "22.2" "7.71" "31.59" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00179" "7325" "ENSG00000182247" "UBE2E2" "hsa:7325; Q96LR5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "3" "1.056" "1.063" "0.947" "1.144" "1.064" "1.097" "1.027" "1.102" "1.127" "552.7" "583.6" "587.5" "523.4" "632.4" "588.0" "606.5" "567.5" "609.4" "623.1" "" "" "" "" "" "" "" "" "" "" "497.0" "472.2" "531.4" "510.9" "521.9" "588.0" "454.1" "501.2" "545.3" "222.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-383335111069342987" "False" "High" "IsMasterProtein" "Q6PD74" "Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens OX=9606 GN=AAGAB PE=1 SV=1" "0.000" "False" "24.513" "21" "5" "11" "5" "315" "34.6" "4.64" "35.55" "5" "transport" "cytosol;nucleus;other cell component" "" "Pf10199" "79719" "ENSG00000103591" "AAGAB" "B4DG44; hsa:79719; Q6FI86; Q6PD74; Q7Z5X9; Q9H0P1; Q9HAK0" "" "" "0" "0" "1.109" "1.046" "0.955" "1.045" "1.050" "1.116" "1.081" "1.163" "1.604" "238.0" "264.0" "248.9" "227.4" "248.8" "249.9" "265.7" "257.3" "276.8" "381.7" "" "" "" "" "" "" "" "" "" "" "214.0" "213.7" "225.2" "221.9" "205.3" "249.9" "198.9" "227.3" "247.7" "136.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3645624783218300571" "False" "High" "IsMasterProtein" "Q96CG3" "TRAF-interacting protein with FHA domain-containing protein A OS=Homo sapiens OX=9606 GN=TIFA PE=1 SV=1" "0.000" "False" "24.497" "25" "6" "9" "6" "184" "21.4" "5.11" "33.19" "6" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;other cell component" "" "Pf00498" "92610" "ENSG00000145365" "TIFA" "hsa:92610; Q96CG3" "Interleukin-1 induced activation of NF-kB; MYD88 distinct input-output pathway" "TAK1-dependent IKK and NF-kappa-B activation ; Alpha-protein kinase 1 signaling pathway" "4" "0" "1.087" "0.922" "1.124" "1.036" "1.112" "1.018" "1.019" "0.940" "0.881" "709.3" "771.2" "654.3" "797.0" "734.7" "788.8" "722.3" "723.1" "666.4" "625.3" "" "" "" "" "" "" "" "" "" "" "637.8" "624.0" "591.8" "777.9" "606.3" "788.8" "540.9" "638.7" "596.3" "223.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6008736440558391918" "False" "High" "IsMasterProtein" "O75157" "TSC22 domain family protein 2 OS=Homo sapiens OX=9606 GN=TSC22D2 PE=1 SV=3" "0.000" "False" "24.478" "9" "7" "9" "4" "780" "79.2" "5.02" "29.37" "7" "stress response;other biological processes" "" "" "Pf01166" "9819" "ENSG00000196428" "TSC22D2" "D3DNI5; hsa:9819; O75157; Q6PI50; Q9H2Z6; Q9H2Z7; Q9H2Z8" "" "" "0" "0" "0.975" "0.954" "0.858" "1.019" "0.987" "0.985" "0.923" "0.916" "0.871" "323.3" "315.3" "308.6" "277.5" "329.6" "319.3" "318.6" "298.5" "296.3" "281.8" "" "" "" "" "" "" "" "" "" "" "290.7" "255.1" "279.2" "270.9" "272.0" "319.3" "238.6" "263.7" "265.1" "100.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4485483695822680049" "False" "High" "IsMasterProtein" "Q9Y5R8" "Trafficking protein particle complex subunit 1 OS=Homo sapiens OX=9606 GN=TRAPPC1 PE=1 SV=1" "0.000" "False" "24.465" "40" "5" "7" "5" "145" "16.8" "9.16" "25.52" "5" "cell organization and biogenesis;transport" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04099" "58485" "ENSG00000170043" "TRAPPC1" "D3DTR0; hsa:58485; Q9Y5R8" "" "COPII-mediated vesicle transport; Neutrophil degranulation; RAB GEFs exchange GTP for GDP on RABs" "3" "0" "1.021" "1.016" "0.903" "1.037" "1.012" "1.084" "1.018" "1.019" "1.091" "607.8" "620.4" "617.5" "548.7" "630.5" "615.3" "659.1" "619.0" "619.3" "662.9" "" "" "" "" "" "" "" "" "" "" "546.5" "502.0" "558.5" "535.6" "520.3" "615.3" "493.5" "546.7" "554.2" "236.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3414895648230328268" "False" "High" "IsMasterProtein" "Q92667" "A-kinase anchor protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=AKAP1 PE=1 SV=1" "0.000" "False" "24.457" "11" "8" "9" "8" "903" "97.3" "4.94" "28.49" "8" "stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00013, Pf00567" "8165" "ENSG00000121057" "AKAP1" "A8K8Q1; D3DTZ0; hsa:8165; Q13320; Q92667; Q9BW14" "G protein signaling pathways" "Factors involved in megakaryocyte development and platelet production; Mitochondrial calcium ion transport" "3" "0" "0.979" "1.002" "1.048" "0.962" "1.011" "1.104" "1.004" "0.930" "1.205" "458.5" "448.8" "459.4" "480.3" "441.2" "463.7" "506.2" "460.3" "426.3" "552.5" "" "" "" "" "" "" "" "" "" "" "412.2" "363.1" "415.5" "468.9" "364.0" "463.7" "379.0" "406.5" "381.5" "197.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2594177095458516104" "False" "High" "IsMasterProtein" "P24386" "Rab proteins geranylgeranyltransferase component A 1 OS=Homo sapiens OX=9606 GN=CHM PE=1 SV=3" "0.000" "False" "24.422" "12" "7" "8" "7" "653" "73.4" "4.75" "24.32" "7" "protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00996" "1121" "ENSG00000188419" "CHM" "A1L4D2; hsa:1121; O43732; P24386" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "3" "0" "1.042" "0.950" "1.003" "1.109" "0.960" "1.016" "0.986" "1.046" "0.942" "394.3" "410.8" "374.5" "395.5" "437.1" "378.3" "400.7" "388.7" "412.3" "371.6" "" "" "" "" "" "" "" "" "" "" "354.5" "332.4" "338.7" "386.0" "360.7" "378.3" "300.0" "343.3" "368.9" "132.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5699619529489885522" "False" "High" "IsMasterProtein" "Q9Y250" "Leucine zipper putative tumor suppressor 1 OS=Homo sapiens OX=9606 GN=LZTS1 PE=1 SV=3" "0.000" "False" "24.406" "13" "7" "9" "7" "596" "66.6" "7.09" "24.92" "7" "cell cycle OR cell proliferation;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf06818" "11178" "ENSG00000061337" "LZTS1" "D3DSQ6; hsa:11178; Q9Y250; Q9Y5V7; Q9Y5V8; Q9Y5V9; Q9Y5W0; Q9Y5W1; Q9Y5W2" "" "" "0" "0" "0.979" "0.913" "0.947" "1.091" "0.910" "1.074" "1.006" "0.931" "1.133" "573.2" "561.1" "523.1" "542.7" "625.3" "521.5" "615.5" "576.6" "533.8" "649.7" "" "" "" "" "" "" "" "" "" "" "515.3" "454.0" "473.2" "529.8" "516.0" "521.5" "460.8" "509.3" "477.6" "231.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139328666383470964" "False" "High" "IsMasterProtein" "Q8IZH2" "5'-3' exoribonuclease 1 OS=Homo sapiens OX=9606 GN=XRN1 PE=1 SV=1" "0.000" "False" "24.382" "5" "8" "8" "8" "1706" "194.0" "7.21" "23.27" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03159, Pf17846, Pf18129, Pf18332, Pf18334" "54464" "ENSG00000114127" "XRN1" "hsa:54464; Q4G0S3; Q68D88; Q6AI24; Q6MZS8; Q86WS7; Q8IZH2; Q8N8U4; Q9UF39" "miRNA degrading enzymes" "mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "4" "0" "1.118" "0.945" "1.020" "1.286" "1.121" "1.173" "0.909" "1.136" "1.841" "182.6" "204.0" "172.6" "186.2" "234.7" "204.7" "214.2" "165.9" "207.3" "336.0" "" "" "" "" "" "" "" "" "" "" "164.1" "165.1" "156.1" "181.8" "193.7" "204.7" "160.4" "146.5" "185.5" "120.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933841314574218963" "False" "High" "IsMasterProtein" "Q99633" "Pre-mRNA-splicing factor 18 OS=Homo sapiens OX=9606 GN=PRPF18 PE=1 SV=1" "0.000" "False" "24.381" "23" "7" "8" "7" "342" "39.8" "8.15" "27.24" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf02840, Pf08799" "8559" "ENSG00000165630" "PRPF18" "hsa:8559; Q5T9P9; Q99633; Q9BUI9" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.001" "0.988" "0.952" "1.068" "0.952" "1.002" "0.951" "0.944" "1.351" "1081.4" "1082.0" "1068.0" "1029.7" "1154.5" "1029.7" "1083.2" "1028.3" "1020.3" "1461.2" "" "" "" "" "" "" "" "" "" "" "972.3" "875.5" "966.1" "1005.1" "952.7" "1029.7" "811.1" "908.3" "913.0" "521.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567249118239018231" "False" "High" "IsMasterProtein" "Q9C0B5" "Palmitoyltransferase ZDHHC5 OS=Homo sapiens OX=9606 GN=ZDHHC5 PE=1 SV=2" "0.000" "False" "24.351" "13" "7" "8" "7" "715" "77.5" "9.01" "29.65" "7" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01529" "25921" "ENSG00000156599" "ZDHHC5" "hsa:25921; Q2TGF0; Q6ZMF0; Q8TAK8; Q9C0B5; Q9H923; Q9UFI7" "" "Maturation of spike protein" "1" "0" "0.939" "1.009" "1.048" "0.939" "1.069" "1.014" "0.970" "1.014" "0.851" "451.2" "423.5" "455.3" "473.0" "423.8" "482.1" "457.4" "437.6" "457.7" "383.9" "" "" "" "" "" "" "" "" "" "" "405.7" "342.7" "411.9" "461.7" "349.8" "482.1" "342.5" "386.5" "409.6" "137.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1901322686263979467" "False" "High" "IsMasterProtein" "Q32P44" "Echinoderm microtubule-associated protein-like 3 OS=Homo sapiens OX=9606 GN=EML3 PE=1 SV=1" "0.000" "False" "24.331" "11" "7" "7" "7" "896" "95.1" "7.12" "30.26" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf03451" "256364" "ENSG00000149499" "EML3" "hsa:256364; Q32P44; Q6ZQW7; Q8NA55" "" "" "0" "0" "1.036" "1.056" "1.000" "0.947" "0.996" "1.015" "0.959" "1.011" "1.051" "459.3" "475.9" "484.8" "459.2" "434.8" "457.2" "466.2" "440.6" "464.1" "482.7" "" "" "" "" "" "" "" "" "" "" "412.9" "385.1" "438.5" "448.2" "358.8" "457.2" "349.1" "389.2" "415.3" "172.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1711766393091945325" "False" "High" "IsMasterProtein" "Q6DKK2" "Tetratricopeptide repeat protein 19, mitochondrial OS=Homo sapiens OX=9606 GN=TTC19 PE=1 SV=4" "0.000" "False" "24.321" "20" "6" "8" "6" "380" "42.4" "5.77" "33.34" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;cytoskeleton;mitochondrion;other cell component" "" "Pf13374, Pf13424" "54902" "ENSG00000011295" "TTC19" "A8MZ52; B3KP62; B4DN65; hsa:54902; Q2M248; Q6DKK2; Q7L3U8; Q9H6G3; Q9NXB2" "Mitochondrial complex III assembly" "" "1" "0" "0.934" "1.038" "0.931" "0.984" "0.993" "1.000" "0.956" "0.982" "1.040" "740.8" "691.7" "769.2" "689.7" "729.3" "735.8" "740.5" "708.3" "727.8" "770.4" "" "" "" "" "" "" "" "" "" "" "666.1" "559.7" "695.8" "673.2" "601.8" "735.8" "554.5" "625.6" "651.2" "275.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871299150167349072" "False" "High" "IsMasterProtein" "Q8TF68" "Zinc finger protein 384 OS=Homo sapiens OX=9606 GN=ZNF384 PE=1 SV=2" "0.000" "False" "24.313" "11" "5" "6" "5" "577" "63.2" "8.95" "30.20" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "171017" "ENSG00000126746" "ZNF384" "hsa:171017; O15407; Q7Z722; Q8N938; Q8TF68" "" "" "0" "0" "0.953" "0.874" "1.094" "0.934" "0.953" "1.051" "1.041" "0.892" "1.195" "588.1" "560.1" "514.2" "643.4" "549.4" "560.4" "617.8" "612.2" "524.3" "702.8" "" "" "" "" "" "" "" "" "" "" "528.7" "453.3" "465.1" "628.0" "453.4" "560.4" "462.6" "540.7" "469.1" "250.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531116507177860716" "False" "High" "IsMasterProtein" "Q06609" "DNA repair protein RAD51 homolog 1 OS=Homo sapiens OX=9606 GN=RAD51 PE=1 SV=1" "0.000" "False" "24.272" "26" "7" "7" "7" "339" "36.9" "5.60" "26.53" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423, Pf14520" "5888" "ENSG00000051180" "RAD51" "B0FXP0; B2R8T6; hsa:5888; Q06609; Q6FHX9; Q6ZNA8; Q9BV60" "miRNA regulation of DNA damage response; Homologous recombination; ATM signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; Breast cancer pathway; Pancreatic adenocarcinoma pathway; DNA repair pathways, full network; Primary ovarian insufficiency; DNA damage response" "Resolution of D-loop Structures through Holliday Junction Intermediates; Transcriptional Regulation by E2F6; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "23" "0" "1.032" "1.146" "0.955" "1.005" "1.040" "0.985" "0.990" "1.172" "1.006" "821.1" "847.1" "941.3" "784.2" "825.1" "854.3" "809.0" "813.2" "962.3" "825.6" "" "" "" "" "" "" "" "" "" "" "738.2" "685.5" "851.4" "765.5" "680.9" "854.3" "605.8" "718.3" "861.0" "294.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890760883318771042" "False" "High" "IsMasterProtein" "Q15653" "NF-kappa-B inhibitor beta OS=Homo sapiens OX=9606 GN=NFKBIB PE=1 SV=2" "0.000" "False" "24.192" "24" "6" "7" "6" "356" "37.7" "4.84" "31.81" "6" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00023, Pf13637" "4793" "ENSG00000104825; ENSG00000282905" "NFKBIB" "A8K3F4; hsa:4793; Q15653; Q96BJ7" "IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Apoptosis; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Toll-like receptor signaling pathway" "Activation of NF-kappaB in B cells; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation" "16" "0" "0.971" "0.929" "0.962" "1.038" "0.953" "0.985" "1.023" "0.947" "1.125" "1087.5" "1055.4" "1010.5" "1045.8" "1128.3" "1036.7" "1070.7" "1112.1" "1029.6" "1223.4" "" "" "" "" "" "" "" "" "" "" "977.8" "854.0" "914.1" "1020.8" "931.1" "1036.7" "801.7" "982.3" "921.3" "436.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5656121017139874826" "False" "High" "IsMasterProtein" "Q01081" "Splicing factor U2AF 35 kDa subunit OS=Homo sapiens OX=9606 GN=U2AF1 PE=1 SV=3" "0.000" "False" "24.169" "26" "5" "7" "5" "240" "27.9" "8.81" "27.07" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00642" "102724594; 7307" "ENSG00000160201" "U2AF1" "hsa:102724594; hsa:7307; Q01081; Q701P4; Q71RF1" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway" "5" "0" "0.945" "0.939" "0.945" "0.956" "1.096" "0.890" "0.913" "0.994" "1.259" "582.2" "550.0" "546.8" "550.0" "556.7" "638.0" "518.0" "531.6" "578.5" "733.0" "" "" "" "" "" "" "" "" "" "" "523.5" "445.0" "494.6" "536.9" "459.4" "638.0" "387.9" "469.6" "517.6" "261.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6656067604424276740" "False" "High" "IsMasterProtein" "O95365" "Zinc finger and BTB domain-containing protein 7A OS=Homo sapiens OX=9606 GN=ZBTB7A PE=1 SV=1" "0.000" "False" "24.162" "19" "5" "7" "5" "584" "61.4" "5.19" "31.85" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "51341" "ENSG00000178951" "ZBTB7A" "D6W619; hsa:51341; O00456; O95365; Q14D41; Q5XG86" "IL-18 signaling pathway" "" "1" "0" "0.981" "1.007" "1.046" "1.009" "1.134" "0.998" "1.044" "1.010" "1.096" "229.7" "225.2" "231.4" "240.4" "231.8" "260.5" "229.3" "239.9" "231.9" "251.7" "" "" "" "" "" "" "" "" "" "" "206.5" "182.3" "209.3" "234.6" "191.3" "260.5" "171.7" "211.9" "207.5" "89.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6975409787188746590" "False" "High" "IsMasterProtein" "Q7L513" "Fc receptor-like A OS=Homo sapiens OX=9606 GN=FCRLA PE=1 SV=2" "0.000" "False" "24.092" "14" "5" "11" "5" "359" "38.9" "5.36" "39.13" "5" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13895" "84824" "ENSG00000132185" "FCRLA" "A0N0M1; A6NC03; A6NL20; F5H720; F8W743; G3V1J2; hsa:84824; Q5VXA1; Q5VXA2; Q5VXA3; Q5VXA4; Q5VXB0; Q5VXB1; Q7L513; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1; Q96PJ2; Q96PJ4; Q9BR57" "" "" "0" "0" "1.015" "1.045" "1.045" "1.030" "1.103" "1.102" "1.083" "1.109" "1.151" "807.0" "819.1" "843.0" "843.1" "831.2" "889.9" "889.1" "874.0" "895.1" "928.7" "" "" "" "" "" "" "" "" "" "" "725.5" "662.8" "762.5" "823.0" "685.9" "889.9" "665.7" "771.9" "801.0" "331.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7569413463716614588" "False" "High" "IsMasterProtein" "Q8N6M0" "Deubiquitinase OTUD6B OS=Homo sapiens OX=9606 GN=OTUD6B PE=1 SV=1" "0.000" "False" "24.069" "29" "7" "10" "7" "293" "33.8" "6.05" "37.71" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "" "other molecular function" "Pf02338" "51633" "ENSG00000155100" "OTUD6B" "A8K6I1; B4DEY0; hsa:51633; Q8N6M0; Q9NTA4; Q9Y387" "Warburg effect modulated by deubiquitinating enzymes and their substrates" "" "1" "0" "0.969" "0.994" "1.006" "1.056" "0.986" "1.035" "0.973" "0.934" "1.548" "820.9" "795.2" "815.9" "825.6" "866.5" "809.2" "849.6" "798.7" "766.9" "1271.1" "" "" "" "" "" "" "" "" "" "" "738.1" "643.4" "738.0" "805.9" "715.1" "809.2" "636.2" "705.5" "686.2" "453.8" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8443695202608012138" "False" "High" "IsMasterProtein" "P49796" "Regulator of G-protein signaling 3 OS=Homo sapiens OX=9606 GN=RGS3 PE=1 SV=2" "0.000" "False" "24.029" "8" "7" "9" "7" "1198" "132.3" "6.28" "33.52" "7" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00168, Pf00595, Pf00615" "5998" "ENSG00000138835" "RGS3" "A6NHA0; A8K0V1; B3KUB2; hsa:5998; P49796; Q5VXB8; Q5VXC1; Q5VZ05; Q5VZ06; Q6ZRM5; Q8IUQ1; Q8NC47; Q8NFN4; Q8NFN5; Q8NFN6; Q8TD59; Q8TD68; Q8WV02; Q8WXA0" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (q) signalling events; G alpha (i) signalling events" "4" "0" "0.933" "0.896" "1.011" "0.992" "0.971" "1.024" "0.981" "0.931" "2.663" "529.9" "494.7" "474.8" "535.8" "525.6" "514.7" "542.7" "519.6" "493.6" "1411.1" "" "" "" "" "" "" "" "" "" "" "476.4" "400.3" "429.5" "523.0" "433.8" "514.7" "406.3" "459.0" "441.6" "503.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396940342238216990" "False" "High" "IsMasterProtein" "Q9H6Y2" "WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2" "0.000" "False" "24.015" "20" "5" "6" "5" "383" "42.0" "4.92" "24.70" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf00400, Pf12894" "54853" "ENSG00000120314" "WDR55" "hsa:54853; Q9H6Y2; Q9NXK4" "" "" "0" "0" "0.951" "0.973" "0.919" "0.942" "0.915" "0.895" "0.878" "0.887" "0.759" "480.6" "457.2" "467.8" "441.4" "452.5" "439.8" "430.0" "422.0" "426.2" "364.9" "" "" "" "" "" "" "" "" "" "" "432.1" "370.0" "423.2" "430.9" "373.4" "439.8" "322.0" "372.7" "381.4" "130.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-912573818931081677" "False" "High" "IsMasterProtein" "P48736" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PIK3CG PE=1 SV=3" "0.000" "False" "24.014" "6" "7" "8" "7" "1102" "126.4" "7.50" "21.58" "7" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf19710" "5294" "ENSG00000105851" "PIK3CG" "A4D0Q6; hsa:5294; P48736; Q8IV23; Q9BZC8" "IL-5 signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Prolactin signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; BDNF-TrkB signaling; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Regulation of apoptosis by parathyroid hormone-related protein; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Head and neck squamous cell carcinoma; Osteoblast differentiation and related diseases; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Kisspeptin/kisspeptin receptor system in the ovary; Pleural mesothelioma; Prostaglandin signaling; Opioid receptor pathways; Regulation of actin cytoskeleton; EPO receptor signaling; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Synthesis of PIPs at the plasma membrane; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); GPVI-mediated activation cascade; G beta:gamma signalling through PI3Kgamma; Signaling by CSF1 (M-CSF) in myeloid cells" "40" "0" "1.120" "0.964" "0.936" "1.100" "1.012" "1.144" "1.066" "1.101" "2.549" "312.4" "349.8" "301.1" "292.3" "343.5" "316.2" "357.5" "333.1" "343.8" "796.2" "" "" "" "" "" "" "" "" "" "" "280.8" "283.0" "272.3" "285.3" "283.4" "316.2" "267.7" "294.2" "307.7" "284.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774466273942528480" "False" "High" "IsMasterProtein" "O43379" "WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4" "0.000" "False" "23.996" "7" "9" "9" "9" "1518" "165.8" "5.91" "25.21" "9" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "" "Pf00400" "284403" "ENSG00000075702" "WDR62" "hsa:284403; O43379; Q63HP9; Q659D7; Q8NBF7; Q96AD9" "Primary ovarian insufficiency" "" "1" "0" "1.038" "1.096" "0.984" "1.018" "0.990" "0.951" "0.944" "1.099" "1.294" "440.1" "457.0" "482.4" "433.1" "447.9" "435.6" "418.7" "415.5" "483.7" "569.5" "" "" "" "" "" "" "" "" "" "" "395.7" "369.8" "436.4" "422.8" "369.6" "435.6" "313.5" "367.0" "432.8" "203.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4669719094448447392" "False" "High" "IsMasterProtein" "Q9BSJ8" "Extended synaptotagmin-1 OS=Homo sapiens OX=9606 GN=ESYT1 PE=1 SV=1" "0.000" "False" "23.980" "6" "6" "7" "6" "1104" "122.8" "5.83" "28.65" "6" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00168, Pf17047" "23344" "ENSG00000139641" "ESYT1" "A0FGR7; A8K2S2; hsa:23344; O94848; Q6PJN4; Q9BSJ8; Q9H6J1; Q9H6W2; Q9Y416" "" "RHOG GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Glycosphingolipid transport; RHOD GTPase cycle; RHOF GTPase cycle" "7" "0" "1.108" "0.982" "1.006" "1.198" "1.140" "1.314" "1.096" "0.935" "1.258" "452.3" "501.3" "444.0" "454.8" "541.8" "515.6" "594.5" "495.6" "422.8" "568.8" "" "" "" "" "" "" "" "" "" "" "406.6" "405.6" "401.6" "444.0" "447.1" "515.6" "445.1" "437.8" "378.3" "203.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1343964700997120443" "False" "High" "IsMasterProtein" "O94830" "Phospholipase DDHD2 OS=Homo sapiens OX=9606 GN=DDHD2 PE=1 SV=2" "0.000" "False" "23.956" "12" "7" "7" "7" "711" "81.0" "5.39" "23.69" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00536, Pf02825, Pf02862" "23259" "ENSG00000085788" "DDHD2" "B3KWV2; B3KXB5; hsa:23259; O94830; Q9H8X7" "" "Synthesis of PA" "1" "0" "0.976" "0.968" "0.932" "0.979" "0.926" "1.004" "0.941" "0.892" "1.284" "325.5" "317.6" "315.2" "303.4" "318.6" "301.5" "327.0" "306.2" "290.3" "417.9" "" "" "" "" "" "" "" "" "" "" "292.7" "257.0" "285.1" "296.1" "262.9" "301.5" "244.8" "270.5" "259.8" "149.2" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1508959840554036408" "False" "High" "IsMasterProtein" "Q969V6" "Myocardin-related transcription factor A OS=Homo sapiens OX=9606 GN=MRTFA PE=1 SV=1" "0.000" "False" "23.901" "8" "7" "9" "5" "931" "98.9" "5.86" "32.83" "7" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02037, Pf02755" "57591" "ENSG00000196588" "MRTFA" "hsa:57591; Q8TCL1; Q969V6; Q96SC5; Q96SC6; Q9P2B0" "" "RHO GTPases Activate Formins; SUMOylation of transcription cofactors" "2" "0" "1.062" "1.021" "1.112" "1.118" "1.113" "1.181" "1.140" "1.059" "1.236" "336.6" "357.4" "343.7" "374.4" "376.2" "374.6" "397.6" "383.7" "356.5" "416.0" "" "" "" "" "" "" "" "" "" "" "302.6" "289.2" "310.9" "365.5" "310.5" "374.6" "297.7" "338.9" "319.0" "148.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758284595644048114" "False" "High" "IsMasterProtein" "P78345" "Ribonuclease P protein subunit p38 OS=Homo sapiens OX=9606 GN=RPP38 PE=1 SV=2" "0.000" "False" "23.869" "20" "5" "6" "5" "283" "31.8" "9.92" "25.77" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01248" "10557" "ENSG00000152464" "RPP38" "B3KPY0; D3DRT8; hsa:10557; P78345; Q53F71; Q8NHS8" "Sphingolipid metabolism in senescence" "Major pathway of rRNA processing in the nucleolus and cytosol; tRNA processing in the nucleus" "3" "0" "1.025" "0.951" "0.951" "1.158" "1.047" "1.079" "1.037" "0.960" "0.884" "320.9" "328.9" "305.2" "305.0" "371.5" "336.0" "346.4" "332.8" "308.1" "283.6" "" "" "" "" "" "" "" "" "" "" "288.5" "266.1" "276.1" "297.7" "306.6" "336.0" "259.4" "293.9" "275.7" "101.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2000966759959030184" "False" "High" "IsMasterProtein" "Q9H267" "Vacuolar protein sorting-associated protein 33B OS=Homo sapiens OX=9606 GN=VPS33B PE=1 SV=2" "0.000" "False" "23.867" "12" "7" "8" "7" "617" "70.5" "6.71" "29.10" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00995" "26276" "ENSG00000184056" "VPS33B" "B3KQF6; hsa:26276; Q96K14; Q9H267; Q9NRP6; Q9NSF3" "" "Prevention of phagosomal-lysosomal fusion; SARS-CoV-2 modulates autophagy" "2" "0" "0.953" "1.010" "0.989" "0.926" "0.971" "0.971" "0.899" "0.905" "1.920" "400.6" "381.7" "404.6" "396.4" "371.0" "388.9" "389.0" "360.1" "362.8" "769.2" "" "" "" "" "" "" "" "" "" "" "360.2" "308.9" "366.0" "386.9" "306.2" "388.9" "291.3" "318.1" "324.6" "274.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "515980508248597386" "False" "High" "IsMasterProtein" "Q5T1V6" "Probable ATP-dependent RNA helicase DDX59 OS=Homo sapiens OX=9606 GN=DDX59 PE=1 SV=1" "0.000" "False" "23.863" "16" "8" "8" "8" "619" "68.8" "7.44" "25.52" "8" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04438" "83479" "ENSG00000118197" "DDX59" "hsa:83479; Q5T1V6; Q6PJL2; Q8IVW3; Q9H0W3" "Ciliopathies" "" "1" "0" "1.073" "1.046" "1.002" "1.101" "1.075" "1.107" "1.056" "1.091" "1.038" "723.5" "776.2" "756.9" "724.7" "796.6" "777.9" "801.1" "764.3" "789.5" "750.8" "" "" "" "" "" "" "" "" "" "" "650.5" "628.1" "684.6" "707.4" "657.4" "777.9" "599.8" "675.1" "706.4" "268.0" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8383359941094889164" "False" "High" "IsMasterProtein" "Q9NV35" "Nucleotide triphosphate diphosphatase NUDT15 OS=Homo sapiens OX=9606 GN=NUDT15 PE=1 SV=1" "0.000" "False" "23.860" "54" "6" "9" "6" "164" "18.6" "6.14" "35.71" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol" "other molecular function" "Pf00293" "55270" "ENSG00000136159" "NUDT15" "A2RUR6; hsa:55270; Q32Q27; Q6P2C9; Q9NV35" "" "Azathioprine ADME; Phosphate bond hydrolysis by NUDT proteins" "2" "0" "0.975" "0.962" "0.999" "1.026" "1.010" "1.002" "0.990" "1.009" "0.818" "943.9" "920.4" "907.8" "943.3" "968.9" "953.2" "946.3" "934.4" "952.4" "772.0" "" "" "" "" "" "" "" "" "" "" "848.7" "744.7" "821.1" "920.8" "799.5" "953.2" "708.6" "825.3" "852.2" "275.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2516739525907873838" "False" "High" "IsMasterProtein" "Q96RN5" "Mediator of RNA polymerase II transcription subunit 15 OS=Homo sapiens OX=9606 GN=MED15 PE=1 SV=2" "0.000" "False" "23.830" "8" "6" "9" "6" "788" "86.7" "9.42" "29.24" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09606, Pf21538, Pf21539" "51586" "ENSG00000099917" "MED15" "D3DX31; D3DX32; hsa:51586; O15413; Q6IC31; Q8NF16; Q96CT0; Q96IH7; Q96RN5; Q9P1T3" "Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; 22q11.2 copy number variation syndrome" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "7" "0" "1.026" "1.054" "0.974" "1.140" "1.164" "1.077" "1.087" "1.175" "1.139" "429.3" "440.5" "452.5" "417.9" "489.4" "499.6" "462.1" "466.5" "504.2" "489.1" "" "" "" "" "" "" "" "" "" "" "386.0" "356.5" "409.3" "407.9" "403.9" "499.6" "346.0" "412.0" "451.2" "174.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559199072785365377" "False" "High" "IsMasterProtein" "Q14493" "Histone RNA hairpin-binding protein OS=Homo sapiens OX=9606 GN=SLBP PE=1 SV=1" "0.000" "False" "23.826" "24" "6" "10" "6" "270" "31.3" "7.47" "27.73" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15247" "7884" "ENSG00000163950" "SLBP" "B3KRJ5; hsa:7884; Q14493" "8p23.1 copy number variation syndrome; 4p16.3 copy number variation" "RNA Polymerase II Transcription Termination; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs; Transport of the SLBP Dependant Mature mRNA" "5" "0" "1.019" "1.455" "1.004" "0.975" "1.403" "0.974" "0.905" "1.486" "1.962" "279.8" "285.1" "407.2" "281.0" "272.7" "392.6" "272.6" "253.2" "415.9" "549.2" "" "" "" "" "" "" "" "" "" "" "251.6" "230.7" "368.3" "274.3" "225.1" "392.6" "204.1" "223.7" "372.1" "196.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-274346279625731140" "False" "High" "IsMasterProtein" "O00471" "Exocyst complex component 5 OS=Homo sapiens OX=9606 GN=EXOC5 PE=1 SV=1" "0.000" "False" "23.826" "10" "7" "7" "7" "708" "81.8" "6.71" "27.00" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf07393, Pf20667" "10640" "ENSG00000070367" "EXOC5" "B2R6C5; hsa:10640; O00471; Q8IW24" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.082" "1.309" "0.991" "1.145" "1.044" "1.126" "0.898" "1.070" "1.853" "113.8" "123.1" "149.0" "112.7" "130.3" "118.8" "128.1" "102.2" "121.8" "210.9" "" "" "" "" "" "" "" "" "" "" "102.3" "99.6" "134.8" "110.0" "107.6" "118.8" "95.9" "90.2" "109.0" "75.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9008676394331225875" "False" "High" "IsMasterProtein" "Q9ULV3" "Cip1-interacting zinc finger protein OS=Homo sapiens OX=9606 GN=CIZ1 PE=1 SV=2" "0.000" "False" "23.826" "8" "5" "8" "5" "898" "100.0" "6.11" "27.63" "5" "other biological processes" "plasma membrane;other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "25792" "ENSG00000148337" "CIZ1" "A8K9J8; B4E131; B7ZAS8; hsa:25792; Q5SYW3; Q5SYW5; Q8WU72; Q9H868; Q9NYM8; Q9UHK4; Q9ULV3; Q9Y3F9; Q9Y3G0" "" "" "0" "0" "1.120" "1.027" "1.114" "1.204" "1.120" "1.335" "1.111" "0.912" "0.995" "168.4" "188.6" "173.0" "187.6" "202.7" "188.6" "224.8" "187.1" "153.6" "167.5" "" "" "" "" "" "" "" "" "" "" "151.4" "152.6" "156.5" "183.1" "167.3" "188.6" "168.4" "165.3" "137.4" "59.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8489357358395881882" "False" "High" "IsMasterProtein" "Q86SX6" "Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX5 PE=1 SV=2" "0.000" "False" "23.816" "32" "4" "13" "4" "157" "16.6" "6.79" "46.39" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00462" "51218" "ENSG00000182512" "GLRX5" "hsa:51218; Q0X088; Q3YML0; Q86SX6; Q86WY3; Q8IZ54" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "0.881" "0.952" "0.933" "1.007" "0.886" "0.945" "0.993" "0.944" "0.786" "1102.3" "970.7" "1049.0" "1027.9" "1110.4" "976.5" "1041.6" "1094.1" "1040.1" "866.4" "" "" "" "" "" "" "" "" "" "" "991.1" "785.4" "948.9" "1003.4" "916.3" "976.5" "779.9" "966.4" "930.7" "309.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1023835603968378243" "False" "High" "IsMasterProtein" "O75506" "Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1" "0.000" "False" "23.812" "49" "3" "13" "3" "76" "8.5" "4.36" "51.66" "3" "stress response;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06825" "3281" "ENSG00000230989" "HSBP1" "hsa:3281; O75506; Q53XA8; Q7Z5Z3" "" "HSF1 activation; Attenuation phase" "3" "0" "0.906" "0.975" "0.926" "1.068" "1.053" "1.053" "1.036" "1.074" "0.869" "722.9" "655.2" "705.2" "669.3" "771.9" "761.4" "760.9" "748.8" "776.2" "628.5" "" "" "" "" "" "" "" "" "" "" "650.0" "530.2" "637.8" "653.3" "637.0" "761.4" "569.8" "661.4" "694.5" "224.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5846443296709188562" "False" "High" "IsMasterProtein" "Q9Y248" "DNA replication complex GINS protein PSF2 OS=Homo sapiens OX=9606 GN=GINS2 PE=1 SV=1" "0.000" "False" "23.803" "35" "6" "10" "6" "185" "21.4" "5.44" "31.70" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus" "" "Pf05916" "51659" "ENSG00000131153" "GINS2" "D3DUM5; hsa:51659; Q6IAG9; Q9Y248" "" "Unwinding of DNA" "1" "0" "1.012" "1.027" "0.963" "1.000" "1.000" "1.092" "1.017" "1.023" "1.019" "667.6" "675.7" "685.5" "642.8" "667.7" "667.6" "728.8" "679.0" "682.9" "680.3" "" "" "" "" "" "" "" "" "" "" "600.2" "546.8" "620.1" "627.5" "551.0" "667.6" "545.7" "599.8" "611.1" "242.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5314014285931232470" "False" "High" "IsMasterProtein" "P18124" "Large ribosomal subunit protein uL30 OS=Homo sapiens OX=9606 GN=RPL7 PE=1 SV=1" "0.000" "False" "23.801" "25" "6" "10" "6" "248" "29.2" "10.65" "31.21" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00327, Pf08079" "6129" "ENSG00000147604" "RPL7" "A8K504; hsa:6129; P18124; Q15289; Q3KQU0; Q5I0X1; Q6IBM9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.006" "0.930" "0.904" "1.111" "0.904" "0.918" "1.046" "0.917" "0.494" "289.0" "290.8" "268.9" "261.2" "321.0" "261.2" "265.3" "302.2" "264.9" "142.7" "" "" "" "" "" "" "" "" "" "" "259.8" "235.3" "243.2" "255.0" "264.9" "261.2" "198.7" "266.9" "237.1" "50.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1189012646270467424" "False" "High" "IsMasterProtein" "Q9H5Q4" "Dimethyladenosine transferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=TFB2M PE=1 SV=1" "0.000" "False" "23.756" "17" "7" "8" "7" "396" "45.3" "9.19" "26.78" "7" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00398" "64216" "ENSG00000162851" "TFB2M" "hsa:64216; Q9H5Q4; Q9H626" "Energy metabolism; Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "4" "0" "1.033" "1.002" "0.946" "1.048" "1.016" "1.015" "1.038" "0.980" "0.922" "642.8" "664.0" "644.4" "608.3" "673.6" "653.3" "652.5" "667.0" "630.2" "592.8" "" "" "" "" "" "" "" "" "" "" "578.0" "537.3" "582.9" "593.7" "555.9" "653.3" "488.6" "589.1" "563.9" "211.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-618905356124197811" "False" "High" "IsMasterProtein" "Q9NQZ5" "StAR-related lipid transfer protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=STARD7 PE=1 SV=2" "0.000" "False" "23.748" "19" "7" "12" "7" "370" "43.1" "8.95" "34.73" "7" "" "other membranes;mitochondrion" "other molecular function" "Pf01852" "56910" "ENSG00000084090" "STARD7" "D3DXG9; hsa:56910; Q53T44; Q6GU43; Q969M6; Q9NQZ5" "2q11.2 copy number variation syndrome" "Mitochondrial protein degradation; Synthesis of PC" "3" "0" "1.056" "1.019" "1.031" "0.973" "1.006" "1.027" "0.953" "1.002" "0.973" "642.4" "678.7" "654.3" "662.1" "625.0" "646.0" "659.5" "612.2" "644.0" "625.1" "" "" "" "" "" "" "" "" "" "" "577.6" "549.2" "591.9" "646.3" "515.7" "646.0" "493.8" "540.7" "576.2" "223.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6049442156646566229" "False" "High" "IsMasterProtein" "Q6UXN9" "WD repeat-containing protein 82 OS=Homo sapiens OX=9606 GN=WDR82 PE=1 SV=1" "0.000" "False" "23.748" "22" "8" "9" "8" "313" "35.1" "7.69" "30.93" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "80335" "ENSG00000164091" "WDR82" "A8K5R5; hsa:80335; Q6UXN9; Q8TEB2" "" "Formation of WDR5-containing histone-modifying complexes" "1" "0" "1.055" "1.087" "0.990" "1.091" "1.074" "1.089" "1.008" "1.096" "0.881" "584.1" "616.5" "635.0" "578.3" "637.2" "627.4" "636.1" "589.0" "640.4" "514.8" "" "" "" "" "" "" "" "" "" "" "525.2" "498.9" "574.4" "564.5" "525.8" "627.4" "476.3" "520.2" "573.0" "183.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7752338987200815694" "False" "High" "IsMasterProtein" "Q9NQT4" "Exosome complex component RRP46 OS=Homo sapiens OX=9606 GN=EXOSC5 PE=1 SV=1" "0.000" "False" "23.748" "32" "6" "9" "6" "235" "25.2" "7.59" "29.60" "6" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "56915" "ENSG00000077348" "EXOSC5" "hsa:56915; Q32Q81; Q8NG16; Q96I89; Q9NQT4" "" "ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Major pathway of rRNA processing in the nucleolus and cytosol; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.033" "1.085" "1.024" "1.118" "1.043" "1.117" "1.095" "1.053" "0.808" "447.9" "462.8" "485.8" "458.6" "500.8" "467.3" "500.1" "490.5" "471.6" "361.9" "" "" "" "" "" "" "" "" "" "" "402.7" "374.5" "439.4" "447.6" "413.3" "467.3" "374.4" "433.3" "422.0" "129.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1581896134396951467" "False" "High" "IsMasterProtein" "P49006" "MARCKS-related protein OS=Homo sapiens OX=9606 GN=MARCKSL1 PE=1 SV=2" "0.000" "False" "23.739" "18" "4" "17" "4" "195" "19.5" "4.67" "64.17" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf02063" "65108" "ENSG00000175130" "MARCKSL1" "D3DPQ0; hsa:65108; P49006; Q5TEE6; Q6NXS5" "" "" "0" "0" "0.945" "0.928" "0.960" "0.889" "0.921" "0.946" "1.019" "0.865" "0.708" "1942.8" "1836.1" "1803.8" "1864.8" "1727.1" "1789.3" "1838.1" "1979.2" "1680.4" "1375.4" "" "" "" "" "" "" "" "" "" "" "1746.7" "1485.7" "1631.6" "1820.3" "1425.3" "1789.3" "1376.3" "1748.2" "1503.7" "491.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8764284085983728716" "False" "High" "IsMasterProtein" "P18583" "Protein SON OS=Homo sapiens OX=9606 GN=SON PE=1 SV=4" "0.000" "False" "23.737" "3" "6" "7" "5" "2426" "263.7" "5.64" "25.18" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf14709, Pf17069" "6651" "ENSG00000159140" "SON" "D3DSF5; D3DSF6; E7ETE8; E7EU67; E7EVW3; E9PFQ2; hsa:6651; O14487; O95981; P18583; Q14120; Q6PKE0; Q9H7B1; Q9P070; Q9P072; Q9UKP9; Q9UPY0" "" "" "0" "0" "1.047" "0.913" "0.994" "1.123" "1.002" "1.146" "0.964" "1.004" "1.967" "376.1" "393.9" "343.3" "373.9" "422.5" "377.0" "430.9" "362.7" "377.6" "739.7" "" "" "" "" "" "" "" "" "" "" "338.2" "318.8" "310.5" "365.0" "348.6" "377.0" "322.6" "320.3" "337.9" "264.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1759740052719989179" "False" "High" "IsMasterProtein" "O14561" "Acyl carrier protein, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAB1 PE=1 SV=3" "0.000" "False" "23.720" "19" "3" "18" "3" "156" "17.4" "4.93" "62.51" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;nucleus" "translation activity;other molecular function" "Pf00550" "4706" "ENSG00000004779" "NDUFAB1" "B2R4M1; O14561; Q9UNV1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Glyoxylate metabolism and glycine degradation; Mitochondrial Fatty Acid Beta-Oxidation; Complex I biogenesis" "7" "0" "0.918" "0.936" "0.960" "0.968" "0.938" "0.925" "1.002" "0.979" "0.753" "1647.5" "1511.9" "1541.4" "1581.5" "1594.6" "1545.2" "1524.5" "1651.0" "1612.5" "1240.4" "" "" "" "" "" "" "" "" "" "" "1481.2" "1223.4" "1394.2" "1543.7" "1315.9" "1545.2" "1141.5" "1458.3" "1442.8" "442.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5388836657935240768" "False" "High" "IsMasterProtein" "Q12872" "Splicing factor, suppressor of white-apricot homolog OS=Homo sapiens OX=9606 GN=SFSWAP PE=1 SV=3" "0.000" "False" "23.717" "8" "7" "9" "7" "951" "104.8" "8.05" "22.29" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf01805, Pf09750" "6433" "ENSG00000061936" "SFSWAP" "B2RN45; B7ZM97; F5H6B8; hsa:6433; Q12872; Q6PJF7" "mRNA processing" "" "1" "0" "1.018" "1.074" "0.958" "1.115" "1.085" "1.071" "1.036" "1.017" "1.003" "417.3" "424.7" "448.4" "399.8" "465.2" "452.9" "447.0" "432.2" "424.5" "418.8" "" "" "" "" "" "" "" "" "" "" "375.2" "343.6" "405.6" "390.3" "383.9" "452.9" "334.7" "381.7" "379.8" "149.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8332128719972757989" "False" "High" "IsMasterProtein" "Q8IY67" "Ribonucleoprotein PTB-binding 1 OS=Homo sapiens OX=9606 GN=RAVER1 PE=1 SV=1" "0.000" "False" "23.715" "10" "4" "9" "4" "606" "63.8" "8.48" "39.06" "4" "" "nucleus;other cell component" "" "Pf00076" "125950" "" "RAVER1" "A6NMU4; hsa:125950; Q8IY60; Q8IY67; Q8TF24" "" "" "0" "0" "0.973" "0.928" "0.937" "0.933" "0.960" "1.045" "0.992" "0.899" "2.769" "311.0" "302.5" "288.6" "291.3" "290.0" "298.4" "324.9" "308.6" "279.5" "861.1" "" "" "" "" "" "" "" "" "" "" "279.6" "244.8" "261.0" "284.4" "239.3" "298.4" "243.2" "272.6" "250.1" "307.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6246281522193444266" "False" "High" "IsMasterProtein" "O60573" "Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens OX=9606 GN=EIF4E2 PE=1 SV=1" "0.000" "False" "23.715" "23" "4" "7" "4" "245" "28.3" "8.88" "27.03" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01652" "9470" "ENSG00000135930" "EIF4E2" "B8ZZJ9; hsa:9470; O60573; O75349" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGFR tyrosine kinase inhibitor resistance" "ISG15 antiviral mechanism" "4" "0" "1.058" "1.007" "1.153" "1.049" "1.090" "1.141" "1.028" "1.070" "1.461" "504.0" "533.4" "507.6" "581.3" "528.5" "549.2" "575.1" "518.2" "539.3" "736.5" "" "" "" "" "" "" "" "" "" "" "453.1" "431.6" "459.1" "567.5" "436.1" "549.2" "430.6" "457.7" "482.6" "262.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4459716120349710015" "False" "High" "IsMasterProtein" "O14545" "TRAF-type zinc finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=TRAFD1 PE=1 SV=1" "0.000" "False" "23.712" "13" "7" "10" "7" "582" "64.8" "5.29" "25.79" "7" "other biological processes" "mitochondrion" "other molecular function" "Pf21366" "10906" "ENSG00000135148" "TRAFD1" "A8K5L6; B4DI89; hsa:10906; O14545" "" "" "0" "0" "0.910" "1.099" "0.910" "0.937" "1.018" "0.956" "0.991" "1.061" "1.156" "241.6" "219.9" "265.6" "219.9" "226.4" "246.1" "231.0" "239.5" "256.4" "279.4" "" "" "" "" "" "" "" "" "" "" "217.3" "177.9" "240.2" "214.7" "186.8" "246.1" "173.0" "211.6" "229.4" "99.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9194827022255966282" "False" "High" "IsMasterProtein" "Q9C0J8" "pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens OX=9606 GN=WDR33 PE=1 SV=2" "0.000" "False" "23.708" "7" "8" "10" "8" "1336" "145.8" "9.17" "22.81" "8" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf01391" "55339" "ENSG00000136709" "WDR33" "hsa:55339; Q05DP8; Q53FG9; Q587J1; Q69YF7; Q6NUQ0; Q9C0J8; Q9NUL1" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA Derived from an Intronless Transcript; Processing of Intronless Pre-mRNAs" "5" "0" "1.086" "1.074" "1.059" "1.104" "1.144" "1.147" "1.012" "0.904" "1.041" "586.8" "637.4" "630.5" "621.4" "647.8" "671.2" "673.1" "593.6" "530.7" "611.1" "" "" "" "" "" "" "" "" "" "" "527.6" "515.7" "570.3" "606.6" "534.6" "671.2" "504.0" "524.3" "474.9" "218.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "583939558635172856" "False" "High" "IsMasterProtein" "Q9Y4P1" "Cysteine protease ATG4B OS=Homo sapiens OX=9606 GN=ATG4B PE=1 SV=2" "0.000" "False" "23.672" "17" "5" "7" "5" "393" "44.3" "5.07" "29.03" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03416, Pf20166" "23192" "ENSG00000168397" "ATG4B" "B7WNK2; hsa:23192; Q53NU4; Q6ZUV8; Q8WYM9; Q96K07; Q96K96; Q96SZ1; Q9Y2F2; Q9Y4P1" "2q37 copy number variation syndrome" "Macroautophagy" "2" "0" "1.031" "1.066" "1.087" "1.042" "0.895" "1.147" "1.062" "1.011" "1.812" "139.0" "143.3" "148.1" "151.1" "144.9" "124.4" "159.3" "147.6" "140.4" "251.8" "" "" "" "" "" "" "" "" "" "" "124.9" "115.9" "134.0" "147.4" "119.5" "124.4" "119.3" "130.4" "125.7" "89.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970453667170528269" "False" "High" "IsMasterProtein" "P16083" "Ribosyldihydronicotinamide dehydrogenase [quinone] OS=Homo sapiens OX=9606 GN=NQO2 PE=1 SV=5" "0.000" "False" "23.669" "30" "5" "6" "5" "231" "25.9" "6.29" "26.82" "5" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf02525" "4835" "ENSG00000124588" "NQO2" "B2R492; P16083; Q5TD04" "Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "Phase I - Functionalization of compounds" "2" "0" "1.001" "0.985" "0.917" "1.004" "0.965" "0.968" "0.984" "0.959" "0.864" "405.3" "405.6" "399.0" "371.5" "406.8" "390.9" "392.4" "398.7" "388.4" "350.2" "" "" "" "" "" "" "" "" "" "" "364.4" "328.2" "360.9" "362.6" "335.7" "390.9" "293.9" "352.1" "347.6" "125.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4237649288618835376" "False" "High" "IsMasterProtein" "Q9NUP9" "Protein lin-7 homolog C OS=Homo sapiens OX=9606 GN=LIN7C PE=1 SV=1" "0.000" "False" "23.656" "37" "8" "12" "8" "197" "21.8" "8.43" "36.32" "8" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;other cell component" "cytoskeletal activity;other molecular function" "Pf00595, Pf02828" "55327" "ENSG00000148943" "LIN7C" "hsa:55327; Q9NUP9" "" "Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle" "3" "0" "0.931" "0.968" "0.905" "0.878" "0.996" "0.984" "1.000" "0.943" "0.928" "569.5" "530.5" "551.5" "515.3" "500.1" "567.2" "560.6" "569.4" "537.0" "528.4" "" "" "" "" "" "" "" "" "" "" "512.1" "429.3" "498.9" "503.0" "412.7" "567.2" "419.7" "503.0" "480.5" "188.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3276103228213200498" "False" "High" "IsMasterProtein" "P62308" "Small nuclear ribonucleoprotein G OS=Homo sapiens OX=9606 GN=SNRPG PE=1 SV=1" "0.000" "False" "23.646" "36" "4" "16" "4" "76" "8.5" "8.88" "47.09" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6637" "ENSG00000143977" "SNRPG" "D6W5G6; hsa:6637; P62308; Q15357; Q6IB86" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway; snRNP Assembly; RNA Polymerase II Transcription Termination; SARS-CoV-2 modulates host translation machinery; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "8" "0" "1.052" "1.058" "0.973" "1.098" "1.092" "1.015" "1.103" "1.153" "0.963" "1428.5" "1502.5" "1511.4" "1390.3" "1569.2" "1559.5" "1449.8" "1575.0" "1646.9" "1376.1" "" "" "" "" "" "" "" "" "" "" "1284.4" "1215.8" "1367.1" "1357.2" "1294.9" "1559.5" "1085.5" "1391.1" "1473.6" "491.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2957461368778197343" "False" "High" "IsMasterProtein" "Q96I51" "RCC1-like G exchanging factor-like protein OS=Homo sapiens OX=9606 GN=RCC1L PE=1 SV=3" "0.000" "False" "23.641" "16" "6" "7" "6" "464" "49.9" "8.29" "25.72" "6" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00415, Pf13540" "81554" "ENSG00000274523" "RCC1L" "D3DXK0; F5GX55; F5H6C7; hsa:81554; Q548B1; Q8IW88; Q8N572; Q96I51; Q9H0G7" "" "" "0" "0" "0.942" "0.885" "1.043" "1.022" "0.880" "0.986" "0.969" "0.984" "0.871" "250.4" "235.9" "221.6" "261.2" "256.1" "220.4" "247.0" "242.7" "246.3" "218.1" "" "" "" "" "" "" "" "" "" "" "225.2" "190.9" "200.4" "255.0" "211.3" "220.4" "184.9" "214.4" "220.4" "77.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-256514097134295092" "False" "High" "IsMasterProtein" "Q13546" "Receptor-interacting serine/threonine-protein kinase 1 OS=Homo sapiens OX=9606 GN=RIPK1 PE=1 SV=3" "0.000" "False" "23.630" "12" "6" "7" "6" "671" "75.9" "6.33" "24.30" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00531, Pf07714" "8737" "ENSG00000137275" "RIPK1" "A0AV89; B2RAG1; B4E3F9; hsa:8737; Q13180; Q13546; Q59H33" "Apoptosis modulation and signaling; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; TNF-alpha signaling pathway; Nanoparticle triggered regulated necrosis; Apoptosis; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; p38 MAPK signaling pathway; Cytosolic DNA-sensing pathway; Host-pathogen interaction of human coronaviruses - interferon induction; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Toll-like receptor signaling pathway" "IKK complex recruitment mediated by RIP1; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; Potential therapeutics for SARS; Ub-specific processing proteases; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TLR3-mediated TICAM1-dependent programmed cell death; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling; TRP channels; Microbial modulation of RIPK1-mediated regulated necrosis; SARS-CoV-1-mediated effects on programmed cell death; Defective RIPK1-mediated regulated necrosis" "35" "0" "0.920" "0.895" "0.959" "0.979" "0.888" "0.941" "0.894" "1.020" "1.356" "237.0" "217.9" "212.0" "227.3" "232.0" "210.5" "223.0" "212.0" "241.8" "321.4" "" "" "" "" "" "" "" "" "" "" "213.1" "176.4" "191.8" "221.9" "191.5" "210.5" "167.0" "187.2" "216.4" "114.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-404480449398085068" "False" "High" "IsMasterProtein" "P51809" "Vesicle-associated membrane protein 7 OS=Homo sapiens OX=9606 GN=VAMP7 PE=1 SV=3" "0.000" "False" "23.620" "30" "6" "9" "6" "220" "24.9" "8.60" "36.03" "6" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957, Pf13774" "6845" "ENSG00000124333; ENSG00000292366" "VAMP7" "hsa:6845; P51809; Q53GY7; Q7Z409; Q9H4A7" "" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Interleukin-12 signaling" "6" "0" "1.044" "0.978" "0.934" "1.030" "0.970" "1.037" "0.993" "0.994" "0.862" "1105.8" "1154.5" "1081.4" "1033.2" "1139.5" "1072.7" "1146.3" "1098.3" "1098.9" "952.8" "" "" "" "" "" "" "" "" "" "" "994.2" "934.2" "978.1" "1008.5" "940.4" "1072.7" "858.4" "970.1" "983.3" "340.1" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867390860608568122" "False" "High" "IsMasterProtein" "Q9BRJ2" "Large ribosomal subunit protein mL45 OS=Homo sapiens OX=9606 GN=MRPL45 PE=1 SV=2" "0.000" "False" "23.587" "23" "7" "9" "7" "306" "35.3" "9.03" "27.75" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf04280" "" "ENSG00000277936" "MRPL45" "A1L436; Q6ZMJ5; Q9BRJ2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.961" "0.846" "0.906" "0.959" "0.868" "0.878" "0.925" "0.932" "1.016" "459.6" "441.5" "389.0" "416.3" "440.9" "398.9" "403.7" "425.2" "428.1" "467.0" "" "" "" "" "" "" "" "" "" "" "413.2" "357.3" "351.9" "406.3" "363.8" "398.9" "302.3" "375.6" "383.1" "166.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179257016855703776" "False" "High" "IsMasterProtein" "Q53QV2" "Protein LBH OS=Homo sapiens OX=9606 GN=LBH PE=1 SV=1" "0.000" "False" "23.579" "55" "4" "6" "4" "105" "12.2" "4.41" "26.19" "4" "other biological processes" "nucleus;other cell component" "" "Pf15317" "81606" "ENSG00000213626" "LBH" "B2RBC2; hsa:81606; Q53QV2; Q9H0Q1" "" "" "0" "0" "0.943" "1.043" "0.953" "1.146" "1.250" "1.082" "1.150" "1.079" "0.888" "110.9" "104.6" "115.7" "105.7" "127.2" "138.6" "120.0" "127.5" "119.7" "98.5" "" "" "" "" "" "" "" "" "" "" "99.7" "84.6" "104.6" "103.1" "104.9" "138.6" "89.9" "112.6" "107.1" "35.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "916743004623214960" "False" "High" "IsMasterProtein" "P62266" "Small ribosomal subunit protein uS12 OS=Homo sapiens OX=9606 GN=RPS23 PE=1 SV=3" "0.000" "False" "23.579" "29" "5" "9" "5" "143" "15.8" "10.49" "36.48" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00164" "6228" "ENSG00000186468" "RPS23" "hsa:6228; P39028; P62266; Q6IB08" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Formation of the ternary complex, and subsequently, the 43S complex; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "20" "0" "1.122" "1.103" "1.110" "1.037" "1.099" "1.061" "1.034" "1.194" "1.123" "602.9" "676.3" "664.9" "669.4" "625.2" "662.3" "639.5" "623.3" "719.9" "677.2" "" "" "" "" "" "" "" "" "" "" "542.0" "547.2" "601.4" "653.5" "515.9" "662.3" "478.9" "550.6" "644.1" "241.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4412599355076663570" "False" "High" "IsMasterProtein" "Q8WV92" "MIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MITD1 PE=1 SV=1" "0.000" "False" "23.578" "26" "5" "8" "5" "249" "29.3" "8.00" "28.17" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04212, Pf16565" "129531" "ENSG00000158411" "MITD1" "hsa:129531; Q69YV0; Q8WV92" "TAR syndrome" "" "1" "0" "1.043" "0.990" "0.911" "1.008" "1.001" "1.048" "1.026" "0.980" "0.953" "332.8" "347.2" "329.4" "303.1" "335.4" "333.0" "348.9" "341.4" "326.1" "317.3" "" "" "" "" "" "" "" "" "" "" "299.2" "281.0" "298.0" "295.9" "276.7" "333.0" "261.2" "301.5" "291.8" "113.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7874915043186486884" "False" "High" "IsMasterProtein" "P20962" "Parathymosin OS=Homo sapiens OX=9606 GN=PTMS PE=1 SV=2" "0.000" "False" "23.569" "24" "4" "6" "4" "102" "11.5" "4.16" "25.26" "4" "DNA metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf03247" "5763" "ENSG00000159335" "PTMS" "hsa:5763; P20962" "IL-18 signaling pathway" "" "1" "0" "1.199" "0.988" "1.023" "0.969" "0.900" "0.951" "1.276" "0.836" "1.137" "561.9" "673.9" "555.1" "574.8" "544.7" "505.9" "534.5" "717.1" "469.8" "639.0" "" "" "" "" "" "" "" "" "" "" "505.2" "545.3" "502.1" "561.1" "449.5" "505.9" "400.2" "633.4" "420.4" "228.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-116543853618974429" "False" "High" "IsMasterProtein" "P20338" "Ras-related protein Rab-4A OS=Homo sapiens OX=9606 GN=RAB4A PE=1 SV=3" "0.000" "False" "23.551" "25" "5" "16" "2" "218" "24.4" "6.07" "45.38" "5" "transport;signal transduction;other biological processes" "non-structural extracellular;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5867" "ENSG00000168118" "RAB4A" "hsa:5867; P20338; Q5T7P7; Q9BQ44" "VEGFA-VEGFR2 signaling; Insulin signaling; Intracellular trafficking proteins involved in CMT neuropathy; 16p11.2 distal deletion syndrome" "RAB geranylgeranylation; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Synthesis of PIPs at the plasma membrane; TBC/RABGAPs; MET receptor recycling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9197774965471602114" "False" "High" "IsMasterProtein" "O60942" "mRNA-capping enzyme OS=Homo sapiens OX=9606 GN=RNGTT PE=1 SV=1" "0.000" "False" "23.547" "9" "5" "6" "5" "597" "68.5" "8.13" "24.23" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00782, Pf01331, Pf03919" "8732" "ENSG00000111880" "RNGTT" "E1P513; E1P514; hsa:8732; O43483; O60257; O60351; O60942; Q5TCW8; Q8WUM8" "mRNA processing; Ciliary landscape" "RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE" "5" "0" "1.087" "0.992" "0.971" "1.041" "1.119" "1.046" "1.058" "1.132" "1.184" "321.5" "349.6" "318.8" "312.3" "334.6" "359.8" "336.2" "340.2" "364.1" "380.5" "" "" "" "" "" "" "" "" "" "" "289.1" "282.8" "288.4" "304.8" "276.1" "359.8" "251.8" "300.5" "325.8" "135.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-749856808040687854" "False" "High" "IsMasterProtein" "Q8WTS6" "Histone-lysine N-methyltransferase SETD7 OS=Homo sapiens OX=9606 GN=SETD7 PE=1 SV=1" "0.000" "False" "23.545" "19" "6" "8" "6" "366" "40.7" "4.63" "29.80" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf02493" "80854" "ENSG00000145391" "SETD7" "B5WWL3; hsa:80854; Q0VAH3; Q4W5A9; Q8WTS6; Q9C0E6" "Histone modifications" "PKMTs methylate histone lysines" "2" "0" "0.915" "1.056" "1.022" "0.875" "1.027" "1.037" "0.939" "0.985" "1.411" "668.1" "611.5" "705.3" "682.6" "584.5" "685.9" "693.0" "627.0" "657.9" "943.0" "" "" "" "" "" "" "" "" "" "" "600.7" "494.8" "637.9" "666.3" "482.3" "685.9" "518.9" "553.8" "588.7" "336.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6182186368676627238" "False" "High" "IsMasterProtein" "Q13405" "Large ribosomal subunit protein mL49 OS=Homo sapiens OX=9606 GN=MRPL49 PE=1 SV=1" "0.000" "False" "23.538" "36" "6" "7" "6" "166" "19.2" "9.45" "27.66" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05046" "740" "ENSG00000149792" "MRPL49" "B2R4G6; hsa:740; Q13405" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.945" "0.982" "0.971" "0.988" "0.985" "0.949" "1.010" "1.002" "0.996" "814.1" "769.6" "799.8" "790.4" "804.5" "802.2" "772.7" "821.9" "815.8" "811.2" "" "" "" "" "" "" "" "" "" "" "731.9" "622.7" "723.4" "771.5" "663.9" "802.2" "578.6" "726.0" "730.0" "289.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2659436389650332532" "False" "High" "IsMasterProtein" "Q8TEQ0" "Sorting nexin-29 OS=Homo sapiens OX=9606 GN=SNX29 PE=1 SV=3" "0.000" "False" "23.492" "7" "4" "7" "1" "813" "91.2" "6.21" "30.78" "4" "" "" "other molecular function" "Pf00787, Pf02759" "92017" "ENSG00000048471" "SNX29" "B5MDW2; hsa:92017; Q8N2X2; Q8TEQ0; Q9HA26" "" "" "0" "0" "0.881" "0.798" "0.804" "0.656" "0.820" "1.085" "0.848" "0.929" "1.219" "27.6" "24.3" "22.0" "22.2" "18.1" "22.6" "29.9" "23.4" "25.6" "33.6" "" "" "" "" "" "" "" "" "" "" "24.8" "19.6" "19.9" "21.6" "14.9" "22.6" "22.4" "20.6" "22.9" "12.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-140378452823337742" "False" "High" "IsMasterProtein" "Q9HCN4" "GPN-loop GTPase 1 OS=Homo sapiens OX=9606 GN=GPN1 PE=1 SV=1" "0.000" "False" "23.483" "21" "6" "9" "6" "374" "41.7" "4.92" "30.22" "6" "" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf03029" "11321" "ENSG00000198522" "GPN1" "B4DQJ5; B4DQM4; B4DXU4; B5MBZ5; hsa:11321; O76004; Q9HCN4" "" "" "0" "0" "1.006" "1.042" "1.030" "1.045" "1.049" "0.952" "0.987" "1.111" "0.930" "438.8" "441.3" "457.1" "451.7" "458.7" "460.4" "417.6" "433.0" "487.7" "408.1" "" "" "" "" "" "" "" "" "" "" "394.5" "357.1" "413.5" "441.0" "378.5" "460.4" "312.7" "382.4" "436.4" "145.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7145553044462341407" "False" "High" "IsMasterProtein" "Q8NI36" "WD repeat-containing protein 36 OS=Homo sapiens OX=9606 GN=WDR36 PE=1 SV=1" "0.000" "False" "23.442" "9" "8" "8" "8" "951" "105.3" "7.53" "25.24" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04192, Pf12894" "134430" "" "WDR36" "A2RUS4; hsa:134430; Q68E02; Q8N1Q2; Q8NI36" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.981" "0.995" "0.899" "0.977" "1.219" "0.948" "0.905" "1.004" "0.914" "692.8" "679.7" "689.3" "622.5" "676.7" "844.4" "656.5" "626.7" "695.6" "633.3" "" "" "" "" "" "" "" "" "" "" "622.9" "550.0" "623.5" "607.7" "558.5" "844.4" "491.6" "553.6" "622.4" "226.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4353551603118957972" "False" "High" "IsMasterProtein" "P34949" "Mannose-6-phosphate isomerase OS=Homo sapiens OX=9606 GN=MPI PE=1 SV=2" "0.000" "False" "23.438" "17" "6" "6" "6" "423" "46.6" "5.95" "25.62" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf01238, Pf20511, Pf20512" "4351" "ENSG00000178802" "MPI" "A8K8K9; hsa:4351; P34949; Q96AB0" "N-glycan biosynthesis" "Synthesis of GDP-mannose; Defective MPI causes MPI-CDG" "3" "0" "0.875" "0.982" "0.917" "0.944" "0.970" "0.939" "0.847" "1.014" "0.864" "400.6" "350.3" "393.6" "367.5" "378.0" "388.7" "376.3" "339.1" "406.3" "346.2" "" "" "" "" "" "" "" "" "" "" "360.2" "283.5" "356.0" "358.7" "311.9" "388.7" "281.7" "299.5" "363.5" "123.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5613056624096108144" "False" "High" "IsMasterProtein" "Q7Z7E8" "Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens OX=9606 GN=UBE2Q1 PE=1 SV=1" "0.000" "False" "23.426" "19" "8" "10" "7" "422" "46.1" "5.10" "27.37" "8" "cell-cell signaling;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "55585" "ENSG00000160714" "UBE2Q1" "B4DF92; hsa:55585; Q29SN7; Q3B841; Q5I0X2; Q6IS04; Q6P7P2; Q7Z7E8; Q96MV4; Q9BVX5; Q9UGL6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "1" "1.048" "1.028" "0.913" "1.121" "0.998" "1.058" "0.994" "1.063" "1.156" "701.4" "734.9" "720.8" "640.7" "786.1" "700.1" "742.4" "696.9" "745.8" "810.9" "" "" "" "" "" "" "" "" "" "" "630.6" "594.7" "652.0" "625.4" "648.7" "700.1" "555.9" "615.6" "667.4" "289.5" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7674938862773320945" "False" "High" "IsMasterProtein" "A3KMH1" "von Willebrand factor A domain-containing protein 8 OS=Homo sapiens OX=9606 GN=VWA8 PE=1 SV=2" "0.000" "False" "23.399" "4" "8" "9" "8" "1905" "214.7" "7.40" "25.38" "8" "" "mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07728" "23078" "ENSG00000102763" "VWA8" "A3KMH1; hsa:23078; O60310; Q5JTP6; Q5VW08; Q7Z6I9; Q86YC9; Q8N3E4" "" "" "0" "0" "1.279" "1.146" "1.080" "1.151" "1.147" "1.131" "1.134" "1.171" "1.278" "204.9" "262.2" "234.8" "221.3" "235.9" "235.1" "231.8" "232.4" "239.9" "262.0" "" "" "" "" "" "" "" "" "" "" "184.3" "212.2" "212.4" "216.0" "194.7" "235.1" "173.6" "205.3" "214.7" "93.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076533743620825156" "False" "High" "IsMasterProtein" "Q02080" "Myocyte-specific enhancer factor 2B OS=Homo sapiens OX=9606 GN=MEF2B PE=1 SV=2" "0.000" "False" "23.391" "24" "7" "9" "7" "365" "38.6" "9.48" "32.83" "7" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00319" "100271849; 4207" "ENSG00000213999" "MEF2B" "A0AV80; B4DVH7; B7ZVY1; G5E9M1; hsa:100271849; hsa:4207; Q02080" "Energy metabolism; SRF and miRs in smooth muscle differentiation and proliferation; Cell differentiation - expanded index; Cell differentiation - index; Adipogenesis; Gastrin signaling pathway" "Myogenesis" "7" "0" "1.032" "0.985" "1.048" "1.036" "0.925" "1.068" "1.004" "0.970" "1.903" "641.8" "662.5" "632.1" "672.4" "665.0" "593.4" "685.3" "644.5" "622.6" "1221.7" "" "" "" "" "" "" "" "" "" "" "577.1" "536.1" "571.8" "656.4" "548.8" "593.4" "513.2" "569.2" "557.1" "436.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4910055014827061803" "False" "High" "IsMasterProtein" "Q14653" "Interferon regulatory factor 3 OS=Homo sapiens OX=9606 GN=IRF3 PE=1 SV=1" "0.000" "False" "23.385" "16" "5" "9" "5" "427" "47.2" "5.34" "26.50" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3661" "ENSG00000126456" "IRF3" "A8K7L2; B2RAZ3; hsa:3661; Q14653; Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6" "Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Fibrin complement receptor 3 signaling pathway; White fat cell differentiation; Ebola virus infection in host; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; STING pathway in Kawasaki-like disease and COVID-19; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; Lung pathology of COVID-19; Urotensin-II-mediated signaling pathway; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; Toll-like receptor signaling pathway" "SARS-CoV-1 activates/modulates innate immune responses; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Interferon gamma signaling; Interferon alpha/beta signaling; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation; Evasion by RSV of host interferon responses; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN; LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production; IRF3 mediated activation of type 1 IFN" "38" "0" "1.030" "1.046" "0.833" "0.987" "0.972" "1.052" "0.924" "0.967" "0.807" "466.6" "480.7" "488.0" "388.8" "460.6" "453.4" "490.7" "431.1" "451.0" "376.6" "" "" "" "" "" "" "" "" "" "" "419.5" "388.9" "441.5" "379.5" "380.1" "453.4" "367.4" "380.8" "403.5" "134.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8164709769345228762" "False" "High" "IsMasterProtein" "Q9H4Z3" "mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase OS=Homo sapiens OX=9606 GN=PCIF1 PE=1 SV=1" "0.000" "False" "23.384" "13" "8" "9" "8" "704" "80.6" "7.42" "25.35" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf12237" "63935" "ENSG00000100982" "PCIF1" "E1P5P1; hsa:63935; Q54AB9; Q9H4Z3; Q9NT85" "" "" "0" "0" "1.017" "1.024" "0.988" "1.005" "1.067" "1.046" "0.971" "1.038" "0.809" "317.5" "322.9" "325.1" "313.6" "319.0" "338.6" "332.1" "308.4" "329.7" "256.9" "" "" "" "" "" "" "" "" "" "" "285.5" "261.2" "294.0" "306.1" "263.2" "338.6" "248.7" "272.4" "295.0" "91.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559430331434459476" "False" "High" "IsMasterProtein" "O95630" "STAM-binding protein OS=Homo sapiens OX=9606 GN=STAMBP PE=1 SV=1" "0.000" "False" "23.379" "14" "7" "9" "7" "424" "48.0" "6.29" "29.57" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "10617" "ENSG00000124356" "STAMBP" "B5M0B6; D6W5H7; hsa:10617; O95630; Q3MJE7" "EGF/EGFR signaling pathway" "Metalloprotease DUBs" "2" "0" "1.015" "1.126" "1.091" "1.067" "1.055" "1.100" "1.013" "1.099" "2.124" "692.5" "702.6" "779.9" "755.4" "739.2" "730.3" "761.4" "701.6" "761.3" "1470.7" "" "" "" "" "" "" "" "" "" "" "622.6" "568.6" "705.5" "737.4" "610.0" "730.3" "570.1" "619.7" "681.2" "525.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8654405548002230634" "False" "High" "IsMasterProtein" "Q49B96" "Cytochrome c oxidase assembly protein COX19 OS=Homo sapiens OX=9606 GN=COX19 PE=1 SV=1" "0.000" "False" "23.301" "44" "4" "11" "4" "90" "10.4" "8.72" "31.40" "4" "cell organization and biogenesis;other biological processes" "cytosol;mitochondrion" "" "Pf06747" "90639" "ENSG00000240230" "COX19" "A4FTX0; hsa:90639; Q49B96" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1; Mitochondrial protein import" "5" "0" "0.947" "0.945" "0.962" "1.027" "0.955" "0.981" "1.061" "0.965" "0.864" "1185.4" "1122.8" "1120.4" "1140.4" "1217.9" "1132.4" "1162.3" "1257.6" "1143.9" "1023.7" "" "" "" "" "" "" "" "" "" "" "1065.7" "908.6" "1013.5" "1113.2" "1005.0" "1132.4" "870.3" "1110.8" "1023.6" "365.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-220085271204376127" "False" "High" "IsMasterProtein" "O95983" "Methyl-CpG-binding domain protein 3 OS=Homo sapiens OX=9606 GN=MBD3 PE=1 SV=1" "0.000" "False" "23.297" "35" "8" "8" "7" "291" "32.8" "5.34" "29.05" "8" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf14048, Pf16564" "53615" "ENSG00000071655" "MBD3" "A8K4B7; D6W5Z2; hsa:53615; O95983; Q6PIL9; Q6PJZ9; Q86XF4" "Effect of progerin on genes involved in progeria" "Potential therapeutics for SARS; Regulation of PTEN gene transcription; HDACs deacetylate histones; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Regulation of TP53 Activity through Acetylation" "7" "0" "1.043" "1.114" "0.940" "1.039" "1.165" "1.002" "1.080" "0.946" "1.941" "681.6" "710.9" "759.5" "640.7" "708.1" "794.2" "682.7" "736.0" "644.5" "1323.4" "" "" "" "" "" "" "" "" "" "" "612.9" "575.2" "687.0" "625.4" "584.4" "794.2" "511.2" "650.1" "576.7" "472.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2566135857611723126" "False" "High" "IsMasterProtein" "P23743" "Diacylglycerol kinase alpha OS=Homo sapiens OX=9606 GN=DGKA PE=1 SV=3" "0.000" "False" "23.274" "12" "8" "9" "8" "735" "82.6" "6.73" "30.39" "8" "other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00130, Pf00609, Pf00781, Pf14513" "1606" "ENSG00000065357" "DGKA" "hsa:1606; O75481; O75482; O75483; O95217; P23743; Q3ZE25; Q8IZ56; Q8N5Q2" "Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "2" "0" "0.989" "0.953" "1.014" "0.936" "0.972" "1.043" "0.940" "0.948" "1.669" "649.9" "642.6" "619.6" "658.8" "608.2" "631.4" "677.5" "610.7" "616.3" "1084.9" "" "" "" "" "" "" "" "" "" "" "584.3" "520.0" "560.4" "643.1" "501.9" "631.4" "507.3" "539.4" "551.5" "387.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6240337966017765757" "False" "High" "IsMasterProtein" "Q0VDG4" "Secernin-3 OS=Homo sapiens OX=9606 GN=SCRN3 PE=1 SV=1" "0.000" "False" "23.266" "21" "7" "8" "7" "424" "48.5" "5.55" "24.54" "7" "protein metabolism" "" "other molecular function" "Pf03577" "79634" "ENSG00000144306" "SCRN3" "B4DI11; C9JPC1; D3DPE0; hsa:79634; Q0VDG4; Q7L1C5; Q9H5R5" "" "" "0" "0" "0.962" "1.032" "1.007" "1.071" "1.029" "1.032" "1.000" "1.035" "0.919" "435.8" "419.1" "450.0" "439.1" "466.7" "448.5" "449.8" "435.6" "450.9" "400.6" "" "" "" "" "" "" "" "" "" "" "391.8" "339.1" "407.0" "428.6" "385.1" "448.5" "336.8" "384.8" "403.4" "143.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657914547001490376" "False" "High" "IsMasterProtein" "P53778" "Mitogen-activated protein kinase 12 OS=Homo sapiens OX=9606 GN=MAPK12 PE=1 SV=3" "0.000" "False" "23.266" "21" "7" "8" "6" "367" "41.9" "6.39" "25.09" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6300" "ENSG00000188130" "MAPK12" "hsa:6300; P53778; Q14260; Q6IC53; Q99588; Q99672" "Integrin-mediated cell adhesion; Parkinson's disease pathway; S1P receptor signal transduction; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; MAPK signaling pathway; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Thermogenesis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Regulatory circuits of the STAT3 signaling pathway; Hepatitis B infection; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Osteoblast differentiation and related diseases; Insulin signaling; Host-pathogen interaction of human coronaviruses - apoptosis; Host-pathogen interaction of human coronaviruses - MAPK signaling; Toll-like receptor signaling pathway" "VEGFA-VEGFR2 Pathway; Myogenesis; NOD1/2 Signaling Pathway; p38MAPK events; DSCAM interactions; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Negative regulation of MAPK pathway" "30" "0" "1.131" "1.162" "0.967" "1.204" "1.141" "1.250" "1.018" "1.056" "0.959" "334.7" "378.6" "389.1" "323.7" "402.9" "382.0" "418.4" "340.9" "353.4" "321.0" "" "" "" "" "" "" "" "" "" "" "300.9" "306.3" "351.9" "316.0" "332.5" "382.0" "313.3" "301.1" "316.2" "114.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224070834007844842" "False" "High" "IsMasterProtein" "Q9BW91" "ADP-ribose pyrophosphatase, mitochondrial OS=Homo sapiens OX=9606 GN=NUDT9 PE=1 SV=1" "0.000" "False" "23.265" "19" "8" "12" "8" "350" "39.1" "8.22" "33.24" "8" "other metabolic processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00293" "53343" "ENSG00000170502" "NUDT9" "hsa:53343; Q8NBN1; Q8NCB9; Q8NG25; Q9BW91" "" "" "0" "0" "0.977" "0.994" "0.957" "1.057" "1.042" "1.019" "0.978" "1.056" "0.961" "1441.8" "1408.0" "1432.9" "1380.0" "1524.1" "1502.0" "1469.7" "1409.4" "1522.2" "1385.1" "" "" "" "" "" "" "" "" "" "" "1296.3" "1139.3" "1296.1" "1347.0" "1257.7" "1502.0" "1100.5" "1244.9" "1362.0" "494.5" "9" "9" "9" "9" "9" "9" "9" "9" "9" "9" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3452513591771994158" "False" "High" "IsMasterProtein" "Q6ICG6" "Uncharacterized protein KIAA0930 OS=Homo sapiens OX=9606 GN=KIAA0930 PE=1 SV=1" "0.000" "False" "23.261" "17" "6" "6" "6" "404" "45.8" "7.94" "24.73" "6" "" "" "" "Pf09741" "23313" "ENSG00000100364" "KIAA0930" "B0QY17; B0QY19; B3KT48; hsa:23313; Q6ICG6; Q6ZVE5; Q7Z6K9; Q8IZ76; Q9Y2E2" "" "" "0" "0" "1.058" "1.002" "0.914" "1.034" "1.060" "1.045" "1.021" "1.009" "1.003" "434.7" "459.8" "435.7" "397.2" "449.5" "461.0" "454.2" "443.9" "438.4" "436.2" "" "" "" "" "" "" "" "" "" "" "390.9" "372.1" "394.1" "387.7" "370.9" "461.0" "340.1" "392.1" "392.3" "155.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2054594351010378030" "False" "High" "IsMasterProtein" "Q9H977" "WD repeat-containing protein 54 OS=Homo sapiens OX=9606 GN=WDR54 PE=1 SV=1" "0.000" "False" "23.253" "27" "5" "6" "5" "334" "35.9" "6.20" "24.67" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf21031" "84058" "ENSG00000005448" "WDR54" "B9A049; D6W5I3; hsa:84058; Q53H85; Q86V45; Q9H977" "" "" "0" "0" "1.141" "1.193" "1.049" "1.208" "1.135" "1.314" "1.076" "1.159" "0.928" "146.9" "167.6" "175.3" "154.1" "177.4" "166.8" "193.0" "158.0" "170.3" "136.3" "" "" "" "" "" "" "" "" "" "" "132.1" "135.6" "158.6" "150.4" "146.4" "166.8" "144.5" "139.6" "152.4" "48.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "718795190937465911" "False" "High" "IsMasterProtein" "Q9Y6V7" "Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens OX=9606 GN=DDX49 PE=1 SV=1" "0.000" "False" "23.238" "15" "7" "8" "7" "483" "54.2" "9.06" "27.36" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "54555" "ENSG00000105671" "DDX49" "E7ENA0; hsa:54555; Q53FJ1; Q9BVQ8; Q9Y6V7" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.985" "0.824" "0.920" "0.945" "0.815" "0.990" "0.926" "0.823" "0.925" "792.7" "780.5" "653.1" "729.2" "748.9" "645.8" "785.0" "733.9" "652.4" "733.0" "" "" "" "" "" "" "" "" "" "" "712.7" "631.6" "590.8" "711.8" "618.0" "645.8" "587.8" "648.3" "583.8" "261.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4830311805247258078" "False" "High" "IsMasterProtein" "Q9NPD3" "Exosome complex component RRP41 OS=Homo sapiens OX=9606 GN=EXOSC4 PE=1 SV=3" "0.000" "False" "23.215" "28" "7" "10" "7" "245" "26.4" "6.52" "34.41" "7" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01138, Pf03725" "54512" "ENSG00000178896" "EXOSC4" "hsa:54512; Q9NPD3" "Ciliary landscape" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "7" "0" "1.087" "1.067" "1.029" "1.085" "1.060" "1.090" "1.003" "1.123" "0.863" "416.7" "452.9" "444.4" "428.8" "451.9" "441.8" "454.2" "418.1" "467.8" "359.6" "" "" "" "" "" "" "" "" "" "" "374.6" "366.4" "402.0" "418.6" "373.0" "441.8" "340.1" "369.3" "418.6" "128.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1864840127282000894" "False" "High" "IsMasterProtein" "Q9Y2I1" "Nischarin OS=Homo sapiens OX=9606 GN=NISCH PE=1 SV=3" "0.000" "False" "23.195" "5" "8" "8" "8" "1504" "166.5" "5.14" "25.09" "8" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00787" "11188" "ENSG00000010322" "NISCH" "C9J245; hsa:11188; Q6PGP3; Q6PIB4; Q7L8M3; Q7Z2X6; Q9UES6; Q9UEU4; Q9UFW3; Q9Y2I1" "" "RAC1 GTPase cycle; RND2 GTPase cycle; RND3 GTPase cycle" "3" "0" "1.040" "1.014" "0.898" "1.112" "1.123" "1.128" "0.956" "1.017" "1.069" "335.2" "348.7" "339.7" "300.9" "372.6" "376.4" "378.0" "320.6" "340.7" "358.5" "" "" "" "" "" "" "" "" "" "" "301.4" "282.1" "307.3" "293.7" "307.5" "376.4" "283.1" "283.2" "304.9" "128.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6920554993800994285" "False" "High" "IsMasterProtein" "Q02880" "DNA topoisomerase 2-beta OS=Homo sapiens OX=9606 GN=TOP2B PE=1 SV=3" "0.000" "False" "23.178" "5" "6" "8" "5" "1626" "183.2" "8.00" "24.74" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7155" "ENSG00000077097" "TOP2B" "hsa:7155; Q02880; Q13600; Q9UMG8; Q9UQP8" "" "SUMOylation of DNA replication proteins" "1" "0" "1.009" "0.898" "0.949" "0.899" "0.903" "0.898" "0.812" "0.840" "0.727" "178.7" "180.3" "160.4" "169.5" "160.6" "161.3" "160.5" "145.1" "150.1" "129.9" "" "" "" "" "" "" "" "" "" "" "160.6" "145.9" "145.1" "165.5" "132.5" "161.3" "120.2" "128.2" "134.3" "46.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657288411045177937" "False" "High" "IsMasterProtein" "O95429" "BAG family molecular chaperone regulator 4 OS=Homo sapiens OX=9606 GN=BAG4 PE=1 SV=1" "0.000" "False" "23.167" "13" "5" "10" "4" "457" "49.6" "5.12" "32.82" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02179" "9530" "ENSG00000156735" "BAG4" "B4E217; hsa:9530; O95429; O95818" "Oxidative damage response" "Regulation of HSF1-mediated heat shock response; Signaling by FGFR1 in disease; Signaling by plasma membrane FGFR1 fusions; TNF signaling" "5" "0" "0.994" "0.966" "0.990" "0.969" "1.006" "0.976" "1.007" "1.079" "0.916" "352.6" "350.4" "340.7" "349.2" "341.6" "354.7" "344.2" "355.1" "380.6" "323.1" "" "" "" "" "" "" "" "" "" "" "317.0" "283.5" "308.2" "340.9" "281.9" "354.7" "257.7" "313.6" "340.6" "115.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4597879666501405539" "False" "High" "IsMasterProtein" "Q9NX08" "COMM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=COMMD8 PE=1 SV=1" "0.000" "False" "23.167" "22" "3" "6" "3" "183" "21.1" "5.43" "24.13" "3" "" "cytosol;nucleus" "" "Pf07258" "54951" "ENSG00000169019" "COMMD8" "hsa:54951; Q8WUR4; Q9HC15; Q9NX08" "" "Neddylation" "1" "0" "0.985" "1.040" "1.048" "1.067" "0.945" "1.056" "1.005" "1.027" "1.153" "456.0" "449.2" "474.2" "478.0" "486.4" "431.0" "481.4" "458.2" "468.3" "525.7" "" "" "" "" "" "" "" "" "" "" "410.0" "363.5" "428.9" "466.6" "401.4" "431.0" "360.4" "404.7" "419.0" "187.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3530209516211162637" "False" "High" "IsMasterProtein" "Q5JRA6" "Transport and Golgi organization protein 1 homolog OS=Homo sapiens OX=9606 GN=MIA3 PE=1 SV=1" "0.000" "False" "23.141" "5" "8" "8" "8" "1907" "213.6" "4.84" "25.74" "8" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07653" "375056" "ENSG00000154305" "MIA3" "A8K2S0; A8MT05; A8MT13; B7Z430; hsa:375056; Q14083; Q3S4X3; Q5JRA5; Q5JRA6; Q5JRB0; Q5JRB1; Q5JRB2; Q6UVY8; Q86Y60; Q8N8M5; Q92580" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Cargo concentration in the ER; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "0.958" "1.039" "1.077" "1.115" "1.069" "1.133" "1.107" "1.044" "0.855" "558.5" "535.2" "580.0" "601.5" "622.5" "596.8" "632.7" "618.5" "582.8" "477.3" "" "" "" "" "" "" "" "" "" "" "502.1" "433.1" "524.6" "587.2" "513.7" "596.8" "473.7" "546.3" "521.5" "170.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1450740357169926082" "False" "High" "IsMasterProtein" "P40121" "Macrophage-capping protein OS=Homo sapiens OX=9606 GN=CAPG PE=1 SV=2" "0.000" "False" "23.130" "16" "5" "6" "5" "348" "38.5" "6.19" "24.20" "5" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "822" "ENSG00000042493" "CAPG" "B8ZZS7; D6W5K8; hsa:822; P40121; Q53SA7" "TYROBP causal network in microglia" "" "1" "0" "0.930" "0.931" "0.951" "0.964" "0.946" "0.958" "0.959" "0.937" "0.874" "538.3" "500.6" "501.0" "512.0" "518.8" "509.0" "515.6" "516.2" "504.2" "470.5" "" "" "" "" "" "" "" "" "" "" "484.0" "405.0" "453.2" "499.8" "428.1" "509.0" "386.1" "455.9" "451.1" "168.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945964816553277045" "False" "High" "IsMasterProtein" "Q9Y2X0" "Mediator of RNA polymerase II transcription subunit 16 OS=Homo sapiens OX=9606 GN=MED16 PE=1 SV=2" "0.000" "False" "23.124" "8" "6" "7" "6" "877" "96.7" "7.37" "26.62" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00400, Pf11635, Pf20718, Pf20719" "10025" "ENSG00000175221" "MED16" "hsa:10025; Q6PJT2; Q96AD4; Q96I35; Q9Y2X0; Q9Y652" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.996" "0.985" "0.967" "0.995" "1.026" "0.967" "0.945" "1.028" "1.209" "528.8" "526.6" "520.7" "511.5" "526.0" "542.7" "511.2" "499.5" "543.7" "639.1" "" "" "" "" "" "" "" "" "" "" "475.4" "426.1" "471.0" "499.3" "434.1" "542.7" "382.8" "441.2" "486.5" "228.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-692133851352470930" "False" "High" "IsMasterProtein" "Q14376" "UDP-glucose 4-epimerase OS=Homo sapiens OX=9606 GN=GALE PE=1 SV=2" "0.000" "False" "23.119" "25" "8" "9" "8" "348" "38.3" "6.73" "31.95" "8" "other metabolic processes" "cytosol" "other molecular function" "Pf16363" "2582" "ENSG00000117308" "GALE" "A0A024RAH5; B3KQ39; hsa:2582; Q14376; Q38G75; Q86W41; Q9BVE3; Q9UJB4" "Disorders of galactose metabolism ; UDP-derived sugars synthesis in fibroblasts" "Galactose catabolism; Defective GALE causes EDG" "4" "0" "1.004" "1.087" "1.002" "1.034" "1.058" "1.037" "1.061" "1.036" "1.083" "1019.1" "1023.0" "1107.3" "1021.5" "1053.7" "1078.2" "1057.2" "1081.2" "1056.1" "1104.0" "" "" "" "" "" "" "" "" "" "" "916.3" "827.8" "1001.6" "997.2" "869.5" "1078.2" "791.6" "955.0" "945.0" "394.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3678335116251458371" "False" "High" "IsMasterProtein" "P22670" "MHC class II regulatory factor RFX1 OS=Homo sapiens OX=9606 GN=RFX1 PE=1 SV=2" "0.000" "False" "23.083" "7" "5" "7" "5" "979" "104.7" "6.29" "28.11" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257, Pf04589" "5989" "ENSG00000132005; ENSG00000288283" "RFX1" "hsa:5989; P22670" "Alstrom syndrome" "" "1" "0" "0.996" "0.899" "0.918" "1.040" "0.939" "0.988" "1.004" "0.920" "0.886" "648.5" "645.6" "583.1" "595.3" "674.5" "609.2" "640.4" "651.2" "596.5" "574.6" "" "" "" "" "" "" "" "" "" "" "583.0" "522.4" "527.4" "581.1" "556.6" "609.2" "479.5" "575.2" "533.8" "205.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8306155883597695001" "False" "High" "IsMasterProtein" "Q9NTM9" "Copper homeostasis protein cutC homolog OS=Homo sapiens OX=9606 GN=CUTC PE=1 SV=1" "0.000" "False" "23.076" "30" "5" "8" "5" "273" "29.3" "8.18" "35.92" "5" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03932" "51076" "ENSG00000119929" "CUTC" "hsa:51076; Q5TCZ8; Q9NTM9; Q9Y321" "" "Ion transport by P-type ATPases" "1" "0" "1.046" "1.050" "1.046" "1.167" "1.018" "1.088" "1.015" "1.067" "1.167" "581.1" "607.9" "610.1" "608.0" "678.1" "591.7" "632.0" "589.7" "620.2" "678.0" "" "" "" "" "" "" "" "" "" "" "522.4" "491.9" "551.9" "593.5" "559.5" "591.7" "473.2" "520.9" "555.0" "242.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117675378851989584" "False" "High" "IsMasterProtein" "P56270" "Myc-associated zinc finger protein OS=Homo sapiens OX=9606 GN=MAZ PE=1 SV=1" "0.000" "False" "23.067" "13" "6" "10" "4" "477" "48.6" "8.95" "24.78" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "4150" "ENSG00000103495" "MAZ" "A8QJL9; C6G496; G5E927; H3BQD6; hsa:4150; P56270; Q15703; Q8NFN7; Q99443" "16p11.2 proximal deletion syndrome; Sudden infant death syndrome (SIDS) susceptibility pathways" "" "2" "2" "0.927" "0.952" "1.067" "1.034" "1.106" "0.934" "1.129" "1.063" "0.897" "397.6" "368.6" "378.6" "424.1" "411.0" "439.7" "371.3" "449.0" "422.7" "356.6" "" "" "" "" "" "" "" "" "" "" "357.5" "298.2" "342.5" "413.9" "339.2" "439.7" "278.0" "396.5" "378.3" "127.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3621833610637206208" "False" "High" "IsMasterProtein" "Q92623" "Tetratricopeptide repeat protein 9A OS=Homo sapiens OX=9606 GN=TTC9 PE=1 SV=3" "0.000" "False" "23.065" "31" "7" "9" "7" "222" "24.4" "8.98" "29.25" "7" "developmental processes" "" "" "" "23508" "ENSG00000133985" "TTC9" "hsa:23508; Q86WT2; Q92623" "Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)" "" "1" "0" "1.071" "0.905" "0.975" "1.059" "1.048" "1.038" "1.190" "1.041" "0.806" "467.9" "501.1" "423.4" "456.0" "495.6" "490.3" "485.5" "556.6" "487.1" "377.4" "" "" "" "" "" "" "" "" "" "" "420.7" "405.5" "382.9" "445.1" "409.0" "490.3" "363.5" "491.6" "435.8" "134.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4658645955564383119" "False" "High" "IsMasterProtein" "Q86Y82" "Syntaxin-12 OS=Homo sapiens OX=9606 GN=STX12 PE=1 SV=1" "0.000" "False" "23.026" "20" "5" "7" "5" "276" "31.6" "5.59" "28.17" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf14523" "23673" "ENSG00000117758" "STX12" "B1AJQ7; hsa:23673; O95564; Q86Y82" "" "" "0" "0" "0.910" "0.898" "0.984" "0.924" "0.964" "1.023" "0.975" "0.910" "0.768" "615.7" "560.5" "552.8" "605.9" "568.8" "593.4" "629.7" "600.4" "560.3" "472.6" "" "" "" "" "" "" "" "" "" "" "553.6" "453.6" "500.0" "591.4" "469.4" "593.4" "471.5" "530.4" "501.3" "168.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3150532128508731386" "False" "High" "IsMasterProtein" "O75554" "WW domain-binding protein 4 OS=Homo sapiens OX=9606 GN=WBP4 PE=1 SV=1" "0.000" "False" "23.023" "18" "5" "7" "5" "376" "42.5" "5.57" "30.26" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00397, Pf06220" "11193" "ENSG00000120688" "WBP4" "B7Z4M2; hsa:11193; O75554; Q32P29" "" "mRNA Splicing - Major Pathway" "1" "0" "0.985" "1.038" "0.982" "1.041" "1.104" "1.046" "1.009" "1.024" "0.889" "554.3" "546.2" "575.3" "544.4" "577.2" "612.3" "579.9" "559.5" "567.5" "492.7" "" "" "" "" "" "" "" "" "" "" "498.4" "441.9" "520.4" "531.5" "476.3" "612.3" "434.2" "494.2" "507.8" "175.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8715917564772373095" "False" "High" "IsMasterProtein" "Q9C0B7" "Transport and Golgi organization protein 6 homolog OS=Homo sapiens OX=9606 GN=TANGO6 PE=1 SV=2" "0.000" "False" "23.023" "7" "7" "7" "7" "1094" "120.7" "6.11" "26.05" "7" "transport" "other membranes" "" "Pf10304, Pf10363" "79613" "ENSG00000103047" "TANGO6" "hsa:79613; Q569F9; Q9C0B7; Q9H9K1" "" "" "0" "0" "1.006" "0.976" "0.870" "0.983" "0.891" "0.936" "0.918" "0.890" "1.111" "692.1" "696.2" "675.5" "601.8" "680.5" "616.6" "647.9" "635.3" "615.8" "768.9" "" "" "" "" "" "" "" "" "" "" "622.3" "563.4" "611.0" "587.5" "561.5" "616.6" "485.1" "561.1" "551.0" "274.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4154792399073788951" "False" "High" "IsMasterProtein" "Q13541" "Eukaryotic translation initiation factor 4E-binding protein 1 OS=Homo sapiens OX=9606 GN=EIF4EBP1 PE=1 SV=3" "0.000" "False" "23.020" "32" "2" "10" "2" "118" "12.6" "5.48" "34.86" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05456" "1978" "ENSG00000187840" "EIF4EBP1" "B2R502; D3DSW8; hsa:1978; Q13541; Q6IBN3" "Translation factors; AMP-activated protein kinase signaling; Target of rapamycin signaling; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; RAC1/PAK1/p38/MMP2 pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Head and neck squamous cell carcinoma; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Hypertrophy model; Acute myeloid leukemia; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling; Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S" "32" "0" "0.994" "0.908" "0.882" "0.889" "0.927" "0.957" "0.847" "0.876" "0.925" "351.0" "348.8" "318.9" "309.7" "312.1" "325.4" "335.9" "297.3" "307.4" "324.8" "" "" "" "" "" "" "" "" "" "" "315.6" "282.2" "288.4" "302.3" "257.6" "325.4" "251.5" "262.6" "275.0" "115.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6795582567929622559" "False" "High" "IsMasterProtein" "P61916" "NPC intracellular cholesterol transporter 2 OS=Homo sapiens OX=9606 GN=NPC2 PE=1 SV=1" "0.000" "False" "23.020" "40" "6" "7" "6" "151" "16.6" "7.65" "26.63" "6" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf02221" "10577" "ENSG00000119655" "NPC2" "B4DQV7; P61916; Q15668; Q29413" "TYROBP causal network in microglia; Degradation pathway of sphingolipids, including diseases; Ebola virus infection in host; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Neutrophil degranulation; LDL clearance" "7" "0" "0.841" "1.128" "0.914" "0.969" "1.145" "0.960" "0.998" "1.197" "0.763" "706.6" "593.9" "796.8" "645.7" "684.7" "808.9" "678.4" "705.2" "846.0" "539.4" "" "" "" "" "" "" "" "" "" "" "635.3" "480.6" "720.7" "630.3" "565.0" "808.9" "508.0" "622.9" "757.0" "192.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6665492664209257681" "False" "High" "IsMasterProtein" "Q6P1Q9" "tRNA N(3)-methylcytidine methyltransferase METTL2B OS=Homo sapiens OX=9606 GN=METTL2B PE=1 SV=3" "0.000" "False" "22.998" "16" "5" "10" "5" "378" "43.4" "5.86" "31.23" "5" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf08242" "55798" "ENSG00000165055" "METTL2B" "B4DZ68; hsa:55798; Q0IJ54; Q3B7J1; Q6P1Q9" "" "" "0" "0" "0.928" "1.013" "0.992" "0.916" "0.978" "0.995" "0.886" "1.041" "1.357" "704.9" "654.1" "713.7" "699.1" "645.4" "689.4" "701.3" "624.8" "734.1" "956.7" "" "" "" "" "" "" "" "" "" "" "633.8" "529.3" "645.6" "682.4" "532.6" "689.4" "525.1" "551.9" "656.9" "341.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654613729152941586" "False" "High" "IsMasterProtein" "P23786" "Carnitine O-palmitoyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=CPT2 PE=1 SV=2" "0.000" "False" "22.975" "12" "8" "9" "8" "658" "73.7" "8.18" "23.98" "8" "other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00755" "1376" "ENSG00000157184" "CPT2" "B2R6S0; hsa:1376; P23786; Q5SW68; Q9BQ26" "Fatty acid beta-oxidation; PPAR-alpha pathway; Nuclear receptors meta-pathway; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Thermogenesis; Mitochondrial fatty acid oxidation disorders" "PPARA activates gene expression; Carnitine metabolism" "9" "0" "1.029" "0.995" "0.925" "0.989" "0.960" "0.947" "0.996" "1.004" "0.996" "633.7" "652.1" "630.7" "586.0" "626.9" "608.1" "599.9" "631.0" "636.0" "631.2" "" "" "" "" "" "" "" "" "" "" "569.8" "527.7" "570.4" "572.0" "517.3" "608.1" "449.2" "557.4" "569.1" "225.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5140965250815444674" "False" "High" "IsMasterProtein" "Q9ULJ6" "Zinc finger MIZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZMIZ1 PE=1 SV=3" "0.000" "False" "22.972" "8" "7" "8" "3" "1067" "115.4" "7.46" "28.81" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02891, Pf18028" "57178" "ENSG00000108175" "ZMIZ1" "hsa:57178; Q5JSH9; Q7Z7E6; Q9ULJ6" "Androgen receptor signaling pathway" "" "1" "4" "1.060" "0.990" "0.970" "1.163" "0.987" "1.212" "0.988" "0.936" "0.832" "712.9" "755.3" "706.0" "691.5" "829.0" "703.7" "864.0" "704.4" "667.0" "592.9" "" "" "" "" "" "" "" "" "" "" "640.9" "611.2" "638.6" "675.0" "684.1" "703.7" "646.9" "622.1" "596.8" "211.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3331965257696457103" "False" "High" "IsMasterProtein" "Q9H467" "CUE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CUEDC2 PE=1 SV=1" "0.000" "False" "22.963" "28" "6" "7" "6" "287" "32.0" "4.81" "23.97" "6" "other biological processes" "other membranes;cytosol;nucleus" "other molecular function" "Pf02845" "79004" "ENSG00000107874" "CUEDC2" "D3DR88; hsa:79004; Q9BWG8; Q9H467" "" "" "0" "0" "0.891" "1.005" "0.868" "0.970" "1.014" "0.914" "0.966" "1.068" "0.832" "743.2" "662.4" "746.7" "645.0" "721.1" "753.4" "679.1" "718.0" "793.5" "618.4" "" "" "" "" "" "" "" "" "" "" "668.2" "536.0" "675.4" "629.7" "595.0" "753.4" "508.5" "634.2" "710.0" "220.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7625852785660981987" "False" "High" "IsMasterProtein" "Q15126" "Phosphomevalonate kinase OS=Homo sapiens OX=9606 GN=PMVK PE=1 SV=3" "0.000" "False" "22.961" "28" "5" "7" "5" "192" "22.0" "5.73" "25.13" "5" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "kinase activity;other molecular function" "Pf04275" "10654" "ENSG00000163344" "PMVK" "Q15126; Q5TZW9" "Cholesterol biosynthesis pathway; Mevalonate pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "1.110" "1.144" "0.986" "1.129" "1.116" "1.105" "1.164" "1.102" "3.075" "539.8" "599.1" "617.6" "532.1" "609.5" "602.4" "596.5" "628.1" "595.0" "1659.9" "" "" "" "" "" "" "" "" "" "" "485.3" "484.7" "558.6" "519.4" "503.0" "602.4" "446.7" "554.8" "532.4" "592.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4461868117343589472" "False" "High" "IsMasterProtein" "Q66K14" "TBC1 domain family member 9B OS=Homo sapiens OX=9606 GN=TBC1D9B PE=1 SV=3" "0.000" "False" "22.955" "7" "8" "8" "8" "1250" "140.4" "5.25" "25.19" "8" "" "other membranes" "enzyme regulator activity;other molecular function" "Pf00566, Pf02893" "23061" "ENSG00000197226; ENSG00000284400" "TBC1D9B" "D3DWQ5; D3DWQ6; hsa:23061; O75163; Q53EY0; Q66K14; Q6MZI2; Q96H49" "" "" "0" "0" "1.063" "1.012" "0.954" "1.009" "1.013" "1.059" "0.999" "1.067" "1.053" "723.7" "769.2" "732.3" "690.4" "730.0" "733.2" "766.3" "723.1" "772.1" "762.0" "" "" "" "" "" "" "" "" "" "" "650.7" "622.4" "662.3" "673.9" "602.4" "733.2" "573.8" "638.7" "690.9" "272.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408617602849881412" "False" "High" "IsMasterProtein" "Q9UKU7" "Isobutyryl-CoA dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=ACAD8 PE=1 SV=1" "0.000" "False" "22.951" "18" "7" "9" "7" "415" "45.0" "7.85" "27.87" "7" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00441, Pf02770, Pf02771" "27034" "ENSG00000151498" "ACAD8" "B7Z5W4; hsa:27034; Q6ZWP6; Q9BUS8; Q9UKU7" "" "Branched-chain amino acid catabolism; Mitochondrial protein degradation" "2" "0" "1.092" "1.081" "1.035" "1.111" "1.050" "1.081" "1.062" "1.162" "0.857" "666.6" "727.7" "720.8" "690.1" "740.4" "699.7" "720.7" "707.7" "774.6" "571.4" "" "" "" "" "" "" "" "" "" "" "599.3" "588.9" "652.0" "673.6" "611.0" "699.7" "539.6" "625.1" "693.1" "204.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3451849306749892991" "False" "High" "IsMasterProtein" "P49459" "Ubiquitin-conjugating enzyme E2 A OS=Homo sapiens OX=9606 GN=UBE2A PE=1 SV=2" "0.000" "False" "22.947" "31" "3" "7" "2" "152" "17.3" "5.15" "42.51" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7319" "ENSG00000077721" "UBE2A" "A6NFE9; A6NGR2; A6NMF5; B2R7R9; D3DWI1; hsa:7319; P49459; Q4TTG1; Q96FX4" "" "E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "3" "2" "0.938" "1.150" "0.997" "1.039" "1.105" "0.929" "1.043" "1.150" "0.825" "1004.1" "941.9" "1155.0" "1001.3" "1043.1" "1110.0" "933.0" "1047.3" "1154.4" "828.4" "" "" "" "" "" "" "" "" "" "" "902.8" "762.2" "1044.7" "977.4" "860.8" "1110.0" "698.6" "925.0" "1032.9" "295.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8657126207816692356" "False" "High" "IsMasterProtein" "O43422" "52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens OX=9606 GN=THAP12 PE=1 SV=2" "0.000" "False" "22.929" "11" "7" "7" "7" "761" "87.6" "5.86" "26.96" "7" "signal transduction;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf05699, Pf14291" "5612" "ENSG00000137492" "THAP12" "A8K728; hsa:5612; O43422; Q17RY9; Q8WTW1; Q9Y3Z4" "" "" "0" "0" "1.005" "0.968" "1.020" "0.965" "0.990" "1.106" "0.983" "1.033" "0.684" "454.3" "456.5" "439.7" "463.3" "438.3" "449.8" "502.4" "446.6" "469.5" "310.8" "" "" "" "" "" "" "" "" "" "" "408.5" "369.4" "397.7" "452.3" "361.7" "449.8" "376.2" "394.5" "420.1" "111.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1391272447933749932" "False" "High" "IsMasterProtein" "Q9UNI6" "Dual specificity protein phosphatase 12 OS=Homo sapiens OX=9606 GN=DUSP12 PE=1 SV=1" "0.000" "False" "22.913" "23" "7" "7" "7" "340" "37.7" "6.84" "25.49" "7" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00782" "11266" "ENSG00000081721" "DUSP12" "hsa:11266; Q5VXA8; Q9UNI6" "" "" "0" "0" "1.083" "1.058" "0.954" "1.013" "1.049" "0.981" "1.016" "1.043" "1.021" "245.2" "265.7" "259.3" "234.0" "248.3" "257.3" "240.6" "249.1" "255.7" "250.4" "" "" "" "" "" "" "" "" "" "" "220.5" "215.0" "234.6" "228.4" "204.9" "257.3" "180.1" "220.0" "228.8" "89.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6107269265140402008" "False" "High" "IsMasterProtein" "P10109" "Adrenodoxin, mitochondrial OS=Homo sapiens OX=9606 GN=FDX1 PE=1 SV=1" "0.000" "False" "22.895" "38" "7" "10" "7" "184" "19.4" "5.83" "33.90" "7" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00111" "2230" "ENSG00000137714" "FDX1" "B0YJ14; hsa:2230; P10109; Q53YD6" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "6" "0" "0.913" "0.972" "0.921" "1.027" "0.969" "1.019" "1.028" "0.975" "0.747" "1089.4" "994.3" "1058.9" "1003.8" "1119.3" "1055.3" "1109.8" "1119.7" "1062.6" "814.2" "" "" "" "" "" "" "" "" "" "" "979.5" "804.5" "957.8" "979.8" "923.7" "1055.3" "831.0" "989.0" "950.8" "290.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088025864314276117" "False" "High" "IsMasterProtein" "O95793" "Double-stranded RNA-binding protein Staufen homolog 1 OS=Homo sapiens OX=9606 GN=STAU1 PE=1 SV=2" "0.000" "False" "22.887" "13" "7" "10" "7" "577" "63.1" "9.44" "27.57" "7" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035, Pf16482" "6780" "ENSG00000124214" "STAU1" "A8K9Z4; E1P5Y1; E1P608; hsa:6780; O95793; Q5JW29; Q6GTM4; Q9H5B4; Q9H5B5; Q9Y3Q2" "" "" "0" "0" "0.886" "0.918" "0.874" "0.904" "0.984" "0.890" "0.894" "0.887" "0.831" "637.1" "564.6" "584.9" "556.6" "575.7" "627.0" "566.8" "569.5" "565.2" "529.7" "" "" "" "" "" "" "" "" "" "" "572.8" "456.8" "529.1" "543.3" "475.1" "627.0" "424.4" "503.0" "505.8" "189.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5875198809388005970" "False" "High" "IsMasterProtein" "Q9H3H3" "UPF0696 protein C11orf68 OS=Homo sapiens OX=9606 GN=C11orf68 PE=1 SV=3" "0.000" "False" "22.839" "24" "6" "7" "6" "292" "31.4" "6.32" "25.91" "6" "" "" "" "Pf08939" "83638" "ENSG00000175573" "C11orf68" "hsa:83638; J3KQG9; Q9BT13; Q9H3H3" "" "" "0" "0" "0.899" "0.939" "0.931" "0.878" "0.859" "0.844" "0.942" "0.922" "0.728" "1186.8" "1066.5" "1114.5" "1104.8" "1041.6" "1019.8" "1001.7" "1117.8" "1094.8" "864.0" "" "" "" "" "" "" "" "" "" "" "1067.0" "863.0" "1008.1" "1078.4" "859.5" "1019.8" "750.0" "987.3" "979.6" "308.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8505612402410571852" "False" "High" "IsMasterProtein" "P17900" "Ganglioside GM2 activator OS=Homo sapiens OX=9606 GN=GM2A PE=1 SV=4" "0.000" "False" "22.837" "32" "6" "13" "6" "193" "20.8" "5.31" "48.11" "6" "other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf02221" "2760" "ENSG00000196743" "GM2A" "B2R699; D3DQH6; hsa:2760; P17900; Q14426; Q14428; Q6LBL5" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism" "3" "0" "0.958" "0.992" "1.036" "1.088" "0.929" "1.066" "1.038" "1.012" "0.766" "1861.6" "1783.5" "1846.3" "1928.4" "2026.2" "1728.8" "1983.8" "1932.2" "1884.4" "1425.8" "" "" "" "" "" "" "" "" "" "" "1673.7" "1443.1" "1670.0" "1882.4" "1672.0" "1728.8" "1485.4" "1706.7" "1686.1" "509.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "400708693502021351" "False" "High" "IsMasterProtein" "Q12857" "Nuclear factor 1 A-type OS=Homo sapiens OX=9606 GN=NFIA PE=1 SV=2" "0.000" "False" "22.831" "13" "7" "7" "7" "509" "55.9" "8.44" "25.01" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00859, Pf03165, Pf10524" "4774" "ENSG00000162599" "NFIA" "B4DRJ3; B4DS53; F5H0R0; F8W8W3; hsa:4774; Q12857; Q8TA97; Q9H3X9; Q9P2A9" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Termination" "2" "0" "1.025" "0.915" "1.044" "1.028" "0.957" "0.977" "1.055" "1.030" "0.917" "928.0" "950.9" "849.6" "968.9" "954.2" "888.1" "907.1" "979.3" "956.0" "851.1" "" "" "" "" "" "" "" "" "" "" "834.4" "769.4" "768.5" "945.8" "787.4" "888.1" "679.2" "865.0" "855.4" "303.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6651828163835198711" "False" "High" "IsMasterProtein" "O95997" "Securin OS=Homo sapiens OX=9606 GN=PTTG1 PE=1 SV=1" "0.000" "False" "22.827" "25" "5" "8" "5" "202" "22.0" "6.60" "30.26" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04856" "9232" "ENSG00000164611" "PTTG1" "hsa:9232; O95997" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition" "APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids" "5" "0" "1.019" "1.432" "0.990" "1.104" "1.389" "1.008" "1.106" "1.515" "1.202" "309.9" "315.9" "443.7" "306.7" "342.1" "430.5" "312.4" "342.7" "469.5" "372.6" "" "" "" "" "" "" "" "" "" "" "278.6" "255.6" "401.4" "299.4" "282.3" "430.5" "233.9" "302.7" "420.1" "133.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5356528915824417311" "False" "High" "IsMasterProtein" "Q7RTS9" "Dymeclin OS=Homo sapiens OX=9606 GN=DYM PE=1 SV=1" "0.000" "False" "22.810" "9" "7" "10" "7" "669" "75.9" "5.86" "31.26" "7" "cell organization and biogenesis;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf09742" "54808" "ENSG00000141627" "DYM" "A8K5I8; B2RCF9; B4DKI7; hsa:54808; Q3ZTS8; Q6P2P5; Q7RTS9; Q8N2M0; Q9BVE9; Q9NPU7" "" "" "0" "0" "1.059" "0.975" "0.925" "1.045" "0.960" "1.034" "0.922" "0.950" "1.020" "647.3" "685.7" "631.2" "599.0" "676.4" "621.3" "669.2" "596.6" "615.0" "660.1" "" "" "" "" "" "" "" "" "" "" "582.0" "554.8" "571.0" "584.7" "558.2" "621.3" "501.1" "526.9" "550.3" "235.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-60388765585118576" "False" "High" "IsMasterProtein" "Q9H875" "PRKR-interacting protein 1 OS=Homo sapiens OX=9606 GN=PRKRIP1 PE=1 SV=1" "0.000" "False" "22.790" "54" "8" "12" "8" "184" "21.0" "9.79" "36.63" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06658" "79706" "ENSG00000128563" "PRKRIP1" "B4DGM2; hsa:79706; Q8NDM6; Q96CF8; Q9H875" "" "mRNA Splicing - Major Pathway" "1" "0" "0.950" "0.936" "0.973" "0.990" "0.936" "1.047" "1.062" "1.003" "0.869" "944.6" "896.9" "883.7" "918.9" "935.4" "883.8" "989.1" "1002.8" "947.5" "820.8" "" "" "" "" "" "" "" "" "" "" "849.3" "725.8" "799.3" "897.0" "771.9" "883.8" "740.6" "885.7" "847.8" "293.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "576551174696518957" "False" "High" "IsMasterProtein" "Q5T447" "E3 ubiquitin-protein ligase HECTD3 OS=Homo sapiens OX=9606 GN=HECTD3 PE=1 SV=1" "0.000" "False" "22.784" "10" "7" "8" "7" "861" "97.1" "5.64" "29.24" "7" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00632, Pf03256" "79654" "ENSG00000126107" "HECTD3" "B3KPV7; B3KRH4; hsa:79654; Q5T447; Q5T448; Q9H783" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.046" "1.001" "0.948" "1.028" "1.057" "1.031" "1.058" "1.066" "1.125" "392.8" "410.8" "393.2" "372.4" "403.8" "415.2" "404.8" "415.6" "418.9" "441.7" "" "" "" "" "" "" "" "" "" "" "353.1" "332.4" "355.7" "363.5" "333.2" "415.2" "303.1" "367.1" "374.8" "157.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4835472215069796756" "False" "High" "IsMasterProtein" "Q9Y692" "Glucocorticoid modulatory element-binding protein 1 OS=Homo sapiens OX=9606 GN=GMEB1 PE=1 SV=2" "0.000" "False" "22.783" "16" "8" "9" "7" "573" "62.6" "4.83" "31.54" "8" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "10691" "ENSG00000162419" "GMEB1" "B1AT48; hsa:10691; Q9NWH1; Q9UKD0; Q9Y692" "2q37 copy number variation syndrome" "" "1" "1" "1.066" "1.051" "0.965" "0.998" "0.954" "1.069" "0.998" "1.034" "1.305" "344.3" "367.0" "361.9" "332.1" "343.5" "328.3" "368.0" "343.5" "356.0" "449.2" "" "" "" "" "" "" "" "" "" "" "309.6" "297.0" "327.3" "324.2" "283.4" "328.3" "275.5" "303.4" "318.6" "160.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1948996399981661341" "False" "High" "IsMasterProtein" "Q2TAL8" "Transcriptional regulator QRICH1 OS=Homo sapiens OX=9606 GN=QRICH1 PE=1 SV=1" "0.000" "False" "22.775" "9" "6" "7" "6" "776" "86.4" "5.87" "23.57" "6" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf12012" "54870" "ENSG00000198218" "QRICH1" "hsa:54870; Q2TAL8; Q4G0F7; Q7L621; Q8TEA5" "" "" "0" "0" "0.988" "0.953" "0.935" "0.954" "0.968" "1.011" "1.061" "0.974" "1.953" "253.3" "250.3" "241.4" "236.8" "241.6" "245.3" "256.2" "268.7" "246.7" "494.9" "" "" "" "" "" "" "" "" "" "" "227.8" "202.5" "218.4" "231.1" "199.4" "245.3" "191.9" "237.4" "220.7" "176.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8942814265025091180" "False" "High" "IsMasterProtein" "Q86U28" "Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA2 PE=1 SV=2" "0.000" "False" "22.701" "44" "6" "8" "6" "154" "16.5" "5.25" "30.52" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf01521" "122961" "ENSG00000165898" "ISCA2" "A6NFF1; A8K3W3; G3V291; hsa:122961; Q86U28; Q8IYZ0; Q96BB2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "1.036" "0.962" "0.998" "1.054" "1.079" "1.050" "1.032" "1.076" "1.070" "385.8" "399.7" "371.0" "385.0" "406.6" "416.4" "405.0" "398.0" "415.2" "412.7" "" "" "" "" "" "" "" "" "" "" "346.9" "323.4" "335.6" "375.9" "335.6" "416.4" "303.2" "351.6" "371.5" "147.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-126462466589207022" "False" "High" "IsMasterProtein" "P18440" "Arylamine N-acetyltransferase 1 OS=Homo sapiens OX=9606 GN=NAT1 PE=1 SV=2" "0.000" "False" "22.618" "29" "7" "7" "7" "290" "33.9" "6.54" "25.64" "7" "other metabolic processes" "cytosol" "other molecular function" "Pf00797" "9" "ENSG00000171428" "NAT1" "A8K4E7; hsa:9; O15159; O15300; P18440; Q546N1; Q96TE9" "Omega-6-fatty acids in senescence; Arylamine metabolism; Metapathway biotransformation Phase I and II" "Paracetamol ADME; Acetylation" "5" "0" "0.949" "1.022" "0.885" "0.928" "0.945" "0.950" "0.811" "0.970" "2.809" "618.4" "587.1" "631.8" "547.3" "574.0" "584.1" "587.8" "501.3" "599.9" "1737.0" "" "" "" "" "" "" "" "" "" "" "556.0" "475.1" "571.5" "534.2" "473.7" "584.1" "440.1" "442.7" "536.8" "620.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8481325661535348808" "False" "High" "IsMasterProtein" "P46019" "Phosphorylase b kinase regulatory subunit alpha, liver isoform OS=Homo sapiens OX=9606 GN=PHKA2 PE=1 SV=1" "0.000" "False" "22.617" "6" "7" "7" "7" "1235" "138.3" "6.44" "28.09" "7" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00723, Pf19292" "5256" "ENSG00000044446" "PHKA2" "A8K1T1; hsa:5256; P46019; Q6LAJ5; Q7Z6W0; Q96CR3; Q9UDA1" "Type II diabetes mellitus; Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "3" "0" "1.032" "0.989" "0.911" "0.949" "0.906" "0.935" "1.023" "0.954" "1.033" "321.6" "331.8" "318.2" "293.1" "305.2" "291.3" "300.7" "329.1" "306.9" "332.4" "" "" "" "" "" "" "" "" "" "" "289.2" "268.5" "287.8" "286.1" "251.8" "291.3" "225.2" "290.7" "274.6" "118.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5845419377566949929" "False" "High" "IsMasterProtein" "P61077" "Ubiquitin-conjugating enzyme E2 D3 OS=Homo sapiens OX=9606 GN=UBE2D3 PE=1 SV=1" "0.000" "False" "22.606" "41" "4" "9" "1" "147" "16.7" "7.80" "30.35" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00179" "7323" "ENSG00000109332" "UBE2D3" "A6NJ93; A6NJB1; A6NM99; P47986; P61077; Q6IB88; Q6NXS4; Q8N924" "Proteasome degradation" "Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Neddylation; IKK complex recruitment mediated by RIP1; Signaling by BMP; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "13" "3" "1.028" "0.969" "0.977" "1.001" "0.919" "1.029" "0.953" "0.967" "0.822" "725.6" "746.2" "703.0" "709.2" "726.4" "666.8" "746.7" "691.6" "701.8" "596.1" "" "" "" "" "" "" "" "" "" "" "652.4" "603.8" "635.9" "692.2" "599.4" "666.8" "559.1" "610.8" "628.0" "212.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "938742805709954505" "False" "High" "IsMasterProtein" "Q9H3F6" "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens OX=9606 GN=KCTD10 PE=1 SV=1" "0.000" "False" "22.605" "20" "7" "7" "7" "313" "35.4" "6.34" "25.94" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02214" "83892" "ENSG00000110906" "KCTD10" "hsa:83892; Q53HN2; Q59FV1; Q6PL47; Q96SU0; Q9H3F6" "" "" "0" "0" "1.088" "1.135" "0.900" "1.059" "1.068" "0.970" "0.938" "1.071" "1.104" "221.1" "240.5" "250.9" "199.1" "234.1" "236.1" "214.5" "207.4" "236.9" "244.1" "" "" "" "" "" "" "" "" "" "" "198.8" "194.6" "227.0" "194.4" "193.2" "236.1" "160.6" "183.1" "212.0" "87.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6534484608378348231" "False" "High" "IsMasterProtein" "Q9H000" "E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens OX=9606 GN=MKRN2 PE=1 SV=2" "0.000" "False" "22.592" "14" "7" "11" "7" "416" "46.9" "7.61" "28.67" "7" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00097, Pf00642, Pf14608" "23609" "ENSG00000075975" "MKRN2" "A6NIA2; B3KRC5; B4DPR4; Q8N391; Q96BD4; Q9BUY2; Q9H000; Q9NRY1" "" "" "0" "0" "1.026" "1.052" "0.982" "1.031" "1.040" "1.032" "1.049" "1.065" "1.378" "361.8" "371.0" "380.5" "355.1" "373.1" "376.3" "373.5" "379.4" "385.4" "498.7" "" "" "" "" "" "" "" "" "" "" "325.3" "300.2" "344.1" "346.6" "307.9" "376.3" "279.7" "335.1" "344.8" "178.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621637110793391590" "False" "High" "IsMasterProtein" "Q9BV79" "Enoyl-[acyl-carrier-protein] reductase, mitochondrial OS=Homo sapiens OX=9606 GN=MECR PE=1 SV=2" "0.000" "False" "22.587" "21" "8" "9" "8" "373" "40.4" "8.76" "30.20" "8" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00107, Pf08240" "51102" "ENSG00000116353" "MECR" "B3KT72; Q5SYU0; Q5SYU1; Q5SYU2; Q6IBU9; Q9BV79; Q9Y373" "Fatty acid biosynthesis; Mitochondrial fatty acid synthesis pathway" "Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA" "3" "0" "1.100" "1.023" "1.009" "1.108" "1.037" "1.016" "1.155" "1.093" "1.062" "810.4" "891.4" "829.2" "818.0" "898.1" "840.2" "823.7" "936.0" "885.8" "860.9" "" "" "" "" "" "" "" "" "" "" "728.7" "721.3" "750.1" "798.5" "741.2" "840.2" "616.8" "826.7" "792.6" "307.3" "7" "7" "7" "7" "7" "7" "7" "7" "7" "7" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279905099390366435" "False" "High" "IsMasterProtein" "Q6FIF0" "AN1-type zinc finger protein 6 OS=Homo sapiens OX=9606 GN=ZFAND6 PE=1 SV=2" "0.000" "False" "22.559" "26" "4" "8" "4" "208" "22.5" "7.20" "30.43" "4" "cell organization and biogenesis;other biological processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "54469" "ENSG00000086666" "ZFAND6" "D3DW92; D3DW94; hsa:54469; O95792; Q6FIF0; Q9BQF7; Q9GZY3" "" "Peroxisomal protein import" "1" "0" "0.913" "0.888" "0.977" "0.912" "0.937" "0.917" "0.936" "0.889" "0.725" "929.3" "848.0" "825.7" "907.6" "847.5" "871.2" "851.7" "869.9" "826.5" "674.0" "" "" "" "" "" "" "" "" "" "" "835.5" "686.2" "746.9" "885.9" "699.4" "871.2" "637.7" "768.3" "739.5" "240.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7745810489150015985" "False" "High" "IsMasterProtein" "O95292" "Vesicle-associated membrane protein-associated protein B/C OS=Homo sapiens OX=9606 GN=VAPB PE=1 SV=3" "0.000" "False" "22.547" "22" "5" "8" "4" "243" "27.2" "7.30" "31.11" "5" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00635" "9217" "ENSG00000124164" "VAPB" "A2A2F2; hsa:9217; O95292; O95293; Q9P0H0" "Ciliary landscape" "Sphingolipid de novo biosynthesis; RHOC GTPase cycle; RHOA GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RHOD GTPase cycle" "7" "0" "0.989" "0.930" "1.058" "1.171" "0.980" "1.223" "1.044" "1.027" "0.797" "382.6" "378.6" "355.8" "405.0" "448.1" "374.9" "467.8" "399.5" "393.1" "305.0" "" "" "" "" "" "" "" "" "" "" "344.0" "306.3" "321.8" "395.3" "369.8" "374.9" "350.3" "352.9" "351.8" "108.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441790046039018783" "False" "High" "IsMasterProtein" "Q9UQN3" "Charged multivesicular body protein 2b OS=Homo sapiens OX=9606 GN=CHMP2B PE=1 SV=1" "0.000" "False" "22.533" "23" "5" "8" "5" "213" "23.9" "8.76" "28.63" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "25978" "ENSG00000083937" "CHMP2B" "B4DJG8; hsa:25978; Q53HC7; Q9UQN3; Q9Y4U6" "" "Budding and maturation of HIV virion; Macroautophagy; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Late endosomal microautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.936" "1.074" "0.994" "0.980" "1.050" "1.003" "1.045" "1.004" "0.907" "858.7" "804.0" "922.4" "853.8" "841.2" "901.8" "861.6" "897.4" "862.2" "778.7" "" "" "" "" "" "" "" "" "" "" "772.0" "650.6" "834.3" "833.4" "694.2" "901.8" "645.2" "792.7" "771.5" "278.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441805136985848157" "False" "High" "IsMasterProtein" "Q8TB52" "F-box only protein 30 OS=Homo sapiens OX=9606 GN=FBXO30 PE=1 SV=3" "0.000" "False" "22.479" "8" "5" "7" "5" "745" "82.3" "5.40" "25.68" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf15965, Pf15966" "84085" "ENSG00000118496" "FBXO30" "hsa:84085; Q8TB52; Q9BXZ7" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.032" "1.006" "1.008" "1.258" "0.956" "1.177" "1.135" "0.997" "1.215" "154.2" "159.1" "155.1" "155.5" "193.9" "147.4" "181.4" "175.0" "153.7" "187.3" "" "" "" "" "" "" "" "" "" "" "138.6" "128.7" "140.3" "151.8" "160.0" "147.4" "135.8" "154.5" "137.6" "66.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3347831162215749093" "False" "High" "IsMasterProtein" "Q9UEW8" "STE20/SPS1-related proline-alanine-rich protein kinase OS=Homo sapiens OX=9606 GN=STK39 PE=1 SV=3" "0.000" "False" "22.473" "14" "6" "6" "5" "545" "59.4" "6.29" "23.86" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12202" "27347" "ENSG00000198648" "STK39" "O14774; Q53S90; Q53SL7; Q53SS1; Q9UER4; Q9UEW8; X5D9C8" "" "" "0" "0" "0.933" "0.870" "0.899" "0.966" "0.932" "1.043" "0.869" "0.971" "4.131" "224.6" "209.5" "195.4" "201.9" "217.0" "209.4" "234.2" "195.2" "218.0" "927.6" "" "" "" "" "" "" "" "" "" "" "201.9" "169.5" "176.8" "197.1" "179.1" "209.4" "175.4" "172.4" "195.1" "331.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2902136520496705703" "False" "High" "IsMasterProtein" "Q8N3F8" "MICAL-like protein 1 OS=Homo sapiens OX=9606 GN=MICALL1 PE=1 SV=2" "0.000" "False" "22.449" "11" "7" "9" "7" "863" "93.4" "7.25" "29.14" "7" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00307, Pf00412, Pf12130" "85377" "ENSG00000100139" "MICALL1" "hsa:85377; Q5TI16; Q7RTP5; Q8N3F8; Q8N3N8; Q9BVL9; Q9BY92; Q9UH43; Q9UH44; Q9UH45" "" "" "0" "0" "0.941" "0.931" "0.905" "1.044" "0.884" "0.940" "0.866" "0.902" "0.747" "383.7" "360.9" "357.3" "347.1" "400.7" "339.0" "360.7" "332.4" "346.3" "286.7" "" "" "" "" "" "" "" "" "" "" "345.0" "292.0" "323.2" "338.9" "330.6" "339.0" "270.1" "293.6" "309.8" "102.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2311185762453524816" "False" "High" "IsMasterProtein" "O95905" "Protein ecdysoneless homolog OS=Homo sapiens OX=9606 GN=ECD PE=1 SV=1" "0.000" "False" "22.442" "12" "8" "8" "8" "644" "72.7" "4.87" "26.26" "8" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf07093" "11319" "ENSG00000122882" "ECD" "C9JX46; E9PAW8; hsa:11319; O95905" "" "" "0" "0" "0.965" "1.020" "0.913" "0.960" "0.991" "0.966" "0.950" "1.086" "1.374" "914.3" "882.1" "932.7" "835.1" "877.9" "906.3" "883.1" "868.6" "992.5" "1256.5" "" "" "" "" "" "" "" "" "" "" "822.1" "713.8" "843.7" "815.2" "724.5" "906.3" "661.2" "767.2" "888.1" "448.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3739343134974919134" "False" "High" "IsMasterProtein" "Q92804" "TATA-binding protein-associated factor 2N OS=Homo sapiens OX=9606 GN=TAF15 PE=1 SV=1" "0.000" "False" "22.442" "11" "4" "11" "2" "592" "61.8" "8.02" "37.20" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "8148" "ENSG00000270647; ENSG00000276833" "TAF15" "B2R837; hsa:8148; Q86X94; Q92751; Q92804" "17q12 copy number variation syndrome" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "10" "0" "0.903" "0.957" "0.947" "1.002" "0.938" "0.984" "1.028" "1.008" "1.060" "77.2" "69.7" "73.9" "73.1" "77.3" "72.4" "75.9" "79.3" "77.8" "81.8" "" "" "" "" "" "" "" "" "" "" "69.4" "56.4" "66.8" "71.4" "63.8" "72.4" "56.9" "70.1" "69.6" "29.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6609542144732775052" "False" "High" "IsMasterProtein" "Q92615" "La-related protein 4B OS=Homo sapiens OX=9606 GN=LARP4B PE=1 SV=3" "0.000" "False" "22.427" "11" "9" "12" "9" "738" "80.5" "6.92" "35.14" "9" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05383" "23185" "ENSG00000107929" "LARP4B" "A7MD20; hsa:23185; Q5T3R3; Q5T3R4; Q5T3R5; Q68CY4; Q92615" "" "" "0" "0" "1.002" "0.938" "1.003" "0.982" "1.040" "1.169" "1.004" "0.939" "1.374" "375.0" "375.7" "351.8" "376.2" "368.1" "390.0" "438.2" "376.4" "352.1" "515.4" "" "" "" "" "" "" "" "" "" "" "337.2" "304.0" "318.2" "367.3" "303.8" "390.0" "328.1" "332.5" "315.1" "184.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2750317325017084074" "False" "High" "IsMasterProtein" "Q12962" "Transcription initiation factor TFIID subunit 10 OS=Homo sapiens OX=9606 GN=TAF10 PE=1 SV=1" "0.000" "False" "22.401" "26" "4" "5" "4" "218" "21.7" "6.57" "29.43" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03540" "6881" "ENSG00000166337" "TAF10" "hsa:6881; O00703; Q12962; Q13175; Q6FH13" "" "Ub-specific processing proteases; HATs acetylate histones; Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "11" "0" "1.066" "0.998" "0.896" "1.079" "1.105" "0.959" "1.061" "1.039" "0.862" "153.2" "163.4" "152.9" "137.3" "165.3" "169.4" "147.0" "162.6" "159.2" "132.2" "" "" "" "" "" "" "" "" "" "" "137.8" "132.2" "138.3" "134.0" "136.4" "169.4" "110.0" "143.6" "142.5" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5652063056633213151" "False" "High" "IsMasterProtein" "Q9Y4C4" "Malignant fibrous histiocytoma-amplified sequence 1 OS=Homo sapiens OX=9606 GN=MFHAS1 PE=1 SV=2" "0.000" "False" "22.398" "7" "7" "7" "7" "1052" "116.9" "7.88" "26.64" "7" "stress response;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf13855" "9258" "ENSG00000147324" "MFHAS1" "hsa:9258; Q96CI0; Q9Y4C4" "8p23.1 copy number variation syndrome" "" "1" "0" "1.090" "0.936" "0.991" "1.105" "0.906" "1.063" "1.046" "0.876" "1.325" "516.6" "562.9" "483.8" "512.2" "570.9" "468.3" "549.3" "540.3" "452.3" "684.7" "" "" "" "" "" "" "" "" "" "" "464.5" "455.5" "437.6" "500.0" "471.1" "468.3" "411.3" "477.3" "404.7" "244.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9082551203190853772" "False" "High" "IsMasterProtein" "Q16777" "Histone H2A type 2-C OS=Homo sapiens OX=9606 GN=H2AC20 PE=1 SV=4" "0.000" "False" "22.389" "36" "5" "16" "2" "129" "14.0" "10.90" "52.74" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "8338" "ENSG00000184260" "H2AC20" "hsa:8338; Q16777; Q6DRA7; Q8IUE5" "" "Formation of the beta-catenin:TCF transactivating complex; Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Ub-specific processing proteases; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; Amyloid fiber formation; Meiotic synapsis; HCMV Late Events; UCH proteinases; RUNX1 regulates transcription of genes involved in differentiation of HSCs; HCMV Early Events; Deposition of new CENPA-containing nucleosomes at the centromere; Oxidative Stress Induced Senescence; HDACs deacetylate histones; Metalloprotease DUBs; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; HATs acetylate histones; Chromatin modifications during the maternal to zygotic transition (MZT); Meiotic recombination; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "42" "0" "0.981" "0.746" "1.003" "1.034" "1.050" "0.916" "1.078" "0.751" "0.775" "285.0" "279.6" "212.6" "285.8" "294.6" "299.3" "260.9" "307.2" "214.1" "220.9" "" "" "" "" "" "" "" "" "" "" "256.2" "226.2" "192.3" "279.0" "243.1" "299.3" "195.4" "271.4" "191.6" "78.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4939449039103849626" "False" "High" "IsMasterProtein" "Q96G74" "OTU domain-containing protein 5 OS=Homo sapiens OX=9606 GN=OTUD5 PE=1 SV=1" "0.000" "False" "22.377" "16" "6" "7" "6" "571" "60.6" "6.54" "26.08" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf02338" "55593" "ENSG00000068308; ENSG00000292211" "OTUD5" "B4DGG7; G5E9D7; hsa:55593; Q4KMN9; Q8N6T5; Q96G74; Q9H650; Q9H9U0; Q9NT65" "Gastric cancer network 2; Novel intracellular components of RIG-I-like receptor pathway" "Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases" "4" "0" "1.010" "1.088" "0.945" "1.086" "1.015" "1.048" "0.998" "1.071" "0.963" "406.7" "410.9" "442.4" "384.5" "441.4" "412.6" "426.2" "406.0" "435.5" "391.7" "" "" "" "" "" "" "" "" "" "" "365.6" "332.5" "400.2" "375.3" "364.3" "412.6" "319.1" "358.6" "389.7" "139.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6104257487773187704" "False" "High" "IsMasterProtein" "Q0PNE2" "Elongator complex protein 6 OS=Homo sapiens OX=9606 GN=ELP6 PE=1 SV=1" "0.000" "False" "22.376" "27" "7" "7" "7" "266" "29.8" "6.84" "25.98" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf09807" "54859" "ENSG00000163832" "ELP6" "hsa:54859; Q0PNE2; Q9BW57; Q9NXJ3" "" "HATs acetylate histones" "1" "0" "1.066" "1.001" "0.992" "1.065" "1.006" "1.061" "1.018" "1.013" "0.848" "658.4" "701.7" "658.9" "653.4" "701.2" "662.4" "698.4" "670.1" "666.7" "558.2" "" "" "" "" "" "" "" "" "" "" "592.0" "567.8" "596.0" "637.8" "578.6" "662.4" "522.9" "591.9" "596.6" "199.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1136276274869286846" "False" "High" "IsMasterProtein" "Q9NVR2" "Integrator complex subunit 10 OS=Homo sapiens OX=9606 GN=INTS10 PE=1 SV=2" "0.000" "False" "22.332" "10" "7" "8" "7" "710" "82.2" "7.44" "20.93" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf21045" "55174" "ENSG00000104613" "INTS10" "hsa:55174; Q6IA93; Q7L538; Q7L8C8; Q9H3W8; Q9NVR2" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "1.037" "1.089" "0.983" "0.981" "1.069" "0.948" "0.998" "0.984" "1.241" "402.0" "416.7" "437.7" "395.3" "394.4" "429.5" "381.0" "401.0" "395.5" "499.0" "" "" "" "" "" "" "" "" "" "" "361.4" "337.2" "395.9" "385.8" "325.4" "429.5" "285.3" "354.2" "353.9" "178.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8766767178054047588" "False" "High" "IsMasterProtein" "Q9BYC9" "Large ribosomal subunit protein bL20m OS=Homo sapiens OX=9606 GN=MRPL20 PE=1 SV=1" "0.000" "False" "22.322" "37" "6" "10" "6" "149" "17.4" "10.86" "27.22" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00453" "55052" "ENSG00000242485" "MRPL20" "B2RE41; B7Z746; hsa:55052; Q9BYC9" "1p36 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "1.041" "1.006" "0.960" "1.061" "0.961" "0.977" "1.014" "1.091" "1.075" "507.8" "528.7" "510.9" "487.8" "538.8" "488.2" "495.9" "515.1" "553.9" "546.0" "" "" "" "" "" "" "" "" "" "" "456.6" "427.8" "462.1" "476.1" "444.6" "488.2" "371.3" "455.0" "495.7" "194.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643109724268830478" "False" "High" "IsMasterProtein" "Q8WUH1" "Protein Churchill OS=Homo sapiens OX=9606 GN=CHURC1 PE=1 SV=3" "0.000" "False" "22.321" "33" "4" "7" "4" "112" "12.9" "4.84" "26.94" "4" "signal transduction;other biological processes" "" "other molecular function" "Pf06573" "91612" "ENSG00000258289" "CHURC1" "A0A0C4DGJ7; B3KQ81; G3V1X3; G3V214; hsa:91612; Q8WUH1; Q9H3K7" "" "" "0" "0" "0.879" "0.995" "0.908" "0.966" "0.900" "0.913" "0.961" "1.011" "0.819" "726.2" "638.5" "722.2" "659.7" "701.2" "653.7" "663.0" "698.0" "734.3" "594.9" "" "" "" "" "" "" "" "" "" "" "652.9" "516.7" "653.3" "643.9" "578.6" "653.7" "496.4" "616.6" "657.0" "212.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6736379060781022662" "False" "High" "IsMasterProtein" "P21399" "Cytoplasmic aconitate hydratase OS=Homo sapiens OX=9606 GN=ACO1 PE=1 SV=3" "0.000" "False" "22.312" "8" "8" "11" "8" "889" "98.3" "6.68" "30.12" "8" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;ER/Golgi;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "48" "ENSG00000122729" "ACO1" "D3DRK7; hsa:48; P21399; Q14652; Q5VZA7" "Iron metabolism in placenta; TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc)" "Iron uptake and transport" "3" "0" "1.104" "1.094" "0.996" "1.149" "1.109" "1.120" "1.048" "1.088" "1.000" "584.8" "645.7" "639.9" "582.4" "671.8" "648.7" "654.9" "612.6" "636.2" "584.8" "" "" "" "" "" "" "" "" "" "" "525.8" "522.5" "578.8" "568.5" "554.4" "648.7" "490.4" "541.1" "569.2" "208.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4363739394428502664" "False" "High" "IsMasterProtein" "O75330" "Hyaluronan mediated motility receptor OS=Homo sapiens OX=9606 GN=HMMR PE=1 SV=2" "0.000" "False" "22.292" "9" "7" "7" "7" "724" "84.0" "5.83" "25.25" "7" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf15905, Pf15908" "3161" "ENSG00000072571" "HMMR" "A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0; hsa:3161; O75330; Q32N02; Q92767" "" "AURKA Activation by TPX2; Hyaluronan uptake and degradation" "2" "0" "1.028" "1.188" "1.018" "1.107" "1.198" "1.120" "1.120" "1.243" "3.019" "288.5" "296.5" "342.7" "293.7" "319.3" "345.5" "323.1" "323.2" "358.6" "870.9" "" "" "" "" "" "" "" "" "" "" "259.4" "239.9" "310.0" "286.7" "263.5" "345.5" "241.9" "285.5" "320.8" "310.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5828949100496623215" "False" "High" "IsMasterProtein" "Q92844" "TRAF family member-associated NF-kappa-B activator OS=Homo sapiens OX=9606 GN=TANK PE=1 SV=2" "0.000" "False" "22.277" "13" "5" "7" "5" "425" "47.8" "5.68" "25.49" "5" "stress response;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf12845" "10010" "ENSG00000136560" "TANK" "D3DPB5; hsa:10010; Q7Z4J6; Q92844; Q92885" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Novel intracellular components of RIG-I-like receptor pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response" "Activation of IRF3, IRF7 mediated by TBK1, IKBKE; TICAM1-dependent activation of IRF3/IRF7; TRAF6 mediated IRF7 activation" "7" "0" "0.845" "1.128" "0.976" "0.902" "1.000" "1.001" "1.066" "1.219" "1.224" "70.4" "59.5" "79.5" "68.8" "63.5" "70.4" "70.5" "75.1" "85.9" "86.3" "" "" "" "" "" "" "" "" "" "" "63.3" "48.2" "71.9" "67.1" "52.4" "70.4" "52.8" "66.3" "76.8" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7388585802174213380" "False" "High" "IsMasterProtein" "Q06187" "Tyrosine-protein kinase BTK OS=Homo sapiens OX=9606 GN=BTK PE=1 SV=3" "0.000" "False" "22.254" "11" "6" "6" "6" "659" "76.2" "7.77" "22.31" "6" "cell-cell signaling;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf00169, Pf00779, Pf07714" "695" "ENSG00000010671" "BTK" "B2RAW1; hsa:695; Q06187; Q32ML5" "IL-5 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; Kit receptor signaling pathway; 7q11.23 copy number variation syndrome; Genetic causes of porto-sinusoidal vascular disease" "FCGR3A-mediated phagocytosis; ER-Phagosome pathway; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; G alpha (12/13) signalling events; G alpha (q) signalling events; RHO GTPases Activate WASPs and WAVEs; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); DAP12 signaling; G beta:gamma signalling through BTK" "20" "0" "0.961" "1.004" "0.928" "0.876" "0.943" "0.976" "0.852" "1.019" "4.343" "260.2" "250.2" "261.4" "241.5" "228.1" "245.3" "254.0" "221.8" "265.1" "1130.2" "" "" "" "" "" "" "" "" "" "" "234.0" "202.4" "236.4" "235.7" "188.2" "245.3" "190.2" "195.9" "237.2" "403.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334840059881177708" "False" "High" "IsMasterProtein" "Q16864" "V-type proton ATPase subunit F OS=Homo sapiens OX=9606 GN=ATP6V1F PE=1 SV=2" "0.000" "False" "22.244" "41" "4" "9" "4" "119" "13.4" "5.52" "33.28" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf01990" "9296" "ENSG00000128524" "ATP6V1F" "C9J2K4; hsa:9296; Q16864; Q6IBA8" "Proximal tubule transport" "ROS and RNS production in phagocytes; Amino acids regulate mTORC1; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "6" "0" "0.991" "1.042" "0.956" "1.071" "1.049" "1.028" "1.050" "1.021" "0.843" "845.0" "837.4" "880.4" "808.1" "904.7" "886.0" "868.3" "886.9" "862.8" "712.0" "" "" "" "" "" "" "" "" "" "" "759.7" "677.6" "796.4" "788.8" "746.6" "886.0" "650.1" "783.4" "772.0" "254.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3972038562420252503" "False" "High" "IsMasterProtein" "P61254" "Large ribosomal subunit protein uL24 OS=Homo sapiens OX=9606 GN=RPL26 PE=1 SV=1" "0.000" "False" "22.205" "36" "7" "11" "7" "145" "17.2" "10.55" "32.44" "7" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00467, Pf16906" "6154" "ENSG00000161970" "RPL26" "B2R4F0; D3DTR8; hsa:6154; P61254; Q02877; Q6IPY2" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.924" "0.929" "0.897" "0.920" "0.934" "0.904" "0.909" "0.977" "1.027" "1686.4" "1558.4" "1567.2" "1513.2" "1551.7" "1575.4" "1524.8" "1533.4" "1648.0" "1732.8" "" "" "" "" "" "" "" "" "" "" "1516.2" "1261.0" "1417.6" "1477.1" "1280.5" "1575.4" "1141.7" "1354.4" "1474.6" "618.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7302016058410828571" "False" "High" "IsMasterProtein" "O75940" "Survival of motor neuron-related-splicing factor 30 OS=Homo sapiens OX=9606 GN=SMNDC1 PE=1 SV=1" "0.000" "False" "22.197" "28" "5" "6" "5" "238" "26.7" "7.24" "25.55" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06003" "10285" "ENSG00000119953" "SMNDC1" "B2RA27; D3DRB1; hsa:10285; O75940; Q5T3K6" "" "mRNA Splicing - Major Pathway" "1" "0" "0.853" "0.911" "0.896" "1.005" "0.951" "0.943" "1.016" "0.969" "0.663" "565.2" "482.0" "514.8" "506.2" "568.2" "537.6" "533.0" "574.3" "547.7" "374.7" "" "" "" "" "" "" "" "" "" "" "508.2" "390.0" "465.6" "494.1" "468.9" "537.6" "399.1" "507.3" "490.0" "133.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8926086327643907621" "False" "High" "IsMasterProtein" "Q6XZF7" "Dynamin-binding protein OS=Homo sapiens OX=9606 GN=DNMBP PE=1 SV=1" "0.000" "False" "22.173" "5" "7" "7" "7" "1577" "177.2" "5.39" "25.78" "7" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity" "Pf00018, Pf00621, Pf03114, Pf07653, Pf14604" "23268" "ENSG00000107554" "DNMBP" "hsa:23268; Q6XZF7; Q8IVY3; Q9Y2L3" "15q11q13 copy number variation" "CDC42 GTPase cycle" "2" "0" "1.061" "1.029" "0.923" "1.093" "1.015" "1.076" "0.969" "1.117" "1.933" "641.0" "680.2" "659.7" "591.6" "700.4" "650.6" "689.7" "621.1" "716.0" "1239.1" "" "" "" "" "" "" "" "" "" "" "576.4" "550.4" "596.7" "577.5" "578.0" "650.6" "516.5" "548.6" "640.7" "442.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6445951316860718443" "False" "High" "IsMasterProtein" "O60343" "TBC1 domain family member 4 OS=Homo sapiens OX=9606 GN=TBC1D4 PE=1 SV=2" "0.000" "False" "22.101" "7" "8" "10" "6" "1298" "146.5" "7.01" "27.18" "8" "transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity" "Pf00566, Pf00640, Pf11830" "9882" "ENSG00000136111" "TBC1D4" "A7E2X8; B4DU25; B4E235; B6ETN8; B6ETN9; hsa:9882; O60343; Q5W0B9; Q68D14" "Ciliary landscape; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "4" "0" "0.968" "1.014" "0.932" "1.040" "1.044" "1.011" "0.938" "0.922" "0.997" "262.5" "254.2" "266.1" "244.6" "272.9" "274.0" "265.3" "246.2" "242.0" "261.8" "" "" "" "" "" "" "" "" "" "" "236.0" "205.7" "240.7" "238.8" "225.2" "274.0" "198.7" "217.4" "216.6" "93.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7307907366133705571" "False" "High" "IsMasterProtein" "Q9UJY4" "ADP-ribosylation factor-binding protein GGA2 OS=Homo sapiens OX=9606 GN=GGA2 PE=1 SV=3" "0.000" "False" "22.097" "13" "6" "6" "6" "613" "67.1" "6.55" "22.55" "6" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00790, Pf02883, Pf03127, Pf18308" "23062" "ENSG00000103365" "GGA2" "D3DWF0; hsa:23062; O14564; Q9NYN2; Q9UJY4; Q9UPS2" "" "Amyloid fiber formation; TBC/RABGAPs" "2" "0" "1.068" "1.046" "1.043" "1.057" "0.989" "1.112" "0.935" "0.990" "6.210" "490.0" "523.2" "512.6" "511.1" "518.0" "484.5" "544.9" "457.9" "485.1" "3042.5" "" "" "" "" "" "" "" "" "" "" "440.5" "423.4" "463.6" "498.9" "427.4" "484.5" "408.0" "404.4" "434.1" "1086.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721497203732723661" "False" "High" "IsMasterProtein" "P01591" "Immunoglobulin J chain OS=Homo sapiens OX=9606 GN=JCHAIN PE=1 SV=4" "0.000" "False" "22.046" "32" "5" "13" "5" "159" "18.1" "5.24" "37.58" "5" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf15097" "3512" "ENSG00000132465" "JCHAIN" "hsa:3512; P01591" "" "Cell surface interactions at the vascular wall; Scavenging of heme from plasma" "2" "0" "0.930" "0.930" "0.921" "1.017" "0.991" "0.938" "1.080" "1.008" "0.852" "624.2" "580.2" "580.3" "574.7" "634.8" "618.6" "585.5" "674.0" "629.3" "531.7" "" "" "" "" "" "" "" "" "" "" "561.2" "469.5" "524.9" "561.0" "523.8" "618.6" "438.4" "595.3" "563.1" "189.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2173979595876030532" "False" "High" "IsMasterProtein" "Q9Y4I1" "Unconventional myosin-Va OS=Homo sapiens OX=9606 GN=MYO5A PE=1 SV=2" "0.000" "False" "22.043" "4" "8" "9" "8" "1855" "215.3" "8.48" "27.17" "8" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf01843" "4644" "ENSG00000197535" "MYO5A" "A8MZC5; hsa:4644; O60653; Q07902; Q16249; Q9UE30; Q9UE31; Q9Y4I1" "Joubert syndrome; 2q37 copy number variation syndrome" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4223527727478599420" "False" "High" "IsMasterProtein" "Q9UBF8" "Phosphatidylinositol 4-kinase beta OS=Homo sapiens OX=9606 GN=PI4KB PE=1 SV=1" "0.000" "False" "21.942" "9" "6" "8" "6" "816" "91.3" "6.25" "23.91" "6" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454, Pf21245" "5298" "ENSG00000143393" "PI4KB" "B4DGI2; hsa:5298; O15096; P78405; Q5VWB9; Q5VWC0; Q5VWC1; Q9BWR6; Q9UBF8" "" "Synthesis of PIPs at the Golgi membrane" "1" "0" "0.953" "0.982" "0.898" "1.023" "0.932" "0.980" "1.013" "0.960" "0.878" "527.2" "502.6" "517.5" "473.2" "539.5" "491.1" "516.6" "534.1" "506.2" "462.8" "" "" "" "" "" "" "" "" "" "" "474.0" "406.7" "468.1" "461.9" "445.2" "491.1" "386.8" "471.7" "453.0" "165.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115257495252240726" "False" "High" "IsMasterProtein" "P82909" "Alpha-ketoglutarate dehydrogenase component 4 OS=Homo sapiens OX=9606 GN=KGD4 PE=1 SV=2" "0.000" "False" "21.936" "30" "3" "7" "3" "103" "11.5" "9.99" "29.64" "3" "other metabolic processes" "other membranes;mitochondrion" "" "" "92259" "ENSG00000134056; ENSG00000278461" "KGD4" "hsa:92259; P82909; Q9H2H4" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.989" "0.967" "0.949" "0.954" "1.025" "0.927" "0.978" "0.938" "0.841" "453.7" "448.9" "438.8" "430.6" "432.9" "465.2" "420.7" "443.5" "425.4" "381.8" "" "" "" "" "" "" "" "" "" "" "407.9" "363.3" "396.9" "420.4" "357.3" "465.2" "315.0" "391.7" "380.7" "136.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832536973652725080" "False" "High" "IsMasterProtein" "Q96C90" "Protein phosphatase 1 regulatory subunit 14B OS=Homo sapiens OX=9606 GN=PPP1R14B PE=1 SV=3" "0.000" "False" "21.927" "40" "4" "5" "4" "147" "15.9" "4.86" "31.06" "4" "stress response;other biological processes" "other cell component" "enzyme regulator activity" "Pf05361" "26472" "ENSG00000173457" "PPP1R14B" "hsa:26472; Q504S7; Q7KZD7; Q96C90" "" "" "0" "0" "0.954" "0.986" "1.051" "0.959" "1.076" "0.981" "1.100" "1.037" "0.935" "493.5" "470.7" "486.7" "518.4" "473.2" "531.2" "484.1" "542.6" "511.7" "461.2" "" "" "" "" "" "" "" "" "" "" "443.7" "380.8" "440.2" "506.0" "390.5" "531.2" "362.5" "479.2" "457.9" "164.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5248794698895072137" "False" "High" "IsMasterProtein" "Q9NVC6" "Mediator of RNA polymerase II transcription subunit 17 OS=Homo sapiens OX=9606 GN=MED17 PE=1 SV=2" "0.000" "False" "21.845" "10" "7" "7" "7" "651" "72.8" "7.44" "25.06" "7" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10156" "9440" "ENSG00000042429" "MED17" "B3KN07; hsa:9440; Q9HA81; Q9NVC6; Q9UNP7; Q9Y2W0; Q9Y660" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.994" "0.971" "0.882" "0.931" "0.930" "0.934" "0.948" "0.931" "1.107" "561.8" "558.4" "545.7" "495.8" "522.9" "522.7" "524.9" "532.6" "523.2" "622.2" "" "" "" "" "" "" "" "" "" "" "505.2" "451.9" "493.6" "484.0" "431.5" "522.7" "393.0" "470.4" "468.1" "222.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3479204083364141985" "False" "High" "IsMasterProtein" "Q96IY1" "Kinetochore-associated protein NSL1 homolog OS=Homo sapiens OX=9606 GN=NSL1 PE=1 SV=3" "0.000" "False" "21.807" "27" "7" "9" "7" "281" "32.1" "6.79" "36.10" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08641" "25936" "ENSG00000117697" "NSL1" "E7ETD5; hsa:25936; Q5SY75; Q96IY1; Q9H2M5; Q9NRN8; Q9Y415" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.993" "1.055" "0.981" "1.035" "1.095" "1.061" "0.996" "1.061" "1.032" "623.1" "618.6" "657.3" "611.5" "644.7" "682.3" "660.9" "620.7" "661.3" "642.8" "" "" "" "" "" "" "" "" "" "" "560.2" "500.5" "594.6" "596.9" "532.0" "682.3" "494.9" "548.3" "591.7" "229.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9075280951894741873" "False" "High" "IsMasterProtein" "Q9NQP4" "Prefoldin subunit 4 OS=Homo sapiens OX=9606 GN=PFDN4 PE=1 SV=1" "0.000" "False" "21.792" "34" "4" "9" "4" "134" "15.3" "4.53" "35.47" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01920" "5203" "ENSG00000101132" "PFDN4" "hsa:5203; Q5TD11; Q92779; Q9NQP4" "Cellular proteostasis" "Prefoldin mediated transfer of substrate to CCT/TriC" "2" "0" "0.888" "0.922" "0.831" "1.013" "0.958" "1.018" "0.917" "0.943" "0.792" "669.8" "595.0" "617.7" "556.5" "678.7" "641.9" "682.1" "614.4" "631.7" "530.3" "" "" "" "" "" "" "" "" "" "" "602.3" "481.4" "558.8" "543.2" "560.1" "641.9" "510.7" "542.6" "565.3" "189.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8248535501308075701" "False" "High" "IsMasterProtein" "P62879" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 OS=Homo sapiens OX=9606 GN=GNB2 PE=1 SV=3" "0.000" "False" "21.777" "18" "5" "7" "2" "340" "37.3" "6.00" "25.13" "5" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2783" "ENSG00000172354" "GNB2" "B3KPU1; hsa:2783; P11016; P54312; P62879" "Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "0.957" "0.897" "0.948" "0.989" "1.128" "1.001" "0.894" "1.282" "0.819" "129.5" "124.0" "116.1" "122.8" "128.1" "146.1" "129.6" "115.7" "166.0" "106.1" "" "" "" "" "" "" "" "" "" "" "116.4" "100.3" "105.0" "119.8" "105.7" "146.1" "97.0" "102.2" "148.6" "37.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3937524236337839102" "False" "High" "IsMasterProtein" "P32121" "Beta-arrestin-2 OS=Homo sapiens OX=9606 GN=ARRB2 PE=1 SV=2" "0.000" "False" "21.764" "18" "8" "9" "8" "409" "46.1" "7.69" "28.28" "8" "cell-cell signaling;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00339, Pf02752" "409" "ENSG00000141480" "ARRB2" "B4DLW0; B5B0C0; B7WPL3; D3DTK2; H0Y688; hsa:409; P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6" "Corticotropin-releasing hormone signaling pathway; Complement system; Myometrial relaxation and contraction pathways; Wnt signaling pathway; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Hedgehog signaling pathway; Gastrin signaling pathway; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Calcium regulation in cardiac cells" "Ub-specific processing proteases; Activated NOTCH1 Transmits Signal to the Nucleus; Cargo recognition for clathrin-mediated endocytosis; Activation of SMO; G alpha (s) signalling events; Signaling by BRAF and RAF1 fusions; Thrombin signalling through proteinase activated receptors (PARs); WNT5A-dependent internalization of FZD4; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "27" "0" "1.003" "0.938" "0.884" "0.956" "0.942" "0.967" "0.959" "0.959" "0.779" "753.4" "755.3" "706.9" "665.8" "720.0" "709.9" "728.6" "722.6" "722.7" "586.7" "" "" "" "" "" "" "" "" "" "" "677.3" "611.1" "639.4" "649.9" "594.2" "709.9" "545.5" "638.2" "646.7" "209.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3289616204838975461" "False" "High" "IsMasterProtein" "P62851" "Small ribosomal subunit protein eS25 OS=Homo sapiens OX=9606 GN=RPS25 PE=1 SV=1" "0.000" "False" "21.755" "37" "5" "16" "5" "125" "13.7" "10.11" "47.26" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf03297" "6230" "ENSG00000118181; ENSG00000280831" "RPS25" "B2R4M7; hsa:6230; P25111; P62851" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.956" "0.981" "0.888" "0.989" "1.036" "0.943" "0.971" "0.962" "1.003" "1840.5" "1759.0" "1805.9" "1634.6" "1821.1" "1907.2" "1735.4" "1786.6" "1770.4" "1846.0" "" "" "" "" "" "" "" "" "" "" "1654.8" "1423.3" "1633.5" "1595.6" "1502.8" "1907.2" "1299.4" "1578.0" "1584.1" "659.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1143391152356436137" "False" "High" "IsMasterProtein" "P62837" "Ubiquitin-conjugating enzyme E2 D2 OS=Homo sapiens OX=9606 GN=UBE2D2 PE=1 SV=1" "0.000" "False" "21.748" "41" "4" "8" "1" "147" "16.7" "7.83" "30.30" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7322" "ENSG00000131508" "UBE2D2" "D3DQC9; hsa:7322; P51669; P62837; Q3MN78; Q96RP6" "Proteasome degradation; Ciliary landscape" "FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; CLEC7A (Dectin-1) signaling; Neddylation; Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; IKK complex recruitment mediated by RIP1; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling" "16" "0" "1.037" "0.969" "1.015" "1.038" "0.934" "1.051" "1.041" "1.185" "0.787" "90.5" "93.8" "87.7" "91.9" "93.9" "84.5" "95.1" "94.2" "107.2" "71.2" "" "" "" "" "" "" "" "" "" "" "81.4" "75.9" "79.4" "89.7" "77.5" "84.5" "71.2" "83.2" "95.9" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6376451565471680516" "False" "High" "IsMasterProtein" "Q6P4I2" "WD repeat-containing protein 73 OS=Homo sapiens OX=9606 GN=WDR73 PE=1 SV=1" "0.000" "False" "21.744" "16" "6" "7" "6" "378" "41.7" "5.78" "21.45" "6" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "" "" "84942" "ENSG00000177082; ENSG00000291629" "WDR73" "hsa:84942; Q6P4I2; Q96JZ1; Q9P0B7" "Nephrotic syndrome; 15q25 copy number variation" "" "2" "0" "0.993" "0.974" "0.923" "1.000" "0.953" "0.933" "0.981" "1.003" "0.726" "455.7" "452.5" "443.7" "420.8" "455.9" "434.1" "425.4" "447.0" "457.2" "330.9" "" "" "" "" "" "" "" "" "" "" "409.7" "366.2" "401.3" "410.7" "376.2" "434.1" "318.5" "394.8" "409.1" "118.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7331601319371966852" "False" "High" "IsMasterProtein" "P21964" "Catechol O-methyltransferase OS=Homo sapiens OX=9606 GN=COMT PE=1 SV=2" "0.000" "False" "21.734" "25" "4" "5" "4" "271" "30.0" "5.47" "26.80" "4" "cell-cell signaling;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01596" "1312" "ENSG00000093010" "COMT" "A8MPV9; hsa:1312; P21964; Q6IB07; Q6ICE6; Q9BWC7" "Dopamine metabolism; Flavan-3-ol metabolic pathway; MTHFR deficiency; 22q11.2 copy number variation syndrome; Primary ovarian insufficiency; Biogenic amine synthesis; Estrogen metabolism; Metapathway biotransformation Phase I and II; Methylation pathways" "Potential therapeutics for SARS; Methylation; Enzymatic degradation of dopamine by COMT; Enzymatic degradation of Dopamine by monoamine oxidase" "13" "0" "0.995" "0.935" "1.036" "1.001" "0.981" "0.930" "0.943" "1.022" "0.912" "416.6" "414.4" "389.6" "431.7" "417.2" "408.5" "387.4" "392.8" "425.9" "379.9" "" "" "" "" "" "" "" "" "" "" "374.6" "335.3" "352.4" "421.4" "344.3" "408.5" "290.1" "347.0" "381.1" "135.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1047850882453787868" "False" "High" "IsMasterProtein" "Q96S19" "Methyltransferase-like 26 OS=Homo sapiens OX=9606 GN=METTL26 PE=1 SV=2" "0.000" "False" "21.729" "26" "6" "7" "6" "204" "22.6" "7.83" "25.77" "6" "" "" "other molecular function" "Pf06080" "84326" "ENSG00000130731" "METTL26" "A8MTR1; A8MWJ8; A8MZA1; B4DG95; B4DIJ3; D6REA6; F6TF62; F6VM53; hsa:84326; Q96IW1; Q96MD6; Q96S19" "" "" "0" "0" "1.121" "1.177" "1.002" "1.194" "1.065" "1.172" "1.066" "1.114" "1.107" "239.9" "269.0" "282.4" "240.3" "286.5" "255.5" "281.3" "255.9" "267.2" "265.5" "" "" "" "" "" "" "" "" "" "" "215.7" "217.7" "255.4" "234.6" "236.4" "255.5" "210.6" "226.0" "239.1" "94.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1553540605597619179" "False" "High" "IsMasterProtein" "P51965" "Ubiquitin-conjugating enzyme E2 E1 OS=Homo sapiens OX=9606 GN=UBE2E1 PE=1 SV=1" "0.000" "False" "21.710" "32" "5" "7" "2" "193" "21.4" "8.53" "24.87" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7324" "ENSG00000170142" "UBE2E1" "B2RBX4; C9J8K2; hsa:7324; K4DI90; P51965" "Photodynamic therapy-induced unfolded protein response; 7q11.23 copy number variation syndrome" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; ISG15 antiviral mechanism; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "23" "0" "1.008" "1.173" "1.196" "1.131" "1.104" "1.318" "1.168" "1.061" "1.567" "109.9" "110.8" "128.9" "131.5" "124.3" "121.4" "144.8" "128.3" "116.7" "172.3" "" "" "" "" "" "" "" "" "" "" "98.8" "89.7" "116.6" "128.3" "102.6" "121.4" "108.5" "113.3" "104.4" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7927368921331951811" "False" "High" "IsMasterProtein" "Cont_O46375" "Transthyretin OS=Bos taurus OX=9913 GN=TTR PE=1 SV=1" "0.000" "True" "21.705" "46" "5" "6" "5" "147" "15.7" "6.30" "23.00" "5" "other metabolic processes;signal transduction" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00576" "102267525; 104980319; 109577967; 280948" "ENSBGRG00000022634; ENSBIXG00000008920; ENSBIXG00005017301; ENSBTAG00000010991" "TTR" "A0A4W2BU20; A0A6B0QTW8; A0A6P3GKP7; A0A6P5DX06; A0A8B9YDR1; bbis:104980319; biu:109577967; bom:102267525; bta:280948; O46375; Q3SZ91" "" "Neutrophil degranulation; Retinoid metabolism and transport; The canonical retinoid cycle in rods (twilight vision)" "3" "0" "0.987" "0.937" "0.961" "0.899" "0.877" "0.945" "0.991" "0.909" "0.730" "396.5" "391.5" "371.3" "381.0" "356.5" "347.6" "374.7" "393.0" "360.4" "289.6" "" "" "" "" "" "" "" "" "" "" "356.5" "316.8" "335.9" "371.9" "294.2" "347.6" "280.6" "347.1" "322.4" "103.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013804065466167884" "False" "High" "IsMasterProtein" "Q3B7T1" "Erythroid differentiation-related factor 1 OS=Homo sapiens OX=9606 GN=EDRF1 PE=1 SV=1" "0.000" "False" "21.698" "7" "8" "9" "8" "1238" "138.4" "6.33" "26.71" "8" "other biological processes" "nucleus" "" "" "26098" "ENSG00000107938" "EDRF1" "B2RC65; hsa:26098; Q3B7T1; Q3KR40; Q4G190; Q5VZQ4; Q8IZ74; Q9Y3W4" "" "" "0" "0" "1.016" "1.063" "0.936" "0.949" "1.033" "1.017" "0.965" "1.015" "1.458" "272.1" "276.4" "289.3" "254.6" "258.3" "281.1" "276.6" "262.5" "276.1" "396.7" "" "" "" "" "" "" "" "" "" "" "244.6" "223.7" "261.7" "248.5" "213.2" "281.1" "207.1" "231.8" "247.1" "141.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901597498303011274" "False" "High" "IsMasterProtein" "P14621" "Acylphosphatase-2 OS=Homo sapiens OX=9606 GN=ACYP2 PE=1 SV=2" "0.000" "False" "21.695" "53" "6" "7" "6" "99" "11.1" "9.50" "26.03" "6" "other metabolic processes" "" "other molecular function" "Pf00708" "98" "ENSG00000170634" "ACYP2" "hsa:98; P14621" "" "" "0" "0" "0.906" "0.938" "0.909" "0.918" "0.865" "0.958" "0.931" "0.818" "0.702" "752.1" "681.2" "705.2" "683.3" "690.6" "650.8" "720.1" "700.5" "615.5" "527.8" "" "" "" "" "" "" "" "" "" "" "676.2" "551.2" "637.9" "667.0" "569.9" "650.8" "539.2" "618.7" "550.7" "188.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2025748717046247647" "False" "High" "IsMasterProtein" "Q8IV63" "Serine/threonine-protein kinase VRK3 OS=Homo sapiens OX=9606 GN=VRK3 PE=1 SV=2" "0.000" "False" "21.637" "14" "6" "6" "6" "474" "52.8" "9.04" "21.25" "6" "signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf13240" "51231" "ENSG00000105053" "VRK3" "A6NEG5; A8KA53; hsa:51231; Q502Y2; Q8IV63; Q9P2V8" "" "ERKs are inactivated" "1" "0" "1.003" "1.079" "0.932" "0.958" "1.013" "0.951" "0.900" "1.002" "0.693" "450.2" "451.5" "485.7" "419.6" "431.2" "456.0" "428.2" "405.3" "451.1" "312.2" "" "" "" "" "" "" "" "" "" "" "404.7" "365.4" "439.3" "409.6" "355.9" "456.0" "320.6" "358.0" "403.7" "111.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "575665869234459474" "False" "High" "IsMasterProtein" "P42331" "Rho GTPase-activating protein 25 OS=Homo sapiens OX=9606 GN=ARHGAP25 PE=1 SV=2" "0.000" "False" "21.633" "13" "9" "11" "9" "645" "73.4" "6.37" "29.49" "9" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane" "enzyme regulator activity" "Pf00169, Pf00620" "9938" "ENSG00000163219" "ARHGAP25" "A8K2Y1; B7Z498; E9PFQ7; G5E9G2; hsa:9938; P42331; Q8IXQ2" "" "RAC1 GTPase cycle" "1" "0" "1.016" "1.019" "0.999" "1.027" "0.995" "1.058" "0.964" "0.980" "2.718" "548.5" "557.4" "558.7" "547.9" "563.2" "545.6" "580.4" "528.8" "537.3" "1491.0" "" "" "" "" "" "" "" "" "" "" "493.2" "451.0" "505.4" "534.8" "464.7" "545.6" "434.6" "467.0" "480.8" "532.3" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3086265819139452668" "False" "High" "IsMasterProtein" "O14773" "Tripeptidyl-peptidase 1 OS=Homo sapiens OX=9606 GN=TPP1 PE=1 SV=2" "0.000" "False" "21.631" "12" "5" "7" "5" "563" "61.2" "6.48" "29.37" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00082, Pf09286" "1200" "ENSG00000166340" "TPP1" "hsa:1200; O14773; Q53HT1; Q5JAK6; Q6UX56; Q71JP6; Q96C37" "VEGFA-VEGFR2 signaling" "XBP1(S) activates chaperone genes" "2" "0" "1.055" "1.014" "0.999" "1.057" "1.121" "1.045" "1.102" "1.063" "1.093" "633.0" "667.8" "641.7" "632.2" "669.0" "709.3" "661.2" "697.8" "672.8" "691.9" "" "" "" "" "" "" "" "" "" "" "569.1" "540.3" "580.4" "617.1" "552.1" "709.3" "495.1" "616.3" "602.0" "247.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4536625609042411990" "False" "High" "IsMasterProtein" "Q16656" "Nuclear respiratory factor 1 OS=Homo sapiens OX=9606 GN=NRF1 PE=1 SV=1" "0.000" "False" "21.627" "14" "6" "7" "6" "503" "53.5" "5.05" "25.78" "6" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf10491" "4899" "ENSG00000106459" "NRF1" "A8K4C6; B4DDV6; hsa:4899; Q15305; Q16656; Q96AN2" "Energy metabolism; Interactions between LOXL4 and oxidative stress pathway; Mitochondrial gene expression; Sildenafil treatment" "PPARA activates gene expression; Transcriptional activation of mitochondrial biogenesis" "6" "0" "1.114" "1.005" "1.090" "1.172" "1.009" "1.101" "1.116" "0.953" "1.296" "141.6" "157.8" "142.4" "154.4" "166.0" "142.9" "155.9" "158.1" "135.0" "183.5" "" "" "" "" "" "" "" "" "" "" "127.4" "127.7" "128.8" "150.7" "137.0" "142.9" "116.7" "139.6" "120.8" "65.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3661455698439909776" "False" "High" "IsMasterProtein" "Q96AG4" "Leucine-rich repeat-containing protein 59 OS=Homo sapiens OX=9606 GN=LRRC59 PE=1 SV=1" "0.000" "False" "21.623" "23" "6" "7" "6" "307" "34.9" "9.57" "22.30" "6" "signal transduction" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "" "Pf13855" "55379" "ENSG00000108829" "LRRC59" "B2RE83; D3DTX8; hsa:55379; Q96AG4; Q9P189" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.887" "0.870" "0.997" "0.989" "0.945" "0.997" "0.989" "0.961" "0.601" "637.6" "565.8" "554.5" "635.5" "630.5" "602.8" "635.5" "630.8" "613.0" "383.2" "" "" "" "" "" "" "" "" "" "" "573.3" "457.8" "501.6" "620.4" "520.3" "602.8" "475.9" "557.2" "548.5" "136.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6585910940532122349" "False" "High" "IsMasterProtein" "Q5U5X0" "Complex III assembly factor LYRM7 OS=Homo sapiens OX=9606 GN=LYRM7 PE=1 SV=1" "0.000" "False" "21.610" "46" "4" "8" "4" "104" "11.9" "9.66" "30.08" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf05347" "90624" "ENSG00000186687" "LYRM7" "A8MPQ9; hsa:90624; Q5U5X0; Q86Y68" "Mitochondrial complex III assembly" "" "1" "0" "0.940" "1.092" "1.070" "1.049" "0.994" "1.063" "1.128" "1.197" "0.884" "521.9" "490.7" "570.1" "558.4" "547.7" "519.0" "555.0" "589.0" "624.9" "461.6" "" "" "" "" "" "" "" "" "" "" "469.3" "397.1" "515.6" "545.1" "452.0" "519.0" "415.6" "520.2" "559.2" "164.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611257715597886633" "False" "High" "IsMasterProtein" "Q15555" "Microtubule-associated protein RP/EB family member 2 OS=Homo sapiens OX=9606 GN=MAPRE2 PE=1 SV=1" "0.000" "False" "21.594" "27" "7" "8" "6" "327" "37.0" "5.57" "27.91" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "10982" "ENSG00000166974" "MAPRE2" "B2RE21; B3KR39; B4DJV4; B7Z2L3; E9PHR3; F5H1V8; G5E9I6; hsa:10982; Q15555; Q9UQ33" "Ciliary landscape" "" "1" "0" "0.925" "0.926" "1.000" "0.862" "0.902" "1.012" "0.788" "1.026" "9.292" "319.7" "295.9" "296.1" "319.7" "275.5" "288.5" "323.4" "251.9" "328.0" "2970.9" "" "" "" "" "" "" "" "" "" "" "287.4" "239.4" "267.9" "312.1" "227.4" "288.5" "242.1" "222.5" "293.5" "1060.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5735228591980069382" "False" "High" "IsMasterProtein" "Q9HD42" "Charged multivesicular body protein 1a OS=Homo sapiens OX=9606 GN=CHMP1A PE=1 SV=1" "0.000" "False" "21.588" "24" "7" "10" "7" "196" "21.7" "8.06" "27.19" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "5119" "ENSG00000131165" "CHMP1A" "A2RU09; hsa:5119; Q14468; Q15779; Q96G31; Q9HD42" "" "HCMV Late Events" "1" "0" "0.954" "1.043" "0.907" "1.004" "1.022" "1.079" "1.060" "1.015" "0.852" "1221.1" "1165.5" "1273.2" "1107.2" "1226.0" "1247.8" "1318.1" "1294.5" "1239.5" "1040.4" "" "" "" "" "" "" "" "" "" "" "1097.9" "943.1" "1151.6" "1080.8" "1011.7" "1247.8" "987.0" "1143.4" "1109.1" "371.4" "8" "8" "8" "8" "8" "8" "8" "8" "8" "8" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3133917976218081073" "False" "High" "IsMasterProtein" "Q9Y3D8" "Adenylate kinase isoenzyme 6 OS=Homo sapiens OX=9606 GN=AK6 PE=1 SV=1" "0.000" "False" "21.587" "37" "5" "7" "5" "172" "20.0" "4.58" "27.31" "5" "other metabolic processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf13238" "102157402" "ENSG00000085231; ENSG00000279247" "AK6" "A8MSZ6; hsa:102157402; Q5F2S9; Q9Y3D8" "" "Interconversion of nucleotide di- and triphosphates" "1" "0" "1.034" "1.016" "1.068" "1.064" "1.155" "1.003" "1.028" "1.055" "2.397" "139.5" "144.2" "141.7" "148.9" "148.4" "161.2" "139.9" "143.4" "147.1" "334.5" "" "" "" "" "" "" "" "" "" "" "125.4" "116.7" "128.2" "145.4" "122.4" "161.2" "104.8" "126.7" "131.6" "119.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3011217780081752783" "False" "High" "IsMasterProtein" "O43164" "E3 ubiquitin-protein ligase Praja-2 OS=Homo sapiens OX=9606 GN=PJA2 PE=1 SV=4" "0.000" "False" "21.579" "11" "5" "8" "5" "708" "78.2" "4.39" "23.69" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf13639" "9867" "ENSG00000198961" "PJA2" "A8K6U4; D3DSZ5; O43164; Q68D49; Q8N1G5" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.083" "1.040" "0.972" "1.004" "1.082" "0.934" "0.973" "1.067" "1.070" "119.5" "129.4" "124.3" "116.1" "119.9" "129.3" "111.6" "116.3" "127.5" "127.8" "" "" "" "" "" "" "" "" "" "" "107.4" "104.7" "112.4" "113.4" "99.0" "129.3" "83.5" "102.7" "114.1" "45.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6425786624467733847" "False" "High" "IsMasterProtein" "O95758" "Polypyrimidine tract-binding protein 3 OS=Homo sapiens OX=9606 GN=PTBP3 PE=1 SV=2" "0.000" "False" "21.559" "8" "5" "21" "2" "552" "59.7" "9.04" "64.03" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf11835, Pf13893" "9991" "ENSG00000119314" "PTBP3" "B1ALY2; B1ALY3; B1ALY5; B1ALY6; B3KME7; hsa:9991; O95758; Q68DB9; Q86YB3; Q86YH9" "" "" "0" "0" "0.849" "1.204" "1.003" "1.002" "0.758" "1.031" "0.791" "0.750" "5.892" "57.3" "48.7" "69.0" "57.5" "57.5" "43.4" "59.1" "45.3" "43.0" "337.7" "" "" "" "" "" "" "" "" "" "" "51.5" "39.4" "62.4" "56.1" "47.4" "43.4" "44.3" "40.1" "38.5" "120.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3245672403803654152" "False" "High" "IsMasterProtein" "P62263" "Small ribosomal subunit protein uS11 OS=Homo sapiens OX=9606 GN=RPS14 PE=1 SV=3" "0.000" "False" "21.557" "30" "4" "7" "4" "151" "16.3" "10.05" "34.59" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00411" "6208" "ENSG00000164587" "RPS14" "B2R5G5; D3DQG5; hsa:6208; P06366; P62263; Q5BJI0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; rRNA modification in the nucleus and cytosol; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "20" "0" "1.079" "1.051" "0.980" "1.100" "1.128" "1.187" "1.071" "1.082" "1.550" "398.1" "429.4" "418.3" "390.2" "438.0" "449.1" "472.5" "426.3" "430.8" "616.9" "" "" "" "" "" "" "" "" "" "" "357.9" "347.4" "378.3" "380.9" "361.5" "449.1" "353.8" "376.5" "385.5" "220.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "244400377751924858" "False" "High" "IsMasterProtein" "Q9HCE0" "Ectopic P granules protein 5 homolog OS=Homo sapiens OX=9606 GN=EPG5 PE=1 SV=2" "0.000" "False" "21.551" "3" "7" "8" "7" "2579" "292.3" "6.43" "25.98" "7" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other cytoplasmic organelle;other cell component" "" "" "57724" "ENSG00000152223" "EPG5" "A2BDF3; hsa:57724; Q9H8C8; Q9HCE0" "" "" "0" "0" "0.905" "1.038" "0.959" "1.014" "0.889" "1.049" "0.894" "1.068" "0.973" "102.2" "92.5" "106.1" "98.0" "103.6" "90.9" "107.2" "91.4" "109.1" "99.4" "" "" "" "" "" "" "" "" "" "" "91.9" "74.9" "96.0" "95.7" "85.5" "90.9" "80.3" "80.7" "97.6" "35.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4134532342981628088" "False" "High" "IsMasterProtein" "Q9BSV6" "tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens OX=9606 GN=TSEN34 PE=1 SV=1" "0.000" "False" "21.523" "24" "6" "7" "6" "310" "33.6" "8.43" "22.52" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01974" "79042" "ENSG00000170892; ENSG00000273896; ENSG00000274078; ENSG00000274129; ENSG00000274672; ENSG00000274796; ENSG00000275165; ENSG00000278605; ENSG00000278622; ENSG00000278712" "TSEN34" "A6NNB1; B0V3J1; hsa:79042; Q9BSV6; Q9BVT1; Q9H6H5" "" "tRNA processing in the nucleus" "1" "0" "1.027" "0.962" "1.047" "1.012" "1.000" "1.047" "1.018" "1.005" "1.113" "388.4" "398.8" "373.7" "406.7" "392.9" "388.3" "406.8" "395.3" "390.2" "432.4" "" "" "" "" "" "" "" "" "" "" "349.2" "322.7" "338.0" "397.0" "324.2" "388.3" "304.6" "349.2" "349.1" "154.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5299330729239778052" "False" "High" "IsMasterProtein" "Q6PFW1" "Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=PPIP5K1 PE=1 SV=1" "0.000" "False" "21.512" "5" "7" "8" "1" "1433" "159.4" "5.40" "28.57" "7" "other metabolic processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00328, Pf18086" "9677" "ENSG00000168781" "PPIP5K1" "hsa:9677; O15082; Q5HYF8; Q6PFW1; Q7Z3A7; Q86TE7; Q86UV3; Q86UV4; Q86XW8; Q8IZN0" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4037115124737055274" "False" "High" "IsMasterProtein" "P04439" "HLA class I histocompatibility antigen, A alpha chain OS=Homo sapiens OX=9606 GN=HLA-A PE=1 SV=2" "0.000" "False" "21.511" "16" "4" "5" "2" "365" "40.8" "6.00" "21.38" "4" "stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3105" "ENSG00000206503" "HLA-A" "B1PKZ3; hsa:3105; O02939; O02954; O02955; O02963; O19509; O19546; O19598; O19605; O19606; O19619; O19647; O19673; O19687; O19695; O19756; O19794; O19795; O43906; O43907; O46874; O62921; O62924; O77937; O77938; O77964; O78073; O78171; O98009; O98010; O98011; O98137; P01891; P01892; P04439; P05534; P06338; P10313; P10314; P10315; P10316; P13746; P16188; P16189; P16190; P18462; P30443; P30444; P30445; P30446; P30447; P30448; P30449; P30450; P30451; P30452; P30453; P30454; P30455; P30456; P30457; P30458; P30459; P30512; P30514; P79505; P79562; P79563; Q09160; Q29680; Q29747; Q29835; Q29837; Q29838; Q29899; Q29908; Q29909; Q29910; Q30208; Q31623; Q5S3G1; Q65A82; Q8MHM1; Q8MHN9; Q95352; Q95355; Q95362; Q95377; Q95380; Q95IZ5; Q9BCN0; Q9BD15; Q9BD19; Q9GJE6; Q9GJE7; Q9GJE8; Q9MW42; Q9MY89; Q9MYA3; Q9MYA5; Q9MYC4; Q9MYE6; Q9MYE9; Q9MYG4; Q9MYG5; Q9MYI5; Q9TP25; Q9TPQ3; Q9TPR8; Q9TPX8; Q9TPX9; Q9TPY0; Q9TQ24; Q9TQE8; Q9TQE9; Q9TQF1; Q9TQF5; Q9TQF8; Q9TQF9; Q9TQG0; Q9TQG5; Q9TQG7; Q9TQH5; Q9TQI3; Q9TQK5; Q9TQM6; Q9TQN5; Q9TQP5; Q9TQP6; Q9TQP7; Q9UIN1; Q9UIN2; Q9UIP7; Q9UQU3; Q9UQU6; Q9UQU7" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; Cancer immunotherapy by PD-1 blockade; TAR syndrome" "ER-Phagosome pathway; Nef mediated downregulation of MHC class I complex cell surface expression; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; E3 ubiquitin ligases ubiquitinate target proteins; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon gamma signaling; Interferon alpha/beta signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "14" "0" "1.071" "1.087" "0.897" "1.055" "1.180" "1.021" "1.047" "1.153" "0.896" "251.9" "269.8" "273.9" "226.0" "265.6" "297.3" "257.1" "263.7" "290.5" "225.7" "" "" "" "" "" "" "" "" "" "" "226.5" "218.3" "247.8" "220.7" "219.2" "297.3" "192.5" "232.9" "260.0" "80.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6395049123037932349" "False" "High" "IsMasterProtein" "P30793" "GTP cyclohydrolase 1 OS=Homo sapiens OX=9606 GN=GCH1 PE=1 SV=1" "0.000" "False" "21.499" "28" "7" "8" "7" "250" "27.9" "8.56" "27.63" "7" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01227" "2643" "ENSG00000131979" "GCH1" "hsa:2643; P30793; Q6FHY7; Q9Y4I8" "Ferroptosis" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "2" "0" "0.967" "1.169" "0.983" "0.970" "1.160" "0.968" "1.004" "1.240" "0.960" "862.3" "833.5" "1008.0" "847.5" "836.3" "1000.1" "834.8" "865.9" "1069.6" "828.0" "" "" "" "" "" "" "" "" "" "" "775.3" "674.4" "911.8" "827.3" "690.1" "1000.1" "625.1" "764.9" "957.1" "295.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012550924560015135" "False" "High" "IsMasterProtein" "O43805" "Microtubule nucleation factor SSNA1 OS=Homo sapiens OX=9606 GN=SSNA1 PE=1 SV=2" "0.000" "False" "21.480" "39" "5" "10" "5" "119" "13.6" "5.38" "38.83" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "8636" "ENSG00000176101" "SSNA1" "hsa:8636; O43805; Q5VSG0; Q6FG70; Q9BVW8" "Ciliary landscape" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.004" "0.923" "1.073" "1.000" "1.060" "1.034" "1.072" "1.013" "0.889" "582.2" "584.5" "537.2" "624.4" "581.9" "617.2" "602.2" "624.0" "589.5" "517.8" "" "" "" "" "" "" "" "" "" "" "523.4" "473.0" "485.9" "609.5" "480.2" "617.2" "450.9" "551.2" "527.5" "184.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5416177737731563011" "False" "High" "IsMasterProtein" "Q14457" "Beclin-1 OS=Homo sapiens OX=9606 GN=BECN1 PE=1 SV=2" "0.000" "False" "21.468" "15" "7" "8" "7" "450" "51.9" "4.89" "26.95" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04111, Pf15285, Pf17675" "8678" "ENSG00000126581" "BECN1" "B2R6N7; hsa:8678; O75595; Q14457; Q9UNA8" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; 7q11.23 copy number variation syndrome; Pleural mesothelioma; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; Autophagy in pancreatic ductal adenocarcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy; RSV-host interactions; Ub-specific processing proteases; ISG15 antiviral mechanism; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "18" "0" "0.988" "0.955" "0.953" "1.032" "1.014" "1.016" "0.974" "0.987" "0.936" "463.2" "457.4" "442.5" "441.5" "478.0" "469.6" "470.4" "451.3" "457.2" "433.5" "" "" "" "" "" "" "" "" "" "" "416.4" "370.1" "400.3" "431.0" "394.5" "469.6" "352.2" "398.6" "409.1" "154.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2337830748365545884" "False" "High" "IsMasterProtein" "Q53FT3" "Protein Hikeshi OS=Homo sapiens OX=9606 GN=HIKESHI PE=1 SV=2" "0.000" "False" "21.452" "19" "4" "9" "4" "197" "21.6" "5.45" "33.11" "4" "cell organization and biogenesis;stress response;transport;developmental processes" "cytosol;nucleus" "other molecular function" "Pf05603, Pf21057" "51501" "ENSG00000149196" "HIKESHI" "hsa:51501; Q53FT3; Q8WVE8; Q9NVQ2; Q9NZZ1; Q9P022; Q9P0N1" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.006" "1.009" "0.940" "1.052" "0.904" "1.014" "1.028" "0.988" "0.753" "986.5" "992.4" "995.2" "927.4" "1037.6" "891.4" "1000.3" "1014.0" "974.4" "743.0" "" "" "" "" "" "" "" "" "" "" "886.9" "803.0" "900.2" "905.3" "856.2" "891.4" "749.0" "895.6" "871.9" "265.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5199956621996248182" "False" "High" "IsMasterProtein" "P18859" "ATP synthase-coupling factor 6, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PF PE=1 SV=1" "0.000" "False" "21.441" "38" "3" "6" "3" "108" "12.6" "9.52" "30.81" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05511" "522" "ENSG00000154723" "ATP5PF" "hsa:522; J3KQ83; P18859" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.844" "0.964" "0.923" "0.950" "0.991" "0.867" "0.954" "0.968" "0.532" "494.7" "417.6" "477.0" "456.7" "470.1" "490.3" "428.7" "472.0" "478.7" "263.2" "" "" "" "" "" "" "" "" "" "" "444.8" "337.9" "431.4" "445.8" "387.9" "490.3" "321.0" "416.9" "428.3" "93.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7638543548033193713" "False" "High" "IsMasterProtein" "Q00765" "Receptor expression-enhancing protein 5 OS=Homo sapiens OX=9606 GN=REEP5 PE=1 SV=3" "0.000" "False" "21.433" "20" "4" "7" "4" "189" "21.5" "8.10" "25.00" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "" "Pf03134" "7905" "ENSG00000129625" "REEP5" "B7Z681; D3DT04; hsa:7905; Q00765; Q04198; Q5QGT0; Q9BWH9" "" "" "0" "0" "1.047" "1.006" "1.002" "1.036" "1.089" "1.029" "1.045" "0.910" "0.895" "446.2" "467.1" "449.0" "447.3" "462.2" "486.0" "459.4" "466.4" "406.0" "399.6" "" "" "" "" "" "" "" "" "" "" "401.2" "377.9" "406.2" "436.6" "381.4" "486.0" "344.0" "411.9" "363.3" "142.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246556582121742605" "False" "High" "IsMasterProtein" "Q9P253" "Vacuolar protein sorting-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=VPS18 PE=1 SV=2" "0.000" "False" "21.424" "8" "8" "10" "8" "973" "110.1" "6.07" "33.13" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf05131" "57617" "ENSG00000104142" "VPS18" "hsa:57617; Q8TCG0; Q96DI3; Q9H268; Q9P253" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "3" "0" "1.064" "1.042" "0.960" "1.079" "1.006" "1.047" "0.906" "1.014" "1.294" "413.2" "439.7" "430.4" "396.6" "445.9" "415.6" "432.5" "374.2" "418.9" "534.9" "" "" "" "" "" "" "" "" "" "" "371.5" "355.8" "389.3" "387.1" "367.9" "415.6" "323.8" "330.5" "374.9" "190.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5758316461638693187" "False" "High" "IsMasterProtein" "Q05519" "Serine/arginine-rich splicing factor 11 OS=Homo sapiens OX=9606 GN=SRSF11 PE=1 SV=1" "0.000" "False" "21.402" "13" "6" "7" "6" "484" "53.5" "10.52" "19.61" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00076" "9295" "ENSG00000116754" "SRSF11" "hsa:9295; Q05519; Q5T758; Q8IWE6" "" "mRNA Splicing - Major Pathway; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "0.936" "0.960" "0.957" "0.892" "1.003" "1.013" "0.932" "0.925" "0.949" "392.9" "367.8" "377.2" "376.0" "350.3" "394.0" "397.9" "366.1" "363.5" "373.0" "" "" "" "" "" "" "" "" "" "" "353.3" "297.6" "341.1" "367.0" "289.1" "394.0" "297.9" "323.3" "325.3" "133.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5558821625919889641" "False" "High" "IsMasterProtein" "Q9UDY4" "DnaJ homolog subfamily B member 4 OS=Homo sapiens OX=9606 GN=DNAJB4 PE=1 SV=1" "0.000" "False" "21.397" "17" "5" "6" "4" "337" "37.8" "8.50" "21.51" "5" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00226, Pf01556" "11080" "ENSG00000162616" "DNAJB4" "B2R824; hsa:11080; Q13431; Q9UDY4" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.998" "1.266" "0.974" "0.983" "1.257" "1.170" "1.003" "1.162" "1.010" "230.1" "229.8" "291.3" "224.2" "226.1" "289.2" "269.2" "230.7" "267.4" "232.5" "" "" "" "" "" "" "" "" "" "" "206.9" "185.9" "263.5" "218.8" "186.6" "289.2" "201.6" "203.8" "239.3" "83.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1329067276742603011" "False" "High" "IsMasterProtein" "Q8WYP5" "Protein ELYS OS=Homo sapiens OX=9606 GN=AHCTF1 PE=1 SV=3" "0.000" "False" "21.378" "3" "4" "6" "4" "2266" "252.3" "6.60" "27.62" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf13934, Pf16687" "25909" "ENSG00000153207" "AHCTF1" "A6NGM0; A8MSG9; A8MZ86; hsa:25909; Q7Z4E3; Q8IZA4; Q8WYP5; Q96EH9; Q9Y4Q6" "Gastric cancer network 2" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Postmitotic nuclear pore complex (NPC) reformation" "8" "0" "0.976" "0.961" "0.965" "1.023" "1.021" "0.825" "0.898" "1.070" "0.793" "287.9" "280.9" "276.6" "277.8" "294.4" "293.9" "237.5" "258.6" "307.9" "228.4" "" "" "" "" "" "" "" "" "" "" "258.9" "227.3" "250.2" "271.2" "242.9" "293.9" "177.9" "228.4" "275.5" "81.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3902641514385650329" "False" "High" "IsMasterProtein" "Q5BKZ1" "DBIRD complex subunit ZNF326 OS=Homo sapiens OX=9606 GN=ZNF326 PE=1 SV=2" "0.000" "False" "21.355" "14" "6" "6" "6" "582" "65.6" "5.15" "23.47" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04988" "284695" "ENSG00000162664" "ZNF326" "A8MYX1; B4DLN0; B4E179; hsa:284695; Q5BKZ1; Q5VW93; Q5VW94; Q5VW96; Q5VW97; Q6NSA2; Q7Z638; Q7Z6C2" "" "" "0" "0" "0.889" "0.787" "0.931" "0.920" "0.848" "0.992" "0.867" "0.817" "3.739" "446.2" "396.7" "351.1" "415.5" "410.4" "378.1" "442.8" "387.0" "364.5" "1668.2" "" "" "" "" "" "" "" "" "" "" "401.2" "321.0" "317.6" "405.6" "338.7" "378.1" "331.5" "341.8" "326.1" "595.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3187719389386559931" "False" "High" "IsMasterProtein" "Q9Y2V2" "Calcium-regulated heat-stable protein 1 OS=Homo sapiens OX=9606 GN=CARHSP1 PE=1 SV=2" "0.000" "False" "21.350" "34" "6" "15" "6" "147" "15.9" "8.21" "48.48" "6" "signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00313" "23589" "ENSG00000153048" "CARHSP1" "B2R4C3; D3DUF5; hsa:23589; Q2YDX5; Q9BQ53; Q9Y2V2" "" "" "0" "0" "0.951" "1.004" "0.971" "0.977" "0.896" "0.976" "1.027" "0.969" "0.760" "1126.9" "1072.2" "1131.9" "1094.3" "1101.0" "1009.2" "1100.0" "1157.0" "1091.7" "855.9" "" "" "" "" "" "" "" "" "" "" "1013.2" "867.6" "1023.9" "1068.2" "908.5" "1009.2" "823.6" "1022.0" "976.9" "305.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "469142345215753577" "False" "High" "IsMasterProtein" "Q9Y2R9" "Small ribosomal subunit protein uS7m OS=Homo sapiens OX=9606 GN=MRPS7 PE=1 SV=2" "0.000" "False" "21.338" "28" "6" "8" "6" "242" "28.1" "9.99" "31.84" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00177" "51081" "ENSG00000125445" "MRPS7" "B2R9N5; hsa:51081; Q53GD6; Q9Y2R9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.954" "0.976" "0.924" "0.972" "0.935" "1.061" "0.977" "0.911" "1.332" "673.3" "642.3" "656.9" "622.1" "654.7" "629.6" "714.2" "657.9" "613.5" "896.5" "" "" "" "" "" "" "" "" "" "" "605.3" "519.8" "594.2" "607.3" "540.3" "629.6" "534.7" "581.1" "548.9" "320.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1246838135834817893" "False" "High" "IsMasterProtein" "O75362" "Zinc finger protein 217 OS=Homo sapiens OX=9606 GN=ZNF217 PE=1 SV=1" "0.000" "False" "21.319" "7" "6" "9" "6" "1048" "115.2" "8.48" "25.09" "6" "other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7764" "ENSG00000171940" "ZNF217" "E1P5Y6; hsa:7764; O75362; Q14DB8" "" "Estrogen-dependent gene expression" "1" "0" "0.971" "0.958" "0.950" "0.964" "0.905" "1.158" "0.971" "0.915" "0.959" "973.2" "944.6" "932.6" "924.8" "938.5" "880.6" "1126.5" "944.5" "890.0" "933.6" "" "" "" "" "" "" "" "" "" "" "875.0" "764.4" "843.6" "902.7" "774.5" "880.6" "843.5" "834.3" "796.4" "333.3" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6364343737777032179" "False" "High" "IsMasterProtein" "P08754" "Guanine nucleotide-binding protein G(i) subunit alpha-3 OS=Homo sapiens OX=9606 GN=GNAI3 PE=1 SV=3" "0.000" "False" "21.297" "14" "5" "7" "2" "354" "40.5" "5.69" "21.05" "5" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00503" "2773" "ENSG00000065135" "GNAI3" "hsa:2773; P08754; P17539; Q5TZX1" "Thyroid stimulating hormone (TSH) signaling pathway; S1P receptor signal transduction; Complement system; G protein signaling pathways; Chemokine signaling pathway; Hippo signaling regulation pathways; Purinergic signaling; Calcium regulation in cardiac cells; 5q35 copy number variation; Serotonin HTR1 group and FOS pathway" "G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production" "18" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516150800733119915" "False" "High" "IsMasterProtein" "P55011" "Solute carrier family 12 member 2 OS=Homo sapiens OX=9606 GN=SLC12A2 PE=1 SV=1" "0.000" "False" "21.238" "7" "5" "6" "5" "1212" "131.4" "6.40" "26.56" "5" "cell-cell signaling;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00324, Pf03522, Pf08403" "6558" "ENSG00000064651" "SLC12A2" "hsa:6558; P55011; Q8N713; Q8WWH7" "Polycystic kidney disease pathway" "Cation-coupled Chloride cotransporters" "2" "0" "0.897" "0.882" "0.942" "0.953" "0.981" "1.053" "1.023" "0.934" "0.736" "360.8" "323.5" "318.1" "340.0" "343.9" "353.8" "379.8" "369.1" "336.9" "265.6" "" "" "" "" "" "" "" "" "" "" "324.4" "261.8" "287.7" "331.9" "283.8" "353.8" "284.4" "326.0" "301.5" "94.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3178523695898665962" "False" "High" "IsMasterProtein" "Q9NYF8" "Bcl-2-associated transcription factor 1 OS=Homo sapiens OX=9606 GN=BCLAF1 PE=1 SV=2" "0.000" "False" "21.234" "8" "8" "8" "7" "920" "106.1" "9.98" "24.67" "8" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15440" "9774" "ENSG00000029363" "BCLAF1" "A2RU75; B7ZM58; E1P586; hsa:9774; Q14673; Q86WU6; Q86WY0; Q9NYF8" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "0.993" "1.071" "0.909" "1.092" "1.100" "1.087" "1.071" "0.928" "1.054" "568.2" "563.9" "608.7" "516.2" "620.6" "625.2" "617.5" "608.5" "527.3" "598.9" "" "" "" "" "" "" "" "" "" "" "510.8" "456.3" "550.6" "503.9" "512.1" "625.2" "462.4" "537.5" "471.8" "213.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4535495802418594220" "False" "High" "IsMasterProtein" "Q9H081" "Protein MIS12 homolog OS=Homo sapiens OX=9606 GN=MIS12 PE=1 SV=1" "0.000" "False" "21.225" "35" "6" "6" "6" "205" "24.1" "5.69" "25.42" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf05859" "79003" "ENSG00000167842" "MIS12" "hsa:79003; Q96N24; Q9H081" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.960" "1.006" "0.944" "1.003" "1.069" "1.035" "0.941" "1.027" "0.886" "363.1" "348.5" "365.2" "342.8" "364.3" "388.3" "376.0" "341.6" "373.1" "321.7" "" "" "" "" "" "" "" "" "" "" "326.5" "282.0" "330.3" "334.6" "300.6" "388.3" "281.5" "301.8" "333.8" "114.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2951655110054191757" "False" "High" "IsMasterProtein" "Q5VW32" "BRO1 domain-containing protein BROX OS=Homo sapiens OX=9606 GN=BROX PE=1 SV=1" "0.000" "False" "21.154" "17" "6" "7" "6" "411" "46.4" "7.65" "25.45" "6" "cell cycle OR cell proliferation;cell organization and biogenesis" "other membranes;nucleus" "" "Pf03097" "148362" "ENSG00000162819" "BROX" "B7Z9G5; hsa:148362; Q5VW32; Q96MG1" "" "" "0" "0" "1.060" "0.935" "1.050" "1.058" "0.960" "1.023" "0.983" "0.981" "0.835" "596.6" "632.6" "558.0" "626.1" "631.2" "572.7" "610.0" "586.4" "585.4" "498.2" "" "" "" "" "" "" "" "" "" "" "536.4" "511.8" "504.8" "611.2" "520.8" "572.7" "456.8" "517.9" "523.8" "177.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8837747805973553035" "False" "High" "IsMasterProtein" "Q12778" "Forkhead box protein O1 OS=Homo sapiens OX=9606 GN=FOXO1 PE=1 SV=2" "0.000" "False" "21.114" "11" "6" "6" "6" "655" "69.6" "6.77" "20.79" "6" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf16675, Pf16676" "2308" "ENSG00000150907" "FOXO1" "hsa:2308; O43523; Q12778; Q5VYC7; Q6NSK6" "Androgen receptor signaling pathway; Energy metabolism; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Adipogenesis; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Copper homeostasis; Melatonin metabolism and effects; RAC1/PAK1/p38/MMP2 pathway; Transcription factor regulation in adipogenesis; NAD metabolism, sirtuins and aging; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; White fat cell differentiation; Somatroph axis (GH) and its relationship to dietary restriction and aging; EGF/EGFR signaling pathway; Leukocyte-intrinsic Hippo pathway functions; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; Kynurenine pathway and links to cell senescence; FOXA2 pathway; Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Warburg effect modulated by deubiquitinating enzymes and their substrates; Extrafollicular and follicular B cell activation by SARS-CoV-2; Primary ovarian insufficiency; Rubinstein-Taybi syndrome 1; ErbB signaling pathway" "Constitutive Signaling by AKT1 E17K in Cancer; MAPK6/MAPK4 signaling; AKT phosphorylates targets in the nucleus; Regulation of localization of FOXO transcription factors; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Interleukin-4 and Interleukin-13 signaling; FOXO-mediated transcription of cell cycle genes; FOXO-mediated transcription of cell death genes; Regulation of FOXO transcriptional activity by acetylation; AKT-mediated inactivation of FOXO1A" "52" "0" "0.955" "0.905" "1.053" "1.171" "0.914" "1.114" "1.036" "1.011" "1.929" "339.1" "323.8" "307.0" "357.1" "397.0" "310.0" "377.7" "351.5" "342.9" "654.3" "" "" "" "" "" "" "" "" "" "" "304.9" "262.0" "277.7" "348.5" "327.6" "310.0" "282.8" "310.5" "306.8" "233.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7486403724056782188" "False" "High" "IsMasterProtein" "Q7L8L6" "FAST kinase domain-containing protein 5, mitochondrial OS=Homo sapiens OX=9606 GN=FASTKD5 PE=1 SV=1" "0.000" "False" "21.077" "10" "8" "9" "8" "764" "86.5" "8.13" "28.14" "8" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "nucleic acid binding activity" "Pf06743, Pf08368, Pf08373" "60493" "ENSG00000215251" "FASTKD5" "hsa:60493; Q7L8L6; Q96JN3; Q9H5D1; Q9H8Y3" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.012" "1.047" "0.967" "1.092" "0.979" "1.017" "1.032" "0.999" "1.808" "364.0" "368.5" "381.2" "351.9" "397.7" "356.3" "370.3" "375.8" "363.7" "658.1" "" "" "" "" "" "" "" "" "" "" "327.3" "298.2" "344.8" "343.5" "328.2" "356.3" "277.3" "331.9" "325.5" "234.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686593457953999194" "False" "High" "IsMasterProtein" "P45985" "Dual specificity mitogen-activated protein kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP2K4 PE=1 SV=1" "0.000" "False" "21.072" "20" "8" "9" "8" "399" "44.3" "8.07" "29.71" "8" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "6416" "ENSG00000065559" "MAP2K4" "B2R7N7; B3KYB2; D3DTS5; hsa:6416; P45985; Q5U0B8; Q6FHX4; Q6P9H2; Q6PIE6" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; Glioblastoma signaling pathways; TNF-alpha signaling pathway; PDGF pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Oxidative damage response; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; MAPK cascade; Epithelial to mesenchymal transition in colorectal cancer; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "35" "0" "0.991" "0.930" "0.935" "1.064" "1.043" "1.021" "1.013" "1.045" "0.825" "737.3" "731.0" "685.9" "689.0" "784.7" "768.8" "752.8" "746.9" "770.2" "608.4" "" "" "" "" "" "" "" "" "" "" "662.9" "591.5" "620.4" "672.6" "647.6" "768.8" "563.7" "659.7" "689.1" "217.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2401659008786487723" "False" "High" "IsMasterProtein" "Q5VZF2" "Muscleblind-like protein 2 OS=Homo sapiens OX=9606 GN=MBNL2 PE=1 SV=2" "0.000" "False" "21.068" "11" "5" "10" "1" "373" "40.5" "8.38" "36.56" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "10150" "ENSG00000139793" "MBNL2" "hsa:10150; Q3SXY5; Q58F19; Q5VZF2; Q8NEV3; Q8TD82" "" "" "0" "0" "0.894" "0.881" "0.958" "0.985" "0.938" "1.043" "1.016" "1.020" "1.206" "142.8" "127.6" "125.8" "136.9" "140.7" "134.0" "149.0" "145.1" "145.7" "172.3" "" "" "" "" "" "" "" "" "" "" "128.4" "103.3" "113.8" "133.6" "116.1" "134.0" "111.6" "128.1" "130.4" "61.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3480687027944615342" "False" "High" "IsMasterProtein" "Q8NHG8" "E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens OX=9606 GN=ZNRF2 PE=1 SV=1" "0.000" "False" "21.062" "24" "4" "5" "4" "242" "24.1" "7.09" "24.24" "4" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13639" "223082" "ENSG00000180233" "ZNRF2" "Q8NHG8" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.934" "0.873" "0.974" "1.029" "0.963" "0.991" "0.968" "0.958" "0.808" "219.9" "205.3" "191.9" "214.1" "226.3" "211.8" "217.8" "212.9" "210.6" "177.7" "" "" "" "" "" "" "" "" "" "" "197.7" "166.1" "173.6" "209.0" "186.8" "211.8" "163.1" "188.0" "188.5" "63.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3877552904475964910" "False" "High" "IsMasterProtein" "Q9NX63" "MICOS complex subunit MIC19 OS=Homo sapiens OX=9606 GN=CHCHD3 PE=1 SV=1" "0.000" "False" "20.997" "26" "6" "8" "6" "227" "26.1" "8.28" "19.22" "6" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf05300" "54927" "ENSG00000106554" "CHCHD3" "hsa:54927; Q9NX63" "" "Mitochondrial protein import; Cristae formation" "2" "0" "1.041" "0.976" "0.968" "1.034" "1.005" "1.096" "1.079" "0.952" "0.466" "811.3" "844.2" "792.1" "785.1" "838.9" "815.6" "889.5" "875.4" "772.7" "378.3" "" "" "" "" "" "" "" "" "" "" "729.5" "683.1" "716.5" "766.4" "692.3" "815.6" "666.1" "773.2" "691.4" "135.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1907773996049463670" "False" "High" "IsMasterProtein" "O43504" "Ragulator complex protein LAMTOR5 OS=Homo sapiens OX=9606 GN=LAMTOR5 PE=1 SV=1" "0.000" "False" "20.963" "55" "3" "6" "3" "91" "9.6" "4.87" "31.56" "3" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf16672" "10542" "ENSG00000134248" "LAMTOR5" "A0A0C4DGV4; hsa:10542; O43504; Q6IBD8" "" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "0.970" "1.068" "1.038" "1.143" "1.142" "1.122" "1.148" "1.171" "0.875" "600.2" "582.0" "640.9" "622.7" "685.9" "685.4" "673.5" "688.9" "702.7" "525.0" "" "" "" "" "" "" "" "" "" "" "539.6" "471.0" "579.8" "607.8" "566.0" "685.4" "504.3" "608.5" "628.8" "187.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5322570357493023656" "False" "High" "IsMasterProtein" "Q8IUQ0" "Clavesin-1 OS=Homo sapiens OX=9606 GN=CLVS1 PE=1 SV=1" "0.000" "False" "20.962" "22" "6" "6" "6" "354" "40.8" "7.20" "23.86" "6" "cell organization and biogenesis" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00650, Pf03765" "157807" "ENSG00000177182" "CLVS1" "B2R7M5; C8UZT3; Q8IUQ0; Q8NB32" "Ectoderm differentiation" "Lysosome Vesicle Biogenesis" "2" "0" "1.074" "1.031" "0.952" "1.152" "0.936" "1.126" "0.978" "0.939" "0.860" "329.9" "354.4" "340.1" "314.2" "380.0" "308.9" "371.5" "322.7" "309.9" "283.9" "" "" "" "" "" "" "" "" "" "" "296.6" "286.7" "307.7" "306.7" "313.6" "308.9" "278.1" "285.0" "277.3" "101.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6062365738304165802" "False" "High" "IsMasterProtein" "Q9BXY0" "Protein MAK16 homolog OS=Homo sapiens OX=9606 GN=MAK16 PE=1 SV=2" "0.000" "False" "20.947" "24" "5" "5" "5" "300" "35.3" "5.38" "21.65" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01778, Pf04874" "84549" "ENSG00000198042" "MAK16" "B2RB44; hsa:84549; Q5U5T1; Q86UC4; Q96SY6; Q9BXY0" "" "" "0" "0" "0.889" "0.972" "0.803" "0.915" "1.005" "0.964" "0.801" "0.966" "0.645" "201.5" "179.1" "195.9" "161.8" "184.3" "202.5" "194.2" "161.4" "194.6" "129.9" "" "" "" "" "" "" "" "" "" "" "181.1" "144.9" "177.2" "158.0" "152.1" "202.5" "145.4" "142.6" "174.1" "46.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6036892115816411697" "False" "High" "IsMasterProtein" "Q9H9G7" "Protein argonaute-3 OS=Homo sapiens OX=9606 GN=AGO3 PE=1 SV=2" "0.000" "False" "20.940" "9" "7" "7" "2" "860" "97.3" "9.11" "22.10" "7" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02170, Pf02171, Pf08699, Pf16486, Pf16487, Pf16488" "192669" "ENSG00000126070" "AGO3" "B1ALI0; hsa:192669; Q5TA55; Q9H1U6; Q9H9G7" "" "Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling; Regulation of MECP2 expression and activity; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; TP53 Regulates Metabolic Genes; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Small interfering RNA (siRNA) biogenesis; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Post-transcriptional silencing by small RNAs; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "21" "0" "1.193" "1.192" "1.032" "1.173" "1.104" "1.218" "1.171" "1.116" "1.050" "124.1" "148.0" "147.9" "128.0" "145.5" "137.0" "151.2" "145.3" "138.5" "130.3" "" "" "" "" "" "" "" "" "" "" "111.6" "119.8" "133.7" "125.0" "120.1" "137.0" "113.2" "128.3" "123.9" "46.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6722726084616143117" "False" "High" "IsMasterProtein" "Q9Y2U5" "Mitogen-activated protein kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP3K2 PE=1 SV=2" "0.000" "False" "20.930" "11" "7" "7" "7" "619" "69.7" "8.00" "23.75" "7" "other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00564" "10746" "ENSG00000169967" "MAP3K2" "B9EG87; hsa:10746; Q53QL9; Q53S75; Q59GZ6; Q8NC32; Q9NYK3; Q9Y2U5" "IL-1 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; EGF/EGFR signaling pathway; Insulin signaling; Pleural mesothelioma" "" "8" "0" "1.019" "0.989" "0.978" "1.062" "0.976" "1.028" "0.997" "1.037" "0.949" "426.2" "434.3" "421.6" "416.8" "452.5" "416.1" "438.2" "424.8" "441.8" "404.3" "" "" "" "" "" "" "" "" "" "" "383.2" "351.4" "381.3" "406.8" "373.4" "416.1" "328.1" "375.2" "395.3" "144.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889177674351520658" "False" "High" "IsMasterProtein" "Q8ND24" "RING finger protein 214 OS=Homo sapiens OX=9606 GN=RNF214 PE=1 SV=2" "0.000" "False" "20.890" "11" "7" "8" "7" "703" "77.6" "6.95" "24.65" "7" "" "" "other molecular function" "" "257160" "ENSG00000167257" "RNF214" "B2RUW0; B4DTD1; hsa:257160; Q8ND24" "" "" "0" "0" "1.037" "1.057" "1.012" "1.147" "1.078" "1.060" "1.113" "1.058" "1.552" "349.0" "361.9" "368.9" "353.1" "400.4" "376.1" "369.9" "388.5" "369.1" "541.7" "" "" "" "" "" "" "" "" "" "" "313.8" "292.8" "333.7" "344.7" "330.4" "376.1" "277.0" "343.1" "330.3" "193.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6090154179084716209" "False" "High" "IsMasterProtein" "P36551" "Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3" "0.000" "False" "20.883" "16" "6" "8" "6" "454" "50.1" "8.25" "23.23" "6" "other metabolic processes" "other membranes;cytosol;mitochondrion;other cell component" "other molecular function" "Pf01218" "1371" "ENSG00000080819" "CPOX" "A8K275; B4DSD5; hsa:1371; P36551; Q14060; Q53F08; Q8IZ45; Q96AF3" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "1.050" "0.987" "0.996" "1.048" "0.994" "1.040" "1.004" "1.042" "0.902" "516.1" "541.9" "509.3" "514.0" "540.9" "513.0" "536.8" "518.3" "537.9" "465.4" "" "" "" "" "" "" "" "" "" "" "464.0" "438.5" "460.7" "501.8" "446.3" "513.0" "401.9" "457.8" "481.3" "166.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3980746601808787358" "False" "High" "IsMasterProtein" "Q9P1U1" "Actin-related protein 3B OS=Homo sapiens OX=9606 GN=ACTR3B PE=1 SV=1" "0.000" "False" "20.862" "14" "5" "20" "1" "418" "47.6" "5.88" "61.98" "5" "" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00022" "57180" "ENSG00000133627" "ACTR3B" "A8MTG1; B4DFW4; hsa:57180; Q7Z526; Q96BT2; Q9P1U1" "" "" "0" "0" "0.880" "0.919" "1.004" "0.955" "1.139" "1.011" "1.045" "0.825" "0.854" "40.9" "36.0" "37.6" "41.1" "39.0" "46.6" "41.4" "42.7" "33.7" "34.9" "" "" "" "" "" "" "" "" "" "" "36.8" "29.1" "34.0" "40.1" "32.2" "46.6" "31.0" "37.7" "30.2" "12.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4003826422992493976" "False" "High" "IsMasterProtein" "Q9Y3D0" "Cytosolic iron-sulfur assembly component 2B OS=Homo sapiens OX=9606 GN=CIAO2B PE=1 SV=1" "0.000" "False" "20.855" "44" "4" "5" "4" "163" "17.7" "5.19" "26.08" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf01883" "51647" "ENSG00000166595" "CIAO2B" "hsa:51647; Q9Y3D0" "Iron-sulfur cluster biogenesis; 2q11.2 copy number variation syndrome" "Cytosolic iron-sulfur cluster assembly" "3" "0" "0.915" "0.922" "0.939" "1.018" "1.034" "0.937" "0.979" "1.059" "1.331" "444.0" "406.5" "409.3" "417.0" "451.9" "459.0" "415.8" "434.7" "470.1" "590.9" "" "" "" "" "" "" "" "" "" "" "399.2" "328.9" "370.2" "407.0" "372.9" "459.0" "311.4" "383.9" "420.7" "210.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773607396615155691" "False" "High" "IsMasterProtein" "Q16774" "Guanylate kinase OS=Homo sapiens OX=9606 GN=GUK1 PE=1 SV=2" "0.000" "False" "20.831" "36" "6" "7" "6" "197" "21.7" "6.55" "29.05" "6" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00625" "2987" "ENSG00000143774" "GUK1" "B1ANH1; hsa:2987; Q16774" "" "Interconversion of nucleotide di- and triphosphates; Azathioprine ADME" "2" "0" "0.972" "0.901" "0.932" "0.994" "0.881" "1.019" "0.962" "0.885" "0.971" "934.2" "908.3" "841.8" "870.7" "928.4" "822.9" "951.7" "898.8" "826.6" "906.9" "" "" "" "" "" "" "" "" "" "" "839.9" "735.0" "761.5" "849.9" "766.1" "822.9" "712.6" "793.9" "739.6" "323.7" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4875234499947995187" "False" "High" "IsMasterProtein" "Q93100" "Phosphorylase b kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PHKB PE=1 SV=3" "0.000" "False" "20.816" "6" "7" "7" "7" "1093" "124.8" "6.95" "24.98" "7" "other metabolic processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00723, Pf19292" "5257" "ENSG00000102893" "PHKB" "hsa:5257; Q8N4T5; Q93100" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.977" "0.961" "0.945" "1.024" "0.918" "1.004" "0.926" "1.018" "1.101" "533.6" "521.3" "513.1" "504.5" "546.6" "489.6" "535.8" "493.9" "543.0" "587.8" "" "" "" "" "" "" "" "" "" "" "479.8" "421.9" "464.1" "492.4" "451.1" "489.6" "401.2" "436.2" "485.8" "209.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "860011175530275491" "False" "High" "IsMasterProtein" "Q9H0Q0" "CYFIP-related Rac1 interactor A OS=Homo sapiens OX=9606 GN=CYRIA PE=1 SV=1" "0.000" "False" "20.815" "14" "3" "9" "1" "323" "37.3" "6.01" "32.45" "3" "cell organization and biogenesis" "other membranes" "other molecular function" "Pf07159" "81553" "ENSG00000197872" "CYRIA" "B3KNZ1; hsa:81553; Q53QW2; Q9H0Q0" "" "" "0" "0" "0.883" "0.911" "0.681" "0.884" "0.786" "0.636" "0.713" "0.744" "3.950" "25.6" "22.6" "23.3" "17.4" "22.6" "20.1" "16.3" "18.2" "19.0" "101.0" "" "" "" "" "" "" "" "" "" "" "23.0" "18.3" "21.1" "17.0" "18.6" "20.1" "12.2" "16.1" "17.0" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6660438545085976361" "False" "High" "IsMasterProtein" "Q9BUL5" "PHD finger protein 23 OS=Homo sapiens OX=9606 GN=PHF23 PE=1 SV=1" "0.000" "False" "20.803" "24" "8" "9" "8" "403" "43.8" "5.78" "34.54" "8" "other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13831" "79142" "ENSG00000040633" "PHF23" "A1DZ74; B3KVH8; B4DLK6; D3DTN4; hsa:79142; Q8IZK0; Q96HG7; Q9BUL5; Q9H5X0" "" "" "0" "0" "0.841" "1.055" "0.961" "1.048" "1.021" "0.925" "1.051" "1.125" "1.253" "373.4" "314.0" "394.0" "358.9" "391.5" "381.1" "345.3" "392.6" "420.2" "468.0" "" "" "" "" "" "" "" "" "" "" "335.7" "254.1" "356.4" "350.3" "323.0" "381.1" "258.6" "346.7" "376.0" "167.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1035023352736906795" "False" "High" "IsMasterProtein" "O00399" "Dynactin subunit 6 OS=Homo sapiens OX=9606 GN=DCTN6 PE=1 SV=1" "0.000" "False" "20.801" "31" "5" "9" "5" "190" "20.7" "6.32" "33.74" "5" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "10671" "ENSG00000104671" "DCTN6" "B2RAC1; hsa:10671; O00399" "Vasopressin-regulated water reabsorption" "MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-mediated anterograde transport; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.063" "1.123" "1.041" "1.087" "1.119" "1.044" "1.092" "1.175" "0.890" "1024.5" "1089.1" "1150.3" "1066.0" "1114.0" "1146.7" "1069.5" "1118.6" "1203.4" "912.2" "" "" "" "" "" "" "" "" "" "" "921.1" "881.3" "1040.5" "1040.6" "919.3" "1146.7" "800.8" "988.0" "1076.8" "325.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7107318601171383488" "False" "High" "IsMasterProtein" "Q9Y3C8" "Ubiquitin-fold modifier-conjugating enzyme 1 OS=Homo sapiens OX=9606 GN=UFC1 PE=1 SV=3" "0.000" "False" "20.795" "27" "6" "10" "6" "167" "19.4" "7.40" "31.56" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "" "other molecular function" "Pf08694" "51506" "ENSG00000143222" "UFC1" "A8K9R1; D3DVF9; hsa:51506; Q549X0; Q5VTX1; Q9BS96; Q9P009; Q9Y3C8" "" "" "0" "0" "1.066" "0.997" "1.094" "0.996" "1.291" "1.044" "1.107" "1.032" "0.853" "912.3" "972.3" "909.6" "998.2" "908.5" "1178.0" "952.4" "1009.8" "941.5" "778.1" "" "" "" "" "" "" "" "" "" "" "820.3" "786.7" "822.8" "974.4" "749.7" "1178.0" "713.1" "892.0" "842.4" "277.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1378614036355870767" "False" "High" "IsMasterProtein" "Q9UIV1" "CCR4-NOT transcription complex subunit 7 OS=Homo sapiens OX=9606 GN=CNOT7 PE=1 SV=3" "0.000" "False" "20.781" "16" "4" "6" "4" "285" "32.7" "4.84" "22.60" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04857" "29883" "ENSG00000198791" "CNOT7" "A8MZM5; B3KMP1; B3KN35; D3DSP6; G3V108; hsa:29883; Q7Z530; Q9UIV1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "0.954" "1.008" "0.964" "1.010" "1.017" "1.078" "1.095" "0.975" "1.426" "217.2" "207.2" "219.0" "209.4" "219.5" "220.9" "234.1" "237.8" "211.8" "309.8" "" "" "" "" "" "" "" "" "" "" "195.3" "167.7" "198.1" "204.4" "181.1" "220.9" "175.3" "210.0" "189.5" "110.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7247108035044904633" "False" "High" "IsMasterProtein" "P62244" "Small ribosomal subunit protein uS8 OS=Homo sapiens OX=9606 GN=RPS15A PE=1 SV=2" "0.000" "False" "20.779" "42" "5" "7" "5" "130" "14.8" "10.13" "23.29" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00410" "6210" "ENSG00000134419" "RPS15A" "hsa:6210; P39027; P39031; P62244; Q3MHD9; Q8C023; Q9BV24" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.874" "0.998" "0.873" "0.893" "0.983" "0.873" "0.926" "0.979" "1.484" "406.3" "355.2" "405.6" "354.7" "362.9" "399.3" "354.7" "376.4" "397.9" "603.0" "" "" "" "" "" "" "" "" "" "" "365.3" "287.4" "366.9" "346.2" "299.5" "399.3" "265.6" "332.5" "356.1" "215.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "208143562843118343" "False" "High" "IsMasterProtein" "Q8NFH5" "Nucleoporin NUP35 OS=Homo sapiens OX=9606 GN=NUP35 PE=1 SV=1" "0.000" "False" "20.757" "23" "5" "6" "5" "326" "34.8" "9.09" "26.90" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05172" "129401" "ENSG00000163002" "NUP35" "B4DP57; B4DYB4; hsa:129401; Q4ZFZ9; Q53S95; Q8NFH5; Q8TDJ1" "" "HCMV Late Events; Transport of Mature mRNA derived from an Intron-Containing Transcript; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Postmitotic nuclear pore complex (NPC) reformation" "29" "0" "0.963" "0.945" "0.973" "1.003" "0.964" "1.040" "1.002" "0.906" "0.901" "676.3" "651.1" "638.8" "658.1" "678.4" "651.6" "703.3" "677.9" "612.6" "609.2" "" "" "" "" "" "" "" "" "" "" "608.0" "526.8" "577.8" "642.4" "559.8" "651.6" "526.6" "598.8" "548.2" "217.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475093268658479309" "False" "High" "IsMasterProtein" "P61599" "N-alpha-acetyltransferase 20 OS=Homo sapiens OX=9606 GN=NAA20 PE=1 SV=1" "0.000" "False" "20.751" "47" "6" "7" "6" "178" "20.4" "5.03" "24.10" "6" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "51126" "ENSG00000173418" "NAA20" "A6NHA3; B2R4G4; hsa:51126; P61599; Q5TFT7; Q9D7H8; Q9H0Y4; Q9NQH6; Q9Y6D2" "Metapathway biotransformation Phase I and II" "" "1" "0" "0.988" "0.950" "0.921" "1.023" "0.996" "1.024" "1.017" "0.985" "0.867" "443.0" "437.5" "420.8" "408.1" "453.0" "441.0" "453.5" "450.5" "436.4" "383.9" "" "" "" "" "" "" "" "" "" "" "398.3" "354.0" "380.6" "398.3" "373.8" "441.0" "339.6" "397.9" "390.5" "137.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1884707447535219714" "False" "High" "IsMasterProtein" "Q9BYM8" "RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Homo sapiens OX=9606 GN=RBCK1 PE=1 SV=2" "0.000" "False" "20.742" "15" "6" "6" "6" "510" "57.5" "5.67" "20.28" "6" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf13445" "10616" "ENSG00000125826" "RBCK1" "O95623; Q86SL2; Q96BS3; Q9BYM8; Q9BYM9" "TAR syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "5" "0" "1.017" "1.059" "1.000" "1.200" "1.081" "1.073" "1.077" "1.224" "1.068" "140.8" "143.1" "149.1" "140.8" "169.0" "152.1" "151.1" "151.6" "172.3" "150.4" "" "" "" "" "" "" "" "" "" "" "126.6" "115.8" "134.9" "137.5" "139.4" "152.1" "113.1" "133.9" "154.2" "53.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8613494787005004283" "False" "High" "IsMasterProtein" "Q9BWJ5" "Splicing factor 3B subunit 5 OS=Homo sapiens OX=9606 GN=SF3B5 PE=1 SV=1" "0.000" "False" "20.715" "56" "4" "10" "4" "86" "10.1" "6.35" "34.55" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07189" "83443" "ENSG00000169976" "SF3B5" "B2R568; hsa:83443; Q7RTV1; Q9BWJ5" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "3" "0" "1.089" "1.032" "0.947" "1.106" "1.110" "1.142" "1.138" "1.114" "0.873" "756.8" "823.8" "780.7" "716.3" "837.2" "840.1" "864.4" "860.8" "843.3" "660.5" "" "" "" "" "" "" "" "" "" "" "680.4" "666.6" "706.2" "699.2" "690.9" "840.1" "647.3" "760.4" "754.6" "235.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5083710564544014092" "False" "High" "IsMasterProtein" "P84103" "Serine/arginine-rich splicing factor 3 OS=Homo sapiens OX=9606 GN=SRSF3 PE=1 SV=1" "0.000" "False" "20.674" "23" "4" "11" "3" "164" "19.3" "11.65" "37.53" "4" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6428" "ENSG00000112081" "SRSF3" "B4E241; hsa:6428; O08831; P23152; P84103; Q5R3K0" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "6" "0" "0.915" "0.779" "1.083" "0.772" "0.981" "0.971" "0.919" "0.769" "0.672" "353.4" "323.2" "275.3" "382.8" "272.7" "346.8" "343.1" "324.6" "271.8" "237.4" "" "" "" "" "" "" "" "" "" "" "317.7" "261.5" "249.1" "373.6" "225.0" "346.8" "256.9" "286.7" "243.2" "84.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4850217669682801799" "False" "High" "IsMasterProtein" "Q9NZD8" "Maspardin OS=Homo sapiens OX=9606 GN=SPG21 PE=1 SV=1" "0.000" "False" "20.669" "23" "6" "7" "6" "308" "34.9" "6.28" "23.27" "6" "signal transduction" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding" "Pf00561" "51324" "ENSG00000090487" "SPG21" "B4DW44; Q6ZMB6; Q9NZD8" "" "" "0" "0" "1.053" "1.103" "0.950" "1.071" "0.918" "1.018" "0.982" "1.045" "1.323" "347.4" "365.8" "383.3" "329.9" "372.2" "318.8" "353.5" "341.2" "363.1" "459.6" "" "" "" "" "" "" "" "" "" "" "312.3" "296.0" "346.7" "322.1" "307.1" "318.8" "264.7" "301.4" "324.9" "164.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4549685978582378632" "False" "High" "IsMasterProtein" "Q9Y399" "Small ribosomal subunit protein uS2m OS=Homo sapiens OX=9606 GN=MRPS2 PE=1 SV=1" "0.000" "False" "20.668" "21" "6" "9" "6" "296" "33.2" "9.26" "27.30" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00318" "51116" "ENSG00000122140" "MRPS2" "hsa:51116; Q5T899; Q9BSQ4; Q9Y399" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.975" "0.905" "0.899" "0.917" "0.903" "0.940" "0.846" "0.887" "1.289" "645.1" "629.0" "584.0" "580.2" "591.7" "582.3" "606.7" "546.0" "571.9" "831.8" "" "" "" "" "" "" "" "" "" "" "580.0" "508.9" "528.2" "566.4" "488.2" "582.3" "454.3" "482.3" "511.8" "296.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530850700352278513" "False" "High" "IsMasterProtein" "Q15700" "Disks large homolog 2 OS=Homo sapiens OX=9606 GN=DLG2 PE=1 SV=3" "0.000" "False" "20.650" "9" "7" "8" "5" "870" "97.5" "6.47" "27.18" "7" "cell adhesion;cell-cell signaling;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600, Pf10608" "1740" "ENSG00000150672" "DLG2" "B7WNY8; F8W9V6; hsa:1740; Q15700; Q59G57; Q5H9Q4; Q68CQ8; Q6ZTA8" "Disruption of postsynaptic signaling by CNV; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "Assembly and cell surface presentation of NMDA receptors; RAF/MAP kinase cascade; Neurexins and neuroligins; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation" "10" "0" "1.016" "0.994" "1.009" "0.869" "0.898" "0.869" "0.971" "0.905" "0.927" "49.8" "50.6" "49.5" "50.3" "43.3" "44.8" "43.3" "48.4" "45.1" "46.2" "" "" "" "" "" "" "" "" "" "" "44.8" "41.0" "44.8" "49.1" "35.7" "44.8" "32.4" "42.7" "40.3" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6953685933096655099" "False" "High" "IsMasterProtein" "Q8N465" "D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=D2HGDH PE=1 SV=3" "0.000" "False" "20.648" "14" "7" "7" "7" "521" "56.4" "7.99" "24.97" "7" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01565, Pf02913" "728294" "ENSG00000180902" "D2HGDH" "B4E3L6; E7ENP2; hsa:728294; Q6IQ24; Q8N465; Q8N5Q8" "2q37 copy number variation syndrome" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "1.047" "1.035" "0.974" "1.084" "0.995" "1.020" "0.935" "0.928" "0.821" "339.1" "355.0" "350.9" "330.3" "367.6" "337.6" "346.0" "317.0" "314.7" "278.2" "" "" "" "" "" "" "" "" "" "" "304.9" "287.3" "317.4" "322.4" "303.3" "337.6" "259.1" "280.0" "281.6" "99.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8334369527451810461" "False" "High" "IsMasterProtein" "Q8NF64" "Zinc finger MIZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZMIZ2 PE=1 SV=2" "0.000" "False" "20.640" "8" "6" "7" "2" "920" "96.5" "7.12" "25.05" "6" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf02891" "83637" "ENSG00000122515" "ZMIZ2" "A4D2K7; D3DVL1; hsa:83637; O94790; Q0VGB4; Q659A8; Q6JKL5; Q8NF64; Q8WTX8; Q96Q01; Q9BQH7" "" "" "0" "0" "0.918" "0.921" "0.891" "0.905" "0.945" "0.946" "0.983" "0.920" "0.929" "206.2" "189.2" "189.9" "183.6" "186.5" "194.9" "195.0" "202.7" "189.7" "191.7" "" "" "" "" "" "" "" "" "" "" "185.4" "153.1" "171.7" "179.2" "153.9" "194.9" "146.0" "179.0" "169.7" "68.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5267554590826270529" "False" "High" "IsMasterProtein" "P62380" "TATA box-binding protein-like 1 OS=Homo sapiens OX=9606 GN=TBPL1 PE=1 SV=1" "0.000" "False" "20.626" "18" "3" "6" "3" "186" "20.9" "9.54" "27.20" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "9519" "ENSG00000028839" "TBPL1" "A8K8F5; hsa:9519; O95753; P62380; Q9BWD5; Q9Z2Z0" "" "" "0" "0" "1.002" "1.009" "0.922" "0.986" "0.839" "0.985" "0.926" "0.974" "0.942" "454.2" "455.3" "458.4" "418.6" "447.7" "381.1" "447.4" "420.4" "442.5" "427.8" "" "" "" "" "" "" "" "" "" "" "408.4" "368.4" "414.6" "408.6" "369.4" "381.1" "335.0" "371.4" "395.9" "152.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6836769617334137947" "False" "High" "IsMasterProtein" "Q96LA8" "Protein arginine N-methyltransferase 6 OS=Homo sapiens OX=9606 GN=PRMT6 PE=1 SV=1" "0.000" "False" "20.583" "18" "6" "7" "6" "375" "41.9" "5.44" "24.49" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf13649" "55170" "ENSG00000198890" "PRMT6" "A3KME1; B4DID8; hsa:55170; Q5T5Y5; Q6DKI4; Q96LA8; Q9NVR8" "Male infertility; Nitric oxide metabolism in cystic fibrosis" "RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RMTs methylate histone arginines" "4" "0" "1.139" "0.956" "0.955" "1.059" "0.972" "1.031" "1.092" "1.029" "0.833" "514.1" "585.4" "491.5" "491.1" "544.5" "499.8" "530.1" "561.4" "529.1" "428.3" "" "" "" "" "" "" "" "" "" "" "462.3" "473.6" "444.6" "479.4" "449.3" "499.8" "397.0" "495.9" "473.5" "152.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4765552648658305889" "False" "High" "IsMasterProtein" "Q96JH7" "Deubiquitinating protein VCPIP1 OS=Homo sapiens OX=9606 GN=VCPIP1 PE=1 SV=2" "0.000" "False" "20.561" "5" "6" "8" "6" "1222" "134.2" "7.20" "28.04" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02338, Pf19437, Pf21403" "80124" "ENSG00000175073" "VCPIP1" "hsa:80124; Q504T4; Q86T93; Q86W01; Q8N3A9; Q96JH7; Q9H5R8" "Alstrom syndrome" "Ovarian tumor domain proteases" "2" "0" "1.025" "0.946" "1.016" "1.077" "1.006" "1.180" "1.038" "1.009" "6.379" "91.7" "94.0" "86.7" "93.1" "98.7" "92.2" "108.2" "95.2" "92.5" "584.6" "" "" "" "" "" "" "" "" "" "" "82.4" "76.0" "78.4" "90.9" "81.5" "92.2" "81.0" "84.1" "82.8" "208.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2487485535113900715" "False" "High" "IsMasterProtein" "Q9UGK8" "Secretion-regulating guanine nucleotide exchange factor OS=Homo sapiens OX=9606 GN=SERGEF PE=1 SV=2" "0.000" "False" "20.561" "14" "5" "6" "5" "458" "49.0" "6.46" "20.21" "5" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf00415, Pf13540" "26297" "ENSG00000129158" "SERGEF" "hsa:26297; Q9UGK8; Q9UGK9" "" "" "0" "0" "1.066" "1.032" "1.001" "1.108" "1.038" "1.113" "0.998" "1.043" "1.072" "342.1" "364.7" "353.2" "342.4" "378.9" "355.1" "380.9" "341.4" "356.6" "366.6" "" "" "" "" "" "" "" "" "" "" "307.6" "295.1" "319.4" "334.3" "312.7" "355.1" "285.2" "301.6" "319.1" "130.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7864399280568064191" "False" "High" "IsMasterProtein" "Q9BT23" "LIM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LIMD2 PE=1 SV=1" "0.000" "False" "20.549" "39" "7" "14" "6" "127" "14.1" "9.03" "41.74" "7" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00412" "80774" "ENSG00000136490" "LIMD2" "D3DU16; hsa:80774; Q96S91; Q9BT23" "" "" "0" "0" "1.077" "1.012" "1.062" "1.045" "1.107" "1.050" "1.129" "1.163" "0.819" "1368.1" "1473.6" "1384.9" "1453.4" "1429.3" "1514.1" "1436.4" "1544.5" "1591.4" "1119.9" "" "" "" "" "" "" "" "" "" "" "1230.1" "1192.4" "1252.7" "1418.8" "1179.4" "1514.1" "1075.5" "1364.2" "1424.0" "399.8" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2746041825889845794" "False" "High" "IsMasterProtein" "Q15059" "Bromodomain-containing protein 3 OS=Homo sapiens OX=9606 GN=BRD3 PE=1 SV=1" "0.000" "False" "20.527" "10" "7" "7" "3" "726" "79.5" "9.36" "23.40" "7" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00439, Pf17035" "8019" "ENSG00000169925" "BRD3" "B1APD9; hsa:8019; Q15059; Q4G5Y3; Q5T1R7; Q8N5M3; Q92645" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7340038753290804182" "False" "High" "IsMasterProtein" "Q9Y5B9" "FACT complex subunit SPT16 OS=Homo sapiens OX=9606 GN=SUPT16H PE=1 SV=1" "0.000" "False" "20.524" "6" "7" "8" "7" "1047" "119.8" "5.66" "23.20" "7" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf00557, Pf08512, Pf08644, Pf14826, Pf21091" "11198" "ENSG00000092201" "SUPT16H" "hsa:11198; Q6GMT8; Q6P2F1; Q6PJM1; Q9NRX0; Q9Y5B9" "" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation" "12" "0" "0.996" "0.864" "0.905" "0.999" "1.001" "0.920" "0.901" "1.067" "0.721" "366.9" "365.6" "317.0" "332.0" "366.6" "367.1" "337.7" "330.7" "391.5" "264.4" "" "" "" "" "" "" "" "" "" "" "329.8" "295.8" "286.7" "324.1" "302.5" "367.1" "252.9" "292.1" "350.3" "94.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5057410005729893010" "False" "High" "IsMasterProtein" "Q7Z4Q2" "HEAT repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=HEATR3 PE=1 SV=2" "0.000" "False" "20.519" "8" "5" "9" "5" "680" "74.5" "5.11" "27.12" "5" "transport;other biological processes" "" "other molecular function" "Pf13513" "55027" "ENSG00000155393" "HEATR3" "A8K1N4; hsa:55027; Q7Z4Q2; Q8N525; Q8WV56; Q96CC9; Q9NWN7" "" "" "0" "0" "1.054" "0.921" "0.967" "0.956" "0.970" "1.086" "1.098" "0.985" "1.486" "275.8" "290.6" "254.1" "266.7" "263.6" "267.6" "299.4" "302.8" "271.7" "409.8" "" "" "" "" "" "" "" "" "" "" "247.9" "235.2" "229.8" "260.4" "217.5" "267.6" "224.2" "267.4" "243.1" "146.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3875322263221301035" "False" "High" "IsMasterProtein" "P51553" "Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial OS=Homo sapiens OX=9606 GN=IDH3G PE=1 SV=1" "0.000" "False" "20.498" "20" "6" "7" "6" "393" "42.8" "8.50" "28.29" "6" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf00180" "3421" "ENSG00000067829" "IDH3G" "E9PDD5; hsa:3421; P51553; Q9BUU5" "TCA cycle (aka Krebs or citric acid cycle)" "Citric acid cycle (TCA cycle); Mitochondrial protein import" "3" "0" "1.044" "1.051" "1.080" "0.904" "1.112" "1.070" "1.061" "1.017" "0.838" "196.2" "204.9" "206.2" "211.8" "177.4" "218.2" "209.9" "208.2" "199.5" "164.5" "" "" "" "" "" "" "" "" "" "" "176.4" "165.8" "186.5" "206.8" "146.4" "218.2" "157.2" "183.9" "178.5" "58.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "884505446193914017" "False" "High" "IsMasterProtein" "O43752" "Syntaxin-6 OS=Homo sapiens OX=9606 GN=STX6 PE=1 SV=1" "0.000" "False" "20.477" "19" "4" "8" "3" "255" "29.2" "4.93" "28.09" "4" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739, Pf09177" "10228" "ENSG00000135823" "STX6" "B2R652; B4DR17; hsa:10228; O43752; Q5VY08; Q6FH83" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "1" "1.161" "0.947" "1.119" "1.309" "1.318" "1.272" "1.061" "1.290" "0.976" "448.6" "520.6" "424.9" "501.9" "587.0" "591.2" "570.8" "475.8" "578.6" "437.9" "" "" "" "" "" "" "" "" "" "" "403.3" "421.3" "384.3" "490.0" "484.4" "591.2" "427.4" "420.2" "517.8" "156.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6165163621982420395" "False" "High" "IsMasterProtein" "P42694" "Probable helicase with zinc finger domain OS=Homo sapiens OX=9606 GN=HELZ PE=1 SV=2" "0.000" "False" "20.475" "3" "7" "8" "7" "1942" "218.8" "7.42" "24.27" "7" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00642, Pf13086, Pf13087" "9931" "ENSG00000198265" "HELZ" "hsa:9931; I6L9H4; P42694" "" "" "0" "0" "1.073" "0.924" "0.985" "1.090" "1.049" "1.207" "1.061" "0.914" "1.330" "156.7" "168.1" "144.8" "154.3" "170.9" "164.4" "189.1" "166.3" "143.3" "208.4" "" "" "" "" "" "" "" "" "" "" "140.9" "136.0" "131.0" "150.6" "141.0" "164.4" "141.6" "146.9" "128.2" "74.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3970061411929191167" "False" "High" "IsMasterProtein" "Q96G61" "Diphosphoinositol polyphosphate phosphohydrolase 3-beta OS=Homo sapiens OX=9606 GN=NUDT11 PE=1 SV=1" "0.000" "False" "20.474" "35" "5" "7" "3" "164" "18.5" "5.99" "22.29" "5" "other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00293" "55190" "ENSG00000196368" "NUDT11" "hsa:55190; Q96G61; Q9NVN0" "" "Synthesis of pyrophosphates in the cytosol" "1" "0" "1.073" "1.117" "1.023" "1.077" "1.022" "1.066" "1.035" "0.981" "1.803" "367.6" "394.4" "410.4" "376.2" "395.7" "375.8" "391.8" "380.6" "360.6" "662.7" "" "" "" "" "" "" "" "" "" "" "330.5" "319.1" "371.3" "367.2" "326.6" "375.8" "293.4" "336.1" "322.7" "236.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1487358643357756863" "False" "High" "IsMasterProtein" "P41214" "Eukaryotic translation initiation factor 2D OS=Homo sapiens OX=9606 GN=EIF2D PE=1 SV=3" "0.000" "False" "20.464" "13" "6" "8" "6" "584" "64.7" "7.65" "20.26" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01253, Pf17832" "1939" "ENSG00000143486" "EIF2D" "hsa:1939; P41214; Q5SY40; Q8IXV3; Q96DG3; Q96TG7; Q9NR27; Q9NSN0; Q9NV18; Q9NZ21" "" "" "0" "0" "1.018" "1.068" "1.008" "1.083" "1.015" "1.154" "0.994" "1.077" "2.144" "326.7" "332.6" "348.8" "329.4" "353.8" "331.6" "377.1" "324.7" "351.9" "700.4" "" "" "" "" "" "" "" "" "" "" "293.7" "269.2" "315.5" "321.5" "291.9" "331.6" "282.3" "286.8" "314.9" "250.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4923515790283792107" "False" "High" "IsMasterProtein" "Q7Z309" "PABIR family member 2 OS=Homo sapiens OX=9606 GN=PABIR2 PE=1 SV=2" "0.000" "False" "20.460" "22" "5" "9" "5" "247" "26.9" "6.37" "18.77" "5" "" "" "enzyme regulator activity" "" "159090" "ENSG00000156504" "PABIR2" "A8K902; hsa:159090; Q6PIM2; Q6ZU47; Q6ZV64; Q6ZVE4; Q7Z309; Q8TB75" "" "" "0" "0" "1.017" "1.014" "0.945" "1.020" "1.028" "0.923" "1.045" "0.993" "0.921" "423.8" "430.8" "429.8" "400.6" "432.2" "435.7" "391.2" "442.8" "420.9" "390.4" "" "" "" "" "" "" "" "" "" "" "381.1" "348.6" "388.8" "391.1" "356.7" "435.7" "292.9" "391.1" "376.6" "139.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7220611050320335909" "False" "High" "IsMasterProtein" "Q8TDH9" "Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Homo sapiens OX=9606 GN=BLOC1S5 PE=1 SV=1" "0.000" "False" "20.458" "31" "6" "7" "6" "187" "21.6" "7.59" "20.68" "6" "cell organization and biogenesis;transport;developmental processes;other biological processes" "ER/Golgi;other cell component" "" "Pf14942" "63915" "ENSG00000188428" "BLOC1S5" "B4DVM2; hsa:63915; Q0VDJ6; Q0VDJ7; Q5THS1; Q68D56; Q8N5F9; Q8TDH9; Q9NU16" "" "" "0" "0" "1.057" "0.968" "0.994" "1.035" "1.065" "1.091" "1.125" "1.022" "0.960" "347.2" "366.9" "336.1" "345.1" "359.2" "369.9" "378.9" "390.6" "354.7" "333.5" "" "" "" "" "" "" "" "" "" "" "312.2" "296.9" "304.0" "336.9" "296.4" "369.9" "283.7" "345.0" "317.4" "119.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181742408378363027" "False" "High" "IsMasterProtein" "P62253" "Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens OX=9606 GN=UBE2G1 PE=1 SV=3" "0.000" "False" "20.448" "31" "5" "10" "5" "170" "19.5" "5.30" "30.84" "5" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00179" "7326" "ENSG00000132388" "UBE2G1" "B2R7P2; D3DTK0; hsa:7326; P62253; Q99462" "Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "4" "0" "1.009" "0.968" "0.939" "1.086" "1.118" "1.106" "1.165" "0.968" "0.840" "581.2" "586.2" "562.4" "546.0" "631.1" "649.8" "642.9" "676.9" "562.8" "488.2" "" "" "" "" "" "" "" "" "" "" "522.6" "474.3" "508.7" "533.0" "520.8" "649.8" "481.4" "597.9" "503.5" "174.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967906594537230573" "False" "High" "IsMasterProtein" "Q9NUG6" "p53 and DNA damage-regulated protein 1 OS=Homo sapiens OX=9606 GN=PDRG1 PE=1 SV=2" "0.000" "False" "20.448" "35" "5" "9" "5" "133" "15.5" "6.06" "26.20" "5" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf01920" "81572" "ENSG00000088356" "PDRG1" "B2R511; hsa:81572; Q96GP3; Q9BUW8; Q9NUG6" "" "" "0" "0" "0.975" "0.959" "0.985" "0.991" "1.037" "0.975" "1.071" "1.051" "1.071" "931.7" "908.9" "893.8" "917.8" "923.4" "966.3" "908.7" "998.1" "979.7" "997.8" "" "" "" "" "" "" "" "" "" "" "837.7" "735.4" "808.5" "895.9" "762.0" "966.3" "680.4" "881.6" "876.6" "356.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6562177240292846235" "False" "High" "IsMasterProtein" "Q99490" "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=AGAP2 PE=1 SV=2" "0.000" "False" "20.405" "6" "7" "8" "7" "1192" "124.6" "9.89" "24.97" "7" "cell organization and biogenesis;transport;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf00071, Pf01412" "116986" "ENSG00000135439" "AGAP2" "A8K9F7; hsa:116986; O00578; Q548E0; Q8IWU3; Q99490" "Prolactin signaling pathway; Fragile X syndrome; Netrin-UNC5B signaling pathway; 15q25 copy number variation" "Netrin-1 signaling" "5" "0" "1.057" "0.999" "1.055" "0.938" "1.023" "1.075" "1.006" "1.006" "1.493" "476.3" "503.5" "475.6" "502.3" "446.9" "487.1" "511.8" "479.1" "479.0" "711.3" "" "" "" "" "" "" "" "" "" "" "428.2" "407.4" "430.2" "490.3" "368.8" "487.1" "383.2" "423.2" "428.6" "253.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4381387929152042020" "False" "High" "IsMasterProtein" "Q9ULX3" "RNA-binding protein NOB1 OS=Homo sapiens OX=9606 GN=NOB1 PE=1 SV=1" "0.000" "False" "20.401" "17" "6" "6" "6" "412" "46.6" "7.18" "24.60" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08772, Pf15017, Pf17146" "28987" "ENSG00000141101" "NOB1" "hsa:28987; Q7L6B7; Q7M4M4; Q7Z4B5; Q9NWB0; Q9ULX3" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.941" "0.942" "1.009" "0.966" "0.947" "0.968" "0.897" "0.960" "1.365" "411.0" "386.9" "387.2" "414.5" "397.2" "389.1" "397.9" "368.8" "394.7" "561.1" "" "" "" "" "" "" "" "" "" "" "369.5" "313.1" "350.2" "404.6" "327.8" "389.1" "297.9" "325.8" "353.2" "200.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923018383904393967" "False" "High" "IsMasterProtein" "Q8TAP6" "Centrosomal protein of 76 kDa OS=Homo sapiens OX=9606 GN=CEP76 PE=1 SV=1" "0.000" "False" "20.390" "10" "7" "8" "7" "659" "74.4" "6.74" "19.87" "7" "other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf15627" "79959" "ENSG00000101624" "CEP76" "B0YJB2; B4DXG5; B4DZW1; hsa:79959; Q658N5; Q8TAP6; Q9H9U7" "Genes related to primary cilium development (based on CRISPR)" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "8" "0" "1.063" "1.062" "0.968" "0.940" "1.174" "1.135" "1.077" "1.060" "0.966" "200.4" "213.1" "213.0" "194.1" "188.4" "235.2" "227.5" "215.9" "212.5" "193.6" "" "" "" "" "" "" "" "" "" "" "180.2" "172.4" "192.6" "189.5" "155.5" "235.2" "170.4" "190.7" "190.2" "69.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7634397569492690707" "False" "High" "IsMasterProtein" "Q96HY7" "2-oxoadipate dehydrogenase complex component E1 OS=Homo sapiens OX=9606 GN=DHTKD1 PE=1 SV=2" "0.000" "False" "20.387" "9" "7" "9" "7" "919" "103.0" "6.93" "32.39" "7" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00676, Pf02779, Pf16870" "55526" "ENSG00000181192" "DHTKD1" "hsa:55526; Q68CU5; Q96HY7; Q9BUM8; Q9HCE2" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "0.910" "0.766" "0.948" "0.845" "0.703" "0.961" "0.832" "0.742" "1.000" "717.6" "653.2" "549.3" "680.1" "606.6" "504.7" "689.4" "597.2" "532.7" "717.4" "" "" "" "" "" "" "" "" "" "" "645.2" "528.5" "496.9" "663.9" "500.6" "504.7" "516.2" "527.5" "476.7" "256.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2936218477733222076" "False" "High" "IsMasterProtein" "Q8N6T7" "NAD-dependent protein deacylase sirtuin-6 OS=Homo sapiens OX=9606 GN=SIRT6 PE=1 SV=2" "0.000" "False" "20.383" "19" "6" "7" "6" "355" "39.1" "9.19" "22.41" "6" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "51548" "ENSG00000077463" "SIRT6" "B2RCD0; hsa:51548; O75291; Q6IAF5; Q6PK99; Q8N6T7; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1" "SREBF and miR33 in cholesterol and lipid homeostasis; NAD+ metabolism; NAD+ biosynthetic pathways; Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 10q11.21q11.23 copy number variation syndrome" "Pre-NOTCH Transcription and Translation; Processing of DNA double-strand break ends" "9" "0" "1.040" "1.023" "0.965" "1.103" "1.014" "1.045" "1.031" "1.185" "1.028" "271.6" "282.5" "277.9" "262.2" "299.7" "275.6" "283.8" "280.2" "321.8" "279.2" "" "" "" "" "" "" "" "" "" "" "244.2" "228.6" "251.4" "255.9" "247.3" "275.6" "212.5" "247.5" "287.9" "99.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5713044218766232811" "False" "High" "IsMasterProtein" "Q9NXR7" "BRISC and BRCA1-A complex member 2 OS=Homo sapiens OX=9606 GN=BABAM2 PE=1 SV=2" "0.000" "False" "20.369" "16" "6" "7" "6" "383" "43.5" "5.81" "22.61" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf06113" "9577" "ENSG00000158019" "BABAM2" "A8K4X1; D6W562; D6W563; hsa:9577; Q13880; Q4ZFX8; Q53SD0; Q969X9; Q96P06; Q9NXR7" "5q35 copy number variation" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.034" "0.935" "0.980" "1.088" "0.961" "0.889" "0.975" "1.019" "0.855" "292.6" "302.7" "273.7" "286.7" "318.5" "281.1" "260.1" "285.3" "298.1" "250.2" "" "" "" "" "" "" "" "" "" "" "263.1" "244.9" "247.6" "279.8" "262.8" "281.1" "194.7" "252.0" "266.7" "89.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002757993896463050" "False" "High" "IsMasterProtein" "Q9NQW6" "Anillin OS=Homo sapiens OX=9606 GN=ANLN PE=1 SV=2" "0.000" "False" "20.360" "6" "7" "7" "7" "1124" "124.1" "8.07" "22.31" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00169, Pf08174, Pf16018" "54443" "ENSG00000011426" "ANLN" "hsa:54443; Q5CZ78; Q6NSK5; Q9H8Y4; Q9NQW6; Q9NVN9; Q9NVP0" "Retinoblastoma gene in cancer; Nephrotic syndrome" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle" "5" "0" "1.203" "1.292" "0.999" "1.150" "1.417" "1.184" "1.028" "1.277" "2.809" "195.7" "235.5" "252.8" "195.5" "225.0" "277.2" "231.7" "201.1" "250.0" "549.7" "" "" "" "" "" "" "" "" "" "" "176.0" "190.6" "228.7" "190.8" "185.7" "277.2" "173.5" "177.7" "223.7" "196.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2096625671163089170" "False" "High" "IsMasterProtein" "O95999" "B-cell lymphoma/leukemia 10 OS=Homo sapiens OX=9606 GN=BCL10 PE=1 SV=1" "0.000" "False" "20.344" "24" "6" "7" "6" "233" "26.2" "5.74" "21.25" "6" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00619" "8915" "ENSG00000142867" "BCL10" "hsa:8915; O95999; Q5VUF1" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; E3 ubiquitin ligases ubiquitinate target proteins; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "9" "0" "0.953" "0.884" "0.907" "0.998" "0.930" "1.013" "0.977" "0.961" "1.050" "445.0" "423.8" "393.5" "403.5" "444.1" "414.0" "450.5" "434.6" "427.6" "467.2" "" "" "" "" "" "" "" "" "" "" "400.1" "343.0" "355.9" "393.9" "366.5" "414.0" "337.4" "383.8" "382.6" "166.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8979611846707191829" "False" "High" "IsMasterProtein" "O76080" "AN1-type zinc finger protein 5 OS=Homo sapiens OX=9606 GN=ZFAND5 PE=1 SV=1" "0.000" "False" "20.317" "29" "4" "5" "4" "213" "23.1" "8.51" "21.84" "4" "developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "7763" "ENSG00000107372" "ZFAND5" "A8K484; hsa:7763; O76080" "" "" "0" "0" "0.923" "0.987" "1.008" "0.974" "1.010" "0.952" "0.972" "1.016" "0.771" "526.5" "486.0" "519.5" "530.7" "512.9" "531.8" "501.1" "511.7" "535.0" "405.8" "" "" "" "" "" "" "" "" "" "" "473.4" "393.2" "469.9" "518.0" "423.2" "531.8" "375.2" "452.0" "478.7" "144.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1299453744240154091" "False" "High" "IsMasterProtein" "Q96EB1" "Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2" "0.000" "False" "20.315" "11" "5" "8" "5" "424" "46.6" "8.51" "26.10" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf05625" "26610" "ENSG00000109911" "ELP4" "B4E3W0; E7EPZ6; hsa:26610; Q96EB1; Q9H4E8; Q9NX11" "Mesodermal commitment pathway" "HATs acetylate histones" "2" "0" "1.008" "0.964" "0.984" "0.966" "0.974" "0.961" "0.952" "1.031" "0.810" "761.0" "767.0" "733.6" "749.0" "735.0" "740.9" "731.5" "724.2" "784.8" "616.4" "" "" "" "" "" "" "" "" "" "" "684.2" "620.6" "663.5" "731.1" "606.5" "740.9" "547.7" "639.6" "702.2" "220.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981502460717336485" "False" "High" "IsMasterProtein" "O60244" "Mediator of RNA polymerase II transcription subunit 14 OS=Homo sapiens OX=9606 GN=MED14 PE=1 SV=2" "0.000" "False" "20.315" "4" "5" "6" "5" "1454" "160.5" "8.73" "21.71" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08638" "9282" "ENSG00000180182" "MED14" "hsa:9282; O60244; Q4KMR7; Q9UNB3" "Vitamin D in inflammatory diseases" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "5" "0" "0.960" "0.998" "0.893" "0.944" "0.974" "0.894" "0.857" "0.984" "0.985" "425.2" "408.2" "424.1" "379.6" "401.2" "414.2" "380.0" "364.5" "418.4" "418.8" "" "" "" "" "" "" "" "" "" "" "382.3" "330.3" "383.6" "370.6" "331.1" "414.2" "284.5" "322.0" "374.4" "149.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3800161177308876944" "False" "High" "IsMasterProtein" "Q8NEM2" "SHC SH2 domain-binding protein 1 OS=Homo sapiens OX=9606 GN=SHCBP1 PE=1 SV=3" "0.000" "False" "20.312" "10" "5" "6" "5" "672" "75.6" "4.75" "24.26" "5" "signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf13229" "79801" "ENSG00000171241" "SHCBP1" "hsa:79801; Q8NEM2; Q96N60; Q9BVS0; Q9H6P6" "Genetic causes of porto-sinusoidal vascular disease" "" "1" "0" "1.081" "1.297" "0.886" "1.005" "1.249" "1.140" "0.985" "1.290" "3.411" "259.7" "280.6" "336.9" "230.0" "261.1" "324.4" "295.9" "255.7" "334.9" "885.8" "" "" "" "" "" "" "" "" "" "" "233.5" "227.1" "304.7" "224.5" "215.5" "324.4" "221.6" "225.9" "299.7" "316.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9085174644749999284" "False" "High" "IsMasterProtein" "Q4G0F5" "Vacuolar protein sorting-associated protein 26B OS=Homo sapiens OX=9606 GN=VPS26B PE=1 SV=2" "0.000" "False" "20.300" "21" "7" "9" "5" "336" "39.1" "7.36" "26.72" "7" "stress response;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "" "Pf03643" "112936" "ENSG00000151502" "VPS26B" "hsa:112936; Q4G0F5; Q96A55" "" "" "0" "0" "1.229" "1.099" "1.188" "0.966" "0.985" "1.084" "1.087" "1.053" "0.916" "67.1" "82.5" "73.7" "79.7" "64.8" "66.1" "72.7" "72.9" "70.6" "61.5" "" "" "" "" "" "" "" "" "" "" "60.3" "66.8" "66.7" "77.8" "53.5" "66.1" "54.5" "64.4" "63.2" "22.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-979600656900959777" "False" "High" "IsMasterProtein" "Q9HD40" "O-phosphoseryl-tRNA(Sec) selenium transferase OS=Homo sapiens OX=9606 GN=SEPSECS PE=1 SV=2" "0.000" "False" "20.277" "13" "6" "6" "6" "501" "55.7" "8.05" "16.20" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05889" "51091" "ENSG00000109618" "SEPSECS" "A8K8W1; hsa:51091; Q0D2P3; Q17RT1; Q9HD40; Q9NXZ5; Q9UGM9; Q9Y353" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "1.002" "0.920" "0.936" "1.027" "0.939" "1.019" "1.060" "0.939" "0.863" "358.4" "359.1" "329.8" "335.4" "368.1" "336.4" "365.4" "379.9" "336.5" "309.4" "" "" "" "" "" "" "" "" "" "" "322.3" "290.6" "298.4" "327.4" "303.8" "336.4" "273.6" "335.5" "301.1" "110.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2825155014730555615" "False" "High" "IsMasterProtein" "Q6GMV2" "Histone-lysine N-trimethyltransferase SMYD5 OS=Homo sapiens OX=9606 GN=SMYD5 PE=1 SV=2" "0.000" "False" "20.257" "12" "5" "7" "5" "418" "47.3" "5.05" "24.34" "5" "cell organization and biogenesis;other metabolic processes;other biological processes" "" "other molecular function" "Pf00856" "10322" "ENSG00000135632" "SMYD5" "D6W5H3; hsa:10322; Q13558; Q6GMV2" "Histone modifications" "" "1" "0" "1.002" "0.956" "0.997" "0.988" "0.922" "1.024" "0.977" "1.023" "0.781" "860.7" "862.8" "823.0" "858.3" "850.4" "793.4" "880.9" "840.8" "880.7" "672.1" "" "" "" "" "" "" "" "" "" "" "773.8" "698.1" "744.5" "837.8" "701.7" "793.4" "659.6" "742.6" "788.0" "239.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8485123881553311665" "False" "High" "IsMasterProtein" "Q8TEB1" "DDB1- and CUL4-associated factor 11 OS=Homo sapiens OX=9606 GN=DCAF11 PE=1 SV=1" "0.000" "False" "20.248" "9" "4" "6" "4" "546" "61.6" "6.40" "20.74" "4" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf00400" "80344" "ENSG00000100897; ENSG00000284796" "DCAF11" "B3KQ83; D3DS56; hsa:80344; Q5D039; Q86U00; Q86U39; Q8NDN2; Q8TEB1; Q9H2J0; Q9H3A3; Q9H5C9" "Ciliary landscape" "Neddylation" "2" "0" "1.019" "0.946" "0.941" "1.023" "0.956" "0.977" "1.029" "0.980" "0.823" "386.2" "393.6" "365.4" "363.2" "394.9" "369.2" "377.4" "397.3" "378.5" "317.8" "" "" "" "" "" "" "" "" "" "" "347.2" "318.5" "330.5" "354.6" "325.9" "369.2" "282.6" "350.9" "338.7" "113.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8994364974169992098" "False" "High" "IsMasterProtein" "Q6PIJ6" "F-box only protein 38 OS=Homo sapiens OX=9606 GN=FBXO38 PE=1 SV=3" "0.000" "False" "20.226" "7" "8" "8" "8" "1188" "133.9" "6.33" "26.14" "8" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf00646" "81545" "ENSG00000145868" "FBXO38" "hsa:81545; Q6PIJ6; Q6PK72; Q7Z2U0; Q86VN3; Q9BXY6; Q9H837; Q9HC40" "" "" "0" "0" "1.001" "1.088" "0.862" "1.120" "1.031" "1.186" "1.036" "1.170" "0.993" "557.8" "558.3" "607.0" "481.1" "625.0" "575.0" "661.8" "577.7" "652.6" "554.2" "" "" "" "" "" "" "" "" "" "" "501.5" "451.7" "549.1" "469.6" "515.7" "575.0" "495.5" "510.3" "583.9" "197.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3870745537767616027" "False" "High" "IsMasterProtein" "Q9UKT9" "Zinc finger protein Aiolos OS=Homo sapiens OX=9606 GN=IKZF3 PE=1 SV=2" "0.000" "False" "20.217" "15" "8" "9" "4" "509" "58.0" "6.55" "20.62" "8" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "22806" "ENSG00000161405" "IKZF3" "B4DVV5; hsa:22806; Q69BL6; Q69BL7; Q69BL8; Q69BL9; Q69BM0; Q69BM1; Q69BM2; Q69BM3; Q69BM5; Q8N574; Q8WWQ9; Q8WWR0; Q8WWR1; Q8WWR2; Q8WWR3; Q9UKT9" "17q12 copy number variation syndrome" "" "1" "0" "1.000" "0.957" "0.864" "1.030" "1.003" "0.980" "0.946" "0.961" "1.499" "526.1" "526.0" "503.6" "454.7" "542.1" "527.8" "515.8" "497.7" "505.8" "788.7" "" "" "" "" "" "" "" "" "" "" "473.0" "425.6" "455.5" "443.8" "447.4" "527.8" "386.2" "439.6" "452.5" "281.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3194956700439507601" "False" "High" "IsMasterProtein" "Q9UPT5" "Exocyst complex component 7 OS=Homo sapiens OX=9606 GN=EXOC7 PE=1 SV=3" "0.000" "False" "20.187" "9" "6" "8" "6" "735" "83.3" "6.79" "25.15" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf03081, Pf20669" "23265" "ENSG00000182473" "EXOC7" "B5MC69; B8XXP2; hsa:23265; Q8ND93; Q8WV91; Q96FF0; Q9H8C3; Q9H9X3; Q9HA32; Q9UPT5" "Angiopoietin-like protein 8 regulatory pathway; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "1.124" "1.112" "1.014" "1.127" "1.086" "1.071" "1.011" "1.085" "1.590" "369.3" "415.2" "410.5" "374.6" "416.2" "401.2" "395.3" "373.2" "400.7" "587.0" "" "" "" "" "" "" "" "" "" "" "332.0" "336.0" "371.3" "365.7" "343.4" "401.2" "296.0" "329.7" "358.5" "209.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1465801585106187641" "False" "High" "IsMasterProtein" "P52735" "Guanine nucleotide exchange factor VAV2 OS=Homo sapiens OX=9606 GN=VAV2 PE=1 SV=2" "0.000" "False" "20.151" "9" "7" "7" "7" "878" "101.2" "7.08" "23.28" "7" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00130, Pf00169, Pf00307, Pf00621, Pf07653" "7410" "ENSG00000160293" "VAV2" "A2RUM4; A8MQ12; B6ZDF5; hsa:7410; P52735; Q5SYV3; Q5SYV4; Q5SYV5; Q6N012; Q6PIJ9; Q6Q317" "Integrin-mediated cell adhesion; Prolactin signaling pathway; B cell receptor signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Focal adhesion; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Microglia pathogen phagocytosis pathway; Ebola virus infection in host; EGF/EGFR signaling pathway; 16p11.2 distal deletion syndrome; GDNF signaling" "EPH-ephrin mediated repulsion of cells; Regulation of actin dynamics for phagocytic cup formation; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; FCGR3A-mediated phagocytosis; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; GPVI-mediated activation cascade; DAP12 signaling; Signal transduction by L1; Azathioprine ADME; VEGFR2 mediated vascular permeability" "34" "0" "1.005" "1.097" "0.989" "1.005" "0.980" "1.056" "1.015" "1.025" "2.303" "351.5" "353.3" "385.7" "347.5" "353.4" "344.3" "371.1" "356.8" "360.4" "809.4" "" "" "" "" "" "" "" "" "" "" "316.0" "285.9" "348.9" "339.2" "291.6" "344.3" "277.9" "315.1" "322.4" "288.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153257875265109999" "False" "High" "IsMasterProtein" "Q9NYJ1" "Cytochrome c oxidase assembly factor 4 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA4 PE=1 SV=2" "0.000" "False" "20.144" "29" "3" "5" "3" "87" "10.1" "6.04" "23.35" "3" "cell organization and biogenesis" "mitochondrion" "" "Pf06747" "51287" "ENSG00000181924" "COA4" "B2RAA0; hsa:51287; Q69YU4; Q9NYJ1" "" "Mitochondrial protein import" "1" "0" "0.927" "1.029" "0.890" "0.981" "1.008" "1.019" "0.982" "0.943" "0.715" "613.3" "568.3" "631.0" "546.0" "601.4" "618.5" "625.0" "602.5" "578.4" "438.4" "" "" "" "" "" "" "" "" "" "" "551.4" "459.8" "570.8" "533.0" "496.2" "618.5" "468.0" "532.2" "517.6" "156.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9059271771169400119" "False" "High" "IsMasterProtein" "Q9UBK9" "Protein UXT OS=Homo sapiens OX=9606 GN=UXT PE=1 SV=1" "0.000" "False" "20.137" "25" "4" "8" "4" "157" "18.2" "7.59" "28.18" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02996" "8409" "ENSG00000126756" "UXT" "A0A0C4DFR8; B2R561; hsa:8409; Q5JZG3; Q9UBK9; Q9Y6E5" "" "Transcriptional Regulation by E2F6" "1" "0" "1.086" "1.041" "1.031" "1.104" "1.013" "1.059" "1.027" "1.120" "0.957" "332.9" "361.5" "346.5" "343.1" "367.7" "337.2" "352.6" "342.1" "373.0" "318.7" "" "" "" "" "" "" "" "" "" "" "299.3" "292.5" "313.4" "334.9" "303.4" "337.2" "264.0" "302.1" "333.8" "113.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5258302069466510735" "False" "High" "IsMasterProtein" "P56279" "T-cell leukemia/lymphoma protein 1A OS=Homo sapiens OX=9606 GN=TCL1A PE=1 SV=1" "0.000" "False" "20.135" "37" "4" "8" "4" "114" "13.5" "5.11" "26.40" "4" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01840" "8115" "ENSG00000100721" "TCL1A" "hsa:8115; P56279; Q6IBK7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "" "2" "0" "1.031" "0.938" "0.920" "1.123" "0.920" "1.021" "0.993" "0.868" "0.829" "261.4" "269.4" "245.1" "240.6" "293.6" "240.5" "266.9" "259.5" "227.0" "216.7" "" "" "" "" "" "" "" "" "" "" "235.0" "218.0" "221.7" "234.9" "242.3" "240.5" "199.9" "229.2" "203.1" "77.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4518403686067478951" "False" "High" "IsMasterProtein" "O95149" "Snurportin-1 OS=Homo sapiens OX=9606 GN=SNUPN PE=1 SV=1" "0.000" "False" "20.124" "19" "6" "9" "6" "360" "41.1" "6.64" "28.68" "6" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11538" "10073" "ENSG00000169371" "SNUPN" "A6NE34; A8K0B0; D3DW76; hsa:10073; O95149" "" "snRNP Assembly" "1" "0" "1.189" "1.039" "1.255" "1.037" "1.390" "1.107" "1.150" "1.087" "1.032" "1044.2" "1241.4" "1085.1" "1310.3" "1083.0" "1450.9" "1155.9" "1201.3" "1134.5" "1077.6" "" "" "" "" "" "" "" "" "" "" "938.8" "1004.5" "981.5" "1279.0" "893.7" "1450.9" "865.5" "1061.0" "1015.2" "384.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-710496043913301714" "False" "High" "IsMasterProtein" "Q15714" "TSC22 domain family protein 1 OS=Homo sapiens OX=9606 GN=TSC22D1 PE=1 SV=3" "0.000" "False" "20.123" "5" "6" "8" "3" "1073" "109.6" "5.64" "25.52" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf01166" "8848" "ENSG00000102804" "TSC22D1" "A0A087X0H8; B3KRL7; B9EGI0; hsa:8848; O00666; Q15714; Q6AHX5; Q6IBU1; Q8NCN1; Q96JS5" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "0" "1.053" "1.002" "1.013" "1.079" "1.012" "1.010" "1.074" "0.992" "0.935" "484.5" "510.0" "485.6" "491.0" "522.6" "490.1" "489.3" "520.4" "480.6" "453.0" "" "" "" "" "" "" "" "" "" "" "435.6" "412.6" "439.2" "479.3" "431.3" "490.1" "366.4" "459.6" "430.1" "161.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7736250579698754769" "False" "High" "IsMasterProtein" "Q8IV53" "DENN domain-containing protein 1C OS=Homo sapiens OX=9606 GN=DENND1C PE=1 SV=1" "0.000" "False" "20.112" "11" "6" "6" "6" "801" "87.0" "5.67" "23.66" "6" "transport" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "79958" "ENSG00000205744" "DENND1C" "B4E051; D3PFD4; hsa:79958; Q8IV53; Q8NDB1; Q9H5Z2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.048" "1.034" "1.027" "1.152" "1.097" "1.120" "1.031" "1.062" "1.996" "266.5" "279.4" "275.5" "273.6" "307.0" "292.4" "298.6" "274.7" "283.2" "532.0" "" "" "" "" "" "" "" "" "" "" "239.6" "226.1" "249.2" "267.1" "253.3" "292.4" "223.6" "242.6" "253.4" "189.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-981252296573627161" "False" "High" "IsMasterProtein" "Q8NCN4" "E3 ubiquitin-protein ligase RNF169 OS=Homo sapiens OX=9606 GN=RNF169 PE=1 SV=2" "0.000" "False" "20.085" "9" "7" "7" "7" "708" "77.1" "9.10" "18.93" "7" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13920" "254225" "ENSG00000166439" "RNF169" "hsa:254225; Q6N015; Q8NCN4" "" "" "0" "0" "1.127" "1.322" "1.074" "1.116" "1.185" "1.298" "1.099" "1.086" "1.314" "242.9" "273.6" "321.2" "260.8" "271.1" "287.8" "315.3" "266.8" "263.7" "319.2" "" "" "" "" "" "" "" "" "" "" "218.4" "221.4" "290.5" "254.6" "223.7" "287.8" "236.1" "235.7" "236.0" "113.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4776370304497058949" "False" "High" "IsMasterProtein" "Q8IV04" "Carabin OS=Homo sapiens OX=9606 GN=TBC1D10C PE=1 SV=1" "0.000" "False" "20.072" "16" "6" "8" "6" "446" "49.7" "8.76" "25.35" "6" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity" "Pf00566" "374403" "ENSG00000175463" "TBC1D10C" "G3V1D6; hsa:374403; Q8IV04" "" "Neutrophil degranulation; TBC/RABGAPs" "2" "0" "1.082" "1.014" "0.915" "1.182" "0.993" "1.096" "1.078" "1.053" "1.054" "368.7" "399.0" "373.9" "337.4" "435.9" "366.3" "404.1" "397.5" "388.3" "388.5" "" "" "" "" "" "" "" "" "" "" "331.5" "322.9" "338.3" "329.4" "359.7" "366.3" "302.6" "351.1" "347.5" "138.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3065352799485715425" "False" "High" "IsMasterProtein" "Q9P0P0" "E3 ubiquitin-protein ligase RNF181 OS=Homo sapiens OX=9606 GN=RNF181 PE=1 SV=1" "0.000" "False" "20.067" "45" "6" "8" "6" "153" "17.9" "5.06" "26.57" "6" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf13639" "51255" "ENSG00000168894" "RNF181" "hsa:51255; Q53H81; Q9P0P0" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "0.946" "1.080" "0.919" "0.967" "1.078" "0.986" "0.974" "1.053" "0.919" "726.7" "687.6" "784.6" "667.9" "702.5" "783.7" "716.6" "708.1" "765.1" "668.2" "" "" "" "" "" "" "" "" "" "" "653.4" "556.4" "709.7" "651.9" "579.8" "783.7" "536.6" "625.4" "684.6" "238.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687201697740038391" "False" "High" "IsMasterProtein" "Q9NP92" "Large ribosomal subunit protein mL65 OS=Homo sapiens OX=9606 GN=MRPS30 PE=1 SV=2" "0.000" "False" "20.056" "16" "6" "6" "6" "439" "50.3" "7.97" "24.43" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "10884" "ENSG00000112996" "MRPS30" "hsa:10884; Q96I91; Q96Q19; Q9H0P8; Q9NP92; Q9NSF9; Q9NZ76" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.009" "1.059" "1.001" "1.064" "0.950" "1.004" "1.023" "1.081" "1.092" "506.1" "510.7" "536.2" "506.7" "538.7" "480.8" "508.4" "517.7" "547.2" "552.9" "" "" "" "" "" "" "" "" "" "" "455.1" "413.2" "485.0" "494.6" "444.6" "480.8" "380.7" "457.3" "489.7" "197.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8998736333335138172" "False" "High" "IsMasterProtein" "Q08623" "Pseudouridine-5'-phosphatase OS=Homo sapiens OX=9606 GN=PUDP PE=1 SV=3" "0.000" "False" "20.036" "24" "4" "8" "4" "228" "25.2" "5.31" "26.52" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf13419" "8226" "ENSG00000130021" "PUDP" "B2R7X6; B4DV93; B7Z6Q3; E9PAV8; F5GWZ2; hsa:8226; Q08623; Q53F84; Q96EB8" "" "Pyrimidine salvage" "1" "0" "0.958" "0.909" "0.962" "1.044" "0.953" "1.048" "0.997" "0.951" "0.774" "679.7" "651.4" "617.6" "653.6" "709.8" "647.8" "712.3" "677.4" "646.3" "526.2" "" "" "" "" "" "" "" "" "" "" "611.1" "527.1" "558.6" "638.0" "585.7" "647.8" "533.3" "598.4" "578.3" "187.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6385362476021457625" "False" "High" "IsMasterProtein" "B3KNS4" "Endogenous retrovirus group K3 member 1 OS=Homo sapiens OX=9606 GN=ERVK3-1 PE=1 SV=1" "0.000" "False" "19.973" "39" "3" "6" "3" "109" "11.6" "7.78" "21.03" "3" "" "" "" "Pf15695" "" "ENSG00000142396" "ERVK3-1" "B3KNS4" "" "" "0" "0" "1.087" "1.020" "0.965" "1.042" "1.057" "0.982" "1.095" "1.029" "0.830" "413.9" "450.0" "422.2" "399.3" "431.2" "437.6" "406.3" "453.0" "426.1" "343.5" "" "" "" "" "" "" "" "" "" "" "372.1" "364.1" "381.9" "389.8" "355.8" "437.6" "304.2" "400.2" "381.2" "122.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "167158526121610019" "False" "High" "IsMasterProtein" "Q9UPW5" "Cytosolic carboxypeptidase 1 OS=Homo sapiens OX=9606 GN=AGTPBP1 PE=1 SV=3" "0.000" "False" "19.963" "5" "7" "8" "7" "1226" "138.4" "6.15" "24.52" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "23287" "ENSG00000135049" "AGTPBP1" "B4DIT6; B4DRZ8; hsa:23287; Q5VV80; Q63HM7; Q658P5; Q6P9D6; Q9H8U6; Q9H9W8; Q9NVK1; Q9UPW5" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "0.969" "0.959" "0.939" "0.966" "0.904" "0.972" "0.953" "0.968" "1.032" "572.2" "554.2" "548.9" "537.1" "553.0" "517.5" "556.1" "545.5" "554.0" "590.5" "" "" "" "" "" "" "" "" "" "" "514.5" "448.5" "496.5" "524.3" "456.4" "517.5" "416.4" "481.9" "495.7" "210.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5616510837335031809" "False" "High" "IsMasterProtein" "P15586" "N-acetylglucosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GNS PE=1 SV=3" "0.000" "False" "19.963" "11" "6" "7" "6" "552" "62.0" "8.31" "24.30" "6" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00884" "2799" "ENSG00000135677" "GNS" "B4DYH8; hsa:2799; P15586; Q53F05" "Glycosaminoglycan degradation" "Neutrophil degranulation; Lysosome Vesicle Biogenesis; Keratan sulfate degradation; MPS IIID - Sanfilippo syndrome D" "5" "0" "0.983" "1.007" "1.007" "1.069" "0.986" "0.992" "1.029" "1.038" "0.829" "688.1" "676.3" "692.8" "692.9" "735.7" "678.2" "682.8" "707.8" "714.2" "570.2" "" "" "" "" "" "" "" "" "" "" "618.7" "547.2" "626.6" "676.4" "607.1" "678.2" "511.3" "625.2" "639.0" "203.5" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6567734872650185245" "False" "High" "IsMasterProtein" "C9JLW8" "Mapk-regulated corepressor-interacting protein 1 OS=Homo sapiens OX=9606 GN=MCRIP1 PE=1 SV=1" "0.000" "False" "19.949" "51" "4" "6" "4" "97" "10.9" "9.41" "25.14" "4" "other biological processes" "nucleus;other cell component" "" "Pf14799" "348262" "ENSG00000225663; ENSG00000288213" "MCRIP1" "C9JLW8; hsa:348262; Q6ZUL0" "" "" "0" "0" "0.909" "0.937" "1.003" "0.975" "0.943" "0.965" "0.965" "0.940" "0.829" "532.8" "484.0" "499.2" "534.2" "519.5" "502.3" "514.1" "514.1" "500.7" "441.9" "" "" "" "" "" "" "" "" "" "" "479.0" "391.7" "451.6" "521.5" "428.7" "502.3" "385.0" "454.0" "448.0" "157.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2898803308841595735" "False" "High" "IsMasterProtein" "O00182" "Galectin-9 OS=Homo sapiens OX=9606 GN=LGALS9 PE=1 SV=2" "0.000" "False" "19.940" "16" "5" "7" "5" "355" "39.5" "9.17" "29.06" "5" "stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "other molecular function" "Pf00337" "3965" "ENSG00000168961" "LGALS9" "A7VJG6; F8W9W4; hsa:3965; O00182; O14532; O75028; Q3B8N1; Q53FQ0; Q8WYQ7; Q9NQ58" "Vitamin D receptor pathway; Pleural mesothelioma; Immune infiltration in pancreatic cancer" "Interleukin-2 family signaling" "4" "0" "1.216" "1.121" "1.034" "1.120" "1.136" "1.073" "1.090" "1.058" "0.877" "556.7" "676.7" "624.2" "575.7" "623.4" "632.1" "597.1" "607.0" "588.7" "488.4" "" "" "" "" "" "" "" "" "" "" "500.5" "547.6" "564.6" "562.0" "514.5" "632.1" "447.1" "536.1" "526.8" "174.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2713677220638239159" "False" "High" "IsMasterProtein" "Q7L099" "Protein RUFY3 OS=Homo sapiens OX=9606 GN=RUFY3 PE=1 SV=1" "0.000" "False" "19.931" "15" "7" "8" "6" "469" "52.9" "5.49" "18.27" "7" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;other cell component" "" "Pf02759" "22902" "ENSG00000018189" "RUFY3" "B3KM25; B4DYW7; D9N163; hsa:22902; O94948; Q7L099; Q9UI00" "" "" "0" "0" "1.032" "1.062" "0.966" "1.081" "1.060" "1.004" "0.980" "1.031" "1.264" "323.2" "333.6" "343.3" "312.1" "349.5" "342.5" "324.4" "316.8" "333.2" "408.6" "" "" "" "" "" "" "" "" "" "" "290.6" "269.9" "310.5" "304.6" "288.4" "342.5" "242.9" "279.8" "298.2" "145.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7441376780111574138" "False" "High" "IsMasterProtein" "Q96BS2" "Calcineurin B homologous protein 3 OS=Homo sapiens OX=9606 GN=TESC PE=1 SV=3" "0.000" "False" "19.910" "39" "7" "9" "7" "214" "24.7" "4.93" "30.12" "7" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf13405" "54997" "ENSG00000088992" "TESC" "F5H1Y5; hsa:54997; Q96BS2; Q9NWT9" "" "" "0" "0" "1.132" "0.948" "0.915" "1.247" "1.608" "1.135" "1.044" "1.440" "0.962" "322.1" "364.6" "305.4" "294.7" "401.8" "517.8" "365.6" "336.2" "463.9" "309.9" "" "" "" "" "" "" "" "" "" "" "289.6" "295.0" "276.2" "287.6" "331.5" "517.8" "273.7" "296.9" "415.1" "110.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9120565565592818035" "False" "High" "IsMasterProtein" "P23443" "Ribosomal protein S6 kinase beta-1 OS=Homo sapiens OX=9606 GN=RPS6KB1 PE=1 SV=2" "0.000" "False" "19.895" "14" "7" "8" "7" "525" "59.1" "6.65" "33.10" "7" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "6198" "ENSG00000108443" "RPS6KB1" "B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1; hsa:6198; P23443; Q7Z721" "IL-5 signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Kit receptor signaling pathway; IL6 signaling pathway; BDNF-TrkB signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Gastrin signaling pathway; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; Cytoplasmic ribosomal proteins; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Pleural mesothelioma; GDNF signaling; G13 signaling pathway; Acute myeloid leukemia; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; ErbB signaling pathway" "mTORC1-mediated signalling" "42" "0" "0.908" "0.950" "0.929" "0.999" "0.926" "0.775" "0.832" "1.022" "0.748" "432.3" "392.3" "410.7" "401.7" "431.8" "400.3" "335.2" "359.5" "441.9" "323.3" "" "" "" "" "" "" "" "" "" "" "388.7" "317.4" "371.5" "392.1" "356.3" "400.3" "251.0" "317.5" "395.4" "115.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157541479094675987" "False" "High" "IsMasterProtein" "Q96AB3" "Isochorismatase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ISOC2 PE=1 SV=1" "0.000" "False" "19.887" "18" "2" "9" "2" "205" "22.3" "7.77" "35.17" "2" "other biological processes" "nucleus;other cell component" "" "Pf00857" "79763" "ENSG00000063241" "ISOC2" "hsa:79763; Q6ZN91; Q96AB3; Q9H5G0" "" "" "0" "0" "1.083" "1.041" "1.032" "1.071" "1.131" "1.154" "1.137" "1.030" "0.801" "450.6" "488.1" "469.2" "465.0" "482.6" "509.7" "519.8" "512.3" "464.3" "360.9" "" "" "" "" "" "" "" "" "" "" "405.1" "394.9" "424.4" "453.9" "398.3" "509.7" "389.2" "452.5" "415.5" "128.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4607454407969117171" "False" "High" "IsMasterProtein" "A6NED2" "RCC1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCCD1 PE=1 SV=1" "0.000" "False" "19.855" "20" "5" "5" "5" "376" "40.1" "5.27" "22.69" "5" "cell organization and biogenesis" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf00415" "91433" "ENSG00000166965" "RCCD1" "A6NED2; B2RTP9; hsa:91433; Q29RX6" "" "Protein hydroxylation" "1" "0" "1.020" "0.931" "0.917" "0.928" "0.940" "0.910" "0.936" "0.949" "1.003" "428.1" "436.7" "398.5" "392.6" "397.4" "402.4" "389.4" "400.5" "406.1" "429.3" "" "" "" "" "" "" "" "" "" "" "384.9" "353.3" "360.5" "383.2" "327.9" "402.4" "291.6" "353.8" "363.4" "153.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "745274347307830124" "False" "High" "IsMasterProtein" "Q9BX70" "BTB/POZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=BTBD2 PE=1 SV=1" "0.000" "False" "19.841" "13" "6" "6" "6" "525" "55.9" "5.90" "23.89" "6" "developmental processes" "cytosol;other cell component" "" "Pf00651, Pf07707, Pf08005" "55643" "ENSG00000133243" "BTBD2" "hsa:55643; O60418; O75248; Q4VBZ1; Q6IAC5; Q7Z5W0; Q96SX8; Q9BX70; Q9NPS1; Q9NX81" "" "" "0" "0" "0.998" "0.967" "0.943" "1.017" "1.063" "0.997" "0.970" "1.023" "1.091" "414.6" "413.9" "401.1" "391.1" "421.7" "440.8" "413.3" "402.1" "424.1" "452.2" "" "" "" "" "" "" "" "" "" "" "372.8" "334.9" "362.9" "381.8" "348.0" "440.8" "309.5" "355.2" "379.5" "161.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457401366019025404" "False" "High" "IsMasterProtein" "Q7KZI7" "Serine/threonine-protein kinase MARK2 OS=Homo sapiens OX=9606 GN=MARK2 PE=1 SV=2" "0.000" "False" "19.810" "7" "5" "6" "2" "788" "87.9" "9.72" "21.78" "5" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00627, Pf02149" "2011" "ENSG00000072518" "MARK2" "hsa:2011; Q15449; Q15524; Q5XGA3; Q68A18; Q7KZI7; Q96HB3; Q96RG0" "Microtubule cytoskeleton regulation; Complement system in neuronal development and plasticity; Neurogenesis regulation in the olfactory epithelium" "" "3" "0" "1.183" "1.192" "1.038" "1.244" "1.148" "1.020" "1.183" "1.183" "1.450" "128.5" "152.0" "153.1" "133.3" "159.9" "147.5" "131.0" "152.0" "152.0" "186.2" "" "" "" "" "" "" "" "" "" "" "115.5" "123.0" "138.5" "130.2" "131.9" "147.5" "98.1" "134.3" "136.0" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966117974293097362" "False" "High" "IsMasterProtein" "Q9UHL4" "Dipeptidyl peptidase 2 OS=Homo sapiens OX=9606 GN=DPP7 PE=1 SV=3" "0.000" "False" "19.808" "14" "6" "6" "6" "492" "54.3" "6.32" "21.65" "6" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "29952" "ENSG00000176978" "DPP7" "A8K7U7; hsa:29952; Q5VSF1; Q969X4; Q9UHL4" "" "Neutrophil degranulation" "1" "0" "1.187" "1.107" "1.060" "1.260" "1.262" "1.148" "1.192" "1.193" "1.087" "137.7" "163.5" "152.4" "146.1" "173.6" "173.8" "158.2" "164.2" "164.3" "149.7" "" "" "" "" "" "" "" "" "" "" "123.8" "132.3" "137.9" "142.6" "143.2" "173.8" "118.4" "145.1" "147.0" "53.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2198906581928094734" "False" "High" "IsMasterProtein" "Q9BQC3" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 OS=Homo sapiens OX=9606 GN=DPH2 PE=1 SV=1" "0.000" "False" "19.801" "14" "6" "7" "6" "489" "52.1" "5.53" "27.04" "6" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf01866" "1802" "ENSG00000132768" "DPH2" "A8MVC9; B2RDE3; B4DNI8; hsa:1802; O60623; Q9BQC3" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.034" "1.010" "0.956" "1.072" "1.013" "1.059" "1.030" "1.001" "0.911" "668.6" "691.5" "675.6" "639.2" "716.6" "677.1" "707.8" "689.0" "669.3" "609.1" "" "" "" "" "" "" "" "" "" "" "601.2" "559.5" "611.1" "623.9" "591.4" "677.1" "530.0" "608.6" "598.9" "217.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4722809731006219467" "False" "High" "IsMasterProtein" "P48047" "ATP synthase subunit O, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PO PE=1 SV=1" "0.000" "False" "19.776" "22" "4" "5" "4" "213" "23.3" "9.96" "22.34" "4" "other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion" "transporter activity" "Pf00213" "539" "ENSG00000241837" "ATP5PO" "B2R4E2; hsa:539; P48047; Q5U042; Q6IBI2" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "6" "0" "0.995" "0.990" "0.977" "0.976" "0.960" "1.028" "0.966" "1.004" "1.184" "275.5" "274.1" "272.7" "269.2" "268.9" "264.5" "283.2" "266.2" "276.7" "326.3" "" "" "" "" "" "" "" "" "" "" "247.7" "221.8" "246.7" "262.8" "221.9" "264.5" "212.1" "235.1" "247.6" "116.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1051974243482830997" "False" "High" "IsMasterProtein" "P21127" "Cyclin-dependent kinase 11B OS=Homo sapiens OX=9606 GN=CDK11B PE=1 SV=4" "0.000" "False" "19.736" "10" "8" "9" "8" "795" "92.6" "5.54" "24.83" "8" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "984" "ENSG00000248333" "CDK11B" "B7ZVY7; hsa:984; J3KTL7; J3QR29; J3QR44; O95265; P21127; Q12817; Q12818; Q12819; Q12820; Q12822; Q8N530; Q9NZS5; Q9UBJ0; Q9UBQ1; Q9UBR0; Q9UNY2; Q9UP57; Q9UP58; Q9UP59" "1p36 copy number variation syndrome" "Recruitment of mitotic centrosome proteins and complexes" "2" "0" "0.893" "0.953" "0.847" "0.871" "0.958" "0.917" "0.832" "0.887" "0.661" "287.8" "257.1" "274.3" "243.8" "250.8" "275.6" "263.9" "239.5" "255.2" "190.3" "" "" "" "" "" "" "" "" "" "" "258.7" "208.0" "248.1" "237.9" "206.9" "275.6" "197.6" "211.5" "228.3" "67.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8981469479003528624" "False" "High" "IsMasterProtein" "Q9BZE1" "Large ribosomal subunit protein mL37 OS=Homo sapiens OX=9606 GN=MRPL37 PE=1 SV=2" "0.000" "False" "19.726" "16" "5" "6" "5" "423" "48.1" "8.59" "21.85" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf07147" "51253" "ENSG00000116221" "MRPL37" "hsa:51253; Q96Q67; Q9BWR1; Q9BZE1; Q9P0P3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.030" "0.924" "1.039" "1.000" "0.955" "1.096" "1.008" "1.040" "1.431" "432.7" "445.7" "399.8" "449.7" "432.8" "413.1" "474.0" "436.1" "450.0" "619.2" "" "" "" "" "" "" "" "" "" "" "389.0" "360.6" "361.6" "438.9" "357.1" "413.1" "354.9" "385.2" "402.7" "221.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4713550819086734085" "False" "High" "IsMasterProtein" "Q96AT9" "Ribulose-phosphate 3-epimerase OS=Homo sapiens OX=9606 GN=RPE PE=1 SV=1" "0.000" "False" "19.723" "24" "4" "6" "4" "228" "24.9" "5.58" "30.02" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00834" "6120" "ENSG00000197713" "RPE" "A8K4S0; B4E016; C9JPQ7; hsa:6120; O43767; Q53TV9; Q8N215; Q96AT9; Q96N34; Q9BSB5" "Pentose phosphate metabolism; Pentose phosphate pathway in senescent cells" "Pentose phosphate pathway" "3" "0" "1.052" "0.951" "0.941" "0.999" "1.013" "0.998" "1.006" "0.970" "0.838" "491.3" "516.6" "467.3" "462.4" "490.6" "497.6" "490.2" "494.2" "476.4" "411.6" "" "" "" "" "" "" "" "" "" "" "441.7" "418.0" "422.7" "451.4" "404.9" "497.6" "367.0" "436.5" "426.2" "146.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7428234003778738305" "False" "High" "IsMasterProtein" "Q9BRT2" "Ubiquinol-cytochrome c reductase complex assembly factor 2 OS=Homo sapiens OX=9606 GN=UQCC2 PE=1 SV=1" "0.000" "False" "19.722" "34" "4" "7" "4" "126" "14.9" "7.37" "27.20" "4" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf20180" "84300" "ENSG00000137288" "UQCC2" "B2R4I0; Q9BRT2" "Mitochondrial complex III assembly" "" "1" "0" "0.893" "1.007" "0.966" "0.992" "1.017" "0.973" "0.999" "1.095" "0.997" "902.6" "806.2" "908.7" "871.8" "895.8" "917.9" "878.2" "901.6" "988.6" "899.9" "" "" "" "" "" "" "" "" "" "" "811.5" "652.4" "822.0" "851.0" "739.2" "917.9" "657.6" "796.4" "884.6" "321.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3824226989303919527" "False" "High" "IsMasterProtein" "Q68EM7" "Rho GTPase-activating protein 17 OS=Homo sapiens OX=9606 GN=ARHGAP17 PE=1 SV=1" "0.000" "False" "19.718" "8" "6" "6" "6" "881" "95.4" "7.62" "22.92" "6" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00620, Pf03114" "55114" "ENSG00000140750; ENSG00000288353" "ARHGAP17" "A8K6M6; hsa:55114; Q68EM7; Q6ZUS4; Q7Z2F2; Q8NDG2; Q96KS2; Q96KS3; Q96SS8; Q9BVF6; Q9H8U5; Q9NW54" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "6" "0" "1.090" "1.062" "0.926" "1.112" "1.009" "1.129" "1.028" "1.025" "1.586" "458.1" "499.4" "486.6" "424.3" "509.5" "462.0" "517.3" "471.0" "469.4" "726.6" "" "" "" "" "" "" "" "" "" "" "411.8" "404.1" "440.2" "414.2" "420.4" "462.0" "387.3" "416.0" "420.0" "259.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6467566476375476721" "False" "High" "IsMasterProtein" "Q03154" "Aminoacylase-1 OS=Homo sapiens OX=9606 GN=ACY1 PE=1 SV=1" "0.000" "False" "19.713" "20" "8" "8" "8" "408" "45.9" "6.18" "24.07" "8" "other metabolic processes" "non-structural extracellular;cytosol" "other molecular function" "Pf01546, Pf07687" "95" "ENSG00000243989" "ACY1" "C9J6I6; C9J9D8; C9JWD4; hsa:95; Q03154" "Thyroxine (thyroid hormone) production" "Aflatoxin activation and detoxification; Paracetamol ADME; Defective ACY1 causes encephalopathy" "4" "0" "1.026" "0.998" "1.006" "1.073" "1.016" "1.050" "0.959" "0.971" "0.835" "895.3" "918.6" "893.7" "900.3" "960.4" "909.6" "940.5" "859.0" "869.3" "747.7" "" "" "" "" "" "" "" "" "" "" "804.9" "743.3" "808.4" "878.8" "792.6" "909.6" "704.2" "758.7" "777.8" "266.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "538564902379484332" "False" "High" "IsMasterProtein" "P49815" "Tuberin OS=Homo sapiens OX=9606 GN=TSC2 PE=1 SV=2" "0.000" "False" "19.710" "3" "6" "6" "6" "1807" "200.5" "7.31" "17.08" "6" "stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf03542, Pf11864" "7249" "ENSG00000103197" "TSC2" "A7E2E2; B4DIL8; B4DIQ7; B4DRN2; B7Z2B8; C9J378; hsa:7249; O75275; P49815; Q4LE71; Q8TAZ1" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Follicle stimulating hormone (FSH) signaling pathway; Glioblastoma signaling pathways; Brain-derived neurotrophic factor (BDNF) signaling pathway; Nanoparticle triggered autophagic cell death; Polycystic kidney disease pathway; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; ATM signaling in development and disease ; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Thermogenesis; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; Insulin signaling; p53 transcriptional gene network; Pleural mesothelioma; DYRK1A involvement regarding cell proliferation in brain development; Primary ovarian insufficiency; Monoamine transport" "Constitutive Signaling by AKT1 E17K in Cancer; TP53 Regulates Metabolic Genes; AKT phosphorylates targets in the cytosol; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; TBC/RABGAPs; Inhibition of TSC complex formation by PKB" "35" "0" "0.949" "0.851" "0.936" "0.956" "0.821" "0.971" "0.908" "0.860" "1.406" "431.1" "409.2" "367.1" "403.3" "412.3" "353.8" "418.6" "391.6" "370.8" "606.3" "" "" "" "" "" "" "" "" "" "" "387.6" "331.1" "332.0" "393.7" "340.3" "353.8" "313.5" "345.9" "331.8" "216.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4043676364934071043" "False" "High" "IsMasterProtein" "Q14254" "Flotillin-2 OS=Homo sapiens OX=9606 GN=FLOT2 PE=1 SV=2" "0.000" "False" "19.709" "14" "6" "7" "6" "428" "47.0" "5.25" "23.25" "6" "cell adhesion;transport;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "" "Pf01145" "2319" "ENSG00000132589" "FLOT2" "hsa:2319; Q14254" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "Regulation of necroptotic cell death; RND1 GTPase cycle; RHOB GTPase cycle; RND3 GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; Synaptic adhesion-like molecules" "10" "0" "1.081" "1.016" "1.094" "1.161" "1.114" "1.092" "1.027" "1.065" "1.041" "389.0" "420.8" "395.4" "425.5" "451.7" "433.3" "424.7" "399.7" "414.3" "405.1" "" "" "" "" "" "" "" "" "" "" "349.8" "340.5" "357.7" "415.3" "372.8" "433.3" "318.0" "353.0" "370.7" "144.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697873925504819237" "False" "High" "IsMasterProtein" "P50053" "Ketohexokinase OS=Homo sapiens OX=9606 GN=KHK PE=1 SV=2" "0.000" "False" "19.706" "26" "7" "9" "7" "298" "32.5" "6.32" "27.51" "7" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00294" "3795" "ENSG00000138030" "KHK" "hsa:3795; P50053; Q6IBK2; Q99532; Q9BRJ3; Q9UMN1" "Disorders of fructose metabolism; Polyol pathway" "Fructose catabolism; Essential fructosuria" "4" "0" "0.846" "0.946" "1.000" "0.874" "0.881" "1.077" "1.018" "0.941" "0.912" "192.6" "163.1" "182.2" "192.6" "168.4" "169.8" "207.5" "196.2" "181.2" "175.7" "" "" "" "" "" "" "" "" "" "" "173.2" "131.9" "164.8" "188.0" "139.0" "169.8" "155.3" "173.3" "162.1" "62.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293840026169595064" "False" "High" "IsMasterProtein" "Q6ZVK8" "8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens OX=9606 GN=NUDT18 PE=1 SV=3" "0.000" "False" "19.694" "25" "6" "7" "6" "323" "35.5" "6.23" "25.41" "6" "other metabolic processes" "cytosol" "other molecular function" "Pf00293" "79873" "ENSG00000275074" "NUDT18" "hsa:79873; Q6ZVK8; Q8IZ75; Q9H687" "" "" "0" "0" "0.997" "0.976" "0.945" "1.083" "0.997" "1.008" "0.940" "0.941" "0.920" "146.7" "146.2" "143.2" "138.6" "158.8" "146.2" "147.8" "137.9" "138.0" "135.0" "" "" "" "" "" "" "" "" "" "" "131.9" "118.3" "129.5" "135.3" "131.0" "146.2" "110.7" "121.8" "123.5" "48.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2862738582169560407" "False" "High" "IsMasterProtein" "Q9H3S1" "Semaphorin-4A OS=Homo sapiens OX=9606 GN=SEMA4A PE=1 SV=2" "0.000" "False" "19.673" "7" "5" "6" "5" "761" "83.5" "6.84" "21.07" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "64218" "ENSG00000196189" "SEMA4A" "B2RDH8; B3KR76; hsa:64218; Q5TCI5; Q5TCJ6; Q8WUA9; Q9H3S1" "Neurogenesis regulation in the olfactory epithelium" "Other semaphorin interactions" "2" "0" "1.106" "1.149" "1.039" "1.133" "1.056" "0.992" "1.027" "1.095" "0.871" "264.7" "292.8" "304.1" "275.1" "299.9" "279.6" "262.7" "271.9" "290.0" "230.5" "" "" "" "" "" "" "" "" "" "" "238.0" "236.9" "275.0" "268.5" "247.5" "279.6" "196.7" "240.1" "259.5" "82.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5319872679741064952" "False" "High" "IsMasterProtein" "P22570" "NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Homo sapiens OX=9606 GN=FDXR PE=1 SV=3" "0.000" "False" "19.669" "14" "7" "8" "7" "491" "53.8" "8.44" "22.90" "7" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf07992" "2232" "ENSG00000161513" "FDXR" "B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1; hsa:2232; P22570; Q13716; Q4PJI0; Q9BU12" "Iron-sulfur cluster biogenesis" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "1.029" "1.090" "0.959" "0.999" "1.262" "1.163" "1.097" "1.032" "1.094" "365.4" "375.9" "398.2" "350.6" "364.9" "461.3" "425.0" "400.9" "377.3" "399.6" "" "" "" "" "" "" "" "" "" "" "328.5" "304.2" "360.2" "342.2" "301.1" "461.3" "318.2" "354.1" "337.6" "142.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7333138879338488080" "False" "High" "IsMasterProtein" "Q9GZM8" "Nuclear distribution protein nudE-like 1 OS=Homo sapiens OX=9606 GN=NDEL1 PE=1 SV=1" "0.000" "False" "19.668" "14" "5" "8" "1" "345" "38.4" "5.24" "30.12" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf04880" "81565" "ENSG00000166579" "NDEL1" "B3KP93; D3DTS0; hsa:81565; J3QT32; Q86T80; Q8TAR7; Q9GZM8; Q9UH50" "Neurogenesis regulation in the olfactory epithelium; PAFAH1B1 copy number variation" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6594093010420554285" "False" "High" "IsMasterProtein" "Q9NWZ3" "Interleukin-1 receptor-associated kinase 4 OS=Homo sapiens OX=9606 GN=IRAK4 PE=1 SV=1" "0.000" "False" "19.660" "14" "7" "7" "7" "460" "51.5" "5.41" "22.47" "7" "other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "51135" "ENSG00000198001" "IRAK4" "hsa:51135; Q69FE1; Q8TDF7; Q9NWZ3; Q9Y589" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Toll-like receptor signaling pathway" "Interleukin-1 signaling; PIP3 activates AKT signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; IRAK4 deficiency (TLR2/4); PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "23" "0" "1.052" "1.029" "0.956" "1.036" "0.954" "1.075" "1.011" "1.001" "1.487" "768.5" "808.7" "791.0" "734.6" "796.4" "732.9" "826.2" "776.6" "769.4" "1142.4" "" "" "" "" "" "" "" "" "" "" "690.9" "654.4" "715.5" "717.1" "657.2" "732.9" "618.7" "685.9" "688.5" "407.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1135638411849566769" "False" "High" "IsMasterProtein" "O76021" "Ribosomal L1 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RSL1D1 PE=1 SV=3" "0.000" "False" "19.634" "15" "7" "8" "7" "490" "54.9" "10.13" "22.68" "7" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf00687" "26156" "ENSG00000171490" "RSL1D1" "B4DJ58; D3DUG7; hsa:26156; O76021; Q2M1T7; Q6PL22; Q8IWS7; Q8WUZ1; Q9HDA9; Q9Y3Z9" "" "" "0" "0" "1.039" "0.781" "0.902" "0.997" "0.788" "0.983" "0.944" "0.703" "0.685" "666.9" "692.7" "520.8" "601.7" "664.8" "525.6" "655.5" "629.7" "469.2" "457.1" "" "" "" "" "" "" "" "" "" "" "599.6" "560.5" "471.1" "587.3" "548.6" "525.6" "490.8" "556.2" "419.8" "163.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527678404860705700" "False" "High" "IsMasterProtein" "Q96K21" "Abscission/NoCut checkpoint regulator OS=Homo sapiens OX=9606 GN=ZFYVE19 PE=1 SV=3" "0.000" "False" "19.631" "12" "6" "7" "5" "471" "51.5" "5.73" "20.58" "6" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf01363" "84936" "ENSG00000166140" "ZFYVE19" "B3KVB2; C9JNF4; H3BUF9; hsa:84936; Q86WC2; Q8WU96; Q96K21" "" "" "0" "1" "0.998" "1.079" "0.950" "1.069" "1.124" "1.027" "1.040" "1.101" "0.882" "719.4" "717.8" "776.0" "683.6" "769.2" "808.9" "739.1" "748.5" "792.4" "634.7" "" "" "" "" "" "" "" "" "" "" "646.8" "580.8" "701.9" "667.3" "634.8" "808.9" "553.5" "661.2" "709.0" "226.6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1176718520801112015" "False" "High" "IsMasterProtein" "P11441" "Ubiquitin-like protein 4A OS=Homo sapiens OX=9606 GN=UBL4A PE=1 SV=1" "0.000" "False" "19.626" "26" "3" "6" "3" "157" "17.8" "8.66" "24.00" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00240, Pf17840" "8266" "ENSG00000102178" "UBL4A" "hsa:8266; P11441; Q5HY80" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "1.005" "0.976" "0.972" "0.931" "1.094" "1.086" "1.033" "0.967" "1.050" "353.7" "355.5" "345.1" "343.9" "329.4" "387.0" "384.2" "365.3" "342.2" "371.2" "" "" "" "" "" "" "" "" "" "" "318.0" "287.7" "312.2" "335.7" "271.8" "387.0" "287.7" "322.7" "306.2" "132.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4837224883862522345" "False" "High" "IsMasterProtein" "Q9BYD1" "Large ribosomal subunit protein uL13m OS=Homo sapiens OX=9606 GN=MRPL13 PE=1 SV=1" "0.000" "False" "19.610" "40" "6" "7" "6" "178" "20.7" "9.16" "31.36" "6" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00572" "28998" "ENSG00000172172" "MRPL13" "B2R4R8; hsa:28998; Q9BYD1; Q9UI04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.913" "0.929" "0.995" "0.990" "0.940" "1.070" "0.964" "0.972" "1.079" "703.8" "642.5" "654.1" "700.4" "697.0" "661.8" "753.0" "678.3" "683.8" "759.4" "" "" "" "" "" "" "" "" "" "" "632.8" "519.9" "591.6" "683.7" "575.2" "661.8" "563.9" "599.2" "611.9" "271.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7997158032231502372" "False" "High" "IsMasterProtein" "Q9Y6D9" "Mitotic spindle assembly checkpoint protein MAD1 OS=Homo sapiens OX=9606 GN=MAD1L1 PE=1 SV=2" "0.000" "False" "19.577" "9" "7" "7" "7" "718" "83.0" "5.92" "22.64" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05557" "8379" "ENSG00000002822" "MAD1L1" "B3KR41; hsa:8379; Q13312; Q75MI0; Q86UM4; Q9UNH0; Q9Y6D9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; Pleural mesothelioma; CCL18 signaling pathway" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "10" "0" "1.047" "1.059" "0.951" "1.114" "1.083" "1.150" "1.081" "1.074" "3.493" "409.4" "428.7" "433.5" "389.3" "456.0" "443.3" "470.6" "442.8" "439.5" "1430.1" "" "" "" "" "" "" "" "" "" "" "368.1" "346.9" "392.1" "380.0" "376.3" "443.3" "352.4" "391.1" "393.3" "510.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5100891898626735389" "False" "High" "IsMasterProtein" "Q86WA6" "Valacyclovir hydrolase OS=Homo sapiens OX=9606 GN=BPHL PE=1 SV=1" "0.000" "False" "19.572" "21" "7" "8" "7" "291" "32.5" "9.14" "24.57" "7" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00561" "670" "ENSG00000137274" "BPHL" "hsa:670; Q00306; Q13855; Q3KP51; Q86WA6" "" "Phase I - Functionalization of compounds" "1" "0" "1.063" "1.002" "0.969" "1.041" "0.909" "0.944" "1.019" "0.932" "0.766" "488.9" "519.7" "490.1" "473.9" "508.7" "444.5" "461.5" "498.0" "455.7" "374.7" "" "" "" "" "" "" "" "" "" "" "439.6" "420.5" "443.3" "462.6" "419.8" "444.5" "345.6" "439.8" "407.8" "133.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-115181160460478952" "False" "High" "IsMasterProtein" "P35754" "Glutaredoxin-1 OS=Homo sapiens OX=9606 GN=GLRX PE=1 SV=2" "0.000" "False" "19.565" "30" "2" "10" "2" "106" "11.8" "8.09" "53.71" "2" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00462" "2745" "ENSG00000173221" "GLRX" "B2R4L2; hsa:2745; P35754; Q3KQS1; Q6ICT1" "One-carbon metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.882" "0.934" "0.890" "0.962" "0.907" "0.949" "0.978" "0.922" "0.765" "1197.5" "1056.6" "1118.9" "1065.6" "1152.6" "1086.0" "1135.9" "1171.5" "1103.6" "916.3" "" "" "" "" "" "" "" "" "" "" "1076.7" "855.0" "1012.1" "1040.1" "951.1" "1086.0" "850.5" "1034.7" "987.5" "327.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3610986345004973856" "False" "High" "IsMasterProtein" "P82664" "Small ribosomal subunit protein uS10m OS=Homo sapiens OX=9606 GN=MRPS10 PE=1 SV=2" "0.000" "False" "19.564" "17" "3" "5" "3" "201" "23.0" "8.00" "20.85" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf00338" "55173" "ENSG00000048544" "MRPS10" "B2RE89; hsa:55173; P82664; Q9H3E5; Q9NVR3" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.953" "0.892" "0.939" "1.022" "0.920" "0.947" "0.840" "0.983" "1.575" "458.0" "436.7" "408.7" "430.2" "467.9" "421.5" "433.7" "384.8" "450.1" "721.6" "" "" "" "" "" "" "" "" "" "" "411.8" "353.3" "369.7" "419.9" "386.1" "421.5" "324.8" "339.9" "402.7" "257.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4594360635056461095" "False" "High" "IsMasterProtein" "O75648" "Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Homo sapiens OX=9606 GN=TRMU PE=1 SV=2" "0.000" "False" "19.553" "13" "5" "6" "5" "421" "47.7" "8.03" "17.74" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf03054, Pf20258, Pf20259" "55687" "ENSG00000100416" "TRMU" "A8K3U7; hsa:55687; O75648; Q05C99; Q5W9C8; Q66K31; Q6ICC3; Q9NWC1" "" "tRNA modification in the mitochondrion" "1" "0" "1.093" "1.143" "0.999" "1.186" "1.107" "1.068" "1.070" "1.134" "1.081" "491.9" "537.8" "562.2" "491.2" "583.2" "544.7" "525.4" "526.5" "557.6" "531.9" "" "" "" "" "" "" "" "" "" "" "442.3" "435.2" "508.5" "479.5" "481.3" "544.7" "393.4" "465.0" "499.0" "189.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8302627442796740728" "False" "High" "IsMasterProtein" "Q15771" "Ras-related protein Rab-30 OS=Homo sapiens OX=9606 GN=RAB30 PE=1 SV=2" "0.000" "False" "19.548" "31" "5" "14" "3" "203" "23.0" "4.97" "38.46" "5" "cell organization and biogenesis;transport;signal transduction" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00071" "27314" "ENSG00000137502" "RAB30" "hsa:27314; Q15771; Q6FGK1; Q6MZH2; Q96CI8" "" "Intra-Golgi traffic; RAB geranylgeranylation" "2" "0" "1.112" "1.153" "1.095" "1.195" "0.974" "1.014" "1.041" "1.361" "1.026" "148.3" "165.0" "171.1" "162.4" "177.2" "144.5" "150.4" "154.4" "201.9" "152.2" "" "" "" "" "" "" "" "" "" "" "133.4" "133.5" "154.7" "158.5" "146.3" "144.5" "112.6" "136.4" "180.7" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2244987817245821138" "False" "High" "IsMasterProtein" "Q14004" "Cyclin-dependent kinase 13 OS=Homo sapiens OX=9606 GN=CDK13 PE=1 SV=2" "0.000" "False" "19.547" "5" "6" "12" "4" "1512" "164.8" "9.69" "37.11" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8621" "ENSG00000065883" "CDK13" "hsa:8621; Q14004; Q53G78; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4" "" "Neutrophil degranulation; TP53 Regulates Transcription of DNA Repair Genes" "2" "0" "1.208" "0.908" "1.152" "1.137" "1.053" "1.323" "1.065" "1.211" "1.105" "83.7" "101.1" "76.0" "96.4" "95.2" "88.1" "110.7" "89.2" "101.4" "92.5" "" "" "" "" "" "" "" "" "" "" "75.3" "81.8" "68.8" "94.1" "78.5" "88.1" "82.9" "78.7" "90.7" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7653373487496169859" "False" "High" "IsMasterProtein" "Q4VC05" "B-cell CLL/lymphoma 7 protein family member A OS=Homo sapiens OX=9606 GN=BCL7A PE=1 SV=1" "0.000" "False" "19.527" "22" "6" "7" "3" "210" "22.8" "5.14" "20.87" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf04714" "605" "ENSG00000110987" "BCL7A" "B4DJN6; B7ZB21; hsa:605; Q13843; Q14CT7; Q4VC05" "" "" "0" "2" "0.822" "0.896" "0.900" "0.955" "0.866" "0.945" "1.003" "0.868" "1.223" "784.9" "644.9" "703.5" "706.3" "749.6" "680.1" "742.1" "787.6" "681.1" "960.2" "" "" "" "" "" "" "" "" "" "" "705.7" "521.8" "636.4" "689.5" "618.6" "680.1" "555.6" "695.7" "609.5" "342.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3526658263404779392" "False" "High" "IsMasterProtein" "Q9UBI1" "COMM domain-containing protein 3 OS=Homo sapiens OX=9606 GN=COMMD3 PE=1 SV=1" "0.000" "False" "19.494" "28" "4" "5" "4" "195" "22.1" "5.99" "20.84" "4" "transport" "non-structural extracellular;nucleus;other cell component" "" "Pf07258" "23412" "ENSG00000148444" "COMMD3" "D3DRU7; hsa:23412; Q5T8Y9; Q9UBI1" "" "Neddylation; Neutrophil degranulation" "2" "0" "1.002" "0.914" "1.195" "1.153" "1.015" "1.151" "1.101" "1.123" "1.960" "141.1" "141.4" "128.9" "168.6" "162.6" "143.2" "162.3" "155.3" "158.4" "276.4" "" "" "" "" "" "" "" "" "" "" "126.8" "114.4" "116.6" "164.6" "134.2" "143.2" "121.5" "137.2" "141.7" "98.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6046703873344704710" "False" "High" "IsMasterProtein" "Q9H1D9" "DNA-directed RNA polymerase III subunit RPC6 OS=Homo sapiens OX=9606 GN=POLR3F PE=1 SV=1" "0.000" "False" "19.467" "21" "4" "5" "4" "316" "35.7" "6.11" "21.55" "4" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05158" "10621" "ENSG00000132664" "POLR3F" "A8K4C7; hsa:10621; O15319; Q9H1D9" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.052" "1.248" "1.181" "1.251" "0.973" "1.187" "1.139" "1.089" "1.161" "161.6" "169.9" "201.5" "190.8" "202.1" "157.1" "191.8" "184.0" "175.9" "187.5" "" "" "" "" "" "" "" "" "" "" "145.3" "137.5" "182.3" "186.3" "166.7" "157.1" "143.6" "162.6" "157.4" "66.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4399142244827454415" "False" "High" "IsMasterProtein" "Q8NFD5" "AT-rich interactive domain-containing protein 1B OS=Homo sapiens OX=9606 GN=ARID1B PE=1 SV=3" "0.000" "False" "19.465" "3" "5" "8" "4" "2319" "243.8" "6.90" "25.03" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf12031" "57492" "ENSG00000049618" "ARID1B" "hsa:57492; Q5JRD1; Q5VYC4; Q8IZY8; Q8NFD5; Q8TEV0; Q8TF02; Q99491; Q9ULI5" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.958" "0.934" "0.964" "0.991" "0.933" "1.065" "0.905" "0.738" "2.336" "418.3" "400.7" "390.6" "403.3" "414.4" "390.1" "445.3" "378.4" "308.5" "977.3" "" "" "" "" "" "" "" "" "" "" "376.1" "324.2" "353.3" "393.7" "342.0" "390.1" "333.4" "334.2" "276.1" "348.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5558995711693310036" "False" "High" "IsMasterProtein" "Q9BWW4" "Single-stranded DNA-binding protein 3 OS=Homo sapiens OX=9606 GN=SSBP3 PE=1 SV=1" "0.000" "False" "19.456" "10" "3" "6" "2" "388" "40.4" "6.90" "22.77" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04503" "23648" "ENSG00000157216" "SSBP3" "A8K0A9; hsa:23648; Q5T860; Q5T861; Q9BTM0; Q9BWW3; Q9BWW4" "" "" "0" "0" "1.132" "0.972" "1.126" "1.062" "0.971" "1.210" "1.110" "1.074" "0.961" "100.2" "113.4" "97.3" "112.8" "106.4" "97.2" "121.2" "111.1" "107.6" "96.2" "" "" "" "" "" "" "" "" "" "" "90.0" "91.8" "88.0" "110.1" "87.8" "97.2" "90.7" "98.2" "96.3" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1584990058854155939" "False" "High" "IsMasterProtein" "Q9NPI6" "mRNA-decapping enzyme 1A OS=Homo sapiens OX=9606 GN=DCP1A PE=1 SV=3" "0.000" "False" "19.452" "11" "4" "5" "4" "582" "63.2" "6.25" "24.39" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "55802" "ENSG00000272886" "DCP1A" "B4DHN9; hsa:55802; Q9NPI6; U3KQM8" "TGF-beta signaling pathway" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA decay by 5' to 3' exoribonuclease; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "5" "0" "1.033" "1.074" "1.069" "1.172" "1.038" "1.159" "1.084" "1.170" "1.854" "326.5" "337.3" "350.7" "349.0" "382.7" "339.0" "378.3" "354.1" "381.9" "605.4" "" "" "" "" "" "" "" "" "" "" "293.6" "272.9" "317.2" "340.7" "315.8" "339.0" "283.3" "312.7" "341.8" "216.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8966374980505742475" "False" "High" "IsMasterProtein" "Q15047" "Histone-lysine N-methyltransferase SETDB1 OS=Homo sapiens OX=9606 GN=SETDB1 PE=1 SV=1" "0.000" "False" "19.431" "5" "7" "9" "7" "1291" "143.1" "6.02" "26.39" "7" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01429, Pf05033, Pf18300, Pf18358, Pf18359" "9869" "ENSG00000143379" "SETDB1" "A6NEW2; hsa:9869; Q15047; Q5SZD8; Q5SZD9; Q5SZE0; Q5SZE7; Q96GM9" "Histone modifications; Pleural mesothelioma" "PKMTs methylate histone lysines" "3" "0" "0.932" "0.960" "1.052" "1.183" "1.020" "0.992" "0.860" "1.113" "1.857" "51.7" "48.1" "49.6" "54.4" "61.1" "52.7" "51.2" "44.4" "57.5" "95.9" "" "" "" "" "" "" "" "" "" "" "46.4" "38.9" "44.8" "53.1" "50.4" "52.7" "38.4" "39.2" "51.5" "34.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5013600273074776242" "False" "High" "IsMasterProtein" "Q9NZ09" "Ubiquitin-associated protein 1 OS=Homo sapiens OX=9606 GN=UBAP1 PE=1 SV=1" "0.000" "False" "19.401" "12" "4" "5" "4" "502" "55.0" "5.11" "21.27" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21267" "51271" "ENSG00000165006" "UBAP1" "B7Z348; B7Z8N9; D3DRL7; F5GXE2; F5H0J8; hsa:51271; Q4V759; Q53FP7; Q5T7B3; Q6FI75; Q8NC52; Q8NCG6; Q8NCH9; Q9NZ09" "" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "5" "0" "1.048" "0.987" "0.905" "1.094" "1.070" "1.035" "1.002" "1.092" "1.197" "316.2" "331.4" "312.1" "286.1" "345.8" "338.4" "327.2" "316.9" "345.2" "378.6" "" "" "" "" "" "" "" "" "" "" "284.3" "268.2" "282.3" "279.2" "285.4" "338.4" "245.0" "279.9" "308.9" "135.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-823041984393634953" "False" "High" "IsMasterProtein" "P25774" "Cathepsin S OS=Homo sapiens OX=9606 GN=CTSS PE=1 SV=3" "0.000" "False" "19.373" "20" "6" "8" "6" "331" "37.5" "8.34" "23.59" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1520" "ENSG00000163131" "CTSS" "B4DWC9; D3DV05; hsa:1520; P25774; Q5T5I0; Q6FHS5; Q9BUG3" "" "Neutrophil degranulation; MHC class II antigen presentation; Degradation of the extracellular matrix; Assembly of collagen fibrils and other multimeric structures; Trafficking and processing of endosomal TLR; Endosomal/Vacuolar pathway" "6" "0" "0.995" "1.058" "1.095" "1.061" "0.950" "1.079" "1.015" "1.042" "0.888" "681.3" "678.1" "720.7" "746.3" "723.1" "647.5" "735.4" "691.2" "709.6" "604.9" "" "" "" "" "" "" "" "" "" "" "612.5" "548.7" "651.9" "728.5" "596.7" "647.5" "550.6" "610.5" "635.0" "215.9" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5277181117143708744" "False" "High" "IsMasterProtein" "P60866" "Small ribosomal subunit protein uS10 OS=Homo sapiens OX=9606 GN=RPS20 PE=1 SV=1" "0.000" "False" "19.373" "33" "5" "14" "5" "119" "13.4" "9.94" "45.48" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00338" "6224" "ENSG00000008988" "RPS20" "B2R4F4; B4DW28; hsa:6224; P17075; P60866; Q5M8S9" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "1.051" "1.026" "0.960" "1.067" "1.114" "0.998" "1.080" "1.017" "1.018" "1150.3" "1209.5" "1180.1" "1104.0" "1227.1" "1281.2" "1148.1" "1242.3" "1170.3" "1170.8" "" "" "" "" "" "" "" "" "" "" "1034.2" "978.7" "1067.4" "1077.7" "1012.6" "1281.2" "859.7" "1097.3" "1047.2" "418.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3864201792584752389" "False" "High" "IsMasterProtein" "Q03188" "Centromere protein C OS=Homo sapiens OX=9606 GN=CENPC PE=1 SV=2" "0.000" "False" "19.370" "7" "6" "7" "6" "943" "106.8" "9.39" "21.12" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11699, Pf15620, Pf15622" "1060" "ENSG00000145241" "CENPC" "hsa:1060; Q03188; Q6PIR0; Q8IW27; Q9P0M5" "" "Separation of Sister Chromatids; Deposition of new CENPA-containing nucleosomes at the centromere; RHO GTPases Activate Formins; Resolution of Sister Chromatid Cohesion; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.027" "0.991" "0.941" "1.114" "1.088" "1.034" "0.986" "1.019" "1.020" "347.6" "357.1" "344.5" "327.0" "387.1" "378.1" "359.3" "342.8" "354.1" "354.6" "" "" "" "" "" "" "" "" "" "" "312.5" "288.9" "311.6" "319.2" "319.4" "378.1" "269.0" "302.8" "316.9" "126.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5593036104782441701" "False" "High" "IsMasterProtein" "Q8NCF5" "NFATC2-interacting protein OS=Homo sapiens OX=9606 GN=NFATC2IP PE=1 SV=1" "0.000" "False" "19.351" "15" "4" "8" "4" "419" "45.8" "6.60" "30.61" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf11976" "84901" "ENSG00000176953" "NFATC2IP" "B7Z4G5; hsa:84901; Q66K34; Q6NVK1; Q8NCF5; Q8NFR2; Q96ST9" "16p11.2 distal deletion syndrome" "" "1" "0" "0.941" "1.026" "1.023" "0.979" "0.987" "0.959" "0.981" "1.021" "0.961" "690.7" "649.6" "708.7" "706.2" "675.9" "682.0" "662.1" "677.8" "705.2" "663.5" "" "" "" "" "" "" "" "" "" "" "621.0" "525.6" "641.1" "689.4" "557.7" "682.0" "495.8" "598.6" "631.0" "236.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043086942307680796" "False" "High" "IsMasterProtein" "P63220" "Small ribosomal subunit protein eS21 OS=Homo sapiens OX=9606 GN=RPS21 PE=1 SV=1" "0.000" "False" "19.350" "53" "5" "16" "5" "83" "9.1" "8.50" "58.18" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01249" "6227" "ENSG00000171858" "RPS21" "hsa:6227; P35265; P63220" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "0.931" "1.011" "0.902" "0.990" "1.038" "0.925" "1.015" "0.978" "0.742" "796.7" "741.7" "805.3" "718.9" "788.4" "826.8" "737.3" "808.7" "779.5" "591.3" "" "" "" "" "" "" "" "" "" "" "716.3" "600.2" "728.4" "701.8" "650.6" "826.8" "552.1" "714.3" "697.5" "211.1" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1395564513229487982" "False" "High" "IsMasterProtein" "O94826" "Mitochondrial import receptor subunit TOM70 OS=Homo sapiens OX=9606 GN=TOMM70 PE=1 SV=1" "0.000" "False" "19.349" "10" "7" "7" "7" "608" "67.4" "7.12" "23.86" "7" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00515, Pf13181" "9868" "ENSG00000154174" "TOMM70" "D3DN48; hsa:9868; O94826" "Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction" "Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Mitochondrial protein import; DDX58/IFIH1-mediated induction of interferon-alpha/beta; SARS-CoV-1 activates/modulates innate immune responses; PINK1-PRKN Mediated Mitophagy" "9" "0" "0.964" "0.965" "1.018" "0.889" "0.933" "0.991" "0.979" "0.960" "0.974" "598.7" "577.1" "577.5" "609.3" "532.5" "558.7" "593.1" "586.0" "574.7" "583.3" "" "" "" "" "" "" "" "" "" "" "538.3" "467.0" "522.4" "594.8" "439.4" "558.7" "444.1" "517.6" "514.2" "208.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6145524999594346517" "False" "High" "IsMasterProtein" "O60518" "Ran-binding protein 6 OS=Homo sapiens OX=9606 GN=RANBP6 PE=1 SV=2" "0.000" "False" "19.346" "5" "5" "8" "2" "1105" "124.6" "5.01" "27.76" "5" "transport" "nucleus;other cell component" "other molecular function" "Pf02985, Pf13513, Pf18808, Pf18829" "26953" "ENSG00000137040" "RANBP6" "hsa:26953; O60518; Q5T7X4; Q7Z3V2; Q96E78" "" "" "0" "0" "0.972" "0.939" "0.874" "1.008" "0.880" "1.006" "1.008" "0.920" "1.152" "267.0" "259.6" "250.8" "233.3" "269.2" "234.9" "268.5" "269.0" "245.7" "307.7" "" "" "" "" "" "" "" "" "" "" "240.1" "210.0" "226.8" "227.8" "222.2" "234.9" "201.0" "237.6" "219.8" "109.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2811678325838740313" "False" "High" "IsMasterProtein" "Q9NXW9" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Homo sapiens OX=9606 GN=ALKBH4 PE=1 SV=1" "0.000" "False" "19.344" "17" "4" "8" "4" "302" "33.8" "6.67" "29.92" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "54784" "ENSG00000160993" "ALKBH4" "hsa:54784; Q53H92; Q9H6A4; Q9NXW9" "" "" "0" "0" "1.023" "0.966" "0.976" "1.105" "1.009" "1.049" "1.127" "0.938" "1.259" "187.6" "192.0" "181.2" "183.1" "207.4" "189.3" "196.7" "211.5" "175.9" "236.1" "" "" "" "" "" "" "" "" "" "" "168.7" "155.3" "163.9" "178.8" "171.1" "189.3" "147.3" "186.8" "157.4" "84.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3418944464620685589" "False" "High" "IsMasterProtein" "Q9Y478" "5'-AMP-activated protein kinase subunit beta-1 OS=Homo sapiens OX=9606 GN=PRKAB1 PE=1 SV=4" "0.000" "False" "19.336" "27" "4" "5" "4" "270" "30.4" "6.40" "24.33" "4" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf04739, Pf16561" "5564" "ENSG00000111725" "PRKAB1" "hsa:5564; Q9UBV0; Q9UE20; Q9UEX2; Q9Y478; Q9Y6V8" "AMP-activated protein kinase signaling; Target of rapamycin signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Angiopoietin-like protein 8 regulatory pathway; Leptin and adiponectin; Lipid metabolism pathway; Hereditary leiomyomatosis and renal cell carcinoma pathway; Thermogenesis; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; 1q21.1 copy number variation syndrome; Autophagy; p53 transcriptional gene network; Pleural mesothelioma" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Regulation of TP53 Activity through Phosphorylation; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Activation of AMPK downstream of NMDARs; Activation of PPARGC1A (PGC-1alpha) by phosphorylation; Lipophagy" "25" "0" "0.999" "1.018" "0.979" "1.020" "0.980" "0.973" "1.089" "1.018" "0.904" "353.7" "353.5" "360.2" "346.3" "360.9" "346.5" "344.1" "385.2" "360.0" "319.9" "" "" "" "" "" "" "" "" "" "" "318.0" "286.0" "325.8" "338.1" "297.8" "346.5" "257.6" "340.2" "322.1" "114.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2659505507426523226" "False" "High" "IsMasterProtein" "P0CAP2" "DNA-directed RNA polymerase II subunit GRINL1A OS=Homo sapiens OX=9606 GN=POLR2M PE=1 SV=1" "0.000" "False" "19.335" "17" "5" "5" "5" "368" "41.7" "6.39" "17.83" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15328" "81488" "ENSG00000255529" "POLR2M" "hsa:81488; P0CAP2; Q6EER8; Q6EES2; Q6EEV3; Q6EF00; Q6EF01; Q6EF02; Q6EF46; Q6EFN8; Q6EM48; Q6K046; Q6K050; Q6K051; Q6ZQZ3; Q8NC58; Q8NCF3; Q96DI5; Q96JB7; Q96NF5; Q9Y3V6" "" "" "0" "0" "0.864" "0.931" "0.862" "0.993" "0.938" "0.911" "0.891" "0.970" "0.936" "336.6" "290.6" "313.5" "290.2" "334.3" "315.6" "306.5" "300.0" "326.5" "315.0" "" "" "" "" "" "" "" "" "" "" "302.6" "235.2" "283.6" "283.3" "275.9" "315.6" "229.5" "265.0" "292.2" "112.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7438164124212550785" "False" "High" "IsMasterProtein" "Q96EV8" "Dysbindin OS=Homo sapiens OX=9606 GN=DTNBP1 PE=1 SV=1" "0.000" "False" "19.333" "17" "5" "7" "5" "351" "39.5" "4.67" "19.45" "5" "cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04440" "84062" "ENSG00000047579" "DTNBP1" "A8K3V3; hsa:84062; Q5THY3; Q5THY4; Q96EV8; Q96NV2; Q9H0U2; Q9H3J5" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.986" "0.914" "1.065" "0.988" "1.078" "1.068" "0.947" "1.133" "1.132" "225.6" "222.4" "206.2" "240.3" "223.0" "243.2" "241.0" "213.6" "255.7" "255.5" "" "" "" "" "" "" "" "" "" "" "202.9" "179.9" "186.5" "234.6" "184.0" "243.2" "180.4" "188.7" "228.8" "91.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8377264718886898276" "False" "High" "IsMasterProtein" "Q9Y2K7" "Lysine-specific demethylase 2A OS=Homo sapiens OX=9606 GN=KDM2A PE=1 SV=3" "0.000" "False" "19.327" "6" "7" "8" "7" "1162" "132.7" "7.58" "24.84" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00646, Pf02008, Pf16866, Pf17811" "22992" "ENSG00000173120" "KDM2A" "D4QA03; E9PIL6; hsa:22992; I3VM55; Q49A21; Q4G0M3; Q69YY8; Q9BVH5; Q9H7H5; Q9UK66; Q9Y2K7" "" "HDMs demethylate histones" "1" "0" "0.966" "1.032" "0.860" "1.080" "1.091" "1.068" "0.940" "0.853" "0.767" "113.4" "109.5" "117.1" "97.5" "122.5" "123.7" "121.1" "106.6" "96.8" "87.0" "" "" "" "" "" "" "" "" "" "" "102.0" "88.6" "105.9" "95.2" "101.1" "123.7" "90.7" "94.2" "86.6" "31.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1314787517679089989" "False" "High" "IsMasterProtein" "Q8WUX9" "Charged multivesicular body protein 7 OS=Homo sapiens OX=9606 GN=CHMP7 PE=1 SV=1" "0.000" "False" "19.317" "9" "5" "6" "5" "453" "50.9" "5.35" "21.10" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "91782" "ENSG00000147457" "CHMP7" "B2RDT3; B4DKJ6; D3DSS1; hsa:91782; Q8NDM1; Q8WUX9; Q9BT50" "" "Late endosomal microautophagy; Macroautophagy; Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Sealing of the nuclear envelope (NE) by ESCRT-III; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "1.062" "1.038" "1.007" "1.026" "1.053" "1.081" "0.962" "0.998" "2.873" "431.7" "458.3" "448.2" "434.6" "443.1" "454.7" "466.6" "415.3" "430.9" "1240.6" "" "" "" "" "" "" "" "" "" "" "388.2" "370.9" "405.4" "424.3" "365.6" "454.7" "349.4" "366.8" "385.5" "442.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-909250529717419183" "False" "High" "IsMasterProtein" "P26447" "Protein S100-A4 OS=Homo sapiens OX=9606 GN=S100A4 PE=1 SV=1" "0.000" "False" "19.307" "29" "3" "9" "3" "101" "11.7" "6.11" "30.77" "3" "signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf01023" "6275" "ENSG00000196154" "S100A4" "A8K7R8; D3DV46; hsa:6275; P26447; Q6ICP8" "Vitamin D receptor pathway" "" "1" "0" "0.972" "0.934" "0.967" "1.019" "1.031" "1.071" "0.972" "1.043" "0.962" "814.9" "791.8" "760.8" "787.6" "830.1" "839.8" "872.7" "791.6" "850.2" "784.2" "" "" "" "" "" "" "" "" "" "" "732.6" "640.7" "688.2" "768.8" "685.0" "839.8" "653.4" "699.2" "760.7" "279.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2508229497243424265" "False" "High" "IsMasterProtein" "P82673" "Small ribosomal subunit protein mS35 OS=Homo sapiens OX=9606 GN=MRPS35 PE=1 SV=1" "0.000" "False" "19.296" "24" "7" "8" "7" "323" "36.8" "8.24" "22.25" "7" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10213" "60488" "ENSG00000061794" "MRPS35" "hsa:60488; P82673; Q32LZ1; Q6P4C6; Q7L1M6; Q8NBP4; Q96AI0; Q9H044; Q9HC14; Q9P1R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.806" "0.870" "0.909" "0.830" "0.804" "0.897" "0.849" "0.829" "1.445" "719.0" "579.5" "625.7" "653.3" "596.8" "578.4" "644.9" "610.2" "595.8" "1038.7" "" "" "" "" "" "" "" "" "" "" "646.4" "468.9" "565.9" "637.7" "492.5" "578.4" "482.9" "538.9" "533.1" "370.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1241863298076822509" "False" "High" "IsMasterProtein" "Q5VUA4" "Zinc finger protein 318 OS=Homo sapiens OX=9606 GN=ZNF318 PE=1 SV=2" "0.000" "False" "19.290" "3" "7" "8" "7" "2279" "251.0" "7.20" "20.66" "7" "cell cycle OR cell proliferation;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "24149" "ENSG00000171467" "ZNF318" "hsa:24149; O94796; Q4G0E4; Q5VUA4; Q8NEM6; Q9UNU8; Q9Y2W9" "Androgen receptor signaling pathway" "" "1" "0" "1.033" "1.014" "1.056" "1.084" "1.023" "1.082" "0.988" "1.001" "1.102" "546.4" "564.4" "554.3" "577.1" "592.4" "559.1" "591.5" "539.8" "547.0" "602.4" "" "" "" "" "" "" "" "" "" "" "491.3" "456.7" "501.4" "563.3" "488.9" "559.1" "442.9" "476.8" "489.5" "215.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7526425454586707099" "False" "High" "IsMasterProtein" "Q8TE02" "Elongator complex protein 5 OS=Homo sapiens OX=9606 GN=ELP5 PE=1 SV=3" "0.000" "False" "19.285" "19" "5" "7" "5" "300" "33.2" "4.98" "23.62" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10483" "23587" "ENSG00000170291; ENSG00000288485" "ELP5" "A8K1M5; D3DTN9; Q659B6; Q7Z2T4; Q8TDR9; Q8TE02; Q9BUB2; Q9Y2Q4" "" "HATs acetylate histones" "1" "0" "1.009" "1.136" "0.922" "1.003" "0.951" "0.945" "0.950" "0.956" "0.901" "631.0" "636.7" "716.9" "581.8" "632.8" "599.9" "596.1" "599.3" "603.2" "568.5" "" "" "" "" "" "" "" "" "" "" "567.3" "515.2" "648.5" "567.9" "522.2" "599.9" "446.3" "529.3" "539.7" "202.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776455647046576995" "False" "High" "IsMasterProtein" "Q7L3B6" "Hsp90 co-chaperone Cdc37-like 1 OS=Homo sapiens OX=9606 GN=CDC37L1 PE=1 SV=1" "0.000" "False" "19.248" "16" "5" "8" "5" "337" "38.8" "5.34" "26.06" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf08565" "55664" "ENSG00000106993" "CDC37L1" "B1AL70; hsa:55664; Q7L3B6; Q9NWS3; Q9NX16" "" "Platelet degranulation" "1" "0" "0.997" "1.076" "0.971" "1.072" "1.123" "1.055" "1.017" "1.069" "0.885" "711.2" "709.2" "765.2" "691.0" "762.3" "798.8" "750.1" "723.3" "760.0" "629.7" "" "" "" "" "" "" "" "" "" "" "639.5" "573.9" "692.1" "674.5" "629.1" "798.8" "561.7" "638.9" "680.1" "224.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7931435872977733703" "False" "High" "IsMasterProtein" "P05556" "Integrin beta-1 OS=Homo sapiens OX=9606 GN=ITGB1 PE=1 SV=2" "0.000" "False" "19.225" "6" "5" "5" "5" "798" "88.4" "5.39" "17.24" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00362, Pf07965, Pf07974, Pf08725, Pf17205, Pf18372" "3688" "ENSG00000150093" "ITGB1" "A8K6N2; D3DRX9; D3DRY3; D3DRY4; D3DRY5; hsa:3688; P05556; P78466; P78467; Q13089; Q13090; Q13091; Q13212; Q14622; Q14647; Q29RW2; Q7Z3V1; Q8WUM6" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Neural crest differentiation; Arrhythmogenic right ventricular cardiomyopathy; Pathogenic Escherichia coli infection; Primary focal segmental glomerulosclerosis (FSGS); Mammary gland development pathway - Embryonic development (Stage 1 of 4); Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Small cell lung cancer; Gastrin signaling pathway; Genes controlling nephrogenesis; Development of ureteric collection system; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; 11p11.2 copy number variation syndrome ; Macrophage-stimulating protein (MSP) signaling network map; TAR syndrome; Cell lineage map for neuronal differentiation" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; RAC1 GTPase cycle; RHOG GTPase cycle; RHO GTPases Activate Formins; HCMV Early Events; RAC2 GTPase cycle; RAC3 GTPase cycle; Integrin cell surface interactions; ECM proteoglycans; GPER1 signaling; CHL1 interactions; Interleukin-4 and Interleukin-13 signaling; Signal transduction by L1; Syndecan interactions; Other semaphorin interactions; Laminin interactions; MET activates PTK2 signaling; Basigin interactions; Formation of the ureteric bud; Platelet Adhesion to exposed collagen; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs; Fibronectin matrix formation; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; MET interacts with TNS proteins" "58" "0" "0.875" "0.914" "0.972" "0.980" "0.953" "0.869" "0.906" "0.952" "0.833" "228.0" "199.4" "208.2" "221.6" "223.5" "217.2" "198.1" "206.5" "217.0" "189.9" "" "" "" "" "" "" "" "" "" "" "205.0" "161.4" "188.4" "216.3" "184.4" "217.2" "148.3" "182.4" "194.1" "67.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "997292728151378108" "False" "High" "IsMasterProtein" "P32519" "ETS-related transcription factor Elf-1 OS=Homo sapiens OX=9606 GN=ELF1 PE=1 SV=2" "0.000" "False" "19.166" "11" "6" "7" "6" "619" "67.5" "5.21" "25.19" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf12310" "1997" "ENSG00000120690" "ELF1" "B4E2I5; E9PDQ9; hsa:1997; P32519; Q8N6F6; Q9UDE1" "" "RUNX1 regulates transcription of genes involved in interleukin signaling; RUNX1 regulates transcription of genes involved in BCR signaling" "2" "0" "1.105" "0.924" "1.041" "1.059" "0.963" "1.188" "0.969" "0.958" "5.068" "292.5" "323.3" "270.3" "304.4" "309.6" "281.6" "347.4" "283.5" "280.3" "1482.5" "" "" "" "" "" "" "" "" "" "" "263.0" "261.6" "244.5" "297.2" "255.5" "281.6" "260.1" "250.4" "250.8" "529.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4732323992224053242" "False" "High" "IsMasterProtein" "Q9NU22" "Midasin OS=Homo sapiens OX=9606 GN=MDN1 PE=1 SV=2" "0.000" "False" "19.166" "1" "6" "6" "5" "5596" "632.4" "5.68" "20.45" "6" "cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07728, Pf17865, Pf17867, Pf21108" "23195" "ENSG00000112159" "MDN1" "hsa:23195; O15019; Q5T794; Q9NU22" "" "" "0" "0" "0.974" "1.038" "0.998" "0.868" "0.935" "1.020" "0.925" "0.981" "1.656" "150.3" "146.3" "155.9" "150.0" "130.4" "140.5" "153.3" "139.0" "147.4" "248.8" "" "" "" "" "" "" "" "" "" "" "135.1" "118.4" "141.1" "146.4" "107.6" "140.5" "114.8" "122.8" "131.9" "88.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1610110799858015964" "False" "High" "IsMasterProtein" "P20674" "Cytochrome c oxidase subunit 5A, mitochondrial OS=Homo sapiens OX=9606 GN=COX5A PE=1 SV=2" "0.000" "False" "19.123" "21" "3" "8" "3" "150" "16.8" "6.79" "28.55" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02284" "9377" "ENSG00000178741" "COX5A" "hsa:9377; P20674; P30045; Q8TB65" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation; Arachidonate epoxygenase / epoxide hydrolase" "Respiratory electron transport; Mitochondrial protein degradation; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "9" "0" "0.887" "0.952" "0.916" "0.965" "0.944" "0.928" "1.026" "0.958" "0.775" "799.5" "709.0" "760.9" "732.7" "771.3" "754.4" "742.2" "820.4" "765.8" "620.0" "" "" "" "" "" "" "" "" "" "" "718.9" "573.7" "688.2" "715.2" "636.5" "754.4" "555.8" "724.6" "685.3" "221.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8250154090209623680" "False" "High" "IsMasterProtein" "Q9H2W6" "Large ribosomal subunit protein mL46 OS=Homo sapiens OX=9606 GN=MRPL46 PE=1 SV=1" "0.000" "False" "19.115" "16" "5" "8" "5" "279" "31.7" "7.05" "25.34" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf11788" "26589" "ENSG00000259494" "MRPL46" "B2RD75; hsa:26589; Q9H2W6; Q9HBU8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.061" "1.070" "0.977" "1.108" "1.067" "1.126" "1.060" "1.070" "1.090" "871.2" "924.6" "932.2" "851.0" "965.7" "929.3" "981.1" "923.6" "932.3" "949.9" "" "" "" "" "" "" "" "" "" "" "783.3" "748.1" "843.2" "830.7" "796.9" "929.3" "734.6" "815.8" "834.2" "339.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5201932136610495476" "False" "High" "IsMasterProtein" "Q8NHL6" "Leukocyte immunoglobulin-like receptor subfamily B member 1 OS=Homo sapiens OX=9606 GN=LILRB1 PE=1 SV=1" "0.000" "False" "19.088" "11" "5" "8" "5" "650" "70.8" "6.05" "14.41" "5" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00047, Pf13895" "10859" "ENSG00000274669; ENSG00000277807" "LILRB1" "A2IXV4; A8MXT0; hsa:10859; O75024; O75025; Q8NHJ9; Q8NHK0; Q8NHL6" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell" "1" "0" "0.932" "0.909" "1.011" "1.135" "1.108" "1.154" "0.942" "0.905" "0.892" "114.7" "106.9" "104.3" "116.0" "130.2" "127.2" "132.5" "108.1" "103.8" "102.4" "" "" "" "" "" "" "" "" "" "" "103.2" "86.5" "94.3" "113.2" "107.4" "127.2" "99.2" "95.5" "92.9" "36.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8809739148280005605" "False" "High" "IsMasterProtein" "P46776" "Large ribosomal subunit protein uL15 OS=Homo sapiens OX=9606 GN=RPL27A PE=1 SV=2" "0.000" "False" "19.085" "34" "5" "6" "5" "148" "16.6" "11.00" "21.73" "5" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00828" "6157" "ENSG00000166441" "RPL27A" "B2R4B3; hsa:6157; P46776" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Protein hydroxylation; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.967" "0.998" "0.884" "0.934" "0.942" "0.938" "0.939" "0.950" "1.096" "549.4" "531.0" "548.4" "485.9" "513.0" "517.4" "515.3" "515.7" "522.0" "601.9" "" "" "" "" "" "" "" "" "" "" "494.0" "429.7" "496.0" "474.3" "423.4" "517.4" "385.8" "455.5" "467.0" "214.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5995744781224398015" "False" "High" "IsMasterProtein" "P10746" "Uroporphyrinogen-III synthase OS=Homo sapiens OX=9606 GN=UROS PE=1 SV=1" "0.000" "False" "19.080" "25" "6" "7" "6" "265" "28.6" "5.48" "20.51" "6" "other metabolic processes;other biological processes" "cytosol;mitochondrion" "other molecular function" "Pf02602" "7390" "ENSG00000188690" "UROS" "B2RC13; D3DRF7; hsa:7390; P10746; Q9H2T1" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "3" "0" "0.925" "1.153" "1.009" "1.090" "0.969" "1.063" "1.063" "1.026" "1.070" "173.1" "160.1" "199.6" "174.7" "188.7" "167.8" "184.1" "184.0" "177.7" "185.3" "" "" "" "" "" "" "" "" "" "" "155.7" "129.6" "180.5" "170.6" "155.7" "167.8" "137.8" "162.5" "159.0" "66.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7858959922113811047" "False" "High" "IsMasterProtein" "Q6ZMI0" "Protein phosphatase 1 regulatory subunit 21 OS=Homo sapiens OX=9606 GN=PPP1R21 PE=1 SV=1" "0.000" "False" "19.069" "8" "6" "6" "6" "780" "88.3" "6.84" "19.20" "6" "" "other cytoplasmic organelle" "" "Pf10205, Pf10212, Pf21636" "129285" "ENSG00000162869" "PPP1R21" "B7ZKY5; B7ZKY7; E1B6W7; hsa:129285; Q2TA78; Q6ZMI0; Q6ZMI6; Q8IW83; Q8J029; Q96ES8" "" "" "0" "0" "1.069" "1.059" "0.971" "1.058" "1.026" "1.022" "1.025" "0.996" "1.172" "171.6" "183.4" "181.6" "166.6" "181.6" "176.0" "175.4" "175.9" "170.9" "201.1" "" "" "" "" "" "" "" "" "" "" "154.3" "148.4" "164.3" "162.6" "149.9" "176.0" "131.3" "155.4" "152.9" "71.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7404612744659791932" "False" "High" "IsMasterProtein" "Q01658" "Protein Dr1 OS=Homo sapiens OX=9606 GN=DR1 PE=1 SV=1" "0.000" "False" "19.020" "20" "4" "10" "4" "176" "19.4" "4.75" "37.17" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "1810" "ENSG00000117505" "DR1" "hsa:1810; Q01658" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "0.881" "0.968" "0.916" "1.017" "0.998" "1.006" "1.004" "1.017" "0.810" "1301.1" "1146.9" "1258.9" "1192.2" "1323.5" "1298.9" "1308.7" "1306.4" "1323.5" "1054.3" "" "" "" "" "" "" "" "" "" "" "1169.9" "928.0" "1138.7" "1163.7" "1092.2" "1298.9" "979.9" "1153.9" "1184.2" "376.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7003059613136436384" "False" "High" "IsMasterProtein" "P11217" "Glycogen phosphorylase, muscle form OS=Homo sapiens OX=9606 GN=PYGM PE=1 SV=6" "0.000" "False" "19.013" "7" "5" "6" "1" "842" "97.0" "7.03" "20.75" "5" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00343" "5837" "ENSG00000068976" "PYGM" "A0AVK1; A6NDY6; hsa:5837; P11217" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "0.910" "1.315" "0.867" "0.943" "0.904" "1.227" "1.151" "0.863" "1.323" "14.8" "13.4" "19.4" "12.8" "13.9" "13.4" "18.1" "17.0" "12.8" "19.5" "" "" "" "" "" "" "" "" "" "" "13.3" "10.9" "17.6" "12.5" "11.5" "13.4" "13.6" "15.0" "11.4" "7.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6810289511595074622" "False" "High" "IsMasterProtein" "Q15758" "Neutral amino acid transporter B(0) OS=Homo sapiens OX=9606 GN=SLC1A5 PE=1 SV=2" "0.000" "False" "19.013" "13" "5" "7" "5" "541" "56.6" "5.48" "22.34" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity;other molecular function" "Pf00375" "6510" "ENSG00000105281" "SLC1A5" "A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01; hsa:6510; O95720; Q15758; Q96RL9; Q9BWQ3; Q9UNP2" "TYROBP causal network in microglia; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Metabolic reprogramming in colon cancer; Ferroptosis; Amino acid metabolism in triple-negative breast cancer cells" "RHOQ GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle; RAC3 GTPase cycle; RHOH GTPase cycle; Amino acid transport across the plasma membrane" "11" "0" "0.917" "0.941" "0.987" "0.983" "0.918" "1.063" "0.971" "1.116" "0.712" "497.9" "456.5" "468.5" "491.6" "489.6" "457.2" "529.5" "483.6" "555.8" "354.7" "" "" "" "" "" "" "" "" "" "" "447.7" "369.4" "423.8" "479.9" "404.0" "457.2" "396.5" "427.1" "497.3" "126.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "364086976847350379" "False" "High" "IsMasterProtein" "Q7L592" "Protein arginine methyltransferase NDUFAF7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFAF7 PE=1 SV=1" "0.000" "False" "19.010" "17" "6" "6" "6" "441" "49.2" "8.34" "26.63" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf02636" "55471" "ENSG00000003509" "NDUFAF7" "hsa:55471; Q7L592; Q7Z399; Q9P1G3" "" "Complex I biogenesis" "1" "0" "1.045" "1.097" "0.944" "1.018" "1.139" "0.961" "0.975" "1.004" "1.705" "492.6" "514.9" "540.5" "465.0" "501.5" "561.0" "473.3" "480.2" "494.7" "840.1" "" "" "" "" "" "" "" "" "" "" "442.9" "416.7" "488.9" "453.9" "413.8" "561.0" "354.4" "424.2" "442.7" "299.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "710012249327667382" "False" "High" "IsMasterProtein" "P48449" "Lanosterol synthase OS=Homo sapiens OX=9606 GN=LSS PE=1 SV=1" "0.000" "False" "19.006" "9" "7" "9" "7" "732" "83.3" "6.61" "27.44" "7" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00432" "4047" "ENSG00000160285" "LSS" "B4DJZ9; D3DSN0; E9PEI9; G5E9Q9; P48449; Q8IYL6; Q9UEZ1" "Cholesterol biosynthesis pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "8" "0" "0.933" "1.034" "0.962" "0.951" "0.972" "0.947" "0.849" "0.992" "0.863" "366.0" "341.4" "378.6" "352.2" "348.0" "355.9" "346.6" "310.6" "363.1" "315.9" "" "" "" "" "" "" "" "" "" "" "329.1" "276.2" "342.4" "343.8" "287.2" "355.9" "259.5" "274.3" "324.9" "112.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4405181458594490981" "False" "High" "IsMasterProtein" "Q9NYL2" "Mitogen-activated protein kinase kinase kinase 20 OS=Homo sapiens OX=9606 GN=MAP3K20 PE=1 SV=3" "0.000" "False" "18.970" "8" "5" "5" "5" "800" "91.1" "7.87" "20.54" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00536, Pf07714" "51776" "ENSG00000091436" "MAP3K20" "B3KPG2; hsa:51776; Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; Q9NYL2" "MAPK signaling pathway" "" "1" "0" "0.980" "0.992" "0.885" "1.044" "0.972" "0.988" "0.957" "1.061" "0.770" "408.4" "400.4" "405.1" "361.5" "426.3" "396.9" "403.6" "391.1" "433.4" "314.5" "" "" "" "" "" "" "" "" "" "" "367.2" "324.0" "366.4" "352.8" "351.8" "396.9" "302.2" "345.4" "387.8" "112.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2974291959383986730" "False" "High" "IsMasterProtein" "Q9UL33" "Trafficking protein particle complex subunit 2-like protein OS=Homo sapiens OX=9606 GN=TRAPPC2L PE=1 SV=1" "0.000" "False" "18.952" "33" "5" "8" "5" "140" "16.1" "6.77" "29.45" "5" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04628" "51693" "ENSG00000167515" "TRAPPC2L" "B2R4M9; hsa:51693; Q6ZTA7; Q9NZZ4; Q9UL33" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.996" "1.120" "1.022" "1.012" "1.043" "1.017" "0.991" "1.050" "1.015" "1038.8" "1034.2" "1164.0" "1061.7" "1051.2" "1083.3" "1056.2" "1029.8" "1090.6" "1054.4" "" "" "" "" "" "" "" "" "" "" "934.0" "836.9" "1052.8" "1036.4" "867.5" "1083.3" "790.9" "909.6" "975.9" "376.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2858962051142088186" "False" "High" "IsMasterProtein" "Q8WXE1" "ATR-interacting protein OS=Homo sapiens OX=9606 GN=ATRIP PE=1 SV=1" "0.000" "False" "18.916" "7" "5" "6" "5" "791" "85.8" "6.32" "22.82" "5" "DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "" "84126" "ENSG00000164053" "ATRIP" "A8K6A3; A8K714; B2RCE7; B4DU92; B5MEB7; hsa:84126; Q69YK9; Q8NHQ2; Q8WUG7; Q8WXE1; Q96CL3; Q9HA30" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Fanconi Anemia Pathway; Activation of ATR in response to replication stress; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "11" "0" "1.844" "1.010" "0.867" "0.877" "0.795" "0.829" "0.926" "0.957" "0.904" "250.3" "461.6" "252.9" "216.9" "219.5" "199.0" "207.5" "231.8" "239.7" "226.4" "" "" "" "" "" "" "" "" "" "" "225.1" "373.5" "228.7" "211.8" "181.1" "199.0" "155.3" "204.7" "214.5" "80.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7172726289989085897" "False" "High" "IsMasterProtein" "Q8IYB5" "Stromal membrane-associated protein 1 OS=Homo sapiens OX=9606 GN=SMAP1 PE=1 SV=2" "0.000" "False" "18.890" "12" "4" "6" "3" "467" "50.4" "8.75" "26.80" "4" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf01412" "60682" "ENSG00000112305" "SMAP1" "hsa:60682; Q53H70; Q5SYQ2; Q6PK24; Q8IYB5; Q8NDH4; Q96L38; Q96L39; Q9H8X4" "" "" "0" "0" "1.072" "0.993" "0.834" "1.121" "1.125" "1.087" "0.986" "0.838" "0.865" "192.4" "206.2" "191.1" "160.6" "215.6" "216.5" "209.1" "189.6" "161.3" "166.5" "" "" "" "" "" "" "" "" "" "" "173.0" "166.9" "172.8" "156.7" "177.9" "216.5" "156.5" "167.5" "144.3" "59.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5469574299663466694" "False" "High" "IsMasterProtein" "P11233" "Ras-related protein Ral-A OS=Homo sapiens OX=9606 GN=RALA PE=1 SV=1" "0.000" "False" "18.859" "34" "5" "5" "2" "206" "23.6" "7.11" "19.21" "5" "cell cycle OR cell proliferation;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00071" "5898" "ENSG00000006451" "RALA" "A4D1W3; hsa:5898; P11233" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation; p38MAPK events" "8" "0" "0.738" "0.855" "1.051" "0.767" "0.790" "0.817" "0.990" "1.152" "0.762" "50.3" "37.1" "43.0" "52.8" "38.5" "39.7" "41.1" "49.7" "57.9" "38.3" "" "" "" "" "" "" "" "" "" "" "45.2" "30.0" "38.9" "51.5" "31.8" "39.7" "30.7" "43.9" "51.8" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3433213539616798007" "False" "High" "IsMasterProtein" "Q9P2W9" "Syntaxin-18 OS=Homo sapiens OX=9606 GN=STX18 PE=1 SV=1" "0.000" "False" "18.851" "16" "6" "6" "6" "335" "38.7" "5.49" "20.75" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10496" "53407" "ENSG00000168818" "STX18" "hsa:53407; Q596L3; Q5TZP5; Q9P2W9" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "1.136" "1.034" "1.016" "1.040" "0.959" "1.105" "1.054" "0.930" "1.028" "581.2" "660.5" "600.9" "590.3" "604.4" "557.3" "642.1" "612.5" "540.8" "597.5" "" "" "" "" "" "" "" "" "" "" "522.6" "534.5" "543.5" "576.2" "498.8" "557.3" "480.8" "541.0" "483.9" "213.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7530688595643988973" "False" "High" "IsMasterProtein" "Q13510" "Acid ceramidase OS=Homo sapiens OX=9606 GN=ASAH1 PE=1 SV=5" "0.000" "False" "18.844" "11" "5" "6" "5" "395" "44.6" "7.62" "19.00" "5" "other metabolic processes;other biological processes" "non-structural extracellular;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "427" "ENSG00000104763" "ASAH1" "E9PDS0; hsa:427; Q13510; Q6W898; Q96AS2" "Sphingolipid pathway; S1P receptor signal transduction; Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases; Synthesis of ceramides and 1-deoxyceramides" "Neutrophil degranulation; Glycosphingolipid catabolism" "8" "0" "0.991" "1.048" "1.073" "1.121" "1.014" "1.040" "1.066" "1.089" "0.821" "598.3" "592.6" "627.1" "641.7" "670.7" "606.4" "622.2" "637.9" "651.4" "491.1" "" "" "" "" "" "" "" "" "" "" "537.9" "479.5" "567.2" "626.4" "553.4" "606.4" "465.9" "563.4" "582.9" "175.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4971008711368622204" "False" "High" "IsMasterProtein" "Q9BVW5" "TIMELESS-interacting protein OS=Homo sapiens OX=9606 GN=TIPIN PE=1 SV=2" "0.000" "False" "18.843" "15" "5" "7" "5" "301" "34.5" "4.82" "19.84" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07962" "54962" "ENSG00000075131" "TIPIN" "B2CW64; hsa:54962; Q9BVW5; Q9NWZ6" "" "Processing of DNA double-strand break ends" "1" "0" "0.942" "1.169" "0.987" "1.104" "1.217" "1.069" "1.057" "1.189" "1.383" "279.2" "262.8" "326.4" "275.6" "308.3" "339.7" "298.5" "295.1" "331.8" "386.0" "" "" "" "" "" "" "" "" "" "" "251.0" "212.7" "295.2" "269.0" "254.4" "339.7" "223.5" "260.7" "296.9" "137.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7197122219504261731" "False" "High" "IsMasterProtein" "Q96EK9" "Protein KTI12 homolog OS=Homo sapiens OX=9606 GN=KTI12 PE=1 SV=1" "0.000" "False" "18.830" "22" "6" "6" "6" "354" "38.6" "6.95" "22.98" "6" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf08433" "112970" "ENSG00000198841" "KTI12" "hsa:112970; Q96EK9" "" "" "0" "0" "0.936" "0.963" "0.956" "1.036" "0.949" "0.967" "0.937" "0.868" "1.608" "165.4" "154.9" "159.3" "158.1" "171.4" "157.0" "159.9" "155.0" "143.6" "265.9" "" "" "" "" "" "" "" "" "" "" "148.7" "125.3" "144.1" "154.3" "141.5" "157.0" "119.7" "136.9" "128.5" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8778470671322458913" "False" "High" "IsMasterProtein" "Q71UI9" "Histone H2A.V OS=Homo sapiens OX=9606 GN=H2AZ2 PE=1 SV=3" "0.000" "False" "18.829" "31" "4" "12" "2" "128" "13.5" "10.58" "38.48" "4" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "94239" "ENSG00000105968" "H2AZ2" "A6NFA8; A6NKY0; A6NN01; A8MQC5; hsa:94239; Q59GV8; Q6PK98; Q71UI9" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "Transcriptional regulation by small RNAs; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of the beta-catenin:TCF transactivating complex; RMTs methylate histone arginines; Meiotic synapsis; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Oxidative Stress Induced Senescence; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis" "35" "0" "1.026" "1.001" "0.940" "1.082" "1.093" "0.936" "1.017" "1.023" "1.984" "546.8" "561.2" "547.6" "513.9" "591.8" "597.6" "511.8" "556.0" "559.1" "1085.0" "" "" "" "" "" "" "" "" "" "" "491.7" "454.1" "495.3" "501.6" "488.4" "597.6" "383.2" "491.1" "500.3" "387.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7553626301853439744" "False" "High" "IsMasterProtein" "P63146" "Ubiquitin-conjugating enzyme E2 B OS=Homo sapiens OX=9606 GN=UBE2B PE=1 SV=1" "0.000" "False" "18.824" "24" "2" "5" "1" "152" "17.3" "5.01" "31.17" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00179" "7320" "ENSG00000119048" "UBE2B" "B2R503; D3DQA2; hsa:7320; P23567; P63146; Q4PJ15; Q9D0J6" "Proteasome degradation; Male infertility" "Antigen processing: Ubiquitination & Proteasome degradation; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Recognition of DNA damage by PCNA-containing replication complex" "6" "0" "0.883" "1.096" "0.971" "0.939" "1.000" "0.857" "0.922" "1.174" "0.840" "443.1" "391.3" "485.5" "430.2" "416.3" "443.0" "379.6" "408.7" "520.1" "372.2" "" "" "" "" "" "" "" "" "" "" "398.4" "316.6" "439.2" "419.9" "343.5" "443.0" "284.2" "361.0" "465.4" "132.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "697554350722155722" "False" "High" "IsMasterProtein" "Q96B45" "BLOC-1-related complex subunit 7 OS=Homo sapiens OX=9606 GN=BORCS7 PE=1 SV=2" "0.000" "False" "18.817" "54" "4" "5" "4" "106" "11.7" "6.79" "17.93" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf16088" "119032" "ENSG00000166275" "BORCS7" "B2R488; B3KUW4; C9K0X3; hsa:119032; Q96B45" "" "" "0" "0" "0.926" "1.004" "0.878" "1.029" "1.052" "1.025" "0.982" "1.051" "0.885" "308.2" "285.3" "309.5" "270.5" "317.2" "324.2" "316.0" "302.8" "324.1" "272.9" "" "" "" "" "" "" "" "" "" "" "277.1" "230.8" "280.0" "264.1" "261.8" "324.2" "236.6" "267.5" "290.0" "97.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1418350428187629844" "False" "High" "IsMasterProtein" "O43678" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Homo sapiens OX=9606 GN=NDUFA2 PE=1 SV=3" "0.000" "False" "18.816" "39" "3" "7" "3" "99" "10.9" "9.57" "26.70" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion" "transporter activity" "Pf05047" "4695" "ENSG00000131495" "NDUFA2" "D6RJD6; hsa:4695; O43678; Q6IAY8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "0.903" "0.986" "0.850" "0.975" "0.951" "1.022" "0.983" "0.973" "0.822" "267.7" "241.8" "264.0" "227.6" "260.9" "254.6" "273.5" "263.3" "260.5" "220.0" "" "" "" "" "" "" "" "" "" "" "240.7" "195.6" "238.8" "222.2" "215.3" "254.6" "204.8" "232.6" "233.1" "78.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1655818240381757095" "False" "High" "IsMasterProtein" "Q9NSY1" "BMP-2-inducible protein kinase OS=Homo sapiens OX=9606 GN=BMP2K PE=1 SV=2" "0.000" "False" "18.800" "6" "6" "7" "6" "1161" "129.1" "6.51" "21.50" "6" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf15282" "55589" "ENSG00000138756" "BMP2K" "hsa:55589; O94791; Q4W5H2; Q8IYF2; Q8N2G7; Q8NHG9; Q9NSY1; Q9NTG8" "" "" "0" "0" "1.124" "1.015" "1.095" "1.115" "1.028" "1.045" "1.032" "1.032" "1.278" "167.3" "187.9" "169.8" "183.2" "186.4" "171.9" "174.8" "172.6" "172.6" "213.8" "" "" "" "" "" "" "" "" "" "" "150.4" "152.1" "153.6" "178.8" "153.8" "171.9" "130.9" "152.5" "154.5" "76.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "672780113730382771" "False" "High" "IsMasterProtein" "Q99952" "Tyrosine-protein phosphatase non-receptor type 18 OS=Homo sapiens OX=9606 GN=PTPN18 PE=1 SV=2" "0.000" "False" "18.788" "13" "3" "5" "3" "460" "50.5" "8.25" "28.56" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00102" "26469" "ENSG00000072135" "PTPN18" "B4E1E6; hsa:26469; Q53P42; Q99952" "B cell receptor signaling pathway" "Downregulation of ERBB2 signaling; Interleukin-37 signaling" "3" "0" "1.083" "1.018" "1.006" "1.161" "1.141" "1.154" "1.149" "0.988" "0.925" "93.1" "100.9" "94.8" "93.7" "108.1" "106.2" "107.5" "107.0" "92.0" "86.1" "" "" "" "" "" "" "" "" "" "" "83.7" "81.6" "85.8" "91.5" "89.2" "106.2" "80.5" "94.5" "82.4" "30.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5119048535094086908" "False" "High" "IsMasterProtein" "P82912" "Small ribosomal subunit protein uS11m OS=Homo sapiens OX=9606 GN=MRPS11 PE=1 SV=2" "0.000" "False" "18.780" "20" "5" "6" "5" "194" "20.6" "10.81" "21.31" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00411" "64963" "ENSG00000181991" "MRPS11" "B2RD52; hsa:64963; P82912; Q969D7; Q96GI3; Q9BYC3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.936" "0.880" "0.972" "0.903" "0.977" "0.948" "0.951" "0.902" "1.701" "376.0" "352.0" "330.8" "365.4" "339.7" "367.5" "356.6" "357.8" "339.2" "639.7" "" "" "" "" "" "" "" "" "" "" "338.1" "284.8" "299.2" "356.7" "280.4" "367.5" "267.0" "316.0" "303.5" "228.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7708170732071910709" "False" "High" "IsMasterProtein" "O96013" "Serine/threonine-protein kinase PAK 4 OS=Homo sapiens OX=9606 GN=PAK4 PE=1 SV=1" "0.000" "False" "18.716" "9" "6" "7" "5" "591" "64.0" "9.73" "24.83" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00786" "10298" "ENSG00000130669" "PAK4" "B4DGG6; hsa:10298; O96013; Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8" "Integrin-mediated cell adhesion; Focal adhesion; MET in type 1 papillary renal cell carcinoma; Ras signaling; Pancreatic adenocarcinoma pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Neural crest cell migration during development; Neural crest cell migration in cancer; 22q11.2 copy number variation syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; TROP2 regulatory signaling; ErbB signaling pathway" "RHOG GTPase cycle; RAC2 GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; Activation of RAC1; RHOH GTPase cycle" "25" "0" "1.037" "0.959" "1.014" "1.098" "1.047" "1.010" "1.059" "1.001" "0.902" "682.3" "707.5" "654.3" "691.6" "749.2" "714.3" "688.9" "722.4" "682.7" "615.4" "" "" "" "" "" "" "" "" "" "" "613.5" "572.5" "591.9" "675.1" "618.2" "714.3" "515.8" "638.1" "610.8" "219.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4144026174049458249" "False" "High" "IsMasterProtein" "Q99574" "Neuroserpin OS=Homo sapiens OX=9606 GN=SERPINI1 PE=1 SV=1" "0.000" "False" "18.711" "12" "5" "7" "5" "410" "46.4" "4.91" "22.17" "5" "developmental processes;other biological processes" "non-structural extracellular;other cell component" "enzyme regulator activity" "Pf00079" "5274" "ENSG00000163536" "SERPINI1" "A8K217; D3DNP1; hsa:5274; Q6AHZ4; Q99574" "" "" "0" "0" "0.948" "1.040" "0.969" "0.993" "0.981" "1.008" "0.986" "0.959" "0.897" "288.4" "273.5" "300.0" "279.6" "286.5" "283.1" "290.7" "284.5" "276.7" "258.7" "" "" "" "" "" "" "" "" "" "" "259.3" "221.3" "271.4" "272.9" "236.4" "283.1" "217.7" "251.3" "247.6" "92.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7751322844419777287" "False" "High" "IsMasterProtein" "P33121" "Long-chain-fatty-acid--CoA ligase 1 OS=Homo sapiens OX=9606 GN=ACSL1 PE=1 SV=1" "0.000" "False" "18.697" "10" "6" "6" "6" "698" "77.9" "7.15" "23.16" "6" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00501" "2180" "ENSG00000151726" "ACSL1" "B7Z452; D3DP57; hsa:2180; P33121; P41215; Q8N8V7; Q8TA99" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders; Fatty acids and lipoproteins transport in hepatocytes; Cholesterol biosynthesis pathway in hepatocytes" "PPARA activates gene expression; Synthesis of very long-chain fatty acyl-CoAs; alpha-linolenic acid (ALA) metabolism; Linoleic acid (LA) metabolism" "17" "0" "0.879" "1.035" "0.888" "0.924" "0.890" "0.865" "0.908" "0.895" "0.908" "459.5" "403.8" "475.6" "408.0" "424.5" "408.9" "397.5" "417.2" "411.5" "417.0" "" "" "" "" "" "" "" "" "" "" "413.2" "326.8" "430.2" "398.3" "350.3" "408.9" "297.6" "368.5" "368.2" "148.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4235790517375748562" "False" "High" "IsMasterProtein" "O43924" "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Homo sapiens OX=9606 GN=PDE6D PE=1 SV=1" "0.000" "False" "18.696" "21" "3" "6" "3" "150" "17.4" "5.67" "21.47" "3" "other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf05351" "5147" "ENSG00000156973" "PDE6D" "hsa:5147; O43250; O43924" "Phosphodiesterases in neuronal function; Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "ARL13B-mediated ciliary trafficking of INPP5E; RAS processing" "6" "0" "1.066" "1.089" "1.046" "1.176" "1.099" "1.100" "1.056" "1.096" "1.026" "483.8" "515.7" "527.1" "506.2" "568.9" "531.7" "532.4" "510.9" "530.1" "496.3" "" "" "" "" "" "" "" "" "" "" "435.0" "417.3" "476.8" "494.1" "469.4" "531.7" "398.7" "451.2" "474.3" "177.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1199984255511246690" "False" "High" "IsMasterProtein" "P85037" "Forkhead box protein K1 OS=Homo sapiens OX=9606 GN=FOXK1 PE=1 SV=1" "0.000" "False" "18.673" "9" "5" "6" "5" "733" "75.4" "9.32" "21.78" "5" "other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250, Pf00498" "221937" "ENSG00000164916" "FOXK1" "hsa:221937; P85037" "" "UCH proteinases" "1" "0" "0.938" "0.855" "1.080" "0.981" "0.936" "1.101" "1.006" "1.007" "1.397" "340.7" "319.6" "291.2" "368.0" "334.1" "319.0" "375.1" "342.7" "343.3" "476.0" "" "" "" "" "" "" "" "" "" "" "306.4" "258.6" "263.4" "359.2" "275.7" "319.0" "280.9" "302.7" "307.2" "169.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3672343249527762985" "False" "High" "IsMasterProtein" "Q9H8M7" "Ubiquitin carboxyl-terminal hydrolase MINDY-3 OS=Homo sapiens OX=9606 GN=MINDY3 PE=1 SV=1" "0.000" "False" "18.654" "14" "6" "7" "6" "445" "49.7" "4.77" "18.74" "6" "protein metabolism;other biological processes" "other membranes;nucleus" "other molecular function" "Pf13898" "80013" "ENSG00000148481" "MINDY3" "Q5SZ68; Q5SZ69; Q5SZ70; Q6IA40; Q6P7P0; Q7Z2S1; Q8WUF1; Q9H3I4; Q9H8M7" "" "" "0" "0" "1.050" "1.013" "0.975" "1.049" "0.964" "1.018" "0.964" "1.017" "0.873" "485.0" "509.2" "491.5" "472.8" "509.0" "467.8" "493.5" "467.5" "493.4" "423.6" "" "" "" "" "" "" "" "" "" "" "436.0" "412.1" "444.6" "461.5" "420.0" "467.8" "369.5" "412.9" "441.5" "151.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7984641138409737976" "False" "High" "IsMasterProtein" "Q9BXK5" "Bcl-2-like protein 13 OS=Homo sapiens OX=9606 GN=BCL2L13 PE=1 SV=1" "0.000" "False" "18.641" "15" "6" "8" "6" "485" "52.7" "4.44" "22.36" "6" "other biological processes" "other membranes;mitochondrion;nucleus" "enzyme regulator activity" "Pf00452" "23786" "ENSG00000099968" "BCL2L13" "B3KPE7; hsa:23786; Q96B37; Q96IB7; Q9BXK5; Q9BY01; Q9HC05; Q9UFE0; Q9UKN3" "Regulation of apoptosis by parathyroid hormone-related protein; TAR syndrome" "" "2" "0" "1.045" "1.053" "1.029" "1.173" "0.981" "1.215" "1.024" "1.102" "0.974" "669.9" "700.2" "705.2" "689.1" "785.6" "657.5" "813.7" "686.0" "738.4" "652.3" "" "" "" "" "" "" "" "" "" "" "602.3" "566.5" "637.9" "672.6" "648.3" "657.5" "609.3" "605.9" "660.7" "232.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1153318479582770530" "False" "High" "IsMasterProtein" "P53677" "AP-3 complex subunit mu-2 OS=Homo sapiens OX=9606 GN=AP3M2 PE=1 SV=1" "0.000" "False" "18.622" "13" "6" "6" "3" "418" "46.9" "7.56" "21.41" "6" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf00928, Pf01217" "10947" "ENSG00000070718" "AP3M2" "B2RCR0; D3DSY2; hsa:10947; P53677; Q7Z472" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9020069583805455300" "False" "High" "IsMasterProtein" "O60234" "Glia maturation factor gamma OS=Homo sapiens OX=9606 GN=GMFG PE=1 SV=1" "0.000" "False" "18.616" "23" "3" "10" "2" "142" "16.8" "5.26" "34.90" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00241" "9535" "ENSG00000130755; ENSG00000291873" "GMFG" "hsa:9535; O60234; Q6IB37" "" "Neutrophil degranulation" "1" "0" "1.000" "1.068" "1.054" "1.053" "0.936" "1.023" "1.042" "1.023" "0.961" "399.6" "399.7" "426.9" "421.3" "420.7" "373.9" "408.7" "416.4" "408.7" "384.0" "" "" "" "" "" "" "" "" "" "" "359.3" "323.5" "386.2" "411.2" "347.2" "373.9" "306.1" "367.8" "365.7" "137.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8603881510889965526" "False" "High" "IsMasterProtein" "Q92889" "DNA repair endonuclease XPF OS=Homo sapiens OX=9606 GN=ERCC4 PE=1 SV=3" "0.000" "False" "18.611" "7" "6" "7" "6" "916" "104.4" "6.93" "23.63" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02732" "2072" "ENSG00000175595" "ERCC4" "A5PKV6; A8K111; hsa:2072; O00140; Q8TD83; Q92889" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "8" "0" "1.022" "1.065" "0.955" "1.059" "1.009" "1.034" "0.962" "0.999" "1.242" "278.6" "284.7" "296.6" "266.0" "295.0" "281.1" "288.1" "267.9" "278.3" "345.9" "" "" "" "" "" "" "" "" "" "" "250.4" "230.4" "268.2" "259.6" "243.4" "281.1" "215.8" "236.7" "249.0" "123.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4718065310323386899" "False" "High" "IsMasterProtein" "Q5VSL9" "Striatin-interacting protein 1 OS=Homo sapiens OX=9606 GN=STRIP1 PE=1 SV=1" "0.000" "False" "18.608" "8" "5" "5" "5" "837" "95.5" "6.29" "18.59" "5" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf07923, Pf11882" "85369" "ENSG00000143093" "STRIP1" "hsa:85369; Q0V925; Q5VSL8; Q5VSL9; Q658K2; Q6ZV31; Q8N598; Q96SN2; Q9C0A2" "" "" "0" "0" "1.092" "1.049" "0.957" "1.121" "1.009" "0.988" "1.008" "1.061" "0.981" "259.1" "282.9" "271.7" "247.9" "290.4" "261.4" "255.9" "261.0" "274.8" "254.1" "" "" "" "" "" "" "" "" "" "" "233.0" "228.9" "245.8" "242.0" "239.7" "261.4" "191.6" "230.6" "245.9" "90.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2956258532807354033" "False" "High" "IsMasterProtein" "O00459" "Phosphatidylinositol 3-kinase regulatory subunit beta OS=Homo sapiens OX=9606 GN=PIK3R2 PE=1 SV=2" "0.000" "False" "18.603" "6" "5" "9" "1" "728" "81.5" "6.43" "23.13" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00017, Pf00620, Pf16454" "5296" "ENSG00000105647" "PIK3R2" "hsa:5296; O00459; Q5EAT5; Q9UPH9" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-9 signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Bladder cancer; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; IL6 signaling pathway; TGF-beta signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Synaptic signaling pathways associated with autism spectrum disorder; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Modulators of TCR signaling and T cell activation; Orexin receptor pathway; Regulation of actin cytoskeleton; Alzheimer's disease; G13 signaling pathway; Acute myeloid leukemia; Interferon type I signaling pathways; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Downstream TCR signaling; RND2 GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Signaling by ALK fusions and activated point mutants; RHOU GTPase cycle; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; RND3 GTPase cycle; RND1 GTPase cycle" "113" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8333462526308289964" "False" "High" "IsMasterProtein" "O60671" "Cell cycle checkpoint protein RAD1 OS=Homo sapiens OX=9606 GN=RAD1 PE=1 SV=1" "0.000" "False" "18.559" "22" "6" "7" "6" "282" "31.8" "4.83" "26.02" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02144" "5810" "ENSG00000113456" "RAD1" "hsa:5810; O60671; O75572; O95304; Q1W161; Q5KSM0; Q5KSM1; Q9UEP1" "miRNA regulation of DNA damage response; ATR signaling; DNA damage response" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "10" "0" "1.021" "0.965" "0.874" "0.957" "0.930" "0.941" "0.891" "0.956" "0.879" "673.4" "687.5" "650.0" "588.8" "644.5" "626.6" "633.9" "600.0" "643.7" "591.6" "" "" "" "" "" "" "" "" "" "" "605.4" "556.3" "587.9" "574.7" "531.9" "626.6" "474.6" "530.0" "576.0" "211.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115574768027660471" "False" "High" "IsMasterProtein" "P30837" "Aldehyde dehydrogenase X, mitochondrial OS=Homo sapiens OX=9606 GN=ALDH1B1 PE=1 SV=4" "0.000" "False" "18.557" "9" "4" "7" "3" "517" "57.2" "6.99" "25.16" "4" "other metabolic processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00171" "219" "ENSG00000137124" "ALDH1B1" "B2R8F0; hsa:219; P30837; Q8WX76; Q9BV45" "" "Mitochondrial protein degradation; Ethanol oxidation" "2" "0" "1.032" "0.934" "0.967" "1.122" "1.118" "1.021" "0.976" "1.103" "0.966" "232.3" "239.8" "216.9" "224.6" "260.5" "259.7" "237.1" "226.7" "256.3" "224.4" "" "" "" "" "" "" "" "" "" "" "208.9" "194.0" "196.2" "219.3" "215.0" "259.7" "177.6" "200.2" "229.3" "80.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855179925451267268" "False" "High" "IsMasterProtein" "Q96F24" "Nuclear receptor-binding factor 2 OS=Homo sapiens OX=9606 GN=NRBF2 PE=1 SV=1" "0.000" "False" "18.550" "17" "5" "6" "5" "287" "32.4" "5.87" "21.12" "5" "other metabolic processes;stress response" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08961, Pf17169" "29982" "ENSG00000148572" "NRBF2" "A6PW36; B4DWS0; hsa:29982; Q86UR2; Q96F24; Q96NP6; Q9H0S9; Q9H2I2" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "" "2" "0" "1.003" "1.037" "1.001" "1.048" "1.089" "1.026" "0.999" "1.059" "0.885" "754.5" "756.6" "782.7" "755.0" "790.8" "822.0" "774.4" "753.8" "799.0" "667.4" "" "" "" "" "" "" "" "" "" "" "678.4" "612.2" "708.0" "737.0" "652.6" "822.0" "579.9" "665.8" "715.0" "238.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3974339187776743055" "False" "High" "IsMasterProtein" "Q93074" "Mediator of RNA polymerase II transcription subunit 12 OS=Homo sapiens OX=9606 GN=MED12 PE=1 SV=4" "0.000" "False" "18.550" "4" "8" "8" "8" "2177" "242.9" "7.05" "18.78" "8" "cell-cell signaling;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09497, Pf12144, Pf12145" "9968" "ENSG00000184634" "MED12" "hsa:9968; O15410; O75557; Q93074; Q9UHV6; Q9UND7" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "0.813" "0.888" "0.974" "0.899" "0.916" "0.799" "0.882" "0.866" "0.925" "83.1" "67.6" "73.8" "80.9" "74.7" "76.1" "66.4" "73.3" "71.9" "76.9" "" "" "" "" "" "" "" "" "" "" "74.7" "54.7" "66.7" "79.0" "61.6" "76.1" "49.7" "64.7" "64.4" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3242855938982215798" "False" "High" "IsMasterProtein" "Q9BQP7" "Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1" "0.000" "False" "18.520" "19" "6" "9" "6" "344" "39.4" "7.68" "26.65" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion" "other molecular function" "Pf12705" "92667" "ENSG00000125871" "MGME1" "B2RDG5; D3DW29; hsa:92667; Q96SW3; Q9BQP7" "Primary ovarian insufficiency" "" "1" "0" "0.939" "1.027" "0.998" "0.969" "0.948" "0.921" "0.963" "0.981" "0.822" "635.8" "597.1" "652.7" "634.7" "616.1" "602.5" "585.5" "612.4" "623.4" "522.9" "" "" "" "" "" "" "" "" "" "" "571.6" "483.2" "590.4" "619.6" "508.4" "602.5" "438.4" "540.9" "557.9" "186.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1040458896990308382" "False" "High" "IsMasterProtein" "Q9Y5J7" "Mitochondrial import inner membrane translocase subunit Tim9 OS=Homo sapiens OX=9606 GN=TIMM9 PE=1 SV=1" "0.000" "False" "18.519" "48" "4" "7" "4" "89" "10.4" "7.21" "28.73" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "26520" "ENSG00000100575" "TIMM9" "B2R584; hsa:26520; Q9Y5J7" "" "Mitochondrial protein import; Mitochondrial protein degradation" "2" "0" "1.010" "0.981" "1.045" "1.062" "1.063" "1.081" "1.109" "1.055" "0.775" "1062.2" "1072.8" "1041.7" "1109.8" "1127.6" "1129.3" "1148.0" "1177.8" "1120.7" "822.7" "" "" "" "" "" "" "" "" "" "" "955.0" "868.0" "942.3" "1083.3" "930.5" "1129.3" "859.6" "1040.3" "1002.8" "293.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1788576308263676540" "False" "High" "IsMasterProtein" "Q9BUK6" "Protein misato homolog 1 OS=Homo sapiens OX=9606 GN=MSTO1 PE=1 SV=1" "0.000" "False" "18.481" "9" "5" "6" "5" "570" "61.8" "6.11" "22.24" "5" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion;other cell component" "" "Pf10644, Pf14881" "55154" "ENSG00000125459" "MSTO1" "hsa:55154; Q53GR8; Q5CZ69; Q5T717; Q68CT6; Q7LBZ8; Q7Z3M7; Q7Z558; Q8TE05; Q9BUK6; Q9NQX2; Q9NVU4" "" "" "0" "0" "1.037" "1.015" "0.934" "0.987" "0.913" "1.091" "0.987" "0.901" "1.036" "307.8" "319.3" "312.4" "287.4" "303.8" "280.9" "336.0" "303.9" "277.4" "318.8" "" "" "" "" "" "" "" "" "" "" "276.8" "258.4" "282.5" "280.6" "250.7" "280.9" "251.6" "268.4" "248.2" "113.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3683679323439236664" "False" "High" "IsMasterProtein" "Q6IPR3" "tRNA wybutosine-synthesizing protein 3 homolog OS=Homo sapiens OX=9606 GN=TYW3 PE=1 SV=2" "0.000" "False" "18.450" "23" "6" "8" "6" "259" "29.8" "7.68" "24.14" "6" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf02676" "127253" "ENSG00000162623" "TYW3" "B4DSP9; E9PGR7; hsa:127253; Q5HYJ0; Q6IPR3; Q8N7L1" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.070" "1.058" "1.028" "1.075" "1.055" "1.034" "1.064" "1.084" "1.035" "298.3" "319.1" "315.5" "306.7" "320.6" "314.7" "308.4" "317.5" "323.3" "308.8" "" "" "" "" "" "" "" "" "" "" "268.2" "258.2" "285.4" "299.3" "264.5" "314.7" "230.9" "280.4" "289.3" "110.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6636555355274069790" "False" "High" "IsMasterProtein" "Q9Y5J9" "Mitochondrial import inner membrane translocase subunit Tim8 B OS=Homo sapiens OX=9606 GN=TIMM8B PE=1 SV=1" "0.000" "False" "18.400" "54" "5" "13" "5" "83" "9.3" "5.12" "43.76" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26521" "ENSG00000150779" "TIMM8B" "B0YJA5; hsa:26521; Q3KQS9; Q9UN04; Q9Y5J9" "" "Mitochondrial protein import" "1" "0" "0.988" "0.937" "0.940" "1.033" "1.002" "1.003" "1.046" "0.981" "0.839" "647.6" "640.1" "606.5" "608.4" "669.0" "649.0" "649.7" "677.7" "635.1" "543.2" "" "" "" "" "" "" "" "" "" "" "582.3" "518.0" "548.6" "593.9" "552.1" "649.0" "486.5" "598.6" "568.3" "193.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7216673517695953879" "False" "High" "IsMasterProtein" "Q8TDZ2" "[F-actin]-monooxygenase MICAL1 OS=Homo sapiens OX=9606 GN=MICAL1 PE=1 SV=2" "0.000" "False" "18.387" "5" "5" "5" "5" "1067" "117.8" "6.40" "16.74" "5" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00412, Pf01494, Pf12130" "64780" "ENSG00000135596" "MICAL1" "B7Z3R5; E1P5F0; Q7Z633; Q8IVS9; Q8TDZ2; Q96G47; Q9H6X6; Q9H7I0; Q9HAA1; Q9UFF7" "" "Factors involved in megakaryocyte development and platelet production" "1" "0" "1.111" "1.251" "1.019" "1.139" "1.315" "1.060" "1.245" "1.527" "3.483" "277.9" "308.7" "347.6" "283.1" "316.4" "365.3" "294.7" "346.0" "424.2" "967.7" "" "" "" "" "" "" "" "" "" "" "249.8" "249.8" "314.4" "276.3" "261.1" "365.3" "220.6" "305.6" "379.6" "345.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6159664741780628895" "False" "High" "IsMasterProtein" "Q9P2K3" "REST corepressor 3 OS=Homo sapiens OX=9606 GN=RCOR3 PE=1 SV=2" "0.000" "False" "18.342" "13" "6" "7" "5" "495" "55.5" "8.27" "20.44" "6" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00249, Pf01448, Pf20878" "55758" "ENSG00000117625" "RCOR3" "B3KYA2; B4DYY7; hsa:55758; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83; Q9P2K3" "" "" "0" "0" "0.917" "1.011" "1.038" "0.978" "0.953" "0.979" "0.957" "0.992" "1.437" "304.8" "279.3" "308.1" "316.3" "298.2" "290.6" "298.3" "291.6" "302.5" "437.9" "" "" "" "" "" "" "" "" "" "" "274.0" "226.0" "278.7" "308.7" "246.0" "290.6" "223.4" "257.6" "270.7" "156.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1075701088619798442" "False" "High" "IsMasterProtein" "Q96BZ8" "Leukocyte receptor cluster member 1 OS=Homo sapiens OX=9606 GN=LENG1 PE=1 SV=2" "0.000" "False" "18.340" "14" "4" "5" "4" "264" "30.5" "9.80" "20.50" "4" "" "nucleus" "" "Pf10197" "79165" "ENSG00000105617; ENSG00000275935; ENSG00000276628; ENSG00000276774; ENSG00000276959; ENSG00000277457; ENSG00000277808; ENSG00000278257; ENSG00000278426; ENSG00000278516" "LENG1" "hsa:79165; Q96BZ8; Q9HCU7" "" "mRNA Splicing - Major Pathway" "1" "0" "0.898" "0.884" "0.934" "0.995" "0.924" "1.043" "0.995" "0.942" "0.687" "170.7" "153.3" "151.0" "159.5" "169.9" "157.8" "178.2" "169.8" "160.9" "117.3" "" "" "" "" "" "" "" "" "" "" "153.5" "124.1" "136.5" "155.7" "140.2" "157.8" "133.4" "150.0" "144.0" "41.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1176830711489117496" "False" "High" "IsMasterProtein" "Q7L1V2" "Vacuolar fusion protein MON1 homolog B OS=Homo sapiens OX=9606 GN=MON1B PE=1 SV=1" "0.000" "False" "18.333" "13" "8" "9" "8" "547" "59.2" "6.29" "23.19" "8" "transport;other biological processes" "other cytoplasmic organelle;other cell component" "" "Pf19036, Pf19037, Pf19038" "22879" "ENSG00000103111" "MON1B" "B4DDZ0; hsa:22879; O94949; Q7L1V2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.018" "1.041" "1.092" "1.114" "0.984" "1.139" "1.310" "0.985" "0.680" "34.3" "35.0" "35.8" "37.5" "38.3" "33.8" "39.1" "45.0" "33.8" "23.4" "" "" "" "" "" "" "" "" "" "" "30.9" "28.3" "32.3" "36.6" "31.6" "33.8" "29.3" "39.8" "30.3" "8.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821659264702231707" "False" "High" "IsMasterProtein" "P13284" "Gamma-interferon-inducible lysosomal thiol reductase OS=Homo sapiens OX=9606 GN=IFI30 PE=1 SV=3" "0.000" "False" "18.325" "20" "3" "12" "3" "250" "27.9" "4.88" "27.71" "3" "other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03227" "10437" "ENSG00000216490" "IFI30" "hsa:10437; P13284; Q76MF9; Q8NEI4; Q8WU77; Q9UL08" "" "MHC class II antigen presentation; Interferon gamma signaling" "2" "0" "0.882" "1.092" "0.932" "0.971" "1.216" "1.092" "1.034" "1.055" "0.897" "286.9" "253.2" "313.3" "267.3" "278.5" "348.8" "313.3" "296.6" "302.7" "257.4" "" "" "" "" "" "" "" "" "" "" "258.0" "204.9" "283.4" "260.9" "229.8" "348.8" "234.6" "262.0" "270.8" "91.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8490030146092636123" "False" "High" "IsMasterProtein" "Q7Z422" "SUZ RNA-binding domain-containing OS=Homo sapiens OX=9606 GN=SZRD1 PE=1 SV=1" "0.000" "False" "18.307" "31" "4" "8" "4" "152" "17.0" "8.95" "25.85" "4" "" "" "" "Pf12752, Pf12901" "26099" "ENSG00000055070; ENSG00000291379" "SZRD1" "A8MXJ2; C9K0U0; hsa:26099; Q7Z422; Q7Z424; Q8IVM2; Q8TBV3; Q9Y403" "" "" "0" "0" "1.074" "1.015" "0.909" "1.011" "1.011" "1.104" "1.016" "0.953" "0.882" "568.2" "610.1" "576.8" "516.5" "574.3" "574.7" "627.2" "577.5" "541.3" "501.2" "" "" "" "" "" "" "" "" "" "" "510.8" "493.6" "521.8" "504.2" "474.0" "574.7" "469.6" "510.1" "484.4" "178.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4178938987355296714" "False" "High" "IsMasterProtein" "P62312" "U6 snRNA-associated Sm-like protein LSm6 OS=Homo sapiens OX=9606 GN=LSM6 PE=1 SV=1" "0.000" "False" "18.304" "56" "6" "8" "6" "80" "9.1" "9.58" "24.90" "6" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01423" "11157" "ENSG00000164167" "LSM6" "hsa:11157; P62312; Q4W5J5; Q9Y4Y8" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "0.975" "1.046" "1.147" "0.917" "1.135" "1.008" "1.127" "1.021" "0.648" "886.9" "865.1" "927.3" "1017.0" "813.6" "1007.0" "894.0" "999.3" "905.5" "574.4" "" "" "" "" "" "" "" "" "" "" "797.4" "700.0" "838.8" "992.7" "671.4" "1007.0" "669.4" "882.6" "810.2" "205.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3239366280692976916" "False" "High" "IsMasterProtein" "O14920" "Inhibitor of nuclear factor kappa-B kinase subunit beta OS=Homo sapiens OX=9606 GN=IKBKB PE=1 SV=1" "0.000" "False" "18.286" "11" "8" "9" "8" "756" "86.5" "5.78" "22.45" "8" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "3551" "ENSG00000104365" "IKBKB" "B4DZ30; B4E0U4; hsa:3551; O14920; O75327" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Polycystic kidney disease pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Nonalcoholic fatty liver disease; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; CLEC7A (Dectin-1) signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling" "91" "0" "1.139" "0.991" "0.908" "1.140" "1.074" "1.108" "0.968" "1.004" "1.486" "243.5" "277.3" "241.3" "221.2" "277.7" "261.6" "269.9" "235.8" "244.4" "361.9" "" "" "" "" "" "" "" "" "" "" "218.9" "224.4" "218.3" "215.9" "229.2" "261.6" "202.1" "208.2" "218.7" "129.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1379432049065423837" "False" "High" "IsMasterProtein" "O75143" "Autophagy-related protein 13 OS=Homo sapiens OX=9606 GN=ATG13 PE=1 SV=1" "0.000" "False" "18.278" "16" "6" "8" "6" "517" "56.5" "5.12" "26.91" "6" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf10033" "9776" "ENSG00000175224" "ATG13" "B4DFI4; D3DQQ1; D3DQQ2; E9PQZ8; hsa:9776; O75143; Q53EN6; Q9BRL3; Q9H8B0" "Alzheimer's disease and miRNA effects; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Host-pathogen interaction of human coronaviruses - autophagy; Autophagy; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "12" "0" "1.771" "1.164" "1.135" "1.499" "1.065" "1.234" "1.183" "1.172" "1.093" "193.6" "342.9" "225.3" "219.8" "290.3" "206.2" "238.9" "229.1" "227.0" "211.7" "" "" "" "" "" "" "" "" "" "" "174.1" "277.5" "203.8" "214.5" "239.5" "206.2" "178.9" "202.4" "203.1" "75.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5347375933895697541" "False" "High" "IsMasterProtein" "P06737" "Glycogen phosphorylase, liver form OS=Homo sapiens OX=9606 GN=PYGL PE=1 SV=4" "0.000" "False" "18.269" "6" "5" "6" "2" "847" "97.1" "7.17" "19.34" "5" "other metabolic processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00343" "5836" "ENSG00000100504" "PYGL" "A6NDQ4; B4DUB7; F5H816; hsa:5836; O60567; O60752; O60913; P06737; Q501V9; Q641R5; Q96G82" "TNF-alpha signaling pathway; Glycogen synthesis and degradation; Disorders of galactose metabolism" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis)" "5" "0" "0.936" "0.961" "0.955" "0.919" "0.974" "1.006" "1.077" "0.876" "0.728" "159.2" "149.0" "153.0" "152.1" "146.4" "155.1" "160.2" "171.5" "139.5" "115.9" "" "" "" "" "" "" "" "" "" "" "143.2" "120.6" "138.3" "148.5" "120.8" "155.1" "120.0" "151.5" "124.8" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1783792033634386114" "False" "High" "IsMasterProtein" "Q8N7H5" "RNA polymerase II-associated factor 1 homolog OS=Homo sapiens OX=9606 GN=PAF1 PE=1 SV=2" "0.000" "False" "18.265" "13" "5" "5" "5" "531" "59.9" "4.63" "16.89" "5" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf03985" "54623" "ENSG00000006712" "PAF1" "hsa:54623; M0QX35; O75239; Q8N7H5; Q9H166; Q9NUU9" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "5" "0" "0.964" "0.914" "0.837" "0.982" "0.901" "0.961" "0.884" "0.959" "2.533" "207.0" "199.5" "189.2" "173.2" "203.3" "186.5" "198.8" "183.0" "198.4" "524.3" "" "" "" "" "" "" "" "" "" "" "186.1" "161.4" "171.1" "169.1" "167.8" "186.5" "148.9" "161.6" "177.5" "187.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4846678346596657924" "False" "High" "IsMasterProtein" "Q7L775" "EPM2A-interacting protein 1 OS=Homo sapiens OX=9606 GN=EPM2AIP1 PE=1 SV=1" "0.000" "False" "18.256" "10" "6" "6" "6" "607" "70.3" "6.11" "22.62" "6" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf18658" "9852" "ENSG00000178567" "EPM2AIP1" "hsa:9852; O94866; Q7L775; Q9H3L3" "" "" "0" "0" "1.015" "1.026" "0.878" "1.016" "1.029" "0.957" "0.940" "1.031" "0.985" "326.8" "331.8" "335.2" "286.9" "332.0" "336.2" "312.9" "307.2" "337.1" "321.9" "" "" "" "" "" "" "" "" "" "" "293.8" "268.5" "303.2" "280.0" "273.9" "336.2" "234.3" "271.4" "301.6" "114.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "500960934407520232" "False" "High" "IsMasterProtein" "O43716" "Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Homo sapiens OX=9606 GN=GATC PE=1 SV=1" "0.000" "False" "18.245" "49" "5" "5" "5" "136" "15.1" "5.05" "18.35" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf02686" "283459" "ENSG00000257218" "GATC" "B3KSU7; hsa:283459; O43716; Q3B824; Q3KNR8" "" "" "0" "0" "0.918" "0.951" "0.922" "1.018" "0.956" "1.008" "0.999" "0.917" "1.019" "340.8" "313.0" "324.1" "314.2" "346.9" "325.7" "343.5" "340.5" "312.7" "347.4" "" "" "" "" "" "" "" "" "" "" "306.4" "253.2" "293.1" "306.7" "286.3" "325.7" "257.2" "300.7" "279.8" "124.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "948534183126948466" "False" "High" "IsMasterProtein" "Q8IWE5" "Pleckstrin homology domain-containing family M member 2 OS=Homo sapiens OX=9606 GN=PLEKHM2 PE=1 SV=2" "0.000" "False" "18.220" "7" "5" "5" "5" "1019" "112.7" "4.93" "19.45" "5" "cell organization and biogenesis;stress response;other biological processes" "other membranes;other cytoplasmic organelle" "cytoskeletal activity" "Pf00169, Pf02759" "23207" "ENSG00000116786" "PLEKHM2" "O94928; Q5VT65; Q5VVD7; Q6NUH9; Q7L8G1; Q8IVT7; Q8IWE5; Q8N2T4; Q96AY0; Q9NTF7" "" "" "0" "0" "1.029" "1.106" "0.916" "1.041" "1.074" "1.060" "0.946" "0.958" "0.921" "315.4" "324.6" "348.9" "289.0" "328.5" "338.8" "334.2" "298.4" "302.0" "290.6" "" "" "" "" "" "" "" "" "" "" "283.6" "262.7" "315.6" "282.1" "271.1" "338.8" "250.3" "263.5" "270.3" "103.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7971569862806086425" "False" "High" "IsMasterProtein" "Q9Y2Z4" "Tyrosine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=YARS2 PE=1 SV=2" "0.000" "False" "18.216" "14" "6" "6" "6" "477" "53.2" "8.98" "21.72" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00579" "51067" "ENSG00000139131" "YARS2" "D3DUW8; hsa:51067; Q9H817; Q9Y2Z4" "Orexin receptor pathway" "Mitochondrial tRNA aminoacylation" "2" "0" "0.977" "0.959" "0.896" "1.016" "0.903" "0.916" "0.884" "0.965" "1.915" "662.1" "647.2" "635.2" "593.2" "672.9" "597.9" "606.7" "585.2" "639.1" "1267.7" "" "" "" "" "" "" "" "" "" "" "595.3" "523.7" "574.5" "579.0" "555.3" "597.9" "454.3" "516.9" "571.9" "452.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4229859227879041997" "False" "High" "IsMasterProtein" "P16278" "Beta-galactosidase OS=Homo sapiens OX=9606 GN=GLB1 PE=1 SV=2" "0.000" "False" "18.204" "9" "5" "5" "5" "677" "76.0" "6.57" "17.64" "5" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01301, Pf21317, Pf21467" "2720" "ENSG00000170266" "GLB1" "B2R7H8; B7Z6B0; hsa:2720; P16278; P16279" "Ectoderm differentiation; Degradation pathway of sphingolipids, including diseases; Ciliary landscape; Glycosaminoglycan degradation; Sphingolipid metabolism in senescence" "Neutrophil degranulation; HS-GAG degradation; Sialic acid metabolism; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective NEU1 causes sialidosis; MPS IV - Morquio syndrome B" "12" "0" "1.018" "1.107" "1.031" "1.012" "1.064" "1.070" "1.046" "1.098" "0.999" "394.6" "401.8" "436.6" "406.9" "399.5" "419.8" "422.4" "412.7" "433.3" "394.1" "" "" "" "" "" "" "" "" "" "" "354.8" "325.1" "394.9" "397.2" "329.6" "419.8" "316.3" "364.5" "387.7" "140.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1468504121694453873" "False" "High" "IsMasterProtein" "Q9H930" "Nuclear body protein SP140-like protein OS=Homo sapiens OX=9606 GN=SP140L PE=1 SV=3" "0.000" "False" "18.197" "8" "5" "6" "2" "580" "67.0" "8.48" "23.19" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01342, Pf03172" "93349" "ENSG00000185404" "SP140L" "hsa:93349; Q2M375; Q4ZG65; Q9BSP3; Q9H930" "" "" "0" "0" "0.906" "0.998" "0.963" "1.031" "1.056" "0.935" "0.985" "0.991" "0.916" "174.6" "158.2" "174.2" "168.1" "180.1" "184.4" "163.3" "172.0" "173.0" "160.0" "" "" "" "" "" "" "" "" "" "" "157.0" "128.0" "157.6" "164.1" "148.7" "184.4" "122.3" "152.0" "154.8" "57.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4607067536077994881" "False" "High" "IsMasterProtein" "Q9Y6H1" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Homo sapiens OX=9606 GN=CHCHD2 PE=1 SV=1" "0.000" "False" "18.192" "20" "3" "10" "3" "151" "15.5" "9.22" "37.31" "3" "cell organization and biogenesis;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf06747" "51142" "ENSG00000106153" "CHCHD2" "hsa:51142; Q498C3; Q6NZ50; Q9Y6H1" "Genetic causes of porto-sinusoidal vascular disease" "Mitochondrial protein degradation; Mitochondrial protein import" "3" "0" "0.948" "1.022" "0.959" "1.045" "1.089" "1.020" "1.099" "1.073" "0.865" "1091.4" "1034.5" "1115.2" "1046.6" "1140.8" "1188.9" "1113.0" "1199.5" "1171.0" "943.6" "" "" "" "" "" "" "" "" "" "" "981.3" "837.1" "1008.7" "1021.6" "941.4" "1188.9" "833.4" "1059.5" "1047.8" "336.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058361017873513588" "False" "High" "IsMasterProtein" "P63173" "Large ribosomal subunit protein eL38 OS=Homo sapiens OX=9606 GN=RPL38 PE=1 SV=2" "0.000" "False" "18.175" "41" "4" "9" "4" "70" "8.2" "10.10" "32.19" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01781" "6169" "ENSG00000172809" "RPL38" "B2R5A8; hsa:6169; P23411; P63173" "Mesodermal commitment pathway; Mesodermal commitment pathway; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "16" "0" "0.874" "0.914" "0.939" "0.944" "0.925" "0.871" "0.944" "0.958" "1.104" "944.3" "825.1" "862.7" "886.4" "891.0" "873.1" "822.4" "891.2" "904.7" "1042.4" "" "" "" "" "" "" "" "" "" "" "849.0" "667.6" "780.4" "865.2" "735.3" "873.1" "615.8" "787.2" "809.5" "372.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2026118880241708351" "False" "High" "IsMasterProtein" "A5PLN9" "Trafficking protein particle complex subunit 13 OS=Homo sapiens OX=9606 GN=TRAPPC13 PE=1 SV=2" "0.000" "False" "18.174" "18" "6" "6" "6" "417" "46.5" "5.60" "20.70" "6" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf06159" "80006" "ENSG00000113597" "TRAPPC13" "A5PLN9; hsa:80006; Q17RZ9; Q49A23; Q4JHG0; Q6MZG4; Q8TCM2; Q9H8I3" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.005" "0.926" "0.923" "1.037" "1.074" "0.972" "0.928" "1.008" "1.427" "489.5" "491.8" "453.3" "452.0" "507.7" "525.8" "476.1" "454.5" "493.4" "698.7" "" "" "" "" "" "" "" "" "" "" "440.1" "397.9" "410.1" "441.2" "418.9" "525.8" "356.5" "401.5" "441.5" "249.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3273487821867758056" "False" "High" "IsMasterProtein" "Q96DV4" "Large ribosomal subunit protein mL38 OS=Homo sapiens OX=9606 GN=MRPL38 PE=1 SV=2" "0.000" "False" "18.105" "19" "7" "7" "7" "380" "44.6" "7.53" "25.20" "7" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "" "Pf01161" "64978" "ENSG00000204316" "MRPL38" "B3KN96; hsa:64978; Q96DV4; Q96Q66; Q9P0B9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.983" "1.040" "1.025" "1.066" "1.044" "1.017" "1.012" "1.074" "1.203" "541.9" "532.5" "563.5" "555.7" "577.7" "566.0" "551.1" "548.6" "581.9" "651.8" "" "" "" "" "" "" "" "" "" "" "487.2" "430.8" "509.7" "542.5" "476.7" "566.0" "412.7" "484.6" "520.6" "232.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888778230352659976" "False" "High" "IsMasterProtein" "O14908" "PDZ domain-containing protein GIPC1 OS=Homo sapiens OX=9606 GN=GIPC1 PE=1 SV=2" "0.000" "False" "18.097" "17" "5" "5" "5" "333" "36.0" "6.28" "22.05" "5" "cell-cell signaling;transport;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00595" "10755" "ENSG00000123159" "GIPC1" "A8K4I3; A8MZG3; hsa:10755; O14908; Q9BTC9" "VEGFA-VEGFR2 signaling" "FGFR1b ligand binding and activation; FGFR1c ligand binding and activation" "3" "0" "0.902" "1.027" "0.904" "0.919" "0.985" "0.938" "1.007" "0.976" "1.565" "313.3" "282.5" "321.7" "283.1" "287.8" "308.4" "293.9" "315.5" "305.7" "490.2" "" "" "" "" "" "" "" "" "" "" "281.6" "228.6" "291.0" "276.3" "237.5" "308.4" "220.0" "278.7" "273.6" "175.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1591325911363533533" "False" "High" "IsMasterProtein" "Q8NFV4" "sn-1-specific diacylglycerol lipase ABHD11 OS=Homo sapiens OX=9606 GN=ABHD11 PE=1 SV=2" "0.000" "False" "18.074" "17" "5" "5" "5" "306" "33.7" "9.19" "19.67" "5" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00561" "83451" "ENSG00000106077" "ABHD11" "H7BYM8; hsa:83451; Q6PJU0; Q8N722; Q8N723; Q8NFV2; Q8NFV3; Q8NFV4; Q9HBS8" "7q11.23 copy number variation syndrome" "" "1" "0" "0.984" "1.104" "0.986" "1.064" "1.137" "1.080" "1.087" "1.059" "0.968" "376.2" "370.1" "415.3" "371.0" "400.5" "427.7" "406.5" "409.1" "398.6" "364.3" "" "" "" "" "" "" "" "" "" "" "338.3" "299.5" "375.7" "362.2" "330.5" "427.7" "304.4" "361.4" "356.7" "130.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819543894453362776" "False" "High" "IsMasterProtein" "Q96DA2" "Ras-related protein Rab-39B OS=Homo sapiens OX=9606 GN=RAB39B PE=1 SV=1" "0.000" "False" "18.073" "17" "4" "14" "2" "213" "24.6" "7.83" "36.32" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf00071" "116442" "ENSG00000155961" "RAB39B" "hsa:116442; Q5JT79; Q8NEX3; Q96DA2" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "2" "0" "0.895" "1.031" "0.979" "1.036" "1.096" "1.097" "1.079" "1.046" "0.749" "160.1" "143.3" "165.0" "156.7" "165.9" "175.4" "175.7" "172.8" "167.5" "119.9" "" "" "" "" "" "" "" "" "" "" "144.0" "115.9" "149.3" "153.0" "136.9" "175.4" "131.6" "152.6" "149.9" "42.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107333921582106986" "False" "High" "IsMasterProtein" "Q9UPR3" "Nonsense-mediated mRNA decay factor SMG5 OS=Homo sapiens OX=9606 GN=SMG5 PE=1 SV=3" "0.000" "False" "18.065" "7" "7" "7" "7" "1016" "113.9" "5.91" "16.09" "7" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23381" "ENSG00000198952" "SMG5" "D3DVB7; hsa:23381; Q5QJE7; Q659C7; Q8IXC0; Q8IY09; Q96IJ7; Q9UPR3" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.920" "1.014" "0.961" "1.005" "0.903" "1.016" "0.943" "0.875" "1.527" "370.4" "340.8" "375.5" "355.8" "372.2" "334.5" "376.4" "349.2" "324.2" "565.6" "" "" "" "" "" "" "" "" "" "" "333.1" "275.8" "339.7" "347.3" "307.2" "334.5" "281.8" "308.5" "290.1" "201.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6058304427516802646" "False" "High" "IsMasterProtein" "Q7Z6J9" "tRNA-splicing endonuclease subunit Sen54 OS=Homo sapiens OX=9606 GN=TSEN54 PE=1 SV=3" "0.000" "False" "18.051" "13" "5" "5" "5" "526" "58.8" "7.91" "18.69" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf12928" "283989" "ENSG00000182173" "TSEN54" "hsa:283989; Q7Z6J9; Q86WV3; Q86XE4; Q8N9H2" "" "tRNA processing in the nucleus" "1" "0" "1.227" "1.092" "1.204" "0.989" "1.032" "1.061" "1.026" "1.050" "1.402" "219.1" "269.0" "239.2" "263.7" "216.8" "226.2" "232.5" "224.9" "230.1" "307.1" "" "" "" "" "" "" "" "" "" "" "197.0" "217.6" "216.4" "257.5" "178.9" "226.2" "174.1" "198.6" "205.9" "109.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "115101743397248701" "False" "High" "IsMasterProtein" "Q15528" "Mediator of RNA polymerase II transcription subunit 22 OS=Homo sapiens OX=9606 GN=MED22 PE=1 SV=2" "0.000" "False" "18.046" "33" "6" "8" "6" "200" "22.2" "4.68" "22.93" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf06179" "6837" "ENSG00000148297; ENSG00000281022" "MED22" "B3KW83; B3KWX4; hsa:6837; O76072; Q15528; Q5T8U0" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.964" "1.020" "0.971" "0.989" "1.028" "0.932" "1.044" "1.013" "0.884" "416.1" "401.2" "424.4" "404.1" "411.6" "427.6" "387.7" "434.5" "421.7" "367.9" "" "" "" "" "" "" "" "" "" "" "374.1" "324.6" "383.9" "394.4" "339.6" "427.6" "290.3" "383.7" "377.3" "131.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "123318016964233677" "False" "High" "IsMasterProtein" "O75489" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS3 PE=1 SV=1" "0.000" "False" "18.033" "22" "5" "5" "5" "264" "30.2" "7.50" "19.01" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00329" "4722" "ENSG00000213619" "NDUFS3" "B2R9J1; B4DFM8; hsa:4722; O75489; Q9UNQ8" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis; Mitochondrial protein degradation" "7" "0" "1.026" "1.028" "0.941" "1.081" "1.112" "1.090" "1.088" "1.038" "1.191" "303.4" "311.4" "311.8" "285.4" "327.8" "337.5" "330.8" "330.1" "314.9" "361.2" "" "" "" "" "" "" "" "" "" "" "272.7" "252.0" "282.0" "278.5" "270.5" "337.5" "247.7" "291.5" "281.8" "128.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4927987348987010712" "False" "High" "IsMasterProtein" "P35790" "Choline kinase alpha OS=Homo sapiens OX=9606 GN=CHKA PE=1 SV=3" "0.000" "False" "18.014" "16" "7" "7" "7" "457" "52.2" "6.55" "24.91" "7" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1119" "ENSG00000110721" "CHKA" "hsa:1119; P35790; Q8NE29" "Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Acetylcholine synthesis" "Synthesis of PC; Synthesis of PE" "6" "0" "1.094" "0.949" "0.876" "0.898" "1.041" "0.994" "0.991" "1.057" "1.190" "101.3" "110.8" "96.1" "88.7" "90.9" "105.4" "100.6" "100.3" "107.0" "120.5" "" "" "" "" "" "" "" "" "" "" "91.1" "89.7" "86.9" "86.6" "75.1" "105.4" "75.4" "88.6" "95.8" "43.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1200242617848963307" "False" "High" "IsMasterProtein" "P31749" "RAC-alpha serine/threonine-protein kinase OS=Homo sapiens OX=9606 GN=AKT1 PE=1 SV=2" "0.000" "False" "18.006" "12" "5" "5" "1" "480" "55.7" "6.07" "19.50" "5" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00169, Pf00433" "207" "ENSG00000142208" "AKT1" "B2RAM5; B7Z5R1; hsa:207; P31749; Q9BWB6" "IL-5 signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; Target of rapamycin signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Integrin-mediated cell adhesion; IL-1 signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Apoptosis; Primary focal segmental glomerulosclerosis (FSGS); T cell receptor and co-stimulatory signaling; S1P receptor signal transduction; Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); IL-3 signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Extracellular vesicle-mediated signaling in recipient cells; Kit receptor signaling pathway; Focal adhesion; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; Wnt/beta-catenin signaling pathway in leukemia; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Leptin-insulin signaling overlap; IL-4 signaling pathway; Lipid metabolism pathway; Clear cell renal cell carcinoma pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Endochondral ossification; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Endochondral ossification with skeletal dysplasias; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Kisspeptin/kisspeptin receptor system in the ovary; IL-2 signaling pathway; 3q29 copy number variation syndrome; Modulators of TCR signaling and T cell activation; Kallmann syndrome; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Opioid receptor pathways; CCL18 signaling pathway; Alzheimer's disease; GDNF signaling; Roles of ceramides in development of insulin resistance; Resolvin E1 and resolvin D1 signaling pathways promoting inflammation resolution; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Comprehensive IL-17A signaling; Acute myeloid leukemia; Sildenafil treatment; Primary ovarian insufficiency; IL-26 signaling pathways; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; HDAC6 interactions in the central nervous system; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response; Estrogen signaling pathway; Toll-like receptor signaling pathway" "Deactivation of the beta-catenin transactivating complex; TP53 Regulates Metabolic Genes; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Regulation of PTEN stability and activity; KEAP1-NFE2L2 pathway; Negative regulation of NOTCH4 signaling; RAB GEFs exchange GTP for GDP on RABs; Translocation of SLC2A4 (GLUT4) to the plasma membrane; AKT phosphorylates targets in the nucleus; Constitutive Signaling by AKT1 E17K in Cancer; Regulation of localization of FOXO transcription factors; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; Interleukin-4 and Interleukin-13 signaling; Downregulation of ERBB2:ERBB3 signaling; G beta:gamma signalling through PI3Kgamma; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; AKT phosphorylates targets in the cytosol; Regulation of TP53 Activity through Association with Co-factors; Integrin signaling; VEGFR2 mediated vascular permeability; SARS-CoV-2 targets host intracellular signalling and regulatory pathways; MTOR signalling; FLT3 Signaling; eNOS activation; Regulation of TP53 Activity through Acetylation; KSRP (KHSRP) binds and destabilizes mRNA; RUNX2 regulates genes involved in cell migration; Cyclin E associated events during G1/S transition ; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation; Cyclin A:Cdk2-associated events at S phase entry; CTLA4 inhibitory signaling; PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; Activation of BAD and translocation to mitochondria ; AKT-mediated inactivation of FOXO1A; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "179" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5631999146533429965" "False" "High" "IsMasterProtein" "Q02878" "Large ribosomal subunit protein eL6 OS=Homo sapiens OX=9606 GN=RPL6 PE=1 SV=3" "0.000" "False" "18.004" "20" "7" "10" "7" "288" "32.7" "10.58" "25.20" "7" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01159, Pf03868" "6128" "ENSG00000089009" "RPL6" "hsa:6128; Q02878; Q2M3Q3; Q8WW97" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.012" "0.899" "0.976" "1.119" "1.011" "0.938" "1.060" "0.988" "0.533" "569.3" "575.8" "511.9" "555.6" "637.2" "575.5" "533.9" "603.2" "562.6" "303.7" "" "" "" "" "" "" "" "" "" "" "511.8" "466.0" "463.0" "542.3" "525.8" "575.5" "399.8" "532.8" "503.4" "108.4" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2935309689569447405" "False" "High" "IsMasterProtein" "Q9BYD6" "Large ribosomal subunit protein uL1m OS=Homo sapiens OX=9606 GN=MRPL1 PE=1 SV=2" "0.000" "False" "17.997" "14" "6" "7" "6" "325" "36.9" "8.78" "21.76" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00687" "65008" "ENSG00000169288" "MRPL1" "A6NG03; hsa:65008; Q4W5B8; Q6IAG4; Q96BW3; Q9BYD6; Q9H793; Q9NRL5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.017" "1.019" "0.985" "1.028" "0.951" "1.022" "1.004" "1.042" "1.511" "737.0" "749.2" "750.9" "725.9" "757.9" "701.2" "753.4" "739.8" "767.9" "1113.8" "" "" "" "" "" "" "" "" "" "" "662.6" "606.2" "679.2" "708.6" "625.5" "701.2" "564.1" "653.4" "687.1" "397.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1430598846084428850" "False" "High" "IsMasterProtein" "Q3B726" "DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens OX=9606 GN=POLR1F PE=1 SV=1" "0.000" "False" "17.977" "15" "4" "5" "4" "338" "37.4" "6.98" "17.13" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "Pf03876, Pf17875" "221830" "ENSG00000105849" "POLR1F" "A0PJ45; B7Z724; hsa:221830; Q3B726" "Pyrimidine metabolism; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "7" "0" "1.183" "1.256" "1.216" "1.002" "1.322" "1.126" "1.113" "1.252" "2.687" "80.7" "95.5" "101.4" "98.2" "80.9" "106.7" "90.9" "89.8" "101.1" "216.9" "" "" "" "" "" "" "" "" "" "" "72.6" "77.2" "91.7" "95.8" "66.7" "106.7" "68.0" "79.3" "90.4" "77.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4523012747677362471" "False" "High" "IsMasterProtein" "Q9H0Z9" "RNA-binding protein 38 OS=Homo sapiens OX=9606 GN=RBM38 PE=1 SV=2" "0.000" "False" "17.975" "18" "3" "6" "3" "239" "25.5" "8.65" "28.36" "3" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf00076" "55544" "ENSG00000132819" "RBM38" "A6NDK1; A6NMU6; hsa:55544; Q15350; Q15351; Q9BYK3; Q9BYK4; Q9H0Z9" "" "" "0" "0" "0.897" "0.896" "0.901" "1.358" "0.889" "1.166" "1.015" "0.974" "0.820" "283.6" "254.3" "254.0" "255.5" "385.2" "252.2" "330.6" "287.8" "276.1" "232.5" "" "" "" "" "" "" "" "" "" "" "255.0" "205.7" "229.7" "249.5" "317.9" "252.2" "247.5" "254.2" "247.0" "83.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3162421235115001887" "False" "High" "IsMasterProtein" "L0R819" "ASNSD1 upstream open reading frame protein OS=Homo sapiens OX=9606 GN=ASDURF PE=1 SV=1" "0.000" "False" "17.972" "40" "4" "10" "4" "96" "11.2" "8.88" "35.81" "4" "other biological processes" "other cell component" "" "" "" "ENSG00000286053" "ASDURF" "L0R819" "" "" "0" "0" "0.964" "1.080" "0.991" "1.015" "1.083" "0.984" "1.059" "1.085" "1.015" "1103.2" "1063.4" "1191.5" "1092.8" "1120.3" "1194.3" "1085.6" "1168.2" "1197.0" "1119.9" "" "" "" "" "" "" "" "" "" "" "991.9" "860.5" "1077.7" "1066.7" "924.5" "1194.3" "812.9" "1031.9" "1071.1" "399.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1438891196455375570" "False" "High" "IsMasterProtein" "A9UHW6" "MIF4G domain-containing protein OS=Homo sapiens OX=9606 GN=MIF4GD PE=1 SV=1" "0.000" "False" "17.944" "26" "6" "7" "6" "222" "25.4" "5.33" "24.26" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02854" "57409" "ENSG00000125457" "MIF4GD" "A9UHW6; B4DUM7; hsa:57409; Q8N4Q5; Q9HBL5" "" "" "0" "0" "1.056" "1.000" "1.046" "1.065" "1.099" "1.070" "1.101" "1.051" "1.064" "686.4" "724.9" "686.6" "718.0" "730.7" "754.1" "734.3" "755.5" "721.6" "730.5" "" "" "" "" "" "" "" "" "" "" "617.1" "586.6" "621.1" "700.9" "603.0" "754.1" "549.8" "667.3" "645.7" "260.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "415707649714952015" "False" "High" "IsMasterProtein" "P38398" "Breast cancer type 1 susceptibility protein OS=Homo sapiens OX=9606 GN=BRCA1 PE=1 SV=2" "0.000" "False" "17.934" "3" "7" "7" "7" "1863" "207.6" "5.41" "19.67" "7" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00097, Pf00533, Pf12820" "672" "ENSG00000012048" "BRCA1" "E9PFZ0; hsa:672; O15129; P38398; Q1RMC1; Q3LRJ0; Q3LRJ6; Q6IN79; Q7KYU9" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; Glioblastoma signaling pathways; Hepatitis C and hepatocellular carcinoma; Pathways affected in adenoid cystic carcinoma; PI3K-Akt signaling pathway; Breast cancer pathway; DNA repair pathways, full network; Pleural mesothelioma; Nucleotide excision repair in xeroderma pigmentosum ; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Primary ovarian insufficiency; 5q35 copy number variation; DNA damage response" "Meiotic synapsis; Resolution of D-loop Structures through Holliday Junction Intermediates; Neddylation; KEAP1-NFE2L2 pathway; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; TP53 Regulates Transcription of DNA Repair Genes; Regulation of TP53 Activity through Phosphorylation; Transcriptional Regulation by E2F6; Metalloprotease DUBs; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Nonhomologous End-Joining (NHEJ); Defective DNA double strand break response due to BRCA1 loss of function; Defective DNA double strand break response due to BARD1 loss of function" "40" "0" "1.081" "1.067" "1.080" "1.068" "1.104" "1.098" "1.087" "1.068" "1.412" "459.6" "496.7" "490.4" "496.6" "490.8" "507.5" "504.8" "499.4" "490.7" "649.1" "" "" "" "" "" "" "" "" "" "" "413.2" "401.9" "443.6" "484.7" "405.0" "507.5" "378.0" "441.1" "439.1" "231.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6974141516308557016" "False" "High" "IsMasterProtein" "Q969T9" "WW domain-binding protein 2 OS=Homo sapiens OX=9606 GN=WBP2 PE=1 SV=1" "0.000" "False" "17.926" "17" "4" "7" "4" "261" "28.1" "5.91" "25.32" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02893" "23558" "ENSG00000132471" "WBP2" "B4DFG2; O95638; Q969T9" "" "" "0" "0" "0.939" "0.998" "1.061" "0.962" "1.120" "0.991" "1.037" "1.041" "0.740" "395.6" "371.5" "394.8" "419.7" "380.5" "442.8" "392.2" "410.2" "411.7" "292.6" "" "" "" "" "" "" "" "" "" "" "355.7" "300.6" "357.1" "409.7" "314.0" "442.8" "293.6" "362.3" "368.4" "104.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2991903496179440797" "False" "High" "IsMasterProtein" "A8CG34" "Nuclear envelope pore membrane protein POM 121C OS=Homo sapiens OX=9606 GN=POM121C PE=1 SV=3" "0.000" "False" "17.915" "5" "5" "6" "5" "1229" "125.0" "10.37" "17.49" "5" "transport" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf15229" "" "ENSG00000272391" "POM121C" "A0A075B7F8; A0A087WY75; A8CG34; O75115; Q9Y2N3; Q9Y4S7" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.016" "1.022" "1.091" "0.995" "1.101" "0.997" "0.987" "1.061" "1.192" "447.6" "454.5" "457.3" "488.5" "445.4" "492.8" "446.1" "441.8" "474.8" "533.5" "" "" "" "" "" "" "" "" "" "" "402.4" "367.8" "413.6" "476.8" "367.5" "492.8" "334.0" "390.2" "424.9" "190.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5817906340983341960" "False" "High" "IsMasterProtein" "P61956" "Small ubiquitin-related modifier 2 OS=Homo sapiens OX=9606 GN=SUMO2 PE=1 SV=3" "0.000" "False" "17.913" "29" "3" "13" "1" "95" "10.9" "5.50" "41.82" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11976" "6613" "ENSG00000188612" "SUMO2" "B2R4I2; hsa:6613; P55855; P61956; Q32Q42; Q6IPZ6; Q96HK1" "TAR syndrome" "Formation of Incision Complex in GG-NER; SUMOylation of chromatin organization proteins; SUMOylation of intracellular receptors; SUMOylation of DNA damage response and repair proteins; SUMOylation of SUMOylation proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; Processing of DNA double-strand break ends; Vitamin D (calciferol) metabolism; SUMOylation of transcription factors; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "15" "0" "0.946" "0.912" "0.928" "0.895" "0.929" "0.992" "0.833" "0.781" "0.945" "621.3" "587.5" "566.4" "576.3" "555.8" "577.0" "616.4" "517.5" "484.9" "587.1" "" "" "" "" "" "" "" "" "" "" "558.6" "475.4" "512.4" "562.6" "458.7" "577.0" "461.5" "457.1" "433.9" "209.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6764322891151840328" "False" "High" "IsMasterProtein" "P19484" "Transcription factor EB OS=Homo sapiens OX=9606 GN=TFEB PE=1 SV=3" "0.000" "False" "17.863" "12" "7" "7" "7" "476" "52.8" "6.29" "21.93" "7" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf11851, Pf15951" "7942" "ENSG00000112561" "TFEB" "hsa:7942; P19484; Q709B3; Q7Z6P9; Q9BRJ5; Q9UJD8" "PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Type 2 papillary renal cell carcinoma; Autophagy in pancreatic ductal adenocarcinoma" "" "3" "0" "1.017" "1.008" "1.018" "1.044" "0.977" "1.050" "0.953" "0.941" "2.221" "495.9" "504.3" "499.8" "504.7" "517.8" "484.7" "520.8" "472.5" "466.5" "1101.4" "" "" "" "" "" "" "" "" "" "" "445.8" "408.0" "452.1" "492.7" "427.3" "484.7" "390.0" "417.4" "417.4" "393.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1467078136555344062" "False" "High" "IsMasterProtein" "Q8NHZ8" "Anaphase-promoting complex subunit CDC26 OS=Homo sapiens OX=9606 GN=CDC26 PE=1 SV=1" "0.000" "False" "17.860" "58" "4" "7" "4" "85" "9.8" "6.81" "21.75" "4" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf10471" "246184" "ENSG00000176386" "CDC26" "hsa:246184; Q8NHZ8" "" "Separation of Sister Chromatids; Assembly of the pre-replicative complex; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "18" "0" "0.988" "0.993" "1.004" "1.010" "1.072" "0.951" "1.023" "0.964" "0.980" "411.3" "406.3" "408.5" "413.1" "415.2" "441.1" "391.3" "420.7" "396.5" "403.0" "" "" "" "" "" "" "" "" "" "" "369.8" "328.7" "369.5" "403.3" "342.6" "441.1" "293.0" "371.6" "354.8" "143.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357381019356623363" "False" "High" "IsMasterProtein" "Q15025" "TNFAIP3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TNIP1 PE=1 SV=2" "0.000" "False" "17.854" "9" "6" "7" "6" "636" "71.8" "6.62" "24.44" "6" "cell adhesion;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "" "10318" "ENSG00000145901" "TNIP1" "A4F1W8; A4F1W9; A4F1X2; A4F1X4; A4F1X5; A4F1X6; A4F1X7; A4F1X9; B7Z699; E7EPY1; E7ET96; hsa:10318; O76008; Q05KP3; Q05KP4; Q15025; Q6N077; Q96EL9; Q99833; Q9H1J3" "RAC1/PAK1/p38/MMP2 pathway" "Ovarian tumor domain proteases" "2" "0" "1.173" "1.037" "0.944" "1.144" "1.303" "1.221" "1.052" "1.050" "1.251" "240.6" "282.3" "249.6" "227.1" "275.2" "313.6" "293.7" "253.0" "252.6" "301.0" "" "" "" "" "" "" "" "" "" "" "216.4" "228.4" "225.8" "221.7" "227.1" "313.6" "219.9" "223.5" "226.0" "107.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8017112882834387390" "False" "High" "IsMasterProtein" "Q9Y3C0" "WASH complex subunit 3 OS=Homo sapiens OX=9606 GN=WASHC3 PE=1 SV=1" "0.000" "False" "17.838" "17" "3" "6" "3" "194" "21.2" "4.46" "21.79" "3" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10152" "51019" "ENSG00000120860" "WASHC3" "B2RC74; hsa:51019; Q53FF0; Q6IAI4; Q96QK0; Q9Y3C0" "" "" "0" "0" "1.054" "1.043" "1.094" "1.058" "1.088" "1.123" "1.044" "1.035" "1.137" "339.0" "357.5" "353.7" "371.0" "358.8" "368.9" "380.8" "353.8" "350.9" "385.5" "" "" "" "" "" "" "" "" "" "" "304.8" "289.2" "320.0" "362.2" "296.0" "368.9" "285.1" "312.5" "314.0" "137.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2661255315618113722" "False" "High" "IsMasterProtein" "O43493" "Trans-Golgi network integral membrane protein 2 OS=Homo sapiens OX=9606 GN=TGOLN2 PE=1 SV=4" "0.000" "False" "17.815" "13" "5" "8" "5" "437" "45.9" "5.63" "20.88" "5" "" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle" "" "Pf17818" "10618" "ENSG00000152291; ENSG00000292253" "TGOLN2" "B2R686; B8ZZ88; D6W5K3; F8W8W7; F8WBK2; hsa:10618; J3KQ45; O15282; O43492; O43493; O43499; O43500; O43501; Q53G68; Q53GV2; Q6MZV1; Q6ZTM7; Q8N6T8; Q92760; Q96QL2" "" "Golgi Associated Vesicle Biogenesis; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network" "6" "0" "1.011" "0.910" "1.112" "0.854" "0.994" "1.046" "1.032" "0.963" "0.964" "116.6" "117.8" "106.1" "129.7" "99.6" "116.0" "121.9" "120.4" "112.3" "112.4" "" "" "" "" "" "" "" "" "" "" "104.8" "95.4" "96.0" "126.6" "82.2" "116.0" "91.3" "106.3" "100.5" "40.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268059577032989138" "False" "High" "IsMasterProtein" "Q9NVJ2" "ADP-ribosylation factor-like protein 8B OS=Homo sapiens OX=9606 GN=ARL8B PE=1 SV=1" "0.000" "False" "17.813" "23" "5" "7" "2" "186" "21.5" "8.43" "25.51" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "55207" "ENSG00000134108" "ARL8B" "B4DI85; hsa:55207; Q9NVJ2" "Ciliary landscape" "" "1" "3" "1.183" "1.202" "1.124" "1.200" "1.059" "1.118" "1.131" "1.142" "0.939" "302.4" "357.7" "363.4" "339.9" "363.0" "320.3" "338.0" "342.2" "345.4" "284.0" "" "" "" "" "" "" "" "" "" "" "271.9" "289.4" "328.7" "331.8" "299.5" "320.3" "253.1" "302.2" "309.1" "101.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6553541234872075133" "False" "High" "IsMasterProtein" "Q8N488" "RING1 and YY1-binding protein OS=Homo sapiens OX=9606 GN=RYBP PE=1 SV=2" "0.000" "False" "17.809" "29" "4" "6" "3" "228" "24.8" "9.63" "24.33" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "23429" "ENSG00000163602; ENSG00000281766" "RYBP" "hsa:23429; Q8N488; Q9P2W5; Q9UMW4" "" "Transcriptional Regulation by E2F6; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "2" "1" "0.976" "0.975" "0.999" "0.976" "0.977" "1.014" "1.016" "0.962" "0.864" "274.9" "268.3" "268.0" "274.7" "268.2" "268.5" "278.7" "279.2" "264.5" "237.4" "" "" "" "" "" "" "" "" "" "" "247.1" "217.1" "242.4" "268.1" "221.4" "268.5" "208.7" "246.6" "236.7" "84.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "947873724462567429" "False" "High" "IsMasterProtein" "Q9UNQ2" "Dimethyladenosine transferase OS=Homo sapiens OX=9606 GN=DIMT1 PE=1 SV=1" "0.000" "False" "17.798" "21" "6" "6" "6" "313" "35.2" "9.99" "22.54" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00398" "27292" "ENSG00000086189" "DIMT1" "O76025; Q9BU77; Q9UES1; Q9UNQ2" "" "rRNA modification in the nucleus and cytosol" "1" "0" "1.109" "1.006" "1.005" "1.221" "1.171" "1.073" "1.087" "1.055" "0.954" "233.4" "258.8" "234.7" "234.5" "284.9" "273.4" "250.5" "253.7" "246.2" "222.7" "" "" "" "" "" "" "" "" "" "" "209.8" "209.4" "212.3" "228.9" "235.1" "273.4" "187.6" "224.1" "220.3" "79.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5777043105444546084" "False" "High" "IsMasterProtein" "P00387" "NADH-cytochrome b5 reductase 3 OS=Homo sapiens OX=9606 GN=CYB5R3 PE=1 SV=3" "0.000" "False" "17.794" "17" "4" "5" "4" "301" "34.2" "7.59" "20.76" "4" "other metabolic processes;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00175, Pf00970" "1727" "ENSG00000100243" "CYB5R3" "B1AHF2; B7Z7L3; hsa:1727; O75675; P00387; Q8TDL8; Q8WTS8; Q9UEN4; Q9UEN5; Q9UL55; Q9UL56" "Oxidation by cytochrome P450" "Neutrophil degranulation; Phase I - Functionalization of compounds; Vitamin C (ascorbate) metabolism" "4" "0" "0.976" "0.949" "1.054" "1.067" "0.974" "0.970" "0.996" "1.019" "0.804" "296.3" "289.2" "281.3" "312.4" "316.3" "288.6" "287.5" "295.2" "301.8" "238.1" "" "" "" "" "" "" "" "" "" "" "266.4" "234.0" "254.5" "305.0" "261.0" "288.6" "215.3" "260.7" "270.1" "85.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6666030451106529783" "False" "High" "IsMasterProtein" "Q9NRY2" "SOSS complex subunit C OS=Homo sapiens OX=9606 GN=INIP PE=1 SV=1" "0.000" "False" "17.774" "21" "2" "6" "2" "104" "11.4" "9.25" "23.01" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf15925" "58493" "ENSG00000148153" "INIP" "hsa:58493; Q5VWJ7; Q96E04; Q9NRY2; Q9P090" "" "" "0" "0" "0.921" "0.840" "1.091" "0.791" "0.999" "1.078" "0.912" "1.017" "1.165" "82.4" "75.9" "69.3" "89.9" "65.2" "82.4" "88.9" "75.2" "83.9" "96.1" "" "" "" "" "" "" "" "" "" "" "74.1" "61.4" "62.7" "87.8" "53.8" "82.4" "66.6" "66.4" "75.1" "34.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5045228690157758775" "False" "High" "IsMasterProtein" "Q9Y4E6" "WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=WDR7 PE=1 SV=2" "0.000" "False" "17.769" "4" "6" "8" "6" "1490" "163.7" "6.92" "25.99" "6" "other biological processes" "other cell component" "" "Pf00400" "23335" "ENSG00000091157" "WDR7" "A7E2C8; hsa:23335; Q86UX5; Q86VP2; Q96PS7; Q9Y4E6" "" "" "0" "0" "1.171" "0.919" "0.902" "1.199" "1.178" "1.348" "1.078" "0.989" "1.162" "364.2" "426.6" "334.7" "328.7" "436.6" "428.9" "491.1" "392.6" "360.3" "423.1" "" "" "" "" "" "" "" "" "" "" "327.5" "345.2" "302.8" "320.8" "360.3" "428.9" "367.7" "346.7" "322.4" "151.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-939904416920954895" "False" "High" "IsMasterProtein" "O95271" "Poly [ADP-ribose] polymerase tankyrase-1 OS=Homo sapiens OX=9606 GN=TNKS PE=1 SV=2" "0.000" "False" "17.726" "5" "6" "7" "6" "1327" "142.0" "7.05" "23.95" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00023, Pf00644, Pf07647, Pf13637, Pf13857" "8658" "ENSG00000173273; ENSG00000285372" "TNKS" "hsa:8658; O95271; O95272; Q4G0F2; Q59FX0" "NAD+ biosynthetic pathways; Regulation of Wnt / B-catenin signaling by small molecule compounds; 8p23.1 copy number variation syndrome" "Degradation of AXIN; Ub-specific processing proteases; Regulation of PTEN stability and activity; XAV939 stabilizes AXIN" "8" "0" "1.038" "1.065" "1.016" "1.046" "1.060" "1.003" "1.046" "1.033" "1.253" "624.4" "648.1" "665.3" "634.3" "653.3" "661.6" "626.3" "653.3" "644.9" "782.2" "" "" "" "" "" "" "" "" "" "" "561.4" "524.4" "601.7" "619.2" "539.1" "661.6" "469.0" "577.0" "577.1" "279.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6484824469682462574" "False" "High" "IsMasterProtein" "Q17R31" "Putative deoxyribonuclease TATDN3 OS=Homo sapiens OX=9606 GN=TATDN3 PE=1 SV=1" "0.000" "False" "17.682" "22" "5" "5" "5" "274" "30.3" "7.15" "22.81" "5" "" "nucleus" "other molecular function" "Pf01026" "128387" "ENSG00000203705" "TATDN3" "A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; hsa:128387; Q17R31; Q4G0L1" "" "" "0" "0" "1.021" "1.037" "1.013" "1.108" "0.997" "1.070" "1.023" "0.995" "0.901" "395.9" "404.0" "410.5" "401.1" "438.5" "394.8" "423.7" "405.0" "393.8" "356.5" "" "" "" "" "" "" "" "" "" "" "355.9" "326.9" "371.4" "391.5" "361.8" "394.8" "317.2" "357.7" "352.3" "127.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6137891794897938593" "False" "High" "IsMasterProtein" "Q8NEF9" "Serum response factor-binding protein 1 OS=Homo sapiens OX=9606 GN=SRFBP1 PE=1 SV=1" "0.000" "False" "17.659" "13" "6" "6" "6" "429" "48.6" "9.58" "20.33" "6" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09073" "153443" "ENSG00000151304" "SRFBP1" "hsa:153443; Q5QFI2; Q8NEF9; Q96AH4; Q96DK2" "" "" "0" "0" "0.936" "0.818" "0.982" "0.973" "0.952" "1.037" "0.981" "0.821" "1.146" "592.3" "554.3" "484.7" "581.9" "576.0" "564.0" "614.1" "581.1" "486.0" "678.6" "" "" "" "" "" "" "" "" "" "" "532.5" "448.5" "438.4" "568.0" "475.4" "564.0" "459.8" "513.2" "434.9" "242.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2460427567323238742" "False" "High" "IsMasterProtein" "P05771" "Protein kinase C beta type OS=Homo sapiens OX=9606 GN=PRKCB PE=1 SV=4" "0.000" "False" "17.633" "9" "6" "6" "1" "671" "76.8" "7.01" "20.88" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5579" "ENSG00000166501" "PRKCB" "C5IFJ8; D3DWF5; hsa:5579; O43744; P05127; P05771; Q15138; Q93060; Q9UE49; Q9UE50; Q9UEH8; Q9UJ30; Q9UJ33" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Glioblastoma signaling pathways; B cell receptor signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Common pathways underlying drug addiction; Myometrial relaxation and contraction pathways; Kit receptor signaling pathway; Focal adhesion; G protein signaling pathways; Wnt signaling pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; Serotonin and anxiety-related events; Serotonin and anxiety; PDGFR-beta pathway; Wnt signaling pathway and pluripotency; Ras signaling; Non-small cell lung cancer; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Hippo signaling regulation pathways; Hepatitis B infection; IL-18 signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Orexin receptor pathway; Chronic hyperglycemia impairment of neuron function; Macrophage-stimulating protein (MSP) signaling network map; Calcium regulation in cardiac cells; ErbB signaling pathway" "Activation of NF-kappaB in B cells; G alpha (z) signalling events; Disinhibition of SNARE formation; WNT5A-dependent internalization of FZD4; VEGFR2 mediated cell proliferation; Trafficking of GluR2-containing AMPA receptors; Depolymerization of the Nuclear Lamina; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RHO GTPases Activate NADPH Oxidases" "48" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387955691257056682" "False" "High" "IsMasterProtein" "O43318" "Mitogen-activated protein kinase kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP3K7 PE=1 SV=1" "0.000" "False" "17.626" "6" "4" "5" "4" "606" "67.2" "7.11" "19.12" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714" "6885" "ENSG00000135341" "MAP3K7" "B2RE27; E1P523; hsa:6885; O43317; O43318; O43319; Q5TDN2; Q5TDN3; Q5TDT7; Q9NTR3; Q9NZ70" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Nod-like receptor (NLR) signaling pathway; Fas ligand pathway and stress induction of heat shock proteins; Wnt signaling pathway; IL6 signaling pathway; TGF-beta signaling pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; Wnt signaling pathway and pluripotency; p38 MAPK signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; miRNA role in immune response in sepsis; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - interferon induction; T-cell receptor signaling pathway; DNA damage response (only ATM dependent); Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Ca2+ pathway; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "50" "0" "0.973" "1.190" "1.039" "1.019" "1.097" "1.023" "1.032" "1.171" "1.266" "440.8" "429.1" "524.7" "458.0" "449.3" "483.5" "450.9" "454.9" "516.3" "558.0" "" "" "" "" "" "" "" "" "" "" "396.3" "347.2" "474.6" "447.1" "370.8" "483.5" "337.6" "401.8" "461.9" "199.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1801185171268448485" "False" "High" "IsMasterProtein" "Q6NTE8" "MRN complex-interacting protein OS=Homo sapiens OX=9606 GN=MRNIP PE=1 SV=2" "0.000" "False" "17.622" "17" "5" "5" "5" "343" "37.7" "8.66" "19.56" "5" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf15749" "51149" "ENSG00000161010; ENSG00000283918" "MRNIP" "B5MD09; E9PAK6; Q6NTE8; Q7Z3D8; Q9BUC1; Q9UN54" "" "" "0" "0" "1.036" "1.022" "0.967" "1.002" "1.108" "1.064" "1.048" "1.085" "1.065" "249.0" "258.0" "254.6" "240.8" "249.5" "276.0" "264.9" "260.9" "270.3" "265.1" "" "" "" "" "" "" "" "" "" "" "223.9" "208.8" "230.3" "235.0" "205.9" "276.0" "198.4" "230.5" "241.9" "94.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-379596745727063060" "False" "High" "IsMasterProtein" "Q96CW6" "Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Homo sapiens OX=9606 GN=SLC7A6OS PE=1 SV=2" "0.000" "False" "17.619" "19" "4" "4" "4" "309" "35.0" "4.60" "18.77" "4" "transport;other biological processes" "nucleus;other cell component" "" "Pf08574" "84138" "ENSG00000103061" "SLC7A6OS" "hsa:84138; Q8TCZ3; Q96CW6; Q9H8R8" "" "" "0" "0" "1.007" "0.978" "0.918" "1.023" "1.036" "0.940" "0.942" "1.030" "0.828" "403.1" "406.1" "394.3" "370.2" "412.3" "417.5" "378.9" "379.5" "415.0" "333.9" "" "" "" "" "" "" "" "" "" "" "362.4" "328.6" "356.6" "361.3" "340.2" "417.5" "283.7" "335.2" "371.3" "119.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1411281452547832793" "False" "High" "IsMasterProtein" "Q9UPT9" "Ubiquitin carboxyl-terminal hydrolase 22 OS=Homo sapiens OX=9606 GN=USP22 PE=1 SV=2" "0.000" "False" "17.610" "9" "4" "6" "4" "525" "59.9" "8.05" "22.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00443, Pf02148" "23326" "ENSG00000124422" "USP22" "A0JNS3; hsa:23326; Q2NLE2; Q6MZY4; Q8TBS8; Q96IW5; Q9UPT9" "" "Ub-specific processing proteases; HATs acetylate histones" "2" "0" "1.070" "1.112" "0.925" "1.028" "1.014" "1.154" "0.959" "0.937" "1.643" "315.5" "337.5" "350.9" "291.8" "324.4" "319.8" "364.1" "302.5" "295.6" "518.4" "" "" "" "" "" "" "" "" "" "" "283.6" "273.1" "317.4" "284.8" "267.7" "319.8" "272.6" "267.2" "264.5" "185.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7576893625228470779" "False" "High" "IsMasterProtein" "Q9H410" "Kinetochore-associated protein DSN1 homolog OS=Homo sapiens OX=9606 GN=DSN1 PE=1 SV=2" "0.000" "False" "17.607" "17" "6" "6" "6" "356" "40.0" "7.05" "20.74" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf08202" "79980" "ENSG00000149636" "DSN1" "B4DWT2; E1P5U9; hsa:79980; Q5JW55; Q5JW56; Q9H410; Q9H8P4" "" "Neutrophil degranulation; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.003" "0.991" "0.964" "1.049" "0.972" "1.052" "0.937" "0.965" "0.895" "773.2" "775.2" "766.1" "745.7" "811.2" "751.9" "813.7" "724.5" "746.4" "692.1" "" "" "" "" "" "" "" "" "" "" "695.2" "627.3" "693.0" "727.9" "669.4" "751.9" "609.3" "639.9" "667.9" "247.1" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1838412941252019118" "False" "High" "IsMasterProtein" "Q9Y530" "ADP-ribose glycohydrolase OARD1 OS=Homo sapiens OX=9606 GN=OARD1 PE=1 SV=2" "0.000" "False" "17.596" "27" "4" "6" "4" "152" "17.0" "8.31" "21.57" "4" "protein metabolism;other metabolic processes;stress response" "nucleus;other cell component" "other molecular function" "Pf01661" "221443" "ENSG00000124596" "OARD1" "A6NEK4; A8K4H4; hsa:221443; Q96F23; Q9Y530" "" "" "0" "0" "0.935" "0.884" "0.913" "0.950" "0.805" "0.888" "0.924" "0.783" "1.209" "368.2" "344.1" "325.3" "336.1" "349.8" "296.5" "327.1" "340.2" "288.1" "445.0" "" "" "" "" "" "" "" "" "" "" "331.0" "278.5" "294.3" "328.1" "288.6" "296.5" "244.9" "300.5" "257.8" "158.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4878144000314540155" "False" "High" "IsMasterProtein" "Q9NWU5" "Large ribosomal subunit protein uL22m OS=Homo sapiens OX=9606 GN=MRPL22 PE=1 SV=1" "0.000" "False" "17.589" "28" "5" "6" "5" "206" "23.6" "9.94" "22.39" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00237" "29093" "ENSG00000082515" "MRPL22" "A6NGJ8; hsa:29093; Q5H9Q1; Q96Q51; Q9NWU5; Q9P006" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.055" "1.041" "1.018" "1.061" "1.102" "1.108" "1.040" "0.986" "1.388" "414.3" "437.1" "431.2" "421.8" "439.7" "456.4" "458.8" "430.8" "408.4" "574.8" "" "" "" "" "" "" "" "" "" "" "372.5" "353.7" "390.0" "411.8" "362.8" "456.4" "343.6" "380.5" "365.5" "205.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-621581403936215319" "False" "High" "IsMasterProtein" "Q96B36" "Proline-rich AKT1 substrate 1 OS=Homo sapiens OX=9606 GN=AKT1S1 PE=1 SV=1" "0.000" "False" "17.581" "15" "4" "5" "4" "256" "27.4" "4.75" "18.73" "4" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity" "Pf15798" "84335" "ENSG00000204673" "AKT1S1" "A8MTQ1; B2RE93; hsa:84335; J3KPM3; Q96B36; Q96BI4; Q96IK7; Q96NG2; Q9BWR5" "Target of rapamycin signaling; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Thermogenesis; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Thyroid hormones production and peripheral downstream signaling effects; Autophagy; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP" "Constitutive Signaling by AKT1 E17K in Cancer; mTORC1-mediated signalling; AKT phosphorylates targets in the cytosol; HSF1-dependent transactivation" "22" "0" "0.952" "0.952" "0.963" "1.027" "0.931" "0.984" "1.065" "0.991" "0.914" "649.7" "618.6" "618.7" "625.8" "667.4" "604.9" "639.3" "692.2" "643.9" "593.6" "" "" "" "" "" "" "" "" "" "" "584.1" "500.5" "559.6" "610.9" "550.7" "604.9" "478.7" "611.4" "576.1" "211.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8106966376198238351" "False" "High" "IsMasterProtein" "Q01844" "RNA-binding protein EWS OS=Homo sapiens OX=9606 GN=EWSR1 PE=1 SV=1" "0.000" "False" "17.544" "7" "3" "5" "3" "656" "68.4" "9.33" "19.72" "3" "" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00076, Pf00641" "2130" "ENSG00000182944" "EWSR1" "B0QYK1; hsa:2130; Q01844; Q5THL0; Q92635; Q96FE8; Q96MN4; Q96MX4; Q9BWA2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.019" "1.029" "0.930" "1.217" "1.443" "0.990" "0.950" "0.942" "0.718" "221.7" "226.0" "228.2" "206.2" "269.8" "320.0" "219.6" "210.7" "208.8" "159.1" "" "" "" "" "" "" "" "" "" "" "199.3" "182.9" "206.4" "201.3" "222.7" "320.0" "164.4" "186.1" "186.8" "56.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8560465734379748063" "False" "High" "IsMasterProtein" "Q9NP77" "RNA polymerase II subunit A C-terminal domain phosphatase SSU72 OS=Homo sapiens OX=9606 GN=SSU72 PE=1 SV=1" "0.000" "False" "17.542" "29" "5" "7" "5" "194" "22.6" "5.33" "22.56" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf04722" "29101" "ENSG00000160075" "SSU72" "hsa:29101; Q9BZS6; Q9H933; Q9NP77" "1p36 copy number variation syndrome" "RNA polymerase II transcribes snRNA genes" "2" "0" "0.907" "1.077" "0.932" "0.925" "1.013" "0.988" "0.937" "1.077" "1.089" "363.1" "329.3" "391.2" "338.5" "336.0" "367.7" "358.7" "340.2" "390.9" "395.5" "" "" "" "" "" "" "" "" "" "" "326.5" "266.4" "353.8" "330.4" "277.3" "367.7" "268.6" "300.5" "349.8" "141.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8950408743700017704" "False" "High" "IsMasterProtein" "O60645" "Exocyst complex component 3 OS=Homo sapiens OX=9606 GN=EXOC3 PE=1 SV=3" "0.000" "False" "17.537" "8" "5" "5" "5" "745" "85.5" "6.29" "20.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf06046" "11336" "ENSG00000180104" "EXOC3" "hsa:11336; O60645; Q6P2E8; Q8TEN6; Q8WUW0; Q96DI4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "1.040" "1.083" "0.929" "1.061" "1.006" "1.140" "1.023" "0.980" "2.178" "243.4" "253.2" "263.6" "226.2" "258.2" "244.8" "277.4" "249.0" "238.5" "530.2" "" "" "" "" "" "" "" "" "" "" "218.9" "204.9" "238.4" "220.8" "213.0" "244.8" "207.7" "219.9" "213.4" "189.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2016868097673482949" "False" "High" "IsMasterProtein" "Q9GZY6" "Linker for activation of T-cells family member 2 OS=Homo sapiens OX=9606 GN=LAT2 PE=1 SV=1" "0.000" "False" "17.529" "17" "3" "4" "3" "243" "26.5" "4.78" "17.62" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf15703" "7462" "ENSG00000086730" "LAT2" "A6NFK6; A8K209; A8K4F1; D3DXF9; hsa:7462; Q9BXX8; Q9GZY6; Q9NZY9" "B cell receptor signaling pathway; 7q11.23 copy number variation syndrome" "Role of LAT2/NTAL/LAB on calcium mobilization" "3" "0" "0.984" "0.954" "1.066" "0.994" "1.019" "1.027" "1.045" "0.992" "0.665" "483.0" "475.6" "460.9" "515.0" "480.2" "492.3" "495.9" "505.0" "479.2" "321.2" "" "" "" "" "" "" "" "" "" "" "434.3" "384.8" "416.9" "502.7" "396.3" "492.3" "371.3" "446.1" "428.8" "114.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "765579875042607640" "False" "High" "IsMasterProtein" "Q15843" "NEDD8 OS=Homo sapiens OX=9606 GN=NEDD8 PE=1 SV=1" "0.000" "False" "17.517" "28" "3" "22" "3" "81" "9.1" "8.43" "57.44" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00240" "4738" "ENSG00000129559; ENSG00000285246" "NEDD8" "hsa:4738; Q15843; Q3SXN8; Q6LES6" "EGF/EGFR signaling pathway; 2q37 copy number variation syndrome" "TGF-beta receptor signaling activates SMADs; UCH proteinases; Neddylation; Cargo recognition for clathrin-mediated endocytosis; Iron uptake and transport" "7" "0" "0.943" "0.903" "0.937" "0.888" "1.054" "0.946" "0.939" "0.871" "0.753" "1278.5" "1205.8" "1154.7" "1198.2" "1135.7" "1347.5" "1209.4" "1200.6" "1113.8" "962.7" "" "" "" "" "" "" "" "" "" "" "1149.5" "975.7" "1044.5" "1169.6" "937.2" "1347.5" "905.6" "1060.5" "996.7" "343.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8259676648144024034" "False" "High" "IsMasterProtein" "Q6NT76" "Homeobox-containing protein 1 OS=Homo sapiens OX=9606 GN=HMBOX1 PE=1 SV=1" "0.000" "False" "17.514" "13" "4" "5" "4" "420" "47.2" "6.06" "16.13" "4" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf04814" "79618" "ENSG00000147421" "HMBOX1" "A4K385; A8K3R8; B4DHY5; D3DSU0; hsa:79618; Q3Y6P1; Q6NT76; Q96GS5; Q9H701" "miR-222 in exercise-induced cardiac growth" "" "1" "0" "1.069" "1.029" "0.931" "1.079" "1.180" "1.222" "1.220" "1.178" "1.468" "97.8" "104.6" "100.7" "91.1" "105.5" "115.4" "119.5" "119.3" "115.3" "143.6" "" "" "" "" "" "" "" "" "" "" "87.9" "84.6" "91.1" "88.9" "87.1" "115.4" "89.5" "105.4" "103.1" "51.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2447610796588384838" "False" "High" "IsMasterProtein" "Q96SZ5" "2-aminoethanethiol dioxygenase OS=Homo sapiens OX=9606 GN=ADO PE=1 SV=2" "0.000" "False" "17.487" "21" "7" "9" "7" "270" "29.7" "6.04" "26.97" "7" "stress response" "cytosol" "other molecular function" "Pf07847" "84890" "ENSG00000181915" "ADO" "B1AL29; hsa:84890; Q96SZ5" "" "Degradation of cysteine and homocysteine" "1" "0" "0.944" "0.930" "0.994" "1.000" "0.990" "1.004" "0.946" "0.967" "0.970" "783.1" "739.2" "728.3" "778.3" "783.2" "775.5" "785.9" "741.1" "756.8" "759.7" "" "" "" "" "" "" "" "" "" "" "704.0" "598.1" "658.8" "759.7" "646.3" "775.5" "588.4" "654.6" "677.2" "271.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8204162643568548731" "False" "High" "IsMasterProtein" "Q9HD47" "Ran guanine nucleotide release factor OS=Homo sapiens OX=9606 GN=RANGRF PE=1 SV=1" "0.000" "False" "17.478" "31" "4" "5" "4" "186" "20.4" "4.94" "20.73" "4" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf04603" "29098" "ENSG00000108961" "RANGRF" "D3DTR6; hsa:29098; Q68DI3; Q9BR68; Q9HD47; Q9HD48; Q9NRU9; Q9P001; Q9P0P2" "" "Phase 0 - rapid depolarisation" "1" "0" "1.140" "1.075" "1.015" "0.979" "1.051" "1.078" "1.030" "1.052" "0.935" "126.1" "143.7" "135.5" "128.0" "123.4" "132.4" "135.9" "129.9" "132.6" "117.8" "" "" "" "" "" "" "" "" "" "" "113.3" "116.3" "122.6" "125.0" "101.8" "132.4" "101.8" "114.7" "118.6" "42.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2215661484008569262" "False" "High" "IsMasterProtein" "Q9UBW7" "Zinc finger MYM-type protein 2 OS=Homo sapiens OX=9606 GN=ZMYM2 PE=1 SV=1" "0.000" "False" "17.450" "4" "6" "6" "6" "1377" "154.8" "6.34" "19.84" "6" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf06467, Pf12012" "7750" "ENSG00000121741" "ZMYM2" "A6NDG0; A6NI02; hsa:7750; O43212; O43434; O60898; Q5W0Q4; Q5W0T3; Q63HP0; Q8NE39; Q9H0V5; Q9H538; Q9UBW7; Q9UEU2" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by FLT3 fusion proteins" "3" "0" "0.930" "0.979" "0.786" "0.898" "0.910" "0.954" "0.898" "0.923" "1.514" "567.6" "527.8" "555.7" "446.2" "509.5" "516.5" "541.7" "509.5" "524.1" "859.2" "" "" "" "" "" "" "" "" "" "" "510.3" "427.1" "502.6" "435.5" "420.4" "516.5" "405.6" "450.0" "469.0" "306.7" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "680199301258843894" "False" "High" "IsMasterProtein" "O95229" "ZW10 interactor OS=Homo sapiens OX=9606 GN=ZWINT PE=1 SV=2" "0.000" "False" "17.443" "16" "4" "7" "4" "277" "31.3" "5.15" "20.58" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf15556" "11130" "ENSG00000122952" "ZWINT" "A6NNV6; hsa:11130; O95229; Q0D2I3; Q9BWD0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "1.041" "1.184" "1.032" "1.027" "1.224" "1.056" "0.951" "1.220" "1.516" "412.6" "429.4" "488.6" "425.7" "423.9" "505.1" "435.9" "392.4" "503.5" "625.7" "" "" "" "" "" "" "" "" "" "" "371.0" "347.5" "442.0" "415.5" "349.8" "505.1" "326.4" "346.6" "450.5" "223.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5016840321552797541" "False" "High" "IsMasterProtein" "Q96KP1" "Exocyst complex component 2 OS=Homo sapiens OX=9606 GN=EXOC2 PE=1 SV=1" "0.000" "False" "17.437" "6" "5" "6" "5" "924" "104.0" "6.90" "19.28" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01833, Pf15469" "55770" "ENSG00000112685" "EXOC2" "B2RBE6; hsa:55770; Q5JPC8; Q96AN6; Q96KP1; Q9NUZ8; Q9UJM7" "RalA downstream regulated genes; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "7" "0" "0.986" "0.950" "1.002" "1.010" "1.013" "1.063" "0.987" "1.295" "2.353" "193.7" "191.1" "184.1" "194.0" "195.7" "196.3" "205.9" "191.1" "250.8" "455.9" "" "" "" "" "" "" "" "" "" "" "174.2" "154.6" "166.5" "189.4" "161.5" "196.3" "154.2" "168.8" "224.4" "162.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1632540778200031519" "False" "High" "IsMasterProtein" "Q9BVA0" "Katanin p80 WD40 repeat-containing subunit B1 OS=Homo sapiens OX=9606 GN=KATNB1 PE=1 SV=1" "0.000" "False" "17.431" "8" "5" "6" "5" "655" "72.3" "7.56" "21.78" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00400, Pf13925" "10300" "ENSG00000140854" "KATNB1" "A6NCG6; hsa:10300; O60620; Q9BVA0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "0.945" "0.895" "0.929" "0.989" "0.969" "0.981" "0.925" "0.898" "1.668" "539.8" "510.2" "483.3" "501.7" "533.7" "523.2" "529.5" "499.4" "484.6" "900.2" "" "" "" "" "" "" "" "" "" "" "485.3" "412.9" "437.1" "489.7" "440.4" "523.2" "396.5" "441.1" "433.6" "321.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946118222351064345" "False" "High" "IsMasterProtein" "Q6DD87" "Zinc finger protein 787 OS=Homo sapiens OX=9606 GN=ZNF787 PE=1 SV=4" "0.000" "False" "17.412" "17" "5" "7" "5" "382" "40.4" "7.96" "24.56" "5" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465, Pf13912" "126208" "ENSG00000142409" "ZNF787" "A0A087WUD1; hsa:126208; O00455; Q6DD87" "" "" "0" "0" "0.922" "0.969" "0.784" "0.937" "0.915" "0.955" "0.990" "0.891" "0.970" "143.2" "132.1" "138.7" "112.3" "134.2" "131.0" "136.8" "141.8" "127.6" "139.0" "" "" "" "" "" "" "" "" "" "" "128.8" "106.9" "125.5" "109.6" "110.7" "131.0" "102.4" "125.3" "114.2" "49.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2014146262064774288" "False" "High" "IsMasterProtein" "P09001" "Large ribosomal subunit protein uL3m OS=Homo sapiens OX=9606 GN=MRPL3 PE=1 SV=1" "0.000" "False" "17.394" "15" "6" "7" "6" "348" "38.6" "9.48" "23.81" "6" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00297" "11222" "ENSG00000114686" "MRPL3" "hsa:11222; P09001; Q6IBT2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.018" "0.955" "0.956" "0.888" "0.880" "1.031" "0.916" "0.944" "1.028" "690.5" "703.2" "659.5" "660.3" "613.2" "608.0" "711.9" "632.3" "651.7" "709.9" "" "" "" "" "" "" "" "" "" "" "620.9" "569.0" "596.6" "644.5" "506.1" "608.0" "533.0" "558.5" "583.2" "253.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8660233523405071508" "False" "High" "IsMasterProtein" "A0FGR8" "Extended synaptotagmin-2 OS=Homo sapiens OX=9606 GN=ESYT2 PE=1 SV=1" "0.000" "False" "17.354" "6" "4" "5" "4" "921" "102.3" "9.26" "21.03" "4" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00168, Pf17047" "57488" "ENSG00000117868" "ESYT2" "A0FGR8; A4D229; hsa:57488; Q69YJ2; Q6UKI4; Q6ZTU0; Q6ZVU1; Q9BQS0; Q9NW47; Q9ULJ2" "" "Glycosphingolipid transport" "1" "0" "1.167" "1.020" "1.119" "1.254" "1.112" "1.136" "1.078" "1.151" "1.182" "128.0" "149.4" "130.6" "143.3" "160.6" "142.4" "145.5" "138.0" "147.4" "151.3" "" "" "" "" "" "" "" "" "" "" "115.1" "120.9" "118.1" "139.9" "132.5" "142.4" "108.9" "121.9" "131.9" "54.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5909232235632679983" "False" "High" "IsMasterProtein" "Q13418" "Integrin-linked protein kinase OS=Homo sapiens OX=9606 GN=ILK PE=1 SV=2" "0.000" "False" "17.324" "12" "6" "8" "6" "452" "51.4" "8.07" "23.47" "6" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "kinase activity;other molecular function" "Pf07714, Pf12796" "3611" "ENSG00000166333" "ILK" "B7Z1I0; B7Z418; D3DQU0; hsa:3611; P57043; Q13418; Q68DZ3" "Integrin-mediated cell adhesion; Primary focal segmental glomerulosclerosis (FSGS); Focal adhesion; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; PPAR signaling pathway; Eukaryotic transcription initiation; Endometrial cancer; Acute viral myocarditis; Genes controlling nephrogenesis; Development of ureteric collection system; 2q37 copy number variation syndrome" "Localization of the PINCH-ILK-PARVIN complex to focal adhesions" "13" "0" "1.032" "1.043" "1.017" "1.037" "1.066" "1.072" "0.958" "0.988" "2.708" "370.7" "382.6" "386.7" "377.0" "384.4" "395.3" "397.3" "355.2" "366.2" "1004.1" "" "" "" "" "" "" "" "" "" "" "333.3" "309.6" "349.8" "368.0" "317.2" "395.3" "297.5" "313.8" "327.7" "358.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8080322362920288108" "False" "High" "IsMasterProtein" "Q7Z7F0" "KH homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KHDC4 PE=1 SV=1" "0.000" "False" "17.265" "11" "5" "6" "5" "614" "64.8" "8.73" "23.48" "5" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "" "22889" "ENSG00000132680" "KHDC4" "hsa:22889; O94981; Q7L7Q2; Q7Z7E9; Q7Z7F0; Q8TBQ0" "" "" "0" "0" "1.056" "1.080" "1.071" "1.087" "1.211" "1.239" "1.148" "1.202" "1.277" "167.3" "176.7" "180.7" "179.1" "181.9" "202.6" "207.3" "192.1" "201.0" "213.5" "" "" "" "" "" "" "" "" "" "" "150.4" "143.0" "163.4" "174.8" "150.1" "202.6" "155.2" "169.7" "179.9" "76.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3284671458686948130" "False" "High" "IsMasterProtein" "Q14498" "RNA-binding protein 39 OS=Homo sapiens OX=9606 GN=RBM39 PE=1 SV=2" "0.000" "False" "17.255" "13" "5" "6" "5" "530" "59.3" "10.10" "23.00" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00076, Pf15519" "9584" "ENSG00000131051" "RBM39" "A2RRD3; A5D8W2; B0BLV3; E1P5S0; E1P5S1; hsa:9584; Q14498; Q14499" "VEGFA-VEGFR2 signaling; mRNA processing" "mRNA Splicing - Major Pathway" "3" "0" "1.067" "0.927" "0.927" "0.998" "0.956" "0.954" "0.886" "0.864" "1.204" "257.3" "274.5" "238.5" "238.5" "256.7" "245.9" "245.5" "227.9" "222.4" "309.8" "" "" "" "" "" "" "" "" "" "" "231.3" "222.1" "215.7" "232.8" "211.8" "245.9" "183.8" "201.3" "199.0" "110.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3561433586626158640" "False" "High" "IsMasterProtein" "Q7Z5L2" "Coiled-coil domain-containing protein R3HCC1L OS=Homo sapiens OX=9606 GN=R3HCC1L PE=1 SV=3" "0.000" "False" "17.250" "6" "5" "5" "5" "792" "87.8" "5.16" "18.83" "5" "" "" "" "" "27291" "ENSG00000166024" "R3HCC1L" "hsa:27291; O60598; Q5W0B4; Q5W0B5; Q7Z5L2; Q86VT9; Q8N9H0" "" "" "0" "0" "0.920" "1.020" "1.018" "0.992" "0.932" "1.011" "1.009" "0.953" "1.562" "233.6" "214.9" "238.4" "237.9" "231.7" "217.6" "236.2" "235.7" "222.6" "364.9" "" "" "" "" "" "" "" "" "" "" "210.0" "173.9" "215.6" "232.2" "191.2" "217.6" "176.8" "208.2" "199.2" "130.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5531669477434534246" "False" "High" "IsMasterProtein" "Q9NX01" "Thioredoxin-like protein 4B OS=Homo sapiens OX=9606 GN=TXNL4B PE=1 SV=1" "0.000" "False" "17.230" "33" "5" "7" "5" "149" "17.0" "6.00" "25.55" "5" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf02966" "54957" "ENSG00000140830" "TXNL4B" "D3DWS6; hsa:54957; Q9NX01" "" "" "0" "0" "1.043" "1.069" "0.928" "1.148" "1.028" "1.100" "0.960" "1.040" "1.978" "880.3" "918.4" "940.9" "816.8" "1010.6" "905.4" "968.1" "844.9" "915.9" "1741.5" "" "" "" "" "" "" "" "" "" "" "791.5" "743.1" "851.1" "797.4" "833.9" "905.4" "724.9" "746.3" "819.6" "621.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3637812855525000132" "False" "High" "IsMasterProtein" "Q2KHR2" "DNA-binding protein RFX7 OS=Homo sapiens OX=9606 GN=RFX7 PE=1 SV=2" "0.000" "False" "17.197" "6" "5" "5" "5" "1460" "157.3" "6.61" "16.09" "5" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02257" "64864" "ENSG00000181827" "RFX7" "hsa:64864; Q2KHR2; Q6ZRR1; Q6ZTY6; Q8N3J0; Q9H7A9; Q9H956" "" "" "0" "0" "0.980" "0.899" "1.071" "0.907" "0.814" "0.982" "0.881" "0.893" "2.015" "28.9" "28.3" "26.0" "31.0" "26.2" "23.5" "28.4" "25.4" "25.8" "58.2" "" "" "" "" "" "" "" "" "" "" "26.0" "22.9" "23.5" "30.2" "21.6" "23.5" "21.2" "22.5" "23.1" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1899154642705730358" "False" "High" "IsMasterProtein" "Q9UNK0" "Syntaxin-8 OS=Homo sapiens OX=9606 GN=STX8 PE=1 SV=2" "0.000" "False" "17.186" "28" "6" "6" "6" "236" "26.9" "4.98" "21.47" "6" "cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05739" "9482" "ENSG00000170310" "STX8" "hsa:9482; O60712; Q53XT8; Q9UNK0" "" "" "0" "0" "0.966" "0.917" "0.862" "1.061" "0.958" "1.060" "1.051" "0.967" "0.741" "494.2" "477.4" "453.2" "426.0" "524.2" "473.2" "523.8" "519.2" "477.7" "366.3" "" "" "" "" "" "" "" "" "" "" "444.3" "386.3" "410.0" "415.8" "432.6" "473.2" "392.2" "458.6" "427.4" "130.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4299442073717893558" "False" "High" "IsMasterProtein" "Q9Y6A4" "Cilia- and flagella-associated protein 20 OS=Homo sapiens OX=9606 GN=CFAP20 PE=1 SV=1" "0.000" "False" "17.164" "22" "4" "6" "4" "193" "22.8" "9.76" "22.94" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf05018" "29105" "ENSG00000070761" "CFAP20" "hsa:29105; Q9Y6A4" "" "" "0" "0" "1.073" "1.191" "1.027" "1.090" "1.083" "1.040" "0.945" "1.136" "1.180" "597.3" "641.0" "711.2" "613.3" "651.2" "647.0" "621.4" "564.3" "678.6" "704.6" "" "" "" "" "" "" "" "" "" "" "537.1" "518.7" "643.3" "598.6" "537.4" "647.0" "465.3" "498.4" "607.2" "251.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5610453000666898366" "False" "High" "IsMasterProtein" "Q6RFH5" "WD repeat-containing protein 74 OS=Homo sapiens OX=9606 GN=WDR74 PE=1 SV=1" "0.000" "False" "17.150" "17" "5" "5" "5" "385" "42.4" "8.32" "19.20" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "54663" "ENSG00000133316" "WDR74" "A8K8G5; hsa:54663; Q6RFH5; Q9BRC9; Q9H6X8; Q9NVY2" "" "" "0" "0" "1.127" "1.232" "0.996" "1.050" "1.357" "0.967" "1.010" "1.261" "0.981" "460.8" "519.3" "567.8" "458.8" "483.7" "625.3" "445.6" "465.2" "581.3" "452.1" "" "" "" "" "" "" "" "" "" "" "414.3" "420.2" "513.6" "447.9" "399.2" "625.3" "333.6" "410.9" "520.1" "161.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5432716996293136503" "False" "High" "IsMasterProtein" "P05161" "Ubiquitin-like protein ISG15 OS=Homo sapiens OX=9606 GN=ISG15 PE=1 SV=5" "0.000" "False" "17.146" "31" "4" "8" "4" "165" "17.9" "7.44" "27.33" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00240" "9636" "ENSG00000187608" "ISG15" "hsa:9636; P05161; Q5SVA4; Q7Z2G2; Q96GF0" "Novel intracellular components of RIG-I-like receptor pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Cytosolic DNA-sensing pathway; p53 transcriptional gene network; Extrafollicular and follicular B cell activation by SARS-CoV-2; 1p36 copy number variation syndrome; HDAC6 interactions in the central nervous system; Type II interferon signaling" "RSV-host interactions; PKR-mediated signaling; ISG15 antiviral mechanism; NS1 Mediated Effects on Host Pathways; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Termination of translesion DNA synthesis; Negative regulators of DDX58/IFIH1 signaling" "17" "0" "1.078" "1.032" "0.939" "1.003" "1.013" "1.049" "0.990" "1.018" "1.099" "389.8" "420.1" "402.1" "366.1" "391.1" "395.0" "409.0" "385.8" "396.6" "428.3" "" "" "" "" "" "" "" "" "" "" "350.5" "339.9" "363.7" "357.3" "322.7" "395.0" "306.3" "340.7" "354.9" "152.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1490025525500914879" "False" "High" "IsMasterProtein" "O43929" "Origin recognition complex subunit 4 OS=Homo sapiens OX=9606 GN=ORC4 PE=1 SV=2" "0.000" "False" "17.106" "13" "5" "6" "5" "436" "50.3" "8.00" "18.80" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13191, Pf14629" "5000" "ENSG00000115947" "ORC4" "B7Z3D0; B7Z5F1; D3DP86; F5H069; hsa:5000; O43929; Q96C42" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "0.976" "1.031" "0.977" "0.989" "0.965" "0.992" "1.021" "0.994" "1.609" "370.4" "361.6" "381.9" "362.1" "366.2" "357.6" "367.6" "378.3" "368.2" "596.1" "" "" "" "" "" "" "" "" "" "" "333.1" "292.6" "345.4" "353.4" "302.2" "357.6" "275.3" "334.2" "329.4" "212.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8286530119888385384" "False" "High" "IsMasterProtein" "P36969" "Phospholipid hydroperoxide glutathione peroxidase GPX4 OS=Homo sapiens OX=9606 GN=GPX4 PE=1 SV=3" "0.000" "False" "17.106" "27" "5" "5" "5" "197" "22.2" "8.37" "17.44" "5" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00255" "2879" "ENSG00000167468" "GPX4" "hsa:2879; O43381; P36969; Q6PJ59; Q9UPK2" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; One-carbon metabolism and related pathways; Ferroptosis; Metapathway biotransformation Phase I and II" "Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "11" "0" "1.020" "1.027" "0.945" "1.025" "1.010" "1.006" "0.977" "1.000" "0.908" "646.3" "659.0" "663.6" "610.4" "662.5" "652.6" "650.2" "631.4" "646.5" "586.6" "" "" "" "" "" "" "" "" "" "" "581.1" "533.2" "600.2" "595.9" "546.7" "652.6" "486.9" "557.7" "578.5" "209.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1340431599886036183" "False" "High" "IsMasterProtein" "O60783" "Small ribosomal subunit protein uS14m OS=Homo sapiens OX=9606 GN=MRPS14 PE=1 SV=1" "0.000" "False" "17.085" "29" "3" "5" "3" "128" "15.1" "11.41" "24.63" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00253" "63931" "ENSG00000120333" "MRPS14" "hsa:63931; O60783; Q5R358" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.092" "0.856" "0.931" "1.104" "0.967" "1.106" "0.897" "1.079" "1.377" "157.2" "171.7" "134.7" "146.4" "173.6" "152.0" "173.9" "141.1" "169.7" "216.5" "" "" "" "" "" "" "" "" "" "" "141.4" "138.9" "121.8" "142.9" "143.2" "152.0" "130.2" "124.6" "151.8" "77.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-443661170883717287" "False" "High" "IsMasterProtein" "Q9NQ92" "Coordinator of PRMT5 and differentiation stimulator OS=Homo sapiens OX=9606 GN=COPRS PE=1 SV=3" "0.000" "False" "17.082" "22" "3" "7" "3" "184" "20.1" "4.18" "21.30" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf15340" "55352" "ENSG00000172301" "COPRS" "A6NP14; E1P656; hsa:55352; Q96EF5; Q96P75; Q9NQ92" "NF1 copy number variation syndrome" "RMTs methylate histone arginines" "2" "0" "0.892" "0.959" "0.901" "0.969" "1.020" "0.865" "0.941" "1.043" "0.850" "338.6" "302.0" "324.7" "305.2" "328.2" "345.2" "292.8" "318.6" "353.3" "287.7" "" "" "" "" "" "" "" "" "" "" "304.5" "244.4" "293.7" "297.9" "270.9" "345.2" "219.2" "281.4" "316.2" "102.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1068600970013118283" "False" "High" "IsMasterProtein" "Q99584" "Protein S100-A13 OS=Homo sapiens OX=9606 GN=S100A13 PE=1 SV=1" "0.000" "False" "17.081" "40" "4" "5" "4" "98" "11.5" "6.16" "20.25" "4" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01023" "6284" "ENSG00000189171" "S100A13" "hsa:6284; Q52PI9; Q6FGF8; Q99584" "" "" "0" "0" "0.842" "0.972" "0.893" "0.967" "0.961" "0.975" "0.948" "0.952" "0.856" "788.7" "664.3" "766.6" "704.4" "763.0" "757.8" "768.8" "747.6" "751.0" "674.8" "" "" "" "" "" "" "" "" "" "" "709.1" "537.5" "693.5" "687.6" "629.7" "757.8" "575.7" "660.3" "672.0" "240.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5894079024390586831" "False" "High" "IsMasterProtein" "Q9NQ29" "Putative RNA-binding protein Luc7-like 1 OS=Homo sapiens OX=9606 GN=LUC7L PE=1 SV=1" "0.000" "False" "17.073" "11" "4" "7" "2" "371" "43.7" "9.92" "27.04" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03194" "55692" "ENSG00000007392" "LUC7L" "B8ZZ13; hsa:55692; Q96S32; Q9NPH4; Q9NQ29" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.031" "0.895" "0.977" "0.967" "0.924" "0.985" "1.016" "1.027" "1.029" "233.1" "240.3" "208.7" "227.6" "225.3" "215.4" "229.5" "236.8" "239.5" "239.7" "" "" "" "" "" "" "" "" "" "" "209.6" "194.4" "188.8" "222.2" "185.9" "215.4" "171.9" "209.1" "214.3" "85.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1704471211926066966" "False" "High" "IsMasterProtein" "Q8TEM1" "Nuclear pore membrane glycoprotein 210 OS=Homo sapiens OX=9606 GN=NUP210 PE=1 SV=3" "0.000" "False" "17.008" "2" "3" "5" "3" "1887" "205.0" "6.81" "15.76" "3" "transport" "other membranes;ER/Golgi;nucleus" "" "Pf02368" "23225" "ENSG00000132182" "NUP210" "A6NN56; hsa:23225; O94980; Q6NXG6; Q8NBJ1; Q8TEM1; Q9H6C8; Q9UFP3" "" "Vpr-mediated nuclear import of PICs; Nuclear Pore Complex (NPC) Disassembly; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; snRNP Assembly; Regulation of HSF1-mediated heat shock response; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; HCMV Late Events; SUMOylation of RNA binding proteins; HCMV Early Events; Transcriptional regulation by small RNAs; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "1.018" "0.904" "0.853" "1.128" "0.878" "1.177" "0.982" "0.936" "0.797" "309.1" "314.7" "279.4" "263.6" "348.6" "271.4" "363.9" "303.4" "289.3" "246.3" "" "" "" "" "" "" "" "" "" "" "277.9" "254.6" "252.7" "257.3" "287.6" "271.4" "272.5" "268.0" "258.8" "87.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1014508030414011044" "False" "High" "IsMasterProtein" "P62899" "Large ribosomal subunit protein eL31 OS=Homo sapiens OX=9606 GN=RPL31 PE=1 SV=1" "0.000" "False" "16.999" "35" "6" "7" "6" "125" "14.5" "10.54" "16.12" "6" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01198" "6160" "ENSG00000071082" "RPL31" "B7Z4K2; D3DVJ4; hsa:6160; P12947; P62899; Q53SQ5; Q6IRZ0; Q6LBJ6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.996" "0.914" "0.885" "0.976" "1.039" "0.921" "0.942" "0.956" "0.985" "325.9" "324.6" "297.8" "288.5" "318.2" "338.7" "300.1" "307.0" "311.5" "321.1" "" "" "" "" "" "" "" "" "" "" "293.0" "262.7" "269.4" "281.6" "262.6" "338.7" "224.7" "271.2" "278.8" "114.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6687881647514235914" "False" "High" "IsMasterProtein" "Q147X3" "N-alpha-acetyltransferase 30 OS=Homo sapiens OX=9606 GN=NAA30 PE=1 SV=1" "0.000" "False" "16.984" "15" "4" "5" "4" "362" "39.3" "5.52" "22.12" "4" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00583" "122830" "ENSG00000139977" "NAA30" "hsa:122830; Q0IIN2; Q147X3" "Metapathway biotransformation Phase I and II" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.007" "1.062" "1.105" "1.009" "1.101" "0.950" "1.012" "1.037" "1.096" "269.3" "271.2" "286.0" "297.5" "271.7" "296.4" "255.9" "272.6" "279.3" "295.2" "" "" "" "" "" "" "" "" "" "" "242.1" "219.4" "258.7" "290.4" "224.2" "296.4" "191.6" "240.7" "249.9" "105.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129418023889810362" "False" "High" "IsMasterProtein" "P40429" "Large ribosomal subunit protein uL13 OS=Homo sapiens OX=9606 GN=RPL13A PE=1 SV=2" "0.000" "False" "16.983" "18" "4" "5" "4" "203" "23.6" "10.93" "17.52" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00572" "23521" "ENSG00000142541" "RPL13A" "A8K505; hsa:23521; P40429" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.069" "1.047" "0.938" "1.082" "1.024" "0.964" "1.048" "1.021" "0.768" "447.5" "478.2" "468.5" "419.9" "484.3" "458.0" "431.5" "468.9" "456.9" "343.6" "" "" "" "" "" "" "" "" "" "" "402.3" "387.0" "423.8" "409.9" "399.6" "458.0" "323.1" "414.1" "408.8" "122.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-705908850981217680" "False" "High" "IsMasterProtein" "Q9NWZ5" "Uridine-cytidine kinase-like 1 OS=Homo sapiens OX=9606 GN=UCKL1 PE=1 SV=2" "0.000" "False" "16.980" "12" "6" "7" "6" "548" "61.1" "7.36" "22.79" "6" "other metabolic processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00485, Pf14681" "54963" "ENSG00000198276" "UCKL1" "B7Z8N2; hsa:54963; Q5JWV0; Q70AQ5; Q8N524; Q9H3Z2; Q9NWZ5" "Pyrimidine metabolism" "Pyrimidine salvage" "2" "0" "1.110" "1.074" "0.921" "1.016" "0.972" "1.021" "0.950" "1.067" "1.013" "401.8" "446.2" "431.4" "370.1" "408.1" "390.6" "410.2" "381.8" "428.8" "407.0" "" "" "" "" "" "" "" "" "" "" "361.3" "361.0" "390.2" "361.3" "336.8" "390.6" "307.2" "337.2" "383.7" "145.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5390707735378390925" "False" "High" "IsMasterProtein" "Q8IYB3" "Serine/arginine repetitive matrix protein 1 OS=Homo sapiens OX=9606 GN=SRRM1 PE=1 SV=2" "0.000" "False" "16.974" "6" "5" "6" "5" "904" "102.3" "11.84" "23.29" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity" "Pf01480" "10250" "ENSG00000133226" "SRRM1" "hsa:10250; O60585; Q5VVN4; Q8IYB3" "mRNA processing" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA Splicing - Major Pathway; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "7" "0" "0.891" "0.880" "0.933" "0.908" "0.928" "0.973" "0.892" "0.932" "0.777" "429.6" "382.6" "378.3" "401.0" "390.3" "398.9" "417.9" "383.4" "400.4" "333.9" "" "" "" "" "" "" "" "" "" "" "386.3" "309.6" "342.2" "391.5" "322.0" "398.9" "312.9" "338.7" "358.3" "119.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2737319948807008641" "False" "High" "IsMasterProtein" "Q9H8G2" "Caspase activity and apoptosis inhibitor 1 OS=Homo sapiens OX=9606 GN=CAAP1 PE=1 SV=2" "0.000" "False" "16.963" "20" "5" "5" "5" "361" "38.3" "4.72" "20.05" "5" "other biological processes" "" "" "Pf15335" "79886" "ENSG00000120159" "CAAP1" "B4DWT4; D3DRK4; hsa:79886; Q5VY32; Q6IPE6; Q96C59; Q9H8G2" "Acute viral myocarditis" "" "1" "0" "0.945" "1.003" "1.327" "1.121" "1.093" "1.042" "1.058" "1.131" "1.319" "527.2" "498.0" "528.7" "699.8" "591.1" "576.5" "549.3" "557.7" "596.0" "695.3" "" "" "" "" "" "" "" "" "" "" "474.0" "403.0" "478.2" "683.1" "487.8" "576.5" "411.3" "492.6" "533.3" "248.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3387602003086690885" "False" "High" "IsMasterProtein" "Q9BVC5" "Ashwin OS=Homo sapiens OX=9606 GN=C2orf49 PE=1 SV=1" "0.000" "False" "16.953" "27" "5" "7" "5" "232" "25.8" "9.74" "25.95" "5" "RNA metabolism OR transcription;other metabolic processes;developmental processes" "nucleus;other cell component" "" "Pf15323" "79074" "ENSG00000135974" "C2orf49" "B3KXN3; B4E2G9; hsa:79074; Q9BVC5" "" "tRNA processing in the nucleus" "1" "0" "0.910" "1.040" "0.962" "0.997" "1.010" "1.024" "1.021" "1.016" "0.986" "535.4" "487.3" "556.6" "515.3" "534.0" "540.7" "548.1" "546.8" "544.0" "528.2" "" "" "" "" "" "" "" "" "" "" "481.4" "394.3" "503.4" "503.0" "440.7" "540.7" "410.4" "482.9" "486.8" "188.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3605806557374244366" "False" "High" "IsMasterProtein" "Q99766" "ATP synthase subunit s, mitochondrial OS=Homo sapiens OX=9606 GN=DMAC2L PE=1 SV=4" "0.000" "False" "16.940" "20" "4" "6" "4" "200" "23.2" "7.90" "19.60" "4" "other metabolic processes;transport" "other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "" "27109" "ENSG00000125375" "DMAC2L" "A0A2R8YDJ1; A0A5K1VW60; A8K1U3; D9N156; hsa:27109; Q8WWX3; Q96F77; Q99766" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "1.001" "1.079" "0.973" "1.133" "0.968" "1.109" "1.057" "1.119" "0.996" "515.6" "516.1" "556.4" "501.5" "584.2" "498.8" "571.7" "544.9" "577.1" "513.2" "" "" "" "" "" "" "" "" "" "" "463.5" "417.6" "503.3" "489.6" "482.1" "498.8" "428.1" "481.3" "516.4" "183.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8924414405991965446" "False" "High" "IsMasterProtein" "P98179" "RNA-binding protein 3 OS=Homo sapiens OX=9606 GN=RBM3 PE=1 SV=1" "0.000" "False" "16.919" "35" "4" "7" "4" "157" "17.2" "8.91" "28.95" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity" "Pf00076" "5935" "ENSG00000102317" "RBM3" "hsa:5935; P98179" "" "" "0" "0" "0.895" "0.803" "1.233" "0.889" "1.001" "1.091" "1.139" "0.924" "0.822" "318.5" "285.0" "255.7" "392.5" "283.1" "318.9" "347.4" "362.6" "294.2" "261.8" "" "" "" "" "" "" "" "" "" "" "286.3" "230.6" "231.3" "383.1" "233.6" "318.9" "260.1" "320.2" "263.3" "93.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1665507599286513190" "False" "High" "IsMasterProtein" "P62873" "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homo sapiens OX=9606 GN=GNB1 PE=1 SV=3" "0.000" "False" "16.916" "15" "5" "6" "2" "340" "37.4" "6.00" "21.14" "5" "cell-cell signaling;cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00400" "2782" "ENSG00000078369" "GNB1" "B1AJZ7; hsa:2782; P04697; P04901; P62873; Q1RMY8" "Nicotine effect on dopaminergic neurons; Thyroid stimulating hormone (TSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; 1p36 copy number variation syndrome; Calcium regulation in cardiac cells; Estrogen signaling pathway" "G alpha (i) signalling events; G alpha (z) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Adrenaline,noradrenaline inhibits insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; Glucagon signaling in metabolic regulation; G alpha (q) signalling events; G alpha (12/13) signalling events; Olfactory Signaling Pathway; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1); ADP signalling through P2Y purinoceptor 12; Extra-nuclear estrogen signaling; Sensory perception of sweet, bitter, and umami (glutamate) taste; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Inactivation, recovery and regulation of the phototransduction cascade; Activation of the phototransduction cascade" "45" "3" "1.009" "0.997" "1.014" "0.915" "0.887" "0.939" "1.001" "1.144" "0.891" "793.1" "800.0" "790.4" "804.2" "725.4" "703.2" "744.6" "793.7" "907.5" "706.6" "" "" "" "" "" "" "" "" "" "" "713.0" "647.3" "714.9" "785.0" "598.6" "703.2" "557.5" "701.1" "812.0" "252.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4235528814650407609" "False" "High" "IsMasterProtein" "Q96DT6" "Cysteine protease ATG4C OS=Homo sapiens OX=9606 GN=ATG4C PE=1 SV=1" "0.000" "False" "16.905" "14" "4" "5" "4" "458" "52.5" "5.97" "20.36" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other cell component" "other molecular function" "Pf03416, Pf20166" "84938" "ENSG00000125703" "ATG4C" "A6NLR8; D3DQ58; hsa:84938; Q96DT6; Q96K04" "Clock-controlled autophagy in bone metabolism" "Macroautophagy" "2" "0" "1.048" "1.092" "1.010" "1.182" "1.011" "1.179" "0.926" "0.979" "1.249" "189.0" "198.1" "206.3" "190.9" "223.4" "191.1" "222.8" "175.0" "185.1" "236.0" "" "" "" "" "" "" "" "" "" "" "169.9" "160.3" "186.6" "186.3" "184.4" "191.1" "166.8" "154.6" "165.6" "84.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9066609543119611752" "False" "High" "IsMasterProtein" "Q12851" "Mitogen-activated protein kinase kinase kinase kinase 2 OS=Homo sapiens OX=9606 GN=MAP4K2 PE=1 SV=2" "0.000" "False" "16.864" "10" "5" "5" "5" "820" "91.5" "6.34" "15.81" "5" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00780" "5871" "ENSG00000168067" "MAP4K2" "hsa:5871; Q12851; Q86VU3" "TNF-alpha signaling pathway; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-YAP signaling; Insulin signaling; Pleural mesothelioma" "" "7" "0" "1.185" "1.247" "1.025" "1.060" "1.310" "1.115" "1.206" "0.977" "1.331" "32.5" "38.5" "40.5" "33.3" "34.4" "42.6" "36.2" "39.2" "31.8" "43.3" "" "" "" "" "" "" "" "" "" "" "29.2" "31.2" "36.7" "32.5" "28.4" "42.6" "27.1" "34.6" "28.4" "15.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6821127370945399140" "False" "High" "IsMasterProtein" "Q5JVF3" "PCI domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCID2 PE=1 SV=2" "0.000" "False" "16.861" "16" "6" "6" "6" "399" "46.0" "8.53" "17.73" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01399" "55795" "ENSG00000126226" "PCID2" "A6NK09; hsa:55795; Q3ZCX1; Q5JVF3; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3" "" "" "0" "0" "1.038" "1.050" "0.956" "1.124" "1.024" "1.171" "0.969" "0.965" "2.406" "210.2" "218.2" "220.7" "201.0" "236.3" "215.3" "246.1" "203.6" "202.8" "505.8" "" "" "" "" "" "" "" "" "" "" "189.0" "176.6" "199.7" "196.2" "195.0" "215.3" "184.3" "179.9" "181.4" "180.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265471816786777464" "False" "High" "IsMasterProtein" "Q9Y657" "Spindlin-1 OS=Homo sapiens OX=9606 GN=SPIN1 PE=1 SV=3" "0.000" "False" "16.846" "27" "6" "6" "6" "262" "29.6" "6.96" "21.07" "6" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus" "other molecular function" "Pf02513" "10927" "ENSG00000106723" "SPIN1" "A8K0X6; B3KRQ4; hsa:10927; Q7KZJ8; Q9GZT2; Q9H0N7; Q9Y657" "" "" "0" "0" "1.000" "1.030" "0.989" "1.094" "1.088" "1.059" "0.970" "1.099" "0.889" "255.7" "255.7" "263.4" "252.9" "279.8" "278.1" "270.6" "247.9" "281.0" "227.3" "" "" "" "" "" "" "" "" "" "" "229.9" "206.9" "238.2" "246.9" "230.9" "278.1" "202.6" "219.0" "251.5" "81.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2050370214376890264" "False" "High" "IsMasterProtein" "O76075" "DNA fragmentation factor subunit beta OS=Homo sapiens OX=9606 GN=DFFB PE=1 SV=1" "0.000" "False" "16.841" "13" "4" "5" "4" "338" "39.1" "9.00" "18.09" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02017, Pf09230" "1677" "ENSG00000169598" "DFFB" "hsa:1677; O60521; O76075; Q5SR22; Q9BYI4; Q9BYI5; Q9BYI6" "Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Acute viral myocarditis" "Apoptosis induced DNA fragmentation" "4" "0" "1.012" "0.854" "0.887" "0.983" "0.893" "1.004" "0.974" "1.060" "0.971" "227.4" "230.1" "194.2" "201.8" "223.6" "203.2" "228.3" "221.5" "241.1" "220.8" "" "" "" "" "" "" "" "" "" "" "204.5" "186.2" "175.6" "196.9" "184.5" "203.2" "170.9" "195.7" "215.8" "78.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2894972574115964479" "False" "High" "IsMasterProtein" "P11234" "Ras-related protein Ral-B OS=Homo sapiens OX=9606 GN=RALB PE=1 SV=1" "0.000" "False" "16.841" "29" "5" "5" "2" "206" "23.4" "6.62" "17.94" "5" "cell cycle OR cell proliferation;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00071" "5899" "ENSG00000144118" "RALB" "B4E040; hsa:5899; P11234; Q53T32; Q6ZS74" "Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Pancreatic adenocarcinoma pathway; Ciliary landscape; EGF/EGFR signaling pathway" "p38MAPK events" "6" "2" "1.077" "1.016" "1.048" "0.994" "0.946" "0.996" "0.987" "1.072" "0.832" "423.0" "455.7" "429.8" "443.2" "420.5" "400.0" "421.2" "417.3" "453.3" "351.8" "" "" "" "" "" "" "" "" "" "" "380.3" "368.8" "388.7" "432.6" "347.0" "400.0" "315.4" "368.6" "405.6" "125.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5483705117675463598" "False" "High" "IsMasterProtein" "P10321" "HLA class I histocompatibility antigen, C alpha chain OS=Homo sapiens OX=9606 GN=HLA-C PE=1 SV=3" "0.000" "False" "16.828" "19" "5" "5" "3" "366" "40.6" "6.04" "18.58" "5" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00129, Pf06623, Pf07654" "3107" "ENSG00000204525" "HLA-C" "hsa:3107; O02863; O02864; O02865; O02866; O02958; O19505; O19652; O19676; O62879; O62882; O62883; O62888; O78060; O78061; O78062; O78063; O78067; O78068; O78069; O78072; O78083; O78090; O78091; O78149; O78165; O78166; O78178; O78202; O78203; O78211; O78214; P04222; P10321; P30499; P30500; P30501; P30502; P30503; P30504; P30505; P30506; P30507; P30508; P30509; P30510; P79498; Q07000; Q29631; Q29641; Q29643; Q29652; Q29743; Q29768; Q29862; Q29864; Q29865; Q29867; Q29921; Q29959; Q29960; Q29963; Q29986; Q29989; Q29990; Q29991; Q29992; Q29993; Q30192; Q31605; Q31627; Q860R1; Q860R2; Q95463; Q95603; Q95604; Q99528; Q9BD28; Q9GIK4; Q9GIK8; Q9GJ33; Q9MY30; Q9MY31; Q9MY35; Q9MY49; Q9MY74; Q9MYI3; Q9TNN7; Q9TNZ8; Q9TPS4; Q9TPV8; Q9TPX2; Q9TQB4; Q9TQJ5; Q9TQP9; Q9UM32; Q9UM33; Q9UM42; Q9UQS9" "Proteasome degradation; Allograft rejection; Ebola virus infection in host; TAR syndrome" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interferon alpha/beta signaling; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; ER-Phagosome pathway; DAP12 interactions; Neutrophil degranulation; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Endosomal/Vacuolar pathway" "13" "2" "1.060" "1.158" "1.066" "1.094" "1.278" "1.125" "1.131" "1.279" "1.074" "301.3" "319.5" "348.9" "321.3" "329.7" "385.1" "338.9" "340.7" "385.5" "323.6" "" "" "" "" "" "" "" "" "" "" "270.9" "258.5" "315.6" "313.6" "272.1" "385.1" "253.8" "300.9" "344.9" "115.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036911108115043510" "False" "High" "IsMasterProtein" "Q96F86" "Enhancer of mRNA-decapping protein 3 OS=Homo sapiens OX=9606 GN=EDC3 PE=1 SV=1" "0.000" "False" "16.807" "12" "6" "6" "6" "508" "56.0" "7.11" "18.58" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf03853, Pf09532, Pf12701, Pf16598" "80153" "ENSG00000179151" "EDC3" "B3KPH0; D3DW61; hsa:80153; Q96F86; Q9H797" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.035" "1.079" "0.998" "1.019" "1.129" "1.196" "1.155" "1.148" "2.058" "374.0" "387.3" "403.6" "373.4" "381.3" "422.4" "447.2" "432.0" "429.4" "769.9" "" "" "" "" "" "" "" "" "" "" "336.3" "313.4" "365.0" "364.5" "314.7" "422.4" "334.8" "381.6" "384.2" "274.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8396834273640286125" "False" "High" "IsMasterProtein" "O75695" "Protein XRP2 OS=Homo sapiens OX=9606 GN=RP2 PE=1 SV=4" "0.000" "False" "16.794" "19" "6" "6" "6" "350" "39.6" "5.12" "21.99" "6" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07986" "6102" "ENSG00000102218" "RP2" "hsa:6102; O75695; Q86XJ7; Q9NU67" "Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "Trafficking of myristoylated proteins to the cilium" "4" "0" "0.983" "1.134" "0.934" "0.998" "1.003" "1.020" "0.866" "0.980" "0.684" "469.6" "461.5" "532.4" "438.7" "468.6" "471.2" "479.0" "406.6" "460.0" "321.0" "" "" "" "" "" "" "" "" "" "" "422.2" "373.4" "481.6" "428.2" "386.7" "471.2" "358.6" "359.1" "411.6" "114.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5312560653861073020" "False" "High" "IsMasterProtein" "P82932" "Small ribosomal subunit protein bS6m OS=Homo sapiens OX=9606 GN=MRPS6 PE=1 SV=3" "0.000" "False" "16.784" "26" "3" "5" "3" "125" "14.2" "9.26" "19.13" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01250" "64968" "ENSG00000243927" "MRPS6" "B2R573; hsa:64968; P82932; Q96Q64; Q9BSK8; Q9BW89" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.984" "0.994" "1.013" "0.995" "1.036" "1.044" "1.000" "0.987" "1.277" "667.2" "656.7" "663.1" "675.7" "663.9" "691.3" "696.8" "667.2" "658.8" "852.0" "" "" "" "" "" "" "" "" "" "" "599.9" "531.4" "599.8" "659.6" "547.8" "691.3" "521.8" "589.4" "589.5" "304.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3735327687387277491" "False" "High" "IsMasterProtein" "Q16254" "Transcription factor E2F4 OS=Homo sapiens OX=9606 GN=E2F4 PE=1 SV=2" "0.000" "False" "16.784" "14" "6" "6" "6" "413" "43.9" "4.75" "21.00" "6" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf16421" "1874" "ENSG00000205250" "E2F4" "A6NGR8; B5BU56; hsa:1874; Q12991; Q15328; Q16254" "Cell cycle; Adipogenesis; TGF-beta signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; Alstrom syndrome" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Cyclin D associated events in G1; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "14" "0" "1.048" "0.937" "0.947" "1.083" "1.705" "1.035" "1.088" "0.966" "1.186" "261.4" "273.9" "245.0" "247.5" "283.2" "445.8" "270.5" "284.5" "252.5" "310.2" "" "" "" "" "" "" "" "" "" "" "235.1" "221.6" "221.6" "241.5" "233.7" "445.8" "202.6" "251.3" "225.9" "110.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5973761010667615261" "False" "High" "IsMasterProtein" "Q86Y07" "Serine/threonine-protein kinase VRK2 OS=Homo sapiens OX=9606 GN=VRK2 PE=1 SV=3" "0.000" "False" "16.753" "8" "4" "5" "4" "508" "58.1" "8.84" "18.50" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "7444" "ENSG00000028116" "VRK2" "B4DKL0; D6W5D4; D6W5D6; hsa:7444; Q49AK9; Q53EU9; Q53S39; Q53S77; Q53TU1; Q86Y07; Q86Y08; Q86Y09; Q86Y10; Q86Y11; Q86Y12; Q8IXI5; Q99987" "" "RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle" "5" "0" "0.978" "0.981" "0.901" "0.956" "1.044" "0.920" "0.969" "0.999" "0.896" "305.5" "298.7" "299.6" "275.4" "292.2" "319.1" "281.0" "296.0" "305.2" "273.8" "" "" "" "" "" "" "" "" "" "" "274.7" "241.7" "271.0" "268.8" "241.1" "319.1" "210.4" "261.4" "273.1" "97.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4937271554403891889" "False" "High" "IsMasterProtein" "P16150" "Leukosialin OS=Homo sapiens OX=9606 GN=SPN PE=1 SV=1" "0.000" "False" "16.702" "12" "5" "8" "5" "400" "40.3" "5.10" "26.17" "5" "cell adhesion;cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "" "6693" "ENSG00000197471" "SPN" "A8K9B1; hsa:6693; P16150" "16p11.2 proximal deletion syndrome" "Basigin interactions" "3" "0" "0.960" "0.875" "0.969" "0.963" "0.953" "1.043" "0.959" "0.899" "0.693" "712.0" "683.7" "622.7" "689.6" "685.7" "678.7" "742.5" "683.1" "640.3" "493.1" "" "" "" "" "" "" "" "" "" "" "640.1" "553.2" "563.3" "673.2" "565.8" "678.7" "556.0" "603.3" "572.9" "176.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-888035968268434758" "False" "High" "IsMasterProtein" "Q9Y3B2" "Exosome complex component CSL4 OS=Homo sapiens OX=9606 GN=EXOSC1 PE=1 SV=1" "0.000" "False" "16.675" "30" "5" "5" "5" "195" "21.4" "8.24" "20.55" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity" "Pf10447, Pf14382" "51013" "ENSG00000171311" "EXOSC1" "B2R9B3; hsa:51013; Q5JTH3; Q9Y3B2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; ATF4 activates genes in response to endoplasmic reticulum stress; KSRP (KHSRP) binds and destabilizes mRNA; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA; mRNA decay by 3' to 5' exoribonuclease" "6" "0" "1.110" "1.142" "1.009" "1.196" "1.289" "1.130" "1.044" "1.275" "1.152" "285.1" "316.3" "325.5" "287.6" "340.9" "367.4" "322.2" "297.6" "363.4" "328.3" "" "" "" "" "" "" "" "" "" "" "256.3" "256.0" "294.4" "280.8" "281.4" "367.4" "241.3" "262.9" "325.2" "117.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4925331307854051957" "False" "High" "IsMasterProtein" "Q14739" "Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2" "0.000" "False" "16.668" "6" "5" "9" "5" "615" "70.7" "9.36" "26.50" "5" "other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01222, Pf09465" "3930" "ENSG00000143815" "LBR" "B2R5P3; hsa:3930; Q14739; Q14740; Q53GU7; Q59FE6" "Gastric cancer network 2; Envelope proteins and their potential roles in EDMD physiopathology; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol synthesis disorders; Cholesterol metabolism; Enterocyte cholesterol metabolism" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RHOC GTPase cycle; RHOA GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; Regulation of MECP2 expression and activity; Initiation of Nuclear Envelope (NE) Reformation; Cholesterol biosynthesis" "18" "0" "1.085" "0.887" "1.015" "1.058" "0.958" "1.160" "0.992" "0.858" "1.023" "663.9" "720.2" "589.1" "673.9" "702.4" "635.9" "770.0" "658.8" "569.5" "679.5" "" "" "" "" "" "" "" "" "" "" "596.9" "582.8" "532.8" "657.8" "579.6" "635.9" "576.6" "581.9" "509.6" "242.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8670958433918101160" "False" "High" "IsMasterProtein" "P26373" "Large ribosomal subunit protein eL13 OS=Homo sapiens OX=9606 GN=RPL13 PE=1 SV=4" "0.000" "False" "16.648" "27" "6" "7" "6" "211" "24.2" "11.65" "21.11" "6" "protein metabolism;other metabolic processes;developmental processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01294" "6137" "ENSG00000167526" "RPL13" "B4DLX3; F5H1S2; hsa:6137; P26373; Q3KQT8; Q567Q8; Q9BPX0" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.081" "0.914" "0.934" "1.151" "0.945" "1.114" "1.154" "0.862" "0.592" "758.5" "819.8" "693.0" "708.1" "873.4" "717.0" "845.1" "875.7" "653.6" "448.7" "" "" "" "" "" "" "" "" "" "" "682.0" "663.4" "626.9" "691.2" "720.7" "717.0" "632.8" "773.4" "584.8" "160.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8899762439150821704" "False" "High" "IsMasterProtein" "Q9H9Q4" "Non-homologous end-joining factor 1 OS=Homo sapiens OX=9606 GN=NHEJ1 PE=1 SV=1" "0.000" "False" "16.646" "21" "4" "5" "4" "299" "33.3" "5.97" "20.03" "4" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09302" "79840" "ENSG00000187736" "NHEJ1" "B8ZZA4; hsa:79840; Q4ZFW7; Q6IA64; Q96JS9; Q9H9Q4" "Non-homologous end joining; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ)" "3" "0" "0.983" "0.878" "0.993" "0.952" "1.136" "1.057" "1.116" "1.074" "0.913" "331.7" "326.0" "291.3" "329.3" "315.9" "376.9" "350.6" "370.1" "356.2" "302.8" "" "" "" "" "" "" "" "" "" "" "298.2" "263.8" "263.5" "321.5" "260.6" "376.9" "262.5" "326.9" "318.7" "108.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7008442538818735376" "False" "High" "IsMasterProtein" "Q8N4T8" "3-oxoacyl-[acyl-carrier-protein] reductase OS=Homo sapiens OX=9606 GN=CBR4 PE=1 SV=3" "0.000" "False" "16.640" "23" "4" "5" "4" "237" "25.3" "9.33" "21.51" "4" "cell organization and biogenesis;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf13561" "84869" "ENSG00000145439" "CBR4" "hsa:84869; Q8N4T8; Q8WTW8; Q96K93" "" "Fatty acyl-CoA biosynthesis" "1" "0" "1.094" "1.065" "1.168" "1.106" "1.086" "1.063" "1.099" "1.192" "0.801" "247.6" "270.8" "263.8" "289.0" "273.8" "268.8" "263.2" "272.1" "295.0" "198.4" "" "" "" "" "" "" "" "" "" "" "222.6" "219.1" "238.6" "282.2" "226.0" "268.8" "197.1" "240.3" "264.0" "70.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-708383096801431027" "False" "High" "IsMasterProtein" "Q9HD34" "LYR motif-containing protein 4 OS=Homo sapiens OX=9606 GN=LYRM4 PE=1 SV=1" "0.000" "False" "16.635" "42" "5" "7" "5" "91" "10.8" "10.73" "25.00" "5" "cell organization and biogenesis" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf05347" "57128" "ENSG00000214113" "LYRM4" "A8K543; hsa:57128; Q5XKP1; Q9HD34" "Iron-sulfur cluster biogenesis" "Mitochondrial iron-sulfur cluster biogenesis" "2" "0" "1.068" "1.028" "0.976" "1.062" "0.939" "1.019" "1.063" "0.957" "0.878" "679.6" "726.1" "698.4" "663.1" "721.8" "638.4" "692.2" "722.5" "650.5" "596.7" "" "" "" "" "" "" "" "" "" "" "611.0" "587.5" "631.7" "647.3" "595.7" "638.4" "518.3" "638.1" "582.1" "213.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6002449157154954042" "False" "High" "IsMasterProtein" "O60346" "PH domain leucine-rich repeat-containing protein phosphatase 1 OS=Homo sapiens OX=9606 GN=PHLPP1 PE=1 SV=3" "0.000" "False" "16.634" "4" "6" "6" "6" "1717" "184.6" "6.28" "17.31" "6" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00169, Pf00481, Pf00560, Pf13516, Pf13855" "23239" "ENSG00000081913" "PHLPP1" "A1A4F5; hsa:23239; O60346; Q641Q7; Q6P4C4; Q6PJI6; Q86TN6; Q96FK2; Q9NUY1" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway" "Negative regulation of the PI3K/AKT network" "3" "0" "1.197" "0.991" "1.000" "1.211" "1.126" "1.333" "1.260" "1.218" "1.347" "302.2" "361.7" "299.4" "302.1" "365.8" "340.1" "402.7" "380.7" "368.1" "407.0" "" "" "" "" "" "" "" "" "" "" "271.7" "292.7" "270.8" "294.9" "301.9" "340.1" "301.5" "336.3" "329.4" "145.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5032311727132364318" "False" "High" "IsMasterProtein" "Q8IVV7" "Glucose-induced degradation protein 4 homolog OS=Homo sapiens OX=9606 GN=GID4 PE=1 SV=1" "0.000" "False" "16.625" "15" "4" "5" "4" "300" "33.5" "9.16" "15.17" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf09783" "79018" "ENSG00000141034" "GID4" "hsa:79018; Q8IVV7; Q8TEB5; Q9BW50" "Ciliary landscape; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "2" "0" "1.007" "0.963" "0.976" "1.007" "0.863" "0.983" "0.911" "1.029" "0.924" "243.7" "245.5" "234.7" "237.8" "245.3" "210.2" "239.4" "221.9" "250.8" "225.3" "" "" "" "" "" "" "" "" "" "" "219.1" "198.6" "212.3" "232.2" "202.5" "210.2" "179.3" "196.0" "224.4" "80.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-788718536083084523" "False" "High" "IsMasterProtein" "Q9ULR0" "Pre-mRNA-splicing factor ISY1 homolog OS=Homo sapiens OX=9606 GN=ISY1 PE=1 SV=3" "0.000" "False" "16.622" "22" "6" "6" "6" "285" "33.0" "5.17" "21.99" "6" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf06246" "100534599; 57461" "ENSG00000240682" "ISY1" "hsa:100534599; hsa:57461; Q96IL2; Q9BT05; Q9ULR0" "" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "5" "0" "0.931" "1.104" "0.985" "1.044" "1.130" "1.014" "1.036" "1.153" "1.496" "324.6" "302.3" "358.4" "319.9" "338.8" "366.9" "329.1" "336.3" "374.2" "485.7" "" "" "" "" "" "" "" "" "" "" "291.9" "244.6" "324.2" "312.3" "279.6" "366.9" "246.4" "297.0" "334.9" "173.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4076214252454433299" "False" "High" "IsMasterProtein" "Q969G3" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Homo sapiens OX=9606 GN=SMARCE1 PE=1 SV=2" "0.000" "False" "16.615" "8" "3" "4" "3" "411" "46.6" "4.88" "16.25" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505" "6605" "ENSG00000073584" "SMARCE1" "B3KMC1; B4DFR4; C0IMW4; C0IMW5; C0IMW7; H7C3F6; hsa:6605; O43539; Q969G3" "Androgen receptor signaling pathway; Pathways affected in adenoid cystic carcinoma; Tumor suppressor activity of SMARCB1; Thermogenesis" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.944" "0.976" "0.924" "1.102" "0.986" "1.204" "0.879" "0.888" "3.365" "341.6" "322.5" "333.4" "315.7" "376.5" "336.8" "411.1" "300.3" "303.4" "1149.4" "" "" "" "" "" "" "" "" "" "" "307.1" "260.9" "301.6" "308.2" "310.7" "336.8" "307.8" "265.3" "271.5" "410.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7385395348648311511" "False" "High" "IsMasterProtein" "Q9HCP0" "Casein kinase I isoform gamma-1 OS=Homo sapiens OX=9606 GN=CSNK1G1 PE=1 SV=1" "0.000" "False" "16.598" "14" "6" "6" "2" "422" "48.5" "9.01" "19.44" "6" "cell-cell signaling;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf12605" "53944" "ENSG00000169118" "CSNK1G1" "hsa:53944; Q5JPH1; Q96AE9; Q9HCP0; Q9HCP1" "Wnt signaling pathway; Hedgehog signaling pathway" "" "2" "1" "0.955" "0.954" "0.935" "0.982" "0.936" "1.052" "0.943" "0.911" "0.784" "259.3" "247.6" "247.4" "242.5" "254.7" "242.7" "272.8" "244.5" "236.2" "203.3" "" "" "" "" "" "" "" "" "" "" "233.1" "200.3" "223.8" "236.7" "210.2" "242.7" "204.2" "216.0" "211.4" "72.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757061134285989517" "False" "High" "IsMasterProtein" "Q13586" "Stromal interaction molecule 1 OS=Homo sapiens OX=9606 GN=STIM1 PE=1 SV=3" "0.000" "False" "16.598" "10" "6" "6" "6" "685" "77.4" "6.67" "20.74" "6" "transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "cytoskeletal activity;other molecular function" "Pf07647, Pf16533" "6786" "ENSG00000167323" "STIM1" "E9PQJ4; hsa:6786; Q13586; Q8N382" "CAMKK2 pathway; Affected pathways in Duchenne muscular dystrophy" "Ion homeostasis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Elevation of cytosolic Ca2+ levels" "5" "0" "1.008" "1.061" "1.072" "1.059" "1.055" "1.160" "1.121" "1.050" "0.986" "715.8" "721.6" "759.5" "767.7" "757.8" "755.2" "830.0" "802.1" "751.8" "705.9" "" "" "" "" "" "" "" "" "" "" "643.6" "583.9" "687.0" "749.4" "625.3" "755.2" "621.5" "708.4" "672.7" "252.0" "6" "6" "6" "6" "6" "6" "6" "6" "6" "6" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "278925375883264414" "False" "High" "IsMasterProtein" "P23610" "40-kDa huntingtin-associated protein OS=Homo sapiens OX=9606 GN=F8A3 PE=1 SV=2" "0.000" "False" "16.592" "14" "4" "5" "4" "371" "39.1" "6.84" "24.76" "4" "transport;other biological processes" "nucleus;other cytoplasmic organelle" "" "" "474383; 474384; 8263" "ENSG00000277150; ENSG00000288709; ENSG00000288722" "F8A1; F8A2; F8A3" "hsa:474383; hsa:474384; hsa:8263; P23610; Q5HY66; Q8IXP3" "" "" "0" "0" "0.970" "1.005" "0.985" "0.839" "0.948" "0.844" "0.940" "0.952" "0.926" "315.6" "306.2" "317.2" "310.9" "264.7" "299.1" "266.4" "296.7" "300.3" "292.3" "" "" "" "" "" "" "" "" "" "" "283.7" "247.7" "286.9" "303.5" "218.5" "299.1" "199.5" "262.1" "268.7" "104.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-536665306058471520" "False" "High" "IsMasterProtein" "Q07020" "Large ribosomal subunit protein eL18 OS=Homo sapiens OX=9606 GN=RPL18 PE=1 SV=2" "0.000" "False" "16.579" "23" "4" "5" "4" "188" "21.6" "11.72" "19.17" "4" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf17135" "6141" "ENSG00000063177" "RPL18" "F8VWC5; hsa:6141; Q07020; Q8WTZ6" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.900" "0.879" "0.962" "1.022" "0.890" "0.968" "1.044" "0.875" "0.489" "444.0" "399.4" "390.4" "427.2" "453.9" "395.3" "430.0" "463.7" "388.5" "217.1" "" "" "" "" "" "" "" "" "" "" "399.2" "323.2" "353.2" "417.0" "374.5" "395.3" "321.9" "409.6" "347.7" "77.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7535964181824527260" "False" "High" "IsMasterProtein" "Q9H0E3" "Histone deacetylase complex subunit SAP130 OS=Homo sapiens OX=9606 GN=SAP130 PE=1 SV=1" "0.000" "False" "16.566" "6" "6" "7" "6" "1048" "110.3" "9.83" "18.07" "6" "other biological processes" "nucleus" "" "Pf16014" "79595" "ENSG00000136715" "SAP130" "B7ZLM3; C9K0X9; hsa:79595; Q4ZFV4; Q53T46; Q8WVW4; Q9H0E3; Q9H9G8" "" "NoRC negatively regulates rRNA expression; HATs acetylate histones" "2" "0" "0.994" "0.866" "1.007" "0.877" "0.841" "0.928" "0.893" "1.088" "1.427" "32.9" "32.8" "28.5" "33.2" "28.9" "27.7" "30.6" "29.4" "35.9" "47.0" "" "" "" "" "" "" "" "" "" "" "29.6" "26.5" "25.8" "32.4" "23.8" "27.7" "22.9" "26.0" "32.1" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4629432555354117988" "False" "High" "IsMasterProtein" "P78537" "Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Homo sapiens OX=9606 GN=BLOC1S1 PE=1 SV=2" "0.000" "False" "16.559" "25" "3" "4" "3" "153" "17.3" "9.33" "17.12" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "" "Pf06320" "2647" "ENSG00000135441" "BLOC1S1" "A1L4Q9; hsa:2647; P78537; Q6NZ45" "Alstrom syndrome" "Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "3" "0" "0.965" "0.978" "0.894" "1.017" "1.026" "0.980" "0.944" "0.960" "0.902" "501.8" "484.3" "491.0" "448.7" "510.4" "515.0" "491.7" "473.5" "481.8" "452.8" "" "" "" "" "" "" "" "" "" "" "451.2" "391.9" "444.1" "438.0" "421.2" "515.0" "368.2" "418.2" "431.1" "161.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7087591643624783243" "False" "High" "IsMasterProtein" "Q9H3C7" "Gametogenetin-binding protein 2 OS=Homo sapiens OX=9606 GN=GGNBP2 PE=1 SV=1" "0.000" "False" "16.559" "8" "4" "4" "4" "697" "79.0" "6.38" "16.67" "4" "developmental processes;other biological processes" "nucleus;other cell component" "" "" "79893" "ENSG00000275099; ENSG00000278311" "GGNBP2" "B2RPK7; hsa:79893; Q96T90; Q9GZR8; Q9H3C7; Q9H767" "17q12 copy number variation syndrome" "" "1" "0" "1.013" "1.092" "0.962" "1.115" "1.088" "1.071" "1.035" "1.077" "0.848" "199.3" "201.9" "217.7" "191.7" "222.2" "216.9" "213.5" "206.3" "214.6" "169.0" "" "" "" "" "" "" "" "" "" "" "179.2" "163.4" "196.9" "187.1" "183.4" "216.9" "159.8" "182.3" "192.0" "60.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289825156273590713" "False" "High" "IsMasterProtein" "Q5JTV8" "Torsin-1A-interacting protein 1 OS=Homo sapiens OX=9606 GN=TOR1AIP1 PE=1 SV=2" "0.000" "False" "16.559" "6" "3" "4" "3" "583" "66.2" "8.18" "17.63" "3" "cell organization and biogenesis;other biological processes" "other membranes;nucleus" "cytoskeletal activity;other molecular function" "Pf05609, Pf20443" "26092" "ENSG00000143337" "TOR1AIP1" "A0A0A0MSK5; A8K630; B0QZ57; hsa:26092; Q5JTV6; Q5JTV8; Q8IZ65; Q9H8Y6; Q9HAJ1; Q9NV52; Q9Y3X5" "Influence of laminopathies on Wnt signaling" "RHOD GTPase cycle; RHOF GTPase cycle" "3" "0" "0.996" "0.870" "0.926" "1.004" "0.977" "0.992" "0.956" "0.950" "0.751" "515.7" "513.4" "448.7" "477.5" "518.0" "503.6" "511.8" "493.2" "489.7" "387.3" "" "" "" "" "" "" "" "" "" "" "463.7" "415.5" "405.8" "466.1" "427.4" "503.6" "383.2" "435.6" "438.2" "138.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6202573485252222351" "False" "High" "IsMasterProtein" "Q9NZD2" "Glycolipid transfer protein OS=Homo sapiens OX=9606 GN=GLTP PE=1 SV=3" "0.000" "False" "16.539" "19" "4" "5" "4" "209" "23.8" "7.39" "19.92" "4" "cell organization and biogenesis;other metabolic processes;stress response;transport" "cytosol" "transporter activity;other molecular function" "Pf08718" "51228" "ENSG00000139433" "GLTP" "hsa:51228; Q53Z13; Q96J68; Q9NZD2" "" "Glycosphingolipid transport" "1" "0" "0.970" "1.029" "0.930" "1.038" "0.964" "1.017" "0.961" "1.020" "0.999" "506.2" "491.0" "520.7" "470.9" "525.2" "488.0" "514.8" "486.7" "516.4" "505.7" "" "" "" "" "" "" "" "" "" "" "455.2" "397.3" "471.0" "459.7" "433.4" "488.0" "385.5" "429.9" "462.1" "180.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2333660704476735765" "False" "High" "IsMasterProtein" "O15397" "Importin-8 OS=Homo sapiens OX=9606 GN=IPO8 PE=1 SV=2" "0.000" "False" "16.533" "4" "4" "8" "3" "1037" "119.9" "5.16" "26.06" "4" "transport;signal transduction" "cytosol;nucleus" "other molecular function" "Pf03810, Pf08506" "10526" "ENSG00000133704" "IPO8" "B7Z7M3; hsa:10526; O15397" "Autophagy in pancreatic ductal adenocarcinoma" "Transcriptional regulation by small RNAs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "394232053154577892" "False" "High" "IsMasterProtein" "Q92530" "Proteasome inhibitor PI31 subunit OS=Homo sapiens OX=9606 GN=PSMF1 PE=1 SV=2" "0.000" "False" "16.520" "25" "6" "8" "6" "271" "29.8" "5.74" "24.97" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf08577, Pf11566" "9491" "ENSG00000125818" "PSMF1" "A0AVQ9; D3DVW3; hsa:9491; Q92530; Q9H4I1" "" "Neddylation; KEAP1-NFE2L2 pathway; FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Activation of NF-kappaB in B cells; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; ER-Phagosome pathway; Cross-presentation of soluble exogenous antigens (endosomes); SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Vpu mediated degradation of CD4; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Regulation of activated PAK-2p34 by proteasome mediated degradation; Separation of Sister Chromatids; Autodegradation of the E3 ubiquitin ligase COP1; Regulation of ornithine decarboxylase (ODC); ABC-family proteins mediated transport; AUF1 (hnRNP D0) binds and destabilizes mRNA; Asymmetric localization of PCP proteins; Degradation of AXIN; Degradation of DVL; Hedgehog ligand biogenesis; Hh mutants are degraded by ERAD; Dectin-1 mediated noncanonical NF-kB signaling; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; NIK-->noncanonical NF-kB signaling; Defective CFTR causes cystic fibrosis; MAPK6/MAPK4 signaling; UCH proteinases; Ub-specific processing proteases; Orc1 removal from chromatin; CDK-mediated phosphorylation and removal of Cdc6; G2/M Checkpoints; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; Ubiquitin-dependent degradation of Cyclin D; The role of GTSE1 in G2/M progression after G2 checkpoint; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of expression of SLITs and ROBOs; Interleukin-1 signaling; Somitogenesis; Autodegradation of Cdh1 by Cdh1:APC/C; SCF(Skp2)-mediated degradation of p27/p21; Assembly of the pre-replicative complex; Regulation of RUNX3 expression and activity; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2" "59" "0" "1.065" "0.977" "0.970" "1.050" "0.979" "1.044" "1.069" "1.042" "0.723" "463.0" "493.3" "452.4" "449.0" "486.0" "453.2" "483.3" "495.1" "482.6" "334.8" "" "" "" "" "" "" "" "" "" "" "416.3" "399.2" "409.2" "438.3" "401.1" "453.2" "361.9" "437.3" "431.8" "119.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502285001895834817" "False" "High" "IsMasterProtein" "Q99638" "Cell cycle checkpoint control protein RAD9A OS=Homo sapiens OX=9606 GN=RAD9A PE=1 SV=1" "0.000" "False" "16.513" "16" "6" "6" "6" "391" "42.5" "5.66" "20.31" "6" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04139" "5883" "ENSG00000172613" "RAD9A" "B2RCZ8; hsa:5883; Q6FI29; Q96C41; Q99638" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; ATM signaling pathway; ATR signaling; DNA IR-double strand breaks and cellular response via ATM; NF1 copy number variation syndrome ; DNA damage response" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Activation of ATR in response to replication stress" "14" "0" "1.017" "0.997" "0.983" "1.141" "1.004" "1.188" "1.114" "1.033" "0.862" "336.1" "341.7" "334.9" "330.4" "383.3" "337.4" "399.1" "374.5" "347.3" "289.6" "" "" "" "" "" "" "" "" "" "" "302.1" "276.5" "303.0" "322.6" "316.3" "337.4" "298.8" "330.8" "310.7" "103.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7240944493038279722" "False" "High" "IsMasterProtein" "Q9Y676" "Small ribosomal subunit protein mS40 OS=Homo sapiens OX=9606 GN=MRPS18B PE=1 SV=1" "0.000" "False" "16.506" "21" "4" "4" "4" "258" "29.4" "9.38" "17.19" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01084" "28973" "ENSG00000203624; ENSG00000204568; ENSG00000223775; ENSG00000226111; ENSG00000227420; ENSG00000229861; ENSG00000233813" "MRPS18B" "A6NDQ0; hsa:28973; Q659G4; Q9BS27; Q9Y676" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.932" "0.875" "0.938" "0.832" "0.862" "0.925" "0.880" "0.886" "1.291" "510.5" "475.7" "446.6" "478.8" "424.8" "439.8" "472.3" "449.0" "452.4" "658.9" "" "" "" "" "" "" "" "" "" "" "459.0" "384.9" "404.0" "467.3" "350.6" "439.8" "353.7" "396.6" "404.8" "235.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2427980612750648457" "False" "High" "IsMasterProtein" "P21359" "Neurofibromin OS=Homo sapiens OX=9606 GN=NF1 PE=1 SV=2" "0.000" "False" "16.498" "3" "7" "8" "7" "2839" "319.2" "7.39" "11.92" "7" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00616, Pf13716" "4763" "ENSG00000196712" "NF1" "hsa:4763; O00662; P21359; Q14284; Q14930; Q14931; Q9UMK3" "Pilocytic astrocytoma; Glioblastoma signaling pathways; Aryl hydrocarbon receptor pathway; MECP2 and associated Rett syndrome; MAPK signaling pathway; Ras signaling; Transcription co-factors SKI and SKIL protein partners; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Melanoma; EGFR tyrosine kinase inhibitor resistance; NF1 copy number variation syndrome" "Regulation of RAS by GAPs; RAS signaling downstream of NF1 loss-of-function variants" "14" "0" "1.099" "0.935" "0.760" "1.051" "0.791" "1.059" "0.937" "0.995" "0.705" "458.8" "504.3" "428.9" "348.8" "482.0" "362.7" "485.7" "430.0" "456.6" "323.5" "" "" "" "" "" "" "" "" "" "" "412.5" "408.1" "388.0" "340.5" "397.8" "362.7" "363.7" "379.8" "408.6" "115.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2300421444410781361" "False" "High" "IsMasterProtein" "Q9BRP1" "Programmed cell death protein 2-like OS=Homo sapiens OX=9606 GN=PDCD2L PE=1 SV=1" "0.000" "False" "16.491" "18" "5" "7" "5" "358" "39.4" "4.86" "22.47" "5" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf04194" "84306" "ENSG00000126249" "PDCD2L" "hsa:84306; Q9BRP1" "" "" "0" "0" "0.954" "0.995" "1.033" "1.034" "1.001" "1.006" "1.017" "1.044" "0.853" "605.4" "577.6" "602.1" "625.1" "625.7" "605.7" "609.0" "615.6" "632.3" "516.5" "" "" "" "" "" "" "" "" "" "" "544.3" "467.4" "544.6" "610.2" "516.4" "605.7" "456.0" "543.8" "565.8" "184.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5475559016249233817" "False" "High" "IsMasterProtein" "Q9NVT9" "Armadillo repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=ARMC1 PE=1 SV=1" "0.000" "False" "16.481" "19" "5" "5" "5" "282" "31.3" "5.74" "18.85" "5" "cell organization and biogenesis" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf00514" "55156" "ENSG00000104442" "ARMC1" "B4E2W7; hsa:55156; Q9H018; Q9H820; Q9NVT9" "" "" "0" "0" "1.047" "1.108" "1.026" "1.219" "0.991" "1.108" "1.089" "1.009" "1.224" "315.3" "330.2" "349.3" "323.5" "384.2" "312.4" "349.2" "343.3" "318.1" "385.8" "" "" "" "" "" "" "" "" "" "" "283.5" "267.2" "315.9" "315.8" "317.0" "312.4" "261.5" "303.3" "284.6" "137.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-313217822058437387" "False" "High" "IsMasterProtein" "P55789" "FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens OX=9606 GN=GFER PE=1 SV=2" "0.000" "False" "16.467" "31" "5" "5" "5" "205" "23.4" "7.62" "23.05" "5" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion" "signal transduction activity or receptor binding;other molecular function" "Pf04777" "2671" "ENSG00000127554; ENSG00000291944" "GFER" "hsa:2671; P55789; Q53YM6; Q8TAH6; Q9H290; Q9UK40" "" "Mitochondrial protein import" "1" "0" "0.931" "0.979" "0.931" "1.037" "1.029" "0.950" "1.020" "1.001" "0.776" "333.1" "310.2" "326.1" "310.3" "345.3" "342.8" "316.4" "339.8" "333.6" "258.4" "" "" "" "" "" "" "" "" "" "" "299.5" "251.0" "295.0" "302.9" "285.0" "342.8" "236.9" "300.1" "298.5" "92.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3728877322360888626" "False" "High" "IsMasterProtein" "P62854" "Small ribosomal subunit protein eS26 OS=Homo sapiens OX=9606 GN=RPS26 PE=1 SV=3" "0.000" "False" "16.450" "31" "3" "5" "3" "115" "13.0" "11.00" "20.69" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01283" "6231" "ENSG00000197728" "RPS26" "hsa:6231; P02383; P62854; P70394; Q06722; Q3MHD8; Q6IRY4" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Peptide chain elongation; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.948" "0.998" "1.008" "1.068" "1.226" "1.014" "0.964" "1.105" "1.145" "347.0" "329.1" "346.3" "349.7" "370.8" "425.6" "352.1" "334.5" "383.6" "397.2" "" "" "" "" "" "" "" "" "" "" "312.0" "266.3" "313.3" "341.4" "306.0" "425.6" "263.6" "295.4" "343.2" "141.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2021642276248058836" "False" "High" "IsMasterProtein" "Q8TD30" "Alanine aminotransferase 2 OS=Homo sapiens OX=9606 GN=GPT2 PE=1 SV=1" "0.000" "False" "16.436" "12" "6" "6" "6" "523" "57.9" "7.71" "20.95" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00155" "84706" "ENSG00000166123" "GPT2" "hsa:84706; Q8N9E2; Q8TD30" "Amino acid metabolism; Amino acid metabolism pathway excerpt: histidine catabolism extension" "" "2" "0" "1.018" "1.019" "0.984" "0.971" "0.993" "0.923" "0.990" "0.997" "1.334" "356.5" "363.1" "363.2" "351.0" "346.4" "354.1" "328.9" "353.0" "355.4" "475.5" "" "" "" "" "" "" "" "" "" "" "320.6" "293.8" "328.5" "342.6" "285.8" "354.1" "246.3" "311.8" "318.0" "169.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-776165374606149247" "False" "High" "IsMasterProtein" "Q99547" "M-phase phosphoprotein 6 OS=Homo sapiens OX=9606 GN=MPHOSPH6 PE=1 SV=2" "0.000" "False" "16.424" "38" "5" "7" "5" "160" "19.0" "5.20" "24.18" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf10175" "10200" "ENSG00000135698" "MPHOSPH6" "B2RAF0; hsa:10200; Q99547" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "1.123" "0.940" "0.898" "1.004" "1.105" "1.005" "0.977" "1.033" "1.495" "493.9" "554.8" "464.0" "443.3" "495.7" "545.8" "496.4" "482.4" "510.4" "738.4" "" "" "" "" "" "" "" "" "" "" "444.1" "448.9" "419.7" "432.7" "409.1" "545.8" "371.7" "426.1" "456.7" "263.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4744508132045603899" "False" "High" "IsMasterProtein" "Q9BZG8" "2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 OS=Homo sapiens OX=9606 GN=DPH1 PE=1 SV=3" "0.000" "False" "16.422" "11" "5" "8" "5" "438" "48.1" "7.84" "17.13" "5" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01866" "1801" "ENSG00000108963" "DPH1" "A0A6Q8JGF9; D3DTI3; hsa:1801; Q16439; Q4VBA2; Q9BTW7; Q9BZG8; Q9UCY0" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.127" "1.030" "0.999" "1.016" "0.999" "1.052" "1.037" "1.009" "0.903" "187.2" "211.0" "192.8" "187.0" "190.2" "186.9" "197.0" "194.0" "188.8" "169.1" "" "" "" "" "" "" "" "" "" "" "168.3" "170.7" "174.4" "182.5" "157.0" "186.9" "147.5" "171.4" "169.0" "60.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5357414389544456501" "False" "High" "IsMasterProtein" "P55212" "Caspase-6 OS=Homo sapiens OX=9606 GN=CASP6 PE=1 SV=2" "0.000" "False" "16.373" "13" "4" "5" "3" "293" "33.3" "6.93" "14.83" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656" "839" "ENSG00000138794" "CASP6" "hsa:839; P55212; Q9BQE7" "Parkinson's disease pathway; Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Acute viral myocarditis" "TP53 Regulates Transcription of Caspase Activators and Caspases; Caspase-mediated cleavage of cytoskeletal proteins; Breakdown of the nuclear lamina" "10" "0" "1.057" "1.121" "1.028" "0.988" "1.010" "1.041" "0.952" "1.052" "0.868" "307.3" "324.7" "344.5" "315.9" "303.5" "310.2" "319.9" "292.5" "323.4" "266.7" "" "" "" "" "" "" "" "" "" "" "276.3" "262.7" "311.6" "308.4" "250.4" "310.2" "239.5" "258.4" "289.4" "95.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7472508916157269106" "False" "High" "IsMasterProtein" "Q9H9P8" "L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=L2HGDH PE=1 SV=3" "0.000" "False" "16.373" "12" "5" "5" "5" "463" "50.3" "8.15" "15.08" "5" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01266" "79944" "ENSG00000087299" "L2HGDH" "hsa:79944; Q9BRR1; Q9H9P8" "Cerebral organic acidurias, including diseases" "Interconversion of 2-oxoglutarate and 2-hydroxyglutarate" "2" "0" "0.969" "0.938" "0.910" "0.871" "0.945" "0.820" "0.893" "1.013" "0.863" "536.3" "519.4" "503.0" "488.0" "467.0" "507.0" "440.0" "478.8" "543.4" "462.6" "" "" "" "" "" "" "" "" "" "" "482.2" "420.3" "455.0" "476.4" "385.3" "507.0" "329.5" "422.9" "486.2" "165.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1443049690155721947" "False" "High" "IsMasterProtein" "Q9H0E2" "Toll-interacting protein OS=Homo sapiens OX=9606 GN=TOLLIP PE=1 SV=1" "0.000" "False" "16.369" "16" "4" "5" "4" "274" "30.3" "5.97" "19.14" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf02845" "54472" "ENSG00000078902; ENSG00000291426" "TOLLIP" "B3KXC6; hsa:54472; Q9H0E2; Q9H9E6; Q9UJ69" "IL-1 signaling pathway; Interleukin-1 (IL-1) structural pathway; Toll-like receptor signaling related to MyD88; Signal transduction through IL1R; Toll-like receptor signaling pathway" "Neutrophil degranulation; Interleukin-1 signaling" "7" "0" "0.985" "0.887" "0.976" "1.095" "0.935" "0.946" "1.005" "0.982" "0.899" "119.9" "118.1" "106.3" "117.0" "131.2" "112.1" "113.4" "120.5" "117.7" "107.8" "" "" "" "" "" "" "" "" "" "" "107.8" "95.6" "96.2" "114.2" "108.3" "112.1" "84.9" "106.4" "105.3" "38.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6888861531159930886" "False" "High" "IsMasterProtein" "Q9H832" "Ubiquitin-conjugating enzyme E2 Z OS=Homo sapiens OX=9606 GN=UBE2Z PE=1 SV=2" "0.000" "False" "16.368" "17" "6" "9" "6" "354" "38.2" "5.62" "24.43" "6" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00179" "65264" "ENSG00000159202" "UBE2Z" "A6N8M6; A6NC60; hsa:65264; Q7L354; Q8TCM4; Q9H832; Q9H893" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "0.991" "1.011" "1.032" "1.033" "0.994" "0.966" "1.081" "1.080" "0.957" "741.6" "735.2" "749.9" "765.2" "766.1" "736.7" "716.4" "801.9" "801.2" "710.0" "" "" "" "" "" "" "" "" "" "" "666.7" "594.9" "678.3" "746.9" "632.2" "736.7" "536.4" "708.3" "716.9" "253.5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3244624518097785869" "False" "High" "IsMasterProtein" "Q676U5" "Autophagy-related protein 16-1 OS=Homo sapiens OX=9606 GN=ATG16L1 PE=1 SV=2" "0.000" "False" "16.348" "9" "6" "8" "6" "607" "68.2" "6.64" "24.93" "6" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf08614" "55054" "ENSG00000085978; ENSG00000281089" "ATG16L1" "A3EXK9; A3EXL0; B6ZDH0; hsa:55054; Q676U5; Q6IPN1; Q6UXW4; Q6ZVZ5; Q8NCY2; Q96JV5; Q9H619" "Nanoparticle triggered autophagic cell death; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; LDLRAD4 and what we know about it; Autophagy; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "1.086" "1.086" "0.987" "1.034" "1.063" "0.950" "1.032" "1.015" "0.874" "252.9" "274.5" "274.7" "249.5" "261.4" "268.8" "240.1" "261.1" "256.7" "220.9" "" "" "" "" "" "" "" "" "" "" "227.4" "222.1" "248.5" "243.6" "215.7" "268.8" "179.8" "230.6" "229.7" "78.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4471823552801457794" "False" "High" "IsMasterProtein" "Q9GZN1" "Actin-related protein 6 OS=Homo sapiens OX=9606 GN=ACTR6 PE=1 SV=1" "0.000" "False" "16.328" "13" "4" "7" "4" "396" "45.8" "5.03" "17.31" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00022" "64431" "ENSG00000075089" "ACTR6" "B3KW37; B4DLG9; hsa:64431; Q53GH2; Q9BY39; Q9GZN1; Q9H8H6" "" "" "0" "0" "1.110" "1.108" "0.970" "1.094" "1.038" "1.029" "1.028" "1.006" "1.111" "289.9" "321.8" "321.1" "281.1" "317.0" "300.9" "298.2" "298.1" "291.5" "321.9" "" "" "" "" "" "" "" "" "" "" "260.6" "260.4" "290.4" "274.4" "261.6" "300.9" "223.3" "263.3" "260.8" "114.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "558828740565352174" "False" "High" "IsMasterProtein" "Q2VPK5" "Cytoplasmic tRNA 2-thiolation protein 2 OS=Homo sapiens OX=9606 GN=CTU2 PE=1 SV=1" "0.000" "False" "16.300" "14" "6" "7" "6" "515" "56.1" "6.32" "12.97" "6" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf10288" "348180" "ENSG00000174177" "CTU2" "B2RXK0; hsa:348180; Q0P511; Q2VPK5; Q66K78; Q6P4C8; Q86SV4" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.023" "1.037" "0.965" "0.969" "0.954" "0.994" "1.024" "0.925" "1.343" "217.9" "222.9" "225.9" "210.4" "211.2" "207.8" "216.7" "223.1" "201.5" "292.7" "" "" "" "" "" "" "" "" "" "" "196.0" "180.4" "204.4" "205.4" "174.3" "207.8" "162.2" "197.1" "180.3" "104.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7573385717766537595" "False" "High" "IsMasterProtein" "Q9GZT9" "Egl nine homolog 1 OS=Homo sapiens OX=9606 GN=EGLN1 PE=1 SV=1" "0.000" "False" "16.288" "13" "5" "5" "5" "426" "46.0" "8.53" "13.81" "5" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01753, Pf13640" "54583" "ENSG00000135766" "EGLN1" "hsa:54583; Q8N3M8; Q9BZS8; Q9BZT0; Q9GZT9" "Photodynamic therapy-induced HIF-1 survival signaling; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Markers of kidney cell lineage" "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha" "5" "0" "1.108" "1.073" "1.029" "1.138" "1.013" "1.064" "1.172" "1.095" "1.617" "686.8" "761.2" "736.8" "707.0" "781.5" "695.8" "730.8" "804.8" "751.8" "1110.4" "" "" "" "" "" "" "" "" "" "" "617.5" "616.0" "666.5" "690.1" "644.9" "695.8" "547.2" "710.9" "672.7" "396.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "504093738677667823" "False" "High" "IsMasterProtein" "O14867" "Transcription regulator protein BACH1 OS=Homo sapiens OX=9606 GN=BACH1 PE=1 SV=2" "0.000" "False" "16.272" "7" "4" "6" "4" "736" "81.9" "5.05" "20.88" "4" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf03131" "571" "ENSG00000156273" "BACH1" "hsa:571; O14867; O43285; Q6ICU0" "Integrated cancer pathway; Ferroptosis" "Heme signaling; Regulation of HMOX1 expression and activity; Regulation of BACH1 activity; NFE2L2 regulating anti-oxidant/detoxification enzymes" "6" "0" "1.033" "1.239" "0.988" "1.142" "1.049" "1.117" "1.065" "1.246" "1.224" "211.1" "218.1" "261.6" "208.5" "241.1" "221.5" "235.7" "224.9" "263.0" "258.3" "" "" "" "" "" "" "" "" "" "" "189.8" "176.5" "236.6" "203.5" "198.9" "221.5" "176.5" "198.6" "235.3" "92.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-375580382225270930" "False" "High" "IsMasterProtein" "Q96LI5" "CCR4-NOT transcription complex subunit 6-like OS=Homo sapiens OX=9606 GN=CNOT6L PE=1 SV=2" "0.000" "False" "16.267" "8" "4" "5" "4" "555" "63.0" "6.74" "17.05" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03372, Pf13855" "246175" "ENSG00000138767" "CNOT6L" "hsa:246175; Q96LI5; Q9UF92" "Ciliary landscape" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "4" "0" "1.147" "1.000" "0.989" "1.065" "0.955" "0.987" "0.929" "1.031" "1.251" "97.5" "111.9" "97.6" "96.5" "103.9" "93.2" "96.3" "90.7" "100.5" "122.0" "" "" "" "" "" "" "" "" "" "" "87.7" "90.6" "88.3" "94.2" "85.8" "93.2" "72.1" "80.1" "90.0" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4493911830020970266" "False" "High" "IsMasterProtein" "Q9BQE9" "B-cell CLL/lymphoma 7 protein family member B OS=Homo sapiens OX=9606 GN=BCL7B PE=1 SV=1" "0.000" "False" "16.261" "24" "5" "5" "2" "202" "22.2" "4.75" "17.49" "5" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf04714" "9275" "ENSG00000106635" "BCL7B" "A8K226; C9JWD3; D3DXF0; hsa:9275; O43769; Q13845; Q6ZW75; Q9BQE9" "7q11.23 copy number variation syndrome" "" "1" "0" "0.864" "0.974" "0.923" "0.932" "0.994" "0.951" "0.946" "1.017" "1.457" "194.3" "167.8" "189.2" "179.4" "181.2" "193.2" "184.9" "183.8" "197.6" "283.0" "" "" "" "" "" "" "" "" "" "" "174.7" "135.8" "171.1" "175.1" "149.5" "193.2" "138.4" "162.3" "176.8" "101.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7985947186271226833" "False" "High" "IsMasterProtein" "Q9UPW0" "Forkhead box protein J3 OS=Homo sapiens OX=9606 GN=FOXJ3 PE=1 SV=2" "0.000" "False" "16.258" "11" "6" "6" "6" "622" "68.9" "7.09" "16.63" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00250" "22887" "ENSG00000198815" "FOXJ3" "A7MBL7; A7MD18; D3DPW2; hsa:22887; Q9NSS7; Q9UPW0" "" "" "0" "0" "0.954" "0.994" "0.929" "1.060" "1.022" "1.016" "1.005" "1.029" "1.259" "432.4" "412.6" "430.0" "401.6" "458.4" "441.9" "439.5" "434.4" "444.9" "544.5" "" "" "" "" "" "" "" "" "" "" "388.8" "333.8" "389.0" "392.0" "378.3" "441.9" "329.1" "383.7" "398.1" "194.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2544930509745837934" "False" "High" "IsMasterProtein" "P81877" "Single-stranded DNA-binding protein 2 OS=Homo sapiens OX=9606 GN=SSBP2 PE=1 SV=2" "0.000" "False" "16.247" "17" "4" "6" "3" "361" "37.8" "6.64" "18.29" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04503" "23635" "ENSG00000145687" "SSBP2" "B2R5W1; B7Z1J2; B7Z2L9; B7Z665; D6RH18; E9PB74; E9PDA8; hsa:23635; P81877; Q8N2Q2; Q9BWW6; Q9Y4T7" "" "" "0" "1" "0.986" "0.879" "0.919" "0.990" "1.037" "1.153" "1.016" "0.952" "0.776" "284.6" "280.5" "250.0" "261.6" "281.8" "295.1" "328.0" "289.2" "270.9" "220.7" "" "" "" "" "" "" "" "" "" "" "255.9" "227.0" "226.2" "255.4" "232.5" "295.1" "245.6" "255.4" "242.4" "78.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3451981213719268513" "False" "High" "IsMasterProtein" "Q9Y5Y6" "Suppressor of tumorigenicity 14 protein OS=Homo sapiens OX=9606 GN=ST14 PE=1 SV=2" "0.000" "False" "16.238" "6" "4" "5" "4" "855" "94.7" "6.55" "17.08" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00057, Pf00089, Pf00431, Pf01390" "6768" "ENSG00000149418" "ST14" "hsa:6768; Q9BS01; Q9H3S0; Q9HB36; Q9HCA3; Q9Y5Y6" "" "Formation of the cornified envelope" "1" "0" "1.129" "0.957" "0.976" "1.203" "0.863" "1.178" "1.001" "1.103" "0.788" "188.5" "212.9" "180.4" "183.9" "226.7" "162.7" "222.1" "188.7" "207.9" "148.5" "" "" "" "" "" "" "" "" "" "" "169.5" "172.2" "163.2" "179.5" "187.1" "162.7" "166.3" "166.6" "186.0" "53.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8347450561102329946" "False" "High" "IsMasterProtein" "Q96BZ4" "5'-3' exonuclease PLD4 OS=Homo sapiens OX=9606 GN=PLD4 PE=1 SV=2" "0.000" "False" "16.230" "9" "4" "6" "4" "506" "55.6" "8.35" "17.94" "4" "DNA metabolism;stress response;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13918" "122618" "ENSG00000166428" "PLD4" "hsa:122618; Q6UWD2; Q96BZ4" "" "Role of phospholipids in phagocytosis; Synthesis of PG; Synthesis of IP3 and IP4 in the cytosol" "3" "0" "1.071" "1.065" "1.025" "1.176" "1.117" "1.123" "1.001" "1.142" "0.825" "202.6" "217.0" "215.6" "207.6" "238.3" "226.3" "227.6" "202.7" "231.3" "167.2" "" "" "" "" "" "" "" "" "" "" "182.1" "175.6" "195.1" "202.6" "196.6" "226.3" "170.4" "179.0" "207.0" "59.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265190665490175279" "False" "High" "IsMasterProtein" "Q6IQ22" "Ras-related protein Rab-12 OS=Homo sapiens OX=9606 GN=RAB12 PE=1 SV=3" "0.000" "False" "16.229" "17" "3" "12" "2" "244" "27.2" "8.41" "34.15" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00071" "201475" "" "RAB12" "A6NEF5; hsa:201475; Q4KMQ3; Q6IQ22" "" "RAB GEFs exchange GTP for GDP on RABs; RAB geranylgeranylation" "2" "0" "0.985" "1.111" "0.903" "1.005" "1.130" "0.952" "1.069" "0.959" "0.917" "50.5" "49.7" "56.1" "45.6" "50.7" "57.1" "48.1" "54.0" "48.4" "46.3" "" "" "" "" "" "" "" "" "" "" "45.4" "40.2" "50.7" "44.5" "41.9" "57.1" "36.0" "47.7" "43.3" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3935713179938084537" "False" "High" "IsMasterProtein" "Q96HP4" "Oxidoreductase NAD-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXNAD1 PE=1 SV=1" "0.000" "False" "16.220" "13" "4" "5" "4" "312" "34.8" "8.37" "17.08" "4" "" "" "other molecular function" "Pf00175" "92106" "ENSG00000154814" "OXNAD1" "hsa:92106; Q2HYC7; Q59FA4; Q96HP4" "" "" "0" "0" "1.087" "1.135" "0.990" "1.037" "1.053" "1.071" "1.011" "1.104" "0.929" "342.6" "372.5" "388.7" "339.2" "355.2" "360.8" "367.0" "346.3" "378.3" "318.2" "" "" "" "" "" "" "" "" "" "" "308.0" "301.4" "351.6" "331.1" "293.1" "360.8" "274.8" "305.9" "338.5" "113.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721253402515192355" "False" "High" "IsMasterProtein" "O95544" "NAD kinase OS=Homo sapiens OX=9606 GN=NADK PE=1 SV=1" "0.000" "False" "16.217" "13" "4" "5" "4" "446" "49.2" "6.47" "17.61" "4" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf01513, Pf20143" "65220" "ENSG00000008130" "NADK" "A6NNN3; A8K296; B7Z434; F5GXR5; hsa:65220; O95544; Q5QPS4; Q9H2P2; Q9H931" "NAD+ metabolism; 1p36 copy number variation syndrome" "Nicotinate metabolism" "3" "0" "1.001" "1.044" "0.890" "0.952" "1.109" "0.962" "0.979" "0.957" "0.766" "437.2" "437.6" "456.5" "389.2" "416.1" "485.1" "420.8" "428.0" "418.4" "334.8" "" "" "" "" "" "" "" "" "" "" "393.1" "354.1" "412.9" "379.9" "343.4" "485.1" "315.1" "378.0" "374.4" "119.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "841386405994122390" "False" "High" "IsMasterProtein" "Q92785" "Zinc finger protein ubi-d4 OS=Homo sapiens OX=9606 GN=DPF2 PE=1 SV=2" "0.000" "False" "16.196" "15" "5" "5" "5" "391" "44.1" "6.33" "17.79" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00628, Pf14051" "5977" "ENSG00000133884" "DPF2" "A8K7C9; B4DT58; hsa:5977; Q92785" "Tumor suppressor activity of SMARCB1" "" "1" "0" "0.811" "0.903" "1.012" "0.951" "0.864" "0.921" "0.864" "0.874" "2.979" "356.0" "288.7" "321.4" "360.3" "338.7" "307.6" "327.9" "307.6" "311.1" "1060.6" "" "" "" "" "" "" "" "" "" "" "320.1" "233.6" "290.7" "351.7" "279.5" "307.6" "245.5" "271.7" "278.4" "378.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7993967056221403717" "False" "High" "IsMasterProtein" "Q9BU02" "Thiamine-triphosphatase OS=Homo sapiens OX=9606 GN=THTPA PE=1 SV=3" "0.000" "False" "16.190" "25" "5" "6" "5" "230" "25.6" "4.82" "22.15" "5" "other metabolic processes" "cytosol" "other molecular function" "Pf01928" "79178" "ENSG00000259431" "THTPA" "D3DS50; G3V4J3; hsa:79178; Q9BU02" "" "Vitamin B1 (thiamin) metabolism" "1" "0" "1.058" "1.054" "0.946" "1.012" "1.036" "0.960" "1.019" "1.000" "1.091" "682.8" "722.1" "719.7" "645.9" "691.3" "707.3" "655.8" "696.0" "682.7" "745.2" "" "" "" "" "" "" "" "" "" "" "613.9" "584.3" "651.0" "630.5" "570.5" "707.3" "491.0" "614.8" "610.9" "266.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-994823259514569156" "False" "High" "IsMasterProtein" "Q96I59" "Asparaginyl-tRNA synthetase OS=Homo sapiens OX=9606 GN=NARS2 PE=1 SV=3" "0.000" "False" "16.171" "10" "5" "5" "5" "477" "54.1" "7.24" "18.19" "5" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00152, Pf01336" "79731" "ENSG00000137513" "NARS2" "G3V178; hsa:79731; Q96I59" "Ectoderm differentiation" "Mitochondrial tRNA aminoacylation" "2" "0" "1.006" "0.976" "0.927" "0.996" "0.829" "0.936" "0.970" "0.920" "0.926" "602.6" "606.5" "588.0" "558.6" "600.3" "499.5" "564.2" "584.3" "554.2" "558.1" "" "" "" "" "" "" "" "" "" "" "541.8" "490.7" "531.8" "545.3" "495.3" "499.5" "422.4" "516.1" "495.9" "199.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8976168612742678464" "False" "High" "IsMasterProtein" "Q13243" "Serine/arginine-rich splicing factor 5 OS=Homo sapiens OX=9606 GN=SRSF5 PE=1 SV=1" "0.000" "False" "16.171" "17" "4" "7" "3" "272" "31.2" "11.59" "24.29" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "" "Pf00076" "6430" "ENSG00000100650" "SRSF5" "hsa:6430; O14797; Q13243; Q16662; Q49AD6; Q6FGE0" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "0" "0.944" "0.910" "0.970" "0.913" "0.906" "0.888" "0.919" "0.928" "0.887" "583.9" "551.1" "531.5" "566.5" "533.2" "528.9" "518.7" "536.4" "541.9" "518.1" "" "" "" "" "" "" "" "" "" "" "525.0" "445.9" "480.8" "552.9" "440.0" "528.9" "388.4" "473.8" "484.9" "184.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4572306403840384650" "False" "High" "IsMasterProtein" "O75208" "Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Homo sapiens OX=9606 GN=COQ9 PE=1 SV=1" "0.000" "False" "16.162" "19" "5" "10" "5" "318" "35.5" "5.94" "30.42" "5" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf08511, Pf21392" "57017" "ENSG00000088682" "COQ9" "A8K3L2; hsa:57017; O75208; Q7L5V7; Q7Z5T6; Q8NBL4; Q9NTJ2; Q9P056" "" "Ubiquinol biosynthesis" "1" "0" "1.003" "1.021" "1.086" "1.157" "1.182" "0.883" "0.987" "1.174" "0.999" "96.1" "96.4" "98.1" "104.4" "111.2" "113.6" "84.9" "94.9" "112.9" "96.0" "" "" "" "" "" "" "" "" "" "" "86.4" "78.0" "88.8" "101.9" "91.8" "113.6" "63.6" "83.8" "101.0" "34.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8251896987743937176" "False" "High" "IsMasterProtein" "P53680" "AP-2 complex subunit sigma OS=Homo sapiens OX=9606 GN=AP2S1 PE=1 SV=2" "0.000" "False" "16.156" "37" "5" "8" "5" "142" "17.0" "6.18" "23.98" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1175" "ENSG00000042753" "AP2S1" "B2R4Z4; hsa:1175; O75977; P53680; Q6PK67" "Synaptic vesicle pathway; VEGFA-VEGFR2 signaling; GABA receptor signaling; EGF/EGFR signaling pathway; Fragile X syndrome" "MHC class II antigen presentation; Cargo recognition for clathrin-mediated endocytosis; Potential therapeutics for SARS; Recycling pathway of L1; WNT5A-dependent internalization of FZD4; EPH-ephrin mediated repulsion of cells; LDL clearance; Nef Mediated CD4 Down-regulation; Retrograde neurotrophin signalling; Nef Mediated CD8 Down-regulation; WNT5A-dependent internalization of FZD2, FZD5 and ROR2; VLDLR internalisation and degradation" "18" "0" "1.029" "1.005" "0.899" "1.022" "0.908" "0.990" "0.948" "1.002" "0.906" "462.2" "475.5" "464.6" "415.6" "472.2" "419.6" "457.7" "438.3" "463.2" "418.7" "" "" "" "" "" "" "" "" "" "" "415.6" "384.7" "420.2" "405.7" "389.6" "419.6" "342.7" "387.2" "414.4" "149.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378984088295691653" "False" "High" "IsMasterProtein" "P49023" "Paxillin OS=Homo sapiens OX=9606 GN=PXN PE=1 SV=3" "0.000" "False" "16.153" "9" "5" "6" "5" "591" "64.5" "6.19" "15.62" "5" "cell adhesion;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00412, Pf03535" "5829" "ENSG00000089159" "PXN" "B2RAI3; B7ZMB4; hsa:5829; O14970; O14971; O60360; P49023; Q5HYA4" "Integrin-mediated cell adhesion; Prolactin signaling pathway; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement; Gastrin signaling pathway; 3q29 copy number variation syndrome; Regulation of actin cytoskeleton; GDNF signaling; HDAC6 interactions in the central nervous system" "VEGFA-VEGFR2 Pathway; GAB1 signalosome; Smooth Muscle Contraction; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases; Localization of the PINCH-ILK-PARVIN complex to focal adhesions; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "21" "0" "0.902" "1.053" "0.999" "0.974" "0.968" "0.884" "0.939" "1.072" "0.906" "311.6" "281.1" "328.1" "311.3" "303.5" "301.7" "275.3" "292.6" "333.9" "282.4" "" "" "" "" "" "" "" "" "" "" "280.1" "227.5" "296.8" "303.9" "250.4" "301.7" "206.2" "258.4" "298.8" "100.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4736314326613788604" "False" "High" "IsMasterProtein" "P62277" "Small ribosomal subunit protein uS15 OS=Homo sapiens OX=9606 GN=RPS13 PE=1 SV=2" "0.000" "False" "16.130" "34" "5" "6" "5" "151" "17.2" "10.54" "19.68" "5" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00312, Pf08069" "6207" "ENSG00000110700" "RPS13" "B2R549; hsa:6207; P19116; P62277; Q02546; Q29200; Q498Y0" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.843" "0.789" "0.835" "0.829" "0.875" "0.857" "0.813" "0.872" "1.119" "755.8" "637.0" "596.0" "631.0" "626.2" "661.5" "647.6" "614.8" "659.0" "845.9" "" "" "" "" "" "" "" "" "" "" "679.5" "515.4" "539.1" "615.9" "516.8" "661.5" "484.9" "543.0" "589.7" "302.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2687801448742430149" "False" "High" "IsMasterProtein" "Q9H4A6" "Golgi phosphoprotein 3 OS=Homo sapiens OX=9606 GN=GOLPH3 PE=1 SV=1" "0.000" "False" "16.102" "18" "5" "6" "5" "298" "33.8" "6.44" "21.33" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05719" "64083" "ENSG00000113384" "GOLPH3" "hsa:64083; Q9H4A6; Q9UIW5" "" "" "0" "0" "1.101" "0.905" "1.058" "1.015" "0.969" "0.963" "1.067" "1.028" "1.112" "381.0" "419.6" "344.8" "403.2" "386.6" "369.3" "367.0" "406.7" "391.6" "423.5" "" "" "" "" "" "" "" "" "" "" "342.5" "339.5" "311.9" "393.6" "319.0" "369.3" "274.8" "359.2" "350.4" "151.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8443546389451323737" "False" "High" "IsMasterProtein" "Q96HJ9" "Protein FMC1 homolog OS=Homo sapiens OX=9606 GN=FMC1 PE=1 SV=2" "0.000" "False" "16.088" "20" "2" "4" "2" "113" "12.7" "10.07" "16.68" "2" "cell organization and biogenesis;other biological processes" "mitochondrion" "" "Pf13233" "100996928; 154791" "ENSG00000164898" "FMC1" "B7Z4Q3; hsa:100996928; hsa:154791; Q75M90; Q96HJ9; Q9P0B3" "" "" "0" "0" "0.931" "1.031" "0.814" "1.034" "1.066" "0.788" "1.004" "1.018" "0.720" "101.8" "94.8" "104.9" "82.8" "105.3" "108.5" "80.2" "102.2" "103.7" "73.2" "" "" "" "" "" "" "" "" "" "" "91.5" "76.7" "94.9" "80.9" "86.9" "108.5" "60.0" "90.3" "92.8" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5259083941231079932" "False" "High" "IsMasterProtein" "Q7Z4G1" "COMM domain-containing protein 6 OS=Homo sapiens OX=9606 GN=COMMD6 PE=1 SV=1" "0.000" "False" "16.087" "60" "5" "5" "5" "85" "9.6" "6.00" "16.50" "5" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf07258" "170622" "ENSG00000188243" "COMMD6" "A6NF28; B7ZLN0; hsa:170622; Q5TBK4; Q7Z4G1" "" "Neddylation" "1" "0" "1.092" "0.967" "1.005" "1.148" "1.064" "1.067" "1.258" "1.155" "1.170" "408.8" "446.6" "395.2" "410.8" "469.4" "434.9" "436.2" "514.3" "472.3" "478.2" "" "" "" "" "" "" "" "" "" "" "367.6" "361.4" "357.5" "401.0" "387.3" "434.9" "326.6" "454.3" "422.6" "170.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8964751153975728348" "False" "High" "IsMasterProtein" "Q96RE7" "Nucleus accumbens-associated protein 1 OS=Homo sapiens OX=9606 GN=NACC1 PE=1 SV=1" "0.000" "False" "16.086" "9" "4" "5" "4" "527" "57.2" "5.74" "19.74" "4" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651, Pf10523" "112939" "ENSG00000160877" "NACC1" "hsa:112939; Q96RE7" "" "" "0" "0" "1.089" "1.093" "0.931" "1.132" "1.054" "1.087" "1.058" "1.077" "1.383" "344.8" "375.6" "377.0" "320.9" "390.2" "363.6" "374.8" "365.0" "371.3" "476.7" "" "" "" "" "" "" "" "" "" "" "310.0" "303.9" "341.0" "313.2" "322.0" "363.6" "280.7" "322.4" "332.3" "170.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5626917880360896955" "False" "High" "IsMasterProtein" "Q8N201" "Integrator complex subunit 1 OS=Homo sapiens OX=9606 GN=INTS1 PE=1 SV=2" "0.000" "False" "16.058" "3" "7" "7" "7" "2190" "244.1" "6.13" "20.60" "7" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus" "" "Pf12432" "26173" "ENSG00000164880" "INTS1" "A6NJ44; hsa:26173; Q6NT70; Q6UX74; Q8N201; Q8WV40; Q96D36; Q9NTD1; Q9P2A8; Q9Y3W8" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.164" "1.010" "0.953" "1.293" "1.044" "1.139" "1.095" "1.050" "1.757" "99.8" "116.2" "100.8" "95.1" "129.1" "104.2" "113.6" "109.3" "104.8" "175.4" "" "" "" "" "" "" "" "" "" "" "89.7" "94.0" "91.1" "92.9" "106.5" "104.2" "85.1" "96.5" "93.8" "62.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1239746035430338710" "False" "High" "IsMasterProtein" "Q2T9J0" "Peroxisomal leader peptide-processing protease OS=Homo sapiens OX=9606 GN=TYSND1 PE=1 SV=3" "0.000" "False" "16.051" "9" "4" "4" "4" "566" "59.3" "6.20" "15.79" "4" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf13365" "219743" "ENSG00000156521" "TYSND1" "hsa:219743; Q2T9J0; Q5SQT4; Q5SQU1; Q8N6H2; Q96AR5" "" "TYSND1 cleaves peroxisomal proteins" "2" "0" "1.144" "1.063" "0.918" "1.258" "1.165" "1.233" "1.053" "1.062" "1.036" "214.7" "245.6" "228.2" "197.1" "270.0" "250.0" "264.6" "226.1" "227.9" "222.3" "" "" "" "" "" "" "" "" "" "" "193.0" "198.8" "206.4" "192.4" "222.8" "250.0" "198.2" "199.7" "204.0" "79.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8434539253909675931" "False" "High" "IsMasterProtein" "Q13588" "GRB2-related adapter protein OS=Homo sapiens OX=9606 GN=GRAP PE=1 SV=1" "0.000" "False" "16.049" "27" "5" "5" "5" "217" "25.3" "7.03" "17.93" "5" "cell-cell signaling;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00018" "10750" "ENSG00000154016" "GRAP" "hsa:10750; Q13588" "" "Signaling by SCF-KIT" "1" "0" "0.965" "0.917" "0.985" "1.159" "0.979" "0.984" "0.858" "1.017" "3.797" "176.0" "169.8" "161.3" "173.4" "204.0" "172.3" "173.2" "151.0" "179.1" "668.4" "" "" "" "" "" "" "" "" "" "" "158.2" "137.4" "145.9" "169.3" "168.3" "172.3" "129.7" "133.4" "160.2" "238.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7463522735319849849" "False" "High" "IsMasterProtein" "O15031" "Plexin-B2 OS=Homo sapiens OX=9606 GN=PLXNB2 PE=1 SV=3" "0.000" "False" "16.047" "3" "5" "5" "5" "1838" "205.0" "6.24" "14.55" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf20170" "23654" "ENSG00000196576" "PLXNB2" "A6QRH0; hsa:23654; O15031; Q7KZU3; Q9BSU7" "2q11.2 copy number variation syndrome" "" "1" "0" "0.961" "1.002" "0.965" "1.006" "0.927" "0.951" "1.017" "0.985" "0.822" "489.9" "470.7" "490.9" "472.9" "492.9" "454.3" "466.0" "498.4" "482.5" "402.8" "" "" "" "" "" "" "" "" "" "" "440.5" "380.9" "444.0" "461.6" "406.7" "454.3" "349.0" "440.2" "431.7" "143.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3246938043361698856" "False" "High" "IsMasterProtein" "O94842" "TOX high mobility group box family member 4 OS=Homo sapiens OX=9606 GN=TOX4 PE=1 SV=1" "0.000" "False" "16.046" "6" "3" "4" "2" "621" "66.2" "5.06" "17.22" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "9878" "ENSG00000092203" "TOX4" "B4DPY8; B4DSM0; E7EV69; hsa:9878; O94842" "" "" "0" "0" "0.996" "0.897" "0.913" "1.254" "1.006" "1.043" "1.033" "0.867" "1.322" "51.9" "51.7" "46.5" "47.4" "65.1" "52.2" "54.1" "53.6" "45.0" "68.6" "" "" "" "" "" "" "" "" "" "" "46.7" "41.8" "42.1" "46.3" "53.7" "52.2" "40.5" "47.3" "40.2" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7557449725087676483" "False" "High" "IsMasterProtein" "Q3MIT2" "tRNA pseudouridine synthase Pus10 OS=Homo sapiens OX=9606 GN=PUS10 PE=1 SV=1" "0.000" "False" "16.009" "11" "5" "5" "5" "529" "60.2" "6.54" "17.69" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21237, Pf21238" "150962" "ENSG00000162927" "PUS10" "hsa:150962; Q3MIT2; Q5JPJ5; Q96MI8" "" "" "0" "0" "0.994" "1.107" "0.929" "1.007" "0.957" "1.038" "0.997" "0.856" "1.148" "207.0" "205.7" "229.1" "192.2" "208.6" "198.0" "214.8" "206.5" "177.2" "237.6" "" "" "" "" "" "" "" "" "" "" "186.1" "166.4" "207.2" "187.7" "172.1" "198.0" "160.8" "182.4" "158.5" "84.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3766879511259281877" "False" "High" "IsMasterProtein" "Q96CM8" "Medium-chain acyl-CoA ligase ACSF2, mitochondrial OS=Homo sapiens OX=9606 GN=ACSF2 PE=1 SV=2" "0.000" "False" "16.002" "8" "6" "6" "6" "615" "68.1" "7.55" "19.44" "6" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "80221" "ENSG00000167107" "ACSF2" "B4DFQ6; B4DHT5; B4DUF5; hsa:80221; Q96CM8; Q9H7G2" "Mitochondrial long chain fatty acid beta-oxidation; Mitochondrial fatty acid oxidation disorders" "Mitochondrial Fatty Acid Beta-Oxidation" "3" "0" "1.044" "0.949" "0.910" "1.002" "1.051" "0.984" "0.985" "1.042" "1.306" "359.8" "375.7" "341.4" "327.4" "360.5" "378.3" "354.1" "354.6" "374.9" "469.8" "" "" "" "" "" "" "" "" "" "" "323.5" "304.0" "308.8" "319.6" "297.5" "378.3" "265.1" "313.2" "335.5" "167.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3310116821494939621" "False" "High" "IsMasterProtein" "O00584" "Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2" "0.000" "False" "15.999" "21" "5" "6" "5" "256" "29.5" "7.08" "18.24" "5" "RNA metabolism OR transcription;other metabolic processes;stress response" "non-structural extracellular;mitochondrion;ER/Golgi;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00445" "8635" "ENSG00000026297" "RNASET2" "B2RDA7; E1P5C3; hsa:8635; O00584; Q5T8Q0; Q8TCU2; Q9BZ46; Q9BZ47" "" "Neutrophil degranulation" "1" "0" "0.969" "1.026" "0.949" "0.971" "0.992" "0.963" "1.036" "1.037" "1.021" "639.3" "619.6" "655.8" "606.9" "621.1" "634.4" "615.8" "662.4" "663.1" "652.5" "" "" "" "" "" "" "" "" "" "" "574.8" "501.4" "593.2" "592.4" "512.5" "634.4" "461.1" "585.1" "593.4" "232.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-469861955524626528" "False" "High" "IsMasterProtein" "Q9BTX7" "Alpha-tocopherol transfer protein-like OS=Homo sapiens OX=9606 GN=TTPAL PE=1 SV=2" "0.000" "False" "15.992" "16" "5" "5" "5" "342" "38.5" "6.44" "16.85" "5" "" "" "other molecular function" "Pf00650, Pf03765" "79183" "ENSG00000124120" "TTPAL" "E1P5X3; hsa:79183; Q5QPC1; Q9BTX7; Q9H1G2; Q9NQG8" "" "" "0" "0" "1.564" "1.331" "1.224" "1.283" "1.550" "1.540" "1.398" "1.344" "1.461" "30.1" "47.1" "40.1" "36.9" "38.7" "46.7" "46.4" "42.1" "40.5" "44.0" "" "" "" "" "" "" "" "" "" "" "27.1" "38.1" "36.3" "36.0" "31.9" "46.7" "34.7" "37.2" "36.2" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8196142567442196869" "False" "High" "IsMasterProtein" "P20645" "Cation-dependent mannose-6-phosphate receptor OS=Homo sapiens OX=9606 GN=M6PR PE=1 SV=1" "0.000" "False" "15.983" "19" "4" "5" "4" "277" "31.0" "5.83" "19.58" "4" "transport" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02157" "4074" "ENSG00000003056" "M6PR" "A8K528; D3DUV5; hsa:4074; P20645" "" "Lysosome Vesicle Biogenesis; Cargo recognition for clathrin-mediated endocytosis; Retrograde transport at the Trans-Golgi-Network; Glycosphingolipid catabolism" "5" "0" "0.962" "0.892" "0.989" "0.906" "0.884" "1.022" "0.962" "1.013" "0.856" "449.1" "432.0" "400.8" "444.3" "406.7" "396.8" "459.0" "431.8" "455.0" "384.2" "" "" "" "" "" "" "" "" "" "" "403.8" "349.5" "362.5" "433.7" "335.7" "396.8" "343.7" "381.4" "407.1" "137.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4465081379876381336" "False" "High" "IsMasterProtein" "Q86U70" "LIM domain-binding protein 1 OS=Homo sapiens OX=9606 GN=LDB1 PE=1 SV=2" "0.000" "False" "15.945" "16" "5" "7" "5" "411" "46.5" "6.96" "13.16" "5" "cell adhesion;cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01803, Pf17916" "8861" "ENSG00000198728" "LDB1" "B4DUC4; hsa:8861; O75479; O96010; Q1EQX1; Q86U70; Q9UGM4" "" "Regulation of expression of SLITs and ROBOs; Expression and translocation of olfactory receptors; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Cardiogenesis" "4" "0" "1.038" "1.140" "0.986" "1.083" "1.309" "1.240" "1.042" "1.020" "1.031" "49.8" "51.7" "56.8" "49.1" "53.9" "65.1" "61.7" "51.9" "50.8" "51.3" "" "" "" "" "" "" "" "" "" "" "44.7" "41.8" "51.3" "47.9" "44.5" "65.1" "46.2" "45.8" "45.4" "18.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "588939397575272440" "False" "High" "IsMasterProtein" "Q7L2J0" "7SK snRNA methylphosphate capping enzyme OS=Homo sapiens OX=9606 GN=MEPCE PE=1 SV=1" "0.000" "False" "15.933" "9" "6" "7" "6" "689" "74.3" "9.57" "17.66" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "56257" "ENSG00000146834" "MEPCE" "B3KP86; D6W5V7; hsa:56257; Q7L2J0; Q9NPD4" "IL-18 signaling pathway; 1p36 copy number variation syndrome" "" "2" "0" "0.912" "0.934" "0.860" "0.915" "0.953" "0.938" "0.851" "0.886" "0.906" "175.8" "160.3" "164.2" "151.1" "160.7" "167.5" "164.9" "149.6" "155.8" "159.3" "" "" "" "" "" "" "" "" "" "" "158.0" "129.7" "148.6" "147.5" "132.6" "167.5" "123.5" "132.1" "139.4" "56.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1701299476432316153" "False" "High" "IsMasterProtein" "Q9BU61" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Homo sapiens OX=9606 GN=NDUFAF3 PE=1 SV=1" "0.000" "False" "15.922" "30" "4" "6" "4" "184" "20.3" "8.22" "20.25" "4" "cell organization and biogenesis" "other membranes;mitochondrion;nucleus" "" "Pf04430" "25915" "ENSG00000178057" "NDUFAF3" "hsa:25915; Q9BU61" "" "Complex I biogenesis" "1" "0" "1.104" "0.954" "0.985" "1.022" "1.066" "1.145" "0.990" "0.978" "1.195" "370.7" "409.2" "353.5" "365.0" "378.9" "395.3" "424.5" "366.8" "362.4" "442.8" "" "" "" "" "" "" "" "" "" "" "333.3" "331.1" "319.7" "356.3" "312.7" "395.3" "317.9" "324.0" "324.2" "158.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7682312476163043373" "False" "High" "IsMasterProtein" "P82914" "Small ribosomal subunit protein uS15m OS=Homo sapiens OX=9606 GN=MRPS15 PE=1 SV=1" "0.000" "False" "15.910" "16" "5" "6" "5" "257" "29.8" "10.48" "19.10" "5" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf00312" "64960" "ENSG00000116898" "MRPS15" "B2RD82; hsa:64960; P82914; Q9H2K1" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.972" "0.822" "1.013" "0.873" "0.792" "0.936" "0.905" "0.954" "1.223" "445.7" "433.2" "366.3" "451.3" "389.1" "353.0" "417.3" "403.5" "425.2" "545.0" "" "" "" "" "" "" "" "" "" "" "400.7" "350.5" "331.3" "440.6" "321.1" "353.0" "312.4" "356.4" "380.5" "194.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-299196629688227683" "False" "High" "IsMasterProtein" "Q9UGM6" "Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=WARS2 PE=1 SV=1" "0.000" "False" "15.854" "8" "2" "4" "2" "360" "40.1" "9.28" "16.63" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf00579" "10352" "ENSG00000116874" "WARS2" "B1ALR1; B2R9D4; hsa:10352; Q53FT4; Q5VUD2; Q86TQ0; Q9UGM6" "" "Mitochondrial tRNA aminoacylation" "1" "0" "0.981" "0.919" "0.908" "1.169" "1.102" "0.959" "1.092" "1.111" "1.093" "297.0" "291.5" "272.8" "269.8" "347.2" "327.3" "284.9" "324.3" "329.9" "324.5" "" "" "" "" "" "" "" "" "" "" "267.0" "235.8" "246.7" "263.3" "286.5" "327.3" "213.3" "286.5" "295.2" "115.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4493401864324206702" "False" "High" "IsMasterProtein" "Q53S33" "BolA-like protein 3 OS=Homo sapiens OX=9606 GN=BOLA3 PE=1 SV=1" "0.000" "False" "15.846" "39" "4" "7" "4" "107" "12.1" "9.64" "20.46" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf01722" "388962" "ENSG00000163170" "BOLA3" "G3XAB0; hsa:388962; Q53S33" "" "" "0" "0" "0.891" "0.967" "1.083" "1.111" "0.930" "0.850" "0.933" "0.929" "0.871" "118.5" "105.6" "114.6" "128.3" "131.7" "110.2" "100.8" "110.5" "110.1" "103.2" "" "" "" "" "" "" "" "" "" "" "106.6" "85.4" "103.7" "125.2" "108.6" "110.2" "75.5" "97.6" "98.5" "36.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6665456693960719485" "False" "High" "IsMasterProtein" "Q86V88" "Magnesium-dependent phosphatase 1 OS=Homo sapiens OX=9606 GN=MDP1 PE=1 SV=1" "0.000" "False" "15.837" "23" "4" "9" "4" "176" "20.1" "6.39" "27.95" "4" "" "" "other molecular function" "Pf12689" "145553" "ENSG00000213920; ENSG00000285200" "MDP1" "hsa:145553; Q86V88; Q86Y84; Q8NAD9" "" "" "0" "0" "1.003" "1.035" "1.028" "1.031" "1.004" "1.005" "1.045" "1.016" "0.924" "927.2" "930.0" "959.8" "953.4" "955.8" "930.7" "931.5" "969.0" "942.2" "856.4" "" "" "" "" "" "" "" "" "" "" "833.6" "752.5" "868.1" "930.7" "788.7" "930.7" "697.5" "855.9" "843.0" "305.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "10965468186403699" "False" "High" "IsMasterProtein" "Q8WY54" "Protein phosphatase 1E OS=Homo sapiens OX=9606 GN=PPM1E PE=1 SV=3" "0.000" "False" "15.831" "10" "4" "4" "4" "755" "83.9" "5.01" "13.35" "4" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00481" "22843" "ENSG00000175175" "PPM1E" "A7E2X1; hsa:22843; Q68DW1; Q7LAF3; Q8WY54; Q9UPT0" "" "Negative regulation of NMDA receptor-mediated neuronal transmission" "1" "0" "0.839" "0.819" "0.738" "0.775" "0.956" "0.816" "0.697" "0.862" "0.681" "73.6" "61.7" "60.3" "54.3" "57.0" "70.3" "60.0" "51.3" "63.4" "50.1" "" "" "" "" "" "" "" "" "" "" "66.2" "49.9" "54.5" "53.0" "47.1" "70.3" "44.9" "45.3" "56.8" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7973916192928746401" "False" "High" "IsMasterProtein" "Q8N6N7" "Acyl-CoA-binding domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ACBD7 PE=1 SV=1" "0.000" "False" "15.819" "42" "4" "7" "4" "88" "9.8" "6.71" "26.85" "4" "other metabolic processes" "" "other molecular function" "Pf00887" "414149" "ENSG00000176244" "ACBD7" "A6NCI2; B3KTG8; hsa:414149; Q8N6N7" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.834" "0.915" "0.964" "0.948" "0.916" "0.896" "0.984" "0.944" "0.789" "1359.4" "1134.3" "1244.3" "1310.9" "1289.1" "1245.0" "1217.5" "1338.1" "1282.9" "1072.2" "" "" "" "" "" "" "" "" "" "" "1222.2" "917.8" "1125.5" "1279.6" "1063.8" "1245.0" "911.6" "1181.9" "1147.9" "382.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7950271419257628424" "False" "High" "IsMasterProtein" "P30049" "ATP synthase subunit delta, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1D PE=1 SV=2" "0.000" "False" "15.813" "14" "2" "9" "2" "168" "17.5" "5.49" "35.72" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf02823, Pf21335" "513" "ENSG00000099624" "ATP5F1D" "D6W5Y3; hsa:513; P30049; Q6FG90" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "1.003" "0.976" "0.957" "1.000" "0.964" "1.012" "0.977" "0.957" "0.753" "1184.2" "1187.1" "1156.2" "1133.4" "1184.0" "1142.0" "1198.1" "1156.7" "1132.8" "891.4" "" "" "" "" "" "" "" "" "" "" "1064.7" "960.6" "1045.9" "1106.3" "977.0" "1142.0" "897.1" "1021.7" "1013.7" "318.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3895404278384693276" "False" "High" "IsMasterProtein" "P08047" "Transcription factor Sp1 OS=Homo sapiens OX=9606 GN=SP1 PE=1 SV=3" "0.000" "False" "15.813" "7" "4" "5" "4" "785" "80.6" "7.34" "23.79" "4" "stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6667" "ENSG00000185591" "SP1" "E4Z9M7; G5E9M8; hsa:6667; P08047; Q86TN8; Q9H3Q5; Q9NR51; Q9NY21; Q9NYE7" "Androgen receptor signaling pathway; Sterol regulatory element-binding proteins (SREBP) signaling; Leptin signaling pathway; IL-17 signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Constitutive androstane receptor pathway; Estrogen receptor pathway; Nuclear receptors meta-pathway; Myometrial relaxation and contraction pathways; Copper homeostasis; Initiation of transcription and translation elongation at the HIV-1 LTR; MECP2 and associated Rett syndrome; TGF-beta signaling pathway; Mitochondrial gene expression; Oxidative stress response; Breast cancer pathway; Ethanol metabolism production of ROS by CYP2E1; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Gastrin signaling pathway; IL-18 signaling pathway; Angiotensin II receptor type 1 pathway; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Pathways in cancer; Sudden infant death syndrome (SIDS) susceptibility pathways; Estrogen signaling pathway" "PPARA activates gene expression; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; RNA polymerase II transcribes snRNA genes; Estrogen-dependent gene expression; Oncogene Induced Senescence; Activation of gene expression by SREBF (SREBP); SARS-CoV-1 targets host intracellular signalling and regulatory pathways; Regulation of CDH11 gene transcription; NFE2L2 regulating tumorigenic genes" "42" "0" "0.907" "0.849" "1.027" "0.882" "0.885" "0.919" "0.959" "0.881" "1.126" "743.4" "674.4" "630.9" "763.3" "655.3" "657.8" "683.0" "712.5" "654.9" "836.8" "" "" "" "" "" "" "" "" "" "" "668.4" "545.7" "570.7" "745.1" "540.8" "657.8" "511.4" "629.4" "586.0" "298.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-652499996560304904" "False" "High" "IsMasterProtein" "P32969" "Large ribosomal subunit protein uL6 OS=Homo sapiens OX=9606 GN=RPL9P9 PE=1 SV=1" "0.000" "False" "15.771" "32" "5" "5" "5" "192" "21.9" "9.95" "17.49" "5" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00347" "6133" "ENSG00000163682" "RPL9; RPL9P7; RPL9P8; RPL9P9" "hsa:6133; P32969" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.012" "1.012" "0.971" "1.216" "1.093" "1.009" "1.113" "1.033" "1.143" "322.9" "326.8" "326.6" "313.4" "392.7" "352.8" "325.8" "359.3" "333.5" "368.9" "" "" "" "" "" "" "" "" "" "" "290.3" "264.5" "295.5" "305.9" "324.1" "352.8" "244.0" "317.3" "298.4" "131.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6769080269671987288" "False" "High" "IsMasterProtein" "Q9NVP1" "ATP-dependent RNA helicase DDX18 OS=Homo sapiens OX=9606 GN=DDX18 PE=1 SV=2" "0.000" "False" "15.766" "8" "5" "6" "5" "670" "75.4" "9.50" "15.30" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf13959" "8886" "ENSG00000088205" "DDX18" "hsa:8886; Q6GTZ9; Q6IAU4; Q92732; Q9BQB7; Q9NVP1" "" "" "0" "0" "1.090" "0.980" "0.916" "1.012" "1.275" "1.100" "0.912" "0.994" "0.769" "309.1" "337.0" "302.8" "283.2" "312.7" "394.0" "339.9" "281.7" "307.1" "237.6" "" "" "" "" "" "" "" "" "" "" "277.9" "272.7" "273.8" "276.4" "258.0" "394.0" "254.5" "248.8" "274.7" "84.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8173179408617438185" "False" "High" "IsMasterProtein" "P32929" "Cystathionine gamma-lyase OS=Homo sapiens OX=9606 GN=CTH PE=1 SV=3" "0.000" "False" "15.762" "12" "4" "5" "4" "405" "44.5" "6.70" "15.68" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf01053" "1491" "ENSG00000116761" "CTH" "B4E1R2; E9PDV0; hsa:1491; P32929; Q53FB3; Q53Y79; Q9H4W7; Q9H4W8" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Trans-sulfuration pathway; Trans-sulfuration, one-carbon metabolism and related pathways; Amino acid metabolism; One-carbon metabolism and related pathways; Methionine metabolism leading to sulfur amino acids and related disorders; Ferroptosis" "Degradation of cysteine and homocysteine; Metabolism of ingested SeMet, Sec, MeSec into H2Se; Cysteine formation from homocysteine" "12" "0" "0.970" "0.997" "0.971" "1.102" "1.066" "1.066" "1.025" "0.966" "0.938" "182.5" "177.0" "181.9" "177.1" "201.1" "194.5" "194.5" "187.1" "176.4" "171.2" "" "" "" "" "" "" "" "" "" "" "164.1" "143.2" "164.6" "172.9" "166.0" "194.5" "145.6" "165.3" "157.8" "61.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4353457585173966729" "False" "High" "IsMasterProtein" "P84101" "Small EDRK-rich factor 2 OS=Homo sapiens OX=9606 GN=SERF2 PE=1 SV=1" "0.000" "False" "15.724" "31" "3" "11" "3" "59" "6.9" "10.45" "30.94" "3" "other biological processes" "cytosol;nucleus" "" "Pf04419" "10169" "ENSG00000140264" "SERF2" "A6NL45; B5MCG1; B9A026; hsa:10169; O75918; O88891; P84101; Q9BZH7" "" "" "0" "0" "0.931" "1.013" "0.965" "0.928" "1.098" "0.957" "0.988" "0.965" "0.831" "900.6" "838.1" "912.0" "869.4" "835.7" "988.4" "861.7" "890.1" "869.3" "748.4" "" "" "" "" "" "" "" "" "" "" "809.7" "678.2" "824.9" "848.6" "689.7" "988.4" "645.2" "786.2" "777.8" "267.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3246576723643333795" "False" "High" "IsMasterProtein" "Q8N668" "COMM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=COMMD1 PE=1 SV=1" "0.000" "False" "15.697" "29" "4" "5" "4" "190" "21.2" "6.20" "21.06" "4" "DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07258, Pf17221" "150684" "ENSG00000173163" "COMMD1" "B4DFQ4; hsa:150684; Q8N668; Q96GS0" "Copper homeostasis; 1p36 copy number variation syndrome" "Neddylation" "3" "0" "1.083" "0.966" "0.943" "1.118" "1.076" "1.042" "1.006" "1.092" "1.117" "498.3" "539.8" "481.3" "469.7" "556.9" "535.9" "519.2" "501.5" "544.2" "556.6" "" "" "" "" "" "" "" "" "" "" "448.0" "436.8" "435.4" "458.5" "459.6" "535.9" "388.7" "442.9" "486.9" "198.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "289518910119416826" "False" "High" "IsMasterProtein" "P61966" "AP-1 complex subunit sigma-1A OS=Homo sapiens OX=9606 GN=AP1S1 PE=1 SV=1" "0.000" "False" "15.645" "25" "4" "9" "3" "158" "18.7" "5.73" "32.72" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "1174" "ENSG00000106367" "AP1S1" "B2R5D8; hsa:1174; P61966; P82267; Q00382; Q53YA7; Q9BTN4; Q9UDW9" "" "Lysosome Vesicle Biogenesis; MHC class II antigen presentation; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.119" "1.117" "0.990" "1.040" "0.969" "1.146" "1.065" "1.008" "1.154" "877.0" "981.4" "979.5" "868.0" "911.8" "849.6" "1004.7" "934.3" "884.1" "1012.4" "" "" "" "" "" "" "" "" "" "" "788.5" "794.1" "885.9" "847.3" "752.4" "849.6" "752.3" "825.2" "791.1" "361.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3764290193644051117" "False" "High" "IsMasterProtein" "Q8WU10" "Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PYROXD1 PE=1 SV=1" "0.000" "False" "15.616" "11" "4" "4" "4" "500" "55.8" "5.85" "13.34" "4" "stress response" "cytoskeleton;nucleus" "other molecular function" "Pf07992, Pf18267" "79912" "ENSG00000121350" "PYROXD1" "A6NKI6; B3KWN8; hsa:79912; Q8WU10; Q9H6P1" "" "" "0" "0" "1.157" "1.142" "1.048" "1.084" "1.095" "0.835" "1.150" "1.372" "1.448" "164.2" "190.0" "187.4" "172.0" "178.0" "179.8" "137.0" "188.8" "225.3" "237.7" "" "" "" "" "" "" "" "" "" "" "147.6" "153.7" "169.5" "167.9" "146.9" "179.8" "102.6" "166.8" "201.6" "84.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7042305927855089094" "False" "High" "IsMasterProtein" "Q96E09" "PPP2R1A-PPP2R2A-interacting phosphatase regulator 1 OS=Homo sapiens OX=9606 GN=PABIR1 PE=1 SV=1" "0.000" "False" "15.603" "11" "4" "6" "4" "287" "30.5" "6.79" "19.53" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity" "" "116224" "ENSG00000187866" "PABIR1" "hsa:116224; Q96E09" "" "" "0" "0" "1.070" "0.997" "1.003" "1.083" "1.056" "0.963" "1.022" "1.068" "0.934" "448.5" "479.8" "447.1" "450.1" "485.8" "473.5" "432.0" "458.5" "479.2" "418.7" "" "" "" "" "" "" "" "" "" "" "403.3" "388.3" "404.4" "439.4" "400.9" "473.5" "323.5" "405.0" "428.8" "149.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3124234521907955571" "False" "High" "IsMasterProtein" "Q9NX24" "H/ACA ribonucleoprotein complex subunit 2 OS=Homo sapiens OX=9606 GN=NHP2 PE=1 SV=1" "0.000" "False" "15.578" "24" "3" "4" "3" "153" "17.2" "8.22" "17.53" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01248" "55651" "ENSG00000145912" "NHP2" "A6NKY8; hsa:55651; Q9NX24; Q9P095" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.889" "0.969" "0.829" "0.869" "0.966" "0.886" "0.907" "0.871" "1.092" "637.5" "567.1" "618.1" "528.6" "554.2" "615.8" "564.6" "578.4" "555.1" "696.3" "" "" "" "" "" "" "" "" "" "" "573.2" "458.8" "559.1" "516.0" "457.3" "615.8" "422.7" "510.9" "496.7" "248.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2292593222020041360" "False" "High" "IsMasterProtein" "Q92925" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 OS=Homo sapiens OX=9606 GN=SMARCD2 PE=1 SV=3" "0.000" "False" "15.569" "13" "5" "5" "5" "531" "58.9" "9.64" "18.96" "5" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02201" "6603" "ENSG00000108604" "SMARCD2" "A5PLL5; A6NNQ7; B4DV56; B4E1R6; hsa:6603; Q7L2I6; Q92925; Q9UHZ1" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.911" "0.927" "0.907" "0.987" "0.885" "1.027" "0.811" "0.798" "4.773" "279.3" "254.5" "258.9" "253.4" "275.7" "247.3" "286.7" "226.5" "222.9" "1333.0" "" "" "" "" "" "" "" "" "" "" "251.1" "205.9" "234.2" "247.3" "227.5" "247.3" "214.7" "200.0" "199.4" "475.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5625038226073765913" "False" "High" "IsMasterProtein" "P61421" "V-type proton ATPase subunit d 1 OS=Homo sapiens OX=9606 GN=ATP6V0D1 PE=1 SV=1" "0.000" "False" "15.547" "15" "5" "5" "5" "351" "40.3" "5.00" "15.53" "5" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf01992" "9114" "ENSG00000159720" "ATP6V0D1" "hsa:9114; P12953; P61421; Q02547" "VEGFA-VEGFR2 signaling" "Amino acids regulate mTORC1; XBP1(S) activates chaperone genes; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "7" "0" "1.252" "1.173" "1.135" "1.159" "1.028" "1.167" "1.163" "1.328" "2.153" "141.8" "177.6" "166.4" "161.0" "164.4" "145.8" "165.5" "165.0" "188.4" "305.4" "" "" "" "" "" "" "" "" "" "" "127.5" "143.7" "150.5" "157.2" "135.7" "145.8" "123.9" "145.7" "168.6" "109.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9194587147899025830" "False" "High" "IsMasterProtein" "P30613" "Pyruvate kinase PKLR OS=Homo sapiens OX=9606 GN=PKLR PE=1 SV=2" "0.000" "False" "15.544" "4" "4" "20" "1" "574" "61.8" "7.74" "56.73" "4" "other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00224, Pf02887" "5313" "ENSG00000143627; ENSG00000262785" "PKLR" "hsa:5313; O75758; P11973; P30613" "Clear cell renal cell carcinoma pathways; Nonalcoholic fatty liver disease; 7q11.23 copy number variation syndrome; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "" "5" "0" "1.120" "0.897" "0.980" "1.254" "0.871" "0.914" "1.020" "1.102" "0.847" "72.0" "80.6" "64.6" "70.6" "90.3" "62.7" "65.8" "73.4" "79.3" "61.0" "" "" "" "" "" "" "" "" "" "" "64.7" "65.2" "58.4" "68.9" "74.5" "62.7" "49.3" "64.8" "71.0" "21.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-827121188594037217" "False" "High" "IsMasterProtein" "Q6P1R4" "tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens OX=9606 GN=DUS1L PE=1 SV=1" "0.000" "False" "15.544" "18" "6" "6" "6" "473" "53.2" "8.29" "19.01" "6" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01207" "64118" "ENSG00000169718" "DUS1L" "A6NHV4; hsa:64118; Q6P1R4; Q96AI3" "" "" "0" "0" "1.116" "1.102" "1.030" "1.130" "1.122" "1.140" "1.066" "1.095" "1.050" "415.6" "464.0" "458.0" "428.1" "469.7" "466.3" "473.8" "443.0" "455.3" "436.4" "" "" "" "" "" "" "" "" "" "" "373.7" "375.5" "414.3" "417.8" "387.6" "466.3" "354.8" "391.3" "407.4" "155.8" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801504579459921117" "False" "High" "IsMasterProtein" "Q8IXQ3" "Uncharacterized protein C9orf40 OS=Homo sapiens OX=9606 GN=C9orf40 PE=1 SV=1" "0.000" "False" "15.530" "33" "4" "4" "4" "194" "21.1" "5.01" "14.80" "4" "" "" "" "Pf15017" "55071" "ENSG00000135045" "C9orf40" "hsa:55071; Q8IXQ3; Q9NWD3" "" "" "0" "0" "1.046" "0.956" "0.988" "1.109" "0.961" "1.027" "1.098" "0.987" "0.890" "274.0" "286.5" "261.9" "270.7" "303.8" "263.2" "281.4" "300.8" "270.3" "243.8" "" "" "" "" "" "" "" "" "" "" "246.3" "231.8" "236.9" "264.3" "250.7" "263.2" "210.7" "265.7" "241.9" "87.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6808375425283248797" "False" "High" "IsMasterProtein" "Q13572" "Inositol-tetrakisphosphate 1-kinase OS=Homo sapiens OX=9606 GN=ITPK1 PE=1 SV=2" "0.000" "False" "15.521" "14" "4" "5" "4" "414" "45.6" "6.16" "16.42" "4" "other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf05770, Pf17927" "3705" "ENSG00000100605; ENSG00000274958" "ITPK1" "hsa:3705; Q13572; Q9BTL6; Q9H2E7" "2q37 copy number variation syndrome" "Factors involved in megakaryocyte development and platelet production; Synthesis of IP3 and IP4 in the cytosol; Synthesis of pyrophosphates in the cytosol" "4" "0" "1.081" "1.049" "1.059" "1.054" "1.070" "1.087" "1.137" "0.998" "1.109" "272.0" "293.9" "285.3" "288.0" "286.7" "291.1" "295.6" "309.3" "271.3" "301.6" "" "" "" "" "" "" "" "" "" "" "244.5" "237.9" "258.1" "281.2" "236.6" "291.1" "221.3" "273.2" "242.8" "107.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "307320246962858459" "False" "High" "IsMasterProtein" "Q6UWZ7" "BRCA1-A complex subunit Abraxas 1 OS=Homo sapiens OX=9606 GN=ABRAXAS1 PE=1 SV=2" "0.000" "False" "15.497" "13" "5" "5" "5" "409" "46.6" "7.05" "14.49" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "cytoskeletal activity;other molecular function" "Pf21125" "84142" "ENSG00000163322" "ABRAXAS1" "A5JJ07; hsa:84142; Q6UWZ7; Q9H8I1; Q9H9N4" "5q35 copy number variation" "Nonhomologous End-Joining (NHEJ); Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Metalloprotease DUBs; Processing of DNA double-strand break ends; G2/M DNA damage checkpoint" "6" "0" "0.988" "0.910" "0.992" "1.015" "1.014" "1.011" "1.054" "0.880" "0.910" "431.3" "426.1" "392.5" "428.0" "437.9" "437.5" "436.2" "454.5" "379.4" "392.5" "" "" "" "" "" "" "" "" "" "" "387.8" "344.8" "355.0" "417.8" "361.3" "437.5" "326.6" "401.5" "339.5" "140.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731116703421718606" "False" "High" "IsMasterProtein" "Q53H80" "Akirin-2 OS=Homo sapiens OX=9606 GN=AKIRIN2 PE=1 SV=2" "0.000" "False" "15.463" "20" "4" "6" "3" "203" "22.5" "8.73" "16.62" "4" "protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "" "55122" "ENSG00000135334" "AKIRIN2" "hsa:55122; Q53H80; Q9BQB1" "" "" "0" "2" "0.938" "0.824" "1.032" "0.972" "0.859" "1.002" "1.001" "0.856" "1.057" "679.9" "637.5" "560.2" "701.8" "660.7" "584.0" "681.5" "680.3" "582.3" "718.9" "" "" "" "" "" "" "" "" "" "" "611.3" "515.9" "506.7" "685.1" "545.2" "584.0" "510.3" "600.9" "521.0" "256.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4696215040566855502" "False" "High" "IsMasterProtein" "Q9H446" "RWD domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RWDD1 PE=1 SV=1" "0.000" "False" "15.463" "13" "4" "7" "4" "243" "27.9" "4.20" "22.99" "4" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "" "Pf05773, Pf16543" "51389" "ENSG00000111832" "RWDD1" "A8K3W2; A8MT24; hsa:51389; Q9H446; Q9Y313; Q9Y6B3" "" "Protein hydroxylation" "1" "0" "1.076" "1.007" "1.026" "1.134" "1.041" "1.132" "1.150" "1.197" "0.875" "726.8" "781.8" "732.0" "745.4" "824.4" "756.8" "823.0" "835.5" "870.1" "635.8" "" "" "" "" "" "" "" "" "" "" "653.4" "632.6" "662.1" "727.6" "680.3" "756.8" "616.2" "738.0" "778.6" "227.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3311968132693307525" "False" "High" "IsMasterProtein" "P42773" "Cyclin-dependent kinase 4 inhibitor C OS=Homo sapiens OX=9606 GN=CDKN2C PE=1 SV=1" "0.000" "False" "15.461" "23" "5" "7" "5" "168" "18.1" "6.52" "24.33" "5" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12796" "1031" "ENSG00000123080" "CDKN2C" "hsa:1031; P42773; Q8TB83" "Cell cycle; Glioblastoma signaling pathways; Vitamin D receptor pathway; G1 to S cell cycle control" "Oxidative Stress Induced Senescence; Oncogene Induced Senescence; Cyclin D associated events in G1; Senescence-Associated Secretory Phenotype (SASP)" "8" "0" "0.911" "0.888" "0.915" "0.959" "0.924" "0.942" "0.985" "0.871" "0.724" "760.7" "692.7" "675.8" "696.0" "729.2" "702.8" "716.8" "749.4" "662.8" "550.7" "" "" "" "" "" "" "" "" "" "" "684.0" "560.5" "611.3" "679.4" "601.7" "702.8" "536.7" "661.9" "593.0" "196.6" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2766829585988969351" "False" "High" "IsMasterProtein" "O75190" "DnaJ homolog subfamily B member 6 OS=Homo sapiens OX=9606 GN=DNAJB6 PE=1 SV=2" "0.000" "False" "15.455" "15" "4" "6" "3" "326" "36.1" "9.16" "14.78" "4" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00226" "10049" "ENSG00000105993" "DNAJB6" "A4D232; A8K7D8; A8KAG0; B4DN73; E9PCZ2; hsa:10049; O75190; O95806; Q53EN8; Q59EF2; Q6FIC8; Q75MA2; Q9UIK6" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.811" "0.723" "0.740" "0.787" "0.831" "0.914" "0.845" "0.868" "0.899" "58.7" "47.6" "42.5" "43.4" "46.2" "48.8" "53.7" "49.6" "51.0" "52.8" "" "" "" "" "" "" "" "" "" "" "52.8" "38.5" "38.4" "42.4" "38.2" "48.8" "40.2" "43.8" "45.6" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108294970833743211" "False" "High" "IsMasterProtein" "Q5XUX1" "F-box/WD repeat-containing protein 9 OS=Homo sapiens OX=9606 GN=FBXW9 PE=1 SV=3" "0.000" "False" "15.425" "12" "6" "7" "5" "458" "50.7" "6.48" "14.55" "6" "" "cytosol" "" "Pf00400, Pf12937" "84261" "ENSG00000132004" "FBXW9" "B3KVP7; hsa:84261; Q5XUX1; Q9BT89" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.001" "1.098" "1.034" "1.042" "1.083" "1.057" "1.063" "1.069" "0.978" "337.6" "338.0" "370.8" "349.0" "351.7" "365.6" "356.8" "358.9" "361.1" "330.1" "" "" "" "" "" "" "" "" "" "" "303.6" "273.5" "335.4" "340.6" "290.2" "365.6" "267.2" "317.0" "323.1" "117.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4646306898255403066" "False" "High" "IsMasterProtein" "Q96FF9" "Sororin OS=Homo sapiens OX=9606 GN=CDCA5 PE=1 SV=1" "0.000" "False" "15.423" "17" "3" "4" "3" "252" "27.6" "9.61" "19.70" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09666" "113130" "ENSG00000146670" "CDCA5" "A8K625; hsa:113130; Q96FF9" "" "Resolution of Sister Chromatid Cohesion; Separation of Sister Chromatids; Establishment of Sister Chromatid Cohesion" "3" "0" "1.006" "1.347" "0.931" "1.019" "1.321" "1.075" "0.991" "1.338" "0.999" "426.3" "428.9" "574.4" "397.0" "434.4" "562.9" "458.2" "422.3" "570.3" "425.8" "" "" "" "" "" "" "" "" "" "" "383.3" "347.1" "519.6" "387.5" "358.5" "562.9" "343.1" "373.0" "510.3" "152.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330394968015135701" "False" "High" "IsMasterProtein" "Q9P2R3" "Rabankyrin-5 OS=Homo sapiens OX=9606 GN=ANKFY1 PE=1 SV=2" "0.000" "False" "15.401" "5" "6" "8" "6" "1169" "128.3" "6.10" "18.11" "6" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00023, Pf00651, Pf01363, Pf12796" "51479" "ENSG00000185722" "ANKFY1" "A8KA65; hsa:51479; Q5RKV4; Q9P2R3; Q9ULG5" "" "RHOD GTPase cycle" "1" "0" "1.117" "1.098" "0.999" "1.078" "1.154" "1.135" "0.975" "1.113" "4.640" "306.1" "341.9" "336.2" "305.9" "330.1" "353.1" "347.5" "298.5" "340.8" "1420.3" "" "" "" "" "" "" "" "" "" "" "275.2" "276.7" "304.1" "298.6" "272.4" "353.1" "260.2" "263.7" "304.9" "507.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1227162241055397784" "False" "High" "IsMasterProtein" "Q9H0W8" "Nonsense-mediated mRNA decay factor SMG9 OS=Homo sapiens OX=9606 GN=SMG9 PE=1 SV=1" "0.000" "False" "15.376" "8" "3" "4" "3" "520" "57.6" "7.01" "14.89" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol" "other molecular function" "" "56006" "ENSG00000105771" "SMG9" "hsa:56006; O60429; Q9H0W8; Q9H9A9" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.923" "0.938" "1.004" "1.046" "0.991" "1.028" "0.923" "0.877" "1.226" "220.7" "203.6" "207.0" "221.6" "230.9" "218.6" "226.9" "203.7" "193.5" "270.5" "" "" "" "" "" "" "" "" "" "" "198.4" "164.7" "187.2" "216.3" "190.6" "218.6" "169.9" "179.9" "173.1" "96.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054198857384115692" "False" "High" "IsMasterProtein" "O14492" "SH2B adapter protein 2 OS=Homo sapiens OX=9606 GN=SH2B2 PE=1 SV=2" "0.000" "False" "15.373" "8" "4" "4" "4" "632" "67.7" "6.27" "16.68" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00017, Pf00169, Pf08916" "10603" "ENSG00000160999" "SH2B2" "A0A0A0MTI2; A6ND74; O14492" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Kit receptor signaling pathway; Insulin signaling" "Regulation of KIT signaling; Factors involved in megakaryocyte development and platelet production" "5" "0" "0.976" "0.904" "1.092" "0.952" "0.939" "1.152" "0.860" "0.862" "3.756" "130.2" "127.1" "117.7" "142.3" "124.0" "122.3" "150.1" "112.0" "112.3" "489.2" "" "" "" "" "" "" "" "" "" "" "117.1" "102.9" "106.4" "138.9" "102.3" "122.3" "112.4" "98.9" "100.5" "174.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2767038677570436707" "False" "High" "IsMasterProtein" "P82663" "Small ribosomal subunit protein mS25 OS=Homo sapiens OX=9606 GN=MRPS25 PE=1 SV=1" "0.000" "False" "15.371" "30" "4" "6" "4" "173" "20.1" "8.82" "18.71" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "64432" "ENSG00000131368" "MRPS25" "B4DFJ5; B4DQG6; hsa:64432; P82663; Q9H7P5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.949" "1.055" "0.984" "1.045" "1.077" "1.080" "1.072" "1.060" "1.311" "502.9" "477.4" "530.5" "495.0" "525.7" "541.7" "543.0" "539.3" "533.0" "659.4" "" "" "" "" "" "" "" "" "" "" "452.1" "386.3" "479.8" "483.2" "433.8" "541.7" "406.6" "476.4" "477.0" "235.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7398915680383575894" "False" "High" "IsMasterProtein" "Q5BKX5" "Actin maturation protease OS=Homo sapiens OX=9606 GN=ACTMAP PE=1 SV=2" "0.000" "False" "15.370" "18" "4" "4" "4" "351" "37.8" "7.47" "17.40" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf21646" "284325" "ENSG00000188493" "ACTMAP" "A8MSZ5; B4DNU7; hsa:284325; Q5BKX5" "" "" "0" "0" "0.948" "0.938" "0.926" "0.993" "0.971" "0.984" "0.901" "0.969" "1.188" "202.1" "191.5" "189.5" "187.0" "200.7" "196.2" "198.9" "182.2" "195.7" "240.0" "" "" "" "" "" "" "" "" "" "" "181.7" "154.9" "171.5" "182.6" "165.6" "196.2" "148.9" "160.9" "175.1" "85.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-631503824976752333" "False" "High" "IsMasterProtein" "Q9BYD2" "Large ribosomal subunit protein bL9m OS=Homo sapiens OX=9606 GN=MRPL9 PE=1 SV=2" "0.000" "False" "15.370" "13" "3" "4" "3" "267" "30.2" "10.08" "18.17" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01281" "65005" "ENSG00000143436" "MRPL9" "B2RD99; hsa:65005; Q5SZR2; Q9BSW8; Q9BYD2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.861" "0.911" "0.869" "0.911" "0.782" "0.971" "0.937" "0.912" "0.974" "224.8" "193.5" "204.9" "195.3" "204.9" "175.9" "218.4" "210.6" "205.1" "219.0" "" "" "" "" "" "" "" "" "" "" "202.2" "156.6" "185.3" "190.7" "169.1" "175.9" "163.5" "186.0" "183.5" "78.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2670793063602377093" "False" "High" "IsMasterProtein" "Q8TBZ6" "tRNA methyltransferase 10 homolog A OS=Homo sapiens OX=9606 GN=TRMT10A PE=1 SV=1" "0.000" "False" "15.359" "14" "4" "6" "4" "339" "39.7" "7.65" "19.67" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01746" "93587" "ENSG00000145331" "TRMT10A" "B2R8X7; hsa:93587; Q8TBZ6; Q9Y2T9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.037" "0.982" "1.057" "0.995" "1.237" "1.034" "1.104" "0.944" "0.798" "294.3" "305.1" "289.0" "311.2" "292.9" "364.1" "304.3" "325.1" "277.9" "234.9" "" "" "" "" "" "" "" "" "" "" "264.6" "246.9" "261.4" "303.7" "241.7" "364.1" "227.9" "287.1" "248.7" "83.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3431457210334272148" "False" "High" "IsMasterProtein" "Q75QN2" "Integrator complex subunit 8 OS=Homo sapiens OX=9606 GN=INTS8 PE=1 SV=1" "0.000" "False" "15.353" "5" "5" "6" "5" "995" "113.0" "7.05" "18.52" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "" "" "55656" "ENSG00000164941" "INTS8" "B2RN92; hsa:55656; Q5RKZ3; Q6P1R5; Q75QN2; Q7Z314; Q9NVS6; Q9NWY7" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.994" "0.982" "0.982" "1.044" "0.910" "0.924" "1.061" "0.939" "1.130" "330.3" "328.2" "324.4" "324.2" "344.8" "300.5" "305.2" "350.5" "310.2" "373.2" "" "" "" "" "" "" "" "" "" "" "297.0" "265.6" "293.4" "316.5" "284.6" "300.5" "228.5" "309.6" "277.6" "133.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2458914006646188126" "False" "High" "IsMasterProtein" "Q9NYV6" "RNA polymerase I-specific transcription initiation factor RRN3 OS=Homo sapiens OX=9606 GN=RRN3 PE=1 SV=1" "0.000" "False" "15.339" "7" "4" "5" "4" "651" "74.1" "5.63" "17.88" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf05327" "54700" "ENSG00000085721; ENSG00000278494" "RRN3" "A2RTY9; B4E0J7; B4E3T2; hsa:54700; Q3MHU9; Q6IPL4; Q9H4F0; Q9NYV6" "" "RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape" "2" "0" "1.204" "1.832" "0.950" "1.093" "1.728" "1.038" "0.988" "1.841" "1.780" "150.9" "181.7" "276.5" "143.3" "164.9" "260.8" "156.7" "149.1" "277.8" "268.6" "" "" "" "" "" "" "" "" "" "" "135.7" "147.1" "250.1" "139.9" "136.1" "260.8" "117.3" "131.7" "248.6" "95.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9014101916445181907" "False" "High" "IsMasterProtein" "Q6BDS2" "Bridge-like lipid transfer protein family member 3A OS=Homo sapiens OX=9606 GN=BLTP3A PE=1 SV=1" "0.000" "False" "15.339" "4" "5" "5" "5" "1440" "159.4" "6.14" "17.90" "5" "" "other cytoplasmic organelle" "other molecular function" "Pf12624" "54887" "ENSG00000065060" "BLTP3A" "hsa:54887; Q6BDS2; Q9NXE0" "" "" "0" "0" "1.048" "1.082" "0.948" "1.025" "0.982" "1.043" "0.994" "1.045" "1.105" "363.0" "380.4" "392.8" "344.1" "372.1" "356.4" "378.4" "360.7" "379.4" "401.2" "" "" "" "" "" "" "" "" "" "" "326.4" "307.8" "355.3" "335.9" "307.0" "356.4" "283.4" "318.6" "339.5" "143.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9189940377941500292" "False" "High" "IsMasterProtein" "Q9Y3D6" "Mitochondrial fission 1 protein OS=Homo sapiens OX=9606 GN=FIS1 PE=1 SV=2" "0.000" "False" "15.316" "16" "2" "4" "2" "152" "16.9" "8.79" "17.71" "2" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf14852, Pf14853" "51024" "ENSG00000214253" "FIS1" "hsa:51024; Q9BTP3; Q9Y3D6" "CAMKK2 pathway" "Class I peroxisomal membrane protein import" "2" "0" "0.935" "0.969" "0.996" "0.884" "1.082" "0.992" "0.946" "1.025" "0.842" "447.6" "418.3" "433.7" "445.7" "395.5" "484.3" "444.2" "423.6" "458.6" "376.8" "" "" "" "" "" "" "" "" "" "" "402.4" "338.4" "392.3" "435.1" "326.3" "484.3" "332.6" "374.1" "410.3" "134.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1224423870794083930" "False" "High" "IsMasterProtein" "P49356" "Protein farnesyltransferase subunit beta OS=Homo sapiens OX=9606 GN=FNTB PE=1 SV=1" "0.000" "False" "15.298" "10" "4" "5" "4" "437" "48.7" "5.82" "17.04" "4" "protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00432" "100529261; 2342" "ENSG00000257365" "FNTB" "B2RDX6; B4E1A0; hsa:100529261; hsa:2342; P49356" "" "Potential therapeutics for SARS; Inactivation, recovery and regulation of the phototransduction cascade; RAS processing" "3" "0" "1.037" "0.999" "1.021" "1.012" "0.895" "1.023" "0.967" "0.962" "1.067" "323.2" "335.1" "322.8" "329.9" "327.3" "289.3" "330.8" "312.6" "310.9" "344.9" "" "" "" "" "" "" "" "" "" "" "290.6" "271.2" "292.0" "322.0" "270.1" "289.3" "247.7" "276.1" "278.2" "123.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2434298641534178381" "False" "High" "IsMasterProtein" "P42336" "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PIK3CA PE=1 SV=2" "0.000" "False" "15.293" "5" "5" "5" "5" "1068" "124.2" "7.23" "15.27" "5" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00454, Pf00613, Pf00792, Pf00794, Pf02192" "5290" "ENSG00000121879" "PIK3CA" "hsa:5290; P42336; Q14CW1; Q99762" "AMP-activated protein kinase signaling; Angiogenesis; MicroRNAs in cardiomyocyte hypertrophy; Sterol regulatory element-binding proteins (SREBP) signaling; Thyroid stimulating hormone (TSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; IL-17 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; IL1 and megakaryocytes in obesity; Transcriptional activation by NRF2 in response to phytochemicals; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; RAC1/PAK1/p38/MMP2 pathway; Pathways affected in adenoid cystic carcinoma; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Fibrin complement receptor 3 signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ebola virus infection in host; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; NRF2-ARE regulation; Nonalcoholic fatty liver disease; Resistin as a regulator of inflammation; Relationship between inflammation, COX-2 and EGFR; Synaptic signaling pathways associated with autism spectrum disorder; Overview of interferons-mediated signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Translation inhibitors in chronically activated PDGFRA cells; Cancer immunotherapy by CTLA4 blockade; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; Osteoblast differentiation and related diseases; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; Regucalcin in proximal tubule epithelial kidney cells; Kisspeptin/kisspeptin receptor system in the ovary; Kallmann syndrome; Pleural mesothelioma; Regulation of actin cytoskeleton; Congenital generalized lipodystrophy; Familial partial lipodystrophy; Alzheimer's disease; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Warburg effect modulated by deubiquitinating enzymes and their substrates; G13 signaling pathway; Comprehensive IL-17A signaling; Acute myeloid leukemia; IL-26 signaling pathways; Osteoarthritic chondrocyte hypertrophy; GNAQ pathways in port-wine stain; ErbB signaling pathway; DNA damage response (only ATM dependent); Estrogen signaling pathway; Serotonin HTR1 group and FOS pathway; Toll-like receptor signaling pathway" "Role of phospholipids in phagocytosis; Role of LAT2/NTAL/LAB on calcium mobilization; Signaling by ALK fusions and activated point mutants; Downstream TCR signaling; RAC1 GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; Extra-nuclear estrogen signaling; PIP3 activates AKT signaling; Synthesis of PIPs at the plasma membrane; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RET signaling; Erythropoietin activates Phosphoinositide-3-kinase (PI3K); Interleukin receptor SHC signaling; Regulation of signaling by CBL; Nephrin family interactions; RAF/MAP kinase cascade; PI3K Cascade; GPVI-mediated activation cascade; Signaling by SCF-KIT; Downstream signal transduction; PI3K/AKT activation; Signaling by ALK; Tie2 Signaling; DAP12 signaling; Costimulation by the CD28 family; CD28 dependent PI3K/Akt signaling; VEGFA-VEGFR2 Pathway; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; PI3K events in ERBB4 signaling; PI3K events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; GAB1 signalosome; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; PI-3K cascade:FGFR1; PI-3K cascade:FGFR2; Signaling by FGFR2 in disease; PI-3K cascade:FGFR3; PI-3K cascade:FGFR4; Signaling by FGFR3 in disease; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; Signaling by FGFR4 in disease; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; MET activates PI3K/AKT signaling; Activated NTRK3 signals through PI3K; Activated NTRK2 signals through PI3K" "140" "0" "1.237" "1.058" "0.907" "1.285" "1.188" "1.073" "1.037" "1.155" "1.417" "250.6" "309.9" "265.1" "227.4" "322.1" "297.7" "269.0" "259.8" "289.4" "355.2" "" "" "" "" "" "" "" "" "" "" "225.3" "250.8" "239.7" "222.0" "265.8" "297.7" "201.4" "229.5" "259.0" "126.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4871053517443562380" "False" "High" "IsMasterProtein" "P57772" "Selenocysteine-specific elongation factor OS=Homo sapiens OX=9606 GN=EEFSEC PE=1 SV=4" "0.000" "False" "15.281" "11" "7" "8" "7" "596" "65.3" "8.35" "22.81" "7" "protein metabolism;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00009, Pf03144, Pf21131, Pf21208" "60678" "ENSG00000132394; ENSG00000284869" "EEFSEC" "hsa:60678; P57772; Q96HZ6" "Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "2" "0" "1.084" "1.222" "0.861" "0.998" "0.985" "1.130" "0.874" "1.053" "1.324" "35.7" "38.7" "43.6" "30.7" "35.6" "35.2" "40.3" "31.2" "37.6" "47.2" "" "" "" "" "" "" "" "" "" "" "32.1" "31.3" "39.5" "30.0" "29.4" "35.2" "30.2" "27.6" "33.6" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7548254055495868617" "False" "High" "IsMasterProtein" "Q9BZD4" "Kinetochore protein Nuf2 OS=Homo sapiens OX=9606 GN=NUF2 PE=1 SV=2" "0.000" "False" "15.271" "12" "6" "6" "6" "464" "54.3" "8.27" "16.58" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf03800" "83540" "ENSG00000143228" "NUF2" "hsa:83540; Q8WU69; Q96HJ4; Q96Q78; Q9BZD4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.953" "1.071" "0.987" "0.896" "1.069" "1.084" "0.955" "1.052" "5.925" "197.2" "187.9" "211.1" "194.6" "176.6" "210.8" "213.8" "188.3" "207.4" "1168.2" "" "" "" "" "" "" "" "" "" "" "177.3" "152.1" "191.0" "189.9" "145.8" "210.8" "160.1" "166.4" "185.6" "417.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2435727542331039410" "False" "High" "IsMasterProtein" "O00522" "Krev interaction trapped protein 1 OS=Homo sapiens OX=9606 GN=KRIT1 PE=1 SV=2" "0.000" "False" "15.255" "6" "5" "5" "5" "736" "84.3" "8.41" "15.23" "5" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00023, Pf00373, Pf16705" "889" "ENSG00000001631" "KRIT1" "A6NNU0; hsa:889; O00522; O43894; Q506L6; Q6U276; Q75N19; Q9H180; Q9H264; Q9HAX5" "" "" "0" "0" "1.038" "1.084" "0.988" "1.071" "0.987" "1.032" "1.016" "1.096" "1.204" "503.4" "522.6" "545.8" "497.3" "539.1" "496.7" "519.5" "511.6" "551.7" "605.9" "" "" "" "" "" "" "" "" "" "" "452.6" "422.8" "493.7" "485.5" "444.9" "496.7" "389.0" "451.9" "493.7" "216.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6713486079386730204" "False" "High" "IsMasterProtein" "P50454" "Serpin H1 OS=Homo sapiens OX=9606 GN=SERPINH1 PE=1 SV=2" "0.000" "False" "15.254" "13" "5" "5" "5" "418" "46.4" "8.69" "14.61" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes" "non-structural extracellular;other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00079" "871" "ENSG00000149257" "SERPINH1" "B3KVJ3; hsa:871; P29043; P50454; Q5XPB4; Q6NSJ6; Q8IY96; Q9NP88" "Endochondral ossification; Type I collagen synthesis in the context of osteogenesis imperfecta; Endochondral ossification with skeletal dysplasias; 15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "Collagen biosynthesis and modifying enzymes" "6" "0" "0.984" "0.926" "0.881" "0.945" "0.934" "0.952" "0.959" "1.102" "0.833" "308.7" "303.8" "285.8" "272.1" "291.9" "288.3" "293.8" "296.2" "340.4" "257.2" "" "" "" "" "" "" "" "" "" "" "277.6" "245.8" "258.5" "265.6" "240.9" "288.3" "220.0" "261.6" "304.6" "91.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7972073683050353884" "False" "High" "IsMasterProtein" "Q9NYP3" "Protein downstream neighbor of Son OS=Homo sapiens OX=9606 GN=DONSON PE=1 SV=2" "0.000" "False" "15.237" "9" "4" "5" "4" "566" "62.7" "8.66" "16.71" "4" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction" "nucleus;other cell component" "" "" "29980" "ENSG00000159147" "DONSON" "hsa:29980; Q8NC53; Q9NSR9; Q9NVZ5; Q9NYP1; Q9NYP2; Q9NYP3" "" "" "0" "0" "0.899" "1.533" "0.852" "1.013" "1.408" "0.911" "0.868" "1.508" "0.653" "109.0" "98.0" "167.1" "92.9" "110.4" "153.5" "99.4" "94.7" "164.4" "71.2" "" "" "" "" "" "" "" "" "" "" "98.0" "79.3" "151.2" "90.7" "91.1" "153.5" "74.4" "83.6" "147.1" "25.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229408047793123568" "False" "High" "IsMasterProtein" "O75155" "Cullin-associated NEDD8-dissociated protein 2 OS=Homo sapiens OX=9606 GN=CAND2 PE=1 SV=3" "0.000" "False" "15.235" "3" "3" "9" "2" "1236" "135.2" "5.68" "28.77" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08623" "23066" "ENSG00000144712" "CAND2" "B9EGM9; E9KL24; hsa:23066; O75155" "" "" "0" "0" "1.084" "0.923" "0.935" "1.067" "0.932" "1.007" "0.974" "1.085" "1.681" "113.1" "122.6" "104.5" "105.8" "120.8" "105.4" "114.0" "110.2" "122.7" "190.1" "" "" "" "" "" "" "" "" "" "" "101.7" "99.2" "94.5" "103.3" "99.7" "105.4" "85.4" "97.4" "109.8" "67.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7866416472238112790" "False" "High" "IsMasterProtein" "Q14061" "Cytochrome c oxidase copper chaperone OS=Homo sapiens OX=9606 GN=COX17 PE=1 SV=2" "0.000" "False" "15.223" "32" "2" "11" "2" "63" "6.9" "7.24" "38.71" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf05051" "10063" "ENSG00000138495" "COX17" "B2R5D2; D3DN84; hsa:10063; Q14061; Q3MHD6" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis; IL-18 signaling pathway; Mitochondrial complex IV assembly" "Mitochondrial protein import" "5" "0" "1.002" "1.038" "1.009" "1.043" "1.021" "1.049" "1.097" "1.005" "0.920" "1092.1" "1094.4" "1134.1" "1101.6" "1139.3" "1114.6" "1145.9" "1198.2" "1097.4" "1005.2" "" "" "" "" "" "" "" "" "" "" "981.9" "885.6" "1025.9" "1075.3" "940.1" "1114.6" "858.0" "1058.3" "981.9" "358.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1639956808395934598" "False" "High" "IsMasterProtein" "Q9UKT4" "F-box only protein 5 OS=Homo sapiens OX=9606 GN=FBXO5 PE=1 SV=1" "0.000" "False" "15.206" "13" "6" "6" "6" "447" "50.1" "8.92" "16.08" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00646" "26271" "ENSG00000112029" "FBXO5" "B3KNX5; hsa:26271; Q5TF47; Q8WV29; Q9UGC8; Q9UKT4" "" "SCF-beta-TrCP mediated degradation of Emi1; G1/S-Specific Transcription; Phosphorylation of Emi1; Mitotic Metaphase/Anaphase Transition" "5" "0" "1.003" "1.211" "0.930" "1.037" "1.215" "0.983" "1.018" "1.292" "0.885" "352.1" "353.0" "426.3" "327.4" "365.2" "427.9" "346.0" "358.4" "454.9" "311.6" "" "" "" "" "" "" "" "" "" "" "316.6" "285.6" "385.6" "319.6" "301.4" "427.9" "259.1" "316.6" "407.0" "111.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4527223765443096832" "False" "High" "IsMasterProtein" "O95785" "Protein Wiz OS=Homo sapiens OX=9606 GN=WIZ PE=1 SV=2" "0.000" "False" "15.205" "5" "6" "6" "6" "1651" "178.6" "6.86" "17.61" "6" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "58525" "ENSG00000011451" "WIZ" "B3KVH1; B7ZM82; hsa:58525; M0QY21; O95785; Q4G0E0; Q6P6B0; Q6ZN24; Q7LDY6; Q7LDZ1; Q96IG5; Q96SQ6; Q9BUR8; Q9NPT1" "" "" "0" "0" "0.984" "0.871" "0.911" "1.021" "0.914" "0.930" "0.910" "0.919" "0.934" "263.5" "259.2" "229.4" "239.9" "269.1" "240.8" "245.1" "239.7" "242.1" "246.1" "" "" "" "" "" "" "" "" "" "" "236.9" "209.8" "207.5" "234.2" "222.1" "240.8" "183.6" "211.7" "216.6" "87.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172904709922305924" "False" "High" "IsMasterProtein" "Q5UIP0" "Telomere-associated protein RIF1 OS=Homo sapiens OX=9606 GN=RIF1 PE=1 SV=2" "0.000" "False" "15.196" "3" "6" "7" "6" "2472" "274.3" "5.52" "21.10" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf12231" "55183" "ENSG00000080345" "RIF1" "A6NC27; C9JBR1; hsa:55183; Q5H9R3; Q5UIP0; Q5UIP2; Q66YK6; Q6PRU2; Q8TE94; Q99772; Q9H830; Q9H9B9; Q9NVP5; Q9Y4R4" "ATM signaling in development and disease ; 10q11.21q11.23 copy number variation syndrome" "Nonhomologous End-Joining (NHEJ)" "3" "0" "1.057" "1.030" "1.047" "1.015" "0.962" "1.100" "0.853" "0.886" "2.850" "518.0" "547.3" "533.3" "542.4" "525.9" "498.5" "569.7" "441.9" "458.8" "1476.5" "" "" "" "" "" "" "" "" "" "" "465.7" "442.8" "482.4" "529.4" "434.0" "498.5" "426.6" "390.3" "410.5" "527.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1428811385271777844" "False" "High" "IsMasterProtein" "Q9H488" "GDP-fucose protein O-fucosyltransferase 1 OS=Homo sapiens OX=9606 GN=POFUT1 PE=1 SV=1" "0.000" "False" "15.182" "14" "4" "4" "4" "388" "43.9" "8.53" "20.21" "4" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23509" "ENSG00000101346" "POFUT1" "A8K4R8; E1P5M4; hsa:23509; Q14685; Q5W185; Q9BW76; Q9H488" "" "Pre-NOTCH Processing in the Endoplasmic Reticulum" "1" "0" "0.989" "1.055" "0.975" "1.017" "1.077" "1.030" "1.072" "1.013" "0.774" "888.4" "879.1" "937.6" "866.4" "903.2" "957.1" "915.2" "952.6" "900.4" "687.3" "" "" "" "" "" "" "" "" "" "" "798.8" "711.3" "848.1" "845.7" "745.3" "957.1" "685.3" "841.4" "805.7" "245.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6685402705848511390" "False" "High" "IsMasterProtein" "Q92820" "Gamma-glutamyl hydrolase OS=Homo sapiens OX=9606 GN=GGH PE=1 SV=2" "0.000" "False" "15.131" "16" "5" "5" "5" "318" "35.9" "7.11" "16.66" "5" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00117, Pf07722" "8836" "ENSG00000137563" "GGH" "hsa:8836; Q92820" "Fluoropyrimidine activity" "Neutrophil degranulation" "2" "0" "1.019" "1.194" "1.018" "1.106" "1.025" "1.044" "0.942" "1.160" "0.863" "556.7" "567.4" "664.7" "566.8" "616.0" "570.9" "581.3" "524.5" "645.6" "480.2" "" "" "" "" "" "" "" "" "" "" "500.6" "459.2" "601.2" "553.3" "508.3" "570.9" "435.3" "463.2" "577.6" "171.4" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8134550695814129755" "False" "High" "IsMasterProtein" "P30519" "Heme oxygenase 2 OS=Homo sapiens OX=9606 GN=HMOX2 PE=1 SV=2" "0.000" "False" "15.122" "16" "4" "4" "4" "316" "36.0" "5.41" "16.98" "4" "other metabolic processes;stress response" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01126" "3163" "ENSG00000103415; ENSG00000277424" "HMOX2" "A8MT35; D3DUD5; hsa:3163; I3L430; O60605; P30519" "" "RHOA GTPase cycle; Neutrophil degranulation; Cytoprotection by HMOX1; Iron uptake and transport; Heme degradation" "5" "0" "0.860" "0.812" "0.927" "0.993" "0.937" "1.118" "0.959" "0.836" "0.785" "224.6" "193.1" "182.3" "208.1" "223.0" "210.4" "251.2" "215.3" "187.7" "176.3" "" "" "" "" "" "" "" "" "" "" "202.0" "156.3" "164.9" "203.2" "184.0" "210.4" "188.1" "190.2" "168.0" "63.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6755213045612558311" "False" "High" "IsMasterProtein" "P53367" "Arfaptin-1 OS=Homo sapiens OX=9606 GN=ARFIP1 PE=1 SV=2" "0.000" "False" "15.066" "13" "5" "6" "4" "373" "41.7" "6.70" "21.02" "5" "transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf06456" "27236" "ENSG00000164144" "ARFIP1" "B4DS69; hsa:27236; P53367; Q2M2X4; Q3SYL4; Q9Y2X6" "" "" "0" "0" "0.991" "1.028" "0.994" "1.015" "0.963" "1.083" "0.924" "1.054" "1.991" "243.7" "241.5" "250.5" "242.1" "247.3" "234.6" "263.9" "225.2" "256.9" "485.1" "" "" "" "" "" "" "" "" "" "" "219.1" "195.4" "226.6" "236.4" "204.1" "234.6" "197.6" "198.9" "229.9" "173.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141064915599705120" "False" "High" "IsMasterProtein" "Q9P000" "COMM domain-containing protein 9 OS=Homo sapiens OX=9606 GN=COMMD9 PE=1 SV=2" "0.000" "False" "15.065" "31" "5" "5" "5" "198" "21.8" "5.88" "16.46" "5" "transport;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf07258, Pf20923" "29099" "ENSG00000110442" "COMMD9" "E9PAN2; hsa:29099; Q96FI2; Q9H0R0; Q9P000" "" "Neddylation; Neutrophil degranulation" "2" "0" "0.981" "0.997" "0.932" "1.093" "1.040" "1.125" "1.086" "0.958" "0.858" "194.9" "191.2" "194.3" "181.7" "213.0" "202.6" "219.3" "211.7" "186.6" "167.3" "" "" "" "" "" "" "" "" "" "" "175.2" "154.7" "175.8" "177.4" "175.8" "202.6" "164.2" "187.0" "167.0" "59.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3393024407889637945" "False" "High" "IsMasterProtein" "P63027" "Vesicle-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=VAMP2 PE=1 SV=3" "0.000" "False" "15.021" "34" "3" "4" "2" "116" "12.7" "8.13" "18.59" "3" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6844" "ENSG00000220205" "VAMP2" "hsa:6844; P19065; P63027; Q9BUC2" "Synaptic vesicle pathway; Insulin signaling; 7q11.23 copy number variation syndrome; Galanin receptor pathway; Vasopressin-regulated water reabsorption; Sudden infant death syndrome (SIDS) susceptibility pathways" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation; Sensory processing of sound by inner hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Regulation of insulin secretion; Insulin processing; Cargo recognition for clathrin-mediated endocytosis; Other interleukin signaling; Toxicity of tetanus toxin (tetX); Toxicity of botulinum toxin type B (botB); Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "28" "0" "0.901" "1.009" "0.978" "1.040" "0.987" "0.928" "1.097" "1.096" "0.784" "277.7" "250.2" "280.3" "271.6" "288.9" "274.2" "257.7" "304.8" "304.4" "217.6" "" "" "" "" "" "" "" "" "" "" "249.7" "202.4" "253.5" "265.1" "238.4" "274.2" "193.0" "269.2" "272.4" "77.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5259121706082363690" "False" "High" "IsMasterProtein" "Q6NS38" "DNA oxidative demethylase ALKBH2 OS=Homo sapiens OX=9606 GN=ALKBH2 PE=1 SV=1" "0.000" "False" "15.016" "16" "3" "4" "3" "261" "29.3" "9.66" "15.33" "3" "DNA metabolism;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13532" "121642" "ENSG00000189046" "ALKBH2" "A4PET2; hsa:121642; Q5XLE3; Q6NS38" "Direct reversal repair" "ALKBH2 mediated reversal of alkylation damage" "2" "0" "1.010" "0.935" "1.087" "1.205" "0.931" "1.051" "1.054" "0.977" "1.798" "331.5" "334.9" "309.8" "360.2" "399.3" "308.6" "348.5" "349.4" "323.9" "595.9" "" "" "" "" "" "" "" "" "" "" "298.0" "271.0" "280.2" "351.6" "329.5" "308.6" "260.9" "308.6" "289.8" "212.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8875331277631851835" "False" "High" "IsMasterProtein" "O75113" "NEDD4-binding protein 1 OS=Homo sapiens OX=9606 GN=N4BP1 PE=1 SV=4" "0.000" "False" "15.015" "4" "4" "5" "4" "896" "100.3" "5.36" "14.98" "4" "stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf11977" "9683" "ENSG00000102921" "N4BP1" "A7MD49; hsa:9683; O75113; Q2YDX1" "" "Regulation of NF-kappa B signaling" "1" "0" "1.002" "1.112" "1.005" "1.073" "1.077" "1.010" "0.991" "1.058" "1.435" "331.7" "332.4" "368.9" "333.4" "355.8" "357.4" "334.9" "328.6" "350.9" "476.2" "" "" "" "" "" "" "" "" "" "" "298.3" "269.0" "333.7" "325.4" "293.6" "357.4" "250.8" "290.3" "314.0" "170.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5151232376153751801" "False" "High" "IsMasterProtein" "Q9UIM3" "FK506-binding protein-like OS=Homo sapiens OX=9606 GN=FKBPL PE=1 SV=1" "0.000" "False" "15.012" "13" "5" "5" "5" "349" "38.2" "5.50" "16.88" "5" "other biological processes" "non-structural extracellular;cytosol" "" "Pf00515" "63943" "ENSG00000204315; ENSG00000223666; ENSG00000224200; ENSG00000230907" "FKBPL" "A8K5V3; B0UYX8; hsa:63943; Q9H5G3; Q9UIM3" "" "The role of GTSE1 in G2/M progression after G2 checkpoint" "1" "0" "0.980" "0.956" "0.942" "0.963" "1.042" "1.033" "1.028" "1.029" "0.979" "721.4" "707.1" "689.7" "679.4" "694.8" "751.4" "745.5" "741.7" "741.9" "706.0" "" "" "" "" "" "" "" "" "" "" "648.6" "572.1" "623.9" "663.2" "573.3" "751.4" "558.2" "655.1" "663.9" "252.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4844902181037291409" "False" "High" "IsMasterProtein" "P62314" "Small nuclear ribonucleoprotein Sm D1 OS=Homo sapiens OX=9606 GN=SNRPD1 PE=1 SV=1" "0.000" "False" "14.999" "37" "4" "5" "4" "119" "13.3" "11.56" "21.10" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf01423" "6632" "ENSG00000167088" "SNRPD1" "B5BTZ1; hsa:6632; P13641; P62314" "mRNA processing" "mRNA Splicing - Major Pathway; snRNP Assembly; SARS-CoV-2 modulates host translation machinery; mRNA Splicing - Minor Pathway" "5" "0" "1.014" "0.936" "0.978" "1.071" "1.028" "1.067" "0.991" "1.043" "0.820" "300.6" "304.8" "281.5" "293.9" "321.8" "309.1" "320.7" "297.8" "313.6" "246.5" "" "" "" "" "" "" "" "" "" "" "270.3" "246.6" "254.6" "286.9" "265.6" "309.1" "240.1" "263.0" "280.6" "88.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1657158777638447925" "False" "High" "IsMasterProtein" "P20273" "B-cell receptor CD22 OS=Homo sapiens OX=9606 GN=CD22 PE=1 SV=2" "0.000" "False" "14.995" "5" "4" "5" "4" "847" "95.3" "6.65" "15.48" "4" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13895, Pf13927" "933" "ENSG00000012124" "CD22" "F5GYU4; F5H7U3; hsa:933; O95699; O95701; O95702; O95703; P20273; Q01665; Q32M46; Q92872; Q92873; Q9UQA6; Q9UQA7; Q9UQA8; Q9UQA9; Q9UQB0; Q9Y2A6" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "5" "0" "1.030" "1.078" "1.100" "0.987" "1.017" "1.116" "1.088" "1.046" "0.876" "414.9" "427.4" "447.4" "456.5" "409.7" "422.1" "463.2" "451.3" "433.9" "363.5" "" "" "" "" "" "" "" "" "" "" "373.0" "345.8" "404.7" "445.6" "338.1" "422.1" "346.9" "398.6" "388.3" "129.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6709781459489319409" "False" "High" "IsMasterProtein" "Q9UHN1" "DNA polymerase subunit gamma-2 OS=Homo sapiens OX=9606 GN=POLG2 PE=1 SV=1" "0.000" "False" "14.994" "12" "6" "7" "6" "485" "54.9" "8.35" "17.08" "6" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "mitochondrion;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf03129" "11232" "ENSG00000256525" "POLG2" "hsa:11232; O00419; Q0IJ81; Q96GW2; Q9UHN1; Q9UK35; Q9UK94" "" "Transcriptional activation of mitochondrial biogenesis" "1" "0" "1.006" "1.010" "0.975" "1.045" "0.985" "1.072" "0.993" "0.950" "1.011" "618.1" "622.1" "624.0" "602.3" "645.9" "608.7" "662.3" "613.5" "587.2" "624.6" "" "" "" "" "" "" "" "" "" "" "555.7" "503.4" "564.5" "588.0" "533.0" "608.7" "495.9" "541.9" "525.4" "223.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2137073451658822686" "False" "High" "IsMasterProtein" "Q01664" "Transcription factor AP-4 OS=Homo sapiens OX=9606 GN=TFAP4 PE=1 SV=2" "0.000" "False" "14.984" "14" "5" "5" "5" "338" "38.7" "5.87" "18.37" "5" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "7023" "ENSG00000090447" "TFAP4" "hsa:7023; O60409; Q01664" "DYRK1A involvement regarding cell proliferation in brain development" "" "1" "0" "1.035" "0.796" "0.897" "1.093" "0.864" "1.065" "0.970" "0.739" "1.327" "279.7" "289.3" "222.8" "250.8" "305.7" "241.8" "297.9" "271.2" "206.7" "371.0" "" "" "" "" "" "" "" "" "" "" "251.5" "234.1" "201.5" "244.8" "252.3" "241.8" "223.1" "239.5" "184.9" "132.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157020147431294409" "False" "High" "IsMasterProtein" "P17028" "Zinc finger protein 24 OS=Homo sapiens OX=9606 GN=ZNF24 PE=1 SV=4" "0.000" "False" "14.965" "13" "5" "5" "5" "368" "42.1" "6.21" "17.98" "5" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf02023" "7572" "ENSG00000172466" "ZNF24" "hsa:7572; O14754; P17028; Q53YE4; Q6ICR5; Q8IZN4" "" "" "0" "0" "0.986" "0.904" "0.964" "1.003" "0.983" "0.896" "0.941" "0.980" "0.942" "622.3" "613.3" "562.4" "599.7" "624.3" "611.9" "557.6" "585.3" "610.1" "586.2" "" "" "" "" "" "" "" "" "" "" "559.5" "496.2" "508.7" "585.4" "515.2" "611.9" "417.5" "517.0" "545.9" "209.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4446297038364687966" "False" "High" "IsMasterProtein" "Q9NPA8" "Transcription and mRNA export factor ENY2 OS=Homo sapiens OX=9606 GN=ENY2 PE=1 SV=1" "0.000" "False" "14.962" "39" "4" "5" "4" "101" "11.5" "9.33" "20.03" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf10163" "56943" "ENSG00000120533" "ENY2" "B2RE52; G3V117; hsa:56943; Q9NPA8" "" "HATs acetylate histones" "1" "0" "0.964" "1.086" "0.997" "1.116" "1.044" "1.126" "1.095" "1.033" "0.795" "369.0" "355.9" "400.8" "368.0" "411.7" "385.2" "415.4" "404.0" "381.4" "293.4" "" "" "" "" "" "" "" "" "" "" "331.8" "288.0" "362.5" "359.2" "339.7" "385.2" "311.0" "356.9" "341.2" "104.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2210481861453836415" "False" "High" "IsMasterProtein" "Q9BVM2" "Protein DPCD OS=Homo sapiens OX=9606 GN=DPCD PE=1 SV=2" "0.000" "False" "14.960" "19" "4" "6" "4" "203" "23.2" "9.03" "20.48" "4" "transport;developmental processes;other biological processes" "non-structural extracellular" "" "Pf14913" "25911" "ENSG00000166171" "DPCD" "A8K289; hsa:25911; Q6QNL3; Q8N5R1; Q9BVM2; Q9UFY6" "" "" "0" "0" "0.963" "0.904" "1.032" "0.963" "0.919" "0.980" "0.968" "0.940" "1.553" "295.5" "284.5" "267.2" "305.1" "284.7" "271.6" "289.7" "286.1" "277.8" "458.8" "" "" "" "" "" "" "" "" "" "" "265.7" "230.2" "241.7" "297.8" "234.9" "271.6" "216.9" "252.7" "248.6" "163.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5375440904508103637" "False" "High" "IsMasterProtein" "Q6ZSJ8" "Uncharacterized protein C1orf122 OS=Homo sapiens OX=9606 GN=C1orf122 PE=1 SV=2" "0.000" "False" "14.931" "39" "4" "6" "4" "110" "11.5" "6.73" "21.98" "4" "" "" "" "Pf15855" "127687" "ENSG00000197982" "C1orf122" "A2RQF4; E9PQ13; hsa:127687; Q56A71; Q6ZSJ8" "" "" "0" "0" "1.053" "0.967" "0.861" "0.903" "1.243" "1.147" "1.040" "1.097" "1.055" "92.4" "97.3" "89.4" "79.6" "83.4" "114.9" "106.0" "96.1" "101.4" "97.5" "" "" "" "" "" "" "" "" "" "" "83.1" "78.7" "80.9" "77.7" "68.8" "114.9" "79.4" "84.9" "90.7" "34.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7159036767897580858" "False" "High" "IsMasterProtein" "P20036" "HLA class II histocompatibility antigen, DP alpha 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPA1 PE=1 SV=1" "0.000" "False" "14.930" "7" "2" "5" "2" "260" "29.4" "5.21" "18.70" "2" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00993, Pf07654" "3113" "ENSG00000168384; ENSG00000206291; ENSG00000224103; ENSG00000228163; ENSG00000229685; ENSG00000231389; ENSG00000235844; ENSG00000236177" "HLA-DPA1" "A9YWH7; B9UKH4; O19722; O46883; P01905; P20036; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; Q9BCQ1; Q9TPX3; Q9XS10" "Allograft rejection; Ebola virus infection in host" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "9" "0" "0.947" "0.954" "1.058" "0.956" "0.971" "1.026" "1.066" "0.990" "0.810" "892.5" "845.3" "851.2" "944.1" "853.5" "866.3" "915.8" "951.2" "883.2" "722.8" "" "" "" "" "" "" "" "" "" "" "802.5" "684.0" "769.9" "921.6" "704.3" "866.3" "685.8" "840.1" "790.3" "258.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8771434071682940528" "False" "High" "IsMasterProtein" "O95294" "RasGAP-activating-like protein 1 OS=Homo sapiens OX=9606 GN=RASAL1 PE=1 SV=3" "0.000" "False" "14.928" "6" "4" "4" "4" "804" "90.0" "6.51" "13.42" "4" "signal transduction;other biological processes" "cytosol" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "8437" "ENSG00000111344" "RASAL1" "B7ZKM4; C9JFK5; F8VQX1; hsa:8437; O95294; Q52M03; Q59H24; Q96CC7" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "1.026" "1.083" "0.987" "1.044" "0.990" "1.117" "0.928" "1.010" "1.592" "234.3" "240.5" "253.8" "231.2" "244.7" "231.9" "261.7" "217.6" "236.6" "373.2" "" "" "" "" "" "" "" "" "" "" "210.7" "194.6" "229.6" "225.7" "201.9" "231.9" "195.9" "192.2" "211.7" "133.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6915758716299824080" "False" "High" "IsMasterProtein" "Q06787" "Fragile X messenger ribonucleoprotein 1 OS=Homo sapiens OX=9606 GN=FMR1 PE=1 SV=1" "0.000" "False" "14.922" "9" "5" "5" "4" "632" "71.1" "7.42" "16.24" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity;translation activity;nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16098, Pf17904, Pf18336" "2332" "ENSG00000102081" "FMR1" "A6NNH4; D3DWT0; D3DWT1; D3DWT2; G8JL90; hsa:2332; Q06787; Q16578; Q5PQZ6; Q99054" "Ovarian infertility; Serotonin and anxiety; Prader-Willi and Angelman syndrome; Fragile X syndrome; Disruption of postsynaptic signaling by CNV; 15q11.2 copy number variation syndrome; Primary ovarian insufficiency" "" "7" "0" "1.067" "0.974" "0.841" "0.905" "1.059" "0.883" "0.907" "0.940" "0.856" "95.8" "102.3" "93.3" "80.6" "86.7" "101.5" "84.6" "86.9" "90.1" "82.0" "" "" "" "" "" "" "" "" "" "" "86.2" "82.8" "84.4" "78.7" "71.5" "101.5" "63.4" "76.7" "80.6" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1845643412684317790" "False" "High" "IsMasterProtein" "P49674" "Casein kinase I isoform epsilon OS=Homo sapiens OX=9606 GN=CSNK1E PE=1 SV=1" "0.000" "False" "14.906" "13" "5" "5" "2" "416" "47.3" "9.66" "16.73" "5" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "102800317; 1454" "ENSG00000213923" "CSNK1E" "hsa:102800317; hsa:1454; P49674" "Alzheimer's disease and miRNA effects; Melatonin metabolism and effects; Wnt signaling pathway; Wnt signaling pathway and pluripotency; Hedgehog signaling pathway; lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease" "Major pathway of rRNA processing in the nucleolus and cytosol; WNT mediated activation of DVL; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock" "20" "1" "1.030" "1.012" "1.020" "1.103" "1.156" "1.053" "1.004" "1.022" "1.223" "319.7" "329.3" "323.5" "326.2" "352.5" "369.7" "336.6" "320.9" "326.8" "391.0" "" "" "" "" "" "" "" "" "" "" "287.4" "266.4" "292.6" "318.4" "290.9" "369.7" "252.1" "283.4" "292.4" "139.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3774842769131475239" "False" "High" "IsMasterProtein" "Q9Y2R5" "Small ribosomal subunit protein uS17m OS=Homo sapiens OX=9606 GN=MRPS17 PE=1 SV=1" "0.000" "False" "14.877" "38" "4" "5" "4" "130" "14.5" "9.85" "19.49" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity" "Pf00366" "51373" "ENSG00000239789" "MRPS17" "hsa:51373; Q86X15; Q9Y2R5" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.037" "1.035" "0.930" "1.014" "0.991" "1.110" "0.957" "1.217" "1.323" "44.9" "46.6" "46.5" "41.8" "45.5" "44.5" "49.8" "43.0" "54.7" "59.4" "" "" "" "" "" "" "" "" "" "" "40.4" "37.7" "42.1" "40.8" "37.6" "44.5" "37.3" "38.0" "48.9" "21.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3000409602916512702" "False" "High" "IsMasterProtein" "O15357" "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2" "0.000" "False" "14.872" "4" "5" "6" "4" "1258" "138.5" "6.54" "18.71" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00017, Pf00536" "3636" "ENSG00000165458" "INPPL1" "B2RTX5; hsa:3636; O15357; Q13577; Q13578" "EGF/EGFR signaling pathway; Insulin signaling" "Synthesis of PIPs at the plasma membrane; Interleukin receptor SHC signaling; Synthesis of IP3 and IP4 in the cytosol; Signaling by CSF1 (M-CSF) in myeloid cells" "6" "0" "1.168" "1.126" "1.024" "1.278" "1.040" "1.221" "1.181" "1.168" "2.475" "143.5" "167.7" "161.6" "146.9" "183.3" "149.3" "175.3" "169.5" "167.7" "355.1" "" "" "" "" "" "" "" "" "" "" "129.0" "135.7" "146.1" "143.4" "151.3" "149.3" "131.2" "149.7" "150.0" "126.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4342326397945372791" "False" "High" "IsMasterProtein" "O75150" "E3 ubiquitin-protein ligase BRE1B OS=Homo sapiens OX=9606 GN=RNF40 PE=1 SV=5" "0.000" "False" "14.846" "4" "3" "4" "2" "1001" "113.6" "6.29" "16.13" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097" "9810" "ENSG00000103549" "RNF40" "A0A024QZG0; hsa:9810; O75150; Q6AHZ6; Q6N005; Q7L3T6; Q8N615; Q96T18; Q9BSV9; Q9HC82" "ATM signaling in development and disease" "E3 ubiquitin ligases ubiquitinate target proteins" "2" "0" "1.101" "0.968" "1.010" "0.934" "0.979" "1.058" "0.893" "0.869" "2.523" "73.6" "81.0" "71.2" "74.3" "68.8" "72.1" "77.9" "65.7" "64.0" "185.7" "" "" "" "" "" "" "" "" "" "" "66.2" "65.6" "64.4" "72.5" "56.7" "72.1" "58.3" "58.1" "57.2" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7460825629413537855" "False" "High" "IsMasterProtein" "Q9BV40" "Vesicle-associated membrane protein 8 OS=Homo sapiens OX=9606 GN=VAMP8 PE=1 SV=1" "0.000" "False" "14.815" "29" "3" "10" "3" "100" "11.4" "7.34" "28.46" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00957" "8673" "ENSG00000118640" "VAMP8" "hsa:8673; O60625; Q53SP9; Q6IB09; Q9BV40" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Neutrophil degranulation; ER-Phagosome pathway; Cargo recognition for clathrin-mediated endocytosis; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis" "8" "0" "0.962" "0.943" "0.995" "1.006" "0.925" "1.053" "1.021" "0.892" "0.765" "1031.2" "992.4" "972.5" "1025.5" "1037.2" "954.0" "1085.7" "1052.5" "920.3" "788.7" "" "" "" "" "" "" "" "" "" "" "927.1" "803.0" "879.7" "1001.1" "855.9" "954.0" "813.0" "929.6" "823.5" "281.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8978349436204480078" "False" "High" "IsMasterProtein" "Q13148" "TAR DNA-binding protein 43 OS=Homo sapiens OX=9606 GN=TARDBP PE=1 SV=1" "0.000" "False" "14.814" "8" "4" "5" "4" "414" "44.7" "6.19" "16.65" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf18694, Pf20910" "23435" "ENSG00000120948" "TARDBP" "A4GUK4; A4GUK5; A4GUK6; B2R629; B4DJ45; E2PU12; hsa:23435; Q13148; Q53H27; Q6FI92; Q96DJ0" "MECP2 and associated Rett syndrome; HDAC6 interactions in the central nervous system" "" "2" "0" "1.001" "0.965" "0.904" "0.991" "1.049" "1.060" "0.874" "1.030" "11.330" "467.3" "467.7" "450.9" "422.7" "462.9" "490.2" "495.1" "408.3" "481.5" "5294.7" "" "" "" "" "" "" "" "" "" "" "420.1" "378.4" "407.9" "412.6" "382.0" "490.2" "370.7" "360.6" "430.9" "1890.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5372839880175933062" "False" "High" "IsMasterProtein" "Q9NUK0" "Muscleblind-like protein 3 OS=Homo sapiens OX=9606 GN=MBNL3 PE=1 SV=2" "0.000" "False" "14.783" "10" "4" "8" "1" "354" "38.5" "8.81" "27.08" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf14608, Pf18044" "55796" "ENSG00000076770" "MBNL3" "hsa:55796; Q5JXN8; Q5JXN9; Q5JXP4; Q6UDQ1; Q8IUR4; Q8TAD9; Q8TAF4; Q9H0Z7; Q9NUK0; Q9UF37" "" "" "0" "0" "1.017" "1.087" "1.191" "1.081" "0.932" "1.168" "1.185" "1.129" "1.215" "68.9" "70.1" "74.9" "82.1" "74.5" "64.2" "80.5" "81.6" "77.8" "83.7" "" "" "" "" "" "" "" "" "" "" "61.9" "56.7" "67.7" "80.1" "61.5" "64.2" "60.3" "72.1" "69.6" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7104112355135180301" "False" "High" "IsMasterProtein" "Q9UL26" "Ras-related protein Rab-22A OS=Homo sapiens OX=9606 GN=RAB22A PE=1 SV=2" "0.000" "False" "14.769" "28" "5" "5" "5" "194" "21.8" "8.15" "19.40" "5" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "57403" "ENSG00000124209" "RAB22A" "B3KR86; E1P605; hsa:57403; Q8TF12; Q9H4E6; Q9UL26" "" "RAB geranylgeranylation" "1" "0" "1.024" "1.065" "0.967" "1.030" "1.023" "1.026" "0.998" "1.010" "1.055" "317.5" "325.0" "338.3" "307.0" "327.0" "324.7" "325.8" "316.8" "320.8" "335.0" "" "" "" "" "" "" "" "" "" "" "285.5" "262.9" "306.0" "299.7" "269.8" "324.7" "244.0" "279.9" "287.0" "119.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421989768094974956" "False" "High" "IsMasterProtein" "Q96BM9" "ADP-ribosylation factor-like protein 8A OS=Homo sapiens OX=9606 GN=ARL8A PE=1 SV=1" "0.000" "False" "14.741" "23" "4" "5" "1" "186" "21.4" "7.77" "19.13" "4" "cell cycle OR cell proliferation;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00025" "127829" "ENSG00000143862" "ARL8A" "B3KXD0; hsa:127829; Q96BM9" "" "Neutrophil degranulation" "1" "0" "1.161" "1.142" "1.275" "1.010" "1.108" "1.077" "1.196" "0.968" "0.894" "194.3" "225.5" "221.9" "247.7" "196.3" "215.4" "209.3" "232.4" "188.1" "173.6" "" "" "" "" "" "" "" "" "" "" "174.7" "182.5" "200.7" "241.8" "162.0" "215.4" "156.8" "205.3" "168.3" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2174498408520760419" "False" "High" "IsMasterProtein" "Q02241" "Kinesin-like protein KIF23 OS=Homo sapiens OX=9606 GN=KIF23 PE=1 SV=3" "0.000" "False" "14.730" "6" "5" "5" "5" "960" "110.0" "8.51" "12.16" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf16540" "9493" "ENSG00000137807" "KIF23" "B4E1K0; hsa:9493; Q02241; Q8WVP0" "Pleural mesothelioma" "MHC class II antigen presentation; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins; Mitotic Telophase/Cytokinesis" "5" "0" "1.015" "1.236" "1.029" "1.139" "1.184" "1.204" "1.030" "1.190" "1.472" "232.7" "236.1" "287.7" "239.5" "265.1" "275.4" "280.1" "239.7" "277.0" "342.5" "" "" "" "" "" "" "" "" "" "" "209.2" "191.0" "260.2" "233.8" "218.7" "275.4" "209.8" "211.7" "247.9" "122.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8617908927917494365" "False" "High" "IsMasterProtein" "O14639" "Actin-binding LIM protein 1 OS=Homo sapiens OX=9606 GN=ABLIM1 PE=1 SV=3" "0.000" "False" "14.718" "6" "5" "5" "5" "778" "87.6" "8.59" "16.91" "5" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf02209, Pf16182" "3983" "ENSG00000099204" "ABLIM1" "A6NI16; A6NJ06; A8MXA9; B3KVH2; hsa:3983; O14639; Q15039; Q5JVV1; Q5JVV2; Q5T6N2; Q5T6N3; Q5T6N5; Q68CQ9; Q9BUP1" "Male infertility" "DCC mediated attractive signaling" "2" "0" "0.926" "0.958" "0.916" "0.987" "0.928" "1.030" "0.999" "0.949" "0.905" "555.6" "514.6" "532.1" "509.0" "548.3" "515.9" "572.6" "555.1" "527.4" "502.8" "" "" "" "" "" "" "" "" "" "" "499.6" "416.4" "481.3" "496.9" "452.5" "515.9" "428.7" "490.3" "471.9" "179.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3125031583536319160" "False" "High" "IsMasterProtein" "P05204" "Non-histone chromosomal protein HMG-17 OS=Homo sapiens OX=9606 GN=HMGN2 PE=1 SV=3" "0.000" "False" "14.697" "29" "3" "7" "3" "90" "9.4" "9.99" "21.13" "3" "cell organization and biogenesis;stress response;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "3151" "ENSG00000198830" "HMGN2" "hsa:3151; P05204; Q0VGD5; Q6FGI5; Q96C64" "" "" "0" "0" "1.155" "1.065" "0.999" "0.883" "0.848" "0.599" "1.394" "0.955" "0.686" "734.4" "848.3" "782.0" "733.7" "648.7" "622.7" "440.1" "1023.6" "701.6" "503.6" "" "" "" "" "" "" "" "" "" "" "660.3" "686.4" "707.4" "716.2" "535.3" "622.7" "329.5" "904.1" "627.8" "179.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469585503029869905" "False" "High" "IsMasterProtein" "Q96PU5" "E3 ubiquitin-protein ligase NEDD4-like OS=Homo sapiens OX=9606 GN=NEDD4L PE=1 SV=2" "0.000" "False" "14.668" "6" "6" "6" "5" "975" "111.9" "5.82" "17.15" "6" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "23327" "ENSG00000049759" "NEDD4L" "hsa:23327; O43165; Q3LSM7; Q7Z5F1; Q7Z5F2; Q7Z5N3; Q8N5A7; Q8WUU9; Q96PU5; Q9BW58; Q9H2W4; Q9NT88" "TGF-beta signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; Budding and maturation of HIV virion; Stimuli-sensing channels; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "6" "0" "1.002" "1.020" "1.032" "1.000" "0.958" "1.138" "1.119" "1.048" "1.416" "259.8" "260.2" "265.0" "268.0" "259.7" "248.8" "295.6" "290.8" "272.2" "367.8" "" "" "" "" "" "" "" "" "" "" "233.5" "210.6" "239.7" "261.6" "214.3" "248.8" "221.3" "256.8" "243.6" "131.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7850572796846009162" "False" "High" "IsMasterProtein" "P52435" "DNA-directed RNA polymerase II subunit RPB11-a OS=Homo sapiens OX=9606 GN=POLR2J PE=1 SV=1" "0.000" "False" "14.620" "24" "3" "4" "3" "117" "13.3" "5.86" "14.95" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "5439" "ENSG00000005075" "POLR2J" "A5D6V8; hsa:5439; O43375; P52435" "Pyrimidine metabolism; Eukaryotic transcription initiation" "RNA polymerase II transcribes snRNA genes; Transcriptional regulation by small RNAs; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Inhibition of DNA recombination at telomere; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; mRNA Splicing - Major Pathway; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM" "43" "0" "0.892" "0.830" "0.999" "0.904" "0.852" "0.953" "0.952" "0.975" "1.129" "659.0" "587.7" "547.0" "658.2" "595.5" "561.5" "628.3" "627.5" "642.4" "743.8" "" "" "" "" "" "" "" "" "" "" "592.5" "475.6" "494.8" "642.5" "491.4" "561.5" "470.5" "554.2" "574.8" "265.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2389854899245022230" "False" "High" "IsMasterProtein" "A6NDU8" "RAB7A-interacting MON1-CCZ1 complex subunit 1 OS=Homo sapiens OX=9606 GN=RIMOC1 PE=1 SV=1" "0.000" "False" "14.603" "22" "4" "6" "4" "294" "33.6" "5.26" "28.91" "4" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus" "" "Pf17716" "285636" "ENSG00000205765" "RIMOC1" "A2RRM9; A6NDU8; hsa:285636" "" "" "0" "0" "1.112" "1.005" "0.965" "1.220" "1.104" "1.200" "1.058" "1.182" "1.226" "313.9" "349.0" "315.4" "302.9" "382.9" "346.7" "376.5" "331.9" "370.8" "384.9" "" "" "" "" "" "" "" "" "" "" "282.2" "282.4" "285.3" "295.7" "316.0" "346.7" "282.0" "293.2" "331.8" "137.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7521593605618506386" "False" "High" "IsMasterProtein" "Q02556" "Interferon regulatory factor 8 OS=Homo sapiens OX=9606 GN=IRF8 PE=1 SV=2" "0.000" "False" "14.598" "9" "4" "5" "4" "426" "48.3" "6.77" "18.94" "4" "other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3394" "ENSG00000140968" "IRF8" "A0AV82; hsa:3394; Q02556" "Vitamin D receptor pathway; Development of pulmonary dendritic cells and macrophage subsets; Extrafollicular and follicular B cell activation by SARS-CoV-2; 2q37 copy number variation syndrome; Type II interferon signaling" "Interferon gamma signaling; Interferon alpha/beta signaling" "7" "0" "0.911" "0.924" "1.000" "0.947" "0.874" "1.022" "0.933" "0.950" "2.066" "495.0" "450.8" "457.5" "494.8" "468.6" "432.6" "506.0" "461.8" "470.3" "1022.6" "" "" "" "" "" "" "" "" "" "" "445.0" "364.7" "413.8" "482.9" "386.7" "432.6" "378.9" "407.9" "420.8" "365.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3805240560895531655" "False" "High" "IsMasterProtein" "Q15532" "Protein SSXT OS=Homo sapiens OX=9606 GN=SS18 PE=1 SV=3" "0.000" "False" "14.582" "7" "3" "4" "3" "418" "45.9" "6.46" "17.93" "3" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf05030" "6760" "ENSG00000141380" "SS18" "B0YJ95; hsa:6760; Q15532; Q16404; Q4VAX1; Q9BXC6" "" "" "0" "0" "0.982" "0.912" "1.004" "0.956" "1.022" "0.958" "1.015" "0.875" "1.475" "653.2" "641.2" "595.8" "655.9" "624.4" "667.6" "625.6" "662.7" "571.3" "963.3" "" "" "" "" "" "" "" "" "" "" "587.3" "518.9" "538.9" "640.2" "515.2" "667.6" "468.5" "585.4" "511.2" "343.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011365371626777610" "False" "High" "IsMasterProtein" "P56277" "Cx9C motif-containing protein 4 OS=Homo sapiens OX=9606 GN=CMC4 PE=1 SV=1" "0.000" "False" "14.579" "59" "5" "6" "5" "68" "7.7" "8.18" "20.68" "5" "" "mitochondrion" "" "Pf08991" "100272147" "ENSG00000182712" "CMC4" "hsa:100272147; P56277; Q5HYP9" "" "Mitochondrial protein import" "1" "0" "1.044" "1.048" "0.974" "1.065" "1.052" "1.041" "1.032" "1.031" "0.792" "750.3" "783.5" "786.5" "731.0" "799.2" "789.5" "781.3" "774.3" "773.8" "594.1" "" "" "" "" "" "" "" "" "" "" "674.6" "634.0" "711.4" "713.6" "659.5" "789.5" "585.0" "683.9" "692.4" "212.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8095866348413873216" "False" "High" "IsMasterProtein" "Q8WUB8" "PHD finger protein 10 OS=Homo sapiens OX=9606 GN=PHF10 PE=1 SV=3" "0.000" "False" "14.552" "11" "4" "4" "4" "498" "56.0" "6.62" "14.63" "4" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628" "55274" "ENSG00000130024" "PHF10" "hsa:55274; Q2YDA3; Q53HG8; Q8WUB8; Q9BXD2; Q9NV26" "" "" "0" "0" "0.961" "1.101" "0.915" "1.176" "1.090" "1.143" "1.085" "1.091" "1.508" "318.3" "305.8" "350.5" "291.2" "374.2" "346.9" "363.7" "345.5" "347.2" "480.0" "" "" "" "" "" "" "" "" "" "" "286.2" "247.5" "317.0" "284.2" "308.8" "346.9" "272.3" "305.2" "310.7" "171.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2424139350801194209" "False" "High" "IsMasterProtein" "Q9NRG0" "Chromatin accessibility complex protein 1 OS=Homo sapiens OX=9606 GN=CHRAC1 PE=1 SV=1" "0.000" "False" "14.540" "31" "3" "5" "3" "131" "14.7" "5.10" "21.44" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "54108" "ENSG00000104472" "CHRAC1" "hsa:54108; Q9NRG0" "Acute viral myocarditis" "" "1" "0" "1.005" "0.894" "0.966" "1.048" "0.966" "1.086" "1.045" "1.018" "0.879" "582.8" "585.8" "520.8" "563.2" "610.9" "562.9" "632.9" "608.9" "593.1" "512.0" "" "" "" "" "" "" "" "" "" "" "524.0" "474.0" "471.1" "549.7" "504.1" "562.9" "473.9" "537.8" "530.7" "182.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2189379826665428433" "False" "High" "IsMasterProtein" "Q9UMY1" "U3 small nucleolar RNA-associated protein NOL7 OS=Homo sapiens OX=9606 GN=NOL7 PE=1 SV=2" "0.000" "False" "14.521" "13" "4" "7" "4" "257" "29.4" "9.67" "22.54" "4" "other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf08157" "51406" "ENSG00000225921" "NOL7" "hsa:51406; Q5T297; Q9UMY1; Q9Y3U7" "" "" "0" "0" "0.991" "0.708" "0.989" "0.996" "0.733" "1.014" "1.012" "0.732" "0.582" "851.3" "843.4" "603.1" "841.6" "848.3" "624.0" "863.5" "861.2" "622.8" "495.4" "" "" "" "" "" "" "" "" "" "" "765.4" "682.4" "545.5" "821.5" "700.0" "624.0" "646.5" "760.7" "557.3" "176.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3536014580655726636" "False" "High" "IsMasterProtein" "P98170" "E3 ubiquitin-protein ligase XIAP OS=Homo sapiens OX=9606 GN=XIAP PE=1 SV=2" "0.000" "False" "14.514" "8" "4" "4" "4" "497" "56.6" "6.65" "16.07" "4" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00653, Pf13920, Pf21290" "331" "ENSG00000101966" "XIAP" "D3DTF2; hsa:331; P98170; Q9NQ14" "Nucleotide-binding oligomerization domain (NOD) pathway; Apoptosis modulation and signaling; Apoptosis; Focal adhesion; Copper homeostasis; NO/cGMP/PKG mediated neuroprotection; Complement system in neuronal development and plasticity" "TNFR1-induced NF-kappa-B signaling pathway; Regulation of PTEN stability and activity; Deactivation of the beta-catenin transactivating complex; Regulation of necroptotic cell death; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; Regulation of TNFR1 signaling; TNFR1-induced proapoptotic signaling; Regulation of PTEN localization" "20" "0" "0.962" "1.124" "0.937" "1.031" "1.059" "1.003" "1.034" "1.112" "1.533" "421.0" "404.8" "473.1" "394.3" "434.0" "445.9" "422.2" "435.1" "468.2" "645.2" "" "" "" "" "" "" "" "" "" "" "378.5" "327.6" "427.9" "384.9" "358.2" "445.9" "316.2" "384.3" "418.9" "230.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2715206749087144500" "False" "High" "IsMasterProtein" "Q8WUR7" "UPF0235 protein C15orf40 OS=Homo sapiens OX=9606 GN=C15orf40 PE=1 SV=2" "0.000" "False" "14.498" "24" "3" "4" "3" "153" "16.3" "9.83" "18.98" "3" "" "other cell component" "" "Pf02594" "123207" "ENSG00000169609" "C15orf40" "A6NIC9; B2R5E7; F5GX92; F8WD31; G5EA00; hsa:123207; Q8WUR7" "15q25 copy number variation" "" "1" "0" "0.883" "1.069" "0.996" "1.082" "0.986" "1.006" "1.129" "1.141" "0.816" "264.3" "233.5" "282.5" "263.4" "285.9" "260.6" "265.9" "298.4" "301.7" "215.6" "" "" "" "" "" "" "" "" "" "" "237.7" "189.0" "255.5" "257.1" "236.0" "260.6" "199.1" "263.5" "269.9" "77.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6000200469823771153" "False" "High" "IsMasterProtein" "P63272" "Transcription elongation factor SPT4 OS=Homo sapiens OX=9606 GN=SUPT4H1 PE=1 SV=1" "0.000" "False" "14.495" "31" "3" "4" "3" "117" "13.2" "8.06" "15.64" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf06093" "6827" "ENSG00000213246" "SUPT4H1" "B2R4X8; D3DTZ4; hsa:6827; P63272; Q16550; Q62387; Q6ZP89" "Initiation of transcription and translation elongation at the HIV-1 LTR" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes" "16" "0" "0.896" "1.064" "1.034" "0.943" "1.218" "1.025" "1.045" "1.075" "1.021" "405.0" "362.9" "431.0" "418.7" "381.9" "493.4" "415.1" "423.2" "435.2" "413.3" "" "" "" "" "" "" "" "" "" "" "364.1" "293.7" "389.9" "408.7" "315.2" "493.4" "310.8" "373.8" "389.4" "147.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5858537743821975597" "False" "High" "IsMasterProtein" "O75843" "AP-1 complex subunit gamma-like 2 OS=Homo sapiens OX=9606 GN=AP1G2 PE=1 SV=1" "0.000" "False" "14.472" "5" "4" "5" "4" "785" "87.1" "6.55" "14.81" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf02883" "8906" "ENSG00000213983" "AP1G2" "D3DS51; hsa:8906; O75504; O75843" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.011" "0.991" "1.044" "1.120" "1.061" "1.162" "0.852" "0.997" "2.669" "231.3" "233.9" "229.1" "241.5" "259.0" "245.4" "268.9" "197.2" "230.7" "617.3" "" "" "" "" "" "" "" "" "" "" "208.0" "189.2" "207.3" "235.8" "213.8" "245.4" "201.3" "174.2" "206.4" "220.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1100964520603987926" "False" "High" "IsMasterProtein" "Q13825" "Methylglutaconyl-CoA hydratase, mitochondrial OS=Homo sapiens OX=9606 GN=AUH PE=1 SV=1" "0.000" "False" "14.470" "12" "4" "4" "4" "339" "35.6" "9.48" "14.33" "4" "other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00378" "549" "ENSG00000148090" "AUH" "B1ALV7; B1ALV8; hsa:549; Q13825; Q8WUE4" "Amino acid metabolism" "Branched-chain amino acid catabolism" "2" "0" "1.083" "1.015" "1.089" "1.091" "0.998" "1.187" "1.114" "0.952" "0.997" "223.8" "242.5" "227.1" "243.7" "244.3" "223.3" "265.7" "249.4" "213.0" "223.1" "" "" "" "" "" "" "" "" "" "" "201.3" "196.2" "205.4" "237.9" "201.6" "223.3" "198.9" "220.3" "190.6" "79.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2600718552513118007" "False" "High" "IsMasterProtein" "Q86VR2" "Reticulophagy regulator 3 OS=Homo sapiens OX=9606 GN=RETREG3 PE=1 SV=1" "0.000" "False" "14.459" "6" "2" "4" "2" "466" "51.4" "4.97" "16.49" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "" "162427" "ENSG00000141699" "RETREG3" "B3KR75; hsa:162427; Q86VR2" "" "" "0" "0" "1.053" "1.048" "0.851" "0.971" "1.043" "1.245" "0.991" "1.055" "1.052" "24.7" "26.0" "25.9" "21.0" "24.0" "25.8" "30.7" "24.5" "26.1" "26.0" "" "" "" "" "" "" "" "" "" "" "22.2" "21.0" "23.4" "20.5" "19.8" "25.8" "23.0" "21.6" "23.3" "9.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5575516958920561508" "False" "High" "IsMasterProtein" "Q9H1Y0" "Autophagy protein 5 OS=Homo sapiens OX=9606 GN=ATG5 PE=1 SV=2" "0.000" "False" "14.439" "15" "3" "4" "3" "275" "32.4" "5.77" "12.72" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04106, Pf20637, Pf20638" "9474" "ENSG00000057663" "ATG5" "hsa:9474; O60875; Q5JVR2; Q68DI4; Q9H1Y0; Q9H2B8; Q9HCZ7" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Ferroptosis; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Negative regulators of DDX58/IFIH1 signaling; Macroautophagy; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "13" "0" "0.954" "0.984" "0.995" "0.954" "1.032" "0.991" "1.019" "0.947" "1.190" "410.5" "391.6" "404.1" "408.6" "391.8" "423.6" "407.0" "418.5" "388.8" "488.7" "" "" "" "" "" "" "" "" "" "" "369.1" "316.9" "365.5" "398.8" "323.3" "423.6" "304.8" "369.6" "347.9" "174.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7415946790012265046" "False" "High" "IsMasterProtein" "O75586" "Mediator of RNA polymerase II transcription subunit 6 OS=Homo sapiens OX=9606 GN=MED6 PE=1 SV=2" "0.000" "False" "14.417" "14" "4" "4" "4" "246" "28.4" "8.62" "14.26" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04934" "10001" "ENSG00000133997" "MED6" "B4DU17; B4E2P0; hsa:10001; O15401; O75586; Q53FE3; Q53HJ3; Q6FHQ4; Q9BTH1; Q9UHL1" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "0.948" "0.996" "0.908" "0.993" "0.993" "1.042" "0.907" "0.828" "1.063" "433.4" "410.7" "431.7" "393.3" "430.3" "430.4" "451.5" "393.1" "358.8" "460.5" "" "" "" "" "" "" "" "" "" "" "389.6" "332.3" "390.5" "383.9" "355.1" "430.4" "338.0" "347.2" "321.1" "164.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7453155325725910333" "False" "High" "IsMasterProtein" "Q9Y2K2" "Serine/threonine-protein kinase SIK3 OS=Homo sapiens OX=9606 GN=SIK3 PE=1 SV=4" "0.000" "False" "14.416" "3" "5" "8" "5" "1321" "144.8" "6.79" "19.72" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069" "23387" "ENSG00000160584" "SIK3" "A1A5A8; H0Y494; hsa:23387; J3KPC8; Q59FY2; Q5M9N1; Q6P3R6; Q8IYM8; Q9HA50; Q9Y2K2" "" "" "0" "0" "1.064" "1.125" "1.014" "0.984" "1.100" "1.169" "0.969" "1.020" "0.910" "213.8" "227.5" "240.6" "216.8" "210.4" "235.3" "250.0" "207.2" "218.2" "194.6" "" "" "" "" "" "" "" "" "" "" "192.2" "184.1" "217.6" "211.7" "173.6" "235.3" "187.2" "183.0" "195.2" "69.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8760607610450426056" "False" "High" "IsMasterProtein" "P35251" "Replication factor C subunit 1 OS=Homo sapiens OX=9606 GN=RFC1 PE=1 SV=4" "0.000" "False" "14.414" "4" "5" "6" "5" "1148" "128.2" "9.36" "18.10" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf00533, Pf08519" "5981" "ENSG00000035928" "RFC1" "A8K6E7; hsa:5981; P35251; Q5XKF5; Q6PKU0; Q86V41; Q86V46" "miRNA regulation of DNA damage response; DNA replication; Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair; DNA damage response" "PCNA-Dependent Long Patch Base Excision Repair; Termination of translesion DNA synthesis; HDR through Homologous Recombination (HRR); Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Polymerase switching on the C-strand of the telomere; Polymerase switching; Translesion Synthesis by POLH; Gap-filling DNA repair synthesis and ligation in GG-NER" "22" "0" "0.893" "0.980" "0.870" "0.953" "1.032" "0.920" "0.862" "0.843" "1.290" "95.8" "85.6" "94.0" "83.4" "91.4" "98.9" "88.2" "82.6" "80.8" "123.6" "" "" "" "" "" "" "" "" "" "" "86.2" "69.3" "85.0" "81.4" "75.4" "98.9" "66.0" "73.0" "72.3" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-911938199932515837" "False" "High" "IsMasterProtein" "Q9NZQ3" "NCK-interacting protein with SH3 domain OS=Homo sapiens OX=9606 GN=NCKIPSD PE=1 SV=1" "0.000" "False" "14.391" "8" "6" "6" "6" "722" "78.9" "6.38" "14.28" "6" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;other molecular function" "Pf00018, Pf09431" "51517" "ENSG00000213672" "NCKIPSD" "B4DFL5; hsa:51517; Q6GU34; Q6SPF3; Q8TC10; Q9NZQ3; Q9UGM8" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs" "3" "0" "1.246" "1.189" "1.156" "1.244" "1.227" "1.309" "1.161" "1.386" "2.310" "102.2" "127.4" "121.6" "118.2" "127.2" "125.4" "133.9" "118.7" "141.7" "236.2" "" "" "" "" "" "" "" "" "" "" "91.9" "103.1" "110.0" "115.4" "104.9" "125.4" "100.2" "104.9" "126.8" "84.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787657634019778386" "False" "High" "IsMasterProtein" "Q2TAA2" "Isoamyl acetate-hydrolyzing esterase 1 homolog OS=Homo sapiens OX=9606 GN=IAH1 PE=1 SV=1" "0.000" "False" "14.356" "18" "4" "8" "4" "248" "27.6" "5.30" "25.20" "4" "other metabolic processes" "" "other molecular function" "Pf00657" "285148" "ENSG00000134330" "IAH1" "B4DMV3; hsa:285148; Q2TAA2" "" "" "0" "0" "1.048" "1.048" "1.085" "1.118" "1.070" "1.051" "1.076" "1.099" "0.895" "396.7" "415.5" "415.9" "430.5" "443.4" "424.2" "416.8" "427.0" "436.0" "354.9" "" "" "" "" "" "" "" "" "" "" "356.6" "336.2" "376.2" "420.3" "365.9" "424.2" "312.1" "377.1" "390.1" "126.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7820543804174258540" "False" "High" "IsMasterProtein" "P00374" "Dihydrofolate reductase OS=Homo sapiens OX=9606 GN=DHFR PE=1 SV=2" "0.000" "False" "14.347" "22" "5" "9" "5" "187" "21.4" "7.42" "21.86" "5" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00186" "1719" "ENSG00000228716" "DHFR" "B4DDD2; hsa:1719; P00374; Q14130; Q6IRW8" "Fluoropyrimidine activity; Folate metabolism; One-carbon metabolism; Retinoblastoma gene in cancer; Trans-sulfuration, one-carbon metabolism and related pathways; Ethanol effects on histone modifications" "G1/S-Specific Transcription; Metabolism of folate and pterines; Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "9" "0" "1.009" "0.960" "0.900" "0.900" "1.030" "0.975" "0.889" "1.115" "2.521" "355.3" "358.7" "341.1" "319.6" "319.8" "366.1" "346.4" "316.0" "396.2" "895.7" "" "" "" "" "" "" "" "" "" "" "319.5" "290.2" "308.5" "312.0" "263.9" "366.1" "259.4" "279.1" "354.6" "319.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3813799245873050122" "False" "High" "IsMasterProtein" "Q96L91" "E1A-binding protein p400 OS=Homo sapiens OX=9606 GN=EP400 PE=1 SV=4" "0.000" "False" "14.341" "1" "4" "6" "4" "3159" "343.3" "9.19" "16.95" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529, Pf15790" "57634" "ENSG00000183495" "EP400" "hsa:57634; O15411; Q6P2F5; Q8N8Q7; Q8NE05; Q96JK7; Q96L91; Q9P230" "HDAC6 interactions in the central nervous system" "Formation of Senescence-Associated Heterochromatin Foci (SAHF); HATs acetylate histones" "4" "0" "0.952" "1.067" "0.996" "0.957" "1.006" "1.078" "0.950" "0.938" "1.102" "466.6" "444.2" "497.8" "464.7" "446.5" "469.2" "502.8" "443.1" "437.9" "514.1" "" "" "" "" "" "" "" "" "" "" "419.5" "359.5" "450.3" "453.6" "368.5" "469.2" "376.5" "391.4" "391.8" "183.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "592112739915171791" "False" "High" "IsMasterProtein" "Q8NCG7" "Diacylglycerol lipase-beta OS=Homo sapiens OX=9606 GN=DAGLB PE=1 SV=2" "0.000" "False" "14.334" "8" "4" "5" "4" "672" "73.7" "6.55" "18.15" "4" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf01764" "221955" "ENSG00000164535" "DAGLB" "A4D2P3; B3KV90; B4DQU0; hsa:221955; Q6PIX3; Q8N2N2; Q8N9S1; Q8NCG7; Q8TED3; Q8WXE6" "Cannabinoid receptor signaling; ADHD and autism (ASD) linked metabolic pathways and SNP" "Arachidonate production from DAG" "3" "0" "1.112" "1.064" "1.070" "1.229" "1.080" "1.155" "1.052" "1.181" "1.269" "147.9" "164.4" "157.3" "158.2" "181.7" "159.7" "170.8" "155.6" "174.6" "187.7" "" "" "" "" "" "" "" "" "" "" "133.0" "133.0" "142.3" "154.5" "149.9" "159.7" "127.9" "137.5" "156.2" "67.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3703495334451703375" "False" "High" "IsMasterProtein" "O94782" "Ubiquitin carboxyl-terminal hydrolase 1 OS=Homo sapiens OX=9606 GN=USP1 PE=1 SV=1" "0.000" "False" "14.329" "8" "4" "4" "4" "785" "88.2" "5.45" "13.70" "4" "protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00443" "7398" "ENSG00000162607" "USP1" "A0PJ95; D3DQ57; hsa:7398; O94782; Q05BX7; Q59H66; Q9UFR0; Q9UNJ3" "miR-517 relationship with ARCN1 and USP1; DNA repair pathways, full network" "Fanconi Anemia Pathway; Recognition of DNA damage by PCNA-containing replication complex" "4" "0" "0.954" "0.927" "0.921" "0.891" "1.046" "0.983" "0.834" "0.852" "1.665" "149.2" "142.3" "138.3" "137.3" "132.9" "156.0" "146.7" "124.4" "127.0" "248.4" "" "" "" "" "" "" "" "" "" "" "134.1" "115.2" "125.1" "134.0" "109.7" "156.0" "109.8" "109.9" "113.7" "88.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4643868144451564503" "False" "High" "IsMasterProtein" "P41567" "Eukaryotic translation initiation factor 1 OS=Homo sapiens OX=9606 GN=EIF1 PE=1 SV=1" "0.000" "False" "14.325" "27" "2" "12" "2" "113" "12.7" "7.44" "47.68" "2" "protein metabolism;other metabolic processes;other biological processes" "translational apparatus;nucleus;other cell component" "translation activity;nucleic acid binding activity" "Pf01253" "10209" "ENSG00000173812" "EIF1" "hsa:10209; P41567; Q9UNQ9" "Translation factors; nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell" "" "2" "0" "0.887" "1.025" "0.945" "1.030" "0.965" "0.964" "0.960" "0.997" "0.744" "658.2" "583.5" "674.7" "622.2" "677.9" "635.2" "634.7" "631.6" "656.3" "489.8" "" "" "" "" "" "" "" "" "" "" "591.7" "472.2" "610.3" "607.3" "559.4" "635.2" "475.2" "557.9" "587.2" "174.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-431742904065760490" "False" "High" "IsMasterProtein" "O75955" "Flotillin-1 OS=Homo sapiens OX=9606 GN=FLOT1 PE=1 SV=3" "0.000" "False" "14.313" "10" "4" "4" "4" "427" "47.3" "7.49" "15.92" "4" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01145" "10211" "ENSG00000137312; ENSG00000206379; ENSG00000206480; ENSG00000230143; ENSG00000232280" "FLOT1" "B4DVY7; hsa:10211; O75955; Q969J8; Q9UHW1; Q9UNV8" "Angiopoietin-like protein 8 regulatory pathway; Insulin signaling" "RHOC GTPase cycle; RHOA GTPase cycle; RHOB GTPase cycle; Regulation of necroptotic cell death; Synaptic adhesion-like molecules" "8" "0" "1.085" "1.186" "1.034" "1.214" "1.293" "1.210" "1.067" "1.230" "1.716" "203.5" "220.8" "241.5" "210.3" "247.2" "263.2" "246.2" "217.1" "250.4" "349.2" "" "" "" "" "" "" "" "" "" "" "183.0" "178.6" "218.4" "205.3" "204.0" "263.2" "184.3" "191.7" "224.1" "124.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2819385337701029723" "False" "High" "IsMasterProtein" "Q9UHB9" "Signal recognition particle subunit SRP68 OS=Homo sapiens OX=9606 GN=SRP68 PE=1 SV=2" "0.000" "False" "14.294" "9" "4" "5" "4" "627" "70.7" "8.56" "13.70" "4" "other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16969" "6730" "ENSG00000167881" "SRP68" "B3KUU5; B3KWY7; G3V1U4; hsa:6730; Q8NCJ4; Q8WUK2; Q9UHB9" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.923" "0.897" "0.856" "0.918" "0.928" "0.919" "0.888" "0.920" "0.882" "197.1" "181.8" "176.7" "168.6" "181.0" "182.9" "181.0" "175.0" "181.4" "173.8" "" "" "" "" "" "" "" "" "" "" "177.2" "147.1" "159.8" "164.6" "149.4" "182.9" "135.5" "154.6" "162.3" "62.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4711038865420362592" "False" "High" "IsMasterProtein" "Q9BRV8" "Suppressor of IKBKE 1 OS=Homo sapiens OX=9606 GN=SIKE1 PE=1 SV=1" "0.000" "False" "14.287" "18" "3" "4" "3" "207" "23.7" "5.21" "15.58" "3" "" "cytosol" "other molecular function" "Pf05769" "80143" "ENSG00000052723" "SIKE1" "hsa:80143; Q5TEZ7; Q5TEZ9; Q68DZ4; Q9BRV8; Q9H778" "Novel intracellular components of RIG-I-like receptor pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; TRAF3-dependent IRF activation pathway; TRAF6 mediated IRF7 activation" "5" "0" "0.948" "1.110" "0.927" "1.003" "0.973" "0.924" "0.948" "0.939" "0.868" "260.1" "246.7" "288.6" "241.2" "260.9" "253.0" "240.3" "246.6" "244.2" "225.7" "" "" "" "" "" "" "" "" "" "" "233.9" "199.6" "261.0" "235.4" "215.3" "253.0" "179.9" "217.8" "218.6" "80.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7909778503156322818" "False" "High" "IsMasterProtein" "Q96J02" "E3 ubiquitin-protein ligase Itchy homolog OS=Homo sapiens OX=9606 GN=ITCH PE=1 SV=2" "0.000" "False" "14.263" "6" "6" "6" "4" "903" "102.7" "6.30" "17.14" "6" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168, Pf00397, Pf00632" "83737" "ENSG00000078747" "ITCH" "A6NEW4; B4E234; E1P5P3; F5H217; hsa:83737; O43584; Q5QP37; Q5TEL0; Q96F66; Q96J02; Q9BY75; Q9H451; Q9H4U5" "TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; EGF/EGFR signaling pathway; Nonalcoholic fatty liver disease; 10q11.21q11.23 copy number variation syndrome; Notch signaling pathway" "Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Degradation of GLI1 by the proteasome; Hedgehog 'on' state; Activated NOTCH1 Transmits Signal to the Nucleus; Regulation of necroptotic cell death; NOD1/2 Signaling Pathway; Negative regulators of DDX58/IFIH1 signaling; SARS-CoV-1 activates/modulates innate immune responses; Downregulation of ERBB4 signaling" "16" "0" "0.979" "1.006" "0.969" "0.998" "0.992" "0.992" "1.051" "1.011" "1.547" "132.0" "129.2" "132.8" "127.9" "131.8" "130.9" "131.0" "138.8" "133.5" "204.2" "" "" "" "" "" "" "" "" "" "" "118.7" "104.5" "120.1" "124.8" "108.8" "130.9" "98.1" "122.6" "119.4" "72.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5327705833801287144" "False" "High" "IsMasterProtein" "Q96EP0" "E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens OX=9606 GN=RNF31 PE=1 SV=1" "0.000" "False" "14.260" "5" "5" "5" "5" "1072" "119.6" "6.57" "13.55" "5" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf01485, Pf09409, Pf16678, Pf18091, Pf18486" "55072" "ENSG00000092098; ENSG00000285152" "RNF31" "A0A962; Q86VI2; Q8TEI0; Q96EP0; Q96GB4; Q96NF1; Q9H5F1; Q9NWD2" "" "Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "3" "0" "1.068" "1.171" "1.089" "1.063" "1.091" "1.012" "1.036" "1.120" "1.405" "301.8" "322.5" "353.4" "328.8" "320.8" "329.2" "305.4" "312.8" "337.9" "424.2" "" "" "" "" "" "" "" "" "" "" "271.4" "260.9" "319.6" "320.9" "264.7" "329.2" "228.7" "276.3" "302.4" "151.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8712581138028706155" "False" "High" "IsMasterProtein" "Cont_P02081" "Hemoglobin fetal subunit beta OS=Bos taurus OX=9913 PE=1 SV=1" "0.000" "True" "14.256" "28" "4" "5" "3" "145" "15.8" "7.03" "17.21" "4" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "104983812; 109569915; 109569938; 511735" "ENSBIXG00000000751; ENSBTAG00000038748" "LOC104983812; LOC109569915; LOC113905586" "A0A4W2CHH0; A0A6P3GXP4; A0A6P5D2L1; bbis:104983812; biu:109569915; biu:109569938; bta:511735; P02081; Q3SX09" "" "" "0" "1" "0.955" "0.903" "1.157" "1.384" "0.859" "1.102" "1.276" "1.004" "1.304" "157.2" "150.1" "141.9" "181.9" "217.5" "135.0" "173.2" "200.6" "157.9" "205.0" "" "" "" "" "" "" "" "" "" "" "141.4" "121.4" "128.4" "177.6" "179.5" "135.0" "129.7" "177.2" "141.2" "73.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8312057505130700222" "False" "High" "IsMasterProtein" "P06865" "Beta-hexosaminidase subunit alpha OS=Homo sapiens OX=9606 GN=HEXA PE=1 SV=2" "0.000" "False" "14.241" "10" "5" "5" "4" "529" "60.7" "5.16" "14.67" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3073" "ENSG00000213614" "HEXA" "B4DKE7; E7ENH7; hsa:3073; P06865; Q53HS8; Q6AI32" "Degradation pathway of sphingolipids, including diseases; Glycosaminoglycan degradation" "CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXA causes GM2G1" "7" "1" "1.029" "1.000" "1.021" "1.168" "1.049" "1.021" "1.029" "1.130" "0.995" "286.9" "295.2" "286.9" "292.9" "335.1" "301.0" "292.8" "295.3" "324.1" "285.4" "" "" "" "" "" "" "" "" "" "" "257.9" "238.9" "259.5" "285.9" "276.5" "301.0" "219.3" "260.8" "290.0" "101.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7529838149184307642" "False" "High" "IsMasterProtein" "P04066" "Tissue alpha-L-fucosidase OS=Homo sapiens OX=9606 GN=FUCA1 PE=1 SV=4" "0.000" "False" "14.236" "10" "5" "6" "5" "466" "53.7" "6.84" "19.40" "5" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01120, Pf16757" "2517" "ENSG00000179163" "FUCA1" "B2RBG3; hsa:2517; P04066; Q14334; Q14335; Q3LID0; Q8NAC2" "p53 transcriptional gene network" "Neutrophil degranulation; Reactions specific to the complex N-glycan synthesis pathway" "3" "0" "0.997" "1.062" "0.954" "1.030" "1.005" "1.062" "1.038" "1.153" "1.053" "373.6" "372.6" "397.0" "356.3" "384.9" "375.4" "396.8" "388.0" "430.7" "393.4" "" "" "" "" "" "" "" "" "" "" "335.9" "301.5" "359.1" "347.8" "317.7" "375.4" "297.1" "342.7" "385.4" "140.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4664258247594329003" "False" "High" "IsMasterProtein" "Q9H9B1" "Histone-lysine N-methyltransferase EHMT1 OS=Homo sapiens OX=9606 GN=EHMT1 PE=1 SV=4" "0.000" "False" "14.220" "5" "4" "4" "3" "1298" "141.4" "5.76" "13.69" "4" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00856, Pf05033, Pf12796, Pf21533" "79813" "ENSG00000181090" "EHMT1" "B1AQ58; B1AQ59; hsa:79813; Q86X08; Q8TCN7; Q96F53; Q96JF1; Q96KH4; Q9H9B1" "Histone modifications; MTHFR deficiency; Kleefstra syndrome" "Senescence-Associated Secretory Phenotype (SASP); Regulation of TP53 Activity through Methylation; Transcriptional Regulation by E2F6; Transcriptional Regulation by VENTX; PKMTs methylate histone lysines" "8" "1" "0.962" "0.967" "0.901" "1.068" "0.879" "0.995" "0.940" "0.883" "1.516" "231.0" "222.2" "223.4" "208.1" "246.7" "203.0" "229.8" "217.2" "204.1" "350.1" "" "" "" "" "" "" "" "" "" "" "207.7" "179.8" "202.1" "203.2" "203.6" "203.0" "172.1" "191.9" "182.6" "125.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245887775356859101" "False" "High" "IsMasterProtein" "Q8N0Z6" "Tetratricopeptide repeat protein 5 OS=Homo sapiens OX=9606 GN=TTC5 PE=1 SV=2" "0.000" "False" "14.208" "10" "4" "4" "4" "440" "48.9" "6.48" "14.34" "4" "DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16669" "91875" "ENSG00000136319; ENSG00000291781" "TTC5" "A8MQ18; hsa:91875; Q8N0Z6; Q96HF9" "" "Regulation of TP53 Activity through Methylation" "1" "0" "0.929" "0.802" "0.737" "1.154" "0.984" "0.850" "0.772" "0.775" "3.219" "114.0" "105.9" "91.4" "84.0" "131.6" "112.1" "96.9" "88.1" "88.3" "366.9" "" "" "" "" "" "" "" "" "" "" "102.5" "85.7" "82.7" "82.0" "108.6" "112.1" "72.5" "77.8" "79.0" "131.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6221912277285666984" "False" "High" "IsMasterProtein" "Q5TC12" "ATP synthase mitochondrial F1 complex assembly factor 1 OS=Homo sapiens OX=9606 GN=ATPAF1 PE=1 SV=1" "0.000" "False" "14.175" "15" "4" "5" "4" "328" "36.4" "7.96" "13.54" "4" "cell organization and biogenesis" "mitochondrion" "" "Pf06644" "64756" "ENSG00000123472" "ATPAF1" "B1AQW7; B7Z7D6; B7Z7I6; hsa:64756; Q5TC12; Q9H6E3" "7q11.23 copy number variation syndrome" "" "1" "0" "1.013" "1.011" "1.016" "1.054" "1.023" "1.061" "1.010" "1.073" "1.132" "444.6" "450.4" "449.5" "451.6" "468.8" "454.9" "471.8" "449.1" "477.1" "503.3" "" "" "" "" "" "" "" "" "" "" "399.7" "364.4" "406.6" "440.8" "386.8" "454.9" "353.3" "396.7" "426.9" "179.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1562013219529803649" "False" "High" "IsMasterProtein" "P15391" "B-lymphocyte antigen CD19 OS=Homo sapiens OX=9606 GN=CD19 PE=1 SV=6" "0.000" "False" "14.166" "8" "4" "4" "4" "556" "61.1" "4.98" "16.01" "4" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "" "" "930" "ENSG00000177455" "CD19" "A0N0P9; F5H635; hsa:930; P15391; Q96S68; Q9BRD6" "B cell receptor signaling pathway; Complement system; PI3K-Akt signaling pathway; Leukocyte-intrinsic Hippo pathway functions; 16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling" "13" "0" "0.854" "0.903" "0.989" "0.932" "0.891" "0.908" "0.928" "0.921" "0.659" "393.1" "335.6" "355.0" "388.9" "366.2" "350.1" "356.8" "364.8" "362.2" "259.2" "" "" "" "" "" "" "" "" "" "" "353.4" "271.5" "321.1" "379.7" "302.2" "350.1" "267.2" "322.2" "324.1" "92.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4943929285707188175" "False" "High" "IsMasterProtein" "O60294" "tRNA wybutosine-synthesizing protein 4 OS=Homo sapiens OX=9606 GN=LCMT2 PE=1 SV=3" "0.000" "False" "14.163" "7" "4" "4" "4" "686" "75.6" "6.73" "15.14" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "other molecular function" "Pf04072" "9836" "ENSG00000168806" "LCMT2" "hsa:9836; O60294; Q4JFT6; Q96B55; Q9NR10" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.114" "1.044" "0.952" "1.196" "1.013" "1.229" "0.924" "1.094" "0.977" "216.5" "241.2" "225.9" "206.2" "259.0" "219.3" "266.0" "200.1" "236.9" "211.5" "" "" "" "" "" "" "" "" "" "" "194.6" "195.2" "204.4" "201.2" "213.7" "219.3" "199.2" "176.7" "212.0" "75.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8814237146634600983" "False" "High" "IsMasterProtein" "Q15642" "Cdc42-interacting protein 4 OS=Homo sapiens OX=9606 GN=TRIP10 PE=1 SV=3" "0.000" "False" "14.112" "8" "4" "5" "4" "601" "68.3" "5.73" "17.11" "4" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00018, Pf00611" "9322" "ENSG00000125733" "TRIP10" "B2R8A6; B7WP22; D6W645; hsa:9322; O15184; Q15642; Q53G22; Q5TZN1; Q6FI24; Q8NFL1; Q8TCY1; Q8TDX3; Q96RJ1" "Angiopoietin-like protein 8 regulatory pathway" "RHOQ GTPase cycle; Clathrin-mediated endocytosis" "3" "0" "0.961" "1.089" "0.972" "1.052" "1.101" "1.018" "0.957" "1.152" "0.987" "443.5" "426.2" "483.0" "431.2" "466.5" "488.4" "451.3" "424.4" "511.0" "437.8" "" "" "" "" "" "" "" "" "" "" "398.8" "344.8" "436.9" "420.9" "385.0" "488.4" "337.9" "374.9" "457.2" "156.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2452511729080939995" "False" "High" "IsMasterProtein" "O95159" "Zinc finger protein-like 1 OS=Homo sapiens OX=9606 GN=ZFPL1 PE=1 SV=2" "0.000" "False" "14.107" "18" "5" "5" "5" "310" "34.1" "8.07" "10.93" "5" "transport;other biological processes" "other membranes;ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "" "7542" "ENSG00000162300" "ZFPL1" "A8K7E9; hsa:7542; O14616; O95159; Q9UID0" "" "" "0" "0" "1.141" "1.054" "1.199" "1.080" "1.098" "1.171" "1.118" "0.947" "0.932" "113.8" "129.9" "120.0" "136.5" "123.0" "124.9" "133.3" "127.2" "107.8" "106.1" "" "" "" "" "" "" "" "" "" "" "102.3" "105.1" "108.5" "133.2" "101.5" "124.9" "99.8" "112.4" "96.5" "37.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8650097818779685703" "False" "High" "IsMasterProtein" "P62857" "Small ribosomal subunit protein eS28 OS=Homo sapiens OX=9606 GN=RPS28 PE=1 SV=1" "0.000" "False" "14.079" "30" "2" "17" "2" "69" "7.8" "10.70" "42.86" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01200" "6234" "ENSG00000233927" "RPS28" "hsa:6234; P25112; P62857" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Translation initiation complex formation; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.001" "0.956" "0.952" "1.077" "0.988" "1.029" "1.094" "0.910" "0.807" "1585.6" "1586.8" "1516.3" "1509.1" "1708.4" "1567.0" "1631.0" "1734.2" "1442.6" "1278.9" "" "" "" "" "" "" "" "" "" "" "1425.6" "1284.0" "1371.5" "1473.0" "1409.8" "1567.0" "1221.3" "1531.8" "1290.8" "456.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4847329680640326989" "False" "High" "IsMasterProtein" "Q8NDI1" "EH domain-binding protein 1 OS=Homo sapiens OX=9606 GN=EHBP1 PE=1 SV=3" "0.000" "False" "14.072" "4" "4" "4" "4" "1231" "139.9" "5.35" "15.58" "4" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf00307, Pf10358, Pf12130" "23301" "ENSG00000115504" "EHBP1" "hsa:23301; O94977; Q53TG7; Q53TV6; Q580X2; Q6NX72; Q6PIT3; Q6QNV2; Q8NDI1; Q9NWI9" "Ciliary landscape" "" "1" "0" "0.870" "0.843" "1.033" "0.994" "1.020" "1.012" "0.990" "0.890" "1.289" "134.8" "117.2" "113.7" "139.2" "134.0" "137.5" "136.4" "133.5" "120.0" "173.7" "" "" "" "" "" "" "" "" "" "" "121.2" "94.8" "102.8" "135.9" "110.6" "137.5" "102.2" "117.9" "107.3" "62.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2619952528215347024" "False" "High" "IsMasterProtein" "P09326" "CD48 antigen OS=Homo sapiens OX=9606 GN=CD48 PE=1 SV=2" "0.000" "False" "14.068" "15" "4" "5" "4" "243" "27.7" "8.07" "15.53" "4" "stress response" "plasma membrane;other membranes" "" "Pf07686, Pf13895" "962" "ENSG00000117091" "CD48" "hsa:962; P09326; Q5U055; Q8MGR0" "Gastric cancer network 2" "Cell surface interactions at the vascular wall" "2" "0" "1.016" "0.892" "0.938" "1.002" "0.903" "0.960" "0.864" "0.831" "0.659" "436.2" "442.9" "389.0" "409.2" "436.9" "394.0" "418.6" "376.9" "362.6" "287.3" "" "" "" "" "" "" "" "" "" "" "392.2" "358.4" "351.8" "399.5" "360.5" "394.0" "313.4" "332.9" "324.4" "102.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7563735417890983721" "False" "High" "IsMasterProtein" "P41208" "Centrin-2 OS=Homo sapiens OX=9606 GN=CETN2 PE=1 SV=1" "0.000" "False" "14.062" "19" "3" "4" "3" "172" "19.7" "5.00" "14.99" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1069" "ENSG00000147400; ENSG00000292191" "CETN2" "B2R4T4; hsa:1069; P41208; Q53XW1" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Recruitment of NuMA to mitotic centrosomes; SUMOylation of DNA damage response and repair proteins; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "13" "0" "0.980" "1.082" "0.959" "1.061" "1.148" "1.030" "1.140" "1.089" "1.044" "501.5" "491.6" "542.8" "480.9" "532.0" "576.0" "516.6" "572.0" "546.2" "523.5" "" "" "" "" "" "" "" "" "" "" "450.9" "397.8" "491.0" "469.4" "439.0" "576.0" "386.8" "505.2" "488.7" "186.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9085991407022296267" "False" "High" "IsMasterProtein" "P01920" "HLA class II histocompatibility antigen, DQ beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DQB1 PE=1 SV=2" "0.000" "False" "14.020" "11" "4" "5" "4" "261" "30.0" "7.25" "21.78" "4" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00969, Pf07654" "3119" "ENSG00000225824; ENSG00000231286; ENSG00000233209" "HLA-DQB1" "A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; C8ZLJ9; C9DRQ3; hsa:3119; O19708; O19713; O19724; O62861; O78046; O78221; O78223; O98034; O98201; P01917; P01918; P01919; P01920; P03992; P05537; P79482; P79526; P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2" "Allograft rejection" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "8" "0" "1.039" "0.886" "1.326" "0.985" "0.944" "1.044" "1.192" "1.048" "1.008" "355.2" "369.1" "314.7" "471.1" "349.9" "335.5" "371.0" "423.3" "372.3" "358.2" "" "" "" "" "" "" "" "" "" "" "319.4" "298.7" "284.6" "459.9" "288.7" "335.5" "277.8" "373.9" "333.2" "127.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1558588285545917257" "False" "High" "IsMasterProtein" "O75531" "Barrier-to-autointegration factor OS=Homo sapiens OX=9606 GN=BANF1 PE=1 SV=1" "0.000" "False" "14.006" "51" "6" "11" "6" "89" "10.1" "6.09" "28.01" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02961" "8815" "ENSG00000175334" "BANF1" "hsa:8815; O60558; O75531; Q6FGG7" "Envelope proteins and their potential roles in EDMD physiopathology; Familial partial lipodystrophy; Progeria-associated lipodystrophy" "Vpr-mediated nuclear import of PICs; 2-LTR circle formation; Integration of viral DNA into host genomic DNA; Autointegration results in viral DNA circles; APOBEC3G mediated resistance to HIV-1 infection; Nuclear Envelope Breakdown; Initiation of Nuclear Envelope (NE) Reformation" "11" "0" "0.963" "0.943" "1.062" "0.983" "1.064" "1.056" "1.081" "0.929" "0.217" "973.9" "937.6" "918.6" "1034.0" "956.9" "1036.0" "1028.8" "1052.9" "905.0" "211.3" "" "" "" "" "" "" "" "" "" "" "875.6" "758.7" "830.9" "1009.3" "789.6" "1036.0" "770.3" "930.0" "809.8" "75.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "316205606070741097" "False" "High" "IsMasterProtein" "Q5JTD0" "Tight junction-associated protein 1 OS=Homo sapiens OX=9606 GN=TJAP1 PE=1 SV=1" "0.000" "False" "14.006" "8" "4" "4" "4" "557" "61.8" "5.97" "16.27" "4" "cell organization and biogenesis" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf15453" "93643" "ENSG00000137221" "TJAP1" "hsa:93643; Q05BH9; Q5JTD0; Q5JTD1; Q5JWW1; Q68DB2; Q6P2P3; Q9H7V7" "" "" "0" "0" "1.059" "1.185" "0.993" "1.251" "1.243" "1.192" "1.162" "1.218" "1.124" "305.7" "323.9" "362.2" "303.6" "382.4" "379.9" "364.3" "355.3" "372.5" "343.5" "" "" "" "" "" "" "" "" "" "" "274.9" "262.1" "327.6" "296.4" "315.5" "379.9" "272.8" "313.8" "333.3" "122.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8995657341512938219" "False" "High" "IsMasterProtein" "P47914" "Large ribosomal subunit protein eL29 OS=Homo sapiens OX=9606 GN=RPL29 PE=1 SV=2" "0.000" "False" "13.990" "19" "3" "5" "3" "159" "17.7" "11.66" "14.51" "3" "protein metabolism;other metabolic processes;developmental processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01779" "6159" "ENSG00000162244" "RPL29" "A8K0H3; B2R4M8; hsa:6159; P47914; Q6IPY3" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.013" "0.933" "1.013" "1.054" "1.004" "0.984" "1.073" "0.924" "0.725" "681.0" "689.6" "635.1" "689.5" "717.6" "684.0" "670.3" "730.7" "628.9" "493.5" "" "" "" "" "" "" "" "" "" "" "612.2" "558.0" "574.5" "673.1" "592.2" "684.0" "501.9" "645.4" "562.7" "176.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4972524321603701932" "False" "High" "IsMasterProtein" "Q8IW35" "Centrosomal protein of 97 kDa OS=Homo sapiens OX=9606 GN=CEP97 PE=1 SV=1" "0.000" "False" "13.963" "4" "3" "4" "3" "865" "96.9" "5.02" "13.55" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf14580" "79598" "ENSG00000182504" "CEP97" "B5MDY8; hsa:79598; Q8IW35; Q8NA71; Q9H5T9" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome" "Anchoring of the basal body to the plasma membrane; RHOV GTPase cycle" "5" "0" "1.068" "1.046" "1.050" "1.102" "1.019" "1.158" "1.006" "1.018" "1.203" "214.5" "229.1" "224.4" "225.2" "236.4" "218.5" "248.5" "215.8" "218.3" "258.1" "" "" "" "" "" "" "" "" "" "" "192.9" "185.4" "203.0" "219.8" "195.0" "218.5" "186.0" "190.6" "195.3" "92.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3992202401745413050" "False" "High" "IsMasterProtein" "O75044" "SLIT-ROBO Rho GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=SRGAP2 PE=1 SV=3" "0.000" "False" "13.933" "4" "5" "5" "5" "1071" "120.8" "6.70" "10.24" "5" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00611, Pf00620" "23380" "ENSG00000266028" "SRGAP2" "A2RUF3; hsa:23380; O75044" "" "CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RAC3 GTPase cycle; RHOF GTPase cycle; RHO GTPases Activate Formins; RHOU GTPase cycle; Inactivation of CDC42 and RAC1" "8" "0" "0.929" "0.907" "0.951" "0.903" "0.957" "1.036" "0.887" "0.974" "1.589" "256.5" "238.3" "232.7" "244.0" "231.7" "245.6" "265.6" "227.5" "250.0" "407.5" "" "" "" "" "" "" "" "" "" "" "230.6" "192.8" "210.5" "238.2" "191.2" "245.6" "198.9" "200.9" "223.7" "145.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8893850793131937072" "False" "High" "IsMasterProtein" "O95749" "Geranylgeranyl pyrophosphate synthase OS=Homo sapiens OX=9606 GN=GGPS1 PE=1 SV=1" "0.000" "False" "13.930" "15" "4" "4" "4" "300" "34.8" "6.14" "14.69" "4" "other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00348" "9453" "ENSG00000152904" "GGPS1" "A8MVQ8; hsa:9453; O95749; Q5T2C8; Q6NW19" "Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis pathway in hepatocytes" "Activation of gene expression by SREBF (SREBP); Cholesterol biosynthesis" "4" "0" "1.046" "0.935" "0.885" "1.061" "0.979" "1.063" "0.951" "0.966" "0.901" "342.8" "358.6" "320.5" "303.2" "363.8" "335.5" "364.3" "326.0" "331.0" "308.8" "" "" "" "" "" "" "" "" "" "" "308.2" "290.2" "289.9" "296.0" "300.2" "335.5" "272.8" "288.0" "296.2" "110.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7689745804882425318" "False" "High" "IsMasterProtein" "Q6XQN6" "Nicotinate phosphoribosyltransferase OS=Homo sapiens OX=9606 GN=NAPRT PE=1 SV=2" "0.000" "False" "13.928" "9" "4" "4" "4" "538" "57.5" "5.68" "16.28" "4" "other metabolic processes;stress response" "non-structural extracellular;cytosol;other cytoplasmic organelle" "other molecular function" "Pf17767, Pf17956" "93100" "ENSG00000147813; ENSG00000278488" "NAPRT" "A7BFI3; hsa:93100; Q6PJL1; Q6XQN4; Q6XQN5; Q6XQN6; Q8N5E8; Q9BRG0" "NAD+ biosynthetic pathways" "Neutrophil degranulation; Nicotinamide salvaging" "3" "0" "0.928" "0.963" "0.909" "0.980" "0.999" "1.063" "1.005" "0.932" "1.159" "224.9" "208.7" "216.6" "204.5" "220.4" "224.7" "239.0" "226.0" "209.6" "260.7" "" "" "" "" "" "" "" "" "" "" "202.2" "168.9" "195.9" "199.6" "181.9" "224.7" "179.0" "199.6" "187.6" "93.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "577500699946211837" "False" "High" "IsMasterProtein" "Q8NFQ8" "Torsin-1A-interacting protein 2 OS=Homo sapiens OX=9606 GN=TOR1AIP2 PE=1 SV=1" "0.000" "False" "13.915" "11" "4" "4" "4" "470" "51.2" "4.96" "17.97" "4" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf05609, Pf20443" "163590" "ENSG00000169905" "TOR1AIP2" "hsa:163590; Q8NFQ8" "" "" "0" "0" "1.027" "0.998" "1.041" "1.006" "0.914" "0.973" "1.120" "0.961" "0.672" "220.5" "226.4" "220.1" "229.4" "221.8" "201.6" "214.5" "246.9" "212.0" "148.3" "" "" "" "" "" "" "" "" "" "" "198.2" "183.2" "199.1" "223.9" "183.0" "201.6" "160.6" "218.1" "189.7" "52.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3570886289104636423" "False" "High" "IsMasterProtein" "Q9NYP9" "Protein Mis18-alpha OS=Homo sapiens OX=9606 GN=MIS18A PE=1 SV=1" "0.000" "False" "13.872" "24" "5" "5" "5" "233" "25.8" "5.20" "19.22" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03226" "54069" "ENSG00000159055" "MIS18A" "B2R562; hsa:54069; Q542Z0; Q9NYP9" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "0.925" "1.060" "0.953" "1.018" "1.065" "0.978" "0.971" "1.043" "0.746" "771.6" "713.5" "818.0" "735.2" "785.7" "821.6" "755.0" "749.1" "805.0" "575.6" "" "" "" "" "" "" "" "" "" "" "693.7" "577.3" "739.9" "717.6" "648.4" "821.6" "565.3" "661.7" "720.3" "205.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4153058016593714536" "False" "High" "IsMasterProtein" "Q9UKT5" "F-box only protein 4 OS=Homo sapiens OX=9606 GN=FBXO4 PE=1 SV=2" "0.000" "False" "13.862" "12" "4" "4" "4" "387" "44.1" "6.16" "14.36" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646" "26272" "ENSG00000151876" "FBXO4" "hsa:26272; Q68CU8; Q86VT8; Q9UK98; Q9UKT5" "" "Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "0.948" "0.959" "0.893" "0.972" "0.956" "1.026" "0.920" "0.992" "1.136" "325.2" "308.4" "311.9" "290.5" "316.0" "311.0" "333.7" "299.3" "322.6" "369.3" "" "" "" "" "" "" "" "" "" "" "292.4" "249.5" "282.1" "283.6" "260.8" "311.0" "249.9" "264.4" "288.7" "131.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7841713393868884800" "False" "High" "IsMasterProtein" "Q9BSL1" "Ubiquitin-associated domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBAC1 PE=1 SV=1" "0.000" "False" "13.861" "11" "5" "5" "5" "405" "45.3" "4.92" "16.79" "5" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00627" "10422" "ENSG00000130560" "UBAC1" "hsa:10422; O75500; Q9BSL1; Q9UMW7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.914" "0.973" "0.834" "0.979" "0.966" "0.980" "0.891" "1.020" "1.006" "420.0" "383.7" "408.7" "350.4" "411.4" "405.7" "411.5" "374.2" "428.2" "422.4" "" "" "" "" "" "" "" "" "" "" "377.7" "310.5" "369.6" "342.1" "339.5" "405.7" "308.1" "330.5" "383.2" "150.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8563797319587415269" "False" "High" "IsMasterProtein" "P25208" "Nuclear transcription factor Y subunit beta OS=Homo sapiens OX=9606 GN=NFYB PE=1 SV=2" "0.000" "False" "13.833" "20" "3" "4" "3" "207" "22.8" "4.59" "13.90" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00808" "4801" "ENSG00000120837" "NFYB" "A8K7B9; hsa:4801; P25208; Q96IY8" "" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "5" "0" "1.125" "0.964" "0.881" "1.049" "0.995" "0.946" "0.958" "0.905" "0.902" "73.1" "82.3" "70.5" "64.4" "76.7" "72.8" "69.2" "70.1" "66.2" "66.0" "" "" "" "" "" "" "" "" "" "" "65.7" "66.6" "63.7" "62.9" "63.3" "72.8" "51.8" "61.9" "59.2" "23.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5438538710980627953" "False" "High" "IsMasterProtein" "Q9H2C0" "Gigaxonin OS=Homo sapiens OX=9606 GN=GAN PE=1 SV=1" "0.000" "False" "13.817" "11" "5" "6" "5" "597" "67.6" "5.85" "17.21" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;cytoskeleton;other cell component" "" "Pf00651, Pf01344, Pf07707" "8139" "ENSG00000261609" "GAN" "hsa:8139; Q9H2C0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.055" "1.068" "1.063" "1.114" "1.097" "1.102" "1.028" "1.100" "1.047" "245.6" "259.2" "262.2" "261.0" "273.5" "269.5" "270.7" "252.5" "270.1" "257.1" "" "" "" "" "" "" "" "" "" "" "220.8" "209.7" "237.2" "254.7" "225.7" "269.5" "202.7" "223.0" "241.7" "91.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6226740505465900925" "False" "High" "IsMasterProtein" "Q08170" "Serine/arginine-rich splicing factor 4 OS=Homo sapiens OX=9606 GN=SRSF4 PE=1 SV=2" "0.000" "False" "13.811" "8" "4" "7" "1" "494" "56.6" "11.52" "23.84" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6429" "ENSG00000116350" "SRSF4" "hsa:6429; Q08170; Q5VXP1; Q9BUA4; Q9UEB5" "mRNA processing" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "6" "1" "0.942" "0.998" "1.034" "0.944" "1.071" "1.094" "0.964" "0.965" "0.954" "298.3" "280.8" "297.8" "308.3" "281.5" "319.3" "326.3" "287.7" "287.7" "284.7" "" "" "" "" "" "" "" "" "" "" "268.2" "227.3" "269.3" "300.9" "232.3" "319.3" "244.3" "254.1" "257.5" "101.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1141936988023863748" "False" "High" "IsMasterProtein" "Q9NP61" "ADP-ribosylation factor GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=ARFGAP3 PE=1 SV=1" "0.000" "False" "13.810" "9" "5" "5" "5" "516" "56.9" "7.36" "18.63" "5" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf01412" "26286" "ENSG00000242247" "ARFGAP3" "E9PB03; hsa:26286; Q9BSC6; Q9H9J0; Q9NP61; Q9NT10; Q9NUP5; Q9Y4V3; Q9Y4V4" "Ciliary landscape" "COPI-mediated anterograde transport; CDC42 GTPase cycle; RHOG GTPase cycle; COPI-dependent Golgi-to-ER retrograde traffic" "5" "0" "1.075" "1.194" "0.988" "1.096" "1.140" "1.107" "1.097" "1.180" "0.998" "366.8" "394.3" "437.9" "362.3" "401.9" "418.0" "406.1" "402.5" "432.7" "366.0" "" "" "" "" "" "" "" "" "" "" "329.8" "319.0" "396.1" "353.6" "331.7" "418.0" "304.0" "355.5" "387.2" "130.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-263774820605261131" "False" "High" "IsMasterProtein" "Q9BTK6" "PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=PAGR1 PE=1 SV=1" "0.000" "False" "13.810" "15" "3" "4" "3" "254" "27.7" "4.46" "18.43" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "Pf15364" "79447" "ENSG00000280789" "PAGR1" "A2ICR6; hsa:79447; Q9BTK6" "16p11.2 proximal deletion syndrome; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis" "4" "0" "0.923" "0.954" "0.951" "1.072" "0.976" "1.052" "1.033" "1.083" "1.051" "175.8" "162.2" "167.6" "167.2" "188.4" "171.5" "185.0" "181.6" "190.3" "184.8" "" "" "" "" "" "" "" "" "" "" "158.0" "131.3" "151.6" "163.2" "155.4" "171.5" "138.5" "160.4" "170.3" "66.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6134268530089920080" "False" "High" "IsMasterProtein" "P09668" "Pro-cathepsin H OS=Homo sapiens OX=9606 GN=CTSH PE=1 SV=4" "0.000" "False" "13.809" "10" "3" "4" "3" "335" "37.4" "8.07" "16.09" "3" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00112, Pf08246" "1512" "ENSG00000103811" "CTSH" "B2RBK0; hsa:1512; P09668; Q96NY6; Q9BUM7" "" "MHC class II antigen presentation; Neutrophil degranulation; Surfactant metabolism" "3" "0" "0.959" "1.001" "0.979" "1.017" "0.897" "0.937" "1.000" "1.001" "0.851" "654.3" "627.2" "655.2" "640.7" "665.2" "586.7" "613.4" "654.4" "655.0" "556.7" "" "" "" "" "" "" "" "" "" "" "588.3" "507.5" "592.6" "625.4" "548.9" "586.7" "459.3" "578.1" "586.1" "198.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6020211284576112703" "False" "High" "IsMasterProtein" "Q86UY8" "5'-nucleotidase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NT5DC3 PE=1 SV=1" "0.000" "False" "13.807" "9" "5" "6" "5" "548" "63.4" "8.31" "19.03" "5" "" "cytosol;other cell component" "other molecular function" "Pf05761" "51559" "ENSG00000111696" "NT5DC3" "hsa:51559; Q86UY8; Q9NUM7; Q9P2T2; Q9P2T3" "" "" "0" "0" "1.032" "1.075" "0.957" "1.071" "1.077" "1.042" "1.001" "1.101" "1.101" "577.9" "596.5" "621.3" "552.8" "618.7" "622.5" "602.4" "578.4" "636.1" "636.0" "" "" "" "" "" "" "" "" "" "" "519.6" "482.7" "562.0" "539.6" "510.6" "622.5" "451.0" "510.9" "569.2" "227.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5539226776075582677" "False" "High" "IsMasterProtein" "Q5TC82" "Roquin-1 OS=Homo sapiens OX=9606 GN=RC3H1 PE=1 SV=1" "0.000" "False" "13.806" "4" "4" "4" "4" "1133" "125.7" "7.27" "13.38" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf14634, Pf18386, Pf21206" "149041" "ENSG00000135870" "RC3H1" "B3KVK1; hsa:149041; Q5TC82; Q5W180; Q5W181; Q8IVE6; Q8N9V1" "" "" "0" "0" "0.962" "0.812" "0.641" "1.041" "0.670" "1.019" "0.916" "0.853" "0.854" "31.2" "30.0" "25.3" "20.0" "32.5" "20.9" "31.8" "28.6" "26.6" "26.6" "" "" "" "" "" "" "" "" "" "" "28.0" "24.3" "22.9" "19.5" "26.8" "20.9" "23.8" "25.2" "23.8" "9.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-675276312923681114" "False" "High" "IsMasterProtein" "Q96GY0" "Zinc finger C2HC domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ZC2HC1A PE=1 SV=2" "0.000" "False" "13.800" "13" "5" "5" "5" "325" "35.1" "9.82" "16.11" "5" "" "" "other molecular function" "Pf13913" "51101" "ENSG00000104427" "ZC2HC1A" "hsa:51101; Q96GY0; Q9Y372" "" "" "0" "0" "0.918" "0.917" "0.980" "1.013" "1.013" "1.087" "1.094" "1.124" "0.838" "266.6" "244.8" "244.5" "261.2" "270.1" "270.1" "289.7" "291.6" "299.5" "223.3" "" "" "" "" "" "" "" "" "" "" "239.7" "198.1" "221.1" "255.0" "222.9" "270.1" "216.9" "257.6" "268.0" "79.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6553224162090552303" "False" "High" "IsMasterProtein" "Q9Y3A3" "MOB-like protein phocein OS=Homo sapiens OX=9606 GN=MOB4 PE=1 SV=1" "0.000" "False" "13.794" "20" "4" "6" "4" "225" "26.0" "5.78" "18.99" "4" "" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03637" "25843" "ENSG00000115540" "MOB4" "B4DML0; hsa:25843; Q53SE0; Q7Z4Y6; Q9H2P3; Q9H5J1; Q9Y3A3; Q9Y4T8" "" "" "0" "0" "1.092" "1.050" "1.026" "1.112" "1.015" "1.154" "1.060" "1.002" "0.821" "524.4" "572.7" "550.5" "538.1" "582.9" "532.1" "605.2" "556.0" "525.5" "430.6" "" "" "" "" "" "" "" "" "" "" "471.5" "463.4" "498.0" "525.3" "481.0" "532.1" "453.1" "491.1" "470.3" "153.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7880695163940437874" "False" "High" "IsMasterProtein" "Q9Y580" "RNA-binding protein 7 OS=Homo sapiens OX=9606 GN=RBM7 PE=1 SV=1" "0.000" "False" "13.792" "19" "4" "4" "4" "266" "30.5" "9.57" "15.82" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "10179" "ENSG00000076053" "RBM7" "B2R6K8; hsa:10179; Q9NUT4; Q9Y580" "" "mRNA Splicing - Major Pathway" "1" "0" "0.994" "1.016" "0.893" "0.962" "1.068" "0.934" "1.006" "1.101" "1.386" "260.4" "258.7" "264.4" "232.4" "250.5" "278.0" "243.1" "261.8" "286.5" "360.7" "" "" "" "" "" "" "" "" "" "" "234.1" "209.3" "239.2" "226.8" "206.7" "278.0" "182.0" "231.2" "256.4" "128.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "247879969936268411" "False" "High" "IsMasterProtein" "O94992" "Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1" "0.000" "False" "13.786" "13" "4" "6" "3" "359" "40.6" "4.89" "22.38" "4" "stress response;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "10614" "ENSG00000186834" "HEXIM1" "B2R8Y5; hsa:10614; O94992" "Initiation of transcription and translation elongation at the HIV-1 LTR" "" "1" "1" "0.962" "0.969" "0.937" "0.925" "0.957" "0.920" "1.011" "0.927" "0.878" "834.4" "802.5" "808.5" "781.7" "771.7" "798.9" "767.4" "843.4" "773.2" "732.7" "" "" "" "" "" "" "" "" "" "" "750.2" "649.4" "731.3" "763.1" "636.8" "798.9" "574.6" "744.9" "691.9" "261.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8657870357206849576" "False" "High" "IsMasterProtein" "Q9Y2Y0" "ADP-ribosylation factor-like protein 2-binding protein OS=Homo sapiens OX=9606 GN=ARL2BP PE=1 SV=1" "0.000" "False" "13.785" "17" "2" "4" "2" "163" "18.8" "4.35" "17.33" "2" "signal transduction;other biological processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11527" "23568" "ENSG00000102931" "ARL2BP" "B3KQJ5; hsa:23568; Q504R0; Q9Y2Y0" "Ciliopathies" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane" "2" "0" "0.967" "1.036" "0.863" "0.889" "0.961" "0.896" "0.863" "0.960" "1.214" "521.0" "503.9" "539.5" "449.7" "463.2" "500.7" "466.6" "449.8" "499.9" "632.5" "" "" "" "" "" "" "" "" "" "" "468.4" "407.7" "488.0" "439.0" "382.2" "500.7" "349.4" "397.3" "447.3" "225.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5564485370032939878" "False" "High" "IsMasterProtein" "Q9UBV8" "Peflin OS=Homo sapiens OX=9606 GN=PEF1 PE=1 SV=1" "0.000" "False" "13.769" "14" "4" "8" "4" "284" "30.4" "6.54" "23.74" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf13405, Pf13499" "553115" "ENSG00000162517" "PEF1" "hsa:553115; Q9UBV8" "" "" "0" "0" "1.067" "1.036" "1.003" "1.150" "0.985" "1.094" "1.093" "1.029" "1.039" "806.0" "860.2" "834.7" "808.3" "926.6" "794.3" "881.8" "880.9" "829.2" "837.6" "" "" "" "" "" "" "" "" "" "" "724.7" "696.1" "755.0" "789.0" "764.6" "794.3" "660.3" "778.1" "742.0" "299.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6957065747657519198" "False" "High" "IsMasterProtein" "P33552" "Cyclin-dependent kinases regulatory subunit 2 OS=Homo sapiens OX=9606 GN=CKS2 PE=1 SV=1" "0.000" "False" "13.756" "33" "3" "6" "2" "79" "9.9" "8.46" "18.11" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1164" "ENSG00000123975" "CKS2" "hsa:1164; P33552; Q6FGI9; Q6LET5" "Small cell lung cancer" "" "1" "0" "1.106" "0.965" "0.957" "1.104" "1.021" "0.956" "0.999" "0.987" "1.527" "173.7" "192.0" "167.7" "166.2" "191.7" "177.3" "166.0" "173.4" "171.5" "265.1" "" "" "" "" "" "" "" "" "" "" "156.2" "155.4" "151.7" "162.2" "158.2" "177.3" "124.3" "153.2" "153.4" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3656789324422396877" "False" "High" "IsMasterProtein" "P11912" "B-cell antigen receptor complex-associated protein alpha chain OS=Homo sapiens OX=9606 GN=CD79A PE=1 SV=2" "0.000" "False" "13.755" "14" "2" "4" "2" "226" "25.0" "5.00" "20.89" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00047, Pf02189" "973" "ENSG00000105369" "CD79A" "A0N775; hsa:973; P11912; Q53FB8" "B cell receptor signaling pathway; Extrafollicular and follicular B cell activation by SARS-CoV-2" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "5" "0" "0.930" "1.027" "1.006" "0.982" "1.020" "0.920" "1.093" "1.181" "0.820" "359.9" "334.7" "369.5" "362.0" "353.5" "367.0" "331.1" "393.5" "425.2" "295.2" "" "" "" "" "" "" "" "" "" "" "323.6" "270.9" "334.2" "353.4" "291.7" "367.0" "247.9" "347.5" "380.4" "105.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4967759419043337591" "False" "High" "IsMasterProtein" "Q9UJ83" "2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens OX=9606 GN=HACL1 PE=1 SV=2" "0.000" "False" "13.745" "9" "4" "4" "4" "578" "63.7" "7.36" "15.49" "4" "cell organization and biogenesis;other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "26061" "ENSG00000131373" "HACL1" "B4DWI1; B4DXI5; E9PEN4; hsa:26061; Q9BV42; Q9P0A2; Q9UJ83" "" "Peroxisomal protein import; Alpha-oxidation of phytanate" "2" "0" "1.121" "1.107" "0.926" "1.033" "1.151" "1.073" "1.026" "1.046" "1.025" "402.4" "451.1" "445.6" "372.8" "415.8" "463.1" "431.9" "413.0" "421.0" "412.4" "" "" "" "" "" "" "" "" "" "" "361.8" "365.0" "403.1" "363.9" "343.1" "463.1" "323.4" "364.8" "376.7" "147.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2869722740218249638" "False" "High" "IsMasterProtein" "Q9Y6M4" "Casein kinase I isoform gamma-3 OS=Homo sapiens OX=9606 GN=CSNK1G3 PE=1 SV=2" "0.000" "False" "13.742" "11" "5" "5" "1" "447" "51.4" "9.22" "16.40" "5" "cell-cell signaling;protein metabolism;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf12605" "1456" "ENSG00000151292" "CSNK1G3" "A8K040; B4DSH2; B7Z9Q4; E7EVD0; hsa:1456; Q86WZ7; Q9Y6M3; Q9Y6M4" "Hedgehog signaling pathway" "" "1" "0" "1.020" "0.976" "0.859" "1.105" "0.963" "1.029" "0.981" "0.895" "0.809" "118.0" "120.3" "115.1" "101.3" "130.3" "113.7" "121.4" "115.7" "105.6" "95.4" "" "" "" "" "" "" "" "" "" "" "106.1" "97.4" "104.1" "98.9" "107.5" "113.7" "90.9" "102.2" "94.5" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2771631356277906494" "False" "High" "IsMasterProtein" "Q01650" "Large neutral amino acids transporter small subunit 1 OS=Homo sapiens OX=9606 GN=SLC7A5 PE=1 SV=2" "0.000" "False" "13.730" "6" "2" "3" "2" "507" "55.0" "7.72" "15.21" "2" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf13520" "8140" "ENSG00000103257" "SLC7A5" "hsa:8140; Q01650; Q8IV97; Q9UBN8; Q9UP15; Q9UQC0" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; mRNA, protein, and metabolite inducation pathway by cyclosporin A; Pleural mesothelioma" "Tryptophan catabolism; Basigin interactions; Amino acid transport across the plasma membrane" "7" "0" "0.933" "0.943" "0.985" "0.974" "0.910" "0.891" "0.854" "0.918" "0.716" "171.3" "159.9" "161.5" "168.7" "166.9" "155.9" "152.7" "146.3" "157.2" "122.7" "" "" "" "" "" "" "" "" "" "" "154.0" "129.4" "146.1" "164.7" "137.7" "155.9" "114.3" "129.2" "140.7" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2247702318764912013" "False" "High" "IsMasterProtein" "Q8NI22" "Multiple coagulation factor deficiency protein 2 OS=Homo sapiens OX=9606 GN=MCFD2 PE=1 SV=1" "0.000" "False" "13.725" "25" "2" "5" "2" "146" "16.4" "4.63" "23.63" "2" "transport" "other membranes;ER/Golgi" "other molecular function" "Pf13499" "90411" "ENSG00000180398" "MCFD2" "A8K7W2; D6W5A9; E9PD95; hsa:90411; Q53SS3; Q68D61; Q8N3M5; Q8NI22" "" "COPII-mediated vesicle transport; Cargo concentration in the ER; Transport to the Golgi and subsequent modification" "3" "0" "0.861" "0.969" "0.881" "0.904" "0.922" "0.862" "0.940" "0.954" "0.617" "922.2" "793.7" "893.9" "812.6" "833.5" "850.1" "794.9" "866.8" "880.2" "569.1" "" "" "" "" "" "" "" "" "" "" "829.1" "642.2" "808.6" "793.2" "687.9" "850.1" "595.2" "765.6" "787.6" "203.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4410933930265088231" "False" "High" "IsMasterProtein" "P14927" "Cytochrome b-c1 complex subunit 7 OS=Homo sapiens OX=9606 GN=UQCRB PE=1 SV=2" "0.000" "False" "13.719" "42" "5" "5" "5" "111" "13.5" "8.78" "17.95" "5" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02271" "7381" "ENSG00000156467" "UQCRB" "E5RJU0; hsa:7381; P14927; Q6FGD1" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "0.960" "1.060" "0.912" "1.011" "1.101" "1.033" "0.967" "0.953" "1.254" "461.0" "442.7" "488.7" "420.3" "465.9" "507.7" "476.1" "445.6" "439.3" "578.1" "" "" "" "" "" "" "" "" "" "" "414.5" "358.3" "442.0" "410.3" "384.5" "507.7" "356.5" "393.6" "393.1" "206.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1117159967779804568" "False" "High" "IsMasterProtein" "Q7L4I2" "Arginine/serine-rich coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=RSRC2 PE=1 SV=1" "0.000" "False" "13.706" "10" "4" "4" "4" "434" "50.5" "11.33" "14.34" "4" "" "" "" "Pf15477" "65117" "ENSG00000111011" "RSRC2" "hsa:65117; Q6N040; Q6NW16; Q7L4I2; Q9H864" "" "" "0" "0" "0.907" "0.920" "0.902" "1.027" "0.991" "1.019" "0.953" "0.920" "0.708" "359.6" "326.1" "330.9" "324.5" "369.4" "356.5" "366.4" "342.7" "330.9" "254.6" "" "" "" "" "" "" "" "" "" "" "323.3" "263.9" "299.3" "316.8" "304.9" "356.5" "274.3" "302.7" "296.1" "90.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8566707279340017586" "False" "High" "IsMasterProtein" "Q9Y6M7" "Sodium bicarbonate cotransporter 3 OS=Homo sapiens OX=9606 GN=SLC4A7 PE=1 SV=2" "0.000" "False" "13.697" "4" "5" "7" "5" "1214" "136.0" "6.71" "23.94" "5" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00955, Pf07565" "9497" "ENSG00000033867" "SLC4A7" "A6NIA8; B2CI53; B5M449; B5M451; B5M452; B5M453; B6DY52; B6DY53; C9JST9; D3K174; D3K175; hsa:9497; O60350; Q6AHZ9; Q9HC88; Q9UIB9; Q9Y6M7" "IL-18 signaling pathway" "RHOQ GTPase cycle; RHOJ GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOH GTPase cycle; Bicarbonate transporters" "7" "0" "1.092" "1.037" "1.132" "1.219" "1.041" "1.086" "1.139" "1.107" "0.806" "406.5" "444.0" "421.7" "460.0" "495.5" "423.3" "441.4" "462.9" "449.9" "327.6" "" "" "" "" "" "" "" "" "" "" "365.5" "359.2" "381.4" "449.0" "408.9" "423.3" "330.5" "408.8" "402.6" "116.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7436482478148807515" "False" "High" "IsMasterProtein" "Q86TB9" "Protein PAT1 homolog 1 OS=Homo sapiens OX=9606 GN=PATL1 PE=1 SV=2" "0.000" "False" "13.669" "5" "4" "5" "4" "770" "86.8" "6.67" "14.55" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf09770" "219988" "ENSG00000166889" "PATL1" "B3KXT9; hsa:219988; Q2TA86; Q6P166; Q86TB9; Q8N9M6; Q8NI63" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "0.856" "0.810" "0.864" "0.966" "0.970" "0.914" "0.795" "0.731" "1.506" "184.2" "157.6" "149.2" "159.1" "177.9" "178.6" "168.3" "146.4" "134.7" "277.3" "" "" "" "" "" "" "" "" "" "" "165.6" "127.5" "135.0" "155.3" "146.8" "178.6" "126.0" "129.3" "120.5" "99.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1247972566185408077" "False" "High" "IsMasterProtein" "Q9UNT1" "Rab-like protein 2B OS=Homo sapiens OX=9606 GN=RABL2B PE=1 SV=1" "0.000" "False" "13.666" "14" "3" "4" "3" "228" "26.1" "4.89" "14.03" "3" "cell organization and biogenesis;transport" "cytoskeleton;other cell component" "other molecular function" "Pf00071" "11158" "ENSG00000079974" "RABL2B" "hsa:11158; Q5TZT8; Q96C33; Q9UNT1" "3q29 copy number variation syndrome" "" "1" "0" "1.201" "1.014" "0.919" "1.121" "1.030" "1.191" "1.044" "1.044" "1.116" "175.6" "211.0" "178.1" "161.4" "196.9" "180.8" "209.1" "183.3" "183.4" "196.0" "" "" "" "" "" "" "" "" "" "" "157.9" "170.7" "161.1" "157.6" "162.5" "180.8" "156.6" "161.9" "164.1" "70.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5224017387005900556" "False" "High" "IsMasterProtein" "Q9Y4A5" "Transformation/transcription domain-associated protein OS=Homo sapiens OX=9606 GN=TRRAP PE=1 SV=3" "0.000" "False" "13.651" "2" "7" "7" "6" "3859" "437.3" "8.19" "14.72" "7" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00454, Pf02259, Pf20175, Pf20206" "8295" "ENSG00000196367" "TRRAP" "A4D265; hsa:8295; O75218; Q9Y4A5; Q9Y631; Q9Y6H4" "Rett syndrome" "Ub-specific processing proteases; Formation of the beta-catenin:TCF transactivating complex; HATs acetylate histones" "4" "1" "0.999" "0.986" "0.959" "1.079" "0.976" "1.026" "1.075" "1.007" "0.914" "426.5" "426.0" "420.7" "408.9" "460.1" "416.2" "437.4" "458.4" "429.6" "390.0" "" "" "" "" "" "" "" "" "" "" "383.5" "344.7" "380.5" "399.2" "379.7" "416.2" "327.5" "404.9" "384.4" "139.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159799509992601123" "False" "High" "IsMasterProtein" "Q96FK6" "WD repeat-containing protein 89 OS=Homo sapiens OX=9606 GN=WDR89 PE=1 SV=1" "0.000" "False" "13.611" "11" "3" "3" "3" "387" "43.2" "6.13" "15.52" "3" "developmental processes" "" "" "Pf00400" "112840" "ENSG00000140006" "WDR89" "hsa:112840; Q96FK6" "" "" "0" "0" "1.059" "1.024" "1.155" "1.128" "1.028" "1.156" "1.063" "1.016" "0.738" "343.6" "364.0" "351.9" "396.7" "387.4" "353.2" "397.3" "365.4" "349.1" "253.5" "" "" "" "" "" "" "" "" "" "" "308.9" "294.5" "318.3" "387.2" "319.7" "353.2" "297.5" "322.7" "312.4" "90.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-378421800270237029" "False" "High" "IsMasterProtein" "Q5TZA2" "Rootletin OS=Homo sapiens OX=9606 GN=CROCC PE=1 SV=2" "0.000" "False" "13.603" "2" "4" "7" "3" "2017" "228.3" "5.49" "16.12" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf15035" "9696" "ENSG00000058453" "CROCC" "hsa:9696; Q2VHY3; Q5TZA2; Q66GT7; Q7Z2L4; Q7Z5D7" "" "" "0" "0" "0.982" "1.139" "1.106" "0.991" "1.083" "1.118" "1.252" "0.961" "0.887" "151.7" "149.0" "172.8" "167.8" "150.4" "164.3" "169.6" "189.9" "145.8" "134.5" "" "" "" "" "" "" "" "" "" "" "136.4" "120.6" "156.3" "163.8" "124.1" "164.3" "127.0" "167.8" "130.4" "48.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9119183533352449248" "False" "High" "IsMasterProtein" "Q9P0P8" "Mitochondrial transcription rescue factor 1 OS=Homo sapiens OX=9606 GN=MTRES1 PE=1 SV=1" "0.000" "False" "13.596" "12" "3" "4" "3" "240" "27.9" "9.29" "15.14" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "" "51250" "ENSG00000130349" "MTRES1" "B3KRG9; hsa:51250; Q9P0P8" "" "" "0" "0" "0.982" "0.949" "0.958" "0.962" "0.909" "0.927" "0.957" "0.929" "0.784" "556.0" "545.8" "527.6" "532.8" "534.8" "505.5" "515.6" "531.9" "516.5" "436.0" "" "" "" "" "" "" "" "" "" "" "499.9" "441.7" "477.2" "520.1" "441.3" "505.5" "386.1" "469.8" "462.2" "155.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-163153293796965969" "False" "High" "IsMasterProtein" "Q9NWB6" "Arginine and glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ARGLU1 PE=1 SV=1" "0.000" "False" "13.595" "14" "6" "6" "5" "273" "33.2" "10.35" "18.83" "6" "" "cytosol;mitochondrion;nucleus" "" "Pf15346" "55082" "ENSG00000134884" "ARGLU1" "B4E0Y3; hsa:55082; Q5T257; Q6IQ34; Q9NWB6" "" "" "0" "0" "0.954" "0.958" "0.886" "0.902" "0.964" "0.931" "0.934" "0.944" "0.976" "486.1" "463.7" "465.5" "430.7" "438.3" "468.8" "452.4" "453.9" "459.1" "474.5" "" "" "" "" "" "" "" "" "" "" "437.0" "375.2" "421.1" "420.4" "361.7" "468.8" "338.7" "400.9" "410.8" "169.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3862869163996360692" "False" "High" "IsMasterProtein" "Q7LBR1" "Charged multivesicular body protein 1b OS=Homo sapiens OX=9606 GN=CHMP1B PE=1 SV=1" "0.000" "False" "13.588" "16" "4" "7" "4" "199" "22.1" "8.10" "20.37" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "57132" "ENSG00000255112" "CHMP1B" "hsa:57132; Q7LBR1; Q96E89; Q9HD41" "" "" "0" "0" "0.975" "0.977" "0.948" "0.974" "0.929" "1.004" "1.034" "0.920" "0.762" "473.0" "461.0" "462.0" "448.5" "460.8" "439.6" "475.0" "489.2" "435.2" "360.3" "" "" "" "" "" "" "" "" "" "" "425.3" "373.0" "417.9" "437.8" "380.3" "439.6" "355.6" "432.1" "389.4" "128.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7798556211851200264" "False" "High" "IsMasterProtein" "Q96AX1" "Vacuolar protein sorting-associated protein 33A OS=Homo sapiens OX=9606 GN=VPS33A PE=1 SV=1" "0.000" "False" "13.582" "7" "5" "5" "5" "596" "67.6" "6.96" "15.98" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00995" "65082" "ENSG00000139719" "VPS33A" "Q547V4; Q96AX1; Q9H5Q0" "Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "4" "0" "0.955" "0.952" "0.914" "0.899" "0.917" "0.914" "0.921" "0.973" "1.329" "270.0" "257.8" "257.1" "246.9" "242.8" "247.6" "246.7" "248.7" "262.6" "358.9" "" "" "" "" "" "" "" "" "" "" "242.8" "208.6" "232.6" "241.0" "200.4" "247.6" "184.7" "219.6" "235.0" "128.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6693318422199107583" "False" "High" "IsMasterProtein" "Q9HBI0" "Gamma-parvin OS=Homo sapiens OX=9606 GN=PARVG PE=1 SV=1" "0.000" "False" "13.556" "14" "4" "4" "4" "331" "37.5" "5.49" "14.23" "4" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "64098" "ENSG00000138964" "PARVG" "B4DDW5; E7EVM6; hsa:64098; Q9BQX5; Q9HBI0; Q9NSG1" "Focal adhesion" "" "1" "0" "0.978" "0.912" "1.070" "1.078" "0.954" "1.107" "0.936" "0.936" "1.951" "211.6" "206.9" "193.0" "226.5" "228.1" "201.8" "234.3" "198.0" "198.1" "412.8" "" "" "" "" "" "" "" "" "" "" "190.2" "167.4" "174.6" "221.0" "188.2" "201.8" "175.4" "174.9" "177.2" "147.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9152525013652249776" "False" "High" "IsMasterProtein" "Q9H999" "Pantothenate kinase 3 OS=Homo sapiens OX=9606 GN=PANK3 PE=1 SV=1" "0.000" "False" "13.549" "12" "4" "4" "1" "370" "41.1" "6.55" "9.64" "4" "other metabolic processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf03630" "79646" "ENSG00000120137" "PANK3" "D3DQL1; hsa:79646; Q53FJ9; Q7RTX4; Q9H999" "" "Coenzyme A biosynthesis" "1" "0" "1.137" "1.161" "0.720" "1.371" "1.189" "1.003" "1.179" "1.160" "0.919" "21.4" "24.3" "24.8" "15.4" "29.3" "25.4" "21.5" "25.2" "24.8" "19.6" "" "" "" "" "" "" "" "" "" "" "19.2" "19.7" "22.5" "15.0" "24.2" "25.4" "16.1" "22.3" "22.2" "7.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827998788629081219" "False" "High" "IsMasterProtein" "Q12834" "Cell division cycle protein 20 homolog OS=Homo sapiens OX=9606 GN=CDC20 PE=1 SV=2" "0.000" "False" "13.525" "12" "6" "7" "6" "499" "54.7" "9.23" "18.26" "6" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12894" "991" "ENSG00000117399" "CDC20" "B2R6Z6; D3DPJ1; hsa:991; Q12834; Q5JUY4; Q9BW56; Q9UQI9" "Cell cycle; Regulation of sister chromatid separation at the metaphase-anaphase transition; HDAC6 interactions in the central nervous system" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Resolution of Sister Chromatid Cohesion; APC/C:Cdc20 mediated degradation of Cyclin B; Phosphorylation of Emi1; Antigen processing: Ubiquitination & Proteasome degradation; SCF-beta-TrCP mediated degradation of Emi1; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Ub-specific processing proteases; APC-Cdc20 mediated degradation of Nek2A; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Inactivation of APC/C via direct inhibition of the APC/C complex; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase" "23" "0" "0.994" "0.962" "0.915" "0.932" "0.879" "0.914" "0.870" "0.834" "1.209" "340.8" "338.8" "327.9" "311.8" "317.6" "299.5" "311.4" "296.5" "284.1" "411.9" "" "" "" "" "" "" "" "" "" "" "306.4" "274.1" "296.6" "304.4" "262.1" "299.5" "233.1" "261.9" "254.2" "147.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3901447341290801043" "False" "High" "IsMasterProtein" "Q66PJ3" "ADP-ribosylation factor-like protein 6-interacting protein 4 OS=Homo sapiens OX=9606 GN=ARL6IP4 PE=1 SV=3" "0.000" "False" "13.519" "15" "3" "4" "3" "237" "26.4" "10.86" "14.28" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf10500" "51329" "ENSG00000182196" "ARL6IP4" "A4UCR8; B3V0L0; B3V0L1; hsa:51329; Q4F966; Q504R8; Q66PJ3; Q96BI2; Q9NR05; Q9P2R9" "" "" "0" "0" "1.041" "0.976" "0.987" "1.101" "1.052" "0.932" "0.957" "0.951" "0.798" "138.4" "144.1" "135.0" "136.7" "152.4" "145.7" "129.1" "132.4" "131.7" "110.5" "" "" "" "" "" "" "" "" "" "" "124.5" "116.6" "122.2" "133.4" "125.8" "145.7" "96.6" "117.0" "117.8" "39.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "141620358562250456" "False" "High" "IsMasterProtein" "Q8NCB2" "CaM kinase-like vesicle-associated protein OS=Homo sapiens OX=9606 GN=CAMKV PE=1 SV=2" "0.000" "False" "13.518" "7" "3" "4" "3" "501" "54.3" "5.55" "14.58" "3" "other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "79012" "ENSG00000164076" "CAMKV" "A6NFD4; hsa:79012; Q6FIB8; Q8NBS8; Q8NC85; Q8NCB2; Q8NDU4; Q8WTT8; Q9BQC9; Q9H0Q5" "" "" "0" "0" "0.993" "1.076" "0.986" "1.040" "1.082" "1.101" "1.032" "1.054" "0.820" "103.4" "102.7" "111.3" "101.9" "107.6" "111.9" "113.9" "106.7" "109.0" "84.8" "" "" "" "" "" "" "" "" "" "" "93.0" "83.1" "100.6" "99.5" "88.8" "111.9" "85.3" "94.3" "97.5" "30.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2509931178025596273" "False" "High" "IsMasterProtein" "Q5JSP0" "FYVE, RhoGEF and PH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=FGD3 PE=1 SV=1" "0.000" "False" "13.514" "6" "4" "4" "4" "725" "79.4" "6.15" "14.63" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "89846" "ENSG00000127084" "FGD3" "F8W7P2; hsa:89846; Q4VX84; Q5JSP0; Q7Z7D9; Q8N5G1" "" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "3" "0" "0.986" "1.101" "1.022" "1.010" "0.976" "1.099" "1.033" "1.006" "1.466" "464.5" "457.9" "511.2" "474.9" "469.3" "453.5" "510.3" "479.9" "467.1" "680.9" "" "" "" "" "" "" "" "" "" "" "417.6" "370.6" "462.4" "463.6" "387.3" "453.5" "382.1" "423.9" "418.0" "243.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9060974175889524872" "False" "High" "IsMasterProtein" "P23468" "Receptor-type tyrosine-protein phosphatase delta OS=Homo sapiens OX=9606 GN=PTPRD PE=1 SV=2" "0.000" "False" "13.512" "4" "4" "4" "1" "1912" "214.6" "6.57" "12.85" "4" "cell adhesion;cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf00102, Pf07679, Pf13927" "5789" "ENSG00000153707" "PTPRD" "B1ALA0; F5GWT7; hsa:5789; P23468; Q3KPJ0; Q3KPJ1; Q3KPJ2" "" "Synaptic adhesion-like molecules; Receptor-type tyrosine-protein phosphatases" "2" "0" "0.678" "1.079" "0.541" "0.802" "0.643" "0.559" "0.626" "0.456" "0.695" "26.2" "17.7" "28.2" "14.2" "21.0" "16.8" "14.6" "16.4" "11.9" "18.2" "" "" "" "" "" "" "" "" "" "" "23.5" "14.3" "25.5" "13.8" "17.3" "16.8" "10.9" "14.5" "10.7" "6.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7033934706938727348" "False" "High" "IsMasterProtein" "Q9UNY4" "Transcription termination factor 2 OS=Homo sapiens OX=9606 GN=TTF2 PE=1 SV=2" "0.000" "False" "13.493" "5" "5" "5" "5" "1162" "129.5" "8.37" "15.74" "5" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf06839" "8458" "ENSG00000116830" "TTF2" "A8K4Q2; hsa:8458; O75921; Q5T2K7; Q5VVU8; Q8N6I8; Q9UNY4" "Thyroid stimulating hormone (TSH) signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "" "2" "0" "1.042" "1.119" "0.969" "0.998" "1.139" "1.051" "0.939" "1.080" "2.450" "209.7" "218.6" "234.7" "203.1" "209.2" "238.8" "220.4" "197.0" "226.3" "513.7" "" "" "" "" "" "" "" "" "" "" "188.5" "176.9" "212.3" "198.3" "172.6" "238.8" "165.0" "174.0" "202.5" "183.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8597337933688242360" "False" "High" "IsMasterProtein" "P84243" "Histone H3.3 OS=Homo sapiens OX=9606 GN=H3-3B PE=1 SV=2" "0.000" "False" "13.492" "31" "6" "17" "3" "136" "15.3" "11.27" "54.40" "6" "cell organization and biogenesis;other biological processes" "non-structural extracellular;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "3020; 3021" "ENSG00000132475; ENSG00000163041" "H3-3A; H3-3B" "hsa:3020; hsa:3021; P06351; P33155; P84243; Q5VV55; Q5VV56; Q66I33; Q9V3W4" "Gastric cancer network 1; Histone modifications; Tumor suppressor activity of SMARCB1; Ciliary landscape; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DYRK1A involvement regarding cell proliferation in brain development; 4p16.3 copy number variation; 5q35 copy number variation" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; Chromatin modifications during the maternal to zygotic transition (MZT); RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates transcription of genes involved in differentiation of HSCs; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; Amyloid fiber formation; Formation of the beta-catenin:TCF transactivating complex; Oxidative Stress Induced Senescence; Pre-NOTCH Transcription and Translation; Senescence-Associated Secretory Phenotype (SASP); Factors involved in megakaryocyte development and platelet production; Meiotic recombination; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Condensation of Prophase Chromosomes; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "36" "3" "0.908" "0.981" "0.935" "1.010" "1.030" "0.905" "0.904" "0.833" "0.945" "644.3" "585.1" "632.2" "602.6" "650.8" "663.6" "583.2" "582.8" "536.7" "608.8" "" "" "" "" "" "" "" "" "" "" "579.3" "473.4" "571.9" "588.3" "537.0" "663.6" "436.7" "514.8" "480.2" "217.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2207555378581959897" "False" "High" "IsMasterProtein" "Q14761" "Protein tyrosine phosphatase receptor type C-associated protein OS=Homo sapiens OX=9606 GN=PTPRCAP PE=1 SV=1" "0.000" "False" "13.481" "20" "4" "4" "4" "206" "21.2" "4.55" "11.69" "4" "stress response" "plasma membrane;other membranes" "" "Pf15713" "5790" "ENSG00000213402" "PTPRCAP" "B2R512; hsa:5790; O00643; Q14761; Q6I9S6" "TNF-alpha signaling pathway" "" "1" "0" "0.983" "0.881" "0.967" "1.013" "0.934" "1.056" "0.952" "0.955" "0.855" "302.9" "297.7" "266.7" "292.9" "306.8" "282.9" "319.7" "288.5" "289.3" "258.9" "" "" "" "" "" "" "" "" "" "" "272.3" "240.9" "241.3" "285.9" "253.2" "282.9" "239.4" "254.8" "258.9" "92.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2457834817562912062" "False" "High" "IsMasterProtein" "Q9GZY8" "Mitochondrial fission factor OS=Homo sapiens OX=9606 GN=MFF PE=1 SV=1" "0.000" "False" "13.471" "12" "2" "4" "2" "342" "38.4" "8.95" "21.33" "2" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05644" "56947" "ENSG00000168958" "MFF" "hsa:56947; Q567U1; Q658R6; Q9BVZ1; Q9GZY8; Q9H690; Q9NRG8" "" "" "0" "0" "1.104" "0.916" "0.814" "1.267" "1.087" "0.992" "0.956" "0.924" "0.840" "50.6" "55.9" "46.3" "41.2" "64.1" "55.0" "50.1" "48.4" "46.7" "42.5" "" "" "" "" "" "" "" "" "" "" "45.5" "45.2" "41.9" "40.2" "52.9" "55.0" "37.5" "42.7" "41.8" "15.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1613875613327361847" "False" "High" "IsMasterProtein" "Q96G25" "Mediator of RNA polymerase II transcription subunit 8 OS=Homo sapiens OX=9606 GN=MED8 PE=1 SV=2" "0.000" "False" "13.469" "19" "4" "4" "4" "268" "29.1" "7.44" "12.18" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10232" "112950" "ENSG00000159479" "MED8" "A9IZ91; A9IZ92; hsa:112950; Q5JUY8; Q96FQ4; Q96G25" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.224" "1.050" "0.993" "1.151" "1.207" "1.305" "1.216" "1.070" "1.482" "291.8" "357.2" "306.4" "289.6" "336.0" "352.1" "380.8" "354.9" "312.4" "432.3" "" "" "" "" "" "" "" "" "" "" "262.4" "289.0" "277.2" "282.7" "277.3" "352.1" "285.1" "313.5" "279.5" "154.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7667568518827666272" "False" "High" "IsMasterProtein" "O94762" "ATP-dependent DNA helicase Q5 OS=Homo sapiens OX=9606 GN=RECQL5 PE=1 SV=2" "0.000" "False" "13.457" "6" "4" "4" "4" "991" "108.8" "8.56" "13.40" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf06959, Pf16124" "9400" "ENSG00000108469" "RECQL5" "hsa:9400; O94762; Q6P4G0; Q9H0B1; Q9P1W7; Q9UNC8" "" "" "0" "0" "1.153" "1.060" "1.092" "1.132" "1.000" "1.130" "1.027" "0.974" "1.589" "132.5" "152.8" "140.5" "144.8" "150.1" "132.6" "149.8" "136.1" "129.1" "210.7" "" "" "" "" "" "" "" "" "" "" "119.2" "123.6" "127.1" "141.3" "123.8" "132.6" "112.2" "120.2" "115.5" "75.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7526904377414410620" "False" "High" "IsMasterProtein" "Q6NXR4" "TELO2-interacting protein 2 OS=Homo sapiens OX=9606 GN=TTI2 PE=1 SV=1" "0.000" "False" "13.444" "11" "4" "4" "4" "508" "56.9" "7.09" "12.85" "4" "other biological processes" "nucleus;other cell component" "" "Pf10521" "80185" "ENSG00000129696" "TTI2" "D3DSV7; hsa:80185; Q6NXR4; Q96IM2; Q9H5N4" "" "" "0" "0" "1.038" "1.048" "0.970" "1.046" "0.900" "1.098" "0.966" "0.984" "2.142" "186.1" "193.2" "195.1" "180.6" "194.7" "167.5" "204.5" "179.7" "183.1" "398.7" "" "" "" "" "" "" "" "" "" "" "167.4" "156.4" "176.5" "176.2" "160.6" "167.5" "153.1" "158.8" "163.9" "142.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6662749909958562405" "False" "High" "IsMasterProtein" "Q99467" "CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2" "0.000" "False" "13.438" "5" "2" "3" "2" "661" "74.1" "6.43" "12.59" "2" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;cytoskeleton;nucleus" "" "Pf13855, Pf18831" "4064" "ENSG00000134061" "CD180" "B2R7Z7; hsa:4064; Q32MM5; Q99467" "" "Toll Like Receptor 4 (TLR4) Cascade" "1" "0" "0.989" "0.936" "0.897" "0.935" "0.954" "0.901" "0.972" "0.871" "0.817" "165.6" "163.7" "155.0" "148.5" "154.8" "158.0" "149.3" "161.0" "144.3" "135.3" "" "" "" "" "" "" "" "" "" "" "148.9" "132.4" "140.2" "145.0" "127.7" "158.0" "111.8" "142.2" "129.1" "48.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5474212331785371457" "False" "High" "IsMasterProtein" "Q9P2G3" "Kelch-like protein 14 OS=Homo sapiens OX=9606 GN=KLHL14 PE=1 SV=2" "0.000" "False" "13.397" "6" "3" "4" "3" "628" "70.7" "6.68" "16.14" "3" "" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "" "Pf00651, Pf01344, Pf07707" "57565" "ENSG00000197705" "KLHL14" "A6NNW1; B4DHA0; hsa:57565; Q8WU41; Q9P2G3" "" "" "0" "0" "1.200" "1.229" "1.140" "1.118" "1.301" "1.350" "1.114" "1.165" "1.243" "54.4" "65.3" "66.8" "62.0" "60.8" "70.8" "73.4" "60.5" "63.3" "67.6" "" "" "" "" "" "" "" "" "" "" "48.9" "52.8" "60.4" "60.5" "50.2" "70.8" "54.9" "53.5" "56.7" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552145293122951673" "False" "High" "IsMasterProtein" "Q96P48" "Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARAP1 PE=1 SV=3" "0.000" "False" "13.378" "4" "5" "5" "5" "1450" "162.1" "6.23" "12.74" "5" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00536, Pf00620, Pf00788, Pf01412" "116985" "ENSG00000186635" "ARAP1" "A3KLL7; B2RTS2; hsa:116985; O94879; Q4LDD5; Q59FI7; Q6PHS3; Q8WU51; Q96HP6; Q96L71; Q96P48" "" "PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1; RHOA GTPase cycle; RAC1 GTPase cycle; CDC42 GTPase cycle" "4" "0" "0.998" "0.983" "0.951" "1.018" "1.013" "1.029" "0.876" "0.926" "3.611" "280.7" "280.2" "275.9" "266.8" "285.7" "284.4" "288.8" "245.9" "259.9" "1013.4" "" "" "" "" "" "" "" "" "" "" "252.4" "226.8" "249.6" "260.4" "235.8" "284.4" "216.2" "217.2" "232.6" "361.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3341461915485741514" "False" "High" "IsMasterProtein" "Q9HC36" "rRNA methyltransferase 3, mitochondrial OS=Homo sapiens OX=9606 GN=MRM3 PE=1 SV=2" "0.000" "False" "13.357" "7" "4" "6" "4" "420" "47.0" "8.73" "16.37" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588" "55178" "ENSG00000171861" "MRM3" "hsa:55178; Q53GN1; Q86VC3; Q96F76; Q9HC36; Q9NVQ5" "" "rRNA modification in the mitochondrion" "1" "0" "0.925" "0.995" "0.834" "0.935" "1.140" "0.895" "0.889" "0.880" "0.813" "333.4" "308.5" "331.6" "278.1" "311.5" "380.0" "298.2" "296.4" "293.5" "271.1" "" "" "" "" "" "" "" "" "" "" "299.7" "249.6" "300.0" "271.4" "257.1" "380.0" "223.3" "261.8" "262.6" "96.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605379253823960098" "False" "High" "IsMasterProtein" "Q96Q83" "Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 OS=Homo sapiens OX=9606 GN=ALKBH3 PE=1 SV=1" "0.000" "False" "13.350" "14" "4" "5" "4" "286" "33.4" "8.40" "18.74" "4" "cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf13532" "221120" "ENSG00000166199" "ALKBH3" "A6NDJ1; Q3SYI0; Q6NX57; Q96BU8; Q96Q83" "Direct reversal repair; 11p11.2 copy number variation syndrome" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "0.927" "1.028" "0.961" "0.966" "0.943" "0.904" "0.935" "0.979" "0.793" "596.3" "552.9" "613.1" "573.0" "576.1" "562.6" "539.1" "557.8" "584.0" "472.8" "" "" "" "" "" "" "" "" "" "" "536.2" "447.4" "554.5" "559.3" "475.4" "562.6" "403.7" "492.7" "522.6" "168.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7273003467290879098" "False" "High" "IsMasterProtein" "Q9UNE7" "E3 ubiquitin-protein ligase CHIP OS=Homo sapiens OX=9606 GN=STUB1 PE=1 SV=2" "0.000" "False" "13.343" "9" "3" "6" "3" "303" "34.8" "5.87" "16.06" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf04564, Pf12895, Pf18391" "10273" "ENSG00000103266" "STUB1" "A2IDB9; O60526; Q969U2; Q9HBT1; Q9UNE7" "Androgen receptor signaling pathway; Parkin-ubiquitin proteasomal system pathway; HDAC6 interactions in the central nervous system" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of RUNX2 expression and activity; Regulation of PTEN stability and activity; Regulation of necroptotic cell death; Downregulation of ERBB2 signaling; Regulation of TNFR1 signaling; Downregulation of TGF-beta receptor signaling" "11" "0" "0.945" "0.987" "0.892" "0.906" "0.874" "1.057" "0.925" "0.891" "2.130" "205.8" "194.6" "203.2" "183.7" "186.4" "179.9" "217.5" "190.5" "183.5" "438.5" "" "" "" "" "" "" "" "" "" "" "185.1" "157.5" "183.8" "179.3" "153.8" "179.9" "162.9" "168.2" "164.2" "156.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6875111383431957192" "False" "High" "IsMasterProtein" "Q8IYW5" "E3 ubiquitin-protein ligase RNF168 OS=Homo sapiens OX=9606 GN=RNF168 PE=1 SV=1" "0.000" "False" "13.268" "6" "3" "4" "3" "571" "65.0" "7.96" "14.62" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097" "165918" "ENSG00000163961" "RNF168" "hsa:165918; Q8IYW5; Q8NA67; Q96NS4" "ATM signaling in development and disease ; 3q29 copy number variation syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Processing of DNA double-strand break ends; SUMOylation of DNA damage response and repair proteins; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; G2/M DNA damage checkpoint; Nonhomologous End-Joining (NHEJ)" "8" "0" "1.110" "0.971" "1.097" "1.074" "1.224" "0.858" "0.809" "1.114" "1.240" "30.7" "34.1" "29.8" "33.7" "33.0" "37.6" "26.4" "24.9" "34.2" "38.1" "" "" "" "" "" "" "" "" "" "" "27.6" "27.6" "27.0" "32.9" "27.2" "37.6" "19.7" "22.0" "30.6" "13.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-512652790618625432" "False" "High" "IsMasterProtein" "P40259" "B-cell antigen receptor complex-associated protein beta chain OS=Homo sapiens OX=9606 GN=CD79B PE=1 SV=1" "0.000" "False" "13.255" "21" "3" "5" "3" "229" "26.0" "5.92" "18.07" "3" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf07686" "974" "ENSG00000007312" "CD79B" "hsa:974; P40259; Q53FS2; Q9BU06" "B cell receptor signaling pathway" "CD22 mediated BCR regulation; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "4" "0" "0.977" "0.848" "0.936" "0.989" "1.141" "1.012" "1.058" "0.866" "0.898" "361.4" "353.2" "306.6" "338.2" "357.4" "412.6" "365.7" "382.3" "313.1" "324.6" "" "" "" "" "" "" "" "" "" "" "325.0" "285.8" "277.3" "330.1" "294.9" "412.6" "273.8" "337.7" "280.2" "115.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9146953398004624321" "False" "High" "IsMasterProtein" "Q00613" "Heat shock factor protein 1 OS=Homo sapiens OX=9606 GN=HSF1 PE=1 SV=1" "0.000" "False" "13.254" "8" "4" "5" "4" "529" "57.2" "5.19" "13.37" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00447, Pf06546" "3297" "ENSG00000185122; ENSG00000284774" "HSF1" "A8K4L0; A8MW26; hsa:3297; Q00613; Q53XT4" "10q11.21q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Regulation of HSF1-mediated heat shock response; Attenuation phase; Aggrephagy; HSF1 activation" "7" "0" "1.139" "0.988" "1.037" "1.088" "0.974" "1.115" "1.075" "1.056" "3.063" "319.5" "363.8" "315.6" "331.4" "347.6" "311.1" "356.1" "343.5" "337.4" "978.5" "" "" "" "" "" "" "" "" "" "" "287.2" "294.4" "285.5" "323.5" "286.8" "311.1" "266.6" "303.4" "301.9" "349.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2927225253202889871" "False" "High" "IsMasterProtein" "P20701" "Integrin alpha-L OS=Homo sapiens OX=9606 GN=ITGAL PE=1 SV=3" "0.000" "False" "13.245" "4" "5" "5" "5" "1170" "128.7" "5.63" "16.40" "5" "cell adhesion;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00357, Pf01839, Pf08441, Pf20805" "3683" "ENSG00000005844" "ITGAL" "hsa:3683; O43746; P20701; Q45H73; Q96HB1; Q9UBC8" "Integrin-mediated cell adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Acute viral myocarditis; Cells and molecules involved in local acute inflammatory response ; Leukocyte-intrinsic Hippo pathway functions; CCL18 signaling pathway" "Integrin cell surface interactions; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Neutrophil degranulation; RUNX3 Regulates Immune Response and Cell Migration" "11" "0" "1.012" "0.855" "0.960" "1.077" "0.873" "1.140" "0.931" "0.948" "0.790" "61.4" "62.1" "52.4" "58.9" "66.1" "53.6" "70.0" "57.1" "58.2" "48.5" "" "" "" "" "" "" "" "" "" "" "55.2" "50.3" "47.4" "57.5" "54.5" "53.6" "52.4" "50.5" "52.0" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1870443060398404245" "False" "High" "IsMasterProtein" "Q9H0N5" "Pterin-4-alpha-carbinolamine dehydratase 2 OS=Homo sapiens OX=9606 GN=PCBD2 PE=1 SV=4" "0.000" "False" "13.230" "31" "4" "6" "3" "130" "14.4" "9.11" "21.90" "4" "other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf01329" "84105" "ENSG00000132570" "PCBD2" "hsa:84105; Q8TD40; Q9H0N5" "" "" "0" "1" "0.898" "0.948" "0.851" "0.892" "0.856" "0.963" "0.941" "0.846" "0.780" "255.6" "229.6" "242.4" "217.5" "227.9" "218.9" "246.2" "240.5" "216.3" "199.3" "" "" "" "" "" "" "" "" "" "" "229.8" "185.8" "219.3" "212.3" "188.1" "218.9" "184.3" "212.4" "193.5" "71.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5291846979308804894" "False" "High" "IsMasterProtein" "O95182" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Homo sapiens OX=9606 GN=NDUFA7 PE=1 SV=3" "0.000" "False" "13.225" "34" "4" "6" "4" "113" "12.5" "10.18" "20.06" "4" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "transporter activity;other molecular function" "Pf07347" "4701" "ENSG00000267855" "NDUFA7" "hsa:4701; O95182" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.951" "0.949" "1.110" "1.096" "1.101" "1.193" "1.062" "1.103" "0.593" "184.2" "175.3" "174.8" "204.5" "201.9" "202.9" "219.8" "195.6" "203.2" "109.3" "" "" "" "" "" "" "" "" "" "" "165.6" "141.8" "158.1" "199.6" "166.6" "202.9" "164.5" "172.7" "181.8" "39.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "255349237203839233" "False" "High" "IsMasterProtein" "Q9Y2Y1" "DNA-directed RNA polymerase III subunit RPC10 OS=Homo sapiens OX=9606 GN=POLR3K PE=1 SV=3" "0.000" "False" "13.215" "44" "3" "3" "3" "108" "12.3" "7.83" "14.85" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "51728" "ENSG00000161980" "POLR3K" "hsa:51728; Q1W6H4; Q96S35; Q9Y2Y1" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.821" "0.923" "0.949" "0.946" "0.906" "0.869" "1.028" "0.904" "0.746" "127.1" "104.4" "117.3" "120.6" "120.3" "115.2" "110.5" "130.7" "115.0" "94.8" "" "" "" "" "" "" "" "" "" "" "114.3" "84.5" "106.1" "117.7" "99.2" "115.2" "82.7" "115.4" "102.9" "33.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2874165042467263127" "False" "High" "IsMasterProtein" "Q6PJG6" "BRCA1-associated ATM activator 1 OS=Homo sapiens OX=9606 GN=BRAT1 PE=1 SV=2" "0.000" "False" "13.198" "9" "4" "4" "4" "821" "88.1" "5.27" "13.82" "4" "cell cycle OR cell proliferation;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "Pf02985" "221927" "ENSG00000106009" "BRAT1" "A4D200; C9JY24; hsa:221927; Q6PJG6; Q8IW85; Q8IZ43; Q8WVR8; Q96IV9; Q9H7J8; Q9UFA3" "" "" "0" "0" "1.003" "0.936" "0.922" "1.110" "1.210" "1.145" "1.017" "1.091" "1.332" "107.0" "107.3" "100.1" "98.7" "118.8" "129.5" "122.4" "108.8" "116.7" "142.5" "" "" "" "" "" "" "" "" "" "" "96.2" "86.8" "90.5" "96.3" "98.0" "129.5" "91.7" "96.1" "104.4" "50.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8376018715288755929" "False" "High" "IsMasterProtein" "O95249" "Golgi SNAP receptor complex member 1 OS=Homo sapiens OX=9606 GN=GOSR1 PE=1 SV=1" "0.000" "False" "13.197" "16" "4" "4" "4" "250" "28.6" "9.42" "14.91" "4" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf12352" "9527" "ENSG00000108587" "GOSR1" "hsa:9527; J3KST5; O75392; O95249" "" "COPI-mediated anterograde transport; Intra-Golgi traffic" "2" "0" "0.870" "0.843" "0.836" "0.980" "0.870" "0.822" "0.826" "0.950" "0.752" "319.2" "277.8" "269.0" "267.0" "312.7" "277.8" "262.4" "263.8" "303.3" "240.2" "" "" "" "" "" "" "" "" "" "" "287.0" "224.8" "243.3" "260.6" "258.0" "277.8" "196.5" "233.0" "271.4" "85.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4812205563963537221" "False" "High" "IsMasterProtein" "Q9BSH5" "Haloacid dehalogenase-like hydrolase domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HDHD3 PE=1 SV=1" "0.000" "False" "13.195" "21" "4" "5" "4" "251" "28.0" "6.71" "21.91" "4" "" "nucleus;other cell component" "" "Pf00702" "81932" "ENSG00000119431" "HDHD3" "B2RD47; hsa:81932; Q9BSH5" "" "" "0" "0" "1.008" "0.949" "0.969" "0.990" "0.946" "1.060" "1.001" "0.919" "1.048" "345.2" "348.1" "327.5" "334.6" "341.7" "326.6" "366.0" "345.4" "317.1" "361.8" "" "" "" "" "" "" "" "" "" "" "310.4" "281.7" "296.2" "326.6" "282.0" "326.6" "274.1" "305.1" "283.7" "129.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6548479852001098502" "False" "High" "IsMasterProtein" "P10253" "Lysosomal alpha-glucosidase OS=Homo sapiens OX=9606 GN=GAA PE=1 SV=4" "0.000" "False" "13.188" "7" "4" "4" "4" "952" "105.3" "6.00" "11.20" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00088, Pf01055, Pf13802, Pf21365" "2548" "ENSG00000171298; ENSG00000291507" "GAA" "hsa:2548; P10253; Q09GN4; Q14351; Q16302; Q8IWE7" "" "Neutrophil degranulation; Glycogen breakdown (glycogenolysis); Glycogen storage disease type II (GAA)" "3" "0" "1.040" "0.965" "1.036" "1.053" "1.081" "1.146" "0.935" "0.958" "0.772" "113.0" "117.5" "109.0" "117.0" "119.0" "122.1" "129.5" "105.7" "108.2" "87.2" "" "" "" "" "" "" "" "" "" "" "101.6" "95.1" "98.6" "114.2" "98.2" "122.1" "96.9" "93.3" "96.8" "31.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "484436176042567230" "False" "High" "IsMasterProtein" "P02686" "Myelin basic protein OS=Homo sapiens OX=9606 GN=MBP PE=1 SV=3" "0.000" "False" "13.185" "13" "2" "3" "2" "304" "33.1" "9.79" "17.35" "2" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01669" "4155" "ENSG00000197971" "MBP" "A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4; hsa:4155; P02686; Q15337; Q15338; Q15339; Q15340; Q59GX3; Q65ZS4; Q6AI64; Q6FH37; Q6FI04; Q6PK23" "Neural crest differentiation; Glial cell differentiation; Spinal cord injury; Interleukin-1 (IL-1) structural pathway; MECP2 and associated Rett syndrome; MAPK cascade; Complement system in neuronal development and plasticity; Opioid receptor pathways; Cell lineage map for neuronal differentiation" "EGR2 and SOX10-mediated initiation of Schwann cell myelination" "10" "0" "0.994" "1.011" "1.077" "0.975" "1.016" "1.071" "1.016" "1.131" "0.864" "139.4" "138.6" "141.0" "150.1" "136.0" "141.7" "149.3" "141.7" "157.6" "120.4" "" "" "" "" "" "" "" "" "" "" "125.4" "112.1" "127.6" "146.5" "112.2" "141.7" "111.8" "125.2" "141.1" "43.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4597913287802266182" "False" "High" "IsMasterProtein" "O60921" "Checkpoint protein HUS1 OS=Homo sapiens OX=9606 GN=HUS1 PE=1 SV=1" "0.000" "False" "13.170" "16" "4" "4" "4" "280" "31.7" "6.84" "16.11" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04005" "3364" "ENSG00000136273" "HUS1" "B4DFI9; hsa:3364; O60921" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Activation of ATR in response to replication stress; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "8" "0" "1.077" "0.938" "1.072" "1.197" "0.991" "1.139" "1.075" "1.063" "0.887" "160.0" "172.3" "150.1" "171.4" "191.5" "158.5" "182.2" "172.0" "170.0" "141.9" "" "" "" "" "" "" "" "" "" "" "143.8" "139.4" "135.7" "167.3" "158.0" "158.5" "136.5" "152.0" "152.1" "50.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1871023154594230453" "False" "High" "IsMasterProtein" "Q14241" "Elongin-A OS=Homo sapiens OX=9606 GN=ELOA PE=1 SV=3" "0.000" "False" "13.169" "8" "6" "6" "6" "772" "87.2" "9.57" "17.96" "6" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06881, Pf08711" "6924" "ENSG00000011007" "ELOA" "B2R7Q8; hsa:6924; Q14241; Q8IXH1" "VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; 10q11.21q11.23 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "14" "0" "0.945" "1.040" "0.869" "0.991" "1.173" "0.915" "0.926" "0.925" "1.602" "548.2" "518.2" "570.1" "476.4" "543.4" "643.1" "501.8" "507.8" "506.9" "878.2" "" "" "" "" "" "" "" "" "" "" "492.9" "419.3" "515.7" "465.0" "448.4" "643.1" "375.7" "448.5" "453.5" "313.5" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7903736519056340786" "False" "High" "IsMasterProtein" "P53985" "Monocarboxylate transporter 1 OS=Homo sapiens OX=9606 GN=SLC16A1 PE=1 SV=3" "0.000" "False" "13.163" "9" "4" "4" "4" "500" "53.9" "8.66" "13.34" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity;other molecular function" "" "6566" "ENSG00000155380; ENSG00000281917" "SLC16A1" "hsa:6566; P53985; Q49A45; Q5T8R6; Q9NSJ9" "Photodynamic therapy-induced HIF-1 survival signaling; Fragile X syndrome; Glucose metabolism in triple-negative breast cancer cells" "Basigin interactions; Pyruvate metabolism; Aspirin ADME; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "8" "0" "1.153" "1.057" "1.076" "1.119" "1.137" "1.051" "1.126" "1.289" "0.777" "333.0" "384.0" "352.0" "358.3" "372.5" "378.7" "350.0" "375.0" "429.4" "258.7" "" "" "" "" "" "" "" "" "" "" "299.4" "310.7" "318.4" "349.7" "307.4" "378.7" "262.0" "331.2" "384.2" "92.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1954623923501006519" "False" "High" "IsMasterProtein" "Q8TBE9" "N-acylneuraminate-9-phosphatase OS=Homo sapiens OX=9606 GN=NANP PE=1 SV=1" "0.000" "False" "13.154" "22" "4" "4" "4" "248" "27.8" "6.40" "13.96" "4" "other metabolic processes" "cytosol" "other molecular function" "Pf00702" "140838" "ENSG00000170191" "NANP" "B3KP12; hsa:140838; Q5JYN8; Q8TBE9; Q8TE97; Q9Y3N0" "" "Sialic acid metabolism" "1" "0" "0.957" "1.151" "0.905" "1.029" "1.017" "0.906" "0.945" "1.078" "0.894" "288.8" "276.3" "332.5" "261.3" "297.1" "293.7" "261.6" "272.9" "311.4" "258.3" "" "" "" "" "" "" "" "" "" "" "259.6" "223.6" "300.8" "255.1" "245.2" "293.7" "195.9" "241.1" "278.6" "92.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4396257609671438072" "False" "High" "IsMasterProtein" "Q8IZL8" "Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens OX=9606 GN=PELP1 PE=1 SV=2" "0.000" "False" "13.149" "6" "3" "3" "3" "1130" "119.6" "4.34" "15.03" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08166, Pf08167" "27043" "ENSG00000141456" "PELP1" "hsa:27043; O15450; Q5EGN3; Q6NTE6; Q8IZL8; Q96FT1; Q9BU60" "" "Major pathway of rRNA processing in the nucleolus and cytosol; PTK6 Expression" "2" "0" "0.892" "0.895" "0.845" "0.877" "0.852" "0.793" "0.824" "0.760" "0.622" "134.0" "119.6" "119.9" "113.2" "117.4" "114.2" "106.2" "110.5" "101.8" "83.3" "" "" "" "" "" "" "" "" "" "" "120.5" "96.8" "108.5" "110.5" "96.9" "114.2" "79.5" "97.6" "91.1" "29.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8787023427386069087" "False" "High" "IsMasterProtein" "P53365" "Arfaptin-2 OS=Homo sapiens OX=9606 GN=ARFIP2 PE=1 SV=1" "0.000" "False" "13.145" "15" "4" "4" "3" "341" "37.8" "6.04" "14.24" "4" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf06456" "23647" "ENSG00000132254" "ARFIP2" "B4DX86; B4E306; D3DQT5; hsa:23647; P53365" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.881" "1.179" "1.023" "1.059" "1.033" "1.015" "1.138" "1.077" "1.303" "89.6" "79.0" "105.6" "91.6" "94.9" "92.5" "91.0" "101.9" "96.5" "116.8" "" "" "" "" "" "" "" "" "" "" "80.5" "63.9" "95.6" "89.4" "78.3" "92.5" "68.1" "90.0" "86.4" "41.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665594491149638353" "False" "High" "IsMasterProtein" "P12931" "Proto-oncogene tyrosine-protein kinase Src OS=Homo sapiens OX=9606 GN=SRC PE=1 SV=3" "0.000" "False" "13.124" "8" "5" "9" "2" "536" "59.8" "7.42" "23.73" "5" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "6714" "ENSG00000197122; ENSG00000291971" "SRC" "E1P5V4; hsa:6714; P12931; Q76P87; Q86VB9; Q9H5A8" "Androgen receptor signaling pathway; Angiogenesis; Integrin-mediated cell adhesion; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; Thymic stromal lymphopoietin (TSLP) signaling pathway; Glioblastoma signaling pathways; AGE/RAGE pathway; Interleukin-11 signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Aryl hydrocarbon receptor pathway; Bladder cancer; IL-3 signaling pathway; Aryl hydrocarbon receptor pathway; Pregnane X receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; TGF-beta signaling pathway; Amplification and expansion of oncogenic pathways as metastatic traits; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; Robo4 and VEGF signaling pathways crosstalk; Fibrin complement receptor 3 signaling pathway; MET in type 1 papillary renal cell carcinoma; Acute viral myocarditis; NRF2-ARE regulation; EGF/EGFR signaling pathway; Relationship between inflammation, COX-2 and EGFR; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Netrin-UNC5B signaling pathway; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; TROP2 regulatory signaling; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; EPO receptor signaling; Notch signaling pathway; ErbB signaling pathway" "G alpha (i) signalling events; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; PIP3 activates AKT signaling; Signaling by BRAF and RAF1 fusions; Regulation of RUNX3 expression and activity; RHOU GTPase cycle; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; DCC mediated attractive signaling; Downstream signal transduction; Signaling by ERBB2; Nuclear signaling by ERBB4; RAF activation; GAB1 signalosome; MET activates PTK2 signaling; Signaling by CSF1 (M-CSF) in myeloid cells; RUNX2 regulates osteoblast differentiation; Long-term potentiation; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; InlA-mediated entry of Listeria monocytogenes into host cells; Regulation of commissural axon pathfinding by SLIT and ROBO; Netrin mediated repulsion signals; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins; Activated NTRK2 signals through FYN; Downregulation of ERBB4 signaling; Regulation of RUNX1 Expression and Activity; Activated NTRK3 signals through PI3K" "90" "0" "0.974" "1.028" "0.820" "0.964" "0.867" "0.919" "0.802" "0.915" "0.689" "718.4" "699.4" "738.3" "589.4" "692.3" "623.1" "660.6" "575.9" "657.4" "495.1" "" "" "" "" "" "" "" "" "" "" "645.9" "566.0" "667.8" "575.4" "571.3" "623.1" "494.6" "508.6" "588.2" "176.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "408480103546989940" "False" "High" "IsMasterProtein" "Q9Y4C1" "Lysine-specific demethylase 3A OS=Homo sapiens OX=9606 GN=KDM3A PE=1 SV=4" "0.000" "False" "13.113" "4" "5" "5" "4" "1321" "147.2" "8.07" "14.63" "5" "cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "55818" "ENSG00000115548" "KDM3A" "D6W5M3; hsa:55818; Q53S72; Q68D47; Q68UT9; Q6N050; Q8IY08; Q9Y4C1" "Thermogenesis; Male infertility; Vitamin D-sensitive calcium signaling in depression" "HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "5" "0" "1.113" "0.989" "0.924" "1.221" "1.139" "1.208" "1.003" "1.060" "1.165" "149.0" "165.9" "147.3" "137.6" "181.9" "169.7" "180.0" "149.4" "158.0" "173.6" "" "" "" "" "" "" "" "" "" "" "134.0" "134.2" "133.3" "134.4" "150.1" "169.7" "134.8" "131.9" "141.4" "62.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "117262061430317364" "False" "High" "IsMasterProtein" "Q96T88" "E3 ubiquitin-protein ligase UHRF1 OS=Homo sapiens OX=9606 GN=UHRF1 PE=1 SV=1" "0.000" "False" "13.107" "6" "4" "5" "4" "793" "89.8" "7.56" "18.66" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00240, Pf00628, Pf02182, Pf12148" "29128" "ENSG00000276043" "UHRF1" "A0JBR2; A8K024; B2RBA9; Q2HIX7; Q8J022; Q96T88; Q9H6S6; Q9P115; Q9P1U7" "Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma" "Chromatin modifications during the maternal to zygotic transition (MZT); DNA methylation" "4" "0" "1.037" "1.112" "0.815" "0.953" "1.013" "0.946" "0.888" "0.995" "6.490" "87.7" "91.0" "97.6" "71.5" "83.6" "88.8" "83.0" "77.9" "87.3" "569.4" "" "" "" "" "" "" "" "" "" "" "78.9" "73.6" "88.3" "69.8" "69.0" "88.8" "62.1" "68.8" "78.1" "203.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3953931010856732739" "False" "High" "IsMasterProtein" "P16104" "Histone H2AX OS=Homo sapiens OX=9606 GN=H2AX PE=1 SV=2" "0.000" "False" "13.100" "27" "5" "15" "2" "143" "15.1" "10.74" "40.86" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125, Pf16211" "3014" "ENSG00000188486" "H2AX" "hsa:3014; P16104; Q4ZGJ7; Q6IAS5" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Proteasome degradation; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; DNA repair pathways, full network; 5q35 copy number variation; DNA damage response" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Amyloid fiber formation; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Oxidative Stress Induced Senescence; Senescence-Associated Secretory Phenotype (SASP); Processing of DNA double-strand break ends; RMTs methylate histone arginines; Meiotic synapsis; Transcriptional regulation by small RNAs; Deposition of new CENPA-containing nucleosomes at the centromere; B-WICH complex positively regulates rRNA expression; Formation of the beta-catenin:TCF transactivating complex; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; G2/M DNA damage checkpoint; Chromatin modifications during the maternal to zygotic transition (MZT); RNA Polymerase I Promoter Escape; Meiotic recombination; Inhibition of DNA recombination at telomere; Recognition and association of DNA glycosylase with site containing an affected purine; Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Cleavage of the damaged purine; SIRT1 negatively regulates rRNA expression; PRC2 methylates histones and DNA; Assembly of the ORC complex at the origin of replication; Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3; Defective pyroptosis; Packaging Of Telomere Ends; Condensation of Prophase Chromosomes; DNA Damage/Telomere Stress Induced Senescence; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression; DNA methylation; Nonhomologous End-Joining (NHEJ); RNA Polymerase I Promoter Opening; Transcriptional regulation of granulopoiesis; Replacement of protamines by nucleosomes in the male pronucleus" "47" "3" "0.910" "0.896" "0.829" "0.993" "0.962" "0.948" "0.896" "0.854" "0.951" "1131.7" "1029.7" "1013.9" "938.2" "1123.4" "1089.0" "1073.2" "1014.2" "966.3" "1075.8" "" "" "" "" "" "" "" "" "" "" "1017.5" "833.2" "917.1" "915.8" "927.1" "1089.0" "803.6" "895.8" "864.6" "384.0" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3119089922168410835" "False" "High" "IsMasterProtein" "P10606" "Cytochrome c oxidase subunit 5B, mitochondrial OS=Homo sapiens OX=9606 GN=COX5B PE=1 SV=2" "0.000" "False" "13.079" "23" "3" "5" "3" "129" "13.7" "8.81" "15.71" "3" "other metabolic processes;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf01215" "1329" "ENSG00000135940; ENSG00000291596" "COX5B" "hsa:1329; P10606; Q53YB7; Q96J18; Q99610" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Mitochondrial protein degradation; Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "8" "0" "0.885" "0.975" "0.925" "0.921" "0.971" "0.893" "1.067" "0.946" "0.695" "432.0" "382.2" "421.1" "399.6" "397.8" "419.6" "385.9" "460.9" "408.5" "300.2" "" "" "" "" "" "" "" "" "" "" "388.4" "309.3" "380.9" "390.0" "328.3" "419.6" "289.0" "407.1" "365.5" "107.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4000962258629935056" "False" "High" "IsMasterProtein" "P62847" "Small ribosomal subunit protein eS24 OS=Homo sapiens OX=9606 GN=RPS24 PE=1 SV=1" "0.000" "False" "13.071" "25" "3" "5" "3" "133" "15.4" "10.78" "16.35" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01282" "6229" "ENSG00000138326" "RPS24" "E7EPK6; hsa:6229; P16632; P62847; Q5T0P7; Q5T0P8; Q7Z3D1" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-2 modulates host translation machinery; SARS-CoV-1 modulates host translation machinery" "19" "0" "1.024" "0.981" "0.982" "0.970" "1.071" "0.994" "0.929" "1.074" "1.043" "294.5" "301.7" "289.0" "289.1" "285.7" "315.3" "292.7" "273.7" "316.3" "307.2" "" "" "" "" "" "" "" "" "" "" "264.8" "244.1" "261.4" "282.2" "235.8" "315.3" "219.2" "241.8" "283.1" "109.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6934438525806986251" "False" "High" "IsMasterProtein" "Q7Z7K0" "COX assembly mitochondrial protein homolog OS=Homo sapiens OX=9606 GN=CMC1 PE=1 SV=1" "0.000" "False" "13.068" "40" "4" "5" "4" "106" "12.5" "8.63" "18.63" "4" "" "mitochondrion" "other molecular function" "Pf08583" "152100" "ENSG00000187118" "CMC1" "hsa:152100; Q68DJ7; Q7Z7K0" "Mitochondrial complex IV assembly" "" "1" "0" "0.988" "1.076" "0.962" "0.960" "1.023" "0.875" "1.016" "0.977" "0.802" "519.6" "513.4" "559.2" "499.7" "499.0" "531.6" "454.5" "528.0" "507.9" "416.5" "" "" "" "" "" "" "" "" "" "" "467.2" "415.4" "505.8" "487.7" "411.8" "531.6" "340.3" "466.4" "454.5" "148.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1949176893953303809" "False" "High" "IsMasterProtein" "Q9NZZ3" "Charged multivesicular body protein 5 OS=Homo sapiens OX=9606 GN=CHMP5 PE=1 SV=1" "0.000" "False" "13.051" "17" "2" "5" "2" "219" "24.6" "4.83" "26.49" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf03357" "51510" "ENSG00000086065" "CHMP5" "B2RD95; B4DIR6; hsa:51510; Q5VXW2; Q96AV2; Q9HB68; Q9NYS4; Q9NZZ3; Q9Y323" "Ferroptosis" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT)" "3" "0" "1.051" "1.059" "1.021" "1.144" "1.004" "1.216" "1.142" "0.948" "0.932" "298.0" "313.1" "315.6" "304.4" "340.9" "299.3" "362.3" "340.2" "282.6" "277.8" "" "" "" "" "" "" "" "" "" "" "267.9" "253.3" "285.5" "297.1" "281.4" "299.3" "271.3" "300.5" "252.8" "99.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5741463921085592561" "False" "High" "IsMasterProtein" "O75962" "Triple functional domain protein OS=Homo sapiens OX=9606 GN=TRIO PE=1 SV=2" "0.000" "False" "13.050" "2" "4" "4" "4" "3097" "346.7" "6.37" "11.95" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00018, Pf00069, Pf00169, Pf00435, Pf00621, Pf07679, Pf13716, Pf16609" "7204" "ENSG00000038382" "TRIO" "D3DTD1; hsa:7204; O75962; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8" "Microtubule cytoskeleton regulation; Neural crest cell migration during development; Neural crest cell migration in cancer; GNAQ pathways in port-wine stain" "RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events; RHOG GTPase cycle; G alpha (q) signalling events; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOJ GTPase cycle; DCC mediated attractive signaling" "15" "0" "1.071" "1.006" "1.082" "0.905" "0.876" "1.079" "1.132" "0.981" "1.195" "49.1" "52.6" "49.4" "53.1" "44.4" "43.0" "53.0" "55.5" "48.2" "58.7" "" "" "" "" "" "" "" "" "" "" "44.1" "42.6" "44.7" "51.9" "36.7" "43.0" "39.7" "49.1" "43.1" "20.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8473772251373638669" "False" "High" "IsMasterProtein" "Q12907" "Vesicular integral-membrane protein VIP36 OS=Homo sapiens OX=9606 GN=LMAN2 PE=1 SV=1" "0.000" "False" "13.044" "12" "3" "4" "3" "356" "40.2" "6.95" "17.89" "3" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03388" "10960" "ENSG00000169223" "LMAN2" "hsa:10960; Q12907; Q53HH1" "5q35 copy number variation" "COPII-mediated vesicle transport; Cargo concentration in the ER" "3" "0" "0.923" "0.876" "0.974" "1.018" "0.887" "0.937" "0.978" "0.896" "0.665" "579.6" "534.8" "507.9" "564.3" "589.8" "514.0" "543.4" "566.6" "519.4" "385.4" "" "" "" "" "" "" "" "" "" "" "521.1" "432.7" "459.4" "550.8" "486.7" "514.0" "406.9" "500.5" "464.8" "137.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4078172975795956139" "False" "High" "IsMasterProtein" "Q7Z6V5" "tRNA-specific adenosine deaminase 2 OS=Homo sapiens OX=9606 GN=ADAT2 PE=1 SV=1" "0.000" "False" "13.043" "23" "4" "4" "4" "191" "21.0" "6.74" "14.23" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf14437" "134637" "ENSG00000189007" "ADAT2" "A6NL12; B3KWY3; hsa:134637; Q7Z327; Q7Z6V5; Q8IY39" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.001" "1.005" "0.898" "1.220" "1.009" "1.011" "1.095" "1.061" "0.977" "263.9" "264.0" "265.2" "237.1" "322.0" "266.1" "266.8" "288.9" "280.0" "257.8" "" "" "" "" "" "" "" "" "" "" "237.2" "213.6" "239.9" "231.4" "265.7" "266.1" "199.8" "255.2" "250.5" "92.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5802259196988862678" "False" "High" "IsMasterProtein" "Q9NUY8" "TBC1 domain family member 23 OS=Homo sapiens OX=9606 GN=TBC1D23 PE=1 SV=3" "0.000" "False" "13.006" "5" "2" "4" "2" "699" "78.3" "5.41" "19.51" "2" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cell component" "" "Pf00566, Pf00581, Pf19430" "55773" "ENSG00000036054" "TBC1D23" "B9A6M5; hsa:55773; Q8TCN8; Q8WUB7; Q96D90; Q9NUY8; Q9NV75" "" "" "0" "0" "1.119" "1.029" "0.964" "1.241" "1.068" "1.017" "1.214" "1.084" "1.279" "168.6" "188.8" "173.5" "162.6" "209.2" "180.1" "171.5" "204.7" "182.8" "215.7" "" "" "" "" "" "" "" "" "" "" "151.6" "152.7" "156.9" "158.7" "172.7" "180.1" "128.4" "180.8" "163.6" "77.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8588470506095453677" "False" "High" "IsMasterProtein" "P21912" "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Homo sapiens OX=9606 GN=SDHB PE=1 SV=3" "0.000" "False" "12.981" "15" "4" "4" "4" "280" "31.6" "8.76" "14.17" "4" "other metabolic processes" "plasma membrane;other membranes;mitochondrion;nucleus" "other molecular function" "Pf13085, Pf13534" "6390" "ENSG00000117118" "SDHB" "B2R545; hsa:6390; P21912; Q0QEY7; Q9NQ12" "Electron transport chain: OXPHOS system in mitochondria; Metabolic reprogramming in colon cancer; Nonalcoholic fatty liver disease; Mitochondrial complex II assembly; TCA cycle (aka Krebs or citric acid cycle)" "Respiratory electron transport; Citric acid cycle (TCA cycle)" "7" "0" "1.096" "1.067" "1.030" "1.055" "1.096" "1.014" "1.137" "1.143" "0.928" "145.8" "159.8" "155.5" "150.2" "153.8" "159.8" "147.9" "165.8" "166.6" "135.3" "" "" "" "" "" "" "" "" "" "" "131.1" "129.3" "140.7" "146.6" "126.9" "159.8" "110.7" "146.4" "149.1" "48.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1530095289376032453" "False" "High" "IsMasterProtein" "Q9HBH1" "Peptide deformylase, mitochondrial OS=Homo sapiens OX=9606 GN=PDF PE=1 SV=1" "0.000" "False" "12.966" "13" "3" "4" "3" "243" "27.0" "9.16" "14.98" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf01327" "64146" "ENSG00000258429" "PDF" "hsa:64146; Q8WUN6; Q9HBH1" "" "" "0" "0" "0.976" "1.004" "1.034" "1.089" "1.082" "1.043" "1.012" "1.118" "0.889" "105.2" "102.6" "105.6" "108.7" "114.5" "113.7" "109.6" "106.4" "117.5" "93.5" "" "" "" "" "" "" "" "" "" "" "94.5" "83.0" "95.5" "106.1" "94.5" "113.7" "82.1" "94.0" "105.1" "33.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696690186535498755" "False" "High" "IsMasterProtein" "Q9NPJ3" "Acyl-coenzyme A thioesterase 13 OS=Homo sapiens OX=9606 GN=ACOT13 PE=1 SV=1" "0.000" "False" "12.964" "21" "2" "3" "2" "140" "15.0" "9.14" "15.09" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton;mitochondrion" "other molecular function" "Pf03061" "55856" "ENSG00000112304" "ACOT13" "F5H2L4; hsa:55856; O95549; Q9NPJ3" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.952" "0.998" "0.969" "1.013" "0.966" "1.004" "1.041" "0.995" "0.783" "537.7" "512.0" "536.8" "521.1" "544.4" "519.4" "540.1" "559.5" "535.2" "421.3" "" "" "" "" "" "" "" "" "" "" "483.4" "414.3" "485.5" "508.7" "449.3" "519.4" "404.4" "494.2" "478.9" "150.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8696589814023666564" "False" "High" "IsMasterProtein" "Q13503" "Mediator of RNA polymerase II transcription subunit 21 OS=Homo sapiens OX=9606 GN=MED21 PE=1 SV=1" "0.000" "False" "12.961" "22" "2" "3" "2" "144" "15.6" "4.45" "12.04" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11221" "9412" "ENSG00000152944" "MED21" "B2R4I3; hsa:9412; Q13503; Q6IB05; Q92811" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.965" "1.073" "0.883" "0.987" "1.009" "1.031" "0.934" "0.993" "0.959" "135.5" "130.6" "145.4" "119.7" "133.7" "136.7" "139.6" "126.5" "134.5" "129.9" "" "" "" "" "" "" "" "" "" "" "121.8" "105.7" "131.5" "116.8" "110.3" "136.7" "104.5" "111.8" "120.3" "46.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3258131120717726760" "False" "High" "IsMasterProtein" "Q96EU6" "Ribosomal RNA processing protein 36 homolog OS=Homo sapiens OX=9606 GN=RRP36 PE=1 SV=1" "0.000" "False" "12.956" "18" "3" "4" "3" "259" "29.8" "10.17" "11.54" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf06102" "88745" "ENSG00000124541" "RRP36" "hsa:88745; Q96EU6; Q9BRF6; Q9P0C8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.037" "0.977" "1.109" "1.158" "0.961" "1.101" "1.062" "0.888" "0.714" "202.6" "210.0" "197.9" "224.6" "234.5" "194.6" "223.0" "215.0" "179.9" "144.5" "" "" "" "" "" "" "" "" "" "" "182.1" "169.9" "179.0" "219.2" "193.5" "194.6" "167.0" "189.9" "161.0" "51.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8652321965736247269" "False" "High" "IsMasterProtein" "Q8TCA0" "Leucine-rich repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=LRRC20 PE=1 SV=1" "0.000" "False" "12.955" "24" "4" "4" "4" "184" "20.5" "6.55" "16.73" "4" "" "" "" "Pf13855" "55222" "ENSG00000172731" "LRRC20" "hsa:55222; Q5T6D4; Q5T6D6; Q8TCA0; Q9NVA6; Q9NVG3" "" "" "0" "0" "1.189" "1.188" "1.142" "1.230" "1.121" "1.139" "1.209" "1.209" "1.017" "158.7" "188.7" "188.6" "181.3" "195.3" "178.0" "180.8" "191.9" "191.9" "161.4" "" "" "" "" "" "" "" "" "" "" "142.7" "152.7" "170.6" "177.0" "161.2" "178.0" "135.4" "169.5" "171.7" "57.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7633283186484640293" "False" "High" "IsMasterProtein" "Q06547" "GA-binding protein subunit beta-1 OS=Homo sapiens OX=9606 GN=GABPB1 PE=1 SV=2" "0.000" "False" "12.936" "7" "4" "5" "4" "395" "42.5" "4.86" "17.16" "4" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf12796" "2553" "ENSG00000104064" "GABPB1" "A8IE52; hsa:2553; Q06545; Q06547; Q12940; Q12941; Q12942; Q8IYD0" "Myometrial relaxation and contraction pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; Mitochondrial gene expression" "" "3" "0" "1.038" "1.092" "0.985" "1.041" "1.072" "1.096" "1.033" "1.032" "1.767" "614.7" "638.0" "671.1" "605.7" "639.6" "658.9" "673.9" "635.1" "634.6" "1086.1" "" "" "" "" "" "" "" "" "" "" "552.7" "516.2" "607.0" "591.3" "527.8" "658.9" "504.6" "560.9" "567.9" "387.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8656179388413657305" "False" "High" "IsMasterProtein" "O00308" "NEDD4-like E3 ubiquitin-protein ligase WWP2 OS=Homo sapiens OX=9606 GN=WWP2 PE=1 SV=2" "0.000" "False" "12.900" "5" "4" "5" "3" "870" "98.9" "7.12" "14.79" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00397, Pf00632" "11060" "ENSG00000198373" "WWP2" "A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; hsa:11060; I3RSG8; O00308; Q6ZTQ5; Q96CZ2; Q9BWN6" "" "RHOQ GTPase cycle; Regulation of PTEN stability and activity; RHOJ GTPase cycle; NOTCH3 Activation and Transmission of Signal to the Nucleus; RHOU GTPase cycle" "5" "0" "0.970" "1.161" "0.934" "1.152" "1.128" "1.014" "1.041" "1.036" "1.725" "41.8" "40.6" "48.6" "39.1" "48.2" "47.2" "42.4" "43.6" "43.3" "72.2" "" "" "" "" "" "" "" "" "" "" "37.6" "32.8" "43.9" "38.2" "39.8" "47.2" "31.8" "38.5" "38.8" "25.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7058356130293402746" "False" "High" "IsMasterProtein" "Q6ZRS2" "Helicase SRCAP OS=Homo sapiens OX=9606 GN=SRCAP PE=1 SV=3" "0.000" "False" "12.898" "1" "4" "4" "4" "3230" "343.3" "5.96" "13.31" "4" "cell organization and biogenesis;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf07529" "10847" "ENSG00000080603" "SRCAP" "B0JZA6; hsa:10847; O15026; Q6ZRS2; Q7Z744; Q9Y5L9" "Pathways affected in adenoid cystic carcinoma" "" "1" "0" "1.078" "0.954" "0.955" "1.048" "1.031" "1.036" "0.814" "0.876" "1.068" "135.6" "146.2" "129.3" "129.5" "142.1" "139.8" "140.4" "110.3" "118.8" "144.8" "" "" "" "" "" "" "" "" "" "" "121.9" "118.3" "116.9" "126.4" "117.3" "139.8" "105.1" "97.5" "106.3" "51.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1761615694951134021" "False" "High" "IsMasterProtein" "P62888" "Large ribosomal subunit protein eL30 OS=Homo sapiens OX=9606 GN=RPL30 PE=1 SV=2" "0.000" "False" "12.897" "32" "3" "7" "3" "115" "12.8" "9.63" "16.42" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6156" "ENSG00000156482" "RPL30" "B2R591; hsa:6156; P04645; P62888; Q502Z6" "Selenium metabolism and selenoproteins; Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "1.016" "1.071" "0.964" "1.061" "1.118" "1.035" "0.942" "1.027" "0.901" "412.5" "419.0" "441.9" "397.7" "437.7" "461.2" "426.9" "388.5" "423.7" "371.7" "" "" "" "" "" "" "" "" "" "" "370.9" "339.0" "399.7" "388.2" "361.2" "461.2" "319.6" "343.1" "379.1" "132.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3266136317046350400" "False" "High" "IsMasterProtein" "Q70Z53" "Protein FRA10AC1 OS=Homo sapiens OX=9606 GN=FRA10AC1 PE=1 SV=3" "0.000" "False" "12.860" "13" "5" "7" "5" "315" "37.5" "8.10" "21.93" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf09725" "118924" "ENSG00000148690" "FRA10AC1" "C9JCR4; C9JCR5; C9JMY4; hsa:118924; Q70Z49; Q70Z50; Q70Z51; Q70Z52; Q70Z53; Q8N293; Q8WVH5; Q96JQ8" "" "" "0" "0" "0.980" "1.006" "0.945" "1.021" "0.968" "0.928" "1.010" "1.007" "1.108" "867.2" "850.0" "872.7" "819.1" "885.4" "839.2" "804.4" "876.0" "873.6" "960.7" "" "" "" "" "" "" "" "" "" "" "779.7" "687.8" "789.4" "799.6" "730.7" "839.2" "602.3" "773.7" "781.7" "342.9" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9201189030336339183" "False" "High" "IsMasterProtein" "P62875" "DNA-directed RNA polymerases I, II, and III subunit RPABC5 OS=Homo sapiens OX=9606 GN=POLR2L PE=1 SV=1" "0.000" "False" "12.847" "39" "3" "5" "3" "67" "7.6" "7.77" "15.20" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01194" "5441" "ENSG00000177700" "POLR2L" "hsa:5441; P52436; P62875; Q6FHX3" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "56" "0" "1.054" "0.930" "1.081" "0.996" "0.940" "1.062" "1.057" "1.129" "1.222" "163.1" "171.9" "151.7" "176.3" "162.5" "153.3" "173.2" "172.5" "184.2" "199.4" "" "" "" "" "" "" "" "" "" "" "146.7" "139.1" "137.2" "172.1" "134.1" "153.3" "129.7" "152.3" "164.8" "71.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3328900627537449382" "False" "High" "IsMasterProtein" "Q03111" "Protein ENL OS=Homo sapiens OX=9606 GN=MLLT1 PE=1 SV=2" "0.000" "False" "12.831" "10" "5" "5" "5" "559" "62.0" "8.59" "13.30" "5" "other biological processes" "cytosol;nucleus" "other molecular function" "Pf03366, Pf17793" "4298" "ENSG00000130382" "MLLT1" "hsa:4298; Q03111; Q14768" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "0.973" "0.934" "1.052" "1.051" "0.967" "1.058" "1.045" "0.972" "1.278" "438.6" "427.0" "409.9" "461.2" "460.8" "424.1" "464.1" "458.2" "426.3" "560.7" "" "" "" "" "" "" "" "" "" "" "394.4" "345.5" "370.8" "450.2" "380.3" "424.1" "347.5" "404.7" "381.5" "200.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7992266646399474025" "False" "High" "IsMasterProtein" "Q9Y605" "MORF4 family-associated protein 1 OS=Homo sapiens OX=9606 GN=MRFAP1 PE=1 SV=1" "0.000" "False" "12.817" "33" "3" "3" "3" "127" "14.6" "4.70" "14.34" "3" "" "nucleus;other cell component" "" "Pf15155" "93621" "ENSG00000179010" "MRFAP1" "B3KVT2; D3DVT3; hsa:93621; Q9Y605" "" "" "0" "0" "0.989" "1.102" "0.920" "1.034" "1.151" "1.061" "1.037" "1.015" "1.054" "223.9" "221.5" "246.7" "206.0" "231.5" "257.7" "237.6" "232.2" "227.3" "235.9" "" "" "" "" "" "" "" "" "" "" "201.3" "179.2" "223.1" "201.1" "191.1" "257.7" "177.9" "205.1" "203.4" "84.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7855128710481582123" "False" "High" "IsMasterProtein" "P50238" "Cysteine-rich protein 1 OS=Homo sapiens OX=9606 GN=CRIP1 PE=1 SV=3" "0.000" "False" "12.807" "31" "3" "11" "3" "77" "8.5" "8.75" "35.20" "3" "stress response;developmental processes;signal transduction;other biological processes" "other cell component" "other molecular function" "Pf00412" "1396" "ENSG00000213145" "CRIP1" "H3BPI2; hsa:1396; P50238; Q13628; Q53XY7; Q96J34" "" "" "0" "0" "0.893" "0.975" "0.993" "0.934" "0.987" "0.951" "0.981" "0.861" "0.811" "767.1" "684.9" "747.7" "761.3" "716.3" "756.9" "729.2" "752.7" "660.6" "621.8" "" "" "" "" "" "" "" "" "" "" "689.7" "554.2" "676.3" "743.1" "591.1" "756.9" "546.0" "664.8" "591.1" "222.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2809797377402095157" "False" "High" "IsMasterProtein" "P42785" "Lysosomal Pro-X carboxypeptidase OS=Homo sapiens OX=9606 GN=PRCP PE=1 SV=1" "0.000" "False" "12.799" "8" "4" "4" "4" "496" "55.8" "7.21" "13.76" "4" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05577" "5547" "ENSG00000137509" "PRCP" "A8MU24; B2R7B7; B3KRK5; B5BU34; hsa:5547; P42785" "" "Intrinsic Pathway of Fibrin Clot Formation; Neutrophil degranulation" "2" "0" "1.047" "1.044" "0.964" "1.075" "1.008" "1.064" "1.057" "1.039" "0.859" "484.5" "507.2" "505.6" "467.2" "520.7" "488.6" "515.3" "511.9" "503.6" "416.2" "" "" "" "" "" "" "" "" "" "" "435.6" "410.4" "457.3" "456.0" "429.7" "488.6" "385.8" "452.2" "450.6" "148.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5647730209445312513" "False" "High" "IsMasterProtein" "Q9BWT3" "Poly(A) polymerase gamma OS=Homo sapiens OX=9606 GN=PAPOLG PE=1 SV=2" "0.000" "False" "12.796" "5" "4" "5" "1" "736" "82.8" "9.14" "15.48" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf04926, Pf04928, Pf20750" "64895" "ENSG00000115421" "PAPOLG" "B2RBH4; hsa:64895; Q59G05; Q969N1; Q9BWT3; Q9H8L2; Q9HAD0" "" "" "0" "0" "1.008" "0.975" "0.953" "1.058" "1.372" "1.299" "1.166" "1.246" "6.876" "19.0" "19.2" "18.6" "18.1" "20.1" "26.1" "24.7" "22.2" "23.7" "130.8" "" "" "" "" "" "" "" "" "" "" "17.1" "15.5" "16.8" "17.7" "16.6" "26.1" "18.5" "19.6" "21.2" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3335218336630157461" "False" "High" "IsMasterProtein" "Q9UFN0" "Protein NipSnap homolog 3A OS=Homo sapiens OX=9606 GN=NIPSNAP3A PE=1 SV=2" "0.000" "False" "12.792" "18" "4" "5" "4" "247" "28.4" "9.16" "16.69" "4" "" "cytosol;mitochondrion" "" "Pf07978" "25934" "ENSG00000136783" "NIPSNAP3A" "A6NM55; hsa:25934; Q5VX32; Q9BRV7; Q9H843; Q9P083; Q9UFN0" "" "" "0" "0" "0.948" "1.036" "0.919" "1.032" "1.017" "1.007" "1.023" "1.020" "0.746" "441.2" "418.4" "457.3" "405.4" "455.4" "448.8" "444.4" "451.3" "450.2" "329.0" "" "" "" "" "" "" "" "" "" "" "396.7" "338.5" "413.6" "395.8" "375.8" "448.8" "332.8" "398.6" "402.8" "117.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2663740038882364516" "False" "High" "IsMasterProtein" "Q96S82" "Ubiquitin-like protein 7 OS=Homo sapiens OX=9606 GN=UBL7 PE=1 SV=2" "0.000" "False" "12.784" "11" "3" "4" "3" "380" "40.5" "5.07" "12.32" "3" "protein metabolism;other metabolic processes;stress response" "cytosol;other cell component" "other molecular function" "Pf00240" "84993" "ENSG00000138629; ENSG00000288408" "UBL7" "D3DW57; hsa:84993; Q96I03; Q96S82" "" "" "0" "0" "1.025" "1.015" "0.948" "1.075" "1.023" "1.025" "1.008" "1.032" "1.096" "363.5" "372.7" "369.0" "344.5" "390.6" "371.7" "372.5" "366.5" "375.0" "398.5" "" "" "" "" "" "" "" "" "" "" "326.8" "301.6" "333.8" "336.2" "322.3" "371.7" "278.9" "323.7" "335.5" "142.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2837359330570591993" "False" "High" "IsMasterProtein" "Q15022" "Polycomb protein SUZ12 OS=Homo sapiens OX=9606 GN=SUZ12 PE=1 SV=3" "0.000" "False" "12.768" "5" "4" "4" "3" "739" "83.0" "8.81" "13.84" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf09733" "23512" "ENSG00000178691" "SUZ12" "hsa:23512; Q15022; Q96BD9" "Interactome of polycomb repressive complex 2 (PRC2) ; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma; NF1 copy number variation syndrome" "HCMV Early Events; SUMOylation of chromatin organization proteins; Oxidative Stress Induced Senescence; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PRC2 methylates histones and DNA; Defective pyroptosis; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; PKMTs methylate histone lysines" "15" "0" "1.037" "1.083" "1.047" "1.098" "1.210" "1.086" "0.926" "1.114" "1.827" "404.1" "419.2" "437.5" "423.1" "443.5" "489.1" "438.8" "374.1" "450.0" "738.1" "" "" "" "" "" "" "" "" "" "" "363.3" "339.2" "395.7" "413.0" "366.0" "489.1" "328.6" "330.5" "402.6" "263.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7324571001266765675" "False" "High" "IsMasterProtein" "P29350" "Tyrosine-protein phosphatase non-receptor type 6 OS=Homo sapiens OX=9606 GN=PTPN6 PE=1 SV=1" "0.000" "False" "12.748" "8" "5" "5" "5" "595" "67.5" "7.78" "13.81" "5" "cell adhesion;cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00017, Pf00102" "5777" "ENSG00000111679" "PTPN6" "A8K306; G3V0F8; hsa:5777; P29350; Q969V8; Q9UK67" "Prolactin signaling pathway; B cell receptor signaling pathway; T cell receptor and co-stimulatory signaling; IL-3 signaling pathway; Kit receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; IL-4 signaling pathway; Cancer immunotherapy by CTLA4 blockade; Modulators of TCR signaling and T cell activation; Interferon type I signaling pathways" "Neutrophil degranulation; PD-1 signaling; CD22 mediated BCR regulation; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Signal regulatory protein family interactions; Interleukin receptor SHC signaling; GPVI-mediated activation cascade; Signaling by ALK; Regulation of KIT signaling; Growth hormone receptor signaling; Regulation of IFNG signaling; Regulation of IFNA/IFNB signaling; Interleukin-37 signaling; Platelet sensitization by LDL; PECAM1 interactions; Nuclear events stimulated by ALK signaling in cancer" "33" "0" "1.151" "1.052" "0.954" "1.192" "1.096" "1.033" "1.032" "1.219" "1.432" "380.8" "438.3" "400.5" "363.4" "454.0" "417.4" "393.4" "393.0" "464.3" "545.1" "" "" "" "" "" "" "" "" "" "" "342.4" "354.7" "362.2" "354.8" "374.6" "417.4" "294.6" "347.1" "415.4" "194.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9088787272925242729" "False" "High" "IsMasterProtein" "Q9C0D3" "Protein zyg-11 homolog B OS=Homo sapiens OX=9606 GN=ZYG11B PE=1 SV=2" "0.000" "False" "12.737" "7" "4" "4" "4" "744" "83.9" "6.86" "13.28" "4" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "79699" "ENSG00000162378" "ZYG11B" "hsa:79699; Q8N2X3; Q9C0D3; Q9H8L8" "Ciliary landscape; Hijack of ubiquitination by SARS-CoV-2" "" "2" "0" "0.918" "1.056" "0.915" "1.001" "1.022" "0.878" "0.827" "1.054" "0.937" "194.2" "178.4" "205.1" "177.8" "194.4" "198.5" "170.5" "160.5" "204.8" "182.0" "" "" "" "" "" "" "" "" "" "" "174.6" "144.4" "185.5" "173.5" "160.4" "198.5" "127.7" "141.8" "183.2" "65.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1614464300928510251" "False" "High" "IsMasterProtein" "P55854" "Small ubiquitin-related modifier 3 OS=Homo sapiens OX=9606 GN=SUMO3 PE=1 SV=2" "0.000" "False" "12.735" "26" "3" "9" "1" "103" "11.6" "5.49" "27.65" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11976" "6612" "ENSG00000184900" "SUMO3" "B2R5X4; B4DUW4; hsa:6612; P55854; Q53HI9; Q6FGD4; Q9BWR4" "Exercise-induced circadian regulation" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER; SUMOylation of immune response proteins; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "12" "2" "0.902" "0.818" "0.930" "0.783" "0.846" "0.974" "0.887" "0.760" "0.972" "973.6" "878.5" "796.7" "905.4" "761.9" "823.4" "948.0" "863.4" "739.6" "946.8" "" "" "" "" "" "" "" "" "" "" "875.3" "710.9" "720.6" "883.8" "628.7" "823.4" "709.8" "762.6" "661.8" "338.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1355108408195266018" "False" "High" "IsMasterProtein" "Q6NZ67" "Mitotic-spindle organizing protein 2B OS=Homo sapiens OX=9606 GN=MZT2B PE=1 SV=1" "0.000" "False" "12.701" "44" "4" "6" "2" "158" "16.2" "10.15" "28.39" "4" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "80097" "ENSG00000152082; ENSG00000292119" "MZT2B" "hsa:80097; Q6NZ67; Q96CG4" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "1" "0.947" "1.171" "0.846" "0.890" "1.069" "0.888" "0.864" "0.979" "0.676" "327.3" "310.0" "383.3" "277.1" "291.3" "349.9" "290.7" "282.7" "320.6" "221.2" "" "" "" "" "" "" "" "" "" "" "294.3" "250.9" "346.7" "270.4" "240.4" "349.9" "217.6" "249.7" "286.9" "79.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6678202250508335411" "False" "High" "IsMasterProtein" "Q96CS2" "HAUS augmin-like complex subunit 1 OS=Homo sapiens OX=9606 GN=HAUS1 PE=1 SV=1" "0.000" "False" "12.694" "15" "4" "6" "4" "278" "31.8" "5.53" "20.46" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "" "115106" "ENSG00000152240" "HAUS1" "B2RDM7; hsa:115106; Q8N837; Q96CS2" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.114" "1.195" "1.069" "1.133" "1.213" "1.138" "1.035" "1.298" "3.129" "323.9" "360.8" "387.0" "346.4" "366.9" "393.1" "368.5" "335.2" "420.3" "1013.6" "" "" "" "" "" "" "" "" "" "" "291.3" "292.0" "350.0" "338.1" "302.8" "393.1" "275.9" "296.1" "376.1" "361.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5891546535660205639" "False" "High" "IsMasterProtein" "Q6P1X6" "UPF0598 protein C8orf82 OS=Homo sapiens OX=9606 GN=C8orf82 PE=1 SV=2" "0.000" "False" "12.674" "14" "2" "3" "2" "216" "23.9" "9.14" "13.03" "2" "" "" "" "Pf14956" "414919" "ENSG00000213563" "C8orf82" "hsa:414919; Q6GMR2; Q6P1X6; Q6P2Q7" "" "" "0" "0" "1.302" "1.179" "1.302" "1.256" "1.261" "1.249" "1.404" "1.393" "1.160" "53.5" "69.7" "63.1" "69.7" "67.3" "67.5" "66.9" "75.2" "74.6" "62.1" "" "" "" "" "" "" "" "" "" "" "48.1" "56.4" "57.1" "68.0" "55.5" "67.5" "50.1" "66.4" "66.7" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5295951375825513477" "False" "High" "IsMasterProtein" "Q14186" "Transcription factor Dp-1 OS=Homo sapiens OX=9606 GN=TFDP1 PE=1 SV=1" "0.000" "False" "12.664" "10" "3" "3" "3" "410" "45.0" "6.05" "14.20" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02319, Pf08781" "7027" "ENSG00000198176" "TFDP1" "B4DLQ9; hsa:7027; Q14186; Q5JSB4; Q8IZL5" "Cell cycle; Retinoblastoma gene in cancer; TGF-beta signaling pathway; G1 to S cell cycle control; DYRK1A involvement regarding cell proliferation in brain development" "Oxidative Stress Induced Senescence; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Transcriptional Regulation by E2F6; Pre-NOTCH Transcription and Translation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; Activation of PUMA and translocation to mitochondria; Transcriptional regulation of granulopoiesis; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Activation of NOXA and translocation to mitochondria; Inhibition of replication initiation of damaged DNA by RB1/E2F1; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "23" "0" "1.036" "0.989" "1.063" "1.101" "1.030" "0.969" "0.955" "1.074" "1.251" "384.9" "398.6" "380.7" "409.0" "423.9" "396.3" "372.9" "367.7" "413.3" "481.7" "" "" "" "" "" "" "" "" "" "" "346.0" "322.5" "344.4" "399.3" "349.8" "396.3" "279.2" "324.8" "369.8" "171.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1677605172328813102" "False" "High" "IsMasterProtein" "Q6IAA8" "Ragulator complex protein LAMTOR1 OS=Homo sapiens OX=9606 GN=LAMTOR1 PE=1 SV=2" "0.000" "False" "12.663" "23" "2" "3" "2" "161" "17.7" "5.15" "12.22" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15454" "55004" "ENSG00000149357" "LAMTOR1" "hsa:55004; Q6IAA8; Q8WZ09; Q9NWT0" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "Regulation of PTEN gene transcription; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Neutrophil degranulation; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; CDC42 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; Amino acids regulate mTORC1; RHOJ GTPase cycle; RHOH GTPase cycle" "17" "0" "0.904" "0.991" "1.004" "1.076" "0.804" "0.972" "1.025" "1.046" "1.106" "86.1" "77.8" "85.2" "86.4" "92.6" "69.2" "83.7" "88.2" "90.0" "95.2" "" "" "" "" "" "" "" "" "" "" "77.4" "62.9" "77.1" "84.3" "76.4" "69.2" "62.6" "77.9" "80.5" "34.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7038810457230990351" "False" "High" "IsMasterProtein" "Q8NB15" "Zinc finger protein 511 OS=Homo sapiens OX=9606 GN=ZNF511 PE=1 SV=2" "0.000" "False" "12.656" "20" "4" "5" "4" "252" "28.2" "7.66" "17.61" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "118472" "ENSG00000198546" "ZNF511" "A8K8L5; hsa:118472; Q8NB15; Q8WUP1; Q96BV2" "" "" "0" "0" "1.085" "1.125" "1.023" "1.086" "1.149" "1.128" "1.021" "1.076" "1.126" "377.0" "408.9" "424.2" "385.8" "409.3" "433.0" "425.1" "385.0" "405.8" "424.5" "" "" "" "" "" "" "" "" "" "" "338.9" "330.8" "383.7" "376.6" "337.7" "433.0" "318.3" "340.1" "363.1" "151.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4160171774517724011" "False" "High" "IsMasterProtein" "P51452" "Dual specificity protein phosphatase 3 OS=Homo sapiens OX=9606 GN=DUSP3 PE=1 SV=1" "0.000" "False" "12.651" "23" "3" "3" "3" "185" "20.5" "7.80" "13.82" "3" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00782" "1845" "ENSG00000108861" "DUSP3" "D3DX45; hsa:1845; P51452; Q5U0J1; Q8IYJ9" "MAPK signaling pathway; Fragile X syndrome" "ERKs are inactivated" "3" "0" "1.061" "1.090" "0.988" "1.080" "1.063" "1.168" "1.135" "1.122" "1.039" "155.7" "165.2" "169.7" "153.9" "168.1" "165.5" "181.8" "176.6" "174.6" "161.7" "" "" "" "" "" "" "" "" "" "" "140.0" "133.7" "153.5" "150.2" "138.7" "165.5" "136.1" "156.0" "156.2" "57.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7222165964987125403" "False" "High" "IsMasterProtein" "P36954" "DNA-directed RNA polymerase II subunit RPB9 OS=Homo sapiens OX=9606 GN=POLR2I PE=1 SV=1" "0.000" "False" "12.637" "48" "4" "4" "4" "125" "14.5" "5.14" "7.72" "4" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf02150" "5438" "ENSG00000105258" "POLR2I" "B2R5J2; hsa:5438; P36954; Q6NW05" "Pyrimidine metabolism; Eukaryotic transcription initiation" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "43" "0" "0.925" "0.947" "0.912" "1.015" "0.942" "0.839" "0.988" "1.022" "0.816" "334.0" "309.0" "316.2" "304.8" "339.1" "314.5" "280.3" "329.9" "341.4" "272.5" "" "" "" "" "" "" "" "" "" "" "300.3" "250.0" "286.0" "297.5" "279.8" "314.5" "209.9" "291.4" "305.5" "97.3" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551300482488071361" "False" "High" "IsMasterProtein" "P78332" "RNA-binding protein 6 OS=Homo sapiens OX=9606 GN=RBM6 PE=1 SV=5" "0.000" "False" "12.634" "4" "5" "5" "4" "1123" "128.6" "6.32" "15.44" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf01585, Pf17780" "10180" "ENSG00000004534" "RBM6" "B4E0G6; hsa:10180; O60549; O75524; P78332; Q86SS3" "" "" "0" "0" "1.086" "0.982" "1.056" "1.136" "1.111" "1.214" "1.021" "1.094" "1.622" "239.7" "260.4" "235.5" "253.3" "272.3" "266.3" "291.0" "244.7" "262.2" "388.8" "" "" "" "" "" "" "" "" "" "" "215.5" "210.7" "213.0" "247.2" "224.7" "266.3" "217.9" "216.1" "234.7" "138.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5652857945915371988" "False" "High" "IsMasterProtein" "Q9BQ69" "ADP-ribose glycohydrolase MACROD1 OS=Homo sapiens OX=9606 GN=MACROD1 PE=1 SV=2" "0.000" "False" "12.633" "11" "3" "3" "3" "325" "35.5" "9.51" "13.61" "3" "protein metabolism;other metabolic processes;stress response" "nucleus" "other molecular function" "Pf01661" "28992" "ENSG00000133315" "MACROD1" "hsa:28992; Q9BQ69; Q9UH96" "" "" "0" "0" "1.109" "0.881" "0.829" "0.992" "1.035" "1.255" "0.791" "0.775" "0.747" "53.8" "59.7" "47.4" "44.6" "53.4" "55.7" "67.5" "42.6" "41.7" "40.2" "" "" "" "" "" "" "" "" "" "" "48.4" "48.3" "42.9" "43.6" "44.0" "55.7" "50.6" "37.6" "37.3" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6516926494884828082" "False" "High" "IsMasterProtein" "Q7RTR2" "NLR family CARD domain-containing protein 3 OS=Homo sapiens OX=9606 GN=NLRC3 PE=1 SV=2" "0.000" "False" "12.607" "4" "4" "6" "4" "1065" "114.6" "8.29" "16.24" "4" "signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf05729, Pf13516, Pf17776, Pf17779" "197358" "ENSG00000167984" "NLRC3" "hsa:197358; Q5EY36; Q7RTR2; Q8NF48; Q8NI01; Q8NI02; Q8TEL3" "" "IRF3-mediated induction of type I IFN" "1" "0" "0.966" "0.995" "0.853" "0.972" "0.876" "0.882" "0.915" "0.945" "0.792" "750.3" "725.0" "746.3" "640.0" "729.5" "657.0" "661.8" "686.7" "709.2" "594.0" "" "" "" "" "" "" "" "" "" "" "674.6" "586.6" "675.0" "624.7" "602.0" "657.0" "495.5" "606.6" "634.5" "212.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256301948778102802" "False" "High" "IsMasterProtein" "Q8NCE0" "tRNA-splicing endonuclease subunit Sen2 OS=Homo sapiens OX=9606 GN=TSEN2 PE=1 SV=2" "0.000" "False" "12.602" "9" "5" "5" "5" "465" "53.2" "7.85" "15.64" "5" "RNA metabolism OR transcription;other metabolic processes" "cytosol;cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf01974, Pf02778" "80746" "ENSG00000154743" "TSEN2" "B7Z6K1; C9IZI7; G5E9Q3; hsa:80746; Q8NCE0; Q8WTW7; Q9BPU7" "" "tRNA processing in the nucleus" "1" "0" "1.004" "0.989" "0.972" "1.004" "1.073" "0.946" "0.980" "1.013" "1.067" "386.0" "387.5" "381.6" "375.3" "387.5" "414.2" "365.0" "378.4" "390.9" "411.9" "" "" "" "" "" "" "" "" "" "" "347.0" "313.5" "345.2" "366.4" "319.8" "414.2" "273.3" "334.2" "349.8" "147.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "549572925276105069" "False" "High" "IsMasterProtein" "P11274" "Breakpoint cluster region protein OS=Homo sapiens OX=9606 GN=BCR PE=1 SV=2" "0.000" "False" "12.596" "4" "5" "7" "3" "1271" "142.7" "7.03" "18.63" "5" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00168, Pf00620, Pf00621, Pf09036, Pf19057" "613" "ENSG00000186716" "BCR" "hsa:613; P11274; P78501; Q12842; Q4LE80; Q6NZI3" "Imatinib and chronic myeloid leukemia; Extrafollicular and follicular B cell activation by SARS-CoV-2" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "11" "0" "0.943" "0.868" "0.849" "0.889" "0.820" "0.880" "0.725" "0.836" "1.233" "123.7" "116.7" "107.3" "105.0" "109.9" "101.4" "108.9" "89.7" "103.4" "152.5" "" "" "" "" "" "" "" "" "" "" "111.2" "94.4" "97.1" "102.5" "90.7" "101.4" "81.6" "79.2" "92.5" "54.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2803114814399122734" "False" "High" "IsMasterProtein" "Q8NFI3" "Cytosolic endo-beta-N-acetylglucosaminidase OS=Homo sapiens OX=9606 GN=ENGASE PE=1 SV=1" "0.000" "False" "12.585" "6" "4" "4" "4" "743" "83.9" "6.79" "13.64" "4" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf03644" "64772" "ENSG00000167280" "ENGASE" "hsa:64772; Q659F0; Q8NFI3; Q8TB86; Q9H6U4" "" "N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "1" "0" "1.018" "0.966" "0.925" "1.031" "1.021" "0.965" "1.008" "0.940" "0.840" "366.6" "373.1" "354.2" "339.0" "377.8" "374.3" "353.9" "369.5" "344.6" "307.9" "" "" "" "" "" "" "" "" "" "" "329.6" "301.9" "320.4" "330.9" "311.8" "374.3" "265.0" "326.4" "308.4" "109.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4573891914704923062" "False" "High" "IsMasterProtein" "Q9BTE1" "Dynactin subunit 5 OS=Homo sapiens OX=9606 GN=DCTN5 PE=1 SV=1" "0.000" "False" "12.583" "16" "3" "4" "3" "182" "20.1" "8.02" "15.90" "3" "developmental processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "" "Pf21711" "84516" "ENSG00000166847" "DCTN5" "A8K9X8; H3BN51; H3BQA4; hsa:84516; Q9BTE1" "Vasopressin-regulated water reabsorption" "COPI-mediated anterograde transport; MHC class II antigen presentation; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; COPI-independent Golgi-to-ER retrograde traffic" "5" "0" "1.128" "1.154" "1.056" "1.190" "1.116" "0.991" "1.066" "1.218" "0.945" "528.8" "596.5" "610.3" "558.2" "629.2" "589.9" "524.2" "563.6" "644.1" "499.9" "" "" "" "" "" "" "" "" "" "" "475.4" "482.7" "552.0" "544.9" "519.3" "589.9" "392.5" "497.9" "576.4" "178.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5866289401045489846" "False" "High" "IsMasterProtein" "Q92616" "Stalled ribosome sensor GCN1 OS=Homo sapiens OX=9606 GN=GCN1 PE=1 SV=7" "0.000" "False" "12.574" "2" "5" "5" "5" "2671" "292.5" "7.43" "12.43" "5" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;translation activity;nucleic acid binding activity;other molecular function" "" "10985" "ENSG00000089154" "GCN1" "A8KAY1; hsa:10985; O95001; O95651; Q6P2S3; Q86X65; Q8N5I5; Q8WU80; Q92616; Q99736; Q9UE60" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "1.041" "1.049" "0.965" "0.955" "0.922" "1.235" "0.887" "1.020" "4.321" "93.3" "97.1" "97.8" "90.0" "89.1" "85.9" "115.2" "82.7" "95.1" "402.9" "" "" "" "" "" "" "" "" "" "" "83.8" "78.6" "88.5" "87.8" "73.5" "85.9" "86.2" "73.1" "85.1" "143.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037258603534985886" "False" "High" "IsMasterProtein" "Q12974" "Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens OX=9606 GN=PTP4A2 PE=1 SV=1" "0.000" "False" "12.565" "28" "4" "5" "4" "167" "19.1" "8.37" "15.99" "4" "other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00102" "8073" "ENSG00000184007" "PTP4A2" "A8K9I8; B4DM39; D3DPP0; E9PGJ6; hsa:8073; O00649; Q12974; Q15197; Q15259; Q15260; Q15261; R4GN50" "" "RAB geranylgeranylation" "1" "0" "0.918" "0.910" "0.966" "0.961" "0.894" "0.952" "0.952" "0.978" "0.770" "417.8" "383.7" "380.1" "403.8" "401.4" "373.6" "397.9" "397.6" "408.8" "321.8" "" "" "" "" "" "" "" "" "" "" "375.6" "310.5" "343.8" "394.1" "331.2" "373.6" "297.9" "351.2" "365.8" "114.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2272121550069660062" "False" "High" "IsMasterProtein" "P35268" "Large ribosomal subunit protein eL22 OS=Homo sapiens OX=9606 GN=RPL22 PE=1 SV=2" "0.000" "False" "12.563" "22" "2" "3" "2" "128" "14.8" "9.19" "12.59" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01776" "6146" "ENSG00000116251" "RPL22" "B2R495; hsa:6146; P35268; Q6IBD1" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.958" "0.931" "0.881" "1.030" "1.088" "0.981" "1.000" "1.014" "0.967" "171.8" "164.6" "159.9" "151.4" "176.9" "186.8" "168.6" "171.7" "174.1" "166.1" "" "" "" "" "" "" "" "" "" "" "154.5" "133.2" "144.6" "147.7" "146.0" "186.8" "126.2" "151.7" "155.8" "59.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2009028340265945261" "False" "High" "IsMasterProtein" "Q5QJE6" "Deoxynucleotidyltransferase terminal-interacting protein 2 OS=Homo sapiens OX=9606 GN=DNTTIP2 PE=1 SV=2" "0.000" "False" "12.554" "6" "5" "5" "5" "756" "84.4" "6.16" "13.60" "5" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf08698" "30836" "ENSG00000067334" "DNTTIP2" "hsa:30836; Q12987; Q53H59; Q5QJE6; Q5TFJ4; Q6TLI0; Q76MJ8; Q86WX9" "" "" "0" "0" "0.994" "0.794" "1.020" "1.013" "0.912" "1.060" "1.091" "0.864" "0.689" "164.9" "163.9" "131.0" "168.1" "167.0" "150.4" "174.8" "180.0" "142.6" "113.6" "" "" "" "" "" "" "" "" "" "" "148.3" "132.6" "118.5" "164.1" "137.8" "150.4" "130.9" "159.0" "127.6" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7917759671781486439" "False" "High" "IsMasterProtein" "Q13627" "Dual specificity tyrosine-phosphorylation-regulated kinase 1A OS=Homo sapiens OX=9606 GN=DYRK1A PE=1 SV=2" "0.000" "False" "12.546" "5" "4" "4" "4" "763" "85.5" "8.75" "13.38" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069" "1859" "ENSG00000157540" "DYRK1A" "hsa:1859; O60769; Q13627; Q92582; Q92810; Q9UNM5" "T cell receptor and co-stimulatory signaling; DYRK1A involvement regarding cell proliferation in brain development" "G0 and Early G1" "3" "0" "1.011" "0.945" "0.828" "1.002" "0.923" "1.111" "0.960" "0.818" "1.005" "163.4" "165.2" "154.4" "135.3" "163.7" "150.9" "181.6" "156.9" "133.6" "164.2" "" "" "" "" "" "" "" "" "" "" "146.9" "133.7" "139.7" "132.1" "135.1" "150.9" "136.0" "138.6" "119.6" "58.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1811232654349558643" "False" "High" "IsMasterProtein" "P18846" "Cyclic AMP-dependent transcription factor ATF-1 OS=Homo sapiens OX=9606 GN=ATF1 PE=1 SV=2" "0.000" "False" "12.529" "11" "4" "8" "2" "271" "29.2" "8.37" "21.75" "4" "cell organization and biogenesis;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf02173" "466" "ENSG00000123268" "ATF1" "B4DRF9; hsa:466; P18846; P25168; Q9H4A8" "Integrated cancer pathway; Androgen receptor network in prostate cancer; Interleukin-11 signaling pathway; Myometrial relaxation and contraction pathways; EGF/EGFR signaling pathway; GDNF signaling; Serotonin receptor 4/6/7 and NR3C signaling" "NGF-stimulated transcription; CREB phosphorylation" "9" "0" "1.002" "1.020" "0.977" "1.061" "0.971" "1.116" "1.123" "0.929" "0.839" "410.8" "411.6" "419.0" "401.1" "435.9" "398.8" "458.6" "461.2" "381.6" "344.6" "" "" "" "" "" "" "" "" "" "" "369.3" "333.1" "379.0" "391.6" "359.7" "398.8" "343.4" "407.3" "341.5" "123.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5638474282161267402" "False" "High" "IsMasterProtein" "Q969Z0" "FAST kinase domain-containing protein 4 OS=Homo sapiens OX=9606 GN=TBRG4 PE=1 SV=1" "0.000" "False" "12.525" "6" "4" "4" "4" "631" "70.7" "7.42" "13.60" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "" "Pf06743, Pf08368, Pf08373" "9238" "ENSG00000136270" "TBRG4" "A4D2L2; A4D2L3; D3DVL5; D3DVL6; hsa:9238; O14710; Q53GI8; Q8NDM4; Q969Z0; Q9BUC6; Q9Y2F6" "" "FASTK family proteins regulate processing and stability of mitochondrial RNAs" "1" "0" "1.015" "0.908" "0.962" "1.050" "0.898" "1.030" "1.037" "0.926" "3.413" "150.3" "152.6" "136.5" "144.6" "157.8" "135.0" "154.8" "155.9" "139.2" "513.1" "" "" "" "" "" "" "" "" "" "" "135.1" "123.4" "123.5" "141.2" "130.2" "135.0" "115.9" "137.7" "124.6" "183.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1713406968265840354" "False" "High" "IsMasterProtein" "O60825" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Homo sapiens OX=9606 GN=PFKFB2 PE=1 SV=2" "0.000" "False" "12.507" "8" "5" "5" "4" "505" "58.4" "8.38" "15.40" "5" "other metabolic processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf00300, Pf01591" "5208" "ENSG00000123836" "PFKFB2" "hsa:5208; O60824; O60825; Q5VVQ3; Q5VVQ4; Q9H3P1" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Thyroid hormones production and peripheral downstream signaling effects" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "0.990" "1.108" "0.997" "1.135" "0.961" "0.985" "1.009" "1.022" "0.891" "296.8" "293.8" "328.8" "295.9" "336.8" "285.1" "292.3" "299.4" "303.2" "264.6" "" "" "" "" "" "" "" "" "" "" "266.8" "237.7" "297.4" "288.8" "277.9" "285.1" "218.8" "264.4" "271.3" "94.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-572232975925861742" "False" "High" "IsMasterProtein" "P46779" "Large ribosomal subunit protein eL28 OS=Homo sapiens OX=9606 GN=RPL28 PE=1 SV=3" "0.000" "False" "12.501" "27" "4" "4" "4" "137" "15.7" "12.02" "12.37" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01778" "6158" "ENSG00000108107" "RPL28" "B2R4A6; B4DEP9; C9JB50; E9PB24; G5E9L2; hsa:6158; P46779; Q6IAY0; Q96FX1; Q9BWQ0" "Cytoplasmic ribosomal proteins" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.122" "1.066" "1.079" "1.120" "1.052" "1.049" "1.132" "1.198" "0.796" "557.5" "625.3" "594.4" "601.4" "624.3" "586.5" "584.9" "631.3" "667.8" "443.9" "" "" "" "" "" "" "" "" "" "" "501.2" "505.9" "537.6" "587.1" "515.2" "586.5" "437.9" "557.6" "597.5" "158.4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5511043592146931857" "False" "High" "IsMasterProtein" "Q9BSB4" "Autophagy-related protein 101 OS=Homo sapiens OX=9606 GN=ATG101 PE=1 SV=1" "0.000" "False" "12.497" "17" "4" "4" "4" "218" "25.0" "6.15" "13.26" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07855" "60673" "ENSG00000123395" "ATG101" "hsa:60673; Q9BSB4; Q9HAE2; Q9HBN1" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism; 8q11.23 (RB1CC1) copy number variation; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "8" "0" "0.960" "0.932" "0.978" "1.027" "0.926" "1.062" "1.023" "0.990" "1.105" "231.4" "222.3" "215.7" "226.3" "237.6" "214.3" "245.7" "236.8" "229.1" "255.7" "" "" "" "" "" "" "" "" "" "" "208.1" "179.9" "195.1" "220.9" "196.1" "214.3" "184.0" "209.2" "205.0" "91.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2806673757180566722" "False" "High" "IsMasterProtein" "P54709" "Sodium/potassium-transporting ATPase subunit beta-3 OS=Homo sapiens OX=9606 GN=ATP1B3 PE=1 SV=1" "0.000" "False" "12.492" "13" "3" "4" "3" "279" "31.5" "8.35" "13.65" "3" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00287" "483" "ENSG00000069849" "ATP1B3" "B7Z1N7; hsa:483; P54709" "Calcium regulation in cardiac cells" "Potential therapeutics for SARS; Ion homeostasis; Ion transport by P-type ATPases; Basigin interactions" "5" "0" "0.932" "0.881" "1.075" "0.857" "0.802" "0.903" "0.858" "0.998" "0.766" "139.4" "130.0" "122.8" "149.9" "119.6" "111.9" "125.9" "119.7" "139.2" "106.8" "" "" "" "" "" "" "" "" "" "" "125.4" "105.2" "111.1" "146.3" "98.7" "111.9" "94.3" "105.7" "124.6" "38.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5130532040742567239" "False" "High" "IsMasterProtein" "Q9HCN8" "Stromal cell-derived factor 2-like protein 1 OS=Homo sapiens OX=9606 GN=SDF2L1 PE=1 SV=2" "0.000" "False" "12.483" "13" "3" "5" "3" "221" "23.6" "7.03" "15.22" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf02815" "23753" "ENSG00000128228" "SDF2L1" "A2RUD3; hsa:23753; Q9BRI5; Q9HCN8" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.008" "1.078" "1.031" "1.053" "1.112" "1.062" "1.071" "1.142" "0.963" "465.2" "468.8" "501.4" "479.7" "489.7" "517.2" "494.2" "498.3" "531.1" "447.9" "" "" "" "" "" "" "" "" "" "" "418.3" "379.3" "453.5" "468.2" "404.1" "517.2" "370.0" "440.1" "475.3" "159.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6883874888390724890" "False" "High" "IsMasterProtein" "Q5VTL8" "Pre-mRNA-splicing factor 38B OS=Homo sapiens OX=9606 GN=PRPF38B PE=1 SV=1" "0.000" "False" "12.478" "9" "5" "6" "5" "546" "64.4" "10.54" "13.50" "5" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371" "55119" "ENSG00000134186" "PRPF38B" "hsa:55119; Q05DD6; Q32Q58; Q5VTL8; Q5VTL9; Q6PK39; Q7Z6E2; Q86WF3; Q8IWG9; Q9NW40" "" "" "0" "0" "0.925" "0.948" "0.836" "0.884" "1.138" "0.932" "1.011" "0.919" "0.647" "204.3" "189.0" "193.7" "170.8" "180.7" "232.6" "190.4" "206.5" "187.9" "132.2" "" "" "" "" "" "" "" "" "" "" "183.7" "152.9" "175.2" "166.7" "149.1" "232.6" "142.6" "182.4" "168.1" "47.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9076326979726242055" "False" "High" "IsMasterProtein" "Q9P2K6" "Kelch-like protein 42 OS=Homo sapiens OX=9606 GN=KLHL42 PE=1 SV=2" "0.000" "False" "12.461" "6" "2" "4" "2" "505" "56.8" "5.74" "13.79" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf01344, Pf07707" "57542" "ENSG00000087448" "KLHL42" "hsa:57542; Q2VPK1; Q8N334; Q9P2K6" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.229" "1.080" "1.135" "1.027" "1.159" "1.245" "0.987" "1.046" "1.365" "60.6" "74.5" "65.5" "68.8" "62.2" "70.3" "75.5" "59.8" "63.4" "82.7" "" "" "" "" "" "" "" "" "" "" "54.5" "60.3" "59.2" "67.2" "51.4" "70.3" "56.5" "52.8" "56.7" "29.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1893119365438926918" "False" "High" "IsMasterProtein" "Q86UU0" "B-cell CLL/lymphoma 9-like protein OS=Homo sapiens OX=9606 GN=BCL9L PE=1 SV=1" "0.000" "False" "12.429" "2" "4" "4" "4" "1499" "157.0" "8.63" "14.61" "4" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf11502" "283149" "ENSG00000186174" "BCL9L" "A1A4C1; hsa:283149; Q67FY1; Q6ZWJ0; Q6ZWK2; Q86UU0" "" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "2" "0" "0.971" "0.988" "0.990" "0.988" "1.001" "0.975" "1.010" "1.020" "1.151" "522.6" "507.5" "516.1" "517.4" "516.3" "523.3" "509.7" "527.7" "533.0" "601.5" "" "" "" "" "" "" "" "" "" "" "469.9" "410.7" "466.9" "505.0" "426.1" "523.3" "381.7" "466.1" "476.9" "214.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2591568921065242388" "False" "High" "IsMasterProtein" "Q8NB90" "ATPase family gene 2 protein homolog A OS=Homo sapiens OX=9606 GN=AFG2A PE=1 SV=3" "0.000" "False" "12.425" "3" "2" "8" "1" "893" "97.8" "5.66" "27.05" "2" "developmental processes;other biological processes" "cytoskeleton;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf17862" "166378" "ENSG00000145375" "AFG2A" "C9JT97; hsa:166378; Q86XW1; Q8NB90; Q8NI20; Q8TDL7" "" "" "0" "0" "0.930" "0.878" "0.887" "1.163" "1.018" "0.982" "0.926" "0.806" "0.595" "85.8" "79.9" "75.4" "76.1" "99.8" "87.4" "84.3" "79.5" "69.2" "51.0" "" "" "" "" "" "" "" "" "" "" "77.2" "64.6" "68.2" "74.3" "82.4" "87.4" "63.1" "70.2" "61.9" "18.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1339372435308816495" "False" "High" "IsMasterProtein" "Q8IWT0" "Protein archease OS=Homo sapiens OX=9606 GN=ZBTB8OS PE=1 SV=2" "0.000" "False" "12.424" "23" "4" "4" "4" "167" "19.5" "4.49" "14.55" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01951" "339487" "ENSG00000176261" "ZBTB8OS" "hsa:339487; Q5TGK5; Q6PDA1; Q8IWS9; Q8IWT0; Q8NEV6; Q8NEV7" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5049271637643204736" "False" "High" "IsMasterProtein" "Q96F63" "Coiled-coil domain-containing protein 97 OS=Homo sapiens OX=9606 GN=CCDC97 PE=1 SV=1" "0.000" "False" "12.409" "13" "3" "3" "3" "343" "38.9" "4.59" "13.08" "3" "" "nucleus" "" "Pf09747" "90324" "ENSG00000142039" "CCDC97" "hsa:90324; Q658N6; Q96F63; Q96IF3" "" "" "0" "0" "1.059" "1.018" "0.849" "1.311" "1.210" "1.175" "0.992" "1.177" "1.433" "207.5" "219.7" "211.3" "176.1" "272.0" "251.1" "243.9" "205.9" "244.3" "297.4" "" "" "" "" "" "" "" "" "" "" "186.6" "177.7" "191.1" "171.9" "224.4" "251.1" "182.6" "181.9" "218.6" "106.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4751466246164002184" "False" "High" "IsMasterProtein" "O60613" "Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4" "0.000" "False" "12.403" "15" "2" "3" "2" "165" "18.1" "5.03" "11.66" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "ER/Golgi" "other molecular function" "Pf08806" "9403" "ENSG00000183291" "SELENOF" "A0A0B4J1S4; hsa:9403; O60613; Q4GZG7; Q8WU00; Q9BS64; Q9GZW0; Q9NR01" "Selenium metabolism / selenoproteins; Selenium micronutrient network" "" "2" "0" "0.937" "0.845" "0.820" "1.165" "0.833" "0.753" "1.054" "0.880" "0.840" "37.7" "35.3" "31.9" "30.9" "43.9" "31.4" "28.4" "39.7" "33.2" "31.7" "" "" "" "" "" "" "" "" "" "" "33.9" "28.6" "28.8" "30.2" "36.3" "31.4" "21.3" "35.1" "29.7" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3798154804985713391" "False" "High" "IsMasterProtein" "P41229" "Lysine-specific demethylase 5C OS=Homo sapiens OX=9606 GN=KDM5C PE=1 SV=2" "0.000" "False" "12.391" "3" "4" "5" "4" "1560" "175.6" "5.58" "12.64" "4" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00628, Pf01388, Pf02373, Pf02375, Pf02928, Pf08429, Pf21323" "8242" "ENSG00000126012" "KDM5C" "B0QZ44; B4E3I2; F5H3T1; hsa:8242; P41229; Q5JUX3; Q5JUX4; Q5JUX5; Q7Z5S5" "Clear cell renal cell carcinoma pathways" "HDMs demethylate histones" "2" "0" "1.132" "1.016" "0.950" "1.227" "1.107" "1.173" "1.084" "1.068" "1.215" "245.7" "278.2" "249.5" "233.3" "301.6" "272.1" "288.1" "266.3" "262.3" "298.6" "" "" "" "" "" "" "" "" "" "" "220.9" "225.1" "225.7" "227.7" "248.9" "272.1" "215.7" "235.2" "234.7" "106.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308082143838358470" "False" "High" "IsMasterProtein" "P42766" "Large ribosomal subunit protein uL29 OS=Homo sapiens OX=9606 GN=RPL35 PE=1 SV=2" "0.000" "False" "12.374" "24" "4" "6" "4" "123" "14.5" "11.05" "20.77" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00831" "11224" "ENSG00000136942" "RPL35" "A8K4V7; hsa:11224; P42766; Q4VBY5; Q5JTN5; Q6IBC7; Q96QJ7; Q9BYF4" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.131" "0.967" "1.084" "1.116" "1.078" "1.056" "1.191" "1.181" "1.044" "815.6" "922.1" "789.1" "883.9" "910.1" "879.0" "861.7" "971.7" "962.9" "851.1" "" "" "" "" "" "" "" "" "" "" "733.3" "746.1" "713.7" "862.8" "751.0" "879.0" "645.2" "858.3" "861.6" "303.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5107037615117632570" "False" "High" "IsMasterProtein" "P07992" "DNA excision repair protein ERCC-1 OS=Homo sapiens OX=9606 GN=ERCC1 PE=1 SV=1" "0.000" "False" "12.347" "15" "4" "4" "4" "297" "32.5" "6.25" "13.80" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00633, Pf03834" "2067" "ENSG00000012061" "ERCC1" "B2RC01; B3KRR0; hsa:2067; P07992; Q7Z7F5; Q96S40" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Fanconi Anemia Pathway; Dual incision in TC-NER; HDR through Single Strand Annealing (SSA); Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "9" "0" "1.072" "1.006" "0.981" "0.951" "1.068" "1.051" "1.058" "1.025" "1.489" "147.2" "157.7" "148.1" "144.4" "140.0" "157.2" "154.7" "155.8" "150.9" "219.2" "" "" "" "" "" "" "" "" "" "" "132.3" "127.6" "133.9" "141.0" "115.5" "157.2" "115.9" "137.6" "135.0" "78.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7420075580370482485" "False" "High" "IsMasterProtein" "P14209" "CD99 antigen OS=Homo sapiens OX=9606 GN=CD99 PE=1 SV=1" "0.000" "False" "12.345" "13" "2" "6" "2" "185" "18.8" "4.75" "20.48" "2" "cell adhesion;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf12301" "4267" "ENSG00000002586; ENSG00000292348" "CD99" "A6NIW1; hsa:4267; O00518; P14209; Q6ICV7" "" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall" "2" "0" "0.913" "1.027" "0.830" "0.925" "0.886" "0.789" "0.946" "0.919" "0.791" "165.5" "151.1" "170.0" "137.4" "153.0" "146.7" "130.5" "156.6" "152.1" "131.0" "" "" "" "" "" "" "" "" "" "" "148.8" "122.3" "153.8" "134.1" "126.3" "146.7" "97.7" "138.3" "136.1" "46.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9000189900637042825" "False" "High" "IsMasterProtein" "Q6JQN1" "Acyl-CoA dehydrogenase family member 10 OS=Homo sapiens OX=9606 GN=ACAD10 PE=1 SV=1" "0.000" "False" "12.344" "5" "5" "5" "5" "1059" "118.8" "8.06" "13.50" "5" "other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf00441, Pf00702, Pf01636, Pf02770, Pf02771" "80724" "ENSG00000111271" "ACAD10" "G3XAJ0; hsa:80724; Q6JQN1; Q8N828; Q8NAP2; Q96BX5" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.922" "0.830" "0.994" "1.045" "0.813" "0.890" "0.879" "0.867" "1.189" "131.6" "121.4" "109.2" "130.8" "137.6" "106.9" "117.1" "115.7" "114.1" "156.4" "" "" "" "" "" "" "" "" "" "" "118.3" "98.2" "98.8" "127.7" "113.5" "106.9" "87.7" "102.2" "102.1" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4805951626840685734" "False" "High" "IsMasterProtein" "P50336" "Protoporphyrinogen oxidase OS=Homo sapiens OX=9606 GN=PPOX PE=1 SV=1" "0.000" "False" "12.338" "9" "4" "4" "4" "477" "50.7" "8.16" "14.66" "4" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf01593" "5498" "ENSG00000143224" "PPOX" "D3DVG0; hsa:5498; P50336; Q5VTW8" "Orexin receptor pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "Heme biosynthesis" "4" "0" "1.075" "1.054" "1.170" "1.027" "1.150" "1.145" "1.055" "1.140" "1.137" "203.0" "218.2" "213.9" "237.5" "208.4" "233.5" "232.5" "214.2" "231.3" "230.7" "" "" "" "" "" "" "" "" "" "" "182.5" "176.6" "193.5" "231.8" "172.0" "233.5" "174.1" "189.2" "207.0" "82.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-90342498941342912" "False" "High" "IsMasterProtein" "Q8N8R5" "Mitochondrial protein C2orf69 OS=Homo sapiens OX=9606 GN=C2orf69 PE=1 SV=1" "0.000" "False" "12.320" "7" "2" "4" "2" "385" "43.4" "8.09" "13.11" "2" "other metabolic processes" "other membranes;mitochondrion" "" "Pf10561" "205327" "ENSG00000178074" "C2orf69" "hsa:205327; Q8N8R5; Q8NE30" "" "" "0" "0" "1.046" "0.933" "0.905" "1.018" "1.002" "1.212" "1.029" "1.011" "0.822" "126.5" "132.3" "118.1" "114.5" "128.9" "126.7" "153.3" "130.2" "127.9" "104.0" "" "" "" "" "" "" "" "" "" "" "113.8" "107.1" "106.8" "111.8" "106.3" "126.7" "114.8" "115.0" "114.4" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-700049213662343528" "False" "High" "IsMasterProtein" "P06396" "Gelsolin OS=Homo sapiens OX=9606 GN=GSN PE=1 SV=1" "0.000" "False" "12.316" "7" "3" "3" "3" "782" "85.6" "6.28" "13.29" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00626" "2934" "ENSG00000148180" "GSN" "A2A418; A8MUD1; A8MYN7; B7Z373; B7Z5V1; F5H1A8; hsa:2934; P06396; Q5T0I2; Q8WVV7" "Ebola virus infection in host; Regulation of actin cytoskeleton" "Amyloid fiber formation; Sensory processing of sound by outer hair cells of the cochlea; Neutrophil degranulation; Caspase-mediated cleavage of cytoskeletal proteins" "6" "0" "0.875" "1.017" "1.016" "0.896" "1.002" "0.913" "0.941" "1.084" "0.864" "170.9" "149.6" "173.8" "173.7" "153.2" "171.2" "156.1" "160.9" "185.2" "147.7" "" "" "" "" "" "" "" "" "" "" "153.7" "121.1" "157.2" "169.5" "126.4" "171.2" "116.9" "142.1" "165.7" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-319216844392798796" "False" "High" "IsMasterProtein" "Q9Y4R8" "Telomere length regulation protein TEL2 homolog OS=Homo sapiens OX=9606 GN=TELO2 PE=1 SV=2" "0.000" "False" "12.298" "6" "5" "5" "5" "837" "91.7" "5.76" "11.77" "5" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10193" "9894" "ENSG00000100726" "TELO2" "D3DU73; hsa:9894; O75168; Q7LDV4; Q9BR21; Q9Y4R8" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "0.887" "1.017" "0.801" "0.905" "0.779" "0.856" "0.863" "0.765" "1.374" "614.2" "544.6" "624.9" "491.7" "555.9" "478.7" "525.9" "530.3" "469.8" "844.2" "" "" "" "" "" "" "" "" "" "" "552.2" "440.7" "565.2" "480.0" "458.7" "478.7" "393.8" "468.4" "420.4" "301.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "676002530395001225" "False" "High" "IsMasterProtein" "Q14766" "Latent-transforming growth factor beta-binding protein 1 OS=Homo sapiens OX=9606 GN=LTBP1 PE=1 SV=4" "0.000" "False" "12.286" "3" "3" "3" "3" "1721" "186.7" "5.96" "10.22" "3" "signal transduction;other biological processes" "extracellular matrix;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00683, Pf07645, Pf12662" "4052" "ENSG00000049323" "LTBP1" "A1L3V1; hsa:4052; P22064; Q14766; Q53SD8; Q53SF3; Q53SG1; Q59HF7; Q8TD95" "Hypothesized pathways in pathogenesis of cardiovascular disease; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Molecules associated with elastic fibres; TGF-beta receptor signaling activates SMADs" "7" "0" "1.146" "1.015" "1.021" "1.122" "0.845" "1.252" "1.248" "0.921" "0.677" "62.4" "71.5" "63.3" "63.7" "70.0" "52.7" "78.1" "77.8" "57.5" "42.2" "" "" "" "" "" "" "" "" "" "" "56.1" "57.8" "57.2" "62.2" "57.7" "52.7" "58.4" "68.7" "51.4" "15.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-241917759717494375" "False" "High" "IsMasterProtein" "Q76I76" "Protein phosphatase Slingshot homolog 2 OS=Homo sapiens OX=9606 GN=SSH2 PE=1 SV=1" "0.000" "False" "12.282" "3" "4" "4" "4" "1423" "158.1" "5.41" "13.72" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00782, Pf08766" "85464" "ENSG00000141298" "SSH2" "hsa:85464; Q76I76; Q8TDB5; Q8WYL1; Q8WYL2; Q96F40; Q96H36; Q9C0D8" "Regulation of actin cytoskeleton" "" "1" "0" "1.010" "1.083" "0.988" "1.038" "0.958" "0.974" "0.979" "1.053" "0.971" "460.0" "464.7" "498.0" "454.4" "477.6" "440.7" "448.1" "450.1" "484.3" "446.6" "" "" "" "" "" "" "" "" "" "" "413.6" "376.0" "450.5" "443.6" "394.1" "440.7" "335.5" "397.6" "433.4" "159.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5021864284547303722" "False" "High" "IsMasterProtein" "Q96GD4" "Aurora kinase B OS=Homo sapiens OX=9606 GN=AURKB PE=1 SV=3" "0.000" "False" "12.261" "12" "4" "4" "3" "344" "39.3" "9.29" "12.70" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9212" "ENSG00000178999" "AURKB" "B4DNM4; C7G533; C7G534; C7G535; D3DTR4; hsa:9212; J9JID1; O14630; O60446; O95083; Q96DV5; Q96GD4; Q9UQ46" "Microtubule cytoskeleton regulation; ATM signaling in development and disease" "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Separation of Sister Chromatids; Regulation of TP53 Activity through Phosphorylation; Regulation of MECP2 expression and activity; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "12" "0" "1.131" "1.188" "1.069" "0.904" "1.219" "1.123" "1.071" "1.061" "1.550" "69.5" "78.6" "82.6" "74.3" "62.8" "84.7" "78.1" "74.4" "73.7" "107.7" "" "" "" "" "" "" "" "" "" "" "62.5" "63.6" "74.7" "72.5" "51.9" "84.7" "58.4" "65.7" "66.0" "38.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824590419555307181" "False" "High" "IsMasterProtein" "P63165" "Small ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=SUMO1 PE=1 SV=1" "0.000" "False" "12.260" "43" "5" "7" "5" "101" "11.6" "5.52" "21.66" "5" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "other molecular function" "Pf11976" "7341" "ENSG00000116030" "SUMO1" "A8MUS8; B2R4I5; hsa:7341; P55856; P63165; Q6FGG0; Q6NZ62; Q93068" "Androgen receptor signaling pathway; TP53 network; TGF-beta signaling pathway; Exercise-induced circadian regulation" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Regulation of IFNG signaling; SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; PKR-mediated signaling; SUMOylation of ubiquitinylation proteins; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; SUMOylation of intracellular receptors; SUMOylation of transcription factors; Postmitotic nuclear pore complex (NPC) reformation; Negative regulation of activity of TFAP2 (AP-2) family transcription factors; Maturation of nucleoprotein; SUMOylation of immune response proteins; SUMOylation of nuclear envelope proteins; Maturation of nucleoprotein; SUMO is conjugated to E1 (UBA2:SAE1); SUMO is transferred from E1 to E2 (UBE2I, UBC9); SUMO is proteolytically processed" "27" "0" "0.922" "0.870" "1.042" "0.929" "0.897" "1.024" "0.882" "0.841" "1.186" "1198.0" "1104.5" "1041.9" "1248.1" "1113.1" "1074.1" "1226.6" "1056.6" "1007.6" "1420.8" "" "" "" "" "" "" "" "" "" "" "1077.1" "893.7" "942.5" "1218.3" "918.6" "1074.1" "918.4" "933.3" "901.6" "507.2" "5" "5" "5" "5" "5" "5" "5" "5" "5" "5" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "418728153778102369" "False" "High" "IsMasterProtein" "Q13029" "PR domain zinc finger protein 2 OS=Homo sapiens OX=9606 GN=PRDM2 PE=1 SV=3" "0.000" "False" "12.231" "2" "2" "3" "2" "1718" "188.8" "7.31" "11.64" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912, Pf21549" "7799" "ENSG00000116731" "PRDM2" "B1AJZ4; B5MC68; hsa:7799; Q13029; Q13149; Q14550; Q5THJ1; Q5VUL9" "Histone modifications" "" "1" "0" "1.018" "1.014" "0.978" "0.992" "1.022" "0.996" "0.970" "0.967" "0.870" "312.0" "317.6" "316.4" "305.1" "309.6" "318.9" "310.8" "302.5" "301.6" "271.4" "" "" "" "" "" "" "" "" "" "" "280.5" "257.0" "286.2" "297.8" "255.5" "318.9" "232.7" "267.2" "269.8" "96.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2492705213444431370" "False" "High" "IsMasterProtein" "Q8TE04" "Pantothenate kinase 1 OS=Homo sapiens OX=9606 GN=PANK1 PE=1 SV=2" "0.000" "False" "12.230" "6" "4" "4" "1" "598" "64.3" "7.56" "10.60" "4" "other metabolic processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf03630" "53354" "ENSG00000152782" "PANK1" "A6NIP0; hsa:53354; Q7RTX6; Q7Z495; Q8TBQ8; Q8TE04" "" "Coenzyme A biosynthesis" "1" "0" "0.955" "1.136" "0.953" "0.967" "1.084" "1.052" "0.940" "0.992" "0.895" "72.8" "69.6" "82.7" "69.4" "70.4" "78.9" "76.6" "68.5" "72.2" "65.1" "" "" "" "" "" "" "" "" "" "" "65.5" "56.3" "74.8" "67.7" "58.1" "78.9" "57.3" "60.5" "64.6" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "986054919885634239" "False" "High" "IsMasterProtein" "Q9NQY0" "Bridging integrator 3 OS=Homo sapiens OX=9606 GN=BIN3 PE=1 SV=1" "0.000" "False" "12.222" "14" "4" "5" "4" "253" "29.6" "7.47" "13.53" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf03114" "55909" "ENSG00000147439" "BIN3" "hsa:55909; Q9BVG2; Q9NQY0; Q9NVY9" "" "" "0" "0" "0.969" "0.971" "0.977" "1.104" "0.914" "1.134" "1.248" "1.012" "1.550" "65.3" "63.3" "63.4" "63.8" "72.1" "59.7" "74.1" "81.5" "66.1" "101.2" "" "" "" "" "" "" "" "" "" "" "58.7" "51.2" "57.4" "62.3" "59.5" "59.7" "55.5" "72.0" "59.2" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5690407567518484702" "False" "High" "IsMasterProtein" "Q9HCS7" "Pre-mRNA-splicing factor SYF1 OS=Homo sapiens OX=9606 GN=XAB2 PE=1 SV=2" "0.000" "False" "12.202" "5" "4" "4" "4" "855" "99.9" "6.23" "13.80" "4" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes" "nucleus;other cell component" "" "Pf13181" "56949" "ENSG00000076924" "XAB2" "hsa:56949; Q8TET6; Q96HB0; Q96IW0; Q9HCS7; Q9NRG6; Q9ULP3" "Rett syndrome; Nucleotide excision repair in xeroderma pigmentosum" "mRNA Splicing - Major Pathway; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "7" "0" "0.887" "0.967" "0.814" "0.889" "0.939" "0.787" "0.794" "0.778" "2.642" "192.6" "170.9" "186.3" "156.9" "171.3" "181.0" "151.7" "153.0" "149.8" "509.1" "" "" "" "" "" "" "" "" "" "" "173.2" "138.3" "168.5" "153.1" "141.4" "181.0" "113.6" "135.2" "134.1" "181.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-317196890552299004" "False" "High" "IsMasterProtein" "Q9C0B9" "Zinc finger CCHC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZCCHC2 PE=1 SV=6" "0.000" "False" "12.191" "6" "4" "4" "4" "1178" "125.9" "7.01" "12.55" "4" "" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "54877" "ENSG00000141664" "ZCCHC2" "B2RPG6; hsa:54877; Q8N3S1; Q9C0B9; Q9NXF6" "" "" "0" "0" "0.938" "0.912" "1.397" "0.935" "1.185" "0.840" "0.993" "0.931" "1.162" "251.3" "235.7" "229.2" "351.0" "234.8" "297.7" "211.0" "249.5" "233.8" "292.1" "" "" "" "" "" "" "" "" "" "" "225.9" "190.7" "207.3" "342.6" "193.8" "297.7" "158.0" "220.4" "209.2" "104.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-768881656379736442" "False" "High" "IsMasterProtein" "Q9BT73" "Proteasome assembly chaperone 3 OS=Homo sapiens OX=9606 GN=PSMG3 PE=1 SV=1" "0.000" "False" "12.188" "30" "3" "4" "3" "122" "13.1" "7.88" "16.68" "3" "cell organization and biogenesis" "other cell component" "other molecular function" "Pf10178" "84262" "ENSG00000157778" "PSMG3" "A4D216; A8MPW2; hsa:84262; Q9BT73" "" "" "0" "0" "0.932" "0.896" "0.937" "0.942" "1.149" "0.954" "1.123" "0.944" "0.735" "68.9" "64.2" "61.8" "64.6" "64.9" "79.2" "65.7" "77.4" "65.1" "50.7" "" "" "" "" "" "" "" "" "" "" "62.0" "52.0" "55.9" "63.0" "53.6" "79.2" "49.2" "68.4" "58.2" "18.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8184976527645465360" "False" "High" "IsMasterProtein" "Q8N5M4" "Tetratricopeptide repeat protein 9C OS=Homo sapiens OX=9606 GN=TTC9C PE=1 SV=1" "0.000" "False" "12.135" "23" "4" "5" "4" "171" "20.0" "8.92" "13.10" "4" "" "" "" "Pf14559" "283237" "ENSG00000162222" "TTC9C" "hsa:283237; Q8N5M4; Q8WYY7" "" "" "0" "0" "0.993" "0.913" "1.084" "0.911" "1.040" "0.902" "0.952" "0.932" "1.030" "207.4" "205.9" "189.5" "224.8" "188.9" "215.8" "187.0" "197.5" "193.4" "213.6" "" "" "" "" "" "" "" "" "" "" "186.5" "166.6" "171.4" "219.5" "155.9" "215.8" "140.0" "174.4" "173.1" "76.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-13985934146586024" "False" "High" "IsMasterProtein" "Q9HB65" "RNA polymerase II elongation factor ELL3 OS=Homo sapiens OX=9606 GN=ELL3 PE=1 SV=2" "0.000" "False" "12.132" "10" "4" "5" "4" "397" "45.3" "6.06" "14.38" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf07303, Pf10390" "80237" "ENSG00000128886" "ELL3" "B3KQ66; B3KX08; hsa:80237; Q6I9Z7; Q9H634; Q9HB65" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.045" "1.074" "0.902" "1.004" "1.003" "1.021" "1.015" "0.901" "1.366" "330.1" "345.0" "354.5" "297.8" "331.6" "331.0" "337.0" "335.2" "297.3" "451.1" "" "" "" "" "" "" "" "" "" "" "296.8" "279.1" "320.6" "290.7" "273.6" "331.0" "252.4" "296.0" "266.0" "161.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8876035733125179295" "False" "High" "IsMasterProtein" "Q96D71" "RalBP1-associated Eps domain-containing protein 1 OS=Homo sapiens OX=9606 GN=REPS1 PE=1 SV=3" "0.000" "False" "12.117" "6" "4" "5" "4" "796" "86.6" "5.69" "18.47" "4" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12763" "85021" "ENSG00000135597" "REPS1" "B7ZBZ8; B7ZBZ9; B7ZC00; hsa:85021; J3KP76; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q96D71; Q9BXY9" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "1.444" "1.164" "1.102" "1.286" "1.448" "1.294" "1.060" "1.231" "2.227" "335.5" "484.6" "390.6" "369.8" "431.5" "485.8" "434.3" "355.7" "413.1" "747.1" "" "" "" "" "" "" "" "" "" "" "301.7" "392.1" "353.3" "361.0" "356.1" "485.8" "325.2" "314.2" "369.7" "266.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8021819990662325449" "False" "High" "IsMasterProtein" "O43760" "Synaptogyrin-2 OS=Homo sapiens OX=9606 GN=SYNGR2 PE=1 SV=1" "0.000" "False" "12.093" "16" "4" "4" "4" "224" "24.8" "4.94" "13.23" "4" "cell organization and biogenesis;transport" "other membranes;ER/Golgi;other cell component" "" "Pf01284" "9144" "ENSG00000108639" "SYNGR2" "hsa:9144; O43760; O43762; Q3KQZ2; Q658S7" "" "" "0" "0" "0.965" "0.991" "0.993" "0.930" "0.935" "0.985" "0.970" "1.022" "0.845" "483.8" "466.8" "479.2" "480.2" "449.9" "452.3" "476.7" "469.5" "494.2" "408.6" "" "" "" "" "" "" "" "" "" "" "434.9" "377.7" "433.5" "468.7" "371.2" "452.3" "357.0" "414.7" "442.2" "145.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8105981666538771075" "False" "High" "IsMasterProtein" "P80297" "Metallothionein-1X OS=Homo sapiens OX=9606 GN=MT1X PE=1 SV=1" "0.000" "False" "12.081" "33" "2" "5" "2" "61" "6.1" "7.96" "14.38" "2" "stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00131" "4501" "ENSG00000187193" "MT1X" "A8MUC7; hsa:4501; P80297" "Copper homeostasis; Zinc homeostasis; Oxidative stress response" "Metallothioneins bind metals" "4" "0" "0.985" "0.972" "0.834" "0.921" "0.955" "0.925" "0.969" "0.932" "0.727" "548.0" "539.9" "532.9" "456.9" "504.7" "523.6" "506.9" "530.8" "511.0" "398.6" "" "" "" "" "" "" "" "" "" "" "492.7" "436.9" "482.0" "446.0" "416.5" "523.6" "379.6" "468.8" "457.3" "142.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2332005078854859868" "False" "High" "IsMasterProtein" "Q9BWT6" "Meiotic nuclear division protein 1 homolog OS=Homo sapiens OX=9606 GN=MND1 PE=1 SV=1" "0.000" "False" "12.068" "18" "3" "4" "3" "205" "23.7" "8.19" "11.62" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism" "nucleus" "nucleic acid binding activity" "Pf03962, Pf18517" "84057" "ENSG00000121211" "MND1" "B2R5F9; hsa:84057; Q9BWT6" "Primary ovarian insufficiency" "Meiotic recombination" "2" "0" "1.065" "1.085" "1.045" "1.167" "1.098" "1.190" "1.102" "1.135" "1.294" "164.8" "175.5" "178.7" "172.1" "192.2" "181.0" "196.0" "181.6" "187.0" "213.2" "" "" "" "" "" "" "" "" "" "" "148.1" "142.0" "161.6" "168.0" "158.6" "181.0" "146.8" "160.4" "167.3" "76.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2885282100623052741" "False" "High" "IsMasterProtein" "Q8TAV0" "Protein FAM76A OS=Homo sapiens OX=9606 GN=FAM76A PE=1 SV=1" "0.000" "False" "12.057" "17" "6" "6" "5" "307" "35.0" "9.19" "14.55" "6" "" "nucleus" "" "Pf16046" "199870" "ENSG00000009780" "FAM76A" "B4DWT3; hsa:199870; O95565; O95566; Q8N7J5; Q8TAV0" "" "" "0" "0" "0.957" "1.032" "0.906" "1.023" "1.078" "0.930" "0.948" "0.987" "0.875" "581.6" "556.7" "600.2" "527.0" "595.2" "626.9" "540.8" "551.3" "574.3" "509.0" "" "" "" "" "" "" "" "" "" "" "522.9" "450.4" "542.9" "514.4" "491.2" "626.9" "404.9" "486.9" "513.9" "181.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2873927276967630041" "False" "High" "IsMasterProtein" "Q2TAZ0" "Autophagy-related protein 2 homolog A OS=Homo sapiens OX=9606 GN=ATG2A PE=1 SV=3" "0.000" "False" "12.050" "3" "5" "5" "5" "1938" "212.7" "5.88" "15.40" "5" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624" "23130" "ENSG00000110046" "ATG2A" "hsa:23130; O43154; Q14DM2; Q2TAZ0; Q6ZTV2; Q7Z6K8; Q8IVY5; Q8TAI8; Q96HH7" "Alzheimer's disease and miRNA effects; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Alzheimer's disease; ADHD and autism (ASD) linked metabolic pathways and SNP" "" "4" "0" "1.111" "1.026" "0.944" "1.160" "1.089" "1.055" "1.070" "1.043" "1.155" "288.7" "320.7" "296.2" "272.6" "334.9" "314.4" "304.5" "308.8" "301.1" "333.5" "" "" "" "" "" "" "" "" "" "" "259.6" "259.5" "267.9" "266.1" "276.3" "314.4" "228.0" "272.8" "269.4" "119.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4201760533929060036" "False" "High" "IsMasterProtein" "P63313" "Thymosin beta-10 OS=Homo sapiens OX=9606 GN=TMSB10 PE=1 SV=2" "0.000" "False" "12.026" "48" "4" "26" "2" "44" "5.0" "5.36" "78.18" "4" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "9168" "ENSG00000034510" "TMSB10" "hsa:9168; P13472; P63313; Q596K9" "VEGFA-VEGFR2 signaling; Extrafollicular and follicular B cell activation by SARS-CoV-2" "" "2" "2" "1.097" "0.991" "1.019" "0.942" "0.872" "0.979" "1.096" "0.910" "0.755" "4089.8" "4486.1" "4051.8" "4168.5" "3853.9" "3565.7" "4004.4" "4482.9" "3721.3" "3087.6" "" "" "" "" "" "" "" "" "" "" "3677.2" "3630.0" "3665.0" "4069.0" "3180.3" "3565.7" "2998.4" "3959.6" "3329.8" "1102.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-325919897552027140" "False" "High" "IsMasterProtein" "Q9NW08" "DNA-directed RNA polymerase III subunit RPC2 OS=Homo sapiens OX=9606 GN=POLR3B PE=1 SV=2" "0.000" "False" "12.008" "4" "5" "5" "5" "1133" "127.7" "8.50" "15.14" "5" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf04566, Pf04567" "55703" "ENSG00000013503" "POLR3B" "A8K6H0; B3KV73; F5H1E6; hsa:55703; Q9NW08; Q9NW59" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "1.050" "1.093" "0.957" "1.049" "1.026" "1.004" "0.956" "1.029" "1.692" "386.3" "405.5" "422.2" "369.7" "405.4" "396.5" "387.9" "369.3" "397.5" "653.9" "" "" "" "" "" "" "" "" "" "" "347.4" "328.1" "381.9" "360.9" "334.6" "396.5" "290.5" "326.2" "355.7" "233.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3307427478696066462" "False" "High" "IsMasterProtein" "Q96AJ9" "Vesicle transport through interaction with t-SNAREs homolog 1A OS=Homo sapiens OX=9606 GN=VTI1A PE=1 SV=2" "0.000" "False" "12.004" "19" "4" "4" "4" "217" "25.2" "6.40" "14.30" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "143187" "ENSG00000151532" "VTI1A" "A2A307; B4E137; hsa:143187; Q5W0D7; Q96AJ9" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.008" "0.990" "1.019" "1.045" "1.047" "1.054" "1.058" "0.985" "0.827" "368.6" "371.5" "365.0" "375.7" "385.2" "385.8" "388.7" "389.9" "363.2" "304.8" "" "" "" "" "" "" "" "" "" "" "331.4" "300.6" "330.1" "366.7" "317.9" "385.8" "291.0" "344.3" "325.0" "108.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "531745898464633118" "False" "High" "IsMasterProtein" "Q6P3S6" "F-box only protein 42 OS=Homo sapiens OX=9606 GN=FBXO42 PE=1 SV=1" "0.000" "False" "11.990" "6" "4" "4" "4" "717" "77.8" "7.43" "14.18" "4" "" "other cell component" "other molecular function" "Pf12937, Pf13415, Pf13854" "54455" "ENSG00000037637; ENSG00000291375" "FBXO42" "B3KP30; hsa:54455; Q5TEU8; Q6P3S6; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4" "" "" "0" "0" "1.136" "1.186" "1.054" "1.121" "1.204" "1.132" "0.969" "1.188" "1.081" "252.6" "286.9" "299.6" "266.3" "283.2" "304.1" "285.9" "244.7" "299.9" "273.1" "" "" "" "" "" "" "" "" "" "" "227.1" "232.1" "271.0" "260.0" "233.7" "304.1" "214.1" "216.1" "268.4" "97.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7873984446358378188" "False" "High" "IsMasterProtein" "Q6UUV9" "CREB-regulated transcription coactivator 1 OS=Homo sapiens OX=9606 GN=CRTC1 PE=1 SV=2" "0.000" "False" "11.982" "5" "2" "3" "2" "634" "67.3" "6.05" "11.15" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "23373" "ENSG00000105662" "CRTC1" "A6NMG5; hsa:23373; O75114; Q6UUV9; Q6Y3A3; Q7LDZ2; Q8IUL3; Q8IZ34; Q8IZL1; Q8N6W3; Q96AI8; Q9H801" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Mesodermal commitment pathway" "Heme signaling; Circadian Clock; Transcriptional activation of mitochondrial biogenesis" "5" "0" "1.109" "0.939" "0.994" "1.206" "1.132" "0.911" "1.220" "1.482" "1.535" "11.5" "12.8" "10.8" "11.5" "13.9" "13.1" "10.5" "14.1" "17.1" "17.7" "" "" "" "" "" "" "" "" "" "" "10.4" "10.4" "9.8" "11.2" "11.5" "13.1" "7.9" "12.4" "15.3" "6.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-496325283526098650" "False" "High" "IsMasterProtein" "O75427" "Leucine-rich repeat and calponin homology domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LRCH4 PE=1 SV=2" "0.000" "False" "11.975" "8" "3" "3" "3" "683" "73.4" "8.22" "15.56" "3" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus" "" "Pf00307, Pf13855" "4034" "ENSG00000077454" "LRCH4" "A4D2D5; hsa:4034; O75427; Q8WV85; Q96ID0" "" "" "0" "0" "1.173" "1.170" "1.131" "1.211" "1.278" "1.413" "1.033" "1.053" "2.870" "91.8" "107.7" "107.4" "103.9" "111.2" "117.4" "129.7" "94.8" "96.7" "263.5" "" "" "" "" "" "" "" "" "" "" "82.6" "87.1" "97.2" "101.4" "91.8" "117.4" "97.2" "83.8" "86.5" "94.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8922027540744871533" "False" "High" "IsMasterProtein" "Q9UHQ1" "Nuclear prelamin A recognition factor OS=Homo sapiens OX=9606 GN=NARF PE=1 SV=1" "0.000" "False" "11.969" "10" "3" "3" "3" "456" "51.1" "7.08" "13.48" "3" "" "cytoskeleton;nucleus" "other molecular function" "Pf02256, Pf02906" "26502" "ENSG00000141562" "NARF" "A6NCJ3; B3KPX2; hsa:26502; K4DI98; Q96AY9; Q9BWC6; Q9UHQ1" "Iron-sulfur cluster biogenesis" "" "1" "0" "1.085" "1.231" "1.098" "1.179" "1.191" "1.239" "1.066" "1.068" "1.098" "154.2" "167.3" "189.8" "169.4" "181.9" "183.7" "191.1" "164.4" "164.7" "169.4" "" "" "" "" "" "" "" "" "" "" "138.7" "135.4" "171.7" "165.3" "150.1" "183.7" "143.1" "145.2" "147.3" "60.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2485392268921902957" "False" "High" "IsMasterProtein" "Q6ZN54" "Differentially expressed in FDCP 8 homolog OS=Homo sapiens OX=9606 GN=DEF8 PE=1 SV=2" "0.000" "False" "11.967" "11" "4" "5" "4" "512" "58.7" "6.52" "16.30" "4" "other biological processes" "" "other molecular function" "Pf00130, Pf13901" "54849" "ENSG00000140995" "DEF8" "B3KT65; B4DK62; B4E0S9; B7Z3H6; H3BUG7; hsa:54849; Q6ZN54; Q8N8N3; Q9NXL0" "" "" "0" "0" "1.134" "1.037" "0.981" "1.266" "1.100" "1.309" "1.013" "1.042" "0.875" "167.0" "189.3" "173.2" "163.8" "211.5" "183.7" "218.6" "169.2" "173.9" "146.2" "" "" "" "" "" "" "" "" "" "" "150.1" "153.2" "156.7" "159.8" "174.5" "183.7" "163.7" "149.5" "155.6" "52.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-143757823348630571" "False" "High" "IsMasterProtein" "Q8IV08" "5'-3' exonuclease PLD3 OS=Homo sapiens OX=9606 GN=PLD3 PE=1 SV=1" "0.000" "False" "11.963" "8" "4" "5" "4" "490" "54.7" "6.47" "13.98" "4" "DNA metabolism;stress response;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf13918" "23646" "ENSG00000105223" "PLD3" "hsa:23646; Q8IV08; Q92853; Q9BW87" "" "Role of phospholipids in phagocytosis; Synthesis of PG" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1992212741193317441" "False" "High" "IsMasterProtein" "Q13247" "Serine/arginine-rich splicing factor 6 OS=Homo sapiens OX=9606 GN=SRSF6 PE=1 SV=2" "0.000" "False" "11.961" "10" "4" "6" "1" "344" "39.6" "11.43" "20.14" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "6431" "ENSG00000124193" "SRSF6" "B7Z6J3; E1P5W6; hsa:6431; Q13244; Q13245; Q13247; Q96J06; Q9UJB8; Q9Y3N7" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway; mRNA Splicing - Minor Pathway" "7" "0" "0.957" "1.176" "1.170" "0.859" "1.421" "1.083" "1.141" "0.907" "1.040" "108.0" "103.4" "127.0" "126.4" "92.8" "153.5" "117.0" "123.3" "98.0" "112.4" "" "" "" "" "" "" "" "" "" "" "97.1" "83.6" "114.9" "123.4" "76.6" "153.5" "87.6" "108.9" "87.7" "40.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-448736336253279631" "False" "High" "IsMasterProtein" "Q9Y2H0" "Disks large-associated protein 4 OS=Homo sapiens OX=9606 GN=DLGAP4 PE=1 SV=3" "0.000" "False" "11.957" "3" "4" "4" "4" "992" "107.9" "7.08" "16.32" "4" "other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf03359" "22839" "ENSG00000080845" "DLGAP4" "E1P5T5; hsa:22839; Q5QPG4; Q5T2Y4; Q5T2Y5; Q9H137; Q9H138; Q9H1L7; Q9Y2H0" "" "Neurexins and neuroligins" "1" "0" "0.941" "1.049" "1.042" "0.927" "1.018" "0.954" "1.029" "1.069" "0.840" "452.2" "425.4" "474.4" "471.1" "419.1" "460.2" "431.4" "465.5" "483.3" "379.8" "" "" "" "" "" "" "" "" "" "" "406.6" "344.3" "429.1" "459.8" "345.9" "460.2" "323.0" "411.2" "432.5" "135.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8890880560088896106" "False" "High" "IsMasterProtein" "Q8NFZ5" "TNFAIP3-interacting protein 2 OS=Homo sapiens OX=9606 GN=TNIP2 PE=1 SV=1" "0.000" "False" "11.956" "9" "4" "4" "4" "429" "48.7" "6.44" "12.93" "4" "stress response;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf12180" "79155" "ENSG00000168884" "TNIP2" "B1AKS4; B3KTY8; D3DVQ9; hsa:79155; Q7L5L2; Q8NFZ5; Q9BQR6; Q9H682" "RAC1/PAK1/p38/MMP2 pathway" "MAP3K8 (TPL2)-dependent MAPK1/3 activation; Ovarian tumor domain proteases" "3" "0" "0.913" "0.960" "0.904" "0.952" "0.853" "0.970" "0.950" "0.905" "1.475" "100.4" "91.7" "96.4" "90.8" "95.6" "85.6" "97.4" "95.4" "90.9" "148.2" "" "" "" "" "" "" "" "" "" "" "90.3" "74.2" "87.2" "88.6" "78.9" "85.6" "73.0" "84.3" "81.3" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "251219974824346079" "False" "High" "IsMasterProtein" "Q05D32" "CTD small phosphatase-like protein 2 OS=Homo sapiens OX=9606 GN=CTDSPL2 PE=1 SV=2" "0.000" "False" "11.946" "7" "3" "5" "3" "466" "53.0" "6.40" "11.28" "3" "transport;other biological processes" "nucleus" "other molecular function" "Pf03031" "51496" "ENSG00000137770" "CTDSPL2" "hsa:51496; Q05D32; Q3ZTU1; Q6AI06; Q8IYI9; Q9NVT2; Q9NZX8; Q9P030" "" "" "0" "0" "0.960" "0.988" "0.896" "1.032" "1.001" "1.172" "1.020" "0.981" "1.102" "85.5" "82.1" "84.5" "76.6" "88.2" "85.5" "100.2" "87.1" "83.8" "94.2" "" "" "" "" "" "" "" "" "" "" "76.9" "66.4" "76.4" "74.7" "72.8" "85.5" "75.0" "77.0" "75.0" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5402441647647125323" "False" "High" "IsMasterProtein" "O75880" "Protein SCO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO1 PE=1 SV=1" "0.000" "False" "11.946" "11" "4" "6" "4" "301" "33.8" "8.88" "16.94" "4" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "6341" "ENSG00000133028" "SCO1" "B2RDM0; hsa:6341; O75880" "Electron transport chain: OXPHOS system in mitochondria; Copper homeostasis" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "5" "0" "0.992" "1.035" "0.860" "0.990" "1.008" "0.862" "1.098" "1.098" "0.768" "452.3" "448.8" "468.4" "389.1" "447.7" "455.8" "389.9" "496.9" "496.6" "347.6" "" "" "" "" "" "" "" "" "" "" "406.7" "363.1" "423.7" "379.9" "369.4" "455.8" "292.0" "438.9" "444.4" "124.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2217826250867961619" "False" "High" "IsMasterProtein" "Q6P4F2" "Ferredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=FDX2 PE=1 SV=3" "0.000" "False" "11.939" "26" "3" "3" "3" "183" "19.5" "5.38" "12.32" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00111" "112812" "ENSG00000267673" "FDX2" "B7Z6L7; Q6P4F2; Q8N8B8" "" "Endogenous sterols; Pregnenolone biosynthesis; Defective CYP11A1 causes AICSR; Electron transport from NADPH to Ferredoxin" "5" "0" "1.132" "1.002" "0.942" "1.025" "1.120" "1.075" "1.080" "1.015" "0.861" "235.7" "266.7" "236.1" "222.0" "241.6" "263.9" "253.4" "254.6" "239.2" "203.0" "" "" "" "" "" "" "" "" "" "" "211.9" "215.8" "213.5" "216.7" "199.4" "263.9" "189.7" "224.9" "214.0" "72.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4361926129006051556" "False" "High" "IsMasterProtein" "Q9BSH4" "Translational activator of cytochrome c oxidase 1 OS=Homo sapiens OX=9606 GN=TACO1 PE=1 SV=1" "0.000" "False" "11.923" "11" "3" "3" "3" "297" "32.5" "8.13" "12.22" "3" "cell organization and biogenesis;other biological processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf01709, Pf20772" "51204" "ENSG00000136463" "TACO1" "B2RD21; hsa:51204; Q8N3N6; Q9BSH4; Q9UI60" "Mitochondrial complex IV assembly" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "4" "0" "0.979" "1.087" "0.877" "1.048" "1.042" "1.141" "0.925" "0.911" "1.833" "84.4" "82.6" "91.7" "74.0" "88.4" "87.9" "96.3" "78.1" "76.9" "154.7" "" "" "" "" "" "" "" "" "" "" "75.9" "66.8" "82.9" "72.3" "73.0" "87.9" "72.1" "68.9" "68.8" "55.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3376743551660886452" "False" "High" "IsMasterProtein" "Q8N5L8" "Ribonuclease P protein subunit p25-like protein OS=Homo sapiens OX=9606 GN=RPP25L PE=1 SV=1" "0.000" "False" "11.912" "25" "3" "3" "3" "163" "17.6" "10.30" "12.73" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf01918" "138716" "ENSG00000164967" "RPP25L" "D3DRM5; hsa:138716; Q8N5L8" "" "" "0" "0" "0.988" "0.993" "0.917" "1.022" "1.091" "1.049" "0.946" "1.069" "0.934" "457.5" "452.1" "454.5" "419.8" "467.4" "499.2" "479.8" "432.9" "489.3" "427.1" "" "" "" "" "" "" "" "" "" "" "411.4" "365.8" "411.1" "409.8" "385.7" "499.2" "359.3" "382.4" "437.8" "152.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6229866583710047273" "False" "High" "IsMasterProtein" "Q96C23" "Galactose mutarotase OS=Homo sapiens OX=9606 GN=GALM PE=1 SV=1" "0.000" "False" "11.910" "11" "3" "3" "3" "342" "37.7" "6.65" "12.72" "3" "other metabolic processes" "other cell component" "other molecular function" "Pf01263" "130589" "ENSG00000143891" "GALM" "hsa:130589; Q53RY1; Q8NIA2; Q96C23; V9HWA8" "" "" "0" "0" "1.037" "1.047" "1.053" "1.173" "1.161" "1.175" "1.057" "1.004" "1.276" "196.8" "204.1" "206.1" "207.2" "230.8" "228.5" "231.2" "208.1" "197.5" "251.2" "" "" "" "" "" "" "" "" "" "" "177.0" "165.2" "186.4" "202.2" "190.5" "228.5" "173.1" "183.8" "176.7" "89.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7703205907594076097" "False" "High" "IsMasterProtein" "Q12982" "BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 OS=Homo sapiens OX=9606 GN=BNIP2 PE=1 SV=1" "0.000" "False" "11.908" "11" "4" "4" "4" "314" "36.0" "4.81" "15.02" "4" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf12496, Pf13716" "663" "ENSG00000140299" "BNIP2" "B4DS94; hsa:663; Q12982" "Acute viral myocarditis" "Myogenesis" "2" "0" "0.969" "0.902" "0.924" "1.037" "0.914" "1.077" "1.023" "0.959" "0.878" "439.6" "425.9" "396.6" "406.4" "455.8" "401.8" "473.2" "449.5" "421.5" "385.8" "" "" "" "" "" "" "" "" "" "" "395.2" "344.6" "358.8" "396.7" "376.2" "401.8" "354.3" "397.0" "377.2" "137.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7880299812085229449" "False" "High" "IsMasterProtein" "P11049" "Leukocyte antigen CD37 OS=Homo sapiens OX=9606 GN=CD37 PE=1 SV=2" "0.000" "False" "11.881" "17" "4" "4" "4" "281" "31.7" "7.94" "16.24" "4" "" "plasma membrane" "" "Pf00335" "951" "ENSG00000104894" "CD37" "B4DVC1; hsa:951; P11049; Q3KPF9" "TYROBP causal network in microglia" "" "1" "0" "1.012" "0.887" "1.070" "0.976" "0.850" "0.974" "1.048" "0.987" "0.736" "341.2" "345.3" "302.7" "364.9" "333.0" "290.1" "332.5" "357.7" "336.9" "251.0" "" "" "" "" "" "" "" "" "" "" "306.8" "279.4" "273.8" "356.2" "274.8" "290.1" "248.9" "315.9" "301.5" "89.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-428002072210945893" "False" "High" "IsMasterProtein" "P52657" "Transcription initiation factor IIA subunit 2 OS=Homo sapiens OX=9606 GN=GTF2A2 PE=1 SV=1" "0.000" "False" "11.874" "28" "4" "5" "4" "109" "12.4" "6.62" "14.54" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf02268, Pf02751" "2958" "ENSG00000140307" "GTF2A2" "A8MYQ7; hsa:2958; P52657; Q6FGB5" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "11" "0" "1.097" "0.989" "0.970" "1.147" "1.013" "1.152" "1.073" "1.005" "0.955" "377.6" "414.0" "373.4" "366.4" "433.0" "382.6" "435.1" "405.0" "379.4" "360.5" "" "" "" "" "" "" "" "" "" "" "339.5" "335.0" "337.8" "357.6" "357.3" "382.6" "325.8" "357.7" "339.4" "128.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6751278663907923034" "False" "High" "IsMasterProtein" "Q9UFG5" "UPF0449 protein C19orf25 OS=Homo sapiens OX=9606 GN=C19orf25 PE=1 SV=2" "0.000" "False" "11.840" "39" "3" "6" "3" "118" "12.9" "5.07" "27.90" "3" "" "" "" "Pf15136" "148223" "ENSG00000119559" "C19orf25" "B3KQN6; hsa:148223; Q8N9R7; Q8WV94; Q9UFG5" "" "" "0" "0" "1.003" "1.067" "0.905" "0.957" "1.138" "1.016" "1.038" "1.078" "1.097" "385.2" "386.3" "411.1" "348.5" "368.6" "438.3" "391.5" "399.8" "415.2" "422.6" "" "" "" "" "" "" "" "" "" "" "346.3" "312.6" "371.9" "340.2" "304.2" "438.3" "293.1" "353.1" "371.5" "150.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4571084566871798353" "False" "High" "IsMasterProtein" "Q9Y2S6" "Translation machinery-associated protein 7 OS=Homo sapiens OX=9606 GN=TMA7 PE=1 SV=1" "0.000" "False" "11.840" "25" "2" "11" "2" "64" "7.1" "9.99" "29.78" "2" "" "" "" "Pf09072" "51372" "ENSG00000232112" "TMA7" "hsa:51372; Q9P052; Q9Y2S6" "" "" "0" "0" "1.001" "0.920" "0.967" "0.907" "0.963" "1.007" "1.038" "0.908" "0.665" "1749.1" "1751.5" "1608.3" "1690.9" "1586.9" "1684.2" "1761.0" "1815.0" "1588.2" "1164.0" "" "" "" "" "" "" "" "" "" "" "1572.6" "1417.2" "1454.8" "1650.5" "1309.6" "1684.2" "1318.6" "1603.1" "1421.1" "415.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6043879365308815932" "False" "High" "IsMasterProtein" "O75818" "Ribonuclease P protein subunit p40 OS=Homo sapiens OX=9606 GN=RPP40 PE=1 SV=3" "0.000" "False" "11.831" "12" "4" "6" "4" "363" "41.8" "6.67" "24.63" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08584" "10799" "ENSG00000124787" "RPP40" "hsa:10799; O75818; Q5VX97; Q8WVK8" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.083" "1.066" "0.945" "1.023" "1.004" "0.981" "1.035" "1.041" "0.848" "489.1" "529.5" "521.6" "462.2" "500.5" "491.1" "479.8" "506.4" "509.2" "414.6" "" "" "" "" "" "" "" "" "" "" "439.7" "428.5" "471.8" "451.1" "413.0" "491.1" "359.3" "447.3" "455.7" "148.0" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "451284985450217438" "False" "High" "IsMasterProtein" "Q9NVV4" "Poly(A) RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=MTPAP PE=1 SV=1" "0.000" "False" "11.824" "9" "5" "5" "5" "582" "66.1" "9.04" "18.56" "5" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf03828, Pf17797" "55149" "ENSG00000107951" "MTPAP" "D3DRX0; hsa:55149; Q659E3; Q6P7E5; Q9HA74; Q9NVV4" "" "" "0" "0" "1.064" "0.938" "0.854" "0.947" "1.415" "0.905" "0.807" "0.829" "0.902" "320.5" "341.0" "300.6" "273.7" "303.5" "453.6" "290.0" "258.6" "265.6" "289.0" "" "" "" "" "" "" "" "" "" "" "288.1" "275.9" "271.9" "267.2" "250.5" "453.6" "217.2" "228.4" "237.6" "103.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8049844811418031107" "False" "High" "IsMasterProtein" "O95707" "Ribonuclease P protein subunit p29 OS=Homo sapiens OX=9606 GN=POP4 PE=1 SV=2" "0.000" "False" "11.790" "10" "2" "4" "2" "220" "25.4" "10.07" "13.58" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01868" "10775" "ENSG00000105171" "POP4" "hsa:10775; O95707; Q5XKL7; Q6FHW9; Q9UQQ3" "" "tRNA processing in the nucleus" "1" "0" "0.929" "0.803" "0.921" "0.846" "0.807" "0.926" "0.824" "0.933" "0.797" "104.1" "96.7" "83.6" "95.9" "88.1" "84.0" "96.4" "85.7" "97.2" "83.0" "" "" "" "" "" "" "" "" "" "" "93.6" "78.2" "75.6" "93.6" "72.7" "84.0" "72.2" "75.7" "86.9" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036196760614096612" "False" "High" "IsMasterProtein" "P11802" "Cyclin-dependent kinase 4 OS=Homo sapiens OX=9606 GN=CDK4 PE=1 SV=2" "0.000" "False" "11.781" "13" "3" "5" "2" "303" "33.7" "7.01" "18.96" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "1019" "ENSG00000135446" "CDK4" "B2R9A0; B4DNF9; hsa:1019; O00576; P11802; Q6FG61" "miRNA regulation of DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Spinal cord injury; Retinoblastoma gene in cancer; Bladder cancer; PPAR-alpha pathway; Nuclear receptors meta-pathway; Ovarian infertility; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; PI3K-Akt signaling pathway; Tumor suppressor activity of SMARCB1; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Sphingolipid metabolism in senescence; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; JAK-STAT signaling in the regulation of beta cells; DNA damage response" "Ubiquitin-dependent degradation of Cyclin D; SCF(Skp2)-mediated degradation of p27/p21; Oxidative Stress Induced Senescence; Transcriptional regulation of white adipocyte differentiation; Oncogene Induced Senescence; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); Senescence-Associated Secretory Phenotype (SASP); RMTs methylate histone arginines; Transcriptional regulation by RUNX2; Meiotic recombination; Transcriptional regulation of granulopoiesis; PTK6 Regulates Cell Cycle; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4; Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6; Drug-mediated inhibition of CDK4/CDK6 activity" "47" "0" "1.053" "1.148" "1.173" "1.103" "1.011" "1.187" "1.107" "1.174" "1.811" "110.4" "116.3" "126.8" "129.5" "121.8" "111.6" "131.0" "122.2" "129.6" "199.9" "" "" "" "" "" "" "" "" "" "" "99.2" "94.1" "114.7" "126.4" "100.5" "111.6" "98.1" "107.9" "116.0" "71.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1550632578398820844" "False" "High" "IsMasterProtein" "Q8N3P4" "Vacuolar protein sorting-associated protein 8 homolog OS=Homo sapiens OX=9606 GN=VPS8 PE=1 SV=3" "0.000" "False" "11.765" "3" "5" "5" "5" "1428" "161.7" "5.64" "16.30" "5" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf12816" "23355" "ENSG00000156931" "VPS8" "A8K8Q8; B9EIQ1; C9JB61; hsa:23355; O94896; Q63HP2; Q8N3P4; Q9BVP9; Q9H9B0" "" "" "0" "0" "0.960" "1.053" "0.902" "0.994" "0.952" "1.041" "0.981" "1.064" "1.659" "302.6" "290.5" "318.6" "272.9" "300.7" "288.0" "315.0" "297.0" "322.1" "502.0" "" "" "" "" "" "" "" "" "" "" "272.1" "235.1" "288.2" "266.4" "248.2" "288.0" "235.8" "262.3" "288.2" "179.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1727135258656817627" "False" "High" "IsMasterProtein" "Q9BTL3" "RNA guanine-N7 methyltransferase activating subunit OS=Homo sapiens OX=9606 GN=RAMAC PE=1 SV=1" "0.000" "False" "11.763" "35" "4" "5" "4" "118" "14.4" "8.94" "20.53" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15320" "83640" "ENSG00000169612" "RAMAC" "hsa:83640; Q2M1J8; Q9BTL3" "15q25 copy number variation" "" "1" "0" "0.936" "0.955" "0.931" "0.879" "0.966" "1.022" "0.833" "0.935" "0.828" "111.8" "104.7" "106.7" "104.1" "98.3" "108.0" "114.2" "93.1" "104.5" "92.6" "" "" "" "" "" "" "" "" "" "" "100.5" "84.7" "96.6" "101.6" "81.1" "108.0" "85.5" "82.3" "93.5" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8583026759934693939" "False" "High" "IsMasterProtein" "Q9P1Z2" "Calcium-binding and coiled-coil domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CALCOCO1 PE=1 SV=2" "0.000" "False" "11.747" "6" "4" "4" "4" "691" "77.3" "4.82" "12.74" "4" "cell-cell signaling;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07888, Pf17751, Pf18112" "57658" "ENSG00000012822" "CALCOCO1" "B3KVA8; hsa:57658; Q6FI59; Q71RC3; Q86WF8; Q96JU3; Q9H090; Q9P1Z2" "" "" "0" "0" "0.969" "0.989" "1.017" "1.006" "0.994" "1.065" "1.039" "0.970" "1.121" "342.7" "331.9" "338.7" "348.6" "344.7" "340.8" "364.9" "356.2" "332.5" "384.0" "" "" "" "" "" "" "" "" "" "" "308.1" "268.6" "306.4" "340.2" "284.5" "340.8" "273.2" "314.6" "297.5" "137.1" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4255183124898333384" "False" "High" "IsMasterProtein" "Q9Y6G5" "COMM domain-containing protein 10 OS=Homo sapiens OX=9606 GN=COMMD10 PE=1 SV=1" "0.000" "False" "11.721" "18" "3" "3" "3" "202" "23.0" "6.54" "12.72" "3" "" "nucleus;other cell component" "" "Pf07258, Pf21672" "51397" "ENSG00000145781" "COMMD10" "D3DT07; hsa:51397; Q9P077; Q9Y6G5" "" "Neddylation" "1" "0" "1.018" "0.901" "1.008" "1.107" "0.968" "1.018" "1.045" "0.954" "1.052" "257.9" "262.5" "232.4" "259.8" "285.5" "249.7" "262.5" "269.4" "245.9" "271.2" "" "" "" "" "" "" "" "" "" "" "231.8" "212.4" "210.2" "253.6" "235.6" "249.7" "196.5" "238.0" "220.1" "96.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492559823843858039" "False" "High" "IsMasterProtein" "Q6ZW49" "PAX-interacting protein 1 OS=Homo sapiens OX=9606 GN=PAXIP1 PE=1 SV=2" "0.000" "False" "11.719" "3" "3" "4" "3" "1069" "121.3" "6.70" "12.92" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf00533, Pf12738, Pf16589" "22976" "ENSG00000157212" "PAXIP1" "hsa:22976; O15404; Q6N099; Q6ZW49; Q6ZWH9; Q7Z315; Q86UN0; Q8N4P9; Q96HP2" "16p11.2 proximal deletion syndrome; SMC1/SMC3 role in DNA damage - Cornelia de Lange Syndrome; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Nonhomologous End-Joining (NHEJ)" "6" "0" "1.115" "1.089" "1.057" "1.094" "1.306" "1.172" "1.222" "1.102" "1.210" "117.8" "131.3" "128.2" "124.5" "128.9" "153.8" "138.0" "143.9" "129.8" "142.5" "" "" "" "" "" "" "" "" "" "" "105.9" "106.2" "116.0" "121.5" "106.3" "153.8" "103.3" "127.1" "116.1" "50.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2733253045392511170" "False" "High" "IsMasterProtein" "P23297" "Protein S100-A1 OS=Homo sapiens OX=9606 GN=S100A1 PE=1 SV=2" "0.000" "False" "11.692" "23" "2" "4" "2" "94" "10.5" "4.50" "17.69" "2" "signal transduction;other biological processes" "non-structural extracellular;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00036, Pf01023" "6271" "ENSG00000160678" "S100A1" "B2R5D9; hsa:6271; P23297; Q5T7Y3" "" "ER-Phagosome pathway; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); Regulation of TLR by endogenous ligand" "5" "0" "0.972" "0.804" "0.948" "0.906" "0.930" "0.966" "0.993" "0.950" "0.764" "446.9" "434.3" "359.2" "423.5" "404.9" "415.7" "431.9" "443.9" "424.6" "341.3" "" "" "" "" "" "" "" "" "" "" "401.8" "351.5" "324.9" "413.4" "334.1" "415.7" "323.4" "392.1" "379.9" "121.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1645614495321622240" "False" "High" "IsMasterProtein" "P57678" "Gem-associated protein 4 OS=Homo sapiens OX=9606 GN=GEMIN4 PE=1 SV=2" "0.000" "False" "11.692" "3" "3" "3" "3" "1058" "120.0" "6.04" "11.93" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "50628" "ENSG00000179409" "GEMIN4" "hsa:50628; P57678; Q9NZS7; Q9UG32; Q9Y4Q2" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "0.953" "0.853" "0.837" "0.889" "0.855" "0.890" "0.885" "0.902" "1.993" "185.4" "176.7" "158.1" "155.2" "164.7" "158.5" "165.1" "164.0" "167.2" "369.6" "" "" "" "" "" "" "" "" "" "" "166.7" "143.0" "143.0" "151.5" "135.9" "158.5" "123.6" "144.8" "149.6" "131.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5476878865190536687" "False" "High" "IsMasterProtein" "Q14693" "Phosphatidate phosphatase LPIN1 OS=Homo sapiens OX=9606 GN=LPIN1 PE=1 SV=2" "0.000" "False" "11.682" "7" "5" "5" "5" "890" "98.6" "6.58" "16.61" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf04571, Pf08235, Pf16876" "23175" "ENSG00000134324" "LPIN1" "A8MU38; B4DET9; B4DGS4; B4DGZ6; B5MC18; B7Z858; D6W506; E7ESE7; F5GY24; hsa:23175; Q14693; Q53T25" "Sterol regulatory element-binding proteins (SREBP) signaling; Adipogenesis; Transcription factor regulation in adipogenesis; Congenital generalized lipodystrophy" "Triglyceride biosynthesis; Depolymerization of the Nuclear Lamina; Synthesis of PC; Synthesis of PE" "8" "0" "1.050" "0.950" "0.915" "1.004" "0.939" "1.035" "0.956" "0.906" "0.846" "463.9" "487.1" "440.7" "424.5" "465.8" "435.9" "480.3" "443.7" "420.5" "392.6" "" "" "" "" "" "" "" "" "" "" "417.1" "394.1" "398.7" "414.3" "384.4" "435.9" "359.6" "391.9" "376.2" "140.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5153140893326454359" "False" "High" "IsMasterProtein" "Q99496" "E3 ubiquitin-protein ligase RING2 OS=Homo sapiens OX=9606 GN=RNF2 PE=1 SV=1" "0.000" "False" "11.669" "14" "4" "5" "4" "336" "37.6" "6.84" "17.91" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf16207" "6045" "ENSG00000121481" "RNF2" "B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; Q99496" "FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "11" "0" "1.142" "1.130" "0.948" "1.166" "1.155" "1.194" "1.050" "1.102" "1.035" "203.8" "232.7" "230.3" "193.1" "237.6" "235.3" "243.3" "213.9" "224.6" "210.8" "" "" "" "" "" "" "" "" "" "" "183.2" "188.3" "208.3" "188.5" "196.0" "235.3" "182.2" "188.9" "201.0" "75.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3522483334195236405" "False" "High" "IsMasterProtein" "Q13542" "Eukaryotic translation initiation factor 4E-binding protein 2 OS=Homo sapiens OX=9606 GN=EIF4EBP2 PE=1 SV=1" "0.000" "False" "11.647" "23" "2" "4" "2" "120" "12.9" "6.67" "13.44" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05456" "1979" "ENSG00000148730" "EIF4EBP2" "hsa:1979; Q13542" "Translation factors; Fragile X syndrome" "" "2" "0" "0.977" "0.911" "0.958" "0.929" "0.983" "0.943" "0.980" "0.864" "0.900" "284.9" "278.3" "259.5" "273.0" "264.7" "280.0" "268.7" "279.2" "246.1" "256.5" "" "" "" "" "" "" "" "" "" "" "256.2" "225.2" "234.7" "266.5" "218.5" "280.0" "201.2" "246.6" "220.2" "91.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8590031244663879657" "False" "High" "IsMasterProtein" "P47224" "Guanine nucleotide exchange factor MSS4 OS=Homo sapiens OX=9606 GN=RABIF PE=1 SV=2" "0.000" "False" "11.646" "25" "2" "3" "2" "123" "13.8" "5.52" "15.34" "2" "cell organization and biogenesis;transport;signal transduction" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf04421" "5877" "ENSG00000183155" "RABIF" "B2R4P4; hsa:5877; P47224; Q92992" "Retinoblastoma gene in cancer" "" "1" "0" "0.972" "1.057" "0.952" "0.977" "1.129" "1.062" "1.114" "1.162" "0.999" "256.6" "249.5" "271.2" "244.4" "250.7" "289.6" "272.6" "285.7" "298.1" "256.5" "" "" "" "" "" "" "" "" "" "" "230.7" "201.9" "245.3" "238.6" "206.9" "289.6" "204.1" "252.4" "266.7" "91.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1058846499056220573" "False" "High" "IsMasterProtein" "Q96CP2" "FLYWCH family member 2 OS=Homo sapiens OX=9606 GN=FLYWCH2 PE=1 SV=1" "0.000" "False" "11.641" "22" "3" "4" "3" "140" "14.6" "8.46" "16.31" "3" "" "" "" "Pf15423" "114984" "ENSG00000162076" "FLYWCH2" "hsa:114984; Q96CP2" "" "" "0" "0" "1.092" "1.225" "1.124" "1.150" "1.274" "1.189" "1.264" "1.243" "1.064" "284.2" "310.5" "348.3" "319.6" "326.9" "362.1" "337.9" "359.2" "353.4" "302.5" "" "" "" "" "" "" "" "" "" "" "255.6" "251.2" "315.1" "312.0" "269.8" "362.1" "253.0" "317.3" "316.2" "108.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7338672527715775280" "False" "High" "IsMasterProtein" "Q8IWL3" "Iron-sulfur cluster co-chaperone protein HscB OS=Homo sapiens OX=9606 GN=HSCB PE=1 SV=3" "0.000" "False" "11.640" "17" "5" "6" "5" "235" "27.4" "7.69" "14.78" "5" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf07743, Pf18256" "150274" "ENSG00000100209" "HSCB" "hsa:150274; Q8IWL3; Q9BWS7" "Iron-sulfur cluster biogenesis" "Mitochondrial protein import; Mitochondrial iron-sulfur cluster biogenesis" "3" "0" "0.917" "0.968" "0.936" "0.796" "0.992" "0.876" "0.922" "0.941" "1.083" "115.0" "105.4" "111.3" "107.6" "91.5" "114.1" "100.7" "106.0" "108.2" "124.5" "" "" "" "" "" "" "" "" "" "" "103.4" "85.3" "100.6" "105.1" "75.5" "114.1" "75.4" "93.6" "96.8" "44.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8559290960834017297" "False" "High" "IsMasterProtein" "O14976" "Cyclin-G-associated kinase OS=Homo sapiens OX=9606 GN=GAK PE=1 SV=2" "0.000" "False" "11.631" "3" "4" "5" "4" "1311" "143.1" "5.73" "12.57" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00069, Pf10409" "2580" "ENSG00000178950" "GAK" "hsa:2580; O14976; Q5U4P5; Q9BVY6" "" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis" "2" "0" "1.350" "1.482" "1.894" "1.081" "1.372" "1.299" "1.188" "1.363" "0.920" "96.9" "130.9" "143.6" "183.5" "104.8" "132.9" "125.9" "115.1" "132.1" "89.2" "" "" "" "" "" "" "" "" "" "" "87.1" "105.9" "129.9" "179.1" "86.5" "132.9" "94.3" "101.7" "118.2" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8412715806264131259" "False" "High" "IsMasterProtein" "Q5F1R6" "DnaJ homolog subfamily C member 21 OS=Homo sapiens OX=9606 GN=DNAJC21 PE=1 SV=2" "0.000" "False" "11.626" "8" "4" "4" "4" "531" "62.0" "5.47" "12.87" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00226, Pf12171" "134218" "ENSG00000168724" "DNAJC21" "Q3B7J9; Q5F1R6; Q6P086; Q6ZS43; Q86VC6" "" "" "0" "0" "1.025" "1.138" "0.918" "1.027" "1.169" "0.991" "0.918" "1.113" "1.077" "273.3" "280.1" "311.0" "250.8" "280.7" "319.4" "270.8" "250.9" "304.2" "294.3" "" "" "" "" "" "" "" "" "" "" "245.7" "226.7" "281.3" "244.8" "231.6" "319.4" "202.8" "221.6" "272.2" "105.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2524487954234531318" "False" "High" "IsMasterProtein" "Q9Y6N7" "Roundabout homolog 1 OS=Homo sapiens OX=9606 GN=ROBO1 PE=1 SV=1" "0.000" "False" "11.618" "3" "4" "4" "4" "1651" "180.8" "6.04" "12.20" "4" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00041, Pf07679, Pf13927" "6091" "ENSG00000169855" "ROBO1" "B2RXI1; D3DU36; E9PD49; hsa:6091; Q1RMC7; Q7Z300; Q9BUS7; Q9Y6N7" "Development of ureteric collection system; Cell lineage map for neuronal differentiation" "Regulation of commissural axon pathfinding by SLIT and ROBO; Regulation of expression of SLITs and ROBOs; Netrin-1 signaling; Inactivation of CDC42 and RAC1; Activation of RAC1; Regulation of cortical dendrite branching; Role of ABL in ROBO-SLIT signaling; SLIT2:ROBO1 increases RHOA activity" "11" "0" "1.284" "1.019" "1.351" "1.130" "1.172" "1.346" "1.164" "1.210" "1.026" "146.0" "187.5" "148.8" "197.2" "165.0" "171.1" "196.6" "170.0" "176.7" "149.8" "" "" "" "" "" "" "" "" "" "" "131.3" "151.7" "134.6" "192.5" "136.1" "171.1" "147.2" "150.2" "158.1" "53.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7918333957511705273" "False" "High" "IsMasterProtein" "Q68D20" "Protein PMS2CL OS=Homo sapiens OX=9606 GN=PMS2CL PE=1 SV=1" "0.000" "False" "11.605" "13" "2" "3" "1" "193" "20.9" "5.34" "10.42" "2" "" "" "" "" "" "" "PMS2CL" "B4DK88; Q68D20; Q764P1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5380197694992633096" "False" "High" "IsMasterProtein" "Q9BWG4" "Single-stranded DNA-binding protein 4 OS=Homo sapiens OX=9606 GN=SSBP4 PE=1 SV=1" "0.000" "False" "11.601" "10" "3" "4" "2" "385" "39.4" "6.80" "15.17" "3" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04503" "170463" "ENSG00000130511" "SSBP4" "hsa:170463; Q9BWG4; Q9BWW5" "" "" "0" "0" "0.930" "0.880" "0.809" "0.934" "0.868" "0.943" "1.109" "0.889" "0.794" "152.3" "141.7" "134.0" "123.2" "142.3" "132.3" "143.7" "168.9" "135.4" "121.0" "" "" "" "" "" "" "" "" "" "" "137.0" "114.7" "121.2" "120.2" "117.4" "132.3" "107.6" "149.2" "121.1" "43.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3741910088829308609" "False" "High" "IsMasterProtein" "Q9NP66" "High mobility group protein 20A OS=Homo sapiens OX=9606 GN=HMG20A PE=1 SV=1" "0.000" "False" "11.599" "15" "5" "6" "5" "347" "40.1" "6.49" "15.90" "5" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505" "10363" "ENSG00000140382" "HMG20A" "A6NHY3; D3DW78; hsa:10363; Q53G31; Q9NP66; Q9NSF6" "" "" "0" "0" "0.920" "0.989" "0.812" "0.978" "0.934" "0.884" "0.906" "0.907" "1.262" "333.3" "306.6" "329.8" "270.7" "325.8" "311.4" "294.8" "302.0" "302.5" "420.8" "" "" "" "" "" "" "" "" "" "" "299.7" "248.1" "298.3" "264.3" "268.9" "311.4" "220.7" "266.8" "270.7" "150.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4022401648324513827" "False" "High" "IsMasterProtein" "Q9H6W3" "Ribosomal oxygenase 1 OS=Homo sapiens OX=9606 GN=RIOX1 PE=1 SV=2" "0.000" "False" "11.596" "6" "3" "3" "3" "641" "71.0" "6.46" "12.50" "3" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf08007, Pf21233" "79697" "ENSG00000170468" "RIOX1" "B4DT02; hsa:79697; Q9H6W3" "" "Protein hydroxylation" "1" "0" "1.062" "1.074" "0.869" "1.040" "1.093" "1.083" "1.021" "1.066" "0.989" "114.4" "121.5" "122.9" "99.4" "119.0" "125.0" "123.9" "116.8" "121.9" "113.1" "" "" "" "" "" "" "" "" "" "" "102.9" "98.3" "111.2" "97.1" "98.2" "125.0" "92.8" "103.1" "109.1" "40.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2792434032950857374" "False" "High" "IsMasterProtein" "Q96HR3" "Mediator of RNA polymerase II transcription subunit 30 OS=Homo sapiens OX=9606 GN=MED30 PE=1 SV=1" "0.000" "False" "11.588" "20" "4" "4" "4" "178" "20.3" "8.27" "10.84" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11315" "90390" "ENSG00000164758" "MED30" "C6GKU9; hsa:90390; Q96HR3" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.163" "0.992" "0.796" "1.370" "1.326" "1.230" "1.080" "1.218" "0.960" "96.9" "112.8" "96.1" "77.1" "132.8" "128.5" "119.2" "104.7" "118.1" "93.1" "" "" "" "" "" "" "" "" "" "" "87.1" "91.2" "86.9" "75.3" "109.6" "128.5" "89.3" "92.5" "105.7" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6663996802989080831" "False" "High" "IsMasterProtein" "Q15119" "[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial OS=Homo sapiens OX=9606 GN=PDK2 PE=1 SV=2" "0.000" "False" "11.579" "10" "4" "4" "3" "407" "46.1" "6.61" "15.58" "4" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus" "kinase activity;other molecular function" "Pf02518, Pf10436" "5164" "ENSG00000005882" "PDK2" "A8K3A7; B3KNW0; hsa:5164; Q15119; Q6P515; Q9BS05" "" "Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid" "2" "0" "1.132" "1.334" "0.962" "1.167" "1.157" "1.220" "1.199" "1.235" "1.044" "93.2" "105.6" "124.4" "89.7" "108.8" "107.9" "113.8" "111.8" "115.1" "97.4" "" "" "" "" "" "" "" "" "" "" "83.8" "85.4" "112.5" "87.6" "89.8" "107.9" "85.2" "98.8" "103.0" "34.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2381350149897154971" "False" "High" "IsMasterProtein" "P51572" "B-cell receptor-associated protein 31 OS=Homo sapiens OX=9606 GN=BCAP31 PE=1 SV=3" "0.000" "False" "11.572" "12" "3" "3" "3" "246" "28.0" "8.44" "11.68" "3" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05529, Pf18035" "10134" "ENSG00000185825" "BCAP31" "B3KQ79; D3DWV5; hsa:10134; P51572; Q13836; Q96CF0" "" "RSV-host interactions; RHOA GTPase cycle; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Apoptotic cleavage of cellular proteins" "5" "0" "1.017" "1.001" "0.993" "0.935" "1.049" "1.032" "1.086" "1.061" "0.888" "420.7" "427.8" "421.2" "417.7" "393.6" "441.5" "434.4" "456.8" "446.3" "373.5" "" "" "" "" "" "" "" "" "" "" "378.3" "346.2" "381.0" "407.7" "324.8" "441.5" "325.3" "403.5" "399.3" "133.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4477039985153313933" "False" "High" "IsMasterProtein" "O94952" "F-box only protein 21 OS=Homo sapiens OX=9606 GN=FBXO21 PE=1 SV=2" "0.000" "False" "11.562" "8" "3" "3" "3" "628" "72.2" "6.09" "10.99" "3" "protein metabolism;other metabolic processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf08755, Pf13369" "23014" "ENSG00000135108" "FBXO21" "B3KMF0; hsa:23014; O94952; Q5BJG0; Q9H087" "" "Neddylation; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.056" "0.978" "0.903" "1.028" "1.077" "1.143" "0.977" "1.086" "0.889" "146.2" "154.4" "142.9" "132.1" "150.3" "157.4" "167.1" "142.9" "158.8" "129.9" "" "" "" "" "" "" "" "" "" "" "131.4" "124.9" "129.3" "128.9" "124.0" "157.4" "125.2" "126.2" "142.1" "46.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043642977461230788" "False" "High" "IsMasterProtein" "Q92575" "UBX domain-containing protein 4 OS=Homo sapiens OX=9606 GN=UBXN4 PE=1 SV=2" "0.000" "False" "11.542" "10" "5" "5" "5" "508" "56.7" "6.38" "11.38" "5" "stress response" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf00789" "23190" "ENSG00000144224" "UBXN4" "A8K9W4; hsa:23190; Q4ZG56; Q8IYM5; Q92575" "" "" "0" "0" "1.111" "0.958" "0.902" "1.159" "1.016" "1.218" "1.207" "0.967" "0.936" "296.4" "329.3" "284.1" "267.3" "343.5" "301.1" "361.1" "357.8" "286.5" "277.5" "" "" "" "" "" "" "" "" "" "" "266.5" "266.5" "257.0" "261.0" "283.5" "301.1" "270.3" "316.0" "256.4" "99.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5142432278754861003" "False" "High" "IsMasterProtein" "Q5TEC6" "Histone H3-7 OS=Homo sapiens OX=9606 GN=H3-7 PE=1 SV=1" "0.000" "False" "11.539" "31" "5" "14" "2" "136" "15.4" "11.27" "44.99" "5" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00125" "" "ENSG00000273213" "H3-7" "Q5TEC6" "" "" "0" "0" "0.919" "0.856" "0.837" "0.951" "0.903" "0.888" "0.861" "0.798" "0.838" "427.3" "392.5" "365.8" "357.6" "406.5" "386.1" "379.4" "367.7" "341.1" "358.2" "" "" "" "" "" "" "" "" "" "" "384.2" "317.6" "330.9" "349.1" "335.5" "386.1" "284.1" "324.8" "305.2" "127.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3749115953426157303" "False" "High" "IsMasterProtein" "Q6PGN9" "Proline/serine-rich coiled-coil protein 1 OS=Homo sapiens OX=9606 GN=PSRC1 PE=1 SV=1" "0.000" "False" "11.515" "9" "3" "3" "3" "363" "38.8" "11.21" "11.67" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf15259" "84722" "ENSG00000134222" "PSRC1" "hsa:84722; Q5T2Z3; Q6PGN9; Q6ZTI8; Q71MG3; Q9BV77" "Aryl hydrocarbon receptor pathway" "" "1" "0" "0.921" "0.655" "1.060" "1.063" "0.733" "1.062" "0.943" "0.726" "0.840" "208.5" "192.0" "136.4" "221.0" "221.7" "152.9" "221.4" "196.6" "151.4" "175.1" "" "" "" "" "" "" "" "" "" "" "187.4" "155.3" "123.4" "215.7" "182.9" "152.9" "165.8" "173.7" "135.5" "62.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6434237713970420089" "False" "High" "IsMasterProtein" "Q9Y291" "Small ribosomal subunit protein mS33 OS=Homo sapiens OX=9606 GN=MRPS33 PE=1 SV=1" "0.000" "False" "11.506" "19" "2" "3" "2" "106" "12.6" "10.11" "11.00" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08293" "51650" "ENSG00000090263" "MRPS33" "hsa:51650; Q9Y291" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.835" "0.884" "0.959" "0.874" "0.818" "0.879" "0.779" "0.958" "1.184" "206.0" "172.0" "182.2" "197.5" "180.0" "168.4" "181.0" "160.5" "197.3" "243.8" "" "" "" "" "" "" "" "" "" "" "185.2" "139.2" "164.8" "192.8" "148.6" "168.4" "135.5" "141.8" "176.5" "87.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8778446884232701791" "False" "High" "IsMasterProtein" "Q9UK97" "F-box only protein 9 OS=Homo sapiens OX=9606 GN=FBXO9 PE=1 SV=1" "0.000" "False" "11.499" "6" "2" "3" "2" "447" "52.3" "6.15" "10.20" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00646, Pf19270" "26268" "ENSG00000112146" "FBXO9" "A6NFW3; B3KMM6; hsa:26268; O75986; Q59EH8; Q6PKH7; Q9NT57; Q9UK97; Q9Y593" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.153" "1.006" "0.933" "1.121" "1.130" "1.104" "1.041" "1.057" "0.960" "180.5" "208.1" "181.5" "168.3" "202.4" "204.0" "199.3" "187.8" "190.8" "173.4" "" "" "" "" "" "" "" "" "" "" "162.3" "168.4" "164.2" "164.3" "167.0" "204.0" "149.2" "165.9" "170.7" "61.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7714801153834532541" "False" "High" "IsMasterProtein" "O14733" "Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens OX=9606 GN=MAP2K7 PE=1 SV=2" "0.000" "False" "11.486" "8" "4" "4" "4" "419" "47.5" "9.16" "12.41" "4" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5609" "ENSG00000076984" "MAP2K7" "B2R9S5; D6W659; hsa:5609; O14648; O14733; O14816; O60452; O60453; Q1PG43; Q8IY10" "MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Alzheimer's disease and miRNA effects; Glioblastoma signaling pathways; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Photodynamic therapy-induced AP-1 survival signaling; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; MAPK cascade; Translation inhibitors in chronically activated PDGFRA cells; Hepatitis B infection; IL-18 signaling pathway; Insulin signaling; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Alzheimer's disease; GNAQ pathways in port-wine stain; ErbB signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated MAPK activation; Oxidative Stress Induced Senescence; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; Uptake and function of anthrax toxins" "28" "0" "1.026" "1.088" "1.012" "1.095" "1.088" "1.133" "1.135" "1.106" "1.296" "322.3" "330.8" "350.6" "326.3" "353.0" "350.7" "365.0" "365.7" "356.6" "417.7" "" "" "" "" "" "" "" "" "" "" "289.8" "267.7" "317.1" "318.5" "291.3" "350.7" "273.3" "323.0" "319.0" "149.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2632668230264232030" "False" "High" "IsMasterProtein" "P61024" "Cyclin-dependent kinases regulatory subunit 1 OS=Homo sapiens OX=9606 GN=CKS1B PE=1 SV=1" "0.000" "False" "11.471" "41" "4" "7" "3" "79" "9.7" "8.94" "18.90" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01111" "1163" "ENSG00000173207" "CKS1B" "hsa:1163; P33551; P61024" "Small cell lung cancer" "SCF(Skp2)-mediated degradation of p27/p21; Cyclin D associated events in G1" "3" "0" "0.850" "0.963" "0.856" "0.848" "1.026" "0.837" "0.960" "1.003" "0.891" "295.2" "251.0" "284.3" "252.8" "250.3" "302.9" "246.9" "283.2" "296.0" "262.9" "" "" "" "" "" "" "" "" "" "" "265.4" "203.1" "257.2" "246.7" "206.6" "302.9" "184.9" "250.2" "264.8" "93.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-228772176721817864" "False" "High" "IsMasterProtein" "Q96HY6" "DDRGK domain-containing protein 1 OS=Homo sapiens OX=9606 GN=DDRGK1 PE=1 SV=2" "0.000" "False" "11.471" "8" "2" "3" "2" "314" "35.6" "5.12" "13.39" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf09756" "65992" "ENSG00000198171" "DDRGK1" "A6NIU5; C9JSZ5; hsa:65992; Q96HY6; Q9BW47" "" "RHOA GTPase cycle" "1" "0" "1.169" "0.807" "0.951" "1.033" "1.302" "0.865" "0.812" "0.808" "1.237" "21.1" "24.7" "17.1" "20.1" "21.8" "27.5" "18.3" "17.2" "17.1" "26.1" "" "" "" "" "" "" "" "" "" "" "19.0" "20.0" "15.4" "19.6" "18.0" "27.5" "13.7" "15.2" "15.3" "9.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2129800861400375686" "False" "High" "IsMasterProtein" "O60220" "Mitochondrial import inner membrane translocase subunit Tim8 A OS=Homo sapiens OX=9606 GN=TIMM8A PE=1 SV=1" "0.000" "False" "11.455" "38" "3" "5" "3" "97" "11.0" "5.16" "16.33" "3" "cell organization and biogenesis;transport;developmental processes" "other membranes;mitochondrion" "other molecular function" "Pf02953" "1678" "ENSG00000126953" "TIMM8A" "B2R5A6; O60220; Q6IRW6" "" "Mitochondrial protein import" "1" "0" "0.984" "1.030" "0.895" "1.067" "1.008" "1.036" "0.938" "0.983" "0.931" "362.9" "357.2" "373.9" "324.9" "387.3" "365.9" "375.9" "340.4" "356.9" "338.0" "" "" "" "" "" "" "" "" "" "" "326.3" "289.0" "338.2" "317.2" "319.6" "365.9" "281.4" "300.7" "319.3" "120.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3736107449275984803" "False" "High" "IsMasterProtein" "Q96M96" "FYVE, RhoGEF and PH domain-containing protein 4 OS=Homo sapiens OX=9606 GN=FGD4 PE=1 SV=2" "0.000" "False" "11.446" "5" "4" "4" "4" "766" "86.6" "6.13" "11.76" "4" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00169, Pf00621, Pf01363" "121512" "ENSG00000139132" "FGD4" "hsa:121512; Q6ULS2; Q8TCP6; Q96M96" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Intracellular trafficking proteins involved in CMT neuropathy" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7426344905124172545" "False" "High" "IsMasterProtein" "Q9BR61" "Acyl-CoA-binding domain-containing protein 6 OS=Homo sapiens OX=9606 GN=ACBD6 PE=1 SV=1" "0.000" "False" "11.436" "14" "4" "4" "4" "282" "31.1" "5.11" "14.47" "4" "" "cytosol" "other molecular function" "Pf00887, Pf12796" "84320" "ENSG00000230124" "ACBD6" "hsa:84320; Q9BR61" "" "Mitochondrial Fatty Acid Beta-Oxidation" "1" "0" "0.992" "0.898" "1.022" "0.974" "0.926" "0.939" "1.072" "0.962" "1.974" "176.5" "175.0" "158.5" "180.4" "171.9" "163.4" "165.7" "189.2" "169.8" "348.3" "" "" "" "" "" "" "" "" "" "" "158.7" "141.6" "143.4" "176.1" "141.8" "163.4" "124.1" "167.1" "151.9" "124.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691749111498675631" "False" "High" "IsMasterProtein" "O14531" "Dihydropyrimidinase-related protein 4 OS=Homo sapiens OX=9606 GN=DPYSL4 PE=1 SV=2" "0.000" "False" "11.410" "3" "1" "5" "1" "572" "61.8" "7.09" "20.44" "1" "developmental processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf01979" "10570" "ENSG00000151640" "DPYSL4" "B2RMQ1; D3DRG5; hsa:10570; O00240; O14531; Q5T0Q7" "" "CRMPs in Sema3A signaling" "1" "0" "1.052" "1.018" "0.992" "1.056" "0.933" "1.081" "1.037" "0.981" "0.910" "514.8" "541.8" "524.2" "511.0" "543.9" "480.4" "556.5" "533.8" "505.0" "468.6" "" "" "" "" "" "" "" "" "" "" "462.9" "438.4" "474.2" "498.8" "448.8" "480.4" "416.7" "471.5" "451.8" "167.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-240902922766624585" "False" "High" "IsMasterProtein" "Q8N5D0" "WD and tetratricopeptide repeats protein 1 OS=Homo sapiens OX=9606 GN=WDTC1 PE=1 SV=2" "0.000" "False" "11.384" "5" "3" "3" "3" "677" "75.9" "7.27" "9.62" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400" "23038" "ENSG00000142784" "WDTC1" "D3DPL5; hsa:23038; Q5SSC5; Q8N5D0; Q9NV87; Q9UPW4" "" "Neddylation" "1" "0" "0.867" "0.968" "0.880" "0.880" "0.840" "0.824" "0.901" "0.859" "0.839" "241.1" "209.1" "233.4" "212.3" "212.2" "202.5" "198.7" "217.2" "207.2" "202.3" "" "" "" "" "" "" "" "" "" "" "216.8" "169.2" "211.1" "207.2" "175.1" "202.5" "148.8" "191.9" "185.4" "72.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "756136000491077603" "False" "High" "IsMasterProtein" "P08236" "Beta-glucuronidase OS=Homo sapiens OX=9606 GN=GUSB PE=1 SV=2" "0.000" "False" "11.357" "6" "5" "7" "5" "651" "74.7" "7.02" "15.25" "5" "protein metabolism;other metabolic processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00703, Pf02836, Pf02837" "2990" "ENSG00000169919" "GUSB" "B4E1F6; E9PCV0; hsa:2990; P08236; Q549U0; Q96CL9" "Glycosaminoglycan degradation" "Neutrophil degranulation; HS-GAG degradation; Hyaluronan uptake and degradation; MPS VII - Sly syndrome" "5" "0" "1.144" "1.185" "1.027" "1.115" "1.245" "1.142" "1.016" "1.125" "0.945" "177.9" "203.4" "210.7" "182.7" "198.4" "221.5" "203.1" "180.8" "200.1" "168.1" "" "" "" "" "" "" "" "" "" "" "159.9" "164.6" "190.6" "178.4" "163.7" "221.5" "152.1" "159.7" "179.0" "60.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3427861429656696180" "False" "High" "IsMasterProtein" "O95197" "Reticulon-3 OS=Homo sapiens OX=9606 GN=RTN3 PE=1 SV=2" "0.000" "False" "11.351" "4" "4" "4" "4" "1032" "112.5" "4.96" "9.28" "4" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf02453" "10313" "ENSG00000133318" "RTN3" "B3KQS2; B7Z308; B7Z4M0; F5H774; hsa:10313; O95197; Q147U9; Q496K2; Q53GN3; Q59EP0; Q5UEP2; Q6T930; Q7RTM7; Q7RTM8; Q7RTN3" "Alzheimer's disease and miRNA effects; Alzheimer's disease" "Synaptic adhesion-like molecules" "3" "0" "1.035" "1.039" "0.864" "0.983" "1.007" "0.965" "1.043" "0.918" "0.765" "358.2" "370.8" "372.1" "309.3" "352.2" "360.7" "345.6" "373.5" "328.8" "274.1" "" "" "" "" "" "" "" "" "" "" "322.1" "300.1" "336.5" "301.9" "290.7" "360.7" "258.8" "329.9" "294.2" "97.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3856989344168059657" "False" "High" "IsMasterProtein" "P04440" "HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens OX=9606 GN=HLA-DPB1 PE=1 SV=1" "0.000" "False" "11.341" "14" "3" "7" "2" "258" "29.1" "8.57" "24.46" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00969, Pf07654" "3115" "ENSG00000215048; ENSG00000223865; ENSG00000226826; ENSG00000230763; ENSG00000236693; ENSG00000237710" "HLA-DPB1" "A0PFJ7; A5I886; A8YPB3; B5U8B4; B7VF80; B7VF87; B8ZX68; B8ZYT0; B9W5S8; B9W6F7; B9W6F9; C0MPP5; C0MPQ2; C0MPQ3; C0MPQ5; C0MPQ6; C0MPQ7; C4R9J5; C5IZL1; hsa:3115; O00259; O19698; O19700; O19702; O19749; O46884; O77952; O98215; O98216; O98217; O98218; O98219; O98222; O98223; P01916; P04232; P04440; P13763; P79493; P79608; Q0P0L4; Q0ZFN3; Q14279; Q27S71; Q29682; Q29684; Q29698; Q29714; Q29775; Q29776; Q29778; Q29779; Q29781; Q29827; Q29828; Q29879; Q29880; Q29898; Q29977; Q2MGW3; Q30015; Q30031; Q30032; Q30033; Q30034; Q30050; Q30051; Q30052; Q30053; Q30054; Q30055; Q30174; Q4GY31; Q4JHD8; Q5ENE0; Q5ENE1; Q5ENW3; Q5EP46; Q5EP47; Q5EP49; Q5EP51; Q5EP52; Q5EP53; Q5EP56; Q5I4H8; Q5I4H9; Q5ISH4; Q5ISH5; Q5SQ73; Q5STP2; Q5YLA6; Q6IVX1; Q6LBX2; Q6LBX3; Q6LBX4; Q6LBX5; Q6LBX6; Q6LBX7; Q6PWX6; Q6TAS4; Q714U1; Q714U2; Q7YQ10; Q860Z7; Q8HWL7; Q8HWT5; Q8SNC4; Q95HC1; Q95IT7; Q95IT8; Q9BD13; Q9GIM2; Q9GIM4; Q9GIX6; Q9GJ41; Q9MY67; Q9TNT7; Q9TQE2; Q9XS11; Q9XS12" "Allograft rejection; Ebola virus infection in host" "MHC class II antigen presentation; Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; Interferon gamma signaling" "9" "0" "1.075" "0.979" "1.025" "1.047" "1.018" "1.185" "1.080" "1.086" "0.964" "242.4" "260.6" "237.4" "248.4" "253.7" "246.7" "287.1" "261.8" "263.2" "233.7" "" "" "" "" "" "" "" "" "" "" "217.9" "210.9" "214.7" "242.5" "209.4" "246.7" "215.0" "231.3" "235.5" "83.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8852376921802983428" "False" "High" "IsMasterProtein" "Q9UN19" "Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide OS=Homo sapiens OX=9606 GN=DAPP1 PE=1 SV=1" "0.000" "False" "11.340" "14" "3" "3" "3" "280" "32.2" "7.80" "11.79" "3" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf00017, Pf00169" "27071" "ENSG00000070190" "DAPP1" "hsa:27071; Q8TCK5; Q9UHF2; Q9UN19" "B cell receptor signaling pathway" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers" "2" "0" "1.117" "1.185" "0.964" "1.007" "1.063" "1.060" "0.997" "1.188" "1.612" "228.9" "255.7" "271.3" "220.6" "230.5" "243.3" "242.7" "228.2" "272.1" "368.9" "" "" "" "" "" "" "" "" "" "" "205.8" "206.9" "245.4" "215.4" "190.2" "243.3" "181.7" "201.6" "243.4" "131.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3081383647301722280" "False" "High" "IsMasterProtein" "Q16540" "Large ribosomal subunit protein uL23m OS=Homo sapiens OX=9606 GN=MRPL23 PE=1 SV=1" "0.000" "False" "11.333" "18" "2" "3" "2" "153" "17.8" "9.69" "11.54" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "nucleic acid binding activity;other molecular function" "Pf00276" "6150" "ENSG00000214026; ENSG00000288141" "MRPL23" "A8MT29; hsa:6150; Q16540; Q96Q71" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.925" "0.920" "0.869" "0.953" "0.961" "1.092" "0.971" "0.800" "1.053" "53.6" "49.6" "49.3" "46.6" "51.1" "51.5" "58.5" "52.1" "42.9" "56.5" "" "" "" "" "" "" "" "" "" "" "48.2" "40.1" "44.6" "45.5" "42.2" "51.5" "43.8" "46.0" "38.4" "20.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8524788288681439212" "False" "High" "IsMasterProtein" "O15164" "Transcription intermediary factor 1-alpha OS=Homo sapiens OX=9606 GN=TRIM24 PE=1 SV=3" "0.000" "False" "11.332" "5" "4" "4" "3" "1050" "116.8" "7.11" "11.47" "4" "cell cycle OR cell proliferation;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;kinase activity;other molecular function" "Pf00439, Pf00628, Pf00643" "8805" "ENSG00000122779" "TRIM24" "A4D1R7; A4D1R8; hsa:8805; O15164; O95854" "" "Signaling by BRAF and RAF1 fusions; Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "3" "0" "0.833" "1.055" "1.089" "1.170" "1.241" "0.846" "0.888" "1.365" "1.826" "15.6" "13.0" "16.4" "17.0" "18.2" "19.3" "13.2" "13.8" "21.3" "28.4" "" "" "" "" "" "" "" "" "" "" "14.0" "10.5" "14.9" "16.6" "15.0" "19.3" "9.9" "12.2" "19.0" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8819989402744158112" "False" "High" "IsMasterProtein" "Q96EW2" "HSPB1-associated protein 1 OS=Homo sapiens OX=9606 GN=HSPBAP1 PE=1 SV=1" "0.000" "False" "11.314" "7" "4" "4" "4" "488" "55.1" "5.60" "13.97" "4" "" "other cell component" "other molecular function" "Pf13621" "79663" "ENSG00000169087" "HSPBAP1" "hsa:79663; Q6P476; Q8N8J4; Q8NHH6; Q8WWF0; Q96EW2" "" "" "0" "0" "0.985" "1.001" "1.011" "1.025" "0.903" "1.000" "0.934" "1.019" "0.974" "231.9" "228.5" "232.3" "234.4" "237.6" "209.3" "231.9" "216.6" "236.3" "226.0" "" "" "" "" "" "" "" "" "" "" "208.5" "184.9" "210.1" "228.8" "196.1" "209.3" "173.7" "191.4" "211.5" "80.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "514101839783017752" "False" "High" "IsMasterProtein" "Q9P021" "Cysteine-rich PDZ-binding protein OS=Homo sapiens OX=9606 GN=CRIPT PE=1 SV=1" "0.000" "False" "11.310" "28" "2" "4" "2" "101" "11.2" "9.47" "16.21" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf10235" "9419" "ENSG00000119878" "CRIPT" "hsa:9419; Q9P021" "" "" "0" "0" "0.941" "0.905" "1.005" "0.997" "1.079" "0.903" "1.005" "1.037" "0.728" "334.8" "315.0" "303.0" "336.4" "333.8" "361.2" "302.4" "336.4" "347.3" "243.7" "" "" "" "" "" "" "" "" "" "" "301.0" "254.9" "274.1" "328.4" "275.5" "361.2" "226.4" "297.1" "310.7" "87.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7543040224215837261" "False" "High" "IsMasterProtein" "Q96EY4" "Translation machinery-associated protein 16 OS=Homo sapiens OX=9606 GN=TMA16 PE=1 SV=2" "0.000" "False" "11.305" "18" "4" "7" "4" "203" "23.8" "9.26" "18.62" "4" "other biological processes" "nucleus" "other molecular function" "Pf11176" "55319" "ENSG00000198498" "TMA16" "hsa:55319; Q0P6E4; Q0P6J1; Q96EY4; Q9NUR7" "" "" "0" "0" "0.961" "0.948" "0.895" "1.049" "1.118" "0.899" "0.972" "0.983" "2.809" "518.1" "497.9" "491.0" "463.9" "543.5" "579.4" "465.6" "503.5" "509.5" "1455.1" "" "" "" "" "" "" "" "" "" "" "465.8" "402.8" "444.1" "452.8" "448.5" "579.4" "348.7" "444.7" "455.9" "519.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444936349459715889" "False" "High" "IsMasterProtein" "Q32P28" "Prolyl 3-hydroxylase 1 OS=Homo sapiens OX=9606 GN=P3H1 PE=1 SV=2" "0.000" "False" "11.304" "5" "4" "4" "4" "736" "83.3" "5.14" "12.89" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf13640" "64175" "ENSG00000117385" "P3H1" "hsa:64175; Q32P28; Q7KZR4; Q96BR8; Q96SK8; Q96SL5; Q96SN3; Q9H6K3; Q9HC86; Q9HC87" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "0.986" "1.085" "0.975" "1.137" "1.104" "1.103" "1.031" "1.118" "1.484" "128.7" "126.9" "139.7" "125.5" "146.4" "142.1" "142.0" "132.7" "143.9" "190.9" "" "" "" "" "" "" "" "" "" "" "115.7" "102.6" "126.3" "122.5" "120.8" "142.1" "106.3" "117.2" "128.8" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5616367941086101468" "False" "High" "IsMasterProtein" "Q9NRW7" "Vacuolar protein sorting-associated protein 45 OS=Homo sapiens OX=9606 GN=VPS45 PE=1 SV=1" "0.000" "False" "11.286" "7" "4" "4" "4" "570" "65.0" "8.24" "15.09" "4" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf00995" "11311" "ENSG00000136631" "VPS45" "D3DUZ9; F5H8K1; hsa:11311; Q15715; Q53FR8; Q5T4P6; Q9NRW7; Q9Y4Z6" "" "Factors involved in megakaryocyte development and platelet production; Intra-Golgi traffic; SARS-CoV-2 modulates autophagy" "3" "0" "0.912" "0.936" "0.960" "1.086" "0.926" "0.944" "0.909" "0.900" "1.158" "229.8" "209.4" "215.1" "220.6" "249.5" "212.7" "216.9" "208.8" "206.9" "266.0" "" "" "" "" "" "" "" "" "" "" "206.6" "169.5" "194.6" "215.3" "205.9" "212.7" "162.4" "184.5" "185.1" "94.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4536078631798452952" "False" "High" "IsMasterProtein" "Q6P582" "Mitotic-spindle organizing protein 2A OS=Homo sapiens OX=9606 GN=MZT2A PE=1 SV=2" "0.000" "False" "11.281" "27" "3" "5" "1" "158" "16.2" "9.64" "21.43" "3" "" "cytosol;cytoskeleton;nucleus" "" "Pf12926" "653784" "ENSG00000173272" "MZT2A" "hsa:653784; Q3SWV8; Q6P582; Q8WVB2" "2q21.1 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7670404762929313903" "False" "High" "IsMasterProtein" "Q9BYW2" "Histone-lysine N-methyltransferase SETD2 OS=Homo sapiens OX=9606 GN=SETD2 PE=1 SV=3" "0.000" "False" "11.279" "1" "3" "3" "3" "2564" "287.4" "6.14" "10.26" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00856, Pf08236, Pf17907" "29072" "ENSG00000181555" "SETD2" "hsa:29072; O75397; O75405; Q17RW8; Q5BKS9; Q5QGN2; Q69YI5; Q6IN64; Q6ZN53; Q6ZS25; Q8N3R0; Q8TCN0; Q9BYW2; Q9C0D1; Q9H696; Q9NZW9" "Histone modifications; Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; Pleural mesothelioma" "PKMTs methylate histone lysines" "8" "0" "0.966" "1.015" "0.931" "0.997" "0.962" "1.025" "0.851" "0.858" "1.623" "174.0" "168.1" "176.7" "161.9" "173.4" "167.5" "178.4" "148.1" "149.3" "282.4" "" "" "" "" "" "" "" "" "" "" "156.5" "136.0" "159.8" "158.1" "143.1" "167.5" "133.6" "130.8" "133.6" "100.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "908398624639479548" "False" "High" "IsMasterProtein" "P62913" "Large ribosomal subunit protein uL5 OS=Homo sapiens OX=9606 GN=RPL11 PE=1 SV=2" "0.000" "False" "11.273" "25" "4" "5" "4" "178" "20.2" "9.60" "12.49" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00281, Pf00673" "6135" "ENSG00000142676" "RPL11" "hsa:6135; P25121; P39026; P62913; Q8TDH2; Q9Y674" "MET in type 1 papillary renal cell carcinoma; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.794" "0.954" "0.811" "0.932" "0.678" "0.753" "0.942" "0.782" "0.900" "46.5" "36.9" "44.4" "37.7" "43.3" "31.5" "35.0" "43.8" "36.4" "41.9" "" "" "" "" "" "" "" "" "" "" "41.8" "29.9" "40.1" "36.8" "35.8" "31.5" "26.2" "38.7" "32.6" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2592776449693665757" "False" "High" "IsMasterProtein" "O95455" "dTDP-D-glucose 4,6-dehydratase OS=Homo sapiens OX=9606 GN=TGDS PE=1 SV=1" "0.000" "False" "11.268" "10" "4" "4" "4" "350" "40.2" "6.60" "12.02" "4" "other metabolic processes" "" "other molecular function" "Pf16363" "23483" "ENSG00000088451" "TGDS" "hsa:23483; O95455; Q05DQ3; Q2TU31; Q5T3Z2; Q9H1T9" "" "" "0" "0" "0.970" "1.034" "1.153" "0.977" "1.018" "0.880" "0.992" "1.058" "0.681" "160.2" "155.4" "165.6" "184.7" "156.6" "163.1" "141.0" "158.9" "169.5" "109.1" "" "" "" "" "" "" "" "" "" "" "144.1" "125.8" "149.8" "180.3" "129.2" "163.1" "105.6" "140.4" "151.7" "38.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5308881138529098641" "False" "High" "IsMasterProtein" "Q9Y244" "Proteasome maturation protein OS=Homo sapiens OX=9606 GN=POMP PE=1 SV=1" "0.000" "False" "11.263" "17" "2" "8" "2" "141" "15.8" "5.11" "23.29" "2" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf05348" "51371" "ENSG00000132963" "POMP" "A5HKJ2; D6MXU3; hsa:51371; Q9HB69; Q9Y244" "" "" "0" "0" "0.938" "1.008" "0.960" "1.058" "1.037" "1.096" "1.114" "1.134" "0.815" "434.0" "407.3" "437.4" "416.5" "459.3" "450.1" "475.8" "483.6" "492.3" "353.8" "" "" "" "" "" "" "" "" "" "" "390.2" "329.6" "395.6" "406.6" "379.0" "450.1" "356.3" "427.1" "440.5" "126.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4612502200950371664" "False" "High" "IsMasterProtein" "Q86V21" "Acetoacetyl-CoA synthetase OS=Homo sapiens OX=9606 GN=AACS PE=1 SV=1" "0.000" "False" "11.262" "5" "3" "4" "3" "672" "75.1" "6.24" "10.56" "3" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00501, Pf16177" "65985" "ENSG00000081760" "AACS" "hsa:65985; Q49AB9; Q49AC3; Q658Q8; Q86V21; Q8IWD2; Q8NEW5; Q9BSJ9; Q9H829; Q9HA19" "" "Synthesis of Ketone Bodies" "1" "0" "0.949" "0.969" "0.723" "0.933" "1.009" "0.970" "0.883" "0.781" "4.893" "57.4" "54.5" "55.7" "41.5" "53.6" "58.0" "55.7" "50.7" "44.9" "281.1" "" "" "" "" "" "" "" "" "" "" "51.6" "44.1" "50.3" "40.5" "44.2" "58.0" "41.7" "44.8" "40.1" "100.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5853825877774435955" "False" "High" "IsMasterProtein" "Q96HQ2" "CDKN2AIP N-terminal-like protein OS=Homo sapiens OX=9606 GN=CDKN2AIPNL PE=1 SV=1" "0.000" "False" "11.261" "22" "2" "5" "2" "116" "13.2" "5.00" "17.78" "2" "" "" "" "Pf11952" "91368" "ENSG00000237190" "CDKN2AIPNL" "hsa:91368; Q8WVE3; Q96HQ2" "" "" "0" "0" "0.981" "0.913" "0.816" "1.074" "1.088" "1.084" "0.915" "1.172" "0.788" "211.6" "207.6" "193.1" "172.6" "227.3" "230.2" "229.3" "193.6" "247.9" "166.7" "" "" "" "" "" "" "" "" "" "" "190.2" "168.0" "174.7" "168.5" "187.6" "230.2" "171.7" "171.0" "221.8" "59.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4612354553252099721" "False" "High" "IsMasterProtein" "Q12981" "Vesicle transport protein SEC20 OS=Homo sapiens OX=9606 GN=BNIP1 PE=1 SV=3" "0.000" "False" "11.243" "16" "3" "3" "3" "228" "26.1" "8.95" "12.00" "3" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf03908" "662" "ENSG00000113734" "BNIP1" "D3DQM3; D3DQM4; D3DQM5; D3DQM6; hsa:662; O75622; O75623; O75624; Q12981; Q6K044; Q96FG4" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "0.933" "1.108" "1.000" "1.091" "1.038" "1.183" "1.068" "1.048" "0.973" "209.8" "195.8" "232.4" "209.9" "228.9" "217.7" "248.1" "224.0" "219.8" "204.2" "" "" "" "" "" "" "" "" "" "" "188.6" "158.4" "210.2" "204.9" "188.9" "217.7" "185.8" "197.9" "196.6" "72.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8554271472140898461" "False" "High" "IsMasterProtein" "Q8N584" "Tetratricopeptide repeat protein 39C OS=Homo sapiens OX=9606 GN=TTC39C PE=1 SV=2" "0.000" "False" "11.222" "5" "3" "3" "3" "583" "65.8" "6.99" "11.50" "3" "cell organization and biogenesis;developmental processes" "" "" "Pf10300" "125488" "ENSG00000168234" "TTC39C" "B7WP63; hsa:125488; J3QRR1; Q0VAJ2; Q8N284; Q8N584" "" "" "0" "0" "1.182" "1.024" "0.945" "1.085" "1.004" "0.948" "0.995" "1.010" "0.957" "174.4" "206.2" "178.6" "164.8" "189.2" "175.0" "165.4" "173.5" "176.2" "166.8" "" "" "" "" "" "" "" "" "" "" "156.8" "166.8" "161.6" "160.9" "156.1" "175.0" "123.8" "153.2" "157.6" "59.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7769023371860008745" "False" "High" "IsMasterProtein" "Q8N5I2" "Arrestin domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ARRDC1 PE=1 SV=1" "0.000" "False" "11.220" "8" "3" "3" "3" "433" "46.0" "7.02" "12.39" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf00339, Pf02752" "92714" "ENSG00000197070" "ARRDC1" "hsa:92714; Q8N5I2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1533138465656150959" "False" "High" "IsMasterProtein" "Q5VWQ0" "Lysine-specific demethylase 9 OS=Homo sapiens OX=9606 GN=RSBN1 PE=1 SV=2" "0.000" "False" "11.216" "5" "4" "4" "3" "802" "90.0" "8.60" "13.30" "4" "cell organization and biogenesis" "nucleus" "other molecular function" "" "54665" "ENSG00000081019" "RSBN1" "A8K937; hsa:54665; Q5VWQ0; Q6AI21; Q8TC33; Q9HA80; Q9NUP6" "" "" "0" "0" "1.047" "0.972" "0.923" "0.988" "1.097" "0.996" "0.974" "0.881" "0.889" "171.2" "179.3" "166.4" "158.0" "169.2" "187.8" "170.6" "166.8" "150.9" "152.3" "" "" "" "" "" "" "" "" "" "" "153.9" "145.1" "150.6" "154.3" "139.6" "187.8" "127.7" "147.4" "135.0" "54.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1991199370327280785" "False" "High" "IsMasterProtein" "Q9HD26" "Golgi-associated PDZ and coiled-coil motif-containing protein OS=Homo sapiens OX=9606 GN=GOPC PE=1 SV=1" "0.000" "False" "11.205" "8" "3" "3" "3" "462" "50.5" "5.92" "12.64" "3" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595" "57120" "ENSG00000047932" "GOPC" "A6NM30; hsa:57120; Q59FS4; Q969U8; Q9HD26" "" "RHOQ GTPase cycle; RHO GTPases regulate CFTR trafficking" "2" "0" "1.103" "1.156" "1.122" "1.178" "1.193" "1.110" "1.175" "1.184" "5.923" "296.5" "326.9" "342.9" "332.6" "349.3" "353.7" "329.1" "348.3" "351.1" "1756.4" "" "" "" "" "" "" "" "" "" "" "266.6" "264.5" "310.2" "324.6" "288.2" "353.7" "246.4" "307.6" "314.2" "627.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1094871198918048732" "False" "High" "IsMasterProtein" "O00287" "Regulatory factor X-associated protein OS=Homo sapiens OX=9606 GN=RFXAP PE=1 SV=1" "0.000" "False" "11.203" "15" "3" "3" "3" "272" "28.2" "5.54" "11.19" "3" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf15289" "5994" "ENSG00000133111" "RFXAP" "B2R9T8; hsa:5994; O00287; Q5VZM6; Q8TC40" "" "" "0" "0" "0.886" "1.016" "0.964" "1.092" "0.965" "0.976" "1.068" "0.990" "0.872" "93.3" "82.7" "94.9" "90.0" "101.9" "90.1" "91.1" "99.7" "92.4" "81.4" "" "" "" "" "" "" "" "" "" "" "83.9" "67.0" "85.8" "87.9" "84.1" "90.1" "68.2" "88.0" "82.7" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-255680334974208161" "False" "High" "IsMasterProtein" "Q9Y4K4" "Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens OX=9606 GN=MAP4K5 PE=1 SV=3" "0.000" "False" "11.174" "2" "3" "3" "3" "846" "95.0" "7.72" "14.06" "3" "other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol" "kinase activity;other molecular function" "Pf00069, Pf00780" "11183" "ENSG00000012983" "MAP4K5" "A0A804HIS2; hsa:11183" "Angiopoietin-like protein 8 regulatory pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Insulin signaling" "" "3" "0" "1.029" "0.962" "0.920" "0.990" "0.933" "0.906" "0.906" "0.998" "0.864" "135.3" "139.2" "130.1" "124.4" "133.9" "126.2" "122.6" "122.6" "135.0" "116.9" "" "" "" "" "" "" "" "" "" "" "121.6" "112.6" "117.7" "121.4" "110.5" "126.2" "91.8" "108.2" "120.8" "41.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2262786275028472849" "False" "High" "IsMasterProtein" "Q9Y421" "Protein FAM32A OS=Homo sapiens OX=9606 GN=FAM32A PE=1 SV=2" "0.000" "False" "11.168" "28" "3" "3" "3" "112" "13.2" "9.99" "12.78" "3" "cell cycle OR cell proliferation;other biological processes" "nucleus" "" "Pf08555" "26017" "ENSG00000105058" "FAM32A" "hsa:26017; Q9BT02; Q9Y421" "" "mRNA Splicing - Major Pathway" "1" "0" "0.874" "0.941" "0.877" "0.949" "1.059" "0.904" "1.029" "0.893" "0.726" "408.2" "356.9" "384.2" "357.8" "387.4" "432.2" "369.0" "419.9" "364.6" "296.4" "" "" "" "" "" "" "" "" "" "" "367.0" "288.8" "347.6" "349.3" "319.7" "432.2" "276.3" "370.9" "326.3" "105.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298785526974998210" "False" "High" "IsMasterProtein" "Q9BTU6" "Phosphatidylinositol 4-kinase type 2-alpha OS=Homo sapiens OX=9606 GN=PI4K2A PE=1 SV=1" "0.000" "False" "11.151" "8" "4" "6" "4" "479" "54.0" "8.29" "17.46" "4" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "kinase activity;other molecular function" "Pf00454" "55361" "ENSG00000155252" "PI4K2A" "D3DR59; hsa:55361; Q9BTU6; Q9NSG8" "Thymic stromal lymphopoietin (TSLP) signaling pathway; Wnt signaling pathway" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane" "5" "0" "1.024" "1.003" "0.921" "0.947" "0.923" "0.916" "1.017" "0.998" "0.922" "419.1" "429.0" "420.2" "386.1" "397.0" "386.9" "384.0" "426.1" "418.2" "386.4" "" "" "" "" "" "" "" "" "" "" "376.8" "347.1" "380.1" "376.9" "327.6" "386.9" "287.5" "376.3" "374.2" "137.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2648921608470054018" "False" "High" "IsMasterProtein" "Q96L92" "Sorting nexin-27 OS=Homo sapiens OX=9606 GN=SNX27 PE=1 SV=2" "0.000" "False" "11.148" "6" "3" "4" "3" "541" "61.2" "6.49" "14.51" "3" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00595, Pf00787, Pf00788" "81609" "ENSG00000143376" "SNX27" "hsa:81609; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q96L92; Q9H3K8" "" "" "0" "0" "1.009" "1.050" "0.995" "1.044" "1.080" "1.081" "1.007" "1.130" "3.165" "335.1" "338.0" "351.9" "333.4" "349.8" "361.9" "362.3" "337.4" "378.7" "1060.5" "" "" "" "" "" "" "" "" "" "" "301.2" "273.5" "318.3" "325.4" "288.7" "361.9" "271.3" "298.0" "338.9" "378.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7515824926889841061" "False" "High" "IsMasterProtein" "Q8TDM0" "Breast carcinoma-amplified sequence 4 OS=Homo sapiens OX=9606 GN=BCAS4 PE=1 SV=1" "0.000" "False" "11.140" "16" "3" "3" "3" "211" "22.7" "5.86" "10.85" "3" "" "other cell component" "" "" "55653" "ENSG00000124243" "BCAS4" "hsa:55653; Q5TD52; Q5TD53; Q5TD54; Q5U5K7; Q5XKE8; Q8IXI7; Q8NEZ6; Q8TDL9; Q8TDM0; Q9NX13; Q9Y511" "" "" "0" "0" "0.971" "0.979" "0.945" "0.901" "0.987" "1.104" "0.973" "0.924" "0.941" "87.8" "85.3" "85.9" "83.0" "79.1" "86.7" "97.0" "85.5" "81.2" "82.6" "" "" "" "" "" "" "" "" "" "" "79.0" "69.0" "77.7" "81.0" "65.3" "86.7" "72.6" "75.5" "72.6" "29.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3548704678811192106" "False" "High" "IsMasterProtein" "Q8ND30" "Liprin-beta-2 OS=Homo sapiens OX=9606 GN=PPFIBP2 PE=1 SV=3" "0.000" "False" "11.128" "5" "4" "4" "4" "876" "98.5" "6.27" "12.99" "4" "cell organization and biogenesis" "cytosol;other cell component" "other molecular function" "Pf00536, Pf07647" "8495" "ENSG00000166387" "PPFIBP2" "B7Z433; E9PK77; hsa:8495; O75337; Q8ND30; Q8WW26" "Ectoderm differentiation" "Receptor-type tyrosine-protein phosphatases" "2" "0" "1.141" "0.868" "0.932" "0.991" "1.069" "1.023" "0.949" "0.898" "0.965" "222.7" "254.0" "193.2" "207.5" "220.7" "238.0" "227.8" "211.3" "200.0" "215.0" "" "" "" "" "" "" "" "" "" "" "200.2" "205.6" "174.8" "202.5" "182.1" "238.0" "170.6" "186.6" "179.0" "76.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4577230366185343110" "False" "High" "IsMasterProtein" "Q96GM8" "Target of EGR1 protein 1 OS=Homo sapiens OX=9606 GN=TOE1 PE=1 SV=1" "0.000" "False" "11.109" "9" "4" "4" "4" "510" "56.5" "7.18" "13.37" "4" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04857" "114034" "ENSG00000132773" "TOE1" "B4DEM6; hsa:114034; Q6IA35; Q8IWN5; Q96GM8; Q9H846" "" "" "0" "0" "1.036" "1.035" "0.908" "1.042" "1.039" "1.063" "1.076" "0.993" "1.126" "130.1" "134.8" "134.6" "118.1" "135.5" "135.2" "138.3" "140.0" "129.2" "146.5" "" "" "" "" "" "" "" "" "" "" "117.0" "109.1" "121.8" "115.3" "111.9" "135.2" "103.5" "123.7" "115.6" "52.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366050407919946154" "False" "High" "IsMasterProtein" "Q96II8" "DISP complex protein LRCH3 OS=Homo sapiens OX=9606 GN=LRCH3 PE=1 SV=2" "0.000" "False" "11.105" "5" "3" "3" "3" "777" "86.0" "6.71" "10.81" "3" "cell organization and biogenesis" "cytosol;other cell component" "" "Pf00307, Pf13855" "84859" "ENSG00000186001" "LRCH3" "B4E0T7; hsa:84859; Q96FP9; Q96II8; Q9NT52" "" "" "0" "0" "0.817" "1.006" "0.990" "1.146" "1.067" "1.087" "1.241" "0.971" "1.200" "26.0" "21.3" "26.2" "25.8" "29.9" "27.8" "28.3" "32.3" "25.3" "31.3" "" "" "" "" "" "" "" "" "" "" "23.4" "17.2" "23.7" "25.2" "24.6" "27.8" "21.2" "28.5" "22.6" "11.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3981569091438122921" "False" "High" "IsMasterProtein" "Q8N4P3" "Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 OS=Homo sapiens OX=9606 GN=HDDC3 PE=1 SV=3" "0.000" "False" "11.105" "21" "3" "4" "3" "179" "20.3" "6.74" "14.22" "3" "" "" "other molecular function" "Pf13328" "374659" "ENSG00000184508" "HDDC3" "hsa:374659; Q8N4P3" "" "" "0" "0" "0.956" "0.885" "0.939" "1.052" "0.929" "0.962" "1.008" "0.935" "0.920" "299.8" "286.7" "265.2" "281.5" "315.3" "278.4" "288.5" "302.3" "280.3" "275.7" "" "" "" "" "" "" "" "" "" "" "269.5" "232.0" "239.9" "274.8" "260.2" "278.4" "216.0" "267.0" "250.9" "98.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-390863097898701106" "False" "High" "IsMasterProtein" "Q14657" "EKC/KEOPS complex subunit LAGE3 OS=Homo sapiens OX=9606 GN=LAGE3 PE=1 SV=2" "0.000" "False" "11.089" "21" "2" "4" "2" "143" "14.8" "8.63" "23.21" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "" "Pf09341" "8270" "ENSG00000196976" "LAGE3" "hsa:8270; Q14657; Q5HY39; Q8IZ78" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.208" "1.149" "1.015" "1.146" "1.188" "1.061" "1.216" "1.281" "0.924" "144.3" "174.3" "165.8" "146.5" "165.3" "171.5" "153.2" "175.5" "184.9" "133.3" "" "" "" "" "" "" "" "" "" "" "129.8" "141.0" "150.0" "143.0" "136.4" "171.5" "114.7" "155.1" "165.4" "47.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779198879907914861" "False" "High" "IsMasterProtein" "P62328" "Thymosin beta-4 OS=Homo sapiens OX=9606 GN=TMSB4X PE=1 SV=2" "0.000" "False" "11.083" "45" "3" "24" "1" "44" "5.1" "5.06" "74.07" "3" "cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf01290" "7114" "ENSG00000205542" "TMSB4X" "hsa:7114; P01253; P01254; P62328; Q546P5; Q63576; Q9UE55" "Genes targeted by miRNAs in adipocytes; VEGFA-VEGFR2 signaling; IL-18 signaling pathway; Regulation of actin cytoskeleton" "Platelet degranulation" "5" "0" "0.884" "0.499" "0.842" "0.725" "0.731" "0.797" "0.868" "0.474" "0.425" "349.0" "308.4" "174.1" "294.0" "253.0" "254.9" "278.0" "302.9" "165.3" "148.3" "" "" "" "" "" "" "" "" "" "" "313.8" "249.5" "157.5" "287.0" "208.8" "254.9" "208.2" "267.5" "147.9" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9221829543246918026" "False" "High" "IsMasterProtein" "P23763" "Vesicle-associated membrane protein 1 OS=Homo sapiens OX=9606 GN=VAMP1 PE=1 SV=1" "0.000" "False" "11.081" "19" "2" "3" "1" "118" "12.9" "6.65" "15.25" "2" "cell organization and biogenesis;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00957" "6843" "ENSG00000139190" "VAMP1" "A8MVP3; D3DUR3; hsa:6843; O75468; P23763; Q15857; Q6FG94; Q8IVC9" "" "Toxicity of botulinum toxin type D (botD); Toxicity of botulinum toxin type G (botG); Toxicity of botulinum toxin type F (botF)" "3" "0" "1.111" "1.179" "0.934" "1.169" "1.319" "1.115" "0.988" "1.284" "0.927" "81.7" "90.8" "96.3" "76.3" "95.5" "107.7" "91.1" "80.7" "104.9" "75.7" "" "" "" "" "" "" "" "" "" "" "73.4" "73.4" "87.1" "74.5" "78.8" "107.7" "68.2" "71.3" "93.8" "27.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758038755542979545" "False" "High" "IsMasterProtein" "P61769" "Beta-2-microglobulin OS=Homo sapiens OX=9606 GN=B2M PE=1 SV=1" "0.000" "False" "11.054" "17" "2" "3" "2" "119" "13.7" "6.52" "12.34" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf07654" "567" "ENSG00000166710; ENSG00000273686" "B2M" "hsa:567; P01884; P61769; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4" "IL-18 signaling pathway" "ER-Phagosome pathway; Neutrophil degranulation; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Amyloid fiber formation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; DAP12 signaling; Interferon gamma signaling; Antigen Presentation: Folding, assembly and peptide loading of class I MHC; Modulation by Mtb of host immune system; Nef mediated downregulation of MHC class I complex cell surface expression; Endosomal/Vacuolar pathway" "13" "0" "0.908" "1.032" "1.038" "1.197" "1.186" "1.202" "1.078" "1.240" "0.700" "249.7" "226.7" "257.8" "259.1" "298.9" "296.3" "300.0" "269.3" "309.7" "174.9" "" "" "" "" "" "" "" "" "" "" "224.5" "183.4" "233.2" "253.0" "246.7" "296.3" "224.6" "237.9" "277.2" "62.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1854771477011875853" "False" "High" "IsMasterProtein" "Q14119" "Vascular endothelial zinc finger 1 OS=Homo sapiens OX=9606 GN=VEZF1 PE=1 SV=2" "0.000" "False" "11.029" "6" "3" "6" "1" "521" "56.9" "9.52" "13.48" "3" "stress response;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "7716" "ENSG00000136451" "VEZF1" "hsa:7716; Q14119" "" "" "0" "0" "1.419" "0.892" "1.139" "1.169" "1.296" "1.375" "1.432" "1.318" "1.161" "11.4" "16.2" "10.2" "13.0" "13.3" "14.8" "15.7" "16.3" "15.0" "13.2" "" "" "" "" "" "" "" "" "" "" "10.2" "13.1" "9.2" "12.7" "11.0" "14.8" "11.7" "14.4" "13.4" "4.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1734934898581359440" "False" "High" "IsMasterProtein" "P61457" "Pterin-4-alpha-carbinolamine dehydratase OS=Homo sapiens OX=9606 GN=PCBD1 PE=1 SV=2" "0.000" "False" "11.023" "39" "4" "5" "3" "104" "12.0" "6.80" "15.58" "4" "other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf01329" "5092" "ENSG00000166228" "PCBD1" "hsa:5092; P61457; P70519; P80095; Q9D930" "" "Phenylalanine metabolism" "1" "0" "0.861" "0.961" "0.866" "1.052" "0.958" "0.914" "0.961" "0.961" "0.769" "210.6" "181.3" "202.4" "182.5" "221.6" "201.7" "192.5" "202.3" "202.3" "161.9" "" "" "" "" "" "" "" "" "" "" "189.3" "146.7" "183.1" "178.1" "182.9" "201.7" "144.2" "178.7" "181.0" "57.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5723466212240730486" "False" "High" "IsMasterProtein" "Q13574" "Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4" "0.000" "False" "11.005" "5" "3" "3" "3" "928" "103.9" "8.05" "12.40" "3" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00023, Pf00130, Pf00609, Pf00781" "8525" "ENSG00000149091" "DGKZ" "B7Z2M9; B7Z6M3; E9PPW4; F6UCU9; G3V0F6; hsa:8525; J3KNJ6; O00542; Q13574; Q6ZVG7; Q8IVW9" "Myometrial relaxation and contraction pathways; Leptin-insulin signaling overlap; Glycerolipids and glycerophospholipids; Modulators of TCR signaling and T cell activation" "Effects of PIP2 hydrolysis" "5" "0" "1.009" "0.830" "0.908" "1.133" "1.025" "1.059" "0.963" "0.866" "0.925" "86.5" "87.3" "71.9" "78.6" "98.1" "88.7" "91.7" "83.4" "75.0" "80.1" "" "" "" "" "" "" "" "" "" "" "77.8" "70.7" "65.0" "76.8" "81.0" "88.7" "68.6" "73.6" "67.1" "28.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-212858070142576811" "False" "High" "IsMasterProtein" "Q86VX2" "COMM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=COMMD7 PE=1 SV=2" "0.000" "False" "10.986" "17" "3" "3" "3" "200" "22.5" "5.92" "13.91" "3" "signal transduction;other biological processes" "other cell component" "other molecular function" "Pf07258, Pf21672" "149951" "ENSG00000149600" "COMMD7" "A2BHJ2; B3KTZ2; hsa:149951; Q5JYB0; Q86VX2; Q96SI7; Q9BW53" "" "Neddylation" "1" "0" "0.998" "0.971" "0.891" "1.061" "0.961" "1.027" "1.051" "1.061" "1.051" "336.4" "335.7" "326.5" "299.7" "356.8" "323.4" "345.4" "353.6" "356.8" "353.6" "" "" "" "" "" "" "" "" "" "" "302.5" "271.7" "295.3" "292.6" "294.4" "323.4" "258.7" "312.3" "319.3" "126.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6717347442497409014" "False" "High" "IsMasterProtein" "Q9NXF7" "DDB1- and CUL4-associated factor 16 OS=Homo sapiens OX=9606 GN=DCAF16 PE=1 SV=1" "0.000" "False" "10.973" "11" "2" "3" "2" "216" "24.2" "6.04" "11.80" "2" "protein metabolism;other metabolic processes" "nucleus;other cell component" "" "Pf15349" "54876" "ENSG00000163257" "DCAF16" "B3KPB7; hsa:54876; Q9NXF7" "" "Neddylation" "1" "0" "0.950" "1.007" "1.014" "0.882" "0.969" "0.965" "1.003" "1.028" "1.090" "288.5" "274.2" "290.4" "292.6" "254.4" "279.7" "278.3" "289.3" "296.4" "314.3" "" "" "" "" "" "" "" "" "" "" "259.4" "221.9" "262.7" "285.7" "209.9" "279.7" "208.4" "255.5" "265.2" "112.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8718116979404921777" "False" "High" "IsMasterProtein" "P51116" "RNA-binding protein FXR2 OS=Homo sapiens OX=9606 GN=FXR2 PE=1 SV=2" "0.000" "False" "10.955" "7" "4" "4" "2" "673" "74.2" "6.23" "13.16" "4" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf05641, Pf12235, Pf16096, Pf17904, Pf18336" "9513" "ENSG00000129245" "FXR2" "B2R9M2; D3DTQ1; hsa:9513; P51116; Q86V09; Q8WUM2" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.036" "1.182" "0.859" "0.995" "1.000" "1.105" "0.979" "0.879" "1.279" "106.6" "110.4" "126.0" "91.5" "106.1" "106.6" "117.8" "104.4" "93.7" "136.3" "" "" "" "" "" "" "" "" "" "" "95.8" "89.4" "114.0" "89.4" "87.5" "106.6" "88.2" "92.2" "83.9" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699883784093853229" "False" "High" "IsMasterProtein" "Q8IY47" "Kelch repeat and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KBTBD2 PE=1 SV=2" "0.000" "False" "10.954" "6" "4" "5" "4" "623" "71.3" "5.62" "13.92" "4" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "25948" "ENSG00000170852" "KBTBD2" "A8K9T7; hsa:25948; Q86Y62; Q8IY47; Q9P239; Q9UFM7; Q9Y382" "" "" "0" "0" "1.019" "1.014" "0.935" "1.085" "0.939" "1.018" "0.954" "0.974" "0.959" "513.7" "523.6" "521.1" "480.3" "557.2" "482.6" "522.9" "490.2" "500.3" "492.7" "" "" "" "" "" "" "" "" "" "" "461.9" "423.7" "471.3" "468.8" "459.8" "482.6" "391.6" "433.0" "447.6" "175.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1355905293603533123" "False" "High" "IsMasterProtein" "Q9Y2Z2" "Protein MTO1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MTO1 PE=1 SV=2" "0.000" "False" "10.941" "5" "4" "4" "4" "717" "79.9" "8.31" "13.56" "4" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf01134, Pf13932, Pf21680" "25821" "ENSG00000135297" "MTO1" "B3KQB5; hsa:25821; Q5SWL2; Q5SWL3; Q5SWL4; Q8NDN7; Q8WZ57; Q96FE6; Q9BS06; Q9Y2Z2" "" "tRNA modification in the mitochondrion" "1" "0" "0.979" "1.023" "0.916" "1.059" "0.966" "0.975" "0.908" "0.927" "1.063" "314.8" "308.3" "322.1" "288.3" "333.4" "304.2" "306.8" "285.9" "291.8" "334.5" "" "" "" "" "" "" "" "" "" "" "283.0" "249.4" "291.4" "281.4" "275.1" "304.2" "229.8" "252.5" "261.1" "119.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8937681193743142864" "False" "High" "IsMasterProtein" "Q9P1F3" "Costars family protein ABRACL OS=Homo sapiens OX=9606 GN=ABRACL PE=1 SV=1" "0.000" "False" "10.934" "60" "3" "4" "3" "81" "9.1" "6.29" "12.24" "3" "other biological processes" "" "" "Pf14705" "58527" "ENSG00000146386" "ABRACL" "hsa:58527; Q5SZC8; Q9P0A1; Q9P1F3" "" "" "0" "0" "1.168" "1.255" "1.687" "0.805" "1.305" "1.300" "1.602" "1.077" "1.042" "104.1" "121.6" "130.7" "175.7" "83.8" "135.9" "135.3" "166.8" "112.1" "108.5" "" "" "" "" "" "" "" "" "" "" "93.6" "98.4" "118.2" "171.5" "69.1" "135.9" "101.3" "147.3" "100.3" "38.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4517767279852886881" "False" "High" "IsMasterProtein" "Q16143" "Beta-synuclein OS=Homo sapiens OX=9606 GN=SNCB PE=1 SV=1" "0.000" "False" "10.931" "23" "3" "3" "3" "134" "14.3" "4.41" "9.79" "3" "cell-cell signaling;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf01387" "6620" "ENSG00000074317" "SNCB" "hsa:6620; Q16143; Q6IAX7" "5q35 copy number variation" "MTF1 activates gene expression" "2" "0" "0.981" "1.090" "0.894" "0.948" "1.136" "1.153" "1.148" "1.004" "0.772" "103.8" "101.8" "113.2" "92.8" "98.4" "117.9" "119.6" "119.2" "104.2" "80.1" "" "" "" "" "" "" "" "" "" "" "93.3" "82.4" "102.4" "90.6" "81.2" "117.9" "89.6" "105.3" "93.3" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3640417393520932039" "False" "High" "IsMasterProtein" "Q9P031" "Thyroid transcription factor 1-associated protein 26 OS=Homo sapiens OX=9606 GN=CCDC59 PE=1 SV=2" "0.000" "False" "10.930" "17" "4" "4" "4" "241" "28.7" "9.88" "11.92" "4" "" "nucleus" "" "Pf08524" "29080" "ENSG00000133773" "CCDC59" "hsa:29080; Q9H2V5; Q9NW62; Q9P031" "" "Surfactant metabolism" "1" "0" "0.877" "0.890" "0.849" "0.902" "0.823" "0.851" "0.918" "0.800" "0.928" "518.8" "455.1" "461.9" "440.5" "468.2" "427.1" "441.7" "476.1" "414.8" "481.3" "" "" "" "" "" "" "" "" "" "" "466.5" "368.2" "417.8" "429.9" "386.4" "427.1" "330.8" "420.6" "371.2" "171.8" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2514407203909916173" "False" "High" "IsMasterProtein" "O95363" "Phenylalanine--tRNA ligase, mitochondrial OS=Homo sapiens OX=9606 GN=FARS2 PE=1 SV=1" "0.000" "False" "10.929" "8" "4" "4" "4" "451" "52.3" "7.46" "11.59" "4" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf01409, Pf03147" "10667" "ENSG00000145982" "FARS2" "B2R664; hsa:10667; O95363; Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.103" "1.068" "0.930" "1.104" "1.114" "1.044" "1.125" "1.131" "1.463" "375.6" "414.3" "401.3" "349.4" "414.6" "418.6" "392.3" "422.8" "424.7" "549.6" "" "" "" "" "" "" "" "" "" "" "337.7" "335.2" "363.0" "341.1" "342.1" "418.6" "293.8" "373.4" "380.1" "196.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "587629030482776779" "False" "High" "IsMasterProtein" "Q5VZM2" "Ras-related GTP-binding protein B OS=Homo sapiens OX=9606 GN=RRAGB PE=1 SV=1" "0.000" "False" "10.928" "7" "3" "4" "3" "374" "43.2" "6.21" "11.49" "3" "stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04670" "10325" "ENSG00000083750" "RRAGB" "A8K042; hsa:10325; Q15348; Q5VZM2; Q8N3T0" "Target of rapamycin signaling; 2q37 copy number variation syndrome" "TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling" "9" "0" "1.086" "1.011" "0.944" "1.179" "1.071" "1.107" "1.047" "1.119" "0.848" "428.4" "465.5" "433.1" "404.4" "505.2" "459.0" "474.4" "448.4" "479.5" "363.1" "" "" "" "" "" "" "" "" "" "" "385.2" "376.6" "391.8" "394.7" "416.9" "459.0" "355.2" "396.0" "429.0" "129.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2540636687362609874" "False" "High" "IsMasterProtein" "O94768" "Serine/threonine-protein kinase 17B OS=Homo sapiens OX=9606 GN=STK17B PE=1 SV=1" "0.000" "False" "10.927" "10" "3" "5" "3" "372" "42.3" "5.25" "11.43" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9262" "ENSG00000081320" "STK17B" "hsa:9262; O94768" "" "" "0" "0" "1.029" "0.907" "0.871" "1.013" "0.886" "0.980" "0.898" "1.093" "1.575" "119.3" "122.8" "108.2" "103.9" "120.8" "105.7" "116.9" "107.1" "130.4" "187.9" "" "" "" "" "" "" "" "" "" "" "107.3" "99.3" "97.9" "101.4" "99.7" "105.7" "87.5" "94.6" "116.6" "67.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1337195466672693139" "False" "High" "IsMasterProtein" "Q9BZX2" "Uridine-cytidine kinase 2 OS=Homo sapiens OX=9606 GN=UCK2 PE=1 SV=1" "0.000" "False" "10.927" "12" "3" "3" "2" "261" "29.3" "6.70" "11.34" "3" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "7371" "ENSG00000143179" "UCK2" "hsa:7371; Q5VV91; Q7KZV3; Q92528; Q96KG5; Q9BU42; Q9BZX2" "Fluoropyrimidine activity; Pyrimidine metabolism" "Pyrimidine salvage" "3" "1" "1.112" "1.054" "0.948" "1.126" "1.098" "1.000" "1.033" "1.210" "1.017" "313.4" "348.4" "330.4" "297.1" "352.8" "344.2" "313.5" "323.6" "379.2" "318.7" "" "" "" "" "" "" "" "" "" "" "281.8" "281.9" "298.8" "290.0" "291.1" "344.2" "234.7" "285.9" "339.3" "113.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2107690767117566608" "False" "High" "IsMasterProtein" "P04150" "Glucocorticoid receptor OS=Homo sapiens OX=9606 GN=NR3C1 PE=1 SV=1" "0.000" "False" "10.918" "5" "4" "5" "4" "777" "85.6" "6.38" "13.26" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf02155" "2908" "ENSG00000113580" "NR3C1" "A0ZXF9; B0LPG8; D3DQF4; F5ATB7; hsa:2908; P04150; P04151; Q53EP5; Q6N0A4" "Nuclear receptors; Adipogenesis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Endoderm differentiation; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Transcription factor regulation in adipogenesis; White fat cell differentiation; Vitamin D in inflammatory diseases; 16p11.2 proximal deletion syndrome; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways; Serotonin receptor 4/6/7 and NR3C signaling" "Potential therapeutics for SARS; Regulation of RUNX2 expression and activity; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand; FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Circadian Clock; SUMOylation of intracellular receptors; PTK6 Expression; Regulation of NPAS4 gene transcription" "21" "0" "0.942" "0.859" "0.919" "1.024" "0.928" "1.098" "0.917" "0.930" "1.265" "372.8" "351.2" "320.3" "342.5" "381.7" "345.8" "409.4" "342.0" "346.7" "471.5" "" "" "" "" "" "" "" "" "" "" "335.2" "284.2" "289.7" "334.3" "315.0" "345.8" "306.5" "302.1" "310.2" "168.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6591516084365101626" "False" "High" "IsMasterProtein" "Q9H5X1" "Cytosolic iron-sulfur assembly component 2A OS=Homo sapiens OX=9606 GN=CIAO2A PE=1 SV=1" "0.000" "False" "10.917" "13" "2" "3" "2" "160" "18.3" "4.88" "10.21" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01883" "84191" "ENSG00000166797" "CIAO2A" "A6NKS1; B2R5F8; B7Z8Z5; hsa:84191; Q9H5X1" "2q11.2 copy number variation syndrome" "" "1" "0" "0.922" "0.959" "0.931" "1.042" "0.995" "1.012" "1.042" "0.964" "0.920" "337.0" "310.6" "323.2" "313.7" "351.3" "335.4" "341.0" "351.2" "325.0" "310.0" "" "" "" "" "" "" "" "" "" "" "303.0" "251.3" "292.3" "306.2" "289.9" "335.4" "255.4" "310.2" "290.8" "110.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3491083928038066110" "False" "High" "IsMasterProtein" "Q9NZM5" "Ribosome biogenesis protein NOP53 OS=Homo sapiens OX=9606 GN=NOP53 PE=1 SV=2" "0.000" "False" "10.911" "8" "3" "3" "3" "478" "54.4" "10.32" "10.16" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07767" "29997" "ENSG00000105373" "NOP53" "hsa:29997; Q9BTC6; Q9HAX6; Q9NPP1; Q9NPR4; Q9NZM5; Q9UFI2" "" "" "0" "0" "1.267" "1.204" "1.050" "1.106" "1.121" "1.368" "1.095" "1.199" "1.068" "42.2" "53.4" "50.8" "44.3" "46.7" "47.3" "57.7" "46.2" "50.6" "45.1" "" "" "" "" "" "" "" "" "" "" "37.9" "43.2" "45.9" "43.2" "38.5" "47.3" "43.2" "40.8" "45.3" "16.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1155650016836113983" "False" "High" "IsMasterProtein" "Q6NYC1" "Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Homo sapiens OX=9606 GN=JMJD6 PE=1 SV=1" "0.000" "False" "10.906" "10" "4" "4" "4" "403" "46.4" "8.69" "13.56" "4" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "23210" "ENSG00000070495" "JMJD6" "B3KMN8; B4DGX1; hsa:23210; Q6NYC1; Q86VY0; Q8IUM5; Q9Y4E2" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "1.126" "1.105" "1.000" "1.160" "1.131" "1.196" "1.147" "1.081" "1.695" "323.9" "364.8" "357.9" "323.9" "375.6" "366.4" "387.5" "371.6" "350.2" "549.1" "" "" "" "" "" "" "" "" "" "" "291.3" "295.2" "323.7" "316.2" "310.0" "366.4" "290.1" "328.3" "313.4" "196.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2978485946285835937" "False" "High" "IsMasterProtein" "Q8NHH9" "Atlastin-2 OS=Homo sapiens OX=9606 GN=ATL2 PE=1 SV=2" "0.000" "False" "10.888" "4" "2" "4" "2" "583" "66.2" "5.48" "12.97" "2" "cell organization and biogenesis" "other membranes;ER/Golgi" "other molecular function" "Pf02263, Pf02841" "64225" "ENSG00000119787" "ATL2" "B7Z1X2; B7Z7X8; hsa:64225; Q4ZG30; Q7Z630; Q8NHH8; Q8NHH9; Q9H5M7" "" "" "0" "0" "1.037" "0.858" "1.082" "0.973" "1.067" "1.039" "0.933" "0.869" "2.273" "135.7" "140.6" "116.4" "146.9" "132.0" "144.8" "141.0" "126.6" "117.9" "308.4" "" "" "" "" "" "" "" "" "" "" "122.0" "113.8" "105.2" "143.4" "108.9" "144.8" "105.6" "111.8" "105.5" "110.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5588774124192242024" "False" "High" "IsMasterProtein" "P54132" "RecQ-like DNA helicase BLM OS=Homo sapiens OX=9606 GN=BLM PE=1 SV=1" "0.000" "False" "10.882" "3" "3" "5" "2" "1417" "158.9" "7.49" "16.08" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf00570, Pf08072, Pf09382, Pf16124, Pf16202, Pf16204" "641" "ENSG00000197299" "BLM" "hsa:641; P54132; Q52M96" "Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; SUMOylation of DNA damage response and repair proteins; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; Meiotic recombination; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Processive synthesis on the C-strand of the telomere" "18" "0" "0.906" "0.908" "0.934" "1.192" "1.097" "0.880" "0.856" "1.048" "1.257" "81.9" "74.3" "74.4" "76.6" "97.7" "89.8" "72.1" "70.2" "85.9" "103.0" "" "" "" "" "" "" "" "" "" "" "73.7" "60.1" "67.3" "74.7" "80.6" "89.8" "54.0" "62.0" "76.9" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4254593612476960216" "False" "High" "IsMasterProtein" "Q9BTZ2" "Dehydrogenase/reductase SDR family member 4 OS=Homo sapiens OX=9606 GN=DHRS4 PE=1 SV=3" "0.000" "False" "10.879" "15" "5" "5" "5" "278" "29.5" "8.56" "14.64" "5" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf13561" "10901" "ENSG00000157326; ENSG00000284807" "DHRS4" "B2RB10; B7WNS9; D3YTB8; E2QRL8; hsa:10901; O95162; Q20CR0; Q2LC19; Q2LE81; Q58IU4; Q6E0Y1; Q6UWU3; Q71UQ6; Q8TD03; Q9BTZ2; Q9H3N5; Q9NV08" "" "Peroxisomal protein import; RA biosynthesis pathway" "2" "0" "0.973" "0.928" "0.961" "0.983" "1.015" "1.038" "0.924" "1.021" "0.832" "273.4" "266.1" "253.8" "262.6" "268.7" "277.4" "283.8" "252.5" "279.1" "227.5" "" "" "" "" "" "" "" "" "" "" "245.8" "215.3" "229.6" "256.4" "221.7" "277.4" "212.5" "223.0" "249.7" "81.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403254130962857546" "False" "High" "IsMasterProtein" "Q9BZ67" "FERM domain-containing protein 8 OS=Homo sapiens OX=9606 GN=FRMD8 PE=1 SV=1" "0.000" "False" "10.872" "8" "2" "4" "2" "464" "51.2" "6.23" "13.50" "2" "other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "" "Pf00373" "83786" "ENSG00000126391" "FRMD8" "B4E2P1; hsa:83786; Q86V56; Q8NCB5; Q9BZ67" "" "" "0" "0" "1.825" "1.259" "0.717" "2.122" "2.360" "1.804" "1.240" "2.265" "1.236" "32.7" "59.7" "41.2" "23.5" "69.5" "77.2" "59.0" "40.6" "74.1" "40.5" "" "" "" "" "" "" "" "" "" "" "29.4" "48.3" "37.3" "22.9" "57.3" "77.2" "44.2" "35.8" "66.3" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-410624310622087342" "False" "High" "IsMasterProtein" "Q13227" "G protein pathway suppressor 2 OS=Homo sapiens OX=9606 GN=GPS2 PE=1 SV=3" "0.000" "False" "10.871" "10" "4" "5" "4" "327" "36.7" "9.52" "18.49" "4" "stress response;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf15991" "2874" "ENSG00000132522; ENSG00000288325" "GPS2" "B4DXA1; hsa:2874; Q13227; Q6FHM8" "Rett syndrome" "HDACs deacetylate histones; PPARA activates gene expression; HCMV Early Events; Loss of MECP2 binding ability to the NCoR/SMRT complex; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "7" "0" "0.923" "0.926" "0.934" "1.060" "0.938" "1.100" "0.967" "0.906" "1.145" "540.4" "498.8" "500.4" "504.6" "573.0" "506.9" "594.4" "522.5" "489.5" "618.5" "" "" "" "" "" "" "" "" "" "" "485.9" "403.6" "452.7" "492.6" "472.8" "506.9" "445.1" "461.5" "438.0" "220.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9128432651374987381" "False" "High" "IsMasterProtein" "Q9NNW5" "tRNA (34-2'-O)-methyltransferase regulator WDR6 OS=Homo sapiens OX=9606 GN=WDR6 PE=1 SV=1" "0.000" "False" "10.868" "4" "4" "4" "4" "1121" "121.6" "6.87" "13.10" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;nucleic acid binding activity" "Pf00400" "11180" "ENSG00000178252" "WDR6" "B4DHK2; hsa:11180; Q3MIT1; Q9NNW5; Q9UF63" "" "RND2 GTPase cycle; RHOV GTPase cycle; RHOU GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5260823146616738925" "False" "High" "IsMasterProtein" "O43829" "Zinc finger and BTB domain-containing protein 14 OS=Homo sapiens OX=9606 GN=ZBTB14 PE=1 SV=2" "0.000" "False" "10.866" "9" "4" "4" "4" "449" "50.9" "6.04" "11.19" "4" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "7541" "ENSG00000198081" "ZBTB14" "hsa:7541; O00403; O43829; Q2TB80" "" "" "0" "0" "0.929" "0.740" "1.049" "0.962" "0.889" "1.014" "0.983" "0.829" "0.920" "106.8" "99.2" "79.0" "112.0" "102.7" "94.9" "108.2" "105.0" "88.5" "98.3" "" "" "" "" "" "" "" "" "" "" "96.0" "80.3" "71.5" "109.3" "84.7" "94.9" "81.0" "92.7" "79.2" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5956791852298741945" "False" "High" "IsMasterProtein" "Q9UPY8" "Microtubule-associated protein RP/EB family member 3 OS=Homo sapiens OX=9606 GN=MAPRE3 PE=1 SV=1" "0.000" "False" "10.863" "10" "3" "9" "1" "281" "32.0" "5.54" "23.92" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf03271" "22924" "ENSG00000084764" "MAPRE3" "B7WPK5; hsa:22924; O00265; Q6FHB0; Q6FI15; Q9BZP7; Q9BZP8; Q9UPY8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-715832753700784142" "False" "High" "IsMasterProtein" "P22830" "Ferrochelatase, mitochondrial OS=Homo sapiens OX=9606 GN=FECH PE=1 SV=2" "0.000" "False" "10.861" "10" "4" "4" "4" "423" "47.8" "8.73" "11.25" "4" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00762" "2235" "ENSG00000066926" "FECH" "A8KA72; hsa:2235; P22830; Q8IXN1; Q8NAN0" "Hemesynthesis defects and porphyrias; Heme biosynthesis" "Mitochondrial protein degradation; Heme biosynthesis" "4" "0" "1.041" "1.075" "0.985" "1.036" "1.068" "0.989" "0.968" "1.016" "0.905" "350.9" "365.3" "377.1" "345.5" "363.5" "374.9" "346.9" "339.5" "356.5" "317.5" "" "" "" "" "" "" "" "" "" "" "315.5" "295.6" "341.1" "337.3" "299.9" "374.9" "259.7" "299.9" "319.0" "113.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243510255652215024" "False" "High" "IsMasterProtein" "Q9Y448" "Small kinetochore-associated protein OS=Homo sapiens OX=9606 GN=KNSTRN PE=1 SV=2" "0.000" "False" "10.859" "10" "3" "3" "3" "316" "35.4" "6.30" "11.74" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "90417" "ENSG00000128944" "KNSTRN" "B4DXA7; hsa:90417; Q147U5; Q32Q57; Q5ISJ0; Q6P2S5; Q6PJM0; Q86XB4; Q9Y448" "Leukocyte-intrinsic Hippo pathway functions" "" "1" "0" "0.991" "0.840" "0.851" "1.140" "0.871" "1.068" "0.891" "0.819" "1.196" "185.3" "183.7" "155.6" "157.7" "211.2" "161.4" "198.0" "165.1" "151.9" "221.7" "" "" "" "" "" "" "" "" "" "" "166.6" "148.6" "140.8" "153.9" "174.3" "161.4" "148.2" "145.8" "135.9" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1411414456407117859" "False" "High" "IsMasterProtein" "Q7Z6K3" "Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2" "0.000" "False" "10.834" "11" "5" "6" "5" "402" "46.4" "6.99" "17.11" "5" "" "other cell component" "other molecular function" "Pf01239" "375743" "ENSG00000188647" "PTAR1" "hsa:375743; Q5T7V5; Q5T7V6; Q7Z6K3" "" "" "0" "0" "1.070" "1.028" "0.941" "1.181" "1.038" "1.057" "1.064" "1.157" "0.901" "248.8" "266.2" "255.8" "234.2" "293.9" "258.2" "263.1" "264.8" "287.8" "224.2" "" "" "" "" "" "" "" "" "" "" "223.7" "215.4" "231.4" "228.6" "242.6" "258.2" "197.0" "233.9" "257.5" "80.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5442712666023189626" "False" "High" "IsMasterProtein" "O43251" "RNA binding protein fox-1 homolog 2 OS=Homo sapiens OX=9606 GN=RBFOX2 PE=1 SV=3" "0.000" "False" "10.809" "7" "3" "3" "3" "390" "41.3" "7.27" "10.98" "3" "RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf12414" "23543" "ENSG00000100320; ENSG00000277564" "RBFOX2" "A4F5G8; A8K5Z5; B0QYY8; B0QYY9; hsa:23543; O43251; Q0PRL5; Q0VH35; Q5TF71; Q6IC09; Q8TD00; Q8WYB1; Q96DZ6; Q96NL7; Q9UGW4; Q9UH33" "Mammalian disorder of sexual development" "FGFR2 alternative splicing" "2" "0" "1.060" "0.963" "0.952" "1.085" "1.052" "1.003" "0.992" "1.121" "0.958" "84.8" "89.9" "81.7" "80.7" "92.0" "89.2" "85.1" "84.1" "95.1" "81.3" "" "" "" "" "" "" "" "" "" "" "76.2" "72.7" "73.9" "78.8" "75.9" "89.2" "63.7" "74.3" "85.1" "29.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8417991388953307590" "False" "High" "IsMasterProtein" "O75064" "DENN domain-containing protein 4B OS=Homo sapiens OX=9606 GN=DENND4B PE=1 SV=4" "0.000" "False" "10.808" "3" "4" "5" "4" "1496" "163.7" "7.21" "13.94" "4" "other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "9909" "ENSG00000198837" "DENND4B" "hsa:9909; O75064; Q5T4K0" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.959" "0.922" "0.869" "0.911" "0.912" "0.983" "0.949" "0.893" "0.952" "513.0" "492.2" "472.9" "445.7" "467.1" "467.7" "504.5" "486.9" "458.2" "488.3" "" "" "" "" "" "" "" "" "" "" "461.2" "398.2" "427.7" "435.1" "385.5" "467.7" "377.8" "430.1" "410.0" "174.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5965244756027354747" "False" "High" "IsMasterProtein" "O75414" "Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3" "0.000" "False" "10.803" "22" "4" "4" "4" "186" "21.1" "8.32" "10.57" "4" "other metabolic processes;other biological processes" "mitochondrion" "kinase activity;other molecular function" "Pf00334" "10201" "ENSG00000172113" "NME6" "B4DGW7; B4DM99; hsa:10201; O75414; Q53HM5; Q96E73; Q9BQ63" "Pyrimidine metabolism" "" "1" "0" "1.103" "1.114" "0.981" "1.143" "1.082" "1.181" "1.164" "1.114" "1.282" "349.9" "386.1" "389.6" "343.3" "399.9" "378.8" "413.1" "407.4" "389.7" "448.5" "" "" "" "" "" "" "" "" "" "" "314.6" "312.4" "352.4" "335.1" "330.0" "378.8" "309.3" "359.8" "348.7" "160.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7799027560696546609" "False" "High" "IsMasterProtein" "Q49MG5" "Microtubule-associated protein 9 OS=Homo sapiens OX=9606 GN=MAP9 PE=1 SV=3" "0.000" "False" "10.795" "7" "4" "4" "4" "647" "74.2" "7.80" "10.83" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "" "79884" "ENSG00000164114" "MAP9" "hsa:79884; Q49MG5; Q4W5I7; Q68DU1; Q9H781; Q9H7B6" "" "" "0" "0" "0.824" "0.890" "0.968" "0.943" "1.106" "0.980" "0.986" "1.077" "0.764" "142.3" "117.2" "126.7" "137.8" "134.2" "157.5" "139.5" "140.4" "153.3" "108.7" "" "" "" "" "" "" "" "" "" "" "128.0" "94.9" "114.6" "134.5" "110.7" "157.5" "104.5" "124.0" "137.1" "38.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3396014057802155010" "False" "High" "IsMasterProtein" "Q15910" "Histone-lysine N-methyltransferase EZH2 OS=Homo sapiens OX=9606 GN=EZH2 PE=1 SV=2" "0.000" "False" "10.785" "5" "3" "3" "3" "746" "85.3" "7.02" "11.54" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf11616, Pf18118, Pf18264, Pf21358" "2146" "ENSG00000106462" "EZH2" "B2RAQ1; B3KS30; B7Z1D6; B7Z7L6; hsa:2146; Q15755; Q15910; Q75MG3; Q92857; Q96FI6" "Cell differentiation - expanded index; Histone modifications; Endoderm differentiation; Interactome of polycomb repressive complex 2 (PRC2) ; MECP2 and associated Rett syndrome; Tumor suppressor activity of SMARCB1; Epithelial to mesenchymal transition in colorectal cancer; lncRNA in canonical Wnt signaling and colorectal cancer; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma; Pleural mesothelioma" "Defective pyroptosis; HCMV Early Events; Oxidative Stress Induced Senescence; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6; Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "19" "0" "1.031" "1.063" "0.921" "0.867" "1.105" "1.024" "0.878" "0.974" "1.825" "182.1" "187.7" "193.6" "167.8" "157.8" "201.2" "186.6" "159.8" "177.3" "332.4" "" "" "" "" "" "" "" "" "" "" "163.8" "151.9" "175.1" "163.8" "130.3" "201.2" "139.7" "141.2" "158.7" "118.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5843152145544884275" "False" "High" "IsMasterProtein" "Q6KC79" "Nipped-B-like protein OS=Homo sapiens OX=9606 GN=NIPBL PE=1 SV=2" "0.000" "False" "10.756" "2" "5" "5" "5" "2804" "315.9" "7.91" "9.19" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12765, Pf12830" "25836" "ENSG00000164190" "NIPBL" "hsa:25836; Q6KC79; Q6KCD6; Q6N080; Q6ZT92; Q7Z2E6; Q8N4M5; Q9Y6Y3; Q9Y6Y4" "Cohesin complex - Cornelia de Lange syndrome; NIPBL role in DNA damage - Cornelia de Lange syndrome" "Cohesin Loading onto Chromatin" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1542485656427922063" "False" "High" "IsMasterProtein" "Q6P1K2" "Polyamine-modulated factor 1 OS=Homo sapiens OX=9606 GN=PMF1 PE=1 SV=2" "0.000" "False" "10.701" "19" "4" "6" "4" "205" "23.3" "5.49" "12.66" "4" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03980" "100527963; 11243" "ENSG00000160783" "PMF1" "A8K0C5; hsa:100527963; hsa:11243; Q5TCJ8; Q5TCJ9; Q5TCK0; Q5TCK1; Q5TCK3; Q69YZ9; Q6P1K2; Q6PHR4; Q6ZVE6; Q86VJ6; Q8N4T6; Q9UBQ3" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "0.987" "1.003" "0.950" "1.014" "0.931" "1.011" "1.071" "0.927" "0.879" "281.9" "278.4" "282.8" "267.9" "285.8" "262.5" "285.0" "301.9" "261.2" "247.8" "" "" "" "" "" "" "" "" "" "" "253.5" "225.2" "255.8" "261.5" "235.8" "262.5" "213.4" "266.6" "233.8" "88.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2350737749617918576" "False" "High" "IsMasterProtein" "Q5TAQ9" "DDB1- and CUL4-associated factor 8 OS=Homo sapiens OX=9606 GN=DCAF8 PE=1 SV=1" "0.000" "False" "10.699" "5" "3" "5" "3" "597" "66.8" "5.39" "17.69" "3" "protein metabolism;other metabolic processes" "cytosol;mitochondrion;nucleus;other cell component" "" "Pf00400" "50717" "ENSG00000132716" "DCAF8" "D3DVE6; hsa:50717; Q12839; Q4QQI6; Q53F14; Q5TAQ9; Q66K50; Q68CS7; Q96E00" "" "Neddylation" "1" "0" "0.924" "0.994" "0.890" "0.913" "0.925" "0.914" "0.900" "0.920" "0.982" "676.8" "625.3" "673.1" "602.3" "618.3" "625.9" "618.8" "609.3" "622.7" "664.8" "" "" "" "" "" "" "" "" "" "" "608.5" "505.9" "608.8" "587.9" "510.2" "625.9" "463.3" "538.2" "557.1" "237.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4329245545062110439" "False" "High" "IsMasterProtein" "Q9NQ50" "Large ribosomal subunit protein mL40 OS=Homo sapiens OX=9606 GN=MRPL40 PE=1 SV=1" "0.000" "False" "10.684" "14" "3" "3" "3" "206" "24.5" "9.63" "13.96" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf09812" "64976" "ENSG00000185608" "MRPL40" "B3KVZ7; hsa:64976; O95134; Q9NQ50" "22q11.2 copy number variation syndrome" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.780" "0.749" "1.082" "1.120" "1.002" "0.974" "0.827" "0.972" "0.717" "37.2" "29.1" "27.9" "40.3" "41.7" "37.3" "36.3" "30.8" "36.2" "26.7" "" "" "" "" "" "" "" "" "" "" "33.5" "23.5" "25.2" "39.3" "34.4" "37.3" "27.2" "27.2" "32.4" "9.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "524672605360435536" "False" "High" "IsMasterProtein" "O95273" "Cyclin-D1-binding protein 1 OS=Homo sapiens OX=9606 GN=CCNDBP1 PE=1 SV=2" "0.000" "False" "10.661" "10" "4" "5" "4" "360" "40.2" "4.82" "14.09" "4" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "" "Pf13324, Pf20936" "23582" "ENSG00000166946" "CCNDBP1" "A8K3Q0; A8K3U2; hsa:23582; O95273; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3; Q9UHX9" "" "" "0" "0" "1.056" "1.307" "0.934" "1.170" "1.396" "1.020" "1.071" "1.350" "2.140" "244.8" "258.5" "320.0" "228.6" "286.3" "341.7" "249.7" "262.2" "330.3" "523.8" "" "" "" "" "" "" "" "" "" "" "220.1" "209.2" "289.5" "223.2" "236.2" "341.7" "187.0" "231.6" "295.6" "187.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342427626710048975" "False" "High" "IsMasterProtein" "Q96SW2" "Protein cereblon OS=Homo sapiens OX=9606 GN=CRBN PE=1 SV=1" "0.000" "False" "10.655" "7" "3" "3" "3" "442" "50.5" "5.63" "11.03" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf02190, Pf03226" "51185" "ENSG00000113851" "CRBN" "B2R6H4; C9IZA9; C9JAH6; hsa:51185; Q6AI62; Q6NVZ0; Q96SW2; Q9UHW4" "" "Potential therapeutics for SARS" "1" "0" "1.081" "1.055" "0.981" "1.068" "1.057" "0.986" "1.045" "1.025" "0.877" "314.9" "340.3" "332.1" "308.8" "336.2" "332.9" "310.3" "329.1" "322.8" "276.1" "" "" "" "" "" "" "" "" "" "" "283.1" "275.4" "300.4" "301.4" "277.4" "332.9" "232.4" "290.7" "288.9" "98.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5515893546974733261" "False" "High" "IsMasterProtein" "E9PRG8" "Uncharacterized protein C11orf98 OS=Homo sapiens OX=9606 GN=C11orf98 PE=1 SV=2" "0.000" "False" "10.655" "17" "2" "3" "2" "123" "14.2" "11.53" "10.59" "2" "" "" "" "Pf17719" "102288414" "ENSG00000278615" "C11orf98" "A0A0B4J220; E9PRG8; hsa:102288414" "" "" "0" "0" "1.033" "0.971" "0.803" "1.000" "0.932" "0.948" "0.887" "0.874" "0.575" "28.9" "29.8" "28.0" "23.2" "28.9" "26.9" "27.3" "25.6" "25.2" "16.6" "" "" "" "" "" "" "" "" "" "" "25.9" "24.1" "25.3" "22.6" "23.8" "26.9" "20.5" "22.6" "22.6" "5.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8571260626068012330" "False" "High" "IsMasterProtein" "Q9NXK8" "F-box/LRR-repeat protein 12 OS=Homo sapiens OX=9606 GN=FBXL12 PE=1 SV=1" "0.000" "False" "10.638" "11" "3" "3" "3" "326" "37.0" "8.79" "12.13" "3" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf12937" "54850" "ENSG00000127452" "FBXL12" "B3KSJ8; hsa:54850; Q9H5K4; Q9NXK8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.995" "1.043" "0.921" "1.006" "0.944" "0.965" "0.986" "1.042" "1.270" "346.6" "345.1" "361.6" "319.1" "348.7" "327.4" "334.4" "341.9" "361.0" "440.1" "" "" "" "" "" "" "" "" "" "" "311.7" "279.2" "327.1" "311.5" "287.8" "327.4" "250.4" "302.0" "323.1" "157.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3529380218292263569" "False" "High" "IsMasterProtein" "P05423" "DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens OX=9606 GN=POLR3D PE=1 SV=2" "0.000" "False" "10.630" "8" "3" "3" "3" "398" "44.4" "6.98" "10.79" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05132" "661" "ENSG00000168495" "POLR3D" "hsa:661; P05423; Q6FI28; Q9BPV7; Q9BPZ1; Q9BXB3" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5269036548224773448" "False" "High" "IsMasterProtein" "Q6UXH1" "Protein disulfide isomerase CRELD2 OS=Homo sapiens OX=9606 GN=CRELD2 PE=1 SV=1" "0.000" "False" "10.596" "8" "3" "3" "3" "353" "38.2" "4.59" "7.86" "3" "" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf07645" "79174" "ENSG00000184164" "CRELD2" "A5GZA2; A5GZA3; A5GZA4; A5GZA5; A5GZA6; hsa:79174; Q4W0V0; Q6UXH1; Q86UC0; Q9BU47" "" "" "0" "0" "0.796" "1.063" "0.713" "0.782" "0.810" "0.676" "0.735" "0.678" "0.681" "156.6" "124.7" "166.4" "111.6" "122.4" "126.9" "105.9" "115.1" "106.2" "106.7" "" "" "" "" "" "" "" "" "" "" "140.8" "100.9" "150.5" "108.9" "101.0" "126.9" "79.3" "101.7" "95.1" "38.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2436639350970849740" "False" "High" "IsMasterProtein" "Q9UHB4" "NADPH-dependent diflavin oxidoreductase 1 OS=Homo sapiens OX=9606 GN=NDOR1 PE=1 SV=1" "0.000" "False" "10.571" "7" "3" "3" "3" "597" "66.7" "6.35" "11.17" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "27158" "ENSG00000188566" "NDOR1" "D3YTG6; D3YTH9; hsa:27158; Q5VSG4; Q86US9; Q96BC6; Q9UHB4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "1.062" "1.073" "0.917" "1.139" "1.197" "1.046" "1.012" "1.054" "0.994" "193.6" "205.5" "207.7" "177.5" "220.6" "231.7" "202.5" "195.9" "204.1" "192.5" "" "" "" "" "" "" "" "" "" "" "174.0" "166.3" "187.9" "173.2" "182.0" "231.7" "151.6" "173.1" "182.6" "68.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6571071577836756123" "False" "High" "IsMasterProtein" "Q9NUP1" "Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Homo sapiens OX=9606 GN=BLOC1S4 PE=1 SV=1" "0.000" "False" "10.569" "17" "3" "4" "3" "217" "23.3" "4.98" "12.85" "3" "cell adhesion;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "cytosol;other cell component" "" "" "55330" "ENSG00000186222" "BLOC1S4" "hsa:55330; Q6NVY6; Q96G84; Q9NUP1" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.979" "1.036" "1.026" "1.043" "1.115" "1.096" "1.026" "1.060" "1.129" "313.2" "306.7" "324.4" "321.4" "326.5" "349.3" "343.1" "321.2" "332.1" "353.5" "" "" "" "" "" "" "" "" "" "" "281.6" "248.2" "293.5" "313.7" "269.4" "349.3" "256.9" "283.7" "297.2" "126.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7327599600572382898" "False" "High" "IsMasterProtein" "P08473" "Neprilysin OS=Homo sapiens OX=9606 GN=MME PE=1 SV=2" "0.000" "False" "10.541" "5" "4" "5" "4" "750" "85.5" "5.73" "15.94" "4" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01431, Pf05649" "4311" "ENSG00000196549" "MME" "A8K6U6; D3DNJ9; hsa:4311; P08473; Q3MIX4" "Alzheimer's disease and miRNA effects; Primary focal segmental glomerulosclerosis (FSGS); Alzheimer's disease" "Neutrophil degranulation; Metabolism of Angiotensinogen to Angiotensins; Physiological factors" "6" "0" "0.923" "0.916" "0.942" "1.002" "0.909" "0.963" "1.004" "1.044" "0.872" "522.2" "482.0" "478.5" "491.9" "523.4" "474.6" "503.0" "524.3" "545.0" "455.4" "" "" "" "" "" "" "" "" "" "" "469.5" "390.0" "432.8" "480.1" "431.9" "474.6" "376.7" "463.1" "487.6" "162.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4678408440687391789" "False" "High" "IsMasterProtein" "Q9UFW8" "CGG triplet repeat-binding protein 1 OS=Homo sapiens OX=9606 GN=CGGBP1 PE=1 SV=2" "0.000" "False" "10.537" "28" "4" "4" "4" "167" "18.8" "8.95" "10.79" "4" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "8545" "ENSG00000163320" "CGGBP1" "D3DU38; hsa:8545; O15183; Q9UFW8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-425292061037693979" "False" "High" "IsMasterProtein" "Q9HBR0" "Solute carrier family 38 member 10 OS=Homo sapiens OX=9606 GN=SLC38A10 PE=1 SV=2" "0.000" "False" "10.528" "3" "3" "3" "3" "1119" "119.7" "5.73" "8.65" "3" "transport;developmental processes" "other membranes;ER/Golgi" "transporter activity" "Pf01490" "124565" "ENSG00000157637" "SLC38A10" "hsa:124565; Q6ZRC5; Q8NA99; Q96C66; Q9HBR0" "" "" "0" "0" "0.921" "0.726" "1.064" "0.817" "0.918" "0.924" "0.843" "0.717" "0.589" "40.4" "37.2" "29.3" "43.0" "33.0" "37.1" "37.3" "34.1" "29.0" "23.8" "" "" "" "" "" "" "" "" "" "" "36.3" "30.1" "26.5" "41.9" "27.2" "37.1" "27.9" "30.1" "25.9" "8.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6886715533770445791" "False" "High" "IsMasterProtein" "P23025" "DNA repair protein complementing XP-A cells OS=Homo sapiens OX=9606 GN=XPA PE=1 SV=1" "0.000" "False" "10.498" "15" "3" "3" "3" "273" "31.3" "6.73" "13.31" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01286, Pf05181" "7507" "ENSG00000136936" "XPA" "hsa:7507; P23025; Q5T1U9; Q6LCW7; Q6LD02" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "7" "0" "0.976" "1.084" "1.024" "1.017" "1.043" "1.075" "1.048" "1.119" "1.930" "286.0" "279.0" "310.1" "292.7" "290.8" "298.3" "307.3" "299.7" "320.1" "551.8" "" "" "" "" "" "" "" "" "" "" "257.1" "225.8" "280.5" "285.8" "239.9" "298.3" "230.1" "264.7" "286.4" "197.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7473966995224482536" "False" "High" "IsMasterProtein" "Q13233" "Mitogen-activated protein kinase kinase kinase 1 OS=Homo sapiens OX=9606 GN=MAP3K1 PE=1 SV=4" "0.000" "False" "10.469" "3" "3" "4" "3" "1512" "164.4" "7.74" "13.46" "3" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069, Pf04434, Pf21040" "4214" "ENSG00000095015" "MAP3K1" "hsa:4214; Q13233" "IL-1 signaling pathway; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; Angiopoietin-like protein 8 regulatory pathway; BMP signaling in eyelid development; Oxidative damage response; PDGFR-beta pathway; p38 MAPK signaling pathway; MAPK cascade; EGF/EGFR signaling pathway; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Hepatitis B infection; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; Interferon type I signaling pathways; DNA damage response (only ATM dependent); Serotonin HTR1 group and FOS pathway" "MyD88:MAL(TIRAP) cascade initiated on plasma membrane; FCERI mediated MAPK activation; TRAF6 mediated NF-kB activation; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane" "32" "0" "1.029" "1.013" "0.988" "1.098" "1.008" "1.111" "1.098" "0.984" "1.081" "316.1" "325.2" "320.1" "312.3" "347.2" "318.6" "351.1" "347.0" "311.1" "341.7" "" "" "" "" "" "" "" "" "" "" "284.2" "263.1" "289.6" "304.9" "286.5" "318.6" "262.9" "306.5" "278.3" "122.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8826640121646055106" "False" "High" "IsMasterProtein" "P13473" "Lysosome-associated membrane glycoprotein 2 OS=Homo sapiens OX=9606 GN=LAMP2 PE=1 SV=2" "0.000" "False" "10.447" "5" "2" "4" "2" "410" "44.9" "5.63" "17.72" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3920" "ENSG00000005893" "LAMP2" "A8K4X5; D3DTF0; hsa:3920; P13473; Q16641; Q6Q3G8; Q96J30; Q99534; Q9UD93" "Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Clock-controlled autophagy in bone metabolism" "Neutrophil degranulation; Platelet degranulation ; Chaperone Mediated Autophagy" "5" "0" "0.904" "0.941" "0.987" "1.026" "0.969" "1.062" "0.993" "1.001" "0.820" "414.9" "375.1" "390.5" "409.4" "425.8" "401.8" "440.8" "411.9" "415.4" "340.3" "" "" "" "" "" "" "" "" "" "" "373.0" "303.5" "353.3" "399.7" "351.4" "401.8" "330.1" "363.8" "371.7" "121.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4123477520333659496" "False" "High" "IsMasterProtein" "Q7Z4G4" "tRNA (guanine(10)-N2)-methyltransferase homolog OS=Homo sapiens OX=9606 GN=TRMT11 PE=1 SV=1" "0.000" "False" "10.445" "8" "4" "4" "4" "463" "53.4" "7.78" "13.58" "4" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity" "Pf01170" "60487" "ENSG00000066651" "TRMT11" "E1P570; hsa:60487; Q5JY11; Q6PGQ5; Q7Z4G4; Q9HC13" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.910" "0.953" "0.981" "0.922" "1.081" "0.888" "1.145" "1.125" "0.892" "184.3" "167.7" "175.7" "180.7" "169.9" "199.1" "163.7" "211.0" "207.3" "164.4" "" "" "" "" "" "" "" "" "" "" "165.7" "135.7" "158.9" "176.4" "140.2" "199.1" "122.6" "186.3" "185.5" "58.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4778122268276291111" "False" "High" "IsMasterProtein" "P49406" "Large ribosomal subunit protein bL19m OS=Homo sapiens OX=9606 GN=MRPL19 PE=1 SV=2" "0.000" "False" "10.423" "10" "3" "3" "3" "292" "33.5" "9.50" "10.18" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01245" "9801" "ENSG00000115364" "MRPL19" "hsa:9801; P49406; Q53TX9; Q96Q52" "Cytoplasmic ribosomal proteins" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.994" "0.892" "0.927" "1.010" "1.034" "1.148" "0.921" "1.069" "1.570" "156.6" "155.7" "139.6" "145.2" "158.2" "162.0" "179.7" "144.3" "167.4" "245.9" "" "" "" "" "" "" "" "" "" "" "140.8" "126.0" "126.3" "141.7" "130.6" "162.0" "134.6" "127.4" "149.8" "87.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8487408262660345487" "False" "High" "IsMasterProtein" "P11388" "DNA topoisomerase 2-alpha OS=Homo sapiens OX=9606 GN=TOP2A PE=1 SV=3" "0.000" "False" "10.405" "2" "4" "5" "3" "1531" "174.3" "8.72" "17.25" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00204, Pf00521, Pf01751, Pf02518, Pf08070, Pf16898" "7153" "ENSG00000131747" "TOP2A" "B2RTS1; hsa:7153; P11388; Q71UN1; Q71UQ5; Q9HB24; Q9HB25; Q9HB26; Q9UP44; Q9UQP9" "Gastric cancer network 1; Gastric cancer network 2; Retinoblastoma gene in cancer" "SUMOylation of DNA replication proteins; Transcription of E2F targets under negative control by DREAM complex" "5" "0" "0.996" "0.922" "0.928" "0.910" "1.138" "0.877" "0.911" "0.744" "0.867" "219.3" "218.4" "202.2" "203.4" "199.7" "249.5" "192.4" "199.9" "163.1" "190.2" "" "" "" "" "" "" "" "" "" "" "197.2" "176.7" "182.9" "198.6" "164.8" "249.5" "144.1" "176.5" "146.0" "67.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5274992111862833065" "False" "High" "IsMasterProtein" "Q8IXJ6" "NAD-dependent protein deacetylase sirtuin-2 OS=Homo sapiens OX=9606 GN=SIRT2 PE=1 SV=2" "0.000" "False" "10.383" "10" "3" "3" "3" "389" "43.2" "5.36" "11.48" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02146" "22933" "ENSG00000068903; ENSG00000283100" "SIRT2" "A8K3V1; B2RB45; hsa:22933; O95889; Q8IXJ6; Q924Y7; Q9P0G8; Q9UNT0; Q9Y6E9; U5TP13" "NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; HDAC6 interactions in the central nervous system" "Initiation of Nuclear Envelope (NE) Reformation" "5" "0" "1.059" "1.046" "1.000" "1.121" "1.075" "1.126" "1.037" "1.076" "1.127" "229.6" "243.3" "240.2" "229.5" "257.3" "246.8" "258.5" "238.0" "247.0" "258.7" "" "" "" "" "" "" "" "" "" "" "206.4" "196.8" "217.3" "224.0" "212.3" "246.8" "193.5" "210.2" "221.0" "92.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4278249940828633973" "False" "High" "IsMasterProtein" "P32321" "Deoxycytidylate deaminase OS=Homo sapiens OX=9606 GN=DCTD PE=1 SV=2" "0.000" "False" "10.382" "15" "3" "3" "3" "178" "20.0" "7.56" "10.86" "3" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00383" "1635" "ENSG00000129187" "DCTD" "B2R836; D3DP49; D3DP50; hsa:1635; P32321; Q5M7Z8; Q9BVD8" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "0.956" "0.920" "0.954" "1.104" "0.929" "1.011" "0.975" "0.917" "0.749" "411.6" "393.5" "378.5" "392.7" "454.5" "382.5" "415.9" "401.3" "377.3" "308.2" "" "" "" "" "" "" "" "" "" "" "370.1" "318.4" "342.4" "383.3" "375.0" "382.5" "311.4" "354.4" "337.6" "110.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400072782813286453" "False" "High" "IsMasterProtein" "P62424" "Large ribosomal subunit protein eL8 OS=Homo sapiens OX=9606 GN=RPL7A PE=1 SV=2" "0.000" "False" "10.376" "11" "3" "3" "3" "266" "30.0" "10.61" "11.32" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "other membranes;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01248" "6130" "ENSG00000148303; ENSG00000280858" "RPL7A" "hsa:6130; P11518; P62424; Q5T8U4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.846" "0.837" "0.881" "0.900" "0.897" "0.811" "0.936" "0.905" "0.778" "278.1" "235.4" "232.8" "244.9" "250.4" "249.4" "225.7" "260.5" "251.8" "216.3" "" "" "" "" "" "" "" "" "" "" "250.1" "190.5" "210.6" "239.1" "206.6" "249.4" "169.0" "230.1" "225.3" "77.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3408450596310404748" "False" "High" "IsMasterProtein" "Q9UHA4" "Ragulator complex protein LAMTOR3 OS=Homo sapiens OX=9606 GN=LAMTOR3 PE=1 SV=1" "0.000" "False" "10.352" "21" "2" "4" "2" "124" "13.6" "7.34" "15.70" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf08923" "8649" "ENSG00000109270" "LAMTOR3" "B2R4A1; hsa:8649; J3KMX4; Q9H364; Q9UHA4" "MAPK signaling pathway; MAPK cascade; Gastrin signaling pathway; Melanoma" "Neutrophil degranulation; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes; Regulation of PTEN gene transcription; MAP2K and MAPK activation; mTORC1-mediated signalling; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "13" "0" "1.150" "1.069" "1.015" "1.189" "1.131" "1.185" "1.021" "1.067" "0.797" "330.8" "380.4" "353.7" "335.8" "393.3" "374.2" "392.0" "337.7" "353.0" "263.7" "" "" "" "" "" "" "" "" "" "" "297.4" "307.8" "319.9" "327.7" "324.6" "374.2" "293.5" "298.3" "315.9" "94.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7996509007212382339" "False" "High" "IsMasterProtein" "B2RTY4" "Unconventional myosin-IXa OS=Homo sapiens OX=9606 GN=MYO9A PE=1 SV=2" "0.000" "False" "10.344" "2" "4" "5" "4" "2548" "292.5" "8.88" "8.77" "4" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00063, Pf00130, Pf00612, Pf00620, Pf00788" "4649" "ENSG00000066933" "MYO9A" "B0I1T5; B2RTY4; C9IYB3; C9JA86; hsa:4649; Q14787; Q3YLD7; Q3YLD8; Q6P986; Q9H8T5; Q9NTG2; Q9NUY2; Q9UEP3; Q9UNJ2" "" "RHOA GTPase cycle; RHOB GTPase cycle; RHOV GTPase cycle" "3" "0" "0.975" "1.028" "1.036" "1.077" "0.951" "1.063" "0.973" "0.919" "1.176" "79.8" "77.8" "82.0" "82.6" "85.9" "75.8" "84.8" "77.6" "73.3" "93.8" "" "" "" "" "" "" "" "" "" "" "71.7" "62.9" "74.2" "80.6" "70.9" "75.8" "63.5" "68.5" "65.6" "33.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8782034775898615298" "False" "High" "IsMasterProtein" "Q96NC0" "Zinc finger matrin-type protein 2 OS=Homo sapiens OX=9606 GN=ZMAT2 PE=1 SV=1" "0.000" "False" "10.341" "17" "3" "5" "3" "199" "23.6" "9.01" "17.52" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12171" "153527" "ENSG00000146007" "ZMAT2" "hsa:153527; Q96NC0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.865" "0.999" "0.948" "0.922" "0.924" "0.876" "0.935" "0.942" "0.712" "387.8" "335.3" "387.4" "367.6" "357.6" "358.5" "339.7" "362.5" "365.4" "276.2" "" "" "" "" "" "" "" "" "" "" "348.7" "271.3" "350.4" "358.9" "295.1" "358.5" "254.4" "320.2" "327.0" "98.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2534211096191502147" "False" "High" "IsMasterProtein" "O00560" "Syntenin-1 OS=Homo sapiens OX=9606 GN=SDCBP PE=1 SV=1" "0.000" "False" "10.335" "10" "2" "3" "2" "298" "32.4" "7.53" "13.16" "2" "cell-cell signaling;cell organization and biogenesis;protein metabolism;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595" "6386" "ENSG00000137575" "SDCBP" "B2R5Q7; B4DUH3; B7ZLN2; O00173; O00560; O43391; Q14CP2" "Ectoderm differentiation; Ectoderm differentiation; VEGFA-VEGFR2 signaling; 11p11.2 copy number variation syndrome" "Neutrophil degranulation; Ephrin signaling; Neurofascin interactions; Regulation of necroptotic cell death" "9" "0" "1.077" "1.152" "1.070" "1.106" "1.252" "1.233" "1.133" "1.372" "0.759" "66.8" "71.9" "77.0" "71.5" "73.9" "83.6" "82.3" "75.7" "91.7" "50.7" "" "" "" "" "" "" "" "" "" "" "60.0" "58.2" "69.6" "69.8" "61.0" "83.6" "61.7" "66.9" "82.0" "18.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6707241685728679125" "False" "High" "IsMasterProtein" "Q9NY93" "Probable ATP-dependent RNA helicase DDX56 OS=Homo sapiens OX=9606 GN=DDX56 PE=1 SV=1" "0.000" "False" "10.329" "5" "3" "3" "3" "547" "61.6" "9.26" "11.26" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "54606" "ENSG00000136271" "DDX56" "A4D2K9; C9JV95; hsa:54606; Q6IAE2; Q9H9I8; Q9NY93" "" "" "0" "0" "1.125" "0.761" "1.111" "1.185" "0.742" "1.225" "1.122" "0.641" "0.902" "260.8" "293.5" "198.4" "289.8" "308.9" "193.4" "319.5" "292.5" "167.1" "235.1" "" "" "" "" "" "" "" "" "" "" "234.5" "237.5" "179.5" "282.9" "254.9" "193.4" "239.2" "258.4" "149.5" "83.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2882906632265539377" "False" "High" "IsMasterProtein" "Q9NQV6" "PR domain zinc finger protein 10 OS=Homo sapiens OX=9606 GN=PRDM10 PE=1 SV=3" "0.000" "False" "10.321" "3" "3" "3" "3" "1147" "130.1" "6.74" "10.52" "3" "other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf21549" "56980" "ENSG00000170325" "PRDM10" "B7ZL71; G3XAE5; hsa:56980; J3KP23; Q17R90; Q2KHR4; Q863Z2; Q9NQV6; Q9NXI4; Q9ULI9" "" "" "0" "0" "1.014" "1.006" "1.114" "1.192" "0.917" "0.997" "1.001" "1.185" "1.383" "33.3" "33.8" "33.5" "37.1" "39.7" "30.6" "33.2" "33.4" "39.5" "46.1" "" "" "" "" "" "" "" "" "" "" "30.0" "27.4" "30.3" "36.2" "32.8" "30.6" "24.9" "29.5" "35.3" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8654378889917812669" "False" "High" "IsMasterProtein" "Q9BQ90" "Kelch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KLHDC3 PE=1 SV=1" "0.000" "False" "10.320" "12" "3" "3" "3" "382" "43.1" "8.07" "13.46" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01344, Pf07646, Pf13418, Pf13964" "116138" "ENSG00000124702" "KLHDC3" "A8K2W9; hsa:116138; Q9BQ90" "" "XBP1(S) activates chaperone genes" "1" "0" "1.101" "1.086" "0.875" "0.972" "0.995" "0.958" "1.075" "1.020" "0.833" "149.1" "164.2" "162.0" "130.4" "145.0" "148.4" "142.8" "160.3" "152.2" "124.2" "" "" "" "" "" "" "" "" "" "" "134.1" "132.8" "146.5" "127.3" "119.6" "148.4" "106.9" "141.6" "136.2" "44.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316377890206410152" "False" "High" "IsMasterProtein" "Q00536" "Cyclin-dependent kinase 16 OS=Homo sapiens OX=9606 GN=CDK16 PE=1 SV=1" "0.000" "False" "10.318" "5" "3" "5" "2" "496" "55.7" "7.62" "17.99" "3" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5127" "ENSG00000102225" "CDK16" "A8K280; B7Z7C8; hsa:5127; J3KN74; J3KQP7; Q00536" "" "" "0" "0" "1.015" "1.220" "1.087" "1.084" "1.000" "1.094" "1.218" "1.031" "1.066" "315.8" "320.5" "385.4" "343.1" "342.2" "315.9" "345.4" "384.8" "325.6" "336.6" "" "" "" "" "" "" "" "" "" "" "283.9" "259.4" "348.6" "334.9" "282.4" "315.9" "258.7" "339.9" "291.3" "120.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8120916206400470693" "False" "High" "IsMasterProtein" "O96006" "E3 SUMO-protein ligase ZBED1 OS=Homo sapiens OX=9606 GN=ZBED1 PE=1 SV=1" "0.000" "False" "10.311" "5" "3" "3" "3" "694" "78.1" "6.10" "10.22" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02892, Pf05699" "9189" "ENSG00000214717; ENSG00000292345" "ZBED1" "hsa:9189; O96006; Q96BY4" "" "SUMOylation of chromatin organization proteins" "1" "0" "0.986" "1.175" "1.037" "0.979" "1.052" "0.859" "0.992" "1.117" "1.687" "192.1" "189.5" "225.6" "199.2" "188.0" "202.1" "165.0" "190.4" "214.5" "323.9" "" "" "" "" "" "" "" "" "" "" "172.7" "153.3" "204.0" "194.4" "155.2" "202.1" "123.5" "168.2" "191.9" "115.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5902665754527388004" "False" "High" "IsMasterProtein" "Q969R8" "KICSTOR complex protein ITFG2 OS=Homo sapiens OX=9606 GN=ITFG2 PE=1 SV=1" "0.000" "False" "10.309" "6" "2" "3" "2" "447" "49.3" "5.22" "10.25" "2" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "" "Pf15907" "55846" "ENSG00000111203" "ITFG2" "A8K4Z5; D3DUQ2; hsa:55846; Q6PKU5; Q969R8; Q96SX6" "" "Amino acids regulate mTORC1" "1" "0" "1.058" "0.802" "0.872" "1.049" "1.156" "0.733" "1.192" "0.847" "1.038" "51.3" "54.3" "41.1" "44.7" "53.8" "59.3" "37.6" "61.1" "43.4" "53.2" "" "" "" "" "" "" "" "" "" "" "46.1" "43.9" "37.2" "43.7" "44.4" "59.3" "28.2" "54.0" "38.9" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196973949191465790" "False" "High" "IsMasterProtein" "P07686" "Beta-hexosaminidase subunit beta OS=Homo sapiens OX=9606 GN=HEXB PE=1 SV=4" "0.000" "False" "10.305" "7" "3" "3" "2" "556" "63.1" "6.76" "10.46" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00728, Pf14845" "3074" "ENSG00000049860" "HEXB" "hsa:3074; P07686" "Glycosaminoglycan degradation" "Neutrophil degranulation; CS/DS degradation; Hyaluronan uptake and degradation; Glycosphingolipid catabolism; Keratan sulfate degradation; Defective HEXB causes GM2G2" "7" "0" "0.876" "1.090" "1.062" "0.963" "1.029" "0.886" "0.915" "1.080" "0.824" "101.4" "88.9" "110.5" "107.7" "97.7" "104.3" "89.8" "92.8" "109.5" "83.5" "" "" "" "" "" "" "" "" "" "" "91.2" "71.9" "100.0" "105.1" "80.6" "104.3" "67.3" "82.0" "98.0" "29.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1536948539302412641" "False" "High" "IsMasterProtein" "O60927" "E3 ubiquitin-protein ligase PPP1R11 OS=Homo sapiens OX=9606 GN=PPP1R11 PE=1 SV=1" "0.000" "False" "10.290" "33" "3" "3" "3" "126" "13.9" "7.01" "12.84" "3" "protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf07491" "6992" "ENSG00000204619; ENSG00000206501; ENSG00000227720; ENSG00000233314; ENSG00000234058; ENSG00000236560; ENSG00000237403; ENSG00000237829" "PPP1R11" "hsa:6992; O60927" "" "" "0" "0" "1.095" "0.984" "0.997" "1.124" "1.114" "1.113" "1.031" "1.198" "1.382" "116.6" "127.7" "114.7" "116.3" "131.0" "129.9" "129.7" "120.2" "139.7" "161.1" "" "" "" "" "" "" "" "" "" "" "104.8" "103.3" "103.8" "113.5" "108.1" "129.9" "97.1" "106.2" "125.0" "57.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1892947756111346869" "False" "High" "IsMasterProtein" "P42345" "Serine/threonine-protein kinase mTOR OS=Homo sapiens OX=9606 GN=MTOR PE=1 SV=1" "0.000" "False" "10.288" "2" "4" "5" "4" "2549" "288.7" "7.17" "13.83" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "translation activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00454, Pf02259, Pf02260, Pf08771, Pf11865" "2475" "ENSG00000198793" "MTOR" "hsa:2475; P42345; Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3" "AMP-activated protein kinase signaling; Target of rapamycin signaling; MicroRNAs in cardiomyocyte hypertrophy; Type II diabetes mellitus; Sterol regulatory element-binding proteins (SREBP) signaling; SREBF and miR33 in cholesterol and lipid homeostasis; RANKL/RANK signaling pathway; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Follicle stimulating hormone (FSH) signaling pathway; Prolactin signaling pathway; Alzheimer's disease and miRNA effects; Thymic stromal lymphopoietin (TSLP) signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Alpha 6 beta 4 signaling pathway; Polycystic kidney disease pathway; Cardiac hypertrophic response; Extracellular vesicle-mediated signaling in recipient cells; TSLP signaling pathway; Ovarian infertility; MECP2 and associated Rett syndrome; Wnt signaling pathway; BDNF-TrkB signaling; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; ATM signaling in development and disease ; 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of prostate cancer signaling pathways; Clear cell renal cell carcinoma pathways; PI3K/AKT/mTOR - vitamin D3 signaling; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Caloric restriction and aging; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Thermogenesis; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Hippo signaling regulation pathways; Fragile X syndrome; Translation inhibitors in chronically activated PDGFRA cells; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Joubert syndrome; Gastrin signaling pathway; Head and neck squamous cell carcinoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; Regucalcin in proximal tubule epithelial kidney cells; CAMKK2 pathway; Neuroinflammation; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Network map of SARS-CoV-2 signaling pathway; Sphingolipid metabolism in senescence; Alzheimer's disease; Th17 cell differentiation pathway; GDNF signaling; DYRK1A involvement regarding cell proliferation in brain development; Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids; Clock-controlled autophagy in bone metabolism; Warburg effect modulated by deubiquitinating enzymes and their substrates; Acute myeloid leukemia; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; JAK-STAT signaling in the regulation of beta cells; ADHD and autism (ASD) linked metabolic pathways and SNP; GNAQ pathways in port-wine stain; Artemisinin inhibition of uveal melanoma; Interferon type I signaling pathways; ErbB signaling pathway" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability; HSF1-dependent transactivation" "92" "0" "0.796" "0.720" "0.714" "0.699" "0.825" "0.875" "0.957" "0.825" "1.135" "57.5" "45.8" "41.4" "41.1" "40.2" "47.4" "50.3" "55.1" "47.5" "65.3" "" "" "" "" "" "" "" "" "" "" "51.7" "37.1" "37.5" "40.1" "33.2" "47.4" "37.7" "48.6" "42.5" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7491273576453503015" "False" "High" "IsMasterProtein" "Q9BYN0" "Sulfiredoxin-1 OS=Homo sapiens OX=9606 GN=SRXN1 PE=1 SV=2" "0.000" "False" "10.266" "30" "3" "4" "3" "137" "14.3" "8.19" "12.69" "3" "stress response;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "" "140809" "ENSG00000271303" "SRXN1" "B2R543; hsa:140809; Q8NDM3; Q96AK6; Q9BYN0" "Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling" "NFE2L2 regulating anti-oxidant/detoxification enzymes" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3449420204754272229" "False" "High" "IsMasterProtein" "Q9NV56" "MRG/MORF4L-binding protein OS=Homo sapiens OX=9606 GN=MRGBP PE=1 SV=1" "0.000" "False" "10.254" "10" "2" "3" "2" "204" "22.4" "5.83" "12.49" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf07904" "55257" "ENSG00000101189" "MRGBP" "A8C4L5; hsa:55257; Q9NV56" "" "HATs acetylate histones" "1" "0" "0.937" "0.972" "0.907" "0.956" "0.976" "1.039" "0.960" "0.982" "0.852" "311.4" "291.8" "302.6" "282.3" "297.5" "303.9" "323.5" "298.9" "305.7" "265.2" "" "" "" "" "" "" "" "" "" "" "279.9" "236.1" "273.7" "275.6" "245.5" "303.9" "242.3" "264.0" "273.5" "94.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "673060285531934523" "False" "High" "IsMasterProtein" "Q8IWF6" "Protein DENND6A OS=Homo sapiens OX=9606 GN=DENND6A PE=1 SV=1" "0.000" "False" "10.250" "9" "5" "5" "5" "608" "69.5" "8.27" "13.46" "5" "other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf09794" "201627" "ENSG00000174839" "DENND6A" "hsa:201627; Q7Z5T4; Q8IWF6; Q8N235; Q8TEG8" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.096" "1.043" "1.023" "1.106" "0.999" "1.089" "1.146" "1.007" "1.134" "458.9" "503.0" "478.9" "469.6" "507.4" "458.5" "499.8" "526.1" "462.2" "520.6" "" "" "" "" "" "" "" "" "" "" "412.6" "407.0" "433.2" "458.4" "418.7" "458.5" "374.2" "464.7" "413.5" "185.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2137226823831967498" "False" "High" "IsMasterProtein" "Q0VD83" "Apolipoprotein B receptor OS=Homo sapiens OX=9606 GN=APOBR PE=1 SV=3" "0.000" "False" "10.243" "4" "3" "3" "3" "1097" "115.6" "4.40" "10.18" "3" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "" "55911" "ENSG00000184730" "APOBR" "H3BU97; hsa:55911; Q0VD81; Q0VD83; Q8NC15; Q9NPJ9" "" "VLDL clearance" "1" "0" "0.950" "1.045" "1.068" "0.913" "1.006" "0.955" "1.075" "0.982" "0.769" "85.1" "80.9" "89.0" "91.0" "77.7" "85.7" "81.3" "91.5" "83.6" "65.5" "" "" "" "" "" "" "" "" "" "" "76.6" "65.5" "80.5" "88.8" "64.1" "85.7" "60.9" "80.8" "74.8" "23.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1627020223265262766" "False" "High" "IsMasterProtein" "Q8N0W3" "L-fucose kinase OS=Homo sapiens OX=9606 GN=FCSK PE=1 SV=2" "0.000" "False" "10.243" "4" "4" "4" "4" "1084" "117.5" "6.25" "12.81" "4" "other metabolic processes;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf07959, Pf08544" "197258" "ENSG00000157353" "FCSK" "hsa:197258; Q5PSM3; Q5XKL6; Q6ZRA0; Q8N0W3; Q96MT9" "" "GDP-fucose biosynthesis" "1" "0" "1.057" "1.071" "0.942" "0.996" "0.964" "1.150" "0.985" "1.054" "0.892" "163.4" "172.8" "175.0" "153.9" "162.8" "157.6" "188.0" "161.0" "172.3" "145.8" "" "" "" "" "" "" "" "" "" "" "146.9" "139.8" "158.2" "150.3" "134.4" "157.6" "140.8" "142.2" "154.2" "52.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1812209145391096347" "False" "High" "IsMasterProtein" "P07919" "Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRH PE=1 SV=2" "0.000" "False" "10.229" "36" "3" "4" "3" "91" "10.7" "4.44" "13.52" "3" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf02320" "7388" "ENSG00000173660" "UQCRH" "B2R4V9; D3DQ18; hsa:7388; P07919; Q5TDF6; Q6LDB8; Q9BQ91" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Respiratory electron transport" "4" "0" "1.213" "1.306" "0.980" "1.131" "1.240" "1.158" "1.193" "1.261" "0.886" "376.3" "456.6" "491.5" "368.8" "425.7" "466.5" "435.7" "448.8" "474.4" "333.3" "" "" "" "" "" "" "" "" "" "" "338.3" "369.5" "444.6" "360.0" "351.3" "466.5" "326.2" "396.4" "424.4" "119.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5292178720609404720" "False" "High" "IsMasterProtein" "Q16667" "Cyclin-dependent kinase inhibitor 3 OS=Homo sapiens OX=9606 GN=CDKN3 PE=1 SV=1" "0.000" "False" "10.219" "15" "3" "4" "3" "212" "23.8" "6.40" "12.48" "3" "cell cycle OR cell proliferation;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05706" "1033" "ENSG00000100526" "CDKN3" "hsa:1033; Q16667; Q53ZU6; Q5U0M4; Q6P1N8; Q99585; Q9BPW7; Q9BY36; Q9C042; Q9C046; Q9C047; Q9C049; Q9C051; Q9C053" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4861296984398641120" "False" "High" "IsMasterProtein" "P34910" "Protein EVI2B OS=Homo sapiens OX=9606 GN=EVI2B PE=1 SV=2" "0.000" "False" "10.213" "6" "2" "3" "2" "448" "48.6" "4.83" "11.58" "2" "other biological processes" "plasma membrane;other membranes" "" "" "2124" "ENSG00000185862; ENSG00000291721" "EVI2B" "B7Z4A7; hsa:2124; P34910" "NF1 copy number variation syndrome" "" "1" "0" "0.953" "0.803" "1.007" "1.036" "0.873" "1.025" "0.989" "0.927" "0.754" "131.3" "125.2" "105.4" "132.3" "136.0" "114.6" "134.6" "129.9" "121.8" "99.0" "" "" "" "" "" "" "" "" "" "" "118.1" "101.3" "95.4" "129.1" "112.2" "114.6" "100.8" "114.7" "109.0" "35.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2604748441743257015" "False" "High" "IsMasterProtein" "Q6P1J9" "Parafibromin OS=Homo sapiens OX=9606 GN=CDC73 PE=1 SV=1" "0.000" "False" "10.210" "5" "3" "3" "3" "531" "60.5" "9.61" "10.03" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus" "other molecular function" "Pf05179, Pf16050" "79577" "ENSG00000134371" "CDC73" "A6NLZ8; B2RBR2; hsa:79577; Q6P1J9; Q6PK51; Q96A07; Q9H245; Q9H5L7" "Endoderm differentiation" "Hedgehog 'on' state; RNA Polymerase II Pre-transcription Events; E3 ubiquitin ligases ubiquitinate target proteins; Formation of the beta-catenin:TCF transactivating complex; Formation of RNA Pol II elongation complex" "7" "0" "1.028" "1.009" "0.917" "1.055" "1.035" "0.987" "0.962" "0.938" "5.151" "449.0" "461.5" "453.3" "411.6" "473.6" "464.5" "443.2" "432.1" "421.3" "2312.6" "" "" "" "" "" "" "" "" "" "" "403.7" "373.4" "410.0" "401.8" "390.8" "464.5" "331.9" "381.7" "377.0" "825.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146278248105171304" "False" "High" "IsMasterProtein" "Q6SJ93" "Serine protease FAM111B OS=Homo sapiens OX=9606 GN=FAM111B PE=1 SV=1" "0.000" "False" "10.200" "5" "5" "5" "4" "734" "84.6" "8.59" "15.47" "5" "protein metabolism;DNA metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf13365" "374393" "ENSG00000189057" "FAM111B" "B4E2G2; hsa:374393; Q6P661; Q6SJ93" "" "" "0" "0" "1.202" "1.171" "1.078" "1.097" "1.308" "1.118" "1.082" "1.293" "2.697" "287.2" "345.1" "336.2" "309.7" "315.1" "375.7" "321.0" "310.7" "371.3" "774.7" "" "" "" "" "" "" "" "" "" "" "258.2" "279.2" "304.1" "302.3" "260.1" "375.7" "240.4" "274.4" "332.2" "276.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2106052778808331693" "False" "High" "IsMasterProtein" "P62910" "Large ribosomal subunit protein eL32 OS=Homo sapiens OX=9606 GN=RPL32 PE=1 SV=2" "0.000" "False" "10.187" "26" "4" "4" "4" "135" "15.9" "11.33" "12.05" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01655" "6161" "ENSG00000144713" "RPL32" "B2R4Q3; hsa:6161; P02433; P62910" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.040" "1.001" "0.944" "1.107" "1.100" "1.123" "1.028" "1.029" "0.735" "427.5" "444.5" "427.8" "403.7" "473.3" "470.4" "480.2" "439.6" "439.7" "314.4" "" "" "" "" "" "" "" "" "" "" "384.4" "359.6" "386.9" "394.1" "390.5" "470.4" "359.6" "388.3" "393.5" "112.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5494004990375454112" "False" "High" "IsMasterProtein" "Q9ULH0" "Kinase D-interacting substrate of 220 kDa OS=Homo sapiens OX=9606 GN=KIDINS220 PE=1 SV=3" "0.000" "False" "10.171" "3" "4" "5" "4" "1771" "196.4" "6.62" "15.49" "4" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf07693, Pf12796" "57498" "ENSG00000134313" "KIDINS220" "A1L4N4; Q4VC08; Q6MZU2; Q9H889; Q9H9E4; Q9NT37; Q9UF42; Q9ULH0" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Neural crest cell migration in cancer" "RND2 GTPase cycle; RND1 GTPase cycle; ARMS-mediated activation" "5" "0" "1.157" "1.169" "1.028" "1.065" "1.093" "1.107" "1.019" "1.112" "1.016" "130.9" "151.5" "153.1" "134.6" "139.5" "143.2" "144.9" "133.5" "145.6" "133.1" "" "" "" "" "" "" "" "" "" "" "117.7" "122.6" "138.4" "131.3" "115.1" "143.2" "108.5" "117.9" "130.3" "47.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5885544299660582153" "False" "High" "IsMasterProtein" "P19971" "Thymidine phosphorylase OS=Homo sapiens OX=9606 GN=TYMP PE=1 SV=2" "0.000" "False" "10.133" "8" "3" "3" "3" "482" "49.9" "5.53" "10.28" "3" "cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol" "signal transduction activity or receptor binding;other molecular function" "Pf00591, Pf02885, Pf07831" "1890" "ENSG00000025708" "TYMP" "A8MW15; H9KVA0; hsa:1890; P19971; Q13390; Q8WVB7" "Fluoropyrimidine activity; Bladder cancer; Pyrimidine metabolism" "Pyrimidine salvage; Pyrimidine catabolism" "5" "0" "1.202" "0.994" "1.062" "1.203" "1.061" "1.052" "1.117" "1.091" "1.299" "92.6" "111.3" "92.1" "98.4" "111.4" "98.2" "97.4" "103.5" "101.1" "120.4" "" "" "" "" "" "" "" "" "" "" "83.3" "90.1" "83.3" "96.0" "91.9" "98.2" "72.9" "91.4" "90.4" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4559140579210949167" "False" "High" "IsMasterProtein" "P62917" "Large ribosomal subunit protein uL2 OS=Homo sapiens OX=9606 GN=RPL8 PE=1 SV=2" "0.000" "False" "10.078" "16" "4" "4" "4" "257" "28.0" "11.03" "9.17" "4" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00181, Pf03947" "6132" "ENSG00000161016" "RPL8" "A8K094; D3DWN2; hsa:6132; P25120; P62917; Q567Q7; Q969V7; Q9BWQ9" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); Protein hydroxylation" "15" "0" "0.946" "0.891" "0.889" "0.917" "0.845" "0.868" "0.889" "0.832" "0.677" "561.6" "531.0" "500.1" "499.2" "515.1" "474.6" "487.6" "499.0" "467.2" "380.2" "" "" "" "" "" "" "" "" "" "" "504.9" "429.7" "452.4" "487.3" "425.1" "474.6" "365.1" "440.7" "418.0" "135.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-632220125503920335" "False" "High" "IsMasterProtein" "Q6PII5" "Hydroxyacylglutathione hydrolase-like protein OS=Homo sapiens OX=9606 GN=HAGHL PE=1 SV=1" "0.000" "False" "10.058" "14" "4" "4" "4" "290" "31.5" "8.21" "11.71" "4" "" "" "other molecular function" "Pf00753" "84264" "ENSG00000103253" "HAGHL" "A6NCC4; D3DU64; hsa:84264; Q59FX8; Q6PII5; Q96BZ3; Q96NR5; Q96S11; Q9BT45" "Orexin receptor pathway" "" "1" "0" "1.099" "1.167" "1.145" "1.169" "1.279" "1.289" "1.080" "1.165" "1.085" "162.2" "178.3" "189.2" "185.6" "189.6" "207.4" "209.0" "175.1" "188.9" "176.0" "" "" "" "" "" "" "" "" "" "" "145.8" "144.2" "171.1" "181.2" "156.5" "207.4" "156.5" "154.6" "169.1" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-794247632168197847" "False" "High" "IsMasterProtein" "Q8NI37" "Protein phosphatase PTC7 homolog OS=Homo sapiens OX=9606 GN=PPTC7 PE=1 SV=1" "0.000" "False" "10.034" "13" "3" "3" "3" "304" "32.6" "5.19" "9.19" "3" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf07228" "160760" "ENSG00000196850" "PPTC7" "B3KWC5; hsa:160760; Q68DZ7; Q6UY82; Q8NI37" "" "" "0" "0" "0.976" "0.916" "0.933" "0.916" "0.879" "1.012" "0.840" "1.091" "1.033" "158.7" "154.9" "145.4" "148.0" "145.4" "139.6" "160.6" "133.3" "173.2" "164.0" "" "" "" "" "" "" "" "" "" "" "142.7" "125.3" "131.5" "144.5" "120.0" "139.6" "120.2" "117.8" "155.0" "58.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5673730343044781282" "False" "High" "IsMasterProtein" "Q96HS1" "Serine/threonine-protein phosphatase PGAM5, mitochondrial OS=Homo sapiens OX=9606 GN=PGAM5 PE=1 SV=2" "0.000" "False" "10.012" "16" "5" "5" "5" "289" "32.0" "8.68" "11.20" "5" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "enzyme regulator activity;other molecular function" "Pf00300" "192111" "ENSG00000247077" "PGAM5" "A9LN06; C9IZY7; hsa:192111; Q96HS1; Q96JB0" "NRF2-ARE regulation" "" "1" "0" "1.009" "1.025" "1.114" "1.238" "1.179" "1.070" "1.251" "1.086" "0.977" "54.8" "55.3" "56.2" "61.1" "67.9" "64.6" "58.7" "68.6" "59.5" "53.6" "" "" "" "" "" "" "" "" "" "" "49.3" "44.8" "50.8" "59.6" "56.0" "64.6" "43.9" "60.6" "53.3" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7694948017889393545" "False" "High" "IsMasterProtein" "Q8N490" "Probable hydrolase PNKD OS=Homo sapiens OX=9606 GN=PNKD PE=1 SV=2" "0.000" "False" "9.998" "9" "2" "2" "2" "385" "42.8" "9.09" "12.69" "2" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00753, Pf16123" "25953" "ENSG00000127838" "PNKD" "A8K1F2; hsa:25953; Q8N490; Q96A48; Q9BU26; Q9NSX4; Q9ULN6; Q9Y4T1" "Mitochondrial complex IV assembly" "" "1" "0" "1.198" "1.101" "0.915" "1.030" "0.982" "1.132" "1.046" "1.024" "0.930" "141.5" "169.6" "155.8" "129.5" "145.8" "138.9" "160.2" "148.0" "144.9" "131.6" "" "" "" "" "" "" "" "" "" "" "127.2" "137.2" "140.9" "126.4" "120.3" "138.9" "119.9" "130.7" "129.7" "47.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3562387644317083347" "False" "High" "IsMasterProtein" "Q8N3C0" "Activating signal cointegrator 1 complex subunit 3 OS=Homo sapiens OX=9606 GN=ASCC3 PE=1 SV=3" "0.000" "False" "9.992" "2" "4" "4" "4" "2202" "251.3" "7.09" "5.55" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00270, Pf00271, Pf02889" "10973" "ENSG00000112249" "ASCC3" "E7EW23; hsa:10973; O43738; Q4G1A0; Q5VTN2; Q8N3C0; Q9H1I9; Q9H5A2; Q9NTR0" "Mesodermal commitment pathway; VEGFA-VEGFR2 signaling" "ALKBH3 mediated reversal of alkylation damage" "3" "0" "1.083" "0.921" "1.002" "1.162" "0.949" "1.078" "0.960" "1.014" "1.223" "245.5" "265.9" "226.1" "245.9" "285.1" "232.9" "264.6" "235.7" "248.8" "300.2" "" "" "" "" "" "" "" "" "" "" "220.7" "215.2" "204.5" "240.1" "235.3" "232.9" "198.2" "208.2" "222.6" "107.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7523601130490084284" "False" "High" "IsMasterProtein" "Q9BX63" "Fanconi anemia group J protein OS=Homo sapiens OX=9606 GN=BRIP1 PE=1 SV=2" "0.000" "False" "9.979" "4" "5" "5" "5" "1249" "140.8" "6.92" "9.88" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06733, Pf13307" "83990" "ENSG00000136492" "BRIP1" "A0A024QZ45; hsa:83990; Q3MJE2; Q8NCI5; Q9BX63" "DNA repair pathways, full network" "Processing of DNA double-strand break ends; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51; Cytosolic iron-sulfur cluster assembly" "16" "0" "1.155" "1.179" "1.083" "1.027" "1.204" "1.011" "0.956" "1.172" "1.236" "120.2" "138.9" "141.7" "130.2" "123.4" "144.7" "121.5" "114.9" "140.9" "148.5" "" "" "" "" "" "" "" "" "" "" "108.1" "112.4" "128.2" "127.1" "101.9" "144.7" "91.0" "101.5" "126.1" "53.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1630432664316486602" "False" "High" "IsMasterProtein" "Q16563" "Synaptophysin-like protein 1 OS=Homo sapiens OX=9606 GN=SYPL1 PE=1 SV=1" "0.000" "False" "9.956" "7" "2" "4" "2" "259" "28.5" "8.43" "14.05" "2" "cell-cell signaling" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf01284" "6856" "ENSG00000008282" "SYPL1" "A4D0R2; hsa:6856; Q16563; Q96AR8" "" "" "0" "0" "0.941" "0.920" "1.041" "0.874" "0.755" "0.848" "0.993" "1.005" "0.787" "192.8" "181.4" "177.4" "200.7" "168.4" "145.5" "163.5" "191.4" "193.8" "151.8" "" "" "" "" "" "" "" "" "" "" "173.3" "146.8" "160.4" "195.9" "139.0" "145.5" "122.4" "169.1" "173.4" "54.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3050786431982256186" "False" "High" "IsMasterProtein" "Q53ET0" "CREB-regulated transcription coactivator 2 OS=Homo sapiens OX=9606 GN=CRTC2 PE=1 SV=2" "0.000" "False" "9.944" "5" "3" "3" "3" "693" "73.3" "7.11" "10.39" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12884, Pf12885, Pf12886" "200186" "ENSG00000160741" "CRTC2" "hsa:200186; Q53ET0; Q6UUV8; Q7Z3X7; Q8N332" "AMP-activated protein kinase signaling; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Circadian Clock; Heme signaling; Transcriptional activation of mitochondrial biogenesis" "5" "0" "1.097" "1.000" "1.109" "1.029" "1.023" "1.023" "0.979" "0.908" "1.315" "159.0" "174.5" "159.0" "176.3" "163.6" "162.6" "162.7" "155.7" "144.4" "209.1" "" "" "" "" "" "" "" "" "" "" "143.0" "141.2" "143.8" "172.1" "135.0" "162.6" "121.8" "137.5" "129.2" "74.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7551679411334968012" "False" "High" "IsMasterProtein" "Q15649" "Zinc finger HIT domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZNHIT3 PE=1 SV=2" "0.000" "False" "9.941" "19" "3" "4" "3" "155" "17.6" "5.67" "12.98" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438, Pf21373" "9326" "ENSG00000273611; ENSG00000278574" "ZNHIT3" "A8K493; hsa:9326; K7EQP1; Q15649; Q8WVJ3" "17q12 copy number variation syndrome" "" "1" "0" "0.969" "1.007" "0.946" "0.944" "1.136" "1.004" "1.028" "1.100" "0.746" "289.8" "280.7" "291.7" "274.1" "273.7" "329.3" "290.9" "297.9" "318.6" "216.3" "" "" "" "" "" "" "" "" "" "" "260.5" "227.1" "263.8" "267.5" "225.8" "329.3" "217.8" "263.2" "285.1" "77.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8996103182095070186" "False" "High" "IsMasterProtein" "Q9UBF6" "RING-box protein 2 OS=Homo sapiens OX=9606 GN=RNF7 PE=1 SV=1" "0.000" "False" "9.937" "19" "2" "3" "2" "113" "12.7" "5.44" "9.92" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9616" "ENSG00000114125" "RNF7" "A8K1H9; A8MTB5; C9JYL3; D3DNF7; D3DNF8; hsa:9616; Q9BXN8; Q9UBF6; Q9Y5M7" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Modulators of TCR signaling and T cell activation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Inactivation of CSF3 (G-CSF) signaling" "5" "0" "0.923" "1.024" "0.811" "0.981" "0.966" "0.929" "0.895" "0.918" "0.814" "375.5" "346.5" "384.7" "304.5" "368.5" "362.8" "348.8" "336.1" "344.8" "305.7" "" "" "" "" "" "" "" "" "" "" "337.7" "280.4" "348.0" "297.3" "304.1" "362.8" "261.2" "296.9" "308.5" "109.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3667791429140774240" "False" "High" "IsMasterProtein" "Q9NUM4" "Transmembrane protein 106B OS=Homo sapiens OX=9606 GN=TMEM106B PE=1 SV=2" "0.000" "False" "9.934" "11" "3" "4" "3" "274" "31.1" "6.99" "12.34" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf07092, Pf21002" "54664" "ENSG00000106460" "TMEM106B" "A4D108; hsa:54664; Q53FL9; Q8N4L0; Q9NUM4" "" "" "0" "0" "0.905" "0.993" "0.959" "1.023" "0.874" "0.993" "0.956" "1.017" "0.753" "551.8" "499.4" "548.1" "529.4" "564.7" "482.1" "547.9" "527.3" "561.1" "415.4" "" "" "" "" "" "" "" "" "" "" "496.1" "404.1" "495.8" "516.8" "466.0" "482.1" "410.2" "465.8" "502.0" "148.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3577939540596101206" "False" "High" "IsMasterProtein" "Q96HD9" "N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) OS=Homo sapiens OX=9606 GN=ACY3 PE=1 SV=1" "0.000" "False" "9.933" "9" "3" "5" "3" "319" "35.2" "5.90" "11.05" "3" "" "plasma membrane;other membranes;cytosol" "other molecular function" "Pf04952" "91703" "ENSG00000132744" "ACY3" "hsa:91703; Q96HD9" "" "Aflatoxin activation and detoxification" "1" "0" "1.036" "1.028" "1.005" "0.946" "0.940" "0.970" "0.916" "0.984" "1.015" "418.6" "433.8" "430.3" "420.7" "396.0" "393.4" "406.2" "383.5" "411.9" "424.8" "" "" "" "" "" "" "" "" "" "" "376.3" "351.0" "389.3" "410.7" "326.8" "393.4" "304.1" "338.7" "368.6" "151.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5532821643516687408" "False" "High" "IsMasterProtein" "Q6P158" "Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens OX=9606 GN=DHX57 PE=1 SV=2" "0.000" "False" "9.931" "2" "3" "5" "2" "1386" "155.5" "7.71" "13.13" "3" "" "" "other molecular function" "Pf00270, Pf00271, Pf04408, Pf05773, Pf07717, Pf18044, Pf21010" "90957" "ENSG00000163214" "DHX57" "A2RRC7; hsa:90957; Q53SI4; Q6P158; Q6P9G1; Q7Z6H3; Q8NG17; Q96M33" "" "" "0" "0" "1.095" "0.980" "0.943" "1.034" "1.034" "1.046" "1.057" "0.987" "1.037" "187.2" "204.9" "183.5" "176.5" "193.5" "193.6" "195.8" "197.8" "184.7" "194.2" "" "" "" "" "" "" "" "" "" "" "168.3" "165.8" "166.0" "172.3" "159.7" "193.6" "146.6" "174.7" "165.3" "69.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7445573923015050179" "False" "High" "IsMasterProtein" "Q9BYC8" "Large ribosomal subunit protein bL32m OS=Homo sapiens OX=9606 GN=MRPL32 PE=1 SV=1" "0.000" "False" "9.928" "24" "3" "3" "3" "188" "21.4" "9.73" "13.42" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01783" "64983" "ENSG00000106591" "MRPL32" "hsa:64983; Q96Q68; Q9BYC8; Q9P098" "" "Mitochondrial protein degradation; Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "4" "0" "0.889" "1.005" "0.897" "0.933" "0.952" "0.838" "0.995" "0.973" "0.947" "282.2" "251.0" "283.7" "253.2" "263.4" "268.6" "236.5" "280.8" "274.5" "267.1" "" "" "" "" "" "" "" "" "" "" "253.7" "203.1" "256.6" "247.1" "217.3" "268.6" "177.1" "248.1" "245.6" "95.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8605151959694531472" "False" "High" "IsMasterProtein" "Q13888" "General transcription factor IIH subunit 2 OS=Homo sapiens OX=9606 GN=GTF2H2 PE=1 SV=1" "0.000" "False" "9.927" "7" "3" "3" "3" "395" "44.4" "6.76" "9.88" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus" "other molecular function" "Pf04056, Pf07975" "2966" "ENSG00000145736; ENSG00000275045; ENSG00000276910" "GTF2H2" "hsa:2966; Q13888; Q15570; Q15571; Q9BS41" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "0.959" "1.105" "0.917" "1.174" "1.084" "0.984" "1.038" "1.107" "1.334" "283.6" "271.9" "313.5" "260.1" "333.0" "307.4" "279.1" "294.5" "313.9" "378.4" "" "" "" "" "" "" "" "" "" "" "255.0" "220.0" "283.5" "253.9" "274.8" "307.4" "209.0" "260.1" "280.9" "135.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580559568770530829" "False" "High" "IsMasterProtein" "Q14135" "Transcription cofactor vestigial-like protein 4 OS=Homo sapiens OX=9606 GN=VGLL4 PE=1 SV=4" "0.000" "False" "9.924" "12" "3" "4" "3" "290" "30.9" "8.22" "12.72" "3" "other biological processes" "nucleus" "other molecular function" "Pf15245" "9686" "ENSG00000144560" "VGLL4" "B4DTS7; hsa:9686; J3KN68; Q14135; Q7L5V0; Q9BQ78" "Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "2" "0" "0.955" "0.835" "0.807" "0.924" "0.885" "0.888" "0.831" "0.778" "0.679" "173.9" "166.1" "145.1" "140.3" "160.6" "153.8" "154.5" "144.6" "135.4" "118.1" "" "" "" "" "" "" "" "" "" "" "156.4" "134.4" "131.3" "136.9" "132.5" "153.8" "115.7" "127.7" "121.1" "42.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177131133338512997" "False" "High" "IsMasterProtein" "Q8IXM3" "Large ribosomal subunit protein mL41 OS=Homo sapiens OX=9606 GN=MRPL41 PE=1 SV=1" "0.000" "False" "9.912" "26" "3" "3" "3" "137" "15.4" "9.57" "11.96" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;other cell component" "other molecular function" "Pf09809" "64975" "ENSG00000182154" "MRPL41" "hsa:64975; Q8IXM3; Q96Q49" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.075" "0.903" "1.086" "0.858" "0.866" "0.885" "0.943" "0.983" "1.074" "205.4" "220.7" "185.4" "223.0" "176.2" "177.9" "181.8" "193.7" "201.8" "220.5" "" "" "" "" "" "" "" "" "" "" "184.6" "178.6" "167.7" "217.6" "145.4" "177.9" "136.1" "171.1" "180.6" "78.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5033542782093602446" "False" "High" "IsMasterProtein" "P05062" "Fructose-bisphosphate aldolase B OS=Homo sapiens OX=9606 GN=ALDOB PE=1 SV=2" "0.000" "False" "9.911" "8" "3" "15" "1" "364" "39.4" "7.87" "42.69" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf00274" "229" "ENSG00000136872" "ALDOB" "hsa:229; P05062; Q13741; Q13742; Q5T7D6" "Clear cell renal cell carcinoma pathways; Metabolic reprogramming in colon cancer; Disorders of fructose metabolism; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders; Polyol pathway" "Glycolysis; Gluconeogenesis; Fructose catabolism; Hereditary fructose intolerance" "10" "0" "0.734" "0.773" "0.349" "0.857" "0.849" "0.784" "0.498" "0.840" "0.730" "23.3" "17.1" "18.0" "8.1" "20.0" "19.8" "18.3" "11.6" "19.6" "17.0" "" "" "" "" "" "" "" "" "" "" "21.0" "13.8" "16.3" "7.9" "16.5" "19.8" "13.7" "10.3" "17.5" "6.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4589433783542351991" "False" "High" "IsMasterProtein" "Q9NVU0" "DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens OX=9606 GN=POLR3E PE=1 SV=1" "0.000" "False" "9.881" "5" "3" "4" "3" "708" "79.8" "6.47" "14.37" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus" "" "Pf04801, Pf19725" "55718" "ENSG00000058600; ENSG00000284282" "POLR3E" "B4DL24; B4DUP6; H3BT11; hsa:55718; Q9BWF7; Q9H8W8; Q9H907; Q9NVU0; Q9P276" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.960" "0.696" "0.965" "0.837" "0.878" "1.039" "0.835" "0.781" "1.329" "45.3" "43.5" "31.5" "43.7" "37.9" "39.8" "47.0" "37.8" "35.4" "60.2" "" "" "" "" "" "" "" "" "" "" "40.7" "35.2" "28.5" "42.6" "31.3" "39.8" "35.2" "33.4" "31.6" "21.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817415269467879151" "False" "High" "IsMasterProtein" "P16435" "NADPH--cytochrome P450 reductase OS=Homo sapiens OX=9606 GN=POR PE=1 SV=2" "0.000" "False" "9.875" "5" "4" "5" "4" "677" "76.6" "5.58" "17.00" "4" "other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00175, Pf00258, Pf00667" "5447" "ENSG00000127948" "POR" "P16435; Q16455; Q197M5; Q8N181; Q9H3M8; Q9UDT3" "Oxidation by cytochrome P450; Ferroptosis; 7q11.23 distal copy number variation" "Cytochrome P450 - arranged by substrate type" "4" "0" "0.995" "1.091" "1.064" "1.003" "0.987" "1.011" "1.032" "1.041" "0.866" "568.2" "565.1" "619.9" "604.7" "570.1" "560.9" "574.5" "586.3" "591.4" "491.8" "" "" "" "" "" "" "" "" "" "" "510.9" "457.3" "560.7" "590.3" "470.5" "560.9" "430.2" "517.9" "529.2" "175.6" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4950317330528062097" "False" "High" "IsMasterProtein" "Q92466" "DNA damage-binding protein 2 OS=Homo sapiens OX=9606 GN=DDB2 PE=1 SV=1" "0.000" "False" "9.864" "7" "3" "3" "3" "427" "47.8" "9.47" "10.70" "3" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400" "1643" "ENSG00000134574" "DDB2" "B2R875; hsa:1643; Q76E54; Q76E55; Q76E56; Q76E57; Q92466" "miRNA regulation of DNA damage response; miRNA regulation of p53 pathway in prostate cancer; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; Small cell lung cancer; Hepatitis B infection; Melanoma; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum ; DNA damage response" "Formation of Incision Complex in GG-NER; Dual Incision in GG-NER; Ub-specific processing proteases; Neddylation; TP53 Regulates Transcription of DNA Repair Genes; DNA Damage Recognition in GG-NER" "21" "0" "1.037" "1.007" "0.902" "1.082" "1.106" "1.086" "0.863" "1.032" "0.924" "369.1" "382.8" "371.8" "333.0" "399.5" "408.3" "400.8" "318.6" "380.8" "341.1" "" "" "" "" "" "" "" "" "" "" "331.9" "309.7" "336.3" "325.0" "329.7" "408.3" "300.1" "281.4" "340.8" "121.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4479122024934742870" "False" "High" "IsMasterProtein" "Q92934" "Bcl2-associated agonist of cell death OS=Homo sapiens OX=9606 GN=BAD PE=1 SV=3" "0.000" "False" "9.841" "14" "2" "3" "2" "168" "18.4" "7.15" "12.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf10514" "572" "ENSG00000002330" "BAD" "hsa:572; O14803; Q6FH21; Q92934" "Leptin signaling pathway; IL-7 signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Ras signaling; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Alzheimer's disease; Acute myeloid leukemia; ErbB signaling pathway; DNA damage response (only ATM dependent)" "NRAGE signals death through JNK; Constitutive Signaling by AKT1 E17K in Cancer; AKT phosphorylates targets in the cytosol; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Activation of BAD and translocation to mitochondria" "42" "0" "0.913" "1.043" "0.965" "0.937" "1.175" "1.003" "0.936" "1.015" "0.754" "207.9" "189.8" "216.9" "200.6" "194.8" "244.3" "208.6" "194.5" "210.9" "156.7" "" "" "" "" "" "" "" "" "" "" "186.9" "153.5" "196.2" "195.8" "160.7" "244.3" "156.2" "171.8" "188.7" "55.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5352136499893616615" "False" "High" "IsMasterProtein" "O95219" "Sorting nexin-4 OS=Homo sapiens OX=9606 GN=SNX4 PE=1 SV=1" "0.000" "False" "9.839" "7" "3" "4" "3" "450" "51.9" "5.99" "13.16" "3" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00787" "8723" "ENSG00000114520" "SNX4" "B3KMH0; B4DQV4; D3DNA3; hsa:8723; O95219" "" "" "0" "0" "0.938" "1.011" "0.980" "1.032" "0.988" "1.015" "0.947" "1.027" "1.594" "306.5" "287.6" "309.8" "300.4" "316.4" "302.7" "311.2" "290.4" "314.8" "488.7" "" "" "" "" "" "" "" "" "" "" "275.6" "232.7" "280.3" "293.2" "261.1" "302.7" "233.0" "256.5" "281.7" "174.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294747431044223143" "False" "High" "IsMasterProtein" "Q9UBN7" "Histone deacetylase 6 OS=Homo sapiens OX=9606 GN=HDAC6 PE=1 SV=2" "0.000" "False" "9.830" "2" "3" "4" "3" "1215" "131.3" "5.30" "12.32" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00850, Pf02148" "10013" "ENSG00000094631" "HDAC6" "hsa:10013; O94975; Q6NT75; Q7L3E5; Q96CY0; Q9UBN7" "Neural crest differentiation; Ectoderm differentiation; Ectoderm differentiation; Ethanol effects on histone modifications; 7q11.23 copy number variation syndrome; HDAC6 interactions in the central nervous system" "Late endosomal microautophagy; Cilium Assembly; Aggrephagy; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Transcriptional regulation by RUNX2; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX2 regulates osteoblast differentiation; Chaperone Mediated Autophagy; HSF1 activation" "17" "0" "1.065" "1.059" "1.006" "1.047" "1.081" "1.135" "0.977" "0.993" "1.148" "252.5" "268.8" "267.5" "254.1" "264.4" "272.8" "286.6" "246.8" "250.6" "290.0" "" "" "" "" "" "" "" "" "" "" "227.0" "217.5" "242.0" "248.1" "218.2" "272.8" "214.6" "218.0" "224.2" "103.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1889063708723088162" "False" "High" "IsMasterProtein" "O14772" "Fucose-1-phosphate guanylyltransferase OS=Homo sapiens OX=9606 GN=FPGT PE=1 SV=3" "0.000" "False" "9.811" "8" "4" "4" "4" "607" "68.0" "6.87" "6.05" "4" "other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf07959" "8790" "ENSG00000254685" "FPGT" "A0A0A0MRP2; A6NMH3; B4DRX2; B4E2Y7; E9PNQ2; hsa:8790; O14772; Q8N5J7" "" "GDP-fucose biosynthesis" "1" "0" "0.955" "1.000" "0.876" "1.037" "0.808" "0.911" "1.001" "0.935" "0.596" "156.0" "149.0" "156.1" "136.7" "161.7" "126.0" "142.2" "156.2" "145.9" "93.0" "" "" "" "" "" "" "" "" "" "" "140.3" "120.6" "141.2" "133.4" "133.5" "126.0" "106.5" "138.0" "130.5" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4842637441270179392" "False" "High" "IsMasterProtein" "Q9BU76" "Multiple myeloma tumor-associated protein 2 OS=Homo sapiens OX=9606 GN=MMTAG2 PE=1 SV=1" "0.000" "False" "9.808" "13" "3" "3" "3" "263" "29.4" "10.02" "9.72" "3" "" "non-structural extracellular;other cell component" "" "Pf10159" "79169" "ENSG00000143793" "MMTAG2" "hsa:79169; Q6P5Y0; Q6ZTZ6; Q6ZWA6; Q8IZH3; Q9BU76" "" "Neutrophil degranulation" "1" "0" "1.452" "1.025" "1.196" "1.193" "1.622" "1.032" "1.070" "1.148" "0.826" "25.1" "36.4" "25.7" "30.0" "29.9" "40.6" "25.9" "26.8" "28.8" "20.7" "" "" "" "" "" "" "" "" "" "" "22.5" "29.4" "23.2" "29.3" "24.7" "40.6" "19.4" "23.7" "25.7" "7.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3086307340332827349" "False" "High" "IsMasterProtein" "Q9UL45" "Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Homo sapiens OX=9606 GN=BLOC1S6 PE=1 SV=1" "0.000" "False" "9.794" "20" "2" "2" "2" "172" "19.7" "6.40" "13.41" "2" "cell-cell signaling;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf14712" "26258" "ENSG00000104164" "BLOC1S6" "hsa:26258; Q9UL45" "Alstrom syndrome" "Golgi Associated Vesicle Biogenesis" "2" "0" "0.894" "0.967" "0.901" "0.968" "0.955" "0.924" "1.022" "0.983" "0.766" "258.4" "231.0" "249.9" "232.9" "250.2" "246.9" "238.8" "264.2" "253.9" "197.9" "" "" "" "" "" "" "" "" "" "" "232.3" "186.9" "226.1" "227.4" "206.5" "246.9" "178.8" "233.3" "227.2" "70.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288678854882700202" "False" "High" "IsMasterProtein" "Q7Z3C6" "Autophagy-related protein 9A OS=Homo sapiens OX=9606 GN=ATG9A PE=1 SV=3" "0.000" "False" "9.733" "4" "3" "5" "3" "839" "94.4" "6.67" "8.81" "3" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity" "Pf04109" "79065" "ENSG00000198925" "ATG9A" "hsa:79065; Q3ZAQ6; Q6P0N7; Q7Z317; Q7Z320; Q7Z3C6; Q8NDK6; Q8WU65; Q9BVL5; Q9H6L1; Q9HAG7" "Autophagy; Primary ovarian insufficiency" "Macroautophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2807670351825780389" "False" "High" "IsMasterProtein" "P0DI82" "Trafficking protein particle complex subunit 2B OS=Homo sapiens OX=9606 GN=TRAPPC2B PE=1 SV=1" "0.000" "False" "9.725" "16" "2" "3" "2" "140" "16.4" "6.52" "10.89" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04628" "6399" "ENSG00000256060" "TRAPPC2B" "A6NEG0; hsa:6399; O14582; P0DI82; Q9HD16" "" "" "0" "0" "0.851" "0.994" "0.930" "1.011" "1.083" "1.162" "1.002" "0.924" "1.317" "46.9" "39.9" "46.6" "43.7" "47.5" "50.8" "54.5" "47.0" "43.4" "61.8" "" "" "" "" "" "" "" "" "" "" "42.2" "32.3" "42.2" "42.6" "39.2" "50.8" "40.8" "41.5" "38.8" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3327370381573557729" "False" "High" "IsMasterProtein" "Q99611" "Selenide, water dikinase 2 OS=Homo sapiens OX=9606 GN=SEPHS2 PE=1 SV=3" "0.000" "False" "9.719" "12" "4" "4" "3" "448" "47.3" "5.88" "12.02" "4" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00586, Pf02769" "22928" "ENSG00000179918" "SEPHS2" "hsa:22928; Q99611; Q9BUQ2" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "Selenocysteine synthesis" "3" "0" "0.800" "0.798" "1.143" "0.983" "0.955" "1.002" "0.940" "0.982" "1.130" "74.3" "59.5" "59.3" "84.9" "73.1" "71.0" "74.5" "69.9" "73.0" "84.0" "" "" "" "" "" "" "" "" "" "" "66.8" "48.1" "53.7" "82.9" "60.3" "71.0" "55.7" "61.7" "65.3" "30.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6163739139500016116" "False" "High" "IsMasterProtein" "Q9BSQ5" "Cerebral cavernous malformations 2 protein OS=Homo sapiens OX=9606 GN=CCM2 PE=1 SV=1" "0.000" "False" "9.718" "7" "3" "3" "3" "444" "48.8" "5.54" "9.26" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;other cell component" "" "Pf16545" "83605" "ENSG00000136280" "CCM2" "A4D2L4; B3KUV0; D3DVL4; E9PDJ3; F5H0E1; F5H551; hsa:83605; Q71RE5; Q8TAT4; Q9BSQ5" "" "" "0" "0" "0.961" "0.903" "0.997" "0.931" "0.952" "1.002" "0.949" "0.988" "1.114" "264.1" "253.8" "238.4" "263.3" "245.8" "251.4" "264.7" "250.6" "260.9" "294.2" "" "" "" "" "" "" "" "" "" "" "237.5" "205.4" "215.6" "257.0" "202.8" "251.4" "198.2" "221.4" "233.5" "105.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5299456138050834551" "False" "High" "IsMasterProtein" "O00115" "Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2" "0.000" "False" "9.716" "8" "3" "3" "3" "360" "39.6" "8.05" "11.12" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf03265" "1777" "ENSG00000105612" "DNASE2" "B2RD06; B7Z4K6; hsa:1777; O00115; O43910" "" "Lysosome Vesicle Biogenesis" "1" "0" "0.908" "0.981" "1.042" "1.044" "1.081" "1.055" "1.122" "0.965" "0.941" "435.9" "395.8" "427.5" "454.4" "455.0" "471.2" "460.0" "489.2" "420.9" "410.4" "" "" "" "" "" "" "" "" "" "" "392.0" "320.3" "386.7" "443.5" "375.5" "471.2" "344.4" "432.1" "376.6" "146.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429984818239481220" "False" "High" "IsMasterProtein" "O60488" "Long-chain-fatty-acid--CoA ligase 4 OS=Homo sapiens OX=9606 GN=ACSL4 PE=1 SV=2" "0.000" "False" "9.687" "7" "4" "4" "4" "711" "79.1" "8.38" "14.09" "4" "other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00501" "2182" "ENSG00000068366" "ACSL4" "D3DUY2; hsa:2182; O60488; O60848; O60849; Q5JWV8" "Fatty acid beta-oxidation; Fatty acid biosynthesis; Mitochondrial long chain fatty acid beta-oxidation; PPAR signaling pathway; Ferroptosis; Thermogenesis; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Omega-3 / omega-6 fatty acid synthesis; Omega-9 fatty acid synthesis; Fatty acid transporters; Mitochondrial fatty acid oxidation disorders" "Synthesis of very long-chain fatty acyl-CoAs; Intracellular metabolism of fatty acids regulates insulin secretion" "13" "0" "0.971" "0.899" "0.871" "0.911" "1.002" "0.941" "1.005" "1.097" "1.713" "215.9" "209.7" "194.1" "188.0" "196.6" "216.3" "203.2" "217.0" "236.8" "369.9" "" "" "" "" "" "" "" "" "" "" "194.1" "169.7" "175.6" "183.6" "162.2" "216.3" "152.2" "191.7" "211.9" "132.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2415988570574177896" "False" "High" "IsMasterProtein" "P13196" "5-aminolevulinate synthase, non-specific, mitochondrial OS=Homo sapiens OX=9606 GN=ALAS1 PE=1 SV=2" "0.000" "False" "9.654" "5" "4" "4" "4" "640" "70.5" "8.46" "11.29" "4" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf00155, Pf09029" "211" "ENSG00000023330" "ALAS1" "hsa:211; P13196" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Hemesynthesis defects and porphyrias; Heme biosynthesis" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation; PPARA activates gene expression; Heme biosynthesis" "8" "0" "1.016" "1.007" "0.963" "1.031" "1.020" "0.948" "0.920" "1.006" "1.325" "130.7" "132.7" "131.6" "125.8" "134.8" "133.3" "123.9" "120.3" "131.4" "173.1" "" "" "" "" "" "" "" "" "" "" "117.5" "107.4" "119.1" "122.8" "111.2" "133.3" "92.8" "106.2" "117.6" "61.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2291665734159650582" "False" "High" "IsMasterProtein" "P62310" "U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens OX=9606 GN=LSM3 PE=1 SV=2" "0.000" "False" "9.649" "20" "2" "9" "2" "102" "11.8" "4.70" "26.28" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "27258" "ENSG00000170860" "LSM3" "hsa:27258; P62310; Q6IAH0; Q9Y4Z1" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "0.922" "0.956" "0.959" "1.026" "0.951" "1.019" "1.024" "0.935" "0.790" "638.6" "588.4" "610.5" "612.2" "655.4" "607.0" "651.0" "653.9" "597.1" "504.3" "" "" "" "" "" "" "" "" "" "" "574.1" "476.2" "552.2" "597.6" "540.8" "607.0" "487.4" "577.5" "534.3" "180.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6209502681101224333" "False" "High" "IsMasterProtein" "Q9NV96" "Cell cycle control protein 50A OS=Homo sapiens OX=9606 GN=TMEM30A PE=1 SV=1" "0.000" "False" "9.639" "10" "3" "4" "3" "361" "40.7" "8.59" "15.66" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03381" "55754" "ENSG00000112697" "TMEM30A" "A8K9V8; E1P539; hsa:55754; Q658Z3; Q96H09; Q9NSL9; Q9NV96" "" "Neutrophil degranulation" "1" "0" "0.995" "0.993" "1.056" "0.974" "0.959" "1.017" "0.993" "0.962" "0.974" "418.1" "416.0" "415.1" "441.7" "407.4" "401.1" "425.4" "415.0" "402.1" "407.4" "" "" "" "" "" "" "" "" "" "" "375.9" "336.6" "375.5" "431.1" "336.2" "401.1" "318.5" "366.6" "359.8" "145.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6360176631635833399" "False" "High" "IsMasterProtein" "P25054" "Adenomatous polyposis coli protein OS=Homo sapiens OX=9606 GN=APC PE=1 SV=2" "0.000" "False" "9.638" "2" "4" "4" "4" "2843" "311.5" "7.80" "8.72" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00514, Pf05923, Pf05924, Pf05937, Pf05956, Pf05972, Pf11414, Pf16629, Pf16630, Pf16633, Pf16634, Pf16635, Pf16636, Pf16689, Pf18797" "324" "ENSG00000134982" "APC" "B7Z2B6; D3DT03; hsa:324; P25054; Q15162; Q15163; Q93042" "Microtubule cytoskeleton regulation; Alzheimer's disease and miRNA effects; Gastric cancer network 1; Brain-derived neurotrophic factor (BDNF) signaling pathway; Endoderm differentiation; Extracellular vesicle-mediated signaling in recipient cells; Copper homeostasis; Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Physico-chemical features and toxicity-associated pathways; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; Regulation of sister chromatid separation at the metaphase-anaphase transition; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Ciliary landscape; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Regulation of actin cytoskeleton; Cohesin complex - Cornelia de Lange syndrome; Alzheimer's disease; 2q21.1 copy number variation syndrome; HDAC6 interactions in the central nervous system; DNA damage response (only ATM dependent)" "Deactivation of the beta-catenin transactivating complex; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Beta-catenin phosphorylation cascade; Signaling by GSK3beta mutants; CTNNB1 S33 mutants aren't phosphorylated; CTNNB1 S37 mutants aren't phosphorylated; CTNNB1 S45 mutants aren't phosphorylated; CTNNB1 T41 mutants aren't phosphorylated; APC truncation mutants have impaired AXIN binding; AXIN missense mutants destabilize the destruction complex; Truncations of AMER1 destabilize the destruction complex; Ovarian tumor domain proteases; Apoptotic cleavage of cellular proteins; APC truncation mutants are not K63 polyubiquitinated" "45" "0" "0.888" "1.037" "1.002" "0.975" "0.963" "0.970" "0.999" "0.984" "1.012" "164.1" "145.8" "170.2" "164.5" "160.0" "158.0" "159.3" "164.0" "161.5" "166.1" "" "" "" "" "" "" "" "" "" "" "147.6" "118.0" "153.9" "160.6" "132.0" "158.0" "119.3" "144.9" "144.5" "59.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-501406145012788137" "False" "High" "IsMasterProtein" "Q9H2K0" "Translation initiation factor IF-3, mitochondrial OS=Homo sapiens OX=9606 GN=MTIF3 PE=1 SV=4" "0.000" "False" "9.626" "14" "4" "4" "4" "278" "31.7" "9.69" "10.61" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "translation activity;nucleic acid binding activity" "Pf05198" "219402" "ENSG00000122033" "MTIF3" "hsa:219402; Q05BL8; Q5W0V0; Q86X68; Q9H2K0" "" "Mitochondrial translation initiation" "1" "0" "0.938" "0.764" "0.967" "1.170" "1.137" "1.283" "0.997" "1.149" "0.714" "63.9" "59.9" "48.8" "61.8" "74.7" "72.6" "82.0" "63.7" "73.4" "45.6" "" "" "" "" "" "" "" "" "" "" "57.4" "48.5" "44.1" "60.3" "61.7" "72.6" "61.4" "56.3" "65.7" "16.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8230923864296422238" "False" "High" "IsMasterProtein" "Q9Y303" "N-acetylglucosamine-6-phosphate deacetylase OS=Homo sapiens OX=9606 GN=AMDHD2 PE=1 SV=2" "0.000" "False" "9.604" "7" "3" "3" "3" "409" "43.7" "6.70" "11.43" "3" "other metabolic processes" "cytosol" "other molecular function" "Pf01979" "51005" "ENSG00000162066" "AMDHD2" "B4DL77; hsa:51005; Q8WV54; Q9Y303" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "1.142" "1.111" "0.894" "1.141" "1.097" "1.014" "0.982" "1.047" "0.891" "141.7" "161.8" "157.5" "126.6" "161.7" "155.5" "143.7" "139.2" "148.3" "126.2" "" "" "" "" "" "" "" "" "" "" "127.4" "130.9" "142.4" "123.6" "133.4" "155.5" "107.6" "122.9" "132.7" "45.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3469451344216092879" "False" "High" "IsMasterProtein" "O14810" "Complexin-1 OS=Homo sapiens OX=9606 GN=CPLX1 PE=1 SV=1" "0.000" "False" "9.576" "25" "2" "3" "2" "134" "15.0" "4.97" "9.24" "2" "cell-cell signaling;transport;other biological processes" "other membranes;cytosol;other cell component" "transporter activity;other molecular function" "Pf05835" "10815" "ENSG00000168993" "CPLX1" "A6NI80; B2R4R5; D3DVN3; F1T0G1; hsa:10815; O14810" "Synaptic vesicle pathway" "Glutamate Neurotransmitter Release Cycle; Serotonin Neurotransmitter Release Cycle; Norepinephrine Neurotransmitter Release Cycle; Dopamine Neurotransmitter Release Cycle; Acetylcholine Neurotransmitter Release Cycle; GABA synthesis, release, reuptake and degradation" "7" "0" "1.020" "0.845" "0.875" "1.091" "1.205" "1.246" "0.949" "1.033" "1.184" "56.8" "57.9" "48.0" "49.7" "61.9" "68.4" "70.7" "53.9" "58.6" "67.2" "" "" "" "" "" "" "" "" "" "" "51.0" "46.8" "43.4" "48.5" "51.1" "68.4" "52.9" "47.6" "52.5" "24.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4077783620514139312" "False" "High" "IsMasterProtein" "Q15650" "Activating signal cointegrator 1 OS=Homo sapiens OX=9606 GN=TRIP4 PE=1 SV=4" "0.000" "False" "9.560" "8" "4" "4" "4" "581" "66.1" "7.85" "13.11" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf04266, Pf06221" "9325" "ENSG00000103671" "TRIP4" "B2RAS0; hsa:9325; Q15650; Q96ED7; Q9UKH0" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.930" "1.058" "0.971" "0.905" "0.924" "1.114" "0.951" "1.028" "0.906" "158.5" "147.3" "167.7" "153.8" "143.5" "146.4" "176.6" "150.7" "163.0" "143.6" "" "" "" "" "" "" "" "" "" "" "142.5" "119.2" "151.7" "150.2" "118.4" "146.4" "132.2" "133.1" "145.8" "51.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4959898328745925415" "False" "High" "IsMasterProtein" "Q6IN84" "rRNA methyltransferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=MRM1 PE=1 SV=1" "0.000" "False" "9.554" "11" "4" "4" "4" "353" "38.6" "7.94" "11.31" "4" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00588, Pf08032" "79922" "ENSG00000274853; ENSG00000278619" "MRM1" "A8K8E2; hsa:79922; Q6IN84; Q96GK2; Q9H664" "17q12 copy number variation syndrome" "rRNA modification in the mitochondrion" "2" "0" "1.199" "1.070" "0.998" "1.106" "1.158" "0.979" "1.055" "1.100" "1.107" "190.9" "228.9" "204.2" "190.4" "211.1" "221.1" "186.9" "201.4" "210.0" "211.3" "" "" "" "" "" "" "" "" "" "" "171.6" "185.2" "184.7" "185.9" "174.2" "221.1" "139.9" "177.9" "187.9" "75.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2189358421583622075" "False" "High" "IsMasterProtein" "Q8TCY9" "Up-regulator of cell proliferation OS=Homo sapiens OX=9606 GN=URGCP PE=1 SV=2" "0.000" "False" "9.545" "4" "4" "4" "4" "931" "104.9" "6.42" "8.41" "4" "cell cycle OR cell proliferation" "cytosol;nucleus" "other molecular function" "" "55665" "ENSG00000106608" "URGCP" "E9PFF6; hsa:55665; Q658M4; Q68DH6; Q6MZZ5; Q8TCY9; Q8WV98; Q9NWR7; Q9P221" "" "" "0" "0" "1.311" "1.090" "0.848" "1.435" "1.344" "1.396" "1.190" "1.263" "1.342" "53.2" "69.7" "58.0" "45.1" "76.3" "71.5" "74.2" "63.3" "67.2" "71.4" "" "" "" "" "" "" "" "" "" "" "47.8" "56.4" "52.4" "44.0" "63.0" "71.5" "55.6" "55.9" "60.1" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1208810271641948454" "False" "High" "IsMasterProtein" "Q8NEL9" "Phospholipase DDHD1 OS=Homo sapiens OX=9606 GN=DDHD1 PE=1 SV=2" "0.000" "False" "9.531" "5" "4" "4" "4" "900" "100.4" "5.67" "11.10" "4" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf02862" "80821" "ENSG00000100523" "DDHD1" "G5E9D1; hsa:80821; Q8NEL9; Q8WVH3; Q96LL2; Q9C0F8" "" "Synthesis of PA" "1" "0" "1.059" "1.116" "1.003" "0.997" "1.073" "1.098" "1.013" "1.060" "1.264" "179.2" "189.8" "199.9" "179.8" "178.6" "192.3" "196.6" "181.5" "189.9" "226.5" "" "" "" "" "" "" "" "" "" "" "161.1" "153.5" "180.8" "175.5" "147.4" "192.3" "147.2" "160.3" "170.0" "80.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1054037842820128470" "False" "High" "IsMasterProtein" "Q9BXK1" "Krueppel-like factor 16 OS=Homo sapiens OX=9606 GN=KLF16 PE=1 SV=1" "0.000" "False" "9.531" "15" "2" "3" "2" "252" "25.4" "9.88" "13.30" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "83855" "ENSG00000129911" "KLF16" "hsa:83855; Q9BXK1" "" "" "0" "0" "1.046" "1.080" "0.908" "0.935" "1.176" "1.082" "0.962" "1.051" "1.492" "153.9" "161.0" "166.2" "139.7" "143.8" "181.0" "166.4" "148.0" "161.7" "229.5" "" "" "" "" "" "" "" "" "" "" "138.3" "130.2" "150.4" "136.4" "118.7" "181.0" "124.6" "130.8" "144.7" "81.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2552389438880602085" "False" "High" "IsMasterProtein" "Q7L5Y1" "Mitochondrial enolase superfamily member 1 OS=Homo sapiens OX=9606 GN=ENOSF1 PE=1 SV=1" "0.000" "False" "9.522" "7" "3" "3" "3" "443" "49.8" "6.48" "8.73" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf02746, Pf13378" "55556" "ENSG00000132199" "ENOSF1" "A6NMP3; A8K9R5; B3KSL6; B3KXE4; D3DUH0; hsa:55556; Q15407; Q15594; Q15595; Q6ZS08; Q7L5Y1; Q9HAS5; Q9HAS6" "" "" "0" "0" "0.961" "0.932" "0.965" "0.980" "1.165" "1.081" "1.150" "0.922" "0.989" "103.3" "99.3" "96.4" "99.7" "101.3" "120.4" "111.7" "118.8" "95.3" "102.2" "" "" "" "" "" "" "" "" "" "" "92.9" "80.4" "87.2" "97.3" "83.6" "120.4" "83.6" "104.9" "85.3" "36.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4671672968224421805" "False" "High" "IsMasterProtein" "Q9NVK5" "FGFR1 oncogene partner 2 OS=Homo sapiens OX=9606 GN=FGFR1OP2 PE=1 SV=1" "0.000" "False" "9.521" "8" "2" "3" "2" "253" "29.4" "6.00" "10.69" "2" "stress response" "cytosol" "other molecular function" "Pf05769" "26127" "ENSG00000111790" "FGFR1OP2" "hsa:26127; Q6R955; Q8N5L7; Q9NVK5; Q9P034; Q9UFK8" "" "Signaling by cytosolic FGFR1 fusion mutants; Signaling by FGFR1 in disease" "2" "0" "0.933" "0.945" "0.964" "1.140" "1.130" "0.902" "0.905" "0.987" "0.924" "139.9" "130.5" "132.2" "134.9" "159.4" "158.0" "126.2" "126.5" "138.0" "129.3" "" "" "" "" "" "" "" "" "" "" "125.8" "105.6" "119.5" "131.7" "131.5" "158.0" "94.5" "111.8" "123.5" "46.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5478644363893045592" "False" "High" "IsMasterProtein" "P60002" "Transcription elongation factor 1 homolog OS=Homo sapiens OX=9606 GN=ELOF1 PE=1 SV=1" "0.000" "False" "9.516" "22" "1" "3" "1" "83" "9.5" "8.00" "16.61" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf05129" "84337" "ENSG00000130165" "ELOF1" "hsa:84337; P60002; Q8R1J7; Q96II4" "" "" "0" "0" "0.911" "0.920" "0.906" "0.944" "1.004" "0.881" "0.953" "0.984" "0.937" "250.4" "228.1" "230.4" "226.9" "236.4" "251.3" "220.5" "238.7" "246.3" "234.6" "" "" "" "" "" "" "" "" "" "" "225.1" "184.6" "208.4" "221.4" "195.1" "251.3" "165.1" "210.8" "220.4" "83.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9052184028571704461" "False" "High" "IsMasterProtein" "O75865" "Trafficking protein particle complex subunit 6A OS=Homo sapiens OX=9606 GN=TRAPPC6A PE=1 SV=2" "0.000" "False" "9.498" "12" "2" "3" "2" "159" "17.6" "5.26" "10.38" "2" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cell component" "" "Pf04051" "79090" "ENSG00000007255" "TRAPPC6A" "hsa:79090; K7ERB1; K7ERQ4; O75865; Q9BQ45; Q9P092" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "0.896" "0.988" "0.943" "1.212" "0.912" "1.048" "1.043" "1.021" "0.949" "143.3" "128.4" "141.6" "135.1" "173.6" "130.7" "150.2" "149.5" "146.3" "136.0" "" "" "" "" "" "" "" "" "" "" "128.8" "103.9" "128.0" "131.8" "143.3" "130.7" "112.5" "132.1" "130.9" "48.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3551068469878704149" "False" "High" "IsMasterProtein" "Q9H0U6" "Large ribosomal subunit protein uL18m OS=Homo sapiens OX=9606 GN=MRPL18 PE=1 SV=1" "0.000" "False" "9.494" "15" "3" "3" "3" "180" "20.6" "9.54" "10.03" "3" "protein metabolism;other metabolic processes;transport" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00861" "29074" "ENSG00000112110" "MRPL18" "hsa:29074; Q5TAP9; Q9H0U6; Q9NZW8" "" "Mitochondrial translation elongation; Mitochondrial translation initiation; Mitochondrial translation termination" "3" "0" "1.090" "1.046" "1.019" "1.048" "1.014" "1.052" "1.020" "0.995" "1.091" "438.7" "478.1" "458.9" "447.1" "460.0" "444.8" "461.3" "447.7" "436.6" "478.8" "" "" "" "" "" "" "" "" "" "" "394.5" "386.9" "415.1" "436.5" "379.6" "444.8" "345.4" "395.4" "390.7" "170.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6043463436452304537" "False" "High" "IsMasterProtein" "Q5SSJ5" "Heterochromatin protein 1-binding protein 3 OS=Homo sapiens OX=9606 GN=HP1BP3 PE=1 SV=1" "0.000" "False" "9.491" "6" "3" "4" "3" "553" "61.2" "9.67" "12.99" "3" "cell organization and biogenesis;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00538" "50809" "ENSG00000127483" "HP1BP3" "A6NI71; A8K5D7; B3KMZ8; B4E210; hsa:50809; Q05BI0; Q5SSJ5; Q5SSJ6; Q5SWC6; Q6PIM9; Q8NDF0; Q9UHY0" "" "" "0" "0" "1.043" "0.812" "0.951" "1.053" "0.976" "1.092" "0.951" "0.988" "1.102" "146.4" "152.7" "118.8" "139.2" "154.2" "142.9" "159.9" "139.2" "144.7" "161.4" "" "" "" "" "" "" "" "" "" "" "131.6" "123.6" "107.5" "135.9" "127.2" "142.9" "119.8" "122.9" "129.5" "57.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7943802449563468851" "False" "High" "IsMasterProtein" "Q6ZU80" "Centrosomal protein of 128 kDa OS=Homo sapiens OX=9606 GN=CEP128 PE=1 SV=2" "0.000" "False" "9.477" "3" "3" "3" "3" "1094" "127.9" "6.52" "9.86" "3" "cell organization and biogenesis;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "" "" "145508" "ENSG00000100629" "CEP128" "B9EK52; hsa:145508; Q6ZU80; Q86X97; Q96ML4" "" "" "0" "0" "1.147" "1.044" "1.045" "1.113" "1.135" "0.981" "1.053" "1.117" "0.873" "236.8" "271.5" "247.3" "247.4" "263.6" "268.7" "232.2" "249.2" "264.5" "206.7" "" "" "" "" "" "" "" "" "" "" "212.9" "219.7" "223.7" "241.5" "217.5" "268.7" "173.9" "220.1" "236.7" "73.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6761620060411252827" "False" "High" "IsMasterProtein" "Q9HBH0" "Rho-related GTP-binding protein RhoF OS=Homo sapiens OX=9606 GN=RHOF PE=1 SV=1" "0.000" "False" "9.477" "17" "3" "3" "3" "211" "23.6" "8.65" "11.93" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton" "enzyme regulator activity;other molecular function" "Pf00071" "54509" "ENSG00000139725" "RHOF" "hsa:54509; Q8WVB1; Q9HBH0; Q9NXH6" "" "Neutrophil degranulation; RHOF GTPase cycle" "2" "0" "1.064" "1.071" "0.996" "1.190" "1.077" "1.143" "1.123" "1.303" "1.033" "146.2" "155.6" "156.6" "145.6" "174.1" "157.5" "167.2" "164.2" "190.6" "151.1" "" "" "" "" "" "" "" "" "" "" "131.5" "125.9" "141.7" "142.1" "143.7" "157.5" "125.2" "145.0" "170.5" "53.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7987145187797725947" "False" "High" "IsMasterProtein" "Q9H6R0" "ATP-dependent RNA helicase DHX33 OS=Homo sapiens OX=9606 GN=DHX33 PE=1 SV=2" "0.000" "False" "9.465" "4" "3" "3" "3" "707" "78.8" "8.91" "9.18" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "56919" "ENSG00000005100" "DHX33" "B4DHF9; hsa:56919; Q4G149; Q5CZ73; Q9H5M9; Q9H6R0" "" "" "0" "0" "0.892" "0.899" "0.811" "0.820" "0.948" "0.856" "0.845" "0.801" "0.783" "263.6" "235.2" "236.9" "213.8" "216.0" "249.8" "225.7" "222.8" "211.1" "206.4" "" "" "" "" "" "" "" "" "" "" "237.0" "190.3" "214.3" "208.7" "178.3" "249.8" "169.0" "196.8" "188.8" "73.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-175071030841702515" "False" "High" "IsMasterProtein" "Q96N06" "Spermatogenesis-associated protein 33 OS=Homo sapiens OX=9606 GN=SPATA33 PE=1 SV=1" "0.000" "False" "9.464" "29" "3" "3" "3" "139" "15.5" "9.22" "10.01" "3" "cell organization and biogenesis;other metabolic processes" "cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "" "Pf15382" "124045" "ENSG00000167523" "SPATA33" "A8WFL2; B4DZN8; hsa:124045; Q96N06" "" "" "0" "0" "1.278" "1.056" "1.112" "1.107" "0.984" "1.049" "0.952" "0.751" "0.448" "20.4" "26.1" "21.6" "22.7" "22.6" "20.1" "21.5" "19.5" "15.3" "9.2" "" "" "" "" "" "" "" "" "" "" "18.4" "21.1" "19.5" "22.2" "18.7" "20.1" "16.1" "17.2" "13.7" "3.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8273145356875318632" "False" "High" "IsMasterProtein" "Q9BXI6" "TBC1 domain family member 10A OS=Homo sapiens OX=9606 GN=TBC1D10A PE=1 SV=1" "0.000" "False" "9.449" "6" "3" "3" "3" "508" "57.1" "8.44" "10.52" "3" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "83874" "ENSG00000099992" "TBC1D10A" "B3KXT8; hsa:83874; O76053; Q20WK7; Q543A2; Q9BXI6" "Deregulation of Rab and Rab effector genes in bladder cancer" "TBC/RABGAPs" "2" "0" "1.023" "0.995" "1.126" "1.163" "1.157" "1.149" "1.173" "1.245" "1.231" "132.9" "136.0" "132.2" "149.7" "154.6" "153.8" "152.8" "155.9" "165.5" "163.6" "" "" "" "" "" "" "" "" "" "" "119.5" "110.0" "119.6" "146.1" "127.6" "153.8" "114.4" "137.7" "148.1" "58.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-139215625365560454" "False" "High" "IsMasterProtein" "O00566" "U3 small nucleolar ribonucleoprotein protein MPP10 OS=Homo sapiens OX=9606 GN=MPHOSPH10 PE=1 SV=2" "0.000" "False" "9.436" "6" "3" "3" "3" "681" "78.8" "4.86" "9.99" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf04006" "10199" "ENSG00000124383" "MPHOSPH10" "A0AVJ8; hsa:10199; O00566" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.992" "1.044" "1.103" "1.130" "1.032" "1.062" "1.053" "1.068" "0.714" "156.2" "155.0" "163.2" "172.3" "176.6" "161.3" "166.0" "164.6" "166.8" "111.5" "" "" "" "" "" "" "" "" "" "" "140.5" "125.5" "147.6" "168.2" "145.7" "161.3" "124.3" "145.4" "149.3" "39.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7091276917323746637" "False" "High" "IsMasterProtein" "Q9H008" "Phospholysine phosphohistidine inorganic pyrophosphate phosphatase OS=Homo sapiens OX=9606 GN=LHPP PE=1 SV=2" "0.000" "False" "9.418" "17" "3" "3" "3" "270" "29.1" "6.15" "11.93" "3" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf13242, Pf13344" "64077" "ENSG00000107902" "LHPP" "B3KP20; hsa:64077; Q2TBE9; Q5VUV9; Q5VUW0; Q9H008" "" "Pyrophosphate hydrolysis" "1" "0" "0.937" "1.023" "0.889" "1.054" "0.965" "1.017" "0.979" "1.024" "0.734" "213.0" "199.5" "217.9" "189.4" "224.5" "205.5" "216.8" "208.6" "218.2" "156.4" "" "" "" "" "" "" "" "" "" "" "191.5" "161.5" "197.1" "184.9" "185.2" "205.5" "162.3" "184.2" "195.2" "55.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7618289525843205014" "False" "High" "IsMasterProtein" "Q7L8W6" "Diphthine--ammonia ligase OS=Homo sapiens OX=9606 GN=DPH6 PE=1 SV=3" "0.000" "False" "9.411" "12" "3" "5" "3" "267" "30.3" "5.40" "11.09" "3" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01902" "89978" "ENSG00000134146" "DPH6" "B3KWG1; hsa:89978; Q7L8W6; Q96HJ6" "" "Synthesis of diphthamide-EEF2" "1" "0" "0.898" "1.027" "0.969" "0.915" "0.972" "1.031" "0.991" "1.013" "1.055" "192.7" "173.0" "198.0" "186.7" "176.3" "187.4" "198.6" "190.9" "195.2" "203.2" "" "" "" "" "" "" "" "" "" "" "173.3" "140.0" "179.1" "182.2" "145.5" "187.4" "148.7" "168.6" "174.7" "72.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7103280702382610433" "False" "High" "IsMasterProtein" "Q8IX90" "Spindle and kinetochore-associated protein 3 OS=Homo sapiens OX=9606 GN=SKA3 PE=1 SV=2" "0.000" "False" "9.399" "8" "3" "3" "3" "412" "46.3" "5.11" "11.21" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "" "221150" "ENSG00000165480" "SKA3" "A2A330; A2A331; B2RBY2; hsa:221150; Q5VZV5; Q86WR2; Q8IX90; Q8NBG1; Q96D22" "" "" "0" "0" "1.082" "1.172" "1.011" "1.081" "1.191" "1.093" "1.091" "1.188" "1.846" "360.0" "389.6" "421.8" "364.0" "389.1" "428.7" "393.5" "392.7" "427.8" "664.4" "" "" "" "" "" "" "" "" "" "" "323.7" "315.2" "381.5" "355.3" "321.1" "428.7" "294.6" "346.9" "382.8" "237.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8398668130488909755" "False" "High" "IsMasterProtein" "Q9BXL7" "Caspase recruitment domain-containing protein 11 OS=Homo sapiens OX=9606 GN=CARD11 PE=1 SV=3" "0.000" "False" "9.398" "3" "4" "4" "4" "1154" "133.2" "6.09" "11.31" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "kinase activity;other molecular function" "Pf00619" "84433" "ENSG00000198286" "CARD11" "A4D1Z7; hsa:84433; Q2NKN7; Q548H3; Q9BXL7" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling" "8" "0" "1.042" "1.011" "0.923" "0.991" "1.042" "0.972" "0.959" "0.958" "1.481" "217.7" "226.9" "220.1" "200.9" "215.7" "226.9" "211.5" "208.8" "208.7" "322.3" "" "" "" "" "" "" "" "" "" "" "195.7" "183.6" "199.1" "196.1" "178.0" "226.9" "158.4" "184.4" "186.7" "115.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4044629129436372468" "False" "High" "IsMasterProtein" "Q14160" "Protein scribble homolog OS=Homo sapiens OX=9606 GN=SCRIB PE=1 SV=5" "0.000" "False" "9.393" "2" "4" "4" "4" "1630" "174.8" "5.07" "10.55" "4" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00560, Pf00595, Pf13855" "23513" "ENSG00000180900; ENSG00000274287" "SCRIB" "hsa:23513; Q14160; Q6P496; Q7Z5D1; Q8WWV8; Q96C69; Q96GG1" "Thyroid stimulating hormone (TSH) signaling pathway; Complement system in neuronal development and plasticity" "CDC42 GTPase cycle; RHOQ GTPase cycle; RHOJ GTPase cycle; Asymmetric localization of PCP proteins; RND2 GTPase cycle; RND3 GTPase cycle" "8" "0" "0.941" "0.944" "0.864" "0.931" "0.928" "0.909" "0.851" "0.786" "2.027" "312.4" "294.0" "295.0" "270.0" "290.8" "289.9" "283.9" "265.8" "245.7" "633.4" "" "" "" "" "" "" "" "" "" "" "280.9" "237.9" "266.8" "263.5" "240.0" "289.9" "212.6" "234.7" "219.9" "226.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3028441251658952013" "False" "High" "IsMasterProtein" "Q9H7L9" "Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens OX=9606 GN=SUDS3 PE=1 SV=2" "0.000" "False" "9.391" "5" "2" "3" "2" "328" "38.1" "5.66" "11.04" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus" "other molecular function" "Pf08598" "64426" "ENSG00000111707" "SUDS3" "hsa:64426; Q4KMQ5; Q8N6H0; Q9H7L9; Q9H8D2" "" "Ub-specific processing proteases; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; Potential therapeutics for SARS" "4" "0" "0.957" "0.985" "1.061" "0.928" "1.017" "1.037" "0.904" "1.111" "1.579" "128.8" "123.2" "126.9" "136.6" "119.6" "131.0" "133.6" "116.4" "143.0" "203.3" "" "" "" "" "" "" "" "" "" "" "115.8" "99.7" "114.8" "133.3" "98.7" "131.0" "100.0" "102.8" "128.0" "72.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5738973645522844846" "False" "High" "IsMasterProtein" "Q5MNZ6" "WD repeat domain phosphoinositide-interacting protein 3 OS=Homo sapiens OX=9606 GN=WDR45B PE=1 SV=2" "0.000" "False" "9.387" "11" "3" "4" "2" "344" "38.1" "7.59" "12.00" "3" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf21032" "56270" "ENSG00000141580" "WDR45B" "A0A024R8U4; A0A218N098; hsa:56270; O95328; Q2MCP6; Q5MNZ6; Q6IBN2" "8q11.23 (RB1CC1) copy number variation" "Macroautophagy" "2" "0" "1.014" "0.976" "1.125" "1.200" "0.988" "1.182" "1.237" "1.034" "0.750" "121.6" "123.3" "118.7" "136.9" "146.0" "120.2" "143.8" "150.4" "125.8" "91.3" "" "" "" "" "" "" "" "" "" "" "109.4" "99.8" "107.4" "133.6" "120.5" "120.2" "107.6" "132.9" "112.6" "32.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3308580739570590446" "False" "High" "IsMasterProtein" "Q8WVL7" "Ankyrin repeat domain-containing protein 49 OS=Homo sapiens OX=9606 GN=ANKRD49 PE=1 SV=1" "0.000" "False" "9.385" "13" "3" "3" "3" "239" "27.3" "5.15" "10.36" "3" "other biological processes" "nucleus" "" "Pf12796" "54851" "ENSG00000168876" "ANKRD49" "hsa:54851; Q8NDF2; Q8WVL7; Q96JE5; Q9NXK7" "" "" "0" "0" "1.034" "1.105" "0.923" "1.083" "1.001" "0.965" "0.971" "0.971" "0.829" "201.5" "208.3" "222.6" "186.0" "218.2" "201.6" "194.5" "195.7" "195.6" "167.1" "" "" "" "" "" "" "" "" "" "" "181.2" "168.5" "201.4" "181.6" "180.0" "201.6" "145.6" "172.8" "175.1" "59.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4083162840287628806" "False" "High" "IsMasterProtein" "O60641" "Clathrin coat assembly protein AP180 OS=Homo sapiens OX=9606 GN=SNAP91 PE=1 SV=2" "0.000" "False" "9.376" "4" "3" "3" "1" "907" "92.4" "4.86" "5.99" "3" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07651" "9892" "ENSG00000065609" "SNAP91" "A8K0L7; E5RI02; hsa:9892; O60641; Q5JX13; Q68DL9; Q6P9D3; Q9NTY7" "" "Cargo recognition for clathrin-mediated endocytosis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-6599360429670756188" "False" "High" "IsMasterProtein" "Q92902" "BLOC-3 complex member HPS1 OS=Homo sapiens OX=9606 GN=HPS1 PE=1 SV=2" "0.000" "False" "9.369" "5" "3" "3" "3" "700" "79.2" "5.91" "11.35" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf19036, Pf19037, Pf19038" "3257" "ENSG00000107521" "HPS1" "A8MRT2; O15402; O15502; Q5TAA3; Q8WXE5; Q92902" "IL-18 signaling pathway" "RAB GEFs exchange GTP for GDP on RABs" "2" "0" "0.971" "0.980" "0.974" "0.925" "0.848" "0.855" "0.916" "0.951" "1.092" "313.2" "304.2" "307.1" "305.1" "289.8" "265.6" "267.9" "287.1" "297.9" "341.9" "" "" "" "" "" "" "" "" "" "" "281.6" "246.2" "277.8" "297.8" "239.2" "265.6" "200.6" "253.5" "266.6" "122.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8397270974056062959" "False" "High" "IsMasterProtein" "Q9NRL3" "Striatin-4 OS=Homo sapiens OX=9606 GN=STRN4 PE=1 SV=2" "0.000" "False" "9.367" "5" "3" "3" "2" "753" "80.5" "5.40" "11.29" "3" "" "other membranes;other cell component" "other molecular function" "Pf00400, Pf08232" "29888" "ENSG00000090372" "STRN4" "A0A024R0V2; B4DQH7; F8VYA6; hsa:29888; Q8NE53; Q9NRL3" "" "" "0" "0" "0.877" "1.143" "0.904" "0.886" "0.970" "1.023" "0.841" "1.051" "0.737" "62.1" "54.4" "70.9" "56.1" "55.0" "60.2" "63.5" "52.2" "65.2" "45.7" "" "" "" "" "" "" "" "" "" "" "55.8" "44.0" "64.1" "54.8" "45.4" "60.2" "47.6" "46.1" "58.4" "16.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4572995838386066943" "False" "High" "IsMasterProtein" "Q13568" "Interferon regulatory factor 5 OS=Homo sapiens OX=9606 GN=IRF5 PE=1 SV=2" "0.000" "False" "9.355" "6" "3" "3" "3" "498" "56.0" "5.77" "10.37" "3" "stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605, Pf10401" "3663" "ENSG00000128604" "IRF5" "A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54; hsa:3663; Q13568; Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0" "Apoptosis; Vitamin D receptor pathway; miRNA role in immune response in sepsis; p53 transcriptional gene network; Genes associated with the development of rheumatoid arthritis; Orexin receptor pathway; Toll-like receptor signaling pathway" "Interferon gamma signaling; Interferon alpha/beta signaling" "9" "0" "0.982" "1.000" "0.868" "0.950" "1.005" "0.908" "1.006" "0.947" "1.209" "369.5" "362.8" "369.3" "320.7" "351.0" "371.4" "335.5" "371.8" "349.9" "446.5" "" "" "" "" "" "" "" "" "" "" "332.2" "293.6" "334.0" "313.0" "289.6" "371.4" "251.2" "328.4" "313.1" "159.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8110732802669380645" "False" "High" "IsMasterProtein" "P24864" "G1/S-specific cyclin-E1 OS=Homo sapiens OX=9606 GN=CCNE1 PE=1 SV=2" "0.000" "False" "9.348" "8" "3" "4" "2" "410" "47.0" "6.04" "14.52" "3" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00134, Pf02984" "898" "ENSG00000105173" "CCNE1" "A8K684; hsa:898; P24864; Q14091; Q8NFG1; Q92501; Q9UD21" "Androgen receptor signaling pathway; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Glioblastoma signaling pathways; Parkin-ubiquitin proteasomal system pathway; Parkinson's disease pathway; Retinoblastoma gene in cancer; ATM signaling pathway; Vitamin D receptor pathway; Photodynamic therapy-induced AP-1 survival signaling; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; p53 transcriptional gene network; Pleural mesothelioma; GDNF signaling; Urotensin-II-mediated signaling pathway; ID signaling pathway; TROP2 regulatory signaling; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHOBTB3 ATPase cycle; DNA Damage/Telomere Stress Induced Senescence; G1/S-Specific Transcription; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response; PTK6 Regulates Cell Cycle" "38" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8781078747776304120" "False" "High" "IsMasterProtein" "Q9NY12" "H/ACA ribonucleoprotein complex subunit 1 OS=Homo sapiens OX=9606 GN=GAR1 PE=1 SV=1" "0.000" "False" "9.347" "16" "3" "3" "3" "217" "22.3" "10.92" "10.77" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf04410" "54433" "ENSG00000109534" "GAR1" "hsa:54433; Q5MJQ2; Q9NY12" "" "rRNA modification in the nucleus and cytosol; Telomere Extension By Telomerase" "2" "0" "0.904" "0.899" "0.937" "0.915" "1.026" "0.938" "0.811" "0.844" "1.007" "106.1" "95.9" "95.4" "99.4" "97.0" "108.8" "99.5" "86.0" "89.5" "106.8" "" "" "" "" "" "" "" "" "" "" "95.4" "77.6" "86.3" "97.0" "80.1" "108.8" "74.5" "76.0" "80.1" "38.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7072278322173443531" "False" "High" "IsMasterProtein" "Q8N371" "Bifunctional peptidase and arginyl-hydroxylase JMJD5 OS=Homo sapiens OX=9606 GN=KDM8 PE=1 SV=1" "0.000" "False" "9.339" "9" "3" "3" "3" "416" "47.2" "5.80" "6.13" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13621" "79831" "ENSG00000155666" "KDM8" "B4DLU9; hsa:79831; Q6VAK5; Q8N371; Q9H8B1" "" "Protein hydroxylation" "1" "0" "1.009" "1.053" "0.915" "1.030" "0.985" "1.046" "1.012" "0.938" "0.806" "165.3" "166.8" "174.2" "151.3" "170.3" "162.8" "172.9" "167.3" "155.1" "133.2" "" "" "" "" "" "" "" "" "" "" "148.6" "134.9" "157.5" "147.7" "140.5" "162.8" "129.5" "147.7" "138.8" "47.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8350052096889729945" "False" "High" "IsMasterProtein" "O95670" "V-type proton ATPase subunit G 2 OS=Homo sapiens OX=9606 GN=ATP6V1G2 PE=1 SV=1" "0.000" "False" "9.333" "35" "4" "4" "4" "118" "13.6" "10.26" "7.13" "4" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf03179" "534" "ENSG00000206445; ENSG00000213760; ENSG00000226850; ENSG00000227587; ENSG00000230900; ENSG00000234668; ENSG00000234920" "ATP6V1G2" "B5MEF0; hsa:534; O95670; Q2L6F8; Q5HYU8; Q5RJ63" "" "Amino acids regulate mTORC1; ROS and RNS production in phagocytes; Insulin receptor recycling; Transferrin endocytosis and recycling; Ion channel transport" "5" "0" "1.328" "1.130" "0.969" "1.448" "1.490" "1.432" "1.310" "1.112" "0.993" "27.9" "37.1" "31.5" "27.0" "40.4" "41.6" "39.9" "36.5" "31.0" "27.7" "" "" "" "" "" "" "" "" "" "" "25.1" "30.0" "28.5" "26.4" "33.3" "41.6" "29.9" "32.3" "27.7" "9.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7081455264055243390" "False" "High" "IsMasterProtein" "Q16658" "Fascin OS=Homo sapiens OX=9606 GN=FSCN1 PE=1 SV=3" "0.000" "False" "9.323" "6" "3" "3" "3" "493" "54.5" "7.24" "11.70" "3" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf06268" "6624" "ENSG00000075618" "FSCN1" "A6NI89; B2RE97; hsa:6624; Q16658; Q96IC5; Q96IH1; Q9BRF1" "VEGFA-VEGFR2 signaling; Urotensin-II-mediated signaling pathway" "Interleukin-4 and Interleukin-13 signaling" "3" "0" "1.078" "1.253" "1.050" "1.002" "1.037" "1.034" "1.074" "1.154" "1.045" "68.4" "73.7" "85.8" "71.8" "68.6" "71.0" "70.7" "73.5" "78.9" "71.5" "" "" "" "" "" "" "" "" "" "" "61.5" "59.7" "77.6" "70.1" "56.6" "71.0" "53.0" "64.9" "70.6" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "295020939105715533" "False" "High" "IsMasterProtein" "Q9NRS6" "Sorting nexin-15 OS=Homo sapiens OX=9606 GN=SNX15 PE=1 SV=1" "0.000" "False" "9.321" "8" "3" "3" "3" "342" "38.3" "5.19" "10.68" "3" "transport" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00787, Pf04212" "29907" "ENSG00000110025" "SNX15" "E5KQS6; hsa:29907; Q9NRS5; Q9NRS6" "" "" "0" "0" "1.064" "1.196" "1.095" "1.105" "1.131" "1.081" "1.267" "1.199" "2.397" "109.8" "116.8" "131.3" "120.2" "121.3" "124.1" "118.7" "139.1" "131.7" "263.2" "" "" "" "" "" "" "" "" "" "" "98.7" "94.5" "118.8" "117.3" "100.1" "124.1" "88.9" "122.8" "117.8" "93.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6142144855289123481" "False" "High" "IsMasterProtein" "Q96HC4" "PDZ and LIM domain protein 5 OS=Homo sapiens OX=9606 GN=PDLIM5 PE=1 SV=5" "0.000" "False" "9.309" "6" "3" "3" "3" "596" "63.9" "8.21" "11.29" "3" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00412, Pf00595" "10611" "ENSG00000163110" "PDLIM5" "A8K6F9; D6RB78; E9PBF5; hsa:10611; O60705; Q56VN4; Q5UW38; Q8WVK0; Q96HC4" "Extracellular vesicles in the crosstalk of cardiac cells" "Neurexins and neuroligins" "2" "0" "1.003" "1.035" "0.989" "1.081" "1.050" "1.037" "1.032" "1.042" "0.947" "207.7" "208.4" "215.1" "205.5" "224.5" "218.0" "215.3" "214.4" "216.5" "196.7" "" "" "" "" "" "" "" "" "" "" "186.8" "168.6" "194.5" "200.6" "185.3" "218.0" "161.2" "189.4" "193.7" "70.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653073458972591476" "False" "High" "IsMasterProtein" "O75683" "Surfeit locus protein 6 OS=Homo sapiens OX=9606 GN=SURF6 PE=1 SV=3" "0.000" "False" "9.292" "8" "3" "4" "3" "361" "41.4" "10.64" "9.53" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04935" "6838" "ENSG00000148296; ENSG00000281309" "SURF6" "hsa:6838; O75683; Q5T8U1; Q9BRK9; Q9BTZ5; Q9UK24" "" "" "0" "0" "1.174" "0.798" "1.183" "0.970" "0.772" "1.150" "1.113" "0.624" "0.397" "32.1" "37.7" "25.6" "38.0" "31.2" "24.8" "37.0" "35.8" "20.0" "12.8" "" "" "" "" "" "" "" "" "" "" "28.9" "30.5" "23.2" "37.1" "25.7" "24.8" "27.7" "31.6" "17.9" "4.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1707111681236337832" "False" "High" "IsMasterProtein" "Q96BY7" "Autophagy-related protein 2 homolog B OS=Homo sapiens OX=9606 GN=ATG2B PE=1 SV=5" "0.000" "False" "9.286" "2" "4" "4" "4" "2078" "232.6" "5.76" "11.59" "4" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf09333, Pf12624, Pf13329" "55102" "ENSG00000066739" "ATG2B" "hsa:55102; Q6ZRE7; Q96BY7; Q96DQ3; Q9NW80" "Alzheimer's disease and miRNA effects; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Alzheimer's disease" "" "3" "0" "0.971" "0.889" "0.935" "0.966" "0.996" "0.996" "1.017" "0.969" "0.907" "141.8" "137.7" "126.1" "132.7" "137.0" "141.3" "141.3" "144.2" "137.4" "128.7" "" "" "" "" "" "" "" "" "" "" "127.5" "111.4" "114.0" "129.5" "113.1" "141.3" "105.8" "127.4" "122.9" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2665398799840712854" "False" "High" "IsMasterProtein" "Q5VWJ9" "Sorting nexin-30 OS=Homo sapiens OX=9606 GN=SNX30 PE=1 SV=1" "0.000" "False" "9.277" "11" "4" "4" "4" "437" "49.6" "5.35" "13.50" "4" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00787, Pf03114" "401548" "ENSG00000148158" "SNX30" "hsa:401548; Q5VWJ9" "" "" "0" "0" "1.008" "1.030" "1.024" "1.029" "1.052" "0.935" "1.010" "0.995" "1.775" "199.6" "201.2" "205.5" "204.3" "205.4" "209.8" "186.6" "201.6" "198.5" "354.2" "" "" "" "" "" "" "" "" "" "" "179.4" "162.8" "185.9" "199.4" "169.5" "209.8" "139.7" "178.1" "177.6" "126.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4415250102849728185" "False" "High" "IsMasterProtein" "Q76FK4" "Nucleolar protein 8 OS=Homo sapiens OX=9606 GN=NOL8 PE=1 SV=1" "0.000" "False" "9.272" "3" "4" "4" "4" "1167" "131.5" "7.09" "8.39" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00076" "55035" "ENSG00000198000; ENSG00000291347" "NOL8" "hsa:55035; Q5TCC7; Q5TCC8; Q5TCD3; Q5TCD5; Q5TCD6; Q5TCD7; Q76D35; Q76FK4; Q7L3E2; Q9H586; Q9H795; Q9H7W7; Q9H9J6; Q9NWA4; Q9NWM4" "" "" "0" "0" "1.066" "1.023" "1.026" "1.099" "1.120" "1.121" "0.940" "1.004" "1.372" "187.2" "199.5" "191.4" "192.1" "205.8" "209.7" "209.9" "176.0" "188.1" "256.9" "" "" "" "" "" "" "" "" "" "" "168.3" "161.5" "173.2" "187.5" "169.8" "209.7" "157.2" "155.4" "168.3" "91.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4850932002920581345" "False" "High" "IsMasterProtein" "Q96GX5" "Serine/threonine-protein kinase greatwall OS=Homo sapiens OX=9606 GN=MASTL PE=1 SV=1" "0.000" "False" "9.250" "3" "3" "6" "2" "879" "97.3" "5.99" "22.86" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "84930" "ENSG00000120539" "MASTL" "hsa:84930; Q5T8D5; Q5T8D7; Q8NCD6; Q96GX5; Q96SJ5" "" "MASTL Facilitates Mitotic Progression" "1" "0" "1.096" "1.326" "1.261" "1.084" "1.474" "1.230" "1.218" "1.408" "2.496" "121.6" "133.2" "161.3" "153.4" "131.8" "179.3" "149.6" "148.1" "171.2" "303.6" "" "" "" "" "" "" "" "" "" "" "109.3" "107.8" "145.9" "149.7" "108.8" "179.3" "112.0" "130.8" "153.2" "108.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8474719942598486325" "False" "High" "IsMasterProtein" "Q8WYA6" "Beta-catenin-like protein 1 OS=Homo sapiens OX=9606 GN=CTNNBL1 PE=1 SV=1" "0.000" "False" "9.248" "6" "4" "4" "4" "563" "65.1" "5.05" "10.49" "4" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf08216" "56259" "ENSG00000132792" "CTNNBL1" "B4DE16; hsa:56259; Q0VAL9; Q0VAM0; Q53HI8; Q5JWZ2; Q5JWZ3; Q5JWZ7; Q5JWZ8; Q8N454; Q8NCL2; Q8TBD6; Q8WYA6; Q96KD2; Q9H7A5; Q9NQF9; Q9NTX0; Q9Y3M7" "" "mRNA Splicing - Major Pathway" "1" "0" "1.115" "0.957" "1.013" "1.097" "1.003" "1.167" "0.727" "0.846" "13.390" "241.6" "269.5" "231.3" "244.8" "265.0" "242.4" "282.0" "175.7" "204.5" "3235.4" "" "" "" "" "" "" "" "" "" "" "217.2" "218.0" "209.2" "238.9" "218.7" "242.4" "211.1" "155.2" "183.0" "1155.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7182522188647620429" "False" "High" "IsMasterProtein" "Q8N3L3" "Beta-taxilin OS=Homo sapiens OX=9606 GN=TXLNB PE=1 SV=3" "0.000" "False" "9.230" "6" "4" "4" "3" "684" "76.5" "4.93" "12.08" "4" "" "other cell component" "other molecular function" "Pf09728" "167838" "ENSG00000164440" "TXLNB" "hsa:167838; Q5HYH7; Q5VTF3; Q76L25; Q86T52; Q8N3L3; Q8N3S2" "" "" "0" "0" "0.916" "1.029" "0.859" "1.157" "1.009" "0.929" "1.082" "1.024" "0.886" "60.3" "55.2" "62.0" "51.8" "69.7" "60.8" "56.0" "65.2" "61.7" "53.4" "" "" "" "" "" "" "" "" "" "" "54.2" "44.7" "56.1" "50.5" "57.5" "60.8" "41.9" "57.6" "55.2" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8719462215085106760" "False" "High" "IsMasterProtein" "Q8N983" "Large ribosomal subunit protein mL43 OS=Homo sapiens OX=9606 GN=MRPL43 PE=1 SV=1" "0.000" "False" "9.226" "15" "4" "4" "4" "215" "23.4" "8.65" "12.99" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf05047" "84545" "ENSG00000055950" "MRPL43" "B1AL06; B1AL07; B1AL09; B1AL10; C9J5Q3; D3DR71; hsa:84545; Q5JW06; Q7Z719; Q7Z7H6; Q86XN1; Q8N983; Q9BYC7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.009" "0.954" "0.903" "1.019" "0.963" "1.054" "0.978" "1.002" "1.125" "551.9" "556.9" "526.3" "498.1" "562.3" "531.2" "581.8" "540.0" "553.1" "621.1" "" "" "" "" "" "" "" "" "" "" "496.2" "450.7" "476.1" "486.2" "464.0" "531.2" "435.7" "476.9" "494.9" "221.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3715584417028259664" "False" "High" "IsMasterProtein" "P56381" "ATP synthase subunit epsilon, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5F1E PE=1 SV=2" "0.000" "False" "9.213" "59" "4" "6" "4" "51" "5.8" "9.92" "16.69" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf04627" "514" "ENSG00000124172" "ATP5F1E" "B2RDD0; E1P5H6; hsa:514; P56381; Q53XU6" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "1.057" "1.019" "1.163" "0.970" "1.128" "1.020" "1.029" "1.104" "0.733" "1006.1" "1063.1" "1025.1" "1170.2" "976.0" "1135.4" "1026.5" "1035.5" "1111.0" "737.4" "" "" "" "" "" "" "" "" "" "" "904.6" "860.2" "927.2" "1142.2" "805.4" "1135.4" "768.6" "914.6" "994.1" "263.2" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4970253198694079027" "False" "High" "IsMasterProtein" "Q96BW1" "Uracil phosphoribosyltransferase homolog OS=Homo sapiens OX=9606 GN=UPRT PE=1 SV=1" "0.000" "False" "9.200" "10" "3" "3" "3" "309" "33.8" "6.04" "11.48" "3" "other metabolic processes;transport;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf14681" "139596" "ENSG00000094841" "UPRT" "hsa:139596; Q5JRL1; Q5JRL3; Q68DN0; Q96BW1; Q96MW2" "Pyrimidine metabolism" "" "1" "0" "0.999" "0.946" "0.891" "1.032" "1.066" "0.946" "0.993" "0.997" "1.048" "234.4" "234.1" "221.9" "208.9" "241.9" "250.0" "221.8" "232.7" "233.8" "245.8" "" "" "" "" "" "" "" "" "" "" "210.8" "189.4" "200.7" "203.9" "199.6" "250.0" "166.1" "205.5" "209.2" "87.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6507814139192882220" "False" "High" "IsMasterProtein" "Q9H6K1" "Protein ILRUN OS=Homo sapiens OX=9606 GN=ILRUN PE=1 SV=2" "0.000" "False" "9.196" "17" "3" "3" "3" "298" "32.9" "4.58" "10.78" "3" "other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14555, Pf16158" "64771" "ENSG00000196821" "ILRUN" "B2R8K7; hsa:64771; Q5VV77; Q96MG5; Q9BUR9; Q9H6K1" "" "" "0" "0" "1.038" "1.104" "1.017" "1.218" "1.044" "1.204" "1.097" "1.057" "1.143" "272.9" "283.2" "301.3" "277.6" "332.3" "285.0" "328.7" "299.4" "288.4" "312.0" "" "" "" "" "" "" "" "" "" "" "245.3" "229.1" "272.6" "271.0" "274.2" "285.0" "246.1" "264.4" "258.0" "111.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2204752013873116397" "False" "High" "IsMasterProtein" "Q8IV20" "Purine nucleoside phosphorylase LACC1 OS=Homo sapiens OX=9606 GN=LACC1 PE=1 SV=1" "0.000" "False" "9.185" "7" "3" "3" "3" "430" "47.7" "7.06" "10.98" "3" "stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf02578" "144811" "ENSG00000179630" "LACC1" "A2A3Z6; hsa:144811; Q8IV20; Q8N8X5" "" "" "0" "0" "0.983" "0.912" "0.876" "0.974" "0.923" "0.951" "0.930" "0.835" "0.973" "159.9" "157.3" "145.9" "140.1" "155.7" "147.6" "152.1" "148.8" "133.6" "155.7" "" "" "" "" "" "" "" "" "" "" "143.8" "127.3" "132.0" "136.8" "128.5" "147.6" "113.9" "131.4" "119.5" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "213953215988823024" "False" "High" "IsMasterProtein" "Q92896" "Golgi apparatus protein 1 OS=Homo sapiens OX=9606 GN=GLG1 PE=1 SV=2" "0.000" "False" "9.177" "3" "2" "2" "2" "1179" "134.5" "6.90" "10.75" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytoskeleton;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf00839" "2734" "ENSG00000090863" "GLG1" "B7Z8Y4; D3DUJ7; hsa:2734; Q13221; Q6P9D1; Q92896" "" "Cell surface interactions at the vascular wall" "1" "0" "0.903" "0.921" "0.988" "0.932" "0.943" "1.008" "0.924" "1.013" "0.675" "173.5" "156.6" "159.8" "171.4" "161.6" "163.7" "174.8" "160.2" "175.7" "117.2" "" "" "" "" "" "" "" "" "" "" "156.0" "126.7" "144.6" "167.3" "133.4" "163.7" "130.9" "141.5" "157.3" "41.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2002470481848011023" "False" "High" "IsMasterProtein" "Q9P032" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 OS=Homo sapiens OX=9606 GN=NDUFAF4 PE=1 SV=1" "0.000" "False" "9.174" "19" "4" "4" "4" "175" "20.3" "8.82" "13.06" "4" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf06784" "29078" "ENSG00000123545" "NDUFAF4" "B2R4J5; hsa:29078; Q9P032" "" "Complex I biogenesis" "1" "0" "0.927" "1.010" "0.996" "0.950" "0.978" "1.031" "0.926" "0.991" "1.092" "743.1" "688.7" "750.8" "739.8" "706.1" "726.6" "766.1" "688.1" "736.5" "811.6" "" "" "" "" "" "" "" "" "" "" "668.1" "557.3" "679.1" "722.2" "582.7" "726.6" "573.7" "607.8" "659.0" "289.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "735333771594595677" "False" "High" "IsMasterProtein" "Q9BYN8" "Small ribosomal subunit protein mS26 OS=Homo sapiens OX=9606 GN=MRPS26 PE=1 SV=1" "0.000" "False" "9.159" "16" "4" "5" "4" "205" "24.2" "10.39" "16.33" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus" "" "Pf14943" "64949" "ENSG00000125901" "MRPS26" "hsa:64949; Q96Q58; Q9BYN8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.926" "0.884" "0.947" "0.858" "0.850" "0.918" "0.840" "0.898" "1.489" "574.8" "532.3" "507.9" "544.6" "492.9" "488.4" "527.4" "482.9" "516.4" "856.0" "" "" "" "" "" "" "" "" "" "" "516.8" "430.7" "459.4" "531.6" "406.8" "488.4" "394.9" "426.5" "462.1" "305.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1820154667624248039" "False" "High" "IsMasterProtein" "P54098" "DNA polymerase subunit gamma-1 OS=Homo sapiens OX=9606 GN=POLG PE=1 SV=1" "0.000" "False" "9.142" "3" "4" "4" "4" "1239" "139.5" "6.90" "12.67" "4" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf18136" "5428" "ENSG00000140521" "POLG" "hsa:5428; P54098; Q8NFM2; Q92515" "Male infertility; Primary ovarian insufficiency" "" "2" "0" "1.142" "0.846" "0.929" "1.037" "0.924" "1.096" "0.959" "0.966" "1.261" "172.2" "196.6" "145.7" "159.9" "178.5" "159.1" "188.8" "165.2" "166.3" "217.1" "" "" "" "" "" "" "" "" "" "" "154.8" "159.1" "131.8" "156.1" "147.3" "159.1" "141.4" "145.9" "148.8" "77.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240995388596956577" "False" "High" "IsMasterProtein" "Q08379" "Golgin subfamily A member 2 OS=Homo sapiens OX=9606 GN=GOLGA2 PE=1 SV=3" "0.000" "False" "9.131" "3" "3" "3" "3" "1002" "113.0" "5.02" "8.02" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytoskeleton;ER/Golgi;other cell component" "cytoskeletal activity;other molecular function" "Pf15070, Pf19046" "2801" "ENSG00000167110" "GOLGA2" "A0A0C4DGS5; hsa:2801; Q08379; Q6GRM9; Q9BRB0; Q9NYF9" "" "COPI-mediated anterograde transport; COPII-mediated vesicle transport; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; Golgi Cisternae Pericentriolar Stack Reorganization" "4" "0" "1.025" "1.179" "0.973" "1.387" "1.235" "1.221" "1.464" "1.207" "1.186" "45.6" "46.7" "53.7" "44.4" "63.2" "56.3" "55.6" "66.7" "55.0" "54.1" "" "" "" "" "" "" "" "" "" "" "41.0" "37.8" "48.6" "43.3" "52.1" "56.3" "41.7" "58.9" "49.2" "19.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4999747194437679436" "False" "High" "IsMasterProtein" "Q969M7" "NEDD8-conjugating enzyme UBE2F OS=Homo sapiens OX=9606 GN=UBE2F PE=1 SV=1" "0.000" "False" "9.130" "20" "3" "3" "3" "185" "21.1" "6.79" "13.55" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179" "140739" "ENSG00000184182" "UBE2F" "A8K1Z8; B4DDT9; B4DFI1; B4DMK3; B4DZU2; B8ZZG2; C9J212; H9KVB9; Q969M7" "2q37 copy number variation syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "1.042" "0.993" "1.085" "1.124" "1.141" "1.194" "1.251" "1.216" "1.050" "114.7" "119.5" "114.0" "124.5" "128.9" "130.9" "137.0" "143.5" "139.5" "120.4" "" "" "" "" "" "" "" "" "" "" "103.2" "96.7" "103.1" "121.6" "106.4" "130.9" "102.6" "126.8" "124.8" "43.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3476317971320699033" "False" "High" "IsMasterProtein" "O43156" "TELO2-interacting protein 1 homolog OS=Homo sapiens OX=9606 GN=TTI1 PE=1 SV=3" "0.000" "False" "9.129" "3" "3" "3" "3" "1089" "122.0" "5.97" "11.45" "3" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf21547" "9675" "ENSG00000101407" "TTI1" "D6W4K3; hsa:9675; O43156; Q5JX67; Q96A38; Q9BR47; Q9H4K0" "Fragile X syndrome; Pleural mesothelioma" "" "2" "0" "0.964" "0.915" "0.925" "1.042" "0.999" "0.926" "0.837" "0.888" "2.363" "246.0" "237.1" "225.0" "227.6" "256.3" "245.8" "227.7" "205.8" "218.4" "581.1" "" "" "" "" "" "" "" "" "" "" "221.1" "191.9" "203.5" "222.2" "211.5" "245.8" "170.5" "181.7" "195.4" "207.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3152037375536322199" "False" "High" "IsMasterProtein" "P68402" "Platelet-activating factor acetylhydrolase IB subunit alpha2 OS=Homo sapiens OX=9606 GN=PAFAH1B2 PE=1 SV=1" "0.000" "False" "9.105" "16" "3" "5" "3" "229" "25.6" "5.92" "13.50" "3" "other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13472" "5049" "ENSG00000168092" "PAFAH1B2" "A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; hsa:5049; O00687; P68402; Q29459; Q6IBR6" "PAFAH1B1 copy number variation" "Neutrophil degranulation; COPI-independent Golgi-to-ER retrograde traffic" "3" "0" "1.054" "0.845" "0.939" "1.203" "0.952" "1.103" "0.930" "1.098" "0.927" "110.2" "116.2" "93.1" "103.5" "132.6" "105.0" "121.5" "102.5" "121.1" "102.2" "" "" "" "" "" "" "" "" "" "" "99.1" "94.0" "84.2" "101.0" "109.4" "105.0" "91.0" "90.6" "108.3" "36.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4893836570063627970" "False" "High" "IsMasterProtein" "O75494" "Serine/arginine-rich splicing factor 10 OS=Homo sapiens OX=9606 GN=SRSF10 PE=1 SV=1" "0.000" "False" "9.087" "16" "4" "4" "4" "262" "31.3" "11.27" "8.33" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "10772" "ENSG00000188529" "SRSF10" "A6NFM6; A6NI42; A6NIU7; B4DJP9; hsa:10772; O60572; O75494; Q5JRH9; Q5JRI0; Q5JRI2; Q5JRI3; Q5JRI4; Q96G09; Q96P17" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5887664116474982474" "False" "High" "IsMasterProtein" "Q9H6E4" "Coiled-coil domain-containing protein 134 OS=Homo sapiens OX=9606 GN=CCDC134 PE=1 SV=1" "0.000" "False" "9.087" "15" "3" "3" "3" "229" "26.5" "8.85" "9.82" "3" "developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;nucleus;other cell component" "" "Pf15002" "79879" "ENSG00000100147" "CCDC134" "hsa:79879; Q9H6E4" "" "" "0" "0" "1.084" "1.105" "1.016" "1.039" "1.011" "0.973" "0.968" "0.931" "1.225" "94.5" "102.4" "104.5" "96.0" "98.2" "95.6" "92.0" "91.5" "88.0" "115.9" "" "" "" "" "" "" "" "" "" "" "85.0" "82.9" "94.5" "93.7" "81.1" "95.6" "68.9" "80.8" "78.7" "41.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7346476942521402077" "False" "High" "IsMasterProtein" "Q9BUT9" "MAPK regulated corepressor interacting protein 2 OS=Homo sapiens OX=9606 GN=MCRIP2 PE=1 SV=2" "0.000" "False" "9.084" "23" "2" "3" "2" "160" "17.8" "9.41" "13.45" "2" "" "nucleus;other cell component" "" "Pf14799" "84331" "ENSG00000172366" "MCRIP2" "hsa:84331; Q969E9; Q96KV8; Q9BUT9" "" "" "0" "0" "0.895" "0.900" "0.885" "0.947" "0.800" "0.943" "0.921" "0.846" "0.733" "151.8" "135.9" "136.6" "134.3" "143.7" "121.5" "143.1" "139.9" "128.4" "111.3" "" "" "" "" "" "" "" "" "" "" "136.5" "109.9" "123.6" "131.1" "118.6" "121.5" "107.2" "123.5" "114.9" "39.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1220366376593556815" "False" "High" "IsMasterProtein" "Q9Y5U2" "U5 small nuclear ribonucleoprotein TSSC4 OS=Homo sapiens OX=9606 GN=TSSC4 PE=1 SV=3" "0.000" "False" "9.077" "9" "3" "3" "3" "329" "34.3" "5.19" "9.20" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf15264" "10078" "ENSG00000184281" "TSSC4" "C9JS66; hsa:10078; Q86VL2; Q9BRS6; Q9Y5U2" "" "" "0" "0" "0.833" "0.818" "0.868" "0.977" "0.843" "0.899" "0.868" "0.817" "0.851" "138.7" "115.5" "113.5" "120.4" "135.5" "116.9" "124.6" "120.4" "113.2" "118.0" "" "" "" "" "" "" "" "" "" "" "124.7" "93.5" "102.7" "117.5" "111.8" "116.9" "93.3" "106.3" "101.3" "42.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6568070672358433938" "False" "High" "IsMasterProtein" "Q00341" "Vigilin OS=Homo sapiens OX=9606 GN=HDLBP PE=1 SV=3" "0.000" "False" "9.070" "2" "3" "3" "3" "1268" "141.4" "6.87" "9.63" "3" "other metabolic processes;transport" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013" "3069" "ENSG00000115677" "HDLBP" "B4DTQ2; E7EM71; hsa:3069; Q00341; Q53QU2; Q9UCY3" "2q37 copy number variation syndrome" "HDL clearance" "2" "0" "1.031" "1.114" "0.921" "0.941" "1.022" "1.041" "0.811" "1.040" "5.394" "284.7" "293.5" "317.2" "262.2" "267.9" "291.0" "296.4" "230.8" "296.2" "1535.6" "" "" "" "" "" "" "" "" "" "" "256.0" "237.5" "286.9" "255.9" "221.1" "291.0" "222.0" "203.8" "265.0" "548.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225000128541682863" "False" "High" "IsMasterProtein" "Q99836" "Myeloid differentiation primary response protein MyD88 OS=Homo sapiens OX=9606 GN=MYD88 PE=1 SV=1" "0.000" "False" "9.038" "11" "3" "3" "3" "296" "33.2" "6.15" "9.83" "3" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf13676" "4615" "ENSG00000172936" "MYD88" "B4DKH8; B4DKU4; B4DQ60; B4DQ72; hsa:4615; J3KPU4; J3KQ87; J3KQJ6; P78397; Q53XS7; Q99836" "IL-1 signaling pathway; AGE/RAGE pathway; Interleukin-1 (IL-1) structural pathway; IL1 and megakaryocytes in obesity; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; MYD88 distinct input-output pathway; Fibrin complement receptor 3 signaling pathway; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Measles virus infection; Hepatitis B infection; IL-18 signaling pathway; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; HDAC6 interactions in the central nervous system; Toll-like receptor signaling pathway" "PIP3 activates AKT signaling; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; ER-Phagosome pathway; Interleukin-1 signaling; MyD88:MAL(TIRAP) cascade initiated on plasma membrane; MyD88 deficiency (TLR2/4); IRAK4 deficiency (TLR2/4); RIP-mediated NFkB activation via ZBP1; p75NTR recruits signalling complexes; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation; MyD88 cascade initiated on plasma membrane; MyD88 deficiency (TLR5); IRAK4 deficiency (TLR5); TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "35" "0" "1.023" "1.071" "1.065" "1.107" "1.107" "1.073" "0.983" "1.185" "5.039" "205.7" "210.4" "220.4" "219.0" "227.6" "227.7" "220.8" "202.2" "243.7" "1036.3" "" "" "" "" "" "" "" "" "" "" "184.9" "170.2" "199.3" "213.8" "187.8" "227.7" "165.3" "178.6" "218.1" "369.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5769529800137255333" "False" "High" "IsMasterProtein" "O94817" "Ubiquitin-like protein ATG12 OS=Homo sapiens OX=9606 GN=ATG12 PE=1 SV=1" "0.000" "False" "9.014" "19" "3" "3" "3" "140" "15.1" "5.10" "11.26" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf04110" "9140" "ENSG00000145782" "ATG12" "hsa:9140; O94817; Q6PJV2" "Nanoparticle triggered autophagic cell death; Novel intracellular components of RIG-I-like receptor pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Cytosolic DNA-sensing pathway; Autophagy; Clock-controlled autophagy in bone metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy; Negative regulators of DDX58/IFIH1 signaling; PINK1-PRKN Mediated Mitophagy; Receptor Mediated Mitophagy" "11" "0" "0.929" "0.926" "1.000" "0.954" "0.938" "0.897" "0.986" "0.884" "1.271" "386.7" "359.1" "358.1" "386.7" "369.1" "362.9" "346.8" "381.4" "342.0" "491.6" "" "" "" "" "" "" "" "" "" "" "347.7" "290.6" "324.0" "377.5" "304.6" "362.9" "259.7" "336.9" "306.1" "175.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2041332710814858625" "False" "High" "IsMasterProtein" "Q9NRY4" "Rho GTPase-activating protein 35 OS=Homo sapiens OX=9606 GN=ARHGAP35 PE=1 SV=3" "0.000" "False" "9.003" "2" "3" "3" "3" "1499" "170.4" "6.64" "8.86" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00071, Pf00620, Pf16512, Pf19518" "2909" "ENSG00000160007" "ARHGAP35" "A7E2A4; hsa:2909; Q14452; Q9C0E1; Q9NRY4" "Focal adhesion; Regulation of actin cytoskeleton" "RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RND2 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RND3 GTPase cycle; RND1 GTPase cycle; Sema4D mediated inhibition of cell attachment and migration; PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases" "18" "0" "0.995" "1.257" "0.989" "0.974" "1.357" "0.999" "0.971" "1.058" "2.090" "146.7" "145.9" "184.4" "145.1" "142.9" "199.0" "146.5" "142.4" "155.1" "306.6" "" "" "" "" "" "" "" "" "" "" "131.9" "118.1" "166.8" "141.6" "117.9" "199.0" "109.7" "125.8" "138.8" "109.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330094663577244460" "False" "High" "IsMasterProtein" "Q13049" "E3 ubiquitin-protein ligase TRIM32 OS=Homo sapiens OX=9606 GN=TRIM32 PE=1 SV=2" "0.000" "False" "9.001" "5" "3" "3" "3" "653" "71.9" "6.98" "11.19" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf01436, Pf13445" "22954" "ENSG00000119401" "TRIM32" "hsa:22954; Q13049; Q9NQP8" "Ciliopathies; Bardet-Biedl syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of innate immune responses to cytosolic DNA" "4" "0" "0.997" "0.937" "1.023" "1.034" "1.152" "1.003" "0.902" "1.016" "1.559" "93.0" "92.8" "87.2" "95.2" "96.2" "107.2" "93.3" "83.9" "94.5" "145.0" "" "" "" "" "" "" "" "" "" "" "83.6" "75.1" "78.9" "92.9" "79.4" "107.2" "69.9" "74.1" "84.6" "51.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9138201817175006021" "False" "High" "IsMasterProtein" "Q96NL8" "Cilia- and flagella-associated protein 418 OS=Homo sapiens OX=9606 GN=CFAP418 PE=1 SV=1" "0.000" "False" "8.995" "15" "3" "3" "3" "207" "23.4" "6.95" "9.82" "3" "developmental processes" "plasma membrane;other membranes;cytosol;other cell component" "" "Pf14996" "157657" "ENSG00000156172" "CFAP418" "F4Y588; hsa:157657; Q96NL8" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "0.916" "0.840" "0.973" "0.801" "0.943" "0.843" "0.943" "1.002" "0.884" "119.3" "109.4" "100.2" "116.2" "95.6" "112.5" "100.5" "112.5" "119.6" "105.5" "" "" "" "" "" "" "" "" "" "" "107.3" "88.5" "90.6" "113.4" "78.9" "112.5" "75.3" "99.4" "107.0" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6251688870276858346" "False" "High" "IsMasterProtein" "Q9BX40" "Protein LSM14 homolog B OS=Homo sapiens OX=9606 GN=LSM14B PE=1 SV=1" "0.000" "False" "8.986" "9" "3" "3" "3" "385" "42.0" "9.69" "9.58" "3" "other biological processes" "other cell component" "nucleic acid binding activity" "Pf09532, Pf12701" "149986" "ENSG00000149657" "LSM14B" "hsa:149986; Q6PFW8; Q96LH8; Q9BX40" "" "" "0" "0" "0.913" "0.845" "0.867" "1.024" "0.934" "0.931" "0.819" "0.892" "1.304" "95.0" "86.7" "80.3" "82.4" "97.4" "88.7" "88.4" "77.9" "84.8" "123.9" "" "" "" "" "" "" "" "" "" "" "85.5" "70.2" "72.6" "80.4" "80.3" "88.7" "66.2" "68.8" "75.9" "44.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4618404774181820652" "False" "High" "IsMasterProtein" "P57076" "Cilia- and flagella-associated protein 298 OS=Homo sapiens OX=9606 GN=CFAP298 PE=1 SV=1" "0.000" "False" "8.984" "14" "2" "2" "2" "290" "33.2" "7.44" "13.31" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf11069" "56683" "ENSG00000159079" "CFAP298" "hsa:56683; P57076; Q53FH0" "Ciliopathies" "" "1" "0" "0.939" "0.850" "0.674" "0.964" "0.702" "1.202" "0.725" "0.929" "4.001" "16.6" "15.6" "14.1" "11.2" "16.0" "11.7" "20.0" "12.1" "15.4" "66.6" "" "" "" "" "" "" "" "" "" "" "15.0" "12.6" "12.8" "10.9" "13.2" "11.7" "15.0" "10.7" "13.8" "23.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1530625692360911706" "False" "High" "IsMasterProtein" "Q8IWB7" "WD repeat and FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=WDFY1 PE=1 SV=1" "0.000" "False" "8.979" "8" "3" "3" "3" "410" "46.3" "7.33" "11.35" "3" "other biological processes" "cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf01363" "57590" "ENSG00000085449" "WDFY1" "hsa:57590; Q53S17; Q8IWB7; Q9H9D5; Q9P2B3" "" "" "0" "0" "1.037" "0.947" "1.081" "1.051" "0.925" "1.100" "0.982" "1.001" "0.698" "309.2" "320.5" "292.8" "334.2" "325.0" "286.1" "340.3" "303.5" "309.5" "216.0" "" "" "" "" "" "" "" "" "" "" "278.0" "259.4" "264.8" "326.2" "268.2" "286.1" "254.8" "268.1" "277.0" "77.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6381027269296732412" "False" "High" "IsMasterProtein" "Q7Z392" "Trafficking protein particle complex subunit 11 OS=Homo sapiens OX=9606 GN=TRAPPC11 PE=1 SV=2" "0.000" "False" "8.977" "4" "4" "4" "4" "1133" "128.8" "7.14" "11.58" "4" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;other cell component" "" "Pf11817, Pf12742" "60684" "ENSG00000168538" "TRAPPC11" "A4QPB8; B2RCD6; hsa:60684; Q5U5I7; Q6FI73; Q7Z392; Q86T25; Q9H0L1; Q9H5K9; Q9H8Q1; Q9H9I7" "Genes related to primary cilium development (based on CRISPR)" "RAB GEFs exchange GTP for GDP on RABs" "2" "0" "1.075" "0.988" "1.147" "1.075" "0.920" "1.083" "1.180" "0.979" "1.315" "45.5" "48.9" "45.0" "52.3" "49.0" "41.9" "49.3" "53.7" "44.6" "59.9" "" "" "" "" "" "" "" "" "" "" "41.0" "39.6" "40.7" "51.0" "40.4" "41.9" "36.9" "47.5" "39.9" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6116188343313863326" "False" "High" "IsMasterProtein" "Q6P1L8" "Large ribosomal subunit protein uL14m OS=Homo sapiens OX=9606 GN=MRPL14 PE=1 SV=1" "0.000" "False" "8.963" "11" "2" "3" "2" "145" "15.9" "10.24" "9.40" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00238" "64928" "ENSG00000180992" "MRPL14" "B2R575; hsa:64928; Q6P1L8; Q96Q72" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.979" "0.913" "0.848" "0.929" "0.939" "0.935" "0.940" "0.934" "1.038" "446.4" "436.9" "407.8" "378.5" "414.7" "419.4" "417.2" "419.5" "416.8" "463.2" "" "" "" "" "" "" "" "" "" "" "401.4" "353.5" "368.8" "369.4" "342.2" "419.4" "312.4" "370.5" "373.0" "165.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6091940501454683011" "False" "High" "IsMasterProtein" "Q9UNX4" "WD repeat-containing protein 3 OS=Homo sapiens OX=9606 GN=WDR3 PE=1 SV=1" "0.000" "False" "8.954" "3" "4" "4" "4" "943" "106.0" "6.64" "8.08" "4" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf04003, Pf12894" "10885" "ENSG00000065183" "WDR3" "hsa:10885; Q9UNX4" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3047103662304523242" "False" "High" "IsMasterProtein" "Q9ULD9" "Zinc finger protein 608 OS=Homo sapiens OX=9606 GN=ZNF608 PE=1 SV=4" "0.000" "False" "8.941" "2" "3" "4" "2" "1512" "162.1" "8.79" "11.34" "3" "other biological processes" "nucleus" "other molecular function" "" "57507" "ENSG00000168916" "ZNF608" "A7E2W9; hsa:57507; Q3SYM6; Q68D12; Q8IY05; Q9ULD9; Q9Y5A1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-421733537835387635" "False" "High" "IsMasterProtein" "Q9NPE2" "Neugrin OS=Homo sapiens OX=9606 GN=NGRN PE=1 SV=2" "0.000" "False" "8.909" "11" "2" "2" "2" "291" "32.4" "9.10" "9.02" "2" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf06413" "51335" "ENSG00000182768" "NGRN" "B2R6M8; hsa:51335; Q4V9L7; Q9HBL4; Q9NPE2" "" "" "0" "0" "1.005" "0.993" "1.092" "1.140" "1.069" "1.030" "1.084" "1.056" "0.954" "181.0" "182.0" "179.7" "197.7" "206.4" "193.4" "186.5" "196.3" "191.1" "172.7" "" "" "" "" "" "" "" "" "" "" "162.8" "147.2" "162.6" "193.0" "170.3" "193.4" "139.6" "173.4" "171.0" "61.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8335740267375587213" "False" "High" "IsMasterProtein" "P09132" "Signal recognition particle 19 kDa protein OS=Homo sapiens OX=9606 GN=SRP19 PE=1 SV=3" "0.000" "False" "8.906" "10" "1" "3" "1" "144" "16.1" "9.85" "11.14" "1" "cell organization and biogenesis;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity" "Pf01922" "6728" "ENSG00000153037" "SRP19" "B2R4E9; D6RCQ5; hsa:6728; P09132; Q05D77; Q96FG6" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "0.872" "0.861" "0.926" "1.010" "0.919" "0.991" "1.002" "0.902" "0.902" "266.2" "232.0" "229.3" "246.6" "268.8" "244.7" "263.6" "266.8" "240.1" "240.0" "" "" "" "" "" "" "" "" "" "" "239.3" "187.8" "207.4" "240.7" "221.8" "244.7" "197.4" "235.7" "214.9" "85.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1549161421235899806" "False" "High" "IsMasterProtein" "Q96EH3" "Mitochondrial assembly of ribosomal large subunit protein 1 OS=Homo sapiens OX=9606 GN=MALSU1 PE=1 SV=1" "0.000" "False" "8.884" "18" "3" "4" "3" "234" "26.2" "5.49" "13.85" "3" "other biological processes" "cytosol;mitochondrion" "translation activity" "Pf02410" "115416" "ENSG00000156928" "MALSU1" "A4D154; hsa:115416; Q96EH3" "" "" "0" "0" "0.923" "0.994" "0.990" "1.095" "1.036" "0.953" "1.090" "1.120" "0.855" "397.7" "367.1" "395.2" "393.8" "435.5" "412.2" "379.2" "433.6" "445.4" "339.9" "" "" "" "" "" "" "" "" "" "" "357.6" "297.1" "357.5" "384.4" "359.4" "412.2" "284.0" "382.9" "398.6" "121.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1523166315396082647" "False" "High" "IsMasterProtein" "P27815" "3',5'-cyclic-AMP phosphodiesterase 4A OS=Homo sapiens OX=9606 GN=PDE4A PE=1 SV=3" "0.000" "False" "8.872" "3" "2" "2" "2" "886" "98.1" "5.21" "7.86" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00233, Pf18100" "5141" "ENSG00000065989" "PDE4A" "hsa:5141; O75522; O76092; P27815; Q16255; Q16691; Q5DM53; Q6PMT2; Q8IVA7; Q8WUQ3; Q9H3H2" "G protein signaling pathways; Phosphodiesterases in neuronal function; Sildenafil treatment" "G alpha (s) signalling events; DARPP-32 events" "5" "0" "1.150" "0.952" "1.172" "1.251" "1.170" "1.105" "1.148" "0.991" "0.766" "65.0" "74.8" "62.0" "76.3" "81.4" "76.1" "71.8" "74.6" "64.4" "49.8" "" "" "" "" "" "" "" "" "" "" "58.5" "60.5" "56.0" "74.4" "67.2" "76.1" "53.8" "65.9" "57.7" "17.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983713321704176407" "False" "High" "IsMasterProtein" "O00264" "Membrane-associated progesterone receptor component 1 OS=Homo sapiens OX=9606 GN=PGRMC1 PE=1 SV=3" "0.000" "False" "8.871" "13" "4" "5" "4" "195" "21.7" "4.70" "15.35" "4" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;mitochondrion;ER/Golgi;other cell component" "other molecular function" "Pf00173" "10857" "ENSG00000101856" "PGRMC1" "B7Z1L3; hsa:10857; O00264; Q9UGJ9" "Primary ovarian insufficiency" "Neutrophil degranulation" "2" "0" "0.965" "0.935" "0.913" "0.992" "0.955" "0.991" "0.961" "0.951" "0.783" "412.7" "398.4" "385.9" "377.0" "409.6" "394.0" "409.1" "396.5" "392.4" "323.2" "" "" "" "" "" "" "" "" "" "" "371.1" "322.4" "349.0" "368.0" "338.0" "394.0" "306.4" "350.3" "351.1" "115.4" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8876703773954477578" "False" "High" "IsMasterProtein" "O43759" "Synaptogyrin-1 OS=Homo sapiens OX=9606 GN=SYNGR1 PE=1 SV=2" "0.000" "False" "8.856" "10" "2" "2" "2" "233" "25.4" "4.68" "9.27" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf01284" "9145" "ENSG00000100321" "SYNGR1" "A6NP69; A8K0E2; hsa:9145; O43757; O43758; O43759; Q53Y02; Q96J56; Q9UGZ4" "" "Neutrophil degranulation" "1" "0" "1.057" "0.984" "0.968" "1.060" "0.924" "1.012" "1.127" "1.054" "0.955" "262.8" "277.8" "258.5" "254.5" "278.4" "242.8" "265.9" "296.1" "276.8" "250.9" "" "" "" "" "" "" "" "" "" "" "236.2" "224.8" "233.8" "248.4" "229.8" "242.8" "199.1" "261.6" "247.7" "89.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5573084200900719321" "False" "High" "IsMasterProtein" "Q9Y5V0" "Zinc finger protein 706 OS=Homo sapiens OX=9606 GN=ZNF706 PE=1 SV=1" "0.000" "False" "8.841" "32" "3" "6" "3" "76" "8.5" "10.01" "16.41" "3" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf04419, Pf12874" "51123" "ENSG00000120963" "ZNF706" "A8K362; hsa:51123; Q9Y5V0" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7498907094133803237" "False" "High" "IsMasterProtein" "A4D1P6" "WD repeat-containing protein 91 OS=Homo sapiens OX=9606 GN=WDR91 PE=1 SV=2" "0.000" "False" "8.833" "4" "3" "3" "3" "747" "83.3" "6.58" "5.23" "3" "transport;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00400, Pf12894" "29062" "ENSG00000105875" "WDR91" "A4D1P6; A6NK54; C9JMI4; hsa:29062; Q6FI65; Q6MZQ1; Q6P4I1; Q96AE5; Q96G63; Q9H062; Q9H9B6; Q9NVG7; Q9NZY6" "" "CDC42 GTPase cycle" "1" "0" "0.982" "1.062" "1.008" "1.044" "1.059" "1.182" "1.064" "1.083" "1.409" "153.2" "150.5" "162.6" "154.4" "159.9" "162.2" "181.0" "163.0" "165.9" "215.8" "" "" "" "" "" "" "" "" "" "" "137.7" "121.8" "147.1" "150.7" "132.0" "162.2" "135.5" "144.0" "148.5" "77.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6200383293614890998" "False" "High" "IsMasterProtein" "Q9UK45" "U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens OX=9606 GN=LSM7 PE=1 SV=1" "0.000" "False" "8.831" "22" "3" "9" "2" "103" "11.6" "5.27" "24.35" "3" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "51690" "ENSG00000130332" "LSM7" "hsa:51690; Q9UK45" "mRNA processing" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "3" "0" "0.919" "0.981" "0.983" "1.008" "1.054" "0.939" "1.090" "1.017" "0.828" "528.4" "485.7" "518.2" "519.4" "532.4" "557.0" "496.0" "576.0" "537.2" "437.7" "" "" "" "" "" "" "" "" "" "" "475.1" "393.0" "468.8" "507.0" "439.3" "557.0" "371.4" "508.8" "480.7" "156.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635487615117841616" "False" "High" "IsMasterProtein" "Q7Z3E2" "Coiled-coil domain-containing protein 186 OS=Homo sapiens OX=9606 GN=CCDC186 PE=1 SV=2" "0.000" "False" "8.827" "3" "3" "3" "3" "898" "103.6" "6.27" "11.05" "3" "cell-cell signaling;transport;other biological processes" "ER/Golgi" "other molecular function" "" "55088" "ENSG00000165813" "CCDC186" "hsa:55088; Q2M2V6; Q3ZB81; Q6NS91; Q7RTP1; Q7Z3E2; Q8N117; Q8N3G3; Q8N6C2; Q9NWA3" "" "" "0" "0" "1.021" "0.985" "0.879" "1.072" "1.000" "1.076" "0.978" "1.041" "1.196" "343.0" "350.2" "338.0" "301.6" "367.6" "343.2" "368.9" "335.4" "357.0" "410.1" "" "" "" "" "" "" "" "" "" "" "308.4" "283.3" "305.7" "294.4" "303.3" "343.2" "276.2" "296.3" "319.5" "146.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6341136208215643454" "False" "High" "IsMasterProtein" "Q6GYQ0" "Ral GTPase-activating protein subunit alpha-1 OS=Homo sapiens OX=9606 GN=RALGAPA1 PE=1 SV=1" "0.000" "False" "8.822" "2" "3" "3" "3" "2036" "229.7" "6.19" "8.65" "3" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "253959" "ENSG00000174373" "RALGAPA1" "A6NMA4; B9EK38; C5NU19; hsa:253959; O94960; Q6GYP9; Q6GYQ0; Q6ZT23; Q86YF3; Q86YF5; Q8ND69" "" "RHOH GTPase cycle" "1" "0" "1.217" "1.143" "0.992" "1.234" "1.207" "1.178" "1.044" "1.136" "0.790" "50.8" "61.8" "58.0" "50.4" "62.6" "61.3" "59.8" "53.0" "57.7" "40.1" "" "" "" "" "" "" "" "" "" "" "45.7" "50.0" "52.5" "49.2" "51.7" "61.3" "44.8" "46.8" "51.6" "14.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1650910315331199742" "False" "High" "IsMasterProtein" "Q9NZA1" "Chloride intracellular channel protein 5 OS=Homo sapiens OX=9606 GN=CLIC5 PE=1 SV=3" "0.000" "False" "8.813" "4" "1" "3" "1" "410" "46.5" "4.82" "9.12" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion;ER/Golgi;other cell component" "transporter activity" "Pf13409, Pf13410" "53405" "ENSG00000112782" "CLIC5" "B3KUF1; hsa:53405; Q5T4Z0; Q8NBY3; Q96JT5; Q9BWZ0; Q9NZA1" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "0.931" "0.914" "0.877" "1.044" "0.918" "1.094" "0.977" "0.985" "0.922" "379.0" "352.8" "346.3" "332.2" "395.9" "347.9" "414.7" "370.2" "373.5" "349.6" "" "" "" "" "" "" "" "" "" "" "340.8" "285.4" "313.2" "324.3" "326.7" "347.9" "310.5" "327.0" "334.2" "124.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3071770870623054181" "False" "High" "IsMasterProtein" "Q8N442" "Translation factor GUF1, mitochondrial OS=Homo sapiens OX=9606 GN=GUF1 PE=1 SV=1" "0.000" "False" "8.813" "4" "3" "3" "3" "669" "74.3" "8.59" "10.01" "3" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "translation activity;other molecular function" "Pf00009, Pf00679, Pf03144, Pf06421" "60558" "ENSG00000151806" "GUF1" "hsa:60558; Q5XKM8; Q8N442; Q9H710; Q9H8U4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3318017659961933117" "False" "High" "IsMasterProtein" "Q9NVA1" "Ubiquinol-cytochrome c reductase complex assembly factor 1 OS=Homo sapiens OX=9606 GN=UQCC1 PE=1 SV=3" "0.000" "False" "8.748" "7" "2" "3" "2" "299" "34.6" "8.91" "7.76" "2" "cell organization and biogenesis" "other membranes;mitochondrion;other cell component" "" "Pf03981" "55245" "ENSG00000101019" "UQCC1" "B1AKV5; hsa:55245; Q0VF37; Q5T348; Q5T351; Q5T353; Q86YU3; Q86YU4; Q96H66; Q9H438; Q9H452; Q9H9K8; Q9H9R5; Q9NVA1" "Ciliary landscape; Mitochondrial complex III assembly" "" "2" "0" "0.967" "1.282" "1.033" "1.192" "1.048" "0.992" "1.023" "1.148" "1.039" "127.4" "123.2" "163.3" "131.7" "151.9" "133.5" "126.3" "130.4" "146.3" "132.4" "" "" "" "" "" "" "" "" "" "" "114.5" "99.7" "147.7" "128.5" "125.4" "133.5" "94.6" "115.2" "130.9" "47.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7381193083052724868" "False" "High" "IsMasterProtein" "Q9Y6R4" "Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2" "0.000" "False" "8.743" "2" "4" "4" "4" "1608" "181.6" "6.32" "12.27" "4" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other cell component" "kinase activity;other molecular function" "Pf00069, Pf19431" "4216" "ENSG00000085511" "MAP3K4" "A6H8W0; B7ZLD3; B9EG75; hsa:4216; Q5VTT8; Q5VTT9; Q92612; Q9H408; Q9Y6R4" "MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Insulin signaling; MAP3K1 role in promoting and blocking gonadal determination; Host-pathogen interaction of human coronaviruses - MAPK signaling; Pleural mesothelioma; G13 signaling pathway; DNA damage response (only ATM dependent)" "" "9" "0" "1.062" "1.118" "0.953" "1.051" "1.016" "1.025" "0.978" "0.972" "1.387" "405.7" "431.1" "453.4" "386.9" "426.3" "412.1" "415.8" "396.8" "394.5" "562.7" "" "" "" "" "" "" "" "" "" "" "364.8" "348.8" "410.2" "377.6" "351.8" "412.1" "311.4" "350.4" "353.0" "200.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7421726054682487966" "False" "High" "IsMasterProtein" "Q9NX18" "Succinate dehydrogenase assembly factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF2 PE=1 SV=1" "0.000" "False" "8.741" "19" "3" "3" "3" "166" "19.6" "6.80" "8.96" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus" "" "Pf03937" "54949" "ENSG00000167985" "SDHAF2" "hsa:54949; Q9NX18" "Mitochondrial complex II assembly" "" "1" "0" "1.123" "1.295" "1.137" "1.108" "1.269" "1.061" "1.240" "1.412" "0.969" "120.8" "135.7" "156.5" "137.4" "133.9" "153.3" "128.2" "149.8" "170.6" "117.1" "" "" "" "" "" "" "" "" "" "" "108.6" "109.8" "141.6" "134.1" "110.5" "153.3" "96.0" "132.3" "152.7" "41.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2419362748715144783" "False" "High" "IsMasterProtein" "Q0VG06" "Fanconi anemia core complex-associated protein 100 OS=Homo sapiens OX=9606 GN=FAAP100 PE=1 SV=3" "0.000" "False" "8.741" "3" "2" "3" "2" "881" "93.4" "5.29" "8.75" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf15146" "80233" "ENSG00000185504" "FAAP100" "A6NNM1; hsa:80233; Q0VG06; Q8N3F7; Q9BV13; Q9H6K7; Q9H7E8" "DNA repair pathways, full network" "Fanconi Anemia Pathway; PKR-mediated signaling" "3" "0" "1.267" "1.012" "0.948" "1.080" "1.107" "1.017" "0.968" "1.065" "1.148" "37.6" "47.6" "38.1" "35.6" "40.6" "41.6" "38.2" "36.4" "40.0" "43.1" "" "" "" "" "" "" "" "" "" "" "33.8" "38.5" "34.4" "34.8" "33.5" "41.6" "28.6" "32.1" "35.8" "15.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4521329794053270042" "False" "High" "IsMasterProtein" "Q66K64" "DDB1- and CUL4-associated factor 15 OS=Homo sapiens OX=9606 GN=DCAF15 PE=1 SV=1" "0.000" "False" "8.740" "5" "3" "3" "3" "600" "66.4" "6.58" "9.34" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf14939" "90379" "ENSG00000132017; ENSG00000288453" "DCAF15" "B3KS86; hsa:90379; Q66K64; Q96DW0; Q9BU31" "" "" "0" "0" "1.327" "1.426" "1.144" "1.456" "1.056" "1.563" "1.204" "1.360" "0.731" "22.7" "30.1" "32.4" "26.0" "33.0" "24.0" "35.5" "27.3" "30.9" "16.6" "" "" "" "" "" "" "" "" "" "" "20.4" "24.4" "29.3" "25.4" "27.3" "24.0" "26.6" "24.1" "27.6" "5.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4534068984681137235" "False" "High" "IsMasterProtein" "Q86WQ0" "Nuclear receptor 2C2-associated protein OS=Homo sapiens OX=9606 GN=NR2C2AP PE=1 SV=1" "0.000" "False" "8.681" "26" "2" "4" "2" "139" "15.9" "6.16" "17.13" "2" "" "nucleus" "" "" "126382" "ENSG00000184162" "NR2C2AP" "A6NGP7; B4DW92; hsa:126382; Q86WQ0" "" "Nuclear Receptor transcription pathway" "1" "0" "1.095" "1.036" "1.004" "1.142" "1.055" "1.060" "1.055" "1.027" "0.821" "242.8" "265.9" "251.5" "243.7" "277.2" "256.2" "257.3" "256.0" "249.2" "199.2" "" "" "" "" "" "" "" "" "" "" "218.3" "215.1" "227.5" "237.9" "228.8" "256.2" "192.7" "226.1" "223.0" "71.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7462981975688921114" "False" "High" "IsMasterProtein" "Q7Z2T5" "TRMT1-like protein OS=Homo sapiens OX=9606 GN=TRMT1L PE=1 SV=2" "0.000" "False" "8.675" "2" "1" "2" "1" "733" "81.7" "7.88" "10.47" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02005" "81627" "ENSG00000121486" "TRMT1L" "hsa:81627; Q5TEN0; Q6ZMX0; Q7Z2T5; Q8IWH5; Q8NC68; Q9BZQ1" "" "" "0" "0" "0.952" "0.772" "0.745" "0.987" "1.122" "0.838" "0.732" "0.692" "0.939" "38.2" "36.4" "29.5" "28.5" "37.7" "42.9" "32.0" "28.0" "26.5" "35.9" "" "" "" "" "" "" "" "" "" "" "34.4" "29.4" "26.7" "27.8" "31.1" "42.9" "24.0" "24.7" "23.7" "12.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5986646952840969808" "False" "High" "IsMasterProtein" "Q9BUE6" "Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=ISCA1 PE=1 SV=1" "0.000" "False" "8.662" "22" "2" "2" "2" "129" "14.2" "9.07" "8.70" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf01521" "81689" "ENSG00000135070" "ISCA1" "B3KP34; B4DJI5; hsa:81689; Q8ND75; Q9BUE6; Q9BZR2" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "0.805" "1.043" "0.868" "1.021" "0.892" "0.935" "0.880" "0.889" "0.789" "117.5" "94.6" "122.6" "102.0" "120.0" "104.8" "109.9" "103.4" "104.5" "92.8" "" "" "" "" "" "" "" "" "" "" "105.7" "76.6" "110.9" "99.5" "99.1" "104.8" "82.3" "91.3" "93.5" "33.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225180490638560304" "False" "High" "IsMasterProtein" "P51157" "Ras-related protein Rab-28 OS=Homo sapiens OX=9606 GN=RAB28 PE=1 SV=2" "0.000" "False" "8.660" "13" "3" "3" "3" "221" "24.8" "5.97" "10.44" "3" "transport" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00071" "9364" "ENSG00000157869" "RAB28" "G8JLC5; hsa:9364; P51157; Q8IYR8; Q8NI05" "Ciliopathies" "" "1" "0" "1.102" "1.010" "1.007" "1.202" "1.153" "1.093" "1.101" "1.087" "1.094" "150.7" "166.0" "152.1" "151.8" "181.1" "173.7" "164.7" "165.8" "163.8" "164.8" "" "" "" "" "" "" "" "" "" "" "135.5" "134.3" "137.6" "148.1" "149.4" "173.7" "123.3" "146.5" "146.5" "58.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "717271239892975644" "False" "High" "IsMasterProtein" "Q9UK73" "Protein fem-1 homolog B OS=Homo sapiens OX=9606 GN=FEM1B PE=1 SV=1" "0.000" "False" "8.659" "5" "3" "3" "3" "627" "70.2" "6.61" "8.88" "3" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf12796" "10116" "ENSG00000169018" "FEM1B" "hsa:10116; O43146; Q9UK73" "" "Neddylation" "1" "0" "1.185" "0.958" "0.867" "1.158" "1.122" "1.154" "1.053" "0.970" "0.975" "159.1" "188.5" "152.4" "137.9" "184.3" "178.5" "183.5" "167.6" "154.4" "155.2" "" "" "" "" "" "" "" "" "" "" "143.0" "152.6" "137.8" "134.6" "152.1" "178.5" "137.4" "148.0" "138.1" "55.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8048887560610190463" "False" "High" "IsMasterProtein" "Q5JPH6" "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial OS=Homo sapiens OX=9606 GN=EARS2 PE=1 SV=2" "0.000" "False" "8.656" "7" "3" "3" "3" "523" "58.7" "8.76" "9.71" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00749, Pf19269" "124454" "ENSG00000103356" "EARS2" "B3KTT2; D3DWF1; hsa:124454; Q5JPH6; Q86YH3; Q8TF31" "" "Mitochondrial tRNA aminoacylation" "1" "0" "1.122" "1.161" "1.131" "1.054" "1.102" "0.981" "1.196" "1.139" "3.939" "93.5" "104.9" "108.6" "105.8" "98.6" "103.1" "91.8" "111.9" "106.5" "368.5" "" "" "" "" "" "" "" "" "" "" "84.1" "84.9" "98.2" "103.3" "81.4" "103.1" "68.7" "98.8" "95.3" "131.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3196363809325094679" "False" "High" "IsMasterProtein" "Q9HCU8" "DNA polymerase delta subunit 4 OS=Homo sapiens OX=9606 GN=POLD4 PE=1 SV=1" "0.000" "False" "8.644" "23" "2" "2" "2" "107" "12.4" "6.77" "9.75" "2" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "" "Pf04081" "57804" "ENSG00000175482" "POLD4" "F5H506; hsa:57804; Q9HCU8" "Homologous recombination; Pyrimidine metabolism; DNA replication; Base excision repair; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; DNA mismatch repair" "Polymerase switching on the C-strand of the telomere; Polymerase switching; Removal of the Flap Intermediate; HDR through Homologous Recombination (HRR); Termination of translesion DNA synthesis; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Recognition of DNA damage by PCNA-containing replication complex; PCNA-Dependent Long Patch Base Excision Repair; Dual Incision in GG-NER; Gap-filling DNA repair synthesis and ligation in GG-NER; Removal of the Flap Intermediate from the C-strand; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)" "25" "0" "1.062" "0.436" "1.031" "1.228" "0.665" "1.106" "1.143" "0.539" "0.806" "295.9" "314.1" "129.1" "304.9" "363.5" "196.7" "327.1" "338.2" "159.6" "238.4" "" "" "" "" "" "" "" "" "" "" "266.0" "254.2" "116.8" "297.7" "299.9" "196.7" "244.9" "298.7" "142.8" "85.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4562553461680680521" "False" "High" "IsMasterProtein" "Q9Y2Q5" "Ragulator complex protein LAMTOR2 OS=Homo sapiens OX=9606 GN=LAMTOR2 PE=1 SV=1" "0.000" "False" "8.641" "19" "2" "3" "2" "125" "13.5" "5.40" "6.47" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf03259" "28956" "ENSG00000116586" "LAMTOR2" "hsa:28956; Q5VY97; Q5VY98; Q5VY99; Q9Y2Q5" "" "Neutrophil degranulation; Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK; MAP2K and MAPK activation" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7506213950327089282" "False" "High" "IsMasterProtein" "Q8IUF8" "Ribosomal oxygenase 2 OS=Homo sapiens OX=9606 GN=RIOX2 PE=1 SV=1" "0.000" "False" "8.638" "6" "3" "4" "3" "465" "52.8" "6.70" "12.42" "3" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf08007, Pf20514" "84864" "ENSG00000170854" "RIOX2" "D3DN35; Q6AHW4; Q6SKS0; Q8IU69; Q8IUF6; Q8IUF7; Q8IUF8; Q96C17; Q96KB0" "" "Protein hydroxylation; HDMs demethylate histones" "2" "0" "0.932" "1.073" "0.824" "0.916" "1.104" "0.952" "0.944" "0.911" "1.042" "237.3" "221.2" "254.6" "195.4" "217.4" "261.9" "225.9" "224.1" "216.1" "247.2" "" "" "" "" "" "" "" "" "" "" "213.3" "179.0" "230.3" "190.7" "179.4" "261.9" "169.2" "197.9" "193.4" "88.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1867666717425813757" "False" "High" "IsMasterProtein" "Q8IXM2" "Chromatin complexes subunit BAP18 OS=Homo sapiens OX=9606 GN=BAP18 PE=1 SV=1" "0.000" "False" "8.620" "17" "2" "2" "2" "172" "17.9" "7.33" "10.11" "2" "cell organization and biogenesis" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "" "124944" "ENSG00000258315" "BAP18" "B4DIV3; C9J4G0; E9PB29; hsa:124944; Q8IXM2" "" "" "0" "0" "0.967" "0.861" "1.051" "1.025" "0.959" "1.020" "0.972" "0.930" "1.035" "196.3" "189.8" "168.9" "206.3" "201.3" "188.1" "200.2" "190.8" "182.5" "203.2" "" "" "" "" "" "" "" "" "" "" "176.5" "153.5" "152.8" "201.4" "166.1" "188.1" "149.9" "168.6" "163.3" "72.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1940412608894295944" "False" "High" "IsMasterProtein" "Q6P9B6" "MTOR-associated protein MEAK7 OS=Homo sapiens OX=9606 GN=MEAK7 PE=1 SV=2" "0.000" "False" "8.617" "5" "2" "3" "2" "456" "51.0" "6.24" "9.21" "2" "signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07534" "57707" "ENSG00000140950" "MEAK7" "hsa:57707; Q6P9B6; Q8IZ64; Q9HCG3; Q9NTE8" "" "" "0" "0" "1.061" "1.148" "0.997" "1.119" "0.912" "0.951" "1.135" "1.087" "0.787" "90.2" "95.7" "103.6" "89.9" "100.9" "82.3" "85.8" "102.4" "98.0" "70.9" "" "" "" "" "" "" "" "" "" "" "81.1" "77.4" "93.7" "87.8" "83.3" "82.3" "64.2" "90.4" "87.7" "25.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "282539810863181563" "False" "High" "IsMasterProtein" "Q9UL40" "Zinc finger protein 346 OS=Homo sapiens OX=9606 GN=ZNF346 PE=1 SV=1" "0.000" "False" "8.614" "7" "2" "4" "2" "294" "32.9" "9.09" "10.44" "2" "" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12874" "23567" "ENSG00000113761" "ZNF346" "B7Z367; hsa:23567; Q68CV9; Q6ZMW1; Q9UL40" "5q35 copy number variation" "" "1" "0" "1.073" "1.018" "0.834" "1.039" "0.910" "1.052" "1.177" "1.029" "0.928" "84.1" "90.2" "85.6" "70.1" "87.3" "76.5" "88.4" "99.0" "86.5" "78.0" "" "" "" "" "" "" "" "" "" "" "75.6" "73.0" "77.4" "68.5" "72.0" "76.5" "66.2" "87.4" "77.4" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8485687817967320227" "False" "High" "IsMasterProtein" "Q96ES7" "SAGA-associated factor 29 OS=Homo sapiens OX=9606 GN=SGF29 PE=1 SV=1" "0.000" "False" "8.612" "8" "2" "2" "2" "293" "33.2" "8.10" "9.07" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07039" "112869" "ENSG00000176476" "SGF29" "hsa:112869; Q96ES7; Q96MF5" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "0.899" "0.868" "0.931" "1.022" "0.899" "0.993" "0.964" "0.852" "1.223" "316.6" "284.5" "274.7" "294.6" "323.5" "284.5" "314.3" "305.2" "269.6" "387.2" "" "" "" "" "" "" "" "" "" "" "284.6" "230.2" "248.5" "287.5" "267.0" "284.5" "235.3" "269.6" "241.3" "138.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3247337186477247949" "False" "High" "IsMasterProtein" "Q9UQR1" "Zinc finger protein 148 OS=Homo sapiens OX=9606 GN=ZNF148 PE=1 SV=2" "0.000" "False" "8.611" "4" "4" "4" "4" "794" "88.9" "6.48" "8.80" "4" "stress response;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7707" "ENSG00000163848" "ZNF148" "D3DN27; O00389; O43591; Q58EY5; Q6PJ98; Q9UQR1" "" "" "0" "0" "1.018" "0.980" "1.005" "0.987" "0.985" "1.044" "0.983" "0.921" "2.063" "449.3" "457.6" "440.2" "451.4" "443.7" "442.6" "469.3" "441.7" "413.7" "926.9" "" "" "" "" "" "" "" "" "" "" "404.0" "370.2" "398.1" "440.6" "366.1" "442.6" "351.4" "390.1" "370.1" "330.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-531095149826683174" "False" "High" "IsMasterProtein" "Q86WX3" "Active regulator of SIRT1 OS=Homo sapiens OX=9606 GN=RPS19BP1 PE=1 SV=1" "0.000" "False" "8.608" "29" "4" "4" "4" "136" "15.4" "10.74" "8.74" "4" "other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15684" "91582" "ENSG00000187051" "RPS19BP1" "B0QY96; hsa:91582; Q5JZA1; Q86WX3" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "0.973" "0.752" "0.959" "1.094" "0.859" "1.013" "1.022" "0.821" "0.821" "460.2" "447.8" "345.9" "441.4" "503.2" "395.5" "466.3" "470.1" "377.8" "377.8" "" "" "" "" "" "" "" "" "" "" "413.7" "362.3" "312.9" "430.8" "415.3" "395.5" "349.1" "415.3" "338.1" "134.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4232598259152992278" "False" "High" "IsMasterProtein" "Q86Y56" "Dynein axonemal assembly factor 5 OS=Homo sapiens OX=9606 GN=DNAAF5 PE=1 SV=4" "0.000" "False" "8.581" "3" "3" "3" "3" "855" "93.5" "6.42" "9.24" "3" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf02985" "54919" "ENSG00000164818" "DNAAF5" "hsa:54919; Q69YL1; Q86Y56; Q96FI9; Q9NX75" "Ciliopathies" "" "1" "0" "1.370" "1.321" "0.966" "1.059" "1.053" "1.215" "1.245" "1.246" "2.559" "26.8" "36.8" "35.4" "25.9" "28.4" "28.3" "32.6" "33.4" "33.4" "68.7" "" "" "" "" "" "" "" "" "" "" "24.1" "29.7" "32.1" "25.3" "23.4" "28.3" "24.4" "29.5" "29.9" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2426417921420304223" "False" "High" "IsMasterProtein" "Q13523" "Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens OX=9606 GN=PRP4K PE=1 SV=3" "0.000" "False" "8.558" "2" "3" "3" "3" "1007" "116.9" "10.26" "9.42" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8899" "ENSG00000112739" "PRPF4B" "A8K5C9; hsa:8899; Q13523; Q5D0F6; Q5TAY8; Q8IVC3; Q8TDP2; Q96QT7; Q9UEE6" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "300613952239317335" "False" "High" "IsMasterProtein" "O43766" "Lipoyl synthase, mitochondrial OS=Homo sapiens OX=9606 GN=LIAS PE=1 SV=3" "0.000" "False" "8.558" "9" "3" "3" "3" "372" "41.9" "8.59" "7.36" "3" "other metabolic processes;stress response;developmental processes;other biological processes" "mitochondrion" "other molecular function" "Pf04055, Pf16881" "11019" "ENSG00000121897" "LIAS" "A8K873; C9JCF6; hsa:11019; O43766; Q8IV62" "" "Glyoxylate metabolism and glycine degradation" "1" "0" "1.184" "0.842" "0.979" "1.024" "1.010" "0.925" "0.990" "0.865" "0.893" "243.9" "288.8" "205.3" "238.8" "249.8" "246.3" "225.7" "241.5" "210.9" "217.8" "" "" "" "" "" "" "" "" "" "" "219.2" "233.7" "185.7" "233.1" "206.1" "246.3" "169.0" "213.3" "188.8" "77.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3191297454369684242" "False" "High" "IsMasterProtein" "Q8WZ42" "Titin OS=Homo sapiens OX=9606 GN=TTN PE=1 SV=4" "0.000" "False" "8.545" "0" "5" "5" "3" "34350" "3813.7" "6.35" "11.13" "5" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity;kinase activity;other molecular function" "Pf00041, Pf00069, Pf02818, Pf07679, Pf09042, Pf18362" "7273" "ENSG00000155657" "TTN" "A6NKB1; E7EQE6; E7ET18; hsa:7273; K7ENY1; Q10465; Q10466; Q15598; Q2XUS3; Q32Q60; Q4U1Z6; Q4ZG20; Q6NSG0; Q6PDB1; Q6PJP0; Q7KYM2; Q7KYN4; Q7KYN5; Q7LDM3; Q7Z2X3; Q8TCG8; Q8WZ42; Q8WZ51; Q8WZ52; Q8WZ53; Q8WZB3; Q92761; Q92762; Q9UD97; Q9UP84; Q9Y6L9" "Striated muscle contraction pathway; Cardiomyocyte signaling pathways converging on titin" "Platelet degranulation ; Striated Muscle Contraction" "4" "0" "0.765" "0.953" "0.562" "0.606" "0.696" "0.696" "0.702" "0.618" "0.505" "445.6" "340.9" "424.7" "250.5" "270.0" "310.0" "310.1" "313.0" "275.2" "224.9" "" "" "" "" "" "" "" "" "" "" "400.6" "275.9" "384.2" "244.5" "222.8" "310.0" "232.2" "276.4" "246.2" "80.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-27127465578060112" "False" "High" "IsMasterProtein" "Q96SU4" "Oxysterol-binding protein-related protein 9 OS=Homo sapiens OX=9606 GN=OSBPL9 PE=1 SV=2" "0.000" "False" "8.535" "4" "3" "3" "3" "736" "83.1" "6.18" "10.75" "3" "other metabolic processes;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114883" "ENSG00000117859" "OSBPL9" "B1AKJ8; B3KPQ4; D3DQ31; hsa:114883; Q5TFC0; Q6IA67; Q86YQ3; Q8NB17; Q8TAS8; Q96SK4; Q96SU4; Q9H9X2" "" "Synthesis of bile acids and bile salts" "1" "0" "0.974" "1.149" "0.860" "0.910" "0.998" "1.091" "0.899" "0.926" "6.989" "199.3" "194.2" "228.9" "171.5" "181.4" "198.9" "217.3" "179.1" "184.5" "1392.8" "" "" "" "" "" "" "" "" "" "" "179.2" "157.2" "207.1" "167.4" "149.7" "198.9" "162.7" "158.2" "165.1" "497.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785225310514612646" "False" "High" "IsMasterProtein" "Q9NZ45" "CDGSH iron-sulfur domain-containing protein 1 OS=Homo sapiens OX=9606 GN=CISD1 PE=1 SV=1" "0.000" "False" "8.534" "26" "2" "2" "2" "108" "12.2" "9.09" "7.86" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf09360, Pf10660" "55847" "ENSG00000122873" "CISD1" "hsa:55847; Q1X902; Q9NZ45" "Adipogenesis; Ferroptosis" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1899835700088576048" "False" "High" "IsMasterProtein" "O14656" "Torsin-1A OS=Homo sapiens OX=9606 GN=TOR1A PE=1 SV=1" "0.000" "False" "8.516" "6" "2" "2" "2" "332" "37.8" "6.99" "7.62" "2" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "1861" "ENSG00000136827" "TOR1A" "B2RB58; hsa:1861; O14656; Q53Y64; Q96CA0" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "1.009" "1.142" "0.919" "0.950" "1.092" "0.962" "0.953" "1.057" "1.215" "158.7" "160.2" "181.2" "145.9" "150.7" "173.3" "152.6" "151.3" "167.7" "192.9" "" "" "" "" "" "" "" "" "" "" "142.7" "129.6" "163.9" "142.4" "124.4" "173.3" "114.3" "133.6" "150.1" "68.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5112619369075693620" "False" "High" "IsMasterProtein" "Q02338" "D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens OX=9606 GN=BDH1 PE=1 SV=3" "0.000" "False" "8.513" "8" "3" "3" "3" "343" "38.1" "8.95" "10.59" "3" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00106" "622" "ENSG00000161267; ENSG00000275544" "BDH1" "D3DXC0; hsa:622; Q02338; Q96ET1; Q9BRZ4" "" "Mitochondrial protein degradation; Utilization of Ketone Bodies; Synthesis of Ketone Bodies" "3" "0" "1.029" "1.155" "1.050" "1.042" "1.077" "0.948" "1.181" "1.081" "0.899" "204.9" "210.9" "236.6" "215.2" "213.6" "220.7" "194.2" "242.0" "221.5" "184.3" "" "" "" "" "" "" "" "" "" "" "184.3" "170.6" "214.0" "210.1" "176.3" "220.7" "145.4" "213.7" "198.2" "65.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2052900039050687679" "False" "High" "IsMasterProtein" "Q9Y6X3" "MAU2 chromatid cohesion factor homolog OS=Homo sapiens OX=9606 GN=MAU2 PE=1 SV=2" "0.000" "False" "8.506" "6" "3" "3" "3" "613" "69.0" "7.25" "5.58" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10345" "23383" "ENSG00000129933" "MAU2" "hsa:23383; Q66PT1; Q6P3S7; Q6ZTT2; Q9UFX8; Q9Y6X3" "Cohesin complex - Cornelia de Lange syndrome" "Cohesin Loading onto Chromatin" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2364171353668644168" "False" "High" "IsMasterProtein" "Q00653" "Nuclear factor NF-kappa-B p100 subunit OS=Homo sapiens OX=9606 GN=NFKB2 PE=1 SV=4" "0.000" "False" "8.496" "4" "3" "3" "2" "900" "96.7" "6.25" "9.56" "3" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00531, Pf00554, Pf16179" "4791" "ENSG00000077150" "NFKB2" "A8K9D9; D3DR83; hsa:4791; Q00653; Q04860; Q9BU75; Q9H471; Q9H472" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Neural crest differentiation; Thymic stromal lymphopoietin (TSLP) signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Toll-like receptor signaling related to MyD88; ApoE and miR-146 in inflammation and atherosclerosis; Ebola virus infection in host; Breast cancer pathway; Acute viral myocarditis; miRNA role in immune response in sepsis; Non-genomic actions of 1,25 dihydroxyvitamin D3; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; FGF23 signaling in hypophosphatemic rickets and related disorders; Mitochondrial immune response to SARS-CoV-2; Neuroinflammation and glutamatergic signaling; Network map of SARS-CoV-2 signaling pathway; Inclusion body myositis; GDNF signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKMTs methylate histone lysines; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; Interleukin-1 processing; SUMOylation of immune response proteins; DEx/H-box helicases activate type I IFN and inflammatory cytokines production" "43" "0" "0.841" "0.890" "0.737" "0.924" "0.932" "0.846" "0.837" "0.938" "1.634" "158.5" "133.3" "141.0" "116.9" "146.5" "147.7" "134.1" "132.7" "148.6" "259.0" "" "" "" "" "" "" "" "" "" "" "142.5" "107.8" "127.6" "114.1" "120.9" "147.7" "100.4" "117.2" "133.0" "92.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4334556934018890015" "False" "High" "IsMasterProtein" "P51808" "Dynein light chain Tctex-type 3 OS=Homo sapiens OX=9606 GN=DYNLT3 PE=1 SV=1" "0.000" "False" "8.483" "23" "2" "2" "2" "116" "13.1" "5.66" "8.95" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03645" "6990" "ENSG00000165169" "DYNLT3" "hsa:6990; P51808; Q6ICS3" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; 3q29 copy number variation syndrome; Orexin receptor pathway" "" "4" "0" "1.152" "1.174" "1.140" "1.159" "1.136" "1.100" "1.004" "1.271" "0.970" "160.0" "184.3" "187.9" "182.5" "185.5" "181.9" "176.0" "160.6" "203.4" "155.2" "" "" "" "" "" "" "" "" "" "" "143.9" "149.1" "170.0" "178.1" "153.1" "181.9" "131.8" "141.8" "182.0" "55.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286717889543307804" "False" "High" "IsMasterProtein" "O94889" "Kelch-like protein 18 OS=Homo sapiens OX=9606 GN=KLHL18 PE=1 SV=3" "0.000" "False" "8.483" "6" "3" "3" "3" "574" "63.6" "5.60" "9.61" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "" "" "Pf00651, Pf01344, Pf07707" "23276" "ENSG00000114648" "KLHL18" "A8K612; hsa:23276; O94889; Q7Z3E8; Q8N125" "" "" "0" "0" "1.039" "1.136" "0.990" "1.124" "1.057" "1.175" "1.141" "1.083" "1.205" "190.6" "198.0" "216.6" "188.7" "214.2" "201.5" "224.0" "217.5" "206.4" "229.8" "" "" "" "" "" "" "" "" "" "" "171.4" "160.2" "195.9" "184.2" "176.8" "201.5" "167.7" "192.1" "184.7" "82.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1191558879901855152" "False" "High" "IsMasterProtein" "O15213" "WD repeat-containing protein 46 OS=Homo sapiens OX=9606 GN=WDR46 PE=1 SV=3" "0.000" "False" "8.472" "5" "3" "4" "3" "610" "68.0" "9.67" "12.03" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf08149" "9277" "ENSG00000204221; ENSG00000206284; ENSG00000226916; ENSG00000227057; ENSG00000236222" "WDR46" "A6NDP5; hsa:9277; O15213; Q5HYZ0; Q5STK5; Q5STR3" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.992" "0.545" "1.075" "1.017" "0.614" "1.054" "1.036" "0.492" "0.360" "284.1" "281.8" "154.8" "305.4" "289.1" "174.5" "299.4" "294.5" "139.9" "102.4" "" "" "" "" "" "" "" "" "" "" "255.5" "228.0" "140.1" "298.1" "238.6" "174.5" "224.2" "260.1" "125.2" "36.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9120276004969488072" "False" "High" "IsMasterProtein" "Q15080" "Neutrophil cytosol factor 4 OS=Homo sapiens OX=9606 GN=NCF4 PE=1 SV=2" "0.000" "False" "8.470" "12" "4" "4" "4" "339" "39.0" "6.83" "9.47" "4" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00564, Pf00787" "4689" "ENSG00000100365" "NCF4" "A8K4F9; hsa:4689; O60808; Q15080; Q86U56; Q9BU98; Q9NP45" "Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "VEGFA-VEGFR2 Pathway; RAC1 GTPase cycle; RAC3 GTPase cycle; RAC2 GTPase cycle; Detoxification of Reactive Oxygen Species; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "11" "0" "1.258" "1.126" "1.032" "1.195" "1.050" "1.036" "0.939" "1.228" "5.202" "121.7" "153.1" "137.0" "125.7" "145.5" "127.8" "126.1" "114.4" "149.5" "633.3" "" "" "" "" "" "" "" "" "" "" "109.4" "123.9" "123.9" "122.7" "120.1" "127.8" "94.4" "101.0" "133.8" "226.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6923013739007896551" "False" "High" "IsMasterProtein" "P60033" "CD81 antigen OS=Homo sapiens OX=9606 GN=CD81 PE=1 SV=1" "0.000" "False" "8.456" "15" "2" "2" "2" "236" "25.8" "5.29" "11.30" "2" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00335" "975" "ENSG00000110651" "CD81" "hsa:975; P18582; P60033; Q5U0J6" "B cell receptor signaling pathway; Extracellular vesicles in the crosstalk of cardiac cells; IL-18 signaling pathway; 16p11.2 distal deletion syndrome" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Regulation of Complement cascade" "6" "0" "0.991" "0.885" "1.086" "0.893" "0.952" "0.936" "1.045" "0.957" "0.731" "203.7" "201.9" "180.3" "221.3" "181.9" "194.0" "190.8" "212.9" "195.0" "149.0" "" "" "" "" "" "" "" "" "" "" "183.2" "163.4" "163.1" "216.0" "150.1" "194.0" "142.9" "188.1" "174.5" "53.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7648847178929813829" "False" "High" "IsMasterProtein" "Q9H1K0" "Rabenosyn-5 OS=Homo sapiens OX=9606 GN=RBSN PE=1 SV=2" "0.000" "False" "8.452" "3" "2" "3" "2" "784" "88.8" "5.50" "9.97" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11464, Pf16601" "64145" "ENSG00000131381" "RBSN" "B4DWY8; C9J4P5; hsa:64145; Q3KP30; Q59EY8; Q8NAQ1; Q9H1K0" "" "Factors involved in megakaryocyte development and platelet production; Toll Like Receptor 9 (TLR9) Cascade" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6830968360322984650" "False" "High" "IsMasterProtein" "Q9BTV6" "Diphthine methyltransferase OS=Homo sapiens OX=9606 GN=DPH7 PE=1 SV=2" "0.000" "False" "8.451" "10" "4" "4" "4" "452" "50.5" "6.60" "6.00" "4" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf00400" "92715" "ENSG00000148399" "DPH7" "hsa:92715; Q96AB7; Q9BTV6" "" "Synthesis of diphthamide-EEF2" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "342990274906048664" "False" "High" "IsMasterProtein" "P48730" "Casein kinase I isoform delta OS=Homo sapiens OX=9606 GN=CSNK1D PE=1 SV=2" "0.000" "False" "8.445" "9" "4" "4" "1" "415" "47.3" "9.74" "11.28" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1453" "ENSG00000141551" "CSNK1D" "A2I2P2; hsa:1453; P48730; Q96KZ6; Q9BTN5" "Melatonin metabolism and effects; Wnt signaling pathway; Hedgehog signaling pathway" "Major pathway of rRNA processing in the nucleolus and cytosol; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Circadian Clock; COPII-mediated vesicle transport" "13" "0" "1.482" "1.136" "1.122" "1.283" "1.373" "1.300" "1.116" "1.278" "1.323" "164.0" "243.1" "186.4" "184.1" "210.5" "225.2" "213.3" "183.1" "209.7" "217.1" "" "" "" "" "" "" "" "" "" "" "147.5" "196.7" "168.6" "179.7" "173.7" "225.2" "159.7" "161.7" "187.6" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7174147483962909046" "False" "High" "IsMasterProtein" "Q9NRX1" "RNA-binding protein PNO1 OS=Homo sapiens OX=9606 GN=PNO1 PE=1 SV=1" "0.000" "False" "8.443" "13" "3" "3" "3" "252" "27.9" "9.73" "8.30" "3" "other biological processes" "cytosol;nucleus;other cell component" "" "" "56902" "ENSG00000115946" "PNO1" "A8K6Q0; hsa:56902; Q53G13; Q8WVB8; Q9NRX1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.948" "0.857" "1.007" "0.879" "0.787" "1.017" "1.040" "0.733" "1.844" "85.8" "81.3" "73.5" "86.4" "75.4" "67.5" "87.2" "89.2" "62.8" "158.2" "" "" "" "" "" "" "" "" "" "" "77.1" "65.8" "66.5" "84.3" "62.2" "67.5" "65.3" "78.7" "56.2" "56.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486901378795353796" "False" "High" "IsMasterProtein" "Q9H8H3" "Thiol S-methyltransferase TMT1A OS=Homo sapiens OX=9606 GN=TMT1A PE=1 SV=1" "0.000" "False" "8.421" "12" "2" "2" "2" "244" "28.3" "8.38" "9.68" "2" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf08241" "25840" "ENSG00000185432" "TMT1A" "hsa:25840; Q9H7R3; Q9H8H3; Q9UHZ7; Q9Y422" "" "Neutrophil degranulation" "1" "0" "0.954" "0.934" "0.982" "0.936" "0.853" "1.055" "1.025" "0.864" "1.124" "221.7" "211.5" "207.0" "217.6" "207.5" "189.1" "233.9" "227.1" "191.5" "249.1" "" "" "" "" "" "" "" "" "" "" "199.3" "171.2" "187.2" "212.4" "171.2" "189.1" "175.2" "200.6" "171.4" "88.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6391839617332390225" "False" "High" "IsMasterProtein" "P07203" "Glutathione peroxidase 1 OS=Homo sapiens OX=9606 GN=GPX1 PE=1 SV=4" "0.000" "False" "8.412" "15" "3" "4" "3" "203" "22.1" "6.55" "15.64" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf00255" "2876" "ENSG00000233276" "GPX1" "E9PAS1; hsa:2876; P07203; Q7Z5H1; Q9BW12" "Glutathione metabolism; Selenium micronutrient network; Folate metabolism; Amyotrophic lateral sclerosis (ALS); Trans-sulfuration, one-carbon metabolism and related pathways; Selenium metabolism and selenoproteins; Physico-chemical features and toxicity-associated pathways; VEGFA-VEGFR2 signaling; One-carbon metabolism and related pathways; TYROBP causal network in microglia; Oxidative stress response; Male infertility; p53 transcriptional gene network; Omega-6-fatty acids in senescence" "Detoxification of Reactive Oxygen Species; Synthesis of 15-eicosatetraenoic acid derivatives; Synthesis of 12-eicosatetraenoic acid derivatives; Synthesis of 5-eicosatetraenoic acids" "18" "0" "1.014" "1.102" "0.939" "1.102" "1.013" "0.993" "1.022" "1.020" "0.887" "355.1" "360.2" "391.3" "333.5" "391.3" "359.7" "352.5" "362.9" "362.1" "315.1" "" "" "" "" "" "" "" "" "" "" "319.2" "291.5" "354.0" "325.6" "322.9" "359.7" "263.9" "320.6" "324.0" "112.5" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1354238916064112101" "False" "High" "IsMasterProtein" "Q5T6V5" "Queuosine 5'-phosphate N-glycosylase/hydrolase OS=Homo sapiens OX=9606 GN=QNG1 PE=1 SV=1" "0.000" "False" "8.411" "7" "3" "3" "3" "341" "39.0" "5.88" "8.06" "3" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf10343" "84267" "ENSG00000165118" "QNG1" "B2RPI6; hsa:84267; Q5T6V5; Q8N2B1; Q9BT18" "" "" "0" "0" "0.990" "0.922" "1.001" "0.990" "0.907" "1.258" "0.896" "0.878" "1.842" "157.2" "155.6" "145.0" "157.4" "155.6" "142.6" "197.8" "140.8" "138.0" "289.6" "" "" "" "" "" "" "" "" "" "" "141.3" "125.9" "131.2" "153.7" "128.4" "142.6" "148.1" "124.4" "123.5" "103.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4190434278171363026" "False" "High" "IsMasterProtein" "Q92547" "DNA topoisomerase 2-binding protein 1 OS=Homo sapiens OX=9606 GN=TOPBP1 PE=1 SV=3" "0.000" "False" "8.410" "3" "3" "3" "3" "1522" "170.6" "6.96" "8.06" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00533" "11073" "ENSG00000163781" "TOPBP1" "B7Z7W8; hsa:11073; Q7LGC1; Q92547; Q9UEB9" "ATR signaling" "Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "837370257864581378" "False" "High" "IsMasterProtein" "Q01415" "N-acetylgalactosamine kinase OS=Homo sapiens OX=9606 GN=GALK2 PE=1 SV=1" "0.000" "False" "8.408" "7" "3" "3" "3" "458" "50.3" "6.61" "10.37" "3" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00288, Pf08544, Pf10509" "2585" "ENSG00000156958" "GALK2" "hsa:2585; Q01415; Q7Z4Q4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4219913778501772025" "False" "High" "IsMasterProtein" "Q96PE7" "Methylmalonyl-CoA epimerase, mitochondrial OS=Homo sapiens OX=9606 GN=MCEE PE=1 SV=1" "0.000" "False" "8.403" "17" "3" "3" "3" "176" "18.7" "9.09" "11.32" "3" "other metabolic processes" "mitochondrion" "other molecular function" "Pf13669" "84693" "ENSG00000124370" "MCEE" "hsa:84693; Q53TP1; Q8WW63; Q96PE7" "Vitamin B12 metabolism" "Propionyl-CoA catabolism" "2" "0" "0.938" "1.015" "1.011" "1.029" "1.027" "1.027" "1.005" "1.074" "0.759" "513.3" "481.3" "521.2" "518.8" "528.1" "527.2" "527.0" "515.8" "551.2" "389.7" "" "" "" "" "" "" "" "" "" "" "461.5" "389.5" "471.5" "506.4" "435.8" "527.2" "394.6" "455.5" "493.2" "139.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7450881141775825578" "False" "High" "IsMasterProtein" "Q9H8W3" "Protein FAM204A OS=Homo sapiens OX=9606 GN=FAM204A PE=1 SV=1" "0.000" "False" "8.400" "11" "3" "3" "3" "233" "27.0" "7.91" "10.18" "3" "" "" "" "" "63877" "ENSG00000165669" "FAM204A" "D3DRC6; hsa:63877; Q5T373; Q9H5V5; Q9H8W3" "" "" "0" "0" "0.962" "0.985" "0.996" "1.104" "1.007" "1.032" "1.010" "0.924" "0.884" "336.0" "323.1" "330.8" "334.7" "371.0" "338.5" "346.9" "339.3" "310.4" "296.8" "" "" "" "" "" "" "" "" "" "" "302.1" "261.5" "299.2" "326.7" "306.2" "338.5" "259.7" "299.7" "277.8" "106.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343350754074728938" "False" "High" "IsMasterProtein" "P83881" "Large ribosomal subunit protein eL42 OS=Homo sapiens OX=9606 GN=RPL36A PE=1 SV=2" "0.000" "False" "8.387" "24" "3" "3" "3" "106" "12.4" "10.58" "8.74" "3" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;translational apparatus" "other molecular function" "Pf00935" "6173" "ENSG00000241343" "RPL36A" "hsa:6173; P09896; P10661; P83881; Q08ES5; Q5J9I6" "Cytoplasmic ribosomal proteins" "GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.975" "0.983" "0.901" "1.044" "0.974" "1.044" "1.038" "0.962" "0.911" "529.8" "516.6" "520.6" "477.3" "553.3" "515.8" "553.1" "549.9" "509.5" "482.5" "" "" "" "" "" "" "" "" "" "" "476.3" "418.0" "470.9" "465.9" "456.6" "515.8" "414.1" "485.7" "455.9" "172.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853827814974880096" "False" "High" "IsMasterProtein" "P52747" "Zinc finger protein 143 OS=Homo sapiens OX=9606 GN=ZNF143 PE=1 SV=2" "0.000" "False" "8.386" "6" "3" "3" "3" "638" "68.9" "6.05" "7.11" "3" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "7702" "ENSG00000166478" "ZNF143" "A8K518; B4DLY5; E7ER34; hsa:7702; O75559; P52747; Q8WUK9" "IL-18 signaling pathway" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "4" "0" "0.927" "0.913" "1.032" "0.966" "1.225" "0.885" "0.971" "0.891" "1.273" "170.7" "158.2" "155.7" "176.2" "164.9" "209.0" "151.0" "165.7" "152.1" "217.2" "" "" "" "" "" "" "" "" "" "" "153.4" "128.0" "140.9" "172.0" "136.1" "209.0" "113.0" "146.3" "136.1" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5516289566189376071" "False" "High" "IsMasterProtein" "Q13084" "Large ribosomal subunit protein bL28m OS=Homo sapiens OX=9606 GN=MRPL28 PE=1 SV=4" "0.000" "False" "8.382" "10" "3" "3" "3" "256" "30.1" "8.29" "9.03" "3" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00830" "10573" "ENSG00000086504" "MRPL28" "B2RCM4; D3DU46; hsa:10573; Q13084; Q4TT39; Q96S26; Q9BQD8; Q9BR04" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.972" "0.971" "1.113" "0.919" "0.941" "0.907" "0.928" "1.123" "1.203" "122.6" "119.2" "119.0" "136.4" "112.6" "115.4" "111.2" "113.8" "137.7" "147.5" "" "" "" "" "" "" "" "" "" "" "110.2" "96.4" "107.7" "133.2" "92.9" "115.4" "83.3" "100.5" "123.2" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2662699924812854810" "False" "High" "IsMasterProtein" "Q9P219" "Protein Daple OS=Homo sapiens OX=9606 GN=CCDC88C PE=1 SV=3" "0.000" "False" "8.381" "3" "4" "6" "4" "2028" "228.1" "6.23" "14.26" "4" "cell-cell signaling;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf19047" "440193" "ENSG00000015133" "CCDC88C" "hsa:440193; Q69YK1; Q7L1M2; Q86SX7; Q8IYG8; Q9P219" "Ectoderm differentiation; Ectoderm differentiation" "Negative regulation of TCF-dependent signaling by DVL-interacting proteins" "3" "0" "1.038" "0.962" "0.979" "1.037" "1.015" "1.121" "0.996" "1.117" "2.504" "59.0" "61.2" "56.8" "57.7" "61.2" "59.9" "66.1" "58.7" "65.8" "147.7" "" "" "" "" "" "" "" "" "" "" "53.0" "49.5" "51.3" "56.4" "50.5" "59.9" "49.5" "51.9" "58.9" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1054050603788689952" "False" "High" "IsMasterProtein" "Q86YV0" "RAS protein activator like-3 OS=Homo sapiens OX=9606 GN=RASAL3 PE=1 SV=2" "0.000" "False" "8.376" "3" "2" "2" "2" "1011" "111.8" "8.75" "10.09" "2" "other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00616" "64926" "ENSG00000105122" "RASAL3" "hsa:64926; Q86YV0; Q8N2T9; Q9H735" "Ras signaling" "Regulation of RAS by GAPs" "2" "0" "0.952" "0.969" "1.205" "0.895" "1.096" "0.906" "1.114" "1.006" "1.352" "35.3" "33.6" "34.2" "42.6" "31.6" "38.7" "32.0" "39.4" "35.5" "47.7" "" "" "" "" "" "" "" "" "" "" "31.8" "27.2" "31.0" "41.5" "26.1" "38.7" "24.0" "34.8" "31.8" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "796383816243011669" "False" "High" "IsMasterProtein" "O43513" "Mediator of RNA polymerase II transcription subunit 7 OS=Homo sapiens OX=9606 GN=MED7 PE=1 SV=1" "0.000" "False" "8.368" "15" "2" "2" "2" "233" "27.2" "5.78" "7.57" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05983" "9443" "ENSG00000155868" "MED7" "hsa:9443; O43513" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8551747306859767135" "False" "High" "IsMasterProtein" "Q86XZ4" "Spermatogenesis-associated serine-rich protein 2 OS=Homo sapiens OX=9606 GN=SPATS2 PE=1 SV=1" "0.000" "False" "8.362" "6" "2" "2" "2" "545" "59.5" "8.90" "9.03" "2" "" "cytosol;other cell component" "" "Pf07139" "65244" "ENSG00000123352" "SPATS2" "A8K8G9; hsa:65244; Q86XZ4; Q9H7D4; Q9H8Y7; Q9H8Z8" "" "" "0" "0" "1.064" "1.028" "0.986" "0.885" "1.060" "1.008" "0.860" "0.978" "1.300" "118.4" "126.0" "121.7" "116.8" "104.7" "125.5" "119.4" "101.9" "115.8" "153.9" "" "" "" "" "" "" "" "" "" "" "106.5" "101.9" "110.1" "114.0" "86.4" "125.5" "89.4" "90.0" "103.6" "54.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1066675422461662542" "False" "High" "IsMasterProtein" "Q8WVE0" "EEF1A lysine methyltransferase 1 OS=Homo sapiens OX=9606 GN=EEF1AKMT1 PE=1 SV=1" "0.000" "False" "8.358" "14" "3" "3" "3" "214" "24.5" "4.55" "8.58" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf10237" "221143" "ENSG00000150456" "EEF1AKMT1" "B5G4V1; hsa:221143; Q8WVE0" "" "Protein methylation" "1" "0" "0.911" "0.911" "0.809" "0.870" "0.819" "0.919" "0.858" "0.904" "1.141" "397.3" "362.0" "362.1" "321.4" "345.6" "325.3" "365.0" "341.1" "359.1" "453.5" "" "" "" "" "" "" "" "" "" "" "357.2" "292.9" "327.6" "313.8" "285.2" "325.3" "273.3" "301.3" "321.3" "161.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2435225049251902172" "False" "High" "IsMasterProtein" "Q8NEY8" "Periphilin-1 OS=Homo sapiens OX=9606 GN=PPHLN1 PE=1 SV=2" "0.000" "False" "8.339" "6" "3" "3" "3" "458" "52.7" "9.11" "10.01" "3" "cell organization and biogenesis;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "" "Pf11488" "51535" "ENSG00000134283" "PPHLN1" "E9PAX8; hsa:51535; Q86YT2; Q8IXN3; Q8NEY8; Q8TB09; Q96NB9; Q9NXL4; Q9P0P6; Q9P0R9" "" "" "0" "0" "0.989" "1.055" "1.054" "1.006" "1.053" "1.107" "0.966" "0.999" "1.247" "412.0" "407.3" "434.5" "434.4" "414.2" "433.7" "455.9" "397.9" "411.5" "513.9" "" "" "" "" "" "" "" "" "" "" "370.4" "329.6" "393.0" "424.0" "341.8" "433.7" "341.3" "351.4" "368.2" "183.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1307074189875800146" "False" "High" "IsMasterProtein" "O14732" "Inositol monophosphatase 2 OS=Homo sapiens OX=9606 GN=IMPA2 PE=1 SV=1" "0.000" "False" "8.311" "8" "3" "3" "3" "288" "31.3" "6.61" "9.47" "3" "other metabolic processes;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00459" "3613" "ENSG00000141401" "IMPA2" "B0YJ29; hsa:3613; O14732; Q9UJT3" "" "Synthesis of IP2, IP, and Ins in the cytosol" "1" "0" "1.014" "1.117" "0.934" "1.017" "0.997" "1.011" "0.962" "1.099" "0.846" "258.2" "261.8" "288.6" "241.1" "262.6" "257.4" "261.0" "248.5" "283.7" "218.6" "" "" "" "" "" "" "" "" "" "" "232.2" "211.8" "261.0" "235.4" "216.7" "257.4" "195.4" "219.5" "253.9" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8193336255424769444" "False" "High" "IsMasterProtein" "Q92845" "Kinesin-associated protein 3 OS=Homo sapiens OX=9606 GN=KIFAP3 PE=1 SV=2" "0.000" "False" "8.306" "4" "3" "3" "2" "792" "91.1" "5.08" "9.71" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf05804" "22920" "ENSG00000075945" "KIFAP3" "B1AKU4; B1AKU5; B2RDL1; B7Z8A3; F5H591; hsa:22920; Q8NHU7; Q92845; Q9H416" "Genes related to primary cilium development (based on CRISPR)" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; MHC class II antigen presentation; Intraflagellar transport; COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "6" "0" "1.029" "1.144" "0.628" "0.938" "0.948" "1.000" "0.988" "1.063" "1.492" "56.9" "58.5" "65.0" "35.7" "53.4" "53.9" "56.9" "56.1" "60.5" "84.8" "" "" "" "" "" "" "" "" "" "" "51.1" "47.3" "58.8" "34.8" "44.0" "53.9" "42.6" "49.6" "54.1" "30.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6653368877228174187" "False" "High" "IsMasterProtein" "Q9NRX2" "Large ribosomal subunit protein bL17m OS=Homo sapiens OX=9606 GN=MRPL17 PE=1 SV=1" "0.000" "False" "8.305" "21" "4" "4" "4" "175" "20.0" "10.11" "11.61" "4" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01196" "63875" "ENSG00000158042" "MRPL17" "D3DQU3; hsa:63875; Q6IAH8; Q96Q53; Q9C066; Q9NRX2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.050" "1.052" "1.048" "1.038" "0.968" "1.150" "1.089" "0.994" "1.163" "369.3" "387.6" "388.3" "387.2" "383.3" "357.5" "424.7" "402.0" "367.1" "429.5" "" "" "" "" "" "" "" "" "" "" "332.0" "313.6" "351.3" "377.9" "316.3" "357.5" "318.0" "355.1" "328.5" "153.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2150504765694079773" "False" "High" "IsMasterProtein" "Q4ADV7" "Guanine nucleotide exchange factor subunit RIC1 OS=Homo sapiens OX=9606 GN=RIC1 PE=1 SV=2" "0.000" "False" "8.297" "2" "3" "3" "3" "1423" "159.2" "6.38" "9.73" "3" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf07064" "57589" "ENSG00000107036" "RIC1" "B2RN24; B7ZM67; G5E932; hsa:57589; Q4ADV7; Q4VXJ8; Q4VXJ9; Q76MT5; Q8N6E0; Q8TEH4; Q9H0A5; Q9H9S1" "" "RAB GEFs exchange GTP for GDP on RABs; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.884" "1.253" "1.086" "1.195" "1.253" "1.217" "1.087" "1.031" "1.035" "40.4" "35.7" "50.7" "43.9" "48.3" "50.7" "49.2" "43.9" "41.7" "41.8" "" "" "" "" "" "" "" "" "" "" "36.3" "28.9" "45.8" "42.9" "39.8" "50.7" "36.8" "38.8" "37.3" "14.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4773466302739239443" "False" "High" "IsMasterProtein" "Q8IYA6" "Cytoskeleton-associated protein 2-like OS=Homo sapiens OX=9606 GN=CKAP2L PE=1 SV=4" "0.000" "False" "8.296" "4" "3" "3" "3" "745" "83.5" "9.83" "7.00" "3" "" "cytosol;cytoskeleton" "" "Pf15297" "150468" "ENSG00000169607" "CKAP2L" "A8K915; B4DZE3; B7ZAC6; F5H0M5; hsa:150468; Q53QF8; Q53RS8; Q8IYA6; Q8N1J8" "2q13 copy number variation syndrome" "" "1" "0" "1.257" "1.384" "1.052" "1.213" "1.399" "1.346" "1.240" "1.227" "1.220" "154.1" "193.8" "213.2" "162.1" "187.0" "215.6" "207.4" "191.1" "189.1" "188.1" "" "" "" "" "" "" "" "" "" "" "138.6" "156.8" "192.9" "158.3" "154.3" "215.6" "155.3" "168.8" "169.2" "67.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1896237481092242514" "False" "High" "IsMasterProtein" "Q8NFZ0" "F-box DNA helicase 1 OS=Homo sapiens OX=9606 GN=FBH1 PE=1 SV=2" "0.000" "False" "8.291" "3" "3" "3" "3" "1043" "117.6" "8.25" "5.52" "3" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00580, Pf12937, Pf13361" "84893" "ENSG00000134452" "FBH1" "hsa:84893; Q5JVB0; Q5JVB1; Q7Z4Q6; Q7Z4R0; Q8N1P5; Q8N586; Q8NFZ0; Q96E82; Q96K67; Q96SW7; Q9UFB2" "" "" "0" "0" "1.153" "0.926" "0.868" "1.094" "0.835" "0.985" "1.102" "0.902" "0.814" "58.0" "66.9" "53.8" "50.4" "63.5" "48.5" "57.1" "64.0" "52.4" "47.3" "" "" "" "" "" "" "" "" "" "" "52.2" "54.1" "48.6" "49.2" "52.4" "48.5" "42.8" "56.5" "46.9" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4068487784358334043" "False" "High" "IsMasterProtein" "Q8TDX7" "Serine/threonine-protein kinase Nek7 OS=Homo sapiens OX=9606 GN=NEK7 PE=1 SV=1" "0.000" "False" "8.288" "7" "2" "2" "2" "302" "34.5" "8.25" "8.69" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "140609" "ENSG00000151414" "NEK7" "A6NGT8; hsa:140609; Q8TDX7" "Ciliary landscape; EPAC1 and PKA reduction of retinal inflammation" "Nuclear Pore Complex (NPC) Disassembly; EML4 and NUDC in mitotic spindle formation; Activation of NIMA Kinases NEK9, NEK6, NEK7" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2194368294587715280" "False" "High" "IsMasterProtein" "Q16513" "Serine/threonine-protein kinase N2 OS=Homo sapiens OX=9606 GN=PKN2 PE=1 SV=1" "0.000" "False" "8.271" "4" "3" "3" "2" "984" "112.0" "6.30" "5.80" "3" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433, Pf02185" "5586" "ENSG00000065243" "PKN2" "B4DQ21; B4DTP5; B4DVG1; D3DT24; hsa:5586; Q08AF4; Q16513; Q9H1W4" "PI3K-Akt signaling pathway" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOB GTPase cycle; RHO GTPases activate PKNs" "6" "0" "0.898" "0.904" "0.903" "0.970" "0.880" "0.894" "0.845" "0.842" "1.074" "190.8" "171.4" "172.5" "172.3" "185.0" "167.8" "170.6" "161.3" "160.7" "205.0" "" "" "" "" "" "" "" "" "" "" "171.6" "138.7" "156.0" "168.2" "152.7" "167.8" "127.7" "142.4" "143.8" "73.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2063418146080875135" "False" "High" "IsMasterProtein" "O76094" "Signal recognition particle subunit SRP72 OS=Homo sapiens OX=9606 GN=SRP72 PE=1 SV=3" "0.000" "False" "8.260" "3" "2" "3" "2" "671" "74.6" "9.26" "8.85" "2" "other biological processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08492, Pf13181, Pf17004" "6731" "ENSG00000174780" "SRP72" "G5E9Z8; hsa:6731; O76094; Q7Z3C0" "" "SRP-dependent cotranslational protein targeting to membrane" "1" "0" "1.232" "0.880" "0.876" "1.214" "1.214" "1.420" "1.170" "1.283" "1.099" "430.0" "529.8" "378.3" "376.5" "521.9" "521.9" "610.7" "502.9" "551.5" "472.6" "" "" "" "" "" "" "" "" "" "" "386.6" "428.7" "342.2" "367.5" "430.7" "521.9" "457.3" "444.2" "493.5" "168.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4119933875415276465" "False" "High" "IsMasterProtein" "P07902" "Galactose-1-phosphate uridylyltransferase OS=Homo sapiens OX=9606 GN=GALT PE=1 SV=3" "0.000" "False" "8.254" "7" "2" "2" "2" "379" "43.3" "6.99" "7.71" "2" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf01087, Pf02744" "2592" "ENSG00000213930" "GALT" "B4E097; E7ET32; hsa:2592; P07902; Q14355; Q14356; Q14357; Q14358; Q14359; Q14360; Q14361; Q14363; Q14364; Q14365; Q14369; Q14370; Q14371; Q14372; Q14373; Q14374; Q14375; Q14377; Q14378; Q14380; Q14381; Q14382; Q14383; Q14384; Q14385; Q14386; Q14387; Q14389; Q16766; Q53XK1; Q5VZ81; Q96BY1" "Disorders of galactose metabolism ; Primary ovarian insufficiency" "Defective GALT can cause GALCT; Galactose catabolism" "4" "0" "1.052" "0.942" "0.976" "1.074" "1.025" "1.117" "1.057" "0.960" "1.113" "68.9" "72.4" "64.8" "67.2" "74.0" "70.6" "76.9" "72.8" "66.1" "76.6" "" "" "" "" "" "" "" "" "" "" "61.9" "58.6" "58.7" "65.6" "61.0" "70.6" "57.6" "64.3" "59.1" "27.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2236984144033134213" "False" "High" "IsMasterProtein" "Q9NV70" "Exocyst complex component 1 OS=Homo sapiens OX=9606 GN=EXOC1 PE=1 SV=4" "0.000" "False" "8.253" "3" "3" "3" "3" "894" "101.9" "6.61" "9.47" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf09763, Pf15277, Pf20654" "55763" "ENSG00000090989" "EXOC1" "hsa:55763; Q504V4; Q8WUE7; Q96T15; Q9NV70; Q9NZE4" "Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "4" "0" "0.948" "0.964" "0.928" "0.960" "0.938" "1.106" "0.935" "0.966" "2.862" "286.6" "271.7" "276.4" "266.1" "275.1" "268.9" "317.1" "267.9" "276.8" "820.1" "" "" "" "" "" "" "" "" "" "" "257.7" "219.9" "250.0" "259.7" "227.0" "268.9" "237.5" "236.6" "247.7" "292.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6993572615210098163" "False" "High" "IsMasterProtein" "Q9UJV9" "Probable ATP-dependent RNA helicase DDX41 OS=Homo sapiens OX=9606 GN=DDX41 PE=1 SV=2" "0.000" "False" "8.251" "2" "1" "2" "1" "622" "69.8" "6.84" "6.90" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00270, Pf00271" "51428" "ENSG00000183258" "DDX41" "B2RDC8; Q96BK6; Q96K05; Q9NT96; Q9NW04; Q9UJV9" "5q35 copy number variation" "mRNA Splicing - Major Pathway; Regulation of innate immune responses to cytosolic DNA; IRF3-mediated induction of type I IFN" "5" "0" "1.108" "0.850" "0.711" "0.861" "0.961" "0.758" "0.650" "0.677" "1.182" "26.7" "29.5" "22.7" "19.0" "23.0" "25.6" "20.2" "17.3" "18.1" "31.5" "" "" "" "" "" "" "" "" "" "" "24.0" "23.9" "20.5" "18.5" "18.9" "25.6" "15.1" "15.3" "16.2" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7824788000835968644" "False" "High" "IsMasterProtein" "O15182" "Centrin-3 OS=Homo sapiens OX=9606 GN=CETN3 PE=1 SV=2" "0.000" "False" "8.251" "16" "3" "4" "2" "167" "19.5" "4.74" "10.50" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13499" "1070" "ENSG00000153140" "CETN3" "hsa:1070; O15182; Q53YD2; Q9BS23" "Breast cancer pathway" "" "1" "0" "1.034" "1.013" "0.849" "1.291" "0.840" "1.082" "1.187" "1.107" "1.287" "52.8" "54.6" "53.5" "44.9" "68.2" "44.4" "57.1" "62.7" "58.5" "68.0" "" "" "" "" "" "" "" "" "" "" "47.5" "44.2" "48.4" "43.8" "56.3" "44.4" "42.8" "55.4" "52.3" "24.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538396539459298741" "False" "High" "IsMasterProtein" "Q9H6Q4" "Cytosolic iron-sulfur assembly component 3 OS=Homo sapiens OX=9606 GN=CIAO3 PE=1 SV=1" "0.000" "False" "8.245" "7" "3" "3" "3" "476" "53.0" "7.23" "10.64" "3" "cell organization and biogenesis;stress response;other biological processes" "other cell component" "other molecular function" "Pf02256, Pf02906" "64428" "ENSG00000103245" "CIAO3" "A1L385; B3KTJ3; hsa:64428; Q53GC6; Q96S10; Q9H6J8; Q9H6Q4" "" "Cytosolic iron-sulfur cluster assembly" "1" "0" "0.998" "0.984" "0.930" "0.995" "1.026" "1.005" "1.028" "0.963" "0.853" "408.4" "407.6" "401.8" "379.7" "406.5" "419.1" "410.5" "419.8" "393.1" "348.2" "" "" "" "" "" "" "" "" "" "" "367.2" "329.8" "363.4" "370.6" "335.5" "419.1" "307.4" "370.8" "351.8" "124.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1917909410339364485" "False" "High" "IsMasterProtein" "Q96QC0" "Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Homo sapiens OX=9606 GN=PPP1R10 PE=1 SV=1" "0.000" "False" "8.240" "4" "4" "4" "4" "940" "99.0" "9.17" "13.64" "4" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00642, Pf08711" "5514" "ENSG00000204569; ENSG00000206489; ENSG00000227804; ENSG00000230995; ENSG00000231737; ENSG00000235291; ENSG00000238104" "PPP1R10" "hsa:5514; O00405; Q96QC0" "" "" "0" "0" "1.066" "0.988" "0.978" "1.085" "1.079" "1.050" "0.975" "0.888" "1.484" "493.6" "526.1" "487.5" "482.8" "535.8" "532.5" "518.2" "481.3" "438.4" "732.4" "" "" "" "" "" "" "" "" "" "" "443.8" "425.7" "441.0" "471.3" "442.2" "532.5" "388.0" "425.1" "392.3" "261.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6765720071674471585" "False" "High" "IsMasterProtein" "Q15633" "RISC-loading complex subunit TARBP2 OS=Homo sapiens OX=9606 GN=TARBP2 PE=1 SV=3" "0.000" "False" "8.231" "8" "3" "3" "3" "366" "39.0" "6.54" "10.56" "3" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "6895" "ENSG00000139546" "TARBP2" "hsa:6895; Q12878; Q15633; Q8WY32; Q8WY33; Q9BRY2" "Fragile X syndrome; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "6" "0" "1.018" "1.038" "1.566" "0.793" "1.330" "0.953" "1.081" "1.237" "1.127" "173.9" "177.2" "180.6" "272.5" "138.0" "231.3" "165.7" "188.0" "215.2" "196.0" "" "" "" "" "" "" "" "" "" "" "156.4" "143.3" "163.4" "266.0" "113.9" "231.3" "124.1" "166.1" "192.6" "70.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4848605729142375391" "False" "High" "IsMasterProtein" "P00813" "Adenosine deaminase OS=Homo sapiens OX=9606 GN=ADA PE=1 SV=3" "0.000" "False" "8.214" "6" "2" "2" "2" "363" "40.7" "5.95" "8.39" "2" "cell adhesion;cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00962" "100" "ENSG00000196839" "ADA" "hsa:100; P00813; Q53F92; Q6LA59" "" "Ribavirin ADME; Purine salvage; Defective ADA disrupts (deoxy)adenosine deamination" "3" "0" "0.982" "0.855" "0.957" "0.963" "0.690" "1.061" "0.852" "0.974" "0.941" "55.7" "54.7" "47.6" "53.3" "53.6" "38.4" "59.1" "47.5" "54.2" "52.4" "" "" "" "" "" "" "" "" "" "" "50.1" "44.2" "43.1" "52.0" "44.2" "38.4" "44.3" "41.9" "48.5" "18.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6395227692188504005" "False" "High" "IsMasterProtein" "Q7Z3K3" "Pogo transposable element with ZNF domain OS=Homo sapiens OX=9606 GN=POGZ PE=1 SV=2" "0.000" "False" "8.205" "3" "3" "3" "3" "1410" "155.2" "7.40" "9.69" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03184, Pf03221" "23126" "ENSG00000143442" "POGZ" "B4DTP8; B4DYL9; B7ZBY5; E9PM80; hsa:23126; O75049; Q3LIC4; Q5SZS1; Q5SZS2; Q5SZS3; Q5SZS4; Q7Z3K3; Q8TDZ7; Q9Y4X7" "" "" "0" "0" "0.942" "0.944" "0.938" "0.996" "1.009" "1.146" "0.898" "0.935" "1.538" "131.2" "123.6" "123.9" "123.0" "130.7" "132.3" "150.4" "117.8" "122.7" "201.8" "" "" "" "" "" "" "" "" "" "" "117.9" "100.0" "112.0" "120.1" "107.9" "132.3" "112.6" "104.0" "109.8" "72.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3323196945052743606" "False" "High" "IsMasterProtein" "Q9UGC7" "Peptide chain release factor 1-like, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1L PE=1 SV=1" "0.000" "False" "8.205" "9" "3" "3" "3" "380" "43.6" "8.34" "11.04" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "54516" "ENSG00000112031" "MTRF1L" "B3KTA0; hsa:54516; Q3KR06; Q5TF44; Q5TF50; Q96CC5; Q96EX4; Q96K40; Q9UGC7" "" "Mitochondrial translation termination" "1" "0" "0.951" "0.936" "1.028" "1.007" "0.989" "0.907" "0.995" "0.993" "0.852" "141.9" "135.0" "132.8" "145.8" "142.8" "140.3" "128.7" "141.1" "140.9" "120.9" "" "" "" "" "" "" "" "" "" "" "127.6" "109.2" "120.1" "142.4" "117.9" "140.3" "96.4" "124.7" "126.0" "43.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8872418037025781977" "False" "High" "IsMasterProtein" "Q5VTB9" "E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens OX=9606 GN=RNF220 PE=1 SV=1" "0.000" "False" "8.198" "4" "2" "2" "2" "566" "62.7" "6.04" "8.81" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13923, Pf15926" "55182" "ENSG00000187147" "RNF220" "B3KPJ3; B4DLZ9; E9PCS1; hsa:55182; Q4KMX2; Q5VTB9; Q9NVP6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.977" "1.046" "0.887" "1.074" "1.045" "1.025" "1.015" "1.021" "1.088" "295.1" "288.2" "308.8" "261.7" "316.9" "308.3" "302.6" "299.7" "301.2" "321.0" "" "" "" "" "" "" "" "" "" "" "265.3" "233.2" "279.3" "255.4" "261.5" "308.3" "226.6" "264.7" "269.5" "114.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6075912895449175249" "False" "High" "IsMasterProtein" "Q9NTG7" "NAD-dependent protein deacetylase sirtuin-3, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT3 PE=1 SV=2" "0.000" "False" "8.197" "6" "2" "2" "2" "399" "43.5" "8.70" "8.89" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02146" "23410" "ENSG00000142082" "SIRT3" "B7Z5U6; hsa:23410; Q9NTG7; Q9Y6E8" "Energy metabolism; NAD metabolism, sirtuins and aging; NAD+ metabolism; NAD+ biosynthetic pathways; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence" "FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes; Transcriptional activation of mitochondrial biogenesis; Regulation of FOXO transcriptional activity by acetylation" "8" "0" "0.973" "0.881" "0.812" "0.993" "0.971" "0.905" "1.056" "1.012" "0.861" "84.5" "82.2" "74.4" "68.6" "83.9" "82.0" "76.4" "89.2" "85.4" "72.7" "" "" "" "" "" "" "" "" "" "" "75.9" "66.5" "67.3" "66.9" "69.2" "82.0" "57.2" "78.8" "76.4" "26.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1892003299666365822" "False" "High" "IsMasterProtein" "P60484" "Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1" "0.000" "False" "8.183" "7" "4" "5" "4" "403" "47.1" "6.37" "10.17" "4" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00102, Pf10409" "5728" "ENSG00000171862; ENSG00000284792" "PTEN" "B2R904; F2YHV0; O00633; O02679; P60484; Q6ICT7" "Androgen receptor signaling pathway; Leptin signaling pathway; Microtubule cytoskeleton regulation; Glioblastoma signaling pathways; Androgen receptor network in prostate cancer; T cell receptor and co-stimulatory signaling; Focal adhesion; Hepatocyte growth factor receptor signaling; Copper homeostasis; MECP2 and associated Rett syndrome; Pathways affected in adenoid cystic carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miRNA regulation of p53 pathway in prostate cancer; Clear cell renal cell carcinoma pathways; Endometrial cancer; PI3K-Akt signaling pathway; Somatroph axis (GH) and its relationship to dietary restriction and aging; Breast cancer pathway; Extracellular vesicles in the crosstalk of cardiac cells; EGF/EGFR signaling pathway; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; Small cell lung cancer; Head and neck squamous cell carcinoma; Melanoma; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; mBDNF and proBDNF regulation of GABA neurotransmission; 16p11.2 proximal deletion syndrome; p53 transcriptional gene network; Pleural mesothelioma; CCL18 signaling pathway; GDNF signaling; Urotensin-II-mediated signaling pathway; TROP2 regulatory signaling; Primary ovarian insufficiency; Macrophage-stimulating protein (MSP) signaling network map; DNA damage response (only ATM dependent)" "Downstream TCR signaling; TP53 Regulates Metabolic Genes; Regulation of PTEN stability and activity; Ub-specific processing proteases; Transcriptional Regulation by MECP2; Synthesis of PIPs at the plasma membrane; Synthesis of IP3 and IP4 in the cytosol; Ovarian tumor domain proteases; Negative regulation of the PI3K/AKT network; Regulation of PTEN localization; PTEN Loss of Function in Cancer; Regulation of PTEN mRNA translation" "55" "0" "1.039" "1.031" "0.990" "1.159" "0.844" "1.276" "1.174" "1.021" "1.393" "39.9" "41.5" "41.2" "39.6" "46.3" "33.7" "51.0" "46.9" "40.8" "55.6" "" "" "" "" "" "" "" "" "" "" "35.9" "33.6" "37.3" "38.6" "38.2" "33.7" "38.2" "41.4" "36.5" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6865133109964514058" "False" "High" "IsMasterProtein" "Q9NVS2" "Large ribosomal subunit protein mL66 OS=Homo sapiens OX=9606 GN=MRPS18A PE=1 SV=1" "0.000" "False" "8.178" "17" "3" "3" "3" "196" "22.2" "10.33" "9.08" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01084" "55168" "ENSG00000096080" "MRPS18A" "A6XND3; hsa:55168; Q5QPA4; Q9NVS2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.853" "0.950" "0.853" "0.937" "0.938" "0.910" "0.915" "0.756" "0.968" "57.7" "49.2" "54.8" "49.2" "54.0" "54.1" "52.5" "52.8" "43.6" "55.8" "" "" "" "" "" "" "" "" "" "" "51.9" "39.8" "49.5" "48.0" "44.6" "54.1" "39.3" "46.6" "39.0" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4105877346039324927" "False" "High" "IsMasterProtein" "Q9BV29" "Coiled-coil domain-containing protein 32 OS=Homo sapiens OX=9606 GN=CCDC32 PE=1 SV=2" "0.000" "False" "8.169" "16" "2" "3" "2" "185" "20.6" "4.53" "12.99" "2" "cell organization and biogenesis;other biological processes" "other membranes" "" "Pf14989" "90416" "ENSG00000128891" "CCDC32" "A8KAL4; Q86TC4; Q8N788; Q8NAR7; Q9BV29" "" "" "0" "0" "1.001" "1.151" "0.923" "1.033" "1.168" "0.942" "1.040" "1.156" "1.033" "454.2" "454.4" "522.8" "419.4" "469.0" "530.6" "427.8" "472.6" "525.2" "469.1" "" "" "" "" "" "" "" "" "" "" "408.4" "367.7" "472.8" "409.4" "387.0" "530.6" "320.3" "417.4" "469.9" "167.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2150748430854839914" "False" "High" "IsMasterProtein" "Q96JC1" "Vam6/Vps39-like protein OS=Homo sapiens OX=9606 GN=VPS39 PE=1 SV=2" "0.000" "False" "8.162" "3" "3" "3" "3" "886" "101.7" "6.99" "8.29" "3" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf00780, Pf10366, Pf10367" "23339" "ENSG00000166887" "VPS39" "hsa:23339; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96JC1; Q96RM0" "VEGFA-VEGFR2 signaling; Ebola virus infection in host; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins" "SARS-CoV-2 modulates autophagy" "4" "0" "1.178" "1.259" "1.227" "1.447" "1.271" "1.296" "1.058" "1.247" "1.621" "67.4" "79.3" "84.8" "82.6" "97.5" "85.6" "87.3" "71.2" "84.0" "109.2" "" "" "" "" "" "" "" "" "" "" "60.6" "64.2" "76.7" "80.7" "80.5" "85.6" "65.4" "62.9" "75.2" "39.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "983128830238586266" "False" "High" "IsMasterProtein" "Q53F19" "Nuclear cap-binding protein subunit 3 OS=Homo sapiens OX=9606 GN=NCBP3 PE=1 SV=2" "0.000" "False" "8.159" "5" "3" "4" "3" "620" "70.5" "5.73" "8.12" "3" "RNA metabolism OR transcription;other metabolic processes;stress response;transport;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf10309" "55421" "ENSG00000074356" "NCBP3" "B3KWG7; hsa:55421; Q53F19; Q7L406; Q96FK1; Q9NXZ4" "" "" "0" "0" "1.054" "0.962" "1.003" "1.099" "1.007" "1.081" "1.076" "0.996" "2.099" "231.3" "243.8" "222.4" "231.9" "254.0" "232.9" "250.1" "248.7" "230.4" "485.5" "" "" "" "" "" "" "" "" "" "" "207.9" "197.3" "201.1" "226.3" "209.6" "232.9" "187.3" "219.7" "206.2" "173.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7379304699154124017" "False" "High" "IsMasterProtein" "Q7Z7C8" "Transcription initiation factor TFIID subunit 8 OS=Homo sapiens OX=9606 GN=TAF8 PE=1 SV=1" "0.000" "False" "8.153" "14" "3" "3" "3" "310" "34.2" "6.46" "9.54" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07524, Pf10406" "129685" "ENSG00000137413" "TAF8" "hsa:129685; Q5T0K1; Q7Z7C8; Q8N4R9; Q96M52" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.081" "1.083" "0.939" "0.927" "0.872" "0.723" "1.097" "0.947" "1.446" "402.3" "434.8" "435.7" "377.8" "372.8" "350.9" "291.0" "441.2" "381.0" "581.8" "" "" "" "" "" "" "" "" "" "" "361.7" "351.8" "394.1" "368.8" "307.7" "350.9" "217.9" "389.7" "340.9" "207.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7546150518504420539" "False" "High" "IsMasterProtein" "O00186" "Syntaxin-binding protein 3 OS=Homo sapiens OX=9606 GN=STXBP3 PE=1 SV=2" "0.000" "False" "8.144" "4" "3" "3" "3" "592" "67.7" "7.80" "10.30" "3" "cell adhesion;cell-cell signaling;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00995" "6814" "ENSG00000116266" "STXBP3" "A8K269; A8K5K7; hsa:6814; O00186; Q53FW1; Q86YJ3; Q9UPD7" "Insulin signaling" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Disinhibition of SNARE formation" "3" "0" "0.997" "0.963" "0.981" "0.994" "1.024" "1.061" "0.886" "1.000" "2.538" "329.1" "328.1" "316.8" "323.0" "327.0" "336.8" "349.2" "291.6" "329.1" "835.3" "" "" "" "" "" "" "" "" "" "" "295.9" "265.5" "286.6" "315.3" "269.8" "336.8" "261.5" "257.6" "294.5" "298.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3265591638708801395" "False" "High" "IsMasterProtein" "P62699" "Protein yippee-like 5 OS=Homo sapiens OX=9606 GN=YPEL5 PE=1 SV=1" "0.000" "False" "8.140" "21" "2" "2" "2" "121" "13.8" "7.31" "8.63" "2" "cell cycle OR cell proliferation" "non-structural extracellular;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03226" "51646" "ENSG00000119801" "YPEL5" "D6W568; hsa:51646; P62699; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9" "Ciliary landscape" "Neutrophil degranulation" "2" "0" "0.958" "0.929" "0.938" "0.993" "0.926" "0.995" "0.950" "0.957" "0.822" "145.7" "139.6" "135.4" "136.6" "144.6" "134.9" "144.9" "138.4" "139.4" "119.7" "" "" "" "" "" "" "" "" "" "" "131.0" "112.9" "122.5" "133.3" "119.3" "134.9" "108.5" "122.2" "124.7" "42.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2730791661393038830" "False" "High" "IsMasterProtein" "Q9Y3P8" "Signaling threshold-regulating transmembrane adapter 1 OS=Homo sapiens OX=9606 GN=SIT1 PE=1 SV=1" "0.000" "False" "8.133" "10" "2" "3" "2" "196" "21.1" "6.30" "8.83" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "" "27240" "ENSG00000137078" "SIT1" "B2RBP9; hsa:27240; Q9Y3P8" "" "" "0" "0" "1.009" "0.922" "0.952" "0.970" "0.887" "0.970" "1.054" "0.949" "0.596" "215.5" "217.4" "198.6" "205.1" "209.0" "191.1" "209.1" "227.2" "204.6" "128.3" "" "" "" "" "" "" "" "" "" "" "193.7" "175.9" "179.6" "200.2" "172.5" "191.1" "156.6" "200.7" "183.0" "45.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2290679747750258587" "False" "High" "IsMasterProtein" "P00973" "2'-5'-oligoadenylate synthase 1 OS=Homo sapiens OX=9606 GN=OAS1 PE=1 SV=4" "0.000" "False" "8.130" "3" "1" "2" "1" "400" "46.0" "8.22" "7.42" "1" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;mitochondrion;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf10421" "4938" "ENSG00000089127" "OAS1" "A8K4N8; F8VXY3; hsa:4938; P00973; P04820; P29080; P29081; P78485; P78486; Q16700; Q16701; Q1PG42; Q3ZM01; Q53GC5; Q53YA4; Q6A1Z3; Q6IPC6; Q6P7N9; Q96J61" "Immune response to tuberculosis; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Type II interferon signaling" "OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling" "8" "0" "1.352" "0.945" "0.936" "1.338" "1.124" "0.887" "0.919" "1.062" "0.946" "48.5" "65.6" "45.8" "45.4" "64.9" "54.5" "43.1" "44.6" "51.5" "45.9" "" "" "" "" "" "" "" "" "" "" "43.6" "53.1" "41.5" "44.3" "53.6" "54.5" "32.2" "39.4" "46.1" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1936196132069053391" "False" "High" "IsMasterProtein" "Q8WXA9" "Splicing regulatory glutamine/lysine-rich protein 1 OS=Homo sapiens OX=9606 GN=SREK1 PE=1 SV=1" "0.000" "False" "8.129" "5" "2" "2" "2" "508" "59.3" "10.39" "8.76" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf00076" "140890" "ENSG00000153914" "SREK1" "A4FTW3; hsa:140890; Q2M1J0; Q86X37; Q8WXA9" "mRNA processing" "" "1" "0" "1.025" "0.979" "1.025" "1.027" "1.157" "1.054" "1.053" "0.933" "1.226" "191.9" "196.7" "188.0" "196.7" "197.0" "222.0" "202.2" "202.1" "179.1" "235.2" "" "" "" "" "" "" "" "" "" "" "172.6" "159.1" "170.0" "192.0" "162.6" "222.0" "151.4" "178.5" "160.3" "84.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7076212038765232147" "False" "High" "IsMasterProtein" "Q96RR1" "Twinkle mtDNA helicase OS=Homo sapiens OX=9606 GN=TWNK PE=1 SV=1" "0.000" "False" "8.118" "5" "2" "2" "2" "684" "77.1" "8.98" "6.74" "2" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf13481" "56652" "ENSG00000107815" "TWNK" "B2CQL2; hsa:56652; Q6MZX2; Q6PJP5; Q96RR0; Q96RR1" "Primary ovarian insufficiency" "Transcriptional activation of mitochondrial biogenesis; Mitochondrial protein degradation" "3" "0" "1.137" "1.098" "1.069" "1.005" "1.098" "1.129" "1.040" "1.024" "1.274" "156.6" "178.1" "172.0" "167.5" "157.4" "172.0" "176.8" "162.9" "160.4" "199.6" "" "" "" "" "" "" "" "" "" "" "140.8" "144.1" "155.6" "163.5" "129.9" "172.0" "132.4" "143.9" "143.5" "71.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6162368025994279371" "False" "High" "IsMasterProtein" "Q13395" "Probable methyltransferase TARBP1 OS=Homo sapiens OX=9606 GN=TARBP1 PE=1 SV=1" "0.000" "False" "8.110" "2" "3" "3" "3" "1621" "181.6" "7.05" "10.10" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00588" "6894" "ENSG00000059588" "TARBP1" "hsa:6894; Q13395; Q9H581" "" "" "0" "0" "0.984" "0.892" "0.944" "1.096" "0.997" "1.078" "1.022" "0.951" "1.060" "90.8" "89.4" "81.0" "85.8" "99.6" "90.6" "98.0" "92.8" "86.4" "96.3" "" "" "" "" "" "" "" "" "" "" "81.7" "72.3" "73.3" "83.7" "82.2" "90.6" "73.4" "82.0" "77.3" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7105590479105363220" "False" "High" "IsMasterProtein" "O60870" "DNA/RNA-binding protein KIN17 OS=Homo sapiens OX=9606 GN=KIN PE=1 SV=2" "0.000" "False" "8.096" "9" "3" "3" "3" "393" "45.3" "8.95" "7.24" "3" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10357, Pf18131" "22944" "ENSG00000151657" "KIN" "B4DX32; hsa:22944; O60870" "" "Protein methylation" "1" "0" "1.013" "0.980" "1.030" "1.072" "1.069" "1.114" "0.971" "0.998" "1.642" "158.3" "160.4" "155.2" "163.1" "169.8" "169.3" "176.4" "153.7" "158.0" "259.9" "" "" "" "" "" "" "" "" "" "" "142.3" "129.8" "140.3" "159.2" "140.1" "169.3" "132.1" "135.7" "141.3" "92.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7630345377865006626" "False" "High" "IsMasterProtein" "Q9NVS9" "Pyridoxine-5'-phosphate oxidase OS=Homo sapiens OX=9606 GN=PNPO PE=1 SV=1" "0.000" "False" "8.095" "9" "2" "2" "2" "261" "30.0" "7.06" "7.25" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01243, Pf10590" "55163" "ENSG00000108439" "PNPO" "B4E0V0; B4E152; B4E1D7; D3DTT9; hsa:55163; Q9NVS9" "Selenium micronutrient network; Vitamin B6-dependent and responsive disorders" "Vitamin B6 activation to pyridoxal phosphate" "3" "0" "0.852" "0.900" "0.958" "0.948" "0.950" "0.922" "0.887" "0.966" "0.891" "146.8" "125.0" "132.1" "140.6" "139.1" "139.4" "135.3" "130.1" "141.7" "130.7" "" "" "" "" "" "" "" "" "" "" "131.9" "101.2" "119.5" "137.2" "114.8" "139.4" "101.3" "114.9" "126.8" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1025854285268432181" "False" "High" "IsMasterProtein" "P56377" "AP-1 complex subunit sigma-2 OS=Homo sapiens OX=9606 GN=AP1S2 PE=1 SV=1" "0.000" "False" "8.091" "21" "3" "3" "2" "157" "18.6" "5.47" "8.70" "3" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "8905" "ENSG00000182287" "AP1S2" "B4DSU4; hsa:8905; O95326; P56377; Q9H2N6" "" "Golgi Associated Vesicle Biogenesis; MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.027" "1.072" "0.880" "0.937" "1.024" "1.145" "0.937" "0.985" "1.207" "70.1" "72.0" "75.2" "61.7" "65.7" "71.8" "80.3" "65.7" "69.1" "84.6" "" "" "" "" "" "" "" "" "" "" "63.0" "58.3" "68.0" "60.3" "54.3" "71.8" "60.1" "58.0" "61.8" "30.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2326437507521645462" "False" "High" "IsMasterProtein" "Q9P2W1" "Homologous-pairing protein 2 homolog OS=Homo sapiens OX=9606 GN=PSMC3IP PE=1 SV=1" "0.000" "False" "8.085" "13" "2" "2" "2" "217" "24.9" "7.81" "5.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07106, Pf18517" "29893" "ENSG00000131470" "PSMC3IP" "C5ILB7; hsa:29893; Q14458; Q8WXG2; Q96HA2; Q9P2W1" "Androgen receptor signaling pathway; Primary ovarian insufficiency" "Meiotic recombination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5793722554403523201" "False" "High" "IsMasterProtein" "Q14764" "Major vault protein OS=Homo sapiens OX=9606 GN=MVP PE=1 SV=4" "0.000" "False" "8.083" "5" "4" "4" "4" "893" "99.3" "5.48" "4.47" "4" "transport;signal transduction;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf01505, Pf11978, Pf17794, Pf17795, Pf17796" "9961" "ENSG00000013364" "MVP" "hsa:9961; Q14764; Q96BG4; Q9BPW6; Q9BQT1; Q9UBD1" "16p11.2 proximal deletion syndrome" "Neutrophil degranulation" "2" "0" "1.082" "1.095" "1.145" "1.082" "0.887" "1.089" "1.078" "1.076" "0.983" "168.0" "181.7" "183.9" "192.4" "181.8" "149.0" "182.9" "181.0" "180.7" "165.1" "" "" "" "" "" "" "" "" "" "" "151.0" "147.0" "166.4" "187.8" "150.0" "149.0" "136.9" "159.9" "161.7" "58.9" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6536357785872288465" "False" "High" "IsMasterProtein" "P48723" "Heat shock 70 kDa protein 13 OS=Homo sapiens OX=9606 GN=HSPA13 PE=1 SV=1" "0.000" "False" "8.080" "6" "2" "2" "2" "471" "51.9" "5.76" "8.26" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00012" "6782" "ENSG00000155304" "HSPA13" "B2R616; hsa:6782; P48723; Q8NE40" "" "Regulation of HSF1-mediated heat shock response" "1" "0" "1.009" "1.145" "1.014" "1.206" "1.129" "1.105" "1.086" "1.093" "1.405" "150.9" "152.3" "172.8" "153.1" "182.0" "170.4" "166.8" "163.9" "165.0" "212.1" "" "" "" "" "" "" "" "" "" "" "135.7" "123.2" "156.3" "149.4" "150.2" "170.4" "124.9" "144.7" "147.6" "75.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4782042828393349132" "False" "High" "IsMasterProtein" "P52756" "RNA-binding protein 5 OS=Homo sapiens OX=9606 GN=RBM5 PE=1 SV=2" "0.000" "False" "8.065" "3" "2" "2" "2" "815" "92.1" "6.28" "7.15" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf00641, Pf01585, Pf17780" "10181" "ENSG00000003756" "RBM5" "B2RA45; B4DM16; B4DMF9; B4DZ63; hsa:10181; P52756; Q93021; Q9BU14; Q9HDA6; Q9UKY8; Q9UL24" "mRNA processing" "mRNA Splicing - Major Pathway" "2" "0" "1.065" "1.065" "0.889" "1.212" "1.144" "1.199" "1.013" "1.109" "2.098" "97.0" "103.4" "103.4" "86.2" "117.7" "111.0" "116.4" "98.3" "107.6" "203.5" "" "" "" "" "" "" "" "" "" "" "87.2" "83.7" "93.5" "84.2" "97.1" "111.0" "87.1" "86.8" "96.3" "72.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8567537084386512250" "False" "High" "IsMasterProtein" "P20933" "N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Homo sapiens OX=9606 GN=AGA PE=1 SV=2" "0.000" "False" "8.064" "9" "2" "2" "2" "346" "37.2" "6.28" "7.20" "2" "protein metabolism;other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01112" "175" "ENSG00000038002" "AGA" "B2R7H2; D3DP47; hsa:175; P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8" "" "Neutrophil degranulation" "1" "0" "0.943" "0.835" "0.885" "0.946" "0.926" "0.808" "0.992" "0.914" "0.783" "174.3" "164.4" "145.5" "154.2" "164.8" "161.3" "140.8" "172.9" "159.3" "136.5" "" "" "" "" "" "" "" "" "" "" "156.7" "133.1" "131.6" "150.5" "136.0" "161.3" "105.5" "152.7" "142.6" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4457923418212220439" "False" "High" "IsMasterProtein" "O60499" "Syntaxin-10 OS=Homo sapiens OX=9606 GN=STX10 PE=1 SV=1" "0.000" "False" "8.059" "8" "2" "3" "1" "249" "28.1" "4.89" "9.42" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf05739, Pf09177" "8677" "ENSG00000104915" "STX10" "A6NC41; hsa:8677; O60499; Q6IAP4; Q96AE8" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2429819292905121696" "False" "High" "IsMasterProtein" "P57077" "MAP3K7 C-terminal-like protein OS=Homo sapiens OX=9606 GN=MAP3K7CL PE=1 SV=2" "0.000" "False" "8.045" "16" "2" "2" "2" "142" "16.4" "4.89" "9.08" "2" "" "" "" "" "56911" "ENSG00000156265; ENSG00000291525" "MAP3K7CL" "D3DSE0; hsa:56911; P57077; Q8TCL9" "" "" "0" "0" "1.009" "1.284" "1.182" "1.050" "1.208" "1.142" "1.280" "1.134" "1.075" "55.0" "55.5" "70.6" "64.9" "57.7" "66.4" "62.7" "70.3" "62.3" "59.1" "" "" "" "" "" "" "" "" "" "" "49.4" "44.9" "63.8" "63.4" "47.6" "66.4" "47.0" "62.1" "55.7" "21.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3090856641429635389" "False" "High" "IsMasterProtein" "Q16637" "Survival motor neuron protein OS=Homo sapiens OX=9606 GN=SMN2 PE=1 SV=1" "0.000" "False" "8.038" "10" "2" "2" "2" "294" "31.8" "6.55" "9.39" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06003, Pf20635, Pf20636" "6606; 6607" "ENSG00000172062; ENSG00000205571; ENSG00000273772; ENSG00000275349; ENSG00000277773" "SMN1; SMN2" "A8K0V4; hsa:6606; hsa:6607; Q13119; Q16637; Q549U5; Q96J51" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "0.964" "0.809" "0.876" "0.959" "0.851" "0.888" "0.881" "0.749" "1.437" "207.9" "200.4" "168.2" "182.1" "199.4" "176.9" "184.7" "183.1" "155.7" "298.6" "" "" "" "" "" "" "" "" "" "" "186.9" "162.2" "152.1" "177.7" "164.6" "176.9" "138.3" "161.7" "139.3" "106.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2555590194794136668" "False" "High" "IsMasterProtein" "Q9C073" "Protein FAM117A OS=Homo sapiens OX=9606 GN=FAM117A PE=1 SV=1" "0.000" "False" "8.029" "5" "2" "2" "2" "453" "48.3" "8.31" "8.24" "2" "" "" "" "Pf15388" "81558" "ENSG00000121104" "FAM117A" "B7Z7Q3; hsa:81558; Q9C073" "" "" "0" "0" "1.014" "1.284" "1.109" "1.328" "1.167" "1.054" "1.071" "1.249" "1.008" "43.6" "44.2" "56.0" "48.4" "57.9" "50.9" "45.9" "46.7" "54.5" "44.0" "" "" "" "" "" "" "" "" "" "" "39.2" "35.8" "50.6" "47.2" "47.8" "50.9" "34.4" "41.2" "48.7" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2541081725476023529" "False" "High" "IsMasterProtein" "Q8NBJ7" "Inactive C-alpha-formylglycine-generating enzyme 2 OS=Homo sapiens OX=9606 GN=SUMF2 PE=1 SV=2" "0.000" "False" "8.025" "7" "2" "4" "2" "301" "33.8" "8.00" "11.45" "2" "" "ER/Golgi" "other molecular function" "Pf03781" "25870" "ENSG00000129103" "SUMF2" "B4DU41; B4DWQ0; hsa:25870; Q14DW5; Q53ZE3; Q8NBJ7; Q96BH2; Q9BRN3; Q9BWI1; Q9Y405" "" "Glycosphingolipid catabolism; The activation of arylsulfatases" "2" "0" "1.085" "1.056" "1.096" "1.063" "1.058" "1.203" "0.970" "1.020" "1.474" "351.8" "381.8" "371.5" "385.7" "374.0" "372.3" "423.1" "341.1" "358.7" "518.6" "" "" "" "" "" "" "" "" "" "" "316.3" "308.9" "336.0" "376.5" "308.6" "372.3" "316.8" "301.3" "321.0" "185.1" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892747589052197154" "False" "High" "IsMasterProtein" "Q5W0B1" "ORC ubiquitin ligase 1 OS=Homo sapiens OX=9606 GN=OBI1 PE=1 SV=1" "0.000" "False" "8.020" "4" "3" "3" "3" "726" "81.1" "5.72" "6.76" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf13923" "79596" "ENSG00000152193" "OBI1" "B2RN99; hsa:79596; Q5W0B1; Q8TBY2; Q9H0T2; Q9H8M0" "" "" "0" "0" "1.023" "1.098" "1.021" "1.004" "1.036" "1.130" "1.023" "1.023" "1.638" "208.7" "213.5" "229.1" "213.0" "209.6" "216.2" "235.9" "213.4" "213.5" "342.0" "" "" "" "" "" "" "" "" "" "" "187.7" "172.8" "207.2" "207.9" "173.0" "216.2" "176.7" "188.5" "191.0" "122.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2132288438487461579" "False" "High" "IsMasterProtein" "Q9BV68" "E3 ubiquitin-protein ligase RNF126 OS=Homo sapiens OX=9606 GN=RNF126 PE=1 SV=2" "0.000" "False" "8.016" "7" "2" "2" "2" "311" "33.8" "5.47" "9.32" "2" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf13639, Pf14369" "55658" "ENSG00000070423" "RNF126" "hsa:55658; Q9BV68; Q9NWX1" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.825" "0.864" "0.910" "0.914" "0.892" "1.019" "0.868" "0.948" "1.345" "182.2" "150.3" "157.4" "165.9" "166.6" "162.5" "185.8" "158.3" "172.7" "245.0" "" "" "" "" "" "" "" "" "" "" "163.8" "121.7" "142.4" "161.9" "137.5" "162.5" "139.1" "139.8" "154.5" "87.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "563724113440254403" "False" "High" "IsMasterProtein" "Q7Z6J4" "FYVE, RhoGEF and PH domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FGD2 PE=1 SV=1" "0.000" "False" "8.012" "5" "2" "2" "2" "655" "74.8" "6.93" "7.86" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "221472" "ENSG00000146192" "FGD2" "hsa:221472; Q5T8I1; Q6P6A8; Q6ZNL5; Q7Z6J4; Q8IZ32; Q8N868; Q9H7M2" "" "CDC42 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "3" "0" "1.398" "1.216" "1.226" "1.283" "1.282" "1.172" "1.155" "1.204" "3.049" "98.9" "138.3" "120.2" "121.3" "126.9" "126.8" "115.9" "114.3" "119.1" "301.6" "" "" "" "" "" "" "" "" "" "" "88.9" "111.9" "108.8" "118.4" "104.8" "126.8" "86.8" "101.0" "106.6" "107.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8206347650273111002" "False" "High" "IsMasterProtein" "Q9H7C9" "Mth938 domain-containing protein OS=Homo sapiens OX=9606 GN=AAMDC PE=1 SV=1" "0.000" "False" "8.007" "20" "2" "2" "2" "122" "13.3" "8.46" "9.14" "2" "other biological processes" "other cell component" "" "Pf04430" "28971" "ENSG00000087884" "AAMDC" "hsa:28971; Q96AQ4; Q9H7C9; Q9Y6B1" "" "" "0" "0" "0.958" "1.039" "1.003" "1.011" "1.040" "1.012" "1.133" "0.979" "0.754" "147.5" "141.3" "153.2" "147.9" "149.1" "153.4" "149.2" "167.1" "144.3" "111.2" "" "" "" "" "" "" "" "" "" "" "132.6" "114.4" "138.5" "144.4" "123.1" "153.4" "111.7" "147.6" "129.1" "39.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6664937440056635092" "False" "High" "IsMasterProtein" "Q9BQ48" "Large ribosomal subunit protein bL34m OS=Homo sapiens OX=9606 GN=MRPL34 PE=1 SV=1" "0.000" "False" "8.007" "24" "2" "2" "2" "92" "10.2" "12.25" "7.89" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00468" "64981" "ENSG00000130312" "MRPL34" "hsa:64981; Q9BQ48" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.906" "0.918" "1.065" "0.947" "0.981" "0.983" "0.962" "0.884" "0.770" "216.9" "196.4" "199.2" "231.0" "205.3" "212.8" "213.3" "208.6" "191.8" "167.0" "" "" "" "" "" "" "" "" "" "" "195.0" "158.9" "180.2" "225.5" "169.4" "212.8" "159.7" "184.3" "171.6" "59.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8081850607027736323" "False" "High" "IsMasterProtein" "Q9P0J1" "[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PDP1 PE=1 SV=3" "0.000" "False" "8.005" "4" "2" "2" "2" "537" "61.0" "6.67" "7.73" "2" "protein metabolism;other metabolic processes" "mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00481" "54704" "ENSG00000164951" "PDP1" "B3KX71; hsa:54704; J3KPU0; Q5U5K1; Q9P0J1" "Orexin receptor pathway; Glucose metabolism in triple-negative breast cancer cells" "Regulation of pyruvate dehydrogenase (PDH) complex" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7852506099469631666" "False" "High" "IsMasterProtein" "Q9H7D0" "Dedicator of cytokinesis protein 5 OS=Homo sapiens OX=9606 GN=DOCK5 PE=1 SV=3" "0.000" "False" "8.001" "1" "3" "4" "1" "1870" "215.2" "7.96" "8.16" "3" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf06920, Pf14429, Pf16172, Pf20421, Pf20422" "80005" "ENSG00000147459" "DOCK5" "B2RNY0; hsa:80005; Q5XKD5; Q6AI11; Q6PJS6; Q6ZTS6; Q9H7D0" "Ciliary landscape" "Factors involved in megakaryocyte development and platelet production; RAC1 GTPase cycle; RHOG GTPase cycle" "4" "0" "0.882" "1.070" "0.996" "0.959" "0.818" "0.934" "0.938" "0.887" "4.371" "94.5" "83.4" "101.1" "94.2" "90.7" "77.3" "88.3" "88.7" "83.9" "413.3" "" "" "" "" "" "" "" "" "" "" "85.0" "67.5" "91.5" "91.9" "74.8" "77.3" "66.1" "78.3" "75.1" "147.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8316200197019601200" "False" "High" "IsMasterProtein" "Q9Y3I1" "F-box only protein 7 OS=Homo sapiens OX=9606 GN=FBXO7 PE=1 SV=1" "0.000" "False" "7.994" "8" "4" "4" "4" "522" "58.5" "6.55" "8.13" "4" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00646, Pf11566" "25793" "ENSG00000100225" "FBXO7" "B4DNB3; B4DWX5; hsa:25793; Q5TGC4; Q5TI86; Q96HM6; Q9UF21; Q9UKT2; Q9Y3I1" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.067" "1.104" "1.038" "1.109" "1.148" "1.020" "1.037" "1.128" "1.529" "419.6" "447.8" "463.3" "435.4" "465.1" "481.5" "427.9" "435.0" "473.2" "641.3" "" "" "" "" "" "" "" "" "" "" "377.2" "362.3" "419.1" "425.1" "383.8" "481.5" "320.4" "384.2" "423.5" "228.9" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6133678444779992417" "False" "High" "IsMasterProtein" "Q9UGU0" "Transcription factor 20 OS=Homo sapiens OX=9606 GN=TCF20 PE=1 SV=3" "0.000" "False" "7.985" "2" "4" "5" "4" "1960" "211.6" "9.04" "10.01" "4" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13771" "6942" "ENSG00000100207; ENSG00000262024; ENSG00000276461" "TCF20" "A9JX12; hsa:6942; O14528; Q13078; Q4V353; Q9H4M0; Q9UGU0" "Matrix metalloproteinases" "" "1" "0" "1.014" "0.974" "0.898" "1.058" "0.969" "1.089" "1.065" "0.804" "0.956" "309.6" "313.9" "301.6" "278.0" "327.7" "299.9" "337.1" "329.9" "249.1" "296.1" "" "" "" "" "" "" "" "" "" "" "278.4" "254.0" "272.8" "271.3" "270.4" "299.9" "252.4" "291.4" "222.9" "105.7" "4" "4" "4" "4" "4" "4" "4" "4" "4" "4" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479152358026622907" "False" "High" "IsMasterProtein" "Q8WV74" "Mitochondrial coenzyme A diphosphatase NUDT8 OS=Homo sapiens OX=9606 GN=NUDT8 PE=1 SV=2" "0.000" "False" "7.981" "11" "2" "2" "2" "236" "25.4" "8.41" "7.87" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00293" "254552" "ENSG00000167799" "NUDT8" "hsa:254552; Q6ZW59; Q8WV74" "" "Vitamin B5 (pantothenate) metabolism" "1" "0" "1.209" "1.111" "1.027" "1.037" "1.294" "1.182" "1.240" "1.033" "0.867" "72.3" "87.5" "80.4" "74.3" "75.0" "93.6" "85.5" "89.7" "74.7" "62.7" "" "" "" "" "" "" "" "" "" "" "65.0" "70.8" "72.7" "72.5" "61.9" "93.6" "64.0" "79.2" "66.8" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9157929292758815644" "False" "High" "IsMasterProtein" "Q96A35" "Large ribosomal subunit protein uL24m OS=Homo sapiens OX=9606 GN=MRPL24 PE=1 SV=1" "0.000" "False" "7.970" "17" "3" "3" "3" "216" "24.9" "9.29" "9.76" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00467, Pf17136" "79590" "ENSG00000143314" "MRPL24" "D3DVC8; hsa:79590; Q53G65; Q53HT0; Q5SYZ9; Q5SZ00; Q5SZ02; Q96A35; Q96Q70; Q9H7G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.031" "0.824" "0.879" "0.832" "0.791" "0.853" "0.791" "0.791" "0.978" "119.6" "123.2" "98.6" "105.1" "99.4" "94.6" "102.0" "94.6" "94.6" "117.0" "" "" "" "" "" "" "" "" "" "" "107.5" "99.7" "89.2" "102.6" "82.1" "94.6" "76.4" "83.5" "84.6" "41.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4527402495997135849" "False" "High" "IsMasterProtein" "Q08AG7" "Mitotic-spindle organizing protein 1 OS=Homo sapiens OX=9606 GN=MZT1 PE=1 SV=2" "0.000" "False" "7.969" "33" "2" "2" "2" "82" "8.5" "4.78" "9.41" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "" "Pf12554" "440145" "ENSG00000204899" "MZT1" "hsa:440145; Q08AG7; Q5W0P5" "" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "2" "0" "0.979" "0.951" "0.936" "0.952" "0.965" "0.913" "1.009" "0.988" "1.256" "174.7" "171.0" "166.1" "163.5" "166.4" "168.6" "159.5" "176.2" "172.5" "219.4" "" "" "" "" "" "" "" "" "" "" "157.1" "138.3" "150.2" "159.6" "137.3" "168.6" "119.4" "155.6" "154.4" "78.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9028825818345530826" "False" "High" "IsMasterProtein" "Q9UNZ5" "Leydig cell tumor 10 kDa protein homolog OS=Homo sapiens OX=9606 GN=C19orf53 PE=1 SV=1" "0.000" "False" "7.968" "26" "3" "4" "3" "99" "10.6" "11.55" "12.04" "3" "" "" "" "Pf09495" "28974" "ENSG00000104979" "C19orf53" "B2R4J9; hsa:28974; Q9UNZ5" "" "" "0" "0" "0.990" "0.909" "0.891" "0.806" "0.940" "0.776" "0.846" "0.780" "0.766" "350.2" "346.6" "318.2" "312.1" "282.3" "329.3" "271.7" "296.2" "273.2" "268.3" "" "" "" "" "" "" "" "" "" "" "314.8" "280.4" "287.9" "304.6" "233.0" "329.3" "203.5" "261.7" "244.5" "95.8" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6897785543843873721" "False" "High" "IsMasterProtein" "Q7Z5J4" "Retinoic acid-induced protein 1 OS=Homo sapiens OX=9606 GN=RAI1 PE=1 SV=2" "0.000" "False" "7.967" "2" "2" "2" "2" "1906" "203.2" "8.79" "7.91" "2" "developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13771" "10743" "ENSG00000108557" "RAI1" "hsa:10743; Q7Z5J4; Q8N3B4; Q8ND08; Q8WU64; Q96JK5; Q9H1C1; Q9H1C2; Q9UF69" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Heme signaling; Circadian Clock" "3" "0" "1.023" "0.937" "1.065" "1.091" "0.977" "1.005" "1.035" "0.904" "0.811" "177.4" "181.5" "166.2" "189.0" "193.5" "173.3" "178.4" "183.6" "160.4" "143.8" "" "" "" "" "" "" "" "" "" "" "159.5" "146.8" "150.4" "184.5" "159.7" "173.3" "133.6" "162.1" "143.5" "51.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7252282534917135675" "False" "High" "IsMasterProtein" "Q15542" "Transcription initiation factor TFIID subunit 5 OS=Homo sapiens OX=9606 GN=TAF5 PE=1 SV=3" "0.000" "False" "7.966" "4" "4" "4" "4" "800" "86.8" "5.64" "10.41" "4" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "6877" "ENSG00000148835" "TAF5" "A8K5B4; B2RMR0; B7ZKJ6; hsa:6877; Q15542; Q53EM4; Q5SYD5; Q86UZ7; Q9Y4K5" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "1.054" "0.911" "1.057" "1.027" "0.908" "1.350" "0.875" "0.896" "1.890" "68.7" "72.4" "62.6" "72.6" "70.6" "62.4" "92.8" "60.2" "61.6" "129.9" "" "" "" "" "" "" "" "" "" "" "61.8" "58.6" "56.6" "70.9" "58.2" "62.4" "69.5" "53.1" "55.1" "46.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3538958500289371582" "False" "High" "IsMasterProtein" "P49336" "Cyclin-dependent kinase 8 OS=Homo sapiens OX=9606 GN=CDK8 PE=1 SV=1" "0.000" "False" "7.961" "6" "3" "3" "2" "464" "53.3" "8.57" "10.30" "3" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "1024" "ENSG00000132964" "CDK8" "hsa:1024; P49336; Q5VUF3; Q6ISB5" "Sterol regulatory element-binding proteins (SREBP) signaling; H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; lncRNA in canonical Wnt signaling and colorectal cancer" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NOTCH1 Intracellular Domain Regulates Transcription" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3817114050720704856" "False" "High" "IsMasterProtein" "Q9H867" "Protein N-lysine methyltransferase METTL21D OS=Homo sapiens OX=9606 GN=VCPKMT PE=1 SV=2" "0.000" "False" "7.955" "11" "2" "2" "2" "229" "25.8" "4.92" "8.62" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf10294" "79609" "ENSG00000100483" "VCPKMT" "B7ZLA3; B7ZLA4; hsa:79609; Q2M2X3; Q86T12; Q9H867" "" "Protein methylation" "1" "0" "1.224" "0.962" "1.021" "1.379" "1.146" "1.186" "1.421" "1.431" "1.325" "27.7" "33.9" "26.6" "28.3" "38.2" "31.7" "32.8" "39.3" "39.6" "36.7" "" "" "" "" "" "" "" "" "" "" "24.9" "27.4" "24.1" "27.6" "31.5" "31.7" "24.6" "34.7" "35.5" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624164927491725104" "False" "High" "IsMasterProtein" "O75449" "Katanin p60 ATPase-containing subunit A1 OS=Homo sapiens OX=9606 GN=KATNA1 PE=1 SV=1" "0.000" "False" "7.949" "8" "4" "4" "2" "491" "55.9" "6.90" "12.06" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00004, Pf09336, Pf17862, Pf21126" "11104" "ENSG00000186625" "KATNA1" "E1P5A3; hsa:11104; O75449; Q5TFA8; Q5TFA9; Q86VN2; Q9NU52" "" "" "0" "0" "1.318" "0.840" "0.804" "1.091" "0.970" "0.943" "0.951" "1.006" "0.624" "104.4" "137.5" "87.6" "83.9" "113.8" "101.3" "98.4" "99.3" "105.0" "65.1" "" "" "" "" "" "" "" "" "" "" "93.8" "111.3" "79.3" "81.9" "93.9" "101.3" "73.7" "87.7" "93.9" "23.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4814601069630724909" "False" "High" "IsMasterProtein" "Q15906" "Vacuolar protein sorting-associated protein 72 homolog OS=Homo sapiens OX=9606 GN=VPS72 PE=1 SV=1" "0.000" "False" "7.940" "7" "2" "2" "2" "364" "40.6" "6.48" "6.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05764, Pf08265" "6944" "ENSG00000163159" "VPS72" "A6NLK9; A6PW55; hsa:6944; Q15906; Q53GJ2; Q5U0R4" "" "HATs acetylate histones" "1" "0" "0.978" "1.120" "0.756" "0.935" "0.872" "0.943" "0.862" "0.948" "1.146" "84.1" "82.3" "94.3" "63.6" "78.7" "73.3" "79.3" "72.5" "79.8" "96.4" "" "" "" "" "" "" "" "" "" "" "75.7" "66.6" "85.3" "62.1" "64.9" "73.3" "59.4" "64.1" "71.4" "34.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5633919100605792812" "False" "High" "IsMasterProtein" "O43482" "Protein Mis18-beta OS=Homo sapiens OX=9606 GN=OIP5 PE=1 SV=2" "0.000" "False" "7.933" "17" "2" "2" "2" "229" "24.7" "7.37" "7.76" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03226" "11339" "ENSG00000104147" "OIP5" "hsa:11339; O43482; Q96BX7" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "1.009" "0.945" "0.851" "1.062" "0.992" "1.038" "0.951" "0.890" "0.897" "95.2" "96.1" "90.0" "81.0" "101.1" "94.4" "98.8" "90.5" "84.7" "85.3" "" "" "" "" "" "" "" "" "" "" "85.6" "77.7" "81.4" "79.0" "83.4" "94.4" "74.0" "80.0" "75.8" "30.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1844756928667547842" "False" "High" "IsMasterProtein" "Q9NWU1" "3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Homo sapiens OX=9606 GN=OXSM PE=1 SV=1" "0.000" "False" "7.924" "5" "2" "2" "2" "459" "48.8" "7.66" "7.50" "2" "other metabolic processes" "cytosol;mitochondrion" "other molecular function" "Pf00109, Pf02801" "54995" "ENSG00000151093" "OXSM" "Q9NWU1" "Mitochondrial fatty acid synthesis pathway" "Mitochondrial protein degradation" "2" "0" "1.058" "0.971" "0.889" "0.971" "0.969" "1.028" "0.917" "0.965" "0.753" "291.6" "308.5" "283.1" "259.4" "283.1" "282.7" "299.8" "267.5" "281.4" "219.7" "" "" "" "" "" "" "" "" "" "" "262.2" "249.6" "256.0" "253.2" "233.6" "282.7" "224.5" "236.3" "251.8" "78.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1443587214663370681" "False" "High" "IsMasterProtein" "Q9UKD1" "Glucocorticoid modulatory element-binding protein 2 OS=Homo sapiens OX=9606 GN=GMEB2 PE=1 SV=1" "0.000" "False" "7.898" "6" "3" "3" "2" "530" "56.4" "5.60" "10.54" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01342" "26205" "ENSG00000101216" "GMEB2" "E1P5J3; hsa:26205; Q5TDS0; Q9H431; Q9H4X7; Q9H4X8; Q9UF78; Q9UKD1; Q9ULF1" "" "" "0" "0" "1.047" "1.051" "1.015" "1.131" "1.137" "1.053" "1.136" "1.129" "1.373" "153.5" "160.7" "161.2" "155.8" "173.5" "174.5" "161.6" "174.3" "173.2" "210.8" "" "" "" "" "" "" "" "" "" "" "138.0" "130.0" "145.8" "152.1" "143.2" "174.5" "121.0" "154.0" "155.0" "75.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-727224885467951098" "False" "High" "IsMasterProtein" "O75925" "E3 SUMO-protein ligase PIAS1 OS=Homo sapiens OX=9606 GN=PIAS1 PE=1 SV=2" "0.000" "False" "7.892" "2" "1" "2" "1" "651" "71.8" "7.30" "9.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02891, Pf14324" "8554" "ENSG00000033800" "PIAS1" "B2RB67; B3KSY9; C5J4B4; hsa:8554; O75925; Q147X4; Q99751; Q9UN02" "Androgen receptor signaling pathway; Interleukin-11 signaling pathway; Mesodermal commitment pathway; TGF-beta signaling pathway; Immune response to tuberculosis; Interferon type I signaling pathways" "SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of transcription cofactors; SUMOylation of intracellular receptors; Regulation of IFNG signaling; SUMOylation of transcription factors; Formation of Incision Complex in GG-NER" "14" "0" "0.990" "0.884" "1.036" "0.898" "0.944" "0.887" "0.825" "0.940" "1.550" "81.8" "80.9" "72.3" "84.7" "73.5" "77.2" "72.6" "67.4" "76.8" "126.8" "" "" "" "" "" "" "" "" "" "" "73.5" "65.5" "65.4" "82.7" "60.6" "77.2" "54.3" "59.6" "68.7" "45.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-401785042072942350" "False" "High" "IsMasterProtein" "O94808" "Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Homo sapiens OX=9606 GN=GFPT2 PE=1 SV=3" "0.000" "False" "7.890" "3" "3" "5" "1" "682" "76.9" "7.37" "14.64" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf01380, Pf13522" "9945" "ENSG00000131459" "GFPT2" "hsa:9945; O94808; Q53XM2; Q9BWS4" "" "Synthesis of UDP-N-acetyl-glucosamine" "1" "0" "0.850" "0.892" "0.929" "1.041" "0.770" "0.962" "1.039" "1.081" "1.023" "122.2" "103.9" "109.0" "113.6" "127.3" "94.1" "117.6" "127.0" "132.1" "125.1" "" "" "" "" "" "" "" "" "" "" "109.9" "84.1" "98.6" "110.9" "105.0" "94.1" "88.1" "112.2" "118.2" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-332338773626550486" "False" "High" "IsMasterProtein" "Q9BQI3" "Eukaryotic translation initiation factor 2-alpha kinase 1 OS=Homo sapiens OX=9606 GN=EIF2AK1 PE=1 SV=2" "0.000" "False" "7.882" "5" "3" "3" "3" "630" "71.1" "5.99" "9.24" "3" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "27102" "ENSG00000086232" "EIF2AK1" "A8K2R2; hsa:27102; Q549K6; Q8NBW3; Q9BQI3; Q9HC02; Q9NYE0; Q9P0V6; Q9P1J5; Q9P2H8; Q9UHG4" "Translation factors; Measles virus infection" "Response of EIF2AK1 (HRI) to heme deficiency; Cellular response to mitochondrial stress" "4" "0" "0.991" "0.976" "0.883" "0.977" "1.047" "0.840" "0.934" "0.882" "0.808" "81.2" "80.4" "79.2" "71.6" "79.3" "84.9" "68.2" "75.8" "71.5" "65.6" "" "" "" "" "" "" "" "" "" "" "73.0" "65.0" "71.6" "69.9" "65.4" "84.9" "51.1" "66.9" "64.0" "23.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4297435359722797915" "False" "High" "IsMasterProtein" "Q99755" "Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Homo sapiens OX=9606 GN=PIP5K1A PE=1 SV=1" "0.000" "False" "7.879" "4" "2" "2" "2" "562" "62.6" "8.21" "8.75" "2" "cell adhesion;cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf01504" "8394" "ENSG00000143398" "PIP5K1A" "A8K4Q0; B4DIN0; hsa:8394; Q99754; Q99755; Q99756" "B cell receptor signaling pathway; Regulation of actin cytoskeleton" "PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; Synthesis of PIPs at the plasma membrane" "4" "0" "0.959" "1.062" "0.994" "1.045" "0.924" "1.027" "0.942" "0.952" "0.855" "105.3" "101.0" "111.8" "104.7" "110.1" "97.4" "108.1" "99.2" "100.3" "90.1" "" "" "" "" "" "" "" "" "" "" "94.7" "81.7" "101.1" "102.2" "90.8" "97.4" "81.0" "87.6" "89.7" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3696003956751780460" "False" "High" "IsMasterProtein" "P37235" "Hippocalcin-like protein 1 OS=Homo sapiens OX=9606 GN=HPCAL1 PE=1 SV=3" "0.000" "False" "7.876" "16" "3" "3" "3" "193" "22.3" "5.35" "9.58" "3" "" "other membranes" "other molecular function" "Pf13499" "3241" "ENSG00000115756" "HPCAL1" "hsa:3241; P37235; Q969S5" "" "" "0" "0" "1.017" "1.074" "1.027" "1.134" "1.058" "1.040" "1.176" "1.109" "1.252" "181.4" "184.4" "194.8" "186.2" "205.7" "191.9" "188.6" "213.3" "201.2" "227.1" "" "" "" "" "" "" "" "" "" "" "163.1" "149.2" "176.2" "181.8" "169.7" "191.9" "141.2" "188.4" "180.0" "81.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2428159041387120762" "False" "High" "IsMasterProtein" "Q9Y664" "KICSTOR complex protein kaptin OS=Homo sapiens OX=9606 GN=KPTN PE=1 SV=2" "0.000" "False" "7.870" "6" "2" "2" "2" "436" "48.1" "5.26" "7.28" "2" "cell organization and biogenesis;stress response;other biological processes" "other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "" "11133" "ENSG00000118162" "KPTN" "B3KN86; B4DQ76; hsa:11133; Q96GT1; Q9Y664" "" "Amino acids regulate mTORC1" "1" "0" "0.883" "1.018" "0.984" "1.071" "0.886" "1.284" "1.103" "0.712" "0.818" "37.2" "32.9" "37.9" "36.6" "39.9" "33.0" "47.8" "41.1" "26.5" "30.5" "" "" "" "" "" "" "" "" "" "" "33.5" "26.6" "34.3" "35.8" "32.9" "33.0" "35.8" "36.3" "23.7" "10.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8409014804587651307" "False" "High" "IsMasterProtein" "Q8NDA8" "Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens OX=9606 GN=MROH1 PE=1 SV=3" "0.000" "False" "7.854" "2" "4" "4" "4" "1641" "181.1" "6.89" "10.07" "4" "" "other cell component" "" "Pf02985, Pf21047" "727957" "ENSG00000179832" "MROH1" "C9JWM5; D3DWL5; hsa:727957; Q0P612; Q569G6; Q6NVW4; Q8N230; Q8NAD1; Q8ND95; Q8NDA8; Q96JJ4" "" "" "0" "0" "0.998" "1.172" "0.921" "0.843" "0.912" "1.004" "1.076" "0.828" "0.907" "174.1" "173.7" "204.0" "160.4" "146.8" "158.8" "174.8" "187.3" "144.1" "157.9" "" "" "" "" "" "" "" "" "" "" "156.5" "140.5" "184.5" "156.5" "121.2" "158.8" "130.9" "165.5" "129.0" "56.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6707411672790695973" "False" "High" "IsMasterProtein" "Q9UGH3" "Solute carrier family 23 member 2 OS=Homo sapiens OX=9606 GN=SLC23A2 PE=1 SV=1" "0.000" "False" "7.853" "2" "1" "2" "1" "650" "70.3" "7.68" "6.53" "1" "cell adhesion;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00860" "9962" "ENSG00000089057" "SLC23A2" "B4DJZ1; hsa:9962; Q8WWR4; Q92512; Q96D54; Q9UGH3; Q9UNU1; Q9UP85" "" "Vitamin C (ascorbate) metabolism" "1" "0" "1.008" "0.925" "0.901" "1.001" "1.038" "1.106" "1.016" "0.896" "0.270" "85.0" "85.7" "78.7" "76.6" "85.1" "88.3" "94.0" "86.4" "76.2" "22.9" "" "" "" "" "" "" "" "" "" "" "76.4" "69.3" "71.2" "74.8" "70.2" "88.3" "70.4" "76.3" "68.2" "8.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2108703214608144017" "False" "High" "IsMasterProtein" "Q7Z591" "Microtubule organization protein AKNA OS=Homo sapiens OX=9606 GN=AKNA PE=1 SV=2" "0.000" "False" "7.840" "2" "2" "2" "2" "1439" "155.0" "6.32" "8.92" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf12443" "80709" "ENSG00000106948" "AKNA" "hsa:80709; Q05BK5; Q5T535; Q5T536; Q5T537; Q64FX6; Q64FX7; Q64FX8; Q64FY2; Q6ZMK0; Q6ZNL2; Q6ZTX0; Q7Z591; Q8TET1; Q8TF33; Q96RR9; Q9H7P7" "" "" "0" "0" "1.034" "0.984" "1.087" "1.058" "1.050" "1.146" "1.071" "0.985" "1.111" "116.0" "119.9" "114.2" "126.1" "122.7" "121.9" "133.0" "124.2" "114.2" "128.9" "" "" "" "" "" "" "" "" "" "" "104.3" "97.0" "103.3" "123.1" "101.3" "121.9" "99.6" "109.7" "102.2" "46.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-72385411951020745" "False" "High" "IsMasterProtein" "Q5VUM1" "Succinate dehydrogenase assembly factor 4, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF4 PE=1 SV=1" "0.000" "False" "7.840" "19" "2" "2" "2" "108" "12.2" "9.36" "7.65" "2" "cell organization and biogenesis;other metabolic processes;stress response" "mitochondrion" "enzyme regulator activity" "Pf07896" "135154" "ENSG00000154079" "SDHAF4" "E1P532; hsa:135154; Q5VUM1" "Mitochondrial complex II assembly" "" "1" "0" "0.942" "0.925" "0.925" "0.928" "1.003" "0.865" "1.062" "0.939" "0.724" "232.5" "219.0" "215.1" "214.9" "215.7" "233.1" "201.1" "246.8" "218.4" "168.4" "" "" "" "" "" "" "" "" "" "" "209.0" "177.2" "194.5" "209.8" "178.0" "233.1" "150.5" "218.0" "195.4" "60.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4404494894943398685" "False" "High" "IsMasterProtein" "Q6P5R6" "Ribosomal protein eL22-like OS=Homo sapiens OX=9606 GN=RPL22L1 PE=1 SV=2" "0.000" "False" "7.837" "22" "2" "2" "2" "122" "14.6" "9.38" "8.23" "2" "protein metabolism;other metabolic processes" "translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01776" "200916" "ENSG00000163584" "RPL22L1" "hsa:200916; Q32Q77; Q6P5R6" "" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "13" "0" "1.003" "1.007" "0.919" "0.954" "0.888" "1.074" "0.948" "0.952" "1.082" "152.2" "152.7" "153.3" "139.8" "145.2" "135.1" "163.5" "144.4" "145.0" "164.7" "" "" "" "" "" "" "" "" "" "" "136.9" "123.6" "138.7" "136.5" "119.8" "135.1" "122.5" "127.5" "129.7" "58.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3461094019956647414" "False" "High" "IsMasterProtein" "Q96KQ7" "Histone-lysine N-methyltransferase EHMT2 OS=Homo sapiens OX=9606 GN=EHMT2 PE=1 SV=3" "0.000" "False" "7.822" "2" "3" "3" "2" "1210" "132.3" "5.45" "7.90" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00023, Pf00856, Pf05033, Pf21533" "10919" "ENSG00000204371; ENSG00000206376; ENSG00000227333; ENSG00000232045; ENSG00000236759; ENSG00000238134" "EHMT2" "B0UZY2; hsa:10919; Q14349; Q5JP83; Q5JQ92; Q5JQA1; Q5JQG3; Q6PK06; Q96KQ7; Q96MH5; Q96QD0; Q9UQL8; Q9Y331" "Histone modifications; Ethanol effects on histone modifications; MTHFR deficiency" "Transcriptional Regulation by E2F6; PKMTs methylate histone lysines; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Regulation of TP53 Activity through Methylation; RNA Polymerase I Transcription Initiation; ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7554911446023016001" "False" "High" "IsMasterProtein" "P51668" "Ubiquitin-conjugating enzyme E2 D1 OS=Homo sapiens OX=9606 GN=UBE2D1 PE=1 SV=1" "0.000" "False" "7.819" "20" "2" "3" "1" "147" "16.6" "7.42" "12.71" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "7321" "ENSG00000072401" "UBE2D1" "A6NLF6; A8K786; hsa:7321; P51668" "Proteasome degradation" "Cdc20:Phospho-APC/C mediated degradation of Cyclin A; Separation of Sister Chromatids; Inactivation of APC/C via direct inhibition of the APC/C complex; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); FCERI mediated NF-kB activation; Downstream TCR signaling; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; CLEC7A (Dectin-1) signaling; CDK-mediated phosphorylation and removal of Cdc6; Neddylation; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Peroxisomal protein import; E3 ubiquitin ligases ubiquitinate target proteins; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; IKK complex recruitment mediated by RIP1; Signaling by BMP; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects; Inactivation of CSF3 (G-CSF) signaling; TICAM1, RIP1-mediated IKK complex recruitment; Regulation of TNFR1 signaling; Negative regulators of DDX58/IFIH1 signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity; Ovarian tumor domain proteases" "35" "0" "0.999" "0.996" "1.108" "1.080" "1.046" "1.000" "0.979" "1.036" "1.070" "156.2" "156.1" "155.6" "173.1" "168.7" "163.3" "156.1" "152.9" "161.8" "167.2" "" "" "" "" "" "" "" "" "" "" "140.4" "126.3" "140.7" "168.9" "139.2" "163.3" "116.9" "135.1" "144.7" "59.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7599147423310777868" "False" "High" "IsMasterProtein" "P55199" "RNA polymerase II elongation factor ELL OS=Homo sapiens OX=9606 GN=ELL PE=1 SV=1" "0.000" "False" "7.817" "5" "2" "2" "2" "621" "68.2" "9.33" "8.75" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07303, Pf10390" "8178" "ENSG00000105656" "ELL" "hsa:8178; P55199" "Interactome of polycomb repressive complex 2 (PRC2)" "RNA polymerase II transcribes snRNA genes; Formation of RNA Pol II elongation complex ; Formation of HIV elongation complex in the absence of HIV Tat; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; Transcription-Coupled Nucleotide Excision Repair (TC-NER)" "14" "0" "1.026" "1.130" "1.132" "1.086" "1.204" "0.929" "1.202" "0.925" "2.901" "28.2" "29.0" "31.9" "32.0" "30.7" "34.0" "26.3" "33.9" "26.1" "81.9" "" "" "" "" "" "" "" "" "" "" "25.4" "23.4" "28.9" "31.2" "25.3" "34.0" "19.7" "30.0" "23.4" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8065211085214910630" "False" "High" "IsMasterProtein" "Q96EL3" "Large ribosomal subunit protein mL53 OS=Homo sapiens OX=9606 GN=MRPL53 PE=1 SV=1" "0.000" "False" "7.817" "21" "2" "3" "2" "112" "12.1" "8.76" "11.65" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "" "Pf10780" "116540" "ENSG00000204822" "MRPL53" "hsa:116540; Q96EL3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.901" "0.868" "1.051" "0.922" "1.049" "1.059" "1.064" "0.940" "1.031" "437.8" "394.4" "380.2" "460.2" "403.7" "459.2" "463.9" "465.7" "411.5" "451.2" "" "" "" "" "" "" "" "" "" "" "393.7" "319.1" "343.9" "449.2" "333.1" "459.2" "347.3" "411.3" "368.2" "161.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8651135355279393622" "False" "High" "IsMasterProtein" "Q8N2G8" "GH3 domain-containing protein OS=Homo sapiens OX=9606 GN=GHDC PE=1 SV=2" "0.000" "False" "7.802" "5" "3" "3" "3" "530" "57.5" "7.88" "8.29" "3" "" "non-structural extracellular;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03321" "84514" "ENSG00000167925" "GHDC" "B4DQS4; E9PDB5; hsa:84514; Q8N2G8; Q9BXM6" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3349657221176052038" "False" "High" "IsMasterProtein" "O00750" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta OS=Homo sapiens OX=9606 GN=PIK3C2B PE=1 SV=2" "0.000" "False" "7.799" "2" "2" "2" "2" "1634" "184.7" "7.30" "6.85" "2" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5287" "ENSG00000133056" "PIK3C2B" "hsa:5287; O00750; O95666; Q5SW99" "Glioblastoma signaling pathways; S1P receptor signal transduction; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Synthesis of PIPs at the plasma membrane" "8" "0" "1.117" "1.088" "1.200" "0.999" "0.978" "1.217" "1.147" "1.085" "1.313" "51.8" "57.8" "56.3" "62.1" "51.7" "50.6" "63.0" "59.4" "56.1" "68.0" "" "" "" "" "" "" "" "" "" "" "46.5" "46.8" "50.9" "60.7" "42.7" "50.6" "47.2" "52.4" "50.2" "24.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-485685737815851415" "False" "High" "IsMasterProtein" "Q6EMK4" "Vasorin OS=Homo sapiens OX=9606 GN=VASN PE=1 SV=1" "0.000" "False" "7.795" "5" "2" "3" "2" "673" "71.7" "7.39" "13.00" "2" "stress response;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;mitochondrion;other cell component" "other molecular function" "Pf00008, Pf13855" "114990" "ENSG00000168140; ENSG00000274334" "VASN" "hsa:114990; Q6EMK4; Q6UXL4; Q6UXL5; Q96CX1" "" "" "0" "0" "1.036" "0.986" "0.906" "0.986" "0.955" "0.906" "1.003" "1.006" "0.670" "162.9" "168.8" "160.6" "147.6" "160.7" "155.7" "147.5" "163.4" "163.8" "109.1" "" "" "" "" "" "" "" "" "" "" "146.5" "136.6" "145.2" "144.1" "132.6" "155.7" "110.5" "144.3" "146.6" "38.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3330412660782960382" "False" "High" "IsMasterProtein" "Q16594" "Transcription initiation factor TFIID subunit 9 OS=Homo sapiens OX=9606 GN=TAF9 PE=1 SV=1" "0.000" "False" "7.792" "11" "2" "2" "2" "264" "29.0" "8.66" "8.66" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02291" "6880" "ENSG00000273841; ENSG00000276463" "TAF9" "D3DWA3; hsa:6880; Q16594; Q5U0D1; Q9BTS1" "Eukaryotic transcription initiation" "HATs acetylate histones; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "12" "0" "0.928" "0.910" "0.935" "0.994" "0.841" "0.940" "0.828" "0.917" "1.973" "160.7" "149.2" "146.3" "150.3" "159.8" "135.2" "151.1" "133.1" "147.5" "317.2" "" "" "" "" "" "" "" "" "" "" "144.5" "120.7" "132.3" "146.8" "131.8" "135.2" "113.1" "117.6" "132.0" "113.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2393292125676734128" "False" "High" "IsMasterProtein" "Q8IWY9" "Codanin-1 OS=Homo sapiens OX=9606 GN=CDAN1 PE=1 SV=4" "0.000" "False" "7.784" "2" "2" "2" "2" "1227" "134.0" "6.77" "6.86" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15296" "146059" "ENSG00000140326" "CDAN1" "hsa:146059; Q6NYD0; Q7Z7L5; Q8IWY9; Q969N3" "" "" "0" "0" "1.449" "1.272" "1.149" "1.610" "1.407" "1.776" "1.298" "1.412" "1.569" "21.4" "31.0" "27.2" "24.6" "34.4" "30.1" "38.0" "27.8" "30.2" "33.6" "" "" "" "" "" "" "" "" "" "" "19.2" "25.1" "24.6" "24.0" "28.4" "30.1" "28.4" "24.5" "27.0" "12.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4435404438671900713" "False" "High" "IsMasterProtein" "Q96N11" "Integrator complex subunit 15 OS=Homo sapiens OX=9606 GN=INTS15 PE=1 SV=1" "0.000" "False" "7.770" "6" "2" "2" "2" "449" "50.0" "7.69" "7.78" "2" "" "nucleus" "" "Pf14964" "79034" "ENSG00000146576" "INTS15" "Q96N11; Q9BQ43" "" "" "0" "0" "1.174" "1.170" "0.991" "1.349" "1.223" "1.228" "1.078" "1.217" "0.902" "112.4" "131.9" "131.5" "111.3" "151.7" "137.4" "138.0" "121.2" "136.8" "101.4" "" "" "" "" "" "" "" "" "" "" "101.1" "106.8" "119.0" "108.7" "125.2" "137.4" "103.4" "107.0" "122.4" "36.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638301692080516805" "False" "High" "IsMasterProtein" "O95817" "BAG family molecular chaperone regulator 3 OS=Homo sapiens OX=9606 GN=BAG3 PE=1 SV=3" "0.000" "False" "7.751" "3" "2" "3" "2" "575" "61.6" "6.95" "7.38" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00397, Pf02179" "9531" "ENSG00000151929" "BAG3" "A8K5L8; hsa:9531; O95817; Q3B763; Q9NT20; Q9P120" "Cell interactions of the pancreatic cancer microenvironment" "Regulation of HSF1-mediated heat shock response" "2" "0" "0.970" "1.076" "0.952" "0.896" "1.051" "1.095" "0.981" "1.046" "1.064" "101.9" "98.8" "109.6" "97.0" "91.3" "107.1" "111.6" "100.0" "106.5" "108.4" "" "" "" "" "" "" "" "" "" "" "91.6" "79.9" "99.1" "94.6" "75.4" "107.1" "83.5" "88.3" "95.3" "38.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8346227288620115762" "False" "High" "IsMasterProtein" "Q86TN4" "tRNA 2'-phosphotransferase 1 OS=Homo sapiens OX=9606 GN=TRPT1 PE=1 SV=2" "0.000" "False" "7.746" "6" "1" "2" "1" "253" "27.7" "9.98" "6.74" "1" "RNA metabolism OR transcription;other metabolic processes" "" "other molecular function" "Pf01885" "83707" "ENSG00000149743" "TRPT1" "A8MU17; A8MYC9; F5H2B2; hsa:83707; Q86TN4; Q9BSB9" "" "" "0" "0" "1.046" "0.937" "0.953" "1.200" "1.021" "1.099" "1.209" "0.894" "1.000" "46.0" "48.1" "43.1" "43.8" "55.2" "47.0" "50.6" "55.6" "41.1" "46.0" "" "" "" "" "" "" "" "" "" "" "41.4" "38.9" "39.0" "42.8" "45.6" "47.0" "37.9" "49.1" "36.8" "16.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6147929922391527183" "False" "High" "IsMasterProtein" "P49116" "Nuclear receptor subfamily 2 group C member 2 OS=Homo sapiens OX=9606 GN=NR2C2 PE=1 SV=1" "0.000" "False" "7.744" "4" "2" "2" "2" "596" "65.4" "6.28" "7.72" "2" "developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7182" "ENSG00000177463" "NR2C2" "A8K3H5; B6ZGT8; hsa:7182; P49116; P55092" "Androgen receptor signaling pathway; Nuclear receptors; Hypothesized pathways in pathogenesis of cardiovascular disease; Epithelial to mesenchymal transition in colorectal cancer" "Nuclear Receptor transcription pathway" "5" "0" "1.066" "0.973" "0.892" "1.202" "1.068" "1.070" "1.037" "1.050" "1.345" "230.6" "245.9" "224.4" "205.6" "277.1" "246.3" "246.6" "239.1" "242.1" "310.2" "" "" "" "" "" "" "" "" "" "" "207.3" "199.0" "203.0" "200.7" "228.7" "246.3" "184.7" "211.2" "216.6" "110.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-162623303281005711" "False" "High" "IsMasterProtein" "P49917" "DNA ligase 4 OS=Homo sapiens OX=9606 GN=LIG4 PE=1 SV=2" "0.000" "False" "7.740" "4" "4" "5" "4" "911" "103.9" "7.96" "10.95" "4" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00533, Pf01068, Pf04675, Pf04679, Pf11411" "3981" "ENSG00000174405" "LIG4" "hsa:3981; P49917; Q8IY66; Q8TEU5" "Non-homologous end joining; Male infertility; DNA repair pathways, full network" "Nonhomologous End-Joining (NHEJ); 2-LTR circle formation" "5" "0" "1.041" "0.960" "0.969" "1.140" "0.904" "0.961" "1.044" "0.924" "1.377" "127.9" "133.1" "122.8" "123.9" "145.8" "115.6" "122.9" "133.5" "118.1" "176.1" "" "" "" "" "" "" "" "" "" "" "115.0" "107.7" "111.0" "120.9" "120.3" "115.6" "92.0" "118.0" "105.7" "62.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4966290939603233061" "False" "High" "IsMasterProtein" "O00461" "Golgi integral membrane protein 4 OS=Homo sapiens OX=9606 GN=GOLIM4 PE=1 SV=1" "0.000" "False" "7.733" "4" "2" "3" "2" "696" "81.8" "4.77" "10.03" "2" "" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "27333" "ENSG00000173905" "GOLIM4" "hsa:27333; O00461" "" "Intra-Golgi traffic" "1" "0" "0.892" "0.761" "0.856" "0.933" "0.783" "1.001" "0.871" "0.736" "0.294" "69.3" "61.8" "52.8" "59.4" "64.7" "54.3" "69.4" "60.4" "51.0" "20.3" "" "" "" "" "" "" "" "" "" "" "62.3" "50.0" "47.7" "58.0" "53.4" "54.3" "52.0" "53.4" "45.7" "7.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3039666916282587145" "False" "High" "IsMasterProtein" "Q562E7" "WD repeat-containing protein 81 OS=Homo sapiens OX=9606 GN=WDR81 PE=1 SV=2" "0.000" "False" "7.729" "2" "3" "3" "3" "1941" "211.6" "5.58" "5.75" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;mitochondrion;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00400, Pf02138" "124997" "ENSG00000167716; ENSG00000276021" "WDR81" "B3KW16; B3KXU1; B7Z579; E9PHG7; hsa:124997; Q24JP6; Q562E7; Q8N277; Q8N3F3; Q8TEL1" "" "CDC42 GTPase cycle" "1" "0" "0.963" "0.942" "0.863" "0.952" "0.952" "0.983" "0.865" "0.869" "1.376" "155.1" "149.3" "146.1" "133.8" "147.7" "147.6" "152.4" "134.1" "134.8" "213.3" "" "" "" "" "" "" "" "" "" "" "139.4" "120.8" "132.2" "130.6" "121.8" "147.6" "114.1" "118.5" "120.6" "76.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5002411829564885472" "False" "High" "IsMasterProtein" "Q9GZQ8" "Microtubule-associated proteins 1A/1B light chain 3B OS=Homo sapiens OX=9606 GN=MAP1LC3B PE=1 SV=3" "0.000" "False" "7.728" "22" "3" "4" "3" "125" "14.7" "8.94" "14.03" "3" "cell organization and biogenesis;other metabolic processes;stress response" "other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02991" "81631" "ENSG00000140941" "MAP1LC3B" "hsa:81631; Q6NW02; Q9GZQ8" "Ferroptosis; Autophagy; Opioid receptor pathways; Network map of SARS-CoV-2 signaling pathway; Clock-controlled autophagy in bone metabolism; 2q37 copy number variation syndrome; Autophagy in pancreatic ductal adenocarcinoma" "KEAP1-NFE2L2 pathway; Macroautophagy; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex; PINK1-PRKN Mediated Mitophagy; TBC/RABGAPs; Receptor Mediated Mitophagy; Pexophagy; SARS-CoV-2 modulates autophagy" "16" "0" "0.960" "1.058" "0.949" "1.006" "0.991" "0.941" "1.037" "1.047" "0.653" "552.6" "530.3" "585.0" "524.3" "555.7" "547.8" "520.2" "573.3" "578.7" "361.1" "" "" "" "" "" "" "" "" "" "" "496.9" "429.1" "529.1" "511.8" "458.6" "547.8" "389.5" "506.4" "517.8" "128.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7700866187711353791" "False" "High" "IsMasterProtein" "Q9P0R6" "GSK3B-interacting protein OS=Homo sapiens OX=9606 GN=GSKIP PE=1 SV=2" "0.000" "False" "7.718" "8" "1" "2" "1" "139" "15.6" "4.48" "7.51" "1" "signal transduction;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf05303" "51527" "ENSG00000100744" "GSKIP" "B3KSZ0; hsa:51527; Q9BST1; Q9NWK0; Q9P0R6" "" "" "0" "0" "0.899" "0.897" "0.801" "1.002" "0.852" "0.921" "0.860" "1.014" "0.894" "260.6" "234.4" "233.8" "208.9" "261.2" "222.1" "240.1" "224.1" "264.3" "233.1" "" "" "" "" "" "" "" "" "" "" "234.3" "189.7" "211.5" "203.9" "215.5" "222.1" "179.8" "197.9" "236.5" "83.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1367534402013747077" "False" "High" "IsMasterProtein" "O75947" "ATP synthase subunit d, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PD PE=1 SV=3" "0.000" "False" "7.710" "20" "4" "4" "4" "161" "18.5" "5.30" "12.55" "4" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05873" "10476" "ENSG00000167863" "ATP5PD" "B2R5L6; hsa:10476; O75947; Q9H3J4" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Mitochondrial protein degradation; Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "0.945" "1.112" "1.074" "1.040" "1.156" "1.039" "1.048" "1.045" "1.824" "361.9" "342.1" "402.6" "388.5" "376.4" "418.4" "376.1" "379.4" "378.1" "659.9" "" "" "" "" "" "" "" "" "" "" "325.4" "276.8" "364.1" "379.2" "310.6" "418.4" "281.6" "335.1" "338.3" "235.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6190490643753871552" "False" "High" "IsMasterProtein" "Q8WTX7" "Cytosolic arginine sensor for mTORC1 subunit 1 OS=Homo sapiens OX=9606 GN=CASTOR1 PE=1 SV=1" "0.000" "False" "7.710" "9" "2" "2" "2" "329" "36.3" "5.19" "7.14" "2" "stress response;other biological processes" "cytosol" "other molecular function" "Pf13840, Pf18700, Pf21389" "652968" "ENSG00000239282" "CASTOR1" "hsa:652968; O76052; Q8WTX7; Q96ND9; Q9UIE8" "" "Amino acids regulate mTORC1" "1" "0" "1.040" "0.966" "0.873" "1.093" "0.901" "1.007" "0.968" "0.883" "0.804" "176.2" "183.2" "170.2" "153.8" "192.7" "158.8" "177.5" "170.6" "155.6" "141.7" "" "" "" "" "" "" "" "" "" "" "158.5" "148.3" "154.0" "150.1" "159.0" "158.8" "132.9" "150.7" "139.2" "50.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559910864719892942" "False" "High" "IsMasterProtein" "Q9NU19" "TBC1 domain family member 22B OS=Homo sapiens OX=9606 GN=TBC1D22B PE=1 SV=3" "0.000" "False" "7.691" "6" "3" "3" "2" "505" "59.0" "7.39" "9.83" "3" "" "" "enzyme regulator activity;other molecular function" "Pf00566" "55633" "ENSG00000065491" "TBC1D22B" "A8KA28; hsa:55633; Q32MQ8; Q5VUK9; Q6P4C3; Q7Z6P7; Q9BPV6; Q9BUT5; Q9NU19; Q9NXB6" "" "" "0" "0" "0.967" "1.105" "0.978" "1.079" "1.145" "0.999" "1.015" "1.041" "0.951" "102.6" "99.2" "113.4" "100.3" "110.7" "117.5" "102.5" "104.2" "106.8" "97.6" "" "" "" "" "" "" "" "" "" "" "92.2" "80.3" "102.5" "97.9" "91.4" "117.5" "76.7" "92.0" "95.5" "34.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5138409153076525613" "False" "High" "IsMasterProtein" "Q9HBI1" "Beta-parvin OS=Homo sapiens OX=9606 GN=PARVB PE=1 SV=1" "0.000" "False" "7.678" "6" "2" "2" "2" "364" "41.7" "6.73" "8.95" "2" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00307" "29780" "ENSG00000188677" "PARVB" "B0QYM8; B0QYN1; B2R9X6; hsa:29780; Q5TGJ5; Q86X93; Q96PN1; Q9HBI1; Q9NSP7; Q9UGT3; Q9Y368; Q9Y3L6; Q9Y3L7" "Focal adhesion" "Regulation of cytoskeletal remodeling and cell spreading by IPP complex components" "3" "0" "1.109" "1.015" "0.982" "0.992" "1.071" "1.071" "1.006" "0.963" "1.718" "141.3" "156.7" "143.5" "138.9" "140.2" "151.3" "151.4" "142.2" "136.1" "242.9" "" "" "" "" "" "" "" "" "" "" "127.1" "126.8" "129.8" "135.5" "115.7" "151.3" "113.4" "125.6" "121.8" "86.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4004394019571150397" "False" "High" "IsMasterProtein" "P25942" "Tumor necrosis factor receptor superfamily member 5 OS=Homo sapiens OX=9606 GN=CD40 PE=1 SV=1" "0.000" "False" "7.677" "13" "2" "2" "2" "277" "30.6" "5.76" "6.82" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "958" "ENSG00000101017" "CD40" "E1P5S9; hsa:958; P25942; Q53GN5; Q5JY15; Q5U007; Q7M4Q8; Q86YK5; Q9BYU0" "Allograft rejection; Complement system; Vitamin D receptor pathway; Nod-like receptor (NLR) signaling pathway; Non-genomic actions of 1,25 dihydroxyvitamin D3; Platelet-mediated interactions with vascular and circulating cells; Inflammatory response pathway; Genes associated with the development of rheumatoid arthritis; Extrafollicular and follicular B cell activation by SARS-CoV-2; Toll-like receptor signaling pathway" "" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8611870974223822516" "False" "High" "IsMasterProtein" "Q8NHP8" "Putative phospholipase B-like 2 OS=Homo sapiens OX=9606 GN=PLBD2 PE=1 SV=2" "0.000" "False" "7.665" "2" "1" "2" "1" "589" "65.4" "6.80" "7.31" "1" "other metabolic processes" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf04916" "196463" "ENSG00000151176" "PLBD2" "F5H5E2; hsa:196463; Q8NHP8" "" "" "0" "0" "1.026" "1.173" "1.110" "1.315" "1.295" "1.384" "0.826" "1.323" "1.124" "64.6" "66.3" "75.8" "71.8" "85.0" "83.7" "89.5" "53.4" "85.5" "72.7" "" "" "" "" "" "" "" "" "" "" "58.1" "53.6" "68.6" "70.1" "70.2" "83.7" "67.0" "47.2" "76.5" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7796576881168078978" "False" "High" "IsMasterProtein" "Q9P2R6" "Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens OX=9606 GN=RERE PE=1 SV=2" "0.000" "False" "7.665" "2" "3" "3" "3" "1566" "172.3" "7.69" "8.89" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00320, Pf01426, Pf01448, Pf03154" "473" "ENSG00000142599" "RERE" "hsa:473; O43393; O75046; O75359; Q5VXL9; Q6P6B9; Q9P2R6; Q9Y2W4" "" "" "0" "0" "0.988" "0.893" "0.922" "0.931" "1.026" "0.981" "1.053" "0.878" "0.843" "348.8" "344.6" "311.4" "321.5" "324.9" "357.9" "342.3" "367.4" "306.1" "294.1" "" "" "" "" "" "" "" "" "" "" "313.6" "278.8" "281.7" "313.8" "268.1" "357.9" "256.3" "324.5" "273.9" "105.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4936048942270731480" "False" "High" "IsMasterProtein" "O00567" "Nucleolar protein 56 OS=Homo sapiens OX=9606 GN=NOP56 PE=1 SV=4" "0.000" "False" "7.648" "5" "2" "3" "2" "594" "66.0" "9.19" "14.81" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01798, Pf08156" "10528" "ENSG00000101361" "NOP56" "hsa:10528; O00567; Q2M3T6; Q9NQ05" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "1.060" "1.044" "0.903" "0.974" "1.198" "1.169" "0.913" "0.978" "0.916" "212.9" "225.6" "222.2" "192.3" "207.3" "255.0" "248.7" "194.4" "208.2" "194.9" "" "" "" "" "" "" "" "" "" "" "191.4" "182.5" "201.0" "187.7" "171.1" "255.0" "186.2" "171.7" "186.3" "69.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9115866675213369101" "False" "High" "IsMasterProtein" "Q99807" "5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ7 PE=1 SV=3" "0.000" "False" "7.642" "13" "3" "3" "3" "217" "24.3" "8.59" "8.28" "3" "other metabolic processes;other biological processes" "other membranes;mitochondrion;nucleus;other cell component" "other molecular function" "Pf03232" "10229" "ENSG00000167186" "COQ7" "B2RDA9; hsa:10229; Q99807; Q9BTT7; Q9H0T5; Q9UEW5; Q9UNR5" "" "Ubiquinol biosynthesis" "1" "0" "0.990" "0.920" "0.959" "0.976" "0.981" "1.076" "1.079" "0.973" "1.044" "160.1" "158.4" "147.3" "153.5" "156.2" "157.1" "172.2" "172.8" "155.7" "167.1" "" "" "" "" "" "" "" "" "" "" "143.9" "128.2" "133.3" "149.8" "128.9" "157.1" "128.9" "152.6" "139.3" "59.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6342560622817440014" "False" "High" "IsMasterProtein" "Q96PU8" "KH domain-containing RNA-binding protein QKI OS=Homo sapiens OX=9606 GN=QKI PE=1 SV=1" "0.000" "False" "7.636" "7" "2" "2" "2" "341" "37.6" "8.56" "7.93" "2" "RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf16544, Pf16551" "9444" "ENSG00000112531" "QKI" "hsa:9444; Q2I375; Q5MJQ1; Q969L9; Q96EJ3; Q96KA3; Q96PU6; Q96PU7; Q96PU8; Q9P0X6; Q9P0X7; Q9P0X8; Q9P0X9; Q9P0Y0; Q9P0Y1" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "Signaling by BRAF and RAF1 fusions" "3" "0" "1.032" "1.063" "0.907" "0.941" "0.982" "1.058" "1.021" "0.949" "1.166" "126.8" "130.9" "134.8" "115.1" "119.3" "124.5" "134.2" "129.4" "120.4" "147.8" "" "" "" "" "" "" "" "" "" "" "114.0" "105.9" "121.9" "112.3" "98.5" "124.5" "100.5" "114.3" "107.7" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5517326746891322777" "False" "High" "IsMasterProtein" "Q9H2P0" "Activity-dependent neuroprotector homeobox protein OS=Homo sapiens OX=9606 GN=ADNP PE=1 SV=1" "0.000" "False" "7.634" "4" "3" "3" "3" "1102" "123.5" "7.34" "6.33" "3" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00046, Pf19627" "23394" "ENSG00000101126" "ADNP" "E1P5Y2; hsa:23394; O94881; Q5BKU2; Q9H2P0; Q9UG34" "" "" "0" "0" "1.005" "1.087" "1.058" "1.082" "1.056" "1.058" "1.110" "0.863" "1.854" "58.0" "58.3" "63.1" "61.4" "62.8" "61.3" "61.4" "64.4" "50.1" "107.6" "" "" "" "" "" "" "" "" "" "" "52.2" "47.2" "57.0" "60.0" "51.8" "61.3" "46.0" "56.9" "44.8" "38.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3789588988762427283" "False" "High" "IsMasterProtein" "Q96FH0" "BLOC-1-related complex subunit 8 OS=Homo sapiens OX=9606 GN=BORCS8 PE=1 SV=1" "0.000" "False" "7.630" "24" "2" "2" "2" "119" "13.4" "5.80" "7.78" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10167" "729991" "ENSG00000254901" "BORCS8" "B2RXF9; hsa:729991; Q96FH0; Q9BT01" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574893947770882391" "False" "High" "IsMasterProtein" "P53701" "Holocytochrome c-type synthase OS=Homo sapiens OX=9606 GN=HCCS PE=1 SV=1" "0.000" "False" "7.612" "9" "2" "2" "2" "268" "30.6" "6.68" "7.96" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "other molecular function" "Pf01265" "3052" "ENSG00000004961" "HCCS" "B3KUS1; hsa:3052; P53701; Q502X8" "" "" "0" "0" "1.041" "0.973" "1.047" "1.116" "1.041" "1.217" "1.196" "0.974" "0.910" "114.3" "119.0" "111.3" "119.6" "127.5" "118.9" "139.1" "136.7" "111.3" "104.0" "" "" "" "" "" "" "" "" "" "" "102.8" "96.3" "100.6" "116.8" "105.2" "118.9" "104.1" "120.7" "99.6" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5611096213630678464" "False" "High" "IsMasterProtein" "P11279" "Lysosome-associated membrane glycoprotein 1 OS=Homo sapiens OX=9606 GN=LAMP1 PE=1 SV=3" "0.000" "False" "7.610" "5" "2" "2" "2" "417" "44.9" "8.75" "9.00" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01299, Pf21222" "3916" "ENSG00000185896" "LAMP1" "B4DWL3; hsa:3916; P11279; Q8WU33; Q96I40; Q9BRD2; Q9NP13" "" "Neutrophil degranulation" "1" "0" "0.881" "0.957" "1.063" "0.902" "1.039" "0.888" "0.942" "0.987" "0.803" "340.3" "299.9" "325.6" "361.7" "307.1" "353.6" "302.2" "320.6" "336.0" "273.3" "" "" "" "" "" "" "" "" "" "" "306.0" "242.7" "294.5" "353.1" "253.4" "353.6" "226.3" "283.2" "300.6" "97.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5420555494446778238" "False" "High" "IsMasterProtein" "P15907" "Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Homo sapiens OX=9606 GN=ST6GAL1 PE=1 SV=1" "0.000" "False" "7.599" "6" "2" "2" "2" "406" "46.6" "9.01" "8.22" "2" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf00777" "6480" "ENSG00000073849" "ST6GAL1" "A8KA14; B2R513; D3DNV3; hsa:6480; P15907" "N-glycan biosynthesis" "Sialic acid metabolism; N-Glycan antennae elongation; Maturation of spike protein; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis" "7" "0" "0.934" "0.933" "0.962" "1.027" "0.987" "0.979" "0.905" "0.864" "0.824" "204.8" "191.2" "191.0" "196.9" "210.2" "202.1" "200.5" "185.2" "176.9" "168.8" "" "" "" "" "" "" "" "" "" "" "184.1" "154.7" "172.8" "192.2" "173.5" "202.1" "150.1" "163.6" "158.2" "60.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2072306986524889695" "False" "High" "IsMasterProtein" "Q8WVD3" "E3 ubiquitin-protein ligase RNF138 OS=Homo sapiens OX=9606 GN=RNF138 PE=1 SV=1" "0.000" "False" "7.583" "8" "2" "2" "2" "245" "28.2" "6.93" "6.48" "2" "cell-cell signaling;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf05605, Pf13923, Pf18574" "51444" "ENSG00000134758" "RNF138" "B2RE17; hsa:51444; Q8WVD3; Q9H8K2; Q9UF87; Q9UKI6" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.944" "1.013" "0.988" "0.944" "1.048" "1.132" "0.842" "1.028" "1.961" "74.5" "70.3" "75.5" "73.6" "70.3" "78.1" "84.3" "62.8" "76.6" "146.1" "" "" "" "" "" "" "" "" "" "" "67.0" "56.9" "68.3" "71.9" "58.0" "78.1" "63.1" "55.4" "68.5" "52.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5451664074513337477" "False" "High" "IsMasterProtein" "O75629" "Protein CREG1 OS=Homo sapiens OX=9606 GN=CREG1 PE=1 SV=1" "0.000" "False" "7.577" "14" "2" "2" "2" "220" "24.1" "7.59" "8.03" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13883" "8804" "ENSG00000143162" "CREG1" "B2RDD4; hsa:8804; O75629; Q8N9A3" "" "Neutrophil degranulation" "1" "0" "1.237" "0.963" "1.167" "1.198" "1.145" "1.115" "1.289" "1.067" "0.907" "55.1" "68.1" "53.0" "64.2" "66.0" "63.1" "61.4" "71.0" "58.7" "50.0" "" "" "" "" "" "" "" "" "" "" "49.5" "55.1" "48.0" "62.7" "54.4" "63.1" "46.0" "62.7" "52.6" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5286637805257654056" "False" "High" "IsMasterProtein" "Q9BQG0" "Myb-binding protein 1A OS=Homo sapiens OX=9606 GN=MYBBP1A PE=1 SV=2" "0.000" "False" "7.568" "2" "3" "3" "3" "1328" "148.8" "9.28" "8.55" "3" "cell organization and biogenesis;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04931" "10514" "ENSG00000132382" "MYBBP1A" "hsa:10514; Q86VM3; Q9BQG0; Q9BW49; Q9P0V5; Q9UF99" "Energy metabolism; 10q11.21q11.23 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression" "3" "0" "0.776" "0.707" "0.910" "0.811" "0.814" "0.854" "0.799" "0.744" "1.952" "63.2" "49.1" "44.6" "57.5" "51.3" "51.5" "54.0" "50.5" "47.0" "123.4" "" "" "" "" "" "" "" "" "" "" "56.8" "39.7" "40.4" "56.2" "42.3" "51.5" "40.4" "44.6" "42.0" "44.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-813312959545056598" "False" "High" "IsMasterProtein" "Q96DT7" "Zinc finger and BTB domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZBTB10 PE=1 SV=2" "0.000" "False" "7.565" "3" "2" "2" "2" "871" "94.8" "5.16" "8.18" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00651" "65986" "ENSG00000205189" "ZBTB10" "A4FVD0; hsa:65986; Q86W96; Q8IXI9; Q96DT7; Q96MH9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8635036141062544876" "False" "High" "IsMasterProtein" "P52655" "Transcription initiation factor IIA subunit 1 OS=Homo sapiens OX=9606 GN=GTF2A1 PE=1 SV=1" "0.000" "False" "7.510" "3" "1" "3" "1" "376" "41.5" "4.55" "8.87" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03153" "2957" "ENSG00000165417" "GTF2A1" "hsa:2957; P52655; Q3KNQ9" "" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Estrogen-dependent gene expression" "10" "0" "0.943" "1.010" "0.933" "1.073" "1.020" "0.978" "1.002" "0.988" "0.803" "183.7" "173.2" "185.6" "171.4" "197.2" "187.4" "179.7" "184.1" "181.5" "147.5" "" "" "" "" "" "" "" "" "" "" "165.2" "140.1" "167.9" "167.4" "162.8" "187.4" "134.6" "162.6" "162.4" "52.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1583521273813264514" "False" "High" "IsMasterProtein" "P35236" "Tyrosine-protein phosphatase non-receptor type 7 OS=Homo sapiens OX=9606 GN=PTPN7 PE=1 SV=3" "0.000" "False" "7.506" "8" "3" "3" "3" "360" "40.5" "6.79" "8.67" "3" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00102" "5778" "ENSG00000143851" "PTPN7" "B3KXE1; hsa:5778; P35236; Q53XK4; Q5SXQ0; Q5SXQ1; Q9BV05" "MAPK signaling pathway; IL-18 signaling pathway" "Interleukin-37 signaling; Negative regulation of MAPK pathway" "4" "0" "0.988" "1.086" "0.963" "0.982" "1.015" "1.111" "0.920" "1.058" "4.818" "135.1" "133.5" "146.7" "130.0" "132.6" "137.1" "150.1" "124.3" "142.9" "650.8" "" "" "" "" "" "" "" "" "" "" "121.5" "108.0" "132.7" "126.9" "109.4" "137.1" "112.4" "109.8" "127.8" "232.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1831448905794715132" "False" "High" "IsMasterProtein" "P84098" "Large ribosomal subunit protein eL19 OS=Homo sapiens OX=9606 GN=RPL19 PE=1 SV=1" "0.000" "False" "7.502" "11" "3" "7" "3" "196" "23.5" "11.47" "13.55" "3" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf01280" "6143" "ENSG00000108298" "RPL19" "B2R4K2; P14118; P22908; P84098; Q502Y6; Q7Z6E4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.021" "1.049" "0.933" "1.003" "1.121" "1.068" "0.999" "1.014" "1.024" "755.5" "771.4" "792.3" "704.5" "757.6" "847.1" "806.6" "754.5" "766.2" "774.0" "" "" "" "" "" "" "" "" "" "" "679.3" "624.2" "716.6" "687.7" "625.2" "847.1" "604.0" "666.4" "685.6" "276.3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "921015601734108377" "False" "High" "IsMasterProtein" "Q6P4Q7" "Metal transporter CNNM4 OS=Homo sapiens OX=9606 GN=CNNM4 PE=1 SV=3" "0.000" "False" "7.502" "4" "2" "2" "2" "775" "86.6" "6.07" "7.19" "2" "transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00571, Pf01595" "26504" "ENSG00000158158" "CNNM4" "B7Z1U0; C7SQM3; C7SQM4; C7SQM5; hsa:26504; Q53RE5; Q6P4Q7; Q9H9G3; Q9HCI0; Q9NRN1" "2q11.2 copy number variation syndrome" "" "1" "0" "0.997" "0.917" "0.943" "0.917" "0.994" "1.071" "0.879" "0.924" "0.912" "102.1" "101.8" "93.6" "96.3" "93.6" "101.4" "109.4" "89.7" "94.3" "93.1" "" "" "" "" "" "" "" "" "" "" "91.8" "82.4" "84.6" "94.0" "77.3" "101.4" "81.9" "79.2" "84.3" "33.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4323681854308555372" "False" "High" "IsMasterProtein" "Q12830" "Nucleosome-remodeling factor subunit BPTF OS=Homo sapiens OX=9606 GN=BPTF PE=1 SV=3" "0.000" "False" "7.496" "1" "3" "3" "2" "3046" "338.1" "6.54" "8.51" "3" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf02791, Pf15613" "2186" "ENSG00000171634" "BPTF" "hsa:2186; Q12830; Q6NX67; Q7Z7D6; Q9UIG2" "Endoderm differentiation; 16p11.2 proximal deletion syndrome" "" "2" "0" "1.056" "0.937" "0.869" "0.894" "0.867" "1.004" "0.918" "0.771" "3.431" "125.7" "132.7" "117.7" "109.2" "112.4" "109.0" "126.2" "115.4" "96.9" "431.3" "" "" "" "" "" "" "" "" "" "" "113.0" "107.4" "106.5" "106.6" "92.7" "109.0" "94.5" "102.0" "86.7" "154.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1162437005396674229" "False" "High" "IsMasterProtein" "Q99442" "Translocation protein SEC62 OS=Homo sapiens OX=9606 GN=SEC62 PE=1 SV=1" "0.000" "False" "7.496" "7" "3" "3" "3" "399" "45.8" "7.12" "9.41" "3" "transport;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03839" "7095" "ENSG00000008952" "SEC62" "D3DNQ0; hsa:7095; O00682; O00729; Q99442" "" "" "0" "0" "1.177" "1.247" "0.942" "1.135" "1.459" "1.344" "1.071" "1.258" "1.134" "68.1" "80.1" "84.9" "64.1" "77.2" "99.3" "91.5" "72.9" "85.6" "77.2" "" "" "" "" "" "" "" "" "" "" "61.2" "64.8" "76.8" "62.6" "63.7" "99.3" "68.5" "64.4" "76.6" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2375435199137725135" "False" "High" "IsMasterProtein" "Q96MH2" "Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1" "0.000" "False" "7.490" "11" "3" "3" "2" "286" "32.4" "6.55" "8.91" "3" "other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf15313" "124790" "ENSG00000168517" "HEXIM2" "D3DX66; hsa:124790; Q96MH2" "" "" "0" "0" "0.908" "0.886" "1.000" "1.107" "0.935" "1.048" "1.033" "1.068" "0.788" "97.3" "88.4" "86.2" "97.3" "107.7" "90.9" "102.0" "100.5" "103.9" "76.7" "" "" "" "" "" "" "" "" "" "" "87.5" "71.5" "78.0" "94.9" "88.9" "90.9" "76.4" "88.8" "93.0" "27.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2761647676892231583" "False" "High" "IsMasterProtein" "P68871" "Hemoglobin subunit beta OS=Homo sapiens OX=9606 GN=HBB PE=1 SV=2" "0.000" "False" "7.484" "17" "2" "2" "1" "147" "16.0" "7.28" "7.89" "2" "other metabolic processes;stress response;transport;other biological processes" "non-structural extracellular;cytosol;other cell component" "other molecular function" "Pf00042" "3043" "ENSG00000244734" "HBB" "A4GX73; B2ZUE0; hsa:3043; P02023; P68871; Q13852; Q14481; Q14510; Q45KT0; Q549N7; Q6FI08; Q6R7N2; Q8IZI1; Q9BX96; Q9UCD6; Q9UCP8; Q9UCP9" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism" "Neutrophil degranulation; Heme signaling; Scavenging of heme from plasma; Late endosomal microautophagy; Cytoprotection by HMOX1; Factors involved in megakaryocyte development and platelet production; Chaperone Mediated Autophagy; Erythrocytes take up carbon dioxide and release oxygen; Erythrocytes take up oxygen and release carbon dioxide" "12" "0" "1.226" "1.173" "1.219" "1.600" "1.239" "1.599" "1.285" "1.537" "2.563" "57.7" "70.7" "67.7" "70.3" "92.3" "71.5" "92.2" "74.1" "88.7" "147.8" "" "" "" "" "" "" "" "" "" "" "51.9" "57.2" "61.2" "68.6" "76.2" "71.5" "69.1" "65.5" "79.3" "52.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5850236467978773586" "False" "High" "IsMasterProtein" "P40692" "DNA mismatch repair protein Mlh1 OS=Homo sapiens OX=9606 GN=MLH1 PE=1 SV=1" "0.000" "False" "7.484" "4" "2" "2" "2" "756" "84.5" "5.72" "7.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01119, Pf13589, Pf16413" "4292" "ENSG00000076242" "MLH1" "B4DI13; B4DQ11; E9PCU2; hsa:4292; P40692" "Ovarian infertility; Chromosomal and microsatellite instability in colorectal cancer ; Male infertility; DNA repair pathways, full network; p53 transcriptional gene network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Meiotic recombination; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "12" "0" "0.970" "1.005" "1.035" "1.039" "0.936" "1.012" "1.037" "0.940" "2.698" "224.2" "217.6" "225.4" "232.0" "233.0" "210.0" "226.9" "232.4" "210.8" "605.0" "" "" "" "" "" "" "" "" "" "" "201.6" "176.0" "203.8" "226.5" "192.2" "210.0" "169.9" "205.3" "188.6" "216.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9180192453950737945" "False" "High" "IsMasterProtein" "A0PJW8" "Death-associated protein-like 1 OS=Homo sapiens OX=9606 GN=DAPL1 PE=1 SV=2" "0.000" "False" "7.479" "24" "3" "3" "3" "107" "11.9" "9.99" "8.62" "3" "stress response;signal transduction;other biological processes" "" "translation activity;other molecular function" "Pf15228" "92196" "ENSG00000163331" "DAPL1" "A0PJW8; A0PJW9; B9EIK6; hsa:92196" "" "" "0" "0" "0.985" "1.104" "1.011" "1.123" "1.147" "1.051" "1.245" "1.223" "1.004" "209.4" "206.3" "231.3" "211.7" "235.2" "240.3" "220.1" "260.8" "256.0" "210.2" "" "" "" "" "" "" "" "" "" "" "188.3" "167.0" "209.2" "206.6" "194.1" "240.3" "164.8" "230.3" "229.1" "75.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8959015413367013633" "False" "High" "IsMasterProtein" "Q6P589" "Tumor necrosis factor alpha-induced protein 8-like protein 2 OS=Homo sapiens OX=9606 GN=TNFAIP8L2 PE=1 SV=1" "0.000" "False" "7.467" "15" "2" "2" "2" "184" "20.5" "8.44" "9.20" "2" "stress response;other biological processes" "nucleus;other cytoplasmic organelle;other cell component" "" "Pf05527" "79626" "ENSG00000163154" "TNFAIP8L2" "hsa:79626; Q6I9Y0; Q6P589; Q9H2H7; Q9H5G2" "" "PI Metabolism" "1" "0" "0.980" "1.049" "0.995" "1.110" "1.041" "1.146" "1.043" "1.049" "1.801" "217.6" "213.4" "228.4" "216.6" "241.5" "226.6" "249.5" "227.0" "228.4" "392.0" "" "" "" "" "" "" "" "" "" "" "195.7" "172.7" "206.6" "211.5" "199.3" "226.6" "186.8" "200.5" "204.4" "139.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8678565654600364554" "False" "High" "IsMasterProtein" "Q8WWV3" "Reticulon-4-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=RTN4IP1 PE=1 SV=2" "0.000" "False" "7.453" "6" "2" "2" "2" "396" "43.6" "9.11" "7.40" "2" "developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf08240, Pf13602" "84816" "ENSG00000130347" "RTN4IP1" "hsa:84816; Q8N9B3; Q8WWV3; Q8WZ66; Q9BRA4" "" "" "0" "0" "1.251" "1.129" "1.044" "1.336" "1.342" "1.070" "1.053" "1.036" "1.405" "67.4" "84.3" "76.1" "70.3" "90.0" "90.4" "72.1" "70.9" "69.8" "94.6" "" "" "" "" "" "" "" "" "" "" "60.6" "68.2" "68.8" "68.6" "74.3" "90.4" "54.0" "62.6" "62.5" "33.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2679816748943853066" "False" "High" "IsMasterProtein" "Q9ULH7" "Myocardin-related transcription factor B OS=Homo sapiens OX=9606 GN=MRTFB PE=1 SV=3" "0.000" "False" "7.444" "2" "2" "2" "1" "1088" "118.1" "6.28" "7.36" "2" "other biological processes" "nucleus" "other molecular function" "Pf02037, Pf02755" "57496" "ENSG00000186260" "MRTFB" "A6ND53; B4DGT8; hsa:57496; Q68CT1; Q6UB16; Q86WW2; Q8N226; Q9ULH7" "" "" "0" "0" "1.043" "1.070" "1.016" "0.964" "1.119" "0.964" "1.099" "1.081" "0.955" "205.2" "214.2" "219.6" "208.6" "197.8" "229.8" "197.9" "225.5" "221.9" "196.0" "" "" "" "" "" "" "" "" "" "" "184.5" "173.3" "198.6" "203.6" "163.3" "229.8" "148.1" "199.2" "198.5" "69.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4548517045609742799" "False" "High" "IsMasterProtein" "Q9NVR5" "Protein kintoun OS=Homo sapiens OX=9606 GN=DNAAF2 PE=1 SV=2" "0.000" "False" "7.436" "5" "3" "3" "3" "837" "91.1" "5.20" "6.24" "3" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;other cell component" "" "Pf08190, Pf18201" "55172" "ENSG00000165506" "DNAAF2" "B9WS54; C0JAP7; hsa:55172; Q86TR1; Q86TY8; Q969Z5; Q9NVR5" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2814878339460431936" "False" "High" "IsMasterProtein" "O43819" "Protein SCO2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=SCO2 PE=1 SV=3" "0.000" "False" "7.403" "7" "2" "2" "2" "266" "29.8" "8.85" "7.59" "2" "cell organization and biogenesis;other metabolic processes;developmental processes;other biological processes" "other membranes;cytoskeleton;mitochondrion" "other molecular function" "Pf02630" "9997" "ENSG00000284194" "SCO2" "hsa:9997; O43819; Q3T1B5; Q9UK87" "p53 transcriptional gene network" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "4" "0" "0.974" "0.903" "0.883" "1.150" "0.981" "1.104" "1.025" "1.011" "1.037" "166.0" "161.6" "149.8" "146.5" "190.8" "162.7" "183.2" "170.1" "167.8" "172.1" "" "" "" "" "" "" "" "" "" "" "149.2" "130.7" "135.5" "143.0" "157.5" "162.7" "137.1" "150.2" "150.1" "61.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952210186294942098" "False" "High" "IsMasterProtein" "O15315" "DNA repair protein RAD51 homolog 2 OS=Homo sapiens OX=9606 GN=RAD51B PE=1 SV=2" "0.000" "False" "7.402" "8" "3" "3" "3" "384" "42.2" "5.69" "8.82" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "5890" "ENSG00000182185" "RAD51B" "hsa:5890; O15315; O60914; O75210; Q3Y4F8; Q6FHX8; Q86SY3; Q86SY4; Q86TR0; Q86U92; Q86U93; Q86U94; Q8N6H4; Q9UPL5" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Factors involved in megakaryocyte development and platelet production; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "10" "0" "1.094" "1.139" "0.907" "1.160" "1.056" "1.091" "1.016" "1.025" "1.095" "259.2" "283.6" "295.3" "235.0" "300.8" "273.8" "282.9" "263.4" "265.6" "283.9" "" "" "" "" "" "" "" "" "" "" "233.0" "229.5" "267.1" "229.4" "248.2" "273.8" "211.8" "232.6" "237.7" "101.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6620394605716673272" "False" "High" "IsMasterProtein" "Q96GX2" "Ataxin-7-like protein 3B OS=Homo sapiens OX=9606 GN=ATXN7L3B PE=1 SV=2" "0.000" "False" "7.398" "10" "1" "2" "1" "97" "10.8" "4.36" "7.40" "1" "other biological processes" "other cell component" "" "" "552889" "ENSG00000253719" "ATXN7L3B" "hsa:552889; Q96GX2" "" "" "0" "0" "0.903" "0.923" "0.951" "0.926" "0.927" "0.964" "0.954" "0.955" "0.899" "417.3" "376.8" "385.1" "396.7" "386.4" "386.7" "402.2" "398.1" "398.4" "374.9" "" "" "" "" "" "" "" "" "" "" "375.2" "304.9" "348.4" "387.3" "318.9" "386.7" "301.2" "351.6" "356.5" "133.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2309309010695254198" "False" "High" "IsMasterProtein" "Q7Z6J8" "E3 ubiquitin-protein ligase E3D OS=Homo sapiens OX=9606 GN=UBE3D PE=1 SV=2" "0.000" "False" "7.388" "7" "2" "2" "2" "389" "43.6" "8.13" "7.29" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09814" "90025" "ENSG00000118420" "UBE3D" "B4DP63; hsa:90025; Q5T4W2; Q6IPR4; Q75UG0; Q7Z6J8; Q9NT42" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.782" "0.955" "0.819" "0.901" "0.945" "0.975" "0.887" "0.914" "1.045" "42.2" "33.0" "40.3" "34.6" "38.0" "39.9" "41.1" "37.4" "38.6" "44.1" "" "" "" "" "" "" "" "" "" "" "38.0" "26.7" "36.5" "33.7" "31.4" "39.9" "30.8" "33.1" "34.5" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3739885640391199971" "False" "High" "IsMasterProtein" "Q8IY57" "YY1-associated factor 2 OS=Homo sapiens OX=9606 GN=YAF2 PE=1 SV=3" "0.000" "False" "7.383" "18" "2" "5" "1" "180" "19.9" "9.72" "9.15" "2" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00641, Pf17219" "10138" "ENSG00000015153" "YAF2" "A8K5P0; B4DFU3; G3V465; hsa:10138; Q8IY57; Q99710" "" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "2753337708247017490" "False" "High" "IsMasterProtein" "Q9H0R6" "Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Homo sapiens OX=9606 GN=QRSL1 PE=1 SV=2" "0.000" "False" "7.370" "7" "3" "3" "3" "528" "57.4" "5.68" "8.43" "3" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01425" "55278" "ENSG00000130348" "QRSL1" "hsa:55278; Q5VWJ4; Q9H0R6; Q9HA60; Q9NV19" "" "" "0" "0" "1.041" "0.995" "0.831" "0.935" "0.938" "1.010" "0.799" "0.988" "1.774" "43.1" "44.9" "42.9" "35.8" "40.3" "40.5" "43.6" "34.5" "42.6" "76.5" "" "" "" "" "" "" "" "" "" "" "38.8" "36.3" "38.8" "35.0" "33.3" "40.5" "32.6" "30.4" "38.1" "27.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8347343991909543181" "False" "High" "IsMasterProtein" "P48200" "Iron-responsive element-binding protein 2 OS=Homo sapiens OX=9606 GN=IREB2 PE=1 SV=4" "0.000" "False" "7.366" "3" "3" "3" "3" "963" "105.0" "7.05" "8.67" "3" "other metabolic processes;transport;developmental processes;other biological processes" "cytosol;mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00330, Pf00694" "3658" "ENSG00000136381" "IREB2" "A0A0A6YY96; A8KAC7; E1CJT9; H0YKU0; hsa:3658; P48200; Q13095; Q1HE21; Q59FQ7; Q8WVK6; Q9UF17" "Iron metabolism in placenta; Ferroptosis" "Iron uptake and transport" "3" "0" "0.957" "1.078" "1.208" "1.095" "0.979" "1.128" "1.054" "1.078" "1.490" "95.3" "91.2" "102.7" "115.1" "104.3" "93.2" "107.4" "100.4" "102.7" "141.9" "" "" "" "" "" "" "" "" "" "" "85.7" "73.8" "92.9" "112.3" "86.1" "93.2" "80.5" "88.7" "91.9" "50.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7002745852381012675" "False" "High" "IsMasterProtein" "P13056" "Nuclear receptor subfamily 2 group C member 1 OS=Homo sapiens OX=9606 GN=NR2C1 PE=1 SV=2" "0.000" "False" "7.341" "5" "2" "2" "2" "603" "67.3" "6.32" "6.26" "2" "signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "7181" "ENSG00000120798" "NR2C1" "A8K5K4; hsa:7181; P13056; Q15625; Q15626" "" "Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors" "2" "0" "1.212" "1.284" "1.180" "1.321" "1.239" "1.216" "1.137" "1.225" "1.511" "29.2" "35.4" "37.5" "34.5" "38.6" "36.2" "35.5" "33.2" "35.8" "44.1" "" "" "" "" "" "" "" "" "" "" "26.2" "28.6" "33.9" "33.6" "31.8" "36.2" "26.6" "29.3" "32.0" "15.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "472644769200762840" "False" "High" "IsMasterProtein" "Q9UJK0" "18S rRNA aminocarboxypropyltransferase OS=Homo sapiens OX=9606 GN=TSR3 PE=1 SV=1" "0.000" "False" "7.329" "9" "2" "3" "2" "312" "33.6" "6.87" "6.77" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol" "other molecular function" "Pf04034, Pf04068" "115939" "ENSG00000007520" "TSR3" "hsa:115939; Q6PJT8; Q9UJK0" "" "rRNA modification in the nucleus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1113653796691851863" "False" "High" "IsMasterProtein" "Q86X83" "COMM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=COMMD2 PE=1 SV=2" "0.000" "False" "7.322" "14" "2" "2" "2" "199" "22.7" "6.73" "7.74" "2" "" "other cell component" "" "Pf07258" "51122" "ENSG00000114744" "COMMD2" "hsa:51122; Q561V4; Q86X83; Q9H3L5; Q9Y5V1" "" "Neddylation" "1" "0" "1.004" "0.938" "0.900" "0.951" "0.950" "1.055" "0.987" "0.957" "1.280" "164.7" "165.4" "154.5" "148.2" "156.6" "156.4" "173.8" "162.5" "157.6" "210.8" "" "" "" "" "" "" "" "" "" "" "148.1" "133.8" "139.7" "144.7" "129.2" "156.4" "130.1" "143.6" "141.0" "75.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2450286954911087625" "False" "High" "IsMasterProtein" "O43325" "LYR motif-containing protein 1 OS=Homo sapiens OX=9606 GN=LYRM1 PE=1 SV=1" "0.000" "False" "7.320" "20" "3" "4" "3" "122" "14.3" "9.94" "12.72" "3" "" "nucleus;other cell component" "" "Pf05347" "57149" "ENSG00000102897" "LYRM1" "B2R4M5; hsa:57149; O43325" "" "" "0" "0" "0.912" "0.938" "0.995" "0.933" "0.922" "0.957" "0.962" "1.015" "0.805" "329.3" "300.4" "309.0" "327.6" "307.4" "303.5" "315.0" "316.8" "334.1" "265.0" "" "" "" "" "" "" "" "" "" "" "296.1" "243.1" "279.5" "319.8" "253.6" "303.5" "235.9" "279.9" "299.0" "94.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8843415988459270294" "False" "High" "IsMasterProtein" "Q7Z2W9" "Large ribosomal subunit protein bL21m OS=Homo sapiens OX=9606 GN=MRPL21 PE=1 SV=2" "0.000" "False" "7.313" "14" "2" "3" "2" "205" "22.8" "9.89" "13.89" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00829" "219927" "ENSG00000197345" "MRPL21" "A6NKU0; C9JPR2; hsa:219927; Q7Z2W9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.981" "1.001" "0.972" "1.020" "0.998" "0.965" "0.999" "1.005" "1.129" "265.4" "260.4" "265.7" "258.0" "270.6" "264.8" "256.1" "265.0" "266.6" "299.7" "" "" "" "" "" "" "" "" "" "" "238.6" "210.7" "240.3" "251.8" "223.3" "264.8" "191.7" "234.1" "238.6" "107.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2288858883428598643" "False" "High" "IsMasterProtein" "P11474" "Steroid hormone receptor ERR1 OS=Homo sapiens OX=9606 GN=ESRRA PE=1 SV=3" "0.000" "False" "7.308" "7" "2" "2" "2" "423" "45.5" "6.38" "6.86" "2" "signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105" "2101" "ENSG00000173153" "ESRRA" "hsa:2101; P11474; Q14514" "Energy metabolism; Nuclear receptors; Pre-implantation embryo; Mitochondrial gene expression" "PPARA activates gene expression; Regulation of RUNX2 expression and activity; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway" "8" "0" "1.186" "1.284" "0.952" "1.246" "1.099" "1.032" "1.195" "1.133" "1.093" "38.8" "46.0" "49.8" "36.9" "48.3" "42.6" "40.0" "46.3" "43.9" "42.4" "" "" "" "" "" "" "" "" "" "" "34.9" "37.2" "45.0" "36.0" "39.9" "42.6" "30.0" "40.9" "39.3" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4321447803487511562" "False" "High" "IsMasterProtein" "Q8NEZ2" "Vacuolar protein sorting-associated protein 37A OS=Homo sapiens OX=9606 GN=VPS37A PE=1 SV=1" "0.000" "False" "7.299" "7" "3" "3" "3" "397" "44.3" "5.57" "7.56" "3" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "" "Pf07200" "137492" "ENSG00000155975" "VPS37A" "hsa:137492; Q336D5; Q6NW27; Q8N3D7; Q8NEZ2; Q8TBL7; Q96DL9" "7q11.23 copy number variation syndrome" "Budding and maturation of HIV virion; Membrane binding and targetting of GAG proteins; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy" "6" "0" "1.063" "0.993" "0.881" "0.943" "1.039" "0.992" "0.997" "0.971" "1.348" "164.5" "174.8" "163.2" "144.9" "155.1" "170.8" "163.2" "163.9" "159.6" "221.7" "" "" "" "" "" "" "" "" "" "" "147.9" "141.4" "147.7" "141.4" "128.0" "170.8" "122.2" "144.8" "142.8" "79.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8242626749563967556" "False" "High" "IsMasterProtein" "Q9Y606" "Pseudouridylate synthase 1 homolog OS=Homo sapiens OX=9606 GN=PUS1 PE=1 SV=3" "0.000" "False" "7.283" "8" "3" "3" "3" "427" "47.4" "8.41" "5.86" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01416" "80324" "ENSG00000177192" "PUS1" "A8K877; B3KQC1; hsa:80324; Q8WYT2; Q9BU44; Q9Y606" "" "" "0" "0" "1.214" "0.919" "0.825" "1.394" "1.286" "1.216" "1.080" "0.985" "6.671" "54.7" "66.4" "50.2" "45.1" "76.2" "70.3" "66.4" "59.0" "53.8" "364.6" "" "" "" "" "" "" "" "" "" "" "49.1" "53.7" "45.4" "44.0" "62.9" "70.3" "49.7" "52.1" "48.2" "130.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8573575756283577734" "False" "High" "IsMasterProtein" "Q8TEH3" "DENN domain-containing protein 1A OS=Homo sapiens OX=9606 GN=DENND1A PE=1 SV=2" "0.000" "False" "7.275" "3" "3" "4" "3" "1009" "110.5" "6.96" "7.99" "3" "transport;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf02141, Pf03455, Pf03456" "57706" "ENSG00000119522" "DENND1A" "A8MZA3; B1AM80; B7Z3C8; B7Z669; D3PFD3; hsa:57706; Q05C88; Q5VWF0; Q6PJZ5; Q8IVD6; Q8TEH3; Q9H796" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "1.024" "1.067" "0.956" "0.997" "1.075" "1.018" "0.886" "1.002" "1.209" "284.2" "290.9" "303.3" "271.6" "283.5" "305.4" "289.3" "251.8" "284.8" "343.6" "" "" "" "" "" "" "" "" "" "" "255.5" "235.4" "274.3" "265.2" "233.9" "305.4" "216.6" "222.4" "254.9" "122.7" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "262985657933925195" "False" "High" "IsMasterProtein" "Q969H6" "Ribonuclease P/MRP protein subunit POP5 OS=Homo sapiens OX=9606 GN=POP5 PE=1 SV=1" "0.000" "False" "7.257" "7" "1" "2" "1" "163" "18.8" "7.27" "6.92" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "51367" "ENSG00000167272" "POP5" "A6NL80; hsa:51367; Q53FS5; Q969H6; Q9Y2Q6" "" "tRNA processing in the nucleus" "1" "0" "1.053" "1.272" "1.096" "1.132" "1.093" "1.111" "1.056" "1.101" "0.881" "60.6" "63.8" "77.1" "66.5" "68.6" "66.3" "67.4" "64.0" "66.7" "53.4" "" "" "" "" "" "" "" "" "" "" "54.5" "51.6" "69.7" "64.9" "56.6" "66.3" "50.5" "56.5" "59.7" "19.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2073188909526316483" "False" "High" "IsMasterProtein" "Q96RJ3" "Tumor necrosis factor receptor superfamily member 13C OS=Homo sapiens OX=9606 GN=TNFRSF13C PE=1 SV=1" "0.000" "False" "7.256" "11" "2" "3" "2" "184" "18.9" "8.21" "12.03" "2" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf09256" "115650" "ENSG00000159958" "TNFRSF13C" "hsa:115650; Q96RJ3" "" "TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "2" "0" "0.901" "1.068" "0.939" "0.934" "1.063" "0.896" "1.031" "1.200" "0.980" "533.7" "481.0" "570.2" "501.4" "498.6" "567.4" "478.1" "550.4" "640.2" "522.9" "" "" "" "" "" "" "" "" "" "" "479.8" "389.2" "515.8" "489.4" "411.4" "567.4" "358.0" "486.2" "572.8" "186.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9086652691068798717" "False" "High" "IsMasterProtein" "P51970" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Homo sapiens OX=9606 GN=NDUFA8 PE=1 SV=3" "0.000" "False" "7.241" "17" "2" "2" "2" "172" "20.1" "7.65" "8.69" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf06747" "4702" "ENSG00000119421" "NDUFA8" "B1AM93; hsa:4702; P51970; Q9Y6N0" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.986" "1.128" "0.999" "0.992" "1.118" "0.996" "1.076" "1.099" "0.981" "254.8" "251.1" "287.3" "254.6" "252.8" "284.8" "253.7" "274.2" "280.0" "249.9" "" "" "" "" "" "" "" "" "" "" "229.1" "203.2" "259.9" "248.5" "208.6" "284.8" "190.0" "242.2" "250.6" "89.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4281551287497306931" "False" "High" "IsMasterProtein" "Q9Y2B9" "cAMP-dependent protein kinase inhibitor gamma OS=Homo sapiens OX=9606 GN=PKIG PE=1 SV=1" "0.000" "False" "7.240" "41" "2" "3" "2" "76" "7.9" "4.25" "4.41" "2" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf02827" "11142" "ENSG00000168734" "PKIG" "hsa:11142; Q9Y2B9" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "" "2" "0" "0.928" "1.019" "0.813" "1.028" "0.905" "1.010" "1.015" "0.937" "0.606" "79.6" "73.9" "81.0" "64.7" "81.8" "72.0" "80.4" "80.8" "74.5" "48.2" "" "" "" "" "" "" "" "" "" "" "71.5" "59.8" "73.3" "63.1" "67.5" "72.0" "60.2" "71.3" "66.7" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9165007621832030545" "False" "High" "IsMasterProtein" "Q7Z624" "Calmodulin-lysine N-methyltransferase OS=Homo sapiens OX=9606 GN=CAMKMT PE=1 SV=2" "0.000" "False" "7.234" "10" "3" "3" "3" "323" "36.1" "6.83" "8.92" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf10294" "79823" "ENSG00000143919" "CAMKMT" "hsa:79823; Q4ZG15; Q53SS6; Q7Z624; Q8N6P5; Q9H5G8" "" "Inactivation, recovery and regulation of the phototransduction cascade; Protein methylation" "2" "0" "0.940" "1.104" "0.885" "0.825" "1.008" "1.025" "0.801" "0.967" "2.797" "121.8" "114.5" "134.4" "107.8" "100.5" "122.8" "124.9" "97.5" "117.8" "340.6" "" "" "" "" "" "" "" "" "" "" "109.5" "92.6" "121.6" "105.2" "82.9" "122.8" "93.5" "86.1" "105.4" "121.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8855314221236891810" "False" "High" "IsMasterProtein" "Q5T0F9" "Coiled-coil and C2 domain-containing protein 1B OS=Homo sapiens OX=9606 GN=CC2D1B PE=1 SV=1" "0.000" "False" "7.232" "3" "3" "3" "2" "858" "94.2" "5.26" "8.65" "3" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00168, Pf21528" "200014" "ENSG00000154222" "CC2D1B" "hsa:200014; Q49AE8; Q5T0F8; Q5T0F9; Q5T0G0; Q6ZNQ1; Q96AP3; Q96I04; Q96JJ1" "" "Sealing of the nuclear envelope (NE) by ESCRT-III" "1" "0" "1.085" "1.136" "0.778" "0.951" "0.980" "1.106" "1.044" "0.958" "1.089" "86.2" "93.4" "97.8" "67.0" "82.0" "84.4" "95.3" "90.0" "82.6" "93.9" "" "" "" "" "" "" "" "" "" "" "77.5" "75.6" "88.5" "65.4" "67.6" "84.4" "71.4" "79.5" "73.9" "33.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7658381107240133843" "False" "High" "IsMasterProtein" "Q5VT06" "Centrosome-associated protein 350 OS=Homo sapiens OX=9606 GN=CEP350 PE=1 SV=1" "0.000" "False" "7.221" "1" "2" "2" "2" "3117" "350.7" "6.33" "5.96" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302, Pf14309" "9857" "ENSG00000135837" "CEP350" "hsa:9857; O75068; Q5VT06; Q8TDK3; Q8WY20" "3q29 copy number variation syndrome" "" "1" "0" "1.133" "1.145" "0.904" "1.314" "1.087" "1.260" "1.244" "1.175" "1.038" "85.9" "97.4" "98.4" "77.7" "112.9" "93.4" "108.2" "106.9" "101.0" "89.2" "" "" "" "" "" "" "" "" "" "" "77.3" "78.8" "89.0" "75.9" "93.2" "93.4" "81.0" "94.4" "90.3" "31.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7079848071820702284" "False" "High" "IsMasterProtein" "Q9BPY3" "Protein FAM118B OS=Homo sapiens OX=9606 GN=FAM118B PE=1 SV=1" "0.000" "False" "7.212" "6" "2" "2" "2" "351" "39.5" "5.99" "7.77" "2" "" "nucleus" "other molecular function" "Pf13289" "79607" "ENSG00000197798" "FAM118B" "hsa:79607; Q9BPY3; Q9H7B0" "" "" "0" "0" "1.005" "1.099" "1.042" "1.080" "1.135" "1.094" "0.926" "1.052" "1.671" "152.9" "153.7" "168.1" "159.3" "165.2" "173.5" "167.4" "141.7" "160.9" "255.5" "" "" "" "" "" "" "" "" "" "" "137.5" "124.4" "152.0" "155.5" "136.3" "173.5" "125.3" "125.1" "144.0" "91.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289103138971436577" "False" "High" "IsMasterProtein" "Q92520" "Protein FAM3C OS=Homo sapiens OX=9606 GN=FAM3C PE=1 SV=1" "0.000" "False" "7.206" "11" "2" "2" "2" "227" "24.7" "8.29" "9.15" "2" "signal transduction" "non-structural extracellular;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf15711" "10447" "ENSG00000196937" "FAM3C" "A6NDN2; A8K3R7; hsa:10447; Q92520" "" "Platelet degranulation" "1" "0" "0.953" "1.222" "0.977" "1.138" "1.042" "1.081" "1.087" "0.941" "1.163" "21.5" "20.5" "26.3" "21.0" "24.5" "22.4" "23.2" "23.4" "20.2" "25.0" "" "" "" "" "" "" "" "" "" "" "19.3" "16.6" "23.8" "20.5" "20.2" "22.4" "17.4" "20.7" "18.1" "8.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6720179589779934486" "False" "High" "IsMasterProtein" "O96007" "Molybdopterin synthase catalytic subunit OS=Homo sapiens OX=9606 GN=MOCS2 PE=1 SV=1" "0.000" "False" "7.193" "10" "2" "2" "2" "188" "20.9" "5.44" "8.44" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02391" "4338" "ENSG00000164172" "MOCS2" "hsa:4338; O96007; Q6IAI3" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "0.943" "1.056" "0.977" "1.053" "1.013" "0.954" "1.041" "1.103" "0.870" "431.0" "406.5" "455.3" "421.1" "453.8" "436.6" "411.1" "448.5" "475.3" "374.8" "" "" "" "" "" "" "" "" "" "" "387.5" "328.9" "411.8" "411.0" "374.5" "436.6" "307.8" "396.1" "425.3" "133.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8790868284272412731" "False" "High" "IsMasterProtein" "Q9UDY8" "Mucosa-associated lymphoid tissue lymphoma translocation protein 1 OS=Homo sapiens OX=9606 GN=MALT1 PE=1 SV=1" "0.000" "False" "7.172" "5" "3" "3" "3" "824" "92.2" "5.73" "7.93" "3" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00656, Pf13895, Pf13927, Pf18703" "10892" "ENSG00000172175" "MALT1" "hsa:10892; Q9NTB7; Q9UDY8; Q9ULX4" "B cell receptor signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; 22q11.2 copy number variation syndrome; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A/inflammasome pathway" "10" "0" "0.962" "1.123" "1.027" "0.969" "0.958" "1.011" "1.068" "1.000" "1.692" "92.7" "89.1" "104.1" "95.1" "89.8" "88.8" "93.7" "98.9" "92.7" "156.8" "" "" "" "" "" "" "" "" "" "" "83.3" "72.1" "94.2" "92.9" "74.1" "88.8" "70.1" "87.4" "82.9" "56.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4531671785395663771" "False" "High" "IsMasterProtein" "Q5SXM8" "DNL-type zinc finger protein OS=Homo sapiens OX=9606 GN=DNLZ PE=1 SV=1" "0.000" "False" "7.163" "13" "2" "2" "2" "178" "19.2" "9.80" "7.68" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf05180" "728489" "ENSG00000213221" "DNLZ" "B2RUX5; B9EJE1; hsa:728489; Q5SXM8" "" "" "0" "0" "0.977" "0.914" "1.068" "1.127" "1.172" "1.203" "1.218" "1.190" "0.964" "35.7" "34.8" "32.6" "38.1" "40.2" "41.8" "42.9" "43.5" "42.5" "34.4" "" "" "" "" "" "" "" "" "" "" "32.1" "28.2" "29.5" "37.2" "33.2" "41.8" "32.1" "38.4" "38.0" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5592449745449549244" "False" "High" "IsMasterProtein" "Q8WUK0" "Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Homo sapiens OX=9606 GN=PTPMT1 PE=1 SV=1" "0.000" "False" "7.158" "10" "2" "2" "2" "201" "22.8" "9.77" "6.36" "2" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00782" "114971" "ENSG00000110536" "PTPMT1" "E9PAT8; hsa:114971; Q7Z557; Q8WUK0; Q96CR2; Q9BXV8" "7q11.23 distal copy number variation" "Synthesis of PG" "2" "0" "1.102" "1.130" "1.150" "1.110" "1.135" "1.105" "1.106" "1.164" "1.214" "200.3" "220.7" "226.3" "230.3" "222.2" "227.3" "221.4" "221.5" "233.2" "243.2" "" "" "" "" "" "" "" "" "" "" "180.1" "178.6" "204.7" "224.8" "183.4" "227.3" "165.8" "195.6" "208.7" "86.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8780259354878837006" "False" "High" "IsMasterProtein" "Q7Z7L7" "Protein zer-1 homolog OS=Homo sapiens OX=9606 GN=ZER1 PE=1 SV=1" "0.000" "False" "7.140" "4" "3" "3" "3" "766" "88.1" "5.62" "9.59" "3" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "" "10444" "ENSG00000160445" "ZER1" "hsa:10444; O00156; Q5T272; Q5T273; Q7Z7L7" "" "" "0" "0" "0.982" "0.998" "0.964" "1.019" "0.974" "0.990" "1.056" "0.951" "0.964" "369.2" "362.7" "368.3" "356.0" "376.1" "359.6" "365.6" "389.8" "351.1" "355.8" "" "" "" "" "" "" "" "" "" "" "331.9" "293.5" "333.1" "347.5" "310.4" "359.6" "273.7" "344.3" "314.1" "127.0" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1829057595259192676" "False" "High" "IsMasterProtein" "Q8ND83" "SLAIN motif-containing protein 1 OS=Homo sapiens OX=9606 GN=SLAIN1 PE=1 SV=3" "0.000" "False" "7.139" "5" "3" "4" "2" "568" "60.6" "7.64" "11.26" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf15301" "122060" "ENSG00000139737" "SLAIN1" "A8K0Z9; B7Z209; hsa:122060; Q5T6P4; Q5T6P7; Q8ND10; Q8ND83; Q96NV0" "" "" "0" "0" "0.965" "0.880" "1.064" "0.934" "1.046" "1.043" "0.778" "1.041" "3.368" "22.2" "21.4" "19.5" "23.6" "20.7" "23.2" "23.1" "17.3" "23.1" "74.7" "" "" "" "" "" "" "" "" "" "" "19.9" "17.3" "17.7" "23.1" "17.1" "23.2" "17.3" "15.2" "20.7" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "934468542703033965" "False" "High" "IsMasterProtein" "Q15477" "Superkiller complex protein 2 OS=Homo sapiens OX=9606 GN=SKIC2 PE=1 SV=3" "0.000" "False" "7.137" "2" "3" "3" "3" "1246" "137.7" "6.06" "7.97" "3" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf08148, Pf13234, Pf17911, Pf21408" "6499" "ENSG00000204351; ENSG00000206353; ENSG00000223493; ENSG00000225737; ENSG00000228896; ENSG00000232616" "SKIC2" "hsa:6499; O15005; Q12902; Q15476; Q15477; Q5ST66" "" "Association of TriC/CCT with target proteins during biosynthesis; mRNA decay by 3' to 5' exoribonuclease" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3216762708121930784" "False" "High" "IsMasterProtein" "Q75N03" "E3 ubiquitin-protein ligase Hakai OS=Homo sapiens OX=9606 GN=CBLL1 PE=1 SV=1" "0.000" "False" "7.123" "5" "2" "3" "2" "491" "54.5" "8.29" "7.41" "2" "cell adhesion;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf18408" "79872" "ENSG00000105879" "CBLL1" "B7ZM03; Q75N03; Q8TAJ4; Q9H5S6" "" "InlA-mediated entry of Listeria monocytogenes into host cells" "1" "0" "0.993" "0.997" "0.958" "0.971" "1.205" "1.045" "0.923" "1.027" "1.029" "97.1" "96.4" "96.8" "93.0" "94.3" "117.0" "101.4" "89.7" "99.7" "99.9" "" "" "" "" "" "" "" "" "" "" "87.3" "78.0" "87.6" "90.8" "77.8" "117.0" "76.0" "79.2" "89.2" "35.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4115267819831113520" "False" "High" "IsMasterProtein" "Q8IX18" "Probable ATP-dependent RNA helicase DHX40 OS=Homo sapiens OX=9606 GN=DHX40 PE=1 SV=2" "0.000" "False" "7.119" "4" "4" "4" "4" "779" "88.5" "8.65" "5.56" "4" "" "" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf04408, Pf07717, Pf21010" "79665" "ENSG00000108406" "DHX40" "B3KTJ5; C9JR60; hsa:79665; Q5JPH4; Q8IX18; Q8TC86; Q8WY53; Q9BXM1; Q9H6M9" "" "" "0" "0" "1.004" "1.111" "0.868" "1.052" "1.027" "0.991" "0.914" "1.033" "1.231" "470.0" "472.1" "522.1" "407.8" "494.5" "482.7" "465.9" "429.4" "485.7" "578.8" "" "" "" "" "" "" "" "" "" "" "422.6" "382.0" "472.2" "398.0" "408.0" "482.7" "348.8" "379.3" "434.6" "206.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3818998789770137613" "False" "High" "IsMasterProtein" "Q9Y4W6" "Mitochondrial inner membrane m-AAA protease component AFG3L2 OS=Homo sapiens OX=9606 GN=AFG3L2 PE=1 SV=2" "0.000" "False" "7.113" "4" "2" "2" "2" "797" "88.5" "8.66" "6.06" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "10939" "ENSG00000141385" "AFG3L2" "hsa:10939; Q6P1L0; Q9Y4W6" "Ciliary landscape; 10q22q23 copy number variation" "Mitochondrial protein degradation; Processing of SMDT1" "4" "0" "1.303" "1.688" "1.438" "1.786" "1.661" "1.545" "1.789" "1.487" "1.890" "9.9" "12.9" "16.7" "14.3" "17.7" "16.5" "15.3" "17.7" "14.7" "18.7" "" "" "" "" "" "" "" "" "" "" "8.9" "10.5" "15.1" "13.9" "14.6" "16.5" "11.5" "15.7" "13.2" "6.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5970229024696725622" "False" "High" "IsMasterProtein" "O96020" "G1/S-specific cyclin-E2 OS=Homo sapiens OX=9606 GN=CCNE2 PE=1 SV=1" "0.000" "False" "7.107" "5" "2" "2" "1" "404" "46.7" "7.83" "6.40" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00134, Pf02984" "9134" "ENSG00000175305" "CCNE2" "hsa:9134; O95439; O96020" "miRNA regulation of DNA damage response; Cell cycle; Parkinson's disease pathway; Retinoblastoma gene in cancer; PI3K-Akt signaling pathway; Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; NF1 copy number variation syndrome ; DNA damage response" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; CDK-mediated phosphorylation and removal of Cdc6; SCF(Skp2)-mediated degradation of p27/p21; Association of TriC/CCT with target proteins during biosynthesis; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); DNA Damage/Telomere Stress Induced Senescence; G0 and Early G1; Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes; p53-Dependent G1 DNA Damage Response" "22" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2849598886551382800" "False" "High" "IsMasterProtein" "Q9P2K5" "Myelin expression factor 2 OS=Homo sapiens OX=9606 GN=MYEF2 PE=1 SV=3" "0.000" "False" "7.095" "3" "2" "2" "2" "600" "64.1" "8.75" "7.28" "2" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf00076" "50804" "ENSG00000104177" "MYEF2" "A7MCZ9; C9J921; C9K0J4; hsa:50804; Q6NUM5; Q7L388; Q7Z4B7; Q9H922; Q9NUQ1; Q9P2K5" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Mitochondrial gene expression" "" "4" "0" "0.909" "1.261" "1.294" "0.924" "1.388" "1.353" "1.109" "1.116" "3.875" "33.8" "30.7" "42.6" "43.7" "31.2" "46.9" "45.7" "37.5" "37.7" "131.0" "" "" "" "" "" "" "" "" "" "" "30.4" "24.9" "38.6" "42.7" "25.8" "46.9" "34.2" "33.1" "33.7" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "776622353869952197" "False" "High" "IsMasterProtein" "O60262" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 OS=Homo sapiens OX=9606 GN=GNG7 PE=1 SV=1" "0.000" "False" "7.090" "44" "2" "3" "2" "68" "7.5" "8.51" "10.70" "2" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2788" "ENSG00000176533" "GNG7" "B2R496; hsa:2788; O60262" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells" "G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; Ca2+ pathway; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "35" "0" "1.036" "0.920" "1.145" "0.986" "1.067" "1.090" "1.009" "1.136" "0.841" "107.8" "111.7" "99.2" "123.4" "106.3" "115.0" "117.5" "108.7" "122.5" "90.6" "" "" "" "" "" "" "" "" "" "" "96.9" "90.4" "89.7" "120.5" "87.7" "115.0" "88.0" "96.0" "109.6" "32.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5639426559288223252" "False" "High" "IsMasterProtein" "Q9UMX5" "Neudesin OS=Homo sapiens OX=9606 GN=NENF PE=1 SV=1" "0.000" "False" "7.078" "12" "2" "2" "2" "172" "18.8" "5.69" "7.63" "2" "signal transduction;other biological processes" "non-structural extracellular;other membranes;mitochondrion;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00173" "29937" "ENSG00000117691" "NENF" "A1KYQ8; hsa:29937; Q53FZ6; Q5TM90; Q9UMX5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-348929784632102448" "False" "High" "IsMasterProtein" "O75306" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS2 PE=1 SV=2" "0.000" "False" "7.077" "6" "2" "2" "2" "463" "52.5" "7.55" "7.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00346" "4720" "ENSG00000158864" "NDUFS2" "D3DVG7; hsa:4720; J3KPM7; O75306; Q5VTW0; Q969P3; Q9UEV3" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "0.975" "0.932" "0.808" "0.928" "0.850" "1.085" "0.909" "0.930" "0.985" "106.8" "104.2" "99.5" "86.3" "99.1" "90.8" "115.8" "97.0" "99.3" "105.2" "" "" "" "" "" "" "" "" "" "" "96.0" "84.3" "90.0" "84.3" "81.8" "90.8" "86.7" "85.7" "88.8" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1703927075416448593" "False" "High" "IsMasterProtein" "P07477" "Serine protease 1 OS=Homo sapiens OX=9606 GN=PRSS1 PE=1 SV=1" "0.000" "False" "7.075" "11" "2" "7" "1" "247" "26.5" "6.51" "22.12" "2" "cell organization and biogenesis;protein metabolism;other biological processes" "non-structural extracellular" "other molecular function" "Pf00089" "5644" "ENSG00000204983; ENSG00000274247" "PRSS1" "A1A509; A6NJ71; B2R5I5; hsa:5644; P07477; Q5NV57; Q7M4N3; Q7M4N4; Q92955; Q9HAN4; Q9HAN5; Q9HAN6; Q9HAN7" "" "Uptake of dietary cobalamins into enterocytes; Activation of Matrix Metalloproteinases" "2" "0" "0.869" "0.858" "0.967" "0.833" "0.755" "0.915" "0.780" "0.792" "0.807" "542.6" "471.5" "465.6" "524.8" "452.2" "409.7" "496.7" "423.4" "429.8" "437.7" "" "" "" "" "" "" "" "" "" "" "487.9" "381.5" "421.1" "512.3" "373.2" "409.7" "371.9" "374.0" "384.6" "156.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1286800557191181783" "False" "High" "IsMasterProtein" "Q14686" "Nuclear receptor coactivator 6 OS=Homo sapiens OX=9606 GN=NCOA6 PE=1 SV=3" "0.000" "False" "7.068" "1" "2" "3" "2" "2063" "219.0" "9.36" "10.67" "2" "RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf13820" "23054" "ENSG00000198646" "NCOA6" "A6NLF1; B2RMN5; E1P5P7; hsa:23054; Q14686; Q9NTZ9; Q9UH74; Q9UK86" "Constitutive androstane receptor pathway; Nuclear receptors meta-pathway; Kleefstra syndrome" "Cytoprotection by HMOX1; Transcriptional regulation of white adipocyte differentiation; PPARA activates gene expression; Formation of WDR5-containing histone-modifying complexes; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Activation of gene expression by SREBF (SREBP); RORA activates gene expression" "15" "0" "1.042" "1.045" "0.966" "0.722" "0.827" "0.923" "0.779" "0.920" "0.783" "49.0" "51.0" "51.2" "47.3" "35.3" "40.5" "45.2" "38.1" "45.0" "38.3" "" "" "" "" "" "" "" "" "" "" "44.0" "41.3" "46.3" "46.2" "29.2" "40.5" "33.9" "33.7" "40.3" "13.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "201437280160465728" "False" "High" "IsMasterProtein" "Q9H9E3" "Conserved oligomeric Golgi complex subunit 4 OS=Homo sapiens OX=9606 GN=COG4 PE=1 SV=3" "0.000" "False" "7.055" "4" "2" "2" "2" "785" "89.0" "5.19" "5.87" "2" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf08318, Pf20662, Pf20663" "25839" "ENSG00000103051" "COG4" "B4DMN8; C9JS23; hsa:25839; Q96D40; Q9BRF0; Q9BVZ2; Q9H5Y4; Q9H9E3; Q9Y3W3" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "0.953" "1.007" "0.970" "0.974" "0.953" "1.180" "0.933" "0.902" "3.967" "44.3" "42.3" "44.7" "43.0" "43.2" "42.3" "52.3" "41.4" "40.0" "175.9" "" "" "" "" "" "" "" "" "" "" "39.9" "34.2" "40.4" "42.0" "35.6" "42.3" "39.2" "36.6" "35.8" "62.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8682712823667695648" "False" "High" "IsMasterProtein" "Q7Z2E3" "Aprataxin OS=Homo sapiens OX=9606 GN=APTX PE=1 SV=2" "0.000" "False" "7.025" "7" "3" "3" "3" "356" "40.7" "9.17" "10.22" "3" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11969, Pf16278, Pf17913" "54840" "ENSG00000137074" "APTX" "A8MTN4; D3DRK9; D3DRL0; hsa:54840; Q0P662; Q5T781; Q5T782; Q5T784; Q6JV81; Q6JV82; Q6JV85; Q7Z2E3; Q7Z2F3; Q7Z336; Q7Z5R5; Q7Z6V7; Q7Z6V8; Q9NXM5" "" "" "0" "0" "0.924" "0.929" "0.914" "0.990" "0.964" "0.855" "0.822" "0.864" "1.368" "300.0" "277.1" "278.6" "274.3" "297.0" "289.2" "256.6" "246.7" "259.3" "410.4" "" "" "" "" "" "" "" "" "" "" "269.7" "224.3" "252.0" "267.7" "245.1" "289.2" "192.1" "217.9" "232.0" "146.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2939061422699868951" "False" "High" "IsMasterProtein" "Q92618" "Zinc finger protein 516 OS=Homo sapiens OX=9606 GN=ZNF516 PE=1 SV=1" "0.000" "False" "7.022" "2" "2" "3" "2" "1163" "124.2" "8.72" "7.49" "2" "stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "9658" "ENSG00000101493" "ZNF516" "hsa:9658; Q92618" "Thermogenesis; Thyroid hormones production and peripheral downstream signaling effects" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4790562829176069588" "False" "High" "IsMasterProtein" "Q9BV19" "Uncharacterized protein C1orf50 OS=Homo sapiens OX=9606 GN=C1orf50 PE=1 SV=2" "0.000" "False" "7.005" "15" "2" "2" "2" "199" "21.9" "5.88" "5.34" "2" "" "" "other molecular function" "Pf10504" "79078" "ENSG00000164008" "C1orf50" "Q9BV19" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8783162572127248995" "False" "High" "IsMasterProtein" "Q9H4A5" "Golgi phosphoprotein 3-like OS=Homo sapiens OX=9606 GN=GOLPH3L PE=1 SV=1" "0.000" "False" "6.987" "8" "2" "2" "2" "285" "32.7" "5.83" "7.36" "2" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf05719" "55204" "ENSG00000143457" "GOLPH3L" "B1AN09; B7Z6N3; hsa:55204; Q9H4A5; Q9NVK0" "" "" "0" "0" "0.880" "0.965" "0.994" "0.839" "0.971" "0.975" "0.915" "0.974" "2.885" "139.7" "122.9" "134.8" "138.8" "117.2" "135.7" "136.3" "127.9" "136.0" "403.2" "" "" "" "" "" "" "" "" "" "" "125.6" "99.5" "121.9" "135.5" "96.7" "135.7" "102.0" "113.0" "121.7" "143.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8896573865465448502" "False" "High" "IsMasterProtein" "Q12815" "Tastin OS=Homo sapiens OX=9606 GN=TROAP PE=1 SV=3" "0.000" "False" "6.986" "3" "3" "3" "3" "778" "83.8" "7.36" "9.64" "3" "cell adhesion" "other cell component" "" "" "10024" "ENSG00000135451" "TROAP" "F8VSF9; hsa:10024; Q12815; Q6PJU7; Q8N5B2" "" "" "0" "0" "1.019" "1.432" "1.040" "1.053" "1.500" "1.138" "1.024" "1.399" "1.680" "172.3" "175.5" "246.8" "179.2" "181.5" "258.4" "196.0" "176.5" "241.1" "289.6" "" "" "" "" "" "" "" "" "" "" "154.9" "142.0" "223.2" "174.9" "149.8" "258.4" "146.8" "155.9" "215.7" "103.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6297313033402222307" "False" "High" "IsMasterProtein" "Q8TF01" "Arginine/serine-rich protein PNISR OS=Homo sapiens OX=9606 GN=PNISR PE=1 SV=2" "0.000" "False" "6.985" "4" "3" "3" "3" "805" "92.5" "10.02" "8.54" "3" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf15996" "25957" "ENSG00000132424" "PNISR" "A8K540; E1P5D2; hsa:25957; Q5T064; Q5T065; Q6P2B4; Q6P2N4; Q6PJ93; Q6PK36; Q7Z640; Q8N2L1; Q8TF00; Q8TF01; Q96K10; Q96SI3; Q96SM5; Q9P076; Q9P0C0; Q9Y4N3" "" "" "0" "0" "0.951" "1.035" "1.202" "0.818" "1.289" "0.970" "1.146" "0.865" "0.728" "55.3" "52.6" "57.3" "66.5" "45.2" "71.3" "53.6" "63.4" "47.8" "40.2" "" "" "" "" "" "" "" "" "" "" "49.7" "42.6" "51.8" "64.9" "37.3" "71.3" "40.2" "56.0" "42.8" "14.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4311553193835580120" "False" "High" "IsMasterProtein" "P56556" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFA6 PE=1 SV=4" "0.000" "False" "6.965" "13" "2" "2" "2" "128" "15.1" "9.98" "6.43" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport" "other membranes;mitochondrion" "transporter activity" "Pf13233" "4700" "ENSG00000184983; ENSG00000272765; ENSG00000273397; ENSG00000277365; ENSG00000281013" "NDUFA6" "B2RE54; hsa:4700; O43675; P56556; Q6FGW0; Q6IBT8; Q6IC39" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "1.112" "1.117" "1.025" "1.163" "1.073" "1.179" "1.227" "1.140" "1.343" "174.1" "193.5" "194.5" "178.5" "202.4" "186.8" "205.3" "213.5" "198.4" "233.9" "" "" "" "" "" "" "" "" "" "" "156.5" "156.6" "175.9" "174.2" "167.0" "186.8" "153.7" "188.6" "177.6" "83.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-386390429922052902" "False" "High" "IsMasterProtein" "Q8TBF2" "Prostamide/prostaglandin F synthase OS=Homo sapiens OX=9606 GN=PRXL2B PE=1 SV=1" "0.000" "False" "6.953" "11" "2" "2" "2" "198" "21.2" "6.67" "8.52" "2" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf13911" "127281" "ENSG00000157870" "PRXL2B" "A8K793; B3KPY3; B4DQR9; B4E0S5; B7ZAC8; B9DI90; B9DI92; J3KQD0; Q8N2H0; Q8TBF2" "Eicosanoid metabolism via cyclooxygenases (COX); Omega-6-fatty acids in senescence" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3705334322242747100" "False" "High" "IsMasterProtein" "Q12788" "Transducin beta-like protein 3 OS=Homo sapiens OX=9606 GN=TBL3 PE=1 SV=2" "0.000" "False" "6.950" "3" "2" "2" "2" "808" "89.0" "6.90" "5.87" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00400, Pf08625" "10607" "ENSG00000183751; ENSG00000291938" "TBL3" "hsa:10607; Q12788; Q59GD6; Q8IVB7; Q96A78" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.877" "0.694" "0.591" "0.727" "1.556" "0.833" "0.636" "0.800" "1.144" "107.3" "94.1" "74.5" "63.5" "78.0" "167.0" "89.5" "68.2" "85.9" "122.8" "" "" "" "" "" "" "" "" "" "" "96.5" "76.2" "67.4" "62.0" "64.4" "167.0" "67.0" "60.3" "76.9" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8604308957137322217" "False" "High" "IsMasterProtein" "Q8IXQ5" "Kelch-like protein 7 OS=Homo sapiens OX=9606 GN=KLHL7 PE=1 SV=2" "0.000" "False" "6.948" "4" "2" "3" "2" "586" "65.9" "6.48" "9.05" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "55975" "ENSG00000122550" "KLHL7" "A4D144; B7Z5I9; G5E9G3; hsa:55975; Q7Z765; Q8IXQ5; Q96MV2; Q9BQF8; Q9UDQ9" "" "" "0" "0" "0.987" "1.002" "0.814" "1.054" "0.923" "0.975" "0.945" "0.955" "0.738" "195.2" "192.8" "195.6" "158.8" "205.7" "180.2" "190.4" "184.4" "186.3" "144.1" "" "" "" "" "" "" "" "" "" "" "175.5" "156.0" "176.9" "155.0" "169.8" "180.2" "142.5" "162.8" "166.7" "51.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "433749903708797592" "False" "High" "IsMasterProtein" "Q8NB46" "Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens OX=9606 GN=ANKRD52 PE=1 SV=3" "0.000" "False" "6.945" "3" "3" "3" "3" "1076" "115.0" "6.48" "4.11" "3" "" "" "" "Pf00023, Pf12796" "283373" "ENSG00000139645" "ANKRD52" "A6NE79; B1Q2K2; hsa:283373; Q8NB46" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-359770206824869393" "False" "High" "IsMasterProtein" "P50747" "Biotin--protein ligase OS=Homo sapiens OX=9606 GN=HLCS PE=1 SV=1" "0.000" "False" "6.942" "4" "3" "4" "3" "726" "80.7" "5.62" "9.60" "3" "protein metabolism;other metabolic processes;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "other molecular function" "Pf02237, Pf03099" "3141" "ENSG00000159267" "HLCS" "B2RAH1; D3DSG6; hsa:3141; P50747; Q99451" "" "Biotin transport and metabolism; Defective HLCS causes multiple carboxylase deficiency" "2" "0" "1.002" "0.962" "0.981" "0.924" "0.908" "0.972" "0.939" "0.985" "0.897" "177.2" "177.5" "170.4" "173.8" "163.6" "160.9" "172.2" "166.4" "174.5" "159.0" "" "" "" "" "" "" "" "" "" "" "159.3" "143.6" "154.1" "169.6" "135.0" "160.9" "128.9" "146.9" "156.1" "56.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1010351863231639578" "False" "High" "IsMasterProtein" "Q8IW41" "MAP kinase-activated protein kinase 5 OS=Homo sapiens OX=9606 GN=MAPKAPK5 PE=1 SV=2" "0.000" "False" "6.940" "5" "2" "2" "1" "473" "54.2" "7.78" "6.75" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8550" "ENSG00000089022" "MAPKAPK5" "B3KVA5; hsa:8550; O60491; Q86X46; Q8IW41; Q9BVX9; Q9UG86" "MAPK signaling pathway; VEGFA-VEGFR2 signaling; p38 MAPK signaling pathway" "Regulation of TP53 Activity through Phosphorylation; Oxidative Stress Induced Senescence; MAPK6/MAPK4 signaling" "6" "0" "1.047" "0.963" "0.917" "1.065" "1.014" "1.027" "1.142" "1.023" "0.990" "93.5" "97.9" "90.0" "85.7" "99.6" "94.8" "96.0" "106.7" "95.6" "92.5" "" "" "" "" "" "" "" "" "" "" "84.0" "79.2" "81.4" "83.7" "82.2" "94.8" "71.9" "94.3" "85.6" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7152432727454643144" "False" "High" "IsMasterProtein" "Q6PII3" "Coiled-coil domain-containing protein 174 OS=Homo sapiens OX=9606 GN=CCDC174 PE=1 SV=3" "0.000" "False" "6.916" "5" "3" "3" "3" "467" "53.9" "6.33" "9.32" "3" "" "nucleus" "" "Pf13300" "51244" "ENSG00000154781" "CCDC174" "hsa:51244; Q6PII3; Q96CS5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3163667791895929702" "False" "High" "IsMasterProtein" "Q63ZY3" "KN motif and ankyrin repeat domain-containing protein 2 OS=Homo sapiens OX=9606 GN=KANK2 PE=1 SV=1" "0.000" "False" "6.900" "3" "3" "3" "3" "851" "91.1" "5.63" "8.38" "3" "cell organization and biogenesis;developmental processes;other biological processes" "mitochondrion;other cell component" "" "Pf12075, Pf12796" "25959" "ENSG00000197256" "KANK2" "B0I1P4; hsa:25959; Q3KQZ3; Q63ZY3; Q6GUF5; Q9H8S4; Q9NUP0; Q9P210" "" "" "0" "0" "1.083" "1.010" "1.059" "1.050" "1.097" "1.120" "0.983" "1.122" "3.567" "91.9" "99.6" "92.9" "97.3" "96.5" "100.8" "103.0" "90.4" "103.2" "328.0" "" "" "" "" "" "" "" "" "" "" "82.7" "80.6" "84.0" "95.0" "79.7" "100.8" "77.1" "79.8" "92.3" "117.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805151388024258847" "False" "High" "IsMasterProtein" "Cont_Q28107" "Coagulation factor V OS=Bos taurus OX=9913 GN=F5 PE=1 SV=1" "0.000" "True" "6.888" "1" "2" "2" "2" "2211" "248.8" "5.83" "7.92" "2" "stress response;other biological processes" "non-structural extracellular;other cell component" "other molecular function" "Pf00754, Pf06049, Pf07732" "280687" "" "F5" "bta:280687; Q28107; Q28108" "" "" "0" "0" "0.884" "0.859" "0.834" "0.888" "0.983" "0.826" "1.007" "0.966" "0.983" "100.9" "89.3" "86.7" "84.2" "89.7" "99.3" "83.4" "101.7" "97.5" "99.2" "" "" "" "" "" "" "" "" "" "" "90.7" "72.2" "78.4" "82.2" "74.0" "99.3" "62.4" "89.8" "87.2" "35.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6814802731580382634" "False" "High" "IsMasterProtein" "Q6SJ96" "TATA box-binding protein-like 2 OS=Homo sapiens OX=9606 GN=TBPL2 PE=2 SV=2" "0.000" "False" "6.887" "7" "3" "3" "3" "343" "38.0" "5.74" "9.14" "3" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00352" "387332" "ENSG00000182521" "TBPL2" "hsa:387332; Q17RU8; Q6SJ96" "" "Germ layer formation at gastrulation" "1" "0" "1.058" "1.061" "0.975" "1.135" "1.110" "1.101" "1.060" "1.109" "1.290" "210.9" "223.0" "223.6" "205.7" "239.2" "234.0" "232.1" "223.4" "233.8" "271.9" "" "" "" "" "" "" "" "" "" "" "189.6" "180.5" "202.3" "200.8" "197.4" "234.0" "173.8" "197.4" "209.2" "97.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681183959761710458" "False" "High" "IsMasterProtein" "Q96G28" "Cilia- and flagella-associated protein 36 OS=Homo sapiens OX=9606 GN=CFAP36 PE=1 SV=2" "0.000" "False" "6.887" "3" "2" "3" "2" "342" "39.4" "4.97" "10.29" "2" "" "cytoskeleton;nucleus;other cell component" "" "Pf11527" "112942" "ENSG00000163001" "CFAP36" "hsa:112942; Q53SF0; Q53ST9; Q6UY34; Q96G28" "" "" "0" "0" "0.981" "1.098" "0.976" "1.064" "1.125" "1.002" "1.093" "1.072" "1.482" "173.0" "169.7" "190.0" "168.7" "184.1" "194.6" "173.4" "189.0" "185.5" "256.3" "" "" "" "" "" "" "" "" "" "" "155.5" "137.3" "171.8" "164.7" "151.9" "194.6" "129.8" "166.9" "166.0" "91.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7399661987366055167" "False" "High" "IsMasterProtein" "O14713" "Integrin beta-1-binding protein 1 OS=Homo sapiens OX=9606 GN=ITGB1BP1 PE=1 SV=1" "0.000" "False" "6.886" "13" "2" "2" "2" "200" "21.8" "6.34" "8.57" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf10480" "9270" "ENSG00000119185" "ITGB1BP1" "D6W4Y9; hsa:9270; O14713; O14714; Q53RS0" "" "" "0" "0" "0.951" "1.100" "0.877" "1.065" "1.050" "0.902" "1.029" "0.951" "0.914" "73.9" "70.3" "81.4" "64.9" "78.7" "77.7" "66.7" "76.1" "70.3" "67.6" "" "" "" "" "" "" "" "" "" "" "66.5" "56.9" "73.6" "63.3" "65.0" "77.7" "49.9" "67.2" "62.9" "24.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6537965283186170392" "False" "High" "IsMasterProtein" "Q9UM13" "Anaphase-promoting complex subunit 10 OS=Homo sapiens OX=9606 GN=ANAPC10 PE=1 SV=1" "0.000" "False" "6.870" "11" "2" "2" "2" "185" "21.2" "9.06" "7.49" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "" "Pf03256" "10393" "ENSG00000164162" "ANAPC10" "D3DNZ7; hsa:10393; Q2V500; Q9UG51; Q9UM13; Q9Y5R0" "Cell cycle" "Separation of Sister Chromatids; Antigen processing: Ubiquitination & Proteasome degradation; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "19" "0" "0.970" "1.179" "1.111" "1.117" "1.074" "1.003" "0.948" "1.075" "0.983" "260.2" "252.5" "306.9" "289.1" "290.7" "279.5" "261.0" "246.8" "279.7" "255.8" "" "" "" "" "" "" "" "" "" "" "234.0" "204.3" "277.6" "282.2" "239.9" "279.5" "195.4" "218.0" "250.3" "91.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5833411024047299895" "False" "High" "IsMasterProtein" "Q02156" "Protein kinase C epsilon type OS=Homo sapiens OX=9606 GN=PRKCE PE=1 SV=1" "0.000" "False" "6.868" "3" "2" "2" "1" "737" "83.6" "7.12" "7.09" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf00130, Pf00168, Pf00433" "5581" "ENSG00000171132" "PRKCE" "B0LPH7; hsa:5581; Q02156; Q32MQ3; Q53SL4; Q53SM5; Q9UE81" "Physiological and pathological hypertrophy of the heart; Oncostatin M signaling pathway; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Wnt signaling pathway and pluripotency; Non-genomic actions of 1,25 dihydroxyvitamin D3; Hippo signaling regulation pathways; Gastrin signaling pathway; Osteoblast differentiation and related diseases; Kisspeptin/kisspeptin receptor system in the ovary; Opioid receptor pathways; Orexin receptor pathway; Chronic hyperglycemia impairment of neuron function; Calcium regulation in cardiac cells; HDAC6 interactions in the central nervous system" "Role of phospholipids in phagocytosis; G alpha (z) signalling events; SHC1 events in ERBB2 signaling; DAG and IP3 signaling; Effects of PIP2 hydrolysis" "21" "0" "1.104" "0.995" "1.525" "1.029" "0.876" "1.150" "1.074" "0.944" "1.031" "83.3" "91.9" "82.9" "127.0" "85.7" "73.0" "95.8" "89.5" "78.6" "85.9" "" "" "" "" "" "" "" "" "" "" "74.9" "74.4" "75.0" "124.0" "70.7" "73.0" "71.7" "79.0" "70.3" "30.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7451398436155471702" "False" "High" "IsMasterProtein" "Q9BRZ2" "E3 ubiquitin-protein ligase TRIM56 OS=Homo sapiens OX=9606 GN=TRIM56 PE=1 SV=3" "0.000" "False" "6.860" "3" "2" "2" "2" "755" "81.4" "7.74" "8.03" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00643, Pf13445" "81844" "ENSG00000169871" "TRIM56" "hsa:81844; Q6PJS5; Q86VT6; Q8N2H8; Q8NAC0; Q9BRZ2; Q9H031" "" "Regulation of innate immune responses to cytosolic DNA" "1" "0" "0.892" "0.828" "0.762" "0.847" "1.021" "0.863" "0.685" "0.795" "0.817" "67.6" "60.3" "55.9" "51.5" "57.2" "69.0" "58.3" "46.3" "53.7" "55.2" "" "" "" "" "" "" "" "" "" "" "60.7" "48.8" "50.6" "50.3" "47.2" "69.0" "43.7" "40.9" "48.1" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7906499553592381403" "False" "High" "IsMasterProtein" "Q7Z5L9" "Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens OX=9606 GN=IRF2BP2 PE=1 SV=2" "0.000" "False" "6.859" "4" "2" "3" "2" "587" "61.0" "8.69" "7.40" "2" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf11261" "359948" "ENSG00000168264" "IRF2BP2" "B1AM35; B1AM36; hsa:359948; Q6P083; Q7Z5L8; Q7Z5L9; Q8N351; Q8WUH8" "" "" "0" "0" "0.922" "0.908" "0.911" "0.931" "1.036" "0.894" "1.011" "0.773" "1.413" "70.4" "64.9" "64.0" "64.1" "65.6" "73.0" "62.9" "71.2" "54.5" "99.5" "" "" "" "" "" "" "" "" "" "" "63.3" "52.5" "57.9" "62.6" "54.1" "73.0" "47.1" "62.9" "48.7" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7691661012823891973" "False" "High" "IsMasterProtein" "P54278" "Mismatch repair endonuclease PMS2 OS=Homo sapiens OX=9606 GN=PMS2 PE=1 SV=2" "0.000" "False" "6.856" "3" "2" "2" "1" "862" "95.7" "6.86" "5.36" "2" "DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01119, Pf08676, Pf13589" "5395" "ENSG00000122512" "PMS2" "B2R610; hsa:5395; P54278; Q52LH6; Q5FBW9; Q5FBX1; Q5FBX2; Q75MR2" "Male infertility; DNA repair pathways, full network; DNA mismatch repair" "TP53 Regulates Transcription of DNA Repair Genes; Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha); Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta); Defective Mismatch Repair Associated With MLH1; Defective Mismatch Repair Associated With PMS2" "8" "0" "0.624" "0.726" "1.053" "0.866" "0.943" "1.447" "0.706" "0.534" "1.838" "16.7" "10.4" "12.1" "17.6" "14.5" "15.8" "24.2" "11.8" "8.9" "30.8" "" "" "" "" "" "" "" "" "" "" "15.0" "8.4" "11.0" "17.2" "12.0" "15.8" "18.1" "10.4" "8.0" "11.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190496341580409730" "False" "High" "IsMasterProtein" "Q5TAX3" "Terminal uridylyltransferase 4 OS=Homo sapiens OX=9606 GN=TUT4 PE=1 SV=3" "0.000" "False" "6.854" "2" "3" "3" "3" "1644" "185.0" "7.97" "6.69" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00098, Pf01909, Pf03828, Pf19088" "23318" "ENSG00000134744" "TUT4" "A2RRP0; B7Z8J5; D3DQ35; hsa:23318; Q12764; Q5TAX2; Q5TAX3; Q5TAX4; Q86XZ3" "" "Zygotic genome activation (ZGA); Deadenylation of mRNA; Z-decay: degradation of maternal mRNAs by zygotically expressed factors" "3" "0" "0.893" "1.284" "1.248" "1.373" "1.309" "1.221" "0.954" "0.983" "1.587" "15.2" "13.6" "19.6" "19.0" "20.9" "20.0" "18.6" "14.5" "15.0" "24.2" "" "" "" "" "" "" "" "" "" "" "13.7" "11.0" "17.7" "18.6" "17.3" "20.0" "13.9" "12.8" "13.4" "8.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1924362681764607279" "False" "High" "IsMasterProtein" "Q8TBF4" "Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Homo sapiens OX=9606 GN=ZCRB1 PE=1 SV=2" "0.000" "False" "6.853" "12" "2" "4" "2" "217" "24.6" "8.53" "12.74" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00076, Pf00098" "85437" "ENSG00000139168" "ZCRB1" "hsa:85437; Q6PJX0; Q8TBF4; Q96TA6" "" "mRNA Splicing - Minor Pathway; Replication of the SARS-CoV-1 genome; Replication of the SARS-CoV-2 genome" "3" "0" "0.963" "0.981" "0.955" "1.014" "1.061" "0.992" "0.993" "1.027" "0.776" "510.1" "491.3" "500.2" "487.0" "517.4" "541.3" "506.2" "506.3" "523.9" "395.8" "" "" "" "" "" "" "" "" "" "" "458.6" "397.6" "452.4" "475.4" "427.0" "541.3" "379.0" "447.2" "468.8" "141.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4839928451091067667" "False" "High" "IsMasterProtein" "Q86SF2" "N-acetylgalactosaminyltransferase 7 OS=Homo sapiens OX=9606 GN=GALNT7 PE=1 SV=1" "0.000" "False" "6.851" "5" "3" "3" "3" "657" "75.3" "7.11" "8.11" "3" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf00535, Pf00652" "51809" "ENSG00000109586" "GALNT7" "B3KQU3; hsa:51809; Q7Z5W7; Q86SF2; Q9UJ28" "" "O-linked glycosylation of mucins" "1" "0" "1.147" "0.920" "0.880" "1.201" "1.143" "1.453" "1.093" "0.959" "0.985" "273.3" "313.3" "251.5" "240.4" "328.1" "312.4" "397.1" "298.6" "262.0" "269.2" "" "" "" "" "" "" "" "" "" "" "245.7" "253.5" "227.5" "234.6" "270.8" "312.4" "297.3" "263.7" "234.5" "96.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2850205802309277585" "False" "High" "IsMasterProtein" "Q96DE0" "U8 snoRNA-decapping enzyme OS=Homo sapiens OX=9606 GN=NUDT16 PE=1 SV=2" "0.000" "False" "6.848" "10" "2" "2" "1" "195" "21.3" "6.89" "7.68" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00293" "131870" "ENSG00000198585" "NUDT16" "B4E3B4; E9PED4; F5GYJ1; hsa:131870; Q96DE0; Q96N82" "" "Phosphate bond hydrolysis by NUDT proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7698628990297234698" "False" "High" "IsMasterProtein" "Q9Y3D3" "Small ribosomal subunit protein bS16m OS=Homo sapiens OX=9606 GN=MRPS16 PE=1 SV=1" "0.000" "False" "6.839" "15" "2" "2" "2" "137" "15.3" "9.50" "6.59" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus" "other molecular function" "Pf00886" "51021" "ENSG00000182180" "MRPS16" "B4E032; hsa:51021; Q96Q60; Q9Y3D3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.092" "0.893" "1.229" "0.885" "0.831" "0.925" "0.901" "0.925" "1.152" "204.8" "223.6" "182.8" "251.7" "181.3" "170.1" "189.4" "184.6" "189.5" "235.9" "" "" "" "" "" "" "" "" "" "" "184.1" "180.9" "165.4" "245.6" "149.6" "170.1" "141.8" "163.1" "169.6" "84.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4257899417113298170" "False" "High" "IsMasterProtein" "P78316" "Nucleolar protein 14 OS=Homo sapiens OX=9606 GN=NOP14 PE=1 SV=3" "0.000" "False" "6.836" "2" "2" "2" "2" "857" "97.6" "7.58" "7.33" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04147" "8602" "ENSG00000087269" "NOP14" "D3DVR6; hsa:8602; P78316; Q7LGI5; Q7Z6K0; Q8TBR6" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.921" "0.922" "0.953" "0.953" "0.966" "1.106" "0.882" "0.924" "1.333" "311.9" "287.4" "287.6" "297.2" "297.3" "301.2" "344.8" "275.0" "288.1" "415.7" "" "" "" "" "" "" "" "" "" "" "280.4" "232.5" "260.1" "290.1" "245.4" "301.2" "258.2" "242.9" "257.8" "148.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-180619704287479053" "False" "High" "IsMasterProtein" "P01137" "Transforming growth factor beta-1 proprotein OS=Homo sapiens OX=9606 GN=TGFB1 PE=1 SV=3" "0.000" "False" "6.822" "8" "2" "2" "2" "390" "44.3" "8.53" "8.71" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00019, Pf00688" "7040" "ENSG00000105329" "TGFB1" "A8K792; hsa:7040; P01137; Q9UCG4" "MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell cycle; Allograft rejection; Interleukin-11 signaling pathway; Corticotropin-releasing hormone signaling pathway; Adipogenesis; Cardiac progenitor differentiation; Spinal cord injury; Primary focal segmental glomerulosclerosis (FSGS); Cardiac hypertrophic response; Mammary gland development pathway - Embryonic development (Stage 1 of 4); Pluripotent stem cell differentiation pathway; Endoderm differentiation; Dopaminergic neurogenesis; IL-3 signaling pathway; Extracellular vesicle-mediated signaling in recipient cells; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Lung fibrosis; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; Interactions between LOXL4 and oxidative stress pathway; MAPK signaling pathway; Canonical and non-canonical TGF-B signaling; Clear cell renal cell carcinoma pathways; Chromosomal and microsatellite instability in colorectal cancer ; Epithelial to mesenchymal transition in colorectal cancer; Type 2 papillary renal cell carcinoma; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Neovascularization processes; Nonalcoholic fatty liver disease; Platelet-mediated interactions with vascular and circulating cells; Control of immune tolerance by vasoactive intestinal peptide; Selective expression of chemokine receptors during T-cell polarization; Signal transduction through IL1R; Envelope proteins and their potential roles in EDMD physiopathology; Interactions between immune cells and microRNAs in tumor microenvironment; Hepatitis B infection; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; Regucalcin in proximal tubule epithelial kidney cells; Overlap between signal transduction pathways contributing to LMNA laminopathies; 3q29 copy number variation syndrome; Angiotensin II receptor type 1 pathway; SARS-CoV-2 innate immunity evasion and cell-specific immune response; T cell modulation in pancreatic cancer; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Complement system in neuronal development and plasticity; Overview of proinflammatory and profibrotic mediators; CCL18 signaling pathway; Progeria-associated lipodystrophy; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Ulcerative colitis signaling; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; Markers of kidney cell lineage; Comprehensive IL-17A signaling; Cell interactions of the pancreatic cancer microenvironment; Immune infiltration in pancreatic cancer; Cytokines and inflammatory response; 1p36 copy number variation syndrome; Macrophage-stimulating protein (MSP) signaling network map; Affected pathways in Duchenne muscular dystrophy; IL-19 signaling pathway; ACE inhibitor pathway; TGF-beta receptor signaling; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "Transcriptional regulation of white adipocyte differentiation; Cell surface interactions at the vascular wall; UCH proteinases; ECM proteoglycans; Platelet degranulation ; Regulation of RUNX3 expression and activity; Interleukin-4 and Interleukin-13 signaling; Syndecan interactions; Downregulation of TGF-beta receptor signaling; Molecules associated with elastic fibres; SMAD2/3 Phosphorylation Motif Mutants in Cancer; TGFBR1 KD Mutants in Cancer; RUNX3 regulates p14-ARF; Influenza Virus Induced Apoptosis; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition); TGFBR2 MSI Frameshift Mutants in Cancer; TGFBR2 Kinase Domain Mutants in Cancer; TGFBR1 LBD Mutants in Cancer; RUNX3 regulates CDKN1A transcription" "95" "0" "0.911" "0.985" "1.044" "0.863" "1.149" "0.932" "1.023" "1.109" "0.677" "89.8" "81.8" "88.4" "93.7" "77.5" "103.1" "83.7" "91.8" "99.6" "60.8" "" "" "" "" "" "" "" "" "" "" "80.7" "66.2" "80.0" "91.5" "64.0" "103.1" "62.7" "81.1" "89.1" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1739336077855480502" "False" "High" "IsMasterProtein" "Q9NWY4" "Histone PARylation factor 1 OS=Homo sapiens OX=9606 GN=HPF1 PE=1 SV=2" "0.000" "False" "6.765" "8" "2" "2" "2" "346" "39.4" "6.80" "3.94" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10228" "54969" "ENSG00000056050" "HPF1" "hsa:54969; Q9NWY4" "" "" "0" "0" "1.041" "1.148" "0.804" "1.073" "0.987" "1.073" "0.948" "1.137" "2.698" "44.9" "46.8" "51.6" "36.1" "48.2" "44.3" "48.2" "42.6" "51.1" "121.2" "" "" "" "" "" "" "" "" "" "" "40.4" "37.8" "46.6" "35.2" "39.8" "44.3" "36.1" "37.6" "45.7" "43.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1753263337049179801" "False" "High" "IsMasterProtein" "O75808" "Calpain-15 OS=Homo sapiens OX=9606 GN=CAPN15 PE=1 SV=1" "0.000" "False" "6.757" "2" "3" "3" "3" "1086" "117.2" "6.71" "6.50" "3" "protein metabolism" "other cell component" "other molecular function" "Pf00641, Pf00648" "6650" "ENSG00000103326" "CAPN15" "B1B1M4; hsa:6650; O75808; Q2KHS2; Q8WTY9; Q9BUW0" "" "Degradation of the extracellular matrix" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6386992515294996358" "False" "High" "IsMasterProtein" "Q8IUZ5" "5-phosphohydroxy-L-lysine phospho-lyase OS=Homo sapiens OX=9606 GN=PHYKPL PE=1 SV=1" "0.000" "False" "6.743" "6" "2" "2" "2" "450" "49.7" "6.76" "7.08" "2" "" "mitochondrion" "other molecular function" "Pf00202" "85007" "ENSG00000175309" "PHYKPL" "A8K7P6; B3KN36; D3DWP9; hsa:85007; Q8IUZ5; Q8WYS6; Q96HW8" "" "Lysine catabolism; Collagen degradation" "2" "0" "1.166" "1.198" "1.105" "1.115" "1.210" "1.262" "1.142" "1.180" "0.958" "89.1" "103.9" "106.7" "98.5" "99.3" "107.9" "112.5" "101.8" "105.2" "85.4" "" "" "" "" "" "" "" "" "" "" "80.1" "84.1" "96.5" "96.1" "82.0" "107.9" "84.2" "89.9" "94.1" "30.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699160270543076643" "False" "High" "IsMasterProtein" "Q14789" "Golgin subfamily B member 1 OS=Homo sapiens OX=9606 GN=GOLGB1 PE=1 SV=2" "0.000" "False" "6.727" "1" "2" "2" "2" "3259" "375.8" "5.00" "6.95" "2" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "nucleic acid binding activity" "" "2804" "ENSG00000173230" "GOLGB1" "B2ZZ91; D3DN92; E7EP74; F1T0J2; hsa:2804; Q14398; Q14789" "" "Golgi Associated Vesicle Biogenesis; COPI-mediated anterograde transport; Signaling by FLT3 fusion proteins" "3" "0" "1.143" "1.078" "1.088" "1.109" "1.094" "1.108" "1.174" "1.117" "1.929" "177.6" "203.1" "191.5" "193.2" "197.0" "194.4" "196.8" "208.5" "198.5" "342.7" "" "" "" "" "" "" "" "" "" "" "159.7" "164.3" "173.2" "188.6" "162.6" "194.4" "147.3" "184.2" "177.6" "122.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5795774045568999421" "False" "High" "IsMasterProtein" "Q9GZR7" "ATP-dependent RNA helicase DDX24 OS=Homo sapiens OX=9606 GN=DDX24 PE=1 SV=1" "0.000" "False" "6.722" "3" "2" "2" "2" "859" "96.3" "9.06" "4.76" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "57062" "ENSG00000089737; ENSG00000273761" "DDX24" "E7EMJ4; hsa:57062; Q4V9L5; Q9GZR7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2494838164348438910" "False" "High" "IsMasterProtein" "Q08117" "TLE family member 5 OS=Homo sapiens OX=9606 GN=TLE5 PE=1 SV=4" "0.000" "False" "6.720" "11" "2" "2" "2" "197" "22.0" "6.37" "7.15" "2" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03920" "166" "ENSG00000104964" "TLE5" "B2RBL0; hsa:166; Q08117; Q12808; Q14CJ1; Q96TG9; Q9UDY9" "Androgen receptor signaling pathway; Ectoderm differentiation" "Repression of WNT target genes" "3" "0" "0.765" "0.675" "1.069" "1.119" "1.084" "1.136" "0.942" "1.105" "0.920" "109.2" "83.5" "73.7" "116.7" "122.2" "118.3" "124.1" "102.8" "120.7" "100.4" "" "" "" "" "" "" "" "" "" "" "98.2" "67.6" "66.6" "113.9" "100.9" "118.3" "92.9" "90.8" "108.0" "35.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3991295495987680044" "False" "High" "IsMasterProtein" "Q15544" "Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1" "0.000" "False" "6.705" "14" "2" "2" "2" "211" "23.3" "4.88" "10.84" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "nucleic acid binding activity;other molecular function" "Pf04719" "6882" "ENSG00000064995" "TAF11" "B2R8R3; B4DY18; hsa:6882; Q15544; Q9UHS0" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "10" "0" "1.027" "1.046" "0.864" "1.063" "1.026" "1.139" "1.006" "0.961" "0.981" "454.6" "467.0" "475.4" "392.9" "483.3" "466.6" "517.6" "457.3" "436.9" "445.9" "" "" "" "" "" "" "" "" "" "" "408.8" "377.9" "430.0" "383.5" "398.8" "466.6" "387.6" "403.9" "390.9" "159.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "516634271704807455" "False" "High" "IsMasterProtein" "Q9BUK0" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 7 OS=Homo sapiens OX=9606 GN=CHCHD7 PE=1 SV=1" "0.000" "False" "6.704" "32" "2" "2" "2" "85" "10.1" "8.82" "8.97" "2" "cell organization and biogenesis" "mitochondrion" "" "Pf02297" "79145" "ENSG00000170791" "CHCHD7" "A8K223; E9PBH3; hsa:79145; J3KNE9; Q7Z588; Q9BUK0" "" "Mitochondrial protein import" "1" "0" "1.054" "0.947" "0.881" "1.135" "1.005" "1.034" "0.997" "0.952" "1.034" "115.2" "121.4" "109.1" "101.5" "130.7" "115.8" "119.1" "114.8" "109.7" "119.1" "" "" "" "" "" "" "" "" "" "" "103.6" "98.2" "98.7" "99.1" "107.9" "115.8" "89.2" "101.4" "98.1" "42.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3425744660855709231" "False" "High" "IsMasterProtein" "O60568" "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 OS=Homo sapiens OX=9606 GN=PLOD3 PE=1 SV=1" "0.000" "False" "6.687" "3" "2" "3" "2" "738" "84.7" "6.05" "9.66" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf03171" "8985" "ENSG00000106397" "PLOD3" "B2R6W6; hsa:8985; O60568; Q540C3" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Collagen biosynthesis and modifying enzymes" "3" "0" "1.212" "1.137" "1.021" "1.078" "1.054" "0.948" "1.085" "1.006" "0.760" "202.1" "244.9" "229.7" "206.3" "217.8" "213.0" "191.7" "219.4" "203.4" "153.7" "" "" "" "" "" "" "" "" "" "" "181.7" "198.1" "207.8" "201.4" "179.8" "213.0" "143.5" "193.7" "182.0" "54.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7919741535000260072" "False" "High" "IsMasterProtein" "Q96K80" "Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens OX=9606 GN=ZC3H10 PE=1 SV=1" "0.000" "False" "6.678" "6" "2" "2" "2" "434" "46.0" "7.64" "7.99" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642, Pf14608" "84872" "ENSG00000135482" "ZC3H10" "hsa:84872; Q96K80" "" "" "0" "0" "0.923" "0.896" "0.952" "0.874" "0.744" "0.932" "0.897" "0.825" "0.722" "297.7" "274.8" "266.7" "283.3" "260.3" "221.4" "277.3" "267.0" "245.5" "215.0" "" "" "" "" "" "" "" "" "" "" "267.6" "222.4" "241.2" "276.6" "214.8" "221.4" "207.7" "235.8" "219.7" "76.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3835661040312072050" "False" "High" "IsMasterProtein" "Q9BUA3" "Spindlin interactor and repressor of chromatin-binding protein OS=Homo sapiens OX=9606 GN=SPINDOC PE=1 SV=3" "0.000" "False" "6.659" "8" "2" "2" "2" "381" "41.0" "5.01" "6.69" "2" "stress response;other biological processes" "nucleus;other cell component" "" "Pf18658" "144097" "ENSG00000168005" "SPINDOC" "hsa:144097; Q68CV7; Q6PHS2; Q96IH0; Q9BUA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7088997935077204775" "False" "High" "IsMasterProtein" "Q03393" "6-pyruvoyl tetrahydrobiopterin synthase OS=Homo sapiens OX=9606 GN=PTS PE=1 SV=1" "0.000" "False" "6.650" "15" "2" "2" "2" "145" "16.4" "6.68" "6.73" "2" "other metabolic processes;developmental processes" "cytosol;mitochondrion;other cell component" "other molecular function" "Pf01242" "5805" "ENSG00000150787" "PTS" "B0YJ87; hsa:5805; Q03393; Q8WVG8" "" "Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation" "1" "0" "1.037" "0.914" "0.999" "1.051" "1.004" "1.036" "1.036" "0.960" "1.353" "225.1" "233.3" "205.8" "224.9" "236.5" "226.1" "233.1" "233.3" "216.2" "304.6" "" "" "" "" "" "" "" "" "" "" "202.4" "188.8" "186.2" "219.5" "195.2" "226.1" "174.6" "206.0" "193.4" "108.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8104731299280243918" "False" "High" "IsMasterProtein" "Q4G148" "Glucoside xylosyltransferase 1 OS=Homo sapiens OX=9606 GN=GXYLT1 PE=1 SV=2" "0.000" "False" "6.647" "5" "2" "2" "2" "440" "50.5" "8.65" "7.98" "2" "protein metabolism;other metabolic processes" "other membranes" "other molecular function" "Pf01501" "283464" "ENSG00000151233" "GXYLT1" "B3KWJ2; hsa:283464; Q4G148; Q8IXV1; Q96BH4" "" "" "0" "0" "1.093" "1.067" "0.987" "1.137" "1.063" "1.071" "1.028" "1.131" "0.921" "257.4" "281.2" "274.5" "253.9" "292.6" "273.7" "275.6" "264.5" "291.2" "236.9" "" "" "" "" "" "" "" "" "" "" "231.4" "227.5" "248.3" "247.9" "241.5" "273.7" "206.3" "233.6" "260.5" "84.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6627210930524934042" "False" "High" "IsMasterProtein" "Q8TCF1" "AN1-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=ZFAND1 PE=1 SV=1" "0.000" "False" "6.643" "15" "2" "2" "2" "268" "30.8" "7.39" "5.21" "2" "cell organization and biogenesis;other biological processes" "other cell component" "other molecular function" "Pf01428" "79752" "ENSG00000104231" "ZFAND1" "E5RIG0; E5RJ99; hsa:79752; Q658R7; Q6IA32; Q6PGQ6; Q8TCF1; Q9H810" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4397574204075436679" "False" "High" "IsMasterProtein" "Q15013" "MAD2L1-binding protein OS=Homo sapiens OX=9606 GN=MAD2L1BP PE=1 SV=1" "0.000" "False" "6.606" "8" "2" "2" "2" "274" "31.0" "6.30" "5.88" "2" "other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06581" "9587" "ENSG00000124688" "MAD2L1BP" "B4DLV3; E9PAT7; hsa:9587; Q15013; Q6IBB1" "3q29 copy number variation syndrome" "" "1" "0" "1.460" "1.479" "1.301" "1.688" "1.396" "1.768" "1.323" "1.549" "1.274" "32.6" "47.6" "48.3" "42.4" "55.1" "45.5" "57.7" "43.2" "50.5" "41.6" "" "" "" "" "" "" "" "" "" "" "29.3" "38.5" "43.6" "41.4" "45.4" "45.5" "43.2" "38.1" "45.2" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6950247271112546932" "False" "High" "IsMasterProtein" "Q9H3N1" "Thioredoxin-related transmembrane protein 1 OS=Homo sapiens OX=9606 GN=TMX1 PE=1 SV=1" "0.000" "False" "6.601" "6" "2" "2" "2" "280" "31.8" "4.98" "6.72" "2" "stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00085" "81542" "ENSG00000139921" "TMX1" "B2R7A4; hsa:81542; Q8N487; Q8NBN5; Q9H3N1; Q9Y4T6" "" "" "0" "0" "0.954" "0.877" "0.942" "0.917" "0.872" "0.901" "0.993" "0.796" "0.532" "369.4" "352.2" "323.9" "348.0" "338.7" "322.0" "332.9" "366.9" "294.0" "196.3" "" "" "" "" "" "" "" "" "" "" "332.1" "285.0" "293.0" "339.7" "279.5" "322.0" "249.3" "324.1" "263.1" "70.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6991992927110115551" "False" "High" "IsMasterProtein" "Q99504" "Eyes absent homolog 3 OS=Homo sapiens OX=9606 GN=EYA3 PE=1 SV=3" "0.000" "False" "6.597" "4" "2" "2" "2" "573" "62.6" "5.21" "6.87" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00702" "2140" "ENSG00000158161" "EYA3" "A8K190; B4DIR7; B4DNZ7; hsa:2140; O95463; Q8IVX7; Q99504; Q99813" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks" "1" "0" "1.062" "0.955" "0.908" "0.975" "0.922" "1.161" "0.719" "1.200" "11.742" "70.6" "74.9" "67.4" "64.0" "68.8" "65.1" "81.9" "50.7" "84.7" "828.5" "" "" "" "" "" "" "" "" "" "" "63.4" "60.6" "61.0" "62.5" "56.8" "65.1" "61.4" "44.8" "75.8" "295.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5981490796003058050" "False" "High" "IsMasterProtein" "Q9H4P4" "E3 ubiquitin-protein ligase NRDP1 OS=Homo sapiens OX=9606 GN=RNF41 PE=1 SV=2" "0.000" "False" "6.589" "9" "2" "2" "2" "317" "35.9" "6.14" "6.30" "2" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08941, Pf13923" "10193" "ENSG00000181852" "RNF41" "A6NFW0; B2RBT8; hsa:10193; O75598; Q9H4P4" "" "Antigen processing: Ubiquitination & Proteasome degradation; Downregulation of ERBB2:ERBB3 signaling" "2" "0" "1.006" "0.887" "0.990" "0.991" "0.892" "0.922" "0.936" "1.094" "1.015" "126.5" "127.2" "112.2" "125.3" "125.4" "112.9" "116.6" "118.4" "138.3" "128.4" "" "" "" "" "" "" "" "" "" "" "113.7" "103.0" "101.5" "122.3" "103.4" "112.9" "87.3" "104.6" "123.8" "45.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2947777995853760023" "False" "High" "IsMasterProtein" "Q53GQ0" "Very-long-chain 3-oxoacyl-CoA reductase OS=Homo sapiens OX=9606 GN=HSD17B12 PE=1 SV=2" "0.000" "False" "6.570" "5" "2" "2" "2" "312" "34.3" "9.32" "7.72" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "extracellular matrix;other membranes;ER/Golgi" "other molecular function" "Pf00106" "51144" "ENSG00000149084" "HSD17B12" "A8K9B0; D3DR23; hsa:51144; Q53GQ0; Q96EA9; Q96JU2; Q9Y6G8" "Mitochondrial fatty acid synthesis pathway" "Synthesis of very long-chain fatty acyl-CoAs; Androgen biosynthesis" "3" "0" "0.931" "1.002" "0.941" "0.948" "0.856" "0.801" "0.931" "1.024" "0.755" "268.9" "250.3" "269.5" "252.9" "255.0" "230.1" "215.3" "250.2" "275.4" "203.1" "" "" "" "" "" "" "" "" "" "" "241.7" "202.5" "243.7" "246.8" "210.4" "230.1" "161.2" "221.0" "246.4" "72.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "877541021914049463" "False" "High" "IsMasterProtein" "Q53S08" "Ras-related protein Rab-6D OS=Homo sapiens OX=9606 GN=RAB6D PE=1 SV=1" "0.000" "False" "6.570" "7" "2" "3" "1" "254" "28.2" "6.74" "10.73" "2" "transport" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "150786" "ENSG00000233087" "RAB6D" "hsa:150786; Q53S08" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5271819707192533656" "False" "High" "IsMasterProtein" "Q9H7E9" "UPF0488 protein C8orf33 OS=Homo sapiens OX=9606 GN=C8orf33 PE=1 SV=1" "0.000" "False" "6.553" "8" "2" "2" "2" "229" "25.0" "9.95" "6.88" "2" "" "" "" "Pf15393" "65265" "ENSG00000182307; ENSG00000291362" "C8orf33" "A6NGC0; hsa:65265; Q96BT8; Q9H7E9" "" "" "0" "0" "0.954" "1.040" "0.877" "0.969" "1.121" "1.076" "0.785" "1.078" "1.252" "265.9" "253.7" "276.6" "233.1" "257.6" "298.1" "286.2" "208.6" "286.7" "333.0" "" "" "" "" "" "" "" "" "" "" "239.1" "205.3" "250.2" "227.6" "212.6" "298.1" "214.3" "184.2" "256.5" "118.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6596351157083836724" "False" "High" "IsMasterProtein" "Q8NC56" "LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=LEMD2 PE=1 SV=1" "0.000" "False" "6.552" "5" "2" "2" "2" "503" "56.9" "9.00" "6.36" "2" "cell organization and biogenesis;developmental processes;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "" "Pf03020, Pf09402" "221496" "ENSG00000161904" "LEMD2" "B4DVH5; E7EVT2; Q5T972; Q5T974; Q8NC56" "" "Sealing of the nuclear envelope (NE) by ESCRT-III; Initiation of Nuclear Envelope (NE) Reformation; Depolymerization of the Nuclear Lamina" "4" "0" "1.354" "1.059" "1.299" "1.249" "1.175" "1.306" "1.273" "1.116" "0.995" "78.4" "106.2" "83.0" "101.9" "98.0" "92.2" "102.5" "99.9" "87.6" "78.0" "" "" "" "" "" "" "" "" "" "" "70.5" "86.0" "75.1" "99.5" "80.9" "92.2" "76.7" "88.2" "78.4" "27.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7952691654267697192" "False" "High" "IsMasterProtein" "Q15067" "Peroxisomal acyl-coenzyme A oxidase 1 OS=Homo sapiens OX=9606 GN=ACOX1 PE=1 SV=3" "0.000" "False" "6.550" "5" "3" "4" "3" "660" "74.4" "8.16" "11.99" "3" "cell organization and biogenesis;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle" "other molecular function" "Pf01756, Pf02770, Pf14749" "51" "ENSG00000161533" "ACOX1" "A8K6X8; A8KAA0; B4DK61; F5GYQ8; hsa:51; Q12863; Q15067; Q15068; Q15101; Q16131; Q7Z3W5; Q9UD31" "Estrogen receptor pathway; Nuclear receptors meta-pathway; PPAR signaling pathway; Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-3 / omega-6 fatty acid synthesis" "TYSND1 cleaves peroxisomal proteins" "8" "0" "1.129" "1.334" "1.006" "1.136" "1.303" "1.124" "1.063" "1.236" "1.045" "507.4" "572.8" "676.6" "510.2" "576.2" "661.3" "570.3" "539.2" "627.1" "530.0" "" "" "" "" "" "" "" "" "" "" "456.2" "463.5" "612.0" "498.0" "475.5" "661.3" "427.0" "476.2" "561.1" "189.2" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7945437556686127836" "False" "High" "IsMasterProtein" "Q96GA3" "Protein LTV1 homolog OS=Homo sapiens OX=9606 GN=LTV1 PE=1 SV=1" "0.000" "False" "6.548" "5" "3" "3" "3" "475" "54.8" "4.91" "9.78" "3" "transport;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04180" "84946" "ENSG00000135521" "LTV1" "hsa:84946; Q96GA3; Q96JX8" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "0.867" "0.837" "0.948" "0.872" "0.900" "0.873" "0.783" "0.854" "0.987" "202.2" "175.3" "169.2" "191.6" "176.4" "181.9" "176.5" "158.4" "172.6" "199.7" "" "" "" "" "" "" "" "" "" "" "181.8" "141.8" "153.0" "187.0" "145.6" "181.9" "132.2" "139.9" "154.5" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9003778122824522310" "False" "High" "IsMasterProtein" "Q9BRT3" "Migration and invasion enhancer 1 OS=Homo sapiens OX=9606 GN=MIEN1 PE=1 SV=1" "0.000" "False" "6.537" "16" "2" "5" "2" "115" "12.4" "4.37" "17.88" "2" "other biological processes" "plasma membrane;other membranes;cytosol" "" "Pf10262" "84299" "ENSG00000141741" "MIEN1" "hsa:84299; Q9BRT3" "17q12 copy number variation syndrome" "" "1" "0" "0.942" "0.911" "0.959" "1.059" "0.908" "1.016" "0.982" "1.028" "0.851" "588.6" "554.5" "536.2" "564.3" "623.0" "534.4" "597.9" "577.9" "605.1" "501.0" "" "" "" "" "" "" "" "" "" "" "529.2" "448.7" "485.0" "550.8" "514.1" "534.4" "447.7" "510.4" "541.4" "178.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7251340200107887376" "False" "High" "IsMasterProtein" "Q6P9B9" "Integrator complex subunit 5 OS=Homo sapiens OX=9606 GN=INTS5 PE=1 SV=1" "0.000" "False" "6.511" "2" "2" "2" "2" "1019" "107.9" "7.05" "7.28" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;nucleus;other cell component" "" "Pf14837, Pf14838" "80789" "ENSG00000185085" "INTS5" "hsa:80789; Q6P9B9; Q8N6W5; Q9C0G5" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "0.964" "0.925" "0.855" "1.018" "1.022" "1.066" "0.919" "0.895" "0.792" "225.1" "216.9" "208.1" "192.4" "229.2" "229.9" "239.9" "206.8" "201.4" "178.3" "" "" "" "" "" "" "" "" "" "" "202.4" "175.5" "188.2" "187.8" "189.1" "229.9" "179.6" "182.7" "180.2" "63.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7568231581715943755" "False" "High" "IsMasterProtein" "Q7Z333" "Probable helicase senataxin OS=Homo sapiens OX=9606 GN=SETX PE=1 SV=4" "0.000" "False" "6.508" "1" "3" "6" "2" "2677" "302.7" "7.17" "15.35" "3" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087" "23064" "ENSG00000107290" "SETX" "A2A396; B2RPB2; B5ME16; C9JQ10; hsa:23064; O75120; Q3KQX4; Q5JUJ1; Q68DW5; Q6AZD7; Q7Z333; Q7Z3J6; Q8WX33; Q9H9D1; Q9NVP9" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.034" "0.988" "0.975" "1.174" "1.095" "1.451" "1.131" "1.032" "2.365" "35.2" "36.4" "34.8" "34.3" "41.3" "38.6" "51.1" "39.8" "36.3" "83.3" "" "" "" "" "" "" "" "" "" "" "31.6" "29.5" "31.5" "33.5" "34.1" "38.6" "38.3" "35.2" "32.5" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6070529034068729651" "False" "High" "IsMasterProtein" "Q8TEV9" "Guanine nucleotide exchange protein SMCR8 OS=Homo sapiens OX=9606 GN=SMCR8 PE=1 SV=2" "0.000" "False" "6.503" "4" "3" "3" "3" "937" "105.0" "5.58" "8.08" "3" "other metabolic processes;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf11704" "140775" "ENSG00000176994; ENSG00000283741" "SMCR8" "A5PKZ5; hsa:140775; Q3ZCN0; Q6PJL3; Q8TEV9" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "1.098" "1.056" "0.953" "1.062" "1.081" "1.143" "1.068" "0.995" "0.812" "82.8" "91.0" "87.5" "78.9" "88.0" "89.6" "94.7" "88.5" "82.4" "67.3" "" "" "" "" "" "" "" "" "" "" "74.5" "73.6" "79.1" "77.1" "72.6" "89.6" "70.9" "78.2" "73.8" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8444785854763805629" "False" "High" "IsMasterProtein" "O15550" "Lysine-specific demethylase 6A OS=Homo sapiens OX=9606 GN=KDM6A PE=1 SV=2" "0.000" "False" "6.501" "2" "2" "2" "2" "1401" "154.1" "7.44" "6.18" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02373, Pf13181, Pf21322, Pf21326" "7403" "ENSG00000147050" "KDM6A" "hsa:7403; O15550; Q52LL9; Q5JVQ7" "Mesodermal commitment pathway; Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma; Pleural mesothelioma; Kleefstra syndrome" "Formation of WDR5-containing histone-modifying complexes; Activation of anterior HOX genes in hindbrain development during early embryogenesis; HDMs demethylate histones; Chromatin modifications during the maternal to zygotic transition (MZT)" "9" "0" "1.066" "1.033" "0.982" "1.046" "0.951" "0.999" "0.896" "1.094" "1.509" "97.9" "104.4" "101.2" "96.1" "102.4" "93.2" "97.8" "87.7" "107.1" "147.7" "" "" "" "" "" "" "" "" "" "" "88.0" "84.5" "91.5" "93.8" "84.5" "93.2" "73.3" "77.5" "95.8" "52.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3120640487531832187" "False" "High" "IsMasterProtein" "Q9BTT4" "Mediator of RNA polymerase II transcription subunit 10 OS=Homo sapiens OX=9606 GN=MED10 PE=1 SV=1" "0.000" "False" "6.494" "10" "1" "4" "1" "135" "15.7" "6.19" "8.47" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09748" "84246" "ENSG00000133398; ENSG00000291745" "MED10" "C6G491; hsa:84246; Q9BTT4" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7820090330366172225" "False" "High" "IsMasterProtein" "Cont_Q7RTS7" "Keratin, type II cytoskeletal 74 OS=Homo sapiens OX=9606 GN=KRT74 PE=1 SV=2" "0.000" "True" "6.473" "5" "3" "3" "1" "529" "57.8" "7.71" "9.57" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "bone, tooth or skin structural activity;other molecular function" "Pf00038, Pf16208" "121391" "ENSG00000170484" "KRT74" "B5MD61; hsa:121391; Q7RTS7; Q86Y45" "" "Formation of the cornified envelope" "2" "0" "1.021" "1.110" "1.709" "1.029" "3.825" "1.846" "1.614" "1.146" "1.540" "85.2" "87.0" "94.6" "145.6" "87.7" "325.9" "157.3" "137.5" "97.7" "131.2" "" "" "" "" "" "" "" "" "" "" "76.6" "70.4" "85.5" "142.2" "72.3" "325.9" "117.8" "121.5" "87.4" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9109513475254745228" "False" "High" "IsMasterProtein" "Q9UBD5" "Origin recognition complex subunit 3 OS=Homo sapiens OX=9606 GN=ORC3 PE=1 SV=1" "0.000" "False" "6.451" "3" "2" "3" "2" "711" "82.2" "7.61" "4.63" "2" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf07034, Pf18137, Pf19675" "23595" "ENSG00000135336" "ORC3" "A2A2T5; B4E025; hsa:23595; Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UBD5; Q9UG44; Q9UNT6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "0.968" "0.818" "0.782" "0.757" "0.828" "1.007" "0.620" "0.705" "1.636" "16.8" "16.3" "13.8" "13.1" "12.7" "13.9" "16.9" "10.4" "11.8" "27.5" "" "" "" "" "" "" "" "" "" "" "15.1" "13.2" "12.4" "12.8" "10.5" "13.9" "12.7" "9.2" "10.6" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4791788072284182717" "False" "High" "IsMasterProtein" "Q96GM5" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 OS=Homo sapiens OX=9606 GN=SMARCD1 PE=1 SV=2" "0.000" "False" "6.449" "5" "2" "2" "2" "515" "58.2" "9.25" "9.09" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02201" "6602" "ENSG00000066117" "SMARCD1" "A6NN27; hsa:6602; Q92924; Q96GM5; Q9Y635" "Androgen receptor network in prostate cancer; Tumor suppressor activity of SMARCB1; Thermogenesis; Kleefstra syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "6" "0" "0.878" "1.457" "1.000" "1.083" "1.014" "1.064" "1.020" "0.975" "2.315" "102.5" "89.9" "149.3" "102.5" "111.0" "103.9" "109.1" "104.5" "99.9" "237.2" "" "" "" "" "" "" "" "" "" "" "92.1" "72.8" "135.0" "100.0" "91.6" "103.9" "81.7" "92.3" "89.4" "84.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5731333323507382333" "False" "High" "IsMasterProtein" "Q8NB78" "Lysine-specific histone demethylase 2 OS=Homo sapiens OX=9606 GN=KDM1B PE=1 SV=3" "0.000" "False" "6.436" "2" "1" "2" "1" "822" "92.0" "7.87" "5.93" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01593, Pf04433, Pf07496" "221656" "ENSG00000165097" "KDM1B" "A2A2C5; A2A2C6; hsa:221656; Q5TGV3; Q6AI15; Q6ZUU4; Q8N258; Q8NB78; Q96EL7" "Vitamin D-sensitive calcium signaling in depression" "UCH proteinases; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "4" "0" "1.006" "0.901" "0.866" "1.052" "0.960" "1.161" "0.974" "0.842" "1.460" "83.8" "84.3" "75.5" "72.6" "88.1" "80.4" "97.3" "81.7" "70.5" "122.3" "" "" "" "" "" "" "" "" "" "" "75.3" "68.2" "68.3" "70.9" "72.7" "80.4" "72.9" "72.1" "63.1" "43.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5203794321803300352" "False" "High" "IsMasterProtein" "Q9UKI3" "Pre-B lymphocyte protein 3 OS=Homo sapiens OX=9606 GN=VPREB3 PE=1 SV=1" "0.000" "False" "6.419" "11" "1" "6" "1" "123" "13.7" "5.36" "5.67" "1" "other biological processes" "non-structural extracellular;ER/Golgi" "" "Pf07686" "29802" "ENSG00000128218" "VPREB3" "B2R587; hsa:29802; Q9UKI3" "" "Cell surface interactions at the vascular wall" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3143517004493314389" "False" "High" "IsMasterProtein" "Q01970" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 OS=Homo sapiens OX=9606 GN=PLCB3 PE=1 SV=2" "0.000" "False" "6.416" "2" "2" "2" "2" "1234" "138.7" "5.90" "7.52" "2" "other metabolic processes;transport;signal transduction;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5331" "ENSG00000149782" "PLCB3" "A5PKZ6; G5E960; hsa:5331; Q01970; Q8N1A4" "Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Myometrial relaxation and contraction pathways; G protein signaling pathways; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; GPR40 pathway; MAPK cascade; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease; Calcium regulation in cardiac cells" "G alpha (q) signalling events; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; PLC beta mediated events; Acetylcholine regulates insulin secretion" "26" "0" "0.760" "0.923" "0.922" "0.856" "1.032" "1.059" "0.877" "0.779" "0.751" "42.6" "32.4" "39.3" "39.2" "36.4" "43.9" "45.1" "37.3" "33.2" "32.0" "" "" "" "" "" "" "" "" "" "" "38.3" "26.2" "35.5" "38.3" "30.1" "43.9" "33.8" "33.0" "29.7" "11.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1999120718507000118" "False" "High" "IsMasterProtein" "P17707" "S-adenosylmethionine decarboxylase proenzyme OS=Homo sapiens OX=9606 GN=AMD1 PE=1 SV=2" "0.000" "False" "6.415" "5" "2" "2" "2" "334" "38.3" "6.00" "6.09" "2" "other metabolic processes" "cytosol" "other molecular function" "Pf01536" "262" "ENSG00000123505" "AMD1" "E1P5F7; hsa:262; P17707; Q5VXN4; Q5VXN6; Q9BWK4" "Methionine de novo and salvage pathway" "Metabolism of polyamines" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5521587421576138717" "False" "High" "IsMasterProtein" "Q12800" "Alpha-globin transcription factor CP2 OS=Homo sapiens OX=9606 GN=TFCP2 PE=1 SV=2" "0.000" "False" "6.414" "5" "2" "4" "1" "502" "57.2" "5.80" "4.46" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04516, Pf18016" "7024" "ENSG00000135457" "TFCP2" "A8K5E9; hsa:7024; Q12800; Q12801; Q9UD75; Q9UD77" "VEGFA-VEGFR2 signaling" "" "1" "0" "1.294" "1.327" "0.858" "1.224" "1.191" "1.280" "1.060" "1.274" "1.290" "33.3" "43.1" "44.2" "28.6" "40.8" "39.7" "42.7" "35.3" "42.5" "43.0" "" "" "" "" "" "" "" "" "" "" "30.0" "34.9" "40.0" "27.9" "33.7" "39.7" "31.9" "31.2" "38.0" "15.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1654443810418690353" "False" "High" "IsMasterProtein" "Q9UJU2" "Lymphoid enhancer-binding factor 1 OS=Homo sapiens OX=9606 GN=LEF1 PE=1 SV=1" "0.000" "False" "6.396" "6" "2" "2" "2" "399" "44.2" "7.42" "4.39" "2" "cell adhesion;cell-cell signaling;cell cycle OR cell proliferation;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf08347" "51176" "ENSG00000138795" "LEF1" "B4DG38; B7Z8E2; E9PDK3; hsa:51176; Q3ZCU4; Q9HAZ0; Q9UJU2" "Arrhythmogenic right ventricular cardiomyopathy; Endoderm differentiation; Mesodermal commitment pathway; Mesodermal commitment pathway; Wnt signaling pathway; Hepatitis C and hepatocellular carcinoma; Wnt/beta-catenin signaling pathway in leukemia; Regulation of Wnt / B-catenin signaling by small molecule compounds; Amplification and expansion of oncogenic pathways as metastatic traits; Canonical and non-canonical Notch signaling; Wnt signaling pathway and pluripotency; Endometrial cancer; Chromosomal and microsatellite instability in colorectal cancer ; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; Effect of progerin on genes involved in progeria; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Hippo signaling regulation pathways; TGF-beta receptor signaling in skeletal dysplasias; Influence of laminopathies on Wnt signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Pleural mesothelioma; Acute myeloid leukemia; 11p11.2 copy number variation syndrome ; Cell lineage map for neuronal differentiation; TGF-beta receptor signaling; DNA damage response (only ATM dependent)" "Ca2+ pathway; Formation of paraxial mesoderm; Somitogenesis; Formation of axial mesoderm; Deactivation of the beta-catenin transactivating complex; Transcriptional Regulation by VENTX; Cardiogenesis; Germ layer formation at gastrulation; Transcriptional regulation of granulopoiesis; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; Repression of WNT target genes" "41" "0" "1.073" "1.074" "1.095" "1.188" "1.031" "1.045" "1.059" "1.162" "4.081" "103.1" "110.5" "110.7" "112.8" "122.4" "106.2" "107.7" "109.1" "119.8" "420.6" "" "" "" "" "" "" "" "" "" "" "92.7" "89.4" "100.1" "110.1" "101.0" "106.2" "80.7" "96.4" "107.2" "150.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5181801566147429502" "False" "High" "IsMasterProtein" "Q9UHV7" "Mediator of RNA polymerase II transcription subunit 13 OS=Homo sapiens OX=9606 GN=MED13 PE=1 SV=3" "0.000" "False" "6.372" "1" "3" "3" "3" "2174" "239.1" "5.64" "8.55" "3" "other biological processes" "nucleus" "other molecular function" "Pf06333, Pf18296" "9969" "ENSG00000108510" "MED13" "B2RU05; hsa:9969; O60334; Q9UHV7" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "0.885" "0.901" "0.925" "0.917" "0.877" "0.770" "0.922" "0.762" "0.685" "122.2" "108.2" "110.1" "113.1" "112.0" "107.2" "94.1" "112.7" "93.2" "83.7" "" "" "" "" "" "" "" "" "" "" "109.9" "87.5" "99.6" "110.4" "92.5" "107.2" "70.4" "99.5" "83.4" "29.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2436656635601103317" "False" "High" "IsMasterProtein" "Q3ZCW2" "Galectin-related protein OS=Homo sapiens OX=9606 GN=LGALSL PE=1 SV=2" "0.000" "False" "6.364" "12" "2" "2" "2" "172" "19.0" "5.35" "3.45" "2" "" "" "other molecular function" "Pf00337" "29094" "ENSG00000119862" "LGALSL" "B2RBG8; D6W5E8; hsa:29094; Q3ZCW2; Q6P5T6; Q9P005" "" "" "0" "0" "1.121" "0.913" "0.939" "0.895" "0.810" "0.741" "0.905" "0.907" "0.875" "153.4" "172.0" "140.0" "144.0" "137.3" "124.2" "113.7" "138.8" "139.1" "134.3" "" "" "" "" "" "" "" "" "" "" "137.9" "139.2" "126.7" "140.5" "113.3" "124.2" "85.2" "122.6" "124.5" "47.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1745587393754728304" "False" "High" "IsMasterProtein" "Q9NQZ2" "Something about silencing protein 10 OS=Homo sapiens OX=9606 GN=UTP3 PE=1 SV=1" "0.000" "False" "6.361" "7" "2" "2" "2" "479" "54.5" "5.62" "7.72" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "" "Pf04000, Pf09368" "57050" "ENSG00000132467" "UTP3" "hsa:57050; Q6FI82; Q9NQZ2" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.906" "0.678" "0.849" "0.884" "0.806" "0.934" "0.722" "0.725" "0.755" "25.2" "22.8" "17.1" "21.4" "22.3" "20.3" "23.6" "18.2" "18.3" "19.0" "" "" "" "" "" "" "" "" "" "" "22.7" "18.5" "15.5" "20.9" "18.4" "20.3" "17.6" "16.1" "16.4" "6.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3508649530452010436" "False" "High" "IsMasterProtein" "P00167" "Cytochrome b5 OS=Homo sapiens OX=9606 GN=CYB5A PE=1 SV=2" "0.000" "False" "6.355" "20" "2" "2" "2" "134" "15.3" "4.96" "8.29" "2" "transport" "other membranes;cytosol;mitochondrion;ER/Golgi;other cell component" "transporter activity;other molecular function" "Pf00173" "1528" "ENSG00000166347" "CYB5A" "A8MV91; F8WEU4; hsa:1528; P00167; Q6IB14" "Oxidation by cytochrome P450" "Vitamin C (ascorbate) metabolism" "2" "0" "0.852" "0.991" "0.958" "1.082" "1.101" "1.155" "1.127" "0.960" "1.182" "64.3" "54.8" "63.8" "61.6" "69.6" "70.8" "74.3" "72.5" "61.8" "76.1" "" "" "" "" "" "" "" "" "" "" "57.8" "44.4" "57.7" "60.2" "57.4" "70.8" "55.7" "64.0" "55.3" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "864324901755663317" "False" "High" "IsMasterProtein" "Q8TAP9" "M-phase-specific PLK1-interacting protein OS=Homo sapiens OX=9606 GN=MPLKIP PE=1 SV=1" "0.000" "False" "6.352" "19" "2" "2" "2" "179" "19.1" "10.23" "9.54" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "" "Pf15502" "136647" "ENSG00000168303" "MPLKIP" "hsa:136647; Q8TAP9" "" "" "0" "0" "0.919" "0.991" "0.909" "0.897" "0.934" "0.851" "0.843" "0.841" "0.857" "155.8" "143.2" "154.4" "141.6" "139.7" "145.4" "132.6" "131.4" "131.1" "133.4" "" "" "" "" "" "" "" "" "" "" "140.1" "115.8" "139.7" "138.2" "115.3" "145.4" "99.3" "116.0" "117.3" "47.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3133890418348041849" "False" "High" "IsMasterProtein" "Q5T6F0" "DDB1- and CUL4-associated factor 12 OS=Homo sapiens OX=9606 GN=DCAF12 PE=1 SV=1" "0.000" "False" "6.341" "4" "2" "2" "2" "453" "50.5" "9.10" "6.46" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00400" "25853" "ENSG00000198876" "DCAF12" "A8KA70; D3DRL6; hsa:25853; Q5T6E9; Q5T6F0; Q5T6F1; Q6P3V0; Q7L4F8; Q96PZ5; Q9NXA9; Q9UFJ1" "" "" "0" "0" "1.314" "1.185" "1.032" "1.169" "1.057" "1.273" "1.204" "1.090" "1.162" "141.0" "185.3" "167.1" "145.5" "164.9" "149.0" "179.5" "169.7" "153.6" "163.8" "" "" "" "" "" "" "" "" "" "" "126.8" "149.9" "151.1" "142.0" "136.0" "149.0" "134.4" "149.9" "137.5" "58.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "894930863063919588" "False" "High" "IsMasterProtein" "Q86W34" "Archaemetzincin-2 OS=Homo sapiens OX=9606 GN=AMZ2 PE=1 SV=2" "0.000" "False" "6.338" "7" "2" "2" "2" "360" "41.2" "8.15" "9.71" "2" "protein metabolism" "" "other molecular function" "Pf07998" "51321" "ENSG00000196704" "AMZ2" "A6NLD9; B3KR44; hsa:51321; Q5XKF1; Q86W34; Q9NZE2" "" "" "0" "0" "0.999" "0.951" "0.952" "1.013" "0.850" "0.943" "0.819" "0.843" "1.451" "202.2" "201.9" "192.3" "192.5" "204.8" "171.8" "190.7" "165.7" "170.5" "293.3" "" "" "" "" "" "" "" "" "" "" "181.8" "163.4" "173.9" "187.9" "169.0" "171.8" "142.8" "146.3" "152.6" "104.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3588052474242389854" "False" "High" "IsMasterProtein" "Q92766" "Ras-responsive element-binding protein 1 OS=Homo sapiens OX=9606 GN=RREB1 PE=1 SV=3" "0.000" "False" "6.315" "2" "3" "3" "3" "1687" "181.3" "6.98" "8.23" "3" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894, Pf13912" "6239" "ENSG00000124782" "RREB1" "A2RRF5; E2GM80; E2GM81; hsa:6239; O75567; O75568; Q5VYB2; Q6BEP5; Q6BEP6; Q6BEP8; Q86SU2; Q92766; Q9Y474" "" "" "0" "0" "1.104" "1.080" "1.424" "1.520" "1.403" "1.315" "0.992" "1.319" "0.657" "12.5" "13.8" "13.5" "17.8" "19.0" "17.6" "16.5" "12.4" "16.5" "8.2" "" "" "" "" "" "" "" "" "" "" "11.3" "11.2" "12.2" "17.4" "15.7" "17.6" "12.3" "11.0" "14.8" "2.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3499966319797164374" "False" "High" "IsMasterProtein" "Q9UKZ1" "CCR4-NOT transcription complex subunit 11 OS=Homo sapiens OX=9606 GN=CNOT11 PE=1 SV=1" "0.000" "False" "6.311" "5" "2" "2" "2" "510" "55.2" "6.40" "7.58" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf10155" "55571" "ENSG00000158435" "CNOT11" "hsa:55571; Q6P2M9; Q8N681; Q9UKZ1" "" "Deadenylation of mRNA; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain; M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "0.939" "0.912" "0.861" "0.874" "0.788" "0.963" "0.965" "0.892" "1.269" "186.3" "175.0" "169.9" "160.5" "162.8" "146.8" "179.4" "179.9" "166.2" "236.5" "" "" "" "" "" "" "" "" "" "" "167.5" "141.6" "153.7" "156.7" "134.3" "146.8" "134.3" "158.9" "148.8" "84.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2089333689475724176" "False" "High" "IsMasterProtein" "Q9BTM9" "Ubiquitin-related modifier 1 OS=Homo sapiens OX=9606 GN=URM1 PE=1 SV=1" "0.000" "False" "6.279" "13" "1" "2" "1" "101" "11.4" "4.67" "8.95" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf09138" "81605" "ENSG00000167118" "URM1" "B3KMH3; B4DV08; hsa:81605; Q5T4B4; Q9BTM9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.057" "1.421" "0.949" "1.280" "0.916" "1.077" "0.933" "0.998" "0.941" "120.8" "127.7" "171.7" "114.6" "154.6" "110.6" "130.1" "112.7" "120.6" "113.6" "" "" "" "" "" "" "" "" "" "" "108.6" "103.3" "155.3" "111.9" "127.6" "110.6" "97.4" "99.6" "107.9" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4759228075821596448" "False" "High" "IsMasterProtein" "Q8IZD2" "Inactive histone-lysine N-methyltransferase 2E OS=Homo sapiens OX=9606 GN=KMT2E PE=1 SV=1" "0.000" "False" "6.277" "1" "2" "2" "2" "1858" "204.8" "7.61" "4.95" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00856, Pf20826" "55904" "ENSG00000005483" "KMT2E" "B6ZDE4; B6ZDM3; hsa:55904; M4K8J3; Q6P5Y2; Q6PKG4; Q6T316; Q86TI3; Q86W12; Q86WG0; Q86WL2; Q8IV78; Q8IWR5; Q8IZD2; Q8NFF8; Q9NWE7" "Histone modifications" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5445145338916724617" "False" "High" "IsMasterProtein" "Q9H9L7" "Akirin-1 OS=Homo sapiens OX=9606 GN=AKIRIN1 PE=1 SV=1" "0.000" "False" "6.253" "10" "2" "3" "1" "192" "21.9" "8.69" "9.63" "2" "other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "" "79647" "ENSG00000174574" "AKIRIN1" "B4DZU6; hsa:79647; Q0VDB3; Q53FK8; Q9H9L7" "" "" "0" "0" "0.991" "1.061" "0.960" "0.997" "1.071" "1.016" "1.011" "1.186" "0.985" "184.3" "182.6" "195.4" "176.9" "183.8" "197.4" "187.2" "186.3" "218.5" "181.4" "" "" "" "" "" "" "" "" "" "" "165.7" "147.7" "176.8" "172.7" "151.6" "197.4" "140.2" "164.5" "195.5" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6857356928160301149" "False" "High" "IsMasterProtein" "Q9C0E8" "Endoplasmic reticulum junction formation protein lunapark OS=Homo sapiens OX=9606 GN=LNPK PE=1 SV=2" "0.000" "False" "6.248" "2" "1" "2" "1" "428" "47.7" "5.11" "6.27" "1" "cell organization and biogenesis;stress response;developmental processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "Pf10058" "80856" "ENSG00000144320" "LNPK" "B7ZLA8; hsa:80856; Q2M2V8; Q2YD99; Q658W8; Q8N5V9; Q96MS5; Q9C0E8" "" "" "0" "0" "0.909" "1.010" "1.027" "0.836" "1.028" "1.188" "1.053" "0.978" "0.896" "91.6" "83.3" "92.5" "94.0" "76.5" "94.1" "108.8" "96.4" "89.5" "82.0" "" "" "" "" "" "" "" "" "" "" "82.3" "67.4" "83.6" "91.8" "63.2" "94.1" "81.5" "85.1" "80.1" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1697211468385276031" "False" "High" "IsMasterProtein" "P62861" "Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein OS=Homo sapiens OX=9606 GN=FAU PE=1 SV=2" "0.000" "False" "6.247" "8" "1" "3" "1" "133" "14.4" "10.17" "9.63" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00240, Pf04758" "2197" "ENSG00000149806" "FAU" "hsa:2197; P35544; P62861; Q05472; Q95261; Q9H5V4" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; SARS-CoV-2 modulates host translation machinery; SRP-dependent cotranslational protein targeting to membrane; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6309414575858280989" "False" "High" "IsMasterProtein" "Q9GZQ3" "COMM domain-containing protein 5 OS=Homo sapiens OX=9606 GN=COMMD5 PE=1 SV=1" "0.000" "False" "6.225" "13" "2" "2" "2" "224" "24.7" "7.02" "7.22" "2" "" "cytosol;nucleus" "" "Pf07258, Pf21672" "28991" "ENSG00000170619" "COMMD5" "D3DWN7; hsa:28991; Q9GZQ3; Q9NVN6; Q9UHX5" "" "Neddylation" "1" "0" "0.770" "0.946" "0.879" "0.881" "0.824" "0.758" "0.862" "0.909" "0.796" "145.4" "111.9" "137.5" "127.8" "128.1" "119.8" "110.1" "125.3" "132.1" "115.7" "" "" "" "" "" "" "" "" "" "" "130.7" "90.6" "124.3" "124.8" "105.7" "119.8" "82.5" "110.7" "118.2" "41.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6256207077144686062" "False" "High" "IsMasterProtein" "Q9UK61" "Protein TASOR OS=Homo sapiens OX=9606 GN=TASOR PE=1 SV=3" "0.000" "False" "6.214" "1" "2" "2" "2" "1670" "188.9" "5.80" "6.69" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12509" "23272" "ENSG00000163946" "TASOR" "A1L3A4; B5ME28; hsa:23272; Q9H2F7; Q9UK61; Q9UPP7" "" "" "0" "0" "0.991" "0.970" "1.019" "0.986" "1.033" "1.029" "0.962" "0.976" "1.282" "224.7" "222.8" "218.0" "229.0" "221.7" "232.1" "231.3" "216.3" "219.4" "288.1" "" "" "" "" "" "" "" "" "" "" "202.1" "180.3" "197.1" "223.6" "182.9" "232.1" "173.2" "191.0" "196.3" "102.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9132635867397603913" "False" "High" "IsMasterProtein" "Q53T59" "HCLS1-binding protein 3 OS=Homo sapiens OX=9606 GN=HS1BP3 PE=1 SV=1" "0.000" "False" "6.212" "6" "2" "2" "2" "392" "42.8" "5.01" "6.09" "2" "other biological processes" "mitochondrion;ER/Golgi" "other molecular function" "Pf00787" "64342" "ENSG00000118960" "HS1BP3" "B2RAW2; D6W529; hsa:64342; Q53T59; Q86VC2; Q8N367" "" "" "0" "0" "1.286" "1.235" "1.213" "1.275" "1.155" "1.093" "1.087" "1.255" "1.542" "68.1" "87.6" "84.1" "82.6" "86.8" "78.6" "74.4" "74.0" "85.4" "104.9" "" "" "" "" "" "" "" "" "" "" "61.2" "70.9" "76.0" "80.6" "71.6" "78.6" "55.7" "65.4" "76.4" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8582316469479536789" "False" "High" "IsMasterProtein" "Q92567" "Protein FAM168A OS=Homo sapiens OX=9606 GN=FAM168A PE=1 SV=2" "0.000" "False" "6.207" "7" "2" "3" "2" "244" "26.2" "8.98" "11.73" "2" "other biological processes" "" "" "Pf14944" "23201" "ENSG00000054965" "FAM168A" "A2ICY2; A2ID81; hsa:23201; Q86UG2; Q92567" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6705073720058711891" "False" "High" "IsMasterProtein" "Q96BP2" "Small ribosomal subunit protein mS37 OS=Homo sapiens OX=9606 GN=CHCHD1 PE=1 SV=1" "0.000" "False" "6.206" "18" "2" "2" "2" "118" "13.5" "10.21" "3.09" "2" "protein metabolism;other metabolic processes" "other membranes;cytosol;mitochondrion;translational apparatus;nucleus" "" "Pf06747" "118487" "ENSG00000172586" "CHCHD1" "hsa:118487; Q96BP2" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.995" "0.976" "0.867" "1.038" "1.118" "0.965" "1.006" "1.074" "1.220" "118.0" "117.3" "115.1" "102.3" "122.5" "131.9" "113.9" "118.7" "126.6" "143.9" "" "" "" "" "" "" "" "" "" "" "106.1" "95.0" "104.1" "99.8" "101.0" "131.9" "85.3" "104.8" "113.3" "51.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6124649354194379211" "False" "High" "IsMasterProtein" "Q9P2B7" "Cilia- and flagella-associated protein 97 OS=Homo sapiens OX=9606 GN=CFAP97 PE=1 SV=2" "0.000" "False" "6.195" "3" "2" "2" "2" "532" "59.4" "9.06" "6.97" "2" "other biological processes" "" "" "Pf13879" "57587" "ENSG00000164323" "CFAP97" "B3KRP7; D3DP60; hsa:57587; Q05CU1; Q4W5M4; Q8N6E7; Q9P2B7; Q9UF45" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1253491667474382087" "False" "High" "IsMasterProtein" "Q9Y4D1" "Disheveled-associated activator of morphogenesis 1 OS=Homo sapiens OX=9606 GN=DAAM1 PE=1 SV=2" "0.000" "False" "6.194" "2" "2" "3" "2" "1078" "123.4" "7.23" "4.93" "2" "cell-cell signaling;cell organization and biogenesis;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "23002" "ENSG00000100592" "DAAM1" "hsa:23002; Q86U34; Q8N1Z8; Q8TB39; Q9Y4D1" "Physico-chemical features and toxicity-associated pathways; Wnt signaling" "RHO GTPases Activate Formins; RHOA GTPase cycle; CDC42 GTPase cycle; RHOC GTPase cycle; RHOB GTPase cycle; PCP/CE pathway" "8" "0" "1.112" "1.043" "0.922" "1.238" "1.133" "1.280" "0.916" "0.970" "0.970" "106.4" "118.3" "111.0" "98.1" "131.8" "120.6" "136.2" "97.4" "103.3" "103.3" "" "" "" "" "" "" "" "" "" "" "95.7" "95.7" "100.4" "95.7" "108.7" "120.6" "102.0" "86.1" "92.4" "36.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2325443013124673649" "False" "High" "IsMasterProtein" "Q6NXE6" "Armadillo repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=ARMC6 PE=1 SV=2" "0.000" "False" "6.180" "4" "2" "2" "2" "501" "54.1" "6.24" "6.63" "2" "other biological processes" "cytosol" "" "Pf00514" "93436" "ENSG00000105676" "ARMC6" "B4DI98; hsa:93436; O94999; Q6NXE6; Q9BTH5" "" "" "0" "0" "0.870" "0.920" "0.852" "1.008" "0.963" "0.963" "0.870" "0.916" "3.018" "236.1" "205.4" "217.3" "201.1" "237.8" "227.4" "227.4" "205.5" "216.2" "712.5" "" "" "" "" "" "" "" "" "" "" "212.2" "166.2" "196.5" "196.3" "196.3" "227.4" "170.3" "181.5" "193.4" "254.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5146194763557846941" "False" "High" "IsMasterProtein" "Q9Y613" "FH1/FH2 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FHOD1 PE=1 SV=3" "0.000" "False" "6.176" "2" "2" "2" "2" "1164" "126.5" "6.39" "6.18" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf18382" "29109" "ENSG00000135723" "FHOD1" "hsa:29109; Q59F76; Q6Y1F2; Q76MS8; Q8N521; Q9Y613" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7945924760519134314" "False" "High" "IsMasterProtein" "Q9H9C1" "Spermatogenesis-defective protein 39 homolog OS=Homo sapiens OX=9606 GN=VIPAS39 PE=1 SV=1" "0.000" "False" "6.172" "4" "2" "2" "2" "493" "57.0" "7.40" "7.27" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf04840" "63894" "ENSG00000151445" "VIPAS39" "B4DPI6; hsa:63894; O95434; Q9H7E1; Q9H9C1; Q9H9I9" "" "" "0" "0" "1.012" "1.012" "1.168" "0.970" "0.989" "1.221" "1.035" "1.045" "2.912" "142.5" "144.2" "144.2" "166.4" "138.3" "140.9" "174.1" "147.5" "149.0" "415.1" "" "" "" "" "" "" "" "" "" "" "128.2" "116.7" "130.5" "162.5" "114.2" "140.9" "130.3" "130.2" "133.3" "148.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1244063578202926483" "False" "High" "IsMasterProtein" "Q68D10" "Protein SPT2 homolog OS=Homo sapiens OX=9606 GN=SPTY2D1 PE=1 SV=3" "0.000" "False" "6.168" "4" "2" "4" "2" "685" "75.6" "9.79" "7.92" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf08243" "144108" "ENSG00000179119" "SPTY2D1" "hsa:144108; Q68D10; Q6AWA5; Q6MZI5; Q7Z390; Q7Z470; Q86VG8; Q8N3E7; Q8N417; Q8N8I3" "" "" "0" "0" "0.927" "1.014" "0.855" "0.979" "1.220" "0.998" "0.847" "1.062" "1.157" "93.4" "86.5" "94.6" "79.8" "91.4" "113.9" "93.2" "79.1" "99.2" "108.0" "" "" "" "" "" "" "" "" "" "" "83.9" "70.0" "85.6" "77.9" "75.5" "113.9" "69.8" "69.8" "88.7" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1516422207583123109" "False" "High" "IsMasterProtein" "Q9NUD5" "Zinc finger CCHC domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZCCHC3 PE=1 SV=2" "0.000" "False" "6.166" "5" "2" "2" "2" "403" "43.5" "8.53" "5.77" "2" "stress response;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00098" "85364" "ENSG00000247315" "ZCCHC3" "hsa:85364; Q3B7J3; Q6NT79; Q9NUD5" "" "" "0" "0" "0.997" "0.830" "1.038" "0.628" "0.971" "1.012" "1.054" "0.795" "0.876" "33.1" "33.0" "27.5" "34.4" "20.8" "32.2" "33.5" "34.9" "26.4" "29.0" "" "" "" "" "" "" "" "" "" "" "29.8" "26.7" "24.9" "33.6" "17.2" "32.2" "25.1" "30.8" "23.6" "10.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6723656292985318404" "False" "High" "IsMasterProtein" "Q9Y255" "PRELI domain-containing protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=PRELID1 PE=1 SV=1" "0.000" "False" "6.166" "8" "2" "2" "2" "219" "25.2" "9.54" "7.62" "2" "cell organization and biogenesis;transport;other biological processes" "mitochondrion;nucleus;other cell component" "" "Pf04707" "27166" "ENSG00000169230" "PRELID1" "B2R5F7; D6RD25; hsa:27166; Q549N2; Q9UI13; Q9UJS9; Q9Y255" "5q35 copy number variation" "Mitochondrial protein degradation; TP53 Regulates Transcription of Genes Involved in Cytochrome C Release" "3" "0" "1.073" "1.078" "0.995" "1.076" "1.061" "1.056" "1.004" "1.058" "0.888" "212.6" "228.0" "229.2" "211.4" "228.7" "225.5" "224.5" "213.5" "225.0" "188.8" "" "" "" "" "" "" "" "" "" "" "191.1" "184.5" "207.3" "206.4" "188.7" "225.5" "168.1" "188.6" "201.3" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3534429540462627294" "False" "High" "IsMasterProtein" "P09525" "Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4" "0.000" "False" "6.154" "7" "2" "2" "1" "319" "35.9" "6.13" "7.33" "2" "signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00191" "307" "ENSG00000196975" "ANXA4" "B4DDF9; hsa:307; P09525; Q6LES2; Q96F33; Q9BWK1" "Prostaglandin synthesis and regulation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8237731062455566207" "False" "High" "IsMasterProtein" "P40763" "Signal transducer and activator of transcription 3 OS=Homo sapiens OX=9606 GN=STAT3 PE=1 SV=2" "0.000" "False" "6.151" "3" "2" "2" "2" "770" "88.0" "6.30" "6.47" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf21354" "6774" "ENSG00000168610" "STAT3" "A8K7B8; hsa:6774; K7ENL3; O14916; P40763; Q9BW54" "IL-5 signaling pathway; Androgen receptor signaling pathway; Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Transcription factors regulate miRNAs related to cardiac hypertrophy; Cell differentiation - expanded index; Cell differentiation - index; Thyroid stimulating hormone (TSH) signaling pathway; Leptin signaling pathway; Prolactin signaling pathway; Microtubule cytoskeleton regulation; IL-7 signaling pathway; IL-17 signaling pathway; IL-9 signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; Androgen receptor network in prostate cancer; AGE/RAGE pathway; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); Dopaminergic neurogenesis; IL-3 signaling pathway; TCA cycle nutrient use and invasiveness of ovarian cancer; Estrogen receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; Development of pulmonary dendritic cells and macrophage subsets; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Leptin-insulin signaling overlap; IL-4 signaling pathway; PDGFR-beta pathway; Prion disease pathway; Clear cell renal cell carcinoma pathways; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Extracellular vesicles in the crosstalk of cardiac cells; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; EGF/EGFR signaling pathway; IL-10 anti-inflammatory signaling pathway ; Regulatory circuits of the STAT3 signaling pathway; Interactions between immune cells and microRNAs in tumor microenvironment; Neural crest cell migration during development; Neural crest cell migration in cancer; Cancer immunotherapy by PD-1 blockade; Measles virus infection; Gastrin signaling pathway; Hepatitis B infection; EGFR tyrosine kinase inhibitor resistance; TGF-beta receptor signaling in skeletal dysplasias; mBDNF and proBDNF regulation of GABA neurotransmission; IL-2 signaling pathway; Neuroinflammation and glutamatergic signaling; CCL18 signaling pathway; Th17 cell differentiation pathway; Urotensin-II-mediated signaling pathway; Inflammatory bowel disease signaling; 2q11.2 copy number variation syndrome; 2q21.1 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Acute myeloid leukemia; Autophagy in pancreatic ductal adenocarcinoma; IL-26 signaling pathways; JAK-STAT signaling in the regulation of beta cells; TAR syndrome; Osteoarthritic chondrocyte hypertrophy; IL-19 signaling pathway; TGF-beta receptor signaling; EPO receptor signaling; Interferon type I signaling pathways; Notch signaling pathway; Serotonin HTR1 group and FOS pathway" "Interleukin-4 and Interleukin-13 signaling; Transcriptional regulation of granulopoiesis; Senescence-Associated Secretory Phenotype (SASP); PKR-mediated signaling; Signaling by ALK fusions and activated point mutants; Interleukin-7 signaling; Signaling by SCF-KIT; Downstream signal transduction; Signaling by ALK; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Cytoprotection by HMOX1; Association of TriC/CCT with target proteins during biosynthesis; Interleukin-10 signaling; Growth hormone receptor signaling; Interleukin-6 signaling; Signaling by Leptin; PTK6 Activates STAT3; Signaling by CSF3 (G-CSF); Inactivation of CSF3 (G-CSF) signaling; Signaling by cytosolic FGFR1 fusion mutants; Signaling by CSF1 (M-CSF) in myeloid cells; STAT3 nuclear events downstream of ALK signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation; Interleukin-20 family signaling; Interleukin-35 Signalling; Interleukin-23 signaling; Interleukin-27 signaling; Interleukin-37 signaling; Signalling to STAT3; Nuclear events stimulated by ALK signaling in cancer; MET activates STAT3; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "119" "0" "1.063" "1.082" "0.916" "1.015" "0.995" "1.031" "1.007" "1.088" "1.160" "255.2" "271.3" "276.2" "233.6" "259.0" "253.9" "263.1" "256.9" "277.7" "295.9" "" "" "" "" "" "" "" "" "" "" "229.4" "219.5" "249.8" "228.0" "213.8" "253.9" "197.0" "227.0" "248.5" "105.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1828666302567516124" "False" "High" "IsMasterProtein" "Q6P2H3" "Centrosomal protein of 85 kDa OS=Homo sapiens OX=9606 GN=CEP85 PE=1 SV=1" "0.000" "False" "6.143" "3" "2" "2" "2" "762" "85.6" "6.00" "6.97" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "" "64793" "ENSG00000130695" "CEP85" "B4DRL1; D3DPK4; F8W7K4; hsa:64793; Q5VY68; Q5VY70; Q6P2H3; Q9H6Q1; Q9H828; Q9UF52" "" "" "0" "0" "1.038" "1.241" "1.118" "1.354" "1.339" "1.159" "1.038" "1.222" "1.572" "31.3" "32.5" "38.9" "35.0" "42.4" "41.9" "36.3" "32.5" "38.3" "49.2" "" "" "" "" "" "" "" "" "" "" "28.2" "26.3" "35.2" "34.2" "35.0" "41.9" "27.2" "28.7" "34.2" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8633064063620321085" "False" "High" "IsMasterProtein" "Q6PGP7" "Superkiller complex protein 3 OS=Homo sapiens OX=9606 GN=SKIC3 PE=1 SV=1" "0.000" "False" "6.120" "2" "2" "2" "2" "1564" "175.4" "7.53" "6.48" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf13181, Pf13432, Pf14559" "9652" "ENSG00000198677" "SKIC3" "hsa:9652; O15077; Q6PGP7; Q6PJI3" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "0.932" "0.905" "1.029" "0.972" "0.904" "1.079" "0.854" "0.838" "1.211" "72.4" "67.5" "65.5" "74.5" "70.4" "65.5" "78.1" "61.8" "60.7" "87.7" "" "" "" "" "" "" "" "" "" "" "65.1" "54.6" "59.3" "72.7" "58.1" "65.5" "58.5" "54.6" "54.3" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8593610449357646347" "False" "High" "IsMasterProtein" "P0C2W1" "F-box/SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FBXO45 PE=1 SV=1" "0.000" "False" "6.119" "7" "2" "2" "2" "286" "30.6" "7.83" "5.80" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00622, Pf12937" "200933" "ENSG00000174013" "FBXO45" "A6NF90; D3DXB5; hsa:200933; P0C2W1" "3q29 copy number variation syndrome" "" "1" "0" "1.134" "1.031" "1.119" "1.082" "1.176" "1.115" "0.958" "1.075" "1.260" "134.5" "152.6" "138.7" "150.6" "145.5" "158.3" "150.0" "128.9" "144.6" "169.6" "" "" "" "" "" "" "" "" "" "" "121.0" "123.4" "125.5" "147.0" "120.1" "158.3" "112.4" "113.8" "129.4" "60.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2926679715344885449" "False" "High" "IsMasterProtein" "O94913" "Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens OX=9606 GN=PCF11 PE=1 SV=3" "0.000" "False" "6.113" "2" "3" "3" "3" "1555" "172.9" "8.48" "6.51" "3" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04818, Pf11526, Pf20827, Pf20844, Pf20845" "51585" "ENSG00000165494" "PCF11" "A6H8W7; hsa:51585; O43671; O94913; Q6P0X8" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; RNA polymerase II transcribes snRNA genes; Processing of Intronless Pre-mRNAs" "5" "0" "1.063" "0.979" "0.805" "0.935" "0.952" "0.959" "0.824" "0.868" "1.713" "236.2" "251.1" "231.2" "190.1" "220.9" "224.9" "226.6" "194.6" "205.0" "404.6" "" "" "" "" "" "" "" "" "" "" "212.4" "203.1" "209.1" "185.6" "182.3" "224.9" "169.7" "171.9" "183.4" "144.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5300611953044969662" "False" "High" "IsMasterProtein" "Q9BSJ5" "Mitochondrial nucleoid-associated protein 1 OS=Homo sapiens OX=9606 GN=MTNAP1 PE=1 SV=2" "0.000" "False" "6.099" "5" "3" "4" "3" "609" "67.3" "9.16" "7.11" "3" "" "other membranes" "" "" "55028" "ENSG00000141219" "C17orf80" "A8K9X3; Q5JB45; Q6YAU3; Q9BSJ5; Q9H0L9; Q9H5E6; Q9NWN5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2465041974174611566" "False" "High" "IsMasterProtein" "Q96BT7" "Alkylated DNA repair protein alkB homolog 8 OS=Homo sapiens OX=9606 GN=ALKBH8 PE=1 SV=2" "0.000" "False" "6.098" "3" "3" "3" "3" "664" "75.2" "7.99" "7.50" "3" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076, Pf08241, Pf09004, Pf13532" "91801" "ENSG00000137760" "ALKBH8" "B1Q2M0; B4DEF6; hsa:91801; Q8N989; Q96BT7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.110" "1.050" "0.977" "1.093" "1.000" "1.136" "0.950" "0.971" "1.871" "84.0" "93.3" "88.3" "82.1" "91.8" "84.0" "95.4" "79.9" "81.6" "157.2" "" "" "" "" "" "" "" "" "" "" "75.6" "75.5" "79.8" "80.1" "75.8" "84.0" "71.5" "70.5" "73.0" "56.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2414375605373432376" "False" "High" "IsMasterProtein" "Q8TCU4" "Centrosome-associated protein ALMS1 OS=Homo sapiens OX=9606 GN=ALMS1 PE=1 SV=4" "0.000" "False" "6.056" "1" "3" "3" "3" "4168" "460.8" "6.28" "6.87" "3" "transport;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309, Pf18727" "7840" "ENSG00000116127" "ALMS1" "A0A087WZY3; hsa:7840; Q53S05; Q580Q8; Q86VP9; Q8TCU4; Q9Y4G4" "Ciliopathies; Alstrom syndrome" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "9" "0" "0.907" "0.997" "0.865" "0.897" "0.841" "0.845" "1.129" "0.875" "1.127" "23.3" "21.1" "23.2" "20.2" "20.9" "19.6" "19.7" "26.3" "20.4" "26.3" "" "" "" "" "" "" "" "" "" "" "21.0" "17.1" "21.0" "19.7" "17.3" "19.6" "14.7" "23.3" "18.3" "9.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3055099900900343627" "False" "High" "IsMasterProtein" "Q9P0M9" "Large ribosomal subunit protein bL27m OS=Homo sapiens OX=9606 GN=MRPL27 PE=1 SV=1" "0.000" "False" "6.052" "13" "2" "2" "2" "148" "16.1" "10.42" "6.51" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01016" "51264" "ENSG00000108826" "MRPL27" "B2RE14; hsa:51264; Q9P0M9" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.037" "1.045" "1.089" "1.034" "1.106" "1.124" "1.046" "1.121" "1.250" "199.4" "206.9" "208.4" "217.1" "206.2" "220.5" "224.2" "208.5" "223.6" "249.3" "" "" "" "" "" "" "" "" "" "" "179.3" "167.4" "188.5" "211.9" "170.2" "220.5" "167.8" "184.2" "200.1" "89.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489642059379383551" "False" "High" "IsMasterProtein" "Q6PD62" "RNA polymerase-associated protein CTR9 homolog OS=Homo sapiens OX=9606 GN=CTR9 PE=1 SV=1" "0.000" "False" "6.052" "2" "2" "2" "2" "1173" "133.4" "6.77" "9.69" "2" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13181, Pf13374" "9646" "ENSG00000198730" "CTR9" "D3DQV8; hsa:9646; Q15015; Q6PD62" "Endoderm differentiation" "E3 ubiquitin ligases ubiquitinate target proteins; Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "5" "0" "1.242" "1.186" "1.210" "1.129" "1.261" "1.083" "0.971" "1.218" "3.598" "69.9" "86.8" "82.8" "84.5" "78.8" "88.1" "75.7" "67.8" "85.1" "251.4" "" "" "" "" "" "" "" "" "" "" "62.8" "70.2" "74.9" "82.5" "65.1" "88.1" "56.7" "59.9" "76.1" "89.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1984767701943514611" "False" "High" "IsMasterProtein" "Q9NQS1" "Cell death regulator Aven OS=Homo sapiens OX=9606 GN=AVEN PE=1 SV=1" "0.000" "False" "6.052" "9" "3" "3" "3" "362" "38.5" "4.98" "8.10" "3" "other biological processes" "other membranes;cytosol;other cell component" "" "" "57099" "ENSG00000169857" "AVEN" "hsa:57099; Q9NQS1" "" "Regulation of the apoptosome activity" "2" "0" "1.144" "1.004" "1.096" "0.935" "1.112" "1.115" "1.144" "1.043" "1.055" "189.3" "216.5" "190.1" "207.5" "177.1" "210.5" "211.1" "216.5" "197.5" "199.8" "" "" "" "" "" "" "" "" "" "" "170.2" "175.2" "172.0" "202.6" "146.1" "210.5" "158.0" "191.3" "176.7" "71.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3725331180764852423" "False" "High" "IsMasterProtein" "Q9ULR3" "Protein phosphatase 1H OS=Homo sapiens OX=9606 GN=PPM1H PE=1 SV=2" "0.000" "False" "6.048" "5" "2" "2" "2" "514" "56.4" "6.60" "4.95" "2" "" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00481" "57460" "ENSG00000111110" "PPM1H" "B1Q2A9; B2RXG4; hsa:57460; Q6PI86; Q9ULR3" "" "" "0" "0" "1.032" "0.920" "0.975" "1.041" "0.988" "1.138" "1.034" "1.057" "0.955" "81.3" "83.9" "74.8" "79.2" "84.6" "80.3" "92.5" "84.1" "85.9" "77.6" "" "" "" "" "" "" "" "" "" "" "73.1" "67.9" "67.6" "77.3" "69.8" "80.3" "69.3" "74.3" "76.9" "27.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7114362037868025430" "False" "High" "IsMasterProtein" "Q5THK1" "Protein PRR14L OS=Homo sapiens OX=9606 GN=PRR14L PE=1 SV=1" "0.000" "False" "6.046" "1" "2" "2" "2" "2151" "237.2" "6.33" "4.24" "2" "" "" "" "Pf15386" "253143" "ENSG00000183530" "PRR14L" "hsa:253143; Q5THK1; Q5THK4; Q6ZNN1; Q6ZWH0; Q8IW74; Q9H5T4" "" "" "0" "0" "1.013" "1.190" "1.186" "1.046" "1.093" "1.281" "1.062" "1.001" "1.683" "20.1" "20.4" "23.9" "23.8" "21.0" "22.0" "25.7" "21.3" "20.1" "33.8" "" "" "" "" "" "" "" "" "" "" "18.1" "16.5" "21.6" "23.3" "17.3" "22.0" "19.3" "18.8" "18.0" "12.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4489677363022304149" "False" "High" "IsMasterProtein" "Q8IYU8" "Calcium uptake protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=MICU2 PE=1 SV=2" "0.000" "False" "6.038" "7" "2" "2" "2" "434" "49.6" "9.09" "8.31" "2" "transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "221154" "ENSG00000165487" "MICU2" "hsa:221154; Q8IYU8; Q8N0T6; Q8NAX8" "" "Mitochondrial protein degradation; Processing of SMDT1" "3" "0" "0.910" "0.979" "0.969" "1.315" "1.050" "1.287" "1.104" "1.016" "1.346" "103.4" "94.1" "101.3" "100.2" "136.0" "108.6" "133.2" "114.2" "105.1" "139.2" "" "" "" "" "" "" "" "" "" "" "93.0" "76.1" "91.6" "97.8" "112.2" "108.6" "99.7" "100.9" "94.0" "49.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7912852613905627854" "False" "High" "IsMasterProtein" "Q01196" "Runt-related transcription factor 1 OS=Homo sapiens OX=9606 GN=RUNX1 PE=1 SV=3" "0.000" "False" "6.037" "5" "2" "2" "2" "453" "48.7" "9.35" "6.16" "2" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "861" "ENSG00000159216" "RUNX1" "A8MV94; B2RMS4; D3DSG1; hsa:861; O60472; O60473; O76047; O76089; Q01196; Q13081; Q13755; Q13756; Q13757; Q13758; Q13759; Q15341; Q15343; Q16122; Q16284; Q16285; Q16286; Q16346; Q16347; Q92479" "Hematopoietic stem cell differentiation; Dual hijack model of Vif in HIV infection; Orexin receptor pathway; Th17 cell differentiation pathway; Acute myeloid leukemia" "Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RUNX1 regulates expression of components of tight junctions; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; RUNX1 regulates estrogen receptor mediated transcription; RUNX1 regulates transcription of genes involved in WNT signaling; Organic cation transport; SARS-CoV-1 activates/modulates innate immune responses; Transcriptional regulation of granulopoiesis; RUNX3 regulates p14-ARF; RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs); RUNX1 regulates transcription of genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in interleukin signaling; Regulation of RUNX1 Expression and Activity; RUNX2 regulates genes involved in differentiation of myeloid cells; RUNX1 regulates transcription of genes involved in BCR signaling" "24" "0" "0.990" "0.850" "0.969" "1.050" "0.900" "1.025" "0.866" "0.904" "1.366" "65.0" "64.3" "55.3" "63.0" "68.3" "58.5" "66.7" "56.3" "58.8" "88.8" "" "" "" "" "" "" "" "" "" "" "58.5" "52.1" "50.0" "61.5" "56.3" "58.5" "49.9" "49.7" "52.6" "31.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5641207754234897297" "False" "High" "IsMasterProtein" "Q9H583" "HEAT repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=HEATR1 PE=1 SV=3" "0.000" "False" "6.028" "1" "2" "2" "2" "2144" "242.2" "6.54" "5.73" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity" "Pf08146, Pf12397" "55127" "ENSG00000119285" "HEATR1" "hsa:55127; Q5T3Q8; Q6P197; Q9H583; Q9NW23" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.626" "0.756" "0.464" "0.579" "1.774" "0.570" "0.565" "0.477" "0.535" "37.1" "23.2" "28.1" "17.2" "21.5" "65.8" "21.2" "21.0" "17.7" "19.9" "" "" "" "" "" "" "" "" "" "" "33.4" "18.8" "25.4" "16.8" "17.7" "65.8" "15.9" "18.5" "15.9" "7.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1710648290314938534" "False" "High" "IsMasterProtein" "P01906" "HLA class II histocompatibility antigen, DQ alpha 2 chain OS=Homo sapiens OX=9606 GN=HLA-DQA2 PE=1 SV=2" "0.000" "False" "6.023" "7" "2" "4" "1" "255" "28.0" "4.88" "15.54" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00993, Pf07654" "3118" "ENSG00000206301; ENSG00000223793; ENSG00000225103; ENSG00000231526; ENSG00000231823; ENSG00000233192; ENSG00000237541; ENSG00000257473" "HLA-DQA2" "A2BF37; B0V0E7; hsa:3118; O19789; P01906; Q5SQ94; Q5SR04" "Allograft rejection; Ebola virus infection in host" "Downstream TCR signaling; Phosphorylation of CD3 and TCR zeta chains; Translocation of ZAP-70 to Immunological synapse; Generation of second messenger molecules; PD-1 signaling; MHC class II antigen presentation; Interferon gamma signaling" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7950804580636753897" "False" "High" "IsMasterProtein" "Q5HYI7" "Metaxin-3 OS=Homo sapiens OX=9606 GN=MTX3 PE=1 SV=2" "0.000" "False" "6.020" "5" "2" "2" "2" "312" "35.1" "7.80" "6.07" "2" "cell organization and biogenesis;transport" "other cell component" "" "Pf10568, Pf17171" "345778" "ENSG00000177034" "MTX3" "B4DL65; E9PB57; hsa:345778; Q5HYI7; Q7Z380; Q8NB92" "" "" "0" "0" "1.121" "1.136" "1.098" "1.237" "1.068" "1.113" "1.170" "1.001" "1.070" "132.7" "148.8" "150.8" "145.7" "164.1" "141.8" "147.7" "155.3" "132.9" "142.0" "" "" "" "" "" "" "" "" "" "" "119.3" "120.4" "136.4" "142.2" "135.4" "141.8" "110.6" "137.1" "118.9" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1179356982440791831" "False" "High" "IsMasterProtein" "Q6ZNW5" "GDP-D-glucose phosphorylase 1 OS=Homo sapiens OX=9606 GN=GDPGP1 PE=1 SV=2" "0.000" "False" "6.009" "7" "2" "2" "2" "385" "42.3" "6.47" "8.89" "2" "other metabolic processes" "other cell component" "enzyme regulator activity;other molecular function" "" "390637" "ENSG00000183208" "GDPGP1" "hsa:390637; Q6ZNW5" "" "" "0" "0" "1.080" "0.997" "1.100" "1.216" "1.079" "1.138" "1.051" "1.037" "0.927" "114.5" "123.6" "114.2" "126.0" "139.3" "123.5" "130.3" "120.3" "118.7" "106.1" "" "" "" "" "" "" "" "" "" "" "102.9" "100.0" "103.3" "122.9" "114.9" "123.5" "97.5" "106.2" "106.2" "37.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5985118232380264359" "False" "High" "IsMasterProtein" "Q15363" "Transmembrane emp24 domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TMED2 PE=1 SV=1" "0.000" "False" "6.007" "6" "1" "3" "1" "201" "22.7" "5.17" "3.93" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding" "Pf01105" "10959" "ENSG00000086598" "TMED2" "hsa:10959; Q15363" "5q35 copy number variation" "COPI-dependent Golgi-to-ER retrograde traffic; COPI-mediated anterograde transport; Pre-NOTCH Processing in Golgi; COPII-mediated vesicle transport; Cargo concentration in the ER" "6" "0" "0.979" "1.097" "1.110" "1.004" "0.904" "1.092" "1.051" "1.006" "1.090" "68.5" "67.1" "75.2" "76.1" "68.8" "62.0" "74.9" "72.0" "69.0" "74.7" "" "" "" "" "" "" "" "" "" "" "61.6" "54.3" "68.0" "74.3" "56.8" "62.0" "56.1" "63.6" "61.7" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4270729495226616365" "False" "High" "IsMasterProtein" "Q9Y535" "DNA-directed RNA polymerase III subunit RPC8 OS=Homo sapiens OX=9606 GN=POLR3H PE=1 SV=1" "0.000" "False" "6.006" "13" "2" "2" "2" "204" "22.9" "4.58" "5.33" "2" "RNA metabolism OR transcription;other metabolic processes;stress response" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03876, Pf08292" "171568" "ENSG00000100413" "POLR3H" "B0QYH9; hsa:171568; Q5M7Y8; Q96AE3; Q9BY95; Q9Y535" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; Primary ovarian insufficiency" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5632561991288096733" "False" "High" "IsMasterProtein" "Q9H9Y6" "DNA-directed RNA polymerase I subunit RPA2 OS=Homo sapiens OX=9606 GN=POLR1B PE=1 SV=2" "0.000" "False" "5.998" "2" "2" "2" "2" "1135" "128.1" "7.83" "6.56" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00562, Pf04560, Pf04561, Pf04563, Pf04565, Pf06883" "84172" "ENSG00000125630" "POLR1B" "B7Z6Y7; B7Z823; F5GZX4; F8W898; hsa:84172; Q2TAM4; Q585T5; Q6ZRR2; Q9H9D3; Q9H9Y6" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination" "8" "0" "0.939" "1.234" "0.924" "0.900" "1.058" "1.006" "0.849" "1.131" "3.077" "338.4" "317.8" "417.5" "312.8" "304.4" "358.1" "340.2" "287.3" "382.6" "1041.2" "" "" "" "" "" "" "" "" "" "" "304.2" "257.1" "377.7" "305.3" "251.2" "358.1" "254.8" "253.8" "342.3" "371.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8410241835469765050" "False" "High" "IsMasterProtein" "Q9Y2G2" "Caspase recruitment domain-containing protein 8 OS=Homo sapiens OX=9606 GN=CARD8 PE=1 SV=2" "0.000" "False" "5.997" "3" "2" "2" "2" "537" "60.6" "4.84" "6.74" "2" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf13553" "22900" "ENSG00000105483" "CARD8" "B5KVR6; B5KVR8; B7Z496; B7Z4A2; E5RFV9; E9PEM7; G3XAM9; hsa:22900; Q6PGP8; Q96P82; Q9Y2G2" "Nucleotide-binding oligomerization domain (NOD) pathway" "Regulation of the apoptosome activity" "3" "0" "1.129" "0.922" "0.973" "1.114" "1.088" "1.078" "1.055" "1.028" "1.030" "176.0" "198.6" "162.4" "171.2" "196.0" "191.5" "189.7" "185.6" "181.0" "181.3" "" "" "" "" "" "" "" "" "" "" "158.2" "160.7" "146.9" "167.2" "161.7" "191.5" "142.1" "164.0" "161.9" "64.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482571623851624299" "False" "High" "IsMasterProtein" "Q7Z6M3" "Allergin-1 OS=Homo sapiens OX=9606 GN=MILR1 PE=1 SV=2" "0.000" "False" "5.996" "6" "2" "2" "2" "343" "38.7" "7.77" "7.53" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13895, Pf17736" "284021" "ENSG00000271605" "MILR1" "A1L458; B4DUS1; B7ZM50; B9EGN0; D6RUW6; D6RUW8; hsa:284021; Q7Z6M3" "" "" "0" "0" "0.919" "1.099" "1.038" "1.003" "0.967" "1.007" "0.992" "1.017" "0.878" "150.4" "138.3" "165.3" "156.2" "150.9" "145.4" "151.5" "149.2" "153.0" "132.2" "" "" "" "" "" "" "" "" "" "" "135.3" "111.9" "149.6" "152.5" "124.6" "145.4" "113.5" "131.8" "136.9" "47.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3087130677209166127" "False" "High" "IsMasterProtein" "O43566" "Regulator of G-protein signaling 14 OS=Homo sapiens OX=9606 GN=RGS14 PE=1 SV=4" "0.000" "False" "5.994" "5" "2" "2" "2" "566" "61.4" "8.19" "5.18" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00615, Pf02188, Pf02196" "10636" "ENSG00000169220" "RGS14" "hsa:10636; O43565; O43566; Q506M1; Q6ZWA4; Q8TD62" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells; 5q35 copy number variation" "G alpha (i) signalling events" "4" "0" "0.986" "0.970" "1.070" "1.064" "0.881" "1.078" "1.064" "0.903" "1.459" "155.8" "153.6" "151.1" "166.7" "165.8" "137.2" "167.9" "165.7" "140.7" "227.3" "" "" "" "" "" "" "" "" "" "" "140.0" "124.3" "136.6" "162.7" "136.8" "137.2" "125.7" "146.4" "125.9" "81.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4393655725346314780" "False" "High" "IsMasterProtein" "Q8NHY2" "E3 ubiquitin-protein ligase COP1 OS=Homo sapiens OX=9606 GN=COP1 PE=1 SV=1" "0.000" "False" "5.988" "3" "2" "2" "2" "731" "80.4" "6.84" "6.31" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00400, Pf13923" "64326" "ENSG00000143207" "COP1" "E9PKI0; Q504W6; Q6H103; Q8NHY2; Q9H6L7; X5D9B4" "" "Neddylation; Autodegradation of the E3 ubiquitin ligase COP1" "2" "0" "1.089" "1.098" "1.112" "1.110" "1.421" "1.145" "1.130" "1.030" "1.033" "113.4" "123.6" "124.6" "126.1" "125.9" "161.2" "129.9" "128.2" "116.8" "117.1" "" "" "" "" "" "" "" "" "" "" "102.0" "100.0" "112.7" "123.1" "103.9" "161.2" "97.3" "113.3" "104.5" "41.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8624689202228352756" "False" "High" "IsMasterProtein" "Q8IWJ2" "GRIP and coiled-coil domain-containing protein 2 OS=Homo sapiens OX=9606 GN=GCC2 PE=1 SV=4" "0.000" "False" "5.986" "1" "3" "4" "2" "1684" "195.8" "5.14" "9.22" "3" "cell organization and biogenesis;transport;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf01465, Pf16704" "9648" "ENSG00000135968" "GCC2" "A6H8X8; hsa:9648; O15045; Q4ZG46; Q8IWJ2; Q8TDH3; Q9H2G8" "Deregulation of Rab and Rab effector genes in bladder cancer" "Retrograde transport at the Trans-Golgi-Network; Signaling by ALK fusions and activated point mutants" "3" "0" "0.945" "1.160" "0.725" "0.875" "0.751" "1.113" "1.102" "0.775" "0.966" "284.5" "268.9" "330.0" "206.3" "248.9" "213.7" "316.7" "313.4" "220.4" "274.8" "" "" "" "" "" "" "" "" "" "" "255.8" "217.6" "298.5" "201.4" "205.4" "213.7" "237.2" "276.8" "197.2" "98.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8139955916062878316" "False" "High" "IsMasterProtein" "Q9BZ95" "Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1" "0.000" "False" "5.969" "1" "2" "2" "2" "1437" "161.5" "8.21" "6.70" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00855, Pf00856, Pf17907, Pf17982" "54904" "ENSG00000147548" "NSD3" "B7ZL11; D3DSX1; hsa:54904; Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9BZ95; Q9H2M8; Q9H9W9; Q9NXA6" "" "PKMTs methylate histone lysines" "1" "0" "0.955" "0.851" "0.885" "0.930" "0.863" "1.000" "0.913" "0.781" "1.204" "105.0" "100.2" "89.4" "92.9" "97.6" "90.6" "105.0" "95.8" "82.0" "126.5" "" "" "" "" "" "" "" "" "" "" "94.4" "81.1" "80.8" "90.7" "80.6" "90.6" "78.6" "84.6" "73.4" "45.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6462604528965410945" "False" "High" "IsMasterProtein" "O15392" "Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3" "0.000" "False" "5.965" "16" "2" "2" "2" "142" "16.4" "5.90" "8.32" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00653" "332" "ENSG00000089685" "BIRC5" "A2SUH6; B2R4R1; hsa:332; O15392; Q2I3N8; Q4VGX0; Q53F61; Q5MGC6; Q6FHL2; Q75SP2; Q9P2W8" "Apoptosis modulation and signaling; Interleukin-11 signaling pathway; Apoptosis; Apoptosis-related network due to altered Notch3 in ovarian cancer; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Hepatitis C and hepatocellular carcinoma; VEGFA-VEGFR2 signaling; IL-4 signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Extracellular vesicles in the crosstalk of cardiac cells; Gastrin signaling pathway; Hepatitis B infection; HDAC6 interactions in the central nervous system" "Separation of Sister Chromatids; Neddylation; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; SUMOylation of DNA replication proteins; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Interleukin-4 and Interleukin-13 signaling; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain" "25" "0" "0.875" "0.754" "0.872" "0.979" "0.693" "1.005" "0.973" "0.648" "0.753" "329.7" "288.4" "248.6" "287.5" "322.8" "228.5" "331.4" "320.9" "213.6" "248.2" "" "" "" "" "" "" "" "" "" "" "296.4" "233.4" "224.9" "280.6" "266.4" "228.5" "248.1" "283.4" "191.1" "88.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4954031466942572679" "False" "High" "IsMasterProtein" "Q6NW29" "RWD domain-containing protein 4 OS=Homo sapiens OX=9606 GN=RWDD4 PE=1 SV=3" "0.000" "False" "5.964" "11" "2" "2" "2" "188" "21.2" "5.31" "6.64" "2" "" "" "" "Pf05773" "201965" "ENSG00000182552" "RWDD4" "B2RDE9; B4DDP2; hsa:201965; Q6NW29; Q75LA9; Q8WVW2" "" "" "0" "0" "0.950" "1.049" "1.064" "1.067" "1.068" "0.871" "1.057" "1.295" "1.838" "225.2" "214.0" "236.2" "239.5" "240.2" "240.6" "196.1" "238.0" "291.5" "413.9" "" "" "" "" "" "" "" "" "" "" "202.5" "173.2" "213.6" "233.8" "198.2" "240.6" "146.9" "210.3" "260.8" "147.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3146849743976844279" "False" "High" "IsMasterProtein" "Q02809" "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 OS=Homo sapiens OX=9606 GN=PLOD1 PE=1 SV=2" "0.000" "False" "5.963" "2" "2" "2" "1" "727" "83.5" "6.95" "6.55" "2" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf03171" "5351" "ENSG00000083444" "PLOD1" "B4DR87; hsa:5351; Q02809; Q96AV9; Q9H132" "Type I collagen synthesis in the context of osteogenesis imperfecta" "Collagen biosynthesis and modifying enzymes" "2" "0" "1.288" "1.130" "1.181" "1.189" "1.494" "1.364" "1.164" "1.740" "1.312" "89.5" "115.2" "101.1" "105.7" "106.4" "133.6" "122.0" "104.2" "155.6" "117.4" "" "" "" "" "" "" "" "" "" "" "80.4" "93.2" "91.4" "103.1" "87.8" "133.6" "91.4" "92.0" "139.3" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6981567354116466271" "False" "High" "IsMasterProtein" "O43542" "DNA repair protein XRCC3 OS=Homo sapiens OX=9606 GN=XRCC3 PE=1 SV=1" "0.000" "False" "5.958" "10" "3" "3" "3" "346" "37.8" "8.48" "7.58" "3" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7517" "ENSG00000126215" "XRCC3" "hsa:7517; O43542; O43568; Q9BU18" "Fluoropyrimidine activity; Male infertility" "Resolution of D-loop Structures through Holliday Junction Intermediates; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Homologous DNA Pairing and Strand Exchange" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2990327377986760395" "False" "High" "IsMasterProtein" "Q8N9Q2" "Protein SREK1IP1 OS=Homo sapiens OX=9606 GN=SREK1IP1 PE=1 SV=1" "0.000" "False" "5.954" "13" "2" "2" "2" "155" "18.2" "9.85" "6.18" "2" "RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf13917" "285672" "ENSG00000153006" "SREK1IP1" "hsa:285672; Q32NC8; Q8N9Q2" "" "" "0" "0" "1.170" "1.019" "1.093" "1.134" "1.090" "1.102" "1.149" "1.176" "1.210" "110.5" "129.2" "112.6" "120.7" "125.3" "120.4" "121.8" "126.9" "129.9" "133.7" "" "" "" "" "" "" "" "" "" "" "99.3" "104.5" "101.8" "117.8" "103.4" "120.4" "91.2" "112.1" "116.2" "47.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6530118680274496318" "False" "High" "IsMasterProtein" "Q9UHB7" "AF4/FMR2 family member 4 OS=Homo sapiens OX=9606 GN=AFF4 PE=1 SV=1" "0.000" "False" "5.952" "2" "2" "2" "2" "1163" "127.4" "9.31" "5.77" "2" "stress response;other biological processes" "nucleus;other cell component" "" "Pf05110, Pf18875, Pf18876" "27125" "ENSG00000072364" "AFF4" "B2RP19; B7WPD2; hsa:27125; Q498B2; Q59FB3; Q6P592; Q8TDR1; Q9P0E4; Q9UHB7" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "1.217" "1.048" "0.946" "0.936" "1.046" "0.983" "0.939" "0.869" "1.150" "120.1" "146.2" "125.8" "113.6" "112.4" "125.6" "118.0" "112.8" "104.3" "138.1" "" "" "" "" "" "" "" "" "" "" "108.0" "118.3" "113.8" "110.9" "92.8" "125.6" "88.3" "99.6" "93.4" "49.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4656669965841171391" "False" "High" "IsMasterProtein" "Q8NBQ5" "Estradiol 17-beta-dehydrogenase 11 OS=Homo sapiens OX=9606 GN=HSD17B11 PE=1 SV=4" "0.000" "False" "5.947" "9" "2" "2" "2" "300" "32.9" "9.17" "7.34" "2" "other metabolic processes" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00106" "51170" "ENSG00000198189" "HSD17B11" "hsa:51170; Q8NBQ5; Q96HF6; Q9UKU4" "" "Estrogen biosynthesis" "1" "0" "1.009" "0.920" "0.996" "1.086" "0.958" "0.904" "0.819" "0.991" "0.968" "45.5" "45.9" "41.9" "45.4" "49.4" "43.6" "41.2" "37.3" "45.1" "44.1" "" "" "" "" "" "" "" "" "" "" "41.0" "37.2" "37.9" "44.3" "40.8" "43.6" "30.8" "32.9" "40.4" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-559088974634696514" "False" "High" "IsMasterProtein" "P13598" "Intercellular adhesion molecule 2 OS=Homo sapiens OX=9606 GN=ICAM2 PE=1 SV=2" "0.000" "False" "5.939" "6" "2" "2" "2" "275" "30.6" "7.43" "6.90" "2" "cell adhesion" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf03921" "3384" "ENSG00000108622" "ICAM2" "hsa:3384; P13598; Q14600" "Complement system; Ebola virus infection in host" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions; CD209 (DC-SIGN) signaling" "5" "0" "0.875" "1.030" "0.993" "0.836" "0.929" "0.940" "0.879" "0.882" "0.652" "215.7" "188.7" "222.2" "214.1" "180.3" "200.3" "202.8" "189.5" "190.2" "140.6" "" "" "" "" "" "" "" "" "" "" "193.9" "152.7" "201.0" "209.0" "148.8" "200.3" "151.8" "167.4" "170.2" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1367538517643276436" "False" "High" "IsMasterProtein" "Q13724" "Mannosyl-oligosaccharide glucosidase OS=Homo sapiens OX=9606 GN=MOGS PE=1 SV=5" "0.000" "False" "5.924" "3" "2" "2" "2" "837" "91.9" "8.90" "7.03" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf03200, Pf16923" "7841" "ENSG00000115275" "MOGS" "A8K938; F5H6D0; hsa:7841; Q13724; Q17RN9; Q8TCT5" "N-glycan biosynthesis" "Maturation of spike protein; N-glycan trimming in the ER and Calnexin/Calreticulin cycle; Maturation of spike protein; Defective MOGS causes CDG-2b" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6403142608945012148" "False" "High" "IsMasterProtein" "Q8IX01" "SURP and G-patch domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SUGP2 PE=1 SV=2" "0.000" "False" "5.919" "2" "2" "2" "2" "1082" "120.1" "7.28" "5.91" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf01585, Pf01805" "10147" "ENSG00000064607" "SUGP2" "C9JI71; hsa:10147; O15071; O60369; Q5JPH7; Q8IX01; Q8WUF7" "mRNA processing" "" "1" "0" "0.991" "0.841" "0.996" "0.752" "0.954" "0.988" "0.847" "0.790" "2.796" "100.3" "99.4" "84.4" "100.0" "75.4" "95.7" "99.1" "84.9" "79.3" "280.5" "" "" "" "" "" "" "" "" "" "" "90.2" "80.5" "76.3" "97.6" "62.2" "95.7" "74.2" "75.0" "70.9" "100.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3309717020774859274" "False" "High" "IsMasterProtein" "Q96GQ7" "Probable ATP-dependent RNA helicase DDX27 OS=Homo sapiens OX=9606 GN=DDX27 PE=1 SV=2" "0.000" "False" "5.912" "2" "2" "2" "2" "796" "89.8" "9.28" "6.08" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00270, Pf00271" "55661" "" "DDX27" "A0AVB6; B7ZLY1; Q5VXM7; Q8WYG4; Q969N7; Q96F57; Q96GQ7; Q96L97; Q9BWY9; Q9BXF0; Q9H990; Q9NWU3; Q9P0C2; Q9UGD6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2186364449985292911" "False" "High" "IsMasterProtein" "P63172" "Dynein light chain Tctex-type 1 OS=Homo sapiens OX=9606 GN=DYNLT1 PE=1 SV=1" "0.000" "False" "5.881" "30" "2" "2" "2" "113" "12.4" "5.08" "5.93" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf03645" "6993" "ENSG00000146425" "DYNLT1" "hsa:6993; P63172; Q15763; Q5VTU4" "Ciliary landscape; Intraflagellar transport proteins binding to dynein; Genes related to primary cilium development (based on CRISPR); 3q29 copy number variation syndrome" "Neutrophil degranulation" "5" "0" "0.994" "0.951" "1.120" "0.993" "1.001" "0.968" "1.019" "1.123" "0.861" "202.3" "201.2" "192.4" "226.6" "200.8" "202.5" "195.9" "206.1" "227.2" "174.2" "" "" "" "" "" "" "" "" "" "" "181.9" "162.8" "174.0" "221.2" "165.7" "202.5" "146.7" "182.1" "203.3" "62.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6229699224070924638" "False" "High" "IsMasterProtein" "Q13107" "Ubiquitin carboxyl-terminal hydrolase 4 OS=Homo sapiens OX=9606 GN=USP4 PE=1 SV=3" "0.000" "False" "5.874" "2" "2" "3" "1" "963" "108.5" "5.71" "8.71" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00443, Pf06337, Pf14836" "7375" "ENSG00000114316" "USP4" "A8K6Y0; C9IY91; hsa:7375; O43452; O43453; Q08AK8; Q13107" "" "Ub-specific processing proteases; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "4" "0" "0.878" "0.748" "0.892" "0.784" "0.920" "0.898" "0.665" "0.947" "5.925" "97.6" "85.6" "73.0" "87.0" "76.5" "89.8" "87.6" "64.9" "92.4" "578.1" "" "" "" "" "" "" "" "" "" "" "87.7" "69.3" "66.0" "84.9" "63.1" "89.8" "65.6" "57.3" "82.7" "206.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8991968867262954800" "False" "High" "IsMasterProtein" "Q9P2K8" "eIF-2-alpha kinase GCN2 OS=Homo sapiens OX=9606 GN=EIF2AK4 PE=1 SV=3" "0.000" "False" "5.864" "2" "3" "3" "3" "1649" "186.8" "6.28" "5.14" "3" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf00069, Pf05773, Pf12745, Pf13393" "440275" "ENSG00000128829" "EIF2AK4" "C9JEC4; hsa:440275; Q69YL7; Q6DC97; Q96GN6; Q9H5K1; Q9NSQ3; Q9NSZ5; Q9P2K8; Q9UJ56" "Measles virus infection" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "2" "0" "1.233" "0.935" "0.954" "0.977" "0.954" "1.090" "0.929" "0.901" "1.210" "104.8" "129.2" "98.0" "99.9" "102.4" "99.9" "114.2" "97.3" "94.4" "126.7" "" "" "" "" "" "" "" "" "" "" "94.2" "104.5" "88.6" "97.5" "84.5" "99.9" "85.5" "86.0" "84.5" "45.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5543931740707389178" "False" "High" "IsMasterProtein" "Cont_Q28065" "C4b-binding protein alpha chain OS=Bos taurus OX=9913 GN=C4BPA PE=2 SV=1" "0.000" "True" "5.859" "4" "3" "3" "3" "610" "68.8" "6.38" "5.91" "3" "stress response;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "" "Pf00084, Pf18453" "281651" "ENSBIXG00000017034; ENSBTAG00000009876" "C4BPA; LOC113906358" "A0A4W2EK29; bta:281651; Q28065; Q2KJ87" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7054599493317546199" "False" "High" "IsMasterProtein" "Q8TCC3" "Large ribosomal subunit protein uL30m OS=Homo sapiens OX=9606 GN=MRPL30 PE=1 SV=1" "0.000" "False" "5.857" "13" "2" "2" "2" "161" "18.5" "9.99" "6.93" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00327" "51263" "ENSG00000185414" "MRPL30" "A6NIC6; D3DVI0; D3DVI3; hsa:51263; Q0D2Q7; Q6ZTP4; Q8TCC3; Q96Q69; Q9P0N0" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.013" "0.798" "0.955" "0.953" "0.863" "1.040" "0.892" "0.988" "0.915" "118.8" "120.3" "94.8" "113.5" "113.1" "102.4" "123.5" "105.9" "117.3" "108.6" "" "" "" "" "" "" "" "" "" "" "106.8" "97.4" "85.8" "110.8" "93.4" "102.4" "92.5" "93.5" "105.0" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7755566090060093643" "False" "High" "IsMasterProtein" "P35914" "Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=HMGCL PE=1 SV=2" "0.000" "False" "5.854" "6" "2" "2" "2" "325" "34.3" "8.54" "5.99" "2" "cell organization and biogenesis;other metabolic processes" "cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00682" "3155" "ENSG00000117305" "HMGCL" "B4DUP4; B7UCC6; D3Y5K7; hsa:3155; P35914; Q6IBC0; Q96FP8" "Amino acid metabolism" "Peroxisomal protein import; Synthesis of Ketone Bodies" "3" "0" "1.071" "1.098" "1.010" "1.093" "1.065" "1.060" "0.991" "1.123" "0.751" "126.5" "135.5" "138.9" "127.7" "138.2" "134.7" "134.1" "125.3" "142.0" "95.0" "" "" "" "" "" "" "" "" "" "" "113.7" "109.6" "125.6" "124.7" "114.1" "134.7" "100.4" "110.7" "127.1" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4879216047058048587" "False" "High" "IsMasterProtein" "P81605" "Dermcidin OS=Homo sapiens OX=9606 GN=DCD PE=1 SV=2" "0.000" "False" "5.848" "23" "3" "3" "3" "110" "11.3" "6.54" "4.42" "3" "protein metabolism;stress response;transport" "non-structural extracellular;other membranes" "transporter activity;other molecular function" "Pf15291" "117159" "ENSG00000161634" "DCD" "A5JHP2; A5JHP3; hsa:117159; P58461; P81605; Q53YJ2" "" "Antimicrobial peptides" "1" "0" "0.364" "0.444" "0.402" "0.438" "0.290" "0.440" "0.426" "0.404" "0.237" "278.8" "101.5" "123.7" "112.2" "122.1" "80.9" "122.7" "118.9" "112.7" "66.1" "" "" "" "" "" "" "" "" "" "" "250.7" "82.1" "111.9" "109.5" "100.8" "80.9" "91.9" "105.0" "100.8" "23.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3946386613732823747" "False" "High" "IsMasterProtein" "Q8WXD5" "Gem-associated protein 6 OS=Homo sapiens OX=9606 GN=GEMIN6 PE=1 SV=1" "0.000" "False" "5.846" "14" "2" "3" "2" "167" "18.8" "5.12" "10.28" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf06372, Pf20417" "79833" "ENSG00000152147" "GEMIN6" "B2RDP8; hsa:79833; Q53SI5; Q8WVB4; Q8WXD5; Q9H5G6" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "0.968" "0.837" "0.965" "0.975" "0.941" "1.083" "0.849" "0.817" "1.530" "148.7" "144.1" "124.5" "143.6" "145.0" "139.9" "161.1" "126.2" "121.5" "227.6" "" "" "" "" "" "" "" "" "" "" "133.7" "116.6" "112.7" "140.2" "119.7" "139.9" "120.6" "111.5" "108.7" "81.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1000021269069197599" "False" "High" "IsMasterProtein" "Q9Y5V3" "Melanoma-associated antigen D1 OS=Homo sapiens OX=9606 GN=MAGED1 PE=1 SV=3" "0.000" "False" "5.842" "3" "2" "2" "2" "778" "86.1" "5.83" "7.83" "2" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01454" "9500" "ENSG00000179222" "MAGED1" "hsa:9500; Q5VSH6; Q8IZ84; Q8WY92; Q9H352; Q9HBT4; Q9UF36; Q9Y5V3" "5q35 copy number variation" "NRAGE signals death through JNK; Caspase activation via Dependence Receptors in the absence of ligand" "3" "0" "0.908" "0.998" "0.936" "0.976" "1.112" "0.897" "0.876" "1.185" "1.136" "100.5" "91.2" "100.3" "94.1" "98.1" "111.8" "90.1" "88.0" "119.1" "114.2" "" "" "" "" "" "" "" "" "" "" "90.4" "73.8" "90.7" "91.8" "81.0" "111.8" "67.5" "77.7" "106.6" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4328558024401800768" "False" "High" "IsMasterProtein" "Q12913" "Receptor-type tyrosine-protein phosphatase eta OS=Homo sapiens OX=9606 GN=PTPRJ PE=1 SV=3" "0.000" "False" "5.831" "1" "2" "2" "2" "1337" "145.9" "5.58" "6.87" "2" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf00102, Pf18861" "5795" "ENSG00000149177" "PTPRJ" "hsa:5795; Q12913; Q15255; Q6P4H4; Q8NHM2; Q9UDA9" "VEGFA-VEGFR2 signaling" "Neutrophil degranulation; Phosphorylation of CD3 and TCR zeta chains; Negative regulation of FLT3; Negative regulation of MET activity" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4482584710342815386" "False" "High" "IsMasterProtein" "Q15773" "Myeloid leukemia factor 2 OS=Homo sapiens OX=9606 GN=MLF2 PE=1 SV=1" "0.000" "False" "5.829" "8" "2" "2" "2" "248" "28.1" "6.90" "6.00" "2" "other biological processes" "nucleus;other cell component" "" "Pf10248" "8079" "ENSG00000089693" "MLF2" "hsa:8079; Q15773" "" "" "0" "0" "1.089" "1.163" "0.942" "1.121" "1.089" "1.107" "1.032" "1.181" "3.226" "205.1" "223.3" "238.5" "193.2" "229.9" "223.4" "226.9" "211.7" "242.2" "661.4" "" "" "" "" "" "" "" "" "" "" "184.4" "180.7" "215.8" "188.6" "189.7" "223.4" "169.9" "187.0" "216.7" "236.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5457193127181059495" "False" "High" "IsMasterProtein" "Q8TDR0" "TRAF3-interacting protein 1 OS=Homo sapiens OX=9606 GN=TRAF3IP1 PE=1 SV=1" "0.000" "False" "5.827" "3" "2" "2" "2" "691" "78.6" "7.93" "6.69" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf10243, Pf17749" "26146" "ENSG00000204104" "TRAF3IP1" "hsa:26146; Q6PCT1; Q7L8N9; Q8TDR0; Q9NRD6; Q9Y4Q1" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Ciliopathies; 2q37 copy number variation syndrome; Bardet-Biedl syndrome" "Intraflagellar transport" "6" "0" "0.990" "1.022" "0.765" "1.088" "1.093" "0.994" "0.837" "1.043" "1.032" "70.4" "69.7" "71.9" "53.9" "76.6" "76.9" "70.0" "58.9" "73.4" "72.7" "" "" "" "" "" "" "" "" "" "" "63.3" "56.4" "65.1" "52.6" "63.2" "76.9" "52.4" "52.0" "65.7" "25.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1301679656055029716" "False" "High" "IsMasterProtein" "Q9BWG6" "Sodium channel modifier 1 OS=Homo sapiens OX=9606 GN=SCNM1 PE=1 SV=1" "0.000" "False" "5.814" "12" "2" "2" "2" "230" "25.9" "8.87" "4.96" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15803, Pf15805" "100534012; 79005" "ENSG00000163156" "SCNM1" "B4DWR1; hsa:100534012; hsa:79005; Q5JR74; Q9BWG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5468986810261152963" "False" "High" "IsMasterProtein" "Q15334" "Lethal(2) giant larvae protein homolog 1 OS=Homo sapiens OX=9606 GN=LLGL1 PE=1 SV=3" "0.000" "False" "5.811" "2" "2" "2" "2" "1064" "115.3" "6.29" "6.00" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf08366" "3996" "ENSG00000131899" "LLGL1" "A7MBM7; hsa:3996; O00188; Q15334; Q58F11; Q86UK6" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "0.879" "0.956" "0.838" "0.928" "0.960" "0.986" "0.979" "0.942" "0.952" "92.8" "81.6" "88.7" "77.8" "86.0" "89.0" "91.4" "90.8" "87.4" "88.3" "" "" "" "" "" "" "" "" "" "" "83.4" "66.0" "80.2" "75.9" "71.0" "89.0" "68.5" "80.2" "78.2" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4633988099481439098" "False" "High" "IsMasterProtein" "Q9Y5T5" "Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens OX=9606 GN=USP16 PE=1 SV=1" "0.000" "False" "5.806" "3" "2" "2" "2" "823" "93.5" "6.93" "2.80" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf00443, Pf02148" "10600" "ENSG00000156256; ENSG00000291527" "USP16" "A8MU43; B3KN13; B4DFV8; B4DY37; D3DSD9; hsa:10600; Q53GP7; Q53HA0; Q5VKN8; Q8NEL3; Q9H3E6; Q9Y5T5" "" "Ub-specific processing proteases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3800071337117646990" "False" "High" "IsMasterProtein" "Q92738" "USP6 N-terminal-like protein OS=Homo sapiens OX=9606 GN=USP6NL PE=1 SV=3" "0.000" "False" "5.801" "3" "2" "2" "2" "828" "94.0" "9.07" "3.24" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00566" "9712" "ENSG00000148429" "USP6NL" "A8KA79; hsa:9712; Q15400; Q5VV10; Q7L0K9; Q92738" "EGF/EGFR signaling pathway" "Retrograde transport at the Trans-Golgi-Network" "2" "0" "1.018" "1.059" "0.865" "0.929" "0.972" "0.825" "0.909" "0.980" "1.022" "29.9" "30.5" "31.7" "25.9" "27.8" "29.1" "24.7" "27.2" "29.3" "30.6" "" "" "" "" "" "" "" "" "" "" "26.9" "24.7" "28.7" "25.3" "22.9" "29.1" "18.5" "24.0" "26.2" "10.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4513402261466963400" "False" "High" "IsMasterProtein" "O75582" "Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens OX=9606 GN=RPS6KA5 PE=1 SV=1" "0.000" "False" "5.796" "2" "2" "2" "2" "802" "89.8" "7.11" "5.58" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00433" "9252" "ENSG00000100784" "RPS6KA5" "B7Z2Y5; hsa:9252; O75582; O95316; Q96AF7" "Brain-derived neurotrophic factor (BDNF) signaling pathway; Interleukin-1 (IL-1) structural pathway; Bladder cancer; MAPK signaling pathway; ERK pathway in Huntington's disease; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; p38 MAPK signaling pathway; EGF/EGFR signaling pathway; Translation inhibitors in chronically activated PDGFRA cells; Insulin signaling; Pleural mesothelioma; Hippocampal synaptogenesis and neurogenesis; Macrophage-stimulating protein (MSP) signaling network map; Interferon type I signaling pathways; Serotonin HTR1 group and FOS pathway; Serotonin receptor 4/6/7 and NR3C signaling" "Recycling pathway of L1; NCAM signaling for neurite out-growth; ERK/MAPK targets; CREB phosphorylation; CD209 (DC-SIGN) signaling" "22" "0" "1.069" "1.056" "0.912" "1.055" "1.059" "1.126" "0.947" "0.901" "2.567" "49.0" "52.4" "51.8" "44.7" "51.7" "51.9" "55.2" "46.5" "44.2" "125.9" "" "" "" "" "" "" "" "" "" "" "44.1" "42.4" "46.8" "43.7" "42.7" "51.9" "41.3" "41.0" "39.5" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4942654517427891889" "False" "High" "IsMasterProtein" "Q9H6D7" "HAUS augmin-like complex subunit 4 OS=Homo sapiens OX=9606 GN=HAUS4 PE=1 SV=1" "0.000" "False" "5.795" "7" "2" "2" "2" "363" "42.4" "5.68" "7.07" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf14735" "54930" "ENSG00000092036" "HAUS4" "B7WP17; D3DS34; hsa:54930; Q86T15; Q86T16; Q86U43; Q9H6D7; Q9NX59" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.003" "1.065" "1.060" "1.024" "1.053" "0.936" "0.965" "1.068" "2.072" "92.8" "93.1" "98.8" "98.3" "95.0" "97.7" "86.9" "89.5" "99.1" "192.2" "" "" "" "" "" "" "" "" "" "" "83.4" "75.3" "89.3" "96.0" "78.4" "97.7" "65.0" "79.0" "88.7" "68.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841381739766448706" "False" "High" "IsMasterProtein" "Q2M296" "Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens OX=9606 GN=MTHFSD PE=1 SV=2" "0.000" "False" "5.793" "8" "4" "4" "4" "383" "42.1" "8.73" "9.93" "4" "" "other cell component" "" "Pf00076, Pf01812" "64779" "ENSG00000103248" "MTHFSD" "A8MQ77; B7ZLC0; B7ZLC2; D3DUM9; E9PAM1; hsa:64779; Q2M296; Q9H878; Q9H954" "" "" "0" "0" "0.976" "0.984" "0.893" "0.953" "0.943" "0.969" "0.938" "0.879" "0.865" "293.1" "286.2" "288.4" "261.8" "279.3" "276.4" "284.0" "274.8" "257.7" "253.6" "" "" "" "" "" "" "" "" "" "" "263.5" "231.6" "260.8" "255.5" "230.5" "276.4" "212.6" "242.7" "230.6" "90.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3915104900764818222" "False" "High" "IsMasterProtein" "Q86TG7" "Retrotransposon-derived protein PEG10 OS=Homo sapiens OX=9606 GN=PEG10 PE=1 SV=2" "0.000" "False" "5.793" "2" "2" "2" "2" "708" "80.1" "6.39" "6.54" "2" "cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf16297" "23089" "ENSG00000242265" "PEG10" "B4DSP0; hsa:23089; Q86TG7; Q96A68; Q9UPV1" "" "" "0" "0" "1.042" "0.906" "0.849" "0.939" "0.945" "0.971" "0.860" "0.863" "3.415" "250.3" "260.9" "226.6" "212.6" "235.1" "236.5" "242.9" "215.2" "215.9" "854.7" "" "" "" "" "" "" "" "" "" "" "225.0" "211.1" "205.0" "207.5" "194.0" "236.5" "181.9" "190.1" "193.2" "305.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-699838257049576232" "False" "High" "IsMasterProtein" "Q8IWC1" "MAP7 domain-containing protein 3 OS=Homo sapiens OX=9606 GN=MAP7D3 PE=1 SV=2" "0.000" "False" "5.765" "3" "3" "3" "3" "876" "98.4" "9.32" "8.60" "3" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf05672" "79649" "ENSG00000129680" "MAP7D3" "A2A2J0; A6NCZ7; A6NHR4; B4DWD2; H7BY77; hsa:79649; Q5JXI5; Q5JXI6; Q6P2S1; Q8IWC1; Q9H9M8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9022447495493908816" "False" "High" "IsMasterProtein" "O75381" "Peroxisomal membrane protein PEX14 OS=Homo sapiens OX=9606 GN=PEX14 PE=1 SV=1" "0.000" "False" "5.754" "6" "2" "2" "2" "377" "41.2" "4.94" "3.39" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;cytoskeletal activity;other molecular function" "Pf04695" "5195" "ENSG00000142655" "PEX14" "B2R7N1; B3KML6; B7Z1N2; hsa:5195; O75381; Q8WX51" "" "E3 ubiquitin ligases ubiquitinate target proteins; Peroxisomal protein import; Class I peroxisomal membrane protein import" "3" "0" "1.136" "0.996" "1.098" "1.009" "0.979" "1.271" "1.193" "1.025" "0.949" "102.8" "116.8" "102.4" "112.8" "103.7" "100.6" "130.6" "122.6" "105.3" "97.6" "" "" "" "" "" "" "" "" "" "" "92.4" "94.5" "92.6" "110.1" "85.6" "100.6" "97.8" "108.3" "94.2" "34.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4827521234037792457" "False" "High" "IsMasterProtein" "Q9NUS5" "AP-5 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP5S1 PE=1 SV=1" "0.000" "False" "5.752" "9" "2" "2" "1" "200" "22.5" "6.87" "6.73" "2" "DNA metabolism;stress response;transport" "other membranes;cytosol;nucleus;other cytoplasmic organelle" "" "Pf15001" "55317" "ENSG00000125843" "AP5S1" "B3KSD0; D3DVY7; hsa:55317; Q9NUS5" "" "" "0" "0" "0.951" "1.130" "0.941" "1.097" "1.044" "1.139" "1.001" "1.101" "1.954" "66.4" "63.2" "75.0" "62.5" "72.8" "69.3" "75.7" "66.5" "73.2" "129.8" "" "" "" "" "" "" "" "" "" "" "59.7" "51.1" "67.9" "61.0" "60.1" "69.3" "56.7" "58.7" "65.5" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "859606760973151215" "False" "High" "IsMasterProtein" "Q562F6" "Shugoshin 2 OS=Homo sapiens OX=9606 GN=SGO2 PE=1 SV=2" "0.000" "False" "5.741" "2" "2" "3" "2" "1265" "144.7" "7.91" "11.25" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "" "" "151246" "ENSG00000163535" "SGO2" "hsa:151246; Q53RR9; Q53T20; Q562F6; Q86XY4; Q8IWK2; Q8IZK1; Q8N1Q5; Q96LQ3" "Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "1.204" "1.088" "1.210" "0.953" "1.067" "1.050" "0.995" "1.249" "0.854" "17.8" "21.4" "19.3" "21.5" "16.9" "19.0" "18.7" "17.7" "22.2" "15.2" "" "" "" "" "" "" "" "" "" "" "16.0" "17.3" "17.5" "21.0" "14.0" "19.0" "14.0" "15.6" "19.9" "5.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9003669345530149661" "False" "High" "IsMasterProtein" "Q15738" "Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating OS=Homo sapiens OX=9606 GN=NSDHL PE=1 SV=2" "0.000" "False" "5.740" "8" "2" "2" "2" "373" "41.9" "8.06" "5.61" "2" "other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01073" "50814" "ENSG00000147383; ENSG00000292192" "NSDHL" "D3DWT6; hsa:50814; O00344; Q15738" "Cholesterol biosynthesis pathway; Cholesterol metabolism with Bloch and Kandutsch-Russell pathways; Cholesterol biosynthesis with skeletal dysplasias; Cholesterol metabolism; Cholesterol biosynthesis pathway in hepatocytes; Enterocyte cholesterol metabolism" "Cholesterol biosynthesis" "7" "0" "0.954" "1.035" "0.969" "1.104" "1.060" "1.112" "0.949" "1.024" "1.013" "100.2" "95.7" "103.7" "97.1" "110.6" "106.3" "111.4" "95.1" "102.7" "101.5" "" "" "" "" "" "" "" "" "" "" "90.1" "77.4" "93.8" "94.8" "91.3" "106.3" "83.4" "84.0" "91.9" "36.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8568450672967987050" "False" "High" "IsMasterProtein" "Q9NWX5" "Ankyrin repeat and SOCS box protein 6 OS=Homo sapiens OX=9606 GN=ASB6 PE=1 SV=1" "0.000" "False" "5.727" "4" "2" "2" "2" "421" "47.1" "6.01" "7.37" "2" "protein metabolism;other metabolic processes;signal transduction" "cytosol" "" "Pf07525, Pf12796, Pf13637" "140459" "ENSG00000148331" "ASB6" "hsa:140459; Q5SZB7; Q9BV15; Q9NWX5" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "1.071" "1.069" "0.947" "1.024" "1.073" "0.982" "0.997" "1.091" "1.035" "339.4" "363.7" "363.0" "321.5" "347.7" "364.3" "333.4" "338.4" "370.3" "351.5" "" "" "" "" "" "" "" "" "" "" "305.2" "294.3" "328.3" "313.9" "286.9" "364.3" "249.7" "298.9" "331.4" "125.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8041398226355410347" "False" "High" "IsMasterProtein" "Q9NUL5" "Shiftless antiviral inhibitor of ribosomal frameshifting protein OS=Homo sapiens OX=9606 GN=SHFL PE=1 SV=2" "0.000" "False" "5.720" "6" "2" "3" "2" "291" "33.1" "7.25" "9.60" "2" "stress response;other biological processes" "cytosol;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf15135" "55337" "ENSG00000130813" "SHFL" "A8MQT9; hsa:55337; Q4G188; Q8IYH6; Q8N8V1; Q9NUL5" "" "" "0" "0" "1.156" "1.117" "0.911" "1.059" "1.162" "1.223" "1.218" "1.150" "0.945" "160.9" "185.9" "179.7" "146.5" "170.4" "186.9" "196.7" "196.0" "185.0" "152.0" "" "" "" "" "" "" "" "" "" "" "144.6" "150.5" "162.6" "143.0" "140.6" "186.9" "147.2" "173.1" "165.5" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8287217106573217655" "False" "High" "IsMasterProtein" "Q92540" "Nonsense-mediated mRNA decay factor SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2" "0.000" "False" "5.714" "2" "2" "2" "2" "1137" "127.2" "8.72" "6.31" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374" "9887" "ENSG00000116698" "SMG7" "B4DRB2; E9PCI0; E9PEH2; hsa:9887; Q5T1Q0; Q6PIE0; Q7Z7H9; Q8IXC1; Q8IXC2; Q92540" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "0.921" "1.014" "0.912" "0.877" "0.917" "1.130" "0.964" "0.804" "1.268" "170.7" "157.3" "173.1" "155.6" "149.7" "156.5" "192.9" "164.6" "137.2" "216.4" "" "" "" "" "" "" "" "" "" "" "153.5" "127.2" "156.5" "151.9" "123.5" "156.5" "144.5" "145.3" "122.8" "77.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5356440792729817096" "False" "High" "IsMasterProtein" "Q5VZ89" "DENN domain-containing protein 4C OS=Homo sapiens OX=9606 GN=DENND4C PE=1 SV=3" "0.000" "False" "5.708" "1" "2" "2" "2" "1909" "212.6" "6.83" "6.05" "2" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity" "Pf02141, Pf03455, Pf03456" "55667" "ENSG00000137145" "DENND4C" "A2A3R1; A2A3R2; A2A3R3; A2A3R9; hsa:55667; Q5VZ89; Q6AI48; Q6ZUB3; Q8NCY7; Q9H6N4; Q9NUT1; Q9NWA5; Q9NWT3; R4GN35; R4GNB2" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5057287332675180047" "False" "High" "IsMasterProtein" "P25963" "NF-kappa-B inhibitor alpha OS=Homo sapiens OX=9606 GN=NFKBIA PE=1 SV=1" "0.000" "False" "5.705" "5" "2" "3" "2" "317" "35.6" "4.68" "7.74" "2" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00023" "4792" "ENSG00000100906" "NFKBIA" "B2R8L6; hsa:4792; P25963" "Nucleotide-binding oligomerization domain (NOD) pathway; IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Prolactin signaling pathway; Thymic stromal lymphopoietin (TSLP) signaling pathway; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Quercetin and Nf-kB / AP-1 induced apoptosis; Apoptosis; Ebstein-Barr virus LMP1 signaling; RAC1/PAK1/p38/MMP2 pathway; Initiation of transcription and translation elongation at the HIV-1 LTR; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Chemokine signaling pathway; IL-4 signaling pathway; miRNA regulation of prostate cancer signaling pathways; NO/cGMP/PKG mediated neuroprotection; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Burn wound healing; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; GDNF signaling; 2q37 copy number variation syndrome; Comprehensive IL-17A signaling; IL-26 signaling pathways; Affected pathways in Duchenne muscular dystrophy; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; CLEC7A (Dectin-1) signaling; Ub-specific processing proteases; RIP-mediated NFkB activation via ZBP1; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; IkBA variant leads to EDA-ID; TRAF6 mediated NF-kB activation; SARS-CoV-1 activates/modulates innate immune responses; SUMOylation of immune response proteins" "63" "0" "0.986" "0.809" "0.977" "1.167" "0.779" "1.090" "1.004" "0.796" "1.759" "369.8" "364.5" "299.0" "361.1" "431.5" "288.0" "403.1" "371.2" "294.3" "650.4" "" "" "" "" "" "" "" "" "" "" "332.5" "294.9" "270.5" "352.5" "356.1" "288.0" "301.9" "327.9" "263.3" "232.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "809495191273134722" "False" "High" "IsMasterProtein" "P42356" "Phosphatidylinositol 4-kinase alpha OS=Homo sapiens OX=9606 GN=PI4KA PE=1 SV=4" "0.000" "False" "5.695" "1" "2" "2" "2" "2102" "236.7" "7.06" "4.72" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "kinase activity;other molecular function" "Pf00454, Pf00613, Pf19274" "5297" "ENSG00000241973" "PI4KA" "hsa:5297; P42356; Q7Z625; Q9UPG2" "Ectoderm differentiation; 22q11.2 copy number variation syndrome" "Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the ER membrane" "4" "0" "1.049" "1.074" "0.821" "1.128" "1.064" "1.228" "0.975" "1.036" "1.149" "162.2" "170.1" "174.2" "133.1" "183.0" "172.5" "199.2" "158.2" "168.0" "186.4" "" "" "" "" "" "" "" "" "" "" "145.8" "137.6" "157.6" "129.9" "151.0" "172.5" "149.1" "139.7" "150.3" "66.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3754382258737944185" "False" "High" "IsMasterProtein" "Q9Y546" "Leucine-rich repeat-containing protein 42 OS=Homo sapiens OX=9606 GN=LRRC42 PE=1 SV=1" "0.000" "False" "5.692" "4" "2" "2" "2" "428" "48.5" "7.46" "5.40" "2" "" "" "" "Pf13516" "115353" "ENSG00000116212" "LRRC42" "D3DQ46; hsa:115353; Q8N2Q8; Q9Y546" "" "" "0" "0" "0.896" "0.651" "0.635" "0.882" "0.900" "0.800" "0.732" "1.025" "1.027" "30.4" "27.2" "19.8" "19.3" "26.8" "27.3" "24.3" "22.2" "31.1" "31.2" "" "" "" "" "" "" "" "" "" "" "27.3" "22.0" "17.9" "18.8" "22.1" "27.3" "18.2" "19.6" "27.8" "11.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5800402154155294758" "False" "High" "IsMasterProtein" "Q8N300" "Small vasohibin-binding protein OS=Homo sapiens OX=9606 GN=SVBP PE=1 SV=1" "0.000" "False" "5.690" "33" "2" "2" "2" "66" "7.8" "9.16" "7.77" "2" "cell organization and biogenesis;protein metabolism;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf15674" "374969" "ENSG00000177868" "SVBP" "A8K5P1; D3DPW7; hsa:374969; Q8N300" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.150" "1.166" "0.961" "1.011" "1.257" "1.165" "1.070" "1.100" "0.895" "348.8" "401.0" "406.7" "335.3" "352.6" "438.6" "406.2" "373.2" "383.5" "312.1" "" "" "" "" "" "" "" "" "" "" "313.6" "324.5" "367.9" "327.3" "291.0" "438.6" "304.2" "329.6" "343.2" "111.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1508097308804950005" "False" "High" "IsMasterProtein" "Q9NRP2" "COX assembly mitochondrial protein 2 homolog OS=Homo sapiens OX=9606 GN=CMC2 PE=1 SV=1" "0.000" "False" "5.685" "25" "2" "2" "2" "79" "9.5" "7.87" "6.74" "2" "" "mitochondrion" "" "Pf08583" "56942" "ENSG00000103121; ENSG00000291948" "CMC2" "D3DUK6; hsa:56942; Q9NRP2" "" "Mitochondrial protein import" "1" "0" "0.940" "1.013" "0.925" "0.862" "1.153" "0.983" "1.022" "1.011" "0.970" "132.7" "124.8" "134.4" "122.8" "114.4" "153.0" "130.4" "135.6" "134.2" "128.7" "" "" "" "" "" "" "" "" "" "" "119.3" "101.0" "121.6" "119.9" "94.4" "153.0" "97.7" "119.8" "120.1" "45.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4949581647878709913" "False" "High" "IsMasterProtein" "Q7Z7A1" "Centriolin OS=Homo sapiens OX=9606 GN=CNTRL PE=1 SV=2" "0.000" "False" "5.671" "1" "3" "3" "2" "2325" "268.7" "5.55" "4.55" "3" "cell cycle OR cell proliferation;developmental processes;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf14580" "11064" "ENSG00000119397" "CNTRL" "A2A2Y1; B2RP67; hsa:11064; Q3MN79; Q5FWF8; Q5JVD0; Q6MZR3; Q6PKC1; Q7Z7A1; Q8TEP3; Q9Y489" "" "Anchoring of the basal body to the plasma membrane; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; AURKA Activation by TPX2" "7" "0" "0.891" "0.949" "0.988" "0.939" "1.015" "1.048" "1.062" "0.926" "0.707" "127.0" "113.1" "120.5" "125.4" "119.2" "128.9" "133.1" "134.8" "117.7" "89.8" "" "" "" "" "" "" "" "" "" "" "114.2" "91.6" "109.0" "122.5" "98.4" "128.9" "99.7" "119.1" "105.3" "32.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7629831506614287225" "False" "High" "IsMasterProtein" "Q96A47" "Insulin gene enhancer protein ISL-2 OS=Homo sapiens OX=9606 GN=ISL2 PE=1 SV=1" "0.000" "False" "5.662" "4" "2" "2" "2" "359" "39.7" "8.28" "4.99" "2" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00412" "64843" "ENSG00000159556" "ISL2" "B3KM37; hsa:64843; Q96A47" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7500811780682688662" "False" "High" "IsMasterProtein" "Q8N8S7" "Protein enabled homolog OS=Homo sapiens OX=9606 GN=ENAH PE=1 SV=2" "0.000" "False" "5.642" "3" "2" "3" "1" "591" "66.5" "6.93" "7.38" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00568, Pf08776" "55740" "ENSG00000154380" "ENAH" "D0PQI2; hsa:55740; Q502W5; Q5T5M7; Q5VTQ9; Q5VTR0; Q8N8S7; Q9NVF3; Q9UFB8" "Regulation of actin cytoskeleton" "Generation of second messenger molecules; Signaling by ROBO receptors" "3" "0" "0.919" "1.053" "1.009" "0.905" "1.103" "0.939" "1.184" "1.292" "0.636" "19.2" "17.6" "20.2" "19.4" "17.4" "21.2" "18.0" "22.7" "24.8" "12.2" "" "" "" "" "" "" "" "" "" "" "17.2" "14.3" "18.3" "18.9" "14.3" "21.2" "13.5" "20.1" "22.2" "4.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8757079958512544915" "False" "High" "IsMasterProtein" "Q96DE5" "Anaphase-promoting complex subunit 16 OS=Homo sapiens OX=9606 GN=ANAPC16 PE=1 SV=1" "0.000" "False" "5.639" "17" "2" "2" "2" "110" "11.7" "4.97" "7.57" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf17256" "119504" "ENSG00000166295" "ANAPC16" "hsa:119504; Q96DE5" "" "Separation of Sister Chromatids; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; CDK-mediated phosphorylation and removal of Cdc6; Autodegradation of Cdh1 by Cdh1:APC/C; Assembly of the pre-replicative complex; Inactivation of APC/C via direct inhibition of the APC/C complex; APC/C:Cdc20 mediated degradation of Cyclin B; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase; Regulation of APC/C activators between G1/S and early anaphase; Phosphorylation of the APC/C; APC-Cdc20 mediated degradation of Nek2A; Senescence-Associated Secretory Phenotype (SASP); Transcriptional Regulation by VENTX; Aberrant regulation of mitotic exit in cancer due to RB1 defects" "17" "0" "0.861" "0.835" "0.711" "0.824" "0.865" "0.846" "0.933" "0.832" "0.797" "104.9" "90.3" "87.6" "74.5" "86.5" "90.8" "88.7" "97.8" "87.3" "83.6" "" "" "" "" "" "" "" "" "" "" "94.3" "73.1" "79.2" "72.8" "71.4" "90.8" "66.4" "86.4" "78.1" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5948729275611586048" "False" "High" "IsMasterProtein" "Q70IA6" "MOB kinase activator 2 OS=Homo sapiens OX=9606 GN=MOB2 PE=1 SV=1" "0.000" "False" "5.632" "8" "2" "2" "2" "237" "26.9" "6.79" "7.36" "2" "signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03637" "81532" "ENSG00000182208; ENSG00000291442" "MOB2" "B4DKP3; hsa:81532; Q70IA6; Q96M67" "" "" "0" "0" "0.941" "0.966" "1.018" "1.042" "0.894" "1.076" "0.955" "0.925" "1.517" "456.6" "429.8" "440.9" "464.9" "475.7" "408.0" "491.5" "435.9" "422.3" "692.5" "" "" "" "" "" "" "" "" "" "" "410.5" "347.7" "398.8" "453.8" "392.6" "408.0" "368.0" "385.0" "377.9" "247.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8804712893716096184" "False" "High" "IsMasterProtein" "Q96S66" "Chloride channel CLIC-like protein 1 OS=Homo sapiens OX=9606 GN=CLCC1 PE=1 SV=1" "0.000" "False" "5.631" "5" "2" "2" "2" "551" "62.0" "5.55" "5.31" "2" "transport" "other membranes;ER/Golgi;nucleus;other cell component" "transporter activity" "Pf05934" "23155" "ENSG00000121940" "CLCC1" "hsa:23155; O94861; Q8WYP8; Q8WYP9; Q96S66; Q9BU25" "" "" "0" "0" "1.015" "1.074" "0.899" "1.185" "1.055" "1.387" "0.959" "0.865" "0.761" "83.0" "84.2" "89.1" "74.6" "98.3" "87.5" "115.1" "79.6" "71.8" "63.2" "" "" "" "" "" "" "" "" "" "" "74.6" "68.1" "80.6" "72.8" "81.1" "87.5" "86.2" "70.3" "64.2" "22.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1820553366353762966" "False" "High" "IsMasterProtein" "Q9UKF7" "Cytoplasmic phosphatidylinositol transfer protein 1 OS=Homo sapiens OX=9606 GN=PITPNC1 PE=1 SV=3" "0.000" "False" "5.631" "7" "2" "2" "2" "332" "38.4" "6.40" "5.61" "2" "cell organization and biogenesis;transport;signal transduction" "cytosol;nucleus;other cell component" "transporter activity;other molecular function" "Pf02121" "26207" "ENSG00000154217" "PITPNC1" "A8K473; hsa:26207; J3QR20; Q96I07; Q9UKF7" "" "" "0" "0" "1.395" "1.266" "1.095" "1.196" "0.880" "0.744" "1.445" "1.108" "0.857" "22.2" "31.0" "28.1" "24.3" "26.6" "19.6" "16.5" "32.1" "24.6" "19.0" "" "" "" "" "" "" "" "" "" "" "20.0" "25.1" "25.4" "23.7" "21.9" "19.6" "12.4" "28.4" "22.0" "6.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4549046662216953457" "False" "High" "IsMasterProtein" "Q86XN7" "Proline and serine-rich protein 1 OS=Homo sapiens OX=9606 GN=PROSER1 PE=1 SV=2" "0.000" "False" "5.618" "2" "2" "2" "2" "944" "95.6" "8.88" "5.40" "2" "" "" "" "Pf14771" "80209" "ENSG00000120685" "PROSER1" "A6NJ97; hsa:80209; Q6P2S2; Q7Z3X5; Q86XN7; Q8N3D2; Q8N3P1; Q9H9M1" "" "" "0" "0" "1.039" "0.914" "1.056" "1.039" "0.984" "1.063" "1.137" "0.919" "1.445" "69.8" "72.6" "63.8" "73.7" "72.6" "68.7" "74.2" "79.4" "64.1" "100.9" "" "" "" "" "" "" "" "" "" "" "62.8" "58.7" "57.7" "71.9" "59.9" "68.7" "55.5" "70.1" "57.4" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-476586099519423561" "False" "High" "IsMasterProtein" "Q9UI43" "rRNA methyltransferase 2, mitochondrial OS=Homo sapiens OX=9606 GN=MRM2 PE=1 SV=1" "0.000" "False" "5.615" "7" "2" "3" "2" "246" "27.4" "9.50" "7.19" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01728" "29960" "ENSG00000122687" "MRM2" "hsa:29960; Q24JR8; Q9UI43" "" "rRNA modification in the mitochondrion" "1" "0" "0.937" "1.011" "0.862" "0.805" "0.959" "0.853" "0.835" "0.916" "1.167" "394.4" "369.7" "399.0" "340.1" "317.7" "378.4" "336.6" "329.2" "361.2" "460.3" "" "" "" "" "" "" "" "" "" "" "354.6" "299.2" "360.9" "332.0" "262.2" "378.4" "252.0" "290.8" "323.2" "164.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2753373290981074159" "False" "High" "IsMasterProtein" "Q8IXI1" "Mitochondrial Rho GTPase 2 OS=Homo sapiens OX=9606 GN=RHOT2 PE=1 SV=2" "0.000" "False" "5.596" "1" "1" "3" "1" "618" "68.1" "5.86" "6.90" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00071, Pf08355, Pf08356" "89941" "ENSG00000140983" "RHOT2" "A2IDC2; hsa:89941; Q8IXI1; Q8NF53; Q96C13; Q96S17; Q9BT60; Q9H7M8" "" "RHOT2 GTPase cycle" "1" "0" "0.948" "1.015" "0.947" "1.072" "0.851" "0.896" "0.834" "1.035" "0.784" "401.6" "380.7" "407.5" "380.4" "430.3" "341.8" "359.7" "335.1" "415.6" "315.0" "" "" "" "" "" "" "" "" "" "" "361.1" "308.0" "368.6" "371.4" "355.1" "341.8" "269.3" "296.0" "371.8" "112.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9103143806185528671" "False" "High" "IsMasterProtein" "Q86UA1" "Pre-mRNA-processing factor 39 OS=Homo sapiens OX=9606 GN=PRPF39 PE=1 SV=3" "0.000" "False" "5.579" "3" "2" "2" "2" "669" "78.4" "5.40" "5.59" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "" "55015" "ENSG00000185246" "PRPF39" "hsa:55015; Q08AL1; Q08AL2; Q86UA1; Q9NUU5" "" "" "0" "0" "0.965" "1.027" "0.975" "0.678" "1.094" "1.140" "0.986" "1.156" "6.267" "18.8" "18.1" "19.3" "18.3" "12.7" "20.6" "21.4" "18.5" "21.7" "117.8" "" "" "" "" "" "" "" "" "" "" "16.9" "14.7" "17.5" "17.9" "10.5" "20.6" "16.0" "16.4" "19.4" "42.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4156627100779081460" "False" "High" "IsMasterProtein" "Q02446" "Transcription factor Sp4 OS=Homo sapiens OX=9606 GN=SP4 PE=1 SV=2" "0.000" "False" "5.568" "3" "2" "3" "2" "784" "81.9" "7.05" "12.02" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6671" "ENSG00000105866" "SP4" "hsa:6671; O60402; Q02446; Q32M52" "" "" "0" "0" "0.966" "0.951" "1.081" "1.057" "1.043" "1.115" "1.164" "0.994" "1.070" "224.9" "217.2" "213.9" "243.0" "237.8" "234.6" "250.8" "261.7" "223.5" "240.5" "" "" "" "" "" "" "" "" "" "" "202.2" "175.7" "193.4" "237.2" "196.2" "234.6" "187.8" "231.1" "200.0" "85.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4183946520787002263" "False" "High" "IsMasterProtein" "Q9H4B0" "tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=OSGEPL1 PE=1 SV=2" "0.000" "False" "5.548" "5" "2" "2" "2" "414" "45.1" "8.56" "7.54" "2" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00814" "64172" "ENSG00000128694" "OSGEPL1" "hsa:64172; Q96EV9; Q96NH5; Q9H4B0" "" "" "0" "0" "1.072" "1.020" "0.872" "0.980" "0.880" "1.018" "1.038" "0.817" "0.944" "171.5" "183.8" "175.0" "149.6" "168.1" "150.9" "174.6" "178.0" "140.1" "162.0" "" "" "" "" "" "" "" "" "" "" "154.2" "148.8" "158.3" "146.0" "138.7" "150.9" "130.7" "157.2" "125.3" "57.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3653406019681218238" "False" "High" "IsMasterProtein" "Q07002" "Cyclin-dependent kinase 18 OS=Homo sapiens OX=9606 GN=CDK18 PE=1 SV=4" "0.000" "False" "5.544" "4" "2" "5" "1" "474" "54.4" "8.66" "12.33" "2" "other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5129" "ENSG00000117266" "CDK18" "hsa:5129; Q07002; Q5VXQ2; Q6V3A2; Q6V3A3; Q96F90" "" "" "0" "0" "0.715" "0.798" "0.571" "0.625" "0.636" "0.565" "0.639" "0.645" "0.499" "196.0" "140.1" "156.4" "111.8" "122.6" "124.7" "110.8" "125.3" "126.4" "97.8" "" "" "" "" "" "" "" "" "" "" "176.2" "113.4" "141.5" "109.2" "101.2" "124.7" "83.0" "110.6" "113.1" "34.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3917086936507081280" "False" "High" "IsMasterProtein" "Q56P03" "E2F-associated phosphoprotein OS=Homo sapiens OX=9606 GN=EAPP PE=1 SV=4" "0.000" "False" "5.537" "9" "2" "2" "2" "285" "32.7" "5.12" "4.82" "2" "other biological processes" "nucleus;other cell component" "" "Pf10238" "55837" "ENSG00000129518" "EAPP" "hsa:55837; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86" "" "" "0" "0" "0.947" "0.662" "0.826" "0.848" "0.807" "0.853" "0.775" "0.860" "0.737" "109.5" "103.7" "72.4" "90.4" "92.8" "88.3" "93.4" "84.9" "94.2" "80.7" "" "" "" "" "" "" "" "" "" "" "98.4" "83.9" "65.5" "88.3" "76.6" "88.3" "69.9" "75.0" "84.3" "28.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7842510788255330312" "False" "High" "IsMasterProtein" "O75896" "Tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=TUSC2 PE=1 SV=3" "0.000" "False" "5.536" "16" "2" "2" "2" "110" "12.1" "9.69" "6.18" "2" "cell cycle OR cell proliferation;stress response;transport;other biological processes" "mitochondrion" "" "Pf15000" "11334" "ENSG00000114383" "TUSC2" "B2R4Y9; hsa:11334; O75896" "" "" "0" "0" "1.046" "0.965" "1.049" "0.973" "1.090" "1.001" "1.034" "1.010" "0.747" "435.0" "455.1" "419.7" "456.3" "423.4" "474.3" "435.5" "449.7" "439.3" "325.0" "" "" "" "" "" "" "" "" "" "" "391.1" "368.2" "379.6" "445.4" "349.4" "474.3" "326.1" "397.2" "393.1" "116.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5958552957432297313" "False" "High" "IsMasterProtein" "Q9BRJ6" "Uncharacterized protein C7orf50 OS=Homo sapiens OX=9606 GN=C7orf50 PE=1 SV=1" "0.000" "False" "5.503" "17" "2" "2" "2" "194" "22.1" "9.64" "3.19" "2" "" "" "" "Pf10180" "84310" "ENSG00000146540" "C7orf50" "Q9BRJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7560300285237323007" "False" "High" "IsMasterProtein" "Q12980" "GATOR1 complex protein NPRL3 OS=Homo sapiens OX=9606 GN=NPRL3 PE=1 SV=1" "0.000" "False" "5.478" "5" "2" "2" "2" "569" "63.6" "6.98" "6.55" "2" "stress response;developmental processes;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "enzyme regulator activity" "Pf03666" "8131" "ENSG00000103148" "NPRL3" "D3DU40; hsa:8131; Q12980; Q1W6H0; Q4TT56; Q92469" "22q11.2 copy number variation syndrome" "Amino acids regulate mTORC1" "2" "0" "0.945" "0.850" "0.716" "1.140" "0.994" "0.808" "0.790" "0.817" "1.511" "52.0" "49.2" "44.2" "37.2" "59.3" "51.7" "42.0" "41.1" "42.5" "78.6" "" "" "" "" "" "" "" "" "" "" "46.8" "39.8" "40.0" "36.3" "48.9" "51.7" "31.5" "36.3" "38.0" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1955542657671406465" "False" "High" "IsMasterProtein" "O95498" "Pantetheine hydrolase VNN2 OS=Homo sapiens OX=9606 GN=VNN2 PE=1 SV=3" "0.000" "False" "5.462" "4" "2" "2" "2" "520" "58.5" "6.52" "5.27" "2" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00795, Pf19018" "8875" "ENSG00000112303" "VNN2" "A0AUZ3; A6NDY1; A8K4E3; A8K7W0; B2DFZ0; B2DFZ1; B2DFZ2; B2DFZ3; F6XL73; hsa:8875; O95498; Q2XUN1; Q9UJF3; Q9UMW2" "" "Post-translational modification: synthesis of GPI-anchored proteins; Vitamin B5 (pantothenate) metabolism" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2903433267102321467" "False" "High" "IsMasterProtein" "Q9UL03" "Integrator complex subunit 6 OS=Homo sapiens OX=9606 GN=INTS6 PE=1 SV=1" "0.000" "False" "5.457" "2" "2" "2" "2" "887" "100.3" "8.62" "6.39" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf13519, Pf15300" "26512" "ENSG00000102786" "INTS6" "hsa:26512; Q0P664; Q6PJP4; Q9UFK0; Q9UL03; Q9Y5M9" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.022" "1.077" "1.012" "1.124" "0.942" "0.972" "1.083" "0.998" "1.581" "82.8" "84.7" "89.3" "83.8" "93.1" "78.0" "80.6" "89.7" "82.7" "131.0" "" "" "" "" "" "" "" "" "" "" "74.5" "68.5" "80.7" "81.8" "76.8" "78.0" "60.3" "79.2" "74.0" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2095194651549531862" "False" "High" "IsMasterProtein" "O95487" "Protein transport protein Sec24B OS=Homo sapiens OX=9606 GN=SEC24B PE=1 SV=2" "0.000" "False" "5.453" "1" "2" "2" "1" "1268" "137.3" "6.67" "7.86" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "Pf00626, Pf04810, Pf04811, Pf04815, Pf08033" "10427" "ENSG00000138802" "SEC24B" "B7ZKM8; B7ZKN4; hsa:10427; O95487; Q0VG08" "Sterol regulatory element-binding proteins (SREBP) signaling" "MHC class II antigen presentation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; COPII-mediated vesicle transport; Cargo concentration in the ER; Regulation of cholesterol biosynthesis by SREBP (SREBF); Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5073984553663010392" "False" "High" "IsMasterProtein" "Q86UV5" "Ubiquitin carboxyl-terminal hydrolase 48 OS=Homo sapiens OX=9606 GN=USP48 PE=1 SV=1" "0.000" "False" "5.447" "2" "2" "2" "2" "1035" "119.0" "6.05" "6.07" "2" "protein metabolism" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00443, Pf06337" "84196" "ENSG00000090686" "USP48" "B7ZKS7; hsa:84196; Q2M3I4; Q5SZI4; Q5T3T5; Q6NX53; Q86UV5; Q8N3F6; Q96F64; Q96IQ3; Q9H5N3; Q9H5T7; Q9NUJ6; Q9NXR0" "" "Ub-specific processing proteases" "1" "0" "1.016" "1.048" "0.905" "1.109" "1.005" "1.159" "0.920" "1.154" "2.635" "90.7" "92.1" "95.0" "82.1" "100.6" "91.2" "105.1" "83.4" "104.6" "239.0" "" "" "" "" "" "" "" "" "" "" "81.6" "74.6" "85.9" "80.1" "83.0" "91.2" "78.7" "73.7" "93.6" "85.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1664770674535561933" "False" "High" "IsMasterProtein" "Q96T37" "RNA-binding protein 15 OS=Homo sapiens OX=9606 GN=RBM15 PE=1 SV=2" "0.000" "False" "5.444" "3" "2" "2" "2" "977" "107.1" "10.08" "7.47" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity" "Pf00076, Pf07744" "64783" "ENSG00000162775" "RBM15" "A1A693; hsa:64783; Q3ZB86; Q4V760; Q5D058; Q5T613; Q86VW9; Q96PE4; Q96SC5; Q96SC6; Q96SC9; Q96SD0; Q96T37; Q96T38; Q9BRA5; Q9H6R8; Q9H9Y0" "" "" "0" "0" "1.200" "0.959" "1.100" "1.303" "1.279" "1.161" "1.183" "1.198" "2.099" "64.1" "77.0" "61.5" "70.6" "83.5" "82.0" "74.5" "75.9" "76.8" "134.6" "" "" "" "" "" "" "" "" "" "" "57.7" "62.3" "55.7" "68.9" "68.9" "82.0" "55.8" "67.0" "68.8" "48.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1585817169106109779" "False" "High" "IsMasterProtein" "Q9P2D1" "Chromodomain-helicase-DNA-binding protein 7 OS=Homo sapiens OX=9606 GN=CHD7 PE=1 SV=3" "0.000" "False" "5.443" "0" "1" "2" "1" "2997" "335.7" "6.34" "3.99" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "55636" "ENSG00000171316" "CHD7" "D0VBA5; E9PNZ2; hsa:55636; Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; Q9P2D1" "Kallmann syndrome" "" "1" "0" "0.739" "0.963" "0.888" "1.036" "1.028" "1.060" "0.857" "1.093" "0.888" "67.7" "50.0" "65.2" "60.1" "70.1" "69.6" "71.7" "58.0" "74.0" "60.1" "" "" "" "" "" "" "" "" "" "" "60.8" "40.4" "59.0" "58.6" "57.8" "69.6" "53.7" "51.2" "66.2" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3841644939449259778" "False" "High" "IsMasterProtein" "Q4LDG9" "Dynein axonemal light chain 1 OS=Homo sapiens OX=9606 GN=DNAL1 PE=1 SV=1" "0.000" "False" "5.442" "12" "2" "2" "2" "190" "21.5" "6.10" "5.26" "2" "cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf12799" "83544" "ENSG00000119661" "DNAL1" "B2RD38; hsa:83544; Q4LDG9; Q5JPB7; Q9BS43" "Ciliopathies" "" "1" "0" "0.991" "1.002" "0.981" "1.075" "1.004" "0.940" "1.041" "1.045" "0.950" "158.5" "157.1" "158.8" "155.5" "170.4" "159.1" "149.0" "165.0" "165.7" "150.7" "" "" "" "" "" "" "" "" "" "" "142.5" "127.1" "143.6" "151.8" "140.6" "159.1" "111.6" "145.8" "148.3" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1345191434985933779" "False" "High" "IsMasterProtein" "Q9UF56" "F-box/LRR-repeat protein 17 OS=Homo sapiens OX=9606 GN=FBXL17 PE=1 SV=3" "0.000" "False" "5.426" "5" "2" "2" "2" "701" "75.6" "8.07" "5.19" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf12937, Pf13516" "64839" "ENSG00000145743" "FBXL17" "A1A4E3; hsa:64839; Q9UF56" "Hedgehog signaling pathway" "Regulation of BACH1 activity" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1951608314028341164" "False" "High" "IsMasterProtein" "Q4U2R6" "Large ribosomal subunit protein mL51 OS=Homo sapiens OX=9606 GN=MRPL51 PE=1 SV=1" "0.000" "False" "5.425" "19" "2" "2" "2" "128" "15.1" "11.27" "6.07" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10244" "51258" "ENSG00000111639" "MRPL51" "hsa:51258; Q4U2R6; Q96Q57; Q9BQ36; Q9P0N7" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4567106574901643860" "False" "High" "IsMasterProtein" "O60826" "Coiled-coil domain-containing protein 22 OS=Homo sapiens OX=9606 GN=CCDC22 PE=1 SV=1" "0.000" "False" "5.424" "6" "2" "2" "2" "627" "70.7" "6.74" "4.74" "2" "transport;other biological processes" "cytosol;cytoskeleton;nucleus;other cytoplasmic organelle" "other molecular function" "Pf05667, Pf21674" "28952" "ENSG00000101997" "CCDC22" "A8K7G1; hsa:28952; O60826" "" "Neddylation" "1" "0" "1.207" "1.285" "1.156" "1.165" "1.153" "1.216" "1.190" "1.106" "2.410" "58.7" "70.9" "75.5" "67.9" "68.5" "67.7" "71.4" "69.9" "64.9" "141.5" "" "" "" "" "" "" "" "" "" "" "52.8" "57.4" "68.3" "66.3" "56.5" "67.7" "53.5" "61.7" "58.1" "50.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6342285970436861386" "False" "High" "IsMasterProtein" "Q9UPM8" "AP-4 complex subunit epsilon-1 OS=Homo sapiens OX=9606 GN=AP4E1 PE=1 SV=2" "0.000" "False" "5.420" "3" "2" "2" "2" "1137" "127.2" "5.99" "3.20" "2" "transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf01602, Pf14807" "23431" "ENSG00000081014" "AP4E1" "A0AVD6; A1L4A9; A6NNX7; H0YKX4; hsa:23431; Q68D31; Q9UPM8; Q9Y588" "" "Golgi Associated Vesicle Biogenesis; Lysosome Vesicle Biogenesis" "2" "0" "0.861" "1.013" "0.691" "1.278" "1.081" "1.651" "1.186" "1.281" "0.653" "12.1" "10.4" "12.2" "8.3" "15.4" "13.0" "19.9" "14.3" "15.4" "7.9" "" "" "" "" "" "" "" "" "" "" "10.8" "8.4" "11.0" "8.1" "12.7" "13.0" "14.9" "12.6" "13.8" "2.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354971542348250461" "False" "High" "IsMasterProtein" "Q96BW9" "Phosphatidate cytidylyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=TAMM41 PE=1 SV=2" "0.000" "False" "5.412" "6" "2" "2" "2" "452" "51.0" "7.94" "5.51" "2" "other metabolic processes" "other membranes;mitochondrion" "other molecular function" "Pf09139" "132001" "ENSG00000144559" "TAMM41" "B4DIY7; C9J2U4; hsa:132001; Q96BW9" "" "" "0" "0" "1.206" "1.371" "1.738" "1.074" "0.734" "1.355" "1.579" "1.507" "1.039" "22.6" "27.2" "30.9" "39.2" "24.2" "16.6" "30.6" "35.6" "34.0" "23.5" "" "" "" "" "" "" "" "" "" "" "20.3" "22.0" "28.0" "38.3" "20.0" "16.6" "22.9" "31.5" "30.4" "8.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "743722838785437812" "False" "High" "IsMasterProtein" "Q12846" "Syntaxin-4 OS=Homo sapiens OX=9606 GN=STX4 PE=1 SV=2" "0.000" "False" "5.408" "7" "2" "2" "2" "297" "34.2" "6.28" "6.85" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00804, Pf05739" "6810" "ENSG00000103496" "STX4" "A8MXY0; hsa:6810; Q12846; Q15525; Q6FHE8" "Insulin signaling; Vasopressin-regulated water reabsorption" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; ER-Phagosome pathway; trans-Golgi Network Vesicle Budding; Disinhibition of SNARE formation; Other interleukin signaling" "7" "0" "1.100" "1.161" "0.912" "1.183" "1.021" "1.237" "0.957" "1.161" "1.000" "57.7" "63.4" "66.9" "52.6" "68.2" "58.9" "71.4" "55.2" "67.0" "57.7" "" "" "" "" "" "" "" "" "" "" "51.9" "51.3" "60.6" "51.3" "56.3" "58.9" "53.4" "48.7" "59.9" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1812058185286656363" "False" "High" "IsMasterProtein" "Q9NWZ8" "Gem-associated protein 8 OS=Homo sapiens OX=9606 GN=GEMIN8 PE=1 SV=1" "0.000" "False" "5.408" "8" "2" "2" "2" "242" "28.6" "6.80" "5.50" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "" "Pf15348" "54960" "ENSG00000046647" "GEMIN8" "C4AMC4; hsa:54960; Q2LJ66; Q6ZV27; Q9NWZ8" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.048" "0.982" "1.054" "1.203" "1.080" "1.013" "1.183" "1.063" "1.916" "62.9" "65.9" "61.7" "66.2" "75.6" "67.9" "63.7" "74.4" "66.8" "120.5" "" "" "" "" "" "" "" "" "" "" "56.5" "53.3" "55.8" "64.7" "62.4" "67.9" "47.7" "65.7" "59.8" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1448578471139674410" "False" "High" "IsMasterProtein" "Q6PJ69" "E3 ubiquitin-protein ligase TRIM65 OS=Homo sapiens OX=9606 GN=TRIM65 PE=1 SV=3" "0.000" "False" "5.388" "4" "2" "2" "2" "517" "57.3" "6.70" "5.52" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00097, Pf00622, Pf00643" "201292" "ENSG00000141569" "TRIM65" "hsa:201292; Q4G0F0; Q6DKJ6; Q6PJ69; Q9BRP6" "" "" "0" "0" "1.056" "1.164" "0.912" "1.113" "1.136" "1.092" "1.032" "0.958" "2.385" "226.6" "239.2" "263.7" "206.7" "252.1" "257.4" "247.4" "233.8" "217.0" "540.4" "" "" "" "" "" "" "" "" "" "" "203.7" "193.6" "238.5" "201.8" "208.0" "257.4" "185.2" "206.5" "194.1" "192.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2805936399056232458" "False" "High" "IsMasterProtein" "P78352" "Disks large homolog 4 OS=Homo sapiens OX=9606 GN=DLG4 PE=1 SV=3" "0.000" "False" "5.367" "4" "3" "3" "1" "724" "80.4" "5.88" "9.17" "3" "cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00018, Pf00595, Pf00625, Pf10600, Pf10608" "1742" "ENSG00000132535" "DLG4" "B7Z1S1; G5E939; hsa:1742; P78352; Q92941; Q9UKK8" "BDNF-TrkB signaling; NO/cGMP/PKG mediated neuroprotection; Synaptic signaling pathways associated with autism spectrum disorder; Fragile X syndrome; NRXN1 deletion syndrome; Cell lineage map for neuronal differentiation; HDAC6 interactions in the central nervous system" "RAF/MAP kinase cascade; Assembly and cell surface presentation of NMDA receptors; Neurexins and neuroligins; Signaling by ERBB4; RHO GTPases activate CIT; Ras activation upon Ca2+ influx through NMDA receptor; Unblocking of NMDA receptors, glutamate binding and activation; Synaptic adhesion-like molecules; Negative regulation of NMDA receptor-mediated neuronal transmission; Long-term potentiation; Trafficking of AMPA receptors; LGI-ADAM interactions; NrCAM interactions; Activation of Ca-permeable Kainate Receptor" "21" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8503334225233124721" "False" "High" "IsMasterProtein" "P78317" "E3 ubiquitin-protein ligase RNF4 OS=Homo sapiens OX=9606 GN=RNF4 PE=1 SV=1" "0.000" "False" "5.353" "6" "2" "2" "2" "190" "21.3" "7.03" "8.68" "2" "protein metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13639" "6047" "ENSG00000063978" "RNF4" "B2R6D6; D6RF58; P78317; Q49AR8" "Androgen receptor signaling pathway" "Processing of DNA double-strand break ends; Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.983" "1.200" "1.046" "0.999" "1.121" "0.933" "1.085" "1.124" "1.152" "111.8" "109.9" "134.1" "116.9" "111.6" "125.3" "104.3" "121.3" "125.7" "128.8" "" "" "" "" "" "" "" "" "" "" "100.5" "88.9" "121.3" "114.1" "92.1" "125.3" "78.1" "107.2" "112.5" "46.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-646999670011784093" "False" "High" "IsMasterProtein" "Q96S55" "ATPase WRNIP1 OS=Homo sapiens OX=9606 GN=WRNIP1 PE=1 SV=2" "0.000" "False" "5.351" "4" "2" "4" "2" "665" "72.1" "6.10" "8.88" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00004, Pf12002, Pf16193, Pf18279" "56897" "ENSG00000124535" "WRNIP1" "B2RDB0; hsa:56897; Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q96S55; Q9H681; Q9NRJ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-331948696601358906" "False" "High" "IsMasterProtein" "Q969T7" "7-methylguanosine phosphate-specific 5'-nucleotidase OS=Homo sapiens OX=9606 GN=NT5C3B PE=1 SV=4" "0.000" "False" "5.349" "6" "2" "2" "2" "300" "34.4" "6.38" "3.52" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf05822" "115024" "ENSG00000141698" "NT5C3B" "A8MWB9; C9JKC4; hsa:115024; Q7L3B7; Q969T7" "" "mRNA decay by 3' to 5' exoribonuclease" "1" "0" "1.101" "1.149" "0.796" "0.826" "0.987" "0.797" "0.872" "0.853" "0.748" "204.4" "225.1" "234.7" "162.8" "168.9" "201.8" "162.9" "178.1" "174.4" "152.8" "" "" "" "" "" "" "" "" "" "" "183.7" "182.1" "212.3" "158.9" "139.4" "201.8" "122.0" "157.3" "156.0" "54.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8841941710175491915" "False" "High" "IsMasterProtein" "Q5HYK3" "2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Homo sapiens OX=9606 GN=COQ5 PE=1 SV=2" "0.000" "False" "5.338" "7" "2" "2" "2" "327" "37.1" "6.95" "3.73" "2" "other metabolic processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf01209" "84274" "ENSG00000110871" "COQ5" "B2RDU9; B3GK62; B4DEJ4; hsa:84274; Q32Q28; Q53HH0; Q5HYK3; Q96LV1; Q9BSP8" "" "Ubiquinol biosynthesis" "1" "0" "0.884" "0.930" "1.210" "0.796" "1.093" "0.970" "0.956" "0.909" "1.022" "116.5" "102.9" "108.3" "141.0" "92.7" "127.3" "113.0" "111.3" "105.9" "119.1" "" "" "" "" "" "" "" "" "" "" "104.7" "83.3" "97.9" "137.6" "76.5" "127.3" "84.6" "98.3" "94.7" "42.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-737330374784277396" "False" "High" "IsMasterProtein" "Q6ZV73" "FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens OX=9606 GN=FGD6 PE=1 SV=2" "0.000" "False" "5.331" "1" "2" "2" "2" "1430" "160.7" "7.03" "6.65" "2" "cell organization and biogenesis;other biological processes" "cytoskeleton;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621, Pf01363" "55785" "ENSG00000180263" "FGD6" "hsa:55785; Q6ZR53; Q6ZV73; Q7Z2Z7; Q96D44; Q9NUR8; Q9P2I5" "" "" "0" "0" "1.095" "1.007" "1.038" "1.206" "1.089" "1.156" "0.995" "1.014" "2.112" "303.6" "332.4" "305.8" "315.2" "366.1" "330.7" "351.0" "302.2" "308.0" "641.1" "" "" "" "" "" "" "" "" "" "" "273.0" "269.0" "276.6" "307.7" "302.1" "330.7" "262.8" "266.9" "275.6" "228.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-233875038678641110" "False" "High" "IsMasterProtein" "Q7Z5U6" "WD repeat-containing protein 53 OS=Homo sapiens OX=9606 GN=WDR53 PE=1 SV=1" "0.000" "False" "5.329" "5" "1" "1" "1" "358" "39.0" "6.52" "5.13" "1" "" "" "" "Pf00400, Pf12894" "348793" "ENSG00000185798" "WDR53" "A0MNP1; hsa:348793; Q7Z5U6" "3q29 copy number variation syndrome" "" "1" "0" "1.024" "0.957" "0.982" "1.057" "1.084" "1.001" "0.980" "1.167" "0.951" "107.3" "109.9" "102.7" "105.3" "113.4" "116.3" "107.3" "105.1" "125.2" "102.0" "" "" "" "" "" "" "" "" "" "" "96.4" "88.9" "92.9" "102.8" "93.6" "116.3" "80.4" "92.8" "112.0" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2029862218257081345" "False" "High" "IsMasterProtein" "O15318" "DNA-directed RNA polymerase III subunit RPC7 OS=Homo sapiens OX=9606 GN=POLR3G PE=1 SV=2" "0.000" "False" "5.322" "12" "2" "2" "2" "223" "25.9" "4.63" "4.14" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf11705" "10622" "ENSG00000113356" "POLR3G" "A8MTH0; hsa:10622; O15318" "Pyrimidine metabolism; Cytosolic DNA-sensing pathway; TAR syndrome" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "10" "0" "0.870" "1.119" "1.029" "1.072" "1.048" "1.022" "1.059" "1.192" "1.224" "148.8" "129.5" "166.6" "153.1" "159.4" "155.9" "152.1" "157.6" "177.3" "182.2" "" "" "" "" "" "" "" "" "" "" "133.8" "104.8" "150.7" "149.5" "131.6" "155.9" "113.9" "139.2" "158.6" "65.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7080183333196327832" "False" "High" "IsMasterProtein" "Q86X95" "Corepressor interacting with RBPJ 1 OS=Homo sapiens OX=9606 GN=CIR1 PE=1 SV=1" "0.000" "False" "5.321" "3" "2" "2" "2" "450" "52.3" "9.86" "3.55" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10197" "9541" "ENSG00000138433" "CIR1" "A6NFI6; A8K8M4; hsa:9541; O95367; Q12804; Q4G1B9; Q6PJI4; Q86X95; Q8IWI2" "Notch signaling pathway" "" "1" "0" "1.114" "0.850" "0.895" "1.239" "0.981" "0.938" "1.199" "0.963" "0.650" "44.6" "49.6" "37.9" "39.9" "55.2" "43.7" "41.8" "53.4" "42.9" "29.0" "" "" "" "" "" "" "" "" "" "" "40.1" "40.2" "34.2" "38.9" "45.6" "43.7" "31.3" "47.2" "38.4" "10.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-21239567639981216" "False" "High" "IsMasterProtein" "Q9BRA0" "N-alpha-acetyltransferase 38, NatC auxiliary subunit OS=Homo sapiens OX=9606 GN=NAA38 PE=1 SV=1" "0.000" "False" "5.315" "14" "2" "3" "2" "125" "13.5" "5.53" "7.52" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf01423" "84316" "ENSG00000183011" "NAA38" "hsa:84316; Q8N4M0; Q9BRA0" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3275196182656961977" "False" "High" "IsMasterProtein" "Q8WXB1" "Protein N-lysine methyltransferase METTL21A OS=Homo sapiens OX=9606 GN=METTL21A PE=1 SV=2" "0.000" "False" "5.308" "7" "2" "4" "2" "218" "24.6" "6.27" "13.11" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "151194" "ENSG00000144401" "METTL21A" "hsa:151194; Q53RV0; Q8N1Z9; Q8WXB1; Q96GH6" "" "Protein methylation" "1" "0" "1.083" "0.962" "1.048" "1.107" "0.926" "0.992" "0.987" "1.026" "0.778" "343.6" "372.2" "330.7" "360.1" "380.4" "318.2" "340.9" "338.9" "352.7" "267.3" "" "" "" "" "" "" "" "" "" "" "308.9" "301.2" "299.1" "351.5" "313.9" "318.2" "255.3" "299.4" "315.6" "95.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-985181273239411309" "False" "High" "IsMasterProtein" "Q5JUR7" "Testis-expressed protein 30 OS=Homo sapiens OX=9606 GN=TEX30 PE=1 SV=1" "0.000" "False" "5.289" "11" "3" "3" "3" "227" "25.6" "8.66" "8.29" "3" "" "" "" "Pf20408" "93081" "ENSG00000151287" "TEX30" "hsa:93081; Q5JUR7; Q5JUR8; Q96KZ8" "" "" "0" "0" "1.106" "1.056" "0.962" "0.996" "0.985" "1.209" "1.018" "1.022" "1.786" "105.8" "117.0" "111.7" "101.8" "105.3" "104.2" "127.9" "107.7" "108.1" "188.9" "" "" "" "" "" "" "" "" "" "" "95.1" "94.7" "101.0" "99.4" "86.9" "104.2" "95.8" "95.1" "96.7" "67.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2668424523932492370" "False" "High" "IsMasterProtein" "Q9BVQ7" "ATPase family gene 2 protein homolog B OS=Homo sapiens OX=9606 GN=AFG2B PE=1 SV=2" "0.000" "False" "5.287" "4" "2" "2" "2" "753" "80.7" "8.09" "3.00" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00004, Pf17862" "79029" "ENSG00000171763" "AFG2B" "C9JHR5; hsa:79029; Q9BVQ7; Q9H8W7; Q9HA41" "" "" "0" "0" "1.000" "1.023" "0.934" "0.961" "0.981" "1.075" "0.932" "0.992" "0.887" "149.5" "149.6" "152.9" "139.6" "143.7" "146.6" "160.8" "139.3" "148.3" "132.6" "" "" "" "" "" "" "" "" "" "" "134.4" "121.0" "138.3" "136.3" "118.6" "146.6" "120.4" "123.0" "132.7" "47.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5331704730055142476" "False" "High" "IsMasterProtein" "Q8IVB5" "LIX1-like protein OS=Homo sapiens OX=9606 GN=LIX1L PE=1 SV=1" "0.000" "False" "5.279" "5" "2" "2" "2" "337" "36.5" "8.56" "6.44" "2" "cell organization and biogenesis;other metabolic processes" "other cell component" "" "Pf14954" "128077" "ENSG00000271601" "LIX1L" "hsa:128077; Q6AI36; Q8IVB5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3010506436641867552" "False" "High" "IsMasterProtein" "Q8WWW0" "Ras association domain-containing protein 5 OS=Homo sapiens OX=9606 GN=RASSF5 PE=1 SV=1" "0.000" "False" "5.275" "4" "2" "2" "2" "418" "47.1" "9.14" "7.07" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00130, Pf00788, Pf16517" "83593" "ENSG00000266094" "RASSF5" "A8K1E6; hsa:83593; Q5SY32; Q8WWV9; Q8WWW0; Q8WXF4; Q9BT99" "Fibrin complement receptor 3 signaling pathway; Ras signaling; Non-small cell lung cancer; Leukocyte-intrinsic Hippo pathway functions; Pleural mesothelioma" "" "5" "0" "1.075" "1.085" "1.061" "1.067" "1.109" "1.128" "1.023" "1.108" "1.626" "258.0" "277.2" "279.8" "273.8" "275.3" "286.0" "290.9" "264.0" "286.0" "419.4" "" "" "" "" "" "" "" "" "" "" "231.9" "224.3" "253.1" "267.3" "227.2" "286.0" "217.8" "233.2" "255.9" "149.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7198883007019988074" "False" "High" "IsMasterProtein" "Cont_Q8N1N4" "Keratin, type II cytoskeletal 78 OS=Homo sapiens OX=9606 GN=KRT78 PE=1 SV=2" "0.000" "True" "5.273" "4" "3" "3" "1" "520" "56.8" "6.02" "8.64" "3" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "196374" "ENSG00000170423" "KRT78" "A8K4D6; hsa:196374; Q5HYM7; Q7RTT2; Q8N1N4" "" "Formation of the cornified envelope" "2" "0" "0.610" "1.260" "1.194" "0.497" "1.406" "0.941" "1.061" "0.552" "1.969" "34.9" "21.3" "43.9" "41.6" "17.3" "49.0" "32.8" "37.0" "19.3" "68.6" "" "" "" "" "" "" "" "" "" "" "31.3" "17.2" "39.7" "40.6" "14.3" "49.0" "24.6" "32.7" "17.2" "24.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5479231618500312272" "False" "High" "IsMasterProtein" "Q8NF91" "Nesprin-1 OS=Homo sapiens OX=9606 GN=SYNE1 PE=1 SV=4" "0.000" "False" "5.260" "0" "2" "3" "2" "8797" "1010.5" "5.53" "7.31" "2" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23345" "ENSG00000131018" "SYNE1" "B3W695; E7EQI5; H0Y4C0; O94890; Q3ZCV0; Q5JV19; Q5JV22; Q8N9P7; Q8NF91; Q8TCP1; Q8WWW6; Q8WWW7; Q8WXF6; Q96N17; Q9C0A7; Q9H525; Q9H526; Q9NS36; Q9NU50; Q9UJ06; Q9UJ07; Q9ULF8" "Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "2" "0" "0.961" "0.965" "0.796" "0.999" "0.886" "0.900" "0.945" "0.968" "0.792" "157.2" "151.0" "151.7" "125.1" "157.0" "139.2" "141.5" "148.5" "152.1" "124.5" "" "" "" "" "" "" "" "" "" "" "141.3" "122.2" "137.2" "122.1" "129.6" "139.2" "106.0" "131.2" "136.1" "44.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158291117488105620" "False" "High" "IsMasterProtein" "Q19AV6" "Zinc finger SWIM domain-containing protein 7 OS=Homo sapiens OX=9606 GN=ZSWIM7 PE=1 SV=1" "0.000" "False" "5.250" "11" "1" "2" "1" "140" "15.4" "7.15" "4.88" "1" "DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04434" "125150" "ENSG00000214941" "ZSWIM7" "hsa:125150; Q19AV6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2673167889447724756" "False" "High" "IsMasterProtein" "Q8IZD4" "mRNA-decapping enzyme 1B OS=Homo sapiens OX=9606 GN=DCP1B PE=1 SV=2" "0.000" "False" "5.250" "3" "2" "2" "2" "617" "67.7" "8.56" "5.43" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf06058, Pf16741" "196513" "ENSG00000151065; ENSG00000284850" "DCP1B" "B4DRD1; hsa:196513; Q86XH9; Q8IZD4; Q96BP8; Q96MZ8" "" "mRNA decay by 5' to 3' exoribonuclease" "1" "0" "1.054" "1.161" "1.027" "1.081" "1.071" "1.054" "1.002" "1.058" "1.577" "136.0" "143.4" "157.9" "139.7" "147.0" "145.8" "143.4" "136.3" "143.9" "214.5" "" "" "" "" "" "" "" "" "" "" "122.3" "116.1" "142.8" "136.3" "121.3" "145.8" "107.4" "120.4" "128.7" "76.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8116747825737560157" "False" "High" "IsMasterProtein" "O15235" "Small ribosomal subunit protein uS12m OS=Homo sapiens OX=9606 GN=MRPS12 PE=1 SV=1" "0.000" "False" "5.248" "18" "3" "3" "3" "138" "15.2" "10.29" "7.94" "3" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00164" "6183" "ENSG00000128626; ENSG00000283018" "MRPS12" "hsa:6183; O15235; Q53X98" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1625803312962444269" "False" "High" "IsMasterProtein" "Q15269" "Periodic tryptophan protein 2 homolog OS=Homo sapiens OX=9606 GN=PWP2 PE=1 SV=2" "0.000" "False" "5.229" "2" "2" "4" "2" "919" "102.4" "6.15" "12.48" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400, Pf04003" "5822" "ENSG00000241945" "PWP2" "B2RAG8; hsa:5822; Q15269; Q96A77" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.832" "0.922" "0.689" "0.941" "1.255" "0.896" "0.815" "1.022" "0.433" "85.7" "71.3" "79.0" "59.1" "80.7" "107.6" "76.8" "69.9" "87.6" "37.1" "" "" "" "" "" "" "" "" "" "" "77.1" "57.7" "71.5" "57.7" "66.6" "107.6" "57.5" "61.7" "78.4" "13.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2810950685469585295" "False" "High" "IsMasterProtein" "Q2TBE0" "CWF19-like protein 2 OS=Homo sapiens OX=9606 GN=CWF19L2 PE=1 SV=4" "0.000" "False" "5.227" "2" "2" "2" "2" "894" "103.7" "8.65" "5.97" "2" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf04676, Pf04677" "143884" "ENSG00000152404" "CWF19L2" "A4FU66; A4FU67; A4FU68; A8KAD6; hsa:143884; Q2TBE0; Q6PHW1; Q96MI1" "" "mRNA Splicing - Major Pathway" "1" "0" "0.955" "1.068" "1.104" "1.064" "1.130" "0.973" "1.005" "1.071" "1.514" "74.5" "71.1" "79.5" "82.2" "79.2" "84.2" "72.5" "74.9" "79.7" "112.8" "" "" "" "" "" "" "" "" "" "" "66.9" "57.6" "71.9" "80.2" "65.4" "84.2" "54.3" "66.1" "71.3" "40.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1198198230857353565" "False" "High" "IsMasterProtein" "O43169" "Cytochrome b5 type B OS=Homo sapiens OX=9606 GN=CYB5B PE=1 SV=3" "0.000" "False" "5.226" "11" "2" "2" "2" "150" "16.7" "4.97" "6.03" "2" "other metabolic processes;stress response" "other membranes;mitochondrion;other cell component" "enzyme regulator activity;other molecular function" "Pf00173" "80777" "ENSG00000103018" "CYB5B" "A8K6B1; hsa:80777; J3KNF8; O43169; Q96CC3; Q9BT35" "Oxidation by cytochrome P450" "Sphingolipid de novo biosynthesis; Phase I - Functionalization of compounds" "3" "0" "1.019" "1.065" "0.976" "0.910" "0.960" "1.045" "1.142" "0.886" "1.470" "134.4" "137.0" "143.1" "131.2" "122.4" "129.0" "140.5" "153.6" "119.1" "197.6" "" "" "" "" "" "" "" "" "" "" "120.9" "110.8" "129.4" "128.1" "101.0" "129.0" "105.2" "135.6" "106.6" "70.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3524427554300644274" "False" "High" "IsMasterProtein" "Q5FBB7" "Shugoshin 1 OS=Homo sapiens OX=9606 GN=SGO1 PE=1 SV=1" "0.000" "False" "5.197" "3" "2" "2" "2" "561" "64.2" "9.16" "5.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07557, Pf07558" "151648" "ENSG00000129810" "SGO1" "hsa:151648; Q588H5; Q5FBB4; Q5FBB5; Q5FBB6; Q5FBB7; Q5FBB8; Q8N579; Q8WVL0; Q9BVA8; Q9H275" "Cohesin complex - Cornelia de Lange syndrome" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7641291098458873844" "False" "High" "IsMasterProtein" "Q8IVF5" "Rho guanine nucleotide exchange factor TIAM2 OS=Homo sapiens OX=9606 GN=TIAM2 PE=1 SV=4" "0.000" "False" "5.192" "1" "2" "2" "2" "1701" "190.0" "7.21" "7.01" "2" "signal transduction;other biological processes" "other membranes;cytosol;other cell component" "enzyme regulator activity" "Pf00169, Pf00595, Pf00621, Pf18385" "26230" "ENSG00000146426" "TIAM2" "B2RP56; C9JZV2; hsa:26230; Q6NXN9; Q6ZUP9; Q8IVF5; Q9UFG6; Q9UKV9; Q9UKW0" "Chemokine signaling pathway" "PPARA activates gene expression; RAC1 GTPase cycle; NRAGE signals death through JNK; G alpha (12/13) signalling events" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5856391887248193599" "False" "High" "IsMasterProtein" "Q9H4H8" "Protein FAM83D OS=Homo sapiens OX=9606 GN=FAM83D PE=1 SV=3" "0.000" "False" "5.191" "3" "2" "2" "2" "585" "64.4" "6.54" "6.36" "2" "cell cycle OR cell proliferation;signal transduction;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07894" "81610" "ENSG00000101447" "FAM83D" "B4E1I7; hsa:81610; Q5THR2; Q68EN1; Q6P457; Q7Z6H0; Q96DF5; Q96N89; Q9BVM8; Q9H4H8" "" "Signaling by EGFR" "1" "0" "0.947" "1.083" "0.983" "1.073" "1.034" "1.072" "0.993" "0.950" "1.495" "151.3" "143.3" "163.8" "148.8" "162.4" "156.5" "162.2" "150.3" "143.8" "226.3" "" "" "" "" "" "" "" "" "" "" "136.1" "115.9" "148.2" "145.3" "134.0" "156.5" "121.4" "132.7" "128.7" "80.8" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8369123714013872102" "False" "High" "IsMasterProtein" "Q07065" "Cytoskeleton-associated protein 4 OS=Homo sapiens OX=9606 GN=CKAP4 PE=1 SV=2" "0.000" "False" "5.187" "3" "2" "2" "1" "602" "66.0" "5.92" "5.50" "2" "" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "" "" "10970" "ENSG00000136026" "CKAP4" "hsa:10970; Q07065; Q504S5; Q53ES6" "" "Neutrophil degranulation; RND2 GTPase cycle; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; RND3 GTPase cycle; Surfactant metabolism" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3660069339337031106" "False" "High" "IsMasterProtein" "Q5T1R4" "Transcription factor HIVEP3 OS=Homo sapiens OX=9606 GN=HIVEP3 PE=1 SV=1" "0.000" "False" "5.161" "1" "2" "2" "2" "2406" "259.3" "7.81" "5.27" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "59269" "ENSG00000127124" "HIVEP3" "A7YY91; hsa:59269; Q5T1R4; Q5T1R5; Q9BZS0; Q9HCL7" "" "Regulation of RUNX2 expression and activity" "1" "0" "1.059" "0.971" "1.048" "0.954" "1.180" "1.244" "1.056" "1.346" "1.184" "29.1" "30.8" "28.2" "30.5" "27.7" "34.3" "36.2" "30.7" "39.1" "34.4" "" "" "" "" "" "" "" "" "" "" "26.2" "24.9" "25.5" "29.8" "22.9" "34.3" "27.1" "27.1" "35.0" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9146373126346510516" "False" "High" "IsMasterProtein" "Q96SL8" "Flt3-interacting zinc finger protein 1 OS=Homo sapiens OX=9606 GN=FIZ1 PE=1 SV=2" "0.000" "False" "5.159" "7" "3" "3" "3" "496" "52.0" "8.19" "8.34" "3" "other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00096" "84922" "ENSG00000179943" "FIZ1" "A2RU72; Q6ZMJ7; Q96SL8" "" "" "0" "0" "0.958" "1.060" "1.052" "1.036" "0.967" "1.038" "0.914" "0.892" "1.015" "115.7" "110.8" "122.6" "121.7" "119.8" "111.9" "120.1" "105.7" "103.1" "117.4" "" "" "" "" "" "" "" "" "" "" "104.0" "89.7" "110.9" "118.8" "98.9" "111.9" "89.9" "93.3" "92.3" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5896962611559729209" "False" "High" "IsMasterProtein" "O14734" "Acyl-coenzyme A thioesterase 8 OS=Homo sapiens OX=9606 GN=ACOT8 PE=1 SV=1" "0.000" "False" "5.153" "5" "2" "2" "2" "319" "35.9" "7.56" "5.60" "2" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf02551, Pf13622" "10005" "ENSG00000101473" "ACOT8" "hsa:10005; O14734; O15261; Q17RX4" "" "Peroxisomal protein import; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; alpha-linolenic acid (ALA) metabolism; Beta-oxidation of pristanoyl-CoA; Beta-oxidation of very long chain fatty acids" "5" "0" "1.232" "1.415" "1.321" "1.171" "1.236" "1.216" "1.124" "1.322" "1.449" "71.5" "88.1" "101.2" "94.5" "83.7" "88.4" "86.9" "80.4" "94.5" "103.6" "" "" "" "" "" "" "" "" "" "" "64.3" "71.3" "91.5" "92.2" "69.1" "88.4" "65.1" "71.0" "84.6" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-203379576220599078" "False" "High" "IsMasterProtein" "Q13158" "FAS-associated death domain protein OS=Homo sapiens OX=9606 GN=FADD PE=1 SV=1" "0.000" "False" "5.144" "10" "2" "2" "2" "208" "23.3" "5.69" "7.04" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00531, Pf01335" "8772" "ENSG00000168040" "FADD" "hsa:8772; Q13158; Q14866; Q6IBR4" "TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; Nanomaterial induced apoptosis; Nanoparticle triggered regulated necrosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; Apoptosis modulation by HSP70; Novel intracellular components of RIG-I-like receptor pathway; VEGFA-VEGFR2 signaling; Measles virus infection; Cytosolic DNA-sensing pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - apoptosis; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Alzheimer's disease; Toll-like receptor signaling pathway" "Regulation of TNFR1 signaling; TRIF-mediated programmed cell death; Regulation by c-FLIP; CASP8 activity is inhibited; Dimerization of procaspase-8; TRAIL signaling; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; TLR3-mediated TICAM1-dependent programmed cell death; TNFR1-induced proapoptotic signaling; FasL/ CD95L signaling; Defective RIPK1-mediated regulated necrosis" "33" "0" "0.983" "1.099" "1.039" "1.074" "0.918" "1.011" "1.011" "1.011" "1.020" "77.8" "76.5" "85.5" "80.8" "83.5" "71.4" "78.6" "78.7" "78.6" "79.4" "" "" "" "" "" "" "" "" "" "" "69.9" "61.9" "77.3" "78.9" "68.9" "71.4" "58.9" "69.5" "70.3" "28.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1419370867446709471" "False" "High" "IsMasterProtein" "P42677" "Small ribosomal subunit protein eS27 OS=Homo sapiens OX=9606 GN=RPS27 PE=1 SV=3" "0.000" "False" "5.136" "23" "2" "2" "2" "84" "9.5" "9.45" "6.74" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01667" "6232" "ENSG00000177954" "RPS27" "hsa:6232; P42677; Q5T4L6" "Cytoplasmic ribosomal proteins" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "25" "0" "0.977" "1.006" "1.068" "1.101" "1.023" "1.031" "1.050" "1.128" "1.071" "280.3" "273.8" "282.0" "299.3" "308.7" "286.7" "289.1" "294.3" "316.1" "300.2" "" "" "" "" "" "" "" "" "" "" "252.0" "221.5" "255.1" "292.2" "254.7" "286.7" "216.5" "259.9" "282.9" "107.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8892999754579127216" "False" "High" "IsMasterProtein" "Q96I76" "G patch domain-containing protein 3 OS=Homo sapiens OX=9606 GN=GPATCH3 PE=1 SV=1" "0.000" "False" "5.132" "4" "2" "2" "1" "525" "59.3" "5.01" "5.58" "2" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf01585" "63906" "ENSG00000198746" "GPATCH3" "hsa:63906; Q5JYH2; Q8NDJ2; Q96I76; Q9H9Z3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3115652048582382832" "False" "High" "IsMasterProtein" "Q5D1E8" "Endoribonuclease ZC3H12A OS=Homo sapiens OX=9606 GN=ZC3H12A PE=1 SV=1" "0.000" "False" "5.110" "4" "2" "2" "2" "599" "65.7" "6.93" "4.87" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf11977, Pf18039, Pf18561" "80149" "ENSG00000163874" "ZC3H12A" "D3DPT0; hsa:80149; Q5D1E8; Q6I9Z1; Q9H5P1" "IL-18 signaling pathway" "Regulation of CDH19 Expression and Function" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4369006210393907159" "False" "High" "IsMasterProtein" "Q16877" "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 OS=Homo sapiens OX=9606 GN=PFKFB4 PE=1 SV=6" "0.000" "False" "5.087" "3" "2" "3" "1" "469" "54.0" "6.62" "8.30" "2" "other metabolic processes" "cytosol" "kinase activity;other molecular function" "Pf00300, Pf01591" "5210" "ENSG00000114268" "PFKFB4" "hsa:5210; Q16877; Q5S3G5; Q5XLC2; Q64EX5" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K/AKT/mTOR - vitamin D3 signaling" "Regulation of glycolysis by fructose 2,6-bisphosphate metabolism" "3" "0" "0.991" "1.117" "0.902" "1.093" "1.114" "0.950" "0.946" "0.980" "1.019" "123.5" "122.4" "138.0" "111.4" "134.9" "137.5" "117.4" "116.9" "121.1" "125.9" "" "" "" "" "" "" "" "" "" "" "111.0" "99.0" "124.8" "108.7" "111.4" "137.5" "87.9" "103.2" "108.3" "44.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8501069546997546105" "False" "High" "IsMasterProtein" "Q8WYQ3" "Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial OS=Homo sapiens OX=9606 GN=CHCHD10 PE=1 SV=1" "0.000" "False" "5.052" "16" "1" "1" "1" "142" "14.1" "7.84" "7.44" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;mitochondrion;nucleus" "" "Pf06747" "400916" "ENSG00000250479; ENSG00000273607" "CHCHD10" "A8K0J5; hsa:400916; Q8WYQ3" "" "Mitochondrial protein import" "1" "0" "1.033" "0.945" "0.901" "1.093" "0.966" "1.005" "1.099" "1.146" "0.819" "116.2" "120.0" "109.8" "104.7" "126.9" "112.3" "116.7" "127.6" "133.1" "95.2" "" "" "" "" "" "" "" "" "" "" "104.5" "97.1" "99.3" "102.2" "104.8" "112.3" "87.4" "112.7" "119.1" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5544959501066740394" "False" "High" "IsMasterProtein" "Cont_P02666" "Beta-casein OS=Bos taurus OX=9913 GN=CSN2 PE=1 SV=2" "0.000" "True" "5.046" "7" "2" "2" "2" "224" "25.1" "5.35" "5.74" "2" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00363" "104997418; 109560545; 281099" "" "CSN2" "A0A1U9XAM2; A0A6P3I767; A1YQZ8; A6N8V0; bbis:104997418; biu:109560545; L8I8G5; P02666; Q2TA13; Q5EEQ6; Q5EEQ7; Q6UN63; Q9BDG5; Q9TSD5" "" "" "0" "0" "1.232" "0.736" "0.327" "0.794" "15.916" "0.825" "0.549" "0.887" "0.667" "12.7" "15.7" "9.4" "4.2" "10.1" "202.5" "10.5" "7.0" "11.3" "8.5" "" "" "" "" "" "" "" "" "" "" "11.4" "12.7" "8.5" "4.1" "8.3" "202.5" "7.9" "6.2" "10.1" "3.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "284975731923891311" "False" "High" "IsMasterProtein" "Q14644" "Ras GTPase-activating protein 3 OS=Homo sapiens OX=9606 GN=RASA3 PE=1 SV=3" "0.000" "False" "5.042" "2" "2" "2" "2" "834" "95.6" "7.15" "6.32" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity;enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "22821" "ENSG00000185989; ENSG00000280477" "RASA3" "A6NL15; F8W6X8; hsa:22821; Q14644; Q8IUY2" "MAPK cascade; Ras signaling; IL-18 signaling pathway" "Regulation of RAS by GAPs" "4" "0" "1.130" "0.988" "1.089" "1.182" "0.942" "1.103" "0.932" "0.935" "2.222" "91.2" "103.1" "90.1" "99.3" "107.9" "85.9" "100.6" "85.0" "85.3" "202.6" "" "" "" "" "" "" "" "" "" "" "82.0" "83.4" "81.5" "97.0" "89.0" "85.9" "75.3" "75.0" "76.3" "72.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1970257073034718295" "False" "High" "IsMasterProtein" "Q6RW13" "Type-1 angiotensin II receptor-associated protein OS=Homo sapiens OX=9606 GN=AGTRAP PE=1 SV=1" "0.000" "False" "5.023" "14" "1" "1" "1" "159" "17.4" "6.14" "5.52" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf06396" "57085" "ENSG00000177674" "AGTRAP" "A8MVQ5; hsa:57085; Q5SNV4; Q5SNV5; Q6RW13; Q96AC0; Q96PL4; Q9NRW9" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "1.525" "1.150" "0.972" "1.361" "1.358" "1.158" "1.083" "0.916" "1.039" "22.5" "34.2" "25.8" "21.8" "30.6" "30.5" "26.0" "24.3" "20.6" "23.3" "" "" "" "" "" "" "" "" "" "" "20.2" "27.7" "23.4" "21.3" "25.2" "30.5" "19.5" "21.5" "18.4" "8.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6446892440911293889" "False" "High" "IsMasterProtein" "Q5JR59" "Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens OX=9606 GN=MTUS2 PE=1 SV=3" "0.000" "False" "5.018" "1" "2" "2" "2" "1369" "150.1" "6.68" "6.39" "2" "" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "" "23281" "ENSG00000132938" "MTUS2" "A7E292; B4DF81; O94872; Q08E97; Q5JQR3; Q5JR59; Q8N5E2" "" "" "0" "0" "1.073" "1.110" "0.973" "1.092" "0.890" "1.054" "0.996" "0.821" "0.853" "158.1" "169.5" "175.5" "153.8" "172.7" "140.7" "166.6" "157.4" "129.8" "134.8" "" "" "" "" "" "" "" "" "" "" "142.1" "137.2" "158.8" "150.2" "142.5" "140.7" "124.8" "139.0" "116.2" "48.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4657566489845177469" "False" "High" "IsMasterProtein" "Q969K3" "E3 ubiquitin-protein ligase RNF34 OS=Homo sapiens OX=9606 GN=RNF34 PE=1 SV=1" "0.000" "False" "5.014" "3" "1" "1" "1" "372" "41.6" "4.96" "5.22" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf13920, Pf21272" "80196" "ENSG00000170633" "RNF34" "B7Z933; hsa:80196; Q8NG47; Q969K3; Q9H6W8" "" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of TP53 Degradation" "2" "0" "0.961" "1.031" "1.080" "1.008" "1.328" "1.103" "1.059" "1.281" "1.243" "54.7" "52.6" "56.4" "59.1" "55.2" "72.7" "60.4" "58.0" "70.1" "68.0" "" "" "" "" "" "" "" "" "" "" "49.2" "42.6" "51.0" "57.7" "45.5" "72.7" "45.2" "51.2" "62.7" "24.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2714987798271116551" "False" "High" "IsMasterProtein" "Q9BUE0" "Mediator of RNA polymerase II transcription subunit 18 OS=Homo sapiens OX=9606 GN=MED18 PE=1 SV=1" "0.000" "False" "5.014" "9" "2" "3" "2" "208" "23.6" "6.54" "9.02" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09637" "54797" "ENSG00000130772; ENSG00000284944" "MED18" "D3DPM1; hsa:54797; Q9BUE0; Q9NXU9" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.934" "1.033" "0.961" "1.029" "1.032" "0.970" "1.044" "0.968" "1.146" "402.3" "375.6" "415.4" "386.5" "414.1" "415.2" "390.1" "420.1" "389.3" "461.0" "" "" "" "" "" "" "" "" "" "" "361.7" "303.9" "375.8" "377.3" "341.7" "415.2" "292.1" "371.1" "348.4" "164.6" "3" "3" "3" "3" "3" "3" "3" "3" "3" "3" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-580971408817382446" "False" "High" "IsMasterProtein" "O75956" "Cyclin-dependent kinase 2-associated protein 2 OS=Homo sapiens OX=9606 GN=CDK2AP2 PE=1 SV=1" "0.000" "False" "5.014" "14" "2" "3" "2" "126" "13.1" "9.48" "7.02" "2" "other biological processes" "cytoskeleton;nucleus;other cell component" "" "Pf09806" "10263" "ENSG00000167797" "CDK2AP2" "hsa:10263; O75956" "" "" "0" "0" "0.770" "1.020" "0.874" "1.023" "1.219" "1.018" "0.968" "0.944" "1.664" "136.9" "105.4" "139.7" "119.6" "140.1" "166.9" "139.3" "132.5" "129.2" "227.8" "" "" "" "" "" "" "" "" "" "" "123.1" "85.3" "126.3" "116.8" "115.6" "166.9" "104.3" "117.0" "115.6" "81.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4286277691384661774" "False" "High" "IsMasterProtein" "Q6P1X5" "Transcription initiation factor TFIID subunit 2 OS=Homo sapiens OX=9606 GN=TAF2 PE=1 SV=3" "0.000" "False" "5.005" "1" "2" "2" "2" "1199" "136.9" "8.19" "5.92" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "6873" "ENSG00000064313" "TAF2" "B2RE82; hsa:6873; O43487; O43604; O60668; Q6P1X5; Q86WW7; Q8IWK4" "" "Regulation of TP53 Activity through Phosphorylation; RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation" "9" "0" "1.284" "1.210" "0.910" "1.027" "1.079" "1.052" "0.964" "1.415" "0.962" "31.4" "40.4" "38.0" "28.6" "32.3" "33.9" "33.1" "30.3" "44.5" "30.2" "" "" "" "" "" "" "" "" "" "" "28.3" "32.7" "34.4" "27.9" "26.6" "33.9" "24.8" "26.8" "39.8" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1109388387442681582" "False" "High" "IsMasterProtein" "Q9BWU1" "Cyclin-dependent kinase 19 OS=Homo sapiens OX=9606 GN=CDK19 PE=1 SV=1" "0.000" "False" "4.991" "6" "3" "3" "2" "502" "56.8" "8.53" "5.47" "3" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "23097" "ENSG00000155111" "CDK19" "hsa:23097; Q5JQZ7; Q5JR00; Q8TC78; Q9BWU1; Q9UPX2" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4099103662110185134" "False" "High" "IsMasterProtein" "Q08722" "Leukocyte surface antigen CD47 OS=Homo sapiens OX=9606 GN=CD47 PE=1 SV=1" "0.000" "False" "4.990" "6" "2" "2" "2" "323" "35.2" "7.21" "6.48" "2" "cell adhesion;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "other molecular function" "Pf04549, Pf08204" "961" "ENSG00000196776" "CD47" "A8K198; D3DN59; hsa:961; Q08722; Q53Y71; Q96A60" "Spinal cord injury; Pleural mesothelioma" "Neutrophil degranulation; Integrin cell surface interactions; Cell surface interactions at the vascular wall; Signal regulatory protein family interactions" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7897691878290275966" "False" "High" "IsMasterProtein" "Q9Y680" "Peptidyl-prolyl cis-trans isomerase FKBP7 OS=Homo sapiens OX=9606 GN=FKBP7 PE=1 SV=2" "0.000" "False" "4.982" "7" "2" "2" "2" "222" "25.8" "6.32" "5.37" "2" "protein metabolism;other metabolic processes" "ER/Golgi" "other molecular function" "Pf00254, Pf13202" "51661" "ENSG00000079150" "FKBP7" "hsa:51661; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y680; Q9Y6B0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-210569023749279335" "False" "High" "IsMasterProtein" "Q01484" "Ankyrin-2 OS=Homo sapiens OX=9606 GN=ANK2 PE=1 SV=4" "0.000" "False" "4.980" "1" "2" "2" "1" "3957" "433.4" "5.14" "5.21" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00023, Pf00531, Pf00791, Pf17809" "287" "ENSG00000145362" "ANK2" "hsa:287; Q01484; Q01485; Q08AC7; Q08AC8; Q7Z3L5" "" "Interaction between L1 and Ankyrins; COPI-mediated anterograde transport" "2" "0" "0.904" "0.777" "1.134" "0.893" "0.878" "0.866" "0.866" "0.907" "0.762" "126.8" "114.7" "98.5" "143.8" "113.3" "111.4" "109.9" "109.9" "115.1" "96.6" "" "" "" "" "" "" "" "" "" "" "114.0" "92.8" "89.1" "140.4" "93.5" "111.4" "82.3" "97.0" "103.0" "34.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2751742477750142499" "False" "High" "IsMasterProtein" "Q15345" "Leucine-rich repeat-containing protein 41 OS=Homo sapiens OX=9606 GN=LRRC41 PE=1 SV=3" "0.001" "False" "4.949" "3" "3" "3" "3" "812" "88.6" "8.38" "6.31" "3" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "" "10489" "ENSG00000132128" "LRRC41" "A8K5G8; hsa:10489; Q15345; Q3MJ96; Q5TDF5; Q71RA8; Q9BSM0" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; RHOBTB3 ATPase cycle" "3" "0" "1.204" "1.111" "0.911" "1.175" "0.979" "1.198" "1.079" "1.084" "1.049" "60.9" "73.3" "67.6" "55.4" "71.5" "59.6" "72.9" "65.7" "66.0" "63.9" "" "" "" "" "" "" "" "" "" "" "54.7" "59.3" "61.2" "54.1" "59.0" "59.6" "54.6" "58.0" "59.0" "22.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6216659800236310345" "False" "High" "IsMasterProtein" "Q9H1Z4" "WD repeat-containing protein 13 OS=Homo sapiens OX=9606 GN=WDR13 PE=1 SV=3" "0.001" "False" "4.939" "4" "1" "1" "1" "485" "53.7" "9.23" "7.00" "1" "other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus" "other molecular function" "Pf00400" "64743" "ENSG00000101940" "WDR13" "hsa:64743; Q06DW8; Q06DX0; Q06DX1; Q9BUL7; Q9H1Z4; Q9NWW4" "" "" "0" "0" "0.919" "1.074" "1.015" "1.199" "0.992" "1.248" "1.069" "0.898" "1.748" "67.1" "61.7" "72.1" "68.1" "80.5" "66.6" "83.8" "71.8" "60.3" "117.4" "" "" "" "" "" "" "" "" "" "" "60.4" "49.9" "65.2" "66.5" "66.4" "66.6" "62.7" "63.4" "53.9" "41.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7308711199030270349" "False" "High" "IsMasterProtein" "A6ND36" "Protein FAM83G OS=Homo sapiens OX=9606 GN=FAM83G PE=1 SV=2" "0.001" "False" "4.937" "2" "2" "3" "2" "823" "90.8" "6.39" "4.54" "2" "signal transduction" "cytosol;nucleus" "other molecular function" "Pf07894" "644815" "ENSG00000188522" "FAM83G" "A6ND36; hsa:644815; Q3KQZ4; Q6ZW60" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3668723528538727638" "False" "High" "IsMasterProtein" "Q9UDT6" "CAP-Gly domain-containing linker protein 2 OS=Homo sapiens OX=9606 GN=CLIP2 PE=1 SV=1" "0.001" "False" "4.935" "2" "2" "2" "1" "1046" "115.8" "6.73" "5.90" "2" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf01302" "7461" "ENSG00000106665" "CLIP2" "hsa:7461; O14527; O43611; Q9UDT6" "7q11.23 copy number variation syndrome" "" "1" "0" "1.080" "1.080" "1.007" "1.441" "0.909" "1.268" "1.021" "1.002" "1.038" "21.9" "23.6" "23.6" "22.0" "31.5" "19.9" "27.7" "22.3" "21.9" "22.7" "" "" "" "" "" "" "" "" "" "" "19.7" "19.1" "21.4" "21.5" "26.0" "19.9" "20.8" "19.7" "19.6" "8.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5520815567594939370" "False" "High" "IsMasterProtein" "O43257" "Zinc finger HIT domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT1 PE=1 SV=1" "0.001" "False" "4.932" "23" "2" "2" "2" "154" "17.5" "9.41" "6.15" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "10467" "ENSG00000106400" "ZNHIT1" "hsa:10467; O43257; Q6IB12" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2653046833350144460" "False" "High" "IsMasterProtein" "Q96JZ2" "Hematopoietic SH2 domain-containing protein OS=Homo sapiens OX=9606 GN=HSH2D PE=1 SV=1" "0.001" "False" "4.929" "6" "2" "2" "2" "352" "39.0" "7.11" "2.98" "2" "signal transduction" "nucleus;other cell component" "" "Pf00017" "84941" "ENSG00000196684" "HSH2D" "B5ME72; hsa:84941; Q6ZNG7; Q96JZ2" "" "" "0" "0" "0.885" "0.983" "0.848" "1.045" "0.847" "0.824" "0.909" "0.920" "1.336" "265.1" "234.7" "260.6" "224.8" "277.0" "224.4" "218.5" "240.8" "243.9" "354.0" "" "" "" "" "" "" "" "" "" "" "238.3" "189.9" "235.7" "219.4" "228.6" "224.4" "163.6" "212.7" "218.2" "126.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4972619903535100006" "False" "High" "IsMasterProtein" "P49916" "DNA ligase 3 OS=Homo sapiens OX=9606 GN=LIG3 PE=1 SV=2" "0.001" "False" "4.928" "2" "1" "1" "1" "1009" "112.8" "9.01" "3.56" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00645, Pf01068, Pf04675, Pf04679, Pf16759" "3980" "ENSG00000005156" "LIG3" "E5KLB5; E5KLB6; hsa:3980; P49916; Q16714; Q6NVK3" "Base excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 17q12 copy number variation syndrome" "Gap-filling DNA repair synthesis and ligation in TC-NER; APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway; HDR through MMEJ (alt-NHEJ); Resolution of AP sites via the single-nucleotide replacement pathway; Gap-filling DNA repair synthesis and ligation in GG-NER" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8001945499400243229" "False" "High" "IsMasterProtein" "Q99519" "Sialidase-1 OS=Homo sapiens OX=9606 GN=NEU1 PE=1 SV=1" "0.001" "False" "4.924" "5" "2" "2" "2" "415" "45.4" "5.88" "5.65" "2" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13088" "4758" "ENSG00000184494; ENSG00000204386; ENSG00000223957; ENSG00000227129; ENSG00000227315; ENSG00000228691; ENSG00000234343; ENSG00000234846" "NEU1" "hsa:4758; Q99519" "" "Neutrophil degranulation; Sialic acid metabolism; Glycosphingolipid catabolism; Defective NEU1 causes sialidosis" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6933895130976224833" "False" "High" "IsMasterProtein" "P23511" "Nuclear transcription factor Y subunit alpha OS=Homo sapiens OX=9606 GN=NFYA PE=1 SV=2" "0.001" "False" "4.914" "6" "1" "1" "1" "347" "36.9" "8.94" "6.47" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02045" "4800" "ENSG00000001167" "NFYA" "hsa:4800; P23511; Q8IXU0" "Sterol regulatory element-binding proteins (SREBP) signaling; Wnt signaling pathway and pluripotency; Sudden infant death syndrome (SIDS) susceptibility pathways" "PPARA activates gene expression; Activation of gene expression by SREBF (SREBP); FOXO-mediated transcription of cell death genes; ATF4 activates genes in response to endoplasmic reticulum stress; ATF6 (ATF6-alpha) activates chaperone genes" "8" "0" "1.108" "1.136" "1.458" "1.363" "1.154" "1.063" "1.516" "1.431" "0.998" "36.0" "39.9" "40.9" "52.6" "49.1" "41.6" "38.3" "54.6" "51.6" "36.0" "" "" "" "" "" "" "" "" "" "" "32.4" "32.3" "37.0" "51.3" "40.5" "41.6" "28.7" "48.3" "46.1" "12.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4864862303047708944" "False" "High" "IsMasterProtein" "P52630" "Signal transducer and activator of transcription 2 OS=Homo sapiens OX=9606 GN=STAT2 PE=1 SV=1" "0.001" "False" "4.914" "2" "2" "2" "2" "851" "97.9" "5.49" "6.30" "2" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00017, Pf01017, Pf02864, Pf02865, Pf12188, Pf21354" "6773" "ENSG00000170581" "STAT2" "B4DLC7; G3V2M6; hsa:6773; P52630; Q16430; Q16431; Q9UDL4" "Type III interferon signaling; Adipogenesis; Chemokine signaling pathway; Immune response to tuberculosis; Non-genomic actions of 1,25 dihydroxyvitamin D3; IL-10 anti-inflammatory signaling pathway ; Overview of interferons-mediated signaling pathway; Measles virus infection; Hepatitis B infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Interferon type I signaling pathways; Type II interferon signaling" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Potential therapeutics for SARS; Regulation of IFNA/IFNB signaling; Interleukin-20 family signaling; Evasion by RSV of host interferon responses" "21" "0" "1.148" "1.261" "0.915" "1.039" "1.285" "1.078" "0.923" "1.174" "2.254" "247.6" "284.2" "312.2" "226.5" "257.2" "318.2" "266.9" "228.6" "290.7" "558.2" "" "" "" "" "" "" "" "" "" "" "222.6" "230.0" "282.4" "221.1" "212.3" "318.2" "199.9" "201.9" "260.1" "199.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4617078502424805251" "False" "High" "IsMasterProtein" "Q9H857" "5'-nucleotidase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=NT5DC2 PE=1 SV=1" "0.001" "False" "4.914" "3" "2" "2" "2" "520" "60.7" "6.77" "5.52" "2" "" "" "other molecular function" "Pf05761" "64943" "ENSG00000168268" "NT5DC2" "C9JTZ6; E9PAL9; hsa:64943; O95888; Q96C80; Q9H857; Q9H9Z8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-142769344711843061" "False" "High" "IsMasterProtein" "P60468" "Protein transport protein Sec61 subunit beta OS=Homo sapiens OX=9606 GN=SEC61B PE=1 SV=2" "0.001" "False" "4.905" "22" "2" "2" "2" "96" "10.0" "11.56" "5.80" "2" "protein metabolism;other metabolic processes;stress response;transport" "other membranes;cytosol;ER/Golgi" "translation activity;other molecular function" "Pf03911" "10952" "ENSG00000106803" "SEC61B" "hsa:10952; P38390; P38391; P60468; Q6IBC1" "" "ER-Phagosome pathway; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane; SRP-dependent cotranslational protein targeting to membrane" "3" "0" "0.988" "0.990" "1.003" "0.910" "0.942" "0.850" "0.954" "0.915" "0.934" "220.8" "218.1" "218.5" "221.4" "201.0" "208.1" "187.6" "210.7" "202.0" "206.3" "" "" "" "" "" "" "" "" "" "" "198.5" "176.5" "197.7" "216.1" "165.9" "208.1" "140.5" "186.1" "180.7" "73.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4095542091731415933" "False" "High" "IsMasterProtein" "Q9HA47" "Uridine-cytidine kinase 1 OS=Homo sapiens OX=9606 GN=UCK1 PE=1 SV=1" "0.001" "False" "4.903" "5" "2" "2" "1" "277" "31.4" "7.30" "5.92" "2" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00485" "83549" "ENSG00000130717" "UCK1" "hsa:83549; Q5JT09; Q5JT10; Q5JT12; Q5JT13; Q6IA74; Q96BJ0; Q9HA47" "Fluoropyrimidine activity; Pyrimidine metabolism; IL-18 signaling pathway" "Pyrimidine salvage" "4" "0" "1.302" "1.420" "0.999" "1.239" "1.145" "1.179" "0.940" "1.365" "0.870" "128.2" "167.0" "182.1" "128.0" "158.8" "146.8" "151.2" "120.5" "175.1" "111.6" "" "" "" "" "" "" "" "" "" "" "115.3" "135.1" "164.7" "125.0" "131.1" "146.8" "113.2" "106.5" "156.7" "39.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "689463057038776482" "False" "High" "IsMasterProtein" "Q6ZS17" "Rho family-interacting cell polarization regulator 1 OS=Homo sapiens OX=9606 GN=RIPOR1 PE=1 SV=1" "0.001" "False" "4.897" "2" "2" "2" "2" "1223" "132.2" "6.28" "6.02" "2" "stress response;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf15903" "79567" "ENSG00000039523" "RIPOR1" "B4DEQ9; B4DIM2; E9PBS3; hsa:79567; Q4G0A4; Q6ZS17; Q7Z5R7; Q8NDA4; Q96J39; Q96PV8; Q9H8D9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417947325093162762" "False" "High" "IsMasterProtein" "Q49A26" "Cytokine-like nuclear factor N-PAC OS=Homo sapiens OX=9606 GN=GLYR1 PE=1 SV=4" "0.001" "False" "4.891" "3" "2" "2" "2" "553" "60.5" "9.17" "5.04" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00855, Pf03446, Pf14833" "84656" "ENSG00000140632" "GLYR1" "B4DL47; C9JJ40; C9JJ60; hsa:84656; Q49A26; Q5U632; Q6P1Q2; Q6V3W7; Q9BTI1; Q9BXK2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249500578246230084" "False" "High" "IsMasterProtein" "P09769" "Tyrosine-protein kinase Fgr OS=Homo sapiens OX=9606 GN=FGR PE=1 SV=2" "0.001" "False" "4.875" "3" "2" "4" "1" "529" "59.4" "5.59" "11.51" "2" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "2268" "ENSG00000000938" "FGR" "D3DPL7; hsa:2268; P09769; Q9UIQ3" "Focal adhesion; Chemokine signaling pathway" "FCGR activation; FCGR3A-mediated IL10 synthesis; FCGR3A-mediated phagocytosis; Neutrophil degranulation; Platelet sensitization by LDL" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8329057920573991026" "False" "High" "IsMasterProtein" "O75764" "Transcription elongation factor A protein 3 OS=Homo sapiens OX=9606 GN=TCEA3 PE=1 SV=2" "0.001" "False" "4.867" "3" "1" "2" "1" "348" "38.9" "9.19" "5.16" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01096, Pf07500, Pf08711" "6920" "ENSG00000204219; ENSG00000282941" "TCEA3" "A8K2K7; hsa:6920; O75764; Q5DR83" "" "" "0" "0" "0.939" "1.025" "0.905" "1.027" "0.971" "0.961" "1.031" "1.096" "0.989" "123.3" "115.8" "126.4" "111.5" "126.7" "119.7" "118.5" "127.2" "135.2" "121.9" "" "" "" "" "" "" "" "" "" "" "110.9" "93.7" "114.3" "108.9" "104.6" "119.7" "88.7" "112.3" "121.0" "43.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3318503761924520630" "False" "High" "IsMasterProtein" "Q96R06" "Sperm-associated antigen 5 OS=Homo sapiens OX=9606 GN=SPAG5 PE=1 SV=2" "0.001" "False" "4.855" "2" "2" "2" "2" "1193" "134.3" "5.00" "3.33" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "10615" "ENSG00000076382" "SPAG5" "hsa:10615; O95213; Q96R06; Q9BWE8; Q9NT17; Q9UFE6" "" "" "0" "0" "1.093" "0.943" "1.041" "1.068" "1.179" "0.850" "1.072" "1.120" "2.356" "54.0" "59.0" "50.9" "56.2" "57.7" "63.6" "45.9" "57.9" "60.5" "127.2" "" "" "" "" "" "" "" "" "" "" "48.5" "47.8" "46.1" "54.9" "47.6" "63.6" "34.4" "51.1" "54.1" "45.4" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6831775040715791940" "False" "High" "IsMasterProtein" "Q15043" "Metal cation symporter ZIP14 OS=Homo sapiens OX=9606 GN=SLC39A14 PE=1 SV=3" "0.001" "False" "4.849" "4" "1" "1" "1" "492" "54.2" "5.33" "5.08" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "transporter activity" "Pf02535" "23516" "ENSG00000104635" "SLC39A14" "A6NH98; B4DIW3; B6EU88; D3DSR4; hsa:23516; Q15043; Q6ZME8; Q96BB3" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis; Ferroptosis" "Zinc influx into cells by the SLC39 gene family" "5" "0" "0.893" "1.009" "1.078" "1.055" "0.995" "0.923" "1.031" "0.952" "0.714" "39.6" "35.4" "40.0" "42.7" "41.8" "39.4" "36.5" "40.9" "37.7" "28.3" "" "" "" "" "" "" "" "" "" "" "35.6" "28.6" "36.2" "41.7" "34.5" "39.4" "27.4" "36.1" "33.7" "10.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5268900827420386620" "False" "High" "IsMasterProtein" "Q96N46" "Tetratricopeptide repeat protein 14 OS=Homo sapiens OX=9606 GN=TTC14 PE=1 SV=1" "0.001" "False" "4.837" "2" "2" "2" "2" "770" "88.3" "8.63" "2.70" "2" "" "" "nucleic acid binding activity" "Pf13414" "151613" "ENSG00000163728" "TTC14" "G5E9X0; hsa:151613; Q6UWJ7; Q8TF22; Q96N46" "Ectoderm differentiation; Ectoderm differentiation" "" "2" "0" "0.864" "0.855" "0.895" "1.066" "1.185" "0.964" "0.903" "0.928" "0.903" "69.2" "59.8" "59.2" "61.9" "73.7" "82.0" "66.7" "62.5" "64.2" "62.5" "" "" "" "" "" "" "" "" "" "" "62.2" "48.4" "53.5" "60.5" "60.8" "82.0" "50.0" "55.2" "57.4" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "485577591804044204" "False" "High" "IsMasterProtein" "Q96Q45" "Transmembrane protein 237 OS=Homo sapiens OX=9606 GN=TMEM237 PE=1 SV=2" "0.001" "False" "4.832" "5" "2" "2" "2" "408" "45.5" "6.47" "5.37" "2" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf15383" "65062" "ENSG00000155755" "TMEM237" "B4E1R8; B4E2R8; E9PAR8; E9PBF8; E9PG24; E9PGX0; hsa:65062; Q53TS9; Q53TT2; Q7Z3B6; Q8IZ18; Q8NBF8; Q96CY1; Q96Q45" "Joubert syndrome; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5026099811254189140" "False" "High" "IsMasterProtein" "P11166" "Solute carrier family 2, facilitated glucose transporter member 1 OS=Homo sapiens OX=9606 GN=SLC2A1 PE=1 SV=2" "0.001" "False" "4.795" "4" "2" "2" "2" "492" "54.0" "8.72" "6.05" "2" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00083" "6513" "ENSG00000117394" "SLC2A1" "A8K9S6; B2R620; D3DPX0; hsa:6513; O75535; P11166; Q0P512; Q147X2" "Cori cycle; HIF1A and PPARG regulation of glycolysis; Nuclear receptors meta-pathway; NRF2 pathway; Photodynamic therapy-induced HIF-1 survival signaling; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Clear cell renal cell carcinoma pathways; Hereditary leiomyomatosis and renal cell carcinoma pathway; Type 2 papillary renal cell carcinoma; Metabolic reprogramming in colon cancer; Aerobic glycolysis; Insulin signaling; Proximal tubule transport; p53 transcriptional gene network; NAD metabolism in oncogene-induced senescence and mitochondrial dysfunction-associated senescence; Neuroinflammation and glutamatergic signaling; Pleural mesothelioma; Orexin receptor pathway; CCL18 signaling pathway; Glucose metabolism in triple-negative breast cancer cells; Amino acid metabolism in triple-negative breast cancer cells; Warburg effect modulated by deubiquitinating enzymes and their substrates; Chronic hyperglycemia impairment of neuron function; Glycolysis and gluconeogenesis; Macrophage-stimulating protein (MSP) signaling network map; Metabolic Epileptic Disorders; Pancreatic cancer subtypes; 15q25 copy number variation; GLP-1 in pancreatic islet cells; GLP-1 from intestine and pancreas and role in glucose homeostasis" "Cellular hexose transport; Regulation of insulin secretion; Vitamin C (ascorbate) metabolism; Lactose synthesis; Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)" "36" "0" "0.914" "0.713" "0.871" "0.889" "0.824" "1.016" "1.108" "0.824" "0.788" "64.5" "59.0" "46.0" "56.2" "57.4" "53.2" "65.6" "71.5" "53.2" "50.8" "" "" "" "" "" "" "" "" "" "" "58.0" "47.7" "41.6" "54.9" "47.4" "53.2" "49.1" "63.2" "47.6" "18.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7444310123710857374" "False" "High" "IsMasterProtein" "Q9Y2Y9" "Krueppel-like factor 13 OS=Homo sapiens OX=9606 GN=KLF13 PE=1 SV=1" "0.001" "False" "4.764" "7" "1" "1" "1" "288" "31.2" "9.54" "6.32" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "51621" "ENSG00000169926; ENSG00000275746" "KLF13" "hsa:51621; Q9Y2Y9; Q9Y356" "15q13.3 copy number variation syndrome; 15q11q13 copy number variation" "" "2" "0" "0.957" "0.717" "0.902" "0.922" "0.904" "0.938" "0.943" "0.811" "1.067" "101.3" "97.0" "72.7" "91.4" "93.4" "91.6" "95.1" "95.6" "82.2" "108.2" "" "" "" "" "" "" "" "" "" "" "91.1" "78.5" "65.7" "89.2" "77.1" "91.6" "71.2" "84.4" "73.6" "38.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4045429465415994492" "False" "High" "IsMasterProtein" "Q3ZCQ8" "Mitochondrial import inner membrane translocase subunit TIM50 OS=Homo sapiens OX=9606 GN=TIMM50 PE=1 SV=2" "0.001" "False" "4.763" "3" "1" "2" "1" "353" "39.6" "8.37" "11.26" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;signal transduction" "other membranes;mitochondrion;nucleus" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf03031" "92609" "ENSG00000105197" "TIMM50" "hsa:92609; Q330K1; Q3ZCQ8; Q6QA00; Q96FJ5; Q96GY2; Q9H370" "" "Mitochondrial protein import" "1" "0" "1.259" "1.065" "1.095" "0.996" "1.066" "1.444" "1.334" "1.004" "0.759" "43.7" "55.0" "46.6" "47.9" "43.6" "46.6" "63.1" "58.3" "43.9" "33.2" "" "" "" "" "" "" "" "" "" "" "39.3" "44.5" "42.1" "46.7" "35.9" "46.6" "47.3" "51.5" "39.3" "11.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3278874134147621934" "False" "High" "IsMasterProtein" "P51451" "Tyrosine-protein kinase Blk OS=Homo sapiens OX=9606 GN=BLK PE=1 SV=3" "0.001" "False" "4.757" "3" "2" "4" "1" "505" "57.7" "7.87" "12.48" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714" "640" "ENSG00000136573; ENSG00000285369" "BLK" "hsa:640; P51451; Q16291; Q96IN1" "B cell receptor signaling pathway; Focal adhesion; Genes associated with the development of rheumatoid arthritis; 8p23.1 copy number variation syndrome" "Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; RUNX1 regulates transcription of genes involved in BCR signaling" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9173522146093415156" "False" "High" "IsMasterProtein" "Q9P0J7" "E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens OX=9606 GN=KCMF1 PE=1 SV=2" "0.001" "False" "4.755" "5" "2" "3" "2" "381" "41.9" "5.66" "9.91" "2" "cell-cell signaling" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "other molecular function" "Pf00569, Pf05605" "56888" "ENSG00000176407" "KCMF1" "Q4ZG04; Q53SC7; Q9BWK2; Q9H8P5; Q9P0J7; Q9UFE8" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5207099841471329802" "False" "High" "IsMasterProtein" "A4D1S5" "Ras-related protein Rab-19 OS=Homo sapiens OX=9606 GN=RAB19 PE=1 SV=2" "0.001" "False" "4.746" "5" "1" "2" "1" "217" "24.4" "6.52" "6.23" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00071" "401409" "ENSG00000146955" "RAB19" "A4D1S5; A4D1S6; B2RTS6; B5MDR2; hsa:401409; Q9UL27" "" "RAB geranylgeranylation" "1" "0" "0.857" "0.901" "0.571" "0.745" "0.633" "0.727" "0.739" "0.674" "0.544" "71.9" "61.6" "64.8" "41.0" "53.6" "45.5" "52.3" "53.1" "48.5" "39.1" "" "" "" "" "" "" "" "" "" "" "64.7" "49.9" "58.6" "40.1" "44.2" "45.5" "39.2" "46.9" "43.4" "14.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1127806469772618408" "False" "High" "IsMasterProtein" "Q9Y4D8" "Probable E3 ubiquitin-protein ligase HECTD4 OS=Homo sapiens OX=9606 GN=HECTD4 PE=1 SV=5" "0.001" "False" "4.742" "1" "2" "2" "2" "3996" "439.1" "6.19" "2.42" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf00632" "" "" "HECTD4" "L8B0P6; Q3MJD5; Q6P0A0; Q7L530; Q8NB70; Q8WU73; Q96NT9; Q9NZS4; Q9UFT6; Q9Y4D8" "" "" "0" "0" "0.881" "1.218" "0.772" "0.814" "0.976" "0.790" "0.872" "0.737" "1.154" "137.6" "121.2" "167.6" "106.2" "111.9" "134.2" "108.7" "119.9" "101.4" "158.8" "" "" "" "" "" "" "" "" "" "" "123.7" "98.1" "151.6" "103.6" "92.4" "134.2" "81.4" "105.9" "90.7" "56.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3643630707960143102" "False" "High" "IsMasterProtein" "Q4KWH8" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 OS=Homo sapiens OX=9606 GN=PLCH1 PE=1 SV=1" "0.001" "False" "4.739" "0" "1" "5" "1" "1693" "189.1" "7.74" "15.86" "1" "other metabolic processes;transport;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf09279, Pf16457" "23007" "ENSG00000114805" "PLCH1" "hsa:23007; Q29RV9; Q4KWH8; Q4KWH9; Q68CN0; Q86XK4; Q9H9U2; Q9UPT3" "Mesodermal commitment pathway; GPR40 pathway" "Synthesis of IP3 and IP4 in the cytosol" "3" "0" "0.936" "0.915" "0.840" "0.939" "0.777" "1.005" "0.937" "0.957" "0.631" "638.2" "597.3" "583.9" "536.4" "599.1" "495.9" "641.6" "597.9" "610.6" "402.7" "" "" "" "" "" "" "" "" "" "" "573.8" "483.3" "528.2" "523.6" "494.4" "495.9" "480.4" "528.1" "546.4" "143.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1779891872713868152" "False" "High" "IsMasterProtein" "Q9UMX1" "Suppressor of fused homolog OS=Homo sapiens OX=9606 GN=SUFU PE=1 SV=2" "0.001" "False" "4.729" "3" "2" "2" "2" "484" "53.9" "5.33" "6.31" "2" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05076, Pf12470" "51684" "ENSG00000107882" "SUFU" "hsa:51684; Q7LCP7; Q9NT90; Q9NZ07; Q9UHK2; Q9UHM8; Q9UMX1; Q9UMY0" "Hedgehog signaling pathway; Joubert syndrome; Hedgehog signaling pathway; Ciliopathies; Bardet-Biedl syndrome" "Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1709691025135321684" "False" "High" "IsMasterProtein" "O00499" "Myc box-dependent-interacting protein 1 OS=Homo sapiens OX=9606 GN=BIN1 PE=1 SV=1" "0.001" "False" "4.724" "4" "2" "2" "2" "593" "64.7" "5.06" "5.00" "2" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf03114, Pf14604" "274" "ENSG00000136717" "BIN1" "hsa:274; O00297; O00499; O00545; O43867; O60552; O60553; O60554; O60555; O75514; O75515; O75516; O75517; O75518; Q659B7; Q92944; Q99688" "VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Clathrin-mediated endocytosis" "3" "0" "0.937" "0.949" "0.781" "0.994" "0.934" "1.007" "0.893" "1.008" "0.959" "101.9" "95.4" "96.8" "79.6" "101.3" "95.2" "102.7" "91.0" "102.7" "97.7" "" "" "" "" "" "" "" "" "" "" "91.6" "77.2" "87.5" "77.7" "83.6" "95.2" "76.9" "80.3" "91.9" "34.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8564322409184755345" "False" "High" "IsMasterProtein" "Q9Y4K3" "TNF receptor-associated factor 6 OS=Homo sapiens OX=9606 GN=TRAF6 PE=1 SV=1" "0.001" "False" "4.721" "3" "2" "2" "2" "522" "59.5" "6.44" "5.59" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf13923, Pf18048, Pf21355" "7189" "ENSG00000175104" "TRAF6" "A6NKI7; A8KAB3; D3DR16; hsa:7189; Q8NEH5; Q9Y4K3" "IL-1 signaling pathway; RANKL/RANK signaling pathway; IL-17 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Melatonin metabolism and effects; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NF-kB survival signaling; Interleukin-1 induced activation of NF-kB; TGF-beta signaling pathway; MAPK signaling pathway; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; MYD88 distinct input-output pathway; ApoE and miR-146 in inflammation and atherosclerosis; Oxidative damage response; Fibrin complement receptor 3 signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; miRNA role in immune response in sepsis; LTF danger signal response pathway; Signal transduction through IL1R; Interactions between immune cells and microRNAs in tumor microenvironment; Measles virus infection; Small cell lung cancer; Hepatitis B infection; IL-18 signaling pathway; Autosomal recessive osteopetrosis pathways; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; 16p11.2 proximal deletion syndrome; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Modulators of TCR signaling and T cell activation; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; Clock-controlled autophagy in bone metabolism; Induction of autophagy and toll-like receptor signaling pathways by graphene oxide ; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "Ub-specific processing proteases; FCERI mediated NF-kB activation; Downstream TCR signaling; CLEC7A (Dectin-1) signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; PIP3 activates AKT signaling; IKK complex recruitment mediated by RIP1; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; p75NTR recruits signalling complexes; NF-kB is activated and signals survival; TAK1-dependent IKK and NF-kappa-B activation ; TRAF6 mediated NF-kB activation; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; TICAM1,TRAF6-dependent induction of TAK1 complex; activated TAK1 mediates p38 MAPK activation; IRAK2 mediated activation of TAK1 complex; SARS-CoV-1 activates/modulates innate immune responses; Alpha-protein kinase 1 signaling pathway; Ovarian tumor domain proteases; TRAF6 mediated IRF7 activation; NRIF signals cell death from the nucleus; Regulated proteolysis of p75NTR; TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" "78" "0" "1.258" "1.303" "1.349" "1.513" "1.240" "1.738" "1.364" "1.105" "0.557" "13.6" "17.1" "17.7" "18.3" "20.6" "16.9" "23.6" "18.5" "15.0" "7.6" "" "" "" "" "" "" "" "" "" "" "12.2" "13.8" "16.0" "17.9" "17.0" "16.9" "17.7" "16.4" "13.4" "2.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8619075754329803082" "False" "High" "IsMasterProtein" "P17275" "Transcription factor JunB OS=Homo sapiens OX=9606 GN=JUNB PE=1 SV=1" "0.001" "False" "4.720" "5" "2" "3" "2" "347" "35.9" "9.22" "10.18" "2" "cell cycle OR cell proliferation;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170, Pf03957" "3726" "ENSG00000171223" "JUNB" "hsa:3726; P17275; Q96GH3" "Corticotropin-releasing hormone signaling pathway; Oncostatin M signaling pathway; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Kit receptor signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; IL6 signaling pathway; TGF-beta signaling pathway; Oxidative stress response; Host-pathogen interaction of human coronaviruses - MAPK signaling; Overlap between signal transduction pathways contributing to LMNA laminopathies; Orexin receptor pathway; Osteoarthritic chondrocyte hypertrophy" "SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; NGF-stimulated transcription; Interleukin-4 and Interleukin-13 signaling; Nuclear events stimulated by ALK signaling in cancer" "18" "0" "1.112" "1.632" "1.081" "1.017" "1.677" "1.114" "1.166" "1.766" "1.139" "195.4" "217.3" "318.9" "211.2" "198.6" "327.6" "217.7" "227.9" "344.9" "222.6" "" "" "" "" "" "" "" "" "" "" "175.6" "175.8" "288.5" "206.1" "163.9" "327.6" "163.0" "201.3" "308.6" "79.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "935705506060532462" "False" "High" "IsMasterProtein" "A0A0U1RRE5" "Negative regulator of P-body association OS=Homo sapiens OX=9606 GN=NBDY PE=1 SV=1" "0.001" "False" "4.714" "25" "2" "5" "2" "68" "7.0" "9.42" "7.82" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other cell component" "" "" "550643" "ENSG00000204272" "NBDY" "A0A0U1RRE5" "" "" "0" "0" "1.136" "1.132" "1.038" "1.084" "1.122" "1.105" "1.199" "1.171" "1.065" "167.2" "190.0" "189.3" "173.5" "181.2" "187.6" "184.8" "200.4" "195.8" "178.1" "" "" "" "" "" "" "" "" "" "" "150.3" "153.7" "171.3" "169.4" "149.5" "187.6" "138.4" "177.0" "175.2" "63.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1559309219543781640" "False" "High" "IsMasterProtein" "Cont_Q1WEI2" "Protease IV OS=Pseudomonas aeruginosa OX=287 GN=prpL PE=4 SV=1" "0.001" "True" "4.703" "6" "1" "1" "1" "462" "48.2" "7.08" "5.54" "1" "protein metabolism" "" "other molecular function" "" "" "" "prpL" "Q1WEI2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1654139714091192156" "False" "High" "IsMasterProtein" "P56181" "NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFV3 PE=1 SV=2" "0.001" "False" "4.702" "15" "1" "1" "1" "108" "11.9" "9.70" "5.79" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf15880" "4731" "ENSG00000160194" "NDUFV3" "A8K0M1; hsa:4731; J3KNX7; P56181; Q6FGD3; Q8WU60; Q9HCR5" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "0.908" "1.204" "1.221" "1.206" "1.123" "0.971" "1.192" "1.315" "0.635" "108.7" "98.7" "130.9" "132.8" "131.1" "122.1" "105.6" "129.6" "143.0" "69.1" "" "" "" "" "" "" "" "" "" "" "97.8" "79.9" "118.4" "129.6" "108.2" "122.1" "79.1" "114.5" "127.9" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "843171063376576291" "False" "High" "IsMasterProtein" "Q6P0Q8" "Microtubule-associated serine/threonine-protein kinase 2 OS=Homo sapiens OX=9606 GN=MAST2 PE=1 SV=2" "0.001" "False" "4.687" "1" "2" "3" "1" "1798" "196.3" "8.16" "7.00" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;kinase activity;other molecular function" "Pf00069, Pf08926, Pf17820" "23139" "ENSG00000086015" "MAST2" "hsa:23139; O94899; Q5VT07; Q5VT08; Q6P0Q8; Q7LGC4; Q8NDG1; Q96B94; Q9BYE8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2227436002470218796" "False" "High" "IsMasterProtein" "P05141" "ADP/ATP translocase 2 OS=Homo sapiens OX=9606 GN=SLC25A5 PE=1 SV=7" "0.001" "False" "4.673" "4" "1" "1" "1" "298" "32.8" "9.69" "4.75" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;mitochondrion" "transporter activity;other molecular function" "Pf00153" "292" "ENSG00000005022" "SLC25A5" "B2RCV1; hsa:292; O43350; P05141" "Electron transport chain: OXPHOS system in mitochondria; Alzheimer's disease and miRNA effects; Alzheimer's disease" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Mitochondrial protein degradation; Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization" "6" "0" "0.834" "0.726" "0.825" "0.812" "0.799" "1.180" "0.816" "0.860" "0.739" "57.0" "47.5" "41.3" "47.0" "46.2" "45.5" "67.2" "46.5" "49.0" "42.1" "" "" "" "" "" "" "" "" "" "" "51.2" "38.4" "37.4" "45.9" "38.2" "45.5" "50.3" "41.0" "43.9" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6379952211340011163" "False" "High" "IsMasterProtein" "Q96CJ1" "ELL-associated factor 2 OS=Homo sapiens OX=9606 GN=EAF2 PE=1 SV=1" "0.001" "False" "4.668" "7" "2" "2" "2" "260" "28.8" "5.17" "6.73" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf09816" "55840" "ENSG00000145088" "EAF2" "hsa:55840; Q96CJ1; Q9NZ82" "" "Formation of RNA Pol II elongation complex ; RNA Polymerase II Pre-transcription Events" "3" "0" "1.092" "1.136" "1.069" "1.089" "1.209" "1.007" "1.029" "1.183" "1.880" "144.1" "157.3" "163.7" "154.0" "156.8" "174.1" "145.0" "148.3" "170.4" "270.8" "" "" "" "" "" "" "" "" "" "" "129.5" "127.2" "148.0" "150.3" "129.4" "174.1" "108.6" "131.0" "152.5" "96.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5598137855594202811" "False" "High" "IsMasterProtein" "Q9Y6G3" "Large ribosomal subunit protein mL42 OS=Homo sapiens OX=9606 GN=MRPL42 PE=1 SV=1" "0.001" "False" "4.656" "16" "1" "1" "1" "142" "16.7" "8.35" "4.81" "1" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf10210" "28977" "ENSG00000198015" "MRPL42" "hsa:28977; Q6FID1; Q96Q48; Q9P0S1; Q9Y6G3" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.955" "0.970" "0.777" "0.811" "0.728" "0.782" "0.971" "0.783" "0.539" "20.2" "19.3" "19.6" "15.7" "16.4" "14.7" "15.8" "19.6" "15.8" "10.9" "" "" "" "" "" "" "" "" "" "" "18.2" "15.6" "17.7" "15.3" "13.5" "14.7" "11.8" "17.3" "14.2" "3.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9084351700158867792" "False" "High" "IsMasterProtein" "Q9HD33" "Large ribosomal subunit protein uL29m OS=Homo sapiens OX=9606 GN=MRPL47 PE=1 SV=2" "0.001" "False" "4.653" "7" "2" "3" "2" "250" "29.4" "10.37" "6.04" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf06984" "57129" "ENSG00000136522" "MRPL47" "hsa:57129; Q6XRG1; Q8N5D1; Q9HD33" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1736895483408566633" "False" "High" "IsMasterProtein" "Cont_Q62168" "Keratin, type I cuticular Ha2 OS=Mus musculus OX=10090 GN=Krt32 PE=1 SV=2" "0.001" "True" "4.650" "5" "3" "3" "1" "407" "46.4" "4.82" "7.26" "3" "cell organization and biogenesis;other biological processes" "cytoskeleton" "other molecular function" "Pf00038" "16670" "" "Krt32" "mmu:16670; Q148N4; Q62168" "" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3279265676386753137" "False" "High" "IsMasterProtein" "Q9BXB4" "Oxysterol-binding protein-related protein 11 OS=Homo sapiens OX=9606 GN=OSBPL11 PE=1 SV=2" "0.001" "False" "4.648" "3" "2" "2" "1" "747" "83.6" "7.06" "5.38" "2" "transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114885" "ENSG00000144909" "OSBPL11" "A8K9I7; hsa:114885; Q9BXB4" "" "RHOH GTPase cycle" "1" "1" "0.614" "1.429" "0.719" "0.767" "0.755" "0.780" "0.435" "0.552" "4.108" "65.0" "39.9" "92.9" "46.8" "49.8" "49.1" "50.7" "28.3" "35.9" "267.0" "" "" "" "" "" "" "" "" "" "" "58.4" "32.3" "84.0" "45.6" "41.1" "49.1" "38.0" "25.0" "32.1" "95.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2682194375242126200" "False" "High" "IsMasterProtein" "P04114" "Apolipoprotein B-100 OS=Homo sapiens OX=9606 GN=APOB PE=1 SV=3" "0.001" "False" "4.646" "0" "2" "2" "1" "4563" "515.2" "7.05" "6.09" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf01347, Pf06448, Pf09172, Pf12491" "338" "ENSG00000084674" "APOB" "hsa:338; O00502; P04114; P78479; P78480; P78481; Q13779; Q13785; Q13786; Q13787; Q13788; Q4ZG63; Q53QC8; Q7Z600; Q9UMN0" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Statin inhibition of cholesterol production; Male infertility; Perturbations to host-cell autophagy, induced by SARS-CoV-2 proteins; Familial hyperlipidemia type 2; Cholesterol metabolism; Female steroid hormones in cardiomyocyte energy metabolism; Fatty acids and lipoproteins transport in hepatocytes; Enterocyte cholesterol metabolism" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Cargo recognition for clathrin-mediated endocytosis; Cell surface interactions at the vascular wall; Scavenging by Class B Receptors; Regulation of TLR by endogenous ligand; Heme signaling; Retinoid metabolism and transport; LDL clearance; Chylomicron clearance; Scavenging by Class A Receptors; Chylomicron assembly; Chylomicron remodeling; VLDL assembly; VLDL clearance; Scavenging by Class F Receptors; Scavenging by Class H Receptors; Platelet sensitization by LDL; LDL remodeling" "31" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4099473831415028291" "False" "High" "IsMasterProtein" "Q15011" "Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein OS=Homo sapiens OX=9606 GN=HERPUD1 PE=1 SV=1" "0.001" "False" "4.643" "6" "2" "2" "2" "391" "43.7" "5.25" "5.17" "2" "protein metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00240" "9709" "ENSG00000051108" "HERPUD1" "E9PGD1; hsa:9709; O60644; Q15011; Q6IAN8; Q96D92" "VEGFA-VEGFR2 signaling; Exercise-induced circadian regulation" "ATF4 activates genes in response to endoplasmic reticulum stress" "3" "0" "0.962" "1.003" "0.922" "1.017" "1.043" "1.046" "1.005" "0.939" "0.941" "186.5" "179.3" "187.0" "172.0" "189.6" "194.5" "195.0" "187.3" "175.0" "175.5" "" "" "" "" "" "" "" "" "" "" "167.7" "145.1" "169.2" "167.9" "156.5" "194.5" "146.0" "165.5" "156.6" "62.7" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7322827353079219364" "False" "High" "IsMasterProtein" "Q68DH5" "G-protein coupled receptor-associated protein LMBRD2 OS=Homo sapiens OX=9606 GN=LMBRD2 PE=1 SV=1" "0.001" "False" "4.631" "2" "1" "1" "1" "695" "81.1" "7.50" "4.12" "1" "signal transduction" "plasma membrane;other membranes" "" "Pf04791" "92255" "ENSG00000164187" "LMBRD2" "B3KRB6; hsa:92255; Q68DH5; Q9NTC7" "" "" "0" "0" "1.090" "0.978" "0.932" "1.047" "0.905" "1.010" "1.067" "1.057" "1.127" "66.2" "72.2" "64.7" "61.7" "69.3" "59.9" "66.9" "70.7" "70.0" "74.7" "" "" "" "" "" "" "" "" "" "" "59.5" "58.4" "58.6" "60.2" "57.2" "59.9" "50.1" "62.4" "62.7" "26.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5229500280398030060" "False" "High" "IsMasterProtein" "Q9Y2E5" "Epididymis-specific alpha-mannosidase OS=Homo sapiens OX=9606 GN=MAN2B2 PE=1 SV=4" "0.001" "False" "4.629" "2" "2" "2" "2" "1009" "113.9" "7.24" "2.64" "2" "other metabolic processes" "other cytoplasmic organelle" "other molecular function" "Pf01074, Pf07748, Pf09261" "23324" "ENSG00000013288" "MAN2B2" "hsa:23324; Q66MP2; Q86T67; Q9Y2E5" "" "Lysosomal oligosaccharide catabolism" "1" "0" "1.249" "1.099" "0.918" "1.272" "1.156" "1.309" "1.206" "1.155" "1.041" "118.7" "148.2" "130.4" "108.9" "150.9" "137.2" "155.4" "143.1" "137.0" "123.5" "" "" "" "" "" "" "" "" "" "" "106.7" "119.9" "117.9" "106.3" "124.6" "137.2" "116.3" "126.4" "122.6" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7073332157955076013" "False" "High" "IsMasterProtein" "P50914" "Large ribosomal subunit protein eL14 OS=Homo sapiens OX=9606 GN=RPL14 PE=1 SV=4" "0.001" "False" "4.618" "9" "2" "3" "2" "215" "23.4" "10.93" "6.86" "2" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01929" "9045" "ENSG00000188846" "RPL14" "hsa:9045; P50914; Q45RF0; Q53G20; Q8TBD5; Q8WUT0; Q92579; Q96GR0; Q9BSB8; Q9BW65; Q9BYF6" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.699" "0.575" "0.880" "0.761" "0.894" "0.649" "0.702" "0.932" "0.481" "41.6" "29.1" "23.9" "36.6" "31.7" "37.2" "27.0" "29.2" "38.8" "20.0" "" "" "" "" "" "" "" "" "" "" "37.4" "23.5" "21.6" "35.8" "26.1" "37.2" "20.2" "25.8" "34.7" "7.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5086527343524186673" "False" "High" "IsMasterProtein" "Q9UH36" "SRR1-like protein OS=Homo sapiens OX=9606 GN=SRRD PE=1 SV=1" "0.001" "False" "4.611" "4" "1" "1" "1" "339" "38.5" "5.41" "5.40" "1" "other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf07985" "402055" "ENSG00000100104" "SRRD" "hsa:402055; Q6NXP8; Q9UH36" "" "" "0" "0" "1.093" "0.963" "1.127" "1.216" "0.888" "1.118" "1.285" "0.912" "0.871" "54.7" "59.8" "52.7" "61.6" "66.5" "48.6" "61.1" "70.3" "49.9" "47.6" "" "" "" "" "" "" "" "" "" "" "49.2" "48.4" "47.7" "60.2" "54.9" "48.6" "45.8" "62.1" "44.6" "17.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3088066192462104792" "False" "High" "IsMasterProtein" "O15534" "Period circadian protein homolog 1 OS=Homo sapiens OX=9606 GN=PER1 PE=1 SV=2" "0.001" "False" "4.608" "1" "2" "2" "2" "1290" "136.1" "6.09" "5.41" "2" "cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08447, Pf12114, Pf21353" "5187" "ENSG00000179094" "PER1" "B2RPA8; B4DI49; D3DTR3; hsa:5187; O15534" "Melatonin metabolism and effects; Exercise-induced circadian regulation; Th17 cell differentiation pathway; Clock-controlled autophagy in bone metabolism; NF1 copy number variation syndrome ; Smith-Magenis and Potocki-Lupski syndrome copy number variation" "Circadian Clock" "7" "0" "1.027" "1.131" "0.835" "1.220" "1.078" "1.098" "1.147" "1.094" "0.927" "158.6" "162.8" "179.3" "132.5" "193.5" "171.0" "174.1" "182.0" "173.5" "147.0" "" "" "" "" "" "" "" "" "" "" "142.6" "131.8" "162.2" "129.3" "159.7" "171.0" "130.4" "160.7" "155.2" "52.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3490991347050641114" "False" "High" "IsMasterProtein" "Q9H9A7" "RecQ-mediated genome instability protein 1 OS=Homo sapiens OX=9606 GN=RMI1 PE=1 SV=3" "0.001" "False" "4.597" "3" "1" "1" "1" "625" "70.1" "4.96" "4.94" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf08585, Pf16099, Pf21000" "80010" "ENSG00000178966" "RMI1" "hsa:80010; Q05BX1; Q05CW3; Q5SQG8; Q5SQG9; Q6P1Q4; Q6PI89; Q7Z6L6; Q9H9A7" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-344337871911847900" "False" "High" "IsMasterProtein" "Q86X53" "Glutamate-rich protein 1 OS=Homo sapiens OX=9606 GN=ERICH1 PE=1 SV=1" "0.001" "False" "4.595" "3" "1" "1" "1" "443" "49.0" "4.78" "4.63" "1" "" "" "" "" "157697" "ENSG00000104714" "ERICH1" "A8K2J9; hsa:157697; Q86X53; Q9P063" "" "" "0" "0" "1.056" "0.790" "0.968" "1.024" "0.993" "0.923" "1.008" "0.744" "2.558" "96.6" "101.9" "76.3" "93.5" "98.9" "95.9" "89.2" "97.3" "71.8" "247.0" "" "" "" "" "" "" "" "" "" "" "86.8" "82.5" "69.0" "91.2" "81.6" "95.9" "66.8" "86.0" "64.2" "88.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1389983804562693885" "False" "High" "IsMasterProtein" "A2RUC4" "tRNA wybutosine-synthesizing protein 5 OS=Homo sapiens OX=9606 GN=TYW5 PE=1 SV=1" "0.001" "False" "4.594" "5" "2" "2" "2" "315" "36.5" "7.55" "6.21" "2" "RNA metabolism OR transcription;other metabolic processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf13621" "129450" "ENSG00000162971" "TYW5" "A2RUC4; B2RNE3; hsa:129450; Q8N1R2" "" "Synthesis of wybutosine at G37 of tRNA(Phe)" "1" "0" "1.147" "1.076" "1.048" "1.175" "1.032" "1.051" "1.076" "1.007" "1.134" "185.6" "212.9" "199.6" "194.4" "218.0" "191.4" "195.0" "199.6" "186.9" "210.5" "" "" "" "" "" "" "" "" "" "" "166.8" "172.2" "180.5" "189.8" "179.9" "191.4" "146.0" "176.3" "167.2" "75.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1292677114640833852" "False" "High" "IsMasterProtein" "Q5VZL5" "Zinc finger MYM-type protein 4 OS=Homo sapiens OX=9606 GN=ZMYM4 PE=1 SV=1" "0.001" "False" "4.583" "2" "3" "3" "3" "1548" "172.7" "6.84" "4.33" "3" "cell organization and biogenesis;other biological processes" "" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9202" "ENSG00000146463" "ZMYM4" "A0JP19; A0JP20; hsa:9202; O43308; Q5T5E1; Q5T5E2; Q5VZL5; Q7L3Q4" "" "" "0" "0" "1.006" "0.926" "0.839" "1.089" "0.903" "0.925" "1.059" "1.036" "0.803" "40.2" "40.4" "37.2" "33.7" "43.8" "36.3" "37.2" "42.6" "41.6" "32.3" "" "" "" "" "" "" "" "" "" "" "36.1" "32.7" "33.7" "32.9" "36.1" "36.3" "27.9" "37.6" "37.3" "11.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-760926983399472078" "False" "High" "IsMasterProtein" "P57060" "RWD domain-containing protein 2B OS=Homo sapiens OX=9606 GN=RWDD2B PE=1 SV=1" "0.001" "False" "4.579" "5" "1" "1" "1" "319" "36.3" "5.87" "5.20" "1" "" "" "" "Pf05773, Pf06544" "10069" "ENSG00000156253; ENSG00000291523" "RWDD2B" "hsa:10069; P57060" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7097092162087690863" "False" "High" "IsMasterProtein" "O43683" "Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens OX=9606 GN=BUB1 PE=1 SV=1" "0.001" "False" "4.577" "2" "2" "2" "2" "1085" "122.3" "6.47" "4.85" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069, Pf08311" "699" "ENSG00000169679" "BUB1" "E9PC26; F5GXI5; hsa:699; O43430; O43643; O43683; O60626; Q53QE4" "Cell cycle; ATM signaling in development and disease ; Regulation of sister chromatid separation at the metaphase-anaphase transition" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "9" "0" "0.858" "0.897" "0.809" "1.014" "0.865" "0.895" "0.944" "0.841" "2.087" "68.4" "58.7" "61.4" "55.3" "69.4" "59.2" "61.3" "64.6" "57.6" "142.8" "" "" "" "" "" "" "" "" "" "" "61.5" "47.5" "55.5" "54.0" "57.3" "59.2" "45.9" "57.0" "51.5" "51.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1365521486549272318" "False" "High" "IsMasterProtein" "Q6ICB0" "Desumoylating isopeptidase 1 OS=Homo sapiens OX=9606 GN=DESI1 PE=1 SV=1" "0.001" "False" "4.577" "10" "2" "2" "2" "168" "18.3" "4.94" "6.55" "2" "protein metabolism;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05903" "27351" "ENSG00000100418" "DESI1" "hsa:27351; Q6ICB0" "" "" "0" "0" "0.922" "1.030" "1.008" "1.002" "0.999" "0.931" "0.977" "0.982" "2.000" "259.5" "239.3" "267.2" "261.6" "260.0" "259.2" "241.6" "253.6" "254.9" "519.1" "" "" "" "" "" "" "" "" "" "" "233.3" "193.7" "241.7" "255.4" "214.5" "259.2" "180.9" "224.0" "228.1" "185.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8961190954250988131" "False" "High" "IsMasterProtein" "Q16891" "MICOS complex subunit MIC60 OS=Homo sapiens OX=9606 GN=IMMT PE=1 SV=1" "0.001" "False" "4.561" "3" "3" "3" "3" "758" "83.6" "6.48" "5.66" "3" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09731" "10989" "ENSG00000132305" "IMMT" "B1H0U5; B2R5N6; hsa:10989; Q14539; Q15092; Q16891; Q68D41; Q69HW5; Q6IBL0; Q7Z3X1; Q8TAJ5; Q9P0V2" "" "Cristae formation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1630467620585670619" "False" "High" "IsMasterProtein" "Q9Y6K1" "DNA (cytosine-5)-methyltransferase 3A OS=Homo sapiens OX=9606 GN=DNMT3A PE=1 SV=4" "0.001" "False" "4.553" "2" "1" "1" "1" "912" "101.8" "6.57" "5.48" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00145, Pf00855, Pf17980, Pf21255" "1788" "ENSG00000119772" "DNMT3A" "E9PEB8; hsa:1788; Q86TE8; Q86XF5; Q8IZV0; Q8WXU9; Q9Y6K1" "One-carbon metabolism; Trans-sulfuration, one-carbon metabolism and related pathways; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; One-carbon metabolism and related pathways; MTHFR deficiency; Opioid receptor pathways; Spina bifida" "RMTs methylate histone arginines; PRC2 methylates histones and DNA; Defective pyroptosis; DNA methylation; SUMOylation of DNA methylation proteins" "12" "0" "1.580" "1.358" "1.094" "1.225" "1.356" "1.241" "1.684" "1.122" "2.159" "13.4" "21.1" "18.1" "14.6" "16.4" "18.1" "16.6" "22.5" "15.0" "28.8" "" "" "" "" "" "" "" "" "" "" "12.0" "17.1" "16.4" "14.3" "13.5" "18.1" "12.4" "19.9" "13.4" "10.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2076182377996629975" "False" "High" "IsMasterProtein" "Q9H8U3" "AN1-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=ZFAND3 PE=1 SV=1" "0.001" "False" "4.544" "7" "1" "1" "1" "227" "25.2" "7.43" "4.80" "1" "" "" "nucleic acid binding activity;other molecular function" "Pf01428, Pf01754" "60685" "ENSG00000156639" "ZFAND3" "hsa:60685; Q5SZZ0; Q5SZZ1; Q9H8U3" "" "" "0" "0" "1.074" "1.136" "1.224" "1.410" "1.146" "1.060" "1.228" "1.140" "0.989" "55.3" "59.4" "62.8" "67.7" "78.0" "63.4" "58.6" "67.9" "63.0" "54.7" "" "" "" "" "" "" "" "" "" "" "49.7" "48.0" "56.8" "66.1" "64.3" "63.4" "43.9" "60.0" "56.4" "19.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5703387660850171759" "False" "High" "IsMasterProtein" "O95900" "Pseudouridylate synthase TRUB2, mitochondrial OS=Homo sapiens OX=9606 GN=TRUB2 PE=1 SV=1" "0.001" "False" "4.517" "5" "2" "2" "1" "331" "36.7" "8.98" "5.20" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf01509" "26995" "ENSG00000167112" "TRUB2" "B7Z7G5; hsa:26995; O95900" "" "" "0" "0" "1.063" "1.015" "0.992" "1.026" "0.957" "1.002" "1.060" "0.878" "1.863" "66.5" "70.7" "67.5" "66.0" "68.3" "63.7" "66.7" "70.5" "58.4" "123.9" "" "" "" "" "" "" "" "" "" "" "59.8" "57.2" "61.1" "64.4" "56.3" "63.7" "49.9" "62.3" "52.3" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8337602067628073965" "False" "High" "IsMasterProtein" "O00159" "Unconventional myosin-Ic OS=Homo sapiens OX=9606 GN=MYO1C PE=1 SV=4" "0.001" "False" "4.516" "1" "2" "2" "2" "1063" "121.6" "9.41" "6.15" "2" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4641" "ENSG00000197879" "MYO1C" "hsa:4641; O00159; Q4LE56; Q6NVJ7; Q86Y95" "VEGFA-VEGFR2 signaling; Insulin signaling; 10q11.21q11.23 copy number variation syndrome" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Translocation of SLC2A4 (GLUT4) to the plasma membrane" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "621836974049986451" "False" "High" "IsMasterProtein" "Q9Y3E7" "Charged multivesicular body protein 3 OS=Homo sapiens OX=9606 GN=CHMP3 PE=1 SV=3" "0.001" "False" "4.514" "7" "2" "2" "2" "222" "25.1" "5.12" "6.52" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf03357" "100526767; 51652" "ENSG00000115561" "CHMP3" "A8K3W0; B4DG34; B8ZZM0; B8ZZX5; hsa:100526767; hsa:51652; Q3ZTS9; Q53S71; Q53SU5; Q9NZ51; Q9Y3E7" "" "Budding and maturation of HIV virion; Endosomal Sorting Complex Required For Transport (ESCRT); HCMV Late Events; Late endosomal microautophagy; Sealing of the nuclear envelope (NE) by ESCRT-III; Macroautophagy; Pyroptosis; Translation of Replicase and Assembly of the Replication Transcription Complex; Translation of Replicase and Assembly of the Replication Transcription Complex" "9" "0" "0.943" "0.993" "0.889" "1.123" "0.991" "1.002" "1.028" "1.071" "0.890" "321.9" "303.7" "319.5" "286.3" "361.6" "318.8" "322.4" "330.9" "344.6" "286.4" "" "" "" "" "" "" "" "" "" "" "289.4" "245.7" "289.0" "279.4" "298.4" "318.8" "241.4" "292.3" "308.3" "102.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2098721597077854322" "False" "High" "IsMasterProtein" "Q9NTJ4" "Alpha-mannosidase 2C1 OS=Homo sapiens OX=9606 GN=MAN2C1 PE=1 SV=1" "0.001" "False" "4.508" "2" "1" "1" "1" "1040" "115.8" "6.57" "4.38" "1" "other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf01074, Pf07748, Pf09261, Pf17677" "4123" "ENSG00000140400" "MAN2C1" "H3BMX2; H3BQY8; H3BUT6; hsa:4123; Q13358; Q68EM8; Q9NTJ4; Q9UL64" "" "Lysosomal oligosaccharide catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2285465926165935505" "False" "High" "IsMasterProtein" "Q8WVN8" "Ubiquitin-conjugating enzyme E2 Q2 OS=Homo sapiens OX=9606 GN=UBE2Q2 PE=1 SV=1" "0.001" "False" "4.505" "5" "2" "2" "1" "375" "42.8" "4.96" "5.31" "2" "protein metabolism;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00179, Pf05773" "92912" "ENSG00000140367" "UBE2Q2" "B7Z3Q2; H3BRG2; hsa:92912; Q8N4G6; Q8WVN8; Q96J08" "" "Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation" "2" "0" "1.038" "1.025" "0.936" "1.055" "0.904" "1.103" "1.049" "1.169" "1.361" "92.8" "96.3" "95.0" "86.8" "97.8" "83.9" "102.3" "97.3" "108.5" "126.2" "" "" "" "" "" "" "" "" "" "" "83.4" "77.9" "86.0" "84.8" "80.7" "83.9" "76.6" "85.9" "97.1" "45.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3666835465541347575" "False" "High" "IsMasterProtein" "Q14684" "Ribosomal RNA processing protein 1 homolog B OS=Homo sapiens OX=9606 GN=RRP1B PE=1 SV=3" "0.001" "False" "4.504" "3" "2" "2" "2" "758" "84.4" "9.76" "6.28" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf05997" "23076" "ENSG00000160208" "RRP1B" "hsa:23076; Q14684; Q8TBZ4" "" "" "0" "0" "1.003" "0.926" "1.065" "1.074" "1.055" "1.006" "0.896" "0.916" "1.076" "165.7" "166.1" "153.5" "176.4" "177.9" "174.8" "166.7" "148.5" "151.8" "178.3" "" "" "" "" "" "" "" "" "" "" "148.9" "134.4" "138.8" "172.2" "146.8" "174.8" "124.8" "131.1" "135.8" "63.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "654723519218057862" "False" "High" "IsMasterProtein" "Q9BXB5" "Oxysterol-binding protein-related protein 10 OS=Homo sapiens OX=9606 GN=OSBPL10 PE=1 SV=2" "0.001" "False" "4.489" "3" "2" "2" "1" "764" "83.9" "8.31" "5.48" "2" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "114884" "ENSG00000144645" "OSBPL10" "B4E212; hsa:114884; Q9BTU5; Q9BXB5" "" "Acyl chain remodelling of PS" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8713380436033100522" "False" "High" "IsMasterProtein" "Q71SY5" "Mediator of RNA polymerase II transcription subunit 25 OS=Homo sapiens OX=9606 GN=MED25 PE=1 SV=2" "0.001" "False" "4.483" "2" "1" "1" "1" "747" "78.1" "8.34" "5.69" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf11232, Pf11235, Pf11265" "81857" "ENSG00000104973" "MED25" "A8K095; B9TX30; hsa:81857; O95783; Q6P143; Q6QMH5; Q707U4; Q71SY5; Q8TB55; Q9H0L5; Q9HB34" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-662349959999439869" "False" "High" "IsMasterProtein" "Q92871" "Phosphomannomutase 1 OS=Homo sapiens OX=9606 GN=PMM1 PE=1 SV=2" "0.001" "False" "4.474" "9" "2" "2" "2" "262" "29.7" "5.74" "4.92" "2" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf03332" "5372" "ENSG00000100417" "PMM1" "A8K003; hsa:5372; Q92586; Q92871" "" "Synthesis of GDP-mannose" "1" "0" "1.067" "1.334" "1.067" "0.982" "1.322" "1.223" "0.872" "1.141" "1.112" "59.7" "63.7" "79.6" "63.7" "58.6" "78.9" "73.0" "52.0" "68.1" "66.4" "" "" "" "" "" "" "" "" "" "" "53.7" "51.5" "72.0" "62.2" "48.4" "78.9" "54.7" "46.0" "61.0" "23.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3394977433117342737" "False" "High" "IsMasterProtein" "Q92859" "Neogenin OS=Homo sapiens OX=9606 GN=NEO1 PE=1 SV=2" "0.001" "False" "4.472" "2" "2" "2" "2" "1461" "159.9" "6.54" "5.66" "2" "cell adhesion;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00041, Pf06583, Pf07679, Pf13895, Pf13927" "4756" "ENSG00000067141" "NEO1" "B7ZKM9; B7ZKN0; hsa:4756; O00340; Q17RX1; Q92859" "Splicing factor NOVA regulated synaptic proteins; Netrin-UNC5B signaling pathway; 10q11.21q11.23 copy number variation syndrome" "Myogenesis; Netrin-1 signaling" "5" "0" "0.941" "1.098" "0.944" "1.024" "0.962" "0.974" "1.006" "1.023" "0.754" "48.0" "45.2" "52.7" "45.3" "49.2" "46.2" "46.8" "48.3" "49.1" "36.2" "" "" "" "" "" "" "" "" "" "" "43.2" "36.5" "47.7" "44.2" "40.6" "46.2" "35.0" "42.7" "43.9" "12.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9163044576809599647" "False" "High" "IsMasterProtein" "P0DPB6" "DNA-directed RNA polymerases I and III subunit RPAC2 OS=Homo sapiens OX=9606 GN=POLR1D PE=1 SV=1" "0.001" "False" "4.466" "11" "1" "1" "1" "133" "15.2" "5.80" "5.05" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf01193, Pf13656" "51082" "ENSG00000186184" "POLR1D" "hsa:51082; P0DPB6; Q5TBX2; Q96BR3; Q9Y2S0" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-781411655815037660" "False" "High" "IsMasterProtein" "P14316" "Interferon regulatory factor 2 OS=Homo sapiens OX=9606 GN=IRF2 PE=1 SV=2" "0.001" "False" "4.460" "5" "2" "2" "2" "349" "39.3" "7.52" "4.85" "2" "cell cycle OR cell proliferation;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00605" "3660" "ENSG00000168310" "IRF2" "D6RCK5; H0Y8S3; hsa:3660; P14316; Q6IAS7; Q96B99" "Apoptosis; Rubinstein-Taybi syndrome 1; Type II interferon signaling" "Interferon gamma signaling; Factors involved in megakaryocyte development and platelet production; Interferon alpha/beta signaling; Pyroptosis" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-644613747775713736" "False" "High" "IsMasterProtein" "Q9UIL1" "Short coiled-coil protein OS=Homo sapiens OX=9606 GN=SCOC PE=1 SV=2" "0.001" "False" "4.455" "11" "1" "1" "1" "159" "18.0" "8.85" "5.50" "1" "other biological processes" "other membranes;cytosol;ER/Golgi;nucleus" "" "Pf10224" "60592" "ENSG00000153130" "SCOC" "B7WPH7; D3DNY7; E9PB65; hsa:60592; Q6P5T9; Q7L2Y0; Q7Z4P2; Q96JY9; Q9BZB2; Q9UIL1" "" "Retrograde transport at the Trans-Golgi-Network" "1" "0" "0.957" "0.999" "0.768" "0.852" "0.857" "0.929" "0.930" "0.886" "0.513" "49.8" "47.7" "49.8" "38.3" "42.5" "42.7" "46.3" "46.3" "44.1" "25.6" "" "" "" "" "" "" "" "" "" "" "44.8" "38.6" "45.0" "37.4" "35.0" "42.7" "34.6" "40.9" "39.5" "9.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8718473415120973367" "False" "High" "IsMasterProtein" "O00462" "Beta-mannosidase OS=Homo sapiens OX=9606 GN=MANBA PE=1 SV=3" "0.001" "False" "4.448" "2" "2" "3" "1" "879" "100.8" "5.52" "5.68" "2" "protein metabolism;other metabolic processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf02836, Pf17753, Pf17786" "4126" "ENSG00000109323" "MANBA" "hsa:4126; O00462; Q96BC3; Q9NYX9" "" "Neutrophil degranulation; Lysosomal oligosaccharide catabolism" "2" "0" "0.911" "0.714" "0.678" "0.965" "0.870" "1.106" "0.942" "0.778" "0.786" "71.8" "65.4" "51.2" "48.6" "69.3" "62.4" "79.4" "67.6" "55.9" "56.4" "" "" "" "" "" "" "" "" "" "" "64.5" "52.9" "46.3" "47.5" "57.2" "62.4" "59.5" "59.7" "50.0" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4622932999208517122" "False" "High" "IsMasterProtein" "Q96HR8" "H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Homo sapiens OX=9606 GN=NAF1 PE=1 SV=2" "0.001" "False" "4.444" "4" "2" "2" "2" "494" "53.7" "4.87" "6.33" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04410" "92345" "ENSG00000145414" "NAF1" "D3DP28; E9PAZ2; hsa:92345; Q96HR8" "" "" "0" "0" "0.923" "1.072" "0.981" "0.983" "1.017" "1.029" "0.952" "0.924" "1.288" "107.5" "99.3" "115.3" "105.5" "105.7" "109.3" "110.7" "102.4" "99.3" "138.5" "" "" "" "" "" "" "" "" "" "" "96.7" "80.4" "104.3" "103.0" "87.2" "109.3" "82.9" "90.5" "88.9" "49.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1475037397769826540" "False" "High" "IsMasterProtein" "O75817" "Ribonuclease P protein subunit p20 OS=Homo sapiens OX=9606 GN=POP7 PE=1 SV=2" "0.001" "False" "4.439" "11" "1" "1" "1" "140" "15.6" "8.94" "4.40" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf12328" "10248" "ENSG00000172336" "POP7" "A4D2E0; hsa:10248; O75817; Q9BV74" "" "tRNA processing in the nucleus" "1" "0" "0.878" "0.867" "0.828" "0.819" "0.935" "0.867" "0.746" "0.863" "1.098" "59.0" "51.8" "51.2" "48.9" "48.3" "55.2" "51.1" "44.0" "50.9" "64.8" "" "" "" "" "" "" "" "" "" "" "53.0" "41.9" "46.3" "47.7" "39.8" "55.2" "38.3" "38.8" "45.5" "23.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "545380139494389775" "False" "High" "IsMasterProtein" "P08962" "CD63 antigen OS=Homo sapiens OX=9606 GN=CD63 PE=1 SV=2" "0.001" "False" "4.433" "8" "2" "2" "2" "238" "25.6" "7.81" "6.56" "2" "cell adhesion;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00335" "967" "ENSG00000135404" "CD63" "F8VZE2; hsa:967; P08962; Q5TZP3; Q8N6Z9; Q9UCG6" "Extracellular vesicles in the crosstalk of cardiac cells; 11p11.2 copy number variation syndrome" "Neutrophil degranulation; Platelet degranulation" "4" "0" "0.904" "0.948" "0.998" "0.926" "0.974" "0.798" "0.910" "1.072" "0.901" "145.3" "131.4" "137.8" "145.0" "134.5" "141.5" "116.0" "132.3" "155.7" "130.9" "" "" "" "" "" "" "" "" "" "" "130.7" "106.3" "124.7" "141.6" "111.0" "141.5" "86.9" "116.8" "139.3" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4545350310808249062" "False" "High" "IsMasterProtein" "Q4AE62" "tRNA-queuosine alpha-mannosyltransferase OS=Homo sapiens OX=9606 GN=GTDC1 PE=1 SV=1" "0.001" "False" "4.430" "3" "2" "2" "2" "458" "52.6" "7.25" "6.47" "2" "" "" "other molecular function" "Pf00534, Pf12038" "79712" "ENSG00000121964" "GTDC1" "A0A087X2H5; A8K5P2; D3DP81; G1UFN1; G5EA49; H7BYJ5; hsa:79712; Q4AE62; Q53SM7; Q53TC5; Q6P7E7; Q6PJB6; Q6WKW6; Q9HAE5" "" "" "0" "0" "1.025" "0.897" "0.973" "1.043" "0.976" "0.944" "1.002" "1.026" "0.925" "342.2" "350.8" "306.9" "332.8" "357.1" "334.1" "323.0" "342.8" "351.0" "316.7" "" "" "" "" "" "" "" "" "" "" "307.7" "283.9" "277.6" "324.9" "294.7" "334.1" "241.9" "302.8" "314.1" "113.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7308252133513090836" "False" "High" "IsMasterProtein" "O14907" "Tax1-binding protein 3 OS=Homo sapiens OX=9606 GN=TAX1BP3 PE=1 SV=2" "0.001" "False" "4.415" "14" "1" "1" "1" "124" "13.7" "8.48" "4.89" "1" "cell-cell signaling;protein metabolism;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00595" "30851" "ENSG00000213977" "TAX1BP3" "B2RD53; D3DTJ6; hsa:30851; O14907; Q7LCQ4" "" "RHO GTPases Activate Rhotekin and Rhophilins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "407060077554528043" "False" "High" "IsMasterProtein" "Q5T3I0" "G patch domain-containing protein 4 OS=Homo sapiens OX=9606 GN=GPATCH4 PE=1 SV=2" "0.001" "False" "4.414" "4" "1" "1" "1" "446" "50.4" "9.63" "4.74" "1" "" "nucleus" "" "Pf01585" "" "ENSG00000292251" "GPATCH4" "Q5T3I0; Q5T3I1; Q6ZUE7; Q8IWG8; Q9NXH4" "" "" "0" "0" "1.092" "1.093" "1.148" "1.173" "1.157" "1.178" "1.165" "1.012" "1.289" "72.2" "78.8" "78.9" "82.9" "84.7" "83.5" "85.0" "84.1" "73.1" "93.1" "" "" "" "" "" "" "" "" "" "" "64.9" "63.8" "71.4" "80.9" "69.9" "83.5" "63.7" "74.3" "65.4" "33.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5572152547917971737" "False" "High" "IsMasterProtein" "Q5T3J3" "Ligand-dependent nuclear receptor-interacting factor 1 OS=Homo sapiens OX=9606 GN=LRIF1 PE=1 SV=1" "0.001" "False" "4.402" "2" "1" "1" "1" "769" "84.5" "9.72" "3.80" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;nucleus" "other molecular function" "Pf15741" "55791" "ENSG00000121931" "LRIF1" "hsa:55791; Q5T3J3; Q86XS4; Q8N3B6; Q96HT4; Q9NUM5; Q9NV32" "" "" "0" "0" "1.061" "0.922" "0.822" "0.748" "0.882" "0.966" "1.054" "0.876" "1.133" "21.4" "22.7" "19.7" "17.6" "16.0" "18.9" "20.7" "22.6" "18.8" "24.2" "" "" "" "" "" "" "" "" "" "" "19.2" "18.4" "17.9" "17.2" "13.2" "18.9" "15.5" "19.9" "16.8" "8.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4845069297566421061" "False" "High" "IsMasterProtein" "P35221" "Catenin alpha-1 OS=Homo sapiens OX=9606 GN=CTNNA1 PE=1 SV=1" "0.001" "False" "4.402" "2" "2" "2" "2" "906" "100.0" "6.29" "4.60" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01044" "1495" "ENSG00000044115" "CTNNA1" "hsa:1495; P35221; Q12795; Q8N1C0" "Arrhythmogenic right ventricular cardiomyopathy; Apoptosis-related network due to altered Notch3 in ovarian cancer; VEGFA-VEGFR2 signaling; White fat cell differentiation; Endometrial cancer; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "RHO GTPases activate IQGAPs; Myogenesis; VEGFR2 mediated vascular permeability; Adherens junctions interactions; Regulation of CDH11 function; Regulation of CDH19 Expression and Function; CDH11 homotypic and heterotypic interactions" "15" "0" "0.991" "1.061" "0.960" "0.997" "1.071" "1.016" "1.011" "1.186" "0.985" "184.3" "182.6" "195.4" "176.9" "183.8" "197.4" "187.2" "186.3" "218.5" "181.4" "" "" "" "" "" "" "" "" "" "" "165.7" "147.7" "176.8" "172.7" "151.6" "197.4" "140.2" "164.5" "195.5" "64.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7680065627734331684" "False" "High" "IsMasterProtein" "Q3KRA6" "UPF0538 protein C2orf76 OS=Homo sapiens OX=9606 GN=C2orf76 PE=1 SV=3" "0.001" "False" "4.388" "10" "1" "2" "1" "126" "14.6" "6.93" "7.33" "1" "" "" "" "Pf10209" "130355" "ENSG00000186132" "C2orf76" "B7ZLS8; hsa:130355; Q3KRA6; Q4VC35" "" "" "0" "0" "0.956" "0.957" "0.881" "1.046" "0.917" "1.066" "0.871" "1.001" "1.013" "118.8" "113.5" "113.7" "104.7" "124.3" "108.9" "126.7" "103.5" "118.9" "120.4" "" "" "" "" "" "" "" "" "" "" "106.8" "91.9" "102.9" "102.2" "102.5" "108.9" "94.8" "91.4" "106.4" "43.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6167412320153067815" "False" "High" "IsMasterProtein" "P35613" "Basigin OS=Homo sapiens OX=9606 GN=BSG PE=1 SV=2" "0.001" "False" "4.378" "7" "2" "2" "2" "385" "42.2" "5.66" "5.88" "2" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13927" "682" "ENSG00000172270" "BSG" "A6NJW1; D3YLG5; hsa:682; P35613; Q7Z796; Q8IZL7" "Matrix metalloproteinases; VEGFA-VEGFR2 signaling; IL-18 signaling pathway" "Degradation of the extracellular matrix; Integrin cell surface interactions; Pyruvate metabolism; Aspirin ADME; Basigin interactions; Proton-coupled monocarboxylate transport; Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)" "10" "0" "0.959" "1.041" "1.093" "1.026" "0.936" "0.966" "0.981" "1.085" "0.677" "324.8" "311.4" "338.2" "354.9" "333.3" "303.9" "313.6" "318.5" "352.3" "220.0" "" "" "" "" "" "" "" "" "" "" "292.0" "252.0" "306.0" "346.4" "275.0" "303.9" "234.8" "281.4" "315.3" "78.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108137657648573585" "False" "High" "IsMasterProtein" "O95571" "Persulfide dioxygenase ETHE1, mitochondrial OS=Homo sapiens OX=9606 GN=ETHE1 PE=1 SV=2" "0.001" "False" "4.370" "6" "1" "1" "1" "254" "27.9" "6.83" "4.87" "1" "other metabolic processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00753" "23474" "ENSG00000105755" "ETHE1" "hsa:23474; O95571; Q96HR0; Q9H001" "" "Sulfide oxidation to sulfate" "1" "0" "0.951" "0.925" "0.976" "0.923" "0.976" "0.935" "0.983" "0.889" "0.780" "108.1" "102.8" "100.0" "105.5" "99.8" "105.5" "101.1" "106.3" "96.1" "84.3" "" "" "" "" "" "" "" "" "" "" "97.2" "83.2" "90.5" "103.0" "82.4" "105.5" "75.7" "93.9" "86.0" "30.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2518500882063606702" "False" "High" "IsMasterProtein" "Q13164" "Mitogen-activated protein kinase 7 OS=Homo sapiens OX=9606 GN=MAPK7 PE=1 SV=2" "0.001" "False" "4.367" "2" "2" "2" "1" "816" "88.3" "5.88" "5.36" "2" "cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5598" "ENSG00000166484" "MAPK7" "hsa:5598; Q13164; Q16634; Q59F50; Q6QLU7; Q7L4P4; Q969G1; Q96G51" "MicroRNAs in cardiomyocyte hypertrophy; Integrin-mediated cell adhesion; Brain-derived neurotrophic factor (BDNF) signaling pathway; S1P receptor signal transduction; Cardiac hypertrophic response; MAPK signaling pathway; Angiopoietin-like protein 8 regulatory pathway; Embryonic stem cell pluripotency pathways; Non-genomic actions of 1,25 dihydroxyvitamin D3; EGF/EGFR signaling pathway; Osteoblast differentiation and related diseases; Insulin signaling; Pleural mesothelioma; GDNF signaling" "Senescence-Associated Secretory Phenotype (SASP); RET signaling; Gastrin-CREB signalling pathway via PKC and MAPK; ERKs are inactivated; Signalling to ERK5" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8871370198028658557" "False" "High" "IsMasterProtein" "P62995" "Transformer-2 protein homolog beta OS=Homo sapiens OX=9606 GN=TRA2B PE=1 SV=1" "0.001" "False" "4.357" "6" "2" "2" "2" "288" "33.6" "11.25" "5.07" "2" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "6434" "ENSG00000136527" "TRA2B" "B4DVK2; D3DNU3; hsa:6434; O15449; P62995; Q15815; Q64283" "mRNA processing" "mRNA Splicing - Major Pathway; Processing of Capped Intron-Containing Pre-mRNA; RHOBTB2 GTPase cycle; RHOBTB1 GTPase cycle" "5" "0" "0.865" "0.690" "0.918" "0.896" "0.688" "0.739" "0.782" "0.858" "1.084" "169.1" "146.2" "116.6" "155.2" "151.6" "116.3" "125.0" "132.2" "145.0" "183.3" "" "" "" "" "" "" "" "" "" "" "152.0" "118.3" "105.5" "151.5" "125.1" "116.3" "93.6" "116.8" "129.7" "65.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6507776403363592543" "False" "High" "IsMasterProtein" "O94985" "Calsyntenin-1 OS=Homo sapiens OX=9606 GN=CLSTN1 PE=1 SV=1" "0.001" "False" "4.350" "1" "1" "1" "1" "981" "109.7" "4.91" "3.86" "1" "cell adhesion;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00028, Pf13385, Pf19699" "22883" "ENSG00000171603" "CLSTN1" "A8K183; hsa:22883; O94985; Q5SR52; Q5UE58; Q71MN0; Q8N4K9" "Splicing factor NOVA regulated synaptic proteins" "" "1" "0" "1.122" "0.886" "0.924" "1.209" "1.077" "1.041" "0.921" "0.960" "0.761" "65.2" "73.1" "57.8" "60.3" "78.8" "70.2" "67.8" "60.0" "62.6" "49.6" "" "" "" "" "" "" "" "" "" "" "58.6" "59.2" "52.3" "58.8" "65.0" "70.2" "50.8" "53.0" "56.0" "17.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8083299006508235950" "False" "High" "IsMasterProtein" "O94761" "ATP-dependent DNA helicase Q4 OS=Homo sapiens OX=9606 GN=RECQL4 PE=1 SV=2" "0.001" "False" "4.349" "1" "1" "1" "1" "1208" "133.0" "8.09" "4.77" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf11719" "9401" "ENSG00000160957" "RECQL4" "A0A087WZ30; hsa:9401; O94761; Q3Y424; Q96DW2; Q96F55" "Primary ovarian insufficiency" "" "1" "0" "0.841" "0.983" "0.874" "0.850" "0.876" "1.000" "0.704" "0.727" "1.448" "27.5" "23.1" "27.0" "24.0" "23.4" "24.1" "27.5" "19.3" "20.0" "39.8" "" "" "" "" "" "" "" "" "" "" "24.7" "18.7" "24.4" "23.4" "19.3" "24.1" "20.6" "17.1" "17.9" "14.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3737855785058777273" "False" "High" "IsMasterProtein" "Q9NSP4" "Centromere protein M OS=Homo sapiens OX=9606 GN=CENPM PE=1 SV=1" "0.001" "False" "4.338" "6" "1" "2" "1" "180" "19.7" "7.20" "9.71" "1" "cell cycle OR cell proliferation" "cytosol;nucleus;other cell component" "" "Pf11111" "79019" "ENSG00000100162" "CENPM" "A7LM22; B1AHQ9; hsa:79019; Q6I9W3; Q9NSP4" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "1.102" "1.102" "0.900" "1.121" "1.069" "1.098" "0.981" "1.053" "1.384" "272.9" "300.9" "300.8" "245.7" "305.8" "291.6" "299.7" "267.7" "287.5" "377.6" "" "" "" "" "" "" "" "" "" "" "245.4" "243.4" "272.1" "239.8" "252.3" "291.6" "224.4" "236.4" "257.2" "134.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4566145074236190376" "False" "High" "IsMasterProtein" "P15289" "Arylsulfatase A OS=Homo sapiens OX=9606 GN=ARSA PE=1 SV=3" "0.001" "False" "4.330" "3" "1" "2" "1" "507" "53.6" "6.07" "7.88" "1" "other metabolic processes" "non-structural extracellular;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00884, Pf14707" "410" "ENSG00000100299" "ARSA" "B2RCA6; B7XD04; F8WCC8; hsa:410; P15289; Q6ICI5; Q96CJ0" "Degradation pathway of sphingolipids, including diseases" "Neutrophil degranulation; Glycosphingolipid catabolism; The activation of arylsulfatases" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7865485040516399738" "False" "High" "IsMasterProtein" "P78536" "Disintegrin and metalloproteinase domain-containing protein 17 OS=Homo sapiens OX=9606 GN=ADAM17 PE=1 SV=1" "0.001" "False" "4.329" "2" "1" "2" "1" "824" "93.0" "5.76" "7.79" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00200, Pf13574, Pf16698" "6868" "ENSG00000151694" "ADAM17" "hsa:6868; O60226; P78536" "Alzheimer's disease and miRNA effects; Brain-derived neurotrophic factor (BDNF) signaling pathway; Notch signaling; Copper homeostasis; Ebola virus infection in host; Soluble ACE2-mediated cell entry of SARS-CoV-2; Interactions of natural killer cells in pancreatic cancer; Alzheimer's disease; TROP2 regulatory signaling; Notch signaling pathway" "Collagen degradation; Release of Hh-Np from the secreting cell; Activated NOTCH1 Transmits Signal to the Nucleus; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant; Growth hormone receptor signaling; Nuclear signaling by ERBB4; Signaling by EGFR; TNF signaling; CD163 mediating an anti-inflammatory response; Regulated proteolysis of p75NTR" "23" "0" "0.979" "1.010" "1.192" "1.101" "1.000" "1.069" "1.017" "0.998" "0.903" "138.4" "135.5" "139.8" "164.9" "152.4" "138.4" "147.9" "140.7" "138.0" "124.9" "" "" "" "" "" "" "" "" "" "" "124.4" "109.6" "126.4" "161.0" "125.7" "138.4" "110.8" "124.3" "123.5" "44.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1010665989767425721" "False" "High" "IsMasterProtein" "Q96CS3" "FAS-associated factor 2 OS=Homo sapiens OX=9606 GN=FAF2 PE=1 SV=2" "0.001" "False" "4.314" "4" "1" "1" "1" "445" "52.6" "5.62" "5.60" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport" "non-structural extracellular;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00789, Pf14555, Pf21021" "23197" "ENSG00000113194" "FAF2" "hsa:23197; O94963; Q8IUF2; Q96CS3; Q9BRP2; Q9BVM7" "5q35 copy number variation" "Neutrophil degranulation; RHOA GTPase cycle" "3" "0" "1.152" "0.939" "1.087" "1.201" "0.990" "1.132" "1.053" "1.102" "0.798" "61.7" "71.1" "57.9" "67.1" "74.1" "61.1" "69.8" "65.0" "68.0" "49.3" "" "" "" "" "" "" "" "" "" "" "55.5" "57.6" "52.4" "65.5" "61.2" "61.1" "52.3" "57.4" "60.8" "17.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2125908269399926840" "False" "High" "IsMasterProtein" "Q9UKK3" "Protein mono-ADP-ribosyltransferase PARP4 OS=Homo sapiens OX=9606 GN=PARP4 PE=1 SV=3" "0.001" "False" "4.312" "1" "2" "2" "2" "1724" "192.5" "5.66" "5.02" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00092, Pf00533, Pf00644, Pf08487" "143" "ENSG00000102699" "PARP4" "hsa:143; O75903; Q14682; Q5QNZ9; Q9H1M6; Q9UKK3" "NAD+ biosynthetic pathways; 16p11.2 proximal deletion syndrome" "Maturation of nucleoprotein; Nicotinamide salvaging; Maturation of nucleoprotein" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8885735133454120700" "False" "High" "IsMasterProtein" "Q13277" "Syntaxin-3 OS=Homo sapiens OX=9606 GN=STX3 PE=1 SV=3" "0.001" "False" "4.310" "6" "2" "2" "2" "289" "33.1" "5.44" "4.95" "2" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00804, Pf05739" "6809" "ENSG00000166900" "STX3" "B4DME0; hsa:6809; O43750; O43751; Q13277; Q15360" "Synaptic vesicle pathway" "Other interleukin signaling" "2" "0" "1.041" "1.077" "1.062" "1.192" "1.183" "1.185" "1.123" "1.046" "1.107" "86.2" "89.7" "92.8" "91.5" "102.7" "101.9" "102.1" "96.8" "90.1" "95.4" "" "" "" "" "" "" "" "" "" "" "77.5" "72.5" "84.0" "89.3" "84.8" "101.9" "76.5" "85.5" "80.6" "34.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4762125104752177783" "False" "High" "IsMasterProtein" "A0JNW5" "Bridge-like lipid transfer protein family member 3B OS=Homo sapiens OX=9606 GN=BLTP3B PE=1 SV=2" "0.001" "False" "4.301" "2" "2" "2" "2" "1464" "164.1" "6.32" "3.43" "2" "cell organization and biogenesis;transport" "cytosol;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf12624" "23074" "ENSG00000111647" "BLTP3B" "A0JNW5; A0PJE5; hsa:23074; O75183; Q8NDL1; Q96C30; Q9BTS5; Q9H0F1" "" "RND2 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "614531152509290275" "False" "High" "IsMasterProtein" "Q9BRD0" "BUD13 homolog OS=Homo sapiens OX=9606 GN=BUD13 PE=1 SV=1" "0.001" "False" "4.294" "2" "1" "1" "1" "619" "70.5" "9.86" "4.47" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf09736" "84811" "ENSG00000137656" "BUD13" "A8K0S0; hsa:84811; Q96LS7; Q9BRD0" "" "mRNA Splicing - Major Pathway" "1" "0" "0.981" "0.981" "1.068" "0.988" "1.028" "0.931" "0.888" "0.858" "0.762" "137.0" "134.4" "134.4" "146.2" "135.4" "140.8" "127.5" "121.6" "117.6" "104.4" "" "" "" "" "" "" "" "" "" "" "123.1" "108.8" "121.6" "142.8" "111.7" "140.8" "95.5" "107.4" "105.2" "37.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8184691105517631334" "False" "High" "IsMasterProtein" "Q9P035" "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2" "0.001" "False" "4.290" "3" "1" "1" "1" "362" "43.1" "8.94" "4.64" "1" "other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus" "enzyme regulator activity;other molecular function" "Pf04387" "51495" "ENSG00000074696" "HACD3" "A0PJA1; B4DRF4; hsa:51495; Q280Z3; Q6PD63; Q8IUI5; Q8NC86; Q8NCB1; Q96T12; Q9NQA7; Q9P035" "" "Synthesis of very long-chain fatty acyl-CoAs" "1" "0" "0.979" "0.892" "1.029" "1.054" "0.830" "1.042" "0.949" "0.990" "0.525" "88.7" "86.8" "79.0" "91.3" "93.4" "73.6" "92.4" "84.1" "87.7" "46.6" "" "" "" "" "" "" "" "" "" "" "79.7" "70.2" "71.5" "89.1" "77.1" "73.6" "69.2" "74.3" "78.5" "16.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "370234138651289741" "False" "High" "IsMasterProtein" "Q96RS0" "Trimethylguanosine synthase OS=Homo sapiens OX=9606 GN=TGS1 PE=1 SV=3" "0.001" "False" "4.280" "3" "1" "1" "1" "853" "96.6" "4.94" "4.09" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf09445" "96764" "ENSG00000137574" "TGS1" "A6NJQ5; hsa:96764; Q5GH23; Q8TDG9; Q96QU3; Q96RS0; Q9H5V3" "" "Heme signaling; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Transcriptional activation of mitochondrial biogenesis; Cytoprotection by HMOX1; Activation of gene expression by SREBF (SREBP); RORA activates gene expression; snRNP Assembly" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6327174108011486304" "False" "High" "IsMasterProtein" "Q96CX6" "Leucine-rich repeat-containing protein 58 OS=Homo sapiens OX=9606 GN=LRRC58 PE=1 SV=2" "0.001" "False" "4.280" "8" "2" "2" "2" "371" "40.6" "6.84" "5.45" "2" "signal transduction" "" "" "Pf00560, Pf12799" "116064" "ENSG00000163428" "LRRC58" "hsa:116064; Q96CX6" "" "" "0" "0" "1.145" "1.121" "1.127" "0.964" "1.127" "1.213" "1.070" "1.167" "1.444" "64.5" "73.9" "72.3" "72.7" "62.2" "72.7" "78.2" "69.0" "75.2" "93.1" "" "" "" "" "" "" "" "" "" "" "58.0" "59.8" "65.4" "70.9" "51.3" "72.7" "58.6" "61.0" "67.3" "33.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2196461866191852716" "False" "High" "IsMasterProtein" "Q9Y5J1" "U3 small nucleolar RNA-associated protein 18 homolog OS=Homo sapiens OX=9606 GN=UTP18 PE=1 SV=3" "0.001" "False" "4.274" "3" "1" "2" "1" "556" "62.0" "8.76" "9.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf00400" "51096" "ENSG00000011260" "UTP18" "hsa:51096; Q9H4N6; Q9Y5J1" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "1.090" "1.098" "0.946" "1.071" "1.142" "1.403" "1.171" "0.844" "0.720" "35.9" "39.2" "39.5" "34.0" "38.5" "41.0" "50.4" "42.1" "30.3" "25.9" "" "" "" "" "" "" "" "" "" "" "32.3" "31.7" "35.7" "33.2" "31.8" "41.0" "37.7" "37.1" "27.1" "9.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4904792924861238037" "False" "High" "IsMasterProtein" "Q9Y5J6" "Mitochondrial import inner membrane translocase subunit Tim10 B OS=Homo sapiens OX=9606 GN=TIMM10B PE=1 SV=1" "0.001" "False" "4.264" "24" "1" "1" "1" "103" "11.6" "7.43" "4.74" "1" "cell adhesion;cell organization and biogenesis;transport" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf02953" "26515" "ENSG00000132286" "TIMM10B" "hsa:26515; Q96FF3; Q9Y5J6" "" "Mitochondrial protein import" "1" "0" "0.768" "1.821" "0.448" "1.024" "0.511" "0.787" "0.439" "0.600" "0.566" "57.6" "44.2" "104.8" "25.8" "59.0" "29.4" "45.3" "25.3" "34.5" "32.6" "" "" "" "" "" "" "" "" "" "" "51.7" "35.8" "94.8" "25.2" "48.6" "29.4" "33.9" "22.3" "30.9" "11.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8933830844704503327" "False" "High" "IsMasterProtein" "Q8N680" "Zinc finger and BTB domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZBTB2 PE=1 SV=1" "0.001" "False" "4.252" "4" "2" "2" "2" "514" "57.3" "6.10" "4.57" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "57621" "ENSG00000181472" "ZBTB2" "A8K7C7; hsa:57621; Q5SZ81; Q8N680; Q9P245" "Ectoderm differentiation" "" "1" "0" "0.897" "1.019" "0.939" "1.034" "0.815" "0.985" "1.005" "0.999" "0.738" "128.9" "115.6" "131.3" "121.0" "133.2" "105.0" "127.0" "129.6" "128.8" "95.2" "" "" "" "" "" "" "" "" "" "" "115.9" "93.6" "118.8" "118.1" "110.0" "105.0" "95.1" "114.4" "115.3" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2618859431670300252" "False" "High" "IsMasterProtein" "Q5VSG8" "Glycoprotein endo-alpha-1,2-mannosidase-like protein OS=Homo sapiens OX=9606 GN=MANEAL PE=1 SV=1" "0.001" "False" "4.247" "2" "1" "1" "1" "457" "51.3" "6.98" "5.29" "1" "" "other membranes;ER/Golgi" "other molecular function" "Pf16317" "149175" "ENSG00000185090" "MANEAL" "hsa:149175; Q5VSG8; Q6DD86; Q6P497; Q8N5P8; Q96G55; Q96N42" "" "" "0" "0" "0.863" "0.783" "0.809" "0.840" "0.871" "0.874" "0.713" "0.653" "0.787" "31.3" "27.0" "24.5" "25.3" "26.3" "27.3" "27.3" "22.3" "20.4" "24.6" "" "" "" "" "" "" "" "" "" "" "28.1" "21.9" "22.2" "24.7" "21.7" "27.3" "20.5" "19.7" "18.3" "8.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2758268738613076417" "False" "High" "IsMasterProtein" "Q9HBM0" "Vezatin OS=Homo sapiens OX=9606 GN=VEZT PE=1 SV=3" "0.001" "False" "4.246" "1" "1" "1" "1" "779" "88.6" "5.20" "3.63" "1" "cell adhesion" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "cytoskeletal activity" "Pf12632" "55591" "ENSG00000028203" "VEZT" "hsa:55591; Q6P1Q3; Q9H2F4; Q9H2U5; Q9HBM0; Q9NT70; Q9NVW0; Q9UF91" "" "" "0" "0" "0.889" "0.852" "0.917" "0.984" "0.990" "1.146" "0.794" "0.843" "0.921" "60.7" "54.0" "51.7" "55.7" "59.8" "60.2" "69.6" "48.2" "51.2" "55.9" "" "" "" "" "" "" "" "" "" "" "54.6" "43.7" "46.8" "54.4" "49.3" "60.2" "52.1" "42.6" "45.8" "20.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4634393773107864734" "False" "High" "IsMasterProtein" "P19474" "E3 ubiquitin-protein ligase TRIM21 OS=Homo sapiens OX=9606 GN=TRIM21 PE=1 SV=1" "0.001" "False" "4.245" "4" "2" "2" "1" "475" "54.1" "6.38" "5.91" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00097, Pf00622, Pf00643, Pf13765" "6737" "ENSG00000132109" "TRIM21" "hsa:6737; P19474; Q5XPV5; Q96RF8" "" "Antigen processing: Ubiquitination & Proteasome degradation; KEAP1-NFE2L2 pathway; Interferon gamma signaling; Regulation of innate immune responses to cytosolic DNA; STING mediated induction of host immune responses" "5" "0" "1.064" "1.284" "1.179" "0.864" "0.983" "1.334" "0.917" "0.948" "3.421" "51.4" "54.7" "66.0" "60.6" "44.4" "50.5" "68.6" "47.2" "48.8" "175.9" "" "" "" "" "" "" "" "" "" "" "46.2" "44.2" "59.7" "59.2" "36.6" "50.5" "51.4" "41.6" "43.6" "62.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6343955122227256194" "False" "High" "IsMasterProtein" "Q01831" "DNA repair protein complementing XP-C cells OS=Homo sapiens OX=9606 GN=XPC PE=1 SV=4" "0.001" "False" "4.245" "2" "1" "1" "1" "940" "105.9" "8.90" "4.87" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03835, Pf10403, Pf10404, Pf10405" "7508" "ENSG00000154767" "XPC" "B4DIP3; E9PB96; E9PH69; hsa:7508; Q01831; Q53GT7; Q96AX0" "Male infertility; Nucleotide excision repair; DNA repair pathways, full network; p53 transcriptional gene network; Nucleotide excision repair in xeroderma pigmentosum" "SUMOylation of DNA damage response and repair proteins; Formation of Incision Complex in GG-NER; DNA Damage Recognition in GG-NER" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8023597143087882212" "False" "High" "IsMasterProtein" "P61925" "cAMP-dependent protein kinase inhibitor alpha OS=Homo sapiens OX=9606 GN=PKIA PE=1 SV=2" "0.001" "False" "4.245" "20" "1" "2" "1" "76" "8.0" "4.54" "9.04" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02827" "5569" "ENSG00000171033" "PKIA" "hsa:5569; P04541; P61925; Q6IAV2" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "" "2" "0" "1.035" "1.087" "1.047" "1.068" "1.299" "0.977" "1.099" "1.095" "1.045" "119.8" "124.0" "130.2" "125.5" "128.0" "155.6" "117.1" "131.7" "131.3" "125.2" "" "" "" "" "" "" "" "" "" "" "107.7" "100.3" "117.8" "122.5" "105.6" "155.6" "87.7" "116.3" "117.4" "44.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6622895814543661851" "False" "High" "IsMasterProtein" "O15504" "Nucleoporin NUP42 OS=Homo sapiens OX=9606 GN=NUP42 PE=1 SV=1" "0.001" "False" "4.237" "4" "2" "2" "2" "423" "44.8" "9.19" "3.27" "2" "transport" "other membranes;cytosol;nucleus" "other molecular function" "Pf18044" "11097" "ENSG00000136243" "NUP42" "A4D143; B4DP42; hsa:11097; O15504; Q49AE7; Q9BS49" "" "HCMV Late Events; HCMV Early Events; ISG15 antiviral mechanism; Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript; Rev-mediated nuclear export of HIV RNA; Transport of Ribonucleoproteins into the Host Nucleus; NS1 Mediated Effects on Host Pathways; Viral Messenger RNA Synthesis; NEP/NS2 Interacts with the Cellular Export Machinery; Regulation of Glucokinase by Glucokinase Regulatory Protein; Nuclear import of Rev protein; Vpr-mediated nuclear import of PICs; snRNP Assembly; SUMOylation of DNA damage response and repair proteins; SUMOylation of ubiquitinylation proteins; Nuclear Pore Complex (NPC) Disassembly; Regulation of HSF1-mediated heat shock response; SUMOylation of SUMOylation proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of DNA replication proteins; Transcriptional regulation by small RNAs; Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC); tRNA processing in the nucleus; SARS-CoV-2 activates/modulates innate and adaptive immune responses" "28" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8569145288368118726" "False" "High" "IsMasterProtein" "Q9NZE8" "Large ribosomal subunit protein bL35m OS=Homo sapiens OX=9606 GN=MRPL35 PE=1 SV=3" "0.001" "False" "4.236" "8" "2" "2" "2" "188" "21.5" "11.30" "6.33" "2" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf01632" "51318" "ENSG00000132313" "MRPL35" "A6NKV6; B2RB93; hsa:51318; Q658U7; Q8WWA2; Q9NZE8" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "1.180" "1.006" "0.978" "1.190" "1.079" "1.155" "1.028" "1.137" "0.949" "91.0" "107.4" "91.6" "89.0" "108.3" "98.2" "105.1" "93.6" "103.5" "86.3" "" "" "" "" "" "" "" "" "" "" "81.8" "86.9" "82.8" "86.9" "89.4" "98.2" "78.7" "82.6" "92.6" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289756953830423632" "False" "High" "IsMasterProtein" "Q8WV99" "AN1-type zinc finger protein 2B OS=Homo sapiens OX=9606 GN=ZFAND2B PE=1 SV=1" "0.001" "False" "4.233" "7" "1" "2" "1" "257" "28.0" "6.92" "6.03" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01428, Pf02809" "130617" "ENSG00000158552" "ZFAND2B" "hsa:130617; Q8NB98; Q8WV99" "" "" "0" "0" "0.917" "0.938" "0.873" "0.822" "1.209" "0.917" "0.851" "0.770" "0.889" "290.9" "266.8" "272.8" "254.1" "239.1" "351.8" "266.7" "247.7" "223.9" "258.7" "" "" "" "" "" "" "" "" "" "" "261.6" "215.9" "246.7" "248.1" "197.4" "351.8" "199.7" "218.7" "200.4" "92.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9220853686183247090" "False" "High" "IsMasterProtein" "Cont_P01966" "Hemoglobin subunit alpha OS=Bos taurus OX=9913 GN=HBA PE=1 SV=2" "0.001" "True" "4.223" "11" "1" "1" "1" "142" "15.2" "8.44" "4.48" "1" "other metabolic processes;transport;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00042" "100140149; 109578761; 512439" "ENSBIXG00000028763; ENSBIXG00005026352; ENSBTAG00000051412" "GLNC1; HBA; LOC109578761; LOC113883300" "A0A1K0FUD3; A0A4W2IFB1; A0A6P5DZW6; A3KN13; biu:109578761; bta:100140149; bta:512439; P01966; Q3SZE0; Q9TTR9; Q9TTS0; Q9TTS1" "" "Cytoprotection by HMOX1; Scavenging of heme from plasma; Erythrocytes take up carbon dioxide and release oxygen; Heme signaling; Erythrocytes take up oxygen and release carbon dioxide" "5" "0" "0.964" "1.033" "0.636" "0.874" "0.862" "0.778" "0.767" "0.761" "0.934" "61.5" "59.3" "63.5" "39.1" "53.7" "53.0" "47.8" "47.2" "46.8" "57.4" "" "" "" "" "" "" "" "" "" "" "55.3" "48.0" "57.4" "38.2" "44.3" "53.0" "35.8" "41.7" "41.9" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2036393970743301611" "False" "High" "IsMasterProtein" "Q8N9M5" "Transmembrane protein 102 OS=Homo sapiens OX=9606 GN=TMEM102 PE=1 SV=1" "0.001" "False" "4.214" "2" "1" "1" "1" "508" "54.1" "5.91" "3.76" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;other cell component" "" "" "284114" "ENSG00000181284; ENSG00000284228" "TMEM102" "D3DTP8; hsa:284114; Q8N9M5" "" "" "0" "0" "1.095" "0.935" "0.852" "1.173" "1.044" "1.154" "0.986" "0.839" "1.173" "166.9" "182.8" "156.0" "142.1" "195.8" "174.3" "192.5" "164.6" "140.1" "195.8" "" "" "" "" "" "" "" "" "" "" "150.0" "147.9" "141.2" "138.7" "161.6" "174.3" "144.2" "145.4" "125.3" "69.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8796494358208286293" "False" "High" "IsMasterProtein" "P21854" "B-cell differentiation antigen CD72 OS=Homo sapiens OX=9606 GN=CD72 PE=1 SV=1" "0.001" "False" "4.212" "4" "1" "1" "1" "359" "40.2" "8.28" "3.17" "1" "cell adhesion" "plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf00059" "971" "ENSG00000137101" "CD72" "hsa:971; P21854" "" "Other semaphorin interactions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2363903174010187196" "False" "High" "IsMasterProtein" "Q6W2J9" "BCL-6 corepressor OS=Homo sapiens OX=9606 GN=BCOR PE=1 SV=1" "0.001" "False" "4.211" "1" "1" "1" "1" "1755" "192.1" "6.48" "4.86" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796, Pf15808, Pf16553" "54880" "ENSG00000183337" "BCOR" "D3DWB3; D3DWB4; hsa:54880; Q29RF6; Q6P4B6; Q6W2J9; Q7Z2K7; Q8TEB4; Q96DB3; Q9H232; Q9H233; Q9HCJ7; Q9NXF2" "Ectoderm differentiation; Pathways affected in adenoid cystic carcinoma; FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma" "" "3" "0" "0.925" "1.025" "0.896" "0.682" "0.847" "1.059" "0.627" "1.019" "1.289" "26.8" "24.8" "27.5" "24.0" "18.3" "22.7" "28.4" "16.8" "27.3" "34.5" "" "" "" "" "" "" "" "" "" "" "24.1" "20.1" "24.9" "23.4" "15.1" "22.7" "21.3" "14.8" "24.4" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6613214644260606221" "False" "High" "IsMasterProtein" "Q9NUN5" "Lysosomal cobalamin transport escort protein LMBD1 OS=Homo sapiens OX=9606 GN=LMBRD1 PE=1 SV=1" "0.001" "False" "4.203" "3" "1" "1" "1" "540" "61.3" "7.77" "3.42" "1" "transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;transporter activity;other molecular function" "Pf04791" "55788" "ENSG00000168216" "LMBRD1" "A8K204; E1P531; hsa:55788; Q5VUN6; Q86Y70; Q96FW4; Q9BY56; Q9NUN5; Q9NZD6" "" "Defective ABCD4 causes MAHCJ; Uptake of dietary cobalamins into enterocytes; Transport of RCbl within the body" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8998868825977106546" "False" "High" "IsMasterProtein" "Q9H3Z4" "DnaJ homolog subfamily C member 5 OS=Homo sapiens OX=9606 GN=DNAJC5 PE=1 SV=1" "0.001" "False" "4.201" "5" "1" "1" "1" "198" "22.1" "5.07" "3.91" "1" "cell-cell signaling;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00226" "80331" "ENSG00000101152" "DNAJC5" "A8K0M0; B3KY68; E1P5G8; hsa:80331; Q9H3Z4; Q9H3Z5; Q9H7H2" "" "Neutrophil degranulation; Sensory processing of sound by inner hair cells of the cochlea; GABA synthesis, release, reuptake and degradation" "3" "0" "0.891" "0.931" "1.071" "0.712" "0.780" "1.108" "1.103" "0.902" "0.943" "89.3" "79.6" "83.1" "95.7" "63.6" "69.6" "98.9" "98.5" "80.5" "84.2" "" "" "" "" "" "" "" "" "" "" "80.3" "64.4" "75.2" "93.4" "52.5" "69.6" "74.1" "87.0" "72.1" "30.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7167041566668473319" "False" "High" "IsMasterProtein" "Q96RK0" "Protein capicua homolog OS=Homo sapiens OX=9606 GN=CIC PE=1 SV=3" "0.001" "False" "4.200" "1" "1" "1" "1" "2517" "257.9" "8.10" "4.59" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00505, Pf16090" "23152" "ENSG00000079432" "CIC" "A0A7P0T9K5" "" "" "0" "0" "1.211" "1.093" "1.082" "1.162" "1.185" "1.402" "1.368" "1.075" "1.197" "31.8" "38.5" "34.7" "34.4" "36.9" "37.7" "44.6" "43.5" "34.2" "38.1" "" "" "" "" "" "" "" "" "" "" "28.6" "31.1" "31.4" "33.6" "30.5" "37.7" "33.4" "38.4" "30.6" "13.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "62190601314665841" "False" "High" "IsMasterProtein" "Q14207" "Protein NPAT OS=Homo sapiens OX=9606 GN=NPAT PE=1 SV=3" "0.001" "False" "4.197" "1" "1" "1" "1" "1427" "154.2" "5.88" "3.94" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15712" "4863" "ENSG00000149308" "NPAT" "A8K1V5; A8K6M2; hsa:4863; Q13632; Q14207; Q14967; Q16580; Q86W55; Q8IWE9" "Retinoblastoma gene in cancer" "" "1" "0" "0.972" "1.196" "1.419" "0.908" "1.128" "1.008" "1.080" "1.111" "1.562" "91.0" "88.4" "108.9" "129.1" "82.7" "102.6" "91.7" "98.3" "101.1" "142.2" "" "" "" "" "" "" "" "" "" "" "81.8" "71.6" "98.5" "126.0" "68.2" "102.6" "68.7" "86.8" "90.5" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6827069170954705052" "False" "High" "IsMasterProtein" "Q9UKJ3" "G patch domain-containing protein 8 OS=Homo sapiens OX=9606 GN=GPATCH8 PE=1 SV=2" "0.001" "False" "4.192" "1" "2" "2" "2" "1502" "164.1" "8.66" "5.83" "2" "" "nucleus" "other molecular function" "Pf01585" "23131" "ENSG00000186566" "GPATCH8" "B9EGP9; hsa:23131; O60300; Q8TB99; Q9UKJ3" "" "" "0" "0" "1.069" "1.222" "0.997" "1.022" "1.338" "1.188" "1.164" "1.051" "1.289" "41.2" "44.1" "50.4" "41.1" "42.2" "55.2" "49.0" "48.0" "43.4" "53.2" "" "" "" "" "" "" "" "" "" "" "37.1" "35.7" "45.6" "40.2" "34.8" "55.2" "36.7" "42.4" "38.8" "19.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1017174203569406372" "False" "High" "IsMasterProtein" "Q86UW6" "NEDD4-binding protein 2 OS=Homo sapiens OX=9606 GN=N4BP2 PE=1 SV=2" "0.001" "False" "4.188" "1" "2" "2" "1" "1770" "198.7" "5.21" "4.48" "2" "DNA metabolism" "cytosol" "kinase activity;other molecular function" "Pf01713, Pf08590, Pf13671" "55728" "ENSG00000078177" "N4BP2" "A0AVR3; hsa:55728; Q86UW6; Q9NVK2; Q9P2D4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6009114136998479207" "False" "High" "IsMasterProtein" "Q9GZR1" "Sentrin-specific protease 6 OS=Homo sapiens OX=9606 GN=SENP6 PE=1 SV=2" "0.001" "False" "4.181" "1" "1" "1" "1" "1112" "126.1" "6.73" "3.59" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02902" "26054" "ENSG00000112701" "SENP6" "A6NNY9; hsa:26054; O94891; Q5VUL3; Q5VUL4; Q8TBY4; Q9GZR1; Q9UJV5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3441186793177341923" "False" "High" "IsMasterProtein" "Q969M3" "Protein YIPF5 OS=Homo sapiens OX=9606 GN=YIPF5 PE=1 SV=1" "0.001" "False" "4.175" "5" "1" "1" "1" "257" "28.0" "4.36" "4.04" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "" "Pf04893" "81555" "ENSG00000145817" "YIPF5" "D3DQF5; hsa:81555; Q4VSN6; Q53EX4; Q8NHE5; Q969M3; Q9H338; Q9H3U4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1681159057880383984" "False" "High" "IsMasterProtein" "Q00537" "Cyclin-dependent kinase 17 OS=Homo sapiens OX=9606 GN=CDK17 PE=1 SV=2" "0.001" "False" "4.167" "3" "2" "4" "1" "523" "59.5" "9.03" "11.63" "2" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "5128" "ENSG00000059758" "CDK17" "A8K1U6; B2RCQ2; hsa:5128; Q00537; Q8NEB8" "" "" "0" "0" "1.134" "0.793" "0.688" "1.286" "1.228" "1.306" "1.172" "1.052" "0.925" "265.3" "301.0" "210.4" "182.6" "341.2" "325.8" "346.4" "310.9" "279.0" "245.5" "" "" "" "" "" "" "" "" "" "" "238.5" "243.5" "190.3" "178.2" "281.6" "325.8" "259.4" "274.6" "249.6" "87.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5183931904293870446" "False" "High" "IsMasterProtein" "Q96FX2" "Diphthamide biosynthesis protein 3 OS=Homo sapiens OX=9606 GN=DPH3 PE=1 SV=1" "0.001" "False" "4.163" "20" "1" "2" "1" "82" "9.2" "4.09" "8.99" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf05207" "285381" "ENSG00000154813" "DPH3" "hsa:285381; Q96FX2" "" "Synthesis of diphthamide-EEF2" "1" "0" "1.009" "0.907" "0.961" "0.981" "1.110" "0.882" "1.074" "0.930" "0.882" "111.5" "112.5" "101.1" "107.2" "109.4" "123.7" "98.3" "119.8" "103.7" "98.4" "" "" "" "" "" "" "" "" "" "" "100.3" "91.0" "91.5" "104.6" "90.3" "123.7" "73.6" "105.8" "92.8" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4453552053953244697" "False" "High" "IsMasterProtein" "P19634" "Sodium/hydrogen exchanger 1 OS=Homo sapiens OX=9606 GN=SLC9A1 PE=1 SV=2" "0.001" "False" "4.163" "3" "1" "1" "1" "815" "90.7" "7.21" "3.93" "1" "cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf00999, Pf16644" "6548" "ENSG00000090020" "SLC9A1" "B1ALD6; D3DPL4; hsa:6548; P19634; Q96EM2" "Osteoclast signaling; G protein signaling pathways; Gastrin signaling pathway; Opioid receptor pathways; Regulation of actin cytoskeleton" "Hyaluronan uptake and degradation; Sodium/Proton exchangers" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-3192969394575095847" "False" "High" "IsMasterProtein" "Q9BT17" "Mitochondrial ribosome-associated GTPase 1 OS=Homo sapiens OX=9606 GN=MTG1 PE=1 SV=2" "0.001" "False" "4.160" "5" "2" "2" "2" "334" "37.2" "9.47" "5.37" "2" "protein metabolism;other metabolic processes;other biological processes" "other membranes;mitochondrion;translational apparatus;nucleus" "other molecular function" "Pf01926" "92170" "ENSG00000148824" "MTG1" "hsa:92170; Q5VWX8; Q6PIY9; Q8IYJ4; Q8NC48; Q9BT17; Q9BVU8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8545546198445454404" "False" "High" "IsMasterProtein" "E5RHQ5" "Nuclear pore complex-interacting protein family member B11 OS=Homo sapiens OX=9606 GN=NPIPB11 PE=3 SV=1" "0.001" "False" "4.159" "3" "2" "2" "2" "1161" "129.1" "10.04" "4.97" "2" "" "other membranes" "" "Pf06409, Pf20885" "" "ENSG00000254206" "NPIPB11" "E5RHQ5" "" "" "0" "0" "0.925" "0.984" "0.901" "0.945" "0.943" "0.870" "0.896" "1.073" "0.643" "238.0" "220.0" "234.0" "214.5" "225.0" "224.5" "207.1" "213.3" "255.2" "153.0" "" "" "" "" "" "" "" "" "" "" "213.9" "178.0" "211.7" "209.3" "185.6" "224.5" "155.0" "188.4" "228.4" "54.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9153157307515931541" "False" "High" "IsMasterProtein" "Q9UBI9" "Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1" "0.001" "False" "4.156" "3" "2" "2" "2" "543" "58.8" "8.54" "2.98" "2" "developmental processes;other biological processes" "nucleus;other cell component" "" "Pf15353, Pf16002" "51696" "ENSG00000112406" "HECA" "hsa:51696; Q9UBI9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7043432361938153889" "False" "High" "IsMasterProtein" "Q8NCP5" "Zinc finger and BTB domain-containing protein 44 OS=Homo sapiens OX=9606 GN=ZBTB44 PE=1 SV=1" "0.001" "False" "4.154" "2" "1" "1" "1" "570" "63.8" "6.61" "4.54" "1" "" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "29068" "ENSG00000196323" "ZBTB44" "hsa:29068; Q6IPT8; Q86VJ7; Q86XX5; Q8NCP5" "" "" "0" "0" "0.820" "0.923" "0.977" "0.930" "1.029" "1.057" "1.025" "1.353" "0.907" "115.7" "94.9" "106.8" "113.1" "107.6" "119.1" "122.3" "118.6" "156.5" "104.9" "" "" "" "" "" "" "" "" "" "" "104.0" "76.8" "96.6" "110.4" "88.8" "119.1" "91.6" "104.8" "140.0" "37.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2322848186288192212" "False" "High" "IsMasterProtein" "Q6UWS5" "Protein PET117 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=PET117 PE=1 SV=1" "0.001" "False" "4.153" "20" "1" "1" "1" "81" "9.2" "10.10" "5.16" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf15786" "100303755" "ENSG00000232838" "PET117" "hsa:100303755; Q6UWS5" "Mitochondrial complex IV assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4298882931648225908" "False" "High" "IsMasterProtein" "Q9UGJ1" "Gamma-tubulin complex component 4 OS=Homo sapiens OX=9606 GN=TUBGCP4 PE=1 SV=1" "0.001" "False" "4.144" "3" "2" "2" "2" "667" "76.0" "6.65" "2.74" "2" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;other cytoplasmic organelle" "cytoskeletal activity" "Pf04130, Pf17681" "27229" "ENSG00000137822" "TUBGCP4" "B3KNK6; hsa:27229; Q969X3; Q9NVF0; Q9UGJ1" "Prader-Willi and Angelman syndrome; 15q11.2 copy number variation syndrome" "Recruitment of NuMA to mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes" "4" "0" "1.023" "1.110" "1.007" "1.052" "0.934" "1.107" "1.012" "0.951" "1.347" "330.0" "337.5" "366.3" "332.2" "347.2" "308.1" "365.2" "333.9" "313.8" "444.4" "" "" "" "" "" "" "" "" "" "" "296.7" "273.1" "331.3" "324.3" "286.5" "308.1" "273.4" "294.9" "280.8" "158.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1490938523091261989" "False" "High" "IsMasterProtein" "O60292" "Signal-induced proliferation-associated 1-like protein 3 OS=Homo sapiens OX=9606 GN=SIPA1L3 PE=1 SV=3" "0.001" "False" "4.143" "1" "1" "1" "1" "1781" "194.5" "8.32" "3.54" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "23094" "ENSG00000105738" "SIPA1L3" "hsa:23094; O60292; Q2TV87" "" "" "0" "0" "0.970" "0.695" "1.053" "1.243" "0.708" "1.417" "1.008" "1.013" "1.339" "12.2" "11.9" "8.5" "12.9" "15.2" "8.7" "17.4" "12.4" "12.4" "16.4" "" "" "" "" "" "" "" "" "" "" "11.0" "9.6" "7.7" "12.6" "12.6" "8.7" "13.0" "10.9" "11.1" "5.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4406429710445880592" "False" "High" "IsMasterProtein" "Q14511" "Enhancer of filamentation 1 OS=Homo sapiens OX=9606 GN=NEDD9 PE=1 SV=1" "0.001" "False" "4.134" "3" "2" "2" "2" "834" "92.8" "6.70" "3.83" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf08824, Pf12026, Pf14604" "4739" "ENSG00000111859" "NEDD9" "A8K9G7; A8MSJ9; G5E9Y9; hsa:4739; Q14511; Q5T9R4; Q5XKI0" "TGF-beta signaling pathway; HDAC6 interactions in the central nervous system" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1617680117434618445" "False" "High" "IsMasterProtein" "P42696" "RNA-binding protein 34 OS=Homo sapiens OX=9606 GN=RBM34 PE=1 SV=2" "0.001" "False" "4.128" "3" "1" "1" "1" "430" "48.5" "10.11" "4.61" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "23029" "ENSG00000188739" "RBM34" "A8K8J7; hsa:23029; P42696; Q8N2Z8; Q9H5A1" "" "" "0" "0" "0.824" "0.648" "0.858" "1.006" "0.700" "0.852" "0.932" "0.494" "0.593" "46.2" "38.1" "29.9" "39.7" "46.5" "32.3" "39.4" "43.1" "22.8" "27.4" "" "" "" "" "" "" "" "" "" "" "41.6" "30.8" "27.1" "38.7" "38.4" "32.3" "29.5" "38.1" "20.4" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2743146227967072639" "False" "High" "IsMasterProtein" "Q86WP2" "Vasculin OS=Homo sapiens OX=9606 GN=GPBP1 PE=1 SV=1" "0.001" "False" "4.124" "3" "1" "1" "1" "473" "53.3" "7.05" "4.35" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15337" "65056" "ENSG00000062194" "GPBP1" "A6NKW3; hsa:65056; Q6NSH6; Q86WP2; Q9H0D4; Q9H785; Q9NSN4" "" "" "0" "0" "1.064" "1.137" "0.796" "0.979" "1.181" "0.759" "1.076" "1.169" "1.152" "23.8" "25.3" "27.0" "18.9" "23.3" "28.0" "18.0" "25.6" "27.8" "27.4" "" "" "" "" "" "" "" "" "" "" "21.4" "20.5" "24.4" "18.5" "19.2" "28.0" "13.5" "22.6" "24.9" "9.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7485142427568366731" "False" "High" "IsMasterProtein" "Q15543" "Transcription initiation factor TFIID subunit 13 OS=Homo sapiens OX=9606 GN=TAF13 PE=1 SV=1" "0.001" "False" "4.120" "9" "1" "1" "1" "124" "14.3" "4.81" "4.59" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf02269" "6884" "ENSG00000197780" "TAF13" "B2R5E5; hsa:6884; Q15543; Q5TYV6" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "1.120" "1.006" "0.998" "1.135" "1.055" "1.270" "1.125" "1.084" "0.994" "106.5" "119.3" "107.2" "106.3" "121.0" "112.4" "135.3" "119.8" "115.5" "105.9" "" "" "" "" "" "" "" "" "" "" "95.8" "96.5" "96.9" "103.8" "99.8" "112.4" "101.3" "105.8" "103.3" "37.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8213215215106064220" "False" "High" "IsMasterProtein" "Q8WZ82" "Esterase OVCA2 OS=Homo sapiens OX=9606 GN=OVCA2 PE=1 SV=1" "0.001" "False" "4.113" "6" "1" "1" "1" "227" "24.4" "6.89" "4.48" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf03959" "124641" "ENSG00000262664" "OVCA2" "hsa:124641; Q86XN3; Q8IW87; Q8WZ82; Q9UCX9" "" "" "0" "0" "1.097" "0.933" "1.029" "1.165" "1.116" "1.199" "1.046" "0.931" "1.700" "47.2" "51.8" "44.0" "48.6" "55.0" "52.7" "56.6" "49.4" "44.0" "80.2" "" "" "" "" "" "" "" "" "" "" "42.4" "41.9" "39.8" "47.4" "45.4" "52.7" "42.4" "43.6" "39.3" "28.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8343966935655594345" "False" "High" "IsMasterProtein" "P56385" "ATP synthase subunit e, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5ME PE=1 SV=2" "0.001" "False" "4.108" "14" "1" "1" "1" "69" "7.9" "9.35" "4.71" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05680" "521" "ENSG00000169020" "ATP5ME" "hsa:521; P56385; Q0D2L9" "Electron transport chain: OXPHOS system in mitochondria; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "4" "0" "0.984" "1.210" "1.002" "1.057" "1.275" "0.976" "1.083" "1.301" "0.972" "172.6" "169.8" "208.8" "172.9" "182.4" "220.0" "168.5" "186.9" "224.6" "167.7" "" "" "" "" "" "" "" "" "" "" "155.1" "137.4" "188.9" "168.8" "150.5" "220.0" "126.1" "165.1" "200.9" "59.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5030873736405490960" "False" "High" "IsMasterProtein" "Q92686" "Neurogranin OS=Homo sapiens OX=9606 GN=NRGN PE=1 SV=1" "0.001" "False" "4.107" "18" "1" "2" "1" "78" "7.6" "7.87" "9.53" "1" "developmental processes;signal transduction" "cytosol" "other molecular function" "Pf00612" "4900" "ENSG00000154146" "NRGN" "hsa:4900; Q92686" "" "Long-term potentiation" "1" "0" "0.968" "1.012" "0.850" "0.968" "0.953" "0.885" "0.986" "0.982" "0.687" "169.1" "163.7" "171.2" "143.7" "163.7" "161.2" "149.7" "166.7" "166.0" "116.2" "" "" "" "" "" "" "" "" "" "" "152.0" "132.5" "154.9" "140.3" "135.1" "161.2" "112.1" "147.2" "148.5" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "713100355738171482" "False" "High" "IsMasterProtein" "Q8N302" "Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens OX=9606 GN=AGGF1 PE=1 SV=2" "0.002" "False" "4.105" "2" "1" "1" "1" "714" "80.9" "5.44" "4.45" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;other cell component" "nucleic acid binding activity" "Pf00498, Pf01585, Pf17780" "55109" "ENSG00000164252" "AGGF1" "hsa:55109; O00581; Q53YS3; Q8N302; Q9BU84; Q9NW66" "" "Signaling by BRAF and RAF1 fusions" "1" "0" "0.854" "0.807" "0.867" "0.944" "0.941" "1.038" "0.926" "0.831" "0.998" "94.3" "80.5" "76.2" "81.8" "89.1" "88.8" "97.9" "87.4" "78.4" "94.1" "" "" "" "" "" "" "" "" "" "" "84.8" "65.2" "68.9" "79.8" "73.5" "88.8" "73.3" "77.2" "70.1" "33.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-150019997035989311" "False" "High" "IsMasterProtein" "Q96JK2" "DDB1- and CUL4-associated factor 5 OS=Homo sapiens OX=9606 GN=DCAF5 PE=1 SV=2" "0.002" "False" "4.105" "1" "1" "1" "1" "942" "103.9" "5.76" "3.27" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "" "Pf00400" "8816" "ENSG00000139990" "DCAF5" "B2RN31; G3V4J7; hsa:8816; O60559; Q8N3V3; Q8N3V5; Q96JK2" "" "Neddylation" "1" "0" "1.132" "1.148" "0.824" "1.299" "1.080" "1.049" "0.970" "1.198" "2.645" "35.2" "39.9" "40.4" "29.0" "45.8" "38.0" "36.9" "34.1" "42.2" "93.2" "" "" "" "" "" "" "" "" "" "" "31.7" "32.3" "36.6" "28.3" "37.8" "38.0" "27.7" "30.2" "37.8" "33.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5042642415102067907" "False" "High" "IsMasterProtein" "Q99549" "M-phase phosphoprotein 8 OS=Homo sapiens OX=9606 GN=MPHOSPH8 PE=1 SV=2" "0.002" "False" "4.105" "3" "2" "2" "2" "860" "97.1" "6.06" "5.73" "2" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00385, Pf12796" "54737" "ENSG00000196199" "MPHOSPH8" "B7Z6F9; hsa:54737; Q5JPE5; Q5JTQ0; Q86TK3; Q96MK4; Q99549; Q9BTP1" "" "" "0" "0" "1.010" "0.962" "0.807" "0.968" "1.286" "0.980" "0.879" "0.942" "1.067" "95.8" "96.9" "92.2" "77.3" "92.8" "123.3" "93.9" "84.3" "90.3" "102.2" "" "" "" "" "" "" "" "" "" "" "86.2" "78.4" "83.4" "75.5" "76.6" "123.3" "70.3" "74.4" "80.8" "36.5" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728646887416176304" "False" "High" "IsMasterProtein" "Q8IYL3" "UPF0688 protein C1orf174 OS=Homo sapiens OX=9606 GN=C1orf174 PE=1 SV=2" "0.002" "False" "4.099" "7" "1" "1" "1" "243" "26.0" "6.90" "2.88" "1" "" "nucleus" "" "Pf15772" "339448" "ENSG00000198912" "C1orf174" "A8K0C8; A8MUG9; hsa:339448; Q5SR20; Q6NX36; Q8IYL3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-8114492968310580525" "False" "High" "IsMasterProtein" "P98194" "Calcium-transporting ATPase type 2C member 1 OS=Homo sapiens OX=9606 GN=ATP2C1 PE=1 SV=3" "0.002" "False" "4.095" "1" "1" "1" "1" "919" "100.5" "6.74" "3.33" "1" "cell adhesion;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00122, Pf00689, Pf00690, Pf13246" "27032" "ENSG00000017260" "ATP2C1" "B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9; hsa:27032; O76005; P98194; Q86V72; Q86V73; Q8N6V1; Q8NCJ7" "" "Ion transport by P-type ATPases" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8813199514956100081" "False" "High" "IsMasterProtein" "O94822" "E3 ubiquitin-protein ligase listerin OS=Homo sapiens OX=9606 GN=LTN1 PE=1 SV=6" "0.002" "False" "4.092" "1" "2" "2" "2" "1766" "200.4" "6.25" "4.73" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "translation activity;other molecular function" "" "26046" "ENSG00000198862; ENSG00000291534" "LTN1" "A6NL41; A7E2D0; B2RTS0; C9J7U3; J3KPL4; O94822; Q05C47; Q9H8M4; Q9NUY5; Q9P0E9" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.925" "0.799" "0.802" "0.818" "0.776" "0.828" "0.759" "0.863" "1.356" "100.6" "93.1" "80.4" "80.6" "82.3" "78.0" "83.3" "76.3" "86.8" "136.4" "" "" "" "" "" "" "" "" "" "" "90.5" "75.3" "72.7" "78.7" "67.9" "78.0" "62.4" "67.4" "77.7" "48.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7740288424381142174" "False" "High" "IsMasterProtein" "O43181" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS4 PE=1 SV=1" "0.002" "False" "4.092" "9" "1" "2" "1" "175" "20.1" "10.30" "10.25" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04800" "4724" "ENSG00000164258" "NDUFS4" "hsa:4724; O43181; Q9BS69" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6085162609898003873" "False" "High" "IsMasterProtein" "Q9Y6M5" "Proton-coupled zinc antiporter SLC30A1 OS=Homo sapiens OX=9606 GN=SLC30A1 PE=1 SV=3" "0.002" "False" "4.090" "2" "1" "1" "1" "507" "55.3" "6.48" "3.34" "1" "stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01545" "7779" "ENSG00000170385" "SLC30A1" "hsa:7779; Q0VAK9; Q9BZF6; Q9Y6M5" "Zinc homeostasis" "Zinc efflux and compartmentalization by the SLC30 family" "2" "0" "1.089" "1.074" "0.814" "1.286" "1.449" "1.146" "0.905" "1.364" "1.083" "65.7" "71.5" "70.6" "53.5" "84.5" "95.2" "75.3" "59.4" "89.6" "71.1" "" "" "" "" "" "" "" "" "" "" "59.1" "57.9" "63.9" "52.2" "69.7" "95.2" "56.4" "52.5" "80.2" "25.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3742199827484990276" "False" "High" "IsMasterProtein" "P53667" "LIM domain kinase 1 OS=Homo sapiens OX=9606 GN=LIMK1 PE=1 SV=3" "0.002" "False" "4.087" "2" "1" "1" "1" "647" "72.5" "6.98" "4.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3984" "ENSG00000106683" "LIMK1" "B7Z6I8; D3DXF4; D3DXF5; hsa:3984; O15283; P53667; Q15820; Q15821; Q75MU3; Q9Y5Q1" "Microtubule cytoskeleton regulation; VEGFA-VEGFR2 signaling; 7q11.23 copy number variation syndrome; CCL18 signaling pathway; Regulation of actin cytoskeleton; G13 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; EPHB-mediated forward signaling; Sema3A PAK dependent Axon repulsion; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs; RHO GTPases activate PAKs" "12" "0" "0.961" "1.095" "1.353" "0.922" "1.132" "1.044" "0.930" "0.960" "3.444" "76.2" "73.3" "83.5" "103.2" "70.3" "86.3" "79.6" "70.9" "73.2" "262.6" "" "" "" "" "" "" "" "" "" "" "68.5" "59.3" "75.5" "100.7" "58.0" "86.3" "59.6" "62.6" "65.5" "93.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2812564218304631981" "False" "High" "IsMasterProtein" "Q9NRD1" "F-box only protein 6 OS=Homo sapiens OX=9606 GN=FBXO6 PE=1 SV=1" "0.002" "False" "4.086" "4" "1" "1" "1" "293" "33.9" "6.09" "3.97" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction" "cytosol;ER/Golgi;other cell component" "other molecular function" "Pf04300, Pf12937" "26270" "ENSG00000116663" "FBXO6" "B1AK42; B2RC88; hsa:26270; Q9NRD1; Q9UKT3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3783621162172782203" "False" "High" "IsMasterProtein" "P61225" "Ras-related protein Rap-2b OS=Homo sapiens OX=9606 GN=RAP2B PE=1 SV=1" "0.002" "False" "4.081" "13" "2" "2" "2" "183" "20.5" "4.81" "3.54" "2" "cell adhesion;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "5912" "ENSG00000181467" "RAP2B" "hsa:5912; P17964; P61225; Q96EG5; Q9CXG0" "" "Neutrophil degranulation" "1" "0" "1.016" "0.916" "1.042" "0.952" "1.103" "1.139" "0.947" "0.939" "1.130" "57.7" "58.6" "52.8" "60.1" "54.9" "63.6" "65.7" "54.6" "54.2" "65.2" "" "" "" "" "" "" "" "" "" "" "51.9" "47.4" "47.8" "58.7" "45.3" "63.6" "49.2" "48.2" "48.5" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "338471368414013319" "False" "High" "IsMasterProtein" "Q96T60" "Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens OX=9606 GN=PNKP PE=1 SV=1" "0.002" "False" "4.076" "2" "1" "1" "1" "521" "57.0" "8.46" "4.11" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf08645, Pf13671, Pf17913" "11284" "ENSG00000039650" "PNKP" "hsa:11284; Q96T60; Q9BUL2; Q9P1V2; Q9UKU8; Q9UNF8; Q9UNI0" "Base excision repair; DNA repair pathways, full network" "APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway" "3" "0" "1.291" "1.408" "1.017" "1.374" "1.331" "1.208" "1.152" "1.239" "1.794" "90.8" "117.1" "127.8" "92.3" "124.7" "120.8" "109.6" "104.5" "112.5" "162.9" "" "" "" "" "" "" "" "" "" "" "81.6" "94.8" "115.6" "90.1" "102.9" "120.8" "82.1" "92.3" "100.7" "58.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6559218798370917350" "False" "High" "IsMasterProtein" "Q6ZUT9" "DENN domain-containing protein 5B OS=Homo sapiens OX=9606 GN=DENND5B PE=1 SV=2" "0.002" "False" "4.061" "1" "2" "3" "2" "1274" "144.9" "6.73" "4.69" "2" "other biological processes" "other membranes;cytosol" "enzyme regulator activity;other molecular function" "Pf01477, Pf02141, Pf02759, Pf03455, Pf03456" "160518" "ENSG00000170456" "DENND5B" "B5ME75; hsa:160518; Q59FW8; Q68CZ7; Q6NUJ0; Q6ZUT9; Q7Z3F9; Q8N973; Q8WUC8" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3387363909375928401" "False" "High" "IsMasterProtein" "Q0ZGT2" "Nexilin OS=Homo sapiens OX=9606 GN=NEXN PE=1 SV=1" "0.002" "False" "4.052" "2" "1" "1" "1" "675" "80.6" "5.33" "4.02" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf07679" "91624" "ENSG00000162614" "NEXN" "A0PJ84; B4DPZ7; hsa:91624; Q0D2H2; Q0ZGT2; Q14CC2; Q14CC3; Q16081; Q7Z2X0; Q96DL0; Q9Y2V1" "VEGFA-VEGFR2 signaling" "" "1" "0" "0.999" "0.965" "0.927" "1.020" "1.090" "1.046" "1.190" "1.107" "1.067" "72.9" "72.8" "70.3" "67.5" "74.3" "79.4" "76.2" "86.7" "80.7" "77.7" "" "" "" "" "" "" "" "" "" "" "65.5" "58.9" "63.6" "65.9" "61.3" "79.4" "57.0" "76.6" "72.2" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2318951358478494228" "False" "High" "IsMasterProtein" "Q8WW01" "tRNA-splicing endonuclease subunit Sen15 OS=Homo sapiens OX=9606 GN=TSEN15 PE=1 SV=1" "0.002" "False" "4.049" "9" "1" "1" "1" "171" "18.6" "4.58" "2.88" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "Pf09631" "116461" "ENSG00000198860" "TSEN15" "B4DKP0; hsa:116461; Q8WW01; Q9BZQ5" "" "tRNA processing in the nucleus" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7226837977459101745" "False" "High" "IsMasterProtein" "P27701" "CD82 antigen OS=Homo sapiens OX=9606 GN=CD82 PE=1 SV=1" "0.002" "False" "4.046" "4" "1" "1" "1" "267" "29.6" "5.24" "4.31" "1" "" "plasma membrane;other membranes" "" "Pf00335" "3732" "ENSG00000085117" "CD82" "D3DQN6; E9PC70; hsa:3732; P27701; Q7Z2D4; Q7Z5N2" "16p11.2 distal deletion syndrome; Extrafollicular and follicular B cell activation by SARS-CoV-2; 11p11.2 copy number variation syndrome" "" "3" "0" "0.926" "0.914" "1.070" "1.025" "0.829" "0.932" "0.983" "1.111" "0.699" "98.5" "91.2" "90.0" "105.4" "100.9" "81.6" "91.8" "96.8" "109.4" "68.9" "" "" "" "" "" "" "" "" "" "" "88.5" "73.8" "81.4" "102.9" "83.3" "81.6" "68.7" "85.5" "97.9" "24.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1775190888259302728" "False" "High" "IsMasterProtein" "Q6P2C8" "Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens OX=9606 GN=MED27 PE=1 SV=1" "0.002" "False" "4.046" "6" "2" "3" "2" "311" "35.4" "9.31" "4.92" "2" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf11571" "9442" "ENSG00000160563" "MED27" "hsa:9442; O95401; Q4F964; Q5VTA4; Q5VTA5; Q6P2C8; Q9BU57; Q9NYR4; V9GYV9" "" "Generic Transcription Pathway; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "4" "0" "1.066" "0.958" "0.708" "0.931" "0.841" "0.842" "0.743" "0.749" "1.166" "85.7" "91.4" "82.1" "60.7" "79.8" "72.1" "72.2" "63.7" "64.2" "99.9" "" "" "" "" "" "" "" "" "" "" "77.1" "73.9" "74.3" "59.2" "65.8" "72.1" "54.1" "56.2" "57.5" "35.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-582593904784736124" "False" "High" "IsMasterProtein" "Q9Y5W9" "Sorting nexin-11 OS=Homo sapiens OX=9606 GN=SNX11 PE=1 SV=2" "0.002" "False" "4.045" "8" "1" "2" "1" "270" "30.4" "7.05" "7.16" "1" "cell organization and biogenesis;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00787" "29916" "ENSG00000002919" "SNX11" "B3KRL6; B4DPY5; D3DTV0; hsa:29916; Q53YC0; Q9H885; Q9Y5W9" "" "" "0" "0" "1.321" "1.420" "0.869" "1.638" "1.536" "1.623" "1.226" "1.076" "1.244" "46.4" "61.3" "66.0" "40.3" "76.1" "71.3" "75.4" "56.9" "50.0" "57.8" "" "" "" "" "" "" "" "" "" "" "41.8" "49.6" "59.7" "39.4" "62.8" "71.3" "56.4" "50.3" "44.7" "20.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4288572419513908439" "False" "High" "IsMasterProtein" "Q8WXG6" "MAP kinase-activating death domain protein OS=Homo sapiens OX=9606 GN=MADD PE=1 SV=2" "0.002" "False" "4.043" "1" "1" "1" "1" "1647" "183.2" "6.04" "3.90" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf02141, Pf03456" "8567" "ENSG00000110514" "MADD" "A8K8S7; B5MEE5; D3DQR4; hsa:8567; O15065; O15293; Q15732; Q15741; Q8IWD7; Q8WXG3; Q8WXG4; Q8WXG5; Q8WXG6; Q8WZ63" "Apoptosis modulation and signaling; Deregulation of Rab and Rab effector genes in bladder cancer; TNF-alpha signaling pathway" "" "3" "0" "1.007" "0.790" "0.945" "1.127" "0.859" "1.122" "0.954" "0.939" "1.847" "60.1" "60.6" "47.5" "56.8" "67.8" "51.7" "67.5" "57.4" "56.5" "111.0" "" "" "" "" "" "" "" "" "" "" "54.0" "49.0" "43.0" "55.4" "55.9" "51.7" "50.5" "50.7" "50.5" "39.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5417113921000243817" "False" "High" "IsMasterProtein" "Q5JPI3" "Uncharacterized protein C3orf38 OS=Homo sapiens OX=9606 GN=C3orf38 PE=1 SV=1" "0.002" "False" "4.041" "5" "2" "2" "2" "329" "37.5" "6.47" "5.58" "2" "other biological processes" "nucleus" "" "Pf15008" "285237" "ENSG00000179021" "C3orf38" "B2R8X6; hsa:285237; Q5JPI3; Q8TC85" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5357467251583528977" "False" "High" "IsMasterProtein" "Q49AR2" "UPF0489 protein C5orf22 OS=Homo sapiens OX=9606 GN=C5orf22 PE=1 SV=2" "0.002" "False" "4.040" "4" "1" "1" "1" "442" "49.9" "4.78" "3.23" "1" "" "" "" "Pf12640" "55322" "ENSG00000082213" "C5orf22" "hsa:55322; Q49AR2; Q8ND28; Q8WU61; Q9NUR1" "" "" "0" "0" "0.955" "1.014" "1.005" "0.780" "1.095" "1.051" "0.795" "0.985" "1.386" "45.9" "43.8" "46.6" "46.1" "35.8" "50.3" "48.2" "36.5" "45.2" "63.6" "" "" "" "" "" "" "" "" "" "" "41.3" "35.5" "42.1" "45.0" "29.6" "50.3" "36.1" "32.2" "40.5" "22.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9040602984972190355" "False" "High" "IsMasterProtein" "Q9Y259" "Choline/ethanolamine kinase OS=Homo sapiens OX=9606 GN=CHKB PE=1 SV=3" "0.002" "False" "4.038" "3" "1" "1" "1" "395" "45.2" "5.49" "4.32" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01633" "1120" "ENSG00000100288" "CHKB" "A0PJM6; hsa:1120; Q13388; Q9Y259" "Fatty acid beta-oxidation; Trans-sulfuration, one-carbon metabolism and related pathways; Kennedy pathway from sphingolipids; One-carbon metabolism and related pathways; Glycerolipids and glycerophospholipids" "Synthesis of PC; Synthesis of PE" "7" "0" "1.012" "0.994" "0.886" "1.017" "0.978" "1.136" "1.022" "0.985" "0.807" "146.7" "148.5" "145.9" "130.0" "149.3" "143.5" "166.7" "150.0" "144.5" "118.4" "" "" "" "" "" "" "" "" "" "" "131.9" "120.2" "131.9" "126.9" "123.2" "143.5" "124.8" "132.5" "129.3" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5919366994915360532" "False" "High" "IsMasterProtein" "Q8NI60" "Atypical kinase COQ8A, mitochondrial OS=Homo sapiens OX=9606 GN=COQ8A PE=1 SV=1" "0.002" "False" "4.031" "2" "1" "1" "1" "647" "71.9" "6.99" "3.61" "1" "other metabolic processes" "other membranes;mitochondrion" "kinase activity;other molecular function" "Pf03109" "56997" "ENSG00000163050" "COQ8A" "hsa:56997; Q5T7A5; Q63HK0; Q8NCJ6; Q8NI60; Q9HBQ1; Q9NQ67" "" "" "0" "0" "0.892" "0.944" "0.795" "0.998" "0.869" "0.964" "0.984" "0.855" "0.916" "104.6" "93.4" "98.8" "83.2" "104.5" "90.9" "100.8" "102.9" "89.5" "95.8" "" "" "" "" "" "" "" "" "" "" "94.1" "75.6" "89.3" "81.2" "86.2" "90.9" "75.5" "90.9" "80.1" "34.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8487172372760665544" "False" "High" "IsMasterProtein" "Q6ZSS7" "Major facilitator superfamily domain-containing protein 6 OS=Homo sapiens OX=9606 GN=MFSD6 PE=1 SV=2" "0.002" "False" "4.028" "2" "1" "1" "1" "791" "88.0" "5.53" "3.74" "1" "other biological processes" "plasma membrane;other membranes" "" "Pf12832" "54842" "ENSG00000151690" "MFSD6" "D3KSZ4; hsa:54842; Q6ZSS7; Q86TH2; Q9NXM3" "" "" "0" "0" "0.966" "1.173" "1.277" "1.109" "0.986" "1.096" "0.931" "1.047" "0.516" "16.5" "16.0" "19.4" "21.1" "18.3" "16.3" "18.1" "15.4" "17.3" "8.5" "" "" "" "" "" "" "" "" "" "" "14.9" "12.9" "17.6" "20.6" "15.1" "16.3" "13.6" "13.6" "15.5" "3.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6249152470973198342" "False" "High" "IsMasterProtein" "Q9NYZ3" "G2 and S phase-expressed protein 1 OS=Homo sapiens OX=9606 GN=GTSE1 PE=1 SV=4" "0.002" "False" "4.027" "3" "2" "2" "2" "739" "78.5" "9.23" "5.14" "2" "cell cycle OR cell proliferation;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15259" "51512" "ENSG00000075218" "GTSE1" "B0QYM3; hsa:51512; Q20WK2; Q53GX5; Q5R3I6; Q6DHX4; Q9BRE0; Q9NYZ3; Q9UGZ9; Q9Y557" "" "G2/M Checkpoints; The role of GTSE1 in G2/M progression after G2 checkpoint" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "529818675588363220" "False" "High" "IsMasterProtein" "O95674" "Phosphatidate cytidylyltransferase 2 OS=Homo sapiens OX=9606 GN=CDS2 PE=1 SV=1" "0.002" "False" "4.027" "3" "1" "1" "1" "445" "51.4" "7.09" "4.68" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf01148" "8760" "ENSG00000101290" "CDS2" "B2RDC6; D3DW04; hsa:8760; O95674; Q5TDY2; Q5TDY3; Q5TDY4; Q5TDY5; Q9BYK5; Q9NTT2" "" "Synthesis of PG" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1224682826513998034" "False" "High" "IsMasterProtein" "O00255" "Menin OS=Homo sapiens OX=9606 GN=MEN1 PE=1 SV=5" "0.002" "False" "4.025" "2" "1" "1" "1" "610" "67.5" "6.55" "2.68" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05053" "4221" "ENSG00000133895" "MEN1" "A5HBC6; A5HBC7; A5HBC8; A5HBC9; A5HBD0; A5HBD1; A5HBD2; O00255; O00632; Q9BUF0; Q9BUK2" "10q11.21q11.23 copy number variation syndrome" "RHO GTPases activate IQGAPs; Formation of WDR5-containing histone-modifying complexes; Formation of the beta-catenin:TCF transactivating complex; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Deactivation of the beta-catenin transactivating complex; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2010666374773995606" "False" "High" "IsMasterProtein" "Q06587" "E3 ubiquitin-protein ligase RING1 OS=Homo sapiens OX=9606 GN=RING1 PE=1 SV=2" "0.002" "False" "4.025" "4" "1" "1" "1" "406" "42.4" "5.62" "3.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00097, Pf16207" "6015" "ENSG00000204227; ENSG00000206287; ENSG00000226788; ENSG00000228520; ENSG00000231115; ENSG00000235107" "RING1" "A8JZZ0; Q06587; Q5JP96; Q5SQW2; Q86V19" "Pleural mesothelioma; Notch signaling pathway" "Regulation of PTEN gene transcription; Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Transcriptional Regulation by E2F6" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2945002004547854697" "False" "High" "IsMasterProtein" "Q8N7B6" "PACRG-like protein OS=Homo sapiens OX=9606 GN=PACRGL PE=1 SV=2" "0.002" "False" "4.022" "5" "1" "1" "1" "248" "27.1" "9.67" "4.49" "1" "" "" "" "Pf10274" "133015" "ENSG00000163138" "PACRGL" "B2RDB9; B4DFF8; B4DMN7; hsa:133015; Q8N7B6; Q8TBA8" "" "" "0" "0" "1.014" "0.908" "1.082" "1.023" "1.016" "1.152" "1.219" "1.009" "0.882" "49.1" "49.7" "44.5" "53.1" "50.2" "49.8" "56.5" "59.8" "49.5" "43.3" "" "" "" "" "" "" "" "" "" "" "44.1" "40.2" "40.3" "51.8" "41.4" "49.8" "42.3" "52.8" "44.3" "15.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1106391379852214598" "False" "High" "IsMasterProtein" "Q8NAG6" "Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKLE1 PE=1 SV=2" "0.002" "False" "4.017" "2" "1" "1" "1" "615" "66.8" "6.43" "3.91" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;transport;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796" "126549" "ENSG00000160117" "ANKLE1" "A8VU82; hsa:126549; Q8N8J8; Q8NAG6" "" "" "0" "0" "1.101" "1.124" "1.124" "1.287" "1.437" "1.282" "1.002" "1.116" "3.379" "41.5" "45.7" "46.6" "46.6" "53.4" "59.6" "53.2" "41.6" "46.3" "140.2" "" "" "" "" "" "" "" "" "" "" "37.3" "37.0" "42.2" "45.5" "44.1" "59.6" "39.8" "36.7" "41.4" "50.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8213530415283437885" "False" "High" "IsMasterProtein" "Q9Y2R0" "Cytochrome c oxidase assembly factor 3 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COA3 PE=1 SV=1" "0.002" "False" "4.017" "8" "1" "2" "1" "106" "11.7" "9.60" "8.10" "1" "cell organization and biogenesis;other biological processes" "other membranes;mitochondrion" "" "Pf09813" "28958" "ENSG00000183978" "COA3" "A8K498; hsa:28958; Q9Y2R0" "Mitochondrial complex IV assembly; Arsenic metabolism and reactive oxygen species generation" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5772748486031489240" "False" "High" "IsMasterProtein" "Q9Y3R5" "Protein dopey-2 OS=Homo sapiens OX=9606 GN=DOP1B PE=1 SV=5" "0.002" "False" "4.017" "1" "2" "2" "2" "2298" "258.1" "6.29" "5.67" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf04118" "9980" "ENSG00000142197" "DOP1B" "D3DSG5; hsa:9980; Q6PJQ7; Q9UEZ3; Q9Y3R5" "" "" "0" "0" "0.990" "1.006" "1.159" "1.029" "0.813" "1.294" "1.166" "0.962" "0.927" "169.7" "168.0" "170.8" "196.7" "174.6" "138.1" "219.6" "197.8" "163.3" "157.3" "" "" "" "" "" "" "" "" "" "" "152.6" "135.9" "154.5" "192.0" "144.1" "138.1" "164.4" "174.7" "146.2" "56.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7030839673765711891" "False" "High" "IsMasterProtein" "Q9HC44" "Vasculin-like protein 1 OS=Homo sapiens OX=9606 GN=GPBP1L1 PE=1 SV=1" "0.002" "False" "4.016" "4" "1" "1" "1" "474" "52.3" "6.84" "3.56" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf15337" "60313" "ENSG00000159592" "GPBP1L1" "D3DQ10; hsa:60313; Q9H751; Q9HC44" "" "" "0" "0" "0.877" "0.887" "0.864" "0.935" "1.144" "1.134" "0.970" "1.035" "0.949" "54.6" "47.9" "48.4" "47.1" "51.0" "62.5" "61.9" "52.9" "56.5" "51.8" "" "" "" "" "" "" "" "" "" "" "49.1" "38.8" "43.8" "46.0" "42.1" "62.5" "46.4" "46.8" "50.6" "18.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5255627558337460948" "False" "High" "IsMasterProtein" "Q8N3F0" "Maturin OS=Homo sapiens OX=9606 GN=MTURN PE=1 SV=2" "0.002" "False" "4.001" "13" "1" "1" "1" "131" "14.9" "4.17" "4.12" "1" "other biological processes" "other cell component" "" "Pf15167" "222166" "ENSG00000180354" "MTURN" "B8ZZW9; hsa:222166; Q8N3F0; Q8N791; Q8N8M4; Q8NEX2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-946997143680763818" "False" "High" "IsMasterProtein" "Q8TDG4" "Helicase POLQ-like OS=Homo sapiens OX=9606 GN=HELQ PE=1 SV=2" "0.002" "False" "4.000" "1" "1" "2" "1" "1101" "124.1" "6.58" "7.03" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf20470, Pf21099" "113510" "ENSG00000163312" "HELQ" "hsa:113510; Q05DF9; Q502W9; Q659B8; Q6ZQX4; Q6ZTS4; Q8TDG4; Q96EX7" "Primary ovarian insufficiency" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4731047404195791293" "False" "High" "IsMasterProtein" "Q8IXW5" "Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 OS=Homo sapiens OX=9606 GN=RPAP2 PE=1 SV=1" "0.002" "False" "3.989" "2" "1" "1" "1" "612" "69.5" "7.78" "3.40" "1" "RNA metabolism OR transcription;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf04181" "79871" "ENSG00000122484" "RPAP2" "C9JKB5; hsa:79871; Q49AS7; Q8IXW5; Q9H8Y2" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.324" "1.049" "1.201" "0.911" "1.162" "0.934" "1.103" "1.156" "1.369" "56.5" "74.8" "59.3" "67.8" "51.5" "65.6" "52.8" "62.3" "65.3" "77.3" "" "" "" "" "" "" "" "" "" "" "50.8" "60.5" "53.6" "66.2" "42.5" "65.6" "39.5" "55.0" "58.4" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8889499803111270787" "False" "High" "IsMasterProtein" "O43824" "Putative GTP-binding protein 6 OS=Homo sapiens OX=9606 GN=GTPBP6 PE=1 SV=4" "0.002" "False" "3.985" "2" "1" "1" "1" "516" "56.9" "9.42" "4.15" "1" "" "other cell component" "translation activity;other molecular function" "Pf01926, Pf13167, Pf16360" "8225" "ENSG00000178605; ENSG00000292358" "GTPBP6" "H0Y2S1; hsa:8225; O43824; Q53F77; Q5HYX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2068779671623766038" "False" "High" "IsMasterProtein" "A6NJ78" "12S rRNA N4-methylcytidine (m4C) methyltransferase OS=Homo sapiens OX=9606 GN=METTL15 PE=1 SV=1" "0.002" "False" "3.981" "3" "1" "1" "1" "407" "46.1" "8.62" "3.47" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf01795" "196074" "ENSG00000169519" "METTL15" "A6NJ78; A8MRS5; B7WNU2; hsa:196074; Q3MHD3; Q8N601; Q8NBA7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3691090388992879642" "False" "High" "IsMasterProtein" "Cont_P02453" "Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3" "0.002" "True" "3.974" "1" "1" "1" "1" "1463" "138.9" "5.78" "4.16" "1" "cell organization and biogenesis;other metabolic processes;transport;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "extracellular structural activity;other molecular function" "Pf00093, Pf01391, Pf01410" "104990617; 109573749; 282187" "ENSBIXG00000001136; ENSBTAG00000013103" "COL1A1" "A0A4W2CI58; A0A6B0RVL7; A0A6P3HPH0; A0A6P5DEQ2; bbis:104990617; biu:109573749; bta:282187; P02453; Q3MHM2" "Inflammatory response pathway; Osteoblast signaling; Focal adhesion" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Cell surface interactions at the vascular wall; Integrin cell surface interactions; ECM proteoglycans; MET activates PTK2 signaling; Collagen degradation; Crosslinking of collagen fibrils; Non-integrin membrane-ECM interactions; Collagen chain trimerization; GPVI-mediated activation cascade; Platelet Aggregation (Plug Formation); Platelet Adhesion to exposed collagen; GP1b-IX-V activation signalling" "19" "0" "1.231" "1.000" "1.718" "1.008" "0.883" "0.691" "0.630" "0.485" "0.698" "37.0" "45.5" "37.0" "63.5" "37.3" "32.7" "25.6" "23.3" "17.9" "25.8" "" "" "" "" "" "" "" "" "" "" "33.3" "36.8" "33.5" "62.0" "30.8" "32.7" "19.1" "20.6" "16.1" "9.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6853510993854323375" "False" "High" "IsMasterProtein" "Q9H7J1" "Protein phosphatase 1 regulatory subunit 3E OS=Homo sapiens OX=9606 GN=PPP1R3E PE=1 SV=2" "0.002" "False" "3.973" "7" "1" "1" "1" "279" "30.6" "11.15" "4.49" "1" "other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf03370" "90673" "ENSG00000235194" "PPP1R3E" "D3DS47; hsa:90673; Q9H7J1" "" "" "0" "0" "1.443" "0.812" "0.900" "0.946" "1.104" "0.940" "1.130" "0.757" "0.941" "15.5" "22.3" "12.5" "13.9" "14.6" "17.1" "14.5" "17.5" "11.7" "14.5" "" "" "" "" "" "" "" "" "" "" "13.9" "18.1" "11.4" "13.6" "12.1" "17.1" "10.9" "15.4" "10.5" "5.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6896293366325971592" "False" "High" "IsMasterProtein" "Q8WWK9" "Cytoskeleton-associated protein 2 OS=Homo sapiens OX=9606 GN=CKAP2 PE=1 SV=1" "0.002" "False" "3.966" "3" "2" "2" "2" "683" "76.9" "9.41" "5.62" "2" "cell cycle OR cell proliferation;other biological processes" "cytoskeleton;other cell component" "" "Pf15297" "26586" "ENSG00000136108" "CKAP2" "A2BDE0; A5YM58; B4DR35; E9PD90; hsa:26586; Q3KRA5; Q5VXB4; Q8IWV5; Q8IWV6; Q8WWK9; Q96FH9; Q9H012; Q9H0D0; Q9H988; Q9HC49; Q9NVG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-300411415202382779" "False" "High" "IsMasterProtein" "Q96NB1" "Centrosomal protein 20 OS=Homo sapiens OX=9606 GN=CEP20 PE=1 SV=1" "0.002" "False" "3.963" "11" "2" "2" "2" "174" "19.8" "7.15" "3.25" "2" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf09398" "123811" "ENSG00000133393; ENSG00000276914" "CEP20" "B3KPU9; hsa:123811; Q96NB1" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "1.191" "1.074" "1.203" "1.316" "1.263" "1.128" "1.146" "0.988" "1.019" "103.8" "123.6" "111.5" "124.9" "136.6" "131.0" "117.0" "119.0" "102.6" "105.7" "" "" "" "" "" "" "" "" "" "" "93.3" "100.0" "100.8" "121.9" "112.7" "131.0" "87.6" "105.1" "91.8" "37.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1731274812714259147" "False" "High" "IsMasterProtein" "Q9NYJ8" "TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Homo sapiens OX=9606 GN=TAB2 PE=1 SV=1" "0.002" "False" "3.959" "3" "2" "2" "2" "693" "76.4" "8.54" "6.55" "2" "stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02845" "23118" "ENSG00000055208" "TAB2" "B2RCC4; E1P5A0; hsa:23118; O94838; Q6I9W8; Q76N06; Q9NYJ8; Q9UFP7" "IL-1 signaling pathway; RANKL/RANK signaling pathway; TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; TLR4 signaling and tolerance; Exercise-induced circadian regulation; miRNA role in immune response in sepsis; Measles virus infection; Hepatitis B infection; Toll-like receptor signaling pathway" "Downstream TCR signaling; NOD1/2 Signaling Pathway; activated TAK1 mediates p38 MAPK activation; SARS-CoV-2 activates/modulates innate and adaptive immune responses; FCERI mediated NF-kB activation; CLEC7A (Dectin-1) signaling; TRAF6-mediated induction of TAK1 complex within TLR4 complex; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation; Nuclear signaling by ERBB4; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; TAK1-dependent IKK and NF-kappa-B activation ; TNFR1-induced NF-kappa-B signaling pathway; TICAM1,TRAF6-dependent induction of TAK1 complex; IRAK2 mediated activation of TAK1 complex; Alpha-protein kinase 1 signaling pathway" "27" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7498924071980765815" "False" "High" "IsMasterProtein" "Q9Y2G3" "Phospholipid-transporting ATPase IF OS=Homo sapiens OX=9606 GN=ATP11B PE=1 SV=2" "0.002" "False" "3.958" "1" "1" "1" "1" "1177" "134.1" "6.96" "3.67" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf00702, Pf13246, Pf16209, Pf16212" "23200" "ENSG00000058063" "ATP11B" "hsa:23200; Q96FN1; Q9UKK7; Q9Y2G3" "" "Neutrophil degranulation; Ion transport by P-type ATPases" "2" "0" "0.952" "0.904" "0.794" "0.935" "0.761" "0.810" "0.931" "0.631" "0.939" "52.2" "49.6" "47.2" "41.4" "48.8" "39.7" "42.2" "48.6" "32.9" "49.0" "" "" "" "" "" "" "" "" "" "" "46.9" "40.2" "42.7" "40.4" "40.2" "39.7" "31.6" "42.9" "29.5" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2897995846121451924" "False" "High" "IsMasterProtein" "Q9Y3B1" "PRELI domain containing protein 3B OS=Homo sapiens OX=9606 GN=PRELID3B PE=1 SV=2" "0.002" "False" "3.956" "7" "1" "1" "1" "194" "21.5" "6.73" "3.46" "1" "cell organization and biogenesis;transport" "mitochondrion" "transporter activity" "Pf04707" "51012" "ENSG00000101166" "PRELID3B" "E1P5I8; hsa:51012; Q5JX17; Q9NUL0; Q9Y3B1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3186791909088934819" "False" "High" "IsMasterProtein" "Q96JB2" "Conserved oligomeric Golgi complex subunit 3 OS=Homo sapiens OX=9606 GN=COG3 PE=1 SV=3" "0.002" "False" "3.954" "1" "1" "1" "1" "828" "94.0" "5.57" "4.89" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi" "" "Pf04136, Pf20671" "83548" "ENSG00000136152" "COG3" "B2RAW5; hsa:83548; Q5VT70; Q8IXX4; Q96JB2; Q9BZ92" "" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network; COPI-mediated anterograde transport" "3" "0" "1.126" "1.028" "0.832" "0.956" "1.021" "0.896" "0.916" "0.856" "3.040" "63.9" "72.0" "65.8" "53.2" "61.2" "65.3" "57.3" "58.6" "54.8" "194.4" "" "" "" "" "" "" "" "" "" "" "57.5" "58.3" "59.5" "52.0" "50.5" "65.3" "42.9" "51.7" "49.0" "69.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6256075444160653012" "False" "High" "IsMasterProtein" "Q5SVZ6" "Zinc finger MYM-type protein 1 OS=Homo sapiens OX=9606 GN=ZMYM1 PE=1 SV=1" "0.002" "False" "3.954" "1" "1" "1" "1" "1142" "128.6" "7.44" "3.36" "1" "" "nucleus" "other molecular function" "Pf05699, Pf06467, Pf14291" "79830" "ENSG00000197056" "ZMYM1" "D3DPR7; hsa:79830; Q5SVZ6; Q7Z3Q4" "" "" "0" "0" "1.226" "1.009" "0.828" "0.994" "1.698" "0.953" "1.348" "1.041" "1.651" "16.5" "20.2" "16.6" "13.6" "16.4" "27.9" "15.7" "22.2" "17.1" "27.2" "" "" "" "" "" "" "" "" "" "" "14.8" "16.3" "15.0" "13.3" "13.5" "27.9" "11.7" "19.6" "15.3" "9.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7187364612041296451" "False" "High" "IsMasterProtein" "Q96Q05" "Trafficking protein particle complex subunit 9 OS=Homo sapiens OX=9606 GN=TRAPPC9 PE=1 SV=2" "0.002" "False" "3.952" "1" "1" "1" "1" "1148" "128.4" "6.62" "4.14" "1" "cell organization and biogenesis;transport;developmental processes" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf08626" "83696" "ENSG00000167632" "TRAPPC9" "hsa:83696; Q4VTT3; Q658K7; Q6P149; Q6ZQT3; Q7L5C4; Q86Y21; Q96Q05; Q96SL2; Q9BQA2" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8117817819398789718" "False" "High" "IsMasterProtein" "Q9P2X3" "Protein IMPACT OS=Homo sapiens OX=9606 GN=IMPACT PE=1 SV=2" "0.002" "False" "3.946" "6" "1" "1" "1" "320" "36.5" "4.97" "3.78" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "other cell component" "cytoskeletal activity;translation activity;other molecular function" "Pf01205, Pf05773" "55364" "ENSG00000154059" "IMPACT" "A8MXG0; hsa:55364; Q49AM0; Q9H2X4; Q9P2X3" "" "Response of EIF2AK4 (GCN2) to amino acid deficiency" "1" "0" "0.816" "0.866" "0.761" "0.943" "0.865" "0.737" "0.908" "0.866" "0.800" "96.5" "78.7" "83.5" "73.4" "90.9" "83.4" "71.1" "87.6" "83.5" "77.2" "" "" "" "" "" "" "" "" "" "" "86.7" "63.7" "75.5" "71.6" "75.0" "83.4" "53.2" "77.4" "74.7" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2121660018572641519" "False" "High" "IsMasterProtein" "Q9Y6I9" "Testis-expressed protein 264 OS=Homo sapiens OX=9606 GN=TEX264 PE=1 SV=1" "0.002" "False" "3.942" "4" "1" "1" "1" "313" "34.2" "4.86" "4.64" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response" "non-structural extracellular;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "" "51368" "ENSG00000164081" "TEX264" "B3KN87; hsa:51368; Q9UKD7; Q9Y6I9" "" "Platelet degranulation" "1" "0" "1.076" "1.117" "0.955" "1.228" "1.144" "1.233" "1.150" "0.867" "0.764" "55.4" "59.6" "61.9" "52.9" "68.1" "63.4" "68.3" "63.8" "48.1" "42.4" "" "" "" "" "" "" "" "" "" "" "49.8" "48.2" "56.0" "51.7" "56.2" "63.4" "51.2" "56.3" "43.0" "15.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8450189262583768708" "False" "High" "IsMasterProtein" "Q96NT0" "Coiled-coil domain-containing protein 115 OS=Homo sapiens OX=9606 GN=CCDC115 PE=1 SV=1" "0.002" "False" "3.925" "7" "1" "1" "1" "180" "19.7" "6.95" "3.78" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf21730" "84317" "ENSG00000136710" "CCDC115" "B4DJ47; hsa:84317; Q96NT0; Q9BR88" "" "RHOA GTPase cycle" "1" "0" "1.161" "1.167" "1.064" "1.109" "1.172" "1.139" "1.128" "0.978" "1.153" "62.5" "72.6" "73.0" "66.5" "69.3" "73.3" "71.2" "70.5" "61.2" "72.1" "" "" "" "" "" "" "" "" "" "" "56.2" "58.7" "66.0" "65.0" "57.2" "73.3" "53.3" "62.3" "54.7" "25.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2036187621347807091" "False" "High" "IsMasterProtein" "P23469" "Receptor-type tyrosine-protein phosphatase epsilon OS=Homo sapiens OX=9606 GN=PTPRE PE=1 SV=1" "0.002" "False" "3.924" "2" "1" "1" "1" "700" "80.6" "7.02" "4.16" "1" "protein metabolism;other metabolic processes;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00102" "5791" "ENSG00000132334" "PTPRE" "hsa:5791; P23469; Q13345; Q5VWH3; Q5VWH4; Q96KQ6" "" "" "0" "0" "1.035" "1.004" "0.928" "1.171" "1.032" "1.179" "0.933" "1.147" "0.990" "104.7" "108.4" "105.1" "97.2" "122.7" "108.1" "123.5" "97.7" "120.1" "103.7" "" "" "" "" "" "" "" "" "" "" "94.2" "87.8" "95.1" "94.9" "101.3" "108.1" "92.5" "86.3" "107.5" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6498746836985135124" "False" "High" "IsMasterProtein" "C9J7I0" "UBAP1-MVB12-associated (UMA)-domain containing protein 1 OS=Homo sapiens OX=9606 GN=UMAD1 PE=1 SV=2" "0.002" "False" "3.923" "10" "1" "2" "1" "137" "15.2" "4.48" "5.78" "1" "" "" "" "" "729852" "ENSG00000219545" "UMAD1" "A4D104; C9J7I0; hsa:729852" "" "" "0" "0" "1.043" "1.019" "1.054" "1.165" "1.143" "0.903" "1.036" "1.180" "0.961" "79.0" "82.3" "80.4" "83.2" "92.0" "90.2" "71.3" "81.8" "93.2" "75.9" "" "" "" "" "" "" "" "" "" "" "71.0" "66.6" "72.7" "81.2" "75.9" "90.2" "53.4" "72.3" "83.4" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2190048182398586679" "False" "High" "IsMasterProtein" "Q9NRX5" "Serine incorporator 1 OS=Homo sapiens OX=9606 GN=SERINC1 PE=1 SV=1" "0.002" "False" "3.922" "3" "1" "1" "1" "453" "50.5" "5.85" "3.09" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf03348" "57515" "ENSG00000111897" "SERINC1" "B3KY69; E1P565; hsa:57515; O75655; Q7Z2F5; Q8TAG1; Q9NRX5; Q9NTH8; Q9ULG7" "Sphingolipid pathway" "Serine biosynthesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6959093533306709871" "False" "High" "IsMasterProtein" "P0DPD7" "EEF1A lysine methyltransferase 4 OS=Homo sapiens OX=9606 GN=EEF1AKMT4 PE=1 SV=1" "0.002" "False" "3.919" "6" "1" "1" "1" "255" "28.3" "6.05" "4.02" "1" "other metabolic processes" "" "other molecular function" "Pf08241" "110599564" "ENSG00000284753" "EEF1AKMT4" "A5PLK8; hsa:110599564; O60344; P0DPD7; Q6NTG7; Q6UW36; Q8NFD7; Q96NX3; Q96NX4; Q9BRZ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9101384525569952634" "False" "High" "IsMasterProtein" "Q9BZF1" "Oxysterol-binding protein-related protein 8 OS=Homo sapiens OX=9606 GN=OSBPL8 PE=1 SV=3" "0.002" "False" "3.917" "2" "2" "3" "2" "889" "101.1" "6.96" "5.07" "2" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00169, Pf01237" "114882" "ENSG00000091039" "OSBPL8" "A8K1T2; E9PE66; E9PE68; hsa:114882; Q52LQ3; Q68D75; Q8WXP8; Q9BZF1; Q9P277" "" "Acyl chain remodelling of PS" "1" "0" "1.029" "0.895" "1.086" "1.020" "1.069" "1.192" "0.916" "0.879" "1.229" "295.9" "304.5" "264.8" "321.5" "302.0" "316.4" "352.7" "271.1" "260.2" "363.6" "" "" "" "" "" "" "" "" "" "" "266.1" "246.4" "239.5" "313.8" "249.2" "316.4" "264.1" "239.4" "232.8" "129.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1842086300853461210" "False" "High" "IsMasterProtein" "Q9ULL1" "Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens OX=9606 GN=PLEKHG1 PE=1 SV=2" "0.002" "False" "3.909" "1" "1" "2" "1" "1385" "155.3" "6.24" "5.96" "1" "other biological processes" "cytosol;nucleus" "enzyme regulator activity;other molecular function" "Pf00169, Pf00621" "57480" "ENSG00000120278" "PLEKHG1" "hsa:57480; Q5T1F2; Q9ULL1" "Opioid receptor pathways" "CDC42 GTPase cycle; RAC1 GTPase cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4322525870373486427" "False" "High" "IsMasterProtein" "P18433" "Receptor-type tyrosine-protein phosphatase alpha OS=Homo sapiens OX=9606 GN=PTPRA PE=1 SV=3" "0.002" "False" "3.907" "3" "2" "2" "2" "802" "90.7" "6.65" "2.95" "2" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00102" "5786" "ENSG00000132670" "PTPRA" "A8K2G8; D3DVX5; hsa:5786; P18433; Q14513; Q7Z2I2; Q96TD9" "Microtubule cytoskeleton regulation; Spinal cord injury" "NCAM signaling for neurite out-growth; RAF/MAP kinase cascade" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3530814954955127226" "False" "High" "IsMasterProtein" "Q9UKV0" "Histone deacetylase 9 OS=Homo sapiens OX=9606 GN=HDAC9 PE=1 SV=2" "0.002" "False" "3.905" "3" "2" "2" "2" "1011" "111.2" "6.89" "2.76" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00850, Pf12203" "9734" "ENSG00000048052" "HDAC9" "A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0; hsa:9734; O94845; O95028; Q2M2R6; Q86SL1; Q86US3; Q9UKV0" "MicroRNAs in cardiomyocyte hypertrophy; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; HDAC6 interactions in the central nervous system; Sudden infant death syndrome (SIDS) susceptibility pathways" "Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8030934540585171981" "False" "High" "IsMasterProtein" "Q9UJT0" "Tubulin epsilon chain OS=Homo sapiens OX=9606 GN=TUBE1 PE=1 SV=1" "0.002" "False" "3.902" "2" "1" "1" "1" "475" "52.9" "6.64" "4.04" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00091, Pf03953" "51175" "ENSG00000074935" "TUBE1" "hsa:51175; Q5H8W8; Q8NEG3; Q9UJT0" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "1.068" "0.993" "0.731" "0.967" "0.928" "0.894" "0.875" "0.994" "1.037" "88.2" "94.2" "87.7" "64.5" "85.3" "81.9" "78.9" "77.2" "87.7" "91.5" "" "" "" "" "" "" "" "" "" "" "79.3" "76.2" "79.3" "63.0" "70.4" "81.9" "59.1" "68.2" "78.5" "32.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8594684179756660612" "False" "High" "IsMasterProtein" "O77932" "Decapping and exoribonuclease protein OS=Homo sapiens OX=9606 GN=DXO PE=1 SV=2" "0.002" "False" "3.901" "4" "1" "1" "1" "396" "44.9" "7.69" "5.73" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf08652" "1797" "ENSG00000204348; ENSG00000206346; ENSG00000224313; ENSG00000225682; ENSG00000234798; ENSG00000236765" "DXO" "A2CER3; B0UZ80; hsa:1797; O15004; O77932; O78127; O78128; Q5ST60; Q6IPZ2; Q9NPK4" "" "" "0" "0" "1.079" "0.957" "1.118" "1.131" "1.058" "1.033" "1.105" "0.947" "1.227" "144.6" "156.1" "138.4" "161.7" "163.6" "153.0" "149.4" "159.8" "136.9" "177.4" "" "" "" "" "" "" "" "" "" "" "130.0" "126.3" "125.2" "157.9" "135.0" "153.0" "111.9" "141.1" "122.5" "63.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5378807455886263528" "False" "High" "IsMasterProtein" "Q13740" "CD166 antigen OS=Homo sapiens OX=9606 GN=ALCAM PE=1 SV=2" "0.002" "False" "3.901" "2" "1" "1" "1" "583" "65.1" "6.25" "3.64" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf08205, Pf13927" "214" "ENSG00000170017" "ALCAM" "B2RNS3; B4DTU0; hsa:214; O60892; Q13740; Q1HGM8; Q1HGM9; Q6PEY4; Q6ZS95" "" "L1CAM interactions" "1" "0" "0.946" "0.794" "1.122" "0.918" "0.893" "0.990" "0.835" "0.985" "0.904" "97.1" "91.9" "77.1" "109.0" "89.1" "86.8" "96.1" "81.1" "95.7" "87.8" "" "" "" "" "" "" "" "" "" "" "87.3" "74.3" "69.8" "106.4" "73.6" "86.8" "72.0" "71.6" "85.6" "31.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5366408655713326940" "False" "High" "IsMasterProtein" "Q07817" "Bcl-2-like protein 1 OS=Homo sapiens OX=9606 GN=BCL2L1 PE=1 SV=1" "0.002" "False" "3.901" "4" "1" "1" "1" "233" "26.0" "4.93" "3.59" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00452, Pf02180" "598" "ENSG00000171552" "BCL2L1" "E1P5L6; hsa:598; Q07817; Q5CZ89; Q5TE65; Q92976" "Leptin signaling pathway; IL-7 signaling pathway; TNF-alpha signaling pathway; Amyotrophic lateral sclerosis (ALS); Apoptosis; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); IL-3 signaling pathway; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; lncRNA-mediated mechanisms of therapeutic resistance; Regulation of apoptosis by parathyroid hormone-related protein; VEGFA-VEGFR2 signaling; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; IL-18 signaling pathway; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis" "Interleukin-4 and Interleukin-13 signaling; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; RAS processing; NFE2L2 regulating tumorigenic genes; The NLRP1 inflammasome; STAT5 activation downstream of FLT3 ITD mutants; SARS-CoV-1-mediated effects on programmed cell death" "32" "0" "0.931" "1.064" "1.047" "0.958" "0.949" "0.964" "0.945" "1.059" "1.040" "65.2" "60.7" "69.4" "68.2" "62.5" "61.9" "62.8" "61.6" "69.0" "67.8" "" "" "" "" "" "" "" "" "" "" "58.6" "49.1" "62.7" "66.6" "51.5" "61.9" "47.1" "54.4" "61.8" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5401388015032906251" "False" "High" "IsMasterProtein" "O95402" "Mediator of RNA polymerase II transcription subunit 26 OS=Homo sapiens OX=9606 GN=MED26 PE=1 SV=2" "0.002" "False" "3.900" "2" "1" "1" "1" "600" "65.4" "9.16" "4.44" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf08711, Pf15693, Pf15694" "9441" "ENSG00000105085" "MED26" "A1A4S3; hsa:9441; O95402; Q0VGB6" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions; Generic Transcription Pathway" "4" "0" "1.080" "1.022" "0.962" "1.008" "0.896" "0.973" "0.912" "0.858" "1.088" "56.3" "60.8" "57.5" "54.2" "56.8" "50.5" "54.8" "51.4" "48.3" "61.3" "" "" "" "" "" "" "" "" "" "" "50.6" "49.2" "52.0" "52.9" "46.8" "50.5" "41.0" "45.4" "43.2" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3032211375385727038" "False" "High" "IsMasterProtein" "Q15388" "Mitochondrial import receptor subunit TOM20 homolog OS=Homo sapiens OX=9606 GN=TOMM20 PE=1 SV=1" "0.002" "False" "3.898" "9" "1" "1" "1" "145" "16.3" "8.60" "3.56" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytoskeleton;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf02064" "9804" "ENSG00000173726" "TOMM20" "A8K195; hsa:9804; Q15388; Q498B3; Q6IBT4" "" "Ub-specific processing proteases; Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "3" "0" "1.185" "0.864" "0.840" "1.198" "0.906" "1.130" "1.027" "0.822" "0.716" "31.4" "37.3" "27.2" "26.4" "37.7" "28.5" "35.5" "32.3" "25.8" "22.5" "" "" "" "" "" "" "" "" "" "" "28.3" "30.1" "24.6" "25.8" "31.1" "28.5" "26.6" "28.5" "23.1" "8.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "896228887821211438" "False" "High" "IsMasterProtein" "P58004" "Sestrin-2 OS=Homo sapiens OX=9606 GN=SESN2 PE=1 SV=1" "0.002" "False" "3.897" "4" "2" "2" "2" "480" "54.5" "5.90" "5.68" "2" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf04636" "83667" "ENSG00000130766; ENSG00000285069" "SESN2" "hsa:83667; P58004; Q5T7D0; Q96SI5" "Head and neck squamous cell carcinoma; p53 transcriptional gene network" "KEAP1-NFE2L2 pathway; Amino acids regulate mTORC1; TP53 Regulates Metabolic Genes" "5" "0" "0.908" "0.802" "0.847" "0.975" "0.793" "1.170" "1.014" "0.861" "1.666" "13.5" "12.3" "10.8" "11.4" "13.2" "10.7" "15.8" "13.7" "11.6" "22.5" "" "" "" "" "" "" "" "" "" "" "12.1" "9.9" "9.8" "11.2" "10.9" "10.7" "11.8" "12.1" "10.4" "8.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4819084498940790760" "False" "High" "IsMasterProtein" "Q6ZVM7" "TOM1-like protein 2 OS=Homo sapiens OX=9606 GN=TOM1L2 PE=1 SV=1" "0.002" "False" "3.894" "2" "1" "1" "1" "507" "55.5" "4.79" "3.92" "1" "transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00790, Pf03127" "146691" "ENSG00000175662" "TOM1L2" "B7Z2L7; B7Z7F4; hsa:146691; Q6ZVM7; Q86V61; Q8TDE7; Q96M88" "Smith-Magenis and Potocki-Lupski syndrome copy number variation" "" "1" "0" "1.059" "1.204" "1.053" "1.224" "1.004" "1.149" "1.207" "1.279" "1.250" "71.4" "75.6" "85.9" "75.2" "87.4" "71.6" "82.0" "86.2" "91.3" "89.3" "" "" "" "" "" "" "" "" "" "" "64.2" "61.1" "77.7" "73.4" "72.1" "71.6" "61.4" "76.1" "81.7" "31.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6689030380433317187" "False" "High" "IsMasterProtein" "Q01543" "Friend leukemia integration 1 transcription factor OS=Homo sapiens OX=9606 GN=FLI1 PE=1 SV=1" "0.002" "False" "3.887" "2" "1" "1" "1" "452" "51.0" "7.06" "2.98" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198" "2313" "ENSG00000151702" "FLI1" "B2R8H2; B4DFV4; B4DTC6; G3V183; hsa:2313; Q01543; Q14319; Q92480; Q9UE07" "Hematopoietic stem cell differentiation" "Transcriptional regulation of granulopoiesis" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-8275820454411589683" "False" "High" "IsMasterProtein" "Cont_P41361" "Antithrombin-III OS=Bos taurus OX=9913 GN=SERPINC1 PE=1 SV=2" "0.002" "True" "3.884" "4" "2" "2" "2" "465" "52.3" "7.33" "3.39" "2" "stress response;other biological processes" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00079" "540261" "" "SERPINC1" "bta:540261; P41361; Q3SZQ7" "" "" "0" "0" "1.148" "1.053" "0.934" "1.114" "0.940" "1.099" "0.949" "0.869" "0.860" "162.2" "186.1" "170.7" "151.4" "180.6" "152.4" "178.2" "153.9" "140.9" "139.4" "" "" "" "" "" "" "" "" "" "" "145.8" "150.6" "154.4" "147.8" "149.0" "152.4" "133.4" "135.9" "126.0" "49.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4512542596092401927" "False" "High" "IsMasterProtein" "Q15390" "Mitochondrial fission regulator 1 OS=Homo sapiens OX=9606 GN=MTFR1 PE=1 SV=2" "0.002" "False" "3.883" "3" "1" "1" "1" "333" "37.0" "9.01" "3.45" "1" "cell organization and biogenesis;other metabolic processes" "plasma membrane;other membranes;cytosol;mitochondrion" "" "Pf05308" "9650" "ENSG00000066855" "MTFR1" "E7EP84; hsa:9650; Q15390; Q6IB94; Q7Z669; Q86XH5; Q8IVD7" "" "" "0" "0" "0.930" "0.870" "0.896" "1.004" "0.829" "1.171" "0.979" "0.949" "0.803" "125.9" "117.1" "109.6" "112.8" "126.4" "104.3" "147.4" "123.2" "119.5" "101.2" "" "" "" "" "" "" "" "" "" "" "113.2" "94.7" "99.1" "110.1" "104.3" "104.3" "110.4" "108.8" "106.9" "36.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-595195611333243081" "False" "High" "IsMasterProtein" "O15265" "Ataxin-7 OS=Homo sapiens OX=9606 GN=ATXN7 PE=1 SV=1" "0.002" "False" "3.879" "2" "1" "1" "1" "892" "95.4" "9.85" "2.95" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf08313" "6314" "ENSG00000163635" "ATXN7" "B4E207; E9PHP9; hsa:6314; O15265; O75328; O75329; Q9Y6P8" "" "Ub-specific processing proteases; HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "High" "Not Found" "Not Found" "Not Found" "1" "" "-8514110242710764604" "False" "High" "IsMasterProtein" "P48553" "Trafficking protein particle complex subunit 10 OS=Homo sapiens OX=9606 GN=TRAPPC10 PE=1 SV=2" "0.002" "False" "3.875" "1" "1" "1" "1" "1259" "142.1" "6.04" "3.31" "1" "cell organization and biogenesis;transport" "cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf12584" "7109" "ENSG00000160218" "TRAPPC10" "hsa:7109; P48553; Q3MIR2; Q86SI7; Q9UMD4; Q9Y4L3" "" "RAB GEFs exchange GTP for GDP on RABs; COPII-mediated vesicle transport" "2" "0" "1.147" "1.015" "0.882" "1.023" "0.847" "1.030" "0.916" "1.073" "1.069" "80.1" "91.9" "81.4" "70.7" "82.0" "67.9" "82.5" "73.4" "86.0" "85.7" "" "" "" "" "" "" "" "" "" "" "72.1" "74.4" "73.6" "69.0" "67.7" "67.9" "61.8" "64.9" "76.9" "30.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4546155412470536460" "False" "High" "IsMasterProtein" "Q9NQS7" "Inner centromere protein OS=Homo sapiens OX=9606 GN=INCENP PE=1 SV=3" "0.002" "False" "3.873" "2" "1" "1" "1" "918" "105.4" "9.44" "3.96" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf03941, Pf12178" "3619" "ENSG00000149503" "INCENP" "A8MQD2; hsa:3619; Q5Y192; Q9NQS7" "" "SUMOylation of DNA replication proteins; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "738970082796446266" "False" "High" "IsMasterProtein" "Q8N5M9" "Protein jagunal homolog 1 OS=Homo sapiens OX=9606 GN=JAGN1 PE=1 SV=1" "0.002" "False" "3.873" "7" "1" "1" "1" "183" "21.1" "9.73" "4.82" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi" "" "Pf07086" "84522" "ENSG00000171135" "JAGN1" "hsa:84522; Q8N5M9; Q8NCF6; Q96SW1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-100464243051471028" "False" "High" "IsMasterProtein" "Q9H063" "Repressor of RNA polymerase III transcription MAF1 homolog OS=Homo sapiens OX=9606 GN=MAF1 PE=1 SV=2" "0.002" "False" "3.871" "5" "1" "1" "1" "256" "28.8" "4.55" "3.15" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09174" "84232" "ENSG00000179632" "MAF1" "D3DWL4; hsa:84232; Q9H063" "" "Regulation of PTEN gene transcription" "1" "0" "0.969" "0.920" "0.787" "1.050" "0.901" "1.107" "0.824" "0.770" "3.323" "112.9" "109.4" "103.9" "88.8" "118.5" "101.6" "124.9" "93.0" "86.9" "375.0" "" "" "" "" "" "" "" "" "" "" "101.5" "88.5" "94.0" "86.7" "97.8" "101.6" "93.5" "82.2" "77.8" "133.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7225862634974144158" "False" "High" "IsMasterProtein" "Q8N392" "Rho GTPase-activating protein 18 OS=Homo sapiens OX=9606 GN=ARHGAP18 PE=1 SV=3" "0.002" "False" "3.869" "2" "1" "1" "1" "663" "74.9" "6.44" "3.25" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity" "Pf00620" "93663" "ENSG00000146376" "ARHGAP18" "E1P575; hsa:93663; Q58EZ3; Q6P679; Q6PJD7; Q8N392; Q96S64" "" "RHOC GTPase cycle; RHOA GTPase cycle" "2" "0" "0.920" "1.037" "0.982" "1.196" "0.953" "1.000" "0.995" "0.688" "0.775" "30.5" "28.1" "31.6" "29.9" "36.5" "29.1" "30.5" "30.3" "21.0" "23.6" "" "" "" "" "" "" "" "" "" "" "27.4" "22.7" "28.6" "29.2" "30.1" "29.1" "22.8" "26.8" "18.8" "8.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8281195296370466031" "False" "High" "IsMasterProtein" "P0CG13" "Chromosome transmission fidelity protein 8 homolog OS=Homo sapiens OX=9606 GN=CHTF8 PE=1 SV=1" "0.002" "False" "3.867" "11" "1" "2" "1" "121" "13.3" "8.18" "4.28" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "Pf09696" "54921" "ENSG00000168802" "CHTF8" "A8MYX8; hsa:54921; P0CG13; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "Gastric cancer network 2" "Polymerase switching on the C-strand of the telomere" "2" "0" "0.992" "0.960" "1.030" "0.930" "1.101" "0.975" "1.022" "0.998" "1.918" "98.2" "97.5" "94.3" "101.2" "91.4" "108.2" "95.7" "100.4" "98.0" "188.4" "" "" "" "" "" "" "" "" "" "" "88.3" "78.9" "85.3" "98.8" "75.4" "108.2" "71.7" "88.7" "87.7" "67.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1768771022967141070" "False" "High" "IsMasterProtein" "Q9Y4H4" "G-protein-signaling modulator 3 OS=Homo sapiens OX=9606 GN=GPSM3 PE=1 SV=1" "0.002" "False" "3.863" "14" "1" "1" "1" "160" "17.9" "4.97" "4.74" "1" "other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "Pf02188" "63940" "ENSG00000206314; ENSG00000213654; ENSG00000233490; ENSG00000234243; ENSG00000234508; ENSG00000236697; ENSG00000237052" "GPSM3" "A2BFJ3; hsa:63940; Q9Y4H4" "" "G alpha (i) signalling events" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3585506896184313716" "False" "High" "IsMasterProtein" "P63218" "Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 OS=Homo sapiens OX=9606 GN=GNG5 PE=1 SV=3" "0.002" "False" "3.861" "13" "1" "2" "1" "68" "7.3" "9.85" "7.26" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00631" "2787" "ENSG00000174021" "GNG5" "B2R5A0; hsa:2787; P30670; P63218; Q5VX54; Q61015" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Calcium regulation in cardiac cells; Pathways in cancer" "Ca2+ pathway; G alpha (12/13) signalling events; G alpha (q) signalling events; G alpha (i) signalling events; G alpha (z) signalling events; ADP signalling through P2Y purinoceptor 12; G alpha (s) signalling events; Extra-nuclear estrogen signaling; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Thrombin signalling through proteinase activated receptors (PARs); Activation of G protein gated Potassium channels; G-protein activation; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; G beta:gamma signalling through PI3Kgamma; Prostacyclin signalling through prostacyclin receptor; Adrenaline,noradrenaline inhibits insulin secretion; G beta:gamma signalling through PLC beta; ADP signalling through P2Y purinoceptor 1; Glucagon-type ligand receptors; Thromboxane signalling through TP receptor; Vasopressin regulates renal water homeostasis via Aquaporins; Presynaptic function of Kainate receptors; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding; G beta:gamma signalling through BTK; G beta:gamma signalling through CDC42; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits; Glucagon signaling in metabolic regulation" "36" "0" "0.854" "0.930" "0.871" "0.909" "0.995" "0.932" "0.925" "1.124" "0.728" "140.2" "119.7" "130.4" "122.1" "127.4" "139.5" "130.6" "129.7" "157.6" "102.1" "" "" "" "" "" "" "" "" "" "" "126.1" "96.8" "118.0" "119.2" "105.1" "139.5" "97.8" "114.5" "141.0" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7513240538999229112" "False" "High" "IsMasterProtein" "O95136" "Sphingosine 1-phosphate receptor 2 OS=Homo sapiens OX=9606 GN=S1PR2 PE=1 SV=2" "0.002" "False" "3.859" "3" "1" "1" "1" "353" "38.8" "8.97" "3.14" "1" "cell-cell signaling;cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00001" "9294" "ENSG00000267534" "S1PR2" "hsa:9294; O95136; Q86UN8" "Small ligand GPCRs; S1P receptor signal transduction; Sphingolipid metabolism in senescence" "G alpha (i) signalling events; Lysosphingolipid and LPA receptors" "5" "0" "0.782" "0.952" "0.936" "0.925" "0.771" "0.876" "1.060" "0.893" "0.559" "35.2" "27.5" "33.5" "33.0" "32.5" "27.1" "30.8" "37.3" "31.4" "19.7" "" "" "" "" "" "" "" "" "" "" "31.6" "22.3" "30.3" "32.2" "26.9" "27.1" "23.1" "32.9" "28.1" "7.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5930476095621651501" "False" "High" "IsMasterProtein" "Q15283" "Ras GTPase-activating protein 2 OS=Homo sapiens OX=9606 GN=RASA2 PE=1 SV=3" "0.002" "False" "3.856" "1" "1" "1" "1" "850" "96.6" "7.20" "3.51" "1" "signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00168, Pf00169, Pf00616, Pf00779" "5922" "ENSG00000155903" "RASA2" "A8K7K1; G3V0F9; hsa:5922; O00695; Q15283; Q15284; Q92594; Q99577; Q9UEQ2" "MAPK signaling pathway; Ebola virus infection in host; Ras signaling; Modulators of TCR signaling and T cell activation" "Regulation of RAS by GAPs" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8351496581142553779" "False" "High" "IsMasterProtein" "Q12986" "Transcriptional repressor NF-X1 OS=Homo sapiens OX=9606 GN=NFX1 PE=1 SV=2" "0.002" "False" "3.856" "1" "1" "1" "1" "1120" "124.3" "8.24" "3.71" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01422, Pf01424" "4799" "ENSG00000086102" "NFX1" "A8K6H8; hsa:4799; Q12986; Q5VXW6; Q96EL5; Q9BXI1" "Fas ligand pathway and stress induction of heat shock proteins" "" "1" "0" "0.948" "1.025" "0.717" "0.932" "1.217" "0.927" "0.953" "0.813" "0.912" "46.1" "43.7" "47.3" "33.1" "43.0" "56.2" "42.8" "44.0" "37.5" "42.1" "" "" "" "" "" "" "" "" "" "" "41.5" "35.4" "42.8" "32.3" "35.5" "56.2" "32.0" "38.9" "33.6" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5641519450922138293" "False" "High" "IsMasterProtein" "P15954" "Cytochrome c oxidase subunit 7C, mitochondrial OS=Homo sapiens OX=9606 GN=COX7C PE=1 SV=1" "0.002" "False" "3.856" "14" "1" "2" "1" "63" "7.2" "10.27" "6.81" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02935" "1350" "ENSG00000127184" "COX7C" "hsa:1350; P15954; Q6NR81" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "7" "0" "0.920" "0.932" "0.920" "0.894" "1.012" "1.032" "1.025" "1.014" "0.508" "104.4" "96.1" "97.3" "96.0" "93.3" "105.6" "107.8" "107.0" "105.8" "53.0" "" "" "" "" "" "" "" "" "" "" "93.9" "77.7" "88.0" "93.8" "77.0" "105.6" "80.7" "94.5" "94.7" "18.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5303653638395268189" "False" "High" "IsMasterProtein" "Q16633" "POU domain class 2-associating factor 1 OS=Homo sapiens OX=9606 GN=POU2AF1 PE=1 SV=1" "0.002" "False" "3.854" "4" "1" "1" "1" "256" "27.4" "4.94" "3.76" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf09310" "5450" "ENSG00000110777" "POU2AF1" "B2R8Z9; hsa:5450; Q14983; Q16633" "" "" "0" "0" "0.834" "0.710" "0.898" "0.923" "0.795" "0.939" "0.937" "0.828" "0.830" "210.0" "175.0" "149.1" "188.6" "193.8" "166.9" "197.1" "196.7" "173.9" "174.4" "" "" "" "" "" "" "" "" "" "" "188.8" "141.6" "134.8" "184.1" "159.9" "166.9" "147.6" "173.7" "155.6" "62.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4624493070796375817" "False" "High" "IsMasterProtein" "Q7Z7H8" "Large ribosomal subunit protein uL10m OS=Homo sapiens OX=9606 GN=MRPL10 PE=1 SV=3" "0.002" "False" "3.853" "4" "1" "1" "1" "261" "29.3" "9.58" "4.19" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00466" "124995" "ENSG00000159111" "MRPL10" "A6NGJ4; hsa:124995; Q7Z7H8; Q96B80; Q96Q55" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "0.952" "1.037" "0.972" "1.020" "0.946" "1.046" "1.004" "1.052" "1.321" "181.1" "172.4" "187.8" "176.0" "184.6" "171.3" "189.4" "181.9" "190.4" "239.2" "" "" "" "" "" "" "" "" "" "" "162.8" "139.5" "169.9" "171.8" "152.4" "171.3" "141.8" "160.6" "170.4" "85.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4884717818161655002" "False" "High" "IsMasterProtein" "Q9H4L5" "Oxysterol-binding protein-related protein 3 OS=Homo sapiens OX=9606 GN=OSBPL3 PE=1 SV=1" "0.002" "False" "3.850" "1" "1" "1" "1" "887" "101.2" "6.87" "4.77" "1" "other metabolic processes;transport" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf01237, Pf15409" "26031" "ENSG00000070882" "OSBPL3" "A4D167; A4D168; A4D169; A4D170; A4D171; A4D172; B8ZZ79; B8ZZP0; hsa:26031; O14591; O43357; O43358; Q8N702; Q8N703; Q8N704; Q8NFH0; Q8NFH1; Q8NI12; Q8NI13; Q9BZF4; Q9H4L5; Q9UED6" "Orexin receptor pathway" "Synthesis of bile acids and bile salts" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1794648964700596183" "False" "High" "IsMasterProtein" "Q00013" "55 kDa erythrocyte membrane protein OS=Homo sapiens OX=9606 GN=MPP1 PE=1 SV=2" "0.002" "False" "3.849" "3" "1" "1" "1" "466" "52.3" "7.37" "2.49" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;kinase activity" "Pf00018, Pf00595, Pf00625" "4354" "ENSG00000130830" "MPP1" "B4DZV5; G3XAI1; hsa:4354; Q00013; Q2TSB6; Q5J7V5" "MECP2 and associated Rett syndrome" "Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.207" "1.053" "0.921" "0.841" "0.899" "0.978" "0.931" "0.907" "1.007" "34.5" "41.6" "36.3" "31.8" "29.0" "31.0" "33.7" "32.1" "31.3" "34.7" "" "" "" "" "" "" "" "" "" "" "31.0" "33.7" "32.8" "31.0" "23.9" "31.0" "25.2" "28.4" "28.0" "12.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2116736278876107348" "False" "High" "IsMasterProtein" "Q8IW45" "ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Homo sapiens OX=9606 GN=NAXD PE=1 SV=1" "0.002" "False" "3.849" "5" "2" "2" "2" "347" "36.6" "8.06" "5.54" "2" "other metabolic processes" "mitochondrion" "other molecular function" "Pf01256" "55739" "ENSG00000213995" "NAXD" "B4DXT4; hsa:55739; Q5T9X3; Q8IW45; Q9H7W1; Q9NVF5" "" "Nicotinamide salvaging" "1" "0" "0.963" "1.126" "0.933" "1.052" "1.018" "0.866" "0.902" "0.970" "0.930" "216.3" "208.3" "243.6" "201.8" "227.5" "220.3" "187.4" "195.2" "209.8" "201.1" "" "" "" "" "" "" "" "" "" "" "194.5" "168.5" "220.3" "197.0" "187.7" "220.3" "140.3" "172.4" "187.7" "71.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3711449830735196489" "False" "High" "IsMasterProtein" "Q9BZJ0" "Crooked neck-like protein 1 OS=Homo sapiens OX=9606 GN=CRNKL1 PE=1 SV=4" "0.002" "False" "3.848" "2" "1" "1" "1" "848" "100.4" "8.00" "2.64" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf02184" "51340" "ENSG00000101343" "CRNKL1" "A8K9T4; hsa:51340; Q5JY64; Q8WYI5; Q9BZI9; Q9BZJ0; Q9BZJ1; Q9BZJ2; Q9GZW7; Q9H8F8; Q9NQH5; Q9NYD8" "" "mRNA Splicing - Major Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2523415922773781630" "False" "High" "IsMasterProtein" "Q9Y3C1" "Nucleolar protein 16 OS=Homo sapiens OX=9606 GN=NOP16 PE=1 SV=2" "0.002" "False" "3.847" "10" "2" "2" "2" "178" "21.2" "9.94" "4.77" "2" "other biological processes" "nucleus;other cell component" "" "Pf09420" "51491" "ENSG00000048162" "NOP16" "B4DV13; D6RGD3; hsa:51491; Q05D05; Q6IAI6; Q6PIM0; Q8IXL5; Q9Y3C1" "5q35 copy number variation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5050264383982318884" "False" "High" "IsMasterProtein" "Q9NV79" "Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PCMTD2 PE=1 SV=2" "0.002" "False" "3.844" "4" "2" "2" "2" "361" "41.0" "6.11" "2.75" "2" "protein metabolism;other metabolic processes" "other cell component" "other molecular function" "Pf01135" "55251" "ENSG00000203880; ENSG00000280663" "PCMTD2" "E1P5H3; hsa:55251; Q8IW60; Q9H4K2; Q9NV79" "" "" "0" "0" "0.996" "1.034" "0.888" "0.928" "1.151" "0.917" "0.992" "0.992" "1.022" "199.5" "198.8" "206.2" "177.1" "185.2" "229.7" "183.0" "197.8" "197.9" "203.8" "" "" "" "" "" "" "" "" "" "" "179.4" "160.8" "186.5" "172.9" "152.8" "229.7" "137.0" "174.7" "177.1" "72.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1618235937448484575" "False" "High" "IsMasterProtein" "P04839" "Cytochrome b-245 heavy chain OS=Homo sapiens OX=9606 GN=CYBB PE=1 SV=2" "0.002" "False" "3.844" "2" "1" "1" "1" "570" "65.3" "8.63" "3.57" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01794, Pf08022, Pf08030" "1536" "ENSG00000165168" "CYBB" "A8K138; hsa:1536; P04839; Q2PP16" "Alzheimer's disease and miRNA effects; VEGFA-VEGFR2 signaling; Microglia pathogen phagocytosis pathway; Oxidative stress response; Ferroptosis; Alzheimer's disease; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease; HDAC6 interactions in the central nervous system; Type II interferon signaling" "RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Neutrophil degranulation; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "19" "0" "0.919" "0.857" "0.828" "0.893" "0.980" "0.776" "1.027" "1.127" "0.716" "20.5" "18.8" "17.5" "16.9" "18.3" "20.1" "15.9" "21.0" "23.1" "14.6" "" "" "" "" "" "" "" "" "" "" "18.4" "15.2" "15.9" "16.5" "15.1" "20.1" "11.9" "18.5" "20.6" "5.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2699158399968223668" "False" "High" "IsMasterProtein" "Q15311" "RalA-binding protein 1 OS=Homo sapiens OX=9606 GN=RALBP1 PE=1 SV=3" "0.002" "False" "3.844" "3" "2" "2" "2" "655" "76.0" "5.88" "4.90" "2" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;nucleus" "transporter activity;enzyme regulator activity;other molecular function" "Pf00620, Pf20924" "10928" "ENSG00000017797" "RALBP1" "D3DUI0; hsa:10928; Q15311" "RalA downstream regulated genes; Ras signaling; Pancreatic adenocarcinoma pathway; EGF/EGFR signaling pathway" "CDC42 GTPase cycle; RAC1 GTPase cycle" "6" "0" "1.031" "1.087" "0.758" "0.839" "0.857" "1.039" "0.974" "1.007" "1.189" "55.9" "57.6" "60.7" "42.3" "46.9" "47.9" "58.0" "54.4" "56.3" "66.4" "" "" "" "" "" "" "" "" "" "" "50.2" "46.6" "54.9" "41.3" "38.7" "47.9" "43.5" "48.1" "50.4" "23.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5693736025540312441" "False" "High" "IsMasterProtein" "P0CG12" "Decreased expression in renal and prostate cancer protein OS=Homo sapiens OX=9606 GN=DERPC PE=1 SV=1" "0.002" "False" "3.842" "3" "1" "1" "1" "524" "51.4" "12.41" "4.49" "1" "" "nucleus" "" "" "" "ENSG00000286140" "DERPC" "A8MYX8; P0CG12; Q71E72; Q8NDH8; Q8WV66; Q9NX73" "" "" "0" "0" "1.390" "1.099" "1.081" "1.356" "1.164" "1.182" "1.394" "1.084" "1.171" "73.9" "102.7" "81.2" "79.8" "100.1" "86.0" "87.3" "103.0" "80.0" "86.5" "" "" "" "" "" "" "" "" "" "" "66.4" "83.1" "73.4" "77.9" "82.6" "86.0" "65.4" "90.9" "71.6" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3550614013973356196" "False" "High" "IsMasterProtein" "Q9GZX9" "Twisted gastrulation protein homolog 1 OS=Homo sapiens OX=9606 GN=TWSG1 PE=1 SV=1" "0.002" "False" "3.835" "4" "1" "1" "1" "223" "25.0" "5.34" "3.27" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular" "other molecular function" "Pf04668" "57045" "ENSG00000128791" "TWSG1" "B2RE08; D3DUH9; hsa:57045; Q8NBI7; Q96K46; Q9GZX9" "Mesodermal commitment pathway; Mesodermal commitment pathway" "" "2" "0" "1.104" "1.439" "1.001" "1.138" "1.471" "1.028" "0.937" "1.203" "1.038" "76.7" "84.7" "110.3" "76.8" "87.3" "112.8" "78.9" "71.9" "92.2" "79.6" "" "" "" "" "" "" "" "" "" "" "69.0" "68.5" "99.8" "75.0" "72.0" "112.8" "59.1" "63.5" "82.5" "28.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3724111757375065163" "False" "High" "IsMasterProtein" "Q9P0W2" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related OS=Homo sapiens OX=9606 GN=HMG20B PE=1 SV=1" "0.002" "False" "3.834" "3" "1" "2" "1" "317" "35.8" "9.35" "3.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00505" "10362" "ENSG00000064961" "HMG20B" "A6NMS5; D6W616; hsa:10362; Q6IBP8; Q8NBD5; Q9HD21; Q9P0W2; Q9Y491; Q9Y4A2" "" "Factors involved in megakaryocyte development and platelet production; Potential therapeutics for SARS; HDACs deacetylate histones" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4969818127362219692" "False" "High" "IsMasterProtein" "Q9H0R1" "AP-5 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP5M1 PE=1 SV=2" "0.002" "False" "3.834" "3" "2" "2" "2" "490" "54.7" "6.61" "5.13" "2" "transport" "other membranes;cytosol;other cytoplasmic organelle" "" "Pf00928" "55745" "ENSG00000053770" "AP5M1" "hsa:55745; O95354; Q6ZMD7; Q96DX3; Q9H0R1; Q9NVC5" "" "" "0" "0" "1.327" "0.994" "0.969" "1.123" "1.025" "1.244" "0.944" "1.220" "1.665" "97.0" "128.8" "96.4" "94.1" "109.0" "99.4" "120.7" "91.6" "118.3" "161.5" "" "" "" "" "" "" "" "" "" "" "87.2" "104.2" "87.2" "91.8" "90.0" "99.4" "90.4" "80.9" "105.9" "57.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "340635961720124479" "False" "High" "IsMasterProtein" "O75140" "GATOR1 complex protein DEPDC5 OS=Homo sapiens OX=9606 GN=DEPDC5 PE=1 SV=2" "0.002" "False" "3.831" "1" "1" "1" "1" "1603" "181.1" "6.73" "4.05" "1" "stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf00610, Pf12257, Pf19418" "9681" "ENSG00000100150" "DEPDC5" "A6H8V6; A8MPX9; B4DH93; B9EGN9; hsa:9681; O75140; Q5K3V5; Q5THY9; Q5THZ0; Q5THZ1; Q5THZ3; Q68DR1; Q6MZX3; Q6PEZ1; Q9UGV8; Q9UH13" "22q11.2 copy number variation syndrome" "Amino acids regulate mTORC1" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2168737288158195697" "False" "High" "IsMasterProtein" "Q9Y2K1" "Zinc finger and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZBTB1 PE=1 SV=3" "0.002" "False" "3.831" "2" "1" "2" "1" "713" "82.0" "6.39" "7.06" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "22890" "ENSG00000126804" "ZBTB1" "A8K6S8; hsa:22890; Q86SW8; Q9Y2K1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "Not Found" "High" "High" "High" "High" "Not Found" "1" "" "6041079011054164235" "False" "High" "IsMasterProtein" "Q9NYA4" "Myotubularin-related protein 4 OS=Homo sapiens OX=9606 GN=MTMR4 PE=1 SV=2" "0.002" "False" "3.827" "1" "1" "1" "1" "1195" "133.3" "6.04" "3.74" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf06602" "9110" "ENSG00000108389" "MTMR4" "D3DTZ6; hsa:9110; Q8IV27; Q9NYA4; Q9Y4D5" "" "Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Downregulation of TGF-beta receptor signaling" "3" "0" "0.878" "1.000" "0.901" "1.041" "1.089" "1.041" "1.157" "1.060" "0.972" "71.5" "62.8" "71.5" "64.4" "74.4" "77.9" "74.4" "82.7" "75.8" "69.5" "" "" "" "" "" "" "" "" "" "" "64.3" "50.8" "64.7" "62.9" "61.4" "77.9" "55.7" "73.0" "67.8" "24.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4094952149974440381" "False" "High" "IsMasterProtein" "Q9H3P2" "Negative elongation factor A OS=Homo sapiens OX=9606 GN=NELFA PE=1 SV=3" "0.002" "False" "3.827" "2" "1" "1" "1" "528" "57.2" "9.03" "3.84" "1" "other biological processes" "cytosol;nucleus" "other molecular function" "" "7469" "ENSG00000185049" "NELFA" "A2A2T1; hsa:7469; O95392; Q9H3P2" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "RNA Polymerase II Pre-transcription Events; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.126" "1.015" "0.916" "0.974" "1.030" "1.122" "0.949" "0.871" "6.886" "146.8" "165.3" "149.1" "134.5" "143.0" "151.2" "164.8" "139.3" "127.9" "1010.7" "" "" "" "" "" "" "" "" "" "" "132.0" "133.8" "134.8" "131.3" "118.0" "151.2" "123.4" "123.0" "114.4" "360.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7972887412222597887" "False" "High" "IsMasterProtein" "Q9UIS9" "Methyl-CpG-binding domain protein 1 OS=Homo sapiens OX=9606 GN=MBD1 PE=1 SV=2" "0.003" "False" "3.820" "2" "1" "1" "1" "605" "66.6" "9.04" "3.01" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01429, Pf02008" "4152" "ENSG00000141644" "MBD1" "A4UTZ0; B4DXJ5; E9PEC5; hsa:4152; K7ELI2; K7EQZ4; K7ESN0; O15248; O95241; Q7Z7B5; Q8N4W4; Q9UIS9; Q9UNZ6; Q9UNZ7; Q9UNZ8; Q9UNZ9" "Sudden infant death syndrome (SIDS) susceptibility pathways" "SUMOylation of transcription cofactors" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2478117011496918927" "False" "High" "IsMasterProtein" "Q13206" "Probable ATP-dependent RNA helicase DDX10 OS=Homo sapiens OX=9606 GN=DDX10 PE=1 SV=2" "0.002" "False" "3.816" "2" "1" "1" "1" "875" "100.8" "8.63" "3.33" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00270, Pf00271, Pf13959" "1662" "ENSG00000178105" "DDX10" "B2RCQ3; hsa:1662; Q13206; Q5BJD8" "" "" "0" "0" "1.018" "1.006" "0.950" "0.922" "1.028" "0.895" "1.009" "0.917" "1.086" "65.9" "67.1" "66.3" "62.6" "60.8" "67.7" "59.0" "66.5" "60.4" "71.6" "" "" "" "" "" "" "" "" "" "" "59.2" "54.3" "59.9" "61.1" "50.2" "67.7" "44.1" "58.7" "54.1" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "918212557622448470" "False" "High" "IsMasterProtein" "Q9HAJ7" "Histone deacetylase complex subunit SAP30L OS=Homo sapiens OX=9606 GN=SAP30L PE=1 SV=1" "0.002" "False" "3.814" "5" "1" "1" "1" "183" "20.9" "9.36" "2.89" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "79685" "ENSG00000164576" "SAP30L" "E9PAU7; E9PAY2; hsa:79685; Q9HAJ7" "" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "3" "0" "0.862" "0.926" "0.822" "0.922" "0.912" "0.940" "0.919" "0.824" "1.294" "141.2" "121.8" "130.7" "116.1" "130.3" "128.8" "132.8" "129.8" "116.4" "182.7" "" "" "" "" "" "" "" "" "" "" "127.0" "98.5" "118.2" "113.3" "107.5" "128.8" "99.4" "114.7" "104.1" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5795480292757374636" "False" "High" "IsMasterProtein" "Q6PJ61" "F-box only protein 46 OS=Homo sapiens OX=9606 GN=FBXO46 PE=1 SV=3" "0.002" "False" "3.808" "2" "1" "1" "1" "603" "64.6" "7.40" "4.21" "1" "" "" "" "Pf12937" "23403" "ENSG00000177051" "FBXO46" "hsa:23403; Q6PJ61" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-104196132274101736" "False" "High" "IsMasterProtein" "Q9GZT4" "Serine racemase OS=Homo sapiens OX=9606 GN=SRR PE=1 SV=1" "0.002" "False" "3.805" "4" "1" "1" "1" "340" "36.5" "6.54" "4.71" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00291" "63826" "ENSG00000167720" "SRR" "D3DTI5; hsa:63826; Q6IA55; Q9GZT4" "Neuroinflammation and glutamatergic signaling" "Serine biosynthesis" "2" "0" "1.219" "0.939" "1.078" "1.128" "1.330" "1.154" "1.066" "1.070" "0.847" "89.5" "109.2" "84.1" "96.5" "101.0" "119.1" "103.3" "95.5" "95.8" "75.9" "" "" "" "" "" "" "" "" "" "" "80.5" "88.4" "76.0" "94.2" "83.4" "119.1" "77.4" "84.3" "85.7" "27.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9090626993025068401" "False" "High" "IsMasterProtein" "O75386" "Tubby-related protein 3 OS=Homo sapiens OX=9606 GN=TULP3 PE=1 SV=2" "0.002" "False" "3.804" "3" "1" "1" "1" "442" "49.6" "7.74" "3.34" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01167, Pf16322" "7289" "ENSG00000078246" "TULP3" "B3KNB7; B7Z6A2; D3DUQ4; F8WBZ9; hsa:7289; O75386; Q8N5B0" "H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity; Genes related to primary cilium development (based on CRISPR)" "Hedgehog 'off' state" "3" "0" "1.083" "1.506" "1.184" "1.206" "1.335" "1.020" "1.204" "1.248" "1.484" "31.2" "33.8" "47.0" "37.0" "37.6" "41.7" "31.8" "37.6" "38.9" "46.3" "" "" "" "" "" "" "" "" "" "" "28.1" "27.4" "42.5" "36.1" "31.1" "41.7" "23.8" "33.2" "34.8" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "271678290460553006" "False" "High" "IsMasterProtein" "P43307" "Translocon-associated protein subunit alpha OS=Homo sapiens OX=9606 GN=SSR1 PE=1 SV=3" "0.002" "False" "3.803" "5" "1" "1" "1" "286" "32.2" "4.49" "0.00" "1" "other biological processes" "other membranes;ER/Golgi" "" "Pf03896" "6745" "ENSG00000124783" "SSR1" "A8K685; hsa:6745; P43307; Q53GX2; Q53H19; Q5TAM3; Q6IB43; Q8NBH9; Q96IA2; Q9TNQ8; Q9UN49" "" "SRP-dependent cotranslational protein targeting to membrane; XBP1(S) activates chaperone genes" "2" "0" "1.070" "1.111" "1.021" "1.202" "1.032" "0.990" "1.076" "1.137" "0.968" "79.8" "85.4" "88.7" "81.5" "95.9" "82.3" "79.0" "85.9" "90.7" "77.2" "" "" "" "" "" "" "" "" "" "" "71.7" "69.1" "80.2" "79.5" "79.1" "82.3" "59.1" "75.8" "81.2" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "242013550511196324" "False" "High" "IsMasterProtein" "Q6IQ19" "Centriole, cilia and spindle-associated protein OS=Homo sapiens OX=9606 GN=CCSAP PE=1 SV=2" "0.002" "False" "3.797" "4" "1" "1" "1" "270" "30.2" "7.84" "3.25" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf15748" "126731" "ENSG00000154429" "CCSAP" "A8K5X2; hsa:126731; Q6IQ19; Q6P9G2; Q6ZW85; Q8IXU1; Q96BM2" "" "" "0" "0" "1.093" "1.216" "1.054" "1.212" "1.251" "1.244" "1.057" "1.224" "1.056" "107.2" "117.2" "130.4" "112.9" "130.0" "134.1" "133.3" "113.3" "131.2" "113.2" "" "" "" "" "" "" "" "" "" "" "96.4" "94.8" "117.9" "110.2" "107.2" "134.1" "99.8" "100.1" "117.4" "40.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5489281537849050427" "False" "High" "IsMasterProtein" "Q9UEU0" "Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens OX=9606 GN=VTI1B PE=1 SV=3" "0.002" "False" "3.795" "5" "1" "1" "1" "232" "26.7" "9.04" "3.66" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "non-structural extracellular;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05008, Pf12352" "10490" "ENSG00000100568" "VTI1B" "hsa:10490; O43547; Q96J28; Q9UEU0" "" "Platelet degranulation" "1" "0" "0.864" "1.077" "0.872" "0.804" "0.999" "0.756" "0.929" "0.862" "1.164" "54.0" "46.6" "58.1" "47.1" "43.4" "53.9" "40.8" "50.1" "46.5" "62.8" "" "" "" "" "" "" "" "" "" "" "48.5" "37.7" "52.6" "45.9" "35.8" "53.9" "30.5" "44.3" "41.6" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1316883428224227619" "False" "High" "IsMasterProtein" "Q8WYQ5" "Microprocessor complex subunit DGCR8 OS=Homo sapiens OX=9606 GN=DGCR8 PE=1 SV=1" "0.002" "False" "3.789" "1" "1" "2" "1" "773" "86.0" "5.95" "2.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00035" "54487" "ENSG00000128191" "DGCR8" "B2R8G1; hsa:54487; Q6DCB2; Q6MZE9; Q6Y2L0; Q8WYQ5; Q96G39; Q96GP8; Q9H6L8; Q9H6T7; Q9NRW2" "miRNA biogenesis; exRNA mechanism of action and biogenesis; DDX1 as a regulatory component of the Drosha microprocessor; 22q11.2 copy number variation syndrome" "Transcriptional Regulation by MECP2; MicroRNA (miRNA) biogenesis" "6" "0" "0.999" "1.037" "0.994" "1.209" "0.980" "1.063" "0.981" "1.103" "0.918" "189.3" "189.1" "196.4" "188.1" "228.9" "185.6" "201.3" "185.7" "208.8" "173.8" "" "" "" "" "" "" "" "" "" "" "170.2" "153.0" "177.6" "183.6" "188.9" "185.6" "150.7" "164.1" "186.8" "62.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3143696315815793188" "False" "High" "IsMasterProtein" "Q8WXH0" "Nesprin-2 OS=Homo sapiens OX=9606 GN=SYNE2 PE=1 SV=3" "0.002" "False" "3.788" "0" "2" "2" "2" "6885" "795.9" "5.36" "2.13" "2" "cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf00435, Pf10541" "23224" "ENSG00000054654" "SYNE2" "B4DND7; B4DPR6; I6XXQ5; Q540G1; Q86YP9; Q8N1S3; Q8NF49; Q8TER7; Q8WWW3; Q8WWW4; Q8WWW5; Q8WXH0; Q8WXH1; Q9NU50; Q9UFQ4; Q9Y2L4; Q9Y4R1" "Ovarian infertility; Rett syndrome; Envelope proteins and their potential roles in EDMD physiopathology" "Meiotic synapsis" "4" "0" "0.951" "1.451" "1.015" "1.228" "0.962" "1.216" "0.810" "1.216" "5.437" "18.8" "17.9" "27.3" "19.1" "23.1" "18.1" "22.8" "15.2" "22.8" "102.2" "" "" "" "" "" "" "" "" "" "" "16.9" "14.5" "24.7" "18.6" "19.1" "18.1" "17.1" "13.4" "20.4" "36.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7572022130176331113" "False" "High" "IsMasterProtein" "Q9H840" "Gem-associated protein 7 OS=Homo sapiens OX=9606 GN=GEMIN7 PE=1 SV=1" "0.002" "False" "3.782" "21" "1" "1" "1" "131" "14.5" "7.40" "5.83" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf11095" "79760" "ENSG00000142252" "GEMIN7" "hsa:79760; Q6IA34; Q9H840" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.046" "0.840" "1.014" "0.869" "0.649" "0.938" "1.031" "1.001" "0.729" "22.0" "23.0" "18.4" "22.3" "19.1" "14.3" "20.6" "22.7" "22.0" "16.0" "" "" "" "" "" "" "" "" "" "" "19.8" "18.6" "16.7" "21.7" "15.7" "14.3" "15.4" "20.0" "19.7" "5.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2774592991242960215" "False" "High" "IsMasterProtein" "Q9H0H0" "Integrator complex subunit 2 OS=Homo sapiens OX=9606 GN=INTS2 PE=1 SV=2" "0.002" "False" "3.782" "1" "2" "2" "2" "1204" "134.2" "6.05" "5.58" "2" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;nucleus;other cell component" "" "Pf14750" "57508" "ENSG00000108506" "INTS2" "hsa:57508; Q9H0H0; Q9ULD3" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5882151393090730100" "False" "High" "IsMasterProtein" "Q8TA86" "Retinitis pigmentosa 9 protein OS=Homo sapiens OX=9606 GN=RP9 PE=1 SV=2" "0.002" "False" "3.777" "4" "1" "3" "1" "221" "26.1" "9.79" "8.23" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;ER/Golgi;nucleus" "other molecular function" "" "6100" "ENSG00000164610" "RP9" "hsa:6100; Q8TA86" "" "" "0" "0" "0.951" "0.881" "0.848" "0.891" "0.980" "0.941" "0.872" "0.774" "0.631" "169.4" "161.1" "149.3" "143.6" "150.8" "165.9" "159.4" "147.7" "131.2" "106.8" "" "" "" "" "" "" "" "" "" "" "152.3" "130.3" "135.0" "140.2" "124.5" "165.9" "119.3" "130.4" "117.4" "38.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8108900187098047619" "False" "High" "IsMasterProtein" "Q9H6U6" "BCAS3 microtubule associated cell migration factor OS=Homo sapiens OX=9606 GN=BCAS3 PE=1 SV=3" "0.002" "False" "3.777" "2" "1" "1" "1" "928" "101.2" "6.70" "3.82" "1" "cell-cell signaling;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf12490, Pf21034" "54828" "ENSG00000141376" "BCAS3" "hsa:54828; Q17RM0; Q6KF21; Q8IXI6; Q8NDR8; Q8TDL9; Q8TDM1; Q8WY55; Q9BVF0; Q9H6U6; Q9H957; Q9H9Y9; Q9NXP4" "Ectoderm differentiation" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2670423242739876361" "False" "High" "IsMasterProtein" "Q14146" "Unhealthy ribosome biogenesis protein 2 homolog OS=Homo sapiens OX=9606 GN=URB2 PE=1 SV=2" "0.002" "False" "3.771" "1" "2" "2" "2" "1524" "170.4" "7.31" "4.60" "2" "other biological processes" "nucleus;other cell component" "" "Pf10441" "9816" "ENSG00000135763" "URB2" "hsa:9816; Q14146; Q5VYC9" "" "" "0" "0" "0.946" "0.847" "0.670" "0.901" "1.087" "0.591" "0.658" "0.658" "0.515" "41.6" "39.3" "35.2" "27.9" "37.5" "45.2" "24.6" "27.4" "27.4" "21.4" "" "" "" "" "" "" "" "" "" "" "37.4" "31.8" "31.8" "27.2" "30.9" "45.2" "18.4" "24.2" "24.5" "7.6" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1235212219621904744" "False" "High" "IsMasterProtein" "Q8IY92" "Structure-specific endonuclease subunit SLX4 OS=Homo sapiens OX=9606 GN=SLX4 PE=1 SV=3" "0.003" "False" "3.756" "1" "1" "1" "1" "1834" "199.9" "6.06" "3.03" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00651, Pf09494" "84464" "ENSG00000188827" "SLX4" "hsa:84464; Q69YT8; Q8IY92; Q8TF15; Q96JP1" "Nucleotide excision repair in xeroderma pigmentosum" "Resolution of D-loop Structures through Holliday Junction Intermediates; Fanconi Anemia Pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7044477500846696439" "False" "High" "IsMasterProtein" "Q96DP5" "Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens OX=9606 GN=MTFMT PE=1 SV=2" "0.003" "False" "3.756" "3" "1" "1" "1" "389" "43.8" "9.66" "3.41" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf00551, Pf02911" "123263" "ENSG00000103707" "MTFMT" "B7Z734; hsa:123263; Q96DP5" "One-carbon metabolism" "Mitochondrial translation initiation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3706590846700109807" "False" "High" "IsMasterProtein" "Q9ULF5" "Zinc transporter ZIP10 OS=Homo sapiens OX=9606 GN=SLC39A10 PE=1 SV=2" "0.003" "False" "3.755" "2" "1" "1" "1" "831" "94.1" "6.76" "4.53" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf02535" "57181" "ENSG00000196950" "SLC39A10" "A8K5C6; B4DGU0; hsa:57181; Q3MJA4; Q68CR5; Q6DKH6; Q9ULF5; Q9Y3Z1" "Nuclear receptors meta-pathway; NRF2 pathway; Zinc homeostasis" "Zinc influx into cells by the SLC39 gene family" "4" "0" "1.057" "1.087" "0.975" "1.008" "1.080" "0.918" "1.164" "0.867" "0.762" "86.4" "91.4" "93.9" "84.2" "87.1" "93.3" "79.3" "100.5" "74.9" "65.8" "" "" "" "" "" "" "" "" "" "" "77.7" "73.9" "84.9" "82.2" "71.9" "93.3" "59.4" "88.8" "67.1" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6115091388662522029" "False" "High" "IsMasterProtein" "P55211" "Caspase-9 OS=Homo sapiens OX=9606 GN=CASP9 PE=1 SV=3" "0.003" "False" "3.744" "2" "1" "1" "1" "416" "46.3" "6.05" "3.58" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf00656" "842" "ENSG00000132906" "CASP9" "B4E1A3; hsa:842; O95348; P55211; Q53Y70; Q5JRU9; Q5UGI1; Q92852; Q9BQ62; Q9UEQ3; Q9UIJ8" "Nucleotide-binding oligomerization domain (NOD) pathway; miRNA regulation of DNA damage response; Alzheimer's disease and miRNA effects; TNF-alpha signaling pathway; AGE/RAGE pathway; Allograft rejection; Corticotropin-releasing hormone signaling pathway; Parkinson's disease pathway; Amyotrophic lateral sclerosis (ALS); Nanomaterial induced apoptosis; Apoptosis; Fas ligand pathway and stress induction of heat shock proteins; RAC1/PAK1/p38/MMP2 pathway; Hepatitis C and hepatocellular carcinoma; Apoptosis modulation by HSP70; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; miRNA regulation of p53 pathway in prostate cancer; NO/cGMP/PKG mediated neuroprotection; Endometrial cancer; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Non-small cell lung cancer; Pancreatic adenocarcinoma pathway; MTHFR deficiency; Acute viral myocarditis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Thyroid hormones production and peripheral downstream signaling effects; Regucalcin in proximal tubule epithelial kidney cells; Host-pathogen interaction of human coronaviruses - apoptosis; Complement system in neuronal development and plasticity; Alzheimer's disease; Urotensin-II-mediated signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; DNA damage response" "Constitutive Signaling by AKT1 E17K in Cancer; Activation of caspases through apoptosome-mediated cleavage; SMAC (DIABLO) binds to IAPs ; SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ; Regulation of the apoptosome activity; NOD1/2 Signaling Pathway; AKT phosphorylates targets in the cytosol; Caspase activation via Dependence Receptors in the absence of ligand" "47" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3230263422708412736" "False" "High" "IsMasterProtein" "Q6UWP8" "Suprabasin OS=Homo sapiens OX=9606 GN=SBSN PE=1 SV=2" "0.003" "False" "3.740" "6" "1" "1" "1" "590" "60.5" "7.01" "3.07" "1" "" "" "" "Pf21009" "374897" "ENSG00000189001" "SBSN" "A8K5J0; E9PBV3; hsa:374897; Q6UWP8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3876786205952927758" "False" "High" "IsMasterProtein" "Q5BKU9" "Oxidoreductase-like domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OXLD1 PE=1 SV=1" "0.003" "False" "3.727" "10" "1" "1" "1" "147" "15.8" "8.22" "2.26" "1" "" "" "" "Pf09791" "339229" "ENSG00000204237" "OXLD1" "A6ND24; hsa:339229; Q5BKU9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2707692795518285071" "False" "High" "IsMasterProtein" "Q567U6" "Coiled-coil domain-containing protein 93 OS=Homo sapiens OX=9606 GN=CCDC93 PE=1 SV=2" "0.003" "False" "3.727" "2" "1" "1" "1" "631" "73.2" "8.15" "3.54" "1" "transport" "other cytoplasmic organelle;other cell component" "" "Pf09762, Pf21673" "54520" "ENSG00000125633" "CCDC93" "A8K3V7; hsa:54520; Q4LE78; Q53TJ2; Q567U6; Q8TBX5; Q9H6R5; Q9NV15" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2147212707680779052" "False" "High" "IsMasterProtein" "P49427" "Ubiquitin-conjugating enzyme E2 R1 OS=Homo sapiens OX=9606 GN=CDC34 PE=1 SV=2" "0.003" "False" "3.722" "6" "2" "2" "1" "236" "26.7" "4.54" "5.53" "2" "cell cycle OR cell proliferation;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00179" "997" "ENSG00000099804" "CDC34" "A8K689; hsa:997; P49427" "Vitamin D receptor pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; Antigen processing: Ubiquitination & Proteasome degradation; CLEC7A (Dectin-1) signaling" "6" "0" "1.078" "1.337" "1.061" "1.318" "1.243" "1.086" "1.108" "1.266" "3.538" "176.6" "190.3" "236.1" "187.3" "232.7" "219.4" "191.7" "195.7" "223.5" "624.6" "" "" "" "" "" "" "" "" "" "" "158.8" "154.0" "213.5" "182.8" "192.1" "219.4" "143.6" "172.9" "200.0" "223.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3235762539968315400" "False" "High" "IsMasterProtein" "Q8WTV0" "Scavenger receptor class B member 1 OS=Homo sapiens OX=9606 GN=SCARB1 PE=1 SV=1" "0.003" "False" "3.721" "2" "1" "1" "1" "552" "60.8" "8.24" "3.71" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01130" "949" "ENSG00000073060" "SCARB1" "F8W8N0; hsa:949; Q14016; Q52LZ5; Q6KFX4; Q8WTV0" "Selenium micronutrient network; Vitamin B12 metabolism; Folate metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Statin inhibition of cholesterol production; SARS-CoV-2 and COVID-19 pathway; Familial hyperlipidemia type 3; Cholesterol metabolism; Vitamin A and carotenoid metabolism" "" "9" "0" "0.924" "0.865" "0.929" "0.943" "0.822" "1.024" "0.883" "0.956" "0.735" "138.8" "128.3" "120.1" "128.9" "130.9" "114.1" "142.1" "122.6" "132.7" "102.1" "" "" "" "" "" "" "" "" "" "" "124.8" "103.8" "108.6" "125.9" "108.0" "114.1" "106.4" "108.3" "118.8" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1143885462092768664" "False" "High" "IsMasterProtein" "Q8N2K0" "Lysophosphatidylserine lipase ABHD12 OS=Homo sapiens OX=9606 GN=ABHD12 PE=1 SV=2" "0.003" "False" "3.716" "3" "1" "1" "1" "398" "45.1" "8.65" "4.95" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00561" "26090" "ENSG00000100997" "ABHD12" "A6NED4; A6NJ90; A8K450; B4DE71; hsa:26090; Q5T710; Q5T711; Q8N2K0; Q96CR1; Q9BX05; Q9NPX7; Q9UFV6" "" "Arachidonate production from DAG" "1" "0" "1.136" "0.932" "1.159" "0.951" "1.006" "1.094" "1.252" "1.038" "0.801" "23.9" "27.1" "22.3" "27.7" "22.7" "24.1" "26.1" "29.9" "24.8" "19.1" "" "" "" "" "" "" "" "" "" "" "21.5" "22.0" "20.1" "27.0" "18.8" "24.1" "19.6" "26.4" "22.2" "6.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "126204850056993689" "False" "High" "IsMasterProtein" "Q9NPB8" "Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens OX=9606 GN=GPCPD1 PE=1 SV=2" "0.003" "False" "3.716" "2" "1" "1" "1" "672" "76.0" "5.53" "4.47" "1" "other metabolic processes;other biological processes" "cytosol" "other molecular function" "Pf00686, Pf03009" "56261" "ENSG00000125772" "GPCPD1" "D3DW06; hsa:56261; Q9BQL8; Q9NPB8; Q9NUX0" "" "Hydrolysis of LPC; Hydrolysis of LPE" "2" "0" "0.828" "0.947" "0.781" "0.955" "0.999" "1.105" "1.048" "0.708" "1.186" "34.8" "28.8" "33.0" "27.2" "33.3" "34.8" "38.5" "36.5" "24.7" "41.3" "" "" "" "" "" "" "" "" "" "" "31.3" "23.3" "29.9" "26.5" "27.4" "34.8" "28.8" "32.3" "22.1" "14.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2486972886246464504" "False" "High" "IsMasterProtein" "O00221" "NF-kappa-B inhibitor epsilon OS=Homo sapiens OX=9606 GN=NFKBIE PE=1 SV=3" "0.003" "False" "3.709" "2" "1" "1" "1" "500" "52.8" "6.68" "4.28" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf00023" "4794" "ENSG00000146232" "NFKBIE" "hsa:4794; O00221; Q5T9V9" "TNF-alpha signaling pathway; Apoptosis; Oxidative damage response; Canonical NF-kB pathway; IL-18 signaling pathway; STING pathway in Kawasaki-like disease and COVID-19" "Activation of NF-kappaB in B cells" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6108263305464485910" "False" "High" "IsMasterProtein" "O95644" "Nuclear factor of activated T-cells, cytoplasmic 1 OS=Homo sapiens OX=9606 GN=NFATC1 PE=1 SV=3" "0.003" "False" "3.706" "2" "2" "2" "1" "943" "101.2" "6.99" "5.41" "2" "stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00554, Pf16179" "4772" "ENSG00000131196" "NFATC1" "B5B2M4; B5B2M5; B5B2M6; B5B2M7; B5B2M8; B5B2M9; B5B2N1; hsa:4772; O95644; Q12865; Q15793; Q2M1S3" "Heart development; RANKL/RANK signaling pathway; Ectoderm differentiation; Initiation of transcription and translation elongation at the HIV-1 LTR; MAPK signaling pathway; VEGFA-VEGFR2 signaling; Wnt signaling; Vitamin D in inflammatory diseases; Cancer immunotherapy by PD-1 blockade; Hepatitis B infection; Th17 cell differentiation pathway; DYRK1A involvement regarding cell proliferation in brain development; Inflammatory bowel disease signaling; Clock-controlled autophagy in bone metabolism; IL-26 signaling pathways; T-cell receptor signaling pathway" "FCERI mediated Ca+2 mobilization; Ca2+ pathway; CLEC7A (Dectin-1) induces NFAT activation; Calcineurin activates NFAT" "20" "0" "1.154" "1.019" "0.799" "0.971" "1.030" "1.121" "0.977" "0.984" "1.737" "58.1" "67.0" "59.2" "46.4" "56.4" "59.8" "65.2" "56.8" "57.2" "100.9" "" "" "" "" "" "" "" "" "" "" "52.2" "54.2" "53.5" "45.3" "46.6" "59.8" "48.8" "50.1" "51.2" "36.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3308081350103847019" "False" "High" "IsMasterProtein" "P61218" "DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Homo sapiens OX=9606 GN=POLR2F PE=1 SV=1" "0.003" "False" "3.705" "12" "2" "2" "2" "127" "14.5" "4.22" "5.17" "2" "RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01192" "5435" "ENSG00000100142" "POLR2F" "hsa:5435; P41584; P61218; Q6IAY3" "Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "mRNA Splicing - Major Pathway; FGFR2 alternative splicing; Processing of Capped Intron-Containing Pre-mRNA; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; Activation of anterior HOX genes in hindbrain development during early embryogenesis; Estrogen-dependent gene expression; RNA Polymerase I Promoter Escape; Inhibition of DNA recombination at telomere; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; mRNA Splicing - Minor Pathway; Signaling by FGFR2 IIIa TM" "56" "0" "1.271" "1.374" "1.043" "1.201" "1.610" "1.288" "1.417" "1.133" "1.194" "204.6" "259.9" "281.1" "213.4" "245.8" "329.5" "263.5" "289.8" "231.8" "244.2" "" "" "" "" "" "" "" "" "" "" "183.9" "210.3" "254.2" "208.3" "202.8" "329.5" "197.3" "256.0" "207.4" "87.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1870630596764229112" "False" "High" "IsMasterProtein" "Q15643" "Thyroid receptor-interacting protein 11 OS=Homo sapiens OX=9606 GN=TRIP11 PE=1 SV=3" "0.003" "False" "3.705" "1" "1" "1" "1" "1979" "227.4" "5.26" "3.79" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytoskeleton;ER/Golgi" "other molecular function" "" "9321" "ENSG00000100815" "TRIP11" "B2RUT2; hsa:9321; O14689; O15154; O95949; Q15643; Q6MZL5" "" "Intraflagellar transport; Intra-Golgi traffic; Signaling by FLT3 fusion proteins" "3" "0" "0.927" "1.074" "0.961" "1.088" "1.096" "0.994" "1.014" "1.313" "2.166" "58.3" "54.0" "62.6" "56.0" "63.4" "63.9" "57.9" "59.1" "76.5" "126.2" "" "" "" "" "" "" "" "" "" "" "52.4" "43.7" "56.6" "54.6" "52.3" "63.9" "43.4" "52.2" "68.5" "45.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8109670193418590883" "False" "High" "IsMasterProtein" "O14641" "Segment polarity protein dishevelled homolog DVL-2 OS=Homo sapiens OX=9606 GN=DVL2 PE=1 SV=1" "0.003" "False" "3.704" "2" "1" "1" "1" "736" "78.9" "6.02" "3.51" "1" "cell-cell signaling;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00595, Pf00610, Pf00778, Pf02377, Pf12316" "1856" "ENSG00000004975" "DVL2" "D3DTN3; hsa:1856; O14641; Q53XM0" "Alzheimer's disease and miRNA effects; Neural crest differentiation; Notch signaling; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Embryonic stem cell pluripotency pathways; Wnt signaling pathway and pluripotency; Wnt signaling in kidney disease; Type 2 papillary renal cell carcinoma; lncRNA in canonical Wnt signaling and colorectal cancer; Breast cancer pathway; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma; Alzheimer's disease; DNA damage response (only ATM dependent)" "RHO GTPases Activate Formins; Asymmetric localization of PCP proteins; Degradation of DVL; Cargo recognition for clathrin-mediated endocytosis; WNT mediated activation of DVL; Disassembly of the destruction complex and recruitment of AXIN to the membrane; Negative regulation of TCF-dependent signaling by DVL-interacting proteins; WNT5:FZD7-mediated leishmania damping; Signaling by Hippo; WNT5A-dependent internalization of FZD4" "29" "0" "1.459" "1.259" "1.046" "0.809" "1.409" "0.992" "1.048" "1.293" "5.065" "26.2" "38.3" "33.0" "27.4" "21.2" "37.0" "26.0" "27.5" "33.9" "132.9" "" "" "" "" "" "" "" "" "" "" "23.6" "31.0" "29.9" "26.8" "17.5" "37.0" "19.5" "24.3" "30.4" "47.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4002844298631346291" "False" "High" "IsMasterProtein" "Q53H47" "Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens OX=9606 GN=SETMAR PE=1 SV=2" "0.003" "False" "3.700" "1" "1" "1" "1" "684" "78.0" "7.14" "3.70" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00856, Pf01359, Pf05033, Pf17906" "6419" "ENSG00000170364" "SETMAR" "B4DY74; E7EN68; hsa:6419; Q13579; Q1G668; Q53H47; Q96F41" "Histone modifications" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2370626703481031957" "False" "High" "IsMasterProtein" "Q9H7N4" "Splicing factor, arginine/serine-rich 19 OS=Homo sapiens OX=9606 GN=SCAF1 PE=1 SV=3" "0.003" "False" "3.695" "1" "1" "1" "1" "1312" "139.2" "9.25" "3.49" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "" "58506" "ENSG00000126461" "SCAF1" "hsa:58506; Q7Z5V7; Q8WVA1; Q9H7N4; Q9NR59" "" "" "0" "0" "1.097" "1.117" "1.051" "1.026" "1.206" "0.917" "1.009" "1.020" "1.384" "34.5" "37.8" "38.6" "36.3" "35.4" "41.6" "31.7" "34.8" "35.2" "47.8" "" "" "" "" "" "" "" "" "" "" "31.0" "30.6" "34.9" "35.4" "29.2" "41.6" "23.7" "30.7" "31.5" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "649692950129023278" "False" "High" "IsMasterProtein" "Q96QF0" "Rab-3A-interacting protein OS=Homo sapiens OX=9606 GN=RAB3IP PE=1 SV=1" "0.003" "False" "3.692" "4" "2" "2" "2" "476" "53.0" "5.97" "5.16" "2" "cell organization and biogenesis;transport;other biological processes" "cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf06428" "117177" "ENSG00000127328" "RAB3IP" "B7WPJ6; hsa:117177; Q6PCE4; Q96A24; Q96QE6; Q96QE7; Q96QE8; Q96QE9; Q96QF0; Q96QF1; Q9H673" "Joubert syndrome" "Anchoring of the basal body to the plasma membrane; RAB GEFs exchange GTP for GDP on RABs; BBSome-mediated cargo-targeting to cilium; VxPx cargo-targeting to cilium" "5" "0" "0.949" "1.142" "0.614" "1.035" "0.841" "1.069" "1.108" "0.652" "0.836" "124.0" "117.6" "141.6" "76.1" "128.4" "104.3" "132.5" "137.4" "80.8" "103.6" "" "" "" "" "" "" "" "" "" "" "111.5" "95.2" "128.1" "74.3" "105.9" "104.3" "99.2" "121.3" "72.3" "37.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8013178931392780313" "False" "High" "IsMasterProtein" "Q9H6V9" "Lipid droplet-associated hydrolase OS=Homo sapiens OX=9606 GN=LDAH PE=1 SV=1" "0.003" "False" "3.691" "4" "2" "2" "2" "325" "37.3" "6.54" "5.24" "2" "other metabolic processes;other biological processes" "ER/Golgi;other cell component" "other molecular function" "Pf10230" "60526" "ENSG00000118961" "LDAH" "B7ZA47; B7ZAJ5; D6W530; E7ESN0; hsa:60526; Q53T37; Q53T58; Q9H6V9" "" "" "0" "0" "1.128" "1.006" "1.162" "1.185" "1.003" "0.997" "1.068" "1.110" "1.179" "150.9" "170.2" "151.9" "175.4" "178.9" "151.4" "150.4" "161.2" "167.6" "178.0" "" "" "" "" "" "" "" "" "" "" "135.7" "137.7" "137.4" "171.2" "147.6" "151.4" "112.6" "142.4" "149.9" "63.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2735298958942986864" "False" "High" "IsMasterProtein" "Q9Y5F7" "Protocadherin gamma-C4 OS=Homo sapiens OX=9606 GN=PCDHGC4 PE=1 SV=1" "0.003" "False" "3.688" "3" "2" "2" "1" "938" "101.2" "5.35" "0.00" "2" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56098" "ENSG00000242419" "PCDHGC4" "hsa:56098; Q495T2; Q9Y5C3; Q9Y5F7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2613446227669289232" "False" "High" "IsMasterProtein" "Q9H8K7" "ATPase PAAT OS=Homo sapiens OX=9606 GN=PAAT PE=1 SV=2" "0.003" "False" "3.682" "2" "1" "1" "1" "445" "49.2" "6.25" "3.52" "1" "" "mitochondrion;other cell component" "other molecular function" "Pf14958" "80007" "ENSG00000119965" "PAAT" "hsa:80007; Q0P6C6; Q8N597; Q9H8K7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2492385812914646204" "False" "High" "IsMasterProtein" "O14730" "Serine/threonine-protein kinase RIO3 OS=Homo sapiens OX=9606 GN=RIOK3 PE=1 SV=2" "0.003" "False" "3.679" "3" "2" "2" "2" "519" "59.1" "5.76" "0.00" "2" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf01163" "8780" "ENSG00000101782" "RIOK3" "O14730; Q8IXN9" "Hematopoietic stem cell differentiation" "Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-387642789641095952" "False" "High" "IsMasterProtein" "Q9HAU4" "E3 ubiquitin-protein ligase SMURF2 OS=Homo sapiens OX=9606 GN=SMURF2 PE=1 SV=1" "0.003" "False" "3.675" "2" "1" "1" "1" "748" "86.1" "7.96" "2.84" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00168, Pf00397, Pf00632" "64750" "ENSG00000108854" "SMURF2" "hsa:64750; Q52LL1; Q9H260; Q9HAU4" "TGF-beta signaling pathway; Hedgehog signaling pathway" "Ub-specific processing proteases; Antigen processing: Ubiquitination & Proteasome degradation; Asymmetric localization of PCP proteins; Degradation of AXIN; Hedgehog 'on' state; Regulation of RUNX3 expression and activity; Signaling by BMP; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "Not Found" "Not Found" "High" "High" "High" "High" "High" "High" "1" "" "-995658337958950277" "False" "High" "IsMasterProtein" "Q9HB09" "Bcl-2-like protein 12 OS=Homo sapiens OX=9606 GN=BCL2L12 PE=1 SV=2" "0.003" "False" "3.674" "6" "1" "1" "1" "250" "26.9" "5.72" "3.83" "1" "other biological processes" "" "other molecular function" "" "" "ENSG00000126453" "BCL2L12" "A0A087WSV0" "Regulation of apoptosis by parathyroid hormone-related protein" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8770420070751581353" "False" "High" "IsMasterProtein" "Q16718" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Homo sapiens OX=9606 GN=NDUFA5 PE=1 SV=3" "0.003" "False" "3.673" "8" "1" "1" "1" "116" "13.5" "5.99" "3.47" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf04716" "4698" "ENSG00000128609" "NDUFA5" "B2RD98; hsa:4698; Q16718; Q5H9R2; Q6IRX7" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "RHOG GTPase cycle; Complex I biogenesis" "7" "0" "1.015" "1.284" "1.278" "1.206" "1.302" "1.234" "1.152" "1.356" "1.515" "194.1" "196.9" "249.2" "247.9" "234.0" "252.7" "239.4" "223.5" "263.1" "294.0" "" "" "" "" "" "" "" "" "" "" "174.5" "159.4" "225.4" "242.0" "193.1" "252.7" "179.3" "197.4" "235.4" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7933868971006090466" "False" "High" "IsMasterProtein" "Q8WUH2" "Transforming growth factor-beta receptor-associated protein 1 OS=Homo sapiens OX=9606 GN=TGFBRAP1 PE=1 SV=1" "0.003" "False" "3.666" "1" "1" "1" "1" "860" "97.1" "6.55" "3.76" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00637, Pf00780, Pf10366, Pf10367" "9392" "ENSG00000135966" "TGFBRAP1" "A8K5R7; D3DVJ8; hsa:9392; O60466; Q8WUH2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2083530276327625921" "False" "High" "IsMasterProtein" "Q9BUW7" "Bublin coiled-coil protein OS=Homo sapiens OX=9606 GN=BBLN PE=1 SV=1" "0.003" "False" "3.665" "19" "1" "1" "1" "83" "9.0" "4.22" "3.76" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "Pf03670" "79095" "ENSG00000171159" "BBLN" "hsa:79095; Q5SYV8; Q9BUW7; Q9Y3F7" "" "" "0" "0" "0.835" "1.050" "0.764" "1.201" "1.271" "0.955" "0.862" "1.041" "0.953" "37.3" "31.2" "39.2" "28.5" "44.9" "47.5" "35.7" "32.2" "38.9" "35.6" "" "" "" "" "" "" "" "" "" "" "33.6" "25.2" "35.5" "27.9" "37.0" "47.5" "26.7" "28.4" "34.8" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-763212604296308746" "False" "High" "IsMasterProtein" "Q8IXH7" "Negative elongation factor C/D OS=Homo sapiens OX=9606 GN=NELFCD PE=1 SV=2" "0.003" "False" "3.654" "2" "1" "1" "1" "590" "66.2" "5.10" "3.87" "1" "other biological processes" "nucleus" "nucleic acid binding activity" "Pf04858" "51497" "ENSG00000101158" "NELFCD" "B4DE06; hsa:51497; Q8IXH7; Q9BYL2; Q9H405; Q9H888; Q9H8T3; Q9NVX5; Q9P029; Q9UGN1; Q9UGN2; Q9UGN3" "Initiation of transcription and translation elongation at the HIV-1 LTR; 4p16.3 copy number variation" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes" "16" "0" "1.079" "0.973" "0.783" "1.062" "0.935" "0.984" "0.797" "0.929" "5.024" "137.3" "148.0" "133.6" "107.5" "145.8" "128.3" "135.0" "109.4" "127.6" "689.6" "" "" "" "" "" "" "" "" "" "" "123.4" "119.8" "120.9" "104.9" "120.4" "128.3" "101.1" "96.6" "114.2" "246.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4281858283280689015" "False" "High" "IsMasterProtein" "Q53GS7" "mRNA export factor GLE1 OS=Homo sapiens OX=9606 GN=GLE1 PE=1 SV=2" "0.003" "False" "3.649" "3" "1" "1" "1" "698" "79.8" "7.43" "3.33" "1" "other metabolic processes;transport" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf07817" "2733" "ENSG00000119392" "GLE1" "hsa:2733; O75458; Q53GS7; Q53GT9; Q5VVU1; Q8NCP6; Q9UFL6" "" "Transport of Mature mRNA derived from an Intron-Containing Transcript" "1" "0" "1.088" "1.235" "0.819" "1.033" "0.743" "0.893" "0.954" "0.937" "1.199" "27.7" "30.1" "34.1" "22.6" "28.6" "20.6" "24.7" "26.4" "25.9" "33.2" "" "" "" "" "" "" "" "" "" "" "24.9" "24.4" "30.9" "22.1" "23.6" "20.6" "18.5" "23.3" "23.2" "11.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8414928618058390258" "False" "High" "IsMasterProtein" "Q8N9N2" "Activating signal cointegrator 1 complex subunit 1 OS=Homo sapiens OX=9606 GN=ASCC1 PE=1 SV=1" "0.003" "False" "3.649" "2" "1" "1" "1" "400" "45.5" "5.54" "3.47" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf00013, Pf10469" "51008" "ENSG00000138303" "ASCC1" "hsa:51008; Q5SW06; Q5SW07; Q8N9N2; Q96EI8; Q9Y307" "Neuroinflammation" "ALKBH3 mediated reversal of alkylation damage" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6748145975597498784" "False" "High" "IsMasterProtein" "O75920" "Small EDRK-rich factor 1 OS=Homo sapiens OX=9606 GN=SERF1B PE=1 SV=1" "0.003" "False" "3.649" "8" "1" "1" "1" "110" "12.3" "9.76" "3.80" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04419" "728492; 8293" "ENSG00000172058; ENSG00000205572; ENSG00000275581; ENSG00000277429; ENSG00000278839" "SERF1A; SERF1B" "B7ZKM2; hsa:728492; hsa:8293; O75919; O75920; Q52LK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7234885358333908901" "False" "High" "IsMasterProtein" "O75915" "PRA1 family protein 3 OS=Homo sapiens OX=9606 GN=ARL6IP5 PE=1 SV=1" "0.003" "False" "3.647" "6" "1" "2" "1" "188" "21.6" "9.77" "7.33" "1" "other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi" "" "Pf03208" "10550" "ENSG00000144746" "ARL6IP5" "B2R6V5; hsa:10550; O75915; Q53ES3; Q5KU08" "" "Glutamate Neurotransmitter Release Cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2535135395164112803" "False" "High" "IsMasterProtein" "Q96KM6" "Zinc finger protein 512B OS=Homo sapiens OX=9606 GN=ZNF512B PE=1 SV=1" "0.003" "False" "3.641" "1" "1" "1" "1" "892" "97.2" "9.83" "3.74" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf21276" "57473" "ENSG00000196700" "ZNF512B" "hsa:57473; Q08AK9; Q96KM6; Q9ULM4" "" "RHOV GTPase cycle" "1" "0" "0.957" "1.125" "0.972" "0.909" "1.123" "0.830" "1.026" "1.088" "0.709" "70.5" "67.5" "79.3" "68.5" "64.1" "79.2" "58.5" "72.3" "76.7" "50.0" "" "" "" "" "" "" "" "" "" "" "63.4" "54.6" "71.7" "66.9" "52.9" "79.2" "43.8" "63.9" "68.6" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5936229442522610236" "False" "High" "IsMasterProtein" "Q9H204" "Mediator of RNA polymerase II transcription subunit 28 OS=Homo sapiens OX=9606 GN=MED28 PE=1 SV=1" "0.003" "False" "3.634" "5" "1" "1" "1" "178" "19.5" "5.58" "4.08" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytoskeleton;nucleus" "cytoskeletal activity" "Pf11594" "80306" "ENSG00000118579" "MED28" "hsa:80306; Q9BZJ5; Q9H204" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "1.043" "0.977" "0.994" "0.993" "0.993" "1.006" "0.976" "0.984" "0.884" "261.3" "272.5" "255.3" "259.8" "259.6" "259.4" "263.0" "255.1" "257.3" "231.1" "" "" "" "" "" "" "" "" "" "" "235.0" "220.5" "230.9" "253.6" "214.2" "259.4" "196.9" "225.3" "230.2" "82.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-585008616192458607" "False" "High" "IsMasterProtein" "Q9H6E5" "Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Homo sapiens OX=9606 GN=TUT1 PE=1 SV=2" "0.003" "False" "3.631" "2" "1" "1" "1" "874" "93.8" "6.16" "3.31" "1" "RNA metabolism OR transcription;other metabolic processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076, Pf03828, Pf12874" "64852" "ENSG00000149016" "TUT1" "A1A527; A8K995; hsa:64852; Q2NL65; Q7L583; Q9H6E5; Q9H6H7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8270070607048707079" "False" "High" "IsMasterProtein" "Q7Z7N9" "Transmembrane protein 179B OS=Homo sapiens OX=9606 GN=TMEM179B PE=1 SV=1" "0.003" "False" "3.627" "7" "1" "1" "1" "219" "23.5" "7.85" "3.37" "1" "" "plasma membrane;other membranes;nucleus;other cytoplasmic organelle" "" "" "374395" "ENSG00000185475" "TMEM179B" "hsa:374395; Q7Z7N9" "" "Neutrophil degranulation" "1" "0" "0.945" "0.886" "1.013" "1.047" "1.146" "0.872" "0.891" "0.961" "0.822" "43.4" "41.0" "38.4" "43.9" "45.4" "49.7" "37.8" "38.6" "41.7" "35.7" "" "" "" "" "" "" "" "" "" "" "39.0" "33.2" "34.8" "42.9" "37.5" "49.7" "28.3" "34.1" "37.3" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1865855424515257827" "False" "High" "IsMasterProtein" "Q9H0F6" "Sharpin OS=Homo sapiens OX=9606 GN=SHARPIN PE=1 SV=1" "0.003" "False" "3.620" "4" "1" "1" "1" "387" "39.9" "5.80" "2.65" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "other molecular function" "Pf16764" "81858" "ENSG00000179526" "SHARPIN" "A6NEG3; C0L3L2; D3DWL3; hsa:81858; Q8IXF5; Q8IXF6; Q8N2E7; Q8TB25; Q9BUE4; Q9H0F6" "" "Neurexins and neuroligins; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; TNFR1-induced proapoptotic signaling" "4" "0" "0.823" "0.648" "0.827" "0.838" "0.719" "0.970" "0.996" "0.719" "0.544" "35.5" "29.2" "23.0" "29.4" "29.8" "25.5" "34.5" "35.4" "25.6" "19.3" "" "" "" "" "" "" "" "" "" "" "31.9" "23.7" "20.8" "28.7" "24.6" "25.5" "25.8" "31.2" "22.9" "6.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4697558618654746564" "False" "High" "IsMasterProtein" "Q92546" "RAB6A-GEF complex partner protein 2 OS=Homo sapiens OX=9606 GN=RGP1 PE=1 SV=1" "0.003" "False" "3.617" "3" "1" "1" "1" "391" "42.4" "5.96" "3.70" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "enzyme regulator activity;other molecular function" "Pf08737" "9827" "ENSG00000107185" "RGP1" "hsa:9827; Q5TCV5; Q92546" "" "RAB GEFs exchange GTP for GDP on RABs; Retrograde transport at the Trans-Golgi-Network; Intra-Golgi traffic" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4804252067301605975" "False" "High" "IsMasterProtein" "Q5SW96" "Low density lipoprotein receptor adapter protein 1 OS=Homo sapiens OX=9606 GN=LDLRAP1 PE=1 SV=3" "0.003" "False" "3.617" "4" "1" "1" "1" "308" "33.9" "6.70" "3.32" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00640" "26119" "ENSG00000157978" "LDLRAP1" "A2BHI5; hsa:26119; Q5SW96; Q6TQS9; Q8N2Y0; Q9UFI9" "Familial hyperlipidemia type 2; Cholesterol metabolism; Fatty acids and lipoproteins transport in hepatocytes" "Cargo recognition for clathrin-mediated endocytosis; Transport of RCbl within the body; LDL clearance; Vitamin D (calciferol) metabolism; Chylomicron clearance" "9" "0" "1.042" "1.017" "0.960" "0.916" "1.045" "1.071" "0.965" "1.133" "2.247" "41.6" "43.3" "42.3" "40.0" "38.1" "43.5" "44.6" "40.2" "47.1" "93.5" "" "" "" "" "" "" "" "" "" "" "37.4" "35.1" "38.3" "39.0" "31.4" "43.5" "33.4" "35.5" "42.2" "33.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2520392851407789687" "False" "High" "IsMasterProtein" "O00401" "Actin nucleation-promoting factor WASL OS=Homo sapiens OX=9606 GN=WASL PE=1 SV=2" "0.003" "False" "3.603" "3" "2" "2" "2" "505" "54.8" "7.93" "4.97" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;cytoskeletal activity" "Pf00568, Pf00786, Pf02205" "8976" "ENSG00000106299" "WASL" "A1JUI9; hsa:8976; O00401; Q7Z746" "Pathogenic Escherichia coli infection; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Chemokine signaling pathway; G13 signaling pathway" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHO GTPases Activate WASPs and WAVEs; RHOJ GTPase cycle; RHOV GTPase cycle; Clathrin-mediated endocytosis; NOSTRIN mediated eNOS trafficking; Nephrin family interactions; EPHB-mediated forward signaling; DCC mediated attractive signaling" "17" "0" "0.969" "0.919" "0.703" "0.925" "0.920" "0.991" "0.848" "0.849" "0.842" "138.2" "133.8" "127.0" "97.2" "127.9" "127.2" "137.0" "117.2" "117.4" "116.4" "" "" "" "" "" "" "" "" "" "" "124.2" "108.3" "114.9" "94.8" "105.5" "127.2" "102.6" "103.5" "105.0" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2817610694198924296" "False" "High" "IsMasterProtein" "P62841" "Small ribosomal subunit protein uS19 OS=Homo sapiens OX=9606 GN=RPS15 PE=1 SV=2" "0.003" "False" "3.597" "8" "1" "1" "1" "145" "17.0" "10.39" "3.64" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00203" "6209" "ENSG00000115268" "RPS15" "A5D8V9; hsa:6209; P11174; P62841; Q3KRA1; Q9UDC2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "0.937" "0.998" "0.985" "0.852" "0.969" "0.852" "0.862" "1.015" "1.407" "201.7" "189.0" "201.4" "198.7" "171.8" "195.4" "171.8" "173.8" "204.7" "283.7" "" "" "" "" "" "" "" "" "" "" "181.3" "152.9" "182.1" "194.0" "141.8" "195.4" "128.7" "153.5" "183.1" "101.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-507311622488501760" "False" "High" "IsMasterProtein" "Q9Y2G5" "GDP-fucose protein O-fucosyltransferase 2 OS=Homo sapiens OX=9606 GN=POFUT2 PE=1 SV=3" "0.003" "False" "3.596" "3" "1" "1" "1" "429" "49.9" "6.60" "4.74" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf10250" "23275" "ENSG00000186866" "POFUT2" "hsa:23275; Q6PJV1; Q7Z4N0; Q8WWU6; Q9BQS4; Q9BQS5; Q9UFY3; Q9Y2G5" "" "O-glycosylation of TSR domain-containing proteins" "1" "0" "1.094" "1.055" "1.076" "1.107" "1.178" "0.988" "1.029" "1.245" "0.959" "136.2" "148.9" "143.7" "146.6" "150.8" "160.4" "134.6" "140.1" "169.6" "130.6" "" "" "" "" "" "" "" "" "" "" "122.4" "120.5" "130.0" "143.1" "124.4" "160.4" "100.8" "123.7" "151.7" "46.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5448753331326211859" "False" "High" "IsMasterProtein" "Q9NX38" "Protein Abitram OS=Homo sapiens OX=9606 GN=ABITRAM PE=1 SV=1" "0.003" "False" "3.590" "6" "1" "1" "1" "181" "20.4" "7.93" "3.47" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "cytoskeletal activity" "Pf01597" "54942" "ENSG00000119328" "ABITRAM" "hsa:54942; Q5JTR0; Q5JTR1; Q9NX38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-789511479774361380" "False" "High" "IsMasterProtein" "Q14202" "Zinc finger MYM-type protein 3 OS=Homo sapiens OX=9606 GN=ZMYM3 PE=1 SV=2" "0.003" "False" "3.584" "1" "2" "2" "2" "1370" "152.3" "6.35" "2.69" "2" "cell organization and biogenesis;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06467, Pf12012" "9203" "ENSG00000147130" "ZMYM3" "D3DVV3; hsa:9203; O15089; Q14202; Q96E26" "Orexin receptor pathway" "" "1" "0" "1.023" "1.008" "0.912" "0.867" "1.031" "1.060" "1.018" "1.004" "2.152" "116.6" "119.3" "117.5" "106.3" "101.1" "120.2" "123.7" "118.7" "117.1" "250.9" "" "" "" "" "" "" "" "" "" "" "104.8" "96.5" "106.3" "103.8" "83.4" "120.2" "92.6" "104.9" "104.7" "89.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6622425969869744688" "False" "High" "IsMasterProtein" "Q9H4M3" "F-box only protein 44 OS=Homo sapiens OX=9606 GN=FBXO44 PE=1 SV=3" "0.003" "False" "3.583" "6" "1" "1" "1" "255" "29.7" "5.82" "3.44" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "" "Pf04300, Pf12937" "93611" "ENSG00000132879" "FBXO44" "B3KNZ2; B7Z743; hsa:93611; Q5TGX2; Q5TGX4; Q5TGX5; Q68DJ9; Q8WWY2; Q9H4M3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.798" "0.913" "0.934" "0.926" "0.902" "1.110" "0.858" "0.961" "1.182" "49.2" "39.3" "44.9" "46.0" "45.6" "44.4" "54.6" "42.2" "47.3" "58.2" "" "" "" "" "" "" "" "" "" "" "44.3" "31.8" "40.7" "44.9" "37.6" "44.4" "40.9" "37.3" "42.4" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4045203445570515749" "False" "High" "IsMasterProtein" "Q9BQ49" "Small integral membrane protein 7 OS=Homo sapiens OX=9606 GN=SMIM7 PE=1 SV=2" "0.003" "False" "3.577" "13" "1" "1" "1" "75" "8.6" "8.18" "3.26" "1" "" "other membranes" "" "" "79086" "ENSG00000214046" "SMIM7" "A8MX44; hsa:79086; Q9BQ49" "" "" "0" "0" "0.891" "0.854" "0.926" "0.881" "0.884" "0.865" "0.958" "0.945" "0.758" "58.6" "52.2" "50.0" "54.3" "51.6" "51.8" "50.7" "56.1" "55.4" "44.4" "" "" "" "" "" "" "" "" "" "" "52.7" "42.2" "45.3" "53.0" "42.6" "51.8" "37.9" "49.6" "49.5" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5644554619979627576" "False" "High" "IsMasterProtein" "O75251" "NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFS7 PE=1 SV=3" "0.003" "False" "3.576" "4" "1" "1" "1" "213" "23.5" "9.99" "3.57" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;mitochondrion;other cell component" "transporter activity;other molecular function" "Pf01058" "374291" "ENSG00000115286" "NDUFS7" "B3KRI2; hsa:374291; O75251; Q2T9H7; Q9BV17" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-864787675804904831" "False" "High" "IsMasterProtein" "Q8NDN9" "RCC1 and BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RCBTB1 PE=1 SV=1" "0.003" "False" "3.568" "2" "1" "2" "1" "531" "58.2" "6.47" "6.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "nucleus;other cell component" "" "Pf00415, Pf00651" "55213" "ENSG00000136144" "RCBTB1" "hsa:55213; Q8IY29; Q8NDN9; Q969U9" "Primary ovarian insufficiency" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1773776656278812315" "False" "High" "IsMasterProtein" "Q6DN90" "IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens OX=9606 GN=IQSEC1 PE=1 SV=1" "0.003" "False" "3.567" "1" "1" "1" "1" "963" "108.2" "6.93" "2.94" "1" "cell organization and biogenesis;developmental processes;other biological processes" "ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf01369, Pf16453" "9922" "ENSG00000144711" "IQSEC1" "A0A087WWK8; hsa:9922; O94863; Q6DN90; Q96D85" "EGF/EGFR signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9206715723484579630" "False" "High" "IsMasterProtein" "A0A087WW87" "Immunoglobulin kappa variable 2-40 OS=Homo sapiens OX=9606 GN=IGKV2-40 PE=3 SV=2" "0.003" "False" "3.565" "11" "1" "1" "1" "121" "13.3" "4.61" "3.43" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "" "Pf07686" "" "ENSG00000273962" "IGKV2-40" "A0A087WW87" "" "" "0" "0" "0.972" "1.035" "0.972" "1.113" "1.008" "1.060" "1.009" "1.165" "0.800" "100.7" "97.9" "104.2" "97.9" "112.0" "101.5" "106.8" "101.6" "117.3" "80.6" "" "" "" "" "" "" "" "" "" "" "90.5" "79.2" "94.2" "95.5" "92.5" "101.5" "79.9" "89.8" "105.0" "28.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7158809287201110390" "False" "High" "IsMasterProtein" "P49069" "Guided entry of tail-anchored proteins factor CAMLG OS=Homo sapiens OX=9606 GN=CAMLG PE=1 SV=1" "0.003" "False" "3.554" "3" "1" "1" "1" "296" "32.9" "8.05" "2.44" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;signal transduction;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf14963" "819" "ENSG00000164615" "CAMLG" "A1L3Y3; hsa:819; P49069" "" "Insertion of tail-anchored proteins into the endoplasmic reticulum membrane" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8336959389003651340" "False" "High" "IsMasterProtein" "Q9NZJ4" "Sacsin OS=Homo sapiens OX=9606 GN=SACS PE=1 SV=2" "0.003" "False" "3.551" "0" "1" "1" "1" "4579" "520.8" "7.05" "5.48" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00240, Pf05168" "26278" "ENSG00000151835" "SACS" "hsa:26278; O94835; Q5T9J5; Q5T9J7; Q5T9J8; Q68DF5; Q6MZR4; Q8NBF9; Q9NZJ4" "13q12.12 copy number variation" "" "1" "0" "0.909" "1.012" "0.838" "0.931" "0.963" "0.920" "0.967" "1.026" "1.371" "102.5" "93.2" "103.8" "85.9" "95.5" "98.7" "94.3" "99.2" "105.2" "140.6" "" "" "" "" "" "" "" "" "" "" "92.2" "75.4" "93.9" "83.9" "78.8" "98.7" "70.6" "87.6" "94.2" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8556034775710589228" "False" "High" "IsMasterProtein" "Q8TF74" "WAS/WASL-interacting protein family member 2 OS=Homo sapiens OX=9606 GN=WIPF2 PE=1 SV=1" "0.003" "False" "3.544" "2" "1" "1" "1" "440" "46.3" "10.93" "3.27" "1" "" "cytosol;cytoskeleton" "cytoskeletal activity" "Pf02205" "147179" "ENSG00000171475" "WIPF2" "A8K0L3; hsa:147179; Q658J8; Q71RE1; Q8TE44; Q8TF74" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOJ GTPase cycle" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5038635126872872861" "False" "High" "IsMasterProtein" "O15015" "Zinc finger protein 646 OS=Homo sapiens OX=9606 GN=ZNF646 PE=1 SV=2" "0.003" "False" "3.540" "1" "1" "1" "1" "1832" "200.7" "7.21" "3.08" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13912" "9726" "ENSG00000167395" "ZNF646" "hsa:9726; O15015; Q8IVD8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3573603970106114423" "False" "High" "IsMasterProtein" "Q9H2F5" "Enhancer of polycomb homolog 1 OS=Homo sapiens OX=9606 GN=EPC1 PE=1 SV=1" "0.003" "False" "3.537" "1" "1" "1" "1" "836" "93.4" "8.59" "2.85" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "other membranes;nucleus;other cell component" "other molecular function" "Pf06752, Pf10513" "80314" "ENSG00000120616" "EPC1" "B4DSC3; D3DRX7; hsa:80314; Q5VW54; Q5VW56; Q5VW58; Q8NAQ4; Q8NE21; Q96LF4; Q96RR6; Q9H2F5; Q9H7T7" "" "Transcriptional Regulation by E2F6; HATs acetylate histones" "2" "0" "1.135" "1.074" "0.994" "1.086" "0.969" "1.094" "0.984" "1.088" "2.116" "91.0" "103.3" "97.8" "90.5" "98.9" "88.2" "99.5" "89.6" "99.1" "192.6" "" "" "" "" "" "" "" "" "" "" "81.8" "83.6" "88.4" "88.3" "81.6" "88.2" "74.5" "79.1" "88.6" "68.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "478147103131354845" "False" "High" "IsMasterProtein" "Q4KMQ1" "Taperin OS=Homo sapiens OX=9606 GN=TPRN PE=1 SV=2" "0.003" "False" "3.536" "2" "1" "1" "1" "711" "75.5" "7.25" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "other molecular function" "Pf13914, Pf13916" "286262" "ENSG00000176058" "TPRN" "B7ZKU5; hsa:286262; Q4KMQ1; Q5VSG5; Q5VSG6; Q6IPP2; Q8NCH2" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "1.085" "1.284" "1.012" "1.087" "1.078" "1.080" "1.099" "1.193" "1.252" "47.9" "51.9" "61.5" "48.4" "52.0" "51.6" "51.7" "52.6" "57.1" "59.9" "" "" "" "" "" "" "" "" "" "" "43.0" "42.0" "55.6" "47.3" "42.9" "51.6" "38.7" "46.5" "51.1" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5068245923404983933" "False" "High" "IsMasterProtein" "P53671" "LIM domain kinase 2 OS=Homo sapiens OX=9606 GN=LIMK2 PE=1 SV=1" "0.003" "False" "3.535" "1" "1" "1" "1" "638" "72.2" "7.20" "2.35" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00412, Pf00595, Pf07714" "3985" "ENSG00000182541" "LIMK2" "A8K6H5; hsa:3985; P53671; Q7KZ80; Q7L3H5; Q96E10; Q99464; Q9UFU0" "Androgen receptor signaling pathway; TGF-beta signaling pathway; EGF/EGFR signaling pathway" "EPHB-mediated forward signaling; Sema4D induced cell migration and growth-cone collapse; RHO GTPases Activate ROCKs" "6" "0" "1.021" "0.881" "0.808" "1.005" "0.889" "0.782" "0.743" "0.967" "1.278" "113.0" "115.4" "99.6" "91.3" "113.6" "100.5" "88.3" "84.0" "109.3" "144.4" "" "" "" "" "" "" "" "" "" "" "101.6" "93.4" "90.1" "89.1" "93.7" "100.5" "66.1" "74.2" "97.8" "51.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1090044883093451685" "False" "High" "IsMasterProtein" "Q6PGQ7" "Protein aurora borealis OS=Homo sapiens OX=9606 GN=BORA PE=1 SV=2" "0.003" "False" "3.527" "2" "1" "1" "1" "559" "61.2" "4.94" "3.74" "1" "cell cycle OR cell proliferation;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15280" "79866" "ENSG00000136122" "BORA" "B4DQ30; hsa:79866; Q5W0P3; Q5W0P4; Q6PGQ7; Q86YC6; Q96IW9; Q9H640" "" "Regulation of PLK1 Activity at G2/M Transition" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3254611339716425510" "False" "High" "IsMasterProtein" "Q96FE7" "Phosphoinositide-3-kinase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PIK3IP1 PE=1 SV=2" "0.003" "False" "3.527" "4" "1" "1" "1" "263" "28.2" "5.01" "4.00" "1" "other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00051" "113791" "ENSG00000100100" "PIK3IP1" "B4DRR9; D1MEI0; hsa:113791; O00318; Q49A94; Q86YW2; Q8NCJ9; Q96FE7" "Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2516940427401881470" "False" "High" "IsMasterProtein" "Q13615" "Myotubularin-related protein 3 OS=Homo sapiens OX=9606 GN=MTMR3 PE=1 SV=3" "0.003" "False" "3.524" "1" "1" "2" "1" "1198" "133.5" "5.80" "7.41" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf01363, Pf06602" "8897" "ENSG00000100330" "MTMR3" "A5PL26; A7MD32; hsa:8897; Q13615; Q9NYN5; Q9NYN6; Q9UDX6; Q9UEG3" "" "Synthesis of PIPs at the plasma membrane; Macroautophagy" "2" "0" "1.171" "1.044" "1.347" "1.150" "0.933" "0.962" "1.487" "0.810" "1.023" "12.5" "14.6" "13.0" "16.8" "14.4" "11.6" "12.0" "18.6" "10.1" "12.8" "" "" "" "" "" "" "" "" "" "" "11.2" "11.8" "11.8" "16.4" "11.8" "11.6" "9.0" "16.4" "9.0" "4.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6180191668945880169" "False" "High" "IsMasterProtein" "Q9H269" "Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens OX=9606 GN=VPS16 PE=1 SV=2" "0.003" "False" "3.521" "1" "1" "1" "1" "839" "94.6" "6.77" "3.70" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf04840, Pf04841" "64601" "ENSG00000215305" "VPS16" "hsa:64601; Q5JUB1; Q8WU31; Q96EE7; Q96N92; Q9H1Q4; Q9H1Q5; Q9H269" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "1.188" "1.148" "1.010" "1.094" "1.159" "1.108" "1.143" "1.173" "1.482" "160.3" "190.3" "184.0" "161.9" "175.3" "185.7" "177.5" "183.1" "188.0" "237.5" "" "" "" "" "" "" "" "" "" "" "144.1" "154.0" "166.5" "158.0" "144.7" "185.7" "132.9" "161.7" "168.2" "84.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6647078469160461011" "False" "High" "IsMasterProtein" "Q00722" "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 OS=Homo sapiens OX=9606 GN=PLCB2 PE=1 SV=2" "0.003" "False" "3.515" "1" "1" "1" "1" "1185" "133.9" "6.29" "3.39" "1" "other metabolic processes;transport;signal transduction;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00168, Pf00387, Pf00388, Pf08703, Pf09279, Pf17787" "5330" "ENSG00000137841" "PLCB2" "A8K6J2; B9EGH5; Q00722" "MicroRNAs in cardiomyocyte hypertrophy; Alzheimer's disease and miRNA effects; S1P receptor signal transduction; Chemokine signaling pathway; GPR40 pathway; Wnt signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Resistin as a regulator of inflammation; Hippo signaling regulation pathways; PKC-gamma calcium signaling pathway in ataxia; Kisspeptin/kisspeptin receptor system in the ovary; GPR143 in melanocytes and retinal pigment epithelium cells; Neuroinflammation and glutamatergic signaling; Alzheimer's disease" "PLC beta mediated events; G alpha (q) signalling events; Sensory perception of sweet, bitter, and umami (glutamate) taste; Ca2+ pathway; G beta:gamma signalling through PLC beta; Presynaptic function of Kainate receptors; Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion; Synthesis of IP3 and IP4 in the cytosol; Acetylcholine regulates insulin secretion" "23" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8694247867552348247" "False" "High" "IsMasterProtein" "Q9BQ75" "Protein CMSS1 OS=Homo sapiens OX=9606 GN=CMSS1 PE=1 SV=2" "0.003" "False" "3.511" "4" "1" "1" "1" "279" "31.9" "9.19" "3.63" "1" "" "" "" "Pf14617" "84319" "ENSG00000184220" "CMSS1" "A8K5S7; B4DUM1; E9PHS3; hsa:84319; Q9BQ75" "" "" "0" "0" "0.986" "0.845" "0.972" "0.942" "0.932" "0.955" "0.834" "0.837" "0.949" "228.4" "225.1" "193.1" "222.0" "215.2" "213.0" "218.0" "190.5" "191.0" "216.8" "" "" "" "" "" "" "" "" "" "" "205.3" "182.2" "174.7" "216.7" "177.6" "213.0" "163.2" "168.3" "170.9" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660513057168003161" "False" "High" "IsMasterProtein" "Q99805" "Transmembrane 9 superfamily member 2 OS=Homo sapiens OX=9606 GN=TM9SF2 PE=1 SV=1" "0.003" "False" "3.511" "2" "1" "1" "1" "663" "75.7" "7.44" "3.69" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9375" "ENSG00000125304" "TM9SF2" "A8K399; hsa:9375; Q2TAY5; Q99805" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5634766023329637374" "False" "High" "IsMasterProtein" "Q9HAF1" "Chromatin modification-related protein MEAF6 OS=Homo sapiens OX=9606 GN=MEAF6 PE=1 SV=1" "0.003" "False" "3.510" "9" "2" "2" "2" "191" "21.6" "9.32" "3.56" "2" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "" "Pf09340" "64769" "ENSG00000163875" "MEAF6" "B1AK64; hsa:64769; Q4F967; Q7Z311; Q86WE3; Q9HAF1" "" "HATs acetylate histones; Regulation of TP53 Activity through Acetylation" "2" "0" "0.853" "0.963" "0.937" "1.035" "0.973" "0.805" "0.873" "0.959" "0.772" "68.3" "58.2" "65.8" "63.9" "70.6" "66.4" "55.0" "59.6" "65.5" "52.7" "" "" "" "" "" "" "" "" "" "" "61.4" "47.1" "59.5" "62.4" "58.3" "66.4" "41.2" "52.7" "58.6" "18.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2519239188729855809" "False" "High" "IsMasterProtein" "Q8IXZ2" "Zinc finger CCCH domain-containing protein 3 OS=Homo sapiens OX=9606 GN=ZC3H3 PE=1 SV=3" "0.003" "False" "3.503" "2" "2" "2" "2" "948" "101.9" "10.95" "2.04" "2" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00642" "23144" "ENSG00000014164" "ZC3H3" "hsa:23144; Q14163; Q8IXZ2; Q8N4E2; Q9BUS4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1129422898553958470" "False" "High" "IsMasterProtein" "Q86VX9" "Vacuolar fusion protein MON1 homolog A OS=Homo sapiens OX=9606 GN=MON1A PE=1 SV=3" "0.003" "False" "3.499" "2" "1" "1" "1" "652" "72.8" "8.18" "5.26" "1" "transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf19036, Pf19037, Pf19038" "84315" "ENSG00000164077" "MON1A" "B2RDQ1; G5E9N1; hsa:84315; Q86VX9; Q8NAV7; Q9BRF3; X6R3V9" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1604052202135203910" "False" "High" "IsMasterProtein" "O00592" "Podocalyxin OS=Homo sapiens OX=9606 GN=PODXL PE=1 SV=2" "0.003" "False" "3.499" "2" "1" "1" "1" "558" "58.6" "5.49" "3.30" "1" "cell adhesion;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "" "Pf06365" "5420" "ENSG00000128567" "PODXL" "A6NHX8; hsa:5420; O00592; Q52LZ7; Q53ER6" "Primary focal segmental glomerulosclerosis (FSGS); Ectoderm differentiation; Hepatitis C and hepatocellular carcinoma; Nephrotic syndrome; Pleural mesothelioma" "" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8960608706317852180" "False" "High" "IsMasterProtein" "A1L188" "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 OS=Homo sapiens OX=9606 GN=NDUFAF8 PE=1 SV=1" "0.003" "False" "3.499" "15" "1" "1" "1" "74" "7.8" "9.32" "2.62" "1" "cell organization and biogenesis" "mitochondrion" "" "" "284184" "ENSG00000224877" "NDUFAF8" "A1L188; hsa:284184" "" "" "0" "0" "1.161" "1.091" "0.885" "0.914" "1.289" "1.124" "1.085" "0.937" "0.860" "23.6" "27.4" "25.8" "20.9" "21.6" "30.5" "26.6" "25.6" "22.2" "20.3" "" "" "" "" "" "" "" "" "" "" "21.3" "22.2" "23.3" "20.4" "17.8" "30.5" "19.9" "22.7" "19.8" "7.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1245532746290238029" "False" "High" "IsMasterProtein" "P61353" "Large ribosomal subunit protein eL27 OS=Homo sapiens OX=9606 GN=RPL27 PE=1 SV=2" "0.003" "False" "3.495" "7" "1" "1" "1" "136" "15.8" "10.56" "4.13" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00467, Pf01777" "6155" "ENSG00000131469" "RPL27" "hsa:6155; P08526; P61353; Q4G0A9" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; L13a-mediated translational silencing of Ceruloplasmin expression; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Response of EIF2AK4 (GCN2) to amino acid deficiency; Formation of a pool of free 40S subunits; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "0.763" "0.785" "0.830" "0.904" "0.733" "0.813" "0.839" "0.713" "0.853" "266.2" "203.1" "208.9" "220.9" "240.7" "195.0" "216.4" "223.3" "189.7" "227.1" "" "" "" "" "" "" "" "" "" "" "239.3" "164.3" "189.0" "215.7" "198.7" "195.0" "162.1" "197.2" "169.7" "81.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "53418054531759760" "False" "High" "IsMasterProtein" "Q86Y79" "Peptidyl-tRNA hydrolase OS=Homo sapiens OX=9606 GN=PTRH1 PE=1 SV=1" "0.003" "False" "3.492" "5" "1" "1" "1" "214" "22.9" "10.56" "3.32" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "" "other molecular function" "Pf01195" "138428" "ENSG00000187024" "PTRH1" "hsa:138428; Q86Y79" "" "" "0" "0" "1.071" "1.068" "0.927" "1.060" "1.107" "1.248" "1.046" "1.246" "1.133" "62.3" "66.7" "66.5" "57.7" "66.0" "69.0" "77.7" "65.2" "77.6" "70.6" "" "" "" "" "" "" "" "" "" "" "56.0" "54.0" "60.2" "56.3" "54.5" "69.0" "58.2" "57.6" "69.4" "25.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3159074218320120217" "False" "High" "IsMasterProtein" "A8MT69" "Centromere protein X OS=Homo sapiens OX=9606 GN=CENPX PE=1 SV=1" "0.003" "False" "3.489" "11" "1" "1" "1" "81" "9.0" "5.90" "3.64" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09415" "201254" "ENSG00000169689" "CENPX" "A8MT69; hsa:201254; O00281; O00282; Q96DD4; Q96F51" "DNA repair pathways, full network" "Fanconi Anemia Pathway; PKR-mediated signaling; Deposition of new CENPA-containing nucleosomes at the centromere" "4" "0" "1.016" "1.109" "0.847" "0.994" "1.093" "1.074" "0.987" "1.008" "0.826" "109.9" "111.6" "121.9" "93.1" "109.3" "120.1" "118.1" "108.5" "110.8" "90.8" "" "" "" "" "" "" "" "" "" "" "98.8" "90.3" "110.2" "90.9" "90.2" "120.1" "88.4" "95.8" "99.2" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1437377503696460912" "False" "High" "IsMasterProtein" "Q6Q0C0" "E3 ubiquitin-protein ligase TRAF7 OS=Homo sapiens OX=9606 GN=TRAF7 PE=1 SV=1" "0.003" "False" "3.482" "4" "1" "1" "1" "670" "74.6" "7.15" "4.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "other molecular function" "Pf00400, Pf13445" "84231" "ENSG00000131653" "TRAF7" "hsa:84231; Q6Q0C0; Q9H073" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "1.135" "1.247" "0.859" "1.117" "1.362" "1.132" "0.965" "1.056" "1.283" "23.3" "26.4" "29.0" "20.0" "26.0" "31.7" "26.4" "22.5" "24.6" "29.9" "" "" "" "" "" "" "" "" "" "" "20.9" "21.4" "26.3" "19.5" "21.5" "31.7" "19.7" "19.8" "22.0" "10.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5294040977581567700" "False" "High" "IsMasterProtein" "Q9HBF4" "Zinc finger FYVE domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ZFYVE1 PE=1 SV=1" "0.003" "False" "3.478" "1" "1" "1" "1" "777" "87.1" "7.42" "3.48" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "53349" "ENSG00000165861" "ZFYVE1" "hsa:53349; J3KNL9; Q8WYX7; Q96K57; Q9BXP9; Q9HBF4; Q9HCI3" "" "" "0" "0" "1.144" "1.080" "1.043" "1.038" "1.131" "1.090" "0.926" "1.180" "1.193" "58.7" "67.2" "63.5" "61.3" "61.0" "66.4" "64.0" "54.4" "69.3" "70.1" "" "" "" "" "" "" "" "" "" "" "52.8" "54.4" "57.4" "59.8" "50.3" "66.4" "47.9" "48.0" "62.0" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1629743064100226613" "False" "High" "IsMasterProtein" "Q8TAK5" "GA-binding protein subunit beta-2 OS=Homo sapiens OX=9606 GN=GABPB2 PE=1 SV=1" "0.003" "False" "3.474" "3" "1" "1" "1" "448" "48.6" "5.26" "3.38" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf12796" "126626" "ENSG00000143458" "GABPB2" "B1AVJ8; D3DV14; hsa:126626; Q8NAR5; Q8TAK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-3175328810645519172" "False" "High" "IsMasterProtein" "Q6PH81" "UPF0547 protein C16orf87 OS=Homo sapiens OX=9606 GN=C16orf87 PE=1 SV=1" "0.003" "False" "3.472" "8" "1" "1" "1" "154" "17.8" "10.07" "3.80" "1" "" "" "" "Pf10571" "388272" "ENSG00000155330" "C16orf87" "Q63HN9; Q6PH81" "" "" "0" "0" "0.970" "1.172" "0.940" "1.065" "1.069" "0.845" "0.861" "1.139" "1.182" "70.6" "68.5" "82.8" "66.4" "75.2" "75.5" "59.7" "60.8" "80.4" "83.5" "" "" "" "" "" "" "" "" "" "" "63.5" "55.4" "74.9" "64.8" "62.0" "75.5" "44.7" "53.7" "72.0" "29.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7425032110570727878" "False" "High" "IsMasterProtein" "Q96NT1" "Nucleosome assembly protein 1-like 5 OS=Homo sapiens OX=9606 GN=NAP1L5 PE=1 SV=1" "0.003" "False" "3.472" "7" "1" "1" "1" "182" "19.6" "4.21" "2.67" "1" "cell organization and biogenesis" "nucleus" "" "Pf00956" "266812" "ENSG00000177432" "NAP1L5" "hsa:266812; Q96NT1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2188123927045547815" "False" "High" "IsMasterProtein" "P51790" "H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens OX=9606 GN=CLCN3 PE=1 SV=2" "0.003" "False" "3.471" "1" "1" "1" "1" "818" "90.9" "6.28" "3.72" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00571, Pf00654" "1182" "ENSG00000109572" "CLCN3" "B7Z932; B9EGJ9; D3DP34; E9PB97; hsa:1182; O14918; P51790; Q86Z21" "TAR syndrome" "Stimuli-sensing channels" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6296603921804072395" "False" "High" "IsMasterProtein" "Q9NSV4" "Protein diaphanous homolog 3 OS=Homo sapiens OX=9606 GN=DIAPH3 PE=1 SV=4" "0.003" "False" "3.471" "1" "2" "2" "1" "1193" "136.8" "7.03" "5.11" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf02181, Pf06367, Pf06371" "81624" "ENSG00000139734" "DIAPH3" "A2A3B8; A2A3B9; A2A3C0; hsa:81624; Q18P99; Q18PA0; Q18PA1; Q2KPB6; Q3ZK23; Q5JTP8; Q5T2S7; Q5XKF6; Q6MZF0; Q6NUP0; Q86VS4; Q8NAV4; Q9NSV4" "Regulation of actin cytoskeleton" "RHO GTPases Activate Formins; RHOC GTPase cycle; RHOA GTPase cycle; CDC42 GTPase cycle; RAC1 GTPase cycle; RHOQ GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOJ GTPase cycle; RHOF GTPase cycle" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5939280561053710644" "False" "High" "IsMasterProtein" "Q9P0T4" "Zinc finger protein 581 OS=Homo sapiens OX=9606 GN=ZNF581 PE=1 SV=1" "0.003" "False" "3.458" "5" "1" "1" "1" "197" "22.0" "8.82" "3.16" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13894" "51545" "ENSG00000171425" "ZNF581" "B2RDM6; hsa:51545; Q9P0T4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-767357545140157834" "False" "High" "IsMasterProtein" "P51784" "Ubiquitin carboxyl-terminal hydrolase 11 OS=Homo sapiens OX=9606 GN=USP11 PE=1 SV=3" "0.003" "False" "3.448" "1" "1" "1" "1" "963" "109.7" "5.45" "2.74" "1" "protein metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443, Pf06337, Pf14533, Pf14836" "" "ENSG00000102226" "USP11" "B2RTX1; P51784; Q8IUG6; Q9BWE1" "" "Ub-specific processing proteases; Association of TriC/CCT with target proteins during biosynthesis" "2" "0" "1.146" "1.227" "0.827" "1.061" "0.981" "0.901" "0.954" "1.177" "4.756" "95.1" "109.0" "116.7" "78.7" "101.0" "93.4" "85.7" "90.7" "112.0" "452.5" "" "" "" "" "" "" "" "" "" "" "85.5" "88.2" "105.6" "76.8" "83.3" "93.4" "64.2" "80.2" "100.2" "161.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7527749598789379160" "False" "High" "IsMasterProtein" "O75570" "Peptide chain release factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=MTRF1 PE=1 SV=2" "0.003" "False" "3.446" "4" "1" "1" "1" "445" "52.3" "8.50" "2.09" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "nucleic acid binding activity" "Pf00472, Pf03462" "9617" "ENSG00000120662" "MTRF1" "B4DG01; hsa:9617; O75570; Q5T6Y5; Q8IUQ6" "" "" "0" "0" "1.000" "0.939" "1.083" "1.015" "0.978" "1.025" "0.914" "0.870" "0.885" "71.4" "71.4" "67.0" "77.3" "72.4" "69.8" "73.2" "65.2" "62.1" "63.2" "" "" "" "" "" "" "" "" "" "" "64.2" "57.8" "60.6" "75.5" "59.8" "69.8" "54.8" "57.6" "55.5" "22.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7474037307863270970" "False" "High" "IsMasterProtein" "Q96TC7" "Regulator of microtubule dynamics protein 3 OS=Homo sapiens OX=9606 GN=RMDN3 PE=1 SV=2" "0.003" "False" "3.440" "4" "1" "1" "1" "470" "52.1" "5.10" "2.71" "1" "other biological processes" "other membranes;cytoskeleton;mitochondrion;nucleus;other cell component" "cytoskeletal activity" "Pf21033" "55177" "ENSG00000137824" "RMDN3" "A9UMZ9; B3KRR3; hsa:55177; Q6ZWE9; Q96H23; Q96SD6; Q96TC7; Q9H6G1; Q9NVQ6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5334275938705899592" "False" "High" "IsMasterProtein" "O00512" "B-cell CLL/lymphoma 9 protein OS=Homo sapiens OX=9606 GN=BCL9 PE=1 SV=4" "0.003" "False" "3.440" "1" "1" "1" "1" "1426" "149.2" "8.91" "3.01" "1" "cell-cell signaling;RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf11502" "607" "ENSG00000116128" "BCL9" "hsa:607; O00512; Q5T489" "Wnt signaling pathway; Wnt/beta-catenin signaling pathway in leukemia; 1q21.1 copy number variation syndrome" "Formation of the beta-catenin:TCF transactivating complex; Deactivation of the beta-catenin transactivating complex" "5" "0" "0.813" "1.155" "0.906" "0.613" "1.075" "1.140" "1.018" "1.237" "1.032" "17.6" "14.4" "20.4" "16.0" "10.8" "19.0" "20.1" "18.0" "21.8" "18.2" "" "" "" "" "" "" "" "" "" "" "15.9" "11.6" "18.4" "15.6" "8.9" "19.0" "15.1" "15.9" "19.5" "6.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "606148927883674097" "False" "High" "IsMasterProtein" "Q96AD5" "Patatin-like phospholipase domain-containing protein 2 OS=Homo sapiens OX=9606 GN=PNPLA2 PE=1 SV=1" "0.003" "False" "3.438" "3" "1" "1" "1" "504" "55.3" "7.08" "2.41" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01734" "57104" "ENSG00000177666" "PNPLA2" "hsa:57104; O60643; Q5EFF5; Q6XYE5; Q96AD5; Q96ET6; Q9NQ61; Q9NQ62" "Fatty acid beta-oxidation; Triacylglyceride synthesis; Lipid metabolism pathway; Thermogenesis; Glycerolipids and glycerophospholipids; Familial partial lipodystrophy; 5q35 copy number variation" "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Acyl chain remodeling of DAG and TAG" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9007576609156077388" "False" "High" "IsMasterProtein" "Q9UN70" "Protocadherin gamma-C3 OS=Homo sapiens OX=9606 GN=PCDHGC3 PE=1 SV=1" "0.003" "False" "3.436" "3" "2" "2" "1" "934" "101.0" "5.21" "0.00" "2" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974, Pf16492" "5098" "ENSG00000240184" "PCDHGC3" "hsa:5098; O60622; Q08192; Q9UN70; Q9Y5C4" "" "" "0" "1" "1.028" "0.950" "0.953" "0.975" "0.800" "0.969" "0.881" "0.979" "0.982" "465.8" "478.6" "442.6" "443.8" "454.2" "372.8" "451.2" "410.5" "455.9" "457.5" "" "" "" "" "" "" "" "" "" "" "418.8" "387.3" "400.4" "433.2" "374.8" "372.8" "337.9" "362.5" "407.9" "163.3" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6321776130452368548" "False" "High" "IsMasterProtein" "Q9H7Z6" "Histone acetyltransferase KAT8 OS=Homo sapiens OX=9606 GN=KAT8 PE=1 SV=2" "0.003" "False" "3.430" "2" "1" "1" "1" "458" "52.4" "8.27" "2.59" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01853, Pf11717, Pf17772" "84148" "ENSG00000103510" "KAT8" "A8K4Z1; G5E9P2; hsa:84148; Q659G0; Q7LC17; Q8IY59; Q8WYB4; Q8WZ14; Q9H7Z6; Q9HAC5; Q9NR35" "" "HATs acetylate histones; Formation of WDR5-containing histone-modifying complexes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "172063933685251467" "False" "High" "IsMasterProtein" "Q9BTA9" "WW domain-containing adapter protein with coiled-coil OS=Homo sapiens OX=9606 GN=WAC PE=1 SV=3" "0.003" "False" "3.426" "2" "1" "1" "1" "647" "70.7" "9.45" "2.20" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00397" "51322" "ENSG00000095787" "WAC" "A8K2A9; C9JBT9; D3DRW5; D3DRW6; D3DRW7; hsa:51322; Q53EN9; Q5JU75; Q5JU77; Q5VXK0; Q5VXK2; Q8TCK1; Q96DP3; Q96FW6; Q96JI3; Q9BTA9" "" "E3 ubiquitin ligases ubiquitinate target proteins" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2007985770655079458" "False" "High" "IsMasterProtein" "Q9BPX6" "Calcium uptake protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MICU1 PE=1 SV=1" "0.003" "False" "3.422" "3" "2" "2" "2" "476" "54.3" "8.41" "6.58" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf13202" "10367" "ENSG00000107745" "MICU1" "A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3; hsa:10367; O75785; Q9BPX6; Q9H9N6; Q9UFX0" "" "Processing of SMDT1" "2" "0" "0.885" "1.003" "0.793" "0.907" "0.938" "0.976" "0.977" "0.913" "1.041" "109.3" "96.7" "109.6" "86.7" "99.1" "102.5" "106.7" "106.8" "99.8" "113.8" "" "" "" "" "" "" "" "" "" "" "98.3" "78.2" "99.2" "84.6" "81.8" "102.5" "79.9" "94.3" "89.3" "40.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5094708502747754814" "False" "High" "IsMasterProtein" "P61313" "Large ribosomal subunit protein eL15 OS=Homo sapiens OX=9606 GN=RPL15 PE=1 SV=2" "0.003" "False" "3.421" "4" "1" "1" "1" "204" "24.1" "11.62" "3.52" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00827" "6138" "ENSG00000174748" "RPL15" "hsa:6138; P39030; P41051; P61313; Q5U0C0; Q642I1; Q6IPX6; Q8WYP2; Q96C44; Q9H2E5" "Cytoplasmic ribosomal proteins" "Major pathway of rRNA processing in the nucleolus and cytosol; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2433784342189097750" "False" "High" "IsMasterProtein" "Q96FJ0" "AMSH-like protease OS=Homo sapiens OX=9606 GN=STAMBPL1 PE=1 SV=2" "0.003" "False" "3.417" "4" "2" "2" "2" "436" "49.8" "7.23" "1.74" "2" "protein metabolism;other biological processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01398, Pf08969" "57559" "ENSG00000138134" "STAMBPL1" "B3KPA7; hsa:57559; Q5T9N4; Q5T9N9; Q7Z420; Q96FJ0; Q9P2H4" "TGF-beta signaling pathway" "Metalloprotease DUBs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3256135523585103311" "False" "High" "IsMasterProtein" "Q86XL3" "Ankyrin repeat and LEM domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ANKLE2 PE=1 SV=4" "0.003" "False" "3.415" "1" "1" "1" "1" "938" "104.1" "7.09" "3.32" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;ER/Golgi" "enzyme regulator activity;other molecular function" "Pf00023, Pf01693, Pf03020" "23141" "ENSG00000176915" "ANKLE2" "A8KAG3; B3KN97; B3KSF8; hsa:23141; O75176; Q6P6A5; Q86XL3; Q8TAZ9; Q96DH4" "" "RHOG GTPase cycle; RAC2 GTPase cycle; Initiation of Nuclear Envelope (NE) Reformation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8448471456180421378" "False" "High" "IsMasterProtein" "Q9P275" "Ubiquitin carboxyl-terminal hydrolase 36 OS=Homo sapiens OX=9606 GN=USP36 PE=1 SV=4" "0.003" "False" "3.413" "2" "2" "2" "2" "1123" "122.8" "9.70" "4.85" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00443" "57602" "ENSG00000055483" "USP36" "hsa:57602; Q05C98; Q05DD0; Q6IQ38; Q8NDM8; Q9NVC8; Q9P275" "" "" "0" "0" "0.820" "1.130" "1.137" "1.163" "1.364" "1.012" "1.209" "1.009" "0.921" "20.1" "16.5" "22.7" "22.8" "23.4" "27.4" "20.3" "24.3" "20.3" "18.5" "" "" "" "" "" "" "" "" "" "" "18.1" "13.3" "20.5" "22.3" "19.3" "27.4" "15.2" "21.5" "18.1" "6.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1190260410723795831" "False" "High" "IsMasterProtein" "Q14257" "Reticulocalbin-2 OS=Homo sapiens OX=9606 GN=RCN2 PE=1 SV=1" "0.003" "False" "3.407" "5" "1" "1" "1" "317" "36.9" "4.40" "3.42" "1" "" "ER/Golgi;nucleus" "other molecular function" "Pf13202, Pf13499" "5955" "ENSG00000117906" "RCN2" "A8MTG6; F8WCY5; hsa:5955; Q14257; Q53XN8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8574941110567403249" "False" "High" "IsMasterProtein" "Q9BUN5" "Coiled-coil domain-containing protein 28B OS=Homo sapiens OX=9606 GN=CCDC28B PE=1 SV=2" "0.003" "False" "3.403" "8" "1" "1" "1" "200" "22.0" "5.36" "2.80" "1" "cell organization and biogenesis" "cytoskeleton;other cell component" "" "Pf13270" "79140" "ENSG00000160050" "CCDC28B" "A8K789; hsa:79140; Q8TBV8; Q9BUN5" "Ciliopathies" "" "1" "0" "0.788" "1.245" "0.675" "0.980" "1.300" "0.647" "0.641" "1.223" "0.734" "20.4" "16.1" "25.5" "13.8" "20.0" "26.6" "13.2" "13.1" "25.0" "15.0" "" "" "" "" "" "" "" "" "" "" "18.4" "13.0" "23.0" "13.5" "16.5" "26.6" "9.9" "11.6" "22.4" "5.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4330254005621380904" "False" "High" "IsMasterProtein" "Q96BT3" "Centromere protein T OS=Homo sapiens OX=9606 GN=CENPT PE=1 SV=2" "0.003" "False" "3.400" "2" "1" "1" "1" "561" "60.4" "6.58" "2.50" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf15511, Pf16171" "80152" "ENSG00000102901" "CENPT" "hsa:80152; Q96BT3; Q96I29; Q96IC6; Q96NK9; Q9H901" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "1.237" "0.963" "0.923" "1.035" "1.139" "1.284" "1.026" "0.979" "0.702" "186.3" "230.5" "179.5" "171.9" "192.9" "212.3" "239.2" "191.3" "182.4" "130.9" "" "" "" "" "" "" "" "" "" "" "167.5" "186.5" "162.4" "167.8" "159.2" "212.3" "179.1" "169.0" "163.2" "46.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7060921209574590531" "False" "High" "IsMasterProtein" "Q01780" "Exosome complex component 10 OS=Homo sapiens OX=9606 GN=EXOSC10 PE=1 SV=2" "0.003" "False" "3.399" "1" "1" "1" "1" "885" "100.8" "8.46" "3.41" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf00570, Pf01612, Pf08066" "5394" "ENSG00000171824" "EXOSC10" "B1AKQ0; B1AKQ1; hsa:5394; Q01780; Q15158" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "660217191297362812" "False" "High" "IsMasterProtein" "P22695" "Cytochrome b-c1 complex subunit 2, mitochondrial OS=Homo sapiens OX=9606 GN=UQCRC2 PE=1 SV=3" "0.003" "False" "3.397" "3" "1" "1" "1" "453" "48.4" "8.63" "2.23" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;nucleus" "other molecular function" "Pf00675, Pf05193" "7385" "ENSG00000140740" "UQCRC2" "B3KSN4; hsa:7385; P22695; Q9BQ05" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Mitochondrial complex III assembly" "Mitochondrial protein degradation; Respiratory electron transport" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9027180669727079194" "False" "High" "IsMasterProtein" "Q5T280" "Putative methyltransferase C9orf114 OS=Homo sapiens OX=9606 GN=SPOUT1 PE=1 SV=3" "0.003" "False" "3.397" "3" "1" "1" "1" "376" "42.0" "7.43" "4.61" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf02598" "51490" "ENSG00000198917" "SPOUT1" "hsa:51490; Q0D2P6; Q5T280; Q6P469; Q6PGP9; Q6PIJ1; Q6PJV9" "" "" "0" "0" "1.118" "1.217" "1.008" "1.041" "1.106" "1.081" "0.901" "0.978" "1.125" "109.9" "122.9" "133.8" "110.8" "114.4" "121.6" "118.8" "99.0" "107.5" "123.7" "" "" "" "" "" "" "" "" "" "" "98.8" "99.5" "121.0" "108.1" "94.4" "121.6" "89.0" "87.4" "96.2" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-822484129541956869" "False" "High" "IsMasterProtein" "Q14149" "MORC family CW-type zinc finger protein 3 OS=Homo sapiens OX=9606 GN=MORC3 PE=1 SV=3" "0.003" "False" "3.394" "1" "1" "1" "1" "939" "107.0" "5.60" "3.13" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf07496, Pf13589, Pf17942" "23515" "ENSG00000159256" "MORC3" "A8KA92; hsa:23515; Q14149; Q9UEZ2" "Interactome of polycomb repressive complex 2 (PRC2)" "" "1" "0" "1.402" "1.204" "1.066" "1.204" "1.032" "1.148" "1.127" "1.108" "1.535" "73.2" "102.5" "88.1" "78.0" "88.1" "75.5" "84.0" "82.5" "81.1" "112.3" "" "" "" "" "" "" "" "" "" "" "65.8" "83.0" "79.7" "76.1" "72.7" "75.5" "62.9" "72.8" "72.5" "40.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7312432654099933298" "False" "High" "IsMasterProtein" "Q8WUF5" "RelA-associated inhibitor OS=Homo sapiens OX=9606 GN=PPP1R13L PE=1 SV=4" "0.003" "False" "3.391" "1" "1" "1" "1" "828" "89.0" "6.81" "3.53" "1" "developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12796, Pf14604" "10848" "ENSG00000104881" "PPP1R13L" "hsa:10848; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q8WUF5; Q9Y290" "IL-18 signaling pathway" "Regulation of TP53 Activity through Association with Co-factors" "2" "0" "1.005" "1.083" "1.010" "0.969" "1.088" "1.154" "1.003" "0.880" "1.074" "140.9" "141.6" "152.6" "142.3" "136.5" "153.3" "162.5" "141.3" "123.9" "151.3" "" "" "" "" "" "" "" "" "" "" "126.7" "114.6" "138.0" "138.9" "112.7" "153.3" "121.7" "124.8" "110.9" "54.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4293732190144876547" "False" "High" "IsMasterProtein" "P13498" "Cytochrome b-245 light chain OS=Homo sapiens OX=9606 GN=CYBA PE=1 SV=3" "0.003" "False" "3.383" "5" "1" "1" "1" "195" "21.0" "9.54" "4.42" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf05038" "1535" "ENSG00000051523" "CYBA" "hsa:1535; P13498; Q14090; Q9BR72" "TNF-alpha signaling pathway; Microglia pathogen phagocytosis pathway; Urotensin-II-mediated signaling pathway; Genetic causes of porto-sinusoidal vascular disease" "Neutrophil degranulation; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; Detoxification of Reactive Oxygen Species; VEGFA-VEGFR2 Pathway; WNT5:FZD7-mediated leishmania damping; ROS and RNS production in phagocytes; Cross-presentation of particulate exogenous antigens (phagosomes); RHO GTPases Activate NADPH Oxidases" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7892576250417935997" "False" "High" "IsMasterProtein" "A6NKD9" "Coiled-coil domain-containing protein 85C OS=Homo sapiens OX=9606 GN=CCDC85C PE=1 SV=1" "0.003" "False" "3.364" "3" "1" "1" "1" "419" "45.2" "6.96" "2.94" "1" "developmental processes" "other cell component" "" "Pf10226" "317762" "ENSG00000205476" "CCDC85C" "A6NKD9; hsa:317762" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2135832377467312061" "False" "High" "IsMasterProtein" "Q9UHC7" "E3 ubiquitin-protein ligase makorin-1 OS=Homo sapiens OX=9606 GN=MKRN1 PE=1 SV=3" "0.004" "False" "3.355" "2" "1" "2" "1" "482" "53.3" "5.14" "6.05" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf00097, Pf14608, Pf15815, Pf18044" "23608" "ENSG00000133606" "MKRN1" "A4D1T7; B3KXB4; Q256Y7; Q59G11; Q6GSF1; Q9H0G0; Q9UEZ7; Q9UHC7; Q9UHW2" "" "Antigen processing: Ubiquitination & Proteasome degradation; Regulation of PTEN stability and activity; AKT phosphorylates targets in the cytosol" "3" "0" "1.096" "0.777" "0.875" "0.967" "0.844" "1.155" "0.956" "0.913" "0.969" "110.4" "120.9" "85.7" "96.5" "106.7" "93.2" "127.4" "105.5" "100.8" "107.0" "" "" "" "" "" "" "" "" "" "" "99.2" "97.9" "77.6" "94.2" "88.1" "93.2" "95.4" "93.2" "90.2" "38.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3136372525851950601" "False" "High" "IsMasterProtein" "P0C7T5" "Ataxin-1-like OS=Homo sapiens OX=9606 GN=ATXN1L PE=1 SV=1" "0.004" "False" "3.346" "1" "1" "1" "1" "689" "73.3" "6.60" "2.02" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf08517, Pf12547" "342371" "ENSG00000224470" "ATXN1L" "hsa:342371; P0C7T5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8165689774405731487" "False" "High" "IsMasterProtein" "Q9NS18" "Glutaredoxin-2, mitochondrial OS=Homo sapiens OX=9606 GN=GLRX2 PE=1 SV=1" "0.004" "False" "3.345" "6" "1" "1" "1" "164" "18.0" "9.11" "3.46" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf00462" "51022" "ENSG00000023572" "GLRX2" "hsa:51022; Q3LR69; Q7L1N7; Q96JC0; Q9NS18; Q9Y3D4" "" "" "0" "0" "0.883" "1.012" "0.938" "1.011" "0.913" "0.888" "0.915" "1.055" "0.917" "107.3" "94.7" "108.6" "100.6" "108.4" "97.9" "95.2" "98.2" "113.2" "98.4" "" "" "" "" "" "" "" "" "" "" "96.4" "76.7" "98.2" "98.2" "89.5" "97.9" "71.3" "86.7" "101.3" "35.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431062919970507924" "False" "High" "IsMasterProtein" "P62891" "Large ribosomal subunit protein eL39 OS=Homo sapiens OX=9606 GN=RPL39 PE=1 SV=2" "0.004" "False" "3.342" "20" "1" "1" "1" "51" "6.4" "12.56" "5.27" "1" "protein metabolism;other metabolic processes;stress response" "non-structural extracellular;cytosol;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf00832" "6170" "ENSG00000198918" "RPL39" "hsa:6170; P02404; P39025; P62891; Q9BYF2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "1.172" "1.072" "0.996" "0.953" "1.027" "1.165" "1.015" "0.986" "1.031" "145.7" "170.8" "156.2" "145.1" "138.8" "149.6" "169.8" "147.9" "143.7" "150.3" "" "" "" "" "" "" "" "" "" "" "131.0" "138.2" "141.3" "141.7" "114.6" "149.6" "127.1" "130.7" "128.5" "53.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3780943028693763467" "False" "High" "IsMasterProtein" "Q9H009" "Nascent polypeptide-associated complex subunit alpha-2 OS=Homo sapiens OX=9606 GN=NACA2 PE=1 SV=1" "0.004" "False" "3.341" "4" "1" "3" "1" "215" "23.2" "4.73" "7.47" "1" "other biological processes" "translational apparatus;nucleus;other cell component" "other molecular function" "Pf01849, Pf19026" "342538" "ENSG00000253506" "NACA2" "hsa:342538; Q2VIR9; Q9H009" "" "" "0" "0" "0.982" "0.979" "1.033" "1.098" "0.850" "0.950" "0.913" "1.035" "1.005" "150.2" "147.5" "147.0" "155.1" "165.0" "127.7" "142.7" "137.2" "155.4" "151.0" "" "" "" "" "" "" "" "" "" "" "135.1" "119.3" "133.0" "151.4" "136.1" "127.7" "106.9" "121.2" "139.1" "53.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5747732458404138185" "False" "High" "IsMasterProtein" "Q9HBH5" "Retinol dehydrogenase 14 OS=Homo sapiens OX=9606 GN=RDH14 PE=1 SV=1" "0.004" "False" "3.341" "3" "1" "1" "1" "336" "36.8" "8.79" "3.27" "1" "other metabolic processes" "other membranes;cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00106" "57665" "ENSG00000240857" "RDH14" "hsa:57665; Q9HBH5" "" "RA biosynthesis pathway" "1" "0" "1.077" "1.105" "1.127" "1.001" "1.238" "1.082" "1.098" "1.174" "1.214" "71.1" "76.6" "78.6" "80.2" "71.3" "88.1" "77.0" "78.1" "83.6" "86.4" "" "" "" "" "" "" "" "" "" "" "64.0" "62.0" "71.1" "78.3" "58.8" "88.1" "57.6" "69.0" "74.8" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7785970027012849018" "False" "High" "IsMasterProtein" "A0JLT2" "Mediator of RNA polymerase II transcription subunit 19 OS=Homo sapiens OX=9606 GN=MED19 PE=1 SV=2" "0.004" "False" "3.336" "5" "1" "1" "1" "244" "26.3" "9.82" "3.83" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf10278" "219541" "ENSG00000156603" "MED19" "A0JLT2; hsa:219541; Q8IV02; Q8IZD1" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8397121068629851867" "False" "High" "IsMasterProtein" "Q86W74" "Ankyrin repeat domain-containing protein 46 OS=Homo sapiens OX=9606 GN=ANKRD46 PE=1 SV=2" "0.004" "False" "3.326" "4" "1" "1" "1" "228" "25.3" "5.73" "2.69" "1" "" "other membranes" "" "Pf12796" "157567" "ENSG00000186106" "ANKRD46" "hsa:157567; Q6P9B7; Q86W74" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7227303497452228744" "False" "High" "IsMasterProtein" "Q9P0S2" "Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=COX16 PE=1 SV=1" "0.004" "False" "3.325" "8" "1" "1" "1" "106" "12.3" "9.50" "3.38" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14138" "51241" "ENSG00000133983" "COX16" "A6NDT5; A8K3X8; B8XYC5; hsa:51241; Q9P0S2" "Mitochondrial complex IV assembly" "Cytoprotection by HMOX1; TP53 Regulates Metabolic Genes; Respiratory electron transport" "4" "0" "0.939" "0.879" "0.963" "0.899" "0.859" "0.842" "0.971" "0.858" "0.678" "248.4" "233.2" "218.2" "239.2" "223.3" "213.4" "209.1" "241.3" "213.1" "168.5" "" "" "" "" "" "" "" "" "" "" "223.3" "188.7" "197.4" "233.5" "184.3" "213.4" "156.6" "213.1" "190.7" "60.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1866024987760357114" "False" "High" "IsMasterProtein" "Q9Y2A7" "Nck-associated protein 1 OS=Homo sapiens OX=9606 GN=NCKAP1 PE=1 SV=1" "0.004" "False" "3.325" "1" "2" "3" "1" "1128" "128.7" "6.62" "7.99" "2" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf09735" "10787" "ENSG00000061676" "NCKAP1" "hsa:10787; O60329; Q53QN5; Q53S94; Q53Y35; Q9Y2A7" "Exercise-induced circadian regulation; Regulation of actin cytoskeleton" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RHO GTPases Activate WASPs and WAVEs; RAC1 GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; VEGFA-VEGFR2 Pathway" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8365125981762301712" "False" "High" "IsMasterProtein" "P52739" "Zinc finger protein 131 OS=Homo sapiens OX=9606 GN=ZNF131 PE=1 SV=2" "0.004" "False" "3.322" "2" "1" "1" "1" "623" "71.4" "5.19" "3.39" "1" "other biological processes" "cytoskeleton;nucleus" "nucleic acid binding activity;other molecular function" "Pf00651, Pf12874" "7690" "ENSG00000172262" "ZNF131" "B4DRL3; hsa:7690; P52739; Q6PIF0" "" "SUMOylation of transcription cofactors" "1" "0" "0.770" "1.043" "1.113" "1.267" "0.791" "1.292" "1.221" "0.742" "2.823" "27.8" "21.4" "29.0" "30.9" "35.2" "22.0" "35.9" "33.9" "20.6" "78.4" "" "" "" "" "" "" "" "" "" "" "25.0" "17.3" "26.2" "30.2" "29.0" "22.0" "26.9" "30.0" "18.4" "28.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7253720687934924150" "False" "High" "IsMasterProtein" "P19525" "Interferon-induced, double-stranded RNA-activated protein kinase OS=Homo sapiens OX=9606 GN=EIF2AK2 PE=1 SV=2" "0.004" "False" "3.321" "4" "2" "2" "2" "551" "62.1" "8.40" "6.26" "2" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;translational apparatus;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00035, Pf00069" "5610" "ENSG00000055332" "EIF2AK2" "A8K3P0; D6W584; E9PC80; hsa:5610; P19525; Q52M43; Q7Z6F6; Q9UIR4" "Translation factors; Alzheimer's disease and miRNA effects; PDGFR-beta pathway; Ebola virus infection in host; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction; Alzheimer's disease; Roles of ceramides in development of insulin resistance; Type II interferon signaling" "ISG15 antiviral mechanism; PKR-mediated signaling; Interferon alpha/beta signaling; Evasion by RSV of host interferon responses; Inhibition of PKR; SUMOylation of immune response proteins" "16" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5006155018502035980" "False" "High" "IsMasterProtein" "Q8WXI2" "Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens OX=9606 GN=CNKSR2 PE=1 SV=1" "0.004" "False" "3.321" "1" "1" "3" "1" "1034" "117.5" "6.79" "6.81" "1" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00169, Pf00536, Pf00595, Pf06663, Pf10534" "22866" "ENSG00000149970" "CNKSR2" "B4DGR4; B7ZLJ1; B9EG83; E7ESA4; hsa:22866; O94976; Q5JPK4; Q5JPN0; Q8WXI1; Q8WXI2" "" "Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants" "7" "0" "1.072" "0.960" "0.953" "1.022" "0.798" "0.974" "0.993" "1.039" "0.816" "758.7" "813.0" "728.6" "722.7" "775.6" "605.3" "739.1" "753.5" "788.3" "619.2" "" "" "" "" "" "" "" "" "" "" "682.1" "657.8" "659.1" "705.5" "640.0" "605.3" "553.4" "665.6" "705.4" "221.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2969987479368307007" "False" "High" "IsMasterProtein" "O14657" "Torsin-1B OS=Homo sapiens OX=9606 GN=TOR1B PE=1 SV=2" "0.004" "False" "3.315" "3" "1" "1" "1" "336" "38.0" "8.54" "2.02" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi;nucleus" "cytoskeletal activity;other molecular function" "Pf06309, Pf21376" "27348" "ENSG00000136816" "TOR1B" "hsa:27348; O14657" "" "Cargo recognition for clathrin-mediated endocytosis" "1" "0" "1.778" "1.420" "1.067" "1.851" "1.884" "1.517" "1.196" "1.786" "1.791" "76.6" "136.2" "108.7" "81.7" "141.8" "144.3" "116.2" "91.6" "136.8" "137.1" "" "" "" "" "" "" "" "" "" "" "68.9" "110.2" "98.4" "79.7" "117.0" "144.3" "87.0" "80.9" "122.4" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3249380285139605434" "False" "High" "IsMasterProtein" "Q96CB9" "5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens OX=9606 GN=NSUN4 PE=1 SV=2" "0.004" "False" "3.313" "2" "1" "1" "1" "384" "43.1" "8.18" "3.19" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion;translational apparatus" "nucleic acid binding activity;other molecular function" "Pf01189" "387338" "ENSG00000117481" "NSUN4" "A8K6S6; B3KQ50; B4DHA4; hsa:387338; Q5TDF7; Q96AN8; Q96CB9; Q9HAJ8" "" "rRNA modification in the mitochondrion" "1" "0" "1.035" "1.102" "0.927" "0.957" "1.048" "0.804" "0.873" "1.103" "0.864" "106.2" "109.9" "117.1" "98.5" "101.7" "111.3" "85.4" "92.7" "117.2" "91.8" "" "" "" "" "" "" "" "" "" "" "95.5" "88.9" "105.9" "96.1" "84.0" "111.3" "64.0" "81.9" "104.8" "32.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6585156526220186140" "False" "High" "IsMasterProtein" "Q13610" "Periodic tryptophan protein 1 homolog OS=Homo sapiens OX=9606 GN=PWP1 PE=1 SV=1" "0.004" "False" "3.308" "2" "1" "1" "1" "501" "55.8" "4.77" "2.07" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00400" "11137" "ENSG00000136045" "PWP1" "A8K3R6; hsa:11137; Q13610; Q7Z3X9" "" "" "0" "0" "0.992" "1.099" "0.791" "0.898" "0.941" "0.927" "0.919" "0.922" "0.832" "192.3" "190.7" "211.2" "152.2" "172.6" "180.9" "178.2" "176.8" "177.3" "160.0" "" "" "" "" "" "" "" "" "" "" "172.9" "154.3" "191.1" "148.5" "142.4" "180.9" "133.4" "156.1" "158.7" "57.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7794813676372242912" "False" "High" "IsMasterProtein" "Q96MW5" "Conserved oligomeric Golgi complex subunit 8 OS=Homo sapiens OX=9606 GN=COG8 PE=1 SV=2" "0.004" "False" "3.308" "2" "1" "1" "1" "612" "68.4" "5.20" "3.89" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;ER/Golgi" "" "Pf04124" "84342" "ENSG00000213380" "COG8" "hsa:84342; Q0VAK2; Q8WVV6; Q96MW5; Q9H6F8" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6039342044264890236" "False" "High" "IsMasterProtein" "Q99808" "Equilibrative nucleoside transporter 1 OS=Homo sapiens OX=9606 GN=SLC29A1 PE=1 SV=3" "0.004" "False" "3.306" "2" "1" "1" "1" "456" "50.2" "8.29" "4.18" "1" "cell-cell signaling;other metabolic processes;stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf01733" "2030" "ENSG00000112759" "SLC29A1" "B3KQV7; B3KQY5; hsa:2030; Q5T9W9; Q99808; Q9UJY2" "Fluoropyrimidine activity" "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane; Azathioprine ADME; Ribavirin ADME" "4" "0" "0.834" "0.826" "0.960" "0.832" "0.773" "0.875" "0.871" "0.988" "0.621" "184.2" "153.7" "152.1" "176.8" "153.2" "142.4" "161.2" "160.5" "182.0" "114.4" "" "" "" "" "" "" "" "" "" "" "165.6" "124.4" "137.6" "172.6" "126.4" "142.4" "120.7" "141.8" "162.8" "40.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5589324606331654897" "False" "High" "IsMasterProtein" "Q6P161" "Large ribosomal subunit protein mL54 OS=Homo sapiens OX=9606 GN=MRPL54 PE=1 SV=1" "0.004" "False" "3.300" "7" "1" "2" "1" "138" "15.8" "9.60" "6.36" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf08561" "116541" "ENSG00000183617" "MRPL54" "hsa:116541; Q6P161" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6924032991954886794" "False" "High" "IsMasterProtein" "Q92624" "Amyloid protein-binding protein 2 OS=Homo sapiens OX=9606 GN=APPBP2 PE=1 SV=2" "0.004" "False" "3.300" "1" "1" "1" "1" "585" "66.8" "6.90" "3.46" "1" "protein metabolism;other metabolic processes;transport" "other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf13374, Pf13424" "10513" "ENSG00000062725" "APPBP2" "A8K862; hsa:10513; O95095; Q8WVC9; Q92624" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1196962493120422710" "False" "High" "IsMasterProtein" "Q9BSF8" "BTB/POZ domain-containing protein 10 OS=Homo sapiens OX=9606 GN=BTBD10 PE=1 SV=2" "0.004" "False" "3.296" "2" "1" "1" "1" "475" "53.7" "7.77" "2.97" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "nucleus;other cell component" "" "Pf16017" "84280" "ENSG00000148925" "BTBD10" "B7Z228; hsa:84280; Q86WG1; Q9BSF8" "" "" "0" "0" "1.157" "1.008" "0.906" "0.958" "1.131" "1.034" "0.979" "1.230" "1.262" "48.2" "55.8" "48.6" "43.7" "46.2" "54.5" "49.9" "47.2" "59.4" "60.9" "" "" "" "" "" "" "" "" "" "" "43.4" "45.2" "44.0" "42.6" "38.1" "54.5" "37.4" "41.7" "53.1" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6633955161659000485" "False" "High" "IsMasterProtein" "O14662" "Syntaxin-16 OS=Homo sapiens OX=9606 GN=STX16 PE=1 SV=3" "0.004" "False" "3.295" "3" "1" "1" "1" "325" "37.0" "6.11" "3.00" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00804, Pf05739" "8675" "ENSG00000124222" "STX16" "A6NK32; A6NN69; A8MPP0; B7ZBN1; B7ZBN2; B7ZBN3; E1P5M0; E1P607; hsa:8675; O14661; O14662; O14663; O60517; Q5W084; Q5W086; Q5W087; Q5XKI6; Q6GMS8; Q9H0Z0; Q9H1T7; Q9H1T8; Q9UIX5" "Ectoderm differentiation" "Intra-Golgi traffic; Retrograde transport at the Trans-Golgi-Network" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7446156853799225344" "False" "High" "IsMasterProtein" "Q9C0D2" "Centrosomal protein of 295 kDa OS=Homo sapiens OX=9606 GN=CEP295 PE=1 SV=4" "0.004" "False" "3.285" "0" "2" "2" "1" "2601" "295.0" "6.00" "5.87" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf15309" "85459" "ENSG00000166004" "CEP295" "C9J5H9; C9JQY8; hsa:85459; Q8N7L4; Q8N919; Q8N9B0; Q96LT8; Q9C0D2" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "1.007" "0.951" "0.845" "1.007" "0.833" "0.899" "0.836" "0.974" "0.879" "121.1" "121.9" "115.1" "102.3" "121.9" "100.9" "108.9" "101.2" "117.9" "106.4" "" "" "" "" "" "" "" "" "" "" "108.8" "98.6" "104.1" "99.8" "100.6" "100.9" "81.5" "89.3" "105.5" "38.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3567391987631389580" "False" "High" "IsMasterProtein" "Q9BZA7" "Protocadherin-11 X-linked OS=Homo sapiens OX=9606 GN=PCDH11X PE=1 SV=1" "0.004" "False" "3.279" "1" "1" "3" "1" "1347" "147.5" "5.21" "5.31" "1" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf08374" "27328" "ENSG00000102290" "PCDH11X" "A6NIQ4; hsa:27328; Q2TJH0; Q2TJH1; Q2TJH3; Q5JVZ0; Q70LR8; Q70LS7; Q70LS8; Q70LS9; Q70LT7; Q70LT8; Q70LT9; Q70LU0; Q70LU1; Q96RV4; Q96RW0; Q9BZA6; Q9BZA7; Q9H4E0; Q9P2M0; Q9P2X5" "" "" "0" "0" "0.957" "0.892" "0.883" "1.127" "0.860" "0.925" "0.818" "0.907" "0.920" "103.3" "98.9" "92.1" "91.2" "116.5" "88.8" "95.6" "84.6" "93.8" "95.0" "" "" "" "" "" "" "" "" "" "" "92.9" "80.0" "83.3" "89.0" "96.1" "88.8" "71.6" "74.7" "83.9" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7713785017004630761" "False" "High" "IsMasterProtein" "Cont_P02662" "Alpha-S1-casein OS=Bos taurus OX=9913 GN=CSN1S1 PE=1 SV=2" "0.004" "True" "3.277" "5" "1" "1" "1" "214" "24.5" "5.02" "3.21" "1" "other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00363" "282208" "ENSBIXG00000025519; ENSBTAG00000007695" "CSN1S1" "A0A4W2EWY4; A5YK80; A8WCP1; A8WCP2; A8WCP3; A8WCP4; A8WCP5; A8WCP6; A8WCP7; A8WCP8; A8WCP9; A8WCQ0; A8WCQ1; A8WCQ2; A8WCQ3; A8WCQ4; A8WCQ5; A8WCQ6; A8WCQ7; A8WCQ8; A8WCQ9; A8WCR0; A8WCR1; A8WCR2; A8WCR3; A8WCR4; A8WCR5; A8WCR6; A8WCR7; A8WCR8; A8WCR9; A8WCS0; A8WCS1; bta:282208; P02662; Q28048; Q28069; Q32LE8; Q7M2U6; Q9TRH5" "" "Miscellaneous transport and binding events" "1" "0" "0.970" "0.884" "0.980" "0.837" "11.137" "0.731" "1.337" "0.899" "0.823" "49.6" "48.2" "43.9" "48.7" "41.6" "553.0" "36.3" "66.4" "44.6" "40.9" "" "" "" "" "" "" "" "" "" "" "44.6" "39.0" "39.7" "47.5" "34.3" "553.0" "27.2" "58.6" "39.9" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6012915059673315434" "False" "High" "IsMasterProtein" "Q9UBK8" "Methionine synthase reductase OS=Homo sapiens OX=9606 GN=MTRR PE=1 SV=4" "0.004" "False" "3.273" "2" "1" "1" "1" "698" "77.6" "6.49" "3.07" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton;nucleus" "other molecular function" "Pf00175, Pf00258, Pf00667" "4552" "ENSG00000124275" "MTRR" "hsa:4552; O60471; Q32MA9; Q7Z4M8; Q9UBK8" "Vitamin B12 metabolism; Folate metabolism; One-carbon metabolism; Male infertility; Spina bifida" "Methylation; Cobalamin (Cbl) metabolism; Sulfur amino acid metabolism; Defective MTRR causes HMAE; Defective MTR causes HMAG" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2682547924160316204" "False" "High" "IsMasterProtein" "Q8WVD5" "RING finger protein 141 OS=Homo sapiens OX=9606 GN=RNF141 PE=1 SV=1" "0.004" "False" "3.272" "4" "1" "1" "1" "230" "25.5" "5.20" "3.05" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes" "other molecular function" "Pf13639" "50862" "ENSG00000110315" "RNF141" "A8K149; hsa:50862; Q8WVD5; Q9NZB4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9028171991778450679" "False" "High" "IsMasterProtein" "P27540" "Aryl hydrocarbon receptor nuclear translocator OS=Homo sapiens OX=9606 GN=ARNT PE=1 SV=1" "0.004" "False" "3.270" "2" "1" "1" "1" "789" "86.6" "6.54" "3.72" "1" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf00010, Pf00989, Pf14598" "405" "ENSG00000143437" "ARNT" "B2R9H1; C4AMA1; F8WAP6; hsa:405; P27540; Q59ED4; Q5QP39; Q8NDC7" "Angiogenesis; Aryl hydrocarbon receptor pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Photodynamic therapy-induced HIF-1 survival signaling; VEGFA-VEGFR2 signaling; Clear cell renal cell carcinoma pathways; Type 2 papillary renal cell carcinoma; 6q16 copy number variation" "PPARA activates gene expression; NPAS4 regulates expression of target genes; Endogenous sterols; Xenobiotics; Aryl hydrocarbon receptor signalling; Regulation of gene expression by Hypoxia-inducible Factor" "16" "0" "0.963" "1.130" "0.908" "0.860" "1.158" "0.973" "0.949" "1.065" "1.082" "29.5" "28.5" "33.4" "26.8" "25.4" "34.2" "28.8" "28.0" "31.5" "32.0" "" "" "" "" "" "" "" "" "" "" "26.6" "23.0" "30.2" "26.2" "21.0" "34.2" "21.5" "24.8" "28.2" "11.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624211832406913783" "False" "High" "IsMasterProtein" "P15884" "Transcription factor 4 OS=Homo sapiens OX=9606 GN=TCF4 PE=1 SV=3" "0.004" "False" "3.260" "1" "1" "1" "1" "667" "71.3" "7.01" "3.55" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6925" "ENSG00000196628" "TCF4" "B3KT62; B3KUC0; B4DT37; B4DUG3; B7Z5M6; B7Z6Y1; G0LNT9; G0LNU0; G0LNU1; G0LNU2; G0LNU4; G0LNU5; G0LNU8; G0LNU9; G0LNV0; G0LNV1; G0LNV2; H3BPQ1; hsa:6925; P15884; Q08AP2; Q08AP3; Q15439; Q15440; Q15441" "Neural crest differentiation; Corticotropin-releasing hormone signaling pathway; Mesodermal commitment pathway; Wnt signaling pathway; Regulation of Wnt / B-catenin signaling by small molecule compounds; Development of pulmonary dendritic cells and macrophage subsets; Rett syndrome; Gastrin signaling pathway; Neurogenesis regulation in the olfactory epithelium" "Myogenesis" "10" "0" "1.225" "0.906" "0.970" "0.949" "0.950" "1.130" "1.011" "0.987" "3.579" "64.0" "78.4" "58.0" "62.1" "60.7" "60.8" "72.3" "64.7" "63.2" "229.1" "" "" "" "" "" "" "" "" "" "" "57.6" "63.5" "52.5" "60.6" "50.1" "60.8" "54.2" "57.2" "56.5" "81.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2567208340756626283" "False" "High" "IsMasterProtein" "Q8N128" "Protein FAM177A1 OS=Homo sapiens OX=9606 GN=FAM177A1 PE=1 SV=1" "0.004" "False" "3.260" "5" "1" "1" "1" "213" "23.7" "4.45" "2.75" "1" "" "" "" "Pf14774" "283635" "ENSG00000151327" "FAM177A1" "hsa:283635; Q68CT2; Q8N128" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4378027519318782833" "False" "High" "IsMasterProtein" "Q9H425" "Uncharacterized protein C1orf198 OS=Homo sapiens OX=9606 GN=C1orf198 PE=1 SV=1" "0.004" "False" "3.259" "3" "1" "1" "1" "327" "36.3" "5.72" "3.31" "1" "" "cytosol" "" "Pf15797" "84886" "ENSG00000119280" "C1orf198" "A8K8R8; B3KTW1; G5EA08; hsa:84886; Q9H425" "" "" "0" "0" "1.079" "1.241" "0.928" "1.016" "1.275" "0.985" "1.129" "1.135" "0.415" "69.4" "74.8" "86.1" "64.4" "70.5" "88.4" "68.3" "78.3" "78.7" "28.8" "" "" "" "" "" "" "" "" "" "" "62.4" "60.6" "77.9" "62.8" "58.2" "88.4" "51.2" "69.2" "70.4" "10.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-499196435734005468" "False" "High" "IsMasterProtein" "Q96GJ1" "tRNA (uracil-5-)-methyltransferase homolog B OS=Homo sapiens OX=9606 GN=TRMT2B PE=1 SV=1" "0.004" "False" "3.254" "2" "1" "1" "1" "504" "56.4" "8.81" "3.45" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "other molecular function" "Pf05958" "79979" "ENSG00000188917" "TRMT2B" "A6NDG5; A6NEI9; A6NMG6; hsa:79979; Q5JPF0; Q5JVY6; Q96GJ1; Q96HU7; Q96IH9; Q9H9K2" "" "" "0" "0" "1.045" "0.830" "0.897" "1.093" "0.812" "0.963" "0.989" "0.877" "0.907" "67.6" "70.6" "56.1" "60.6" "73.9" "54.8" "65.0" "66.8" "59.2" "61.3" "" "" "" "" "" "" "" "" "" "" "60.8" "57.1" "50.7" "59.2" "61.0" "54.8" "48.7" "59.0" "53.0" "21.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3037316955710450301" "False" "High" "IsMasterProtein" "P38936" "Cyclin-dependent kinase inhibitor 1 OS=Homo sapiens OX=9606 GN=CDKN1A PE=1 SV=3" "0.004" "False" "3.253" "11" "1" "1" "1" "164" "18.1" "8.37" "2.16" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf02234" "1026" "ENSG00000124762" "CDKN1A" "hsa:1026; P38936; Q14010; Q6FI05; Q9BUT4" "Androgen receptor signaling pathway; Androgen receptor signaling pathway; AMP-activated protein kinase signaling; miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Integrated cancer pathway; Glioblastoma signaling pathways; Adipogenesis; Retinoblastoma gene in cancer; ATM signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Bladder cancer; Apoptosis-related network due to altered Notch3 in ovarian cancer; Vitamin D receptor pathway; miR-517 relationship with ARCN1 and USP1; Photodynamic therapy-induced AP-1 survival signaling; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; lncRNA-mediated mechanisms of therapeutic resistance; Physico-chemical features and toxicity-associated pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Chromosomal and microsatellite instability in colorectal cancer ; Type 2 papillary renal cell carcinoma; Non-small cell lung cancer; Breast cancer pathway; Pancreatic adenocarcinoma pathway; G1 to S cell cycle control; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; Head and neck squamous cell carcinoma; Melanoma; FGFR3 signaling in chondrocyte proliferation and terminal differentiation; FGF23 signaling in hypophosphatemic rickets and related disorders; Overlap between signal transduction pathways contributing to LMNA laminopathies; p53 transcriptional gene network; Galanin receptor pathway; Pleural mesothelioma; Orexin receptor pathway; Lipid metabolism in senescent cells; Pathophysiological roles of DUX4 in FSHD1; Omega-6-fatty acids in senescence; Notch signaling pathway; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent); Androgen receptor signaling pathway" "Senescence-Associated Secretory Phenotype (SASP); TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; The role of GTSE1 in G2/M progression after G2 checkpoint; Neddylation; KEAP1-NFE2L2 pathway; Constitutive Signaling by AKT1 E17K in Cancer; SCF(Skp2)-mediated degradation of p27/p21; Signaling by ALK fusions and activated point mutants; Interleukin-4 and Interleukin-13 signaling; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; Transcriptional regulation by RUNX2; DNA Damage/Telomere Stress Induced Senescence; Transcriptional regulation of granulopoiesis; p53-Dependent G1 DNA Damage Response; TFAP2 (AP-2) family regulates transcription of cell cycle factors; Signaling by FLT3 fusion proteins; RUNX3 regulates CDKN1A transcription; Transcriptional activation of cell cycle inhibitor p21 ; STAT5 activation downstream of FLT3 ITD mutants" "79" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "Not Found" "High" "High" "High" "Not Found" "High" "Not Found" "1" "" "-2806721064947217400" "False" "High" "IsMasterProtein" "P0C024" "Peroxisomal coenzyme A diphosphatase NUDT7 OS=Homo sapiens OX=9606 GN=NUDT7 PE=1 SV=1" "0.004" "False" "3.249" "4" "1" "1" "1" "238" "26.9" "7.05" "3.78" "1" "other metabolic processes;other biological processes" "cytosol;other cytoplasmic organelle" "nucleic acid binding activity;other molecular function" "Pf00293" "283927" "ENSG00000140876" "NUDT7" "B4DLE5; H3BUB8; hsa:283927; P0C024" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "1.011" "0.954" "0.964" "1.248" "1.012" "1.117" "1.048" "1.037" "0.920" "89.2" "90.2" "85.0" "86.0" "111.3" "90.3" "99.6" "93.4" "92.5" "82.0" "" "" "" "" "" "" "" "" "" "" "80.2" "73.0" "76.9" "83.9" "91.9" "90.3" "74.6" "82.5" "82.7" "29.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6072914358106661187" "False" "High" "IsMasterProtein" "P86397" "Hydroxyacyl-thioester dehydratase type 2, mitochondrial OS=Homo sapiens OX=9606 GN=HTD2 PE=1 SV=1" "0.004" "False" "3.248" "17" "1" "1" "1" "168" "18.5" "8.92" "3.50" "1" "other metabolic processes" "mitochondrion;nucleus" "other molecular function" "Pf01575" "109703458" "ENSG00000255154" "HTD2" "P86397" "Mitochondrial fatty acid synthesis pathway" "Fatty acyl-CoA biosynthesis" "2" "0" "0.847" "0.982" "0.816" "1.027" "0.946" "0.923" "1.004" "1.037" "0.648" "21.9" "18.5" "21.5" "17.9" "22.5" "20.7" "20.2" "22.0" "22.7" "14.2" "" "" "" "" "" "" "" "" "" "" "19.7" "15.0" "19.4" "17.4" "18.5" "20.7" "15.1" "19.4" "20.3" "5.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8061362112935544067" "False" "High" "IsMasterProtein" "P43121" "Cell surface glycoprotein MUC18 OS=Homo sapiens OX=9606 GN=MCAM PE=1 SV=2" "0.004" "False" "3.247" "1" "1" "1" "1" "646" "71.6" "5.76" "3.35" "1" "cell adhesion;stress response;developmental processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "" "Pf07686, Pf08205, Pf13927" "4162" "ENSG00000076706" "MCAM" "hsa:4162; O95812; P43121; Q59E86; Q6PHR3; Q6ZTR2" "" "RHOC GTPase cycle; RHOA GTPase cycle; RAC1 GTPase cycle; RHOG GTPase cycle; RAC2 GTPase cycle; RAC3 GTPase cycle; RHOB GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle" "9" "0" "0.882" "0.869" "0.919" "0.859" "0.943" "1.076" "0.889" "0.971" "0.661" "94.8" "83.7" "82.4" "87.1" "81.5" "89.4" "102.0" "84.3" "92.1" "62.6" "" "" "" "" "" "" "" "" "" "" "85.3" "67.7" "74.6" "85.0" "67.2" "89.4" "76.4" "74.4" "82.4" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-173769377935829106" "False" "High" "IsMasterProtein" "Cont_P15497" "Apolipoprotein A-I OS=Bos taurus OX=9913 GN=APOA1 PE=1 SV=3" "0.004" "True" "3.240" "6" "2" "2" "1" "265" "30.3" "5.97" "4.75" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;other cell component" "signal transduction activity or receptor binding;transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "281631" "ENSBIXG00000010441; ENSBIXG00005004093; ENSBTAG00000002258" "APOA1" "A0A4W2DWW2; A5D7M9; bta:281631; P15497; Q3SZD9; V6F9A2" "Statin pathway; Folate metabolism; Vitamin B12 metabolism; Selenium micronutrient network" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation; Chylomicron assembly; Chylomicron remodeling; HDL remodeling; Retinoid metabolism and transport; HDL clearance; HDL assembly; Heme signaling; Scavenging by Class B Receptors" "15" "0" "1.376" "1.068" "1.192" "1.799" "1.289" "1.466" "1.273" "1.173" "1.123" "37.5" "51.6" "40.0" "44.6" "67.4" "48.3" "54.9" "47.7" "44.0" "42.1" "" "" "" "" "" "" "" "" "" "" "33.7" "41.7" "36.2" "43.6" "55.6" "48.3" "41.1" "42.1" "39.3" "15.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1157936408086935804" "False" "High" "IsMasterProtein" "O75446" "Histone deacetylase complex subunit SAP30 OS=Homo sapiens OX=9606 GN=SAP30 PE=1 SV=1" "0.004" "False" "3.234" "7" "2" "2" "2" "220" "23.3" "9.17" "5.34" "2" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13866, Pf13867" "8819" "ENSG00000164105" "SAP30" "D3DP38; hsa:8819; O75446" "Retinoblastoma gene in cancer; Notch signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression" "5" "0" "0.970" "0.953" "1.009" "1.001" "0.932" "0.989" "0.975" "0.929" "1.603" "432.0" "419.1" "411.8" "435.8" "432.6" "402.7" "427.4" "421.0" "401.2" "692.4" "" "" "" "" "" "" "" "" "" "" "388.5" "339.1" "372.5" "425.4" "357.0" "402.7" "320.0" "371.9" "359.0" "247.2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5885254063310961994" "False" "High" "IsMasterProtein" "Q6NXT1" "Ankyrin repeat domain-containing protein 54 OS=Homo sapiens OX=9606 GN=ANKRD54 PE=1 SV=2" "0.004" "False" "3.234" "4" "1" "1" "1" "300" "32.5" "6.28" "2.84" "1" "transport;other biological processes" "nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00023, Pf12796" "129138" "ENSG00000100124" "ANKRD54" "hsa:129138; Q6NXT1; Q6ZSB1; Q9UGV1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8802052166726839277" "False" "High" "IsMasterProtein" "O75884" "Serine hydrolase RBBP9 OS=Homo sapiens OX=9606 GN=RBBP9 PE=1 SV=2" "0.004" "False" "3.218" "5" "1" "1" "1" "186" "21.0" "6.20" "3.20" "1" "developmental processes;other biological processes" "nucleus" "other molecular function" "Pf06821" "10741" "ENSG00000089050" "RBBP9" "D3DW31; hsa:10741; O75884; Q5JPH9; Q9H1D8" "" "" "0" "0" "0.981" "1.053" "0.884" "1.065" "0.920" "1.059" "1.053" "0.946" "1.393" "173.4" "170.0" "182.5" "153.3" "184.7" "159.5" "183.7" "182.5" "164.1" "241.6" "" "" "" "" "" "" "" "" "" "" "155.9" "137.6" "165.1" "149.6" "152.4" "159.5" "137.5" "161.2" "146.8" "86.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8147219015132361751" "False" "High" "IsMasterProtein" "Q96A19" "Coiled-coil domain-containing protein 102A OS=Homo sapiens OX=9606 GN=CCDC102A PE=1 SV=2" "0.004" "False" "3.205" "2" "1" "1" "1" "550" "62.6" "5.58" "3.74" "1" "" "cytoskeleton" "" "Pf01576" "92922" "ENSG00000135736" "CCDC102A" "hsa:92922; Q96A19; Q9BT74" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7635059186967103870" "False" "High" "IsMasterProtein" "Q96PC3" "AP-1 complex subunit sigma-3 OS=Homo sapiens OX=9606 GN=AP1S3 PE=1 SV=1" "0.004" "False" "3.202" "6" "1" "2" "1" "154" "18.3" "6.79" "3.08" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01217" "130340" "ENSG00000152056" "AP1S3" "B4DQZ1; hsa:130340; Q8WTY1; Q96DD1; Q96PC3" "" "MHC class II antigen presentation; Lysosome Vesicle Biogenesis; Golgi Associated Vesicle Biogenesis; Nef mediated downregulation of MHC class I complex cell surface expression" "4" "0" "1.025" "0.970" "0.706" "1.043" "0.824" "0.949" "0.932" "0.837" "1.033" "80.3" "82.3" "77.8" "56.7" "83.7" "66.1" "76.2" "74.8" "67.2" "82.9" "" "" "" "" "" "" "" "" "" "" "72.2" "66.6" "70.4" "55.3" "69.1" "66.1" "57.0" "66.1" "60.2" "29.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8938944086695522358" "False" "High" "IsMasterProtein" "O75144" "ICOS ligand OS=Homo sapiens OX=9606 GN=ICOSLG PE=1 SV=2" "0.004" "False" "3.189" "3" "1" "1" "1" "302" "33.3" "5.31" "0.00" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf07686" "23308" "ENSG00000160223" "ICOSLG" "A8MUZ1; hsa:23308; O75144; Q9HD18; Q9NRQ1" "Extrafollicular and follicular B cell activation by SARS-CoV-2" "Costimulation by the CD28 family" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6582781220812182564" "False" "High" "IsMasterProtein" "Q9NX70" "Mediator of RNA polymerase II transcription subunit 29 OS=Homo sapiens OX=9606 GN=MED29 PE=1 SV=1" "0.004" "False" "3.181" "6" "1" "1" "1" "200" "21.1" "6.29" "3.07" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf11568" "55588" "ENSG00000063322" "MED29" "B4DNQ6; hsa:55588; M0R2E4; Q5XX09; Q9NTF4; Q9NX70" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "0.926" "0.969" "0.940" "1.126" "0.967" "1.050" "1.080" "0.873" "1.134" "74.6" "69.0" "72.3" "70.1" "84.0" "72.1" "78.3" "80.5" "65.1" "84.6" "" "" "" "" "" "" "" "" "" "" "67.0" "55.9" "65.4" "68.4" "69.3" "72.1" "58.6" "71.1" "58.2" "30.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1292459384444475416" "False" "High" "IsMasterProtein" "Q8N111" "Cell cycle exit and neuronal differentiation protein 1 OS=Homo sapiens OX=9606 GN=CEND1 PE=1 SV=1" "0.005" "False" "3.175" "6" "1" "1" "1" "149" "14.9" "9.20" "2.82" "1" "developmental processes;other biological processes" "other membranes" "" "Pf15677" "51286" "ENSG00000184524" "CEND1" "hsa:51286; Q8N111; Q9NYM6" "" "" "0" "0" "1.025" "1.107" "1.009" "0.947" "1.056" "1.018" "0.990" "0.846" "0.792" "165.3" "169.4" "183.0" "166.7" "156.5" "174.6" "168.3" "163.7" "139.9" "131.0" "" "" "" "" "" "" "" "" "" "" "148.7" "137.1" "165.5" "162.8" "129.2" "174.6" "126.0" "144.6" "125.2" "46.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-155447427223618220" "False" "High" "IsMasterProtein" "A6NFY7" "Succinate dehydrogenase assembly factor 1, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF1 PE=1 SV=1" "0.005" "False" "3.173" "14" "1" "3" "1" "115" "12.8" "11.39" "0.00" "1" "cell organization and biogenesis" "mitochondrion;nucleus" "" "Pf05347" "644096" "ENSG00000205138" "SDHAF1" "A6NFY7; B2RPM7; hsa:644096" "Mitochondrial complex II assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-8437965729251271503" "False" "High" "IsMasterProtein" "Q969P0" "Immunoglobulin superfamily member 8 OS=Homo sapiens OX=9606 GN=IGSF8 PE=1 SV=1" "0.005" "False" "3.165" "2" "1" "1" "1" "613" "65.0" "8.00" "3.68" "1" "developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf07686" "93185" "ENSG00000162729" "IGSF8" "hsa:93185; Q8NG09; Q969P0; Q96DP4; Q9BTG9" "11p11.2 copy number variation syndrome" "" "1" "0" "0.847" "0.876" "0.869" "1.018" "0.945" "0.968" "0.823" "0.837" "0.978" "124.8" "105.7" "109.3" "108.4" "127.1" "117.9" "120.8" "102.8" "104.5" "122.0" "" "" "" "" "" "" "" "" "" "" "112.2" "85.5" "98.9" "105.9" "104.8" "117.9" "90.5" "90.8" "93.5" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8284852689861497980" "False" "High" "IsMasterProtein" "Q5VV52" "Zinc finger protein 691 OS=Homo sapiens OX=9606 GN=ZNF691 PE=1 SV=2" "0.005" "False" "3.165" "5" "1" "3" "1" "315" "35.8" "7.80" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf13465" "51058" "ENSG00000164011" "ZNF691" "A8MXP6; B4DJR7; hsa:51058; O95878; Q5VV52; Q9NWE8" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5414288998537041680" "False" "High" "IsMasterProtein" "Q9UK53" "Inhibitor of growth protein 1 OS=Homo sapiens OX=9606 GN=ING1 PE=1 SV=2" "0.005" "False" "3.159" "2" "1" "1" "1" "422" "46.7" "9.06" "3.51" "1" "cell cycle OR cell proliferation;transport;other biological processes" "nucleus" "other molecular function" "Pf12998" "3621" "ENSG00000153487" "ING1" "hsa:3621; O00532; O43658; Q53ZR3; Q5T9G8; Q5T9G9; Q5T9H0; Q5T9H1; Q9H007; Q9HD98; Q9HD99; Q9NS83; Q9P0U6; Q9UBC6; Q9UIJ1; Q9UIJ2; Q9UIJ3; Q9UIJ4; Q9UK52; Q9UK53" "" "" "0" "0" "1.073" "1.000" "0.962" "0.925" "0.934" "0.961" "0.865" "0.875" "1.663" "161.0" "172.8" "161.0" "154.9" "148.9" "150.3" "154.7" "139.2" "140.8" "267.6" "" "" "" "" "" "" "" "" "" "" "144.7" "139.8" "145.6" "151.2" "122.9" "150.3" "115.8" "122.9" "126.0" "95.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "203506742472389879" "False" "High" "IsMasterProtein" "Q5RL73" "RNA-binding protein 48 OS=Homo sapiens OX=9606 GN=RBM48 PE=1 SV=1" "0.005" "False" "3.152" "3" "1" "1" "1" "367" "41.8" "8.72" "3.55" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity" "" "84060" "ENSG00000127993" "RBM48" "B7Z2K5; B7ZL51; hsa:84060; Q5H9T2; Q5RL73; Q8IYW7; Q96NS0; Q9H0V7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7502267447222380377" "False" "High" "IsMasterProtein" "O94844" "Rho-related BTB domain-containing protein 1 OS=Homo sapiens OX=9606 GN=RHOBTB1 PE=1 SV=2" "0.005" "False" "3.152" "2" "1" "2" "1" "696" "79.4" "6.87" "7.49" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;other cytoplasmic organelle" "other molecular function" "Pf00071, Pf00651" "9886" "ENSG00000072422" "RHOBTB1" "hsa:9886; O94844" "" "RHOBTB1 GTPase cycle" "1" "0" "0.830" "0.993" "0.510" "0.769" "0.650" "0.611" "0.719" "0.691" "0.567" "214.1" "177.7" "212.5" "109.2" "164.6" "139.0" "130.7" "154.0" "148.0" "121.3" "" "" "" "" "" "" "" "" "" "" "192.5" "143.8" "192.2" "106.6" "135.8" "139.0" "97.9" "136.0" "132.4" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2666601626281135846" "False" "High" "IsMasterProtein" "Q92551" "Inositol hexakisphosphate kinase 1 OS=Homo sapiens OX=9606 GN=IP6K1 PE=1 SV=3" "0.005" "False" "3.133" "2" "1" "1" "1" "441" "50.2" "7.24" "3.26" "1" "other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "9807" "ENSG00000176095" "IP6K1" "A8K157; A8MUX4; hsa:9807; Q7L3I7; Q92551; Q96E38" "" "Synthesis of pyrophosphates in the cytosol; Synthesis of IPs in the nucleus" "2" "0" "1.056" "1.091" "1.128" "0.832" "0.942" "1.178" "0.895" "1.251" "1.460" "32.4" "34.2" "35.3" "36.5" "26.9" "30.5" "38.2" "29.0" "40.5" "47.3" "" "" "" "" "" "" "" "" "" "" "29.1" "27.7" "32.0" "35.7" "22.2" "30.5" "28.6" "25.6" "36.2" "16.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6623340480838481175" "False" "High" "IsMasterProtein" "Q15287" "RNA-binding protein with serine-rich domain 1 OS=Homo sapiens OX=9606 GN=RNPS1 PE=1 SV=1" "0.005" "False" "3.132" "5" "1" "1" "1" "305" "34.2" "11.84" "2.45" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "10921" "ENSG00000205937" "RNPS1" "A8K1P0; B4DDU8; B4DZU7; B7ZA17; hsa:10921; O75308; Q15287; Q32P25; Q8WY42; Q9NYG3" "mRNA processing" "Transport of Mature mRNA derived from an Intron-Containing Transcript; Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); mRNA 3'-end processing; RNA Polymerase II Transcription Termination; mRNA Splicing - Major Pathway" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8300178027695563917" "False" "High" "IsMasterProtein" "P34059" "N-acetylgalactosamine-6-sulfatase OS=Homo sapiens OX=9606 GN=GALNS PE=1 SV=1" "0.005" "False" "3.129" "2" "1" "1" "1" "522" "58.0" "6.74" "3.48" "1" "" "non-structural extracellular;other cytoplasmic organelle" "other molecular function" "Pf00884, Pf14707" "2588" "ENSG00000141012" "GALNS" "hsa:2588; P34059; Q86VK3" "Glycosaminoglycan degradation" "Keratan sulfate degradation; Neutrophil degranulation; MPS IV - Morquio syndrome A" "4" "0" "0.971" "1.080" "0.966" "1.151" "1.147" "0.893" "1.097" "1.218" "1.059" "149.1" "144.9" "161.1" "144.1" "171.6" "171.0" "133.2" "163.6" "181.7" "157.9" "" "" "" "" "" "" "" "" "" "" "134.1" "117.2" "145.8" "140.7" "141.6" "171.0" "99.8" "144.5" "162.5" "56.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1333795596038477477" "False" "High" "IsMasterProtein" "P62877" "E3 ubiquitin-protein ligase RBX1 OS=Homo sapiens OX=9606 GN=RBX1 PE=1 SV=1" "0.005" "False" "3.118" "7" "1" "1" "1" "108" "12.3" "6.96" "3.62" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf12678" "9978" "ENSG00000100387" "RBX1" "B2RDY1; hsa:9978; P62877; Q8N6Z8; Q9D1S2; Q9WUK9; Q9Y254" "Cell cycle; Dual hijack model of Vif in HIV infection; TGF-beta signaling pathway; Type 2 papillary renal cell carcinoma; NRF2-ARE regulation; Hippo-Merlin signaling dysregulation; 22q11.2 copy number variation syndrome; Nucleotide excision repair; Hijack of ubiquitination by SARS-CoV-2; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 1p36 copy number variation syndrome" "Potential therapeutics for SARS; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Recognition of DNA damage by PCNA-containing replication complex; Dual Incision in GG-NER; Regulation of expression of SLITs and ROBOs; Antigen processing: Ubiquitination & Proteasome degradation; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; Vif-mediated degradation of APOBEC3G; Degradation of beta-catenin by the destruction complex; Degradation of DVL; Degradation of GLI1 by the proteasome; Degradation of GLI2 by the proteasome; GLI3 is processed to GLI3R by the proteasome; Hedgehog 'on' state; Regulation of RAS by GAPs; Orc1 removal from chromatin; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; Regulation of RUNX2 expression and activity; Neddylation; Interleukin-1 signaling; KEAP1-NFE2L2 pathway; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Negative regulation of NOTCH4 signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of BACH1 activity; NOTCH1 Intracellular Domain Regulates Transcription; Formation of TC-NER Pre-Incision Complex; Prolactin receptor signaling; Evasion by RSV of host interferon responses; DNA Damage Recognition in GG-NER; Nuclear events stimulated by ALK signaling in cancer; Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling" "48" "0" "0.852" "1.058" "0.829" "0.998" "0.898" "0.957" "1.005" "0.932" "0.778" "121.8" "103.8" "128.9" "101.1" "121.6" "109.4" "116.6" "122.5" "113.5" "94.8" "" "" "" "" "" "" "" "" "" "" "109.5" "84.0" "116.6" "98.6" "100.4" "109.4" "87.3" "108.2" "101.6" "33.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4730451351483933785" "False" "High" "IsMasterProtein" "O60496" "Docking protein 2 OS=Homo sapiens OX=9606 GN=DOK2 PE=1 SV=2" "0.005" "False" "3.117" "3" "1" "1" "1" "412" "45.4" "6.02" "2.72" "1" "signal transduction;other biological processes" "cytosol;other cell component" "signal transduction activity or receptor binding" "Pf02174" "9046" "ENSG00000147443" "DOK2" "hsa:9046; O60496; Q8N5A4" "RAC1/PAK1/p38/MMP2 pathway; IL-4 signaling pathway; EGF/EGFR signaling pathway" "RET signaling; Tie2 Signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4887773767884950166" "False" "High" "IsMasterProtein" "Q68DK7" "Male-specific lethal 1 homolog OS=Homo sapiens OX=9606 GN=MSL1 PE=1 SV=3" "0.005" "False" "3.117" "2" "1" "1" "1" "614" "67.1" "8.92" "3.33" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf15275, Pf16801" "339287" "ENSG00000188895" "MSL1" "hsa:339287; Q0VF46; Q68DK7; Q69Z03" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9106014466644302785" "False" "High" "IsMasterProtein" "Q9Y5Q8" "General transcription factor 3C polypeptide 5 OS=Homo sapiens OX=9606 GN=GTF3C5 PE=1 SV=2" "0.005" "False" "3.108" "2" "1" "1" "1" "519" "59.5" "6.90" "2.51" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf09734, Pf17682" "9328" "ENSG00000148308" "GTF3C5" "A6NI44; A6NJB9; hsa:9328; Q5T7U2; Q5T7U3; Q8N2U7; Q8N857; Q96GD9; Q9H4P2; Q9Y5Q8" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5982130504880554799" "False" "High" "IsMasterProtein" "O75394" "Large ribosomal subunit protein bL33m OS=Homo sapiens OX=9606 GN=MRPL33 PE=1 SV=1" "0.005" "False" "3.108" "17" "1" "1" "1" "65" "7.6" "10.80" "2.29" "1" "protein metabolism;other metabolic processes" "other membranes;mitochondrion;translational apparatus" "other molecular function" "Pf00471" "9553" "ENSG00000243147" "MRPL33" "hsa:9553; O75394; Q53RZ6; Q5FVE3; Q96Q50" "" "Mitochondrial translation initiation; Mitochondrial translation elongation; Mitochondrial translation termination" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1624029487017367107" "False" "High" "IsMasterProtein" "Q9C005" "Protein dpy-30 homolog OS=Homo sapiens OX=9606 GN=DPY30 PE=1 SV=1" "0.005" "False" "3.106" "9" "1" "1" "1" "99" "11.2" "4.88" "3.38" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;transport" "ER/Golgi;nucleus" "other molecular function" "Pf05186" "84661" "ENSG00000162961" "DPY30" "D6W578; hsa:84661; Q9C005" "Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4811963604537530771" "False" "High" "IsMasterProtein" "Q96S15" "GATOR2 complex protein WDR24 OS=Homo sapiens OX=9606 GN=WDR24 PE=1 SV=2" "0.005" "False" "3.103" "1" "1" "1" "1" "790" "88.2" "6.52" "2.75" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "84219" "ENSG00000127580" "WDR24" "A2IDB8; D3DU59; hsa:84219; Q96GC7; Q96S15; Q9H0B7" "" "Amino acids regulate mTORC1" "1" "0" "0.990" "1.043" "1.088" "1.125" "1.012" "1.072" "1.031" "1.001" "1.021" "97.4" "96.4" "101.6" "105.9" "109.6" "98.6" "104.4" "100.4" "97.5" "99.5" "" "" "" "" "" "" "" "" "" "" "87.6" "78.0" "91.9" "103.4" "90.4" "98.6" "78.2" "88.7" "87.2" "35.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6579369189662832735" "False" "High" "IsMasterProtein" "Q8IX04" "Ubiquitin-conjugating enzyme E2 variant 3 OS=Homo sapiens OX=9606 GN=UEVLD PE=1 SV=2" "0.005" "False" "3.102" "6" "2" "2" "2" "471" "52.2" "7.09" "4.94" "2" "protein metabolism;other metabolic processes;transport" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00056, Pf02866, Pf05743" "55293" "ENSG00000151116" "UEVLD" "B2RB69; B4DL43; F5H6L6; H7BYD6; hsa:55293; Q6P2F0; Q8IX04; Q96FF5; Q9NUX7" "" "" "0" "0" "0.917" "1.036" "1.088" "1.186" "0.840" "1.056" "0.798" "0.974" "1.024" "35.7" "32.8" "37.0" "38.9" "42.4" "30.0" "37.7" "28.5" "34.8" "36.6" "" "" "" "" "" "" "" "" "" "" "32.1" "26.5" "33.5" "37.9" "35.0" "30.0" "28.2" "25.2" "31.1" "13.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8745389805375581361" "False" "High" "IsMasterProtein" "P24539" "ATP synthase F(0) complex subunit B1, mitochondrial OS=Homo sapiens OX=9606 GN=ATP5PB PE=1 SV=2" "0.005" "False" "3.101" "3" "1" "1" "1" "256" "28.9" "9.36" "3.91" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "Pf05405" "515" "ENSG00000116459" "ATP5PB" "hsa:515; P24539; Q9BQ68; Q9BRU8" "Electron transport chain: OXPHOS system in mitochondria; 7q11.23 copy number variation syndrome; Oxidative phosphorylation" "Cristae formation; Formation of ATP by chemiosmotic coupling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8644531714570174079" "False" "High" "IsMasterProtein" "Q8WVM0" "Dimethyladenosine transferase 1, mitochondrial OS=Homo sapiens OX=9606 GN=TFB1M PE=1 SV=1" "0.005" "False" "3.092" "4" "1" "2" "1" "346" "39.5" "9.26" "3.55" "1" "RNA metabolism OR transcription;other metabolic processes" "mitochondrion" "nucleic acid binding activity;other molecular function" "Pf00398" "51106" "ENSG00000029639" "TFB1M" "hsa:51106; Q05DR0; Q8WVM0; Q9Y384" "Energy metabolism; Mitochondrial gene expression" "Transcriptional activation of mitochondrial biogenesis; rRNA modification in the mitochondrion" "4" "0" "0.965" "0.914" "0.811" "0.937" "0.901" "0.951" "0.873" "0.902" "0.787" "102.9" "99.3" "94.0" "83.4" "96.5" "92.7" "97.9" "89.9" "92.8" "81.0" "" "" "" "" "" "" "" "" "" "" "92.5" "80.3" "85.0" "81.5" "79.6" "92.7" "73.3" "79.4" "83.1" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8029509769443933574" "False" "High" "IsMasterProtein" "Q7Z7A3" "Cytoplasmic tRNA 2-thiolation protein 1 OS=Homo sapiens OX=9606 GN=CTU1 PE=1 SV=1" "0.005" "False" "3.087" "4" "1" "1" "1" "348" "36.4" "9.20" "3.79" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol" "nucleic acid binding activity;other molecular function" "Pf01171, Pf16503" "90353" "ENSG00000142544" "CTU1" "A8K558; hsa:90353; Q7Z7A3; Q96GZ7" "" "tRNA modification in the nucleus and cytosol" "1" "0" "0.932" "0.855" "1.160" "0.982" "0.879" "1.270" "1.024" "0.960" "1.048" "114.1" "106.4" "97.6" "132.4" "112.1" "100.4" "144.9" "116.9" "109.6" "119.6" "" "" "" "" "" "" "" "" "" "" "102.6" "86.1" "88.3" "129.3" "92.5" "100.4" "108.5" "103.3" "98.1" "42.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6208634135307330971" "False" "High" "IsMasterProtein" "P17480" "Nucleolar transcription factor 1 OS=Homo sapiens OX=9606 GN=UBTF PE=1 SV=1" "0.005" "False" "3.061" "1" "1" "1" "1" "764" "89.4" "5.81" "3.05" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00505, Pf09011, Pf14887" "7343" "ENSG00000108312" "UBTF" "A8K6R8; hsa:7343; P17480" "Ectoderm differentiation" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; RNA Polymerase I Promoter Opening" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3273725157349986493" "False" "High" "IsMasterProtein" "Q99698" "Lysosomal-trafficking regulator OS=Homo sapiens OX=9606 GN=LYST PE=1 SV=3" "0.005" "False" "3.044" "1" "2" "2" "2" "3801" "428.9" "6.61" "4.44" "2" "cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton" "other molecular function" "Pf00400, Pf02138, Pf14844" "1130" "ENSG00000143669" "LYST" "hsa:1130; O43274; Q5T2U9; Q96TD7; Q96TD8; Q99698; Q99709; Q9H133" "" "" "0" "0" "1.362" "1.247" "0.719" "2.363" "1.492" "1.011" "1.138" "0.963" "0.791" "44.2" "60.2" "55.1" "31.8" "104.5" "65.9" "44.7" "50.3" "42.6" "35.0" "" "" "" "" "" "" "" "" "" "" "39.7" "48.7" "49.9" "31.0" "86.2" "65.9" "33.5" "44.4" "38.1" "12.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4393204020125526762" "False" "High" "IsMasterProtein" "O75164" "Lysine-specific demethylase 4A OS=Homo sapiens OX=9606 GN=KDM4A PE=1 SV=2" "0.005" "False" "3.043" "1" "1" "1" "1" "1064" "120.6" "5.85" "3.40" "1" "cell organization and biogenesis;stress response;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02373, Pf02375, Pf13831, Pf13832, Pf18104" "9682" "ENSG00000066135" "KDM4A" "hsa:9682; O75164; Q5VVB1" "" "Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; HDMs demethylate histones; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3474294696230131597" "False" "High" "IsMasterProtein" "Q86WN1" "F-BAR and double SH3 domains protein 1 OS=Homo sapiens OX=9606 GN=FCHSD1 PE=1 SV=1" "0.005" "False" "3.042" "1" "1" "1" "1" "690" "76.9" "5.34" "3.12" "1" "cell-cell signaling;cell organization and biogenesis" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00611, Pf14604" "89848" "ENSG00000197948" "FCHSD1" "hsa:89848; Q6UX75; Q86WN1; Q86Y77; Q9NXX8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4903431523093654151" "False" "High" "IsMasterProtein" "A0A0B4J2F0" "Protein PIGBOS1 OS=Homo sapiens OX=9606 GN=PIGBOS1 PE=1 SV=1" "0.005" "False" "3.039" "19" "1" "1" "1" "54" "6.3" "8.50" "2.54" "1" "stress response;other biological processes" "other membranes;mitochondrion" "" "" "101928527" "ENSG00000225973" "PIGBOS1" "A0A0B4J2F0; hsa:101928527" "" "" "0" "0" "0.911" "0.868" "0.873" "0.878" "0.925" "0.898" "1.101" "0.947" "0.294" "75.5" "68.8" "65.6" "65.9" "66.3" "69.8" "67.8" "83.1" "71.5" "22.2" "" "" "" "" "" "" "" "" "" "" "67.9" "55.7" "59.3" "64.3" "54.7" "69.8" "50.8" "73.4" "64.0" "7.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377279648093334159" "False" "High" "IsMasterProtein" "Q9UEE5" "Serine/threonine-protein kinase 17A OS=Homo sapiens OX=9606 GN=STK17A PE=1 SV=2" "0.005" "False" "3.038" "2" "1" "1" "1" "414" "46.5" "5.15" "3.44" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;nucleus" "kinase activity;other molecular function" "Pf00069" "9263" "ENSG00000164543" "STK17A" "A4D1V6; hsa:9263; Q8IVC8; Q9UEE5" "" "" "0" "0" "1.186" "1.198" "0.988" "1.015" "1.122" "1.287" "1.233" "1.175" "2.035" "169.8" "201.5" "203.4" "167.7" "172.4" "190.6" "218.6" "209.5" "199.6" "345.5" "" "" "" "" "" "" "" "" "" "" "152.7" "163.0" "184.0" "163.7" "142.2" "190.6" "163.7" "185.0" "178.6" "123.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1753362023353680935" "False" "High" "IsMasterProtein" "Q8WY91" "Peroxynitrite isomerase THAP4 OS=Homo sapiens OX=9606 GN=THAP4 PE=1 SV=2" "0.005" "False" "3.023" "2" "1" "2" "1" "577" "62.9" "9.28" "2.87" "1" "other metabolic processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf05485, Pf08768" "51078" "ENSG00000176946" "THAP4" "hsa:51078; Q53NU7; Q6GRN0; Q6IPJ3; Q8WY91; Q9NW26; Q9Y325" "2q37 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8070932965104358622" "False" "High" "IsMasterProtein" "Q86YS7" "C2 domain-containing protein 5 OS=Homo sapiens OX=9606 GN=C2CD5 PE=1 SV=1" "0.005" "False" "3.019" "1" "1" "1" "1" "1000" "110.4" "5.69" "3.18" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00168" "9847" "ENSG00000111731" "C2CD5" "B4DJ03; B4DRN7; B7ZLL0; F5H2A1; F5H5R1; hsa:9847; O60280; Q17RY7; Q7Z619; Q86SU3; Q86YS7" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1613260033109497661" "False" "High" "IsMasterProtein" "Q17RY0" "Cytoplasmic polyadenylation element-binding protein 4 OS=Homo sapiens OX=9606 GN=CPEB4 PE=1 SV=1" "0.005" "False" "3.016" "2" "1" "1" "1" "729" "80.1" "7.18" "4.24" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "ER/Golgi;nucleus;other cell component" "translation activity;nucleic acid binding activity;other molecular function" "Pf16366, Pf16367" "80315" "ENSG00000113742" "CPEB4" "B7ZLQ7; hsa:80315; Q17RY0; Q7Z310; Q8N405; Q9C0J0" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "0.964" "1.057" "0.993" "1.013" "1.044" "1.026" "1.051" "0.951" "1.053" "195.3" "188.2" "206.4" "194.0" "197.8" "203.8" "200.4" "205.3" "185.8" "205.7" "" "" "" "" "" "" "" "" "" "" "175.6" "152.3" "186.7" "189.4" "163.2" "203.8" "150.0" "181.4" "166.3" "73.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7567103960318727217" "False" "High" "IsMasterProtein" "Q08999" "Retinoblastoma-like protein 2 OS=Homo sapiens OX=9606 GN=RBL2 PE=1 SV=3" "0.005" "False" "3.013" "1" "2" "2" "2" "1139" "128.3" "7.44" "4.63" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01857, Pf01858, Pf11934" "5934" "ENSG00000103479" "RBL2" "B7Z913; hsa:5934; Q08999; Q15073; Q16084; Q8NE70; Q92812" "Cell cycle; Thyroid stimulating hormone (TSH) signaling pathway; Adipogenesis; TGF-beta signaling pathway; PI3K-Akt signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ID signaling pathway; DNA damage response (only ATM dependent); Monoamine transport" "Cyclin D associated events in G1; FOXO-mediated transcription of cell cycle genes; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest; G1/S-Specific Transcription; Cyclin E associated events during G1/S transition ; Transcription of E2F targets under negative control by DREAM complex; Cyclin A:Cdk2-associated events at S phase entry; Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1" "18" "0" "0.878" "1.037" "0.963" "1.017" "0.971" "0.999" "0.983" "1.006" "1.072" "76.8" "67.5" "79.7" "74.0" "78.1" "74.6" "76.7" "75.5" "77.3" "82.4" "" "" "" "" "" "" "" "" "" "" "69.1" "54.6" "72.1" "72.2" "64.5" "74.6" "57.4" "66.7" "69.2" "29.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5797732752713602243" "False" "High" "IsMasterProtein" "Q15050" "Ribosome biogenesis regulatory protein homolog OS=Homo sapiens OX=9606 GN=RRS1 PE=1 SV=2" "0.005" "False" "3.006" "2" "1" "1" "1" "365" "41.2" "10.70" "3.46" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus;other cell component" "nucleic acid binding activity" "Pf04939" "23212" "ENSG00000179041" "RRS1" "hsa:23212; Q15050; Q9BUX8" "" "" "0" "0" "1.666" "1.130" "1.197" "1.526" "1.301" "1.382" "1.460" "1.408" "0.673" "71.7" "119.5" "81.1" "85.9" "109.5" "93.3" "99.1" "104.7" "101.0" "48.3" "" "" "" "" "" "" "" "" "" "" "64.5" "96.7" "73.3" "83.8" "90.4" "93.3" "74.2" "92.5" "90.4" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "44025785413676809" "False" "High" "IsMasterProtein" "A1L0T0" "2-hydroxyacyl-CoA lyase 2 OS=Homo sapiens OX=9606 GN=ILVBL PE=1 SV=2" "0.006" "False" "2.999" "2" "1" "1" "1" "632" "67.8" "8.15" "2.84" "1" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00205, Pf02775, Pf02776" "10994" "ENSG00000105135" "ILVBL" "A1L0T0; hsa:10994; O43341; Q96F08; Q99651; Q9BWN5; Q9UEB2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1789313073450950606" "False" "High" "IsMasterProtein" "Q9BSR8" "Protein YIPF4 OS=Homo sapiens OX=9606 GN=YIPF4 PE=1 SV=1" "0.006" "False" "2.998" "4" "1" "1" "1" "244" "27.1" "4.65" "3.14" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf04893" "84272" "ENSG00000119820" "YIPF4" "hsa:84272; Q9BSR8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5177067630619702561" "False" "High" "IsMasterProtein" "Q969S9" "Ribosome-releasing factor 2, mitochondrial OS=Homo sapiens OX=9606 GN=GFM2 PE=1 SV=1" "0.006" "False" "2.998" "2" "2" "2" "2" "779" "86.5" "6.51" "4.68" "2" "cell organization and biogenesis;protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf00009, Pf00679, Pf03144, Pf03764, Pf14492" "84340" "ENSG00000164347" "GFM2" "A0AR28; hsa:84340; Q8N6D8; Q8WYI0; Q969S9; Q9H6Z1" "" "Mitochondrial translation termination" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4826507384630182713" "False" "High" "IsMasterProtein" "Q96IZ7" "Serine/Arginine-related protein 53 OS=Homo sapiens OX=9606 GN=RSRC1 PE=1 SV=1" "0.006" "False" "2.993" "5" "1" "1" "1" "334" "38.7" "11.08" "1.71" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "nucleus;other cell component" "" "" "51319" "ENSG00000174891" "RSRC1" "A8K2R9; hsa:51319; Q96IZ7; Q96QK2; Q9NZE5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4354305271704446850" "False" "High" "IsMasterProtein" "O95248" "Myotubularin-related protein 5 OS=Homo sapiens OX=9606 GN=SBF1 PE=1 SV=4" "0.006" "False" "2.990" "1" "1" "1" "1" "1868" "208.3" "6.90" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00169, Pf02141, Pf02893, Pf03456, Pf06602, Pf12335" "6305" "ENSG00000100241" "SBF1" "A0A024R4Z9; A6PVG9; G5E933; hsa:6305; O60228; O95248; Q5JXD8; Q5PPM2; Q96GR9; Q9UGB8" "" "RAB GEFs exchange GTP for GDP on RABs; Synthesis of PIPs at the ER membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7807637693933670842" "False" "High" "IsMasterProtein" "Q8NB91" "Fanconi anemia group B protein OS=Homo sapiens OX=9606 GN=FANCB PE=1 SV=1" "0.006" "False" "2.985" "2" "2" "2" "2" "859" "97.7" "7.61" "2.17" "2" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "" "" "2187" "ENSG00000181544" "FANCB" "B2RMZ4; hsa:2187; Q7Z2U2; Q86XG1; Q8NB91" "DNA repair pathways, full network" "Fanconi Anemia Pathway; PKR-mediated signaling" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7040769112947432832" "False" "High" "IsMasterProtein" "Q96EY1" "DnaJ homolog subfamily A member 3, mitochondrial OS=Homo sapiens OX=9606 GN=DNAJA3 PE=1 SV=2" "0.006" "False" "2.985" "3" "1" "1" "1" "480" "52.5" "9.26" "4.12" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00226, Pf00684, Pf01556" "9093" "ENSG00000103423; ENSG00000276726" "DNAJA3" "B2RAJ5; B4DI33; E7ES32; hsa:9093; O75472; Q8WUJ6; Q8WXJ3; Q96D76; Q96EY1; Q96IV1; Q9NYH8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234172936871541887" "False" "High" "IsMasterProtein" "Q9HA65" "TBC1 domain family member 17 OS=Homo sapiens OX=9606 GN=TBC1D17 PE=1 SV=3" "0.006" "False" "2.985" "2" "1" "1" "1" "648" "72.6" "5.21" "3.70" "1" "other metabolic processes;transport" "cytosol;other cytoplasmic organelle" "enzyme regulator activity" "Pf00566, Pf12068" "79735" "ENSG00000104946" "TBC1D17" "B4DT12; B9A6L8; F5H1W7; hsa:79735; Q9HA65" "" "TBC/RABGAPs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8879076887959786971" "False" "High" "IsMasterProtein" "Q9P1Y6" "PHD and RING finger domain-containing protein 1 OS=Homo sapiens OX=9606 GN=PHRF1 PE=1 SV=3" "0.006" "False" "2.984" "1" "2" "2" "2" "1649" "178.6" "8.95" "4.88" "2" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00628, Pf13639" "57661" "ENSG00000070047; ENSG00000274780" "PHRF1" "A6H8W1; B7ZM64; B9EGP0; C9JS82; hsa:57661; Q6PJP2; Q8IVY2; Q8N2Y7; Q9BSM2; Q9P1Y6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4756905141364429020" "False" "High" "IsMasterProtein" "Q5BJF6" "Outer dense fiber protein 2 OS=Homo sapiens OX=9606 GN=ODF2 PE=1 SV=1" "0.006" "False" "2.983" "2" "2" "2" "2" "829" "95.3" "7.62" "2.37" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "" "4957" "ENSG00000136811" "ODF2" "B1AND3; B4DRK4; B4DX73; B4DZ02; E7EWL2; F5H6J4; hsa:4957; O14721; O60631; Q1W2J6; Q5BJF6; Q6UN26; Q7Z5I6; Q96FN2" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.061" "1.070" "0.985" "1.049" "1.004" "0.962" "1.025" "0.934" "1.103" "170.2" "180.6" "182.2" "167.7" "178.5" "170.9" "163.8" "174.5" "158.9" "187.7" "" "" "" "" "" "" "" "" "" "" "153.1" "146.1" "164.8" "163.7" "147.3" "170.9" "122.6" "154.1" "142.2" "67.0" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5139154873677700372" "False" "High" "IsMasterProtein" "Q9H9V9" "2-oxoglutarate and iron-dependent oxygenase JMJD4 OS=Homo sapiens OX=9606 GN=JMJD4 PE=1 SV=3" "0.006" "False" "2.982" "2" "1" "1" "1" "417" "47.4" "5.54" "3.70" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02373" "65094" "ENSG00000081692" "JMJD4" "A0A087WT84; hsa:65094; Q5TBZ1; Q5TBZ6; Q9H970; Q9H9V9" "" "Protein hydroxylation" "1" "0" "1.086" "1.043" "0.968" "1.025" "1.128" "1.137" "0.983" "1.086" "1.748" "85.4" "92.8" "89.2" "82.7" "87.6" "96.4" "97.2" "84.0" "92.8" "149.4" "" "" "" "" "" "" "" "" "" "" "76.8" "75.1" "80.6" "80.7" "72.3" "96.4" "72.8" "74.2" "83.0" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3097608289690062130" "False" "High" "IsMasterProtein" "P43250" "G protein-coupled receptor kinase 6 OS=Homo sapiens OX=9606 GN=GRK6 PE=1 SV=2" "0.006" "False" "2.982" "2" "1" "1" "1" "576" "65.9" "8.00" "3.19" "1" "cell-cell signaling;other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "2870" "ENSG00000198055" "GRK6" "hsa:2870; O60541; P43250; Q13652" "Follicle stimulating hormone (FSH) signaling pathway; Corticotropin-releasing hormone signaling pathway; Myometrial relaxation and contraction pathways; Chemokine signaling pathway; Calcium regulation in cardiac cells; 5q35 copy number variation" "G alpha (s) signalling events" "7" "0" "0.960" "1.032" "1.114" "0.989" "0.993" "1.034" "0.998" "1.006" "1.556" "96.0" "92.1" "99.0" "106.9" "94.9" "95.3" "99.3" "95.8" "96.5" "149.3" "" "" "" "" "" "" "" "" "" "" "86.3" "74.6" "89.6" "104.4" "78.4" "95.3" "74.3" "84.6" "86.4" "53.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-218313334757402260" "False" "High" "IsMasterProtein" "A6NFI3" "Zinc finger protein 316 OS=Homo sapiens OX=9606 GN=ZNF316 PE=1 SV=1" "0.006" "False" "2.978" "1" "1" "1" "1" "1004" "108.4" "5.31" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "100131017" "ENSG00000205903" "ZNF316" "A6NFI3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1908349325239483376" "False" "High" "IsMasterProtein" "H7BZ55" "Ciliary rootlet coiled-coil protein 2 OS=Homo sapiens OX=9606 GN=CROCC2 PE=1 SV=4" "0.006" "False" "2.976" "1" "2" "2" "1" "1653" "185.5" "5.50" "5.16" "2" "" "cytoskeleton" "" "Pf15035" "" "ENSG00000226321" "CROCC2" "H7BZ55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4905087365465039494" "False" "High" "IsMasterProtein" "Q9Y4Y9" "U6 snRNA-associated Sm-like protein LSm5 OS=Homo sapiens OX=9606 GN=LSM5 PE=1 SV=3" "0.006" "False" "2.974" "7" "1" "3" "1" "91" "9.9" "4.54" "7.02" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01423" "23658" "ENSG00000106355" "LSM5" "hsa:23658; Q9Y4Y9" "" "mRNA Splicing - Major Pathway; mRNA decay by 5' to 3' exoribonuclease" "2" "0" "0.897" "0.942" "0.938" "0.994" "0.875" "0.920" "0.993" "0.928" "0.683" "583.1" "523.2" "549.5" "547.0" "579.3" "510.0" "536.6" "578.7" "541.3" "398.0" "" "" "" "" "" "" "" "" "" "" "524.2" "423.4" "497.1" "533.9" "478.1" "510.0" "401.8" "511.2" "484.4" "142.1" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9045329245485250049" "False" "High" "IsMasterProtein" "Q9BW66" "Cyclin-dependent kinase 2-interacting protein OS=Homo sapiens OX=9606 GN=CINP PE=1 SV=1" "0.006" "False" "2.973" "5" "1" "1" "1" "212" "24.3" "6.28" "0.00" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "other molecular function" "" "51550" "ENSG00000100865" "CINP" "F5H7P3; F5H8A7; hsa:51550; Q9BW66; Q9NPF9" "" "" "0" "0" "0.855" "1.068" "1.005" "0.907" "0.894" "0.984" "1.044" "1.110" "0.759" "91.0" "77.8" "97.2" "91.5" "82.5" "81.3" "89.5" "95.0" "101.0" "69.1" "" "" "" "" "" "" "" "" "" "" "81.8" "62.9" "87.9" "89.3" "68.1" "81.3" "67.0" "84.0" "90.4" "24.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7097895090338821021" "False" "High" "IsMasterProtein" "Q8TDX9" "Polycystin-1-like protein 1 OS=Homo sapiens OX=9606 GN=PKD1L1 PE=1 SV=1" "0.006" "False" "2.968" "0" "2" "2" "1" "2849" "315.2" "7.06" "5.57" "2" "cell adhesion;transport;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00801, Pf01477, Pf02010, Pf08016, Pf20519" "168507" "ENSG00000158683" "PKD1L1" "Q6UWK1; Q8TDX9" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "0.854" "1.118" "0.742" "0.845" "0.790" "0.958" "0.922" "0.887" "0.620" "221.2" "189.0" "247.3" "164.1" "187.1" "174.8" "211.8" "203.9" "196.3" "137.2" "" "" "" "" "" "" "" "" "" "" "198.9" "152.9" "223.7" "160.2" "154.4" "174.8" "158.6" "180.1" "175.7" "49.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-898985269851167390" "False" "High" "IsMasterProtein" "Q96P53" "WD repeat and FYVE domain-containing protein 2 OS=Homo sapiens OX=9606 GN=WDFY2 PE=1 SV=2" "0.006" "False" "2.967" "4" "1" "1" "1" "400" "45.1" "6.93" "2.59" "1" "other biological processes" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf01363" "115825" "ENSG00000139668" "WDFY2" "B1AL86; hsa:115825; Q96CS1; Q96P53" "Mesodermal commitment pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4686055007853135805" "False" "High" "IsMasterProtein" "A6QL64" "Ankyrin repeat domain-containing protein 36A OS=Homo sapiens OX=9606 GN=ANKRD36 PE=1 SV=4" "0.006" "False" "2.965" "0" "1" "1" "1" "1915" "214.4" "8.70" "4.13" "1" "" "" "" "Pf12796, Pf14915" "375248" "ENSG00000135976; ENSG00000291582" "ANKRD36" "A0A494C0M0; A6QL64; B4E3I8; Q6UX02; Q86X62; Q9HCD1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6126928489973910912" "False" "High" "IsMasterProtein" "E9PKD4" "Nuclear pore complex-interacting protein family member A5 OS=Homo sapiens OX=9606 GN=NPIPA5 PE=2 SV=1" "0.006" "False" "2.961" "4" "1" "3" "1" "350" "40.1" "9.36" "7.40" "1" "" "" "" "Pf06409" "100288332" "ENSG00000183793" "NPIPA5" "E9PKD4; hsa:100288332; Q0P618" "" "" "0" "0" "0.962" "0.967" "0.908" "0.943" "0.828" "0.717" "0.886" "1.067" "0.829" "319.2" "307.0" "308.7" "289.8" "300.9" "264.3" "228.8" "282.7" "340.5" "264.6" "" "" "" "" "" "" "" "" "" "" "287.0" "248.4" "279.2" "282.9" "248.3" "264.3" "171.3" "249.7" "304.7" "94.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3008882847524475916" "False" "High" "IsMasterProtein" "Q15041" "ADP-ribosylation factor-like protein 6-interacting protein 1 OS=Homo sapiens OX=9606 GN=ARL6IP1 PE=1 SV=2" "0.006" "False" "2.956" "4" "1" "3" "1" "203" "23.3" "9.32" "6.56" "1" "cell organization and biogenesis;other biological processes" "other membranes;cytosol;ER/Golgi" "other molecular function" "" "23204" "ENSG00000170540" "ARL6IP1" "B7Z6S5; B7Z791; F5GXP4; hsa:23204; Q15041" "" "" "0" "0" "1.070" "1.004" "0.898" "1.045" "1.023" "1.029" "0.951" "0.990" "0.955" "285.8" "305.8" "286.9" "256.8" "298.6" "292.3" "294.2" "271.8" "283.0" "273.0" "" "" "" "" "" "" "" "" "" "" "257.0" "247.5" "259.5" "250.7" "246.4" "292.3" "220.3" "240.1" "253.2" "97.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3738159445275184604" "False" "High" "IsMasterProtein" "Q96SL4" "Glutathione peroxidase 7 OS=Homo sapiens OX=9606 GN=GPX7 PE=1 SV=1" "0.006" "False" "2.956" "4" "1" "2" "1" "187" "21.0" "8.27" "5.99" "1" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00255" "2882" "ENSG00000116157" "GPX7" "hsa:2882; O95337; Q5T501; Q96SL4" "Trans-sulfuration, one-carbon metabolism and related pathways; One-carbon metabolism and related pathways" "Detoxification of Reactive Oxygen Species" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "653544174487068262" "False" "High" "IsMasterProtein" "O00479" "High mobility group nucleosome-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=HMGN4 PE=1 SV=3" "0.006" "False" "2.952" "10" "1" "1" "1" "90" "9.5" "10.48" "4.59" "1" "cell organization and biogenesis" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "10473" "ENSG00000182952; ENSG00000292175" "HMGN4" "B2R4I6; hsa:10473; O00479; Q53XL9" "" "" "0" "0" "1.075" "1.192" "0.858" "1.013" "1.766" "1.034" "0.803" "1.052" "0.678" "171.4" "184.2" "204.2" "147.0" "173.6" "302.6" "177.1" "137.5" "180.2" "116.3" "" "" "" "" "" "" "" "" "" "" "154.1" "149.1" "184.7" "143.5" "143.2" "302.6" "132.6" "121.5" "161.3" "41.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5262953241339830264" "False" "High" "IsMasterProtein" "Q8WUH6" "Transmembrane protein 263 OS=Homo sapiens OX=9606 GN=TMEM263 PE=1 SV=1" "0.006" "False" "2.950" "13" "1" "1" "1" "116" "11.7" "9.32" "3.40" "1" "" "other membranes" "" "Pf15475" "90488" "ENSG00000151135" "TMEM263" "B3KMN9; hsa:90488; Q8WUH6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6000337729666772866" "False" "High" "IsMasterProtein" "Q9Y5Z9" "UbiA prenyltransferase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=UBIAD1 PE=1 SV=1" "0.006" "False" "2.945" "3" "1" "2" "1" "338" "36.8" "8.15" "4.48" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01040" "29914" "ENSG00000120942" "UBIAD1" "B3KQG3; hsa:29914; Q53GX3; Q5THD4; Q9Y5Z9" "7q11.23 copy number variation syndrome; Vitamin K metabolism and activation of dependent proteins" "Metabolism of vitamin K" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1719078157177780013" "False" "High" "IsMasterProtein" "Q96DX7" "Tripartite motif-containing protein 44 OS=Homo sapiens OX=9606 GN=TRIM44 PE=1 SV=1" "0.006" "False" "2.945" "3" "1" "1" "1" "344" "38.4" "4.21" "2.47" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "other molecular function" "Pf00643" "54765" "ENSG00000166326" "TRIM44" "D3DR14; Q96DX7; Q96QY2; Q9UGK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1254845465696571311" "False" "High" "IsMasterProtein" "Q9Y282" "Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Homo sapiens OX=9606 GN=ERGIC3 PE=1 SV=1" "0.006" "False" "2.941" "3" "1" "1" "1" "383" "43.2" "6.06" "3.01" "1" "transport;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf07970, Pf13850" "51614" "ENSG00000125991" "ERGIC3" "Q5JWS3; Q6ZWP7; Q9H276; Q9P1L3; Q9Y282" "" "" "0" "0" "0.864" "0.964" "0.774" "0.763" "0.822" "0.887" "0.776" "0.821" "0.617" "71.5" "61.7" "68.9" "55.3" "54.5" "58.8" "63.4" "55.5" "58.7" "44.1" "" "" "" "" "" "" "" "" "" "" "64.3" "50.0" "62.4" "54.0" "45.0" "58.8" "47.5" "49.0" "52.5" "15.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "357357949464127480" "False" "High" "IsMasterProtein" "O75503" "Bis(monoacylglycero)phosphate synthase CLN5 OS=Homo sapiens OX=9606 GN=CLN5 PE=1 SV=2" "0.006" "False" "2.939" "3" "1" "1" "1" "358" "41.5" "7.40" "2.89" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15014" "1203" "ENSG00000102805" "CLN5" "B3KQK7; hsa:1203; O75503" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2021793089049175464" "False" "High" "IsMasterProtein" "Q9HD67" "Unconventional myosin-X OS=Homo sapiens OX=9606 GN=MYO10 PE=1 SV=3" "0.006" "False" "2.938" "0" "1" "2" "1" "2058" "237.2" "6.21" "6.35" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00169, Pf00373, Pf00612, Pf00784, Pf00788, Pf16735, Pf18597" "4651" "ENSG00000145555" "MYO10" "A7E2D1; hsa:4651; O94893; Q8IVX5; Q9HD67; Q9NYM7; Q9P110; Q9P111; Q9UHF6" "" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; Netrin-1 signaling" "3" "0" "0.871" "0.756" "0.884" "0.868" "0.798" "0.964" "0.944" "0.840" "0.971" "127.1" "110.7" "96.1" "112.4" "110.4" "101.5" "122.6" "120.0" "106.8" "123.4" "" "" "" "" "" "" "" "" "" "" "114.3" "89.5" "86.9" "109.7" "91.1" "101.5" "91.8" "106.0" "95.5" "44.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3056902763191586994" "False" "High" "IsMasterProtein" "Q9NXJ5" "Pyroglutamyl-peptidase 1 OS=Homo sapiens OX=9606 GN=PGPEP1 PE=1 SV=1" "0.006" "False" "2.935" "4" "1" "1" "1" "209" "23.1" "5.90" "3.11" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf01470" "54858" "ENSG00000130517" "PGPEP1" "A8K1Q3; hsa:54858; Q8IVT1; Q9NXJ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7254766562605531244" "False" "High" "IsMasterProtein" "P62324" "Protein BTG1 OS=Homo sapiens OX=9606 GN=BTG1 PE=1 SV=1" "0.006" "False" "2.930" "6" "1" "1" "1" "171" "19.2" "8.18" "2.60" "1" "cell cycle OR cell proliferation;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf07742" "694" "ENSG00000133639" "BTG1" "hsa:694; P31607; P62324" "Exercise-induced circadian regulation" "FOXO-mediated transcription of cell cycle genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2558814197950096556" "False" "High" "IsMasterProtein" "Q9UKL3" "CASP8-associated protein 2 OS=Homo sapiens OX=9606 GN=CASP8AP2 PE=1 SV=1" "0.006" "False" "2.926" "1" "1" "1" "1" "1982" "222.5" "6.58" "0.00" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf21227" "9994" "ENSG00000288475" "CASP8AP2" "A2RUB7; E1P553; hsa:9994; Q6PH76; Q7LCQ7; Q86YD9; Q9NUQ4; Q9NZV9; Q9P2N1; Q9UKL3; Q9Y563" "" "SUMOylation of transcription cofactors" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "Not Found" "Not Found" "High" "High" "High" "Not Found" "Not Found" "1" "" "6863888683684881853" "False" "High" "IsMasterProtein" "Q9NZG7" "Ninjurin-2 OS=Homo sapiens OX=9606 GN=NINJ2 PE=1 SV=1" "0.006" "False" "2.924" "9" "1" "1" "1" "142" "15.7" "9.52" "2.77" "1" "cell adhesion;developmental processes;other biological processes" "plasma membrane;other membranes" "" "Pf04923" "4815" "ENSG00000171840" "NINJ2" "hsa:4815; Q9NZG7" "" "" "0" "0" "1.067" "0.881" "1.468" "1.005" "0.937" "1.115" "1.123" "1.230" "0.649" "58.5" "62.4" "51.5" "85.9" "58.8" "54.8" "65.2" "65.6" "71.9" "37.9" "" "" "" "" "" "" "" "" "" "" "52.6" "50.5" "46.6" "83.8" "48.5" "54.8" "48.8" "58.0" "64.4" "13.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6374027858147592096" "False" "High" "IsMasterProtein" "O95613" "Pericentrin OS=Homo sapiens OX=9606 GN=PCNT PE=1 SV=4" "0.006" "False" "2.921" "1" "2" "2" "2" "3336" "377.8" "5.55" "3.01" "2" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton" "other molecular function" "Pf10495" "5116" "ENSG00000160299" "PCNT" "hsa:5116; O43152; O95613; Q7Z7C9" "" "Late endosomal microautophagy; Recruitment of NuMA to mitotic centrosomes; Aggrephagy; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; Chaperone Mediated Autophagy" "10" "0" "1.153" "1.016" "0.847" "1.136" "1.086" "1.135" "0.991" "0.932" "1.114" "118.0" "136.1" "119.9" "100.0" "134.1" "128.1" "134.0" "116.9" "110.0" "131.4" "" "" "" "" "" "" "" "" "" "" "106.1" "110.1" "108.5" "97.6" "110.6" "128.1" "100.3" "103.3" "98.4" "46.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5889658442620060089" "False" "High" "IsMasterProtein" "Q9Y3V2" "RWD domain-containing protein 3 OS=Homo sapiens OX=9606 GN=RWDD3 PE=1 SV=4" "0.006" "False" "2.912" "3" "1" "1" "1" "267" "30.5" "6.18" "3.46" "1" "other biological processes" "nucleus;other cell component" "" "Pf05773" "25950" "ENSG00000122481" "RWDD3" "A6NP44; A8K9F0; C9J9L7; C9JI45; hsa:25950; Q08AJ7; Q6FID3; Q9BX35; Q9Y3V2" "" "SUMO is transferred from E1 to E2 (UBE2I, UBC9)" "1" "0" "1.014" "0.976" "0.993" "1.213" "1.160" "1.104" "1.077" "1.030" "1.137" "146.5" "148.5" "142.9" "145.4" "177.7" "170.0" "161.7" "157.8" "151.0" "166.6" "" "" "" "" "" "" "" "" "" "" "131.7" "120.2" "129.3" "142.0" "146.6" "170.0" "121.1" "139.4" "135.1" "59.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1415193059758406037" "False" "High" "IsMasterProtein" "Q9Y689" "ADP-ribosylation factor-like protein 5A OS=Homo sapiens OX=9606 GN=ARL5A PE=1 SV=1" "0.006" "False" "2.910" "4" "1" "1" "1" "179" "20.7" "6.79" "3.60" "1" "transport;other biological processes" "ER/Golgi" "other molecular function" "Pf00025" "26225" "ENSG00000162980" "ARL5A" "hsa:26225; Q580I5; Q9Y689" "" "" "0" "0" "1.106" "1.111" "0.938" "1.116" "1.025" "1.020" "0.902" "1.164" "1.583" "125.5" "138.8" "139.5" "117.8" "140.1" "128.7" "128.0" "113.3" "146.0" "198.7" "" "" "" "" "" "" "" "" "" "" "112.8" "112.3" "126.2" "115.0" "115.6" "128.7" "95.9" "100.0" "130.7" "70.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "157641750499335080" "False" "High" "IsMasterProtein" "Q9C0C7" "Activating molecule in BECN1-regulated autophagy protein 1 OS=Homo sapiens OX=9606 GN=AMBRA1 PE=1 SV=2" "0.006" "False" "2.909" "1" "1" "1" "1" "1298" "142.4" "7.18" "3.37" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400" "55626" "ENSG00000110497" "AMBRA1" "A6XN33; D3DQP8; G3V193; hsa:55626; Q86XD6; Q9C0C7; Q9H8Z0; Q9NXE7" "Alzheimer's disease and miRNA effects; Nanoparticle triggered autophagic cell death; Autophagy; Alzheimer's disease; Clock-controlled autophagy in bone metabolism" "Macroautophagy" "6" "0" "1.352" "1.030" "0.926" "1.440" "1.252" "1.073" "1.017" "1.240" "2.047" "15.0" "20.3" "15.5" "13.9" "21.6" "18.8" "16.1" "15.3" "18.6" "30.8" "" "" "" "" "" "" "" "" "" "" "13.5" "16.4" "14.0" "13.6" "17.9" "18.8" "12.1" "13.5" "16.7" "11.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3392290766648390097" "False" "High" "IsMasterProtein" "Q9UPP1" "Histone lysine demethylase PHF8 OS=Homo sapiens OX=9606 GN=PHF8 PE=1 SV=3" "0.006" "False" "2.904" "1" "1" "1" "1" "1060" "117.8" "8.72" "2.42" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "other membranes;nucleus" "other molecular function" "Pf00628, Pf02373, Pf17811" "23133" "ENSG00000172943" "PHF8" "B3KMV4; B7Z911; hsa:23133; Q5H9U5; Q5JPR9; Q5JPS0; Q5JPS2; Q5JPS3; Q5VUJ4; Q7Z6D4; Q9HAH2; Q9UPP1" "Ectoderm differentiation" "HDMs demethylate histones" "2" "0" "1.231" "0.816" "0.649" "0.927" "1.076" "0.909" "0.776" "0.564" "3.288" "15.5" "19.1" "12.7" "10.1" "14.4" "16.7" "14.1" "12.0" "8.7" "51.0" "" "" "" "" "" "" "" "" "" "" "13.9" "15.4" "11.4" "9.8" "11.9" "16.7" "10.6" "10.6" "7.8" "18.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4408499482478688157" "False" "High" "IsMasterProtein" "Q9Y4X4" "Krueppel-like factor 12 OS=Homo sapiens OX=9606 GN=KLF12 PE=1 SV=2" "0.006" "False" "2.901" "3" "1" "1" "1" "402" "44.2" "9.70" "3.30" "1" "other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "11278" "ENSG00000118922" "KLF12" "A8K5T2; hsa:11278; L0R3J4; Q5VZM7; Q9UHZ0; Q9Y4X4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8429437180713985689" "False" "High" "IsMasterProtein" "Q13761" "Runt-related transcription factor 3 OS=Homo sapiens OX=9606 GN=RUNX3 PE=1 SV=2" "0.006" "False" "2.901" "4" "2" "2" "2" "415" "44.3" "9.47" "5.96" "2" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00853, Pf08504" "864" "ENSG00000020633" "RUNX3" "B1AJV5; hsa:864; Q12969; Q13760; Q13761" "TYROBP causal network in microglia; Endochondral ossification; Endochondral ossification with skeletal dysplasias; TGF-beta receptor signaling in skeletal dysplasias; TGF-beta receptor signaling; Sudden infant death syndrome (SIDS) susceptibility pathways" "Regulation of RUNX3 expression and activity; RUNX3 regulates BCL2L11 (BIM) transcription; Binding of TCF/LEF:CTNNB1 to target gene promoters; RUNX3 regulates WNT signaling; RUNX3 regulates p14-ARF; RUNX3 regulates CDKN1A transcription; RUNX3 Regulates Immune Response and Cell Migration; RUNX3 regulates YAP1-mediated transcription; RUNX3 regulates NOTCH signaling; RUNX3 regulates RUNX1-mediated transcription" "16" "0" "1.020" "0.939" "1.041" "1.067" "0.966" "1.162" "0.943" "1.090" "1.468" "148.9" "151.9" "139.8" "155.0" "158.9" "143.8" "173.0" "140.4" "162.2" "218.6" "" "" "" "" "" "" "" "" "" "" "133.9" "122.9" "126.4" "151.3" "131.1" "143.8" "129.5" "124.0" "145.2" "78.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6773616667088229623" "False" "High" "IsMasterProtein" "Q8N4Q0" "Prostaglandin reductase 3 OS=Homo sapiens OX=9606 GN=PTGR3 PE=1 SV=1" "0.006" "False" "2.897" "4" "1" "1" "1" "377" "40.1" "8.18" "4.03" "1" "other metabolic processes;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf00107, Pf08240" "284273" "ENSG00000180011" "PTGR3" "A8KA15; B4DZ91; hsa:284273; Q8N4Q0" "" "" "0" "0" "1.405" "1.105" "1.183" "1.261" "1.210" "1.339" "1.088" "1.309" "1.226" "31.7" "44.5" "35.0" "37.5" "39.9" "38.3" "42.4" "34.5" "41.5" "38.8" "" "" "" "" "" "" "" "" "" "" "28.5" "36.0" "31.7" "36.6" "32.9" "38.3" "31.7" "30.4" "37.1" "13.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5978102986579792947" "False" "High" "IsMasterProtein" "Q69YL0" "Protein NCBP2AS2 OS=Homo sapiens OX=9606 GN=NCBP2AS2 PE=1 SV=1" "0.007" "False" "2.895" "8" "1" "1" "1" "99" "10.9" "12.00" "3.32" "1" "" "" "" "" "" "ENSG00000270170" "NCBP2AS2" "Q69YL0" "3q29 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2874212812822634582" "False" "High" "IsMasterProtein" "Q7Z3T8" "Zinc finger FYVE domain-containing protein 16 OS=Homo sapiens OX=9606 GN=ZFYVE16 PE=1 SV=3" "0.007" "False" "2.888" "1" "1" "1" "1" "1539" "168.8" "4.82" "1.75" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf11979" "9765" "ENSG00000039319" "ZFYVE16" "hsa:9765; O15023; Q5H9U2; Q7LAU7; Q7Z3T8; Q86T69; Q8N5L3; Q8NEK3" "TGF-beta signaling pathway" "Signaling by BMP" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2298234370805110889" "False" "High" "IsMasterProtein" "Q96DE9" "Protein EOLA2 OS=Homo sapiens OX=9606 GN=EOLA2 PE=2 SV=1" "0.007" "False" "2.885" "11" "1" "2" "1" "158" "17.8" "6.90" "6.61" "1" "" "" "" "" "541578" "ENSG00000197021" "EOLA2" "hsa:541578; Q96DE9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7926875629278284651" "False" "High" "IsMasterProtein" "Q9UKV5" "E3 ubiquitin-protein ligase AMFR OS=Homo sapiens OX=9606 GN=AMFR PE=1 SV=2" "0.007" "False" "2.873" "1" "1" "1" "1" "643" "72.9" "6.39" "3.01" "1" "cell-cell signaling;protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf02845, Pf13639, Pf18442" "267" "ENSG00000159461" "AMFR" "hsa:267; P26442; Q8IZ70; Q9UKV5" "Sterol regulatory element-binding proteins (SREBP) signaling" "ER Quality Control Compartment (ERQC); N-glycan trimming in the ER and Calnexin/Calreticulin cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4445461103723730342" "False" "High" "IsMasterProtein" "O43439" "Protein CBFA2T2 OS=Homo sapiens OX=9606 GN=CBFA2T2 PE=1 SV=1" "0.007" "False" "2.873" "2" "1" "1" "1" "604" "67.1" "8.05" "3.14" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf01753, Pf07531, Pf08788" "9139" "ENSG00000078699" "CBFA2T2" "B2RAE6; F8W6D7; hsa:9139; O43439; Q5TGE4; Q5TGE5; Q5TGE6; Q5TGE7; Q8IWF3; Q96B06; Q96L00; Q9H436; Q9UJP8; Q9UJP9; Q9UP24" "" "Specification of primordial germ cells" "1" "0" "1.052" "1.241" "1.577" "1.377" "1.117" "1.152" "1.198" "1.417" "1.559" "14.4" "15.2" "17.9" "22.7" "19.9" "16.1" "16.6" "17.3" "20.4" "22.5" "" "" "" "" "" "" "" "" "" "" "13.0" "12.3" "16.2" "22.2" "16.4" "16.1" "12.4" "15.3" "18.3" "8.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4245870540652335533" "False" "High" "IsMasterProtein" "Q8N8N7" "Prostaglandin reductase 2 OS=Homo sapiens OX=9606 GN=PTGR2 PE=1 SV=1" "0.007" "False" "2.873" "2" "1" "1" "1" "351" "38.5" "5.41" "3.24" "1" "other metabolic processes" "other cell component" "other molecular function" "Pf00107, Pf16884" "145482" "ENSG00000140043" "PTGR2" "hsa:145482; Q3L8A4; Q6MZH8; Q8N8N7" "Eicosanoid metabolism via cyclooxygenases (COX); Eicosanoid metabolism via lipooxygenases (LOX); Omega-6-fatty acids in senescence" "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5217952952055268548" "False" "High" "IsMasterProtein" "P49207" "Large ribosomal subunit protein eL34 OS=Homo sapiens OX=9606 GN=RPL34 PE=1 SV=3" "0.007" "False" "2.872" "14" "2" "2" "2" "117" "13.3" "11.47" "5.48" "2" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01199" "6164" "ENSG00000109475" "RPL34" "hsa:6164; P49207; Q6FG66; Q9BUZ2" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "0.679" "0.722" "0.813" "0.905" "0.815" "0.686" "0.727" "0.871" "1.006" "54.8" "37.2" "39.5" "44.5" "49.6" "44.6" "37.6" "39.8" "47.7" "55.1" "" "" "" "" "" "" "" "" "" "" "49.2" "30.1" "35.7" "43.5" "40.9" "44.6" "28.1" "35.2" "42.7" "19.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2668394544474588816" "False" "High" "IsMasterProtein" "Q99470" "Stromal cell-derived factor 2 OS=Homo sapiens OX=9606 GN=SDF2 PE=1 SV=2" "0.007" "False" "2.859" "11" "1" "1" "1" "211" "23.0" "7.33" "1.79" "1" "protein metabolism;other metabolic processes" "ER/Golgi;other cell component" "other molecular function" "Pf02815" "6388" "ENSG00000132581" "SDF2" "hsa:6388; Q99470; Q9BQ79" "" "" "0" "0" "1.002" "0.830" "0.996" "0.854" "0.765" "0.870" "0.929" "0.856" "0.710" "357.4" "358.0" "296.7" "356.1" "305.2" "273.5" "311.1" "332.0" "306.1" "253.6" "" "" "" "" "" "" "" "" "" "" "321.4" "289.7" "268.4" "347.6" "251.9" "273.5" "233.0" "293.2" "273.9" "90.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2134905287649132421" "False" "High" "IsMasterProtein" "Q9Y312" "Protein AAR2 homolog OS=Homo sapiens OX=9606 GN=AAR2 PE=1 SV=2" "0.007" "False" "2.856" "5" "1" "1" "1" "384" "43.4" "5.96" "3.24" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf05282, Pf20981" "25980" "ENSG00000131043" "AAR2" "E1P5S7; hsa:25980; Q9H4F9; Q9P1P3; Q9UFK9; Q9Y312" "Ciliary landscape" "" "1" "0" "0.706" "0.680" "0.849" "0.797" "0.878" "0.838" "0.947" "0.853" "0.339" "26.6" "18.8" "18.1" "22.6" "21.2" "23.4" "22.3" "25.2" "22.7" "9.0" "" "" "" "" "" "" "" "" "" "" "23.9" "15.2" "16.4" "22.0" "17.5" "23.4" "16.7" "22.3" "20.3" "3.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7975170816643306332" "False" "High" "IsMasterProtein" "O43543" "DNA repair protein XRCC2 OS=Homo sapiens OX=9606 GN=XRCC2 PE=1 SV=1" "0.007" "False" "2.854" "3" "1" "1" "1" "280" "31.9" "6.04" "3.13" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf08423" "7516" "ENSG00000196584" "XRCC2" "B2R925; hsa:7516; O43543" "Male infertility; Primary ovarian insufficiency" "Resolution of D-loop Structures through Holliday Junction Intermediates; Presynaptic phase of homologous DNA pairing and strand exchange; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5818593354028515611" "False" "High" "IsMasterProtein" "P56524" "Histone deacetylase 4 OS=Homo sapiens OX=9606 GN=HDAC4 PE=1 SV=3" "0.007" "False" "2.853" "1" "1" "1" "1" "1084" "119.0" "6.96" "2.81" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00850, Pf12203" "9759" "ENSG00000068024" "HDAC4" "E9PGB9; F5GX36; hsa:9759; P56524; Q86YH7; Q9UND6" "MicroRNAs in cardiomyocyte hypertrophy; Genes targeted by miRNAs in adipocytes; Neural crest differentiation; Cardiac hypertrophic response; Initiation of transcription and translation elongation at the HIV-1 LTR; ATM signaling in development and disease ; VEGFA-VEGFR2 signaling; Ethanol effects on histone modifications; Endochondral ossification; Endochondral ossification with skeletal dysplasias; CAMKK2 pathway; 2q37 copy number variation syndrome" "SUMOylation of chromatin organization proteins; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; SUMOylation of intracellular receptors; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; RUNX3 regulates p14-ARF; RUNX2 regulates chondrocyte maturation" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3944939482947776682" "False" "High" "IsMasterProtein" "P00480" "Ornithine transcarbamylase, mitochondrial OS=Homo sapiens OX=9606 GN=OTC PE=1 SV=3" "0.007" "False" "2.852" "2" "1" "2" "1" "354" "39.9" "8.63" "7.08" "1" "other metabolic processes;developmental processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00185, Pf02729" "5009" "ENSG00000036473" "OTC" "A8K9P2; D3DWB0; hsa:5009; P00480; Q3KNR1; Q6B0I1; Q9NYJ5" "Amino acid metabolism" "Mitochondrial protein import; Urea cycle" "3" "0" "1.083" "0.848" "0.782" "1.036" "0.783" "0.946" "0.942" "0.988" "0.663" "400.9" "434.1" "339.8" "313.4" "415.2" "313.9" "379.3" "377.5" "395.9" "266.0" "" "" "" "" "" "" "" "" "" "" "360.4" "351.3" "307.3" "305.9" "342.7" "313.9" "284.0" "333.4" "354.3" "94.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7316364973511523624" "False" "High" "IsMasterProtein" "Q8IYI6" "Exocyst complex component 8 OS=Homo sapiens OX=9606 GN=EXOC8 PE=1 SV=2" "0.007" "False" "2.850" "2" "1" "1" "1" "725" "81.7" "5.49" "2.59" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf08700, Pf16528" "149371" "ENSG00000116903" "EXOC8" "B3KU33; hsa:149371; Q5TE82; Q8IYI6" "RalA downstream regulated genes; Ciliary landscape" "Translocation of SLC2A4 (GLUT4) to the plasma membrane; Insulin processing; VxPx cargo-targeting to cilium" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1455362657326634232" "False" "High" "IsMasterProtein" "Q02543" "Large ribosomal subunit protein eL20 OS=Homo sapiens OX=9606 GN=RPL18A PE=1 SV=2" "0.007" "False" "2.848" "5" "1" "1" "1" "176" "20.7" "10.71" "2.51" "1" "protein metabolism;other metabolic processes" "cytosol;translational apparatus;other cell component" "other molecular function" "Pf01775" "6142" "ENSG00000105640" "RPL18A" "hsa:6142; Q02543" "VEGFA-VEGFR2 signaling; Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4369587105980304302" "False" "High" "IsMasterProtein" "P08F94" "Fibrocystin OS=Homo sapiens OX=9606 GN=PKHD1 PE=1 SV=1" "0.007" "False" "2.846" "1" "2" "2" "2" "4074" "446.4" "6.57" "0.00" "2" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf01833, Pf10162, Pf13229" "5314" "ENSG00000170927" "PKHD1" "hsa:5314; P08F94; Q5VUA2; Q5VUA3; Q5VWV1; Q86Z26; Q8TCZ9" "Ciliopathies; Bardet-Biedl syndrome" "" "2" "0" "1.573" "1.715" "1.831" "1.333" "1.510" "2.047" "1.011" "1.276" "6.712" "10.5" "16.4" "17.9" "19.1" "13.9" "15.8" "21.4" "10.6" "13.3" "70.2" "" "" "" "" "" "" "" "" "" "" "9.4" "13.3" "16.2" "18.7" "11.5" "15.8" "16.0" "9.3" "11.9" "25.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-586751030658289178" "False" "High" "IsMasterProtein" "Q9NZ53" "Podocalyxin-like protein 2 OS=Homo sapiens OX=9606 GN=PODXL2 PE=1 SV=1" "0.007" "False" "2.842" "1" "1" "1" "1" "605" "65.0" "4.34" "3.54" "1" "cell adhesion" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf06365" "50512" "ENSG00000114631" "PODXL2" "hsa:50512; Q6UVY4; Q8WUV6; Q9NZ53" "" "Cytosolic sulfonation of small molecules" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1011686902353610677" "False" "High" "IsMasterProtein" "Q8NBI5" "Equilibrative nucleobase transporter 1 OS=Homo sapiens OX=9606 GN=SLC43A3 PE=1 SV=2" "0.007" "False" "2.833" "2" "1" "1" "1" "491" "54.5" "8.53" "2.90" "1" "transport" "plasma membrane;other membranes" "transporter activity" "" "29015" "ENSG00000134802" "SLC43A3" "B4DNR8; E7EQD2; hsa:29015; Q8NBI5; Q9NSS4" "" "" "0" "0" "1.063" "0.909" "1.013" "0.934" "0.917" "1.057" "1.011" "1.066" "0.648" "74.7" "79.3" "67.9" "75.6" "69.7" "68.5" "78.9" "75.5" "79.6" "48.4" "" "" "" "" "" "" "" "" "" "" "67.1" "64.2" "61.4" "73.8" "57.5" "68.5" "59.1" "66.7" "71.2" "17.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4282348834355935328" "False" "High" "IsMasterProtein" "Q8IWW6" "Rho GTPase-activating protein 12 OS=Homo sapiens OX=9606 GN=ARHGAP12 PE=1 SV=1" "0.007" "False" "2.832" "3" "2" "2" "2" "846" "96.2" "7.61" "2.60" "2" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other cell component" "enzyme regulator activity" "Pf00018, Pf00169, Pf00397, Pf00620, Pf16618" "94134" "ENSG00000165322" "ARHGAP12" "B1ANY0; B1ANY1; B1ANY2; hsa:94134; Q504X1; Q86UB3; Q8IWW6; Q8IWW7; Q8N3L1; Q9NT76" "" "RAC1 GTPase cycle; RHOD GTPase cycle; RHOF GTPase cycle; RHOV GTPase cycle" "4" "0" "1.033" "1.065" "0.995" "1.137" "1.068" "1.130" "1.113" "1.080" "1.189" "189.3" "195.5" "201.6" "188.4" "215.1" "202.2" "213.9" "210.6" "204.4" "225.1" "" "" "" "" "" "" "" "" "" "" "170.2" "158.2" "182.3" "183.9" "177.5" "202.2" "160.2" "186.0" "182.9" "80.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3525614426972172152" "False" "High" "IsMasterProtein" "Q96JN0" "Ligand-dependent corepressor OS=Homo sapiens OX=9606 GN=LCOR PE=1 SV=2" "0.007" "False" "2.829" "3" "1" "1" "1" "433" "47.0" "9.38" "2.18" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf05225" "84458" "ENSG00000196233" "LCOR" "D3DR47; hsa:84458; Q5VW16; Q7Z723; Q86T32; Q86T33; Q8N3L6; Q8N655; Q96JN0; Q9H945; Q9Y457" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3173150073598587097" "False" "High" "IsMasterProtein" "O15259" "Nephrocystin-1 OS=Homo sapiens OX=9606 GN=NPHP1 PE=1 SV=1" "0.007" "False" "2.829" "1" "2" "2" "2" "732" "83.2" "5.20" "3.74" "2" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00018" "4867" "ENSG00000144061" "NPHP1" "hsa:4867; O14837; O15259" "Joubert syndrome; Ciliopathies; NPHP1 deletion syndrome" "Anchoring of the basal body to the plasma membrane" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2559725886688787495" "False" "High" "IsMasterProtein" "Q8WYP3" "Ras and Rab interactor 2 OS=Homo sapiens OX=9606 GN=RIN2 PE=1 SV=1" "0.007" "False" "2.827" "1" "1" "3" "1" "895" "100.1" "6.58" "6.16" "1" "transport;signal transduction;other biological processes" "cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00788, Pf02204" "54453" "ENSG00000132669" "RIN2" "hsa:54453; Q00425; Q5TFT8; Q8WYP3; Q9BQL3; Q9H071" "" "RAB GEFs exchange GTP for GDP on RABs" "1" "0" "0.790" "0.767" "0.985" "0.865" "0.721" "1.025" "1.013" "0.755" "0.746" "438.1" "346.2" "336.2" "431.8" "378.8" "315.7" "449.0" "443.8" "330.9" "326.8" "" "" "" "" "" "" "" "" "" "" "393.9" "280.1" "304.1" "421.5" "312.6" "315.7" "336.2" "392.0" "296.1" "116.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8329541297808121166" "False" "High" "IsMasterProtein" "P49848" "Transcription initiation factor TFIID subunit 6 OS=Homo sapiens OX=9606 GN=TAF6 PE=1 SV=1" "0.007" "False" "2.825" "3" "2" "2" "2" "677" "72.6" "8.60" "2.31" "2" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "6878" "ENSG00000106290" "TAF6" "A4D2B2; A4D2B3; B4DT11; D6W5U2; hsa:6878; P49848; Q6AI29" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; RNA polymerase II transcribes snRNA genes; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation" "11" "0" "0.992" "1.155" "1.074" "1.284" "1.041" "1.096" "0.943" "1.027" "1.266" "32.6" "32.4" "37.7" "35.0" "41.9" "34.0" "35.8" "30.8" "33.5" "41.3" "" "" "" "" "" "" "" "" "" "" "29.3" "26.2" "34.1" "34.2" "34.6" "34.0" "26.8" "27.2" "30.0" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7142901860351875660" "False" "High" "IsMasterProtein" "Q8WXE0" "Caskin-2 OS=Homo sapiens OX=9606 GN=CASKIN2 PE=1 SV=2" "0.007" "False" "2.822" "1" "2" "3" "1" "1202" "126.7" "7.09" "6.79" "2" "" "other cell component" "" "Pf00536, Pf07653, Pf12796, Pf16600, Pf16632, Pf16907" "57513" "ENSG00000177303" "CASKIN2" "B4DTT3; B7Z9H1; hsa:57513; Q7LG69; Q8WXE0; Q9ULT1" "" "" "0" "0" "0.988" "0.899" "0.735" "0.895" "0.996" "0.941" "0.830" "1.061" "0.856" "100.8" "99.6" "90.6" "74.1" "90.2" "100.3" "94.8" "83.6" "106.9" "86.2" "" "" "" "" "" "" "" "" "" "" "90.6" "80.6" "82.0" "72.3" "74.4" "100.3" "71.0" "73.9" "95.7" "30.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7909603471791156490" "False" "High" "IsMasterProtein" "Q86WK7" "Amphoterin-induced protein 3 OS=Homo sapiens OX=9606 GN=AMIGO3 PE=1 SV=1" "0.007" "False" "2.820" "3" "1" "3" "1" "504" "55.2" "7.87" "6.98" "1" "cell adhesion;developmental processes;other biological processes" "other membranes" "other molecular function" "Pf13855" "386724" "ENSG00000176020" "AMIGO3" "hsa:386724; Q494V6; Q86WK7; Q96JH6" "" "" "0" "0" "1.156" "1.080" "1.090" "1.229" "1.105" "1.218" "0.999" "1.243" "0.874" "157.5" "182.1" "170.2" "171.7" "193.6" "174.1" "191.9" "157.4" "195.8" "137.7" "" "" "" "" "" "" "" "" "" "" "141.6" "147.3" "153.9" "167.6" "159.7" "174.1" "143.7" "139.0" "175.2" "49.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5586512923677316661" "False" "High" "IsMasterProtein" "Q8N3J5" "Protein phosphatase Mn(2+)-dependent 1K OS=Homo sapiens OX=9606 GN=PPM1K PE=1 SV=1" "0.007" "False" "2.818" "3" "1" "1" "1" "372" "41.0" "6.74" "2.83" "1" "cell organization and biogenesis;other metabolic processes;transport" "mitochondrion" "other molecular function" "Pf00481" "152926" "ENSG00000163644" "PPM1K" "B2RAZ1; hsa:152926; Q05CT5; Q49AB5; Q4W5E6; Q56AN8; Q8IUZ7; Q8IXG7; Q8N3J5; Q8ND70; Q96NT4" "" "Branched-chain amino acid catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7262734157985051002" "False" "High" "IsMasterProtein" "Q9H7H0" "Ribosome assembly protein METTL17, mitochondrial OS=Homo sapiens OX=9606 GN=METTL17 PE=1 SV=1" "0.007" "False" "2.818" "2" "1" "1" "1" "456" "50.7" "9.33" "2.23" "1" "protein metabolism;other metabolic processes;other biological processes" "mitochondrion;nucleus" "other molecular function" "Pf09243" "64745" "ENSG00000165792" "METTL17" "hsa:64745; Q9BSH1; Q9BZH2; Q9BZH3; Q9H7H0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7766499346682965111" "False" "High" "IsMasterProtein" "Q99583" "Max-binding protein MNT OS=Homo sapiens OX=9606 GN=MNT PE=1 SV=1" "0.007" "False" "2.811" "1" "1" "1" "1" "582" "62.3" "8.78" "2.79" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "4335" "ENSG00000070444" "MNT" "A8K6D1; D3DTI7; hsa:4335; Q1ED38; Q99583" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2814328454838082789" "False" "High" "IsMasterProtein" "Q6P087" "Mitochondrial mRNA pseudouridine synthase RPUSD3 OS=Homo sapiens OX=9606 GN=RPUSD3 PE=1 SV=3" "0.007" "False" "2.809" "2" "1" "1" "1" "351" "38.4" "10.32" "3.17" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00849" "285367" "ENSG00000156990" "RPUSD3" "B4DS39; hsa:285367; Q6P087; Q6P6A9; Q8N1B2; Q8NAV3" "" "" "0" "0" "0.923" "1.061" "1.053" "1.066" "0.929" "1.158" "0.969" "0.797" "0.878" "180.5" "166.7" "191.4" "190.0" "192.3" "167.7" "209.0" "174.9" "143.9" "158.4" "" "" "" "" "" "" "" "" "" "" "162.3" "134.9" "173.1" "185.4" "158.7" "167.7" "156.5" "154.5" "128.7" "56.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-998134309870178967" "False" "High" "IsMasterProtein" "P47974" "mRNA decay activator protein ZFP36L2 OS=Homo sapiens OX=9606 GN=ZFP36L2 PE=1 SV=3" "0.007" "False" "2.801" "3" "1" "1" "1" "494" "51.0" "8.16" "3.56" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "678" "ENSG00000152518" "ZFP36L2" "hsa:678; P47974; Q53TB4; Q9BSJ3" "Pre-implantation embryo; TYROBP causal network in microglia" "M-decay: degradation of maternal mRNAs by maternally stored factors" "3" "0" "1.035" "1.019" "1.046" "0.843" "1.121" "1.128" "1.150" "0.901" "1.442" "33.4" "34.6" "34.0" "34.9" "28.2" "37.5" "37.7" "38.4" "30.1" "48.2" "" "" "" "" "" "" "" "" "" "" "30.0" "28.0" "30.8" "34.1" "23.3" "37.5" "28.2" "33.9" "26.9" "17.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2751730392985219929" "False" "High" "IsMasterProtein" "P09669" "Cytochrome c oxidase subunit 6C OS=Homo sapiens OX=9606 GN=COX6C PE=1 SV=2" "0.007" "False" "2.799" "11" "1" "1" "1" "75" "8.8" "10.39" "3.92" "1" "other metabolic processes" "other membranes;mitochondrion" "" "Pf02937" "1345" "ENSG00000164919" "COX6C" "B2R4D7; hsa:1345; P09669" "Electron transport chain: OXPHOS system in mitochondria; Ciliary landscape; Nonalcoholic fatty liver disease; Mitochondrial complex IV assembly; 5q35 copy number variation" "Respiratory electron transport; TP53 Regulates Metabolic Genes; Cytoprotection by HMOX1" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4356838441646261040" "False" "High" "IsMasterProtein" "Q96ST8" "Centrosomal protein of 89 kDa OS=Homo sapiens OX=9606 GN=CEP89 PE=1 SV=3" "0.007" "False" "2.794" "2" "2" "2" "2" "783" "89.5" "6.80" "3.63" "2" "cell-cell signaling;cell organization and biogenesis" "cytosol;cytoskeleton;mitochondrion;other cell component" "" "" "84902" "ENSG00000121289" "CEP89" "B9EGA6; hsa:84902; Q8N5J8; Q96ST8" "" "Anchoring of the basal body to the plasma membrane" "1" "0" "1.047" "1.053" "0.943" "1.037" "0.778" "1.120" "0.972" "1.019" "0.705" "217.9" "228.3" "229.5" "205.4" "226.0" "169.5" "244.2" "211.7" "222.1" "153.5" "" "" "" "" "" "" "" "" "" "" "195.9" "184.7" "207.5" "200.5" "186.5" "169.5" "182.8" "187.0" "198.8" "54.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5874507189654450183" "False" "High" "IsMasterProtein" "P50542" "Peroxisomal targeting signal 1 receptor OS=Homo sapiens OX=9606 GN=PEX5 PE=1 SV=3" "0.007" "False" "2.791" "1" "1" "1" "1" "639" "70.8" "4.54" "3.21" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf13181" "5830" "ENSG00000139197; ENSG00000288217" "PEX5" "A8K891; B4DZ45; B7ZAD5; D3DUT8; hsa:5830; P50542; Q15115; Q15266; Q96FN7" "1p36 copy number variation syndrome" "Pexophagy" "2" "0" "0.989" "1.210" "0.948" "1.021" "1.007" "1.027" "0.988" "1.170" "2.446" "124.1" "122.7" "150.2" "117.6" "126.7" "125.0" "127.5" "122.7" "145.2" "303.5" "" "" "" "" "" "" "" "" "" "" "111.6" "99.3" "135.8" "114.8" "104.6" "125.0" "95.5" "108.3" "129.9" "108.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5243679290783972836" "False" "High" "IsMasterProtein" "Q5JPE7" "BOS complex subunit NOMO2 OS=Homo sapiens OX=9606 GN=NOMO2 PE=1 SV=1" "0.007" "False" "2.789" "1" "1" "1" "1" "1267" "139.4" "5.76" "2.47" "1" "cell organization and biogenesis" "other membranes;cytosol;ER/Golgi;other cell component" "translation activity;other molecular function" "Pf13620, Pf17802" "283820" "ENSG00000185164" "NOMO2" "hsa:283820; Q4G177; Q5JPE7" "" "" "0" "0" "1.035" "1.105" "0.874" "1.198" "1.083" "0.972" "1.133" "1.110" "1.301" "50.1" "51.9" "55.4" "43.8" "60.0" "54.3" "48.7" "56.8" "55.6" "65.2" "" "" "" "" "" "" "" "" "" "" "45.1" "42.0" "50.1" "42.8" "49.5" "54.3" "36.5" "50.1" "49.8" "23.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8529217331400882174" "False" "High" "IsMasterProtein" "Q8TC05" "Nuclear protein MDM1 OS=Homo sapiens OX=9606 GN=MDM1 PE=1 SV=2" "0.007" "False" "2.786" "2" "1" "1" "1" "714" "80.7" "9.11" "3.51" "1" "developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf15501" "56890" "ENSG00000111554" "MDM1" "B4DM65; E7EPQ3; hsa:56890; O43406; Q8TC05; Q8WTV9; Q9NR04" "" "" "0" "0" "0.978" "1.128" "0.922" "0.935" "1.191" "1.101" "1.026" "1.100" "0.661" "48.5" "47.4" "54.6" "44.7" "45.3" "57.7" "53.4" "49.7" "53.3" "32.0" "" "" "" "" "" "" "" "" "" "" "43.6" "38.3" "49.4" "43.6" "37.4" "57.7" "39.9" "43.9" "47.7" "11.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9158641874839162528" "False" "High" "IsMasterProtein" "Q5JYT7" "Uncharacterized protein KIAA1755 OS=Homo sapiens OX=9606 GN=KIAA1755 PE=1 SV=2" "0.007" "False" "2.781" "1" "1" "1" "1" "1200" "130.8" "6.37" "2.81" "1" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity" "" "85449" "ENSG00000149633" "KIAA1755" "Q5JYT7; Q9C0A8" "" "" "0" "0" "0.900" "0.955" "0.900" "0.885" "0.794" "0.838" "0.885" "0.961" "1.801" "124.9" "112.4" "119.2" "112.4" "110.5" "99.1" "104.6" "110.5" "119.9" "224.9" "" "" "" "" "" "" "" "" "" "" "112.3" "90.9" "107.9" "109.7" "91.2" "99.1" "78.3" "97.6" "107.3" "80.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6959452537761872804" "False" "High" "IsMasterProtein" "Q8TB45" "DEP domain-containing mTOR-interacting protein OS=Homo sapiens OX=9606 GN=DEPTOR PE=1 SV=2" "0.007" "False" "2.777" "2" "1" "1" "1" "409" "46.3" "8.07" "3.50" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "enzyme regulator activity;other molecular function" "Pf00610" "64798" "ENSG00000155792" "DEPTOR" "B2RCL9; B4DN97; E7EV87; hsa:64798; Q8TB45; Q96EQ1; Q9H0R7; Q9H894; Q9HA07" "Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; Clear cell renal cell carcinoma pathways; Fragile X syndrome; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Autophagy; p53 transcriptional gene network; Pleural mesothelioma; Network map of SARS-CoV-2 signaling pathway; DYRK1A involvement regarding cell proliferation in brain development; ADHD and autism (ASD) linked metabolic pathways and SNP" "" "10" "0" "1.053" "0.826" "0.939" "1.040" "0.870" "1.032" "0.669" "1.075" "9.011" "45.3" "47.8" "37.4" "42.6" "47.2" "39.4" "46.8" "30.3" "48.7" "408.6" "" "" "" "" "" "" "" "" "" "" "40.8" "38.6" "33.9" "41.6" "38.9" "39.4" "35.0" "26.8" "43.6" "145.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6384672400329607231" "False" "High" "IsMasterProtein" "Q64LD2" "WD repeat-containing protein 25 OS=Homo sapiens OX=9606 GN=WDR25 PE=1 SV=3" "0.007" "False" "2.768" "1" "1" "1" "1" "544" "60.1" "9.00" "2.15" "1" "" "" "" "Pf00400" "79446" "ENSG00000176473" "WDR25" "A8K7E5; hsa:79446; Q64LD2; Q6NVV6; Q86TQ4; Q9BTK5" "" "" "0" "0" "1.045" "1.124" "0.934" "1.139" "1.144" "1.105" "1.134" "1.031" "0.937" "79.5" "83.1" "89.4" "74.3" "90.6" "91.0" "87.9" "90.2" "82.0" "74.6" "" "" "" "" "" "" "" "" "" "" "71.5" "67.3" "80.8" "72.5" "74.7" "91.0" "65.8" "79.7" "73.4" "26.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7375312169873933341" "False" "High" "IsMasterProtein" "Q92564" "DCN1-like protein 4 OS=Homo sapiens OX=9606 GN=DCUN1D4 PE=1 SV=2" "0.007" "False" "2.767" "4" "1" "1" "1" "292" "34.0" "5.88" "2.70" "1" "protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03556" "23142" "ENSG00000109184" "DCUN1D4" "B4DH25; hsa:23142; Q7Z3F3; Q7Z6B8; Q92564" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4007591706154991745" "False" "High" "IsMasterProtein" "Q2PPJ7" "Ral GTPase-activating protein subunit alpha-2 OS=Homo sapiens OX=9606 GN=RALGAPA2 PE=1 SV=2" "0.007" "False" "2.762" "1" "1" "1" "1" "1873" "210.6" "6.07" "2.23" "1" "other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf02145, Pf20412" "57186" "ENSG00000188559" "RALGAPA2" "hsa:57186; Q2PPJ7; Q4VXU6; Q5JUA3; Q5JUA4; Q5T9K3; Q96CX9; Q9BQT7; Q9H9D9; Q9ULE8" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.172" "0.629" "1.311" "1.070" "1.245" "0.805" "1.463" "1.616" "0.926" "16.3" "19.1" "10.2" "21.3" "17.4" "20.2" "13.1" "23.8" "26.3" "15.1" "" "" "" "" "" "" "" "" "" "" "14.6" "15.4" "9.2" "20.8" "14.4" "20.2" "9.8" "21.0" "23.5" "5.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7173592296681882204" "False" "High" "IsMasterProtein" "Q15651" "High mobility group nucleosome-binding domain-containing protein 3 OS=Homo sapiens OX=9606 GN=HMGN3 PE=1 SV=2" "0.007" "False" "2.761" "9" "1" "6" "1" "99" "10.7" "9.66" "16.15" "1" "cell organization and biogenesis" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01101" "9324" "ENSG00000118418" "HMGN3" "B2RD37; hsa:9324; Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7" "" "" "0" "0" "1.096" "1.068" "0.924" "0.963" "1.106" "0.999" "1.053" "0.958" "0.822" "341.5" "374.2" "364.6" "315.4" "328.7" "377.8" "341.1" "359.4" "327.0" "280.8" "" "" "" "" "" "" "" "" "" "" "307.0" "302.8" "329.8" "307.9" "271.3" "377.8" "255.4" "317.5" "292.6" "100.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3289873417268458662" "False" "High" "IsMasterProtein" "Q9NX40" "OCIA domain-containing protein 1 OS=Homo sapiens OX=9606 GN=OCIAD1 PE=1 SV=1" "0.007" "False" "2.755" "4" "1" "2" "1" "245" "27.6" "7.49" "6.99" "1" "transport;other biological processes" "ER/Golgi;other cytoplasmic organelle" "" "Pf07051" "54940" "ENSG00000109180" "OCIAD1" "C9K030; G8JLN7; hsa:54940; Q9BZE8; Q9NX40" "" "" "0" "0" "1.009" "1.077" "0.992" "1.164" "1.050" "1.185" "1.157" "1.069" "0.958" "93.5" "94.4" "100.7" "92.8" "108.8" "98.2" "110.8" "108.2" "99.9" "89.6" "" "" "" "" "" "" "" "" "" "" "84.1" "76.3" "91.1" "90.6" "89.8" "98.2" "83.0" "95.6" "89.4" "32.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4922430964326819838" "False" "High" "IsMasterProtein" "Q13686" "Nucleic acid dioxygenase ALKBH1 OS=Homo sapiens OX=9606 GN=ALKBH1 PE=1 SV=2" "0.007" "False" "2.750" "5" "1" "1" "1" "389" "43.8" "7.08" "2.72" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "mitochondrion;ER/Golgi;nucleus;other cell component" "signal transduction activity or receptor binding;nucleic acid binding activity;other molecular function" "Pf13532" "8846" "ENSG00000100601" "ALKBH1" "Q13686; Q8TAU1; Q9ULA7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3999594216140566415" "False" "High" "IsMasterProtein" "P83369" "U7 snRNA-associated Sm-like protein LSm11 OS=Homo sapiens OX=9606 GN=LSM11 PE=1 SV=2" "0.007" "False" "2.731" "3" "1" "1" "1" "360" "39.5" "10.99" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "nucleic acid binding activity" "" "134353" "ENSG00000155858" "LSM11" "A0AVQ1; hsa:134353; P83369; Q7Z7P0; Q8N975" "" "RNA Polymerase II Transcription Termination; SLBP independent Processing of Histone Pre-mRNAs; SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "748867624032995252" "False" "High" "IsMasterProtein" "Q9H6S3" "Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens OX=9606 GN=EPS8L2 PE=1 SV=2" "0.007" "False" "2.731" "1" "1" "1" "1" "715" "80.6" "6.84" "2.93" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf00018, Pf08416, Pf18016" "64787" "ENSG00000177106" "EPS8L2" "B3KSX1; B7ZKL3; hsa:64787; Q53GM8; Q8WYW7; Q96K06; Q9H6K9; Q9H6S3" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8956939058796420982" "False" "High" "IsMasterProtein" "Q8NGA1" "Olfactory receptor 1M1 OS=Homo sapiens OX=9606 GN=OR1M1 PE=2 SV=1" "0.007" "False" "2.727" "2" "1" "2" "1" "313" "34.8" "8.91" "3.23" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "125963" "ENSG00000170929" "OR1M1" "B9EHA6; hsa:125963; Q6IFJ3; Q8NGA1; Q96R91" "" "Expression and translocation of olfactory receptors" "1" "0" "0.918" "1.117" "0.865" "1.086" "0.765" "1.143" "1.128" "1.098" "1.055" "63.7" "58.5" "71.2" "55.1" "69.2" "48.7" "72.8" "71.9" "70.0" "67.2" "" "" "" "" "" "" "" "" "" "" "57.3" "47.3" "64.4" "53.8" "57.1" "48.7" "54.5" "63.5" "62.6" "24.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4502838028789951010" "False" "High" "IsMasterProtein" "P51397" "Death-associated protein 1 OS=Homo sapiens OX=9606 GN=DAP PE=1 SV=3" "0.007" "False" "2.718" "8" "1" "5" "1" "102" "11.2" "9.32" "10.48" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "" "other molecular function" "Pf15228" "1611" "ENSG00000112977" "DAP" "hsa:1611; P51397; Q6FGC3; Q9BUC9" "" "" "0" "0" "0.942" "0.819" "0.860" "0.883" "0.967" "0.956" "1.018" "0.887" "0.732" "218.0" "205.4" "178.6" "187.4" "192.4" "210.8" "208.5" "222.0" "193.4" "159.6" "" "" "" "" "" "" "" "" "" "" "196.0" "166.2" "161.5" "183.0" "158.8" "210.8" "156.1" "196.1" "173.0" "57.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155528844813379728" "False" "High" "IsMasterProtein" "Q68CZ2" "Tensin-3 OS=Homo sapiens OX=9606 GN=TNS3 PE=1 SV=2" "0.007" "False" "2.710" "1" "1" "1" "1" "1445" "155.2" "6.81" "2.80" "1" "other metabolic processes" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00017, Pf08416, Pf10409" "64759" "ENSG00000136205" "TNS3" "B2RNV1; hsa:64759; Q68CZ2; Q6IPQ2; Q8IZW7; Q8NAD0; Q96PE0; Q96S48" "" "MET interacts with TNS proteins" "1" "0" "1.039" "0.939" "0.908" "0.732" "1.136" "1.275" "1.040" "0.882" "3.531" "26.9" "27.9" "25.2" "24.4" "19.7" "30.5" "34.3" "27.9" "23.7" "94.9" "" "" "" "" "" "" "" "" "" "" "24.2" "22.6" "22.8" "23.8" "16.2" "30.5" "25.7" "24.7" "21.2" "33.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7143180709810206391" "False" "High" "IsMasterProtein" "Q9NS37" "CREB/ATF bZIP transcription factor OS=Homo sapiens OX=9606 GN=CREBZF PE=1 SV=2" "0.007" "False" "2.707" "3" "1" "1" "1" "354" "37.1" "5.24" "2.75" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00170" "58487" "ENSG00000137504" "CREBZF" "B2R8Q9; hsa:58487; Q0P5U9; Q52LT3; Q9NS37" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8431267486707138909" "False" "High" "IsMasterProtein" "Q8TEA7" "TBC domain-containing protein kinase-like protein OS=Homo sapiens OX=9606 GN=TBCK PE=1 SV=4" "0.007" "False" "2.707" "2" "1" "2" "1" "893" "100.6" "6.58" "5.07" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069, Pf00566, Pf00581" "93627" "ENSG00000145348" "TBCK" "B9A6J1; hsa:93627; Q4W5B3; Q4W5E1; Q6NUP4; Q8N7M8; Q8TEA7; Q8WW57; Q96GV6; Q9P080" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5519015022968038253" "False" "High" "IsMasterProtein" "Q86X10" "Ral GTPase-activating protein subunit beta OS=Homo sapiens OX=9606 GN=RALGAPB PE=1 SV=1" "0.007" "False" "2.696" "1" "1" "1" "1" "1494" "166.7" "6.79" "3.54" "1" "other biological processes" "" "enzyme regulator activity;other molecular function" "Pf20412" "57148" "ENSG00000170471" "RALGAPB" "A2A2E8; A2A2E9; hsa:57148; Q5TG31; Q86X10; Q8N3D1; Q8WWC0; Q9H3X8; Q9UJR1; Q9ULK1; Q9Y3G9" "" "Translocation of SLC2A4 (GLUT4) to the plasma membrane" "1" "0" "1.217" "1.029" "1.185" "0.920" "1.126" "1.215" "1.154" "1.032" "1.122" "49.6" "60.4" "51.1" "58.9" "45.7" "55.9" "60.3" "57.3" "51.2" "55.7" "" "" "" "" "" "" "" "" "" "" "44.6" "48.9" "46.2" "57.4" "37.7" "55.9" "45.2" "50.6" "45.8" "19.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7828527280741994957" "False" "High" "IsMasterProtein" "O75971" "snRNA-activating protein complex subunit 5 OS=Homo sapiens OX=9606 GN=SNAPC5 PE=1 SV=1" "0.007" "False" "2.693" "9" "1" "1" "1" "98" "11.3" "4.58" "2.98" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf15497" "10302" "ENSG00000174446" "SNAPC5" "A8K7N6; hsa:10302; O75971; Q96CF3" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA polymerase II transcribes snRNA genes" "3" "0" "0.983" "1.195" "1.044" "0.861" "1.252" "0.989" "1.281" "1.270" "1.111" "55.9" "54.9" "66.8" "58.4" "48.1" "70.0" "55.3" "71.6" "71.0" "62.1" "" "" "" "" "" "" "" "" "" "" "50.3" "44.5" "60.4" "57.0" "39.7" "70.0" "41.4" "63.2" "63.5" "22.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5027095919971470310" "False" "High" "IsMasterProtein" "Q5VVJ2" "Deubiquitinase MYSM1 OS=Homo sapiens OX=9606 GN=MYSM1 PE=1 SV=1" "0.007" "False" "2.685" "1" "1" "1" "1" "828" "95.0" "5.53" "1.76" "1" "cell organization and biogenesis;protein metabolism;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00249, Pf01398, Pf04433" "114803" "ENSG00000162601" "MYSM1" "A8KA54; B3KX65; hsa:114803; Q5VVJ2; Q68DD3; Q6AI53; Q7Z3G8; Q96PX3" "" "Metalloprotease DUBs" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3674016433927487468" "False" "High" "IsMasterProtein" "Cont_P02663" "Alpha-S2-casein OS=Bos taurus OX=9913 GN=CSN1S2 PE=1 SV=2" "0.007" "True" "2.669" "4" "1" "1" "1" "222" "26.0" "8.43" "2.42" "1" "stress response;other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00363" "109560546; 282209" "ENSBIXG00000025508; ENSBIXG00005028072; ENSBTAG00000005005" "CSN1S2; LOC109560546; LOC113894643" "A0A4W2DUG8; A0A6P5BZ34; biu:109560546; bta:282209; P02663; Q1RMQ6; Q9TR51" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1220835464658620030" "False" "High" "IsMasterProtein" "Q7L2E3" "ATP-dependent RNA helicase DHX30 OS=Homo sapiens OX=9606 GN=DHX30 PE=1 SV=1" "0.008" "False" "2.666" "1" "1" "1" "1" "1194" "133.9" "8.78" "2.08" "1" "cell organization and biogenesis;developmental processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271, Pf07717, Pf21010" "22907" "ENSG00000132153" "DHX30" "A8K5F1; hsa:22907; O94965; Q7L2E3; Q7Z753; Q96CH4; Q9NUQ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5675061502284678202" "False" "High" "IsMasterProtein" "Q9ULJ7" "Ankyrin repeat domain-containing protein 50 OS=Homo sapiens OX=9606 GN=ANKRD50 PE=1 SV=4" "0.008" "False" "2.664" "1" "2" "2" "1" "1429" "155.8" "6.60" "4.99" "2" "transport" "other cytoplasmic organelle" "" "Pf12796, Pf13637" "57182" "ENSG00000151458" "ANKRD50" "A8K4V3; B4DHJ6; E9PDW0; hsa:57182; Q6N064; Q6ZSE6; Q9ULJ7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "325955711170823186" "False" "High" "IsMasterProtein" "Q9UIF9" "Bromodomain adjacent to zinc finger domain protein 2A OS=Homo sapiens OX=9606 GN=BAZ2A PE=1 SV=4" "0.008" "False" "2.654" "1" "1" "1" "1" "1905" "211.1" "6.64" "2.65" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00439, Pf00628, Pf01429, Pf02791, Pf15612, Pf15613" "11176" "ENSG00000076108" "BAZ2A" "B3KN66; hsa:11176; O00536; O15030; Q68DI8; Q96H26; Q9UIF9" "" "NoRC negatively regulates rRNA expression" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3092992993917372459" "False" "High" "IsMasterProtein" "Q9HAH7" "Probable fibrosin-1 OS=Homo sapiens OX=9606 GN=FBRS PE=1 SV=3" "0.008" "False" "2.654" "2" "1" "1" "1" "460" "48.4" "9.95" "2.94" "1" "" "" "" "Pf15336" "64319" "ENSG00000156860" "FBRS" "B4DP86; hsa:64319; Q96CI9; Q9H9X4; Q9HAH7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8750052983451588697" "False" "High" "IsMasterProtein" "O43166" "Signal-induced proliferation-associated 1-like protein 1 OS=Homo sapiens OX=9606 GN=SIPA1L1 PE=1 SV=4" "0.008" "False" "2.636" "1" "2" "2" "2" "1804" "199.9" "8.19" "2.17" "2" "cell organization and biogenesis;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity" "Pf00595, Pf02145, Pf11881, Pf21022" "26037" "ENSG00000197555" "SIPA1L1" "hsa:26037; J3KP19; O43166; O95321; Q9UDU4; Q9UNU4" "" "Neurexins and neuroligins" "1" "0" "1.150" "1.184" "1.130" "1.008" "1.082" "1.306" "1.152" "1.099" "1.017" "76.7" "88.2" "90.8" "86.7" "77.3" "83.0" "100.2" "88.4" "84.3" "78.0" "" "" "" "" "" "" "" "" "" "" "69.0" "71.4" "82.1" "84.6" "63.8" "83.0" "75.0" "78.1" "75.5" "27.9" "2" "2" "2" "2" "2" "2" "2" "2" "2" "2" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4681689282303476282" "False" "High" "IsMasterProtein" "Q9BX95" "Sphingosine-1-phosphate phosphatase 1 OS=Homo sapiens OX=9606 GN=SGPP1 PE=1 SV=2" "0.008" "False" "2.632" "2" "1" "1" "1" "441" "49.1" "8.82" "2.71" "1" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf01569" "81537" "ENSG00000126821; ENSG00000285281" "SGPP1" "B2RAH0; hsa:81537; Q9BX95; Q9H189" "Sphingolipid metabolism: integrated pathway; Sphingolipid metabolism in senescence; Biosynthesis and turnover of 1-deoxy-sphingoid bases" "Sphingolipid catabolism" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2422593516059937824" "False" "High" "IsMasterProtein" "Q14055" "Collagen alpha-2(IX) chain OS=Homo sapiens OX=9606 GN=COL9A2 PE=1 SV=2" "0.008" "False" "2.632" "1" "1" "1" "1" "689" "65.1" "9.17" "2.69" "1" "cell organization and biogenesis;developmental processes" "non-structural extracellular;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf01391" "1298" "ENSG00000049089" "COL9A2" "B2RMP9; hsa:1298; Q14055" "PI3K-Akt signaling pathway; Multiple epiphyseal dysplasia and pseudoachondroplasia genes" "Collagen degradation; Signaling by PDGF; Assembly of collagen fibrils and other multimeric structures; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization" "10" "0" "0.908" "0.892" "0.852" "0.765" "0.838" "0.854" "0.898" "0.924" "0.730" "89.8" "81.6" "80.1" "76.5" "68.7" "75.3" "76.7" "80.6" "83.0" "65.6" "" "" "" "" "" "" "" "" "" "" "80.7" "66.0" "72.5" "74.7" "56.7" "75.3" "57.4" "71.2" "74.2" "23.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2596521025155403540" "False" "High" "IsMasterProtein" "Q9BXM9" "FSD1-like protein OS=Homo sapiens OX=9606 GN=FSD1L PE=1 SV=2" "0.008" "False" "2.632" "2" "1" "1" "1" "530" "59.5" "6.20" "2.46" "1" "" "" "" "Pf00622" "83856" "ENSG00000106701" "FSD1L" "A2A338; A6NKH7; B7Z5S6; B7Z5W3; hsa:83856; Q5T879; Q5T880; Q9BXM9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1796554414882976290" "False" "High" "IsMasterProtein" "Q8TCG1" "Protein CIP2A OS=Homo sapiens OX=9606 GN=CIP2A PE=1 SV=2" "0.008" "False" "2.623" "1" "1" "1" "1" "905" "102.1" "6.23" "3.21" "1" "cell organization and biogenesis;stress response" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf21044" "57650" "ENSG00000163507" "CIP2A" "A1L4J7; B9EGC3; hsa:57650; Q6P4G6; Q8TCG1; Q8WVP8; Q96PI2; Q9H9C6; Q9P204" "Netrin-UNC5B signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8380855263151822429" "False" "High" "IsMasterProtein" "Q96EC8" "Protein YIPF6 OS=Homo sapiens OX=9606 GN=YIPF6 PE=1 SV=2" "0.008" "False" "2.614" "5" "1" "1" "1" "236" "26.2" "5.64" "2.03" "1" "transport;developmental processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf04893" "286451" "ENSG00000181704" "YIPF6" "B4E1U7; G5E997; hsa:286451; Q5JP08; Q96EC8" "" "Golgi Associated Vesicle Biogenesis" "1" "0" "1.271" "1.414" "1.022" "1.154" "1.046" "1.073" "1.234" "1.218" "0.807" "24.3" "30.9" "34.4" "24.9" "28.1" "25.5" "26.1" "30.0" "29.6" "19.6" "" "" "" "" "" "" "" "" "" "" "21.9" "25.0" "31.1" "24.3" "23.2" "25.5" "19.6" "26.5" "26.5" "7.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "790409286945352523" "False" "High" "IsMasterProtein" "O14893" "Gem-associated protein 2 OS=Homo sapiens OX=9606 GN=GEMIN2 PE=1 SV=1" "0.008" "False" "2.613" "3" "1" "1" "1" "280" "31.6" "5.58" "3.00" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "" "Pf04938" "8487" "ENSG00000092208" "GEMIN2" "B2R9W8; hsa:8487; O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79" "" "snRNP Assembly; SARS-CoV-2 modulates host translation machinery" "2" "0" "1.272" "0.875" "1.068" "1.187" "1.092" "1.149" "1.196" "0.909" "1.530" "99.4" "126.5" "87.0" "106.1" "118.0" "108.5" "114.2" "118.8" "90.3" "152.0" "" "" "" "" "" "" "" "" "" "" "89.4" "102.3" "78.7" "103.6" "97.3" "108.5" "85.5" "105.0" "80.8" "54.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4670744058278942272" "False" "High" "IsMasterProtein" "Q9UN74" "Protocadherin alpha-4 OS=Homo sapiens OX=9606 GN=PCDHA4 PE=1 SV=1" "0.008" "False" "2.600" "2" "2" "2" "2" "947" "102.2" "5.08" "2.13" "2" "cell adhesion;developmental processes" "plasma membrane;other membranes" "other molecular function" "Pf00028, Pf08266, Pf15974" "56144" "ENSG00000204967; ENSG00000291652" "PCDHA4" "hsa:56144; O75285; Q2M253; Q9UN74" "GDNF signaling" "" "1" "0" "0.880" "0.798" "0.906" "0.899" "0.892" "0.987" "0.930" "0.902" "0.498" "68.6" "60.4" "54.8" "62.2" "61.7" "61.3" "67.8" "63.8" "61.9" "34.2" "" "" "" "" "" "" "" "" "" "" "61.7" "48.9" "49.6" "60.7" "50.9" "61.3" "50.7" "56.4" "55.4" "12.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1273704181858751884" "False" "High" "IsMasterProtein" "Q8N0X4" "Citramalyl-CoA lyase, mitochondrial OS=Homo sapiens OX=9606 GN=CLYBL PE=1 SV=2" "0.008" "False" "2.589" "2" "1" "1" "1" "340" "37.3" "8.73" "3.59" "1" "cell organization and biogenesis;other biological processes" "mitochondrion" "other molecular function" "Pf03328" "171425" "ENSG00000125246" "CLYBL" "hsa:171425; Q5W0F7; Q8N0X4; Q8TDH8" "" "" "0" "0" "0.946" "0.958" "0.872" "0.939" "0.930" "0.849" "0.920" "0.958" "0.678" "218.5" "206.6" "209.3" "190.5" "205.1" "203.1" "185.4" "200.9" "209.4" "148.1" "" "" "" "" "" "" "" "" "" "" "196.4" "167.2" "189.4" "186.0" "169.3" "203.1" "138.9" "177.4" "187.4" "52.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5377093586219491132" "False" "High" "IsMasterProtein" "Q5VW36" "Focadhesin OS=Homo sapiens OX=9606 GN=FOCAD PE=1 SV=2" "0.008" "False" "2.584" "0" "1" "1" "1" "1801" "199.9" "6.62" "2.57" "1" "other biological processes" "cytosol;other cell component" "" "Pf11229, Pf12530" "54914" "ENSG00000188352" "FOCAD" "D3DRJ9; hsa:54914; Q5VW36; Q6ZME1; Q8IZG0; Q96JM8; Q96MS9; Q9BVF3; Q9NX87" "" "" "0" "0" "1.055" "0.889" "0.783" "0.925" "0.819" "0.903" "0.871" "0.900" "1.007" "51.8" "54.7" "46.1" "40.5" "47.9" "42.4" "46.8" "45.1" "46.6" "52.1" "" "" "" "" "" "" "" "" "" "" "46.6" "44.2" "41.7" "39.6" "39.6" "42.4" "35.0" "39.8" "41.7" "18.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6713698624635577932" "False" "High" "IsMasterProtein" "Q9NWQ9" "Uncharacterized protein C14orf119 OS=Homo sapiens OX=9606 GN=C14orf119 PE=1 SV=1" "0.008" "False" "2.573" "6" "1" "1" "1" "140" "16.0" "4.94" "2.78" "1" "" "cytosol;mitochondrion" "" "Pf14969" "55017" "ENSG00000179933" "C14orf119" "hsa:55017; Q6IAA7; Q9NWQ9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1278451535878426302" "False" "High" "IsMasterProtein" "Q07820" "Induced myeloid leukemia cell differentiation protein Mcl-1 OS=Homo sapiens OX=9606 GN=MCL1 PE=1 SV=3" "0.008" "False" "2.569" "6" "1" "1" "1" "350" "37.3" "5.66" "2.09" "1" "cell organization and biogenesis;stress response;transport;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;nucleus;other cell component" "transporter activity;other molecular function" "Pf00452" "4170" "ENSG00000143384" "MCL1" "B2R6B2; D3DV03; D3DV04; hsa:4170; Q07820; Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1" "Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced HIF-1 survival signaling; Hematopoietic stem cell gene regulation by GABP alpha/beta complex; PI3K-Akt signaling pathway; MicroRNA network associated with chronic lymphocytic leukemia; Host-pathogen interaction of human coronaviruses - apoptosis; Pleural mesothelioma" "Signaling by ALK fusions and activated point mutants; Interleukin-4 and Interleukin-13 signaling" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5765405585808973538" "False" "High" "IsMasterProtein" "P32780" "General transcription factor IIH subunit 1 OS=Homo sapiens OX=9606 GN=GTF2H1 PE=1 SV=1" "0.008" "False" "2.564" "2" "1" "1" "1" "548" "62.0" "8.66" "0.00" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf03909, Pf08567" "2965" "ENSG00000110768; ENSG00000288114" "GTF2H1" "B3KXE0; D3DQY2; hsa:2965; P32780; Q6I9Y7; Q9H5K5; Q9NQD9" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "NoRC negatively regulates rRNA expression; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "186297121193818465" "False" "High" "IsMasterProtein" "Q5QJ74" "Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens OX=9606 GN=TBCEL PE=1 SV=2" "0.008" "False" "2.557" "2" "1" "1" "1" "424" "48.2" "5.38" "2.41" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf14560, Pf14580" "219899" "ENSG00000154114" "TBCEL" "hsa:219899; Q0VAN6; Q5QJ74" "" "" "0" "0" "1.251" "1.087" "0.924" "1.154" "1.044" "1.050" "1.066" "1.028" "1.489" "69.7" "87.2" "75.8" "64.4" "80.4" "72.8" "73.2" "74.3" "71.7" "103.8" "" "" "" "" "" "" "" "" "" "" "62.7" "70.6" "68.5" "62.9" "66.4" "72.8" "54.8" "65.6" "64.1" "37.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8705031560039491715" "False" "High" "IsMasterProtein" "Q8IUQ4" "E3 ubiquitin-protein ligase SIAH1 OS=Homo sapiens OX=9606 GN=SIAH1 PE=1 SV=2" "0.008" "False" "2.555" "3" "1" "1" "1" "282" "31.1" "6.80" "0.00" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03145, Pf21361, Pf21362" "6477" "ENSG00000196470" "SIAH1" "A0FKF3; hsa:6477; O43269; Q49A58; Q8IUQ4; Q92880" "Parkin-ubiquitin proteasomal system pathway; miRNA regulation of p53 pathway in prostate cancer; HIPK2 in kidney fibrosis; 16p11.2 proximal deletion syndrome" "Antigen processing: Ubiquitination & Proteasome degradation; Amyloid fiber formation; Netrin-1 signaling" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1373534053104032037" "False" "High" "IsMasterProtein" "O14653" "Golgi SNAP receptor complex member 2 OS=Homo sapiens OX=9606 GN=GOSR2 PE=1 SV=2" "0.009" "False" "2.554" "5" "1" "2" "1" "212" "24.8" "8.06" "0.00" "1" "cell organization and biogenesis;transport" "other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "other molecular function" "Pf12352" "9570" "ENSG00000108433" "GOSR2" "D3DXJ5; D3DXJ6; hsa:9570; O14653; Q8N4B8; Q96DA5; Q9BZZ4" "" "COPI-mediated anterograde transport; Intra-Golgi traffic; COPII-mediated vesicle transport; XBP1(S) activates chaperone genes; Cargo concentration in the ER" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6450928307981678161" "False" "High" "IsMasterProtein" "A4D2B0" "Metallo-beta-lactamase domain-containing protein 1 OS=Homo sapiens OX=9606 GN=MBLAC1 PE=1 SV=1" "0.009" "False" "2.552" "5" "1" "1" "1" "266" "27.2" "4.86" "3.31" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00753" "255374" "ENSG00000214309" "MBLAC1" "A4D2B0; hsa:255374; Q8N5X8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4301094259953391883" "False" "High" "IsMasterProtein" "Q86VZ1" "P2Y purinoceptor 8 OS=Homo sapiens OX=9606 GN=P2RY8 PE=1 SV=1" "0.009" "False" "2.549" "6" "1" "1" "1" "359" "40.6" "9.50" "0.00" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00001" "286530" "ENSG00000182162; ENSG00000292333" "P2RY8" "hsa:286530; Q86VZ1" "Purinergic signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-7932512641698154547" "False" "High" "IsMasterProtein" "Q9UH92" "Max-like protein X OS=Homo sapiens OX=9606 GN=MLX PE=1 SV=2" "0.009" "False" "2.532" "3" "1" "1" "1" "298" "33.3" "8.06" "0.00" "1" "other biological processes" "other membranes;cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "6945" "ENSG00000108788" "MLX" "A8K2J3; B2RAV8; B2RD73; hsa:6945; Q53XM6; Q96FL2; Q9H2V0; Q9H2V1; Q9H2V2; Q9NXN3; Q9UH92" "Nonalcoholic fatty liver disease" "ChREBP activates metabolic gene expression" "2" "0" "0.853" "1.046" "0.889" "0.908" "1.147" "0.835" "0.887" "0.971" "1.062" "115.5" "98.5" "120.8" "102.6" "104.8" "132.5" "96.4" "102.4" "112.1" "122.6" "" "" "" "" "" "" "" "" "" "" "103.8" "79.7" "109.3" "100.2" "86.5" "132.5" "72.2" "90.5" "100.3" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6257492621702889989" "False" "High" "IsMasterProtein" "Q10589" "Bone marrow stromal antigen 2 OS=Homo sapiens OX=9606 GN=BST2 PE=1 SV=1" "0.009" "False" "2.529" "4" "1" "1" "1" "180" "19.8" "5.60" "2.64" "1" "stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf16716" "684" "ENSG00000130303" "BST2" "A8K4Y4; hsa:684; Q10589; Q53G07" "Ebola virus infection in host; Host-pathogen interaction of human coronaviruses - MAPK signaling" "Neutrophil degranulation; Interferon alpha/beta signaling; SARS-CoV-1 activates/modulates innate immune responses" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3509057874585176951" "False" "High" "IsMasterProtein" "Q9GZS1" "DNA-directed RNA polymerase I subunit RPA49 OS=Homo sapiens OX=9606 GN=POLR1E PE=1 SV=3" "0.009" "False" "2.528" "3" "1" "1" "1" "419" "47.2" "8.94" "1.69" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf06870" "64425" "ENSG00000137054" "POLR1E" "hsa:64425; Q5VZT3; Q8NBA9; Q96L20; Q9GZS1" "Pyrimidine metabolism; Eukaryotic transcription initiation; 2q13 copy number variation syndrome; Rubinstein-Taybi syndrome 1" "B-WICH complex positively regulates rRNA expression; NoRC negatively regulates rRNA expression; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Initiation; RNA Polymerase I Transcription Termination" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6904247061824975509" "False" "High" "IsMasterProtein" "Q9NP73" "UDP-N-acetylglucosamine transferase subunit ALG13 OS=Homo sapiens OX=9606 GN=ALG13 PE=1 SV=2" "0.009" "False" "2.517" "1" "1" "1" "1" "1137" "126.0" "6.74" "2.54" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf02338, Pf04101" "79868" "ENSG00000101901" "ALG13" "B1AKD6; B1AKM1; B2R5L5; B7Z6J0; B7Z804; B7Z847; B7Z9A8; B7ZAJ1; B7ZB57; hsa:79868; Q17RC3; Q5JXY9; Q9H5U8; Q9NP73" "N-glycan biosynthesis" "Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein; Defective ALG14 causes ALG14-CMS" "3" "0" "1.187" "1.136" "1.009" "1.038" "0.937" "1.091" "0.984" "0.964" "0.786" "330.3" "392.3" "375.2" "333.2" "343.0" "309.4" "360.4" "325.2" "318.3" "259.7" "" "" "" "" "" "" "" "" "" "" "297.0" "317.4" "339.4" "325.3" "283.0" "309.4" "269.8" "287.2" "284.9" "92.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4312046131050647574" "False" "High" "IsMasterProtein" "Q9NPR2" "Semaphorin-4B OS=Homo sapiens OX=9606 GN=SEMA4B PE=1 SV=4" "0.009" "False" "2.516" "1" "1" "1" "1" "837" "92.7" "7.05" "2.26" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding" "Pf01403, Pf01437" "10509" "ENSG00000185033" "SEMA4B" "hsa:10509; J3KNP4; Q6UXE3; Q8WVP9; Q96FK5; Q9C0B8; Q9H691; Q9NPM8; Q9NPN0; Q9NPR2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1299215584084045003" "False" "High" "IsMasterProtein" "Q9BRQ3" "Uridine diphosphate glucose pyrophosphatase NUDT22 OS=Homo sapiens OX=9606 GN=NUDT22 PE=1 SV=3" "0.009" "False" "2.512" "6" "1" "1" "1" "303" "32.6" "5.11" "4.63" "1" "" "nucleus" "other molecular function" "" "84304" "ENSG00000149761" "NUDT22" "C9JY06; hsa:84304; Q71RD5; Q9BRQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-681264021479327249" "False" "High" "IsMasterProtein" "O95396" "Adenylyltransferase and sulfurtransferase MOCS3 OS=Homo sapiens OX=9606 GN=MOCS3 PE=1 SV=1" "0.009" "False" "2.509" "3" "1" "1" "1" "460" "49.6" "6.21" "2.47" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf00581, Pf00899" "27304" "ENSG00000124217" "MOCS3" "hsa:27304; O95396" "Metabolic Epileptic Disorders" "Molybdenum cofactor biosynthesis" "2" "0" "1.101" "0.860" "1.015" "1.121" "1.035" "1.288" "0.858" "0.755" "0.991" "23.3" "25.7" "20.1" "23.7" "26.2" "24.2" "30.1" "20.0" "17.6" "23.1" "" "" "" "" "" "" "" "" "" "" "21.0" "20.8" "18.2" "23.1" "21.6" "24.2" "22.5" "17.7" "15.8" "8.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8587820896620704041" "False" "High" "IsMasterProtein" "O15417" "Trinucleotide repeat-containing gene 18 protein OS=Homo sapiens OX=9606 GN=TNRC18 PE=1 SV=3" "0.009" "False" "2.509" "1" "2" "2" "2" "2968" "314.3" "8.70" "2.88" "2" "" "other membranes;cytosol;mitochondrion;nucleus" "other molecular function" "Pf01426, Pf21744" "84629" "ENSG00000182095" "TNRC18" "A8MX41; hsa:84629; O15417; Q96JH1; Q96K91" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413816697731650822" "False" "High" "IsMasterProtein" "Q9BU64" "Centromere protein O OS=Homo sapiens OX=9606 GN=CENPO PE=1 SV=1" "0.009" "False" "2.494" "3" "1" "1" "1" "300" "33.8" "7.71" "3.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf09496" "79172" "ENSG00000138092" "CENPO" "B2RDC0; D6W536; hsa:79172; Q53T55; Q96JV3; Q9BU64" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1875589299266399931" "False" "High" "IsMasterProtein" "Q14139" "Ubiquitin conjugation factor E4 A OS=Homo sapiens OX=9606 GN=UBE4A PE=1 SV=2" "0.009" "False" "2.493" "2" "1" "1" "1" "1066" "122.5" "5.24" "2.19" "1" "protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf04564, Pf10408" "9354" "ENSG00000110344" "UBE4A" "B0YJB6; Q14139; Q2M1H0; Q6P5T4; Q7Z639" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-956583544951272797" "False" "High" "IsMasterProtein" "Q8IY81" "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 OS=Homo sapiens OX=9606 GN=FTSJ3 PE=1 SV=2" "0.009" "False" "2.489" "1" "1" "1" "1" "847" "96.5" "8.40" "1.96" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf01728, Pf07780, Pf11861" "117246" "ENSG00000108592" "FTSJ3" "B2RCA5; D3DU22; hsa:117246; Q8IY81; Q8N3A3; Q8WXX1; Q9BWM4; Q9NXT6" "" "Major pathway of rRNA processing in the nucleolus and cytosol" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4330656270512848682" "False" "High" "IsMasterProtein" "Q8WVR3" "Trafficking protein particle complex subunit 14 OS=Homo sapiens OX=9606 GN=TRAPPC14 PE=1 SV=2" "0.009" "False" "2.484" "2" "1" "1" "1" "580" "62.6" "8.87" "3.59" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity" "Pf15806" "55262" "ENSG00000146826" "TRAPPC14" "A4D2A9; D6W5U4; hsa:55262; Q8WVR3; Q9BQJ1; Q9BUB6; Q9NV47" "" "" "0" "0" "0.863" "0.929" "0.916" "0.996" "0.910" "0.880" "0.876" "0.913" "0.961" "171.4" "147.9" "159.2" "157.0" "170.6" "156.0" "150.8" "150.2" "156.5" "164.7" "" "" "" "" "" "" "" "" "" "" "154.1" "119.6" "144.0" "153.3" "140.8" "156.0" "112.9" "132.7" "140.0" "58.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4240748873796981312" "False" "High" "IsMasterProtein" "O43586" "Proline-serine-threonine phosphatase-interacting protein 1 OS=Homo sapiens OX=9606 GN=PSTPIP1 PE=1 SV=1" "0.009" "False" "2.464" "2" "1" "1" "1" "416" "47.6" "5.45" "2.46" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00018, Pf00611" "9051" "ENSG00000140368" "PSTPIP1" "B5BU74; B5BUK4; hsa:9051; O43585; O43586; O95657" "T-cell receptor signaling pathway" "The NLRP3 inflammasome; Purinergic signaling in leishmaniasis infection" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6962045687038046175" "False" "High" "IsMasterProtein" "Q8NEC7" "Glutathione S-transferase C-terminal domain-containing protein OS=Homo sapiens OX=9606 GN=GSTCD PE=1 SV=2" "0.009" "False" "2.457" "2" "1" "1" "1" "633" "71.0" "7.78" "0.00" "1" "" "other cell component" "other molecular function" "Pf13679" "79807" "ENSG00000138780" "GSTCD" "A8K8J0; A8MVD3; H9KV97; hsa:79807; Q8NEC7; Q9H8S3" "Metapathway biotransformation Phase I and II" "" "1" "0" "1.235" "1.034" "0.723" "1.364" "1.275" "1.369" "1.082" "0.937" "1.071" "88.2" "109.0" "91.2" "63.8" "120.4" "112.5" "120.8" "95.5" "82.7" "94.5" "" "" "" "" "" "" "" "" "" "" "79.3" "88.2" "82.5" "62.3" "99.3" "112.5" "90.5" "84.3" "74.0" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4794650797081618468" "False" "High" "IsMasterProtein" "Q86YS3" "Rab11 family-interacting protein 4 OS=Homo sapiens OX=9606 GN=RAB11FIP4 PE=1 SV=1" "0.009" "False" "2.446" "1" "1" "1" "1" "637" "71.9" "4.87" "3.30" "1" "transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf09457" "84440" "ENSG00000131242" "RAB11FIP4" "hsa:84440; Q52LI1; Q86YS3; Q8N829; Q8NDT7; Q969D8" "NF1 copy number variation syndrome" "" "1" "0" "0.955" "0.994" "1.024" "1.042" "0.997" "1.114" "0.996" "0.892" "0.987" "41.0" "39.2" "40.8" "42.0" "42.7" "40.9" "45.7" "40.9" "36.6" "40.5" "" "" "" "" "" "" "" "" "" "" "36.9" "31.7" "36.9" "41.0" "35.3" "40.9" "34.2" "36.1" "32.7" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6747438511189110572" "False" "High" "IsMasterProtein" "A6NI79" "Coiled-coil domain-containing protein 69 OS=Homo sapiens OX=9606 GN=CCDC69 PE=1 SV=1" "0.009" "False" "2.439" "4" "1" "1" "1" "296" "34.8" "5.76" "2.60" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "" "26112" "ENSG00000198624" "CCDC69" "A6NI79; A8K9X6; hsa:26112" "" "" "0" "0" "0.729" "0.598" "1.285" "1.080" "0.970" "1.022" "0.874" "0.836" "2.969" "17.0" "12.4" "10.2" "21.8" "18.3" "16.5" "17.3" "14.8" "14.2" "50.4" "" "" "" "" "" "" "" "" "" "" "15.3" "10.0" "9.2" "21.3" "15.1" "16.5" "13.0" "13.1" "12.7" "18.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8194889804076803831" "False" "High" "IsMasterProtein" "Q9UBU9" "Nuclear RNA export factor 1 OS=Homo sapiens OX=9606 GN=NXF1 PE=1 SV=1" "0.009" "False" "2.420" "1" "1" "1" "1" "619" "70.1" "8.51" "3.48" "1" "other metabolic processes;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf02136, Pf03943, Pf09162" "10482" "ENSG00000162231" "NXF1" "B4E269; hsa:10482; Q99799; Q9UBU9; Q9UQL2" "mRNA processing" "Transport of the SLBP independent Mature mRNA; Transport of the SLBP Dependant Mature mRNA; Transport of Mature mRNA Derived from an Intronless Transcript; Transport of Mature mRNA derived from an Intron-Containing Transcript" "5" "0" "1.078" "0.986" "1.151" "1.082" "1.214" "1.161" "1.030" "1.037" "1.425" "200.0" "215.7" "197.2" "230.2" "216.5" "242.9" "232.3" "206.1" "207.5" "285.0" "" "" "" "" "" "" "" "" "" "" "179.8" "174.6" "178.4" "224.7" "178.6" "242.9" "174.0" "182.0" "185.6" "101.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8609206004865475892" "False" "High" "IsMasterProtein" "Q96BD8" "Spindle and kinetochore-associated protein 1 OS=Homo sapiens OX=9606 GN=SKA1 PE=1 SV=1" "0.010" "False" "2.411" "3" "1" "1" "1" "255" "29.5" "7.12" "2.38" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "cytoskeletal activity" "Pf07160" "220134" "ENSG00000154839; ENSG00000262634" "SKA1" "B2R9Y6; B4E0P4; hsa:220134; Q96BD8" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4336688759083416299" "False" "High" "IsMasterProtein" "Q15813" "Tubulin-specific chaperone E OS=Homo sapiens OX=9606 GN=TBCE PE=1 SV=1" "0.010" "False" "2.411" "2" "1" "1" "1" "527" "59.3" "6.76" "2.33" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf01302, Pf14560" "6905" "ENSG00000284770" "TBCE" "A8K8C2; B7Z3P1; Q15813" "" "Post-chaperonin tubulin folding pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4252993756600490288" "False" "High" "IsMasterProtein" "Q9BQ24" "Zinc finger FYVE domain-containing protein 21 OS=Homo sapiens OX=9606 GN=ZFYVE21 PE=1 SV=1" "0.010" "False" "2.405" "3" "1" "1" "1" "234" "26.5" "8.41" "3.00" "1" "" "other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363, Pf16696" "79038" "ENSG00000100711" "ZFYVE21" "A8K3A4; hsa:79038; Q86T05; Q96LT1; Q9BQ24" "" "" "0" "0" "1.004" "0.864" "0.920" "0.950" "0.962" "1.047" "0.910" "0.994" "1.540" "164.6" "165.2" "142.2" "151.5" "156.4" "158.4" "172.3" "149.8" "163.5" "253.5" "" "" "" "" "" "" "" "" "" "" "148.0" "133.7" "128.6" "147.9" "129.0" "158.4" "129.0" "132.3" "146.3" "90.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7955470768100520054" "False" "High" "IsMasterProtein" "Q8N6Q8" "Probable methyltransferase-like protein 25 OS=Homo sapiens OX=9606 GN=METTL25 PE=1 SV=2" "0.010" "False" "2.388" "1" "1" "1" "1" "603" "68.2" "7.08" "1.81" "1" "other metabolic processes" "" "other molecular function" "Pf13679" "84190" "ENSG00000127720" "METTL25" "hsa:84190; Q8N6Q8; Q9H5Y3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9180728147775815740" "False" "High" "IsMasterProtein" "Q96A46" "Mitoferrin-2 OS=Homo sapiens OX=9606 GN=SLC25A28 PE=1 SV=1" "0.010" "False" "2.382" "4" "1" "1" "1" "364" "39.2" "8.59" "2.25" "1" "transport" "other membranes;mitochondrion" "transporter activity" "Pf00153" "81894" "ENSG00000155287" "SLC25A28" "hsa:81894; Q4VBZ0; Q5T777; Q86VX5; Q969G8; Q96A46; Q9H2J3" "" "Mitochondrial iron-sulfur cluster biogenesis" "1" "0" "1.168" "1.060" "0.813" "0.781" "1.198" "0.724" "1.025" "1.111" "0.849" "15.8" "18.4" "16.7" "12.8" "12.3" "18.9" "11.4" "16.2" "17.5" "13.4" "" "" "" "" "" "" "" "" "" "" "14.2" "14.9" "15.1" "12.5" "10.2" "18.9" "8.6" "14.3" "15.7" "4.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3163566102457861060" "False" "High" "IsMasterProtein" "Q8IWI9" "MAX gene-associated protein OS=Homo sapiens OX=9606 GN=MGA PE=1 SV=4" "0.010" "False" "2.373" "0" "2" "2" "1" "3065" "336.0" "6.90" "4.61" "2" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf00907, Pf16059" "23269" "ENSG00000174197" "MGA" "B9EGR5; E7ENI0; F5H7K2; hsa:23269; Q8IWI9; Q9H8R3; Q9H9N7; Q9UG69; Q9Y4E9" "Pathways affected in adenoid cystic carcinoma" "Transcriptional Regulation by E2F6" "2" "0" "1.071" "1.093" "0.916" "1.016" "0.974" "1.076" "1.119" "1.016" "0.936" "213.9" "229.2" "233.8" "195.9" "217.4" "208.4" "230.2" "239.4" "217.4" "200.2" "" "" "" "" "" "" "" "" "" "" "192.3" "185.4" "211.4" "191.2" "179.4" "208.4" "172.4" "211.4" "194.5" "71.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "996701164361086035" "False" "High" "IsMasterProtein" "Q96E29" "Transcription termination factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=MTERF3 PE=1 SV=2" "0.010" "False" "2.373" "4" "1" "1" "1" "417" "47.9" "8.53" "3.14" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "nucleic acid binding activity" "Pf02536" "51001" "ENSG00000156469" "MTERF3" "B3KMG6; G3V130; hsa:51001; Q96E29; Q9Y301" "Mitochondrial gene expression" "PINK1-PRKN Mediated Mitophagy" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4922612836964233502" "False" "High" "IsMasterProtein" "Q6P444" "Mitochondrial fission regulator 2 OS=Homo sapiens OX=9606 GN=MTFR2 PE=1 SV=2" "0.010" "False" "2.371" "3" "1" "1" "1" "385" "43.4" "7.01" "0.00" "1" "cell organization and biogenesis;other metabolic processes" "mitochondrion" "" "Pf05308" "113115" "ENSG00000146410" "MTFR2" "A8K8D8; E1P585; hsa:113115; Q5JWR7; Q6P444; Q6ZUE8; Q7L3U6; Q9BZ39" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "2436526655011241506" "False" "High" "IsMasterProtein" "P19793" "Retinoic acid receptor RXR-alpha OS=Homo sapiens OX=9606 GN=RXRA PE=1 SV=1" "0.010" "False" "2.365" "2" "1" "2" "1" "462" "50.8" "7.80" "2.82" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00104, Pf00105, Pf11825" "6256" "ENSG00000186350" "RXRA" "B3KY83; hsa:6256; P19793; Q2NL52; Q2V504" "Vitamin D metabolism; Energy metabolism; Nuclear receptors; Adipogenesis; Liver X receptor pathway; Constitutive androstane receptor pathway; Pregnane X receptor pathway; Vitamin D receptor pathway; PPAR-alpha pathway; Farnesoid X receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcription factor regulation in adipogenesis; Angiopoietin-like protein 8 regulatory pathway; PPAR signaling pathway; Prion disease pathway; PI3K/AKT/mTOR - vitamin D3 signaling; Non-small cell lung cancer; Non-genomic actions of 1,25 dihydroxyvitamin D3; Vitamins A and D - action mechanisms; Nonalcoholic fatty liver disease; Vitamin D in inflammatory diseases; Small cell lung cancer; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Th17 cell differentiation pathway; Kleefstra syndrome; Vitamin A1 and A5/X pathways; Vitamin A and carotenoid metabolism" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; Endogenous sterols; Heme signaling; BMAL1:CLOCK,NPAS2 activates circadian gene expression; Regulation of pyruvate dehydrogenase (PDH) complex; Signaling by Retinoic Acid; Transcriptional activation of mitochondrial biogenesis; Nuclear Receptor transcription pathway; SUMOylation of intracellular receptors; Cytoprotection by HMOX1; Carnitine metabolism; Activation of gene expression by SREBF (SREBP); NR1H2 & NR1H3 regulate gene expression linked to lipogenesis; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose; Transcriptional regulation of granulopoiesis; RORA activates gene expression; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis; Synthesis of bile acids and bile salts via 27-hydroxycholesterol; NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake ; NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis" "59" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8980978827116582562" "False" "High" "IsMasterProtein" "Q07889" "Son of sevenless homolog 1 OS=Homo sapiens OX=9606 GN=SOS1 PE=1 SV=1" "0.010" "False" "2.361" "1" "1" "1" "1" "1333" "152.4" "6.84" "2.53" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00169, Pf00617, Pf00618, Pf00621" "6654" "ENSG00000115904" "SOS1" "A8K2G3; B4DXG2; hsa:6654; Q07889" "IL-5 signaling pathway; Integrin-mediated cell adhesion; Leptin signaling pathway; Prolactin signaling pathway; Pilocytic astrocytoma; Androgen receptor network in prostate cancer; B cell receptor signaling pathway; TNF-alpha signaling pathway; Oncostatin M signaling pathway; Alpha 6 beta 4 signaling pathway; IL-3 signaling pathway; Kit receptor signaling pathway; Focal adhesion; Hepatocyte growth factor receptor signaling; RAC1/PAK1/p38/MMP2 pathway; IL6 signaling pathway; Hepatitis C and hepatocellular carcinoma; TGF-beta signaling pathway; BDNF-TrkB signaling; Physico-chemical features and toxicity-associated pathways; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Chemokine signaling pathway; Embryonic stem cell pluripotency pathways; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PDGFR-beta pathway; miRNA regulation of prostate cancer signaling pathways; Endometrial cancer; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; MAPK cascade; Ras signaling; Epithelial to mesenchymal transition in colorectal cancer; Non-small cell lung cancer; Breast cancer pathway; Acute viral myocarditis; Thermogenesis; EGF/EGFR signaling pathway; Envelope proteins and their potential roles in EDMD physiopathology; Fragile X syndrome; Gastrin signaling pathway; Hepatitis B infection; Melanoma; Thyroid hormones production and peripheral downstream signaling effects; EGFR tyrosine kinase inhibitor resistance; Insulin signaling; IL-2 signaling pathway; MAPK pathway in congenital thyroid cancer; Pleural mesothelioma; Regulation of actin cytoskeleton; Acute myeloid leukemia; 4p16.3 copy number variation; 5q35 copy number variation; EPO receptor signaling; ErbB signaling pathway; T-cell receptor signaling pathway; DNA damage response (only ATM dependent)" "RAC1 GTPase cycle; Role of LAT2/NTAL/LAB on calcium mobilization; FCERI mediated MAPK activation; FCERI mediated Ca+2 mobilization; Potential therapeutics for SARS; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; NRAGE signals death through JNK; G alpha (12/13) signalling events; RET signaling; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Downstream signal transduction; Tie2 Signaling; DAP12 signaling; Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants; Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants; Signaling by PDGFRA extracellular domain mutants; Regulation of KIT signaling; SHC1 events in ERBB2 signaling; SHC1 events in ERBB4 signaling; GRB2 events in ERBB2 signaling; Signaling by ERBB2 KD Mutants; Signaling by ERBB2 TMD/JMD mutants; GRB2 events in EGFR signaling; SHC1 events in EGFR signaling; NCAM signaling for neurite out-growth; Signaling by FGFR1 in disease; Signaling by CSF1 (M-CSF) in myeloid cells; SHC-mediated cascade:FGFR1; FRS-mediated FGFR1 signaling; SHC-mediated cascade:FGFR2; FRS-mediated FGFR2 signaling; Signaling by FGFR2 in disease; SHC-mediated cascade:FGFR3; FRS-mediated FGFR3 signaling; FRS-mediated FGFR4 signaling; SHC-mediated cascade:FGFR4; Signaling by FGFR3 in disease; Activated NTRK2 signals through FRS2 and FRS3; Activation of RAC1; Erythropoietin activates RAS; Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants; EGFR Transactivation by Gastrin; Constitutive Signaling by EGFRvIII; Signaling by ERBB2 ECD mutants; SOS-mediated signalling; Signalling to RAS; SHC-related events triggered by IGF1R; Signaling by FGFR4 in disease; MET activates RAS signaling; Activated NTRK2 signals through RAS; Activated NTRK3 signals through RAS; Constitutive Signaling by Overexpressed ERBB2; Signaling by FLT3 fusion proteins; Signaling by FLT3 ITD and TKD mutants; Signal attenuation; GRB2:SOS provides linkage to MAPK signaling for Integrins ; Interleukin-15 signaling" "120" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1171297253546326275" "False" "High" "IsMasterProtein" "Q6AI08" "HEAT repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=HEATR6 PE=1 SV=1" "0.010" "False" "2.355" "1" "1" "1" "1" "1181" "128.7" "7.03" "2.03" "1" "" "" "" "Pf13251" "63897" "ENSG00000068097" "HEATR6" "B3KXP3; hsa:63897; Q6AI08; Q6MZX1; Q6MZY2; Q8TDM9; Q9H6B3; Q9H6M7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "High" "High" "High" "High" "Not Found" "High" "High" "Not Found" "Not Found" "1" "" "4447255440292633936" "False" "High" "IsMasterProtein" "Q92625" "Ankyrin repeat and SAM domain-containing protein 1A OS=Homo sapiens OX=9606 GN=ANKS1A PE=1 SV=4" "0.010" "False" "2.355" "1" "1" "1" "1" "1134" "123.0" "6.38" "3.51" "1" "developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf00023, Pf00536, Pf00640" "23294" "ENSG00000064999" "ANKS1A" "A2RUC1; B4DQW8; hsa:23294; Q5JYI9; Q5SYR2; Q86WQ7; Q92625" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4463685035548187734" "False" "High" "IsMasterProtein" "Q9GZX6" "Interleukin-22 OS=Homo sapiens OX=9606 GN=IL22 PE=1 SV=1" "0.010" "False" "2.344" "4" "1" "1" "1" "179" "20.0" "7.77" "2.30" "1" "stress response;signal transduction;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding" "Pf14565" "50616" "ENSG00000127318" "IL22" "hsa:50616; Q9GZX6" "Allograft rejection; Development and heterogeneity of the ILC family; Overview of proinflammatory and profibrotic mediators; Th17 cell differentiation pathway; Inflammatory bowel disease signaling" "Signaling by ALK fusions and activated point mutants; Interleukin-20 family signaling" "7" "0" "0.906" "1.072" "0.920" "0.851" "0.927" "0.938" "1.023" "0.955" "0.852" "248.8" "225.3" "266.8" "228.7" "211.8" "230.6" "233.4" "254.6" "237.5" "211.9" "" "" "" "" "" "" "" "" "" "" "223.7" "182.3" "241.3" "223.3" "174.7" "230.6" "174.7" "224.9" "212.5" "75.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7214058643654551286" "False" "High" "IsMasterProtein" "Q9Y3Y2" "Chromatin target of PRMT1 protein OS=Homo sapiens OX=9606 GN=CHTOP PE=1 SV=2" "0.010" "False" "2.339" "5" "1" "1" "1" "248" "26.4" "12.23" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "nucleus" "nucleic acid binding activity" "Pf13865" "26097" "ENSG00000160679" "CHTOP" "D3DV55; hsa:26097; Q0VAQ8; Q2VPI9; Q5T7Y8; Q5T7Y9; Q5T7Z0; Q6NSM4; Q6PB28; Q8WYT9; Q9BUC5; Q9H034; Q9H2L0; Q9Y3Y2" "" "mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Transport of Mature mRNA derived from an Intron-Containing Transcript" "3" "0" "1.713" "1.117" "1.382" "1.269" "0.861" "1.634" "1.210" "0.807" "1.535" "12.9" "22.1" "14.4" "17.8" "16.3" "11.1" "21.0" "15.6" "10.4" "19.8" "" "" "" "" "" "" "" "" "" "" "11.6" "17.9" "13.0" "17.4" "13.5" "11.1" "15.8" "13.8" "9.3" "7.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1223463018852322769" "False" "High" "IsMasterProtein" "Q96MX0" "CKLF-like MARVEL transmembrane domain-containing protein 3 OS=Homo sapiens OX=9606 GN=CMTM3 PE=1 SV=1" "0.010" "False" "2.331" "7" "1" "2" "1" "182" "19.7" "4.56" "2.35" "1" "developmental processes;signal transduction;other biological processes" "non-structural extracellular;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf01284" "123920" "ENSG00000140931" "CMTM3" "A6NCL9; hsa:123920; Q8IUU8; Q8IWQ6; Q8IYE2; Q8IZ39; Q8IZ59; Q96MX0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3125530162626484972" "False" "Medium" "IsMasterProtein" "Q9Y2L9" "Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LRCH1 PE=1 SV=3" "0.011" "False" "2.305" "2" "1" "2" "1" "728" "80.8" "5.94" "4.17" "1" "other biological processes" "other cell component" "" "Pf00307, Pf13855" "23143" "ENSG00000136141" "LRCH1" "B7ZLL5; F8W6F0; hsa:23143; Q17R43; Q2KHR1; Q5TBU9; Q7Z5F6; Q7Z5F7; Q9Y2L9" "" "" "0" "0" "0.788" "1.025" "0.687" "0.709" "0.683" "0.709" "0.714" "0.715" "0.620" "125.3" "98.7" "128.4" "86.2" "88.9" "85.6" "88.9" "89.5" "89.6" "77.7" "" "" "" "" "" "" "" "" "" "" "112.7" "79.9" "116.2" "84.1" "73.3" "85.6" "66.6" "79.0" "80.1" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5779285951144314922" "False" "Medium" "IsMasterProtein" "Q8IUH3" "RNA-binding protein 45 OS=Homo sapiens OX=9606 GN=RBM45 PE=1 SV=1" "0.011" "False" "2.304" "2" "1" "1" "1" "476" "53.5" "7.17" "2.41" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "129831" "ENSG00000155636" "RBM45" "hsa:129831; Q6NYL0; Q8IUH3; Q8NFC9" "" "" "0" "0" "1.109" "1.057" "1.381" "0.961" "0.727" "1.240" "1.083" "0.929" "2.466" "19.1" "21.1" "20.2" "26.3" "18.3" "13.9" "23.7" "20.7" "17.7" "47.0" "" "" "" "" "" "" "" "" "" "" "17.1" "17.1" "18.2" "25.7" "15.1" "13.9" "17.7" "18.2" "15.9" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9036966405367279656" "False" "Medium" "IsMasterProtein" "Q15506" "Sperm surface protein Sp17 OS=Homo sapiens OX=9606 GN=SPA17 PE=1 SV=1" "0.011" "False" "2.301" "6" "1" "1" "1" "151" "17.4" "4.78" "0.00" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00612, Pf02197" "53340" "ENSG00000064199" "SPA17" "B2R4F2; hsa:53340; Q15506; Q9BXF7" "" "" "0" "0" "0.959" "0.816" "0.823" "0.986" "0.950" "1.130" "0.945" "0.688" "0.998" "50.2" "48.2" "41.0" "41.3" "49.5" "47.7" "56.7" "47.4" "34.5" "50.1" "" "" "" "" "" "" "" "" "" "" "45.1" "39.0" "37.1" "40.3" "40.8" "47.7" "42.5" "41.9" "30.9" "17.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1103469562335054989" "False" "Medium" "IsMasterProtein" "Q8WUF8" "Cotranscriptional regulator ARB2A OS=Homo sapiens OX=9606 GN=ARB2A PE=1 SV=1" "0.011" "False" "2.297" "2" "1" "1" "1" "416" "47.9" "6.09" "2.32" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "ER/Golgi;nucleus" "" "Pf09757" "83989" "ENSG00000113391" "ARB2A" "B2R7C6; B4DJ14; B4DLG5; hsa:83989; Q8WUF8; Q9H0U8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1112026886534242272" "False" "Medium" "IsMasterProtein" "Q99653" "Calcineurin B homologous protein 1 OS=Homo sapiens OX=9606 GN=CHP1 PE=1 SV=3" "0.011" "False" "2.294" "6" "1" "1" "1" "195" "22.4" "5.10" "2.72" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "transporter activity;enzyme regulator activity;cytoskeletal activity;other molecular function" "Pf00036" "11261" "ENSG00000187446" "CHP1" "B2R6H9; hsa:11261; Q6FHZ9; Q99653" "T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection" "Hyaluronan uptake and degradation" "2" "0" "1.009" "0.963" "0.857" "1.065" "1.083" "0.915" "1.073" "1.040" "0.782" "74.4" "75.1" "71.7" "63.8" "79.3" "80.6" "68.1" "79.9" "77.4" "58.2" "" "" "" "" "" "" "" "" "" "" "66.9" "60.8" "64.9" "62.3" "65.4" "80.6" "51.0" "70.5" "69.3" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "354118340354877787" "False" "Medium" "IsMasterProtein" "P56962" "Syntaxin-17 OS=Homo sapiens OX=9606 GN=STX17 PE=1 SV=2" "0.012" "False" "2.261" "3" "1" "1" "1" "302" "33.4" "6.57" "3.31" "1" "cell organization and biogenesis;other metabolic processes;transport" "plasma membrane;other membranes;cytosol;mitochondrion;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "55014" "ENSG00000136874" "STX17" "hsa:55014; P56962; Q4VXC2" "" "COPII-mediated vesicle transport" "1" "0" "1.462" "1.241" "1.144" "1.137" "1.319" "1.003" "1.288" "1.320" "1.522" "13.1" "19.2" "16.3" "15.0" "14.9" "17.3" "13.2" "16.9" "17.3" "20.0" "" "" "" "" "" "" "" "" "" "" "11.8" "15.5" "14.7" "14.6" "12.3" "17.3" "9.9" "14.9" "15.5" "7.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8593755170917475749" "False" "Medium" "IsMasterProtein" "P53803" "DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Homo sapiens OX=9606 GN=POLR2K PE=1 SV=1" "0.012" "False" "2.254" "10" "1" "2" "1" "58" "7.0" "9.06" "4.99" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf03604" "5440" "ENSG00000147669" "POLR2K" "hsa:5440; P53803; Q6IBD4" "Pyrimidine metabolism; Eukaryotic transcription initiation; Cytosolic DNA-sensing pathway; 2q13 copy number variation syndrome" "Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; Pausing and recovery of Tat-mediated HIV elongation; Abortive elongation of HIV-1 transcript in the absence of Tat; Tat-mediated HIV elongation arrest and recovery; HIV elongation arrest and recovery; Pausing and recovery of HIV elongation; RNA Polymerase II Pre-transcription Events; TP53 Regulates Transcription of DNA Repair Genes; RNA polymerase II transcribes snRNA genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; Activation of anterior HOX genes in hindbrain development during early embryogenesis; mRNA Splicing - Major Pathway; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; Viral Messenger RNA Synthesis; Transcriptional regulation by small RNAs; B-WICH complex positively regulates rRNA expression; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Estrogen-dependent gene expression; RNA Polymerase III Transcription Termination; RNA Polymerase III Chain Elongation; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; MicroRNA (miRNA) biogenesis; PIWI-interacting RNA (piRNA) biogenesis; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; FGFR2 alternative splicing; mRNA Splicing - Minor Pathway; Processing of Capped Intron-Containing Pre-mRNA; Signaling by FGFR2 IIIa TM; Inhibition of DNA recombination at telomere" "57" "0" "1.017" "1.036" "0.995" "0.955" "1.089" "0.999" "1.088" "1.011" "1.048" "191.1" "194.3" "198.0" "190.3" "182.5" "208.1" "190.9" "207.9" "193.2" "200.3" "" "" "" "" "" "" "" "" "" "" "171.9" "157.2" "179.1" "185.7" "150.6" "208.1" "142.9" "183.6" "172.8" "71.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155133754937223753" "False" "Medium" "IsMasterProtein" "O43402" "ER membrane protein complex subunit 8 OS=Homo sapiens OX=9606 GN=EMC8 PE=1 SV=1" "0.012" "False" "2.247" "5" "1" "1" "1" "210" "23.8" "6.40" "3.81" "1" "cell organization and biogenesis" "other membranes;ER/Golgi;other cell component" "" "Pf03665" "10328" "ENSG00000131148" "EMC8" "C9JB21; hsa:10328; O43402" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5503658375786999201" "False" "Medium" "IsMasterProtein" "O95476" "CTD nuclear envelope phosphatase 1 OS=Homo sapiens OX=9606 GN=CTDNEP1 PE=1 SV=2" "0.012" "False" "2.244" "5" "1" "2" "1" "244" "28.4" "9.76" "2.61" "1" "cell-cell signaling;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf03031" "23399" "ENSG00000175826" "CTDNEP1" "D3DTN7; hsa:23399; O95476; Q96GQ9" "Development of ureteric collection system" "Depolymerization of the Nuclear Lamina" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3850938661228975130" "False" "Medium" "IsMasterProtein" "Q9NQ55" "Suppressor of SWI4 1 homolog OS=Homo sapiens OX=9606 GN=PPAN PE=1 SV=1" "0.013" "False" "2.225" "3" "1" "1" "1" "473" "53.2" "10.13" "2.62" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf04427" "56342; 692312" "ENSG00000130810" "PPAN" "C9J3F9; hsa:56342; hsa:692312; Q9BW97; Q9H170; Q9NQ55" "" "" "0" "0" "0.673" "0.696" "0.479" "0.648" "0.702" "0.796" "0.605" "0.567" "0.548" "51.0" "34.3" "35.5" "24.5" "33.0" "35.8" "40.6" "30.8" "28.9" "28.0" "" "" "" "" "" "" "" "" "" "" "45.9" "27.8" "32.1" "23.9" "27.3" "35.8" "30.4" "27.2" "25.9" "10.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5924667286913212153" "False" "Medium" "IsMasterProtein" "Q9Y484" "WD repeat domain phosphoinositide-interacting protein 4 OS=Homo sapiens OX=9606 GN=WDR45 PE=1 SV=1" "0.013" "False" "2.223" "2" "1" "1" "1" "360" "39.8" "7.14" "3.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;other biological processes" "other membranes;cytosol;other cell component" "other molecular function" "Pf21032" "11152" "ENSG00000196998; ENSG00000292221" "WDR45" "A6NGH5; B7WPI2; hsa:11152; Q5MNZ5; Q6IBS7; Q6NT94; Q96H03; Q9Y484" "Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; ADHD and autism (ASD) linked metabolic pathways and SNP" "Macroautophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8812488917525874775" "False" "Medium" "IsMasterProtein" "A0AVF1" "Intraflagellar transport protein 56 OS=Homo sapiens OX=9606 GN=IFT56 PE=1 SV=1" "0.013" "False" "2.220" "1" "1" "1" "1" "554" "64.1" "6.93" "3.03" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf12895" "79989" "ENSG00000105948" "IFT56" "A0AVF1; A4D1S3; B7Z5M0; C9J2N7; F8W724; hsa:79989; Q9H9S8; Q9NTC0" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR)" "Intraflagellar transport" "3" "0" "1.133" "1.222" "0.831" "1.244" "0.997" "0.994" "0.927" "1.142" "0.691" "43.8" "49.7" "53.6" "36.4" "54.5" "43.7" "43.6" "40.7" "50.1" "30.3" "" "" "" "" "" "" "" "" "" "" "39.4" "40.2" "48.5" "35.6" "45.0" "43.7" "32.6" "35.9" "44.8" "10.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7269919126570467546" "False" "Medium" "IsMasterProtein" "Q16514" "Transcription initiation factor TFIID subunit 12 OS=Homo sapiens OX=9606 GN=TAF12 PE=1 SV=1" "0.013" "False" "2.219" "5" "1" "1" "1" "161" "17.9" "7.99" "3.31" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03847" "6883" "ENSG00000120656" "TAF12" "D3DPM5; hsa:6883; Q15775; Q16514; Q5T077" "Eukaryotic transcription initiation" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; Regulation of TP53 Activity through Phosphorylation; HATs acetylate histones" "11" "0" "0.833" "1.017" "0.811" "0.891" "0.813" "0.886" "0.865" "0.832" "1.303" "93.1" "77.5" "94.7" "75.5" "82.9" "75.6" "82.4" "80.5" "77.4" "121.3" "" "" "" "" "" "" "" "" "" "" "83.7" "62.7" "85.6" "73.7" "68.4" "75.6" "61.7" "71.1" "69.2" "43.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3655720050561738715" "False" "Medium" "IsMasterProtein" "P29400" "Collagen alpha-5(IV) chain OS=Homo sapiens OX=9606 GN=COL4A5 PE=1 SV=2" "0.013" "False" "2.219" "1" "1" "1" "1" "1685" "160.9" "7.62" "0.00" "1" "cell organization and biogenesis;signal transduction" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "" "Pf01391, Pf01413" "1287" "ENSG00000188153" "COL4A5" "hsa:1287; P29400; Q16006; Q16126; Q6LD84; Q7Z700; Q9NUB7" "Primary focal segmental glomerulosclerosis (FSGS); PI3K-Akt signaling pathway; Epithelial to mesenchymal transition in colorectal cancer; Small cell lung cancer; Nephrotic syndrome; Pleural mesothelioma" "Regulation of expression of SLITs and ROBOs; Collagen degradation; Signaling by PDGF; Integrin cell surface interactions; ECM proteoglycans; NCAM1 interactions; Collagen chain trimerization; Non-integrin membrane-ECM interactions; Laminin interactions; Anchoring fibril formation; Crosslinking of collagen fibrils" "20" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-470190640123372826" "False" "Medium" "IsMasterProtein" "Q8WXD2" "Secretogranin-3 OS=Homo sapiens OX=9606 GN=SCG3 PE=1 SV=3" "0.013" "False" "2.216" "1" "1" "1" "1" "468" "53.0" "5.03" "2.96" "1" "other biological processes" "non-structural extracellular;other membranes;ER/Golgi;other cell component" "" "Pf15467" "29106" "ENSG00000104112" "SCG3" "A8K2B0; B3KQP6; B4DK99; F5H3R8; hsa:29106; Q8WXD2; Q96C83; Q96GE8; Q9Y6G7" "" "Platelet degranulation ; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3681874957149722431" "False" "Medium" "IsMasterProtein" "Q99558" "Mitogen-activated protein kinase kinase kinase 14 OS=Homo sapiens OX=9606 GN=MAP3K14 PE=1 SV=2" "0.013" "False" "2.214" "1" "1" "1" "1" "947" "104.0" "7.72" "2.90" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "9020" "ENSG00000006062" "MAP3K14" "A8K2D8; D3DX67; hsa:9020; Q8IYN1; Q99558" "Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; TNF-alpha signaling pathway; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Signal transduction through IL1R; Insulin signaling; Modulators of TCR signaling and T cell activation; GDNF signaling; T-cell receptor signaling pathway" "Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; CD28 dependent PI3K/Akt signaling; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway" "22" "0" "1.160" "0.910" "0.956" "0.980" "0.944" "1.143" "1.011" "1.039" "0.892" "231.5" "268.7" "210.7" "221.3" "226.9" "218.5" "264.6" "234.2" "240.5" "206.4" "" "" "" "" "" "" "" "" "" "" "208.2" "217.4" "190.5" "216.1" "187.2" "218.5" "198.1" "206.8" "215.2" "73.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6611035198024909537" "False" "Medium" "IsMasterProtein" "O43167" "Zinc finger and BTB domain-containing protein 24 OS=Homo sapiens OX=9606 GN=ZBTB24 PE=1 SV=2" "0.013" "False" "2.212" "1" "1" "1" "1" "697" "78.2" "7.61" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "9841" "ENSG00000112365" "ZBTB24" "hsa:9841; O43167; Q17RC6; Q5TED5; Q8N455" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1400083928917287466" "False" "Medium" "IsMasterProtein" "Q8TF40" "Folliculin-interacting protein 1 OS=Homo sapiens OX=9606 GN=FNIP1 PE=1 SV=3" "0.013" "False" "2.207" "1" "1" "1" "1" "1166" "130.5" "5.52" "2.79" "1" "stress response;signal transduction;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf14636, Pf14637, Pf14638" "96459" "ENSG00000217128" "FNIP1" "D6RJH5; hsa:96459; Q86T47; Q8TF40; Q9BUT0" "" "Amino acids regulate mTORC1" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5230078542330958363" "False" "Medium" "IsMasterProtein" "Q9NY15" "Stabilin-1 OS=Homo sapiens OX=9606 GN=STAB1 PE=1 SV=3" "0.013" "False" "2.200" "0" "1" "1" "1" "2570" "275.3" "6.49" "2.91" "1" "cell adhesion;cell-cell signaling;stress response;transport;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf00193, Pf02469, Pf12947" "23166" "ENSG00000010327" "STAB1" "A7E297; hsa:23166; Q8IUH0; Q8IUH1; Q93072; Q9NY15" "" "Scavenging by Class H Receptors" "1" "0" "1.316" "0.897" "0.808" "1.220" "1.038" "1.143" "1.083" "1.210" "0.694" "120.0" "158.0" "107.7" "97.0" "146.4" "124.6" "137.2" "130.0" "145.3" "83.3" "" "" "" "" "" "" "" "" "" "" "107.9" "127.8" "97.4" "94.7" "120.8" "124.6" "102.7" "114.9" "130.0" "29.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5036178333900895591" "False" "Medium" "IsMasterProtein" "Q5EBL8" "PDZ domain-containing protein 11 OS=Homo sapiens OX=9606 GN=PDZD11 PE=1 SV=2" "0.013" "False" "2.196" "6" "1" "1" "1" "140" "16.1" "7.21" "3.11" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;other cell component" "" "Pf00595" "51248" "ENSG00000120509" "PDZD11" "D3DVU3; hsa:51248; Q5EBL8; Q6UWE1; Q9P0Q1" "" "Ion transport by P-type ATPases; Ion influx/efflux at host-pathogen interface; Transport of vitamins, nucleosides, and related molecules; Biotin transport and metabolism; Vitamin B5 (pantothenate) metabolism" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6366471573816439068" "False" "Medium" "IsMasterProtein" "P52179" "Myomesin-1 OS=Homo sapiens OX=9606 GN=MYOM1 PE=1 SV=2" "0.013" "False" "2.191" "1" "1" "2" "1" "1685" "187.5" "6.93" "5.47" "1" "developmental processes;signal transduction;other biological processes" "cytoskeleton" "other molecular function" "Pf00041, Pf07679" "8736" "ENSG00000101605" "MYOM1" "hsa:8736; P52179; Q14BD6; Q6H969; Q6ZUU0" "Striated muscle contraction pathway" "" "1" "0" "0.965" "0.966" "1.024" "0.961" "0.738" "1.059" "1.030" "0.989" "0.867" "305.1" "294.4" "294.8" "312.3" "293.3" "225.2" "323.0" "314.2" "301.6" "264.4" "" "" "" "" "" "" "" "" "" "" "274.3" "238.2" "266.6" "304.9" "242.0" "225.2" "241.8" "277.5" "269.8" "94.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "562865633483991782" "False" "Medium" "IsMasterProtein" "Q9UBT7" "Alpha-catulin OS=Homo sapiens OX=9606 GN=CTNNAL1 PE=1 SV=2" "0.013" "False" "2.187" "2" "1" "1" "1" "734" "81.8" "6.64" "2.48" "1" "cell adhesion;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf01044" "8727" "ENSG00000119326" "CTNNAL1" "B5BU47; hsa:8727; O76084; Q53FQ2; Q5JTQ7; Q5JTQ8; Q9UBT7; Q9Y401" "" "" "0" "0" "1.130" "1.190" "0.983" "1.040" "0.973" "1.040" "1.145" "1.065" "1.235" "61.8" "69.9" "73.5" "60.8" "64.3" "60.1" "64.3" "70.8" "65.9" "76.3" "" "" "" "" "" "" "" "" "" "" "55.6" "56.5" "66.5" "59.3" "53.0" "60.1" "48.1" "62.5" "58.9" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3995888645862527253" "False" "Medium" "IsMasterProtein" "A4D1E9" "GTP-binding protein 10 OS=Homo sapiens OX=9606 GN=GTPBP10 PE=1 SV=1" "0.013" "False" "2.181" "2" "1" "2" "1" "387" "42.9" "9.03" "4.89" "1" "other biological processes" "mitochondrion;nucleus;other cell component" "other molecular function" "Pf01018, Pf01926" "85865" "ENSG00000105793" "GTPBP10" "A4D1E9; B4DFY6; hsa:85865; Q3B7A6; Q5H9V2; Q8IXG8; Q8N982; Q8WU16; Q9BSP1; Q9Y6T6" "" "" "0" "0" "1.051" "0.914" "0.915" "1.153" "0.870" "0.979" "0.877" "0.809" "1.044" "70.6" "74.3" "64.6" "64.6" "81.4" "61.4" "69.2" "61.9" "57.1" "73.8" "" "" "" "" "" "" "" "" "" "" "63.5" "60.1" "58.4" "63.1" "67.2" "61.4" "51.8" "54.7" "51.1" "26.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7295349075853767630" "False" "Medium" "IsMasterProtein" "Q1MSJ5" "Centrosome and spindle pole-associated protein 1 OS=Homo sapiens OX=9606 GN=CSPP1 PE=1 SV=4" "0.013" "False" "2.180" "1" "1" "1" "1" "1256" "145.4" "6.80" "2.22" "1" "other biological processes" "cytoskeleton;other cell component" "" "" "79848" "ENSG00000104218" "CSPP1" "A6ND63; hsa:79848; Q1MSJ5; Q70F00; Q8TBC1" "Joubert syndrome; Ciliopathies" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6714422319878504399" "False" "Medium" "IsMasterProtein" "O95391" "Pre-mRNA-splicing factor SLU7 OS=Homo sapiens OX=9606 GN=SLU7 PE=1 SV=2" "0.014" "False" "2.177" "1" "1" "1" "1" "586" "68.3" "7.14" "2.69" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;transport" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf11708" "10569" "ENSG00000164609" "SLU7" "D3DQK2; hsa:10569; O95391; Q3LUJ0; Q3LUJ1; Q6RXQ5; Q96FM9" "" "mRNA Splicing - Major Pathway; Transport of Mature mRNA derived from an Intron-Containing Transcript; mRNA 3'-end processing; RNA Polymerase II Transcription Termination" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230777369959258810" "False" "Medium" "IsMasterProtein" "O95239" "Chromosome-associated kinesin KIF4A OS=Homo sapiens OX=9606 GN=KIF4A PE=1 SV=3" "0.014" "False" "2.176" "1" "1" "1" "1" "1232" "139.8" "6.27" "2.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "24137" "ENSG00000090889" "KIF4A" "B2R7V5; D3DVU4; hsa:24137; O95239; Q86TN3; Q86XX7; Q9NNY6; Q9NY24; Q9UMW3" "Retinoblastoma gene in cancer" "Recycling pathway of L1; COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Kinesins" "5" "0" "0.910" "1.055" "0.957" "0.982" "1.048" "0.964" "1.167" "0.977" "2.962" "73.3" "66.7" "77.3" "70.1" "71.9" "76.7" "70.6" "85.5" "71.6" "217.0" "" "" "" "" "" "" "" "" "" "" "65.9" "54.0" "69.9" "68.5" "59.4" "76.7" "52.9" "75.5" "64.0" "77.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8507152288642739619" "False" "Medium" "IsMasterProtein" "Cont_P02668" "Kappa-casein OS=Bos taurus OX=9913 GN=CSN3 PE=1 SV=1" "0.014" "True" "2.175" "9" "1" "1" "1" "190" "21.3" "6.77" "2.13" "1" "transport;other biological processes" "non-structural extracellular;ER/Golgi" "other molecular function" "Pf00997" "281728" "" "CSN3" "bta:281728; O46566; P02668; Q597F3; Q6U205; Q9N271; Q9TRQ3; Q9TV96; Q9TV97" "" "" "0" "0" "0.878" "0.894" "0.669" "0.996" "2.852" "0.939" "0.988" "0.839" "0.732" "48.9" "42.9" "43.7" "32.7" "48.7" "139.5" "45.9" "48.3" "41.0" "35.8" "" "" "" "" "" "" "" "" "" "" "44.0" "34.7" "39.6" "31.9" "40.2" "139.5" "34.4" "42.7" "36.7" "12.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-446941790407473810" "False" "Medium" "IsMasterProtein" "Q17RP2" "Tigger transposable element-derived protein 6 OS=Homo sapiens OX=9606 GN=TIGD6 PE=1 SV=2" "0.014" "False" "2.168" "1" "1" "1" "1" "521" "58.6" "6.80" "2.13" "1" "" "nucleus" "nucleic acid binding activity" "Pf03184, Pf03221, Pf04218" "81789" "ENSG00000164296" "TIGD6" "B3KTZ8; hsa:81789; Q17RP2; Q96MQ4; Q9H0X7" "" "" "0" "0" "0.979" "0.970" "0.888" "1.089" "0.957" "1.090" "0.975" "0.967" "0.854" "218.6" "214.0" "212.0" "194.1" "238.0" "209.1" "238.2" "213.2" "211.5" "186.6" "" "" "" "" "" "" "" "" "" "" "196.5" "173.2" "191.8" "189.4" "196.4" "209.1" "178.4" "188.3" "189.2" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2982009215915538431" "False" "Medium" "IsMasterProtein" "Q8TBA6" "Golgin subfamily A member 5 OS=Homo sapiens OX=9606 GN=GOLGA5 PE=1 SV=3" "0.014" "False" "2.161" "2" "1" "1" "1" "731" "83.0" "5.83" "2.69" "1" "cell organization and biogenesis;transport" "other membranes;ER/Golgi" "other molecular function" "Pf09787" "9950" "ENSG00000066455" "GOLGA5" "C9JRU1; hsa:9950; O95287; Q03962; Q2TS49; Q8TBA6; Q9UQQ7" "" "Intra-Golgi traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-832675095304565644" "False" "Medium" "IsMasterProtein" "Q8IY26" "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6 OS=Homo sapiens OX=9606 GN=PLPP6 PE=1 SV=3" "0.014" "False" "2.157" "3" "1" "1" "1" "295" "32.2" "9.99" "2.58" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus" "other molecular function" "Pf01569" "403313" "ENSG00000205808" "PLPP6" "B3KY05; hsa:403313; Q5JVJ6; Q8IY26; Q8NCK9" "" "Cholesterol biosynthesis" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-265901885640742242" "False" "Medium" "IsMasterProtein" "Q03164" "Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5" "0.014" "False" "2.148" "0" "1" "1" "1" "3969" "431.5" "9.09" "3.74" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf02008, Pf05964, Pf05965, Pf13771" "4297" "ENSG00000118058" "KMT2A" "E9PQG7; hsa:4297; Q03164; Q13743; Q13744; Q14845; Q16364; Q59FF2; Q6UBD1; Q9HBJ3; Q9UD94; Q9UMA3" "Histone modifications" "RUNX1 regulates transcription of genes involved in differentiation of HSCs; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Transcriptional regulation of granulopoiesis" "6" "0" "1.099" "1.062" "0.939" "1.000" "1.059" "1.081" "0.950" "0.941" "1.347" "215.9" "237.3" "229.3" "202.8" "216.0" "228.6" "233.4" "205.1" "203.2" "290.8" "" "" "" "" "" "" "" "" "" "" "194.1" "192.0" "207.4" "198.0" "178.3" "228.6" "174.8" "181.2" "181.8" "103.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3893915452985841051" "False" "Medium" "IsMasterProtein" "Q9Y3T9" "Nucleolar complex protein 2 homolog OS=Homo sapiens OX=9606 GN=NOC2L PE=1 SV=4" "0.014" "False" "2.148" "2" "1" "1" "1" "749" "84.9" "5.62" "2.36" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf03715" "26155" "ENSG00000188976" "NOC2L" "hsa:26155; Q5SVA3; Q9BTN6; Q9Y3T9" "1p36 copy number variation syndrome" "Regulation of TP53 Activity through Phosphorylation" "2" "0" "0.918" "1.303" "0.927" "1.077" "1.374" "0.897" "1.129" "1.055" "1.143" "54.6" "50.1" "71.1" "50.6" "58.8" "75.0" "49.0" "61.6" "57.6" "62.4" "" "" "" "" "" "" "" "" "" "" "49.1" "40.6" "64.3" "49.4" "48.5" "75.0" "36.7" "54.4" "51.6" "22.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1541658205894384730" "False" "Medium" "IsMasterProtein" "Q8N8R7" "ARL14 effector protein OS=Homo sapiens OX=9606 GN=ARL14EP PE=1 SV=1" "0.014" "False" "2.145" "3" "1" "1" "1" "260" "29.3" "8.07" "3.41" "1" "" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf14949" "120534" "ENSG00000152219" "ARL14EP" "hsa:120534; Q5HYH9; Q8N8R7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6257292579144491246" "False" "Medium" "IsMasterProtein" "Q92544" "Transmembrane 9 superfamily member 4 OS=Homo sapiens OX=9606 GN=TM9SF4 PE=1 SV=2" "0.015" "False" "2.144" "2" "1" "1" "1" "642" "74.5" "6.54" "0.00" "1" "cell adhesion;cell organization and biogenesis;stress response;transport;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf02990" "9777" "ENSG00000101337" "TM9SF4" "B0QYT7; hsa:9777; Q92544; Q9NUA3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1923861490419149454" "False" "Medium" "IsMasterProtein" "Q86UA6" "RPA-interacting protein OS=Homo sapiens OX=9606 GN=RPAIN PE=1 SV=2" "0.015" "False" "2.143" "4" "1" "1" "1" "219" "24.8" "4.87" "3.35" "1" "transport;other biological processes" "nucleus;other cell component" "other molecular function" "Pf14766, Pf14767, Pf14768" "84268" "ENSG00000129197" "RPAIN" "A0A0B4J1T3; B4DI36; B4DTX7; E9PDG9; E9PES3; J3KNH8; Q4G2Y0; Q4G2Y5; Q4G2Y8; Q6B4V9; Q6B4W0; Q6B4W1; Q6B4W4; Q86UA6; Q86X49; Q9BT00" "" "" "0" "0" "0.999" "0.976" "0.963" "1.013" "0.979" "1.109" "1.002" "0.997" "1.018" "139.6" "139.5" "136.2" "134.4" "141.4" "136.7" "154.8" "139.9" "139.1" "142.1" "" "" "" "" "" "" "" "" "" "" "125.5" "112.9" "123.2" "131.2" "116.7" "136.7" "115.9" "123.6" "124.5" "50.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2238397026184103268" "False" "Medium" "IsMasterProtein" "Q9ULU4" "MYND-type zinc finger-containing chromatin reader ZMYND8 OS=Homo sapiens OX=9606 GN=ZMYND8 PE=1 SV=2" "0.015" "False" "2.142" "1" "1" "1" "1" "1186" "131.6" "7.20" "2.99" "1" "cell organization and biogenesis;DNA metabolism;stress response;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00439, Pf00628, Pf00855, Pf12064" "23613" "ENSG00000101040" "ZMYND8" "B3KVL2; B7Z2A8; B7Z3E0; B7Z680; B7ZM62; E1P5U5; F5H0X3; H7C0U2; hsa:23613; J3KPU3; Q13517; Q2HXV1; Q2HXV2; Q2HXV3; Q2HXV4; Q2HXV7; Q2HXV8; Q2HXV9; Q2HXW0; Q2HXW1; Q2HXW2; Q4JJ94; Q4JJ95; Q5TH09; Q5TH11; Q6MZM1; Q8WXC5; Q9H1F3; Q9H1F4; Q9H1F5; Q9H1L8; Q9H1L9; Q9H2G5; Q9NYN3; Q9UIX6; Q9ULU4" "" "" "0" "0" "1.087" "1.075" "0.940" "0.944" "0.852" "1.080" "1.011" "0.773" "1.785" "58.9" "64.0" "63.3" "55.3" "55.5" "50.2" "63.6" "59.5" "45.5" "105.1" "" "" "" "" "" "" "" "" "" "" "52.9" "51.7" "57.2" "54.0" "45.8" "50.2" "47.6" "52.6" "40.7" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2569459131829985106" "False" "Medium" "IsMasterProtein" "Q8TAC1" "Rieske domain-containing protein OS=Homo sapiens OX=9606 GN=RFESD PE=1 SV=1" "0.015" "False" "2.142" "6" "1" "1" "1" "157" "17.8" "6.86" "3.12" "1" "" "" "other molecular function" "Pf00355" "317671" "ENSG00000175449" "RFESD" "hsa:317671; J3KPH1; Q8TAC1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8588512168019091393" "False" "Medium" "IsMasterProtein" "Q5FWF5" "N-acetyltransferase ESCO1 OS=Homo sapiens OX=9606 GN=ESCO1 PE=1 SV=3" "0.015" "False" "2.141" "1" "1" "1" "1" "840" "94.9" "9.16" "2.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf13878, Pf13880" "114799" "ENSG00000141446" "ESCO1" "B0YJ11; B0YJ12; hsa:114799; Q5FWF5; Q69YG4; Q69YS3; Q6IMD7; Q8N3Z5; Q8NBG2; Q96PX7" "Cohesin complex - Cornelia de Lange syndrome" "Establishment of Sister Chromatid Cohesion" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6209481463683659801" "False" "Medium" "IsMasterProtein" "Q71F23" "Centromere protein U OS=Homo sapiens OX=9606 GN=CENPU PE=1 SV=1" "0.015" "False" "2.140" "2" "1" "1" "1" "418" "47.5" "9.13" "2.81" "1" "cell cycle OR cell proliferation;developmental processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf13097" "79682" "ENSG00000151725" "CENPU" "A2RRD9; hsa:79682; Q09GN2; Q32Q71; Q71F23; Q9H5G1" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Deposition of new CENPA-containing nucleosomes at the centromere; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2598464737050709238" "False" "Medium" "IsMasterProtein" "Q96LD8" "Sentrin-specific protease 8 OS=Homo sapiens OX=9606 GN=SENP8 PE=1 SV=1" "0.015" "False" "2.135" "3" "1" "1" "1" "212" "24.1" "5.97" "0.00" "1" "protein metabolism;other metabolic processes" "cytosol" "other molecular function" "Pf02902" "123228" "ENSG00000166192" "SENP8" "hsa:123228; Q96LD8; Q96QA4" "" "UCH proteinases; Neddylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1997120607862774840" "False" "Medium" "IsMasterProtein" "O00189" "AP-4 complex subunit mu-1 OS=Homo sapiens OX=9606 GN=AP4M1 PE=1 SV=2" "0.015" "False" "2.131" "3" "1" "1" "1" "453" "49.9" "7.20" "2.96" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00928, Pf01217" "9179" "ENSG00000221838" "AP4M1" "D6W5U1; hsa:9179; O00189; Q8WV65; Q9UHK9" "" "Lysosome Vesicle Biogenesis" "1" "0" "1.078" "0.914" "0.927" "1.234" "1.154" "1.079" "1.032" "1.069" "1.464" "40.2" "43.3" "36.7" "37.3" "49.6" "46.4" "43.4" "41.5" "43.0" "58.8" "" "" "" "" "" "" "" "" "" "" "36.1" "35.1" "33.2" "36.4" "40.9" "46.4" "32.5" "36.7" "38.5" "21.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3079825360121275387" "False" "Medium" "IsMasterProtein" "Q5SNV9" "Uncharacterized protein C1orf167 OS=Homo sapiens OX=9606 GN=C1orf167 PE=2 SV=3" "0.015" "False" "2.130" "1" "1" "3" "1" "1449" "160.4" "10.89" "6.47" "1" "" "" "" "Pf15736" "" "" "C1orf167" "A0A8I5KXP5; hsa:284498" "" "" "0" "0" "1.010" "0.926" "0.742" "1.028" "0.865" "0.686" "0.765" "1.095" "1.993" "38.3" "38.7" "35.5" "28.4" "39.4" "33.1" "26.3" "29.3" "41.9" "76.3" "" "" "" "" "" "" "" "" "" "" "34.4" "31.3" "32.1" "27.7" "32.5" "33.1" "19.7" "25.9" "37.5" "27.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1985777424174479704" "False" "Medium" "IsMasterProtein" "Q14669" "E3 ubiquitin-protein ligase TRIP12 OS=Homo sapiens OX=9606 GN=TRIP12 PE=1 SV=1" "0.015" "False" "2.121" "0" "1" "1" "1" "1992" "220.3" "8.48" "2.45" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus" "other molecular function" "Pf00632" "9320" "ENSG00000153827" "TRIP12" "D4HL82; Q14669; Q14CA3; Q14CF1; Q15644; Q53R87; Q53TE7" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5427058765005465503" "False" "Medium" "IsMasterProtein" "Q7Z6I8" "UPF0461 protein C5orf24 OS=Homo sapiens OX=9606 GN=C5orf24 PE=1 SV=1" "0.015" "False" "2.120" "6" "1" "2" "1" "188" "20.1" "9.85" "4.23" "1" "" "" "" "Pf17724" "134553" "ENSG00000181904" "C5orf24" "D3DQA7; hsa:134553; Q7Z6I8; Q86Y53; Q8N1T9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "445777244130660815" "False" "Medium" "IsMasterProtein" "Q76N32" "Centrosomal protein of 68 kDa OS=Homo sapiens OX=9606 GN=CEP68 PE=1 SV=2" "0.015" "False" "2.113" "2" "1" "1" "1" "757" "81.1" "5.16" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "23177" "ENSG00000011523" "CEP68" "B4DRQ1; D6W5F1; D6W5F2; hsa:23177; O60326; Q76N32; Q9BQ18; Q9UDM9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-4031307080017597315" "False" "Medium" "IsMasterProtein" "P18077" "Large ribosomal subunit protein eL33 OS=Homo sapiens OX=9606 GN=RPL35A PE=1 SV=2" "0.015" "False" "2.113" "6" "1" "1" "1" "110" "12.5" "11.06" "3.26" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01247" "6165" "ENSG00000182899" "RPL35A" "hsa:6165; P18077; Q08ES9; Q9BVN7" "Cytoplasmic ribosomal proteins" "L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Regulation of expression of SLITs and ROBOs; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7259467159663286133" "False" "Medium" "IsMasterProtein" "Q9Y5N6" "Origin recognition complex subunit 6 OS=Homo sapiens OX=9606 GN=ORC6 PE=1 SV=1" "0.015" "False" "2.111" "3" "1" "1" "1" "252" "28.1" "8.66" "2.74" "1" "DNA metabolism;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf05460" "23594" "ENSG00000091651" "ORC6" "B3KN89; hsa:23594; Q9Y5N6" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Assembly of the ORC complex at the origin of replication; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; CDC6 association with the ORC:origin complex" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2430041529144084070" "False" "Medium" "IsMasterProtein" "Q14CZ0" "HUWE1-associated protein modifying stress responses 1 OS=Homo sapiens OX=9606 GN=HAPSTR1 PE=1 SV=1" "0.015" "False" "2.106" "3" "1" "1" "1" "275" "30.9" "7.91" "2.38" "1" "other biological processes" "nucleus;other cell component" "other molecular function" "Pf15251" "29035" "ENSG00000182831" "HAPSTR1" "hsa:29035; Q14CZ0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4474106479109079676" "False" "Medium" "IsMasterProtein" "O00422" "Histone deacetylase complex subunit SAP18 OS=Homo sapiens OX=9606 GN=SAP18 PE=1 SV=1" "0.015" "False" "2.104" "5" "1" "1" "1" "153" "17.6" "9.35" "2.73" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf06487" "10284" "ENSG00000150459" "SAP18" "B2R494; hsa:10284; O00422; Q2TTR4; Q6IAW9; Q8N606; Q9UF14; X6RAL5" "Hedgehog signaling pathway" "Potential therapeutics for SARS; HDACs deacetylate histones; NoRC negatively regulates rRNA expression; mRNA Splicing - Major Pathway" "5" "0" "0.979" "1.062" "1.020" "1.056" "0.949" "1.310" "1.036" "0.987" "1.655" "165.0" "161.6" "175.2" "168.2" "174.2" "156.6" "216.1" "170.9" "162.9" "273.1" "" "" "" "" "" "" "" "" "" "" "148.3" "130.7" "158.5" "164.2" "143.7" "156.6" "161.8" "151.0" "145.8" "97.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4835806217438690237" "False" "Medium" "IsMasterProtein" "Q9Y2K5" "R3H domain-containing protein 2 OS=Homo sapiens OX=9606 GN=R3HDM2 PE=1 SV=3" "0.015" "False" "2.104" "1" "1" "1" "1" "976" "106.9" "8.85" "2.46" "1" "" "nucleus" "" "Pf01424" "22864" "ENSG00000179912" "R3HDM2" "B7ZL65; hsa:22864; Q2M1T9; Q3ZCT5; Q9Y2K5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-288326920404565316" "False" "Medium" "IsMasterProtein" "O15111" "Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Homo sapiens OX=9606 GN=CHUK PE=1 SV=2" "0.015" "False" "2.100" "1" "1" "1" "1" "745" "84.6" "6.73" "2.74" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf12179, Pf18397" "1147" "ENSG00000213341" "CHUK" "hsa:1147; O14666; O15111; Q13132; Q5W0I4; Q92467" "Nucleotide-binding oligomerization domain (NOD) pathway; Osteopontin signaling; MicroRNAs in cardiomyocyte hypertrophy; IL-1 signaling pathway; RANKL/RANK signaling pathway; Leptin signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; Alzheimer's disease and miRNA effects; B cell receptor signaling pathway; TNF-alpha signaling pathway; AGE/RAGE pathway; Interleukin-11 signaling pathway; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Ebstein-Barr virus LMP1 signaling; Interleukin-1 (IL-1) structural pathway; Cardiac hypertrophic response; Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4); Nod-like receptor (NLR) signaling pathway; RAC1/PAK1/p38/MMP2 pathway; Photodynamic therapy-induced NF-kB survival signaling; MAPK signaling pathway; Canonical and non-canonical Notch signaling; MAPK and NFkB signaling pathways inhibited by Yersinia YopJ; Toll-like receptor signaling related to MyD88; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Novel intracellular components of RIG-I-like receptor pathway; Chemokine signaling pathway; IL-4 signaling pathway; Fibrin complement receptor 3 signaling pathway; PI3K-Akt signaling pathway; Ras signaling; Pancreatic adenocarcinoma pathway; miRNA role in immune response in sepsis; Suppression of HMGB1-mediated inflammation by THBD; Altered glycosylation of MUC1 in tumor microenvironment; Resistin as a regulator of inflammation; Vitamin D in inflammatory diseases; Signal transduction through IL1R; Canonical NF-kB pathway; Measles virus infection; Cytosolic DNA-sensing pathway; Small cell lung cancer; Gastrin signaling pathway; Hepatitis B infection; IL-18 signaling pathway; Host-pathogen interaction of human coronaviruses - interferon induction; Neuroinflammation; STING pathway in Kawasaki-like disease and COVID-19; Modulators of TCR signaling and T cell activation; CCL18 signaling pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Alzheimer's disease; GDNF signaling; Acute myeloid leukemia; T-cell receptor signaling pathway; Estrogen signaling pathway; Toll-like receptor signaling pathway" "FCERI mediated NF-kB activation; Downstream TCR signaling; Activation of NF-kappaB in B cells; ER-Phagosome pathway; Dectin-1 mediated noncanonical NF-kB signaling; NIK-->noncanonical NF-kB signaling; PKR-mediated signaling; SARS-CoV-2 activates/modulates innate and adaptive immune responses; Constitutive Signaling by AKT1 E17K in Cancer; IKK complex recruitment mediated by RIP1; NOD1/2 Signaling Pathway; TICAM1, RIP1-mediated IKK complex recruitment; RIP-mediated NFkB activation via ZBP1; TAK1-dependent IKK and NF-kappa-B activation ; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; IKBKB deficiency causes SCID; IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR); IkBA variant leads to EDA-ID; MAP3K8 (TPL2)-dependent MAPK1/3 activation; TRAF6 mediated NF-kB activation; NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10; IRAK1 recruits IKK complex; IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation; Regulation of NF-kappa B signaling; AKT phosphorylates targets in the cytosol" "86" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7692886187860556609" "False" "Medium" "IsMasterProtein" "Q8N0U7" "Uncharacterized protein C1orf87 OS=Homo sapiens OX=9606 GN=C1orf87 PE=1 SV=1" "0.015" "False" "2.099" "1" "1" "1" "1" "546" "62.0" "8.65" "2.75" "1" "" "" "" "Pf17743, Pf20742, Pf20743" "127795" "ENSG00000162598" "C1orf87" "hsa:127795; Q6ZU07; Q8IVS0; Q8N0U7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6965431405701772987" "False" "Medium" "IsMasterProtein" "Q8N612" "FHF complex subunit HOOK-interacting protein 1B OS=Homo sapiens OX=9606 GN=FHIP1B PE=1 SV=3" "0.015" "False" "2.094" "1" "1" "1" "1" "972" "105.5" "6.77" "2.18" "1" "cell organization and biogenesis;transport;other biological processes" "cytosol;other cell component" "" "Pf10257, Pf19311, Pf19314" "84067" "ENSG00000051009" "FHIP1B" "hsa:84067; Q8N612; Q9C0A4; Q9H0N3; Q9H624" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4219783111601557579" "False" "Medium" "IsMasterProtein" "Q13216" "DNA excision repair protein ERCC-8 OS=Homo sapiens OX=9606 GN=ERCC8 PE=1 SV=1" "0.015" "False" "2.093" "2" "1" "1" "1" "396" "44.0" "6.35" "2.66" "1" "protein metabolism;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400" "1161" "ENSG00000049167" "ERCC8" "B2RB64; hsa:1161; Q13216; Q6FHX5; Q96GB9" "Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum ; 10q11.21q11.23 copy number variation syndrome" "Neddylation; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1125473546662306329" "False" "Medium" "IsMasterProtein" "Q13889" "General transcription factor IIH subunit 3 OS=Homo sapiens OX=9606 GN=GTF2H3 PE=1 SV=2" "0.015" "False" "2.089" "3" "1" "1" "1" "308" "34.4" "7.02" "2.99" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf03850" "2967" "ENSG00000111358" "GTF2H3" "B2R819; B4DNZ6; hsa:2967; Q13889; Q7L0G0; Q96AT7" "Eukaryotic transcription initiation; Nucleotide excision repair; DNA repair pathways, full network; Nucleotide excision repair in xeroderma pigmentosum" "RNA Polymerase II Pre-transcription Events; HIV Transcription Initiation; RNA Polymerase II HIV Promoter Escape; RNA Polymerase II Promoter Escape; RNA Polymerase II Transcription Pre-Initiation And Promoter Opening; RNA Polymerase II Transcription Initiation; NoRC negatively regulates rRNA expression; Formation of TC-NER Pre-Incision Complex; Dual incision in TC-NER; Gap-filling DNA repair synthesis and ligation in TC-NER; Formation of RNA Pol II elongation complex ; Formation of the Early Elongation Complex; Formation of HIV elongation complex in the absence of HIV Tat; Formation of the HIV-1 Early Elongation Complex; RNA Pol II CTD phosphorylation and interaction with CE during HIV infection; Formation of HIV-1 elongation complex containing HIV-1 Tat; TP53 Regulates Transcription of DNA Repair Genes; mRNA Capping; RNA Pol II CTD phosphorylation and interaction with CE; RNA Polymerase I Transcription Initiation; RNA Polymerase I Promoter Escape; RNA Polymerase I Transcription Termination; Formation of Incision Complex in GG-NER; Dual Incision in GG-NER" "33" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5043456387620106594" "False" "Medium" "IsMasterProtein" "Q86US8" "Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2" "0.015" "False" "2.085" "1" "1" "2" "1" "1419" "160.4" "7.05" "2.79" "1" "RNA metabolism OR transcription;other metabolic processes;transport;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10373, Pf10374, Pf13638" "23293" "ENSG00000070366" "SMG6" "B7Z874; hsa:23293; O94837; Q86US8; Q86VH6; Q9UF60" "" "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3859888159614048527" "False" "Medium" "IsMasterProtein" "Q9NRP4" "Succinate dehydrogenase assembly factor 3, mitochondrial OS=Homo sapiens OX=9606 GN=SDHAF3 PE=1 SV=1" "0.016" "False" "2.077" "9" "1" "1" "1" "125" "14.6" "9.07" "3.22" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "mitochondrion" "" "Pf13233" "57001" "ENSG00000196636" "SDHAF3" "A4D1J3; hsa:57001; Q75MD6; Q9NRP4" "Mitochondrial complex II assembly" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5020474961382465415" "False" "Medium" "IsMasterProtein" "Q9NXG6" "Transmembrane prolyl 4-hydroxylase OS=Homo sapiens OX=9606 GN=P4HTM PE=1 SV=2" "0.016" "False" "2.071" "3" "1" "1" "1" "502" "56.6" "6.06" "2.12" "1" "other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf13499, Pf13640" "54681" "ENSG00000178467" "P4HTM" "hsa:54681; Q6PAG6; Q8TCJ9; Q8WV55; Q96F22; Q9BW77; Q9NXG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6600262184831849925" "False" "Medium" "IsMasterProtein" "Q9P086" "Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2" "0.016" "False" "2.059" "6" "1" "2" "1" "117" "13.1" "5.96" "4.71" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf10280" "400569" "ENSG00000161920" "MED11" "hsa:400569; Q6NS89; Q9P086" "" "PPARA activates gene expression; Transcriptional regulation of white adipocyte differentiation; RSV-host interactions" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-829436805144986471" "False" "Medium" "IsMasterProtein" "P61927" "Large ribosomal subunit protein eL37 OS=Homo sapiens OX=9606 GN=RPL37 PE=1 SV=2" "0.016" "False" "2.055" "7" "1" "2" "1" "97" "11.1" "11.74" "5.50" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;translational apparatus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf01907" "6167" "ENSG00000145592" "RPL37" "B2R4H2; hsa:6167; P02403; P61927; Q6IBB4; Q99883" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis" "14" "0" "1.011" "0.973" "1.016" "1.131" "1.120" "1.211" "1.078" "1.011" "1.162" "592.2" "598.9" "576.2" "601.7" "669.5" "663.0" "717.0" "638.4" "598.6" "688.0" "" "" "" "" "" "" "" "" "" "" "532.5" "484.6" "521.2" "587.3" "552.5" "663.0" "536.9" "563.8" "535.6" "245.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-728003267780759381" "False" "Medium" "IsMasterProtein" "Q8WV07" "Protein LTO1 homolog OS=Homo sapiens OX=9606 GN=LTO1 PE=1 SV=2" "0.017" "False" "2.042" "7" "1" "1" "1" "137" "15.3" "5.80" "0.00" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "nucleus" "" "Pf09811" "220064" "ENSG00000149716" "LTO1" "B2R4R2; hsa:220064; Q8NFK0; Q8WV07" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8622361133611111311" "False" "Medium" "IsMasterProtein" "O14936" "Peripheral plasma membrane protein CASK OS=Homo sapiens OX=9606 GN=CASK PE=1 SV=3" "0.017" "False" "2.039" "1" "1" "1" "1" "926" "105.1" "6.43" "2.53" "1" "cell adhesion;other metabolic processes;transport;other biological processes" "extracellular matrix;plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf00069, Pf00595, Pf00625, Pf02828, Pf07653" "8573" "ENSG00000147044" "CASK" "A6NES1; B7ZKY0; hsa:8573; O14936; O43215; Q17RI4; Q59HA0; Q5VT16; Q5VT17; Q5VT18; Q5VT19; Q66T42; Q9BYH6; Q9NYB2; Q9NYB3" "Parkin-ubiquitin proteasomal system pathway; Splicing factor NOVA regulated synaptic proteins; Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea; Assembly and cell surface presentation of NMDA receptors; Nephrin family interactions; Neurexins and neuroligins; Dopamine Neurotransmitter Release Cycle; Syndecan interactions" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7925293955382701162" "False" "Medium" "IsMasterProtein" "Q96JN8" "Neuralized-like protein 4 OS=Homo sapiens OX=9606 GN=NEURL4 PE=1 SV=2" "0.017" "False" "2.030" "1" "1" "1" "1" "1562" "166.8" "5.86" "2.89" "1" "" "cytoskeleton;other cell component" "other molecular function" "Pf07177" "84461" "ENSG00000215041; ENSG00000288301" "NEURL4" "hsa:84461; Q6GPI8; Q96IU9; Q96JN8; Q9H0B0" "" "" "0" "0" "0.777" "0.806" "0.817" "0.623" "1.035" "0.882" "0.900" "0.974" "1.366" "29.4" "22.8" "23.7" "24.0" "18.3" "30.4" "25.9" "26.4" "28.6" "40.1" "" "" "" "" "" "" "" "" "" "" "26.4" "18.5" "21.4" "23.4" "15.1" "30.4" "19.4" "23.4" "25.6" "14.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2271404358644786379" "False" "Medium" "IsMasterProtein" "P46778" "Large ribosomal subunit protein eL21 OS=Homo sapiens OX=9606 GN=RPL21 PE=1 SV=2" "0.017" "False" "2.020" "4" "1" "1" "1" "160" "18.6" "10.49" "3.05" "1" "protein metabolism;other metabolic processes" "cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf01157" "6144" "ENSG00000122026" "RPL21" "hsa:6144; P46778; Q16699" "Cytoplasmic ribosomal proteins" "Response of EIF2AK4 (GCN2) to amino acid deficiency; Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Formation of a pool of free 40S subunits; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8192588506631613460" "False" "Medium" "IsMasterProtein" "Q9Y239" "Nucleotide-binding oligomerization domain-containing protein 1 OS=Homo sapiens OX=9606 GN=NOD1 PE=1 SV=1" "0.017" "False" "2.016" "1" "1" "1" "1" "953" "107.6" "7.11" "2.53" "1" "other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cell component" "enzyme regulator activity;other molecular function" "Pf00619, Pf05729, Pf13516, Pf17776, Pf17779" "10392" "ENSG00000106100" "NOD1" "B4DTU3; hsa:10392; Q549U4; Q8IWF5; Q9Y239" "Nucleotide-binding oligomerization domain (NOD) pathway; Burn wound healing" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Ovarian tumor domain proteases; JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1; NOD1/2 Signaling Pathway; TAK1-dependent IKK and NF-kappa-B activation ; activated TAK1 mediates p38 MAPK activation" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3483870815456167383" "False" "Medium" "IsMasterProtein" "Q9NS28" "Regulator of G-protein signaling 18 OS=Homo sapiens OX=9606 GN=RGS18 PE=1 SV=1" "0.017" "False" "2.016" "4" "1" "1" "1" "235" "27.6" "7.91" "3.13" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;other molecular function" "Pf00615" "64407" "ENSG00000150681" "RGS18" "B2RD23; hsa:64407; Q9NS28" "Myometrial relaxation and contraction pathways; Calcium regulation in cardiac cells" "G alpha (q) signalling events; G alpha (i) signalling events" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6910924152517685584" "False" "Medium" "IsMasterProtein" "P13612" "Integrin alpha-4 OS=Homo sapiens OX=9606 GN=ITGA4 PE=1 SV=3" "0.017" "False" "2.010" "1" "1" "1" "1" "1032" "114.8" "6.48" "3.02" "1" "cell adhesion;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf01839, Pf08441, Pf20805, Pf20806" "3676" "ENSG00000115232" "ITGA4" "D3DPG4; hsa:3676; P13612; Q7Z4L6" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Ebola virus infection in host; Cells and molecules involved in local acute inflammatory response ; Pleural mesothelioma; 11p11.2 copy number variation syndrome" "Cell surface interactions at the vascular wall; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Potential therapeutics for SARS; Integrin cell surface interactions; RUNX3 Regulates Immune Response and Cell Migration" "14" "0" "1.050" "0.914" "0.995" "1.020" "0.985" "0.933" "0.954" "1.085" "0.979" "225.6" "236.9" "206.2" "224.6" "230.1" "222.1" "210.4" "215.1" "244.8" "220.8" "" "" "" "" "" "" "" "" "" "" "202.8" "191.7" "186.6" "219.2" "189.9" "222.1" "157.5" "190.0" "219.1" "78.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2299489419539549984" "False" "Medium" "IsMasterProtein" "Q9HCE3" "Zinc finger protein 532 OS=Homo sapiens OX=9606 GN=ZNF532 PE=1 SV=2" "0.017" "False" "2.002" "1" "1" "1" "1" "1301" "141.6" "8.65" "2.76" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf13912, Pf16622" "55205" "ENSG00000074657" "ZNF532" "hsa:55205; Q4G0V6; Q7L7Z7; Q96QR7; Q9HCE3; Q9NVJ6" "" "" "0" "0" "1.097" "0.997" "0.910" "1.013" "1.151" "0.959" "1.172" "1.198" "0.393" "117.9" "129.4" "117.5" "107.2" "119.4" "135.7" "113.0" "138.2" "141.2" "46.3" "" "" "" "" "" "" "" "" "" "" "106.0" "104.7" "106.3" "104.7" "98.5" "135.7" "84.6" "122.0" "126.3" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-181287195693513573" "False" "Medium" "IsMasterProtein" "Q96EA4" "Protein Spindly OS=Homo sapiens OX=9606 GN=SPDL1 PE=1 SV=2" "0.018" "False" "2.001" "2" "1" "1" "1" "605" "70.1" "5.47" "3.09" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "54908" "ENSG00000040275" "SPDL1" "B4E393; C9JS47; hsa:54908; Q8TEC8; Q96EA4; Q9HD44; Q9NX97" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6351982484354438023" "False" "Medium" "IsMasterProtein" "Q96E14" "RecQ-mediated genome instability protein 2 OS=Homo sapiens OX=9606 GN=RMI2 PE=1 SV=2" "0.018" "False" "2.000" "6" "1" "1" "1" "147" "15.9" "7.90" "2.27" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf16100" "116028" "ENSG00000175643" "RMI2" "B3KVZ6; hsa:116028; Q49AE2; Q8TBL0; Q96E14" "" "Resolution of D-loop Structures through Holliday Junction Intermediates; Regulation of TP53 Activity through Phosphorylation; Processing of DNA double-strand break ends; Presynaptic phase of homologous DNA pairing and strand exchange; G2/M DNA damage checkpoint; Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA); Defective homologous recombination repair (HRR) due to BRCA1 loss of function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function; Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function; Impaired BRCA2 binding to PALB2; HDR through Single Strand Annealing (SSA); Impaired BRCA2 binding to RAD51" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5403198551536365946" "False" "Medium" "IsMasterProtein" "Q14692" "Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens OX=9606 GN=BMS1 PE=1 SV=1" "0.018" "False" "1.999" "1" "1" "1" "1" "1282" "145.7" "6.44" "2.94" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04950, Pf08142" "9790" "ENSG00000165733" "BMS1" "hsa:9790; Q14692; Q5QPT5; Q86XJ9" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "0.870" "0.766" "1.014" "0.832" "0.795" "0.759" "0.871" "0.514" "0.600" "67.8" "59.0" "51.9" "68.8" "56.4" "53.9" "51.5" "59.0" "34.9" "40.7" "" "" "" "" "" "" "" "" "" "" "60.9" "47.7" "46.9" "67.1" "46.5" "53.9" "38.5" "52.1" "31.2" "14.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2484461728498550369" "False" "Medium" "IsMasterProtein" "Q5VWN6" "Protein TASOR 2 OS=Homo sapiens OX=9606 GN=TASOR2 PE=1 SV=1" "0.018" "False" "1.997" "0" "1" "1" "1" "2430" "268.7" "5.90" "0.00" "1" "cell organization and biogenesis" "cytosol;nucleus" "" "Pf12480, Pf12509" "54906" "ENSG00000108021" "TASOR2" "hsa:54906; Q2YD91; Q5VWN5; Q5VWN6; Q6ZRQ8; Q8IVG4; Q9BUZ7; Q9H5J9; Q9H7A4; Q9H996; Q9NXA1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8595761277015332679" "False" "Medium" "IsMasterProtein" "Q5TA50" "Ceramide-1-phosphate transfer protein OS=Homo sapiens OX=9606 GN=CPTP PE=1 SV=1" "0.018" "False" "1.996" "5" "1" "1" "1" "214" "24.4" "7.21" "1.94" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf08718" "80772" "ENSG00000224051" "CPTP" "hsa:80772; Q4G0E6; Q5TA50; Q7L5A4" "1p36 copy number variation syndrome" "Glycosphingolipid transport" "2" "0" "0.937" "1.056" "1.185" "1.194" "1.208" "1.215" "0.957" "1.043" "1.277" "39.1" "36.7" "41.3" "46.4" "46.7" "47.3" "47.5" "37.5" "40.8" "50.0" "" "" "" "" "" "" "" "" "" "" "35.2" "29.7" "37.4" "45.3" "38.5" "47.3" "35.6" "33.1" "36.5" "17.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3435210294334929693" "False" "Medium" "IsMasterProtein" "Q53HV7" "Single-strand selective monofunctional uracil DNA glycosylase OS=Homo sapiens OX=9606 GN=SMUG1 PE=1 SV=2" "0.019" "False" "1.993" "4" "1" "2" "1" "270" "29.8" "6.62" "4.16" "1" "DNA metabolism;other metabolic processes;stress response" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf03167" "23583" "ENSG00000123415" "SMUG1" "A8K2K9; hsa:23583; O95862; Q0D2M0; Q53HV7; Q8NB71; Q9BWC8" "Fluoropyrimidine activity; Base excision repair; DNA repair pathways, full network" "Recognition and association of DNA glycosylase with site containing an affected pyrimidine; Cleavage of the damaged pyrimidine ; Displacement of DNA glycosylase by APEX1" "6" "0" "4.118" "1.310" "0.696" "4.721" "4.203" "3.179" "1.249" "3.665" "2.273" "48.9" "201.5" "64.1" "34.1" "231.0" "205.6" "155.5" "61.1" "179.3" "111.2" "" "" "" "" "" "" "" "" "" "" "44.0" "163.1" "58.0" "33.3" "190.6" "205.6" "116.5" "54.0" "160.4" "39.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5340493121731341937" "False" "Medium" "IsMasterProtein" "Q9BQD3" "KxDL motif-containing protein 1 OS=Homo sapiens OX=9606 GN=KXD1 PE=1 SV=2" "0.019" "False" "1.991" "4" "1" "1" "1" "176" "19.7" "4.89" "2.75" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "Pf10241" "79036" "ENSG00000105700" "KXD1" "O76098; Q9BQD3" "" "" "0" "0" "0.833" "0.830" "0.907" "1.043" "0.916" "0.923" "0.928" "0.883" "0.856" "101.2" "84.3" "84.0" "91.7" "105.5" "92.7" "93.4" "93.8" "89.3" "86.6" "" "" "" "" "" "" "" "" "" "" "91.0" "68.2" "76.0" "89.5" "87.1" "92.7" "70.0" "82.9" "79.9" "30.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3107820624180600590" "False" "Medium" "IsMasterProtein" "O75879" "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1" "0.019" "False" "1.988" "1" "1" "1" "1" "557" "61.8" "8.63" "2.44" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "other molecular function" "Pf02637, Pf02934" "5188" "ENSG00000059691" "GATB" "hsa:5188; O75879; Q4W5M8; Q53GP4; Q9P0S6; Q9Y2B8" "" "" "0" "0" "1.062" "1.111" "0.977" "1.067" "0.979" "1.168" "1.114" "1.150" "2.167" "117.0" "124.2" "130.0" "114.3" "124.9" "114.6" "136.7" "130.4" "134.5" "253.6" "" "" "" "" "" "" "" "" "" "" "105.2" "100.5" "117.6" "111.6" "103.1" "114.6" "102.4" "115.1" "120.4" "90.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-558123854444436509" "False" "Medium" "IsMasterProtein" "Q9P2G4" "Microtubule-associated protein 10 OS=Homo sapiens OX=9606 GN=MAP10 PE=1 SV=2" "0.019" "False" "1.986" "2" "1" "1" "1" "905" "100.3" "7.17" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf14924, Pf14925" "54627" "ENSG00000212916" "MAP10" "A8K2F1; hsa:54627; Q32MI1; Q58EZ9; Q5VV83; Q9P2G4" "" "" "0" "0" "0.936" "1.013" "0.756" "0.724" "0.791" "0.825" "0.841" "0.788" "0.827" "75.9" "71.0" "76.9" "57.4" "54.9" "60.1" "62.6" "63.9" "59.8" "62.8" "" "" "" "" "" "" "" "" "" "" "68.3" "57.5" "69.6" "56.1" "45.3" "60.1" "46.9" "56.4" "53.5" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4593935513655895610" "False" "Medium" "IsMasterProtein" "Q13614" "Myotubularin-related protein 2 OS=Homo sapiens OX=9606 GN=MTMR2 PE=1 SV=4" "0.019" "False" "1.984" "1" "1" "1" "1" "643" "73.3" "7.40" "2.44" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02893, Pf06602" "8898" "ENSG00000087053" "MTMR2" "A6NN98; hsa:8898; Q13614; Q9UPS9" "Intracellular trafficking proteins involved in CMT neuropathy" "Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane; Synthesis of PIPs at the ER membrane" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4635662456929640047" "False" "Medium" "IsMasterProtein" "O15304" "Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2" "0.019" "False" "1.984" "5" "1" "1" "1" "175" "18.7" "7.61" "2.97" "1" "cell organization and biogenesis;transport;signal transduction;other biological processes" "mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf05458" "10572" "ENSG00000184990" "SIVA1" "hsa:10572; O15304; Q96P98; Q9UPD6" "p53 transcriptional gene network" "" "1" "0" "1.049" "1.241" "0.859" "0.864" "1.556" "1.133" "1.092" "1.432" "1.374" "97.5" "102.3" "121.0" "83.7" "84.3" "151.7" "110.4" "106.5" "139.6" "134.0" "" "" "" "" "" "" "" "" "" "" "87.7" "82.8" "109.4" "81.7" "69.6" "151.7" "82.7" "94.0" "124.9" "47.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6067622255201761803" "False" "Medium" "IsMasterProtein" "O95059" "Ribonuclease P protein subunit p14 OS=Homo sapiens OX=9606 GN=RPP14 PE=1 SV=3" "0.019" "False" "1.980" "6" "1" "1" "1" "124" "13.7" "7.75" "2.79" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01900" "11102" "ENSG00000163684" "RPP14" "O95059; Q53X97" "" "tRNA processing in the nucleus; Major pathway of rRNA processing in the nucleolus and cytosol" "2" "0" "1.085" "1.031" "0.939" "1.124" "1.051" "1.183" "0.972" "1.124" "0.918" "153.0" "166.1" "157.8" "143.7" "172.1" "160.8" "181.1" "148.8" "172.0" "140.5" "" "" "" "" "" "" "" "" "" "" "137.6" "134.4" "142.7" "140.3" "142.0" "160.8" "135.6" "131.4" "153.9" "50.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8359859415185382416" "False" "Medium" "IsMasterProtein" "O75575" "DNA-directed RNA polymerase III subunit RPC9 OS=Homo sapiens OX=9606 GN=CRCP PE=1 SV=1" "0.019" "False" "1.979" "5" "1" "1" "1" "148" "16.9" "5.39" "3.33" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf03874" "27297" "ENSG00000241258" "CRCP" "A8MUZ4; A8MW23; B2R4H4; B4E198; hsa:27297; O75575; Q3KRA3; Q5HYF1; Q8IXL4" "Myometrial relaxation and contraction pathways" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter; RNA Polymerase III Transcription Initiation From Type 3 Promoter; RNA Polymerase III Transcription Termination; Cytosolic sensors of pathogen-associated DNA ; RNA Polymerase III Chain Elongation" "8" "0" "0.829" "0.865" "0.799" "0.936" "0.956" "0.867" "0.871" "0.833" "1.060" "182.9" "151.6" "158.3" "146.1" "171.3" "174.8" "158.6" "159.3" "152.4" "193.9" "" "" "" "" "" "" "" "" "" "" "164.5" "122.7" "143.2" "142.6" "141.4" "174.8" "118.8" "140.7" "136.4" "69.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6635530035702083019" "False" "Medium" "IsMasterProtein" "Q68DK2" "Zinc finger FYVE domain-containing protein 26 OS=Homo sapiens OX=9606 GN=ZFYVE26 PE=1 SV=4" "0.019" "False" "1.972" "0" "1" "1" "1" "2539" "284.4" "6.39" "2.69" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf01363" "23503" "ENSG00000072121" "ZFYVE26" "B1B5Y3; B4E2U3; hsa:23503; O15035; Q68DK2; Q68DT9; Q6AW90; Q6ZR50; Q7Z3A4; Q7Z3I1; Q8N4W7; Q96H43" "" "" "0" "0" "0.982" "0.830" "0.811" "0.966" "1.345" "1.041" "0.959" "0.740" "1.253" "52.5" "51.5" "43.5" "42.5" "50.7" "70.5" "54.6" "50.3" "38.8" "65.7" "" "" "" "" "" "" "" "" "" "" "47.2" "41.7" "39.4" "41.5" "41.8" "70.5" "40.9" "44.4" "34.7" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6471377721056749589" "False" "Medium" "IsMasterProtein" "Cont_Q58D62" "Fetuin-B OS=Bos taurus OX=9913 GN=FETUB PE=1 SV=1" "0.019" "True" "1.971" "2" "1" "1" "1" "387" "42.6" "5.77" "2.79" "1" "other biological processes" "non-structural extracellular" "enzyme regulator activity" "Pf00031" "504615" "ENSBTAG00000017531" "FETUB" "bta:504615; Q58D62" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1385876623079047354" "False" "Medium" "IsMasterProtein" "Q9UFC0" "Leucine-rich repeat and WD repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=LRWD1 PE=1 SV=2" "0.020" "False" "1.960" "1" "1" "1" "1" "647" "70.8" "7.21" "2.90" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00400, Pf00560" "222229" "ENSG00000161036" "LRWD1" "A8K4K2; B2R9G2; hsa:222229; Q8N0T9; Q8WV43; Q96GJ2; Q9UFC0" "Male infertility" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6672818226938341619" "False" "Medium" "IsMasterProtein" "Q16816" "Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform OS=Homo sapiens OX=9606 GN=PHKG1 PE=1 SV=3" "0.021" "False" "1.941" "2" "1" "1" "1" "387" "45.0" "6.86" "2.21" "1" "other metabolic processes" "cytosol;other cell component" "kinase activity;other molecular function" "Pf00069" "5260" "ENSG00000164776" "PHKG1" "B7Z1D0; F5H2S1; hsa:5260; Q16816; Q75LP5" "Glycogen synthesis and degradation" "Glycogen breakdown (glycogenolysis)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1341245629562408069" "False" "Medium" "IsMasterProtein" "A6NFU8" "Pyroglutamyl-peptidase 1-like protein OS=Homo sapiens OX=9606 GN=PGPEP1L PE=2 SV=4" "0.022" "False" "1.938" "4" "1" "1" "1" "196" "21.6" "8.09" "3.37" "1" "protein metabolism" "" "other molecular function" "Pf01470" "145814" "ENSG00000183571" "PGPEP1L" "A6NFU8; H0YF86; hsa:145814" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-475333416762784380" "False" "Medium" "IsMasterProtein" "P43007" "Neutral amino acid transporter A OS=Homo sapiens OX=9606 GN=SLC1A4 PE=1 SV=1" "0.022" "False" "1.933" "1" "1" "1" "1" "532" "55.7" "6.25" "2.08" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "transporter activity" "Pf00375" "6509" "ENSG00000115902" "SLC1A4" "B7Z3C0; D6W5F0; P43007" "Neuroinflammation and glutamatergic signaling" "Amino acid transport across the plasma membrane" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "712228557573966988" "False" "Medium" "IsMasterProtein" "Q9ULC3" "Ras-related protein Rab-23 OS=Homo sapiens OX=9606 GN=RAB23 PE=1 SV=1" "0.022" "False" "1.933" "4" "1" "1" "1" "237" "26.6" "6.60" "1.87" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00071" "51715" "ENSG00000112210" "RAB23" "B2R9I5; hsa:51715; Q68DJ6; Q8NI06; Q9P023; Q9ULC3" "Genes related to primary cilium development (based on CRISPR); Ciliopathies; Bardet-Biedl syndrome" "RAB geranylgeranylation" "4" "0" "0.973" "1.000" "0.937" "1.032" "0.966" "1.029" "0.868" "0.878" "0.917" "124.5" "121.1" "124.5" "116.7" "128.5" "120.3" "128.1" "108.1" "109.3" "114.1" "" "" "" "" "" "" "" "" "" "" "111.9" "98.0" "112.6" "113.9" "106.1" "120.3" "95.9" "95.5" "97.8" "40.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7607180034342260294" "False" "Medium" "IsMasterProtein" "Q6P179" "Endoplasmic reticulum aminopeptidase 2 OS=Homo sapiens OX=9606 GN=ERAP2 PE=1 SV=2" "0.022" "False" "1.930" "1" "1" "1" "1" "960" "110.4" "6.71" "3.24" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "64167" "ENSG00000164308" "ERAP2" "hsa:64167; Q6P179; Q7Z5K1; Q8TD32; Q8WVJ4; Q9HBX2" "" "Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "1" "0" "0.818" "0.728" "0.843" "0.897" "0.679" "0.670" "0.708" "0.847" "0.741" "183.2" "149.8" "133.4" "154.5" "164.4" "124.4" "122.8" "129.7" "155.2" "135.7" "" "" "" "" "" "" "" "" "" "" "164.7" "121.2" "120.6" "150.8" "135.6" "124.4" "91.9" "114.6" "138.9" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7089722272324942505" "False" "Medium" "IsMasterProtein" "Q9NU23" "LYR motif-containing protein 2 OS=Homo sapiens OX=9606 GN=LYRM2 PE=1 SV=1" "0.022" "False" "1.926" "10" "1" "2" "1" "88" "10.4" "10.46" "4.48" "1" "cell organization and biogenesis" "mitochondrion" "" "Pf05347" "57226" "ENSG00000083099" "LYRM2" "B2R4U2; E1P517; hsa:57226; Q9NU23" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5441876211868438473" "False" "Medium" "IsMasterProtein" "Q92585" "Mastermind-like protein 1 OS=Homo sapiens OX=9606 GN=MAML1 PE=1 SV=3" "0.022" "False" "1.916" "1" "1" "1" "1" "1016" "108.0" "8.28" "3.08" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf09596, Pf20801, Pf20802" "9794" "ENSG00000161021; ENSG00000283780" "MAML1" "hsa:9794; Q92585; Q9NZ12" "Notch signaling; Canonical and non-canonical Notch signaling; Head and neck squamous cell carcinoma; Notch signaling pathway" "Formation of paraxial mesoderm; Constitutive Signaling by NOTCH1 PEST Domain Mutants; Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Pre-NOTCH Transcription and Translation; NOTCH1 Intracellular Domain Regulates Transcription; Notch-HLH transcription pathway; NOTCH3 Intracellular Domain Regulates Transcription; Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells; NOTCH2 intracellular domain regulates transcription; NOTCH4 Intracellular Domain Regulates Transcription; RUNX3 regulates NOTCH signaling" "15" "0" "0.942" "0.968" "0.991" "0.829" "0.997" "1.013" "0.956" "0.929" "1.062" "200.8" "189.2" "194.4" "199.0" "166.4" "200.2" "203.5" "192.0" "186.7" "213.2" "" "" "" "" "" "" "" "" "" "" "180.6" "153.1" "175.9" "194.3" "137.3" "200.2" "152.4" "169.6" "167.0" "76.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4139945587606400296" "False" "Medium" "IsMasterProtein" "Q07352" "mRNA decay activator protein ZFP36L1 OS=Homo sapiens OX=9606 GN=ZFP36L1 PE=1 SV=1" "0.022" "False" "1.915" "2" "1" "1" "1" "338" "36.3" "7.96" "2.09" "1" "cell adhesion;cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00642, Pf04553" "677" "ENSG00000185650" "ZFP36L1" "hsa:677; Q07352; Q13851" "Modulators of TCR signaling and T cell activation" "Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "96752444028096472" "False" "Medium" "IsMasterProtein" "Q8WWC4" "m-AAA protease-interacting protein 1, mitochondrial OS=Homo sapiens OX=9606 GN=MAIP1 PE=1 SV=1" "0.022" "False" "1.909" "2" "1" "1" "1" "291" "32.5" "9.17" "3.05" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "translation activity" "" "79568" "ENSG00000162972" "MAIP1" "hsa:79568; Q658V9; Q8WWC4; Q9H671" "" "Processing of SMDT1" "1" "0" "0.918" "0.931" "0.970" "0.862" "0.885" "0.963" "0.996" "1.114" "1.133" "199.9" "183.5" "186.1" "194.0" "172.4" "176.9" "192.5" "199.0" "222.7" "226.6" "" "" "" "" "" "" "" "" "" "" "179.7" "148.5" "168.4" "189.4" "142.2" "176.9" "144.2" "175.8" "199.3" "80.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-157533858987047858" "False" "Medium" "IsMasterProtein" "Q9HB14" "Potassium channel subfamily K member 13 OS=Homo sapiens OX=9606 GN=KCNK13 PE=1 SV=2" "0.022" "False" "1.907" "2" "1" "1" "1" "408" "45.4" "8.35" "2.12" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf07885" "56659" "ENSG00000152315" "KCNK13" "B5TJL8; hsa:56659; Q96E79; Q9HB14" "" "Phase 4 - resting membrane potential; Tandem pore domain halothane-inhibited K+ channel (THIK)" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2832980407509230771" "False" "Medium" "IsMasterProtein" "Q9UL41" "Paraneoplastic antigen Ma3 OS=Homo sapiens OX=9606 GN=PNMA3 PE=1 SV=3" "0.022" "False" "1.904" "3" "1" "1" "1" "463" "52.3" "9.50" "2.89" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf14893, Pf20846" "29944" "ENSG00000183837" "PNMA3" "D3DWT7; hsa:29944; Q9H0A4; Q9UL41" "" "" "0" "0" "1.014" "1.006" "0.982" "1.011" "0.873" "0.851" "1.070" "1.026" "0.752" "98.1" "99.4" "98.7" "96.3" "99.2" "85.6" "83.5" "105.0" "100.7" "73.8" "" "" "" "" "" "" "" "" "" "" "88.2" "80.5" "89.3" "94.0" "81.9" "85.6" "62.5" "92.7" "90.1" "26.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-352840310732152978" "False" "Medium" "IsMasterProtein" "Q8NFU3" "Thiosulfate:glutathione sulfurtransferase OS=Homo sapiens OX=9606 GN=TSTD1 PE=1 SV=3" "0.023" "False" "1.893" "6" "1" "3" "1" "115" "12.5" "6.07" "5.01" "1" "other metabolic processes;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;other molecular function" "Pf00581" "100131187" "ENSG00000215845" "TSTD1" "hsa:100131187; Q5SY48; Q5SY49; Q5SY50; Q5SY51; Q8NFU2; Q8NFU3; Q9BV22" "" "Sulfide oxidation to sulfate" "1" "0" "0.964" "0.962" "0.966" "1.060" "1.046" "1.049" "1.036" "1.091" "0.880" "405.8" "391.3" "390.2" "392.2" "430.4" "424.4" "425.8" "420.2" "442.6" "357.2" "" "" "" "" "" "" "" "" "" "" "364.9" "316.6" "353.0" "382.8" "355.1" "424.4" "318.8" "371.2" "396.1" "127.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3006395004919527007" "False" "Medium" "IsMasterProtein" "Q9BUP3" "Oxidoreductase HTATIP2 OS=Homo sapiens OX=9606 GN=HTATIP2 PE=1 SV=2" "0.023" "False" "1.889" "3" "1" "1" "1" "242" "27.0" "8.38" "2.46" "1" "protein metabolism;other metabolic processes;transport;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "kinase activity;other molecular function" "Pf13460" "10553" "ENSG00000109854" "HTATIP2" "A8K7S7; D3DQY8; hsa:10553; O15383; O60520; O95345; Q53GC1; Q53GG2; Q6IBI3; Q9BUP3" "" "" "0" "0" "1.066" "0.970" "1.027" "0.966" "0.951" "1.086" "1.013" "1.025" "0.807" "130.1" "138.7" "126.3" "133.7" "125.7" "123.8" "141.3" "131.8" "133.5" "105.0" "" "" "" "" "" "" "" "" "" "" "117.0" "112.3" "114.2" "130.5" "103.7" "123.8" "105.8" "116.4" "119.4" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4161818119007266512" "False" "Medium" "IsMasterProtein" "O43521" "Bcl-2-like protein 11 OS=Homo sapiens OX=9606 GN=BCL2L11 PE=1 SV=1" "0.023" "False" "1.889" "6" "1" "1" "1" "198" "22.2" "8.21" "2.08" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;mitochondrion;other cell component" "cytoskeletal activity;other molecular function" "Pf06773, Pf08945" "10018" "ENSG00000153094" "BCL2L11" "A8K2W2; hsa:10018; O43521; O43522; Q0MSE7; Q0MSE8; Q0MSE9; Q53R28; Q6JTU6; Q6T851; Q6TE14; Q6TE15; Q6TE16; Q6V402; Q8WYL6; Q8WYL7; Q8WYL8; Q8WYL9; Q8WYM0; Q8WYM1" "Apoptosis modulation and signaling; Brain-derived neurotrophic factor (BDNF) signaling pathway; Apoptosis; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced unfolded protein response; BMP2-WNT4-FOXO1 pathway in primary endometrial stromal cell differentiation; PI3K-Akt signaling pathway; Chromosomal and microsatellite instability in colorectal cancer ; Nonalcoholic fatty liver disease; EGFR tyrosine kinase inhibitor resistance; Host-pathogen interaction of human coronaviruses - apoptosis; Unfolded protein response; Galanin receptor pathway; 2q13 copy number variation syndrome; ErbB signaling pathway; DNA damage response (only ATM dependent)" "NRAGE signals death through JNK; Signaling by BRAF and RAF1 fusions; Activation of BIM and translocation to mitochondria ; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; RUNX3 regulates BCL2L11 (BIM) transcription; FLT3 Signaling; FOXO-mediated transcription of cell death genes" "24" "0" "1.072" "1.013" "0.850" "1.265" "1.089" "1.223" "0.657" "0.838" "0.530" "20.2" "21.7" "20.5" "17.2" "25.6" "22.0" "24.7" "13.3" "16.9" "10.7" "" "" "" "" "" "" "" "" "" "" "18.2" "17.5" "18.5" "16.8" "21.1" "22.0" "18.5" "11.7" "15.1" "3.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6218345119714256302" "False" "Medium" "IsMasterProtein" "Q7Z6M2" "F-box only protein 33 OS=Homo sapiens OX=9606 GN=FBXO33 PE=1 SV=1" "0.023" "False" "1.888" "1" "1" "1" "1" "555" "62.6" "7.36" "2.88" "1" "protein metabolism;other metabolic processes;other biological processes" "other cell component" "" "Pf12937" "254170" "ENSG00000165355" "FBXO33" "hsa:254170; Q6PIR2; Q7Z6M2; Q86TR2; Q86YE0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2438829351584223840" "False" "Medium" "IsMasterProtein" "O75529" "TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L OS=Homo sapiens OX=9606 GN=TAF5L PE=1 SV=1" "0.023" "False" "1.884" "2" "1" "1" "1" "589" "66.1" "5.88" "3.10" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00400, Pf04494" "27097" "ENSG00000135801" "TAF5L" "hsa:27097; O75529; Q5TDI5; Q5TDI6; Q8IW31" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5621842442587442909" "False" "Medium" "IsMasterProtein" "Q6ZNA5" "Ferric-chelate reductase 1 OS=Homo sapiens OX=9606 GN=FRRS1 PE=1 SV=2" "0.023" "False" "1.883" "1" "1" "1" "1" "592" "66.1" "7.47" "2.78" "1" "other biological processes" "other membranes" "other molecular function" "Pf02014, Pf03351" "391059" "ENSG00000156869" "FRRS1" "A6NLN7; hsa:391059; Q6ZNA5" "" "" "0" "0" "1.106" "1.093" "1.174" "1.210" "1.136" "1.126" "1.208" "1.284" "0.870" "93.7" "103.6" "102.4" "110.1" "113.4" "106.4" "105.5" "113.2" "120.4" "81.5" "" "" "" "" "" "" "" "" "" "" "84.3" "83.8" "92.6" "107.4" "93.6" "106.4" "79.0" "100.0" "107.7" "29.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1089624878569617395" "False" "Medium" "IsMasterProtein" "Q9NW61" "Pleckstrin homology domain-containing family J member 1 OS=Homo sapiens OX=9606 GN=PLEKHJ1 PE=1 SV=1" "0.023" "False" "1.880" "10" "1" "3" "1" "149" "17.5" "7.84" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport" "cytosol;ER/Golgi;other cytoplasmic organelle" "" "Pf00169" "55111" "ENSG00000104886" "PLEKHJ1" "B3KUQ9; D6W604; hsa:55111; Q9NW61" "" "" "0" "0" "0.917" "0.869" "0.945" "0.920" "0.875" "0.905" "0.847" "0.819" "1.093" "268.8" "246.5" "233.5" "254.0" "247.3" "235.2" "243.4" "227.6" "220.2" "293.9" "" "" "" "" "" "" "" "" "" "" "241.6" "199.5" "211.2" "247.9" "204.0" "235.2" "182.2" "201.0" "197.0" "104.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8125851440420054284" "False" "Medium" "IsMasterProtein" "Q86UT8" "Centrosomal AT-AC splicing factor OS=Homo sapiens OX=9606 GN=CENATAC PE=1 SV=1" "0.023" "False" "1.880" "3" "1" "1" "1" "332" "38.0" "8.22" "0.00" "1" "cell cycle OR cell proliferation;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytoskeleton;other cell component" "" "Pf14968" "338657" "ENSG00000186166; ENSG00000280975" "CENATAC" "hsa:338657; Q86UT8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3290991412812475155" "False" "Medium" "IsMasterProtein" "Q5T9A4" "ATPase family AAA domain-containing protein 3B OS=Homo sapiens OX=9606 GN=ATAD3B PE=1 SV=1" "0.023" "False" "1.869" "1" "1" "1" "1" "648" "72.5" "9.20" "2.03" "1" "cell organization and biogenesis" "plasma membrane;other membranes;mitochondrion" "other molecular function" "Pf00004, Pf12037" "83858" "ENSG00000160072" "ATAD3B" "A8K3H1; hsa:83858; Q5T9A4; Q6ZRB5; Q9BUK4; Q9ULE7" "1p36 copy number variation syndrome" "Neutrophil degranulation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5201003566343787009" "False" "Medium" "IsMasterProtein" "P62273" "Small ribosomal subunit protein uS14 OS=Homo sapiens OX=9606 GN=RPS29 PE=1 SV=2" "0.023" "False" "1.869" "13" "1" "1" "1" "56" "6.7" "10.13" "2.62" "1" "protein metabolism;other metabolic processes" "other membranes;cytosol;ER/Golgi;translational apparatus;nucleus;other cell component" "other molecular function" "Pf00253" "6235" "ENSG00000213741" "RPS29" "A8MZ73; hsa:6235; P30054; P62273" "Cytoplasmic ribosomal proteins" "Regulation of expression of SLITs and ROBOs; L13a-mediated translational silencing of Ceruloplasmin expression; Translation initiation complex formation; Formation of a pool of free 40S subunits; Formation of the ternary complex, and subsequently, the 43S complex; Ribosomal scanning and start codon recognition; GTP hydrolysis and joining of the 60S ribosomal subunit; Major pathway of rRNA processing in the nucleolus and cytosol; SARS-CoV-2 modulates host translation machinery; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); SRP-dependent cotranslational protein targeting to membrane; Viral mRNA Translation; Response of EIF2AK4 (GCN2) to amino acid deficiency; Peptide chain elongation; Selenocysteine synthesis; Eukaryotic Translation Termination; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); SARS-CoV-1 modulates host translation machinery" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1074921125949548945" "False" "Medium" "IsMasterProtein" "Q6V0I7" "Protocadherin Fat 4 OS=Homo sapiens OX=9606 GN=FAT4 PE=1 SV=2" "0.023" "False" "1.868" "0" "1" "1" "1" "4981" "542.4" "4.94" "2.48" "1" "cell adhesion;developmental processes;signal transduction" "plasma membrane;other membranes" "other molecular function" "Pf00008, Pf00028, Pf02210, Pf07645, Pf12661" "79633" "ENSG00000196159" "FAT4" "A8K5Z6; B5MDG4; hsa:79633; Q3LIA6; Q6V0I7; Q8TCK7; Q9H5T6" "GDNF/RET signaling axis; Development of ureteric collection system; GDNF signaling; Markers of kidney cell lineage" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4738294880547824619" "False" "Medium" "IsMasterProtein" "Q9BQ15" "SOSS complex subunit B1 OS=Homo sapiens OX=9606 GN=NABP2 PE=1 SV=1" "0.023" "False" "1.868" "3" "1" "1" "1" "211" "22.3" "9.06" "2.40" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf21473" "79035" "ENSG00000139579" "NABP2" "A6NDF8; hsa:79035; Q6XYC8; Q9BQ15" "Mesodermal commitment pathway" "RNA polymerase II transcribes snRNA genes" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5683833543750550495" "False" "Medium" "IsMasterProtein" "Q15835" "Rhodopsin kinase GRK1 OS=Homo sapiens OX=9606 GN=GRK1 PE=1 SV=1" "0.023" "False" "1.866" "2" "1" "1" "1" "563" "63.5" "5.87" "2.25" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "other membranes;other cell component" "kinase activity;other molecular function" "Pf00069, Pf00615" "6011" "ENSG00000185974; ENSG00000288263" "GRK1" "hsa:6011; Q15835; Q53X14" "Chemokine signaling pathway" "Inactivation, recovery and regulation of the phototransduction cascade" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6721724367357589607" "False" "Medium" "IsMasterProtein" "Q6IPU0" "Centromere protein P OS=Homo sapiens OX=9606 GN=CENPP PE=1 SV=1" "0.023" "False" "1.865" "3" "1" "2" "1" "288" "33.1" "6.27" "1.95" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf13096" "401541" "ENSG00000188312; ENSG00000291348" "CENPP" "B3KRA5; B3KS17; hsa:401541; Q5T9F8; Q5T9F9; Q6IPU0" "" "Deposition of new CENPA-containing nucleosomes at the centromere; Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7711116662832737595" "False" "Medium" "IsMasterProtein" "Q53EZ4" "Centrosomal protein of 55 kDa OS=Homo sapiens OX=9606 GN=CEP55 PE=1 SV=3" "0.023" "False" "1.859" "2" "1" "2" "1" "464" "54.1" "7.01" "5.23" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf12180" "55165" "ENSG00000138180" "CEP55" "B2RDG8; D3DR37; hsa:55165; Q32WF5; Q3MV20; Q53EZ4; Q5VY28; Q6N034; Q96H32; Q9NVS7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2182760318696824759" "False" "Medium" "IsMasterProtein" "Q8IWP9" "Coiled-coil domain-containing protein 28A OS=Homo sapiens OX=9606 GN=CCDC28A PE=1 SV=1" "0.024" "False" "1.856" "3" "1" "1" "1" "274" "30.3" "9.25" "1.98" "1" "" "" "" "Pf13270" "25901" "" "CCDC28A" "E1P591; Q32NC7; Q66K67; Q8IWP9; Q96E23; Q9Y430" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4691271095298353856" "False" "Medium" "IsMasterProtein" "Q13114" "TNF receptor-associated factor 3 OS=Homo sapiens OX=9606 GN=TRAF3 PE=1 SV=2" "0.024" "False" "1.852" "1" "1" "1" "1" "568" "64.4" "7.91" "2.34" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;mitochondrion;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf02176, Pf21355, Pf21363" "7187" "ENSG00000131323" "TRAF3" "B7Z8C4; hsa:7187; Q12990; Q13076; Q13114; Q13947; Q6AZX1; Q9UNL1" "RANKL/RANK signaling pathway; TNF-related weak inducer of apoptosis (TWEAK) signaling pathway; IL-17 signaling pathway; Apoptosis; TLR4 signaling and tolerance; Toll-like receptor signaling related to MyD88; Novel intracellular components of RIG-I-like receptor pathway; Oxidative damage response; miRNA role in immune response in sepsis; Measles virus infection; Small cell lung cancer; Hepatitis B infection; Head and neck squamous cell carcinoma; Type I interferon induction and signaling during SARS-CoV-2 infection; Activation of NLRP3 inflammasome by SARS-CoV-2; Host-pathogen interaction of human coronaviruses - interferon induction; SARS coronavirus and innate immunity; Mitochondrial immune response to SARS-CoV-2; SARS-CoV-2 innate immunity evasion and cell-specific immune response; Network map of SARS-CoV-2 signaling pathway; SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation; SARS-CoV-2 mitochondrial chronic oxidative stress and endothelial dysfunction; 2q37 copy number variation syndrome; 13q12.12 copy number variation; Toll-like receptor signaling pathway" "Ovarian tumor domain proteases; SARS-CoV-2 activates/modulates innate and adaptive immune responses; SARS-CoV-1 activates/modulates innate immune responses; Activation of IRF3, IRF7 mediated by TBK1, IKBKE; Negative regulators of DDX58/IFIH1 signaling; TICAM1-dependent activation of IRF3/IRF7; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway; TRAF3 deficiency - HSE; TRAF3-dependent IRF activation pathway" "35" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-446903145353844215" "False" "Medium" "IsMasterProtein" "Q96GF1" "E3 ubiquitin-protein ligase RNF185 OS=Homo sapiens OX=9606 GN=RNF185 PE=1 SV=1" "0.024" "False" "1.850" "8" "1" "1" "1" "192" "20.4" "6.52" "2.84" "1" "protein metabolism;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion;ER/Golgi" "other molecular function" "Pf00097" "91445" "ENSG00000138942" "RNF185" "A8K5C1; A9X3T8; hsa:91445; Q8N900; Q96GF1" "" "ABC-family proteins mediated transport; Defective CFTR causes cystic fibrosis; ER Quality Control Compartment (ERQC)" "3" "0" "0.738" "0.570" "0.841" "1.036" "0.866" "0.777" "0.937" "1.073" "0.933" "17.5" "12.9" "10.0" "14.7" "18.2" "15.2" "13.6" "16.4" "18.8" "16.3" "" "" "" "" "" "" "" "" "" "" "15.7" "10.5" "9.0" "14.4" "15.0" "15.2" "10.2" "14.5" "16.8" "5.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-818357579634992353" "False" "Medium" "IsMasterProtein" "Q13671" "Ras and Rab interactor 1 OS=Homo sapiens OX=9606 GN=RIN1 PE=1 SV=4" "0.024" "False" "1.850" "1" "1" "1" "1" "783" "84.0" "8.02" "2.52" "1" "transport;signal transduction" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "enzyme regulator activity;other molecular function" "Pf00788, Pf02204" "9610" "ENSG00000174791" "RIN1" "hsa:9610; O15010; Q00427; Q13671; Q96CC8" "Ras signaling; EGF/EGFR signaling pathway" "RAB GEFs exchange GTP for GDP on RABs" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7372270157556581361" "False" "Medium" "IsMasterProtein" "Q8IY21" "Probable ATP-dependent RNA helicase DDX60 OS=Homo sapiens OX=9606 GN=DDX60 PE=1 SV=3" "0.024" "False" "1.846" "1" "1" "1" "1" "1712" "197.7" "7.59" "0.00" "1" "stress response;other biological processes" "cytosol;cytoskeleton;other cell component" "nucleic acid binding activity;other molecular function" "Pf00270, Pf00271" "55601" "ENSG00000137628" "DDX60" "hsa:55601; Q6PK35; Q8IY21; Q9NVE3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5196394549713774835" "False" "Medium" "IsMasterProtein" "Q69YU5" "Ubiquinol-cytochrome c reductase complex assembly factor 6 OS=Homo sapiens OX=9606 GN=UQCC6 PE=1 SV=2" "0.024" "False" "1.844" "10" "1" "1" "1" "71" "8.0" "9.16" "2.94" "1" "cell organization and biogenesis" "other membranes;mitochondrion" "" "Pf14990" "728568" "ENSG00000204954" "UQCC6" "hsa:728568; Q69YU5" "" "" "0" "0" "0.838" "0.946" "0.886" "0.819" "0.866" "0.933" "0.921" "0.831" "0.446" "275.4" "230.9" "260.5" "244.0" "225.5" "238.6" "256.9" "253.6" "228.8" "122.8" "" "" "" "" "" "" "" "" "" "" "247.6" "186.8" "235.7" "238.2" "186.1" "238.6" "192.3" "224.0" "204.7" "43.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "700962882468827525" "False" "Medium" "IsMasterProtein" "Q9ULI2" "Beta-citrylglutamate synthase B OS=Homo sapiens OX=9606 GN=RIMKLB PE=1 SV=2" "0.024" "False" "1.842" "2" "1" "1" "1" "386" "42.4" "6.00" "2.40" "1" "protein metabolism;other metabolic processes" "cytosol;other cell component" "other molecular function" "Pf08443" "57494" "ENSG00000166532" "RIMKLB" "B7Z834; D3DUV2; hsa:57494; Q8N4P4; Q8WTW6; Q9ULI2" "" "Glutamate and glutamine metabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-279239733910497261" "False" "Medium" "IsMasterProtein" "Q8NAV1" "Pre-mRNA-splicing factor 38A OS=Homo sapiens OX=9606 GN=PRPF38A PE=1 SV=1" "0.024" "False" "1.834" "3" "1" "1" "1" "312" "37.5" "9.96" "2.05" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "" "Pf03371, Pf12871" "84950" "ENSG00000134748" "PRPF38A" "hsa:84950; Q8NAV1; Q96JW1; Q9BVZ8" "MECP2 and associated Rett syndrome" "mRNA Splicing - Major Pathway" "2" "0" "1.016" "1.068" "0.968" "0.992" "1.102" "1.090" "1.032" "1.038" "0.867" "187.2" "190.1" "200.0" "181.3" "185.8" "206.3" "204.0" "193.2" "194.3" "162.3" "" "" "" "" "" "" "" "" "" "" "168.3" "153.9" "180.9" "176.9" "153.3" "206.3" "152.7" "170.6" "173.9" "57.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "155872051890046023" "False" "Medium" "IsMasterProtein" "P31269" "Homeobox protein Hox-A9 OS=Homo sapiens OX=9606 GN=HOXA9 PE=1 SV=4" "0.024" "False" "1.834" "3" "1" "1" "1" "272" "30.2" "8.62" "2.81" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf04617" "3205" "ENSG00000078399" "HOXA9" "hsa:3205; O43369; O43429; P31269; Q99820" "NF1 copy number variation syndrome" "" "1" "0" "1.116" "0.963" "0.707" "1.058" "0.818" "1.058" "0.880" "0.969" "0.875" "155.1" "173.1" "149.4" "109.7" "164.0" "126.9" "164.1" "136.5" "150.3" "135.6" "" "" "" "" "" "" "" "" "" "" "139.4" "140.1" "135.1" "107.1" "135.3" "126.9" "122.9" "120.5" "134.5" "48.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7431042407162154153" "False" "Medium" "IsMasterProtein" "Q6UW68" "Transmembrane protein 205 OS=Homo sapiens OX=9606 GN=TMEM205 PE=1 SV=1" "0.025" "False" "1.831" "9" "1" "1" "1" "189" "21.2" "8.62" "2.38" "1" "" "other membranes" "" "Pf13664" "374882" "ENSG00000105518" "TMEM205" "hsa:374882; Q6UW68" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1877789849069093785" "False" "Medium" "IsMasterProtein" "Q9UIW2" "Plexin-A1 OS=Homo sapiens OX=9606 GN=PLXNA1 PE=1 SV=3" "0.025" "False" "1.824" "0" "1" "1" "1" "1896" "210.9" "6.92" "2.15" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf01403, Pf01437, Pf01833, Pf08337, Pf17960, Pf18020, Pf20170" "5361" "ENSG00000114554" "PLXNA1" "hsa:5361; Q9UIW2" "" "RHOD GTPase cycle; RND1 GTPase cycle; CRMPs in Sema3A signaling; Sema3A PAK dependent Axon repulsion; SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion; Other semaphorin interactions" "6" "0" "1.033" "1.111" "1.044" "0.941" "0.852" "1.212" "1.135" "0.857" "0.787" "56.7" "58.6" "63.0" "59.2" "53.4" "48.4" "68.8" "64.4" "48.6" "44.6" "" "" "" "" "" "" "" "" "" "" "51.0" "47.4" "57.0" "57.8" "44.0" "48.4" "51.5" "56.9" "43.5" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2746729675254705765" "False" "Medium" "IsMasterProtein" "Q6ZN18" "Zinc finger protein AEBP2 OS=Homo sapiens OX=9606 GN=AEBP2 PE=1 SV=2" "0.025" "False" "1.822" "1" "1" "1" "1" "517" "54.4" "5.21" "2.61" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "121536" "ENSG00000139154" "AEBP2" "hsa:121536; Q59FS5; Q6ZN18; Q6ZN62; Q96BG3" "Histone modifications; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2)" "PKMTs methylate histone lysines; PRC2 methylates histones and DNA" "5" "0" "0.973" "0.936" "1.043" "0.983" "0.890" "1.009" "0.908" "0.935" "1.550" "296.6" "288.5" "277.5" "309.2" "291.6" "264.1" "299.1" "269.2" "277.4" "459.8" "" "" "" "" "" "" "" "" "" "" "266.7" "233.5" "251.0" "301.8" "240.6" "264.1" "224.0" "237.8" "248.2" "164.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3888271252204207662" "False" "Medium" "IsMasterProtein" "Q9UM73" "ALK tyrosine kinase receptor OS=Homo sapiens OX=9606 GN=ALK PE=1 SV=3" "0.025" "False" "1.820" "1" "1" "1" "1" "1620" "176.3" "7.08" "2.90" "1" "protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00629, Pf07714, Pf12810" "238" "ENSG00000171094" "ALK" "A6P4T4; A6P4V4; hsa:238; Q4ZFX9; Q53QQ6; Q53RZ4; Q59FI3; Q9UM73; Q9Y4K6" "Pluripotent stem cell differentiation pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer" "Signaling by ALK fusions and activated point mutants; ALK mutants bind TKIs; Signaling by ALK; MDK and PTN in ALK signaling; ASP-3026-resistant ALK mutants; NVP-TAE684-resistant ALK mutants; alectinib-resistant ALK mutants; brigatinib-resistant ALK mutants; ceritinib-resistant ALK mutants; crizotinib-resistant ALK mutants; lorlatinib-resistant ALK mutants" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1998394200407490675" "False" "Medium" "IsMasterProtein" "Q8WUA4" "General transcription factor 3C polypeptide 2 OS=Homo sapiens OX=9606 GN=GTF3C2 PE=1 SV=2" "0.025" "False" "1.818" "2" "1" "1" "1" "911" "100.6" "7.31" "2.51" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00400" "2976" "ENSG00000115207" "GTF3C2" "D6W557; hsa:2976; Q16632; Q8WUA4; Q9BWI7" "" "RNA Polymerase III Abortive And Retractive Initiation; RNA Polymerase III Transcription Initiation From Type 1 Promoter; RNA Polymerase III Transcription Initiation From Type 2 Promoter" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1822913707672992283" "False" "Medium" "IsMasterProtein" "Q9NPH0" "Lysophosphatidic acid phosphatase type 6 OS=Homo sapiens OX=9606 GN=ACP6 PE=1 SV=3" "0.025" "False" "1.817" "2" "1" "1" "1" "428" "48.9" "6.47" "2.44" "1" "other metabolic processes;other biological processes" "mitochondrion;other cell component" "other molecular function" "Pf00328" "51205" "ENSG00000162836" "ACP6" "hsa:51205; Q59G61; Q5T490; Q6IAQ3; Q7LG81; Q9NPH0; Q9UIG6; X5D289" "1q21.1 copy number variation syndrome" "Synthesis of PA" "2" "0" "1.028" "0.969" "0.871" "1.079" "0.977" "1.048" "1.150" "0.918" "0.755" "84.8" "87.2" "82.2" "73.8" "91.5" "82.8" "88.8" "97.5" "77.9" "64.0" "" "" "" "" "" "" "" "" "" "" "76.2" "70.5" "74.4" "72.1" "75.5" "82.8" "66.5" "86.1" "69.7" "22.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1276510968387632790" "False" "Medium" "IsMasterProtein" "P22794" "Protein EVI2A OS=Homo sapiens OX=9606 GN=EVI2A PE=1 SV=2" "0.025" "False" "1.815" "3" "1" "1" "1" "236" "26.2" "8.56" "3.78" "1" "" "other membranes" "other molecular function" "Pf05399" "2123" "ENSG00000126860" "EVI2A" "B2R5X2; B4DHX8; hsa:2123; P22794" "NF1 copy number variation syndrome" "" "1" "0" "1.048" "0.881" "1.048" "1.005" "0.998" "1.159" "1.119" "0.916" "0.982" "178.9" "187.4" "157.6" "187.4" "179.7" "178.6" "207.3" "200.2" "163.9" "175.6" "" "" "" "" "" "" "" "" "" "" "160.8" "151.6" "142.5" "182.9" "148.3" "178.6" "155.2" "176.8" "146.7" "62.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3978258356038081382" "False" "Medium" "IsMasterProtein" "Q13416" "Origin recognition complex subunit 2 OS=Homo sapiens OX=9606 GN=ORC2 PE=1 SV=2" "0.026" "False" "1.806" "1" "1" "1" "1" "577" "65.9" "6.51" "2.34" "1" "DNA metabolism;other metabolic processes;other biological processes" "cytoskeleton;nucleus;other cell component" "nucleic acid binding activity" "Pf04084" "4999" "ENSG00000115942" "ORC2" "hsa:4999; Q13204; Q13416; Q53TX5" "Cell cycle; G1 to S cell cycle control; DNA replication" "Orc1 removal from chromatin; Activation of ATR in response to replication stress; Activation of the pre-replicative complex; E2F-enabled inhibition of pre-replication complex formation; Assembly of the ORC complex at the origin of replication; CDC6 association with the ORC:origin complex" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4261642457935236614" "False" "Medium" "IsMasterProtein" "Q9NS73" "MAP3K12-binding inhibitory protein 1 OS=Homo sapiens OX=9606 GN=MBIP PE=1 SV=2" "0.026" "False" "1.803" "3" "1" "1" "1" "344" "39.3" "7.24" "1.73" "1" "other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "51562" "ENSG00000151332" "MBIP" "hsa:51562; Q86TZ2; Q96AS5; Q9BS93; Q9NS73; Q9NZE1" "" "Formation of WDR5-containing histone-modifying complexes; HATs acetylate histones" "2" "0" "1.047" "1.182" "0.971" "0.945" "0.930" "0.720" "0.947" "0.917" "0.941" "61.8" "64.7" "73.0" "60.0" "58.4" "57.5" "44.5" "58.5" "56.7" "58.2" "" "" "" "" "" "" "" "" "" "" "55.6" "52.4" "66.1" "58.6" "48.2" "57.5" "33.3" "51.7" "50.7" "20.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4439921504138338732" "False" "Medium" "IsMasterProtein" "Q6P4E1" "Protein GOLM2 OS=Homo sapiens OX=9606 GN=GOLM2 PE=1 SV=2" "0.026" "False" "1.802" "2" "1" "1" "1" "436" "49.5" "5.29" "0.00" "1" "" "other membranes;ER/Golgi" "" "" "113201" "ENSG00000166734" "GOLM2" "B4DPZ6; G5E934; Q6P4E1; Q6UY45; Q96EM1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6544451976657015387" "False" "Medium" "IsMasterProtein" "Q8TC44" "POC1 centriolar protein homolog B OS=Homo sapiens OX=9606 GN=POC1B PE=1 SV=1" "0.026" "False" "1.797" "2" "1" "1" "1" "478" "53.6" "7.24" "2.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf00400" "282809" "ENSG00000139323" "POC1B" "G3V1X0; hsa:282809; Q8TC44" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2644612551078172980" "False" "Medium" "IsMasterProtein" "Q9NYQ3" "2-Hydroxyacid oxidase 2 OS=Homo sapiens OX=9606 GN=HAO2 PE=1 SV=1" "0.026" "False" "1.795" "2" "1" "1" "1" "351" "38.8" "7.64" "2.52" "1" "other metabolic processes" "cytosol;other cytoplasmic organelle" "other molecular function" "Pf01070" "51179" "ENSG00000116882" "HAO2" "hsa:51179; Q2TU86; Q5QP00; Q9NYQ3; Q9UJS6" "" "Peroxisomal lipid metabolism; Peroxisomal protein import" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5230148054897326817" "False" "Medium" "IsMasterProtein" "Q3SYG4" "Protein PTHB1 OS=Homo sapiens OX=9606 GN=BBS9 PE=1 SV=1" "0.026" "False" "1.793" "2" "1" "1" "1" "887" "99.2" "5.55" "1.61" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cell component" "" "Pf14727, Pf14728" "27241" "ENSG00000122507" "BBS9" "E9PDC9; hsa:27241; P78514; Q3SYG4; Q7KYS6; Q7KYS7; Q8N570; Q99844; Q99854; Q9Y699; Q9Y6A0" "Ciliary landscape; Genes related to primary cilium development (based on CRISPR); Joubert syndrome; Ciliopathies; Bardet-Biedl syndrome" "BBSome-mediated cargo-targeting to cilium" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6753612523843218234" "False" "Medium" "IsMasterProtein" "Q5T7W7" "Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2 OS=Homo sapiens OX=9606 GN=TSTD2 PE=1 SV=1" "0.026" "False" "1.792" "3" "1" "1" "1" "516" "58.2" "7.20" "2.56" "1" "" "" "" "Pf00581, Pf12368, Pf17773" "158427" "ENSG00000136925" "TSTD2" "A6NMJ4; A8K584; hsa:158427; Q5T7W7; Q6ZQZ6; Q8IYM3; Q8WY73; Q96ML6; Q96MU1" "" "" "0" "0" "0.893" "0.891" "1.206" "0.721" "0.940" "1.142" "1.177" "0.926" "0.752" "71.9" "64.2" "64.0" "86.7" "51.8" "67.6" "82.1" "84.6" "66.6" "54.1" "" "" "" "" "" "" "" "" "" "" "64.6" "51.9" "57.9" "84.6" "42.8" "67.6" "61.5" "74.7" "59.6" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5110647921577969291" "False" "Medium" "IsMasterProtein" "O95139" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 OS=Homo sapiens OX=9606 GN=NDUFB6 PE=1 SV=3" "0.026" "False" "1.790" "5" "1" "1" "1" "128" "15.5" "9.63" "2.49" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf09782" "4712" "ENSG00000165264" "NDUFB6" "A8K0Y7; hsa:4712; O95139; Q5VYT2; Q6IB84" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis; Mitochondrial protein degradation" "6" "0" "0.916" "1.059" "1.016" "1.000" "1.100" "0.970" "0.957" "0.994" "0.883" "126.9" "116.3" "134.4" "128.9" "126.9" "139.6" "123.1" "121.5" "126.1" "112.1" "" "" "" "" "" "" "" "" "" "" "114.1" "94.1" "121.6" "125.8" "104.7" "139.6" "92.2" "107.3" "112.9" "40.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-419593273491942870" "False" "Medium" "IsMasterProtein" "P0C7P3" "Protein SLFN14 OS=Homo sapiens OX=9606 GN=SLFN14 PE=1 SV=2" "0.027" "False" "1.785" "1" "1" "2" "1" "912" "103.8" "8.24" "4.65" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "translation activity;other molecular function" "Pf04326, Pf17057, Pf21026" "342618" "ENSG00000236320" "SLFN14" "B2RTW9; hsa:342618; P0C7P3" "17q12 copy number variation syndrome" "" "1" "0" "1.010" "0.957" "1.052" "1.289" "0.998" "1.255" "1.219" "0.919" "0.921" "95.5" "96.4" "91.4" "100.4" "123.1" "95.3" "119.9" "116.4" "87.8" "88.0" "" "" "" "" "" "" "" "" "" "" "85.9" "78.0" "82.7" "98.0" "101.6" "95.3" "89.7" "102.8" "78.6" "31.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8932442101095546032" "False" "Medium" "IsMasterProtein" "Q5H8A4" "GPI ethanolamine phosphate transferase 2 OS=Homo sapiens OX=9606 GN=PIGG PE=1 SV=1" "0.027" "False" "1.782" "1" "1" "2" "1" "983" "108.1" "7.15" "5.38" "1" "protein metabolism;other metabolic processes" "other membranes;ER/Golgi" "other molecular function" "Pf01663, Pf19316" "54872" "ENSG00000174227" "PIGG" "B4DKC7; hsa:54872; Q2TAK5; Q5H8A4; Q6UX31; Q7L5Y4; Q8N866; Q8NCC9; Q96SY9; Q9BVT7; Q9NXG5" "" "Synthesis of glycosylphosphatidylinositol (GPI)" "1" "0" "0.947" "0.955" "0.915" "0.937" "0.935" "0.951" "0.906" "0.955" "1.150" "393.4" "372.6" "375.8" "359.9" "368.5" "368.0" "374.2" "356.5" "375.8" "452.4" "" "" "" "" "" "" "" "" "" "" "353.7" "301.5" "339.9" "351.3" "304.1" "368.0" "280.2" "314.9" "336.2" "161.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4757838979120085140" "False" "Medium" "IsMasterProtein" "P17405" "Sphingomyelin phosphodiesterase OS=Homo sapiens OX=9606 GN=SMPD1 PE=1 SV=5" "0.027" "False" "1.779" "2" "1" "1" "1" "631" "69.9" "7.28" "0.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00149, Pf19272" "6609" "ENSG00000166311" "SMPD1" "A8K8M3; E9PKS3; hsa:6609; P17405; P17406; Q13811; Q16837; Q16841" "Ovarian infertility; Sphingolipid metabolism: integrated pathway" "Glycosphingolipid catabolism" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "Not Found" "High" "High" "High" "1" "" "8231836584422235478" "False" "Medium" "IsMasterProtein" "O15533" "Tapasin OS=Homo sapiens OX=9606 GN=TAPBP PE=1 SV=2" "0.027" "False" "1.779" "2" "1" "1" "1" "448" "47.5" "6.99" "0.00" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "other membranes;ER/Golgi" "signal transduction activity or receptor binding;other molecular function" "Pf07654" "6892" "ENSG00000112493; ENSG00000206208; ENSG00000206281; ENSG00000231925; ENSG00000236490" "TAPBP" "A2AB91; A2ABC0; B0V003; B0V0A6; B2ZUA4; E9PGM2; hsa:6892; O15210; O15272; O15533; Q5STJ8; Q5STK6; Q5STQ5; Q5STQ6; Q66K65; Q96KK7; Q9HAN8; Q9UEE0; Q9UEE4; Q9UIZ6; Q9Y6K2" "" "ER-Phagosome pathway; Antigen Presentation: Folding, assembly and peptide loading of class I MHC" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9033266282732166818" "False" "Medium" "IsMasterProtein" "Q9Y663" "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 OS=Homo sapiens OX=9606 GN=HS3ST3A1 PE=1 SV=1" "0.027" "False" "1.779" "2" "1" "1" "1" "406" "44.9" "9.50" "2.59" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00685" "9955" "ENSG00000153976" "HS3ST3A1" "A8K7N2; hsa:9955; Q9Y663" "Glycosaminoglycan synthesis in fibroblasts; Metapathway biotransformation Phase I and II" "HS-GAG biosynthesis" "3" "0" "1.033" "0.911" "0.858" "1.093" "0.768" "0.869" "0.850" "0.892" "1.044" "133.4" "137.9" "121.5" "114.5" "145.8" "102.4" "115.9" "113.4" "119.1" "139.3" "" "" "" "" "" "" "" "" "" "" "120.0" "111.6" "109.9" "111.8" "120.3" "102.4" "86.8" "100.1" "106.6" "49.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "277201570289442109" "False" "Medium" "IsMasterProtein" "O75147" "Obscurin-like protein 1 OS=Homo sapiens OX=9606 GN=OBSL1 PE=1 SV=4" "0.027" "False" "1.775" "0" "1" "1" "1" "1896" "206.8" "5.63" "2.29" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf07679, Pf13927" "23363" "ENSG00000124006" "OBSL1" "A0A024R468; A4KVA4; A4KVA5; hsa:23363; O75147; Q96IW3; S4R3M6" "" "Neddylation" "1" "0" "0.893" "0.910" "0.605" "0.833" "0.679" "0.775" "0.779" "0.688" "0.554" "128.9" "115.1" "117.3" "77.9" "107.3" "87.6" "99.9" "100.4" "88.7" "71.4" "" "" "" "" "" "" "" "" "" "" "115.9" "93.1" "106.1" "76.1" "88.5" "87.6" "74.8" "88.7" "79.4" "25.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1879348305220044613" "False" "Medium" "IsMasterProtein" "P22732" "Solute carrier family 2, facilitated glucose transporter member 5 OS=Homo sapiens OX=9606 GN=SLC2A5 PE=1 SV=1" "0.027" "False" "1.775" "1" "1" "1" "1" "501" "54.9" "6.04" "2.65" "1" "other metabolic processes;transport;other biological processes" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00083" "6518" "ENSG00000142583" "SLC2A5" "hsa:6518; P22732; Q14770; Q5T977; Q8IVB3" "Nuclear receptors meta-pathway; NRF2 pathway; Glycolysis and gluconeogenesis; Metabolic Epileptic Disorders" "Neutrophil degranulation; Intestinal hexose absorption" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8539221583394441317" "False" "Medium" "IsMasterProtein" "O95251" "Histone acetyltransferase KAT7 OS=Homo sapiens OX=9606 GN=KAT7 PE=1 SV=1" "0.027" "False" "1.773" "2" "1" "1" "1" "611" "70.6" "8.85" "2.52" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01530, Pf01853, Pf17772" "11143" "ENSG00000136504" "KAT7" "B3KN74; B4DF85; B4DFB4; B4DFE0; B4DGY4; E7ER15; G5E9K7; hsa:11143; O95251" "Androgen receptor signaling pathway" "HATs acetylate histones" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8651420309952224614" "False" "Medium" "IsMasterProtein" "O15105" "Mothers against decapentaplegic homolog 7 OS=Homo sapiens OX=9606 GN=SMAD7 PE=1 SV=1" "0.027" "False" "1.766" "4" "1" "1" "1" "426" "46.4" "8.27" "2.24" "1" "cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf03165, Pf03166" "4092" "ENSG00000101665" "SMAD7" "B7Z773; hsa:4092; K7EQ10; O14740; O15105; Q6DK23" "Apoptosis-related network due to altered Notch3 in ovarian cancer; Lung fibrosis; TGF-beta signaling pathway; Hfe effect on hepcidin production; Embryonic stem cell pluripotency pathways; Nonalcoholic fatty liver disease; TGF-beta receptor signaling in skeletal dysplasias; Neuroinflammation and glutamatergic signaling; HDAC6 interactions in the central nervous system; TGF-beta receptor signaling" "UCH proteinases; Ub-specific processing proteases; Signaling by BMP; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription; Interferon gamma signaling; Downregulation of TGF-beta receptor signaling; Downregulation of SMAD2/3:SMAD4 transcriptional activity" "17" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8812231068317453171" "False" "Medium" "IsMasterProtein" "Q14114" "Low-density lipoprotein receptor-related protein 8 OS=Homo sapiens OX=9606 GN=LRP8 PE=1 SV=4" "0.027" "False" "1.763" "1" "1" "2" "1" "963" "105.6" "5.05" "5.97" "1" "cell-cell signaling;cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00057, Pf00058, Pf07645, Pf14670" "7804" "ENSG00000157193" "LRP8" "B1AMT6; B1AMT7; B1AMT8; hsa:7804; O14968; Q14114; Q86V27; Q99876; Q9BR78" "Neurogenesis regulation in the olfactory epithelium" "Platelet sensitization by LDL; Retinoid metabolism and transport" "3" "0" "1.184" "1.259" "1.012" "1.145" "1.220" "0.925" "1.058" "1.193" "0.879" "162.5" "192.4" "204.7" "164.4" "186.1" "198.2" "150.3" "171.9" "193.9" "142.8" "" "" "" "" "" "" "" "" "" "" "146.1" "155.7" "185.1" "160.5" "153.5" "198.2" "112.5" "151.9" "173.5" "51.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "174890582361542950" "False" "Medium" "IsMasterProtein" "Q03052" "POU domain, class 3, transcription factor 1 OS=Homo sapiens OX=9606 GN=POU3F1 PE=1 SV=3" "0.027" "False" "1.763" "5" "1" "1" "1" "451" "45.5" "7.74" "2.83" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "5453" "ENSG00000185668" "POU3F1" "hsa:5453; Q03052; Q5TAG2" "" "Formation of the anterior neural plate; Formation of the posterior neural plate; EGR2 and SOX10-mediated initiation of Schwann cell myelination" "3" "0" "0.836" "0.806" "0.858" "0.849" "0.860" "1.006" "0.859" "0.945" "0.630" "61.2" "51.2" "49.3" "52.5" "52.0" "52.6" "61.5" "52.6" "57.8" "38.6" "" "" "" "" "" "" "" "" "" "" "55.0" "41.4" "44.6" "51.2" "42.9" "52.6" "46.1" "46.4" "51.7" "13.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3436560803263431899" "False" "Medium" "IsMasterProtein" "P14921" "Protein C-ets-1 OS=Homo sapiens OX=9606 GN=ETS1 PE=1 SV=1" "0.028" "False" "1.760" "2" "1" "1" "1" "441" "50.4" "5.19" "3.24" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00178, Pf02198, Pf19525" "2113" "ENSG00000134954" "ETS1" "A9UL17; F5GYX9; hsa:2113; P14921; Q14278; Q16080; Q6N087; Q96AC5" "Neural crest differentiation; B cell receptor signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; TGF-beta signaling pathway; VEGFA-VEGFR2 signaling; MET in type 1 papillary renal cell carcinoma; Ras signaling; Non-genomic actions of 1,25 dihydroxyvitamin D3; Melanoma; Extrafollicular and follicular B cell activation by SARS-CoV-2" "Oncogene Induced Senescence" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4230519549884410634" "False" "Medium" "IsMasterProtein" "P15309" "Prostatic acid phosphatase OS=Homo sapiens OX=9606 GN=ACP3 PE=1 SV=3" "0.028" "False" "1.753" "2" "1" "1" "1" "386" "44.5" "6.24" "2.36" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00328" "55" "ENSG00000014257" "ACP3" "D3DNC6; hsa:55; P15309; Q5FBY0; Q96KY0; Q96QK9; Q96QM0" "" "Neutrophil degranulation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4955977949004154122" "False" "Medium" "IsMasterProtein" "Q9NRW3" "DNA dC->dU-editing enzyme APOBEC-3C OS=Homo sapiens OX=9606 GN=APOBEC3C PE=1 SV=2" "0.028" "False" "1.750" "7" "1" "1" "1" "190" "22.8" "7.59" "0.00" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "other molecular function" "Pf18782" "27350" "ENSG00000244509" "APOBEC3C" "B2R884; hsa:27350; Q5JZ92; Q7Z2N7; Q96F12; Q9NRW3" "" "Formation of the Editosome" "2" "0" "1.076" "0.793" "0.762" "1.226" "1.003" "1.139" "0.899" "0.892" "1.314" "53.6" "57.7" "42.5" "40.8" "65.7" "53.7" "61.1" "48.2" "47.8" "70.4" "" "" "" "" "" "" "" "" "" "" "48.2" "46.7" "38.4" "39.9" "54.2" "53.7" "45.7" "42.6" "42.8" "25.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-949973540921292373" "False" "Medium" "IsMasterProtein" "P40425" "Pre-B-cell leukemia transcription factor 2 OS=Homo sapiens OX=9606 GN=PBX2 PE=1 SV=2" "0.028" "False" "1.748" "3" "1" "1" "1" "430" "45.9" "7.56" "2.92" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03792, Pf05920" "5089" "ENSG00000204304; ENSG00000206315; ENSG00000224952; ENSG00000225987; ENSG00000232005; ENSG00000236353; ENSG00000237344" "PBX2" "A2BFJ2; hsa:5089; P40425" "" "" "0" "0" "0.829" "0.988" "0.804" "0.929" "0.951" "0.846" "0.854" "0.809" "1.302" "241.0" "199.9" "238.2" "193.7" "223.9" "229.1" "203.8" "205.9" "194.9" "313.8" "" "" "" "" "" "" "" "" "" "" "216.7" "161.8" "215.5" "189.1" "184.8" "229.1" "152.6" "181.8" "174.4" "112.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5951829502980748262" "False" "Medium" "IsMasterProtein" "Q92989" "Polyribonucleotide 5'-hydroxyl-kinase Clp1 OS=Homo sapiens OX=9606 GN=CLP1 PE=1 SV=1" "0.028" "False" "1.747" "2" "1" "1" "1" "425" "47.6" "6.62" "2.72" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus" "kinase activity;other molecular function" "Pf06807, Pf16573, Pf16575" "10978" "ENSG00000172409" "CLP1" "B2R7J6; B4DTI8; hsa:10978; Q92989" "mRNA processing" "tRNA processing in the nucleus; mRNA 3'-end processing; RNA Polymerase II Transcription Termination; Processing of Intronless Pre-mRNAs" "6" "0" "1.291" "1.124" "1.251" "1.164" "1.125" "1.232" "1.279" "1.038" "2.269" "63.5" "82.0" "71.3" "79.4" "73.9" "71.4" "78.2" "81.2" "65.9" "144.0" "" "" "" "" "" "" "" "" "" "" "57.1" "66.3" "64.5" "77.5" "61.0" "71.4" "58.6" "71.7" "59.0" "51.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7884358778793776870" "False" "Medium" "IsMasterProtein" "P61968" "LIM domain transcription factor LMO4 OS=Homo sapiens OX=9606 GN=LMO4 PE=1 SV=1" "0.028" "False" "1.746" "5" "1" "1" "1" "165" "18.0" "8.34" "2.72" "1" "cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00412" "8543" "ENSG00000143013" "LMO4" "D3DT23; hsa:8543; O00158; O88894; P61968" "" "" "0" "0" "1.067" "0.957" "0.962" "1.053" "1.177" "0.968" "1.105" "1.087" "0.811" "81.1" "86.5" "77.6" "78.0" "85.4" "95.4" "78.5" "89.6" "88.2" "65.7" "" "" "" "" "" "" "" "" "" "" "72.9" "70.0" "70.2" "76.1" "70.5" "95.4" "58.8" "79.1" "78.9" "23.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7932092047749644365" "False" "Medium" "IsMasterProtein" "Q15831" "Serine/threonine-protein kinase STK11 OS=Homo sapiens OX=9606 GN=STK11 PE=1 SV=1" "0.028" "False" "1.744" "2" "1" "1" "1" "433" "48.6" "7.43" "2.73" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "enzyme regulator activity;kinase activity;other molecular function" "Pf00069" "6794" "ENSG00000118046" "STK11" "B2RBX7; E7EW76; hsa:6794; Q15831" "AMP-activated protein kinase signaling; Polycystic kidney disease pathway; mir-124 predicted interactions with cell cycle and differentiation ; ATM signaling in development and disease ; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway; Head and neck squamous cell carcinoma; Female steroid hormones in cardiomyocyte energy metabolism; ADHD and autism (ASD) linked metabolic pathways and SNP" "Regulation of TP53 Activity through Phosphorylation; Energy dependent regulation of mTOR by LKB1-AMPK; FOXO-mediated transcription of cell death genes; AMPK inhibits chREBP transcriptional activation activity" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5958317661100733671" "False" "Medium" "IsMasterProtein" "Cont_Q32KY0" "Apolipoprotein D OS=Bos taurus OX=9913 GN=APOD PE=2 SV=1" "0.028" "True" "1.743" "4" "1" "1" "1" "189" "21.4" "4.84" "2.26" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;translational apparatus;other cell component" "other molecular function" "Pf00061" "613972" "" "APOD" "bta:613972; Q32KY0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-171155120180448738" "False" "Medium" "IsMasterProtein" "Q96QU6" "1-aminocyclopropane-1-carboxylate synthase-like protein 1 OS=Homo sapiens OX=9606 GN=ACCS PE=1 SV=1" "0.029" "False" "1.734" "1" "1" "2" "1" "501" "57.3" "6.43" "2.94" "1" "other metabolic processes" "" "other molecular function" "Pf00155" "84680" "ENSG00000110455" "ACCS" "B4E219; hsa:84680; Q8WUL4; Q96LX5; Q96QU6" "11p11.2 copy number variation syndrome" "" "1" "0" "0.809" "1.124" "0.767" "0.894" "0.740" "0.852" "0.807" "0.892" "0.724" "195.2" "157.9" "219.3" "149.7" "174.4" "144.3" "166.2" "157.5" "174.1" "141.3" "" "" "" "" "" "" "" "" "" "" "175.5" "127.8" "198.3" "146.1" "144.0" "144.3" "124.5" "139.1" "155.8" "50.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5232175681869918932" "False" "Medium" "IsMasterProtein" "Q14678" "KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens OX=9606 GN=KANK1 PE=1 SV=3" "0.029" "False" "1.732" "1" "1" "1" "1" "1352" "147.2" "5.30" "2.55" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf00023, Pf12075" "23189" "ENSG00000107104" "KANK1" "A2A2W8; D3DRH3; hsa:23189; Q14678; Q5W0W0; Q8IY65; Q8WX74" "VEGFA-VEGFR2 signaling" "Estrogen-dependent gene expression; Signaling by membrane-tethered fusions of PDGFRA or PDGFRB" "3" "0" "1.231" "1.352" "1.033" "1.114" "1.075" "0.957" "1.198" "1.155" "2.440" "37.1" "45.7" "50.2" "38.4" "41.4" "39.9" "35.5" "44.5" "42.9" "90.6" "" "" "" "" "" "" "" "" "" "" "33.4" "37.0" "45.4" "37.4" "34.1" "39.9" "26.6" "39.3" "38.3" "32.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-978356630806365495" "False" "Medium" "IsMasterProtein" "Q969U6" "F-box/WD repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=FBXW5 PE=1 SV=1" "0.029" "False" "1.729" "2" "1" "1" "1" "566" "63.9" "6.33" "1.72" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00400, Pf12937" "54461" "ENSG00000159069" "FBXW5" "B2RDZ6; hsa:54461; Q59ET5; Q5SPZ8; Q5SPZ9; Q5SQ00; Q5SQ02; Q5SQ03; Q5SQ04; Q8WY79; Q969U6; Q96GJ6; Q9BSU8; Q9H6A8; Q9HBQ6; Q9NSZ3" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation; Association of TriC/CCT with target proteins during biosynthesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1805592529693250649" "False" "Medium" "IsMasterProtein" "Q9BYE7" "Polycomb group RING finger protein 6 OS=Homo sapiens OX=9606 GN=PCGF6 PE=1 SV=2" "0.029" "False" "1.724" "2" "1" "1" "1" "350" "39.0" "4.97" "2.77" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf13923, Pf16207" "84108" "ENSG00000156374" "PCGF6" "A8K3R4; hsa:84108; Q5SYD1; Q5SYD6; Q96ID9; Q96SJ1; Q9BYE7" "" "Transcriptional Regulation by E2F6" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6074544366636996297" "False" "Medium" "IsMasterProtein" "Q8TD17" "Zinc finger protein 398 OS=Homo sapiens OX=9606 GN=ZNF398 PE=1 SV=1" "0.029" "False" "1.721" "2" "1" "1" "1" "642" "71.3" "6.67" "2.23" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13913" "57541" "ENSG00000197024" "ZNF398" "A8K384; B4E377; hsa:57541; Q8TD17; Q8TD18; Q9P2K7; Q9UDV8" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "Not Found" "1" "" "-9005448150374041953" "False" "Medium" "IsMasterProtein" "Q9UBN6" "Tumor necrosis factor receptor superfamily member 10D OS=Homo sapiens OX=9606 GN=TNFRSF10D PE=1 SV=2" "0.029" "False" "1.721" "3" "1" "1" "1" "386" "41.8" "6.54" "2.14" "1" "signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00020" "8793" "ENSG00000173530" "TNFRSF10D" "B2R8W0; hsa:8793; Q9UBN6; Q9Y6Q4" "Apoptosis modulation and signaling; p53 transcriptional gene network" "Cell surface interactions at the vascular wall; TP53 Regulates Transcription of Death Receptors and Ligands; TRAIL signaling" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5711081481514943927" "False" "Medium" "IsMasterProtein" "P07858" "Cathepsin B OS=Homo sapiens OX=9606 GN=CTSB PE=1 SV=3" "0.029" "False" "1.719" "5" "1" "1" "1" "339" "37.8" "6.30" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00112, Pf08127" "1508" "ENSG00000164733; ENSG00000285132" "CTSB" "B3KQR5; B3KRR5; hsa:1508; P07858; Q503A6; Q96D87" "Ebola virus infection in host; 8p23.1 copy number variation syndrome" "MHC class II antigen presentation; Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Neutrophil degranulation; Trafficking and processing of endosomal TLR" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3153284644791767852" "False" "Medium" "IsMasterProtein" "Q9NX05" "Constitutive coactivator of PPAR-gamma-like protein 2 OS=Homo sapiens OX=9606 GN=FAM120C PE=1 SV=4" "0.030" "False" "1.702" "1" "1" "1" "1" "1096" "120.5" "9.03" "2.87" "1" "" "nucleus" "" "" "54954" "ENSG00000184083" "FAM120C" "B2RMT7; hsa:54954; Q9NX05" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3128550714862144269" "False" "Medium" "IsMasterProtein" "Q9H7E2" "Tudor domain-containing protein 3 OS=Homo sapiens OX=9606 GN=TDRD3 PE=1 SV=1" "0.030" "False" "1.699" "2" "1" "1" "1" "651" "73.1" "9.23" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00567, Pf00627, Pf08585" "81550" "ENSG00000083544" "TDRD3" "B2MWP9; hsa:81550; Q53XA6; Q6P992; Q9H7E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4301778236413412873" "False" "Medium" "IsMasterProtein" "Q6UXG8" "Butyrophilin-like protein 9 OS=Homo sapiens OX=9606 GN=BTNL9 PE=1 SV=1" "0.030" "False" "1.697" "1" "1" "2" "1" "535" "59.7" "6.44" "4.48" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf00622, Pf07686, Pf13765" "153579" "ENSG00000165810" "BTNL9" "A6NL42; hsa:153579; Q6P660; Q6UXG8; Q96DM5" "" "Butyrophilin (BTN) family interactions" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "644773840200945729" "False" "Medium" "IsMasterProtein" "Q96L94" "Sorting nexin-22 OS=Homo sapiens OX=9606 GN=SNX22 PE=1 SV=1" "0.030" "False" "1.693" "4" "1" "1" "1" "193" "22.1" "9.55" "2.73" "1" "transport" "other membranes" "other molecular function" "Pf00787" "79856" "ENSG00000157734" "SNX22" "hsa:79856; Q8WUS9; Q96L94; Q9H844" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5037587116329187279" "False" "Medium" "IsMasterProtein" "Q8N0U4" "Protein FAM185A OS=Homo sapiens OX=9606 GN=FAM185A PE=1 SV=3" "0.030" "False" "1.684" "3" "1" "1" "1" "392" "42.3" "7.97" "2.28" "1" "" "" "" "Pf13349" "222234" "ENSG00000222011" "FAM185A" "A8MUR7; B4DQD3; C9IZ91; hsa:222234; Q8N0U4" "" "" "0" "0" "1.176" "1.033" "0.783" "0.927" "0.870" "0.911" "1.100" "0.814" "0.907" "60.2" "70.8" "62.1" "47.1" "55.8" "52.4" "54.8" "66.2" "48.9" "54.6" "" "" "" "" "" "" "" "" "" "" "54.1" "57.2" "56.2" "46.0" "46.0" "52.4" "41.0" "58.4" "43.8" "19.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8504689738561094897" "False" "Medium" "IsMasterProtein" "O43303" "Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens OX=9606 GN=CCP110 PE=1 SV=3" "0.030" "False" "1.680" "1" "1" "1" "1" "1012" "113.4" "8.65" "2.62" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;other cell component" "" "Pf16025" "9738" "ENSG00000103540" "CCP110" "B7WP23; hsa:9738; O43303; O43335; Q68DV9; Q8NE13" "Joubert syndrome" "Ub-specific processing proteases; Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2; RHOV GTPase cycle" "10" "0" "0.897" "0.842" "0.999" "0.913" "0.989" "0.942" "1.043" "0.938" "1.037" "263.8" "236.6" "222.1" "263.6" "240.7" "260.9" "248.5" "275.1" "247.3" "273.4" "" "" "" "" "" "" "" "" "" "" "237.1" "191.5" "200.9" "257.3" "198.7" "260.9" "186.1" "243.0" "221.3" "97.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1177482447512558462" "False" "Medium" "IsMasterProtein" "Q9NUV9" "GTPase IMAP family member 4 OS=Homo sapiens OX=9606 GN=GIMAP4 PE=1 SV=1" "0.031" "False" "1.676" "2" "1" "1" "1" "329" "37.5" "7.81" "2.71" "1" "" "cytosol;other cell component" "other molecular function" "Pf04548" "55303" "ENSG00000133574" "GIMAP4" "hsa:55303; Q9NUV9" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8775009623055408679" "False" "Medium" "IsMasterProtein" "Q5BKY9" "Protein FAM133B OS=Homo sapiens OX=9606 GN=FAM133B PE=1 SV=1" "0.030" "False" "1.676" "6" "1" "1" "1" "247" "28.4" "10.02" "0.00" "1" "" "" "" "" "257415" "ENSG00000234545" "FAM133B" "B2R994; hsa:257415; Q05D67; Q5BKY9; Q6P5S6; Q8N0W8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8625580668015925346" "False" "Medium" "IsMasterProtein" "Q9HCK8" "Chromodomain-helicase-DNA-binding protein 8 OS=Homo sapiens OX=9606 GN=CHD8 PE=1 SV=5" "0.031" "False" "1.664" "0" "1" "1" "1" "2581" "290.3" "6.47" "2.48" "1" "cell-cell signaling;cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385, Pf07533" "57680" "ENSG00000100888" "CHD8" "hsa:57680; Q4G0D8; Q68DQ0; Q6DKH9; Q6P440; Q6ZNL7; Q8N3Z9; Q8NCY4; Q8TBR9; Q96F26; Q9HCK8" "lncRNA in canonical Wnt signaling and colorectal cancer; Wnt signaling; ncRNAs involved in Wnt signaling in hepatocellular carcinoma; Pleural mesothelioma" "Deactivation of the beta-catenin transactivating complex" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-268606970100877469" "False" "Medium" "IsMasterProtein" "Q15834" "Coiled-coil domain-containing protein 85B OS=Homo sapiens OX=9606 GN=CCDC85B PE=1 SV=2" "0.031" "False" "1.663" "3" "1" "1" "1" "202" "22.1" "5.08" "2.54" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf10226" "11007" "ENSG00000175602" "CCDC85B" "B2R598; hsa:11007; Q15834; Q96HA0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1540404723274759842" "False" "Medium" "IsMasterProtein" "P52333" "Tyrosine-protein kinase JAK3 OS=Homo sapiens OX=9606 GN=JAK3 PE=1 SV=2" "0.031" "False" "1.663" "1" "1" "1" "1" "1124" "125.0" "7.18" "3.10" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;other cytoplasmic organelle" "signal transduction activity or receptor binding;kinase activity;other molecular function" "Pf07714, Pf17887, Pf18377, Pf18379" "3718" "ENSG00000105639" "JAK3" "hsa:3718; P52333; Q13259; Q13260; Q13611; Q8N1E8; Q99699; Q9Y6S2" "IL-7 signaling pathway; IL-9 signaling pathway; Oncostatin M signaling pathway; Chemokine signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; IL-4 signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Non-small cell lung cancer; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Measles virus infection; Hepatitis B infection; IL-2 signaling pathway" "Potential therapeutics for SARS; Interleukin receptor SHC signaling; RAF/MAP kinase cascade; Interleukin-7 signaling; Signaling by ALK; Interleukin-4 and Interleukin-13 signaling; Interleukin-20 family signaling; Interleukin-2 signaling; Interleukin-15 signaling; Interleukin-9 signaling; Interleukin-21 signaling" "24" "0" "0.798" "1.040" "0.806" "0.762" "0.763" "0.762" "0.896" "0.828" "0.781" "335.5" "267.7" "348.8" "270.4" "255.6" "256.0" "255.6" "300.8" "278.0" "261.9" "" "" "" "" "" "" "" "" "" "" "301.7" "216.6" "315.5" "264.0" "211.0" "256.0" "191.4" "265.7" "248.7" "93.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1750728532915828857" "False" "Medium" "IsMasterProtein" "P26010" "Integrin beta-7 OS=Homo sapiens OX=9606 GN=ITGB7 PE=1 SV=1" "0.031" "False" "1.662" "1" "1" "1" "1" "798" "86.8" "6.04" "3.38" "1" "cell adhesion;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00362, Pf07974, Pf08725, Pf17205" "3695" "ENSG00000139626" "ITGB7" "hsa:3695; P26010; Q9UCP7; Q9UCS7" "Integrin-mediated cell adhesion; Arrhythmogenic right ventricular cardiomyopathy; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms" "Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell; Integrin cell surface interactions" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4110567019566568697" "False" "Medium" "IsMasterProtein" "Q9P0U4" "CXXC-type zinc finger protein 1 OS=Homo sapiens OX=9606 GN=CXXC1 PE=1 SV=2" "0.031" "False" "1.657" "2" "1" "1" "1" "656" "75.7" "8.24" "0.00" "1" "other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf02008, Pf12269" "30827" "ENSG00000154832" "CXXC1" "B2RC03; hsa:30827; Q8N2W4; Q96BC8; Q9P0U4; Q9P2V7" "Male infertility" "Formation of WDR5-containing histone-modifying complexes; XBP1(S) activates chaperone genes" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1635055545262344476" "False" "Medium" "IsMasterProtein" "Q9UER7" "Death domain-associated protein 6 OS=Homo sapiens OX=9606 GN=DAXX PE=1 SV=2" "0.031" "False" "1.650" "1" "1" "1" "1" "740" "81.3" "4.87" "0.00" "1" "cell organization and biogenesis;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf03344, Pf20920" "1616" "ENSG00000204209; ENSG00000206206; ENSG00000206279; ENSG00000227046; ENSG00000231617" "DAXX" "B4E1I3; F5ANJ6; F5ANJ7; F5H082; hsa:1616; O14747; O15141; O15208; Q5STK9; Q9BWI3; Q9UER7" "Androgen receptor signaling pathway; Amyotrophic lateral sclerosis (ALS); Fas ligand pathway and stress induction of heat shock proteins; MAPK signaling pathway; p38 MAPK signaling pathway" "SUMOylation of transcription cofactors; HCMV Early Events; Inhibition of DNA recombination at telomere; Regulation of TP53 Degradation; Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations; Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3305508852960409357" "False" "Medium" "IsMasterProtein" "Cont_Q7SIH1" "Alpha-2-macroglobulin OS=Bos taurus OX=9913 GN=A2M PE=1 SV=2" "0.032" "True" "1.647" "1" "1" "1" "1" "1510" "167.5" "6.02" "2.45" "1" "" "non-structural extracellular" "enzyme regulator activity;other molecular function" "Pf00207, Pf01835, Pf07677, Pf07678, Pf07703, Pf17789, Pf17791" "513856" "" "A2M" "A8E647; bta:513856; Q7SIH1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1006900541340896010" "False" "Medium" "IsMasterProtein" "Q2M2Z5" "Centrosomal protein kizuna OS=Homo sapiens OX=9606 GN=KIZ PE=1 SV=2" "0.033" "False" "1.630" "1" "1" "1" "1" "673" "75.1" "5.62" "2.47" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "other molecular function" "" "55857" "ENSG00000088970" "KIZ" "B4DDE9; B4DK54; hsa:55857; Q2M2Z5; Q4G0M8; Q4G0S5; Q5BKY3; Q6P0M6; Q71ME0; Q9NZ35" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6929037919214983721" "False" "Medium" "IsMasterProtein" "Q8IZE3" "Protein-associating with the carboxyl-terminal domain of ezrin OS=Homo sapiens OX=9606 GN=SCYL3 PE=1 SV=3" "0.033" "False" "1.630" "2" "1" "1" "1" "742" "82.8" "5.05" "0.00" "1" "stress response;developmental processes;other biological processes" "other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf07714" "57147" "ENSG00000000457" "SCYL3" "A8K8Z2; hsa:57147; Q5THA6; Q5THA8; Q8IZE3; Q8IZN9; Q96C56; Q9UBK6" "" "" "0" "0" "0.891" "0.973" "1.002" "0.962" "0.899" "1.038" "0.934" "0.771" "0.942" "187.1" "166.7" "182.0" "187.4" "180.0" "168.1" "194.1" "174.8" "144.3" "176.2" "" "" "" "" "" "" "" "" "" "" "168.2" "134.9" "164.6" "182.9" "148.5" "168.1" "145.4" "154.4" "129.1" "62.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8115979113467782463" "False" "Medium" "IsMasterProtein" "Q9Y2R4" "Probable ATP-dependent RNA helicase DDX52 OS=Homo sapiens OX=9606 GN=DDX52 PE=1 SV=4" "0.033" "False" "1.630" "1" "1" "1" "1" "599" "67.4" "9.67" "2.74" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus" "other molecular function" "Pf00270, Pf00271" "11056" "ENSG00000277594; ENSG00000278053" "DDX52" "hsa:11056; Q86YG1; Q8N213; Q9NVE0; Q9Y2R4; Q9Y482" "Orexin receptor pathway; 17q12 copy number variation syndrome" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5143535617621486292" "False" "Medium" "IsMasterProtein" "Q8IXK0" "Polyhomeotic-like protein 2 OS=Homo sapiens OX=9606 GN=PHC2 PE=1 SV=1" "0.033" "False" "1.626" "1" "1" "1" "1" "858" "90.7" "8.69" "2.14" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00536, Pf16616, Pf21319" "1912" "ENSG00000134686" "PHC2" "A1L4Q1; A8KA40; D3DPR2; hsa:1912; Q2TAL3; Q5T0C1; Q6NUJ6; Q6ZQR1; Q8IXK0; Q8N306; Q8TAG8; Q96BL4; Q9Y4Y7" "" "SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; Oxidative Stress Induced Senescence; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5703781762481200822" "False" "Medium" "IsMasterProtein" "Q04941" "Proteolipid protein 2 OS=Homo sapiens OX=9606 GN=PLP2 PE=1 SV=1" "0.033" "False" "1.626" "9" "1" "1" "1" "152" "16.7" "7.24" "2.05" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf01284" "5355" "ENSG00000102007" "PLP2" "A6NDT7; hsa:5355; Q04941; Q32MM8" "" "" "0" "0" "0.935" "0.957" "0.780" "0.810" "1.077" "0.632" "0.801" "0.937" "1.247" "36.5" "34.1" "34.9" "28.5" "29.6" "39.3" "23.1" "29.2" "34.2" "45.5" "" "" "" "" "" "" "" "" "" "" "32.8" "27.6" "31.6" "27.8" "24.4" "39.3" "17.3" "25.8" "30.6" "16.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4484612190120374131" "False" "Medium" "IsMasterProtein" "Q9Y6Y0" "Influenza virus NS1A-binding protein OS=Homo sapiens OX=9606 GN=IVNS1ABP PE=1 SV=3" "0.034" "False" "1.621" "2" "1" "1" "1" "642" "71.7" "5.53" "1.87" "1" "RNA metabolism OR transcription;other metabolic processes;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "" "Pf00651, Pf01344, Pf07707" "10625" "ENSG00000116679" "IVNS1ABP" "A8K8R6; hsa:10625; Q1G4T6; Q1G4T7; Q5TF75; Q6NW38; Q7LCG2; Q9NZX0; Q9Y480; Q9Y6Y0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8053794800816316585" "False" "Medium" "IsMasterProtein" "Q9UKU6" "Thyrotropin-releasing hormone-degrading ectoenzyme OS=Homo sapiens OX=9606 GN=TRHDE PE=1 SV=2" "0.034" "False" "1.620" "1" "1" "1" "1" "1069" "122.1" "6.99" "2.64" "1" "cell-cell signaling;protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf01433, Pf11838, Pf17900" "29953" "ENSG00000072657" "TRHDE" "A5PL19; H0YHU0; hsa:29953; Q6UWJ4; Q9UKU6" "" "" "0" "0" "0.869" "0.821" "0.793" "0.948" "0.865" "0.727" "0.803" "0.979" "0.754" "285.4" "248.1" "234.3" "226.2" "270.7" "247.0" "207.5" "229.2" "279.2" "215.3" "" "" "" "" "" "" "" "" "" "" "256.6" "200.7" "211.9" "220.8" "223.3" "247.0" "155.3" "202.5" "249.9" "76.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4772839766281477168" "False" "Medium" "IsMasterProtein" "Q6UXF7" "C-type lectin domain family 18 member B OS=Homo sapiens OX=9606 GN=CLEC18B PE=2 SV=2" "0.034" "False" "1.620" "2" "1" "1" "1" "455" "50.5" "8.00" "0.00" "1" "" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00059, Pf00188" "497190" "ENSG00000140839" "CLEC18B" "B4DF90; hsa:497190; Q6UXF7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8218797192216084212" "False" "Medium" "IsMasterProtein" "P08581" "Hepatocyte growth factor receptor OS=Homo sapiens OX=9606 GN=MET PE=1 SV=4" "0.034" "False" "1.618" "1" "1" "1" "1" "1390" "155.4" "7.33" "0.00" "1" "other metabolic processes;transport;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf01403, Pf01437, Pf01833, Pf07714" "4233" "ENSG00000105976" "MET" "A1L467; B5A932; E7EQ94; hsa:4233; O60366; P08581; Q12875; Q9UDX7; Q9UPL8" "Glioblastoma signaling pathways; Extracellular vesicle-mediated signaling in recipient cells; Focal adhesion; Hepatocyte growth factor receptor signaling; TGF-beta signaling pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; MET in type 1 papillary renal cell carcinoma; Ras signaling; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; EGFR tyrosine kinase inhibitor resistance; Pleural mesothelioma; GDNF signaling; TAR syndrome" "PIP3 activates AKT signaling; Constitutive Signaling by Aberrant PI3K in Cancer; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling; RAF/MAP kinase cascade; Negative regulation of MET activity; InlB-mediated entry of Listeria monocytogenes into host cell; MET activates PTK2 signaling; Sema4D mediated inhibition of cell attachment and migration; MET Receptor Activation; MET activates RAS signaling; MET interacts with TNS proteins; MET activates PI3K/AKT signaling; MET activates PTPN11; MET activates RAP1 and RAC1; MET receptor recycling; MET activates STAT3; MECP2 regulates neuronal receptors and channels; Drug-mediated inhibition of MET activation" "33" "0" "1.007" "1.086" "1.126" "1.219" "1.154" "1.243" "1.094" "1.202" "0.747" "75.5" "76.0" "81.9" "85.0" "92.0" "87.1" "93.8" "82.6" "90.7" "56.4" "" "" "" "" "" "" "" "" "" "" "67.8" "61.5" "74.1" "83.0" "75.9" "87.1" "70.2" "72.9" "81.1" "20.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8835583499826940302" "False" "Medium" "IsMasterProtein" "Q86YN6" "Peroxisome proliferator-activated receptor gamma coactivator 1-beta OS=Homo sapiens OX=9606 GN=PPARGC1B PE=1 SV=2" "0.034" "False" "1.617" "2" "1" "1" "1" "1023" "113.2" "5.02" "2.55" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;nucleus" "nucleic acid binding activity;other molecular function" "Pf00076" "133522" "ENSG00000155846" "PPARGC1B" "A2RUM8; A2RUN0; B3KVW0; hsa:133522; Q86YN3; Q86YN4; Q86YN5; Q86YN6; Q8N1N9; Q8TDE4; Q8TDE5" "AMP-activated protein kinase signaling; Energy metabolism; Sterol regulatory element-binding proteins (SREBP) signaling; Differentiation of white and brown adipocyte; Mitochondrial gene expression; FOXA2 pathway; Sudden infant death syndrome (SIDS) susceptibility pathways; Prostaglandin synthesis and regulation" "PPARA activates gene expression; Regulation of RUNX2 expression and activity; Transcriptional activation of mitochondrial biogenesis" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7162777822988383217" "False" "Medium" "IsMasterProtein" "A0AAG2TU83" "Uncharacterized protein OS=Homo sapiens OX=9606 PE=4 SV=1" "0.034" "False" "1.616" "10" "1" "2" "1" "120" "13.7" "9.38" "5.64" "1" "" "" "" "" "" "" "" "" "" "" "0" "0" "0.703" "1.108" "0.583" "0.518" "0.714" "0.499" "0.655" "0.540" "0.511" "154.4" "108.6" "171.1" "90.0" "79.9" "110.2" "77.1" "101.2" "83.4" "79.0" "" "" "" "" "" "" "" "" "" "" "138.9" "87.9" "154.8" "87.9" "66.0" "110.2" "57.7" "89.4" "74.6" "28.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8486015732534254879" "False" "Medium" "IsMasterProtein" "Q7Z5W3" "RNA 5'-monophosphate methyltransferase OS=Homo sapiens OX=9606 GN=BCDIN3D PE=1 SV=1" "0.034" "False" "1.613" "2" "1" "1" "1" "292" "33.2" "6.70" "2.30" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf06859" "144233" "ENSG00000186666" "BCDIN3D" "A8K829; hsa:144233; Q7Z5W3" "" "MicroRNA (miRNA) biogenesis" "1" "0" "1.017" "1.049" "1.028" "1.081" "1.184" "1.222" "1.208" "1.016" "0.905" "37.5" "38.1" "39.3" "38.5" "40.5" "44.4" "45.8" "45.3" "38.1" "33.9" "" "" "" "" "" "" "" "" "" "" "33.7" "30.8" "35.6" "37.6" "33.4" "44.4" "34.3" "40.0" "34.1" "12.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2959311852295820305" "False" "Medium" "IsMasterProtein" "Q6TFL3" "Coiled-coil domain-containing protein 171 OS=Homo sapiens OX=9606 GN=CCDC171 PE=1 SV=1" "0.034" "False" "1.610" "1" "1" "2" "1" "1326" "152.7" "6.81" "2.17" "1" "" "" "" "" "203238" "ENSG00000164989" "CCDC171" "B7ZM22; Q5SU58; Q6P1W1; Q6TFL3; Q6ZR13; Q8N1Z4; Q8N8L3; Q8TBR2" "" "" "0" "0" "0.821" "0.983" "1.126" "1.213" "0.964" "1.091" "1.125" "1.119" "1.401" "34.1" "28.0" "33.5" "38.4" "41.4" "32.9" "37.2" "38.4" "38.2" "47.8" "" "" "" "" "" "" "" "" "" "" "30.7" "22.7" "30.3" "37.5" "34.1" "32.9" "27.8" "33.9" "34.1" "17.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8889272797840220039" "False" "Medium" "IsMasterProtein" "Q9UBZ9" "DNA repair protein REV1 OS=Homo sapiens OX=9606 GN=REV1 PE=1 SV=1" "0.034" "False" "1.610" "1" "1" "1" "1" "1251" "138.2" "8.51" "1.75" "1" "DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00533, Pf00817, Pf11799, Pf14377, Pf16727, Pf21704" "51455" "ENSG00000135945" "REV1" "hsa:51455; O95941; Q53SI7; Q9C0J4; Q9NUP2; Q9UBZ9" "DNA repair pathways, full network" "Termination of translesion DNA synthesis; Translesion synthesis by REV1; Translesion synthesis by POLK; Translesion synthesis by POLI" "5" "0" "0.812" "0.936" "0.754" "0.744" "0.789" "0.876" "0.860" "0.941" "0.685" "52.1" "42.3" "48.7" "39.3" "38.7" "41.1" "45.6" "44.8" "49.0" "35.7" "" "" "" "" "" "" "" "" "" "" "46.8" "34.2" "44.1" "38.3" "32.0" "41.1" "34.2" "39.6" "43.9" "12.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9078739343281468002" "False" "Medium" "IsMasterProtein" "Q9NNX1" "Tuftelin OS=Homo sapiens OX=9606 GN=TUFT1 PE=1 SV=1" "0.034" "False" "1.608" "3" "1" "1" "1" "390" "44.2" "6.00" "0.00" "1" "signal transduction;other biological processes" "non-structural extracellular;other cell component" "extracellular structural activity;bone, tooth or skin structural activity" "" "7286" "ENSG00000143367" "TUFT1" "B2RD57; D3DV21; D3DV22; hsa:7286; Q5T384; Q5T385; Q9BU28; Q9H5L1; Q9NNX1" "" "" "0" "0" "1.014" "1.105" "0.857" "1.023" "1.103" "0.919" "0.888" "1.059" "1.030" "181.4" "183.9" "200.5" "155.5" "185.5" "200.0" "166.8" "161.1" "192.1" "186.8" "" "" "" "" "" "" "" "" "" "" "163.1" "148.8" "181.3" "151.8" "153.1" "200.0" "124.9" "142.3" "171.9" "66.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-957867492455840150" "False" "Medium" "IsMasterProtein" "Q9NR82" "Potassium voltage-gated channel subfamily KQT member 5 OS=Homo sapiens OX=9606 GN=KCNQ5 PE=1 SV=3" "0.035" "False" "1.600" "1" "1" "1" "1" "932" "102.1" "9.48" "1.84" "1" "transport" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00520, Pf03520" "56479" "ENSG00000185760" "KCNQ5" "A6NKT6; A6PVT6; A8MSQ5; B4DS33; B5MC83; B7ZL37; F5GZV0; hsa:56479; Q17RE1; Q5VVP3; Q86W40; Q9NR82; Q9NRN0; Q9NYA6" "" "Voltage gated Potassium channels" "1" "0" "1.277" "1.000" "1.113" "1.314" "1.406" "1.285" "1.271" "1.214" "1.022" "46.0" "58.7" "46.0" "51.2" "60.4" "64.6" "59.1" "58.5" "55.8" "47.0" "" "" "" "" "" "" "" "" "" "" "41.3" "47.5" "41.6" "50.0" "49.9" "64.6" "44.2" "51.6" "49.9" "16.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3182776734112552640" "False" "Medium" "IsMasterProtein" "P41279" "Mitogen-activated protein kinase kinase kinase 8 OS=Homo sapiens OX=9606 GN=MAP3K8 PE=1 SV=2" "0.035" "False" "1.597" "2" "1" "1" "1" "467" "52.9" "5.81" "3.27" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol" "kinase activity;other molecular function" "Pf00069" "1326" "ENSG00000107968" "MAP3K8" "A8K2Q5; D3DRX1; hsa:1326; P41279; Q14275; Q5T855; Q9HC81" "TNF-alpha signaling pathway; Interleukin-1 (IL-1) structural pathway; MAPK signaling pathway; T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection; Angiopoietin-like protein 8 regulatory pathway; Insulin signaling; Modulators of TCR signaling and T cell activation; T-cell receptor signaling pathway; Toll-like receptor signaling pathway" "CD28 dependent PI3K/Akt signaling; MAP3K8 (TPL2)-dependent MAPK1/3 activation" "11" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4932179275381718129" "False" "Medium" "IsMasterProtein" "Q6UY01" "Leucine-rich repeat-containing protein 31 OS=Homo sapiens OX=9606 GN=LRRC31 PE=1 SV=1" "0.036" "False" "1.593" "2" "1" "1" "1" "552" "61.5" "6.02" "2.38" "1" "" "" "" "" "79782" "ENSG00000114248" "LRRC31" "B7ZL44; E5RJA9; hsa:79782; Q17RA3; Q6UY01; Q8N848; Q9H5N5; V9HW14" "" "" "0" "0" "0.890" "1.117" "0.977" "1.004" "0.937" "0.902" "1.004" "0.972" "0.894" "87.0" "77.4" "97.2" "85.0" "87.3" "81.5" "78.5" "87.3" "84.6" "77.7" "" "" "" "" "" "" "" "" "" "" "78.2" "62.6" "87.9" "83.0" "72.1" "81.5" "58.8" "77.1" "75.7" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7923817397987579375" "False" "Medium" "IsMasterProtein" "P04198" "N-myc proto-oncogene protein OS=Homo sapiens OX=9606 GN=MYCN PE=1 SV=2" "0.036" "False" "1.591" "2" "1" "1" "1" "464" "49.5" "5.66" "2.54" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010, Pf01056" "4613" "ENSG00000134323" "MYCN" "hsa:4613; P04198; Q53XS5; Q6LDT9" "Pathways affected in adenoid cystic carcinoma; Development of ureteric collection system; GDNF signaling" "Signaling by ALK" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7161908197236874210" "False" "Medium" "IsMasterProtein" "Q9BTV5" "Fibronectin type III and SPRY domain-containing protein 1 OS=Homo sapiens OX=9606 GN=FSD1 PE=1 SV=1" "0.036" "False" "1.587" "2" "1" "1" "1" "496" "55.8" "6.99" "1.76" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00041, Pf00622" "79187" "ENSG00000105255" "FSD1" "B2RDT0; hsa:79187; Q9BTV5; Q9BXN0; Q9HAG4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3758554991952715701" "False" "Medium" "IsMasterProtein" "Q9C0F1" "Centrosomal protein of 44 kDa OS=Homo sapiens OX=9606 GN=CEP44 PE=1 SV=2" "0.036" "False" "1.582" "3" "1" "1" "1" "390" "44.1" "5.21" "1.89" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf15007" "80817" "ENSG00000164118" "CEP44" "A8K8W9; A8MW11; B3KT53; D3DP42; hsa:80817; Q8IXZ4; Q9C0F1" "Genes related to primary cilium development (based on CRISPR)" "" "1" "0" "1.092" "0.870" "0.979" "1.000" "1.006" "1.263" "0.988" "0.903" "1.437" "90.6" "98.9" "78.8" "88.7" "90.6" "91.1" "114.4" "89.5" "81.8" "130.1" "" "" "" "" "" "" "" "" "" "" "81.4" "80.0" "71.3" "86.5" "74.7" "91.1" "85.7" "79.0" "73.2" "46.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4709802427439363093" "False" "Medium" "IsMasterProtein" "Q9NX36" "DnaJ homolog subfamily C member 28 OS=Homo sapiens OX=9606 GN=DNAJC28 PE=1 SV=2" "0.037" "False" "1.582" "2" "1" "1" "1" "388" "45.8" "9.55" "2.67" "1" "" "" "" "Pf00226, Pf09350" "54943" "ENSG00000177692; ENSG00000262911" "DNAJC28" "D3DSF2; hsa:54943; Q9NX36" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7515623990102163669" "False" "Medium" "IsMasterProtein" "P51161" "Gastrotropin OS=Homo sapiens OX=9606 GN=FABP6 PE=1 SV=2" "0.037" "False" "1.581" "7" "1" "1" "1" "128" "14.4" "6.80" "1.79" "1" "other metabolic processes;transport;other biological processes" "other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf14651" "2172" "ENSG00000170231" "FABP6" "hsa:2172; P51161; Q07DR7; Q8TBI3; Q9UGI7" "PPAR signaling pathway; Fatty acid transporters" "Triglyceride catabolism; Recycling of bile acids and salts; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis" "5" "0" "0.839" "0.998" "1.013" "0.986" "0.993" "0.987" "1.068" "0.926" "0.865" "70.6" "59.2" "70.5" "71.5" "69.6" "70.1" "69.7" "75.4" "65.4" "61.1" "" "" "" "" "" "" "" "" "" "" "63.5" "47.9" "63.8" "69.8" "57.4" "70.1" "52.2" "66.6" "58.5" "21.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1413134168628784763" "False" "Medium" "IsMasterProtein" "Q9Y2Q0" "Phospholipid-transporting ATPase IA OS=Homo sapiens OX=9606 GN=ATP8A1 PE=1 SV=1" "0.037" "False" "1.580" "1" "1" "1" "1" "1164" "131.3" "6.84" "2.53" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;other molecular function" "Pf00122, Pf13246, Pf16209, Pf16212" "10396" "ENSG00000124406" "ATP8A1" "hsa:10396; Q32M35; Q32M36; Q4W5J7; Q4W5P2; Q9Y2Q0" "Peptide GPCRs" "Neutrophil degranulation; Ion transport by P-type ATPases" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6903887554392062573" "False" "Medium" "IsMasterProtein" "P35226" "Polycomb complex protein BMI-1 OS=Homo sapiens OX=9606 GN=BMI1 PE=1 SV=2" "0.037" "False" "1.580" "2" "1" "1" "1" "326" "36.9" "8.63" "0.00" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf13923, Pf16207" "100532731; 648" "ENSG00000168283" "BMI1" "hsa:100532731; hsa:648; P35226; Q16030; Q5T8Z3; Q96F37" "Pleural mesothelioma; Interactions of natural killer cells in pancreatic cancer; CCL18 signaling pathway" "Oxidative Stress Induced Senescence; SUMOylation of DNA damage response and repair proteins; SUMOylation of chromatin organization proteins; SUMOylation of RNA binding proteins; SUMOylation of transcription cofactors; SUMOylation of DNA methylation proteins; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; Regulation of PTEN gene transcription; Transcriptional Regulation by E2F6" "12" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7100203530818565223" "False" "Medium" "IsMasterProtein" "O00443" "Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens OX=9606 GN=PIK3C2A PE=1 SV=2" "0.037" "False" "1.570" "0" "1" "2" "1" "1686" "190.6" "8.02" "6.29" "1" "cell organization and biogenesis;other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf00168, Pf00454, Pf00613, Pf00787, Pf00792, Pf00794" "5286" "ENSG00000011405" "PIK3C2A" "B0LPH2; B4E2G4; hsa:5286; O00443; Q14CQ9" "Glioblastoma signaling pathways; Angiopoietin-like protein 8 regulatory pathway; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; Microglia pathogen phagocytosis pathway; Osteoblast differentiation and related diseases; Insulin signaling; Regulation of actin cytoskeleton; DNA damage response (only ATM dependent)" "Golgi Associated Vesicle Biogenesis; Clathrin-mediated endocytosis; Synthesis of PIPs at the plasma membrane; Synthesis of PIPs at the Golgi membrane; Synthesis of PIPs at the early endosome membrane; Synthesis of PIPs at the late endosome membrane" "14" "0" "0.984" "0.915" "1.008" "0.934" "0.852" "0.944" "0.936" "0.906" "0.882" "475.1" "467.6" "434.7" "479.0" "443.6" "404.7" "448.5" "444.7" "430.5" "419.2" "" "" "" "" "" "" "" "" "" "" "427.1" "378.4" "393.2" "467.6" "366.0" "404.7" "335.8" "392.8" "385.2" "149.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5530400762788936201" "False" "Medium" "IsMasterProtein" "O43299" "AP-5 complex subunit zeta-1 OS=Homo sapiens OX=9606 GN=AP5Z1 PE=1 SV=2" "0.037" "False" "1.564" "1" "1" "1" "1" "807" "88.5" "7.01" "2.31" "1" "DNA metabolism;stress response;transport" "other membranes;nucleus;other cytoplasmic organelle;other cell component" "" "Pf14764" "9907" "ENSG00000242802" "AP5Z1" "hsa:9907; O43299; Q8N3X2; Q96H80" "" "" "0" "0" "1.098" "1.167" "1.118" "1.112" "1.150" "1.086" "1.143" "1.044" "1.133" "80.1" "88.0" "93.5" "89.6" "89.1" "92.1" "87.0" "91.6" "83.6" "90.8" "" "" "" "" "" "" "" "" "" "" "72.0" "71.2" "84.6" "87.5" "73.5" "92.1" "65.2" "80.9" "74.8" "32.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2171403269776386208" "False" "Medium" "IsMasterProtein" "Q16352" "Alpha-internexin OS=Homo sapiens OX=9606 GN=INA PE=1 SV=2" "0.037" "False" "1.564" "2" "1" "1" "1" "499" "55.4" "5.40" "1.88" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf00038, Pf04732" "9118" "ENSG00000148798" "INA" "B1AQK0; hsa:9118; Q16352; Q9BRC5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658427898063884792" "False" "Medium" "IsMasterProtein" "Q9P2N7" "Kelch-like protein 13 OS=Homo sapiens OX=9606 GN=KLHL13 PE=1 SV=3" "0.037" "False" "1.563" "1" "1" "1" "1" "655" "73.8" "6.62" "0.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00651, Pf01344, Pf07707" "90293" "ENSG00000003096" "KLHL13" "B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; hsa:90293; Q6P2E3; Q96QI7; Q9P2N7; Q9UDN9" "" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "2" "0" "0.936" "0.982" "0.670" "1.073" "1.167" "1.067" "0.847" "1.013" "1.341" "34.6" "32.4" "34.0" "23.2" "37.1" "40.4" "36.9" "29.3" "35.1" "46.4" "" "" "" "" "" "" "" "" "" "" "31.1" "26.2" "30.7" "22.6" "30.6" "40.4" "27.6" "25.9" "31.4" "16.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8492705118991645962" "False" "Medium" "IsMasterProtein" "P0CG35" "Thymosin beta-15B OS=Homo sapiens OX=9606 GN=TMSB15B PE=1 SV=1" "0.037" "False" "1.562" "16" "1" "2" "1" "45" "5.2" "5.36" "6.47" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf01290" "11013; 286527" "ENSG00000158427" "TMSB15B" "A8K614; hsa:11013; hsa:286527; P0CG35; Q99406" "" "" "0" "0" "1.058" "0.905" "0.877" "1.063" "1.109" "1.208" "1.021" "0.968" "0.802" "270.3" "286.1" "244.6" "237.0" "287.4" "299.9" "326.5" "275.9" "261.6" "216.7" "" "" "" "" "" "" "" "" "" "" "243.1" "231.5" "221.2" "231.3" "237.1" "299.9" "244.5" "243.7" "234.1" "77.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8829402414080751233" "False" "Medium" "IsMasterProtein" "Cont_P07589" "Fibronectin OS=Bos taurus OX=9913 GN=FN1 PE=1 SV=4" "0.037" "True" "1.560" "0" "1" "1" "1" "2478" "272.0" "5.50" "0.00" "1" "cell adhesion;cell organization and biogenesis;stress response;developmental processes;other biological processes" "non-structural extracellular" "signal transduction activity or receptor binding;other molecular function" "Pf00039, Pf00040, Pf00041" "" "" "FN1" "P07589" "" "" "0" "0" "1.180" "1.315" "1.290" "1.230" "0.879" "1.078" "1.070" "0.981" "3.672" "49.8" "58.7" "65.4" "64.2" "61.2" "43.8" "53.6" "53.2" "48.8" "182.7" "" "" "" "" "" "" "" "" "" "" "44.7" "47.5" "59.2" "62.7" "50.5" "43.8" "40.1" "47.0" "43.7" "65.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2638757817663245614" "False" "Medium" "IsMasterProtein" "Q9UK11" "Zinc finger protein 223 OS=Homo sapiens OX=9606 GN=ZNF223 PE=1 SV=2" "0.037" "False" "1.559" "2" "1" "1" "1" "482" "55.7" "8.73" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "7766" "ENSG00000178386" "ZNF223" "hsa:7766; Q15736; Q8TBJ3; Q9HCA9; Q9UK11" "" "Generic Transcription Pathway" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7418960862954659350" "False" "Medium" "IsMasterProtein" "Q8TD26" "Chromodomain-helicase-DNA-binding protein 6 OS=Homo sapiens OX=9606 GN=CHD6 PE=1 SV=4" "0.037" "False" "1.558" "1" "1" "1" "1" "2715" "305.2" "6.27" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf00385" "84181" "ENSG00000124177" "CHD6" "hsa:84181; Q5JYQ0; Q5TGZ9; Q5TH00; Q5TH01; Q8IZR2; Q8TD26; Q8WTY0; Q9H4H6; Q9H6D4; Q9NTT7; Q9P2L1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "Not Found" "Not Found" "High" "High" "High" "High" "Not Found" "Not Found" "High" "Not Found" "1" "" "-8721300767172528719" "False" "Medium" "IsMasterProtein" "O94964" "Microtubule cross-linking factor 2 OS=Homo sapiens OX=9606 GN=MTCL2 PE=1 SV=3" "0.037" "False" "1.556" "1" "1" "1" "1" "1661" "183.7" "6.52" "0.00" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "" "Pf11365, Pf14818" "140710" "ENSG00000149639" "MTCL2" "A6NK10; hsa:140710; O94964; Q14DB2; Q5JW51; Q6ZTG8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5163626551938173047" "False" "Medium" "IsMasterProtein" "P27987" "Inositol-trisphosphate 3-kinase B OS=Homo sapiens OX=9606 GN=ITPKB PE=1 SV=5" "0.037" "False" "1.554" "1" "1" "1" "1" "946" "102.3" "8.43" "2.04" "1" "cell cycle OR cell proliferation;other metabolic processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "kinase activity;other molecular function" "Pf03770" "3707" "ENSG00000143772" "ITPKB" "hsa:3707; P27987; Q5VWL9; Q5VWM0; Q96BZ2; Q96JS1; Q9UH47" "CCL18 signaling pathway" "Synthesis of IP3 and IP4 in the cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8066723703653811047" "False" "Medium" "IsMasterProtein" "P53814" "Smoothelin OS=Homo sapiens OX=9606 GN=SMTN PE=1 SV=7" "0.037" "False" "1.554" "1" "1" "1" "1" "917" "99.0" "9.07" "2.61" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00307, Pf12510" "6525" "ENSG00000183963" "SMTN" "hsa:6525; O00569; O95769; O95937; P53814; Q8N4H8; Q8WWW1; Q8WWW2; Q9P1S8; Q9UIT1; Q9UIT2" "" "" "0" "0" "0.782" "1.655" "0.958" "0.900" "1.416" "0.928" "0.960" "1.366" "1.690" "36.6" "28.7" "60.6" "35.1" "33.0" "51.9" "34.0" "35.2" "50.0" "61.9" "" "" "" "" "" "" "" "" "" "" "32.9" "23.2" "54.8" "34.3" "27.2" "51.9" "25.5" "31.1" "44.8" "22.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1016656761563188351" "False" "Medium" "IsMasterProtein" "O15127" "Secretory carrier-associated membrane protein 2 OS=Homo sapiens OX=9606 GN=SCAMP2 PE=1 SV=2" "0.037" "False" "1.553" "2" "1" "1" "1" "329" "36.6" "6.10" "2.71" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "" "Pf04144" "10066" "ENSG00000140497" "SCAMP2" "B2RDF0; hsa:10066; O15127; Q9BQE8" "Serotonin transporter activity; Monoamine transport" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6949912149279569323" "False" "Medium" "IsMasterProtein" "Q9BS16" "Centromere protein K OS=Homo sapiens OX=9606 GN=CENPK PE=1 SV=1" "0.038" "False" "1.552" "3" "1" "1" "1" "269" "31.6" "4.89" "3.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;nucleus;other cell component" "" "Pf11802" "64105" "ENSG00000123219" "CENPK" "hsa:64105; Q9BS16; Q9H4L0" "" "Separation of Sister Chromatids; Resolution of Sister Chromatid Cohesion; RHO GTPases Activate Formins; EML4 and NUDC in mitotic spindle formation; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal; Deposition of new CENPA-containing nucleosomes at the centromere" "7" "0" "1.048" "1.071" "0.983" "1.208" "1.119" "1.247" "1.132" "1.085" "1.718" "135.0" "141.6" "144.6" "132.8" "163.2" "151.1" "168.4" "152.9" "146.6" "232.1" "" "" "" "" "" "" "" "" "" "" "121.4" "114.6" "130.8" "129.6" "134.6" "151.1" "126.1" "135.0" "131.1" "82.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3776738511839178389" "False" "Medium" "IsMasterProtein" "P63316" "Troponin C, slow skeletal and cardiac muscles OS=Homo sapiens OX=9606 GN=TNNC1 PE=1 SV=1" "0.038" "False" "1.549" "7" "1" "1" "1" "161" "18.4" "4.18" "2.82" "1" "developmental processes;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf13499, Pf13833" "7134" "ENSG00000114854" "TNNC1" "hsa:7134; O14800; P02590; P04463; P63316" "MFAP5-mediated ovarian cancer cell motility and invasiveness; Striated muscle contraction pathway" "Striated Muscle Contraction" "3" "0" "0.791" "1.087" "0.527" "0.496" "0.633" "0.540" "0.621" "0.425" "0.449" "167.2" "132.2" "181.8" "88.1" "82.8" "105.8" "90.3" "103.9" "71.0" "75.0" "" "" "" "" "" "" "" "" "" "" "150.3" "107.0" "164.4" "86.0" "68.4" "105.8" "67.7" "91.7" "63.5" "26.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2614518522529293616" "False" "Medium" "IsMasterProtein" "Q32M88" "Protein-glucosylgalactosylhydroxylysine glucosidase OS=Homo sapiens OX=9606 GN=PGGHG PE=1 SV=2" "0.038" "False" "1.549" "1" "1" "1" "1" "737" "80.6" "5.25" "2.09" "1" "other metabolic processes" "cytosol" "other molecular function" "Pf03632" "80162" "ENSG00000142102" "PGGHG" "hsa:80162; Q32M88; Q658X8; Q8TEG9; Q9H635" "" "" "0" "0" "0.931" "1.105" "0.863" "1.074" "0.974" "1.086" "0.950" "1.062" "0.922" "162.7" "151.5" "179.8" "140.5" "174.8" "158.5" "176.8" "154.6" "172.9" "150.1" "" "" "" "" "" "" "" "" "" "" "146.3" "122.6" "162.7" "137.2" "144.3" "158.5" "132.4" "136.5" "154.7" "53.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7587764609471779486" "False" "Medium" "IsMasterProtein" "Q9P1V8" "Sterile alpha motif domain-containing protein 15 OS=Homo sapiens OX=9606 GN=SAMD15 PE=1 SV=1" "0.038" "False" "1.547" "1" "1" "1" "1" "674" "77.1" "4.45" "2.71" "1" "" "" "" "Pf07647" "161394" "ENSG00000100583" "SAMD15" "hsa:161394; Q2M3P3; Q9P1V8" "" "" "0" "0" "1.178" "1.086" "1.013" "1.022" "1.087" "1.157" "1.044" "1.046" "1.214" "128.4" "151.2" "139.3" "130.0" "131.2" "139.5" "148.5" "134.0" "134.3" "155.9" "" "" "" "" "" "" "" "" "" "" "115.4" "122.3" "126.0" "126.9" "108.3" "139.5" "111.2" "118.3" "120.2" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-323839447441261697" "False" "Medium" "IsMasterProtein" "Q9NWK9" "Box C/D snoRNA protein 1 OS=Homo sapiens OX=9606 GN=ZNHIT6 PE=1 SV=1" "0.038" "False" "1.545" "1" "1" "1" "1" "470" "53.9" "5.80" "2.23" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf04438" "54680" "ENSG00000117174" "ZNHIT6" "B2RBA1; B4DP13; D3DT20; hsa:54680; Q9H278; Q9H3X3; Q9NWK9; Q9NWN0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8244931832406879896" "False" "Medium" "IsMasterProtein" "P78424" "POU domain, class 6, transcription factor 2 OS=Homo sapiens OX=9606 GN=POU6F2 PE=1 SV=3" "0.038" "False" "1.545" "1" "1" "1" "1" "691" "73.2" "7.77" "2.26" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf00157" "11281" "ENSG00000106536" "POU6F2" "A4D1W2; C4AMB9; hsa:11281; P78424; P78425; Q75ME8; Q86UM6; Q9UDS7" "" "" "0" "0" "1.034" "0.982" "0.916" "1.003" "0.801" "1.100" "1.034" "0.880" "0.976" "79.9" "82.6" "78.5" "73.2" "80.1" "64.0" "87.8" "82.6" "70.3" "78.0" "" "" "" "" "" "" "" "" "" "" "71.8" "66.8" "71.0" "71.4" "66.1" "64.0" "65.8" "72.9" "62.9" "27.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7676030556128945513" "False" "Medium" "IsMasterProtein" "Q8WXX7" "Autism susceptibility gene 2 protein OS=Homo sapiens OX=9606 GN=AUTS2 PE=1 SV=1" "0.038" "False" "1.542" "1" "1" "1" "1" "1259" "138.9" "9.38" "2.36" "1" "cell organization and biogenesis;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "other molecular function" "Pf15336" "26053" "ENSG00000158321" "AUTS2" "A4D1Y9; L7QET3; L7QF75; Q5D049; Q6PJU5; Q8WXX7; Q9Y4F2" "" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3586034237824916844" "False" "Medium" "IsMasterProtein" "P11117" "Lysosomal acid phosphatase OS=Homo sapiens OX=9606 GN=ACP2 PE=1 SV=3" "0.038" "False" "1.539" "2" "1" "1" "1" "423" "48.3" "6.74" "2.67" "1" "cell organization and biogenesis;other metabolic processes" "other membranes;other cytoplasmic organelle" "other molecular function" "Pf00328" "53" "ENSG00000134575" "ACP2" "E9PCI1; hsa:53; P11117; Q561W5; Q9BTU7" "" "" "0" "0" "0.945" "0.829" "0.954" "1.451" "0.946" "2.223" "0.906" "1.004" "0.859" "91.7" "86.7" "76.1" "87.5" "133.1" "86.7" "203.9" "83.1" "92.1" "78.8" "" "" "" "" "" "" "" "" "" "" "82.5" "70.1" "68.8" "85.5" "109.8" "86.7" "152.7" "73.4" "82.4" "28.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8480986397388579687" "False" "Medium" "IsMasterProtein" "Q9UBB9" "Tuftelin-interacting protein 11 OS=Homo sapiens OX=9606 GN=TFIP11 PE=1 SV=1" "0.038" "False" "1.537" "1" "1" "1" "1" "837" "96.8" "5.67" "1.97" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "extracellular matrix;nucleus;other cell component" "nucleic acid binding activity" "Pf01585, Pf07842, Pf12457" "24144" "ENSG00000100109" "TFIP11" "hsa:24144; O95908; Q20WL0; Q5H8V8; Q9UBB9; Q9UGV7; Q9Y2Q8" "" "mRNA Splicing - Major Pathway" "1" "0" "0.926" "1.087" "1.070" "1.077" "0.909" "0.990" "1.056" "1.061" "2.455" "74.1" "68.6" "80.5" "79.3" "79.8" "67.4" "73.4" "78.2" "78.6" "181.9" "" "" "" "" "" "" "" "" "" "" "66.6" "55.5" "72.8" "77.4" "65.8" "67.4" "54.9" "69.1" "70.3" "64.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-502282286759796404" "False" "Medium" "IsMasterProtein" "O00411" "DNA-directed RNA polymerase, mitochondrial OS=Homo sapiens OX=9606 GN=POLRMT PE=1 SV=2" "0.038" "False" "1.535" "1" "1" "1" "1" "1230" "138.5" "8.98" "2.60" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "mitochondrion;other cell component" "nucleic acid binding activity;other molecular function" "Pf00940, Pf14700" "5442" "ENSG00000099821" "POLRMT" "hsa:5442; O00411; O60370" "Mitochondrial gene expression" "Mitochondrial transcription initiation; Transcriptional activation of mitochondrial biogenesis" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6084938480373239837" "False" "Medium" "IsMasterProtein" "O15525" "Transcription factor MafG OS=Homo sapiens OX=9606 GN=MAFG PE=1 SV=1" "0.038" "False" "1.531" "4" "1" "2" "1" "162" "17.8" "10.04" "3.06" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf03131" "4097" "ENSG00000197063" "MAFG" "hsa:4097; O15525" "Quercetin and Nf-kB / AP-1 induced apoptosis; Nuclear receptors meta-pathway; NRF2 pathway; Ethanol metabolism production of ROS by CYP2E1; Rubinstein-Taybi syndrome 1" "Factors involved in megakaryocyte development and platelet production; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes" "8" "0" "1.043" "1.009" "1.130" "0.881" "1.245" "1.259" "1.035" "1.261" "1.508" "45.0" "47.0" "45.4" "50.9" "39.7" "56.1" "56.7" "46.6" "56.8" "67.9" "" "" "" "" "" "" "" "" "" "" "40.5" "38.0" "41.1" "49.7" "32.7" "56.1" "42.4" "41.2" "50.8" "24.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3291492461093928575" "False" "Medium" "IsMasterProtein" "Q8NC69" "BTB/POZ domain-containing protein KCTD6 OS=Homo sapiens OX=9606 GN=KCTD6 PE=1 SV=2" "0.038" "False" "1.530" "3" "1" "1" "1" "237" "27.6" "5.96" "2.54" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf02214" "200845" "ENSG00000168301" "KCTD6" "B3KNI5; hsa:200845; Q8NBS6; Q8NC69; Q8TCA6" "" "Estrogen-dependent gene expression; Neddylation; Antigen processing: Ubiquitination & Proteasome degradation; RUNX1 regulates estrogen receptor mediated transcription" "4" "0" "1.076" "1.068" "0.937" "1.069" "1.152" "1.132" "1.018" "1.185" "0.811" "159.2" "171.4" "170.0" "149.1" "170.2" "183.4" "180.3" "162.0" "188.6" "129.0" "" "" "" "" "" "" "" "" "" "" "143.1" "138.7" "153.8" "145.6" "140.5" "183.4" "135.0" "143.1" "168.7" "46.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3631447251705766019" "False" "Medium" "IsMasterProtein" "Q96BN6" "Primary cilium assembly protein FAM149B1 OS=Homo sapiens OX=9606 GN=FAM149B1 PE=1 SV=2" "0.039" "False" "1.525" "3" "1" "1" "1" "582" "64.6" "6.77" "0.00" "1" "cell organization and biogenesis;other biological processes" "other cell component" "" "Pf12516" "317662" "ENSG00000138286" "FAM149B1" "hsa:317662; Q96BN6; Q9Y2I0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4873150472968897924" "False" "Medium" "IsMasterProtein" "Q68DE3" "Basic helix-loop-helix domain-containing protein USF3 OS=Homo sapiens OX=9606 GN=USF3 PE=1 SV=4" "0.039" "False" "1.525" "0" "1" "1" "1" "2245" "241.5" "7.61" "2.99" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00010" "205717" "ENSG00000176542" "USF3" "hsa:205717; Q68DE3; Q7Z3L9; Q8IVF3; Q9H8T4" "" "" "0" "0" "1.110" "0.945" "1.081" "1.295" "0.934" "1.091" "1.235" "1.070" "0.842" "107.3" "119.0" "101.4" "115.9" "138.9" "100.2" "117.0" "132.5" "114.8" "90.3" "" "" "" "" "" "" "" "" "" "" "96.4" "96.3" "91.7" "113.2" "114.6" "100.2" "87.6" "117.0" "102.7" "32.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6036222574917656862" "False" "Medium" "IsMasterProtein" "Q9ULQ1" "Two pore channel protein 1 OS=Homo sapiens OX=9606 GN=TPCN1 PE=1 SV=3" "0.039" "False" "1.524" "1" "1" "1" "1" "816" "94.1" "8.27" "2.98" "1" "transport;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle" "transporter activity;other molecular function" "Pf00520" "53373" "ENSG00000186815" "TPCN1" "A7E258; hsa:53373; Q86XS9; Q8NC20; Q9ULQ1" "" "Stimuli-sensing channels" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2190798800217515771" "False" "Medium" "IsMasterProtein" "Q09428" "ATP-binding cassette sub-family C member 8 OS=Homo sapiens OX=9606 GN=ABCC8 PE=1 SV=6" "0.039" "False" "1.522" "0" "1" "1" "1" "1581" "176.9" "7.81" "2.44" "1" "cell-cell signaling;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi" "transporter activity;other molecular function" "Pf00005, Pf00664" "6833" "ENSG00000006071" "ABCC8" "A6NMX8; E3UYX6; hsa:6833; O75948; Q09428; Q16583" "" "Regulation of insulin secretion; ATP sensitive Potassium channels; Defective ABCC8 can cause hypo- and hyper-glycemias" "3" "0" "0.971" "0.962" "0.925" "0.979" "0.906" "0.850" "0.956" "1.001" "0.722" "246.0" "238.8" "236.8" "227.7" "240.9" "222.9" "209.2" "235.2" "246.3" "177.5" "" "" "" "" "" "" "" "" "" "" "221.2" "193.2" "214.2" "222.2" "198.8" "222.9" "156.7" "207.7" "220.4" "63.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9006090613461540118" "False" "Medium" "IsMasterProtein" "Q6ZSS3" "Zinc finger protein 621 OS=Homo sapiens OX=9606 GN=ZNF621 PE=1 SV=1" "0.039" "False" "1.515" "2" "1" "5" "1" "439" "49.2" "8.94" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "285268" "ENSG00000172888" "ZNF621" "hsa:285268; Q14DC7; Q6ZSS3; Q8TE91" "" "Generic Transcription Pathway" "1" "0" "1.094" "1.321" "0.726" "1.030" "1.907" "2.269" "1.441" "1.318" "1.155" "9.9" "10.9" "13.1" "7.2" "10.2" "18.9" "22.5" "14.3" "13.1" "11.5" "" "" "" "" "" "" "" "" "" "" "8.9" "8.8" "11.9" "7.0" "8.4" "18.9" "16.9" "12.6" "11.7" "4.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2830044748160233517" "False" "Medium" "IsMasterProtein" "Q7RTU9" "Stereocilin OS=Homo sapiens OX=9606 GN=STRC PE=2 SV=1" "0.040" "False" "1.501" "1" "1" "1" "1" "1775" "192.8" "5.41" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "other cell component" "" "Pf21058" "161497" "ENSG00000242866" "STRC" "hsa:161497; Q7RTU9" "" "Sensory processing of sound by inner hair cells of the cochlea; Sensory processing of sound by outer hair cells of the cochlea" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-9200993166108458048" "False" "Medium" "IsMasterProtein" "P29728" "2'-5'-oligoadenylate synthase 2 OS=Homo sapiens OX=9606 GN=OAS2 PE=1 SV=3" "0.040" "False" "1.498" "2" "1" "1" "1" "719" "82.4" "8.25" "2.41" "1" "RNA metabolism OR transcription;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01909, Pf10421" "4939" "ENSG00000111335" "OAS2" "A8K9T1; hsa:4939; P29728; Q6PJ33; Q86XX8" "Non-genomic actions of 1,25 dihydroxyvitamin D3; Measles virus infection; Type I interferon induction and signaling during SARS-CoV-2 infection; Host-pathogen interaction of human coronaviruses - interferon induction" "RSV-host interactions; OAS antiviral response; Interferon gamma signaling; Interferon alpha/beta signaling" "8" "0" "3.767" "1.245" "0.889" "5.061" "5.003" "4.034" "0.921" "4.376" "2.704" "33.7" "126.9" "41.9" "29.9" "170.5" "168.5" "135.9" "31.0" "147.4" "91.1" "" "" "" "" "" "" "" "" "" "" "30.3" "102.7" "37.9" "29.2" "140.7" "168.5" "101.7" "27.4" "131.9" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1405683931259683503" "False" "Medium" "IsMasterProtein" "Q96M63" "Outer dynein arm-docking complex subunit 1 OS=Homo sapiens OX=9606 GN=ODAD1 PE=1 SV=3" "0.041" "False" "1.492" "2" "1" "1" "1" "670" "75.0" "6.28" "2.33" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "Pf21773" "93233" "ENSG00000105479" "ODAD1" "hsa:93233; Q6ZRL4; Q96M06; Q96M63; Q9UFG8" "Ciliopathies" "" "1" "0" "1.128" "1.056" "1.058" "0.945" "0.961" "1.091" "1.028" "1.117" "1.170" "77.7" "87.7" "82.1" "82.2" "73.5" "74.7" "84.8" "79.9" "86.9" "91.0" "" "" "" "" "" "" "" "" "" "" "69.9" "71.0" "74.3" "80.3" "60.6" "74.7" "63.5" "70.6" "77.7" "32.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7696548814850869284" "False" "Medium" "IsMasterProtein" "Q6ZNG0" "Zinc finger protein 620 OS=Homo sapiens OX=9606 GN=ZNF620 PE=1 SV=1" "0.041" "False" "1.488" "1" "1" "1" "1" "422" "48.5" "8.29" "2.75" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13465" "253639" "ENSG00000177842" "ZNF620" "hsa:253639; Q6ZNG0; Q8N223" "" "Generic Transcription Pathway" "1" "0" "0.973" "1.273" "0.741" "0.859" "0.773" "0.848" "0.933" "0.738" "0.789" "111.7" "108.6" "142.2" "82.8" "95.9" "86.3" "94.7" "104.2" "82.4" "88.1" "" "" "" "" "" "" "" "" "" "" "100.4" "87.9" "128.6" "80.8" "79.2" "86.3" "70.9" "92.1" "73.8" "31.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5791585126550970566" "False" "Medium" "IsMasterProtein" "Q49A88" "Coiled-coil domain-containing protein 14 OS=Homo sapiens OX=9606 GN=CCDC14 PE=1 SV=3" "0.041" "False" "1.487" "1" "1" "1" "1" "953" "106.2" "8.40" "2.96" "1" "other biological processes" "cytoskeleton;other cell component" "" "Pf15254" "64770" "ENSG00000175455" "CCDC14" "B7Z2Q3; B7Z2T2; B8ZZ41; B8ZZ58; D3DN98; hsa:64770; Q49A88; Q7Z3N3; Q86T30; Q8IWF8; Q8WUJ8; Q96K47; Q9H9A3; Q9UFH0" "" "" "0" "0" "0.843" "0.966" "1.026" "0.973" "1.054" "1.123" "0.913" "0.936" "0.502" "174.6" "147.1" "168.6" "179.1" "169.9" "184.0" "196.1" "159.3" "163.3" "87.7" "" "" "" "" "" "" "" "" "" "" "157.0" "119.0" "152.5" "174.8" "140.2" "184.0" "146.8" "140.7" "146.2" "31.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "826829819136401655" "False" "Medium" "IsMasterProtein" "Q9NRK6" "ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens OX=9606 GN=ABCB10 PE=1 SV=2" "0.041" "False" "1.487" "1" "1" "1" "1" "738" "79.1" "9.85" "2.16" "1" "other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion" "transporter activity;other molecular function" "Pf00005, Pf00664" "23456" "ENSG00000135776" "ABCB10" "hsa:23456; Q13040; Q6P1Q8; Q9H3V0; Q9NRK6" "" "Mitochondrial ABC transporters" "1" "0" "0.912" "1.137" "0.751" "0.839" "0.778" "0.780" "0.739" "0.854" "0.659" "175.6" "160.2" "199.7" "132.0" "147.4" "136.6" "137.1" "129.7" "150.0" "115.8" "" "" "" "" "" "" "" "" "" "" "157.9" "129.6" "180.6" "128.8" "121.6" "136.6" "102.6" "114.6" "134.3" "41.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8314583423527293992" "False" "Medium" "IsMasterProtein" "Q96SZ6" "Mitochondrial tRNA methylthiotransferase CDK5RAP1 OS=Homo sapiens OX=9606 GN=CDK5RAP1 PE=1 SV=2" "0.042" "False" "1.483" "2" "1" "1" "1" "601" "67.6" "8.21" "3.09" "1" "RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "cytosol;mitochondrion;nucleus" "other molecular function" "Pf00919, Pf01938, Pf04055" "51654" "ENSG00000101391" "CDK5RAP1" "A8K7R0; hsa:51654; Q5QP46; Q5QP47; Q5QP48; Q675N4; Q675N5; Q96SZ6; Q9BVG6; Q9BWZ5; Q9H859; Q9NZZ9; Q9Y3F0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5195647642425591754" "False" "Medium" "IsMasterProtein" "O43795" "Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3" "0.042" "False" "1.482" "1" "1" "2" "1" "1136" "131.9" "9.38" "4.98" "1" "cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00063, Pf00612, Pf06017" "4430" "ENSG00000128641" "MYO1B" "hsa:4430; O43794; O43795; Q7Z6L5" "" "" "0" "0" "0.755" "0.824" "0.696" "0.630" "0.757" "0.718" "0.880" "0.784" "0.767" "175.5" "132.5" "144.6" "122.2" "110.5" "132.9" "126.0" "154.5" "137.7" "134.6" "" "" "" "" "" "" "" "" "" "" "157.8" "107.2" "130.8" "119.2" "91.2" "132.9" "94.3" "136.5" "123.2" "48.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8526861795692287608" "False" "Medium" "IsMasterProtein" "Q6PK04" "Coiled-coil domain-containing protein 137 OS=Homo sapiens OX=9606 GN=CCDC137 PE=1 SV=1" "0.042" "False" "1.477" "3" "1" "1" "1" "289" "33.2" "10.93" "2.87" "1" "" "nucleus;other cell component" "" "" "339230" "ENSG00000185298" "CCDC137" "hsa:339230; Q6PK04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5444771599092088743" "False" "Medium" "IsMasterProtein" "Q96EY9" "Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Homo sapiens OX=9606 GN=ADAT3 PE=1 SV=1" "0.042" "False" "1.473" "2" "1" "1" "1" "351" "38.0" "7.88" "2.73" "1" "RNA metabolism OR transcription;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf00383" "113179" "" "ADAT3" "hsa:113179; Q96EY9" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.030" "1.033" "1.051" "1.087" "1.081" "1.133" "1.024" "0.980" "1.078" "235.9" "242.9" "243.6" "247.9" "256.5" "255.1" "267.3" "241.6" "231.2" "254.2" "" "" "" "" "" "" "" "" "" "" "212.1" "196.5" "220.4" "242.0" "211.7" "255.1" "200.2" "213.4" "206.9" "90.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4192017138878545272" "False" "Medium" "IsMasterProtein" "P08582" "Melanotransferrin OS=Homo sapiens OX=9606 GN=MELTF PE=1 SV=2" "0.042" "False" "1.470" "1" "1" "1" "1" "738" "80.2" "5.94" "2.03" "1" "transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00405" "4241" "ENSG00000163975" "MELTF" "hsa:4241; P08582; Q9BQE2" "3q29 copy number variation syndrome" "Post-translational modification: synthesis of GPI-anchored proteins; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs); Post-translational protein phosphorylation" "4" "0" "1.347" "0.675" "1.131" "0.884" "1.095" "1.105" "0.969" "0.952" "0.809" "27.4" "36.9" "18.5" "31.0" "24.2" "30.0" "30.3" "26.6" "26.1" "22.1" "" "" "" "" "" "" "" "" "" "" "24.6" "29.9" "16.7" "30.2" "20.0" "30.0" "22.7" "23.5" "23.3" "7.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5221985020490519737" "False" "Medium" "IsMasterProtein" "Q6PJI9" "GATOR2 complex protein WDR59 OS=Homo sapiens OX=9606 GN=WDR59 PE=1 SV=2" "0.042" "False" "1.465" "1" "1" "1" "1" "974" "109.7" "7.91" "3.24" "1" "stress response;other biological processes" "other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00400, Pf17120" "79726" "ENSG00000103091" "WDR59" "B3KRC3; hsa:79726; Q6PJI9; Q71RE7; Q96PW5; Q9BSW6; Q9HA43" "" "Amino acids regulate mTORC1" "1" "0" "0.977" "0.967" "0.823" "0.877" "1.081" "0.911" "0.903" "0.886" "1.057" "84.2" "82.2" "81.4" "69.3" "73.8" "91.0" "76.7" "76.0" "74.6" "89.0" "" "" "" "" "" "" "" "" "" "" "75.7" "66.5" "73.7" "67.7" "60.9" "91.0" "57.4" "67.2" "66.7" "31.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3116404034014267296" "False" "Medium" "IsMasterProtein" "Q5U5Q3" "RNA-binding E3 ubiquitin-protein ligase MEX3C OS=Homo sapiens OX=9606 GN=MEX3C PE=1 SV=3" "0.043" "False" "1.456" "1" "1" "1" "1" "659" "69.3" "5.00" "3.84" "1" "developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00013, Pf13920" "51320" "ENSG00000176624" "MEX3C" "A1L022; Q5U5Q3; Q9NZE3" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.945" "0.908" "0.838" "0.910" "0.897" "0.872" "1.080" "0.854" "1.350" "141.8" "134.0" "128.7" "118.7" "128.9" "127.2" "123.6" "153.2" "121.0" "191.4" "" "" "" "" "" "" "" "" "" "" "127.5" "108.5" "116.4" "115.9" "106.4" "127.2" "92.6" "135.3" "108.3" "68.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5445945494011334825" "False" "Medium" "IsMasterProtein" "Q5SWL7" "PRAME family member 14 OS=Homo sapiens OX=9606 GN=PRAMEF14 PE=3 SV=2" "0.043" "False" "1.454" "3" "1" "1" "1" "474" "55.0" "8.38" "0.00" "1" "other biological processes" "other cell component" "" "" "729528" "ENSG00000204481" "PRAMEF14" "A6NFR9; hsa:729528; Q5SWL7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5316556995515416405" "False" "Medium" "IsMasterProtein" "Q6R327" "Rapamycin-insensitive companion of mTOR OS=Homo sapiens OX=9606 GN=RICTOR PE=1 SV=1" "0.043" "False" "1.454" "0" "1" "1" "1" "1708" "192.1" "7.47" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;signal transduction;other biological processes" "cytosol;ER/Golgi;other cell component" "enzyme regulator activity;translation activity;other molecular function" "Pf14663, Pf14664, Pf14665, Pf14666, Pf14668" "253260" "ENSG00000164327" "RICTOR" "B2RNX0; B7ZMF7; hsa:253260; Q68DT5; Q6R327; Q86UB7; Q8N3A0; Q8NCM6" "Target of rapamycin signaling; Androgen receptor network in prostate cancer; Oncostatin M signaling pathway; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling; VEGFA-VEGFR2 signaling; Angiopoietin-like protein 8 regulatory pathway; EGF/EGFR signaling pathway; Head and neck squamous cell carcinoma; ADHD and autism (ASD) linked metabolic pathways and SNP" "Constitutive Signaling by AKT1 E17K in Cancer; PIP3 activates AKT signaling; Regulation of TP53 Degradation; CD28 dependent PI3K/Akt signaling; VEGFR2 mediated vascular permeability" "15" "0" "0.741" "0.955" "0.871" "0.883" "0.865" "0.891" "0.915" "0.786" "0.698" "53.8" "39.8" "51.3" "46.8" "47.5" "46.5" "47.9" "49.2" "42.2" "37.5" "" "" "" "" "" "" "" "" "" "" "48.3" "32.2" "46.4" "45.7" "39.2" "46.5" "35.8" "43.4" "37.8" "13.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4379760637260408302" "False" "Medium" "IsMasterProtein" "Q9NS69" "Mitochondrial import receptor subunit TOM22 homolog OS=Homo sapiens OX=9606 GN=TOMM22 PE=1 SV=3" "0.043" "False" "1.453" "11" "1" "1" "1" "142" "15.5" "4.34" "2.68" "1" "cell organization and biogenesis;transport;other biological processes" "other membranes;mitochondrion" "transporter activity" "Pf04281" "56993" "ENSG00000100216" "TOMM22" "hsa:56993; Q9NS69" "" "Mitochondrial protein import; PINK1-PRKN Mediated Mitophagy" "2" "0" "1.188" "0.926" "0.967" "1.093" "0.828" "1.186" "1.028" "1.140" "0.803" "44.1" "52.4" "40.9" "42.6" "48.2" "36.5" "52.3" "45.4" "50.3" "35.4" "" "" "" "" "" "" "" "" "" "" "39.7" "42.4" "37.0" "41.6" "39.8" "36.5" "39.2" "40.1" "45.0" "12.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1851911761268984934" "False" "Medium" "IsMasterProtein" "O00418" "Eukaryotic elongation factor 2 kinase OS=Homo sapiens OX=9606 GN=EEF2K PE=1 SV=2" "0.043" "False" "1.452" "1" "1" "1" "1" "725" "82.1" "5.33" "3.19" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;other biological processes" "cytosol;other cell component" "nucleic acid binding activity;kinase activity;other molecular function" "Pf02816" "29904" "ENSG00000103319" "EEF2K" "hsa:29904; O00418; Q8N588" "Translation factors; AMP-activated protein kinase signaling; BDNF-TrkB signaling" "mTORC1-mediated signalling" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1500672588244887756" "False" "Medium" "IsMasterProtein" "P05089" "Arginase-1 OS=Homo sapiens OX=9606 GN=ARG1 PE=1 SV=2" "0.043" "False" "1.451" "3" "1" "1" "1" "322" "34.7" "7.21" "4.08" "1" "other metabolic processes;stress response;other biological processes" "non-structural extracellular;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf00491" "383" "ENSG00000118520" "ARG1" "A6NEA0; hsa:383; P05089; Q5JWT5; Q5JWT6; Q8TE72; Q9BS50" "Spinal cord injury; Amino acid metabolism; IL-18 signaling pathway" "Neutrophil degranulation; Urea cycle" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2770805407930148158" "False" "Medium" "IsMasterProtein" "Q9HBG7" "T-lymphocyte surface antigen Ly-9 OS=Homo sapiens OX=9606 GN=LY9 PE=1 SV=3" "0.043" "False" "1.450" "1" "1" "1" "1" "655" "72.1" "5.52" "2.77" "1" "cell adhesion;stress response;other biological processes" "plasma membrane;other membranes" "" "" "4063" "ENSG00000122224" "LY9" "A8K7N3; hsa:4063; Q14775; Q5VYI3; Q6P2J4; Q9H4N5; Q9HBG7; Q9NQ24" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5200285318932313306" "False" "Medium" "IsMasterProtein" "Q9UHR6" "Zinc finger HIT domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ZNHIT2 PE=1 SV=1" "0.043" "False" "1.449" "3" "1" "1" "1" "403" "42.9" "5.99" "1.85" "1" "" "" "other molecular function" "Pf04438" "741" "ENSG00000174276" "ZNHIT2" "hsa:741; Q3SY14; Q8IUV0; Q9UHR6" "" "" "0" "0" "1.476" "1.222" "0.878" "1.623" "1.342" "1.387" "0.882" "0.992" "5.056" "12.2" "18.0" "14.9" "10.7" "19.8" "16.3" "16.9" "10.7" "12.1" "61.5" "" "" "" "" "" "" "" "" "" "" "10.9" "14.5" "13.5" "10.4" "16.3" "16.3" "12.6" "9.5" "10.8" "22.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2802895978922525693" "False" "Medium" "IsMasterProtein" "O15151" "Protein Mdm4 OS=Homo sapiens OX=9606 GN=MDM4 PE=1 SV=2" "0.045" "False" "1.442" "3" "1" "1" "1" "490" "54.8" "5.00" "2.08" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00641, Pf13920" "4194" "ENSG00000198625" "MDM4" "hsa:4194; O15151; Q2M2Y2; Q32SL2; Q6GS18; Q8IV83" "Glioblastoma signaling pathways; Pleural mesothelioma" "Ub-specific processing proteases; Regulation of TP53 Degradation; Oxidative Stress Induced Senescence; Regulation of TP53 Activity through Phosphorylation; Oncogene Induced Senescence; Regulation of TP53 Activity through Methylation; Stabilization of p53" "9" "0" "3.077" "1.142" "1.107" "4.191" "3.702" "2.799" "1.097" "3.827" "2.597" "47.0" "144.7" "53.7" "52.1" "197.1" "174.1" "131.7" "51.6" "180.0" "122.1" "" "" "" "" "" "" "" "" "" "" "42.3" "117.1" "48.6" "50.9" "162.7" "174.1" "98.6" "45.6" "161.1" "43.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4052352701498406510" "False" "Medium" "IsMasterProtein" "Q9Y6J9" "TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens OX=9606 GN=TAF6L PE=1 SV=1" "0.045" "False" "1.440" "1" "1" "1" "1" "622" "67.8" "8.97" "1.63" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02969, Pf07571" "10629" "ENSG00000162227" "TAF6L" "B2RAT0; hsa:10629; Q96HA6; Q9Y6J9" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-345522786131708725" "False" "Medium" "IsMasterProtein" "Q14571" "Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 OS=Homo sapiens OX=9606 GN=ITPR2 PE=1 SV=2" "0.045" "False" "1.440" "0" "1" "1" "1" "2701" "307.9" "6.43" "2.00" "1" "stress response;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf00520, Pf01365, Pf02815, Pf08454, Pf08709" "3709" "ENSG00000123104" "ITPR2" "hsa:3709; O94773; Q14571" "Alzheimer's disease and miRNA effects; Myometrial relaxation and contraction pathways; Vitamin D-sensitive calcium signaling in depression; Thyroid hormones production and peripheral downstream signaling effects; Alzheimer's disease; GDNF signaling; Calcium regulation in cardiac cells" "Role of phospholipids in phagocytosis; FCERI mediated Ca+2 mobilization; FCGR3A-mediated IL10 synthesis; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers; Ion homeostasis; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Ca2+ pathway; VEGFR2 mediated cell proliferation; Elevation of cytosolic Ca2+ levels; PLC beta mediated events; DAG and IP3 signaling; CLEC7A (Dectin-1) induces NFAT activation; Effects of PIP2 hydrolysis" "21" "0" "1.052" "1.039" "0.845" "1.122" "0.859" "0.769" "0.861" "0.805" "0.374" "40.8" "42.9" "42.4" "34.5" "45.8" "35.1" "31.4" "35.2" "32.9" "15.3" "" "" "" "" "" "" "" "" "" "" "36.7" "34.7" "38.4" "33.7" "37.8" "35.1" "23.5" "31.1" "29.4" "5.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5052924421224756145" "False" "Medium" "IsMasterProtein" "Q8IUZ0" "Leucine-rich repeat-containing protein 49 OS=Homo sapiens OX=9606 GN=LRRC49 PE=1 SV=2" "0.045" "False" "1.439" "1" "1" "1" "1" "686" "78.8" "7.87" "2.57" "1" "" "cytoskeleton;other cell component" "" "Pf12799, Pf14580" "54839" "ENSG00000137821" "LRRC49" "B3KVX1; B7Z366; F5H1J4; G5E9T5; H0YLN4; hsa:54839; Q8IUZ0; Q9NXM6" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7723203762439641288" "False" "Medium" "IsMasterProtein" "Q9Y5N5" "Methyltransferase N6AMT1 OS=Homo sapiens OX=9606 GN=N6AMT1 PE=1 SV=4" "0.046" "False" "1.437" "4" "1" "1" "1" "214" "22.9" "5.11" "2.52" "1" "cell organization and biogenesis;protein metabolism;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf05175" "29104" "ENSG00000156239" "N6AMT1" "B2RA97; hsa:29104; Q96F73; Q9Y5N5" "" "Eukaryotic Translation Termination; Methylation" "2" "0" "0.997" "1.142" "0.850" "1.073" "0.862" "0.758" "0.754" "0.923" "0.906" "42.5" "42.4" "48.6" "36.1" "45.7" "36.7" "32.3" "32.1" "39.3" "38.5" "" "" "" "" "" "" "" "" "" "" "38.3" "34.3" "44.0" "35.3" "37.7" "36.7" "24.2" "28.3" "35.1" "13.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3691559701632170011" "False" "Medium" "IsMasterProtein" "Q5TZ20" "Olfactory receptor 2G6 OS=Homo sapiens OX=9606 GN=OR2G6 PE=1 SV=1" "0.046" "False" "1.434" "3" "1" "1" "1" "316" "34.9" "8.50" "2.70" "1" "signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf13853" "391211" "ENSG00000188558; ENSG00000292302" "OR2G6" "B2RP33; hsa:391211; Q5TZ20" "" "Expression and translocation of olfactory receptors" "1" "0" "1.229" "1.177" "1.006" "1.161" "1.069" "1.068" "1.074" "0.979" "1.082" "87.9" "108.1" "103.5" "88.5" "102.1" "94.0" "93.9" "94.4" "86.1" "95.1" "" "" "" "" "" "" "" "" "" "" "79.1" "87.5" "93.6" "86.4" "84.2" "94.0" "70.3" "83.4" "77.0" "34.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3559893466829289199" "False" "Medium" "IsMasterProtein" "Q02641" "Voltage-dependent L-type calcium channel subunit beta-1 OS=Homo sapiens OX=9606 GN=CACNB1 PE=1 SV=3" "0.046" "False" "1.432" "2" "1" "1" "1" "598" "65.7" "6.77" "2.41" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00625, Pf12052" "782" "ENSG00000067191" "CACNB1" "A8K114; O15331; Q02639; Q02640; Q02641; Q8N3X9; Q9C085; Q9UD79" "Arrhythmogenic right ventricular cardiomyopathy; MAPK signaling pathway; 17q12 copy number variation syndrome; Affected pathways in Duchenne muscular dystrophy; Calcium regulation in cardiac cells" "NCAM1 interactions; Presynaptic depolarization and calcium channel opening; Phase 0 - rapid depolarisation; Phase 2 - plateau phase" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6606403320182529666" "False" "Medium" "IsMasterProtein" "A0AVI2" "Fer-1-like protein 5 OS=Homo sapiens OX=9606 GN=FER1L5 PE=1 SV=3" "0.047" "False" "1.419" "0" "1" "1" "1" "2057" "237.8" "8.05" "2.71" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi" "other molecular function" "Pf00168, Pf08150, Pf08165, Pf16165" "90342" "ENSG00000249715" "FER1L5" "A0A096LNV2; A0AVI2; hsa:90342; Q17RH2; Q6ZU24" "2q11.2 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2298724030714644089" "False" "Medium" "IsMasterProtein" "O43674" "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Homo sapiens OX=9606 GN=NDUFB5 PE=1 SV=1" "0.047" "False" "1.415" "4" "1" "1" "1" "189" "21.7" "9.63" "2.55" "1" "cell organization and biogenesis;other metabolic processes;transport" "other membranes;mitochondrion;nucleus" "transporter activity" "Pf09781" "4711" "ENSG00000136521" "NDUFB5" "hsa:4711; O43674; Q561V6" "Electron transport chain: OXPHOS system in mitochondria; Nonalcoholic fatty liver disease; Oxidative phosphorylation" "Complex I biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4234715888592580020" "False" "Medium" "IsMasterProtein" "O75346" "Zinc finger protein 253 OS=Homo sapiens OX=9606 GN=ZNF253 PE=1 SV=2" "0.047" "False" "1.414" "1" "1" "1" "1" "499" "57.6" "9.16" "1.87" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "56242" "ENSG00000256771" "ZNF253" "A4FVA7; hsa:56242; O75346; Q0P6G3; Q6P0L2; Q8NCA3; Q8NCF9" "" "Generic Transcription Pathway" "1" "0" "0.746" "1.104" "0.947" "0.995" "0.879" "0.869" "0.837" "1.021" "0.754" "54.7" "40.8" "60.4" "51.8" "54.4" "48.1" "47.5" "45.8" "55.9" "41.3" "" "" "" "" "" "" "" "" "" "" "49.2" "33.1" "54.6" "50.6" "44.9" "48.1" "35.6" "40.5" "50.0" "14.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7581896463347869100" "False" "Medium" "IsMasterProtein" "Q8IVF4" "Dynein axonemal heavy chain 10 OS=Homo sapiens OX=9606 GN=DNAH10 PE=1 SV=4" "0.047" "False" "1.412" "0" "1" "1" "1" "4471" "514.5" "5.88" "2.32" "1" "other biological processes" "cytoskeleton" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "196385" "ENSG00000197653" "DNAH10" "C9JMF5; hsa:196385; O95495; Q6ZUC9; Q6ZUP6; Q8IVF4; Q8N761" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7550223946587707614" "False" "Medium" "IsMasterProtein" "Q13232" "Nucleoside diphosphate kinase 3 OS=Homo sapiens OX=9606 GN=NME3 PE=1 SV=2" "0.047" "False" "1.410" "4" "1" "1" "1" "169" "19.0" "7.84" "2.01" "1" "other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion" "kinase activity;other molecular function" "Pf00334" "4832" "ENSG00000103024" "NME3" "hsa:4832; Q13232; Q9BWH4" "Pyrimidine metabolism" "Interconversion of nucleotide di- and triphosphates" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7996224520520444905" "False" "Medium" "IsMasterProtein" "P09914" "Interferon-induced protein with tetratricopeptide repeats 1 OS=Homo sapiens OX=9606 GN=IFIT1 PE=1 SV=2" "0.047" "False" "1.409" "3" "1" "1" "1" "478" "55.3" "7.20" "0.00" "1" "stress response;transport;other biological processes" "cytosol;other cell component" "nucleic acid binding activity" "Pf13181, Pf13424, Pf14559" "3434" "ENSG00000185745" "IFIT1" "B3KS50; D3DR31; hsa:3434; P09914; Q5T7J1; Q96QM5" "Immune response to tuberculosis; 1p36 copy number variation syndrome" "ISG15 antiviral mechanism; Interferon alpha/beta signaling" "4" "0" "0.921" "0.939" "1.237" "1.208" "1.357" "1.427" "1.358" "1.114" "1.105" "37.1" "34.2" "34.8" "45.9" "44.8" "50.3" "52.9" "50.4" "41.3" "41.0" "" "" "" "" "" "" "" "" "" "" "33.4" "27.7" "31.5" "44.8" "37.0" "50.3" "39.6" "44.5" "37.0" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2977729941869003476" "False" "Medium" "IsMasterProtein" "Q6P4F7" "Rho GTPase-activating protein 11A OS=Homo sapiens OX=9606 GN=ARHGAP11A PE=1 SV=2" "0.048" "False" "1.408" "1" "1" "1" "1" "1023" "113.8" "9.07" "2.23" "1" "signal transduction;other biological processes" "cytosol;nucleus" "enzyme regulator activity" "Pf00620" "9824" "ENSG00000198826; ENSG00000275568" "ARHGAP11A" "B4DZN9; hsa:9824; Q6P4F7; Q6PI96; Q9Y3S6" "" "RHOA GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "211355582508718338" "False" "Medium" "IsMasterProtein" "Cont_Q03247" "Apolipoprotein E OS=Bos taurus OX=9913 GN=APOE PE=1 SV=1" "0.048" "True" "1.407" "2" "1" "1" "1" "316" "36.0" "5.67" "3.03" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "non-structural extracellular;extracellular matrix;other cytoplasmic organelle" "signal transduction activity or receptor binding;other molecular function" "Pf01442" "281004" "" "APOE" "bta:281004; Q03247; Q3T006; Q5E967" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3081851764267628818" "False" "Medium" "IsMasterProtein" "Q9Y2P8" "RNA 3'-terminal phosphate cyclase-like protein OS=Homo sapiens OX=9606 GN=RCL1 PE=1 SV=3" "0.048" "False" "1.407" "2" "1" "1" "1" "373" "40.8" "9.26" "1.64" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf01137, Pf05189" "10171" "ENSG00000120158" "RCL1" "D3DRI2; hsa:10171; Q5VYW9; Q5VZU1; Q9H9D0; Q9NY00; Q9P044; Q9Y2P8" "" "Major pathway of rRNA processing in the nucleolus and cytosol; rRNA modification in the nucleus and cytosol" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5697470728296879820" "False" "Medium" "IsMasterProtein" "Q9NNX9" "Variable charge X-linked protein 3 OS=Homo sapiens OX=9606 GN=VCX3A PE=2 SV=1" "0.048" "False" "1.400" "4" "1" "1" "1" "186" "20.0" "4.49" "1.80" "1" "developmental processes" "nucleus" "" "Pf15231" "51481" "ENSG00000169059" "VCX3A" "hsa:51481; Q9NNX9; Q9P0H4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-684970281821863116" "False" "Medium" "IsMasterProtein" "Q9BXW9" "Fanconi anemia group D2 protein OS=Homo sapiens OX=9606 GN=FANCD2 PE=1 SV=2" "0.048" "False" "1.400" "1" "1" "1" "1" "1451" "164.0" "5.88" "1.98" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf14631" "2177" "ENSG00000144554" "FANCD2" "hsa:2177; Q2LA86; Q69YP9; Q6PJN7; Q9BQ06; Q9BXW9; Q9H9T9" "miRNA regulation of DNA damage response; 15q13.3 copy number variation syndrome; DNA repair pathways, full network; 15q11q13 copy number variation; DNA damage response" "Fanconi Anemia Pathway; TP53 Regulates Transcription of DNA Repair Genes" "7" "0" "1.077" "0.703" "0.867" "0.879" "0.813" "0.831" "0.631" "0.665" "11.484" "35.4" "38.1" "24.9" "30.7" "31.1" "28.8" "29.4" "22.3" "23.5" "406.1" "" "" "" "" "" "" "" "" "" "" "31.8" "30.8" "22.5" "29.9" "25.7" "28.8" "22.0" "19.7" "21.0" "145.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5237956614587983766" "False" "Medium" "IsMasterProtein" "A6NG13" "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D OS=Homo sapiens OX=9606 GN=MGAT4D PE=2 SV=3" "0.049" "False" "1.399" "3" "1" "1" "1" "374" "43.7" "9.60" "2.52" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf04666" "152586" "ENSG00000205301" "MGAT4D" "A6NG13; hsa:152586" "N-glycan biosynthesis" "" "1" "0" "0.969" "1.039" "0.716" "0.910" "0.966" "0.796" "0.910" "0.771" "0.669" "152.0" "147.3" "157.9" "108.9" "138.3" "146.8" "121.0" "138.3" "117.2" "101.7" "" "" "" "" "" "" "" "" "" "" "136.7" "119.2" "142.8" "106.3" "114.2" "146.8" "90.6" "122.2" "104.8" "36.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1791132844314588076" "False" "Medium" "IsMasterProtein" "O43306" "Adenylate cyclase type 6 OS=Homo sapiens OX=9606 GN=ADCY6 PE=1 SV=2" "0.050" "False" "1.389" "1" "1" "1" "1" "1168" "130.5" "8.22" "2.81" "1" "other metabolic processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00211, Pf06327, Pf16214" "112" "ENSG00000174233" "ADCY6" "hsa:112; O43306; Q9NR75; Q9UDB0" "Myometrial relaxation and contraction pathways; G protein signaling pathways; Chemokine signaling pathway; Phosphodiesterases in neuronal function; Thermogenesis; Envelope proteins and their potential roles in EDMD physiopathology; Ciliopathies; Vasopressin-regulated water reabsorption; Calcium regulation in cardiac cells" "FCGR3A-mediated IL10 synthesis; G alpha (i) signalling events; G alpha (z) signalling events; Adenylate cyclase inhibitory pathway; G alpha (s) signalling events; GPER1 signaling; ADORA2B mediated anti-inflammatory cytokines production; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion; Adrenaline,noradrenaline inhibits insulin secretion; Vasopressin regulates renal water homeostasis via Aquaporins; PKA activation; PKA activation in glucagon signalling; Adenylate cyclase activating pathway; Hedgehog 'off' state" "24" "0" "1.030" "0.945" "0.975" "1.158" "1.223" "1.048" "1.072" "0.997" "1.134" "50.4" "51.9" "47.6" "49.2" "58.4" "61.7" "52.9" "54.0" "50.3" "57.2" "" "" "" "" "" "" "" "" "" "" "45.3" "42.0" "43.1" "48.0" "48.2" "61.7" "39.6" "47.7" "45.0" "20.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8520642672275204077" "False" "Low" "IsMasterProtein" "Q86YL5" "Testis development-related protein OS=Homo sapiens OX=9606 GN=TDRP PE=1 SV=2" "0.050" "False" "1.381" "8" "1" "1" "1" "185" "20.4" "6.01" "0.00" "1" "other biological processes" "cytosol;nucleus;other cell component" "" "Pf15683" "157695" "ENSG00000180190" "TDRP" "B6VF03; B9EG53; hsa:157695; Q86YL5" "" "" "0" "0" "0.794" "0.690" "0.937" "0.822" "0.645" "0.828" "0.956" "0.744" "0.787" "23.2" "18.4" "16.0" "21.7" "19.0" "14.9" "19.2" "22.2" "17.2" "18.2" "" "" "" "" "" "" "" "" "" "" "20.8" "14.9" "14.5" "21.2" "15.7" "14.9" "14.4" "19.6" "15.4" "6.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3518399781667657001" "False" "Low" "IsMasterProtein" "Q5JT25" "Ras-related protein Rab-41 OS=Homo sapiens OX=9606 GN=RAB41 PE=1 SV=2" "0.050" "False" "1.380" "5" "1" "1" "1" "222" "25.0" "5.22" "2.84" "1" "transport" "plasma membrane;other membranes;cytosol;ER/Golgi;other cell component" "other molecular function" "Pf00071" "347517" "ENSG00000147127" "RAB41" "hsa:347517; Q17RQ0; Q5JT25" "" "RAB geranylgeranylation; Intra-Golgi traffic" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4027140146514245256" "False" "Low" "IsMasterProtein" "Q9P291" "Armadillo repeat-containing X-linked protein 1 OS=Homo sapiens OX=9606 GN=ARMCX1 PE=1 SV=1" "0.050" "False" "1.374" "2" "1" "1" "1" "453" "49.2" "9.22" "2.94" "1" "other biological processes" "other membranes;mitochondrion" "" "Pf04826" "51309" "ENSG00000126947" "ARMCX1" "hsa:51309; Q53HK2; Q9H2Q0; Q9P291" "VEGFA-VEGFR2 signaling" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2292330841191308535" "False" "Low" "IsMasterProtein" "O75420" "GRB10-interacting GYF protein 1 OS=Homo sapiens OX=9606 GN=GIGYF1 PE=1 SV=2" "0.051" "False" "1.364" "1" "1" "1" "1" "1035" "114.5" "5.39" "2.15" "1" "signal transduction" "cytosol;other cell component" "" "Pf02213" "" "ENSG00000146830" "GIGYF1" "O75420; Q6Y7W7; Q8WZ38" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7158011358332950580" "False" "Low" "IsMasterProtein" "Q13394" "Putative nucleotidyltransferase MAB21L1 OS=Homo sapiens OX=9606 GN=MAB21L1 PE=1 SV=1" "0.052" "False" "1.357" "2" "1" "1" "1" "359" "40.9" "8.66" "2.69" "1" "cell cycle OR cell proliferation;developmental processes;other biological processes" "nucleus" "other molecular function" "Pf03281, Pf20266" "4081" "ENSG00000180660" "MAB21L1" "hsa:4081; Q13394; Q6I9T5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6383247100679150488" "False" "Low" "IsMasterProtein" "Q8TCC7" "Organic anion transporter 3 OS=Homo sapiens OX=9606 GN=SLC22A8 PE=1 SV=1" "0.052" "False" "1.357" "1" "1" "1" "1" "542" "59.8" "8.85" "2.05" "1" "transport;other biological processes" "plasma membrane;other membranes" "transporter activity" "Pf00083" "9376" "ENSG00000149452" "SLC22A8" "B4DPH7; F5GWA8; F5H5J1; hsa:9376; O95820; Q59EW9; Q8TCC7; Q96TC1" "Proximal tubule transport" "Ciprofloxacin ADME; Organic anion transport" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6779818437805279964" "False" "Low" "IsMasterProtein" "Q6ZRC1" "Uncharacterized protein C4orf50 OS=Homo sapiens OX=9606 GN=C4orf50 PE=2 SV=2" "0.052" "False" "1.353" "1" "1" "1" "1" "1508" "167.0" "5.72" "0.00" "1" "" "" "" "Pf15030" "" "ENSG00000181215" "C4orf50" "E9PNW5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5282175615712698371" "False" "Low" "IsMasterProtein" "Q96PQ0" "VPS10 domain-containing receptor SorCS2 OS=Homo sapiens OX=9606 GN=SORCS2 PE=1 SV=3" "0.052" "False" "1.353" "1" "1" "1" "1" "1159" "128.1" "7.08" "1.72" "1" "transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;other cytoplasmic organelle;other cell component" "other molecular function" "Pf15901, Pf15902, Pf18911" "57537" "ENSG00000184985" "SORCS2" "hsa:57537; Q96PQ0; Q9P2L7" "" "" "0" "0" "1.030" "1.105" "0.977" "1.086" "0.970" "1.054" "0.942" "0.999" "0.962" "116.1" "119.5" "128.3" "113.3" "126.0" "112.6" "122.4" "109.3" "115.9" "111.7" "" "" "" "" "" "" "" "" "" "" "104.3" "96.7" "116.0" "110.6" "104.0" "112.6" "91.6" "96.6" "103.7" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8236221211777118383" "False" "Low" "IsMasterProtein" "Q56UN5" "Mitogen-activated protein kinase kinase kinase 19 OS=Homo sapiens OX=9606 GN=MAP3K19 PE=2 SV=1" "0.052" "False" "1.351" "1" "1" "1" "1" "1328" "150.4" "7.05" "0.00" "1" "other metabolic processes" "" "kinase activity;other molecular function" "Pf00069" "80122" "ENSG00000176601" "MAP3K19" "B2RP57; B7ZMH9; E2QRE3; hsa:80122; Q56UN1; Q56UN2; Q56UN3; Q56UN4; Q56UN5; Q8N4E9; Q9H5T2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2071864531841837992" "False" "Low" "IsMasterProtein" "Q07912" "Activated CDC42 kinase 1 OS=Homo sapiens OX=9606 GN=TNK2 PE=1 SV=3" "0.053" "False" "1.347" "1" "1" "1" "1" "1038" "114.5" "7.25" "2.47" "1" "other metabolic processes;transport;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cytoplasmic organelle;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;kinase activity;other molecular function" "Pf07714, Pf09027, Pf11555, Pf14604" "10188" "ENSG00000061938" "TNK2" "hsa:10188; Q07912; Q6ZMQ0; Q8N6U7; Q96H59" "Focal adhesion; Oxidative damage response; EGF/EGFR signaling pathway; G13 signaling pathway" "" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-658722355380059482" "False" "Low" "IsMasterProtein" "Q9UPN4" "Centrosomal protein of 131 kDa OS=Homo sapiens OX=9606 GN=CEP131 PE=1 SV=3" "0.053" "False" "1.343" "1" "1" "1" "1" "1083" "122.1" "8.69" "2.72" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;transport;other biological processes" "other membranes;cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22994" "ENSG00000141577" "CEP131" "A6NHI8; B2RN11; hsa:22994; Q96F50; Q9UPN4" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.040" "1.117" "0.965" "1.093" "1.054" "1.128" "1.048" "1.002" "1.143" "153.5" "159.7" "171.6" "148.1" "167.8" "161.9" "173.2" "161.0" "153.8" "175.5" "" "" "" "" "" "" "" "" "" "" "138.0" "129.3" "155.2" "144.6" "138.5" "161.9" "129.7" "142.2" "137.6" "62.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1706023425185194062" "False" "Low" "IsMasterProtein" "Q9UBY9" "Heat shock protein beta-7 OS=Homo sapiens OX=9606 GN=HSPB7 PE=1 SV=1" "0.053" "False" "1.342" "8" "1" "1" "1" "170" "18.6" "6.52" "0.00" "1" "stress response;developmental processes;other biological processes" "cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00011" "27129" "ENSG00000173641" "HSPB7" "B3KQ37; C9K0Y0; hsa:27129; Q9NU17; Q9UBY9" "Differentiation of white and brown adipocyte" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2779381262289932464" "False" "Low" "IsMasterProtein" "P17655" "Calpain-2 catalytic subunit OS=Homo sapiens OX=9606 GN=CAPN2 PE=1 SV=6" "0.054" "False" "1.337" "2" "1" "1" "1" "700" "79.9" "4.98" "0.00" "1" "protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00648, Pf01067, Pf13833" "824" "ENSG00000162909" "CAPN2" "A6NDG7; B7ZA96; E7ES58; hsa:824; P17655; Q16738; Q6PJT3; Q8WU26; Q9HBB1" "Integrin-mediated cell adhesion; Alzheimer's disease and miRNA effects; Focal adhesion; VEGFA-VEGFR2 signaling; Alzheimer's disease; Calcium mediated T-cell apoptosis involved in inclusion body myositis" "Degradation of the extracellular matrix; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2219235455752224995" "False" "Low" "IsMasterProtein" "P29558" "RNA-binding motif, single-stranded-interacting protein 1 OS=Homo sapiens OX=9606 GN=RBMS1 PE=1 SV=3" "0.054" "False" "1.332" "4" "1" "1" "1" "406" "44.5" "8.79" "2.30" "1" "DNA metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity" "Pf00076" "5937" "ENSG00000153250" "RBMS1" "hsa:5937; P29558; Q14869; Q15433; Q53P46; Q53QX8; Q53RG6; Q8WV20" "" "" "0" "0" "1.038" "1.167" "0.902" "1.170" "0.985" "1.121" "0.912" "1.143" "1.106" "51.9" "53.9" "60.5" "46.8" "60.7" "51.1" "58.2" "47.3" "59.3" "57.4" "" "" "" "" "" "" "" "" "" "" "46.6" "43.6" "54.8" "45.7" "50.1" "51.1" "43.6" "41.8" "53.0" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4801212226395632379" "False" "Low" "IsMasterProtein" "Q9NUR3" "Transmembrane protein 74B OS=Homo sapiens OX=9606 GN=TMEM74B PE=1 SV=1" "0.054" "False" "1.330" "6" "1" "1" "1" "256" "27.5" "7.46" "0.00" "1" "" "other membranes" "" "" "55321" "ENSG00000125895" "TMEM74B" "D3DVW5; hsa:55321; Q9NUR3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "770435106078713662" "False" "Low" "IsMasterProtein" "Q8NFT6" "Protein DBF4 homolog B OS=Homo sapiens OX=9606 GN=DBF4B PE=1 SV=1" "0.054" "False" "1.328" "1" "1" "1" "1" "615" "67.2" "8.34" "2.92" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf07535" "80174" "ENSG00000161692" "DBF4B" "D3DX56; hsa:80174; Q8NFT6; Q8TEX0; Q96B19; Q9H912" "" "" "0" "0" "0.727" "1.076" "1.126" "0.746" "0.978" "0.932" "1.040" "0.838" "1.017" "295.2" "214.6" "317.6" "332.3" "220.3" "288.5" "275.0" "306.9" "247.2" "300.1" "" "" "" "" "" "" "" "" "" "" "265.4" "173.7" "287.3" "324.4" "181.8" "288.5" "205.9" "271.1" "221.2" "107.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8471021813070421568" "False" "Low" "IsMasterProtein" "P10074" "Telomere zinc finger-associated protein OS=Homo sapiens OX=9606 GN=ZBTB48 PE=1 SV=2" "0.054" "False" "1.327" "1" "1" "2" "1" "688" "77.0" "8.18" "4.85" "1" "cell organization and biogenesis;DNA metabolism;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651" "3104" "ENSG00000204859" "ZBTB48" "P10074; Q5SY19" "" "" "0" "0" "0.929" "0.876" "0.708" "0.787" "0.753" "0.792" "0.828" "0.721" "0.785" "398.3" "370.0" "349.1" "282.1" "313.4" "299.9" "315.6" "329.7" "287.3" "312.6" "" "" "" "" "" "" "" "" "" "" "358.1" "299.4" "315.8" "275.4" "258.6" "299.9" "236.3" "291.2" "257.0" "111.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1215487394628666745" "False" "Low" "IsMasterProtein" "Q9UL52" "Transmembrane protease serine 11E OS=Homo sapiens OX=9606 GN=TMPRSS11E PE=1 SV=2" "0.054" "False" "1.326" "2" "1" "1" "1" "423" "47.7" "8.59" "2.25" "1" "protein metabolism;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00089, Pf01390" "28983" "ENSG00000087128" "TMPRSS11E" "A6NL71; hsa:28983; Q14DC8; Q6UW31; Q9UL52" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "495915042757567020" "False" "Low" "IsMasterProtein" "Q9ULJ1" "Protein BCAP OS=Homo sapiens OX=9606 GN=ODF2L PE=1 SV=2" "0.055" "False" "1.323" "1" "1" "1" "1" "636" "73.7" "6.48" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytoskeleton;other cell component" "" "" "57489" "ENSG00000122417" "ODF2L" "A8MU56; B4E037; hsa:57489; Q05C40; Q5BJG5; Q5TBX3; Q5TBX4; Q86X31; Q9ULJ1" "" "" "0" "0" "0.905" "1.017" "1.126" "1.032" "1.110" "1.432" "1.106" "1.178" "1.120" "84.2" "76.2" "85.6" "94.8" "86.9" "93.4" "120.5" "93.1" "99.2" "94.3" "" "" "" "" "" "" "" "" "" "" "75.7" "61.7" "77.4" "92.5" "71.7" "93.4" "90.2" "82.2" "88.7" "33.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2758499994714669549" "False" "Low" "IsMasterProtein" "P04275" "von Willebrand factor OS=Homo sapiens OX=9606 GN=VWF PE=1 SV=4" "0.055" "False" "1.323" "0" "1" "1" "1" "2813" "309.1" "5.48" "2.50" "1" "cell adhesion;stress response;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00092, Pf00093, Pf00094, Pf01826, Pf08742, Pf16164" "7450" "ENSG00000110799" "VWF" "hsa:7450; P04275; Q8TCE8; Q99806" "Blood clotting cascade; Focal adhesion; Dengue-2 interactions with complement and coagulation cascades; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; 22q11.2 copy number variation syndrome; Complement and coagulation cascades" "Integrin cell surface interactions; Platelet degranulation ; Signaling by BRAF and RAF1 fusions; Signaling by moderate kinase activity BRAF mutants; Paradoxical activation of RAF signaling by kinase inactive BRAF; Signaling downstream of RAS mutants; Signaling by RAF1 mutants; Platelet Adhesion to exposed collagen; Intrinsic Pathway of Fibrin Clot Formation; Defective F8 cleavage by thrombin; Defective F8 binding to von Willebrand factor; MAP2K and MAPK activation; Signaling by high-kinase activity BRAF mutants; GP1b-IX-V activation signalling; Enhanced cleavage of VWF variant by ADAMTS13; Enhanced binding of GP1BA variant to VWF multimer:collagen ; Defective VWF cleavage by ADAMTS13 variant; Defective VWF binding to collagen type I ; Defective binding of VWF variant to GPIb:IX:V; GRB2:SOS provides linkage to MAPK signaling for Integrins ; p130Cas linkage to MAPK signaling for integrins" "30" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6643122719444543200" "False" "Low" "IsMasterProtein" "Q96CB8" "Integrator complex subunit 12 OS=Homo sapiens OX=9606 GN=INTS12 PE=1 SV=1" "0.055" "False" "1.322" "2" "1" "1" "1" "462" "48.8" "9.69" "0.00" "1" "RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus" "other molecular function" "Pf00628" "57117" "ENSG00000138785" "INTS12" "B2RC48; hsa:57117; Q3B6Z3; Q96CB8; Q9HD71" "" "RNA polymerase II transcribes snRNA genes" "1" "0" "1.194" "1.167" "1.417" "1.067" "1.105" "1.240" "1.274" "1.209" "1.674" "27.5" "32.9" "32.1" "39.0" "29.4" "30.4" "34.2" "35.1" "33.3" "46.1" "" "" "" "" "" "" "" "" "" "" "24.8" "26.6" "29.1" "38.1" "24.3" "30.4" "25.6" "31.0" "29.8" "16.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7557480247223307302" "False" "Low" "IsMasterProtein" "O94806" "Serine/threonine-protein kinase D3 OS=Homo sapiens OX=9606 GN=PRKD3 PE=1 SV=1" "0.055" "False" "1.319" "2" "1" "1" "1" "890" "100.4" "6.87" "2.03" "1" "protein metabolism;other metabolic processes;signal transduction" "plasma membrane;other membranes;cytosol;nucleus" "kinase activity;other molecular function" "Pf00069, Pf00130, Pf00169" "23683" "ENSG00000115825" "PRKD3" "D6W587; hsa:23683; O94806; Q53TR7; Q8NEL8" "G protein signaling pathways; Hippo signaling regulation pathways; Chronic hyperglycemia impairment of neuron function" "Sphingolipid de novo biosynthesis" "4" "0" "0.940" "1.001" "0.911" "0.856" "0.707" "0.925" "0.857" "0.815" "0.877" "61.8" "58.1" "61.9" "56.3" "52.9" "43.6" "57.1" "53.0" "50.4" "54.2" "" "" "" "" "" "" "" "" "" "" "55.5" "47.0" "56.0" "54.9" "43.6" "43.6" "42.8" "46.8" "45.1" "19.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4523717261131920154" "False" "Low" "IsMasterProtein" "Q8NEZ4" "Histone-lysine N-methyltransferase 2C OS=Homo sapiens OX=9606 GN=KMT2C PE=1 SV=3" "0.055" "False" "1.317" "0" "1" "1" "1" "4911" "541.0" "6.49" "2.13" "1" "cell organization and biogenesis;other metabolic processes;other biological processes" "cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf00628, Pf00856, Pf05964, Pf05965, Pf13771, Pf13832" "58508" "ENSG00000055609" "KMT2C" "hsa:58508; Q8NC02; Q8NDF6; Q8NEZ4; Q9H9P4; Q9NR13; Q9P222; Q9UDR7" "Histone modifications; Pathways affected in adenoid cystic carcinoma; 16p11.2 proximal deletion syndrome; Pleural mesothelioma; Kleefstra syndrome" "Activation of anterior HOX genes in hindbrain development during early embryogenesis; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Formation of WDR5-containing histone-modifying complexes; PKMTs methylate histone lysines" "9" "0" "1.090" "1.006" "0.931" "1.204" "1.095" "1.176" "0.959" "1.044" "0.828" "97.8" "106.5" "98.4" "91.0" "117.7" "107.1" "114.9" "93.7" "102.0" "80.9" "" "" "" "" "" "" "" "" "" "" "87.9" "86.2" "89.0" "88.9" "97.1" "107.1" "86.1" "82.8" "91.3" "28.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4373504798127132024" "False" "Low" "IsMasterProtein" "Q8IYJ3" "Synaptotagmin-like protein 1 OS=Homo sapiens OX=9606 GN=SYTL1 PE=1 SV=1" "0.055" "False" "1.315" "2" "1" "1" "1" "562" "61.8" "5.48" "2.21" "1" "transport" "plasma membrane;other membranes;ER/Golgi;other cell component" "signal transduction activity or receptor binding;other molecular function" "Pf00168" "84958" "ENSG00000142765" "SYTL1" "hsa:84958; Q5SSC9; Q8IYJ3; Q96BB6; Q96GU6; Q96S89; Q96SI0" "Deregulation of Rab and Rab effector genes in bladder cancer" "TBC/RABGAPs" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7317543867114186202" "False" "Low" "IsMasterProtein" "Q86VH2" "Kinesin-like protein KIF27 OS=Homo sapiens OX=9606 GN=KIF27 PE=1 SV=1" "0.055" "False" "1.315" "1" "1" "1" "1" "1401" "160.2" "7.28" "0.00" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00225" "55582" "ENSG00000165115" "KIF27" "B2RTR8; hsa:55582; Q5T6W0; Q86VH0; Q86VH1; Q86VH2; Q9UF54" "" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "2" "0" "0.858" "0.956" "0.951" "1.318" "0.997" "1.216" "1.182" "1.253" "0.936" "27.7" "23.8" "26.5" "26.3" "36.5" "27.6" "33.7" "32.7" "34.7" "25.9" "" "" "" "" "" "" "" "" "" "" "24.9" "19.2" "23.9" "25.7" "30.1" "27.6" "25.2" "28.9" "31.1" "9.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5017693853216972141" "False" "Low" "IsMasterProtein" "Q969S3" "Cytoplasmic 60S subunit biogenesis factor ZNF622 OS=Homo sapiens OX=9606 GN=ZNF622 PE=1 SV=1" "0.056" "False" "1.308" "2" "1" "1" "1" "477" "54.2" "6.15" "2.46" "1" "signal transduction;other biological processes" "cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf12171, Pf12756" "90441" "ENSG00000173545" "ZNF622" "hsa:90441; Q969S3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1435707363815542229" "False" "Low" "IsMasterProtein" "Q9ULG1" "Chromatin-remodeling ATPase INO80 OS=Homo sapiens OX=9606 GN=INO80 PE=1 SV=2" "0.056" "False" "1.305" "1" "1" "1" "1" "1556" "176.6" "9.50" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;stress response;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00176, Pf00271, Pf13892" "54617" "ENSG00000128908" "INO80" "A6H8X4; hsa:54617; Q9NTG6; Q9ULG1" "" "UCH proteinases; DNA Damage Recognition in GG-NER" "2" "0" "0.956" "0.816" "1.002" "0.937" "0.617" "1.051" "0.843" "0.836" "1.159" "28.3" "27.0" "23.1" "28.3" "26.5" "17.4" "29.7" "23.8" "23.6" "32.7" "" "" "" "" "" "" "" "" "" "" "25.4" "21.9" "20.9" "27.6" "21.9" "17.4" "22.2" "21.0" "21.1" "11.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1009047956554057166" "False" "Low" "IsMasterProtein" "Q12756" "Kinesin-like protein KIF1A OS=Homo sapiens OX=9606 GN=KIF1A PE=1 SV=2" "0.057" "False" "1.304" "1" "1" "1" "1" "1690" "190.9" "6.21" "0.00" "1" "transport;other biological processes" "other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00169, Pf00225, Pf00498, Pf12423, Pf12473, Pf16183" "547" "ENSG00000130294" "KIF1A" "B0I1S5; F5H045; hsa:547; O95068; Q12756; Q13355; Q14752; Q2NKJ6; Q4LE42; Q53T78; Q59GH1; Q63Z40; Q6P1R9; Q7KZ57" "2q37 copy number variation syndrome" "COPI-dependent Golgi-to-ER retrograde traffic; Kinesins" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5953737465852294599" "False" "Low" "IsMasterProtein" "O75493" "Carbonic anhydrase-related protein 11 OS=Homo sapiens OX=9606 GN=CA11 PE=1 SV=2" "0.057" "False" "1.303" "3" "1" "1" "1" "328" "36.2" "9.74" "2.16" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00194" "770" "ENSG00000063180" "CA11" "hsa:770; O60596; O75493; Q6FHI1; Q9UEC4" "IL-18 signaling pathway" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7609283554603105172" "False" "Low" "IsMasterProtein" "Q9UFD9" "RIMS-binding protein 3A OS=Homo sapiens OX=9606 GN=RIMBP3 PE=1 SV=4" "0.057" "False" "1.302" "1" "1" "1" "1" "1639" "180.6" "6.89" "0.00" "1" "other biological processes" "cytoskeleton;nucleus;other cell component" "signal transduction activity or receptor binding" "Pf07653" "85376" "ENSG00000275793" "RIMBP3" "hsa:85376; Q8IYP7; Q9BY94; Q9UFD9; Q9UFQ5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5320460450768777920" "False" "Low" "IsMasterProtein" "P11926" "Ornithine decarboxylase OS=Homo sapiens OX=9606 GN=ODC1 PE=1 SV=2" "0.057" "False" "1.301" "2" "1" "1" "1" "461" "51.1" "5.26" "2.30" "1" "cell cycle OR cell proliferation;other metabolic processes;developmental processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00278, Pf02784" "4953" "ENSG00000115758" "ODC1" "hsa:4953; P11926; Q53TU3; Q6LDS9" "Methionine de novo and salvage pathway; Amino acid metabolism" "Regulation of ornithine decarboxylase (ODC)" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5984006583607324295" "False" "Low" "IsMasterProtein" "P50553" "Achaete-scute homolog 1 OS=Homo sapiens OX=9606 GN=ASCL1 PE=1 SV=2" "0.057" "False" "1.294" "4" "1" "1" "1" "236" "25.4" "8.79" "2.22" "1" "cell cycle OR cell proliferation;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00010" "429" "ENSG00000139352" "ASCL1" "A8K3C4; hsa:429; P50553; Q9BQ30" "Neural crest differentiation; Dopaminergic neurogenesis; Kallmann syndrome; 2q37 copy number variation syndrome; Neurogenesis regulation in the olfactory epithelium; Sudden infant death syndrome (SIDS) susceptibility pathways" "NGF-stimulated transcription" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5249923035871806906" "False" "Low" "IsMasterProtein" "O60759" "Cytohesin-interacting protein OS=Homo sapiens OX=9606 GN=CYTIP PE=1 SV=2" "0.058" "False" "1.293" "2" "1" "1" "1" "359" "40.0" "6.99" "1.86" "1" "other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "" "Pf00595" "9595" "ENSG00000115165" "CYTIP" "B4DWH9; hsa:9595; O60759; Q15630; Q8NE32" "Amplification and expansion of oncogenic pathways as metastatic traits" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5314510564682491561" "False" "Low" "IsMasterProtein" "Q6ZV29" "Patatin-like phospholipase domain-containing protein 7 OS=Homo sapiens OX=9606 GN=PNPLA7 PE=1 SV=4" "0.058" "False" "1.291" "1" "1" "1" "1" "1317" "145.6" "7.74" "2.28" "1" "other metabolic processes" "other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00027, Pf01734" "375775" "ENSG00000130653" "PNPLA7" "B5MDD3; hsa:375775; Q5T364; Q658X0; Q658Y3; Q6ZTS1; Q6ZV29; Q86YU8; Q8TAY5; Q96N75; Q9H7N5" "" "Glycerophospholipid catabolism" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4791069774000483353" "False" "Low" "IsMasterProtein" "Q2TB10" "Zinc finger protein 800 OS=Homo sapiens OX=9606 GN=ZNF800 PE=1 SV=1" "0.058" "False" "1.290" "1" "1" "1" "1" "664" "75.2" "9.47" "1.66" "1" "developmental processes;other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf12874, Pf16622, Pf16624" "168850" "ENSG00000048405" "ZNF800" "hsa:168850; Q2TB10; Q9HBN0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "411188500467343645" "False" "Low" "IsMasterProtein" "Q92833" "Protein Jumonji OS=Homo sapiens OX=9606 GN=JARID2 PE=1 SV=2" "0.058" "False" "1.287" "1" "1" "1" "1" "1246" "138.6" "9.38" "3.12" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "mitochondrion;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf01388, Pf02373, Pf02375, Pf02928" "3720" "ENSG00000008083" "JARID2" "A8K9Z6; B7Z5S5; B7Z8L0; hsa:3720; Q5U5L5; Q86X63; Q92833" "Endoderm differentiation; Mesodermal commitment pathway; Interactome of polycomb repressive complex 2 (PRC2) ; Orexin receptor pathway" "PRC2 methylates histones and DNA" "5" "0" "0.782" "0.757" "0.774" "0.606" "1.186" "0.548" "0.723" "0.778" "0.631" "246.8" "193.0" "186.8" "191.0" "149.6" "292.8" "135.2" "178.4" "192.1" "155.6" "" "" "" "" "" "" "" "" "" "" "221.9" "156.2" "169.0" "186.4" "123.5" "292.8" "101.2" "157.6" "171.9" "55.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5238117067154294467" "False" "Low" "IsMasterProtein" "Q8N9W6" "Protein boule-like OS=Homo sapiens OX=9606 GN=BOLL PE=1 SV=2" "0.059" "False" "1.285" "2" "1" "1" "1" "283" "31.3" "7.11" "3.15" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "nucleic acid binding activity;other molecular function" "Pf00076" "66037" "ENSG00000152430" "BOLL" "B4DZA4; hsa:66037; Q0JW32; Q53T62; Q8N9W6; Q969U3" "" "" "0" "0" "0.968" "1.002" "0.963" "1.002" "0.974" "0.948" "0.893" "1.130" "1.032" "174.8" "169.3" "175.2" "168.4" "175.1" "170.3" "165.8" "156.1" "197.6" "180.4" "" "" "" "" "" "" "" "" "" "" "157.2" "137.0" "158.5" "164.4" "144.5" "170.3" "124.1" "137.9" "176.8" "64.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8824832017250777956" "False" "Low" "IsMasterProtein" "Q8TBZ3" "WD repeat-containing protein 20 OS=Homo sapiens OX=9606 GN=WDR20 PE=1 SV=2" "0.059" "False" "1.282" "2" "1" "1" "1" "569" "62.9" "8.00" "3.02" "1" "" "nucleus;other cell component" "enzyme regulator activity" "Pf00400" "91833" "ENSG00000140153" "WDR20" "B4DN18; E7EUY8; F8W9S4; G3V2F8; G3V5R0; H0YJJ1; hsa:91833; Q86TU2; Q8NCN7; Q8TBZ3; Q8WXX2; Q9UF86" "" "Ub-specific processing proteases" "1" "0" "1.122" "1.009" "1.058" "1.078" "1.082" "1.065" "0.944" "1.164" "1.078" "97.4" "109.2" "98.2" "103.0" "104.9" "105.4" "103.7" "92.0" "113.3" "105.0" "" "" "" "" "" "" "" "" "" "" "87.5" "88.4" "88.9" "100.5" "86.6" "105.4" "77.6" "81.2" "101.4" "37.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "308542735586844623" "False" "Low" "IsMasterProtein" "Q53FP2" "Novel acetylcholine receptor chaperone OS=Homo sapiens OX=9606 GN=TMEM35A PE=1 SV=2" "0.060" "False" "1.278" "4" "1" "1" "1" "167" "18.4" "10.08" "2.47" "1" "cell organization and biogenesis;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle;other cell component" "other molecular function" "" "59353" "ENSG00000126950" "TMEM35A" "hsa:59353; Q53FP2; Q9H7Y3" "" "" "0" "0" "0.923" "1.088" "0.880" "0.880" "0.768" "0.864" "0.901" "0.861" "0.549" "216.1" "199.4" "235.1" "190.1" "190.2" "166.0" "186.7" "194.7" "186.0" "118.7" "" "" "" "" "" "" "" "" "" "" "194.3" "161.4" "212.6" "185.6" "156.9" "166.0" "139.8" "172.0" "166.4" "42.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4825116035956365354" "False" "Low" "IsMasterProtein" "P0C7P0" "CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Homo sapiens OX=9606 GN=CISD3 PE=1 SV=1" "0.061" "False" "1.276" "10" "1" "1" "1" "127" "14.2" "10.55" "0.00" "1" "protein metabolism;other metabolic processes" "mitochondrion" "other molecular function" "Pf09360" "284106" "ENSG00000274768; ENSG00000277972" "CISD3" "hsa:284106; P0C7P0" "17q12 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "Not Found" "High" "Not Found" "High" "Not Found" "High" "High" "Not Found" "Not Found" "1" "" "7542471958177645128" "False" "Low" "IsMasterProtein" "Q8TBC3" "SH3KBP1-binding protein 1 OS=Homo sapiens OX=9606 GN=SHKBP1 PE=1 SV=2" "0.061" "False" "1.275" "2" "1" "1" "1" "707" "76.3" "8.28" "0.00" "1" "cell organization and biogenesis;other biological processes" "other cytoplasmic organelle" "other molecular function" "Pf02214" "92799" "ENSG00000160410" "SHKBP1" "Q8N2I6; Q8TBC3; Q8WY93; Q96IB8" "" "CDC42 GTPase cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8157720001899261977" "False" "Low" "IsMasterProtein" "Q8NEM7" "Transcription factor SPT20 homolog OS=Homo sapiens OX=9606 GN=SUPT20H PE=1 SV=2" "0.061" "False" "1.273" "1" "1" "1" "1" "779" "85.7" "8.48" "2.88" "1" "other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12090" "55578" "ENSG00000102710" "SUPT20H" "E7ER46; hsa:55578; Q71RF3; Q8NEM7; Q9Y6A6" "" "HATs acetylate histones" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7363067231999674496" "False" "Low" "IsMasterProtein" "Cont_P09870" "Clostripain OS=Hathewaya histolytica OX=1498 GN=cloSI PE=1 SV=2" "0.061" "True" "1.273" "2" "1" "1" "1" "526" "59.7" "5.38" "2.17" "1" "protein metabolism" "" "other molecular function" "Pf03415" "" "" "cloSI; cloSI_2" "A0A4U9RR22; ag:CAA45212; hhw:NCTC503_01794; P09869; P09870" "" "" "0" "0" "0.916" "0.997" "0.661" "0.694" "0.740" "0.785" "0.801" "0.710" "0.539" "207.2" "189.7" "206.6" "136.9" "143.8" "153.2" "162.6" "165.9" "147.0" "111.8" "" "" "" "" "" "" "" "" "" "" "186.3" "153.5" "186.9" "133.6" "118.7" "153.2" "121.7" "146.6" "131.5" "39.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2839479604527877959" "False" "Low" "IsMasterProtein" "Q99828" "Calcium and integrin-binding protein 1 OS=Homo sapiens OX=9606 GN=CIB1 PE=1 SV=4" "0.061" "False" "1.269" "4" "1" "1" "1" "191" "21.7" "4.78" "2.25" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "" "10519" "ENSG00000185043" "CIB1" "B5BU40; H6WJF3; hsa:10519; O00693; O00735; Q6IB49; Q96J54; Q99828; Q99971" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6225223608593832705" "False" "Low" "IsMasterProtein" "Q99856" "AT-rich interactive domain-containing protein 3A OS=Homo sapiens OX=9606 GN=ARID3A PE=1 SV=2" "0.061" "False" "1.268" "2" "1" "1" "1" "593" "62.9" "4.91" "2.52" "1" "other biological processes" "other membranes;cytosol;nucleus" "nucleic acid binding activity;other molecular function" "Pf01388" "1820" "ENSG00000116017" "ARID3A" "hsa:1820; Q5I858; Q6P9C6; Q8IZA7; Q8N4Z3; Q99856" "HDAC6 interactions in the central nervous system" "TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest" "2" "0" "1.625" "1.321" "1.717" "1.917" "1.866" "1.370" "1.621" "1.281" "10.248" "10.3" "16.7" "13.6" "17.7" "19.7" "19.2" "14.1" "16.7" "13.2" "105.4" "" "" "" "" "" "" "" "" "" "" "9.2" "13.5" "12.3" "17.2" "16.3" "19.2" "10.5" "14.7" "11.8" "37.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6482915766350322597" "False" "Low" "IsMasterProtein" "O75309" "Cadherin-16 OS=Homo sapiens OX=9606 GN=CDH16 PE=1 SV=1" "0.061" "False" "1.268" "2" "1" "1" "1" "829" "89.9" "4.96" "2.64" "1" "cell adhesion" "plasma membrane;other membranes" "other molecular function" "Pf00028" "1014" "ENSG00000166589" "CDH16" "B4DPA8; H3BPD3; hsa:1014; O75309; Q6UW93" "TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition; Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "" "4" "0" "0.818" "0.947" "0.822" "0.810" "0.803" "0.869" "0.847" "0.929" "0.797" "239.8" "196.0" "227.0" "197.0" "194.1" "192.5" "208.3" "203.2" "222.6" "191.1" "" "" "" "" "" "" "" "" "" "" "215.6" "158.6" "205.4" "192.3" "160.2" "192.5" "156.0" "179.4" "199.2" "68.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2234417344017159128" "False" "Low" "IsMasterProtein" "A8K8P3" "Protein SFI1 homolog OS=Homo sapiens OX=9606 GN=SFI1 PE=1 SV=2" "0.061" "False" "1.268" "1" "1" "1" "1" "1242" "147.6" "10.81" "2.34" "1" "" "cytosol;cytoskeleton" "other molecular function" "" "9814" "ENSG00000198089" "SFI1" "A1L373; A1L387; A2A2L2; A8K8P3; B1AKL9; B5MDB7; B7Z1V6; B7Z8G3; B7ZBE2; B7ZBE3; hsa:9814; O60289; Q2TAN8; Q5W1B5; Q86TK0; Q8N4U8; Q8N8C1; Q8WU14" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "1.298" "0.854" "0.978" "1.249" "1.019" "1.023" "1.167" "1.145" "0.957" "106.4" "138.2" "91.0" "104.1" "132.9" "108.5" "108.9" "124.2" "121.9" "101.9" "" "" "" "" "" "" "" "" "" "" "95.7" "111.8" "82.3" "101.6" "109.7" "108.5" "81.5" "109.7" "109.1" "36.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5420473420696374140" "False" "Low" "IsMasterProtein" "Q3KQZ1" "Solute carrier family 25 member 35 OS=Homo sapiens OX=9606 GN=SLC25A35 PE=1 SV=1" "0.061" "False" "1.265" "3" "1" "1" "1" "300" "32.4" "9.11" "2.47" "1" "" "other membranes;mitochondrion" "" "Pf00153" "399512" "ENSG00000125434" "SLC25A35" "hsa:399512; Q3KQZ1; Q494X5; Q6RGS3; Q8N7Y5" "" "" "0" "0" "0.980" "0.920" "0.919" "1.149" "0.874" "1.103" "0.958" "0.911" "0.795" "136.9" "134.2" "126.0" "125.8" "157.3" "119.6" "151.0" "131.1" "124.7" "108.8" "" "" "" "" "" "" "" "" "" "" "123.1" "108.6" "113.9" "122.8" "129.8" "119.6" "113.1" "115.8" "111.6" "38.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658531397238436427" "False" "Low" "IsMasterProtein" "Q7Z2Z1" "Treslin OS=Homo sapiens OX=9606 GN=TICRR PE=1 SV=2" "0.061" "False" "1.264" "1" "1" "1" "1" "1910" "210.7" "8.78" "1.96" "1" "cell cycle OR cell proliferation;DNA metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf15292" "90381" "ENSG00000140534" "TICRR" "B2RE07; B3KVV9; D3IUT4; hsa:90381; Q7Z2Z1; Q8N4X8; Q8NCH6; Q9BU55" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4211098345224806896" "False" "Low" "IsMasterProtein" "Q5H9L2" "Transcription elongation factor A protein-like 5 OS=Homo sapiens OX=9606 GN=TCEAL5 PE=1 SV=1" "0.061" "False" "1.263" "4" "1" "1" "1" "206" "23.3" "4.81" "1.70" "1" "" "nucleus" "" "Pf04538" "340543" "ENSG00000204065" "TCEAL5" "A2RUJ4; hsa:340543; Q5H9L2" "" "" "0" "0" "1.304" "1.278" "1.020" "1.189" "1.333" "1.394" "0.903" "1.102" "1.270" "26.6" "34.7" "34.0" "27.1" "31.6" "35.5" "37.1" "24.0" "29.3" "33.8" "" "" "" "" "" "" "" "" "" "" "23.9" "28.1" "30.7" "26.5" "26.1" "35.5" "27.8" "21.2" "26.2" "12.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5345064234095309985" "False" "Low" "IsMasterProtein" "Q16236" "Nuclear factor erythroid 2-related factor 2 OS=Homo sapiens OX=9606 GN=NFE2L2 PE=1 SV=3" "0.061" "False" "1.263" "1" "1" "1" "1" "605" "67.8" "4.78" "2.29" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol;cytoskeleton;ER/Golgi;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf03131" "4780" "ENSG00000116044" "NFE2L2" "B2RBU2; B4E338; E9PGJ7; hsa:4780; Q16236; Q53RW6; Q59HH2; Q96F71" "Quercetin and Nf-kB / AP-1 induced apoptosis; Aryl hydrocarbon receptor pathway; Mesodermal commitment pathway; Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; NRF2 pathway; Transcriptional activation by NRF2 in response to phytochemicals; Photodynamic therapy-induced AP-1 survival signaling; Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling; Photodynamic therapy-induced unfolded protein response; Lung fibrosis; Interactions between LOXL4 and oxidative stress pathway; Oxidative stress response; Hereditary leiomyomatosis and renal cell carcinoma pathway; Ethanol metabolism production of ROS by CYP2E1; NRF2-ARE regulation; Male infertility; Head and neck squamous cell carcinoma; Vitamin D-sensitive calcium signaling in depression; CAMKK2 pathway; Unfolded protein response; Orexin receptor pathway; Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway; Autophagy in pancreatic ductal adenocarcinoma" "Neddylation; KEAP1-NFE2L2 pathway; NFE2L2 regulating tumorigenic genes; Potential therapeutics for SARS; Heme signaling; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2; Regulation of HMOX1 expression and activity; NFE2L2 regulating anti-oxidant/detoxification enzymes; NFE2L2 regulating MDR associated enzymes; Nuclear events mediated by NFE2L2; NFE2L2 regulates pentose phosphate pathway genes; NFE2L2 regulating inflammation associated genes; NFE2L2 regulating ER-stress associated genes; Regulation of NFE2L2 gene expression; NFE2L2 regulating TCA cycle genes" "39" "0" "0.937" "0.941" "0.961" "1.293" "1.047" "0.986" "0.997" "1.192" "0.764" "162.0" "151.8" "152.5" "155.7" "209.4" "169.6" "159.8" "161.5" "193.2" "123.8" "" "" "" "" "" "" "" "" "" "" "145.7" "122.8" "137.9" "152.0" "172.8" "169.6" "119.7" "142.6" "172.8" "44.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2776694094715301216" "False" "Low" "IsMasterProtein" "Q6UXD5" "Seizure 6-like protein 2 OS=Homo sapiens OX=9606 GN=SEZ6L2 PE=1 SV=2" "0.061" "False" "1.263" "2" "1" "1" "1" "910" "97.5" "4.89" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf00084, Pf00431" "26470" "ENSG00000174938" "SEZ6L2" "B7Z1N0; F5H293; H7BXQ6; hsa:26470; Q6UXD5; Q9BW82; Q9UJ45; Q9UJ46; Q9UJ47" "16p11.2 proximal deletion syndrome" "" "1" "0" "1.053" "0.852" "0.835" "1.215" "1.006" "0.876" "0.715" "0.967" "1.092" "26.9" "28.4" "23.0" "22.5" "32.7" "27.1" "23.6" "19.3" "26.1" "29.4" "" "" "" "" "" "" "" "" "" "" "24.2" "23.0" "20.8" "22.0" "27.0" "27.1" "17.7" "17.0" "23.3" "10.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6181035115261308292" "False" "Low" "IsMasterProtein" "Q8N7X0" "Androglobin OS=Homo sapiens OX=9606 GN=ADGB PE=1 SV=3" "0.061" "False" "1.261" "1" "1" "1" "1" "1667" "189.6" "8.31" "0.00" "1" "protein metabolism;other biological processes" "cytoskeleton" "other molecular function" "Pf00648" "79747" "ENSG00000118492" "ADGB" "hsa:79747; Q5T402; Q5T904; Q5T905; Q8N7X0" "" "" "0" "0" "0.854" "1.030" "0.721" "0.802" "0.740" "0.803" "0.783" "0.767" "0.643" "312.6" "266.9" "321.9" "225.4" "250.8" "231.2" "251.0" "244.8" "239.8" "200.9" "" "" "" "" "" "" "" "" "" "" "281.0" "216.0" "291.2" "220.0" "207.0" "231.2" "187.9" "216.2" "214.6" "71.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5710815529521285644" "False" "Low" "IsMasterProtein" "Q9BQ70" "Ribosome quality control complex subunit TCF25 OS=Homo sapiens OX=9606 GN=TCF25 PE=1 SV=1" "0.061" "False" "1.261" "1" "1" "1" "1" "676" "76.6" "6.35" "1.91" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04910" "22980" "ENSG00000141002" "TCF25" "hsa:22980; Q2MK75; Q9BQ70; Q9UPV3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5216649648598293660" "False" "Low" "IsMasterProtein" "Q96GD3" "Polycomb protein SCMH1 OS=Homo sapiens OX=9606 GN=SCMH1 PE=1 SV=1" "0.061" "False" "1.261" "1" "1" "2" "1" "660" "73.3" "9.25" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus" "other molecular function" "Pf00536, Pf02820, Pf12140, Pf17208" "22955" "ENSG00000010803" "SCMH1" "B4DRQ8; hsa:22955; Q5VT76; Q6IAJ4; Q8WU48; Q96GD3; Q9UKM5; Q9UKM6" "" "" "0" "0" "0.956" "0.867" "0.968" "1.007" "0.894" "0.997" "0.823" "0.990" "0.712" "246.7" "236.0" "214.0" "238.7" "248.5" "220.5" "246.0" "203.0" "244.3" "175.7" "" "" "" "" "" "" "" "" "" "" "221.8" "190.9" "193.6" "233.0" "205.1" "220.5" "184.2" "179.3" "218.6" "62.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3834128013401961413" "False" "Low" "IsMasterProtein" "Q4L235" "Beta-alanine-activating enzyme OS=Homo sapiens OX=9606 GN=AASDH PE=1 SV=3" "0.062" "False" "1.260" "1" "1" "1" "1" "1098" "122.5" "7.24" "0.00" "1" "other metabolic processes" "" "other molecular function" "Pf00501, Pf00550, Pf13360, Pf13570" "132949" "ENSG00000157426" "AASDH" "A5D8V3; A5PL22; hsa:132949; Q4L235; Q63HK2; Q63HR7; Q6IPP8; Q6TFZ6; Q7Z5Y3; Q96BW4; Q9P064" "" "" "0" "0" "0.965" "0.962" "0.939" "0.921" "1.019" "0.790" "0.967" "1.060" "0.716" "329.4" "317.8" "317.1" "309.4" "303.3" "335.5" "260.2" "318.6" "349.3" "235.8" "" "" "" "" "" "" "" "" "" "" "296.2" "257.1" "286.8" "302.0" "250.3" "335.5" "194.8" "281.4" "312.5" "84.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4494459322637692894" "False" "Low" "IsMasterProtein" "Q5VSY0" "G kinase-anchoring protein 1 OS=Homo sapiens OX=9606 GN=GKAP1 PE=1 SV=2" "0.062" "False" "1.260" "3" "1" "1" "1" "366" "42.1" "8.82" "1.60" "1" "signal transduction;other biological processes" "ER/Golgi" "other molecular function" "" "80318" "ENSG00000165113" "GKAP1" "hsa:80318; Q5VSY0; Q96LI0; Q9BYI1; Q9BYI2; Q9H225" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1538784976841218653" "False" "Low" "IsMasterProtein" "Q8N5C6" "S1 RNA-binding domain-containing protein 1 OS=Homo sapiens OX=9606 GN=SRBD1 PE=1 SV=2" "0.062" "False" "1.259" "1" "1" "1" "1" "995" "111.7" "8.72" "2.12" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf00575, Pf09371, Pf12836, Pf16921, Pf17674" "55133" "ENSG00000068784" "SRBD1" "hsa:55133; Q53T56; Q8N5C6; Q96TA4; Q9NW11" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5273263949641690110" "False" "Low" "IsMasterProtein" "Q92630" "Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Homo sapiens OX=9606 GN=DYRK2 PE=1 SV=3" "0.062" "False" "1.256" "1" "1" "1" "1" "601" "66.6" "9.67" "0.00" "1" "protein metabolism;other metabolic processes;stress response;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "kinase activity;other molecular function" "Pf00069" "8445" "ENSG00000127334" "DYRK2" "B2R9V9; hsa:8445; Q92630; Q9BRB5" "T cell receptor and co-stimulatory signaling" "Regulation of TP53 Activity through Phosphorylation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3434352679315597621" "False" "Low" "IsMasterProtein" "O14524" "Nuclear envelope integral membrane protein 1 OS=Homo sapiens OX=9606 GN=NEMP1 PE=1 SV=2" "0.062" "False" "1.250" "3" "1" "1" "1" "444" "50.6" "6.93" "0.00" "1" "cell organization and biogenesis" "other membranes;nucleus" "" "Pf10225" "23306" "ENSG00000166881" "NEMP1" "hsa:23306; O14524; Q17R72; Q68DH0; Q6IQ25" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6064766288331426383" "False" "Low" "IsMasterProtein" "P06727" "Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4" "0.063" "False" "1.247" "2" "1" "1" "1" "396" "45.3" "5.38" "2.38" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;ER/Golgi;other cytoplasmic organelle;other cell component" "transporter activity;enzyme regulator activity;other molecular function" "Pf01442" "337" "ENSG00000110244" "APOA4" "A8MSL6; hsa:337; P06727; Q14CW8; Q6Q787" "Statin inhibition of cholesterol production; Familial hyperlipidemia type 1; Familial hyperlipidemia type 2; Familial hyperlipidemia type 3; Familial hyperlipidemia type 4; Familial hyperlipidemia type 5; Cholesterol metabolism; Enterocyte cholesterol metabolism" "Amyloid fiber formation; Retinoid metabolism and transport; Assembly of active LPL and LIPC lipase complexes; Chylomicron assembly; Chylomicron remodeling" "13" "0" "0.997" "1.077" "0.925" "1.078" "0.950" "1.192" "1.026" "1.024" "0.758" "96.6" "96.3" "104.1" "89.3" "104.2" "91.8" "115.1" "99.1" "98.9" "73.3" "" "" "" "" "" "" "" "" "" "" "86.8" "77.9" "94.1" "87.2" "85.9" "91.8" "86.2" "87.5" "88.5" "26.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "9202783158838613121" "False" "Low" "IsMasterProtein" "Q01740" "Flavin-containing monooxygenase 1 OS=Homo sapiens OX=9606 GN=FMO1 PE=1 SV=3" "0.063" "False" "1.246" "2" "1" "1" "1" "532" "60.3" "7.20" "0.00" "1" "other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00743" "2326" "ENSG00000010932" "FMO1" "A8K248; B7Z3P4; hsa:2326; Q01740; Q5QPT2; Q9UJC2" "Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs); Tamoxifen metabolism; Metapathway biotransformation Phase I and II" "Degradation of cysteine and homocysteine; FMO oxidises nucleophiles" "5" "0" "0.936" "0.850" "0.907" "1.391" "0.922" "1.054" "0.838" "1.052" "0.602" "40.2" "37.6" "34.1" "36.4" "55.8" "37.0" "42.3" "33.6" "42.2" "24.2" "" "" "" "" "" "" "" "" "" "" "36.1" "30.4" "30.9" "35.5" "46.1" "37.0" "31.7" "29.7" "37.8" "8.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6429829265109065011" "False" "Low" "IsMasterProtein" "Q63HR2" "Tensin-2 OS=Homo sapiens OX=9606 GN=TNS2 PE=1 SV=2" "0.063" "False" "1.245" "1" "1" "1" "1" "1409" "152.5" "8.35" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00017, Pf00130, Pf08416, Pf10409" "23371" "ENSG00000111077" "TNS2" "A2VDF2; A2VDF3; A2VDI8; A5PKY4; hsa:23371; Q2NL80; Q63HR2; Q76MW6; Q7Z5T9; Q8NFF9; Q8NFG0; Q96P25; Q9NT29; Q9UPS7" "" "" "0" "0" "0.917" "0.969" "1.079" "0.890" "1.417" "0.879" "0.879" "1.103" "0.661" "95.1" "87.2" "92.1" "102.5" "84.6" "134.7" "83.5" "83.6" "104.8" "62.8" "" "" "" "" "" "" "" "" "" "" "85.5" "70.5" "83.3" "100.1" "69.8" "134.7" "62.5" "73.8" "93.8" "22.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "465577355447641412" "False" "Low" "IsMasterProtein" "Q16515" "Acid-sensing ion channel 2 OS=Homo sapiens OX=9606 GN=ASIC2 PE=1 SV=1" "0.064" "False" "1.239" "1" "1" "1" "1" "512" "57.7" "5.19" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "transporter activity" "Pf00858" "40" "ENSG00000108684" "ASIC2" "E9PBX2; hsa:40; Q13553; Q16515; Q6DJU1; Q8N3E2" "17q12 copy number variation syndrome" "Stimuli-sensing channels" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6659318497686319615" "False" "Low" "IsMasterProtein" "Q8NAB2" "Kelch repeat and BTB domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KBTBD3 PE=1 SV=3" "0.065" "False" "1.233" "1" "1" "1" "1" "612" "69.8" "5.35" "0.00" "1" "" "" "" "Pf00651, Pf01344, Pf07707" "143879" "ENSG00000182359" "KBTBD3" "hsa:143879; Q6N066; Q86X38; Q8NAB2; Q96NK5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1975606799132573194" "False" "Low" "IsMasterProtein" "P47710" "Alpha-S1-casein OS=Homo sapiens OX=9606 GN=CSN1S1 PE=1 SV=1" "0.065" "False" "1.230" "4" "1" "1" "1" "185" "21.7" "5.38" "2.86" "1" "other biological processes" "non-structural extracellular" "" "" "1446" "ENSG00000126545" "CSN1S1" "A1A510; A1A511; E9PB60; hsa:1446; P47710; Q4PNR5" "" "Miscellaneous transport and binding events" "1" "0" "0.847" "1.288" "0.577" "0.723" "0.691" "0.547" "0.761" "0.646" "0.726" "293.1" "248.4" "377.4" "169.1" "212.0" "202.6" "160.2" "222.9" "189.4" "212.8" "" "" "" "" "" "" "" "" "" "" "263.5" "201.0" "341.4" "165.0" "174.9" "202.6" "119.9" "196.9" "169.5" "76.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7877308577362265482" "False" "Low" "IsMasterProtein" "Q8TED9" "Actin filament-associated protein 1-like 1 OS=Homo sapiens OX=9606 GN=AFAP1L1 PE=1 SV=2" "0.065" "False" "1.229" "2" "1" "1" "1" "768" "86.4" "6.80" "2.25" "1" "" "cytosol;cytoskeleton;other cell component" "other molecular function" "Pf00169" "134265" "ENSG00000157510" "AFAP1L1" "hsa:134265; Q08AN4; Q08AN5; Q8IW82; Q8N8Z5; Q8N9Q4; Q8TED9" "" "" "0" "0" "1.020" "0.989" "0.665" "0.665" "0.828" "0.830" "0.725" "0.731" "0.722" "248.7" "253.5" "245.8" "165.4" "165.4" "205.8" "206.5" "180.4" "181.8" "179.5" "" "" "" "" "" "" "" "" "" "" "223.6" "205.1" "222.4" "161.4" "136.5" "205.8" "154.6" "159.3" "162.7" "64.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8236633477379487928" "False" "Low" "IsMasterProtein" "Q9UPZ3" "BLOC-2 complex member HPS5 OS=Homo sapiens OX=9606 GN=HPS5 PE=1 SV=2" "0.068" "False" "1.223" "1" "1" "1" "1" "1129" "127.4" "5.54" "2.51" "1" "cell organization and biogenesis;stress response;transport;other biological processes" "cytosol;other cytoplasmic organelle;other cell component" "" "" "11234" "ENSG00000110756; ENSG00000288445" "HPS5" "A8K6J8; A8K8S1; D3DQX9; D3DQY0; hsa:11234; O95942; Q8N4U0; Q9UPZ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8685306356898503510" "False" "Low" "IsMasterProtein" "Q53EQ6" "Tigger transposable element-derived protein 5 OS=Homo sapiens OX=9606 GN=TIGD5 PE=1 SV=3" "0.068" "False" "1.222" "2" "1" "1" "1" "642" "69.2" "8.41" "0.00" "1" "" "nucleus" "nucleic acid binding activity" "Pf03184, Pf03221, Pf04218" "84948" "ENSG00000179886; ENSG00000278016" "TIGD5" "E7EWS2; hsa:84948; Q53EQ6; Q6NT83; Q8N5A1; Q96JW8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3811066710026793793" "False" "Low" "IsMasterProtein" "P21580" "Tumor necrosis factor alpha-induced protein 3 OS=Homo sapiens OX=9606 GN=TNFAIP3 PE=1 SV=1" "0.068" "False" "1.222" "2" "1" "1" "1" "790" "89.6" "8.22" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "nucleic acid binding activity;other molecular function" "Pf01754, Pf02338" "7128" "ENSG00000118503" "TNFAIP3" "B2R767; E1P588; hsa:7128; P21580; Q2HIX9; Q5VXQ7; Q9NSR6" "TNF-alpha signaling pathway; Vitamin D receptor pathway; Glucocorticoid receptor pathway; Nuclear receptors meta-pathway; Measles virus infection; IL-18 signaling pathway; Burn wound healing; Modulators of TCR signaling and T cell activation" "NOD1/2 Signaling Pathway; Regulation of TNFR1 signaling; TNFR1-induced NF-kappa-B signaling pathway; Negative regulators of DDX58/IFIH1 signaling; Ovarian tumor domain proteases; TNFR1-induced proapoptotic signaling" "14" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5759218457056628975" "False" "Low" "IsMasterProtein" "Q6NVH7" "ATPase SWSAP1 OS=Homo sapiens OX=9606 GN=SWSAP1 PE=1 SV=1" "0.068" "False" "1.220" "3" "1" "1" "1" "229" "24.3" "5.21" "2.29" "1" "DNA metabolism;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "" "126074" "ENSG00000173928" "SWSAP1" "hsa:126074; Q6NVH7; Q8NAM1" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6677968596851833833" "False" "Low" "IsMasterProtein" "Q9NXR8" "Inhibitor of growth protein 3 OS=Homo sapiens OX=9606 GN=ING3 PE=1 SV=2" "0.068" "False" "1.220" "3" "1" "1" "1" "418" "46.7" "6.27" "0.00" "1" "cell organization and biogenesis;other biological processes" "nucleus;other cell component" "other molecular function" "Pf12998" "54556" "ENSG00000071243" "ING3" "A8K790; hsa:54556; O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9NXR8; Q9P081" "" "HATs acetylate histones" "1" "0" "1.034" "0.995" "1.077" "0.960" "0.917" "0.897" "1.068" "1.191" "1.259" "35.5" "36.7" "35.3" "38.2" "34.1" "32.5" "31.8" "37.9" "42.2" "44.7" "" "" "" "" "" "" "" "" "" "" "31.9" "29.7" "31.9" "37.3" "28.1" "32.5" "23.8" "33.5" "37.8" "15.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8912838083063934850" "False" "Low" "IsMasterProtein" "Q8TBE7" "Solute carrier family 35 member G2 OS=Homo sapiens OX=9606 GN=SLC35G2 PE=1 SV=3" "0.068" "False" "1.219" "2" "1" "1" "1" "412" "46.4" "7.34" "2.24" "1" "" "plasma membrane;other membranes;ER/Golgi" "" "Pf00892" "80723" "ENSG00000168917" "SLC35G2" "B2RA80; D3DNE1; hsa:80723; Q8TBE7; Q9BWN4; Q9H0S6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7360552494888205350" "False" "Low" "IsMasterProtein" "Q9H5L6" "DNA transposase THAP9 OS=Homo sapiens OX=9606 GN=THAP9 PE=1 SV=2" "0.069" "False" "1.213" "1" "1" "1" "1" "903" "103.3" "9.13" "0.00" "1" "DNA metabolism;other metabolic processes" "" "nucleic acid binding activity;other molecular function" "Pf05485, Pf12017, Pf21787, Pf21788, Pf21789" "79725" "ENSG00000168152" "THAP9" "B3KRE2; hsa:79725; Q59AC9; Q9H5L6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8677179923960499603" "False" "Low" "IsMasterProtein" "Q86UD0" "Suppressor APC domain-containing protein 2 OS=Homo sapiens OX=9606 GN=SAPCD2 PE=1 SV=2" "0.069" "False" "1.211" "4" "1" "1" "1" "394" "42.6" "8.82" "2.08" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "" "Pf11414" "89958" "ENSG00000186193" "SAPCD2" "hsa:89958; Q86UD0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5609078604117945067" "False" "Low" "IsMasterProtein" "Q9H777" "Zinc phosphodiesterase ELAC protein 1 OS=Homo sapiens OX=9606 GN=ELAC1 PE=1 SV=2" "0.069" "False" "1.210" "3" "1" "1" "1" "363" "40.0" "6.79" "2.32" "1" "cell organization and biogenesis;protein metabolism;RNA metabolism OR transcription;other metabolic processes" "cytosol;nucleus" "other molecular function" "Pf00753" "55520" "ENSG00000141642" "ELAC1" "hsa:55520; Q9H777; Q9NS99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3330984120207852334" "False" "Low" "IsMasterProtein" "Q68DX3" "FERM and PDZ domain-containing protein 2 OS=Homo sapiens OX=9606 GN=FRMPD2 PE=1 SV=3" "0.070" "False" "1.208" "1" "1" "1" "1" "1309" "144.2" "6.74" "0.00" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "other molecular function" "Pf00373, Pf00595, Pf09379, Pf09380" "143162" "ENSG00000170324" "FRMPD2" "B7WNW0; B7ZML5; hsa:143162; Q2VY07; Q68DX3; Q6GMQ9; Q6ZN38; Q6ZWI2; Q8N5T9" "10q11.21q11.23 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "585618494427246926" "False" "Low" "IsMasterProtein" "Q5UE93" "Phosphoinositide 3-kinase regulatory subunit 6 OS=Homo sapiens OX=9606 GN=PIK3R6 PE=1 SV=1" "0.070" "False" "1.206" "1" "1" "1" "1" "754" "84.2" "7.64" "2.23" "1" "developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;cytosol" "enzyme regulator activity;kinase activity" "Pf10486" "146850" "ENSG00000276231" "PIK3R6" "hsa:146850; Q5UE93; Q658R3" "Microglia pathogen phagocytosis pathway; PI3K-Akt signaling pathway; Neural crest cell migration during development; Neural crest cell migration in cancer; Osteoblast differentiation and related diseases" "GPVI-mediated activation cascade; Synthesis of PIPs at the plasma membrane; G beta:gamma signalling through PI3Kgamma" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1406367612913778648" "False" "Low" "IsMasterProtein" "Q5VZV1" "Protein-lysine methyltransferase METTL21C OS=Homo sapiens OX=9606 GN=METTL21C PE=1 SV=1" "0.070" "False" "1.205" "4" "1" "1" "1" "264" "29.5" "4.93" "3.08" "1" "protein metabolism;other metabolic processes;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf10294" "196541" "ENSG00000139780" "METTL21C" "hsa:196541; Q5VZV1" "" "" "0" "0" "1.080" "1.093" "1.169" "1.041" "0.883" "1.053" "1.148" "0.976" "1.982" "196.1" "211.7" "214.3" "229.2" "204.1" "173.2" "206.4" "225.1" "191.4" "388.7" "" "" "" "" "" "" "" "" "" "" "176.3" "171.3" "193.8" "223.7" "168.4" "173.2" "154.5" "198.8" "171.2" "138.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "190648059904117416" "False" "Low" "IsMasterProtein" "Q9UQ90" "Mitochondrial inner membrane m-AAA protease component paraplegin OS=Homo sapiens OX=9606 GN=SPG7 PE=1 SV=2" "0.071" "False" "1.201" "2" "1" "1" "1" "795" "88.2" "8.69" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;developmental processes" "other membranes;mitochondrion;other cell component" "other molecular function" "Pf00004, Pf01434, Pf06480, Pf17862" "6687" "ENSG00000197912" "SPG7" "hsa:6687; O75756; Q2TB70; Q58F00; Q96IB0; Q9UQ90" "" "Mitochondrial protein degradation; Processing of SMDT1" "2" "0" "0.963" "0.910" "0.482" "0.636" "0.548" "0.540" "0.751" "0.430" "0.526" "39.1" "37.7" "35.6" "18.9" "24.9" "21.5" "21.1" "29.4" "16.8" "20.6" "" "" "" "" "" "" "" "" "" "" "35.2" "30.5" "32.2" "18.4" "20.5" "21.5" "15.8" "26.0" "15.0" "7.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7773792101669392702" "False" "Low" "IsMasterProtein" "O94880" "PHD finger protein 14 OS=Homo sapiens OX=9606 GN=PHF14 PE=1 SV=3" "0.071" "False" "1.201" "1" "1" "1" "1" "948" "106.9" "5.34" "2.44" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;developmental processes;other biological processes" "nucleus;other cell component" "other molecular function" "Pf00628, Pf13831, Pf13832" "9678" "ENSG00000106443" "PHF14" "A0A0U1RRH6; A7MCZ3; B4DI82; hsa:9678; O94880" "" "" "0" "0" "0.948" "0.895" "1.027" "0.916" "0.810" "0.878" "0.965" "0.845" "0.782" "252.1" "239.1" "225.7" "258.9" "230.9" "204.2" "221.3" "243.3" "212.9" "197.0" "" "" "" "" "" "" "" "" "" "" "226.6" "193.5" "204.1" "252.7" "190.5" "204.2" "165.7" "214.9" "190.5" "70.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8283098890502474545" "False" "Low" "IsMasterProtein" "Q9Y5T4" "DnaJ homolog subfamily C member 15 OS=Homo sapiens OX=9606 GN=DNAJC15 PE=1 SV=2" "0.071" "False" "1.199" "7" "1" "1" "1" "150" "16.4" "10.08" "2.42" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;mitochondrion" "other molecular function" "" "29103" "ENSG00000120675" "DNAJC15" "B2R4L0; hsa:29103; Q5T219; Q6X963; Q9Y5T4" "Glucocorticoid receptor pathway; Nuclear receptors meta-pathway" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1575128181987345078" "False" "Low" "IsMasterProtein" "Q9GZM5" "Protein YIPF3 OS=Homo sapiens OX=9606 GN=YIPF3 PE=1 SV=1" "0.071" "False" "1.199" "3" "1" "1" "1" "350" "38.2" "5.76" "2.54" "1" "other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "" "25844" "ENSG00000137207" "YIPF3" "hsa:25844; Q5JTD2; Q6FI85; Q8NI57; Q9GZM5; Q9NWE3; Q9Y3U9" "" "" "0" "0" "0.917" "1.128" "0.889" "0.840" "1.085" "1.202" "1.017" "1.004" "0.827" "49.5" "45.4" "55.8" "44.0" "41.6" "53.7" "59.5" "50.4" "49.7" "41.0" "" "" "" "" "" "" "" "" "" "" "44.5" "36.7" "50.5" "43.0" "34.3" "53.7" "44.6" "44.5" "44.5" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3564973388906415615" "False" "Low" "IsMasterProtein" "Q96DY7" "Mdm2-binding protein OS=Homo sapiens OX=9606 GN=MTBP PE=1 SV=1" "0.071" "False" "1.198" "1" "1" "1" "1" "904" "102.1" "7.77" "2.57" "1" "cell cycle OR cell proliferation;other biological processes" "other cell component" "" "Pf14918, Pf14919, Pf14920" "27085" "ENSG00000172167" "MTBP" "B4DUR5; hsa:27085; Q96DY7; Q9HA89" "" "" "0" "0" "0.912" "0.907" "0.898" "0.920" "0.802" "0.836" "0.848" "0.829" "0.736" "232.0" "211.7" "210.5" "208.4" "213.4" "186.1" "193.9" "196.9" "192.4" "170.7" "" "" "" "" "" "" "" "" "" "" "208.6" "171.3" "190.4" "203.4" "176.1" "186.1" "145.2" "173.9" "172.1" "60.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5479950461840362459" "False" "Low" "IsMasterProtein" "Q0VGL1" "Ragulator complex protein LAMTOR4 OS=Homo sapiens OX=9606 GN=LAMTOR4 PE=1 SV=1" "0.072" "False" "1.197" "7" "1" "1" "1" "99" "10.7" "6.54" "2.08" "1" "cell organization and biogenesis;signal transduction;other biological processes" "other membranes;other cytoplasmic organelle;other cell component" "" "" "389541" "ENSG00000188186" "LAMTOR4" "hsa:389541; Q0VGL1" "" "Amino acids regulate mTORC1; Regulation of PTEN gene transcription; mTORC1-mediated signalling; TP53 Regulates Metabolic Genes; Macroautophagy; Energy dependent regulation of mTOR by LKB1-AMPK" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5823057819559300912" "False" "Low" "IsMasterProtein" "O15230" "Laminin subunit alpha-5 OS=Homo sapiens OX=9606 GN=LAMA5 PE=1 SV=8" "0.072" "False" "1.197" "0" "1" "1" "1" "3695" "399.5" "7.02" "2.85" "1" "cell adhesion;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "non-structural extracellular;extracellular matrix;other cell component" "signal transduction activity or receptor binding" "Pf00052, Pf00053, Pf00054, Pf00055, Pf02210, Pf06008, Pf06009" "3911" "ENSG00000130702" "LAMA5" "hsa:3911; O15230; Q5U4N9; Q8TDF8; Q8WZA7; Q9H1P1" "Alpha 6 beta 4 signaling pathway; Primary focal segmental glomerulosclerosis (FSGS); Complement system; Focal adhesion; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; PI3K-Akt signaling pathway; Inflammatory response pathway; Small cell lung cancer; Pleural mesothelioma" "Degradation of the extracellular matrix; ECM proteoglycans; Non-integrin membrane-ECM interactions; Interleukin-4 and Interleukin-13 signaling; Laminin interactions; MET activates PTK2 signaling" "15" "0" "0.969" "1.022" "0.853" "1.030" "1.016" "0.982" "1.016" "0.984" "0.870" "118.4" "114.7" "121.0" "101.0" "122.0" "120.3" "116.2" "120.3" "116.4" "103.0" "" "" "" "" "" "" "" "" "" "" "106.4" "92.8" "109.5" "98.6" "100.6" "120.3" "87.0" "106.3" "104.2" "36.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4179589302645332535" "False" "Low" "IsMasterProtein" "Q96LK8" "Spermatogenesis-associated protein 32 OS=Homo sapiens OX=9606 GN=SPATA32 PE=1 SV=3" "0.072" "False" "1.196" "3" "1" "1" "1" "384" "42.3" "4.77" "0.00" "1" "other biological processes" "other cell component" "cytoskeletal activity" "Pf15310" "124783" "ENSG00000184361" "SPATA32" "hsa:124783; Q7Z4U1; Q8N6V6; Q96LK8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5925761923209875400" "False" "Low" "IsMasterProtein" "Q12824" "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Homo sapiens OX=9606 GN=SMARCB1 PE=1 SV=2" "0.072" "False" "1.194" "2" "1" "2" "1" "385" "44.1" "6.23" "4.85" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf04855, Pf21459" "6598" "ENSG00000099956; ENSG00000275837" "SMARCB1" "hsa:6598; O75784; O95474; Q12824; Q17S11; Q38GA1; Q76N08; Q9UBH2" "Tumor suppressor activity of SMARCB1; Thermogenesis; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; Kleefstra syndrome; 10q11.21q11.23 copy number variation syndrome" "RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known; RMTs methylate histone arginines" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-4882182071809398936" "False" "Low" "IsMasterProtein" "P55289" "Cadherin-12 OS=Homo sapiens OX=9606 GN=CDH12 PE=1 SV=2" "0.072" "False" "1.194" "1" "1" "1" "1" "794" "88.3" "4.81" "0.00" "1" "cell adhesion;cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;other cell component" "other molecular function" "Pf00028, Pf01049" "1010" "ENSG00000154162" "CDH12" "B2RBT1; B7Z2U6; hsa:1010; P55289; Q86UD2" "Hippo signaling regulation pathways; Hippo-Merlin signaling dysregulation; Pleural mesothelioma" "Adherens junctions interactions" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-863979425493659150" "False" "Low" "IsMasterProtein" "Q8TBH0" "Arrestin domain-containing protein 2 OS=Homo sapiens OX=9606 GN=ARRDC2 PE=1 SV=2" "0.072" "False" "1.189" "2" "1" "1" "1" "407" "44.4" "9.20" "0.00" "1" "transport" "plasma membrane;other membranes;other cell component" "" "Pf00339, Pf02752" "27106" "ENSG00000105643" "ARRDC2" "B2RBG9; hsa:27106; O95895; Q6ZRV9; Q8TBH0; Q8WYG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7791806477586966381" "False" "Low" "IsMasterProtein" "O00481" "Butyrophilin subfamily 3 member A1 OS=Homo sapiens OX=9606 GN=BTN3A1 PE=1 SV=3" "0.072" "False" "1.189" "1" "1" "1" "1" "513" "57.6" "8.03" "0.00" "1" "cell cycle OR cell proliferation;signal transduction;other biological processes" "plasma membrane;other membranes" "signal transduction activity or receptor binding" "Pf00622, Pf07686, Pf13765" "11119" "ENSG00000026950" "BTN3A1" "A2A278; A8K2C8; B4DIQ1; B4DRM2; E9PGB4; E9PHG8; hsa:11119; O00481; Q0P515; Q147X5; Q53F15; Q99420; Q9HCY1" "" "Butyrophilin (BTN) family interactions" "1" "0" "1.070" "0.986" "1.042" "0.963" "1.067" "1.105" "0.946" "1.226" "0.813" "229.6" "245.7" "226.5" "239.4" "221.2" "245.1" "253.7" "217.3" "281.6" "186.7" "" "" "" "" "" "" "" "" "" "" "206.5" "198.8" "204.8" "233.6" "182.6" "245.1" "190.0" "192.0" "252.0" "66.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1638288113087067454" "False" "Low" "IsMasterProtein" "Q9NQG6" "Mitochondrial dynamics protein MIEF1 OS=Homo sapiens OX=9606 GN=MIEF1 PE=1 SV=1" "0.072" "False" "1.187" "2" "1" "1" "1" "463" "51.3" "7.64" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf20266, Pf21297" "54471" "ENSG00000100335" "MIEF1" "hsa:54471; Q7L890; Q9BUI3; Q9NQG6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2459331660579063458" "False" "Low" "IsMasterProtein" "Q9UG56" "Phosphatidylserine decarboxylase proenzyme, mitochondrial OS=Homo sapiens OX=9606 GN=PISD PE=1 SV=4" "0.072" "False" "1.186" "2" "1" "1" "1" "409" "46.6" "9.42" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf02666" "23761" "ENSG00000241878" "PISD" "B1AKM7; hsa:23761; O43207; O95535; Q6IC28; Q96GQ2; Q9UG56; Q9UGA9" "Kennedy pathway from sphingolipids; Glycerolipids and glycerophospholipids" "Synthesis of PE" "3" "0" "0.902" "0.925" "0.944" "0.922" "0.963" "0.889" "0.956" "0.987" "0.805" "161.3" "145.4" "149.1" "152.1" "148.7" "155.3" "143.4" "154.1" "159.2" "129.8" "" "" "" "" "" "" "" "" "" "" "145.0" "117.6" "134.9" "148.5" "122.7" "155.3" "107.4" "136.1" "142.5" "46.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8071757354241152086" "False" "Low" "IsMasterProtein" "P47989" "Xanthine dehydrogenase/oxidase OS=Homo sapiens OX=9606 GN=XDH PE=1 SV=4" "0.073" "False" "1.186" "1" "1" "1" "1" "1333" "146.3" "7.66" "1.74" "1" "cell organization and biogenesis;other metabolic processes;transport;other biological processes" "cytosol;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf00111, Pf00941, Pf01315, Pf01799, Pf02738, Pf03450, Pf20256" "7498" "ENSG00000158125" "XDH" "hsa:7498; P47989; Q16681; Q16712; Q4PJ16" "Selenium micronutrient network; Effects of nitric oxide; Caffeine and theobromine metabolism; Oxidative stress response" "Butyrophilin (BTN) family interactions; Azathioprine ADME; Purine catabolism" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "200614731296740673" "False" "Low" "IsMasterProtein" "Q8IU68" "Transmembrane channel-like protein 8 OS=Homo sapiens OX=9606 GN=TMC8 PE=1 SV=1" "0.073" "False" "1.185" "2" "1" "1" "1" "726" "81.6" "9.36" "0.00" "1" "transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;nucleus;other cell component" "transporter activity;other molecular function" "Pf07810" "147138" "ENSG00000167895" "TMC8" "hsa:147138; Q2YDC0; Q8IU68; Q8IWU7; Q8N358; Q8NF04" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "8885085166305276331" "False" "Low" "IsMasterProtein" "Q9BUU2" "Methyltransferase-like protein 22 OS=Homo sapiens OX=9606 GN=METTL22 PE=1 SV=2" "0.073" "False" "1.184" "3" "1" "1" "1" "404" "44.5" "5.07" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes" "nucleus;other cell component" "other molecular function" "Pf10294" "79091" "ENSG00000067365" "METTL22" "B2RD29; D3DUF2; hsa:79091; Q6XYB4; Q9BUU2; Q9HA03" "" "Protein methylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3677391280234364065" "False" "Low" "IsMasterProtein" "Q14993" "Collagen alpha-1(XIX) chain OS=Homo sapiens OX=9606 GN=COL19A1 PE=1 SV=3" "0.073" "False" "1.183" "1" "1" "1" "1" "1142" "115.1" "8.32" "0.00" "1" "cell adhesion;cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "extracellular structural activity;other molecular function" "Pf01391" "1310" "ENSG00000082293" "COL19A1" "hsa:1310; Q00559; Q05850; Q12885; Q13676; Q14993; Q14DH1; Q5JUF0; Q5T424; Q9H572; Q9NPZ2; Q9NQP2" "" "Collagen degradation; Collagen chain trimerization" "3" "0" "0.991" "0.976" "0.883" "1.105" "0.823" "1.123" "0.978" "0.822" "1.145" "49.0" "48.5" "47.8" "43.3" "54.2" "40.3" "55.0" "47.9" "40.3" "56.1" "" "" "" "" "" "" "" "" "" "" "44.1" "39.3" "43.2" "42.2" "44.7" "40.3" "41.2" "42.3" "36.0" "20.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "876115928982754265" "False" "Low" "IsMasterProtein" "P00519" "Tyrosine-protein kinase ABL1 OS=Homo sapiens OX=9606 GN=ABL1 PE=1 SV=4" "0.073" "False" "1.183" "1" "1" "1" "1" "1130" "122.8" "8.66" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "other membranes;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "signal transduction activity or receptor binding;cytoskeletal activity;nucleic acid binding activity;kinase activity;other molecular function" "Pf00017, Pf00018, Pf07714, Pf08919" "25" "ENSG00000097007" "ABL1" "A3KFJ3; hsa:25; P00519; Q13869; Q13870; Q16133; Q17R61; Q45F09" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; TP53 network; Cell cycle; Microtubule cytoskeleton regulation; Pathogenic Escherichia coli infection; Retinoblastoma gene in cancer; ATM signaling pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Imatinib and chronic myeloid leukemia; VEGFA-VEGFR2 signaling; Ras signaling; Acute viral myocarditis; EGF/EGFR signaling pathway; Macrophage-stimulating protein (MSP) signaling network map; 5q35 copy number variation; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Regulation of actin dynamics for phagocytic cup formation; FCGR3A-mediated phagocytosis; RUNX1 regulates transcription of genes involved in differentiation of HSCs; RHO GTPases Activate WASPs and WAVEs; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks; Myogenesis; Cyclin D associated events in G1; Factors involved in megakaryocyte development and platelet production; RUNX2 regulates osteoblast differentiation; HDR through Single Strand Annealing (SSA); Role of ABL in ROBO-SLIT signaling" "30" "0" "0.943" "1.142" "1.417" "0.994" "1.156" "1.377" "1.687" "0.747" "1.774" "19.4" "18.3" "22.1" "27.5" "19.3" "22.4" "26.7" "32.7" "14.5" "34.4" "" "" "" "" "" "" "" "" "" "" "17.4" "14.8" "20.0" "26.8" "15.9" "22.4" "20.0" "28.9" "13.0" "12.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4124929947766607095" "False" "Low" "IsMasterProtein" "Q9UK58" "Cyclin-L1 OS=Homo sapiens OX=9606 GN=CCNL1 PE=1 SV=1" "0.073" "False" "1.182" "1" "1" "1" "1" "526" "59.6" "10.70" "2.07" "1" "other biological processes" "nucleus;other cell component" "enzyme regulator activity" "Pf00134, Pf02984" "57018" "ENSG00000163660" "CCNL1" "B3KMY3; C9JPL0; hsa:57018; Q6NVY9; Q6UWS7; Q8NI48; Q96QT0; Q9NZF3; Q9UK58" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8700335326144916466" "False" "Low" "IsMasterProtein" "Q9UET6" "tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase OS=Homo sapiens OX=9606 GN=FTSJ1 PE=1 SV=2" "0.073" "False" "1.181" "3" "1" "1" "1" "329" "36.1" "5.69" "0.00" "1" "protein metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf01728" "24140" "ENSG00000068438" "FTSJ1" "B2RCJ0; hsa:24140; O75670; Q9UET6" "" "tRNA modification in the nucleus and cytosol" "1" "0" "1.012" "0.881" "0.965" "0.980" "1.039" "0.975" "0.888" "0.920" "1.032" "125.2" "126.7" "110.3" "120.7" "122.6" "130.0" "122.0" "111.1" "115.2" "129.2" "" "" "" "" "" "" "" "" "" "" "112.5" "102.5" "99.7" "117.8" "101.2" "130.0" "91.3" "98.1" "103.1" "46.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8568977254648879240" "False" "Low" "IsMasterProtein" "P56715" "Oxygen-regulated protein 1 OS=Homo sapiens OX=9606 GN=RP1 PE=1 SV=1" "0.073" "False" "1.180" "0" "1" "1" "1" "2156" "240.5" "5.80" "2.02" "1" "cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "cytoskeletal activity" "Pf03607" "6101" "ENSG00000104237" "RP1" "hsa:6101; P56715" "Ciliopathies" "" "1" "0" "1.455" "0.977" "0.597" "1.740" "1.178" "1.964" "1.366" "1.237" "0.822" "97.3" "141.5" "95.0" "58.0" "169.2" "114.6" "191.0" "132.8" "120.3" "80.0" "" "" "" "" "" "" "" "" "" "" "87.5" "114.5" "85.9" "56.7" "139.7" "114.6" "143.1" "117.3" "107.6" "28.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3599368331442673312" "False" "Low" "IsMasterProtein" "Q8WWY8" "Lipase member H OS=Homo sapiens OX=9606 GN=LIPH PE=1 SV=1" "0.074" "False" "1.179" "4" "1" "1" "1" "451" "50.8" "7.42" "2.12" "1" "other metabolic processes" "non-structural extracellular;plasma membrane;other membranes" "other molecular function" "Pf00151" "200879" "ENSG00000163898" "LIPH" "A2IBA7; hsa:200879; Q8TEC7; Q8WWY8" "" "Synthesis of PA" "1" "0" "0.994" "1.016" "0.994" "1.120" "1.136" "0.942" "1.019" "1.088" "1.065" "141.6" "140.8" "143.9" "140.8" "158.6" "160.8" "133.4" "144.3" "154.0" "150.8" "" "" "" "" "" "" "" "" "" "" "127.3" "113.9" "130.1" "137.4" "130.9" "160.8" "99.9" "127.5" "137.8" "53.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1834227978876737947" "False" "Low" "IsMasterProtein" "Q96EP1" "E3 ubiquitin-protein ligase CHFR OS=Homo sapiens OX=9606 GN=CHFR PE=1 SV=2" "0.074" "False" "1.177" "2" "1" "1" "1" "664" "73.3" "6.04" "0.00" "1" "cell cycle OR cell proliferation;protein metabolism;other metabolic processes;signal transduction;other biological processes" "nucleus" "other molecular function" "Pf00498, Pf13923, Pf17979" "55743" "ENSG00000072609" "CHFR" "A6NEN5; B4DZ77; B4E2L6; hsa:55743; Q96EP1; Q96SL3; Q9NRT4; Q9NT32; Q9NVD5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5139072581549819915" "False" "Low" "IsMasterProtein" "Q8IWV8" "E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens OX=9606 GN=UBR2 PE=1 SV=1" "0.074" "False" "1.177" "1" "1" "1" "1" "1755" "200.4" "6.24" "2.66" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf02207, Pf02617, Pf18995" "23304" "ENSG00000024048" "UBR2" "O15057; Q4VXK2; Q5TFH6; Q6P2I2; Q6ZUD0; Q8IWV8" "Male infertility; Primary ovarian insufficiency" "Antigen processing: Ubiquitination & Proteasome degradation" "3" "0" "0.878" "0.707" "1.888" "0.956" "1.347" "1.160" "1.571" "1.132" "0.900" "129.5" "113.7" "91.5" "244.5" "123.8" "174.5" "150.2" "203.4" "146.6" "116.6" "" "" "" "" "" "" "" "" "" "" "116.5" "92.0" "82.8" "238.7" "102.2" "174.5" "112.5" "179.7" "131.2" "41.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6995869173039839710" "False" "Low" "IsMasterProtein" "P19099" "Cytochrome P450 11B2, mitochondrial OS=Homo sapiens OX=9606 GN=CYP11B2 PE=1 SV=3" "0.075" "False" "1.173" "2" "1" "2" "1" "503" "57.5" "9.39" "4.19" "1" "other metabolic processes;other biological processes" "other membranes;mitochondrion" "other molecular function" "Pf00067" "1585" "ENSG00000179142" "CYP11B2" "B0ZBE4; hsa:1585; P19099; Q16726" "Oxidation by cytochrome P450; Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism; Nephrotic syndrome; FGF23 signaling in hypophosphatemic rickets and related disorders; Orexin receptor pathway; ACE inhibitor pathway; Metapathway biotransformation Phase I and II" "Endogenous sterols; Glucocorticoid biosynthesis; Mineralocorticoid biosynthesis; Defective CYP11B2 causes CMO-1 deficiency" "11" "0" "0.842" "0.983" "0.895" "0.984" "0.849" "0.815" "0.840" "0.912" "0.727" "198.9" "167.6" "195.5" "178.0" "195.7" "168.8" "162.1" "167.2" "181.4" "144.6" "" "" "" "" "" "" "" "" "" "" "178.8" "135.6" "176.9" "173.7" "161.5" "168.8" "121.3" "147.7" "162.4" "51.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2459837827147389538" "False" "Low" "IsMasterProtein" "A6NCW0" "Ubiquitin carboxyl-terminal hydrolase 17-like protein 3 OS=Homo sapiens OX=9606 GN=USP17L3 PE=3 SV=1" "0.075" "False" "1.173" "3" "1" "1" "1" "530" "59.5" "7.74" "2.78" "1" "protein metabolism;other biological processes" "cytosol;ER/Golgi;nucleus" "other molecular function" "Pf00443" "645836" "ENSG00000225327" "USP17L3" "A6NCW0; hsa:645836" "" "Ub-specific processing proteases" "1" "0" "0.897" "1.047" "0.734" "0.810" "0.857" "0.606" "0.753" "0.861" "0.708" "262.6" "235.5" "274.9" "192.8" "212.6" "225.0" "159.2" "197.8" "226.1" "185.8" "" "" "" "" "" "" "" "" "" "" "236.1" "190.5" "248.6" "188.2" "175.5" "225.0" "119.2" "174.7" "202.3" "66.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8470537921174600195" "False" "Low" "IsMasterProtein" "Q9NZM1" "Myoferlin OS=Homo sapiens OX=9606 GN=MYOF PE=1 SV=1" "0.075" "False" "1.172" "1" "1" "1" "1" "2061" "234.6" "6.18" "0.00" "1" "cell organization and biogenesis;stress response;other biological processes" "plasma membrane;other membranes;cytoskeleton;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00168, Pf08150, Pf08151, Pf08165, Pf16165" "26509" "ENSG00000138119" "MYOF" "B3KQN5; hsa:26509; Q5VWW2; Q5VWW3; Q5VWW4; Q5VWW5; Q7Z642; Q8IWH0; Q9HBU3; Q9NZM0; Q9NZM1; Q9ULL3; Q9Y4U4" "Aryl hydrocarbon receptor pathway; Nuclear receptors meta-pathway; Hepatitis C and hepatocellular carcinoma" "" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6195268452072663269" "False" "Low" "IsMasterProtein" "P40189" "Interleukin-6 receptor subunit beta OS=Homo sapiens OX=9606 GN=IL6ST PE=1 SV=2" "0.075" "False" "1.171" "1" "1" "1" "1" "918" "103.5" "5.95" "0.00" "1" "other metabolic processes;developmental processes;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes;other cell component" "signal transduction activity or receptor binding;enzyme regulator activity;other molecular function" "Pf00041, Pf06328, Pf09240" "3572" "ENSG00000134352" "IL6ST" "A0N0L4; hsa:3572; P40189; Q5FC04; Q9UQ41" "Physiological and pathological hypertrophy of the heart; MicroRNAs in cardiomyocyte hypertrophy; Interleukin-11 signaling pathway; Adipogenesis; Oncostatin M signaling pathway; Mammary gland development pathway - Involution (Stage 4 of 4); IL6 signaling pathway; Embryonic stem cell pluripotency pathways; ncRNAs involved in STAT3 signaling in hepatocellular carcinoma; Genes associated with the development of rheumatoid arthritis; Angiotensin II receptor type 1 pathway; Neuroinflammation and glutamatergic signaling" "Interleukin-6 signaling; IL-6-type cytokine receptor ligand interactions; Interleukin-35 Signalling; Interleukin-27 signaling" "16" "0" "0.954" "1.026" "1.033" "1.035" "0.892" "1.048" "1.064" "0.978" "0.836" "186.8" "178.3" "191.7" "193.0" "193.3" "166.6" "195.8" "198.7" "182.7" "156.3" "" "" "" "" "" "" "" "" "" "" "168.0" "144.2" "173.4" "188.4" "159.5" "166.6" "146.6" "175.5" "163.5" "55.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "29627463948576905" "False" "Low" "IsMasterProtein" "Q9NUQ8" "ATP-binding cassette sub-family F member 3 OS=Homo sapiens OX=9606 GN=ABCF3 PE=1 SV=2" "0.075" "False" "1.167" "1" "1" "1" "1" "709" "79.7" "6.34" "2.89" "1" "stress response" "" "other molecular function" "Pf00005, Pf12848" "55324" "ENSG00000161204" "ABCF3" "A8K241; hsa:55324; Q86UA2; Q8NAN1; Q96GS8; Q9H7A8; Q9NUQ8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6346286157206717868" "False" "Low" "IsMasterProtein" "Q8IVV2" "Lipoxygenase homology domain-containing protein 1 OS=Homo sapiens OX=9606 GN=LOXHD1 PE=2 SV=4" "0.075" "False" "1.166" "0" "1" "1" "1" "2067" "235.5" "5.57" "2.46" "1" "other biological processes" "other cell component" "" "Pf01477" "125336" "ENSG00000167210" "LOXHD1" "B7WNN3; B7WNT1; B7WPI9; H7BZ41; hsa:125336; Q6ZRY7; Q86WW9; Q8IVV2; Q96DL7" "" "" "0" "0" "1.066" "0.914" "0.994" "1.099" "0.957" "1.018" "0.987" "0.904" "1.044" "113.4" "121.0" "103.7" "112.8" "124.7" "108.6" "115.4" "112.0" "102.5" "118.5" "" "" "" "" "" "" "" "" "" "" "102.0" "97.9" "93.8" "110.1" "102.9" "108.6" "86.4" "98.9" "91.7" "42.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2379672404841283582" "False" "Low" "IsMasterProtein" "Q2VIQ3" "Chromosome-associated kinesin KIF4B OS=Homo sapiens OX=9606 GN=KIF4B PE=1 SV=2" "0.075" "False" "1.165" "1" "1" "1" "1" "1234" "139.9" "6.18" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton;nucleus" "cytoskeletal activity;nucleic acid binding activity;other molecular function" "Pf00225" "285643" "ENSG00000226650" "KIF4B" "hsa:285643; Q2VIQ3" "" "COPI-dependent Golgi-to-ER retrograde traffic; MHC class II antigen presentation; Recycling pathway of L1; Kinesins" "4" "0" "1.042" "0.999" "1.187" "1.416" "1.045" "1.384" "1.198" "1.252" "1.098" "31.9" "33.3" "31.9" "37.9" "45.2" "33.4" "44.2" "38.3" "40.0" "35.1" "" "" "" "" "" "" "" "" "" "" "28.7" "26.9" "28.9" "37.0" "37.3" "33.4" "33.1" "33.8" "35.8" "12.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5145087697178070665" "False" "Low" "IsMasterProtein" "Q9H4I2" "Zinc fingers and homeoboxes protein 3 OS=Homo sapiens OX=9606 GN=ZHX3 PE=1 SV=3" "0.076" "False" "1.164" "2" "1" "1" "1" "956" "104.6" "6.07" "1.78" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00046, Pf11569, Pf18387" "23051" "ENSG00000174306" "ZHX3" "E1P5W5; F5H820; hsa:23051; O43145; Q6NUJ7; Q9H4I2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5793129811355611402" "False" "Low" "IsMasterProtein" "Q6XUX3" "Dual serine/threonine and tyrosine protein kinase OS=Homo sapiens OX=9606 GN=DSTYK PE=1 SV=2" "0.076" "False" "1.163" "1" "1" "1" "1" "929" "105.1" "6.74" "3.01" "1" "other metabolic processes;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf00069" "25778" "ENSG00000133059" "DSTYK" "B7ZL64; hsa:25778; O75060; Q17R94; Q5RKT0; Q6IN87; Q6P997; Q6XUX3; Q86Y03; Q9P1S5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1730131359197889533" "False" "Low" "IsMasterProtein" "Q8IVU3" "Probable E3 ubiquitin-protein ligase HERC6 OS=Homo sapiens OX=9606 GN=HERC6 PE=1 SV=2" "0.076" "False" "1.160" "1" "1" "1" "1" "1022" "115.1" "7.96" "2.47" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00415, Pf00632, Pf13540" "55008" "ENSG00000138642" "HERC6" "B4DIY5; hsa:55008; Q5GC90; Q5GRH3; Q5HYM6; Q5JPB6; Q6PIF4; Q8IVU3; Q8NAN3; Q9NWS4" "" "Antigen processing: Ubiquitination & Proteasome degradation" "1" "0" "0.896" "1.339" "1.008" "1.185" "1.250" "1.127" "1.091" "1.483" "0.987" "151.9" "136.1" "203.4" "153.0" "179.9" "189.9" "171.1" "165.8" "225.2" "149.9" "" "" "" "" "" "" "" "" "" "" "136.5" "110.1" "184.0" "149.4" "148.5" "189.9" "128.1" "146.4" "201.5" "53.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6157153298590242054" "False" "Low" "IsMasterProtein" "Q8IZQ5" "Selenoprotein H OS=Homo sapiens OX=9606 GN=SELENOH PE=1 SV=2" "0.077" "False" "1.158" "7" "1" "1" "1" "122" "13.4" "9.74" "1.60" "1" "" "ER/Golgi" "" "Pf10262" "280636" "ENSG00000211450" "SELENOH" "hsa:280636; Q8IZQ5; Q8N672" "Selenium micronutrient network; Selenium metabolism and selenoproteins" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3567158229513091577" "False" "Low" "IsMasterProtein" "Q8NDX1" "PH and SEC7 domain-containing protein 4 OS=Homo sapiens OX=9606 GN=PSD4 PE=1 SV=2" "0.077" "False" "1.156" "2" "1" "1" "1" "1056" "116.2" "5.48" "2.18" "1" "other biological processes" "plasma membrane;other membranes" "enzyme regulator activity;other molecular function" "Pf01369, Pf15410" "23550" "ENSG00000125637" "PSD4" "A6NEG7; A8K1Y0; hsa:23550; O95621; Q4ZG34; Q6GPH8; Q8IYP4; Q8NDX1" "2q13 copy number variation syndrome" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3279356034599558921" "False" "Low" "IsMasterProtein" "Q9P0V3" "SH3 domain-binding protein 4 OS=Homo sapiens OX=9606 GN=SH3BP4 PE=1 SV=1" "0.077" "False" "1.150" "1" "1" "1" "1" "963" "107.4" "7.71" "0.00" "1" "transport;other biological processes" "other membranes;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00018, Pf00791, Pf07653" "23677" "ENSG00000130147" "SH3BP4" "hsa:23677; O95082; Q309A3; Q53QD0; Q53TD1; Q9P0V3" "2q37 copy number variation syndrome" "Amino acids regulate mTORC1" "2" "0" "1.099" "1.027" "0.980" "0.955" "0.801" "0.918" "0.869" "0.951" "0.630" "114.3" "125.5" "117.3" "112.0" "109.1" "91.6" "105.0" "99.3" "108.7" "72.0" "" "" "" "" "" "" "" "" "" "" "102.8" "101.6" "106.1" "109.4" "90.0" "91.6" "78.6" "87.7" "97.3" "25.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7256809200695467141" "False" "Low" "IsMasterProtein" "Q02083" "N-acylethanolamine-hydrolyzing acid amidase OS=Homo sapiens OX=9606 GN=NAAA PE=1 SV=3" "0.078" "False" "1.146" "2" "1" "1" "1" "359" "40.0" "8.75" "1.99" "1" "other metabolic processes" "other membranes;other cytoplasmic organelle;other cell component" "other molecular function" "Pf02275, Pf15508" "27163" "ENSG00000138744" "NAAA" "hsa:27163; Q02083; Q5KTF2; Q96EY2; Q9BRA8" "" "Neurotransmitter release cycle" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4762108780726975250" "False" "Low" "IsMasterProtein" "O60861" "Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3" "0.079" "False" "1.144" "2" "1" "1" "1" "476" "54.3" "7.34" "1.69" "1" "cell organization and biogenesis;developmental processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00397, Pf00611, Pf14604, Pf16623" "8522" "ENSG00000007237" "GAS7" "A8KAC2; B2RCK9; hsa:8522; O43144; O60861; Q53Y77; Q7Z571" "" "" "0" "0" "1.028" "0.920" "0.470" "1.073" "1.113" "1.152" "0.743" "0.701" "0.999" "60.8" "62.5" "55.9" "28.6" "65.2" "67.6" "70.0" "45.2" "42.6" "60.7" "" "" "" "" "" "" "" "" "" "" "54.6" "50.6" "50.6" "27.9" "53.8" "67.6" "52.4" "39.9" "38.1" "21.7" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7800282682775508248" "False" "Low" "IsMasterProtein" "Q9H819" "DnaJ homolog subfamily C member 18 OS=Homo sapiens OX=9606 GN=DNAJC18 PE=1 SV=1" "0.079" "False" "1.141" "2" "1" "1" "1" "358" "41.5" "7.37" "2.64" "1" "protein metabolism;other metabolic processes;stress response" "other membranes;ER/Golgi" "other molecular function" "Pf00226, Pf09320" "202052" "ENSG00000170464" "DNAJC18" "hsa:202052; Q9H819" "" "" "0" "0" "0.953" "0.816" "1.022" "0.943" "0.859" "1.028" "0.922" "0.874" "1.111" "190.3" "181.4" "155.3" "194.5" "179.5" "163.4" "195.6" "175.4" "166.2" "211.3" "" "" "" "" "" "" "" "" "" "" "171.1" "146.8" "140.5" "189.9" "148.1" "163.4" "146.5" "154.9" "148.7" "75.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1030026075481610676" "False" "Low" "IsMasterProtein" "Q8N4N3" "Kelch-like protein 36 OS=Homo sapiens OX=9606 GN=KLHL36 PE=1 SV=1" "0.079" "False" "1.141" "1" "1" "1" "1" "616" "69.9" "6.24" "2.25" "1" "protein metabolism;other metabolic processes" "" "other molecular function" "Pf00651, Pf01344, Pf07707" "79786" "ENSG00000135686" "KLHL36" "hsa:79786; Q8N4N3; Q8N5G6; Q9H9U6" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9124413372325642778" "False" "Low" "IsMasterProtein" "P12757" "Ski-like protein OS=Homo sapiens OX=9606 GN=SKIL PE=1 SV=2" "0.080" "False" "1.137" "1" "1" "1" "1" "684" "76.9" "7.11" "2.39" "1" "stress response;developmental processes;signal transduction;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf02437, Pf08782" "6498" "ENSG00000136603" "SKIL" "A6NGT1; B4DT50; hsa:6498; O00464; P12756; P12757; Q07501" "Ectoderm differentiation; Lung fibrosis; TGF-beta signaling pathway; Transcription co-factors SKI and SKIL protein partners; TGF-beta receptor signaling in skeletal dysplasias; Orexin receptor pathway; TGF-beta receptor signaling" "Downregulation of SMAD2/3:SMAD4 transcriptional activity" "8" "0" "1.078" "1.161" "0.939" "1.073" "1.023" "1.011" "1.025" "1.007" "1.181" "262.7" "283.3" "304.9" "246.8" "282.0" "268.8" "265.6" "269.2" "264.6" "310.3" "" "" "" "" "" "" "" "" "" "" "236.2" "229.2" "275.8" "240.9" "232.7" "268.8" "198.9" "237.8" "236.8" "110.8" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7518905960528906549" "False" "Low" "IsMasterProtein" "P13942" "Collagen alpha-2(XI) chain OS=Homo sapiens OX=9606 GN=COL11A2 PE=1 SV=5" "0.080" "False" "1.135" "1" "1" "1" "1" "1736" "171.7" "6.21" "0.00" "1" "cell organization and biogenesis;developmental processes;other biological processes" "non-structural extracellular;extracellular matrix;ER/Golgi;other cell component" "other molecular function" "Pf01391, Pf01410, Pf02210" "1302" "ENSG00000204248; ENSG00000206290; ENSG00000227801; ENSG00000230930; ENSG00000235708" "COL11A2" "A6NLX2; E7ER90; hsa:1302; P13942; Q07751; Q13271; Q13272; Q13273; Q5JP94; Q5SUI8; Q7Z6C3; Q99866; Q9UIP9" "Neural crest differentiation; Focal adhesion: PI3K-Akt-mTOR-signaling pathway" "Collagen degradation; Assembly of collagen fibrils and other multimeric structures; Collagen chain trimerization; Non-integrin membrane-ECM interactions; MET activates PTK2 signaling" "8" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3783128297487644" "False" "Low" "IsMasterProtein" "Q96DT5" "Dynein axonemal heavy chain 11 OS=Homo sapiens OX=9606 GN=DNAH11 PE=1 SV=4" "0.080" "False" "1.135" "0" "1" "1" "1" "4516" "520.0" "6.44" "0.00" "1" "transport;developmental processes;other biological processes" "non-structural extracellular;cytoskeleton" "cytoskeletal activity;other molecular function" "Pf03028, Pf08385, Pf08393, Pf12774, Pf12775, Pf12777, Pf12780, Pf12781, Pf17852, Pf17857, Pf18198, Pf18199" "8701" "ENSG00000105877" "DNAH11" "hsa:8701; Q96DT5; Q9UJ82" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2381858661895585600" "False" "Low" "IsMasterProtein" "Q9C0K0" "B-cell lymphoma/leukemia 11B OS=Homo sapiens OX=9606 GN=BCL11B PE=1 SV=1" "0.080" "False" "1.135" "1" "1" "1" "1" "894" "95.5" "6.55" "2.17" "1" "cell organization and biogenesis;DNA metabolism;RNA metabolism OR transcription;other metabolic processes;developmental processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "64919" "ENSG00000127152" "BCL11B" "hsa:64919; Q9C0K0; Q9H162" "Development and heterogeneity of the ILC family" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1474010075378452952" "False" "Low" "IsMasterProtein" "P15924" "Desmoplakin OS=Homo sapiens OX=9606 GN=DSP PE=1 SV=3" "0.080" "False" "1.133" "0" "1" "1" "1" "2871" "331.6" "6.81" "1.85" "1" "cell adhesion;cell organization and biogenesis;protein metabolism;other metabolic processes;stress response;developmental processes;other biological processes" "plasma membrane;other membranes;cytoskeleton;other cell component" "cytoskeletal activity;other molecular function" "Pf00681, Pf17902, Pf18373, Pf21019" "1832" "ENSG00000096696" "DSP" "B2RTT2; D7RX09; hsa:1832; O75993; P15924; Q14189; Q9UHN4" "Arrhythmogenic right ventricular cardiomyopathy; Lung fibrosis; Epithelial to mesenchymal transition in colorectal cancer" "Formation of the cornified envelope; Neutrophil degranulation; RND3 GTPase cycle; RND1 GTPase cycle; Apoptotic cleavage of cell adhesion proteins" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5586523192693174364" "False" "Low" "IsMasterProtein" "Q68CR1" "Protein sel-1 homolog 3 OS=Homo sapiens OX=9606 GN=SEL1L3 PE=1 SV=2" "0.080" "False" "1.133" "2" "1" "1" "1" "1132" "128.5" "7.28" "2.58" "1" "" "other membranes" "" "Pf08238" "23231" "ENSG00000091490" "SEL1L3" "A0PJH6; A8K0X2; hsa:23231; O94847; Q68CR1; Q6P999; Q96G59" "" "" "0" "0" "0.966" "0.976" "0.891" "1.271" "0.833" "0.996" "0.998" "1.029" "0.865" "56.7" "54.8" "55.3" "50.5" "72.1" "47.3" "56.5" "56.6" "58.4" "49.1" "" "" "" "" "" "" "" "" "" "" "51.0" "44.4" "50.1" "49.3" "59.5" "47.3" "42.3" "50.0" "52.2" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4171853106673834253" "False" "Low" "IsMasterProtein" "Q9BVV6" "Protein TALPID3 OS=Homo sapiens OX=9606 GN=KIAA0586 PE=1 SV=4" "0.080" "False" "1.132" "0" "1" "1" "1" "1533" "169.2" "5.54" "2.09" "1" "cell organization and biogenesis;signal transduction;other biological processes" "cytoskeleton;other cell component" "" "Pf15324" "9786" "ENSG00000100578" "KIAA0586" "B4DZB6; E7EWM8; hsa:9786; J3KQH9; O60328; Q6NYC6; Q6UV20; Q9BVV6" "Joubert syndrome; Ciliopathies" "" "2" "0" "1.099" "0.992" "0.945" "1.146" "0.894" "1.093" "0.896" "0.977" "0.868" "200.6" "220.4" "198.9" "189.6" "229.9" "179.2" "219.3" "179.8" "195.9" "174.1" "" "" "" "" "" "" "" "" "" "" "180.3" "178.4" "179.9" "185.0" "189.7" "179.2" "164.2" "158.8" "175.3" "62.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-682592126243846298" "False" "Low" "IsMasterProtein" "P61647" "Alpha-2,8-sialyltransferase 8F OS=Homo sapiens OX=9606 GN=ST8SIA6 PE=1 SV=1" "0.080" "False" "1.130" "4" "1" "1" "1" "398" "44.8" "9.06" "0.00" "1" "protein metabolism;other metabolic processes;developmental processes" "other membranes;ER/Golgi" "other molecular function" "Pf00777" "338596" "ENSG00000148488" "ST8SIA6" "B0YJ97; B9EH72; hsa:338596; P61647; Q5VZH4" "" "Sialic acid metabolism; N-Glycan antennae elongation" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1305056283911304524" "False" "Low" "IsMasterProtein" "Q86VW1" "Solute carrier family 22 member 16 OS=Homo sapiens OX=9606 GN=SLC22A16 PE=1 SV=1" "0.080" "False" "1.130" "1" "1" "1" "1" "577" "64.6" "8.15" "1.69" "1" "transport;other biological processes" "plasma membrane;other membranes;cytosol" "transporter activity" "Pf00083" "85413" "ENSG00000004809" "SLC22A16" "hsa:85413; O14567; Q5JXM1; Q86VW1; Q8IUG8; Q8IZD5; Q96M90; Q96RU0" "" "Organic cation transport" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7192865757646021535" "False" "Low" "IsMasterProtein" "Q7Z7G8" "Intermembrane lipid transfer protein VPS13B OS=Homo sapiens OX=9606 GN=VPS13B PE=1 SV=2" "0.080" "False" "1.130" "0" "1" "2" "1" "4022" "448.4" "6.46" "1.64" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "other membranes;ER/Golgi;other cytoplasmic organelle" "other molecular function" "Pf06650, Pf12624, Pf16909" "157680" "ENSG00000132549" "VPS13B" "C9JD30; hsa:157680; Q709C6; Q709C7; Q7Z7G4; Q7Z7G5; Q7Z7G6; Q7Z7G7; Q7Z7G8; Q8NB77; Q9NWV1; Q9Y4E7" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2313523377555804982" "False" "Low" "IsMasterProtein" "P49754" "Vacuolar protein sorting-associated protein 41 homolog OS=Homo sapiens OX=9606 GN=VPS41 PE=1 SV=3" "0.080" "False" "1.130" "1" "1" "1" "1" "854" "98.5" "5.85" "0.00" "1" "cell organization and biogenesis;other metabolic processes;stress response;transport;other biological processes" "other membranes;cytosol;cytoskeleton;ER/Golgi;other cytoplasmic organelle;other cell component" "cytoskeletal activity;other molecular function" "Pf00637" "27072" "ENSG00000006715" "VPS41" "E9PF36; hsa:27072; P49754; Q86TP8; Q99851; Q99852" "Ebola virus infection in host; Network map of SARS-CoV-2 signaling pathway" "SARS-CoV-2 modulates autophagy" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5169786287750735930" "False" "Low" "IsMasterProtein" "Q8N9Z0" "Zinc finger protein 610 OS=Homo sapiens OX=9606 GN=ZNF610 PE=1 SV=2" "0.080" "False" "1.129" "2" "1" "3" "1" "462" "53.5" "9.20" "4.44" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352, Pf13465" "162963" "ENSG00000167554" "ZNF610" "A8K4C3; hsa:162963; Q86YH8; Q8N9Z0; Q8NDS9" "" "Generic Transcription Pathway" "1" "0" "0.932" "0.906" "1.072" "0.825" "0.863" "1.027" "0.971" "1.391" "1.099" "33.1" "30.8" "30.0" "35.4" "27.3" "28.5" "33.9" "32.1" "46.0" "36.3" "" "" "" "" "" "" "" "" "" "" "29.7" "24.9" "27.1" "34.6" "22.5" "28.5" "25.4" "28.4" "41.2" "13.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8225461751203981351" "False" "Low" "IsMasterProtein" "O94933" "SLIT and NTRK-like protein 3 OS=Homo sapiens OX=9606 GN=SLITRK3 PE=1 SV=2" "0.080" "False" "1.129" "3" "1" "1" "1" "977" "108.9" "7.37" "0.00" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;developmental processes;other biological processes" "plasma membrane;other membranes;other cell component" "" "Pf13855" "22865" "ENSG00000121871" "SLITRK3" "hsa:22865; O94933; Q1RMY6" "" "RAC3 GTPase cycle; Receptor-type tyrosine-protein phosphatases" "2" "0" "0.909" "0.989" "0.857" "0.992" "0.745" "0.903" "0.858" "0.765" "1.434" "22.1" "20.1" "21.9" "19.0" "22.0" "16.5" "20.0" "19.0" "16.9" "31.7" "" "" "" "" "" "" "" "" "" "" "19.9" "16.3" "19.8" "18.5" "18.1" "16.5" "14.9" "16.8" "15.1" "11.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-579603406694116788" "False" "Low" "IsMasterProtein" "Q9H0C5" "BTB/POZ domain-containing protein 1 OS=Homo sapiens OX=9606 GN=BTBD1 PE=1 SV=1" "0.081" "False" "1.124" "2" "1" "1" "1" "482" "52.7" "6.10" "2.98" "1" "protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "other molecular function" "Pf00651, Pf07707, Pf08005" "53339" "ENSG00000064726" "BTBD1" "A6NMI8; hsa:53339; Q9BX71; Q9H0C5; Q9NWN4" "15q25 copy number variation" "Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "3" "0" "1.067" "1.166" "1.012" "0.954" "0.995" "0.925" "0.975" "1.097" "1.486" "151.2" "161.3" "176.2" "152.9" "144.2" "150.5" "139.8" "147.4" "165.8" "224.7" "" "" "" "" "" "" "" "" "" "" "135.9" "130.5" "159.4" "149.3" "119.0" "150.5" "104.6" "130.2" "148.4" "80.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6289068944778145356" "False" "Low" "IsMasterProtein" "Q9C000" "NACHT, LRR and PYD domains-containing protein 1 OS=Homo sapiens OX=9606 GN=NLRP1 PE=1 SV=1" "0.081" "False" "1.124" "0" "1" "1" "1" "1473" "165.8" "6.84" "3.07" "1" "cell organization and biogenesis;protein metabolism;stress response;signal transduction;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00560, Pf00619, Pf02758, Pf05729, Pf13516, Pf13553, Pf17776, Pf17779" "22861" "ENSG00000091592" "NLRP1" "E9PE50; I6L9D9; Q9BZZ8; Q9BZZ9; Q9C000; Q9H5Z7; Q9H5Z8; Q9HAV8; Q9UFT4; Q9Y2E0" "Nucleotide-binding oligomerization domain (NOD) pathway; Network map of SARS-CoV-2 signaling pathway" "The NLRP1 inflammasome" "3" "0" "1.176" "1.235" "1.133" "1.278" "1.196" "1.300" "1.352" "1.123" "0.921" "84.0" "98.8" "103.8" "95.2" "107.4" "100.5" "109.2" "113.6" "94.3" "77.4" "" "" "" "" "" "" "" "" "" "" "75.6" "79.9" "93.9" "92.9" "88.6" "100.5" "81.8" "100.3" "84.4" "27.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3535736048491732702" "False" "Low" "IsMasterProtein" "Q9NSD4" "Zinc finger protein 275 OS=Homo sapiens OX=9606 GN=ZNF275 PE=1 SV=2" "0.081" "False" "1.121" "3" "1" "1" "1" "429" "48.4" "9.09" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "" "ENSG00000063587" "ZNF275" "A6NE92; Q9NSD4" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "-4274550233442201584" "False" "Low" "IsMasterProtein" "Q5TC63" "Growth hormone-regulated TBC protein 1 OS=Homo sapiens OX=9606 GN=GRTP1 PE=1 SV=4" "0.081" "False" "1.121" "2" "1" "1" "1" "336" "38.5" "8.78" "2.86" "1" "" "" "enzyme regulator activity" "Pf00566" "79774" "ENSG00000139835" "GRTP1" "B9A6K2; hsa:79774; Q2M232; Q5TC63; Q5TC64; Q66K26; Q6P659; Q8N528; Q9H695" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2991738215664900028" "False" "Low" "IsMasterProtein" "Q6NUN0" "Acyl-coenzyme A synthetase ACSM5, mitochondrial OS=Homo sapiens OX=9606 GN=ACSM5 PE=1 SV=2" "0.081" "False" "1.120" "2" "1" "1" "1" "579" "64.7" "8.40" "0.00" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "54988" "ENSG00000183549" "ACSM5" "hsa:54988; Q6NUN0; Q96AV1; Q96CX8; Q9NWV3" "" "Aspirin ADME; Conjugation of salicylate with glycine" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "614843859056000654" "False" "Low" "IsMasterProtein" "Q9UFE4" "Coiled-coil domain-containing protein 39 OS=Homo sapiens OX=9606 GN=CCDC39 PE=1 SV=3" "0.081" "False" "1.120" "1" "1" "1" "1" "941" "109.8" "6.44" "2.59" "1" "cell organization and biogenesis;transport;developmental processes;other biological processes" "non-structural extracellular;cytosol;cytoskeleton;other cell component" "" "" "339829" "ENSG00000284862" "CCDC39" "B4E2H1; hsa:339829; Q9UFE4" "Ciliopathies" "" "1" "0" "1.013" "0.979" "0.956" "0.881" "0.928" "1.005" "0.976" "0.899" "1.117" "177.0" "179.3" "173.2" "169.1" "155.9" "164.2" "177.8" "172.6" "159.0" "197.7" "" "" "" "" "" "" "" "" "" "" "159.1" "145.1" "156.7" "165.0" "128.6" "164.2" "133.1" "152.5" "142.3" "70.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7812634382890342947" "False" "Low" "IsMasterProtein" "Q7Z5P9" "Mucin-19 OS=Homo sapiens OX=9606 GN=MUC19 PE=1 SV=3" "0.081" "False" "1.119" "0" "1" "1" "1" "8384" "804.8" "5.01" "2.36" "1" "" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi" "" "Pf00094, Pf01826, Pf08742" "283463" "" "MUC19" "G3CIG0; hsa:283463; Q7Z5P9; Q8NA85" "" "Dectin-2 family; Termination of O-glycan biosynthesis; Defective GALNT3 causes HFTC; Defective C1GALT1C1 causes TNPS; Defective GALNT12 causes CRCS1" "6" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1077010323683599340" "False" "Low" "IsMasterProtein" "Q9NXU5" "ADP-ribosylation factor-like protein 15 OS=Homo sapiens OX=9606 GN=ARL15 PE=1 SV=1" "0.082" "False" "1.118" "4" "1" "1" "1" "204" "22.9" "5.63" "2.52" "1" "" "" "other molecular function" "Pf00025" "54622" "ENSG00000185305" "ARL15" "hsa:54622; Q6IAD0; Q9NXU5" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1716020948804202266" "False" "Low" "IsMasterProtein" "Q5H9F3" "BCL-6 corepressor-like protein 1 OS=Homo sapiens OX=9606 GN=BCORL1 PE=1 SV=2" "0.082" "False" "1.117" "0" "1" "1" "1" "1785" "190.4" "7.85" "1.73" "1" "cell organization and biogenesis;other biological processes" "plasma membrane;other membranes;nucleus" "other molecular function" "Pf12796, Pf16553" "63035" "ENSG00000085185" "BCORL1" "B5MDQ8; hsa:63035; Q5H9F2; Q5H9F3; Q5H9F4; Q6ZVE0; Q8TEN3; Q9Y528" "Mesodermal commitment pathway; Pathways affected in adenoid cystic carcinoma" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8857115664644385408" "False" "Low" "IsMasterProtein" "Q9H2B2" "Synaptotagmin-4 OS=Homo sapiens OX=9606 GN=SYT4 PE=1 SV=1" "0.083" "False" "1.117" "2" "1" "1" "1" "425" "47.9" "8.53" "2.57" "1" "cell-cell signaling;cell organization and biogenesis;transport;other biological processes" "non-structural extracellular;plasma membrane;other membranes;ER/Golgi;other cell component" "other molecular function" "Pf00168" "6860" "ENSG00000132872" "SYT4" "B4DEU3; hsa:6860; Q9H2B2; Q9P2K4" "" "" "0" "0" "0.927" "0.881" "0.864" "0.984" "0.919" "0.841" "0.893" "0.980" "1.108" "299.9" "277.8" "264.1" "259.1" "295.0" "275.7" "252.2" "267.6" "294.0" "332.2" "" "" "" "" "" "" "" "" "" "" "269.6" "224.8" "238.9" "252.9" "243.4" "275.7" "188.8" "236.4" "263.0" "118.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8386835206509726591" "False" "Low" "IsMasterProtein" "B2RXF5" "Zinc finger and BTB domain-containing protein 42 OS=Homo sapiens OX=9606 GN=ZBTB42 PE=1 SV=2" "0.082" "False" "1.117" "4" "1" "1" "1" "422" "46.5" "8.47" "2.16" "1" "other biological processes" "plasma membrane;other membranes;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096, Pf00651, Pf13894" "100128927" "ENSG00000179627" "ZBTB42" "B2RXF5; B7ZW21; hsa:100128927" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4105769586193157402" "False" "Low" "IsMasterProtein" "Q02410" "Amyloid-beta A4 precursor protein-binding family A member 1 OS=Homo sapiens OX=9606 GN=APBA1 PE=1 SV=3" "0.082" "False" "1.115" "2" "1" "1" "1" "837" "92.8" "4.93" "0.00" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;transport;developmental processes;other biological processes" "plasma membrane;other membranes;cytosol;ER/Golgi;nucleus;other cell component" "other molecular function" "Pf00595, Pf00640" "320" "ENSG00000107282" "APBA1" "hsa:320; O14914; O60570; Q02410; Q5VYR8" "" "Neurexins and neuroligins; Assembly and cell surface presentation of NMDA receptors; Dopamine Neurotransmitter Release Cycle" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3429518854929647245" "False" "Low" "IsMasterProtein" "Q9HD23" "Magnesium transporter MRS2 homolog, mitochondrial OS=Homo sapiens OX=9606 GN=MRS2 PE=1 SV=1" "0.083" "False" "1.111" "2" "1" "1" "1" "443" "50.3" "6.87" "3.07" "1" "other metabolic processes;transport" "other membranes;mitochondrion" "transporter activity" "" "57380" "ENSG00000124532" "MRS2" "A8K4U3; B3KNN2; B4DQL2; hsa:57380; Q5T3Y1; Q6NTG4; Q96KF8; Q9BVP1; Q9HD23" "" "Miscellaneous transport and binding events" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "7013098245942053338" "False" "Low" "IsMasterProtein" "Q8IWT3" "Cullin-9 OS=Homo sapiens OX=9606 GN=CUL9 PE=1 SV=2" "0.083" "False" "1.109" "0" "1" "1" "1" "2517" "281.0" "5.45" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "Pf00888, Pf01485, Pf03256, Pf11515" "23113" "ENSG00000112659" "CUL9" "hsa:23113; O75188; Q5TCY3; Q68CP2; Q68D92; Q8IWT3; Q8N3W9; Q9BU56" "" "Neddylation" "1" "0" "1.075" "0.988" "1.147" "1.075" "0.920" "1.083" "1.180" "0.979" "1.315" "45.5" "48.9" "45.0" "52.3" "49.0" "41.9" "49.3" "53.7" "44.6" "59.9" "" "" "" "" "" "" "" "" "" "" "41.0" "39.6" "40.7" "51.0" "40.4" "41.9" "36.9" "47.5" "39.9" "21.4" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8298200234612729181" "False" "Low" "IsMasterProtein" "P46527" "Cyclin-dependent kinase inhibitor 1B OS=Homo sapiens OX=9606 GN=CDKN1B PE=1 SV=1" "0.083" "False" "1.109" "6" "1" "1" "1" "198" "22.1" "7.02" "0.00" "1" "cell cycle OR cell proliferation;other metabolic processes;stress response;transport;developmental processes;signal transduction;other biological processes" "cytosol;nucleus;other cytoplasmic organelle;other cell component" "enzyme regulator activity;other molecular function" "Pf02234" "1027" "ENSG00000111276" "CDKN1B" "hsa:1027; P46527; Q16307; Q5U0H2; Q9BUS6" "miRNA regulation of DNA damage response; miRNAs involved in DNA damage response; Cell cycle; Integrated cancer pathway; Thyroid stimulating hormone (TSH) signaling pathway; IL-7 signaling pathway; Glioblastoma signaling pathways; Oncostatin M signaling pathway; Spinal cord injury; Retinoblastoma gene in cancer; Primary focal segmental glomerulosclerosis (FSGS); Aryl hydrocarbon receptor pathway; Apoptosis-related network due to altered Notch3 in ovarian cancer; Aryl hydrocarbon receptor pathway; Vitamin D receptor pathway; Nuclear receptors meta-pathway; Ovarian infertility; Imatinib and chronic myeloid leukemia; Physico-chemical features and toxicity-associated pathways; PI3K-AKT-mTOR signaling pathway and therapeutic opportunities in prostate cancer; Focal adhesion: PI3K-Akt-mTOR-signaling pathway; miR-222 in exercise-induced cardiac growth; Oxidative damage response; miRNA regulation of prostate cancer signaling pathways; PI3K-Akt signaling pathway; G1 to S cell cycle control; Measles virus infection; Small cell lung cancer; Gastrin signaling pathway; Galanin receptor pathway; Modulators of TCR signaling and T cell activation; DYRK1A involvement regarding cell proliferation in brain development; TROP2 regulatory signaling; ErbB signaling pathway; DNA damage response; DNA damage response (only ATM dependent)" "Constitutive Signaling by AKT1 E17K in Cancer; Estrogen-dependent nuclear events downstream of ESR-membrane signaling; TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest; SCF(Skp2)-mediated degradation of p27/p21; Senescence-Associated Secretory Phenotype (SASP); DNA Damage/Telomere Stress Induced Senescence; p53-Dependent G1 DNA Damage Response; Cyclin D associated events in G1; Defective binding of RB1 mutants to E2F1,(E2F2, E2F3); RHO GTPases activate CIT; FOXO-mediated transcription of cell cycle genes; AKT phosphorylates targets in the cytosol; FLT3 Signaling; PTK6 Regulates Cell Cycle" "52" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-6832072519945483932" "False" "Low" "IsMasterProtein" "Q6P0N0" "Mis18-binding protein 1 OS=Homo sapiens OX=9606 GN=MIS18BP1 PE=1 SV=1" "0.084" "False" "1.104" "1" "1" "1" "1" "1132" "129.0" "9.25" "1.94" "1" "cell cycle OR cell proliferation;other biological processes" "nucleus;other cell component" "nucleic acid binding activity" "Pf09133" "55320" "ENSG00000129534" "MIS18BP1" "D3DSA7; hsa:55320; Q6P0N0; Q86V14; Q96PY4; Q9NUR5; Q9Y4X9" "" "Deposition of new CENPA-containing nucleosomes at the centromere" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "309622094588707554" "False" "Low" "IsMasterProtein" "Q9UHK0" "FMR1-interacting protein NUFIP1 OS=Homo sapiens OX=9606 GN=NUFIP1 PE=1 SV=2" "0.084" "False" "1.103" "2" "1" "1" "1" "495" "56.3" "9.13" "2.12" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf10453" "26747" "ENSG00000083635" "NUFIP1" "hsa:26747; Q8WVM5; Q96SG1; Q9UHK0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1663348856479842689" "False" "Low" "IsMasterProtein" "Q96BM1" "Ankyrin repeat domain-containing protein 9 OS=Homo sapiens OX=9606 GN=ANKRD9 PE=1 SV=1" "0.084" "False" "1.103" "6" "1" "1" "1" "317" "34.3" "9.47" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "cytosol;other cell component" "other molecular function" "" "122416" "ENSG00000156381" "ANKRD9" "A8K753; Q96BM1" "" "Neddylation" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "1909433531537133344" "False" "Low" "IsMasterProtein" "O14967" "Calmegin OS=Homo sapiens OX=9606 GN=CLGN PE=1 SV=1" "0.084" "False" "1.102" "2" "1" "1" "1" "610" "70.0" "4.69" "0.00" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00262" "1047" "ENSG00000153132" "CLGN" "B3KS90; B4DXV8; D3DNY8; hsa:1047; O14967" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-216543890695759546" "False" "Low" "IsMasterProtein" "Q53EL9" "Seizure protein 6 homolog OS=Homo sapiens OX=9606 GN=SEZ6 PE=1 SV=2" "0.084" "False" "1.102" "1" "1" "1" "1" "994" "107.4" "5.34" "0.00" "1" "cell-cell signaling;cell organization and biogenesis;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cell component" "" "Pf00084, Pf00431" "124925" "ENSG00000063015" "SEZ6" "B6ZDN1; hsa:124925; Q53EL9; Q8N701; Q8NB57; Q8ND50; Q8TD25; Q96NI5; Q96NQ3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4648146682838511012" "False" "Low" "IsMasterProtein" "Q9NUT2" "Mitochondrial potassium channel ATP-binding subunit OS=Homo sapiens OX=9606 GN=ABCB8 PE=1 SV=3" "0.084" "False" "1.101" "2" "1" "1" "1" "735" "79.9" "8.98" "0.00" "1" "cell organization and biogenesis;transport" "plasma membrane;other membranes;mitochondrion;nucleus" "transporter activity;other molecular function" "Pf00005, Pf00664" "11194" "ENSG00000197150" "ABCB8" "A5D8W3; B2RBL8; B3KND2; B4DG02; G3XAP3; hsa:11194; O95787; Q53GM0; Q9NUT2" "" "Mitochondrial ABC transporters" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2887572586952269824" "False" "Low" "IsMasterProtein" "Q9HCE1" "Helicase MOV-10 OS=Homo sapiens OX=9606 GN=MOV10 PE=1 SV=2" "0.084" "False" "1.100" "1" "1" "1" "1" "1003" "113.6" "8.82" "2.36" "1" "stress response;other biological processes" "cytosol;nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf13086, Pf13087, Pf21632, Pf21633, Pf21634, Pf21635" "4343" "ENSG00000155363" "MOV10" "hsa:4343; Q5JR03; Q8TEF0; Q9BSY3; Q9BUJ9; Q9HCE1" "VEGFA-VEGFR2 signaling" "TP53 Regulates Metabolic Genes; MAPK6/MAPK4 signaling; Oxidative Stress Induced Senescence; Estrogen-dependent gene expression; Pre-NOTCH Transcription and Translation; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function; Oncogene Induced Senescence; Transcriptional Regulation by VENTX; Ca2+ pathway; Regulation of MECP2 expression and activity; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux; Nuclear events stimulated by ALK signaling in cancer; Regulation of RUNX1 Expression and Activity; Regulation of CDH11 mRNA translation by microRNAs; Regulation of NPAS4 mRNA translation; Competing endogenous RNAs (ceRNAs) regulate PTEN translation" "19" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6680775627371570044" "False" "Low" "IsMasterProtein" "Q9Y6V0" "Protein piccolo OS=Homo sapiens OX=9606 GN=PCLO PE=1 SV=5" "0.085" "False" "1.099" "0" "1" "1" "1" "5142" "560.4" "6.47" "1.79" "1" "cell-cell signaling;cell organization and biogenesis;transport;developmental processes;signal transduction;other biological processes" "cytoskeleton;other cell component" "other molecular function" "Pf00168, Pf00595, Pf05715" "27445" "ENSG00000186472" "PCLO" "A4D1A7; A6NNX9; O43373; O60305; Q08E72; Q9BVC8; Q9UIV2; Q9Y6U9; Q9Y6V0" "Cell lineage map for neuronal differentiation" "Sensory processing of sound by inner hair cells of the cochlea" "2" "0" "1.019" "1.155" "0.857" "1.045" "1.100" "1.008" "1.075" "0.993" "0.776" "52.7" "53.7" "60.9" "45.2" "55.1" "58.0" "53.1" "56.7" "52.3" "40.9" "" "" "" "" "" "" "" "" "" "" "47.4" "43.5" "55.0" "44.1" "45.5" "58.0" "39.8" "50.1" "46.8" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2689761144797840992" "False" "Low" "IsMasterProtein" "Q5T8A7" "Protein phosphatase 1 regulatory subunit 26 OS=Homo sapiens OX=9606 GN=PPP1R26 PE=1 SV=1" "0.085" "False" "1.098" "1" "1" "1" "1" "1209" "127.3" "8.59" "0.00" "1" "" "nucleus" "enzyme regulator activity" "Pf15740" "9858" "ENSG00000196422" "PPP1R26" "hsa:9858; Q5T8A7; Q86WU0; Q8WVV0; Q9Y4D3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1322604588450231993" "False" "Low" "IsMasterProtein" "P31629" "Transcription factor HIVEP2 OS=Homo sapiens OX=9606 GN=HIVEP2 PE=1 SV=2" "0.085" "False" "1.097" "1" "1" "1" "1" "2446" "268.9" "6.96" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096" "3097" "ENSG00000010818" "HIVEP2" "hsa:3097; P31629; Q02646; Q5THT5; Q9NS05" "Rett syndrome" "" "1" "0" "1.106" "1.037" "1.649" "1.125" "1.167" "0.877" "0.984" "1.327" "1.085" "45.1" "49.9" "46.8" "74.4" "50.8" "52.7" "39.6" "44.4" "59.9" "49.0" "" "" "" "" "" "" "" "" "" "" "40.6" "40.4" "42.4" "72.7" "41.9" "52.7" "29.6" "39.2" "53.6" "17.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-782504284023917149" "False" "Low" "IsMasterProtein" "Q8NFP0" "Peroxisomal testis-specific protein 1 OS=Homo sapiens OX=9606 GN=PXT1 PE=1 SV=2" "0.085" "False" "1.096" "7" "1" "1" "1" "134" "16.0" "9.09" "0.00" "1" "other biological processes" "nucleus;other cytoplasmic organelle" "" "Pf15214" "222659" "ENSG00000179165" "PXT1" "hsa:222659; J3KR74; Q8NFP0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8566659987673316971" "False" "Low" "IsMasterProtein" "Q969I3" "Glycine N-acyltransferase-like protein 1 OS=Homo sapiens OX=9606 GN=GLYATL1 PE=1 SV=1" "0.085" "False" "1.094" "2" "1" "1" "1" "302" "35.1" "6.87" "0.00" "1" "other metabolic processes" "mitochondrion" "other molecular function" "Pf06021, Pf08444" "92292" "ENSG00000166840" "GLYATL1" "A6NDT0; hsa:92292; Q7Z510; Q8NAW8; Q969I3" "Amino acid conjugation of benzoic acid; Metapathway biotransformation Phase I and II" "Aspirin ADME; Conjugation of salicylate with glycine; Conjugation of benzoate with glycine" "5" "0" "0.980" "1.340" "0.993" "1.065" "1.051" "0.900" "0.784" "1.070" "1.084" "85.3" "83.7" "114.3" "84.7" "90.8" "89.7" "76.8" "66.9" "91.3" "92.5" "" "" "" "" "" "" "" "" "" "" "76.7" "67.7" "103.4" "82.7" "75.0" "89.7" "57.5" "59.1" "81.7" "33.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8411894831205011543" "False" "Low" "IsMasterProtein" "Q7L8J4" "SH3 domain-binding protein 5-like OS=Homo sapiens OX=9606 GN=SH3BP5L PE=1 SV=1" "0.085" "False" "1.094" "2" "1" "1" "1" "393" "43.5" "5.77" "2.57" "1" "signal transduction" "other cell component" "enzyme regulator activity" "Pf05276" "80851" "ENSG00000175137" "SH3BP5L" "B4DQ94; hsa:80851; Q7L8J4; Q96FI5; Q9BQH8; Q9C0E3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4503550903694701286" "False" "Low" "IsMasterProtein" "O60504" "Vinexin OS=Homo sapiens OX=9606 GN=SORBS3 PE=1 SV=2" "0.085" "False" "1.091" "1" "1" "1" "1" "671" "75.3" "9.45" "0.00" "1" "cell adhesion;cell organization and biogenesis;signal transduction;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity" "Pf00018, Pf02208, Pf14604" "10174" "ENSG00000120896" "SORBS3" "hsa:10174; O60504; Q5BJE4; Q6NX54; Q96FY4; Q9UQE4" "" "Smooth Muscle Contraction" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1539754074245543228" "False" "Low" "IsMasterProtein" "O94986" "Centrosomal protein of 152 kDa OS=Homo sapiens OX=9606 GN=CEP152 PE=1 SV=4" "0.086" "False" "1.090" "0" "1" "1" "1" "1710" "195.5" "5.60" "2.48" "1" "cell cycle OR cell proliferation;cell organization and biogenesis" "cytosol;cytoskeleton;nucleus;other cell component" "other molecular function" "" "22995" "ENSG00000103995" "CEP152" "E7ER66; hsa:22995; O94986; Q17RV1; Q6NTA0" "" "Recruitment of NuMA to mitotic centrosomes; Regulation of PLK1 Activity at G2/M Transition; Loss of Nlp from mitotic centrosomes; Recruitment of mitotic centrosome proteins and complexes; Anchoring of the basal body to the plasma membrane; AURKA Activation by TPX2" "7" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5583372795952313284" "False" "Low" "IsMasterProtein" "Q12889" "Oviduct-specific glycoprotein OS=Homo sapiens OX=9606 GN=OVGP1 PE=1 SV=1" "0.086" "False" "1.089" "2" "1" "1" "1" "678" "75.4" "8.78" "1.60" "1" "other metabolic processes;other biological processes" "non-structural extracellular;extracellular matrix;cytosol;cytoskeleton;ER/Golgi;other cell component" "other molecular function" "Pf00704" "5016" "ENSG00000085465" "OVGP1" "A0AV19; B9EGE1; Q12889; Q15841" "" "Interaction With Cumulus Cells And The Zona Pellucida" "1" "0" "0.826" "0.990" "0.702" "0.871" "0.981" "1.061" "0.842" "1.073" "0.805" "40.0" "33.0" "39.6" "28.1" "34.8" "39.2" "42.4" "33.6" "42.9" "32.2" "" "" "" "" "" "" "" "" "" "" "35.9" "26.7" "35.8" "27.4" "28.7" "39.2" "31.7" "29.7" "38.4" "11.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "464590706155418975" "False" "Low" "IsMasterProtein" "Q9HB29" "Interleukin-1 receptor-like 2 OS=Homo sapiens OX=9606 GN=IL1RL2 PE=1 SV=2" "0.086" "False" "1.087" "2" "1" "1" "1" "575" "65.4" "7.46" "0.00" "1" "stress response;signal transduction;other biological processes" "plasma membrane;other membranes" "other molecular function" "Pf01582, Pf13895" "8808" "ENSG00000115598" "IL1RL2" "A4FU63; hsa:8808; Q13525; Q45H74; Q53TU8; Q587I8; Q9HB29" "2q13 copy number variation syndrome" "Interleukin-38 signaling; Interleukin-36 pathway" "3" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5560504805324991251" "False" "Low" "IsMasterProtein" "Q9UQ53" "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B OS=Homo sapiens OX=9606 GN=MGAT4B PE=1 SV=1" "0.086" "False" "1.085" "3" "1" "1" "1" "548" "63.2" "7.87" "0.00" "1" "protein metabolism;other metabolic processes;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf04666" "11282" "ENSG00000161013; ENSG00000284501" "MGAT4B" "A8MPR0; hsa:11282; Q86TF1; Q96GH4; Q9NSK6; Q9UQ53" "" "N-Glycan antennae elongation; Maturation of spike protein" "2" "0" "0.967" "0.926" "1.187" "1.109" "0.822" "1.404" "1.097" "0.956" "1.244" "32.9" "31.8" "30.5" "39.1" "36.5" "27.1" "46.2" "36.1" "31.5" "41.0" "" "" "" "" "" "" "" "" "" "" "29.6" "25.8" "27.6" "38.2" "30.2" "27.1" "34.6" "31.9" "28.2" "14.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8727669707947595879" "False" "Low" "IsMasterProtein" "Q15058" "Kinesin-like protein KIF14 OS=Homo sapiens OX=9606 GN=KIF14 PE=1 SV=1" "0.086" "False" "1.085" "1" "1" "1" "1" "1648" "186.4" "7.91" "0.00" "1" "cell adhesion;cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;other metabolic processes;developmental processes;other biological processes" "cytosol;cytoskeleton;nucleus;other cell component" "cytoskeletal activity;other molecular function" "Pf00225, Pf00498, Pf16183" "9928" "ENSG00000118193" "KIF14" "hsa:9928; Q14CI8; Q15058; Q4G0A5; Q5T1W3" "" "RND2 GTPase cycle; RND1 GTPase cycle; RHO GTPases activate CIT" "3" "0" "0.963" "0.968" "0.828" "1.135" "0.849" "1.044" "0.961" "1.035" "0.991" "68.7" "66.2" "66.6" "56.9" "78.0" "58.3" "71.8" "66.1" "71.1" "68.1" "" "" "" "" "" "" "" "" "" "" "61.8" "53.5" "60.2" "55.5" "64.4" "58.3" "53.7" "58.3" "63.6" "24.3" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1634644126627239875" "False" "Low" "IsMasterProtein" "Q96MI9" "Cytosolic carboxypeptidase 4 OS=Homo sapiens OX=9606 GN=AGBL1 PE=1 SV=3" "0.087" "False" "1.083" "1" "1" "1" "1" "1112" "125.3" "7.14" "2.51" "1" "protein metabolism;other metabolic processes" "cytosol" "cytoskeletal activity;other molecular function" "Pf00246, Pf18027" "123624" "ENSG00000273540" "AGBL1" "A0A1C7CYX3; A1A4X5; A6NJH6; C9JHL5; hsa:123624; Q96MI9" "" "Carboxyterminal post-translational modifications of tubulin" "1" "0" "1.207" "1.179" "1.100" "1.137" "0.944" "1.365" "1.113" "1.041" "1.510" "175.5" "211.8" "207.0" "193.0" "199.5" "165.7" "239.5" "195.3" "182.7" "265.1" "" "" "" "" "" "" "" "" "" "" "157.8" "171.4" "187.2" "188.4" "164.6" "165.7" "179.4" "172.5" "163.4" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1427297230371715365" "False" "Low" "IsMasterProtein" "Q6UB99" "Ankyrin repeat domain-containing protein 11 OS=Homo sapiens OX=9606 GN=ANKRD11 PE=1 SV=3" "0.087" "False" "1.082" "1" "1" "1" "1" "2663" "297.7" "7.11" "0.00" "1" "developmental processes;other biological processes" "cytosol;nucleus" "" "Pf12796" "29123" "ENSG00000167522" "ANKRD11" "hsa:29123; Q6NTG1; Q6QMF8; Q6UB99" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1043933861816378704" "False" "Low" "IsMasterProtein" "O60303" "Katanin-interacting protein OS=Homo sapiens OX=9606 GN=KATNIP PE=1 SV=4" "0.087" "False" "1.081" "0" "1" "1" "1" "1618" "180.8" "5.87" "2.61" "1" "transport" "cytoskeleton;other cell component" "" "Pf14652" "23247" "ENSG00000047578" "KATNIP" "A7E2C2; hsa:23247; O60303" "Ciliopathies" "" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "816627375717450004" "False" "Low" "IsMasterProtein" "Q86WR7" "Proline and serine-rich protein 2 OS=Homo sapiens OX=9606 GN=PROSER2 PE=1 SV=2" "0.087" "False" "1.081" "2" "1" "1" "1" "435" "45.8" "7.20" "0.00" "1" "" "" "" "Pf15385" "254427" "ENSG00000148426" "PROSER2" "D3DRR8; hsa:254427; Q5W0J9; Q5W0K0; Q5W0K1; Q5W0K2; Q6PJC8; Q86WR7; Q8N317" "" "" "0" "0" "1.058" "1.166" "0.755" "0.953" "0.836" "0.491" "0.848" "0.867" "0.905" "92.5" "97.9" "107.9" "69.8" "88.2" "77.4" "45.4" "78.5" "80.2" "83.7" "" "" "" "" "" "" "" "" "" "" "83.2" "79.2" "97.6" "68.2" "72.8" "77.4" "34.0" "69.4" "71.8" "29.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1310658441367926589" "False" "Low" "IsMasterProtein" "Q14586" "Zinc finger protein 267 OS=Homo sapiens OX=9606 GN=ZNF267 PE=1 SV=3" "0.087" "False" "1.081" "2" "1" "1" "1" "743" "87.3" "8.91" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "10308" "ENSG00000185947" "ZNF267" "A0JNZ9; hsa:10308; Q14586; Q8NE41; Q9NRJ0" "" "Generic Transcription Pathway" "1" "0" "1.189" "1.000" "1.245" "1.428" "1.479" "1.451" "1.227" "1.215" "0.010" "10.8" "12.8" "10.8" "13.4" "15.4" "15.9" "15.6" "13.2" "13.1" "0.0" "" "" "" "" "" "" "" "" "" "" "9.7" "10.3" "9.7" "13.1" "12.7" "15.9" "11.7" "11.7" "11.7" "0.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "2890344552958539961" "False" "Low" "IsMasterProtein" "O75569" "Interferon-inducible double-stranded RNA-dependent protein kinase activator A OS=Homo sapiens OX=9606 GN=PRKRA PE=1 SV=1" "0.087" "False" "1.078" "3" "1" "1" "1" "313" "34.4" "8.41" "2.43" "1" "cell organization and biogenesis;RNA metabolism OR transcription;other metabolic processes;stress response;developmental processes;other biological processes" "cytosol;nucleus;other cell component" "enzyme regulator activity;nucleic acid binding activity;other molecular function" "Pf00035" "8575" "ENSG00000180228" "PRKRA" "A8K3I6; hsa:8575; O75569; Q53G24; Q6X7T5; Q8NDK4" "VEGFA-VEGFR2 signaling; Ebola virus infection in host" "PKR-mediated signaling; MicroRNA (miRNA) biogenesis; Small interfering RNA (siRNA) biogenesis" "5" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8476408954853743053" "False" "Low" "IsMasterProtein" "Cont_Q9NSB4" "Keratin, type II cuticular Hb2 OS=Homo sapiens OX=9606 GN=KRT82 PE=1 SV=3" "0.088" "True" "1.078" "3" "1" "1" "1" "513" "56.6" "6.74" "0.00" "1" "cell organization and biogenesis;other biological processes" "cytosol;cytoskeleton" "bone, tooth or skin structural activity" "Pf00038, Pf16208" "3888" "ENSG00000161850" "KRT82" "hsa:3888; Q9NSB4" "" "Formation of the cornified envelope" "2" "0" "1.210" "0.672" "0.751" "0.941" "1.012" "1.052" "1.013" "0.930" "0.572" "20.6" "25.0" "13.9" "15.5" "19.4" "20.9" "21.7" "20.9" "19.2" "11.8" "" "" "" "" "" "" "" "" "" "" "18.6" "20.2" "12.5" "15.1" "16.0" "20.9" "16.3" "18.5" "17.2" "4.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5297574850053295946" "False" "Low" "IsMasterProtein" "Q6NX49" "Zinc finger protein 544 OS=Homo sapiens OX=9606 GN=ZNF544 PE=1 SV=1" "0.088" "False" "1.078" "3" "1" "1" "1" "715" "81.7" "7.84" "0.00" "1" "other biological processes" "nucleus" "nucleic acid binding activity;other molecular function" "Pf00096, Pf01352" "27300" "ENSG00000198131" "ZNF544" "A8K6J1; hsa:27300; Q6NX49; Q9UEX4" "" "Generic Transcription Pathway" "1" "0" "0.942" "0.850" "0.947" "1.014" "0.643" "1.173" "0.925" "0.989" "0.819" "34.9" "32.9" "29.7" "33.1" "35.4" "22.5" "41.0" "32.3" "34.5" "28.6" "" "" "" "" "" "" "" "" "" "" "31.4" "26.6" "26.9" "32.3" "29.2" "22.5" "30.7" "28.5" "30.9" "10.2" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1683732576426602574" "False" "Low" "IsMasterProtein" "Q2NL98" "Vimentin-type intermediate filament-associated coiled-coil protein OS=Homo sapiens OX=9606 GN=VMAC PE=1 SV=1" "0.088" "False" "1.077" "4" "1" "1" "1" "169" "18.3" "5.73" "2.53" "1" "" "cytoskeleton;other cell component" "" "" "400673" "ENSG00000187650; ENSG00000292061" "VMAC" "B3KW55; hsa:400673; Q2NL98" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "6869807393717083475" "False" "Low" "IsMasterProtein" "Q9Y2P4" "Long-chain fatty acid transport protein 6 OS=Homo sapiens OX=9606 GN=SLC27A6 PE=1 SV=1" "0.088" "False" "1.076" "1" "1" "1" "1" "619" "70.1" "8.51" "0.00" "1" "other metabolic processes;transport" "plasma membrane;other membranes" "transporter activity;other molecular function" "Pf00501, Pf13193" "28965" "ENSG00000113396" "SLC27A6" "hsa:28965; Q6IAM5; Q7Z6E6; Q86YF6; Q9Y2P4" "PPAR signaling pathway" "Transport of fatty acids" "2" "0" "1.066" "1.130" "0.961" "1.232" "0.958" "1.036" "1.057" "1.250" "0.727" "79.2" "84.4" "89.5" "76.1" "97.6" "75.8" "82.1" "83.7" "99.0" "57.6" "" "" "" "" "" "" "" "" "" "" "71.2" "68.3" "80.9" "74.3" "80.5" "75.8" "61.4" "73.9" "88.6" "20.5" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-3258853358595528558" "False" "Low" "IsMasterProtein" "Q9H8T0" "AKT-interacting protein OS=Homo sapiens OX=9606 GN=AKTIP PE=1 SV=1" "0.088" "False" "1.075" "2" "1" "1" "1" "292" "33.1" "9.31" "1.77" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;cytosol;nucleus;other cell component" "other molecular function" "Pf00179" "64400" "ENSG00000166971" "AKTIP" "hsa:64400; Q503B1; Q53H38; Q9H8T0" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3441989282213060776" "False" "Low" "IsMasterProtein" "Q16552" "Interleukin-17A OS=Homo sapiens OX=9606 GN=IL17A PE=1 SV=1" "0.088" "False" "1.074" "5" "1" "1" "1" "155" "17.5" "8.50" "2.21" "1" "cell-cell signaling;cell cycle OR cell proliferation;other metabolic processes;stress response;signal transduction;other biological processes" "non-structural extracellular;plasma membrane;other membranes" "signal transduction activity or receptor binding;other molecular function" "Pf06083" "3605" "ENSG00000112115" "IL17A" "hsa:3605; Q16552; Q5T2P0" "IL-17 signaling pathway; Allograft rejection; Development and heterogeneity of the ILC family; Prostaglandin signaling; Overview of proinflammatory and profibrotic mediators; Th17 cell differentiation pathway; Comprehensive IL-17A signaling; COVID-19 and endothelial cell senescence; Neurogenesis regulation in the olfactory epithelium; Immune infiltration in pancreatic cancer; IL-26 signaling pathways; T-cell receptor signaling pathway" "SARS-CoV-2 activates/modulates innate and adaptive immune responses; Interleukin-4 and Interleukin-13 signaling; Interleukin-17 signaling" "15" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "4004178596345168226" "False" "Low" "IsMasterProtein" "Q8IWR1" "Tripartite motif-containing protein 59 OS=Homo sapiens OX=9606 GN=TRIM59 PE=1 SV=1" "0.088" "False" "1.074" "3" "1" "1" "1" "403" "47.1" "6.81" "0.00" "1" "protein metabolism;other metabolic processes;stress response;other biological processes" "other membranes;ER/Golgi" "other molecular function" "Pf00643, Pf13445" "286827" "ENSG00000213186" "TRIM59" "A8K5G9; D3DNL9; hsa:286827; Q8IWR1" "" "" "0" "0" "1.301" "1.315" "1.340" "1.328" "0.949" "1.129" "1.064" "0.963" "0.699" "28.5" "37.1" "37.5" "38.2" "37.8" "27.0" "32.2" "30.3" "27.4" "19.9" "" "" "" "" "" "" "" "" "" "" "25.6" "30.0" "33.9" "37.2" "31.2" "27.0" "24.1" "26.8" "24.5" "7.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7947214601009221586" "False" "Low" "IsMasterProtein" "Q11203" "CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase OS=Homo sapiens OX=9606 GN=ST3GAL3 PE=1 SV=1" "0.088" "False" "1.073" "2" "1" "1" "1" "375" "42.1" "8.98" "1.76" "1" "protein metabolism;other metabolic processes;other biological processes" "non-structural extracellular;other membranes;ER/Golgi" "other molecular function" "Pf00777" "6487" "ENSG00000126091" "ST3GAL3" "A9Z1W2; D3DPX8; hsa:6487; Q11203; Q5T4W9; Q5T4X0; Q5T4X7; Q5T4X8; Q5T4X9; Q5T4Y0; Q5T4Y2; Q5T4Y3; Q5T4Y4; Q86UR6; Q86UR7; Q86UR8; Q86UR9; Q86US0; Q86US1; Q86US2; Q8IX41; Q8IX42; Q8IX43; Q8IX44; Q8IX45; Q8IX46; Q8IX47; Q8IX48; Q8IX49; Q8IX50; Q8IX51; Q8IX52; Q8IX53; Q8IX54; Q8IX55; Q8IX56; Q8IX57; Q8IX58" "" "Pre-NOTCH Processing in Golgi; Sialic acid metabolism; Glycosphingolipid biosynthesis; Keratan sulfate biosynthesis; Lewis blood group biosynthesis; Defective ST3GAL3 causes MCT12 and EIEE15; Maturation of spike protein; Maturation of protein 3a; Maturation of protein 3a; Termination of O-glycan biosynthesis" "10" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8090772672849701149" "False" "Low" "IsMasterProtein" "Q53FZ2" "Acyl-coenzyme A synthetase ACSM3, mitochondrial OS=Homo sapiens OX=9606 GN=ACSM3 PE=1 SV=2" "0.088" "False" "1.073" "1" "1" "1" "1" "586" "66.1" "9.04" "2.48" "1" "other metabolic processes;other biological processes" "mitochondrion" "other molecular function" "Pf00501, Pf13193" "6296" "ENSG00000005187" "ACSM3" "hsa:6296; O60363; Q13732; Q15425; Q53FZ2; Q7KYM6; Q9BUA2" "" "Beta oxidation of butanoyl-CoA to acetyl-CoA" "1" "0" "1.040" "1.012" "0.958" "1.070" "0.810" "1.053" "0.735" "0.859" "1.512" "94.7" "98.4" "95.8" "90.7" "101.3" "76.6" "99.7" "69.6" "81.3" "143.1" "" "" "" "" "" "" "" "" "" "" "85.1" "79.6" "86.7" "88.6" "83.6" "76.6" "74.7" "61.4" "72.8" "51.1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-7605118544862910658" "False" "Low" "IsMasterProtein" "Q9H0U3" "Magnesium transporter protein 1 OS=Homo sapiens OX=9606 GN=MAGT1 PE=1 SV=1" "0.088" "False" "1.073" "4" "1" "1" "1" "335" "38.0" "9.63" "0.00" "1" "protein metabolism;other metabolic processes;transport;other biological processes" "plasma membrane;other membranes;ER/Golgi;other cytoplasmic organelle" "transporter activity" "Pf04756" "84061" "ENSG00000102158" "MAGT1" "B2RAR4; D3DTE3; hsa:84061; Q53G00; Q6P577; Q8NBN6; Q9H0U3" "" "Neutrophil degranulation; Miscellaneous transport and binding events; Asparagine N-linked glycosylation; Maturation of spike protein" "4" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-2455795239582416474" "False" "Low" "IsMasterProtein" "Q8N6L0" "Protein KASH5 OS=Homo sapiens OX=9606 GN=KASH5 PE=1 SV=2" "0.088" "False" "1.071" "2" "1" "1" "1" "562" "62.7" "4.68" "2.14" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;DNA metabolism;stress response;other biological processes" "other membranes;cytoskeleton;nucleus;other cell component" "other molecular function" "Pf14658, Pf14662" "147872" "ENSG00000161609" "KASH5" "hsa:147872; Q8N6L0; Q96MC3" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "8884823842415202204" "False" "Low" "IsMasterProtein" "Q9BZF9" "Uveal autoantigen with coiled-coil domains and ankyrin repeats OS=Homo sapiens OX=9606 GN=UACA PE=1 SV=2" "0.088" "False" "1.071" "1" "1" "1" "1" "1416" "162.4" "7.03" "4.17" "1" "other biological processes" "non-structural extracellular;cytosol;cytoskeleton;nucleus" "cytoskeletal activity" "Pf12796" "55075" "ENSG00000137831" "UACA" "G3XAG2; hsa:55075; Q14DD3; Q8N3B8; Q96NH6; Q9BZF9; Q9HCL1; Q9NWC6" "" "Regulation of the apoptosome activity; RHOH GTPase cycle" "2" "0" "0.831" "1.048" "0.728" "0.798" "0.770" "0.709" "0.808" "0.748" "0.740" "358.5" "298.1" "375.7" "261.0" "286.0" "276.1" "254.3" "289.7" "268.2" "265.1" "" "" "" "" "" "" "" "" "" "" "322.3" "241.2" "339.8" "254.8" "236.1" "276.1" "190.4" "255.9" "240.0" "94.6" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-8382345813969270607" "False" "Low" "IsMasterProtein" "Q969H0" "F-box/WD repeat-containing protein 7 OS=Homo sapiens OX=9606 GN=FBXW7 PE=1 SV=1" "0.088" "False" "1.067" "2" "1" "1" "1" "707" "79.6" "5.80" "0.00" "1" "cell cycle OR cell proliferation;cell organization and biogenesis;protein metabolism;DNA metabolism;other metabolic processes;stress response;developmental processes;signal transduction;other biological processes" "cytosol;mitochondrion;ER/Golgi;nucleus;other cell component" "enzyme regulator activity;other molecular function" "Pf00400, Pf12937" "55294" "ENSG00000109670" "FBXW7" "B7ZLP9; hsa:55294; Q68DR0; Q969H0; Q96A16; Q96LE0; Q96RI2; Q9NUX6" "Parkin-ubiquitin proteasomal system pathway; Pathways affected in adenoid cystic carcinoma; IL-18 signaling pathway; 3q29 copy number variation syndrome; 5q35 copy number variation; Notch signaling pathway" "Association of TriC/CCT with target proteins during biosynthesis; Antigen processing: Ubiquitination & Proteasome degradation; Neddylation" "9" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "Not Found" "1" "" "2998075860950209884" "False" "Low" "IsMasterProtein" "Q9NXL9" "DNA helicase MCM9 OS=Homo sapiens OX=9606 GN=MCM9 PE=1 SV=4" "0.089" "False" "1.066" "1" "1" "1" "1" "1143" "127.2" "7.74" "2.08" "1" "cell organization and biogenesis;DNA metabolism;other metabolic processes;stress response;other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00493, Pf17207, Pf17855" "254394" "ENSG00000111877" "MCM9" "B4DR30; B9DI77; hsa:254394; Q2KHJ0; Q8N5S5; Q9HCV5; Q9NXL9" "Ciliary landscape; Primary ovarian insufficiency" "" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-5658162067205247997" "False" "Low" "IsMasterProtein" "Q969E2" "Secretory carrier-associated membrane protein 4 OS=Homo sapiens OX=9606 GN=SCAMP4 PE=1 SV=1" "0.088" "False" "1.066" "3" "1" "1" "1" "229" "25.7" "8.82" "0.00" "1" "transport" "other membranes;ER/Golgi;other cytoplasmic organelle" "" "Pf04144" "113178" "ENSG00000227500" "SCAMP4" "hsa:113178; Q8N2N1; Q8NAV0; Q969E2" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "698066811978605479" "False" "Low" "IsMasterProtein" "Q9C0B2" "Cilia- and flagella-associated protein 74 OS=Homo sapiens OX=9606 GN=CFAP74 PE=1 SV=3" "0.090" "False" "1.061" "1" "1" "1" "1" "1584" "178.5" "6.42" "1.93" "1" "cell organization and biogenesis" "cytoskeleton;nucleus;other cell component" "" "" "85452" "ENSG00000142609" "CFAP74" "A4VCI2; H7C4E1; hsa:85452; Q5T2D9; Q5T2E0; Q69YW0; Q6ZSJ4; Q9C0B2" "1p36 copy number variation syndrome" "" "1" "0" "0.887" "1.408" "0.983" "1.110" "1.207" "1.037" "1.007" "1.424" "1.238" "190.0" "168.5" "267.6" "186.8" "210.9" "229.5" "197.1" "191.4" "270.7" "235.2" "" "" "" "" "" "" "" "" "" "" "170.9" "136.3" "242.0" "182.3" "174.0" "229.5" "147.6" "169.0" "242.2" "84.0" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "3898709646125856874" "False" "Low" "IsMasterProtein" "Q02086" "Transcription factor Sp2 OS=Homo sapiens OX=9606 GN=SP2 PE=1 SV=3" "0.090" "False" "1.061" "1" "1" "1" "1" "613" "64.9" "9.92" "0.00" "1" "other biological processes" "nucleus;other cell component" "nucleic acid binding activity;other molecular function" "Pf00096" "6668" "ENSG00000167182" "SP2" "A6NK74; hsa:6668; Q02086" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-1566971242327954635" "False" "Low" "IsMasterProtein" "Q13308" "Inactive tyrosine-protein kinase 7 OS=Homo sapiens OX=9606 GN=PTK7 PE=1 SV=2" "0.090" "False" "1.060" "1" "1" "1" "1" "1070" "118.3" "7.09" "2.24" "1" "cell adhesion;cell-cell signaling;cell organization and biogenesis;stress response;developmental processes;signal transduction;other biological processes" "plasma membrane;other membranes;other cell component" "kinase activity;other molecular function" "Pf07679, Pf07714, Pf13927" "5754" "ENSG00000112655" "PTK7" "A8K974; B7Z477; E9PFZ5; hsa:5754; Q13308; Q13417; Q5T650; Q6IQ54; Q8NFA5; Q8NFA6; Q8NFA7; Q8NFA8" "" "" "0" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "5175550772712101410" "False" "Low" "IsMasterProtein" "Q9NU02" "Ankyrin repeat and EF-hand domain-containing protein 1 OS=Homo sapiens OX=9606 GN=ANKEF1 PE=1 SV=2" "0.091" "False" "1.059" "1" "1" "1" "1" "776" "86.6" "8.28" "2.57" "1" "" "" "other molecular function" "Pf12796" "63926" "ENSG00000132623" "ANKEF1" "B3KUQ0; hsa:63926; Q9H6Y9; Q9NU02" "" "" "0" "0" "0.901" "0.985" "0.906" "0.866" "0.874" "1.066" "0.955" "0.943" "0.641" "121.9" "109.9" "120.0" "110.4" "105.6" "106.5" "129.9" "116.5" "114.9" "78.1" "" "" "" "" "" "" "" "" "" "" "109.6" "88.9" "108.6" "107.8" "87.1" "106.5" "97.3" "102.9" "102.8" "27.9" "1" "1" "1" "1" "1" "1" "1" "1" "1" "1" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "-9059852176619998838" "False" "Low" "IsMasterProtein" "P31944" "Caspase-14 OS=Homo sapiens OX=9606 GN=CASP14 PE=1 SV=2" "0.091" "False" "1.059" "4" "1" "1" "1" "242" "27.7" "5.58" "2.73" "1" "protein metabolism;other biological processes" "plasma membrane;cytosol;cytoskeleton;mitochondrion;nucleus;other cell component" "other molecular function" "Pf00656" "23581" "ENSG00000105141" "CASP14" "O95823; P31944; Q3SYC9" "Vitamin D receptor pathway" "Formation of the cornified envelope" "2" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" "" "2623499657748455994" "False" "Low" "IsMasterProtein" "Q9NZ43" "Vesicle transport protein USE1 OS=Homo sapiens OX=9606 GN=USE1 PE=1 SV=2" "0.091" "False" "1.055" "4" "1" "1" "1" "259" "29.4" "9.07" "3.36" "1" "cell organization and biogenesis;protein metabolism;other metabolic processes;transport" "other membranes;ER/Golgi" "other molecular function" "Pf09753" "55850" "ENSG00000053501" "USE1" "hsa:55850; Q8NCK1; Q9BRT4; Q9NZ43" "" "COPI-dependent Golgi-to-ER retrograde traffic" "1" "0" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "High" "High" "High" "High" "High" "High" "High" "High" "High" "High" "1" ""